# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- FAD_binding_8 PF08022.12 KOG96028.1 - 1e-28 99.5 0.0 1e-28 99.5 0.0 1.9 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_6 PF08030.12 KOG96028.1 - 1.2e-23 84.0 0.0 2.1e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 KOG96028.1 - 1.7e-19 70.1 18.0 1.7e-19 70.1 18.0 2.2 2 1 1 3 3 3 1 Ferric reductase like transmembrane component FIT1_2 PF17357.2 KOG96029.1 - 2.3e-05 24.4 57.4 0.013 15.6 25.3 3.0 1 1 2 3 3 3 3 Facilitor Of iron transport 1 and 2 DUF3952 PF13130.6 KOG96029.1 - 0.011 15.9 0.6 3.6 7.8 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3952) PGM_PMM_III PF02880.16 KOG96029.1 - 0.053 13.7 8.1 0.094 12.9 2.0 2.4 1 1 1 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III FIT1_2 PF17357.2 KOG96030.1 - 4.7e-31 106.7 26.4 4.7e-31 106.7 26.4 1.6 2 0 0 2 2 2 1 Facilitor Of iron transport 1 and 2 Chorion_2 PF03964.15 KOG96030.1 - 0.012 16.5 4.1 0.017 15.9 4.1 1.3 1 0 0 1 1 1 0 Chorion family 2 SR-25 PF10500.9 KOG96030.1 - 0.59 9.7 10.8 0.77 9.3 10.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PAP1 PF08601.10 KOG96030.1 - 1.3 8.7 11.5 1.5 8.5 11.5 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 FAD-oxidase_C PF02913.19 KOG96031.1 - 1.4e-51 175.6 0.0 1.8e-51 175.2 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KOG96031.1 - 1.2e-35 122.2 0.0 2.3e-35 121.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain SNO PF01174.19 KOG96032.1 - 9.7e-87 289.7 0.1 1.1e-86 289.5 0.1 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 KOG96032.1 - 1.5e-09 37.8 0.0 4e-09 36.4 0.0 1.6 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 KOG96032.1 - 0.089 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family SOR_SNZ PF01680.17 KOG96033.1 - 4.5e-106 353.2 4.9 5.7e-106 352.9 4.9 1.1 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 KOG96033.1 - 2.8e-08 33.4 1.7 2.9e-07 30.1 0.0 2.3 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG Dus PF01207.17 KOG96033.1 - 0.004 16.3 0.3 2.6 7.1 0.1 2.5 2 1 1 3 3 3 2 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 KOG96033.1 - 0.018 14.5 0.1 0.077 12.4 0.0 2.0 2 0 0 2 2 2 0 Histidine biosynthesis protein NanE PF04131.14 KOG96033.1 - 0.05 12.8 1.3 0.17 11.1 0.1 2.2 2 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase NMO PF03060.15 KOG96033.1 - 0.056 12.8 1.3 0.57 9.5 0.1 2.3 2 0 0 2 2 2 0 Nitronate monooxygenase TetR_C_27 PF17935.1 KOG96033.1 - 0.08 13.0 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain 1-cysPrx_C PF10417.9 KOG96033.1 - 0.15 11.9 0.5 5 7.1 0.0 2.5 2 0 0 2 2 2 0 C-terminal domain of 1-Cys peroxiredoxin TMP-TENI PF02581.17 KOG96033.1 - 0.26 10.6 3.1 0.33 10.3 0.1 2.5 3 1 0 3 3 3 0 Thiamine monophosphate synthase NMT1 PF09084.11 KOG96034.1 - 5e-80 268.5 0.0 6.2e-80 268.2 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 KOG96034.1 - 0.00041 20.1 0.0 0.027 14.2 0.0 2.5 3 0 0 3 3 3 1 NMT1-like family 2Fe-2S_thioredx PF01257.19 KOG96034.1 - 0.0076 16.1 1.5 0.013 15.4 1.5 1.3 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Phosphonate-bd PF12974.7 KOG96034.1 - 0.0092 15.6 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein Flp_C PF05202.12 KOG96035.1 - 6.9e-149 494.0 3.2 6.9e-149 494.0 3.2 1.4 2 0 0 2 2 2 1 Recombinase Flp protein Flp_N PF03930.14 KOG96035.1 - 6.7e-28 96.5 0.7 1.3e-27 95.6 0.7 1.5 1 0 0 1 1 1 1 Recombinase Flp protein N-terminus Rep_4 PF05797.11 KOG96036.1 - 1e-111 373.4 0.0 1.2e-111 373.2 0.0 1.0 1 0 0 1 1 1 1 Yeast trans-acting factor (REP1/REP2) MitoNEET_N PF10660.9 KOG96038.1 - 0.14 12.2 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus ATP-synt_C PF00137.21 KOG96039.1 - 7.1e-13 48.7 10.2 8.7e-13 48.4 10.2 1.1 1 0 0 1 1 1 1 ATP synthase subunit C VAR1 PF05316.12 KOG96040.1 - 3.2e-136 453.8 149.7 4.1e-136 453.5 149.7 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein (VAR1) COX2 PF00116.20 KOG96041.1 - 4e-59 197.8 0.0 5.6e-59 197.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain COX2_TM PF02790.15 KOG96041.1 - 5.8e-33 112.9 1.9 9.5e-33 112.2 1.9 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, transmembrane domain Bac_export_1 PF01311.20 KOG96041.1 - 0.048 13.2 0.8 0.07 12.7 0.8 1.1 1 0 0 1 1 1 0 Bacterial export proteins, family 1 ASC PF00858.24 KOG96041.1 - 0.48 9.3 1.6 0.67 8.9 1.6 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel COX3 PF00510.18 KOG96042.1 - 3.3e-122 407.3 28.0 3.7e-122 407.1 28.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit III Cytochrome_B PF00033.19 KOG96043.1 - 6.5e-73 244.6 20.2 6.5e-73 244.6 20.2 2.3 3 0 0 3 3 3 1 Cytochrome b/b6/petB Cytochrom_B_N_2 PF13631.6 KOG96043.1 - 5.5e-38 130.6 15.3 5.5e-38 130.6 15.3 2.9 3 1 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.17 KOG96043.1 - 1e-34 118.9 4.4 1e-34 118.9 4.4 3.8 4 1 0 4 4 4 1 Cytochrome b(C-terminal)/b6/petD COX1 PF00115.20 KOG96045.1 - 2.7e-145 484.5 57.0 3.2e-145 484.3 57.0 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I Fun_ATP-synt_8 PF05933.13 KOG96046.1 - 1.2e-25 89.4 13.1 1.3e-25 89.3 13.1 1.0 1 0 0 1 1 1 1 Fungal ATP synthase protein 8 (A6L) YMF19 PF02326.15 KOG96046.1 - 0.91 10.4 8.8 0.91 10.3 8.8 1.0 1 0 0 1 1 1 0 Plant ATP synthase F0 ATP-synt_A PF00119.20 KOG96047.1 - 5.9e-45 153.8 35.3 7.3e-45 153.5 35.3 1.0 1 0 0 1 1 1 1 ATP synthase A chain Sugar_tr PF00083.24 KOG96048.1 - 1.7e-83 281.0 12.0 2e-83 280.8 12.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 KOG96048.1 - 8.2e-07 27.9 0.4 1.8e-06 26.8 0.4 1.5 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 KOG96048.1 - 6.3e-05 22.1 20.9 0.0022 17.0 14.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Zn_clus PF00172.18 KOG96049.1 - 1.7e-08 34.5 12.8 5.1e-08 32.9 12.8 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Malt_amylase_C PF16657.5 KOG96050.1 - 1.1e-06 28.7 0.0 3.5e-06 27.0 0.0 1.8 2 0 0 2 2 2 1 Maltogenic Amylase, C-terminal domain Mac PF12464.8 KOG96051.1 - 2e-13 50.3 0.0 2.9e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.24 KOG96051.1 - 6.1e-13 47.9 18.7 1.5e-09 37.2 8.4 3.5 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 KOG96051.1 - 1.9e-09 37.1 16.9 1.4e-08 34.3 7.3 3.2 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase MinC_C PF03775.16 KOG96051.1 - 2.7 8.0 8.2 7.5 6.6 0.1 2.3 1 1 1 2 2 2 0 Septum formation inhibitor MinC, C-terminal domain AA_permease PF00324.21 KOG96052.1 - 1.7e-105 353.4 40.9 1.9e-105 353.2 40.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG96052.1 - 6.9e-35 120.7 41.8 8.4e-35 120.4 41.8 1.0 1 0 0 1 1 1 1 Amino acid permease YwiC PF14256.6 KOG96052.1 - 3.2 8.1 16.3 0.14 12.5 0.5 4.2 5 0 0 5 5 5 0 YwiC-like protein S-methyl_trans PF02574.16 KOG96053.1 - 3.7e-57 194.2 0.0 4.2e-57 194.0 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase DUF2675 PF11247.8 KOG96053.1 - 0.085 13.0 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2675) ATP-synt_Eps PF04627.13 KOG96055.1 - 8.8e-18 64.0 3.5 1e-17 63.8 3.5 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain ABC_membrane PF00664.23 KOG96056.1 - 1.7e-60 205.0 8.7 2.4e-60 204.5 8.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KOG96056.1 - 2.3e-34 118.8 0.2 7.9e-34 117.1 0.0 2.1 2 0 0 2 2 2 1 ABC transporter AAA_5 PF07728.14 KOG96056.1 - 0.0009 19.3 0.1 0.034 14.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.29 KOG96056.1 - 0.0078 16.6 0.0 0.05 14.0 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOG96056.1 - 0.013 15.8 0.1 0.17 12.2 0.1 2.5 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOG96056.1 - 0.015 15.7 0.3 0.13 12.6 0.0 2.6 1 1 1 2 2 2 0 AAA ATPase domain IstB_IS21 PF01695.17 KOG96056.1 - 0.021 14.5 0.0 2.5 7.8 0.0 2.9 2 1 1 3 3 3 0 IstB-like ATP binding protein AAA_29 PF13555.6 KOG96056.1 - 0.025 14.3 0.0 0.089 12.6 0.0 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_ATPase PF09818.9 KOG96056.1 - 0.057 12.2 0.0 0.12 11.2 0.0 1.5 1 0 0 1 1 1 0 Predicted ATPase of the ABC class Ribosomal_60s PF00428.19 KOG96056.1 - 0.64 10.6 5.7 1.8 9.2 0.1 3.5 4 0 0 4 4 4 0 60s Acidic ribosomal protein PI-PLC-X PF00388.19 KOG96057.1 - 2.3e-51 173.2 0.2 1.1e-50 170.9 0.1 2.2 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KOG96057.1 - 2e-37 128.0 0.1 7.4e-37 126.2 0.1 2.0 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 KOG96057.1 - 1.2e-05 25.7 0.3 3e-05 24.4 0.3 1.7 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_7 PF13499.6 KOG96057.1 - 0.00012 22.4 1.9 0.0078 16.6 0.2 2.9 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.32 KOG96057.1 - 0.00095 18.6 1.0 0.0063 16.0 0.1 2.8 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KOG96057.1 - 0.0059 16.1 0.6 0.22 11.1 0.1 2.8 2 0 0 2 2 2 1 EF hand C2 PF00168.30 KOG96057.1 - 0.0098 16.2 0.0 0.026 14.8 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_6 PF13405.6 KOG96057.1 - 0.051 13.5 1.1 0.4 10.7 0.2 2.9 3 0 0 3 3 3 0 EF-hand domain DUF1192 PF06698.11 KOG96058.1 - 0.049 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) RrnaAD PF00398.20 KOG96059.1 - 6.6e-79 264.7 0.1 7.7e-79 264.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 KOG96059.1 - 2.7e-07 31.2 0.0 5.7e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOG96059.1 - 2.2e-05 25.0 0.0 4.7e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOG96059.1 - 0.00013 21.8 0.0 0.00021 21.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.16 KOG96059.1 - 0.0002 21.1 0.0 0.00035 20.4 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein CMAS PF02353.20 KOG96059.1 - 0.00042 19.7 0.0 0.0013 18.1 0.0 1.6 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 KOG96059.1 - 0.002 18.0 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.16 KOG96059.1 - 0.002 18.0 0.2 0.15 11.9 0.0 2.3 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase Methyltransf_12 PF08242.12 KOG96059.1 - 0.0024 18.6 0.0 0.0057 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOG96059.1 - 0.0088 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 KOG96059.1 - 0.024 13.9 0.3 0.093 12.1 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.7 KOG96059.1 - 0.046 13.7 0.0 0.48 10.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 KOG96059.1 - 0.048 13.5 0.0 0.08 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_28 PF02636.17 KOG96059.1 - 0.057 13.0 0.0 0.095 12.3 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase AAA_lid_4 PF17864.1 KOG96059.1 - 0.091 12.5 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 RuvB AAA lid domain Methyltransf_2 PF00891.18 KOG96059.1 - 0.14 11.4 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain AA_permease PF00324.21 KOG96060.1 - 1.2e-124 416.5 46.5 1.5e-124 416.2 46.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG96060.1 - 1.4e-33 116.4 45.6 1.8e-33 116.0 45.6 1.1 1 0 0 1 1 1 1 Amino acid permease Phage_holin_1 PF04531.13 KOG96060.1 - 7.3 7.2 7.0 24 5.6 1.8 2.9 2 0 0 2 2 2 0 Bacteriophage holin EamA PF00892.20 KOG96061.1 - 3.6e-26 92.0 28.4 5.2e-16 59.1 7.6 2.3 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 KOG96061.1 - 1.5e-05 24.5 3.9 1.5e-05 24.5 3.9 2.2 2 0 0 2 2 2 1 Triose-phosphate Transporter family Kelch_4 PF13418.6 KOG96062.1 - 3.4e-30 103.8 1.7 8.1e-07 29.0 0.4 6.7 5 2 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KOG96062.1 - 3.8e-28 97.2 2.4 1.8e-08 34.5 0.1 6.8 7 0 0 7 7 7 4 Galactose oxidase, central domain DUF4110 PF13422.6 KOG96062.1 - 7.4e-20 70.8 0.7 7.4e-20 70.8 0.7 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4110) Kelch_6 PF13964.6 KOG96062.1 - 3.4e-15 55.7 13.1 2.7e-06 27.4 0.2 6.6 5 2 1 6 6 6 3 Kelch motif Kelch_5 PF13854.6 KOG96062.1 - 2.3e-14 53.0 8.5 0.026 14.5 0.2 6.5 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KOG96062.1 - 3e-12 46.0 12.0 0.00018 21.3 0.1 5.8 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 KOG96062.1 - 1.3e-11 43.9 8.0 8.6e-05 22.0 0.1 6.3 6 1 0 6 6 6 3 Kelch motif BUD22 PF09073.10 KOG96062.1 - 0.019 14.4 35.5 0.013 14.9 18.1 2.2 2 0 0 2 2 2 0 BUD22 DUF2815 PF10991.8 KOG96062.1 - 1 9.3 14.4 0.17 11.8 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2815) Lyase_1 PF00206.20 KOG96063.1 - 2.4e-121 404.9 0.0 3.4e-121 404.4 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 KOG96063.1 - 9.8e-26 89.9 0.0 2.1e-25 88.9 0.0 1.6 1 0 0 1 1 1 1 Fumarase C C-terminus ADH_N PF08240.12 KOG96063.1 - 0.062 13.2 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain DUF2408 PF10303.9 KOG96064.1 - 6.5e-66 221.0 29.2 9.7e-47 158.9 6.2 5.1 2 2 3 5 5 5 4 Protein of unknown function (DUF2408) MtrG PF04210.13 KOG96064.1 - 0.32 10.9 1.3 51 3.8 0.0 3.4 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G 23S_rRNA_IVP PF05635.11 KOG96064.1 - 1 9.7 0.0 1 9.7 0.0 3.0 4 0 0 4 4 4 0 23S rRNA-intervening sequence protein MLD PF11647.8 KOG96064.1 - 1.3 9.4 7.4 0.3 11.4 0.5 3.6 4 2 0 4 4 4 0 Membrane Localization Domain DED PF01335.21 KOG96064.1 - 1.4 9.3 8.1 0.33 11.3 0.1 3.8 3 1 0 3 3 3 0 Death effector domain Adap_comp_sub PF00928.21 KOG96065.1 - 9.6e-93 310.4 0.8 1.4e-92 309.9 0.8 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KOG96065.1 - 1.6e-08 34.6 0.1 3.2e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Phos_pyr_kin PF08543.12 KOG96066.1 - 1.9e-78 263.2 0.1 2.4e-78 262.9 0.1 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 KOG96066.1 - 7.8e-70 234.9 0.0 1.1e-69 234.5 0.0 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 KOG96066.1 - 0.0026 17.1 0.0 0.0058 16.0 0.0 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase DUF2161 PF09929.9 KOG96066.1 - 0.2 11.8 0.0 0.4 10.8 0.0 1.4 1 0 0 1 1 1 0 Putative PD-(D/E)XK phosphodiesterase (DUF2161) Cyclin_N PF00134.23 KOG96067.1 - 1.3e-45 154.2 0.0 2.5e-45 153.3 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain BBP1_C PF15272.6 KOG96068.1 - 1.2e-56 191.6 26.9 2.3e-56 190.7 26.9 1.5 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal BBP1_N PF15271.6 KOG96068.1 - 3.7e-51 173.9 0.3 3.7e-51 173.9 0.3 2.8 2 1 0 2 2 2 1 Spindle pole body component BBP1, Mps2-binding protein Tup_N PF08581.10 KOG96068.1 - 0.63 10.4 19.3 3.9 7.8 4.6 2.9 1 1 1 2 2 2 0 Tup N-terminal Exonuc_VII_L PF02601.15 KOG96068.1 - 3.7 7.0 10.8 5.7 6.4 10.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mod_r PF07200.13 KOG96068.1 - 7.1 6.7 26.5 2.5 8.2 5.9 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein SAGA-Tad1 PF12767.7 KOG96069.1 - 9.7e-79 264.4 2.4 1.5e-78 263.8 0.7 1.9 2 0 0 2 2 2 1 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.14 KOG96069.1 - 4.6e-06 26.6 0.1 1e-05 25.4 0.1 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Microtub_bd PF16796.5 KOG96070.1 - 6.8e-23 81.3 2.1 6.8e-23 81.3 2.1 3.1 3 1 0 3 3 3 1 Microtubule binding DUF3450 PF11932.8 KOG96070.1 - 0.0026 17.1 14.2 0.0026 17.1 14.2 3.8 1 1 3 4 4 4 1 Protein of unknown function (DUF3450) AKNA PF12443.8 KOG96070.1 - 0.0047 17.5 1.9 0.0047 17.5 1.9 4.9 2 2 2 4 4 4 1 AT-hook-containing transcription factor BRE1 PF08647.11 KOG96070.1 - 0.0099 15.9 15.1 0.0099 15.9 15.1 4.6 4 1 1 5 5 5 1 BRE1 E3 ubiquitin ligase DUF1515 PF07439.11 KOG96070.1 - 1 9.4 6.2 0.22 11.6 0.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1515) DUF1843 PF08898.10 KOG96070.1 - 1.3 9.6 0.0 1.3 9.6 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) DUF4407 PF14362.6 KOG96070.1 - 4.4 6.6 27.1 14 4.9 18.5 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) PilJ PF13675.6 KOG96070.1 - 6.5 6.8 12.0 7 6.7 1.1 3.3 1 1 3 4 4 4 0 Type IV pili methyl-accepting chemotaxis transducer N-term Ndufs5 PF10200.9 KOG96070.1 - 8.7 6.7 6.7 5.6 7.3 0.5 3.1 3 0 0 3 3 3 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Fer2 PF00111.27 KOG96071.1 - 9.7e-13 47.9 1.4 1.3e-12 47.5 1.4 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Ribosomal_L36e PF01158.18 KOG96073.1 - 1.5e-30 105.2 1.8 1.7e-30 105.1 1.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e TetR_C_9 PF14514.6 KOG96073.1 - 0.1 12.7 0.1 0.11 12.6 0.1 1.1 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain RabGAP-TBC PF00566.18 KOG96074.1 - 1.4e-50 171.9 0.1 1.4e-50 171.9 0.1 2.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GIT_CC PF16559.5 KOG96074.1 - 0.25 11.2 14.5 0.096 12.6 3.5 2.7 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor PTPlike_phytase PF14566.6 KOG96074.1 - 2.2 8.4 8.8 22 5.2 8.8 2.8 1 1 0 1 1 1 0 Inositol hexakisphosphate DivIC PF04977.15 KOG96074.1 - 8.8 6.2 15.5 1.3 8.8 1.1 3.1 3 0 0 3 3 3 0 Septum formation initiator Cep57_CLD_2 PF14197.6 KOG96074.1 - 10 6.3 16.6 1.9 8.6 7.4 3.0 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Fungal_trans PF04082.18 KOG96075.1 - 3e-18 65.8 8.3 9.9e-18 64.1 8.3 1.9 1 0 0 1 1 1 1 Fungal specific transcription factor domain Gal4_dimer PF03902.13 KOG96075.1 - 5.7e-16 58.4 1.2 1.4e-15 57.2 1.2 1.6 1 0 0 1 1 1 1 Gal4-like dimerisation domain Zn_clus PF00172.18 KOG96075.1 - 1.8e-08 34.4 19.4 3e-08 33.7 19.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RtcR PF06956.11 KOG96075.1 - 0.088 12.2 0.1 0.19 11.1 0.1 1.5 1 0 0 1 1 1 0 Regulator of RNA terminal phosphate cyclase WD40 PF00400.32 KOG96076.1 - 1.4e-11 44.8 12.4 2.9e-05 24.7 0.1 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat Rhomboid PF01694.22 KOG96077.1 - 1.7e-23 83.3 11.0 2.8e-23 82.6 11.0 1.3 1 0 0 1 1 1 1 Rhomboid family DUF2075 PF09848.9 KOG96078.1 - 6.3e-113 377.7 0.0 7.5e-113 377.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 KOG96078.1 - 2.7e-07 30.9 0.0 8.8e-07 29.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 KOG96078.1 - 0.00032 21.1 0.0 0.00066 20.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOG96078.1 - 0.0015 19.0 0.0 0.0037 17.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain VirE PF05272.11 KOG96078.1 - 0.0031 17.3 0.0 0.006 16.3 0.0 1.4 1 0 0 1 1 1 1 Virulence-associated protein E AAA_30 PF13604.6 KOG96078.1 - 0.0034 17.1 0.0 0.028 14.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 KOG96078.1 - 0.0041 17.1 0.1 2.2 8.2 0.1 2.3 1 1 1 2 2 2 2 Type III restriction enzyme, res subunit RsgA_GTPase PF03193.16 KOG96078.1 - 0.0096 15.8 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_19 PF13245.6 KOG96078.1 - 0.022 15.1 0.0 0.085 13.2 0.0 1.9 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 KOG96078.1 - 0.031 13.3 0.0 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 KOG96078.1 - 0.04 13.8 0.0 0.081 12.8 0.0 1.7 1 1 0 1 1 1 0 NACHT domain AAA_11 PF13086.6 KOG96078.1 - 0.041 13.7 0.0 0.49 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 KOG96078.1 - 0.052 12.7 0.0 0.17 11.0 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_7 PF12775.7 KOG96078.1 - 0.062 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 KOG96078.1 - 0.066 13.6 0.0 0.58 10.6 0.0 2.6 2 1 0 2 2 2 0 RNA helicase DUF3466 PF11949.8 KOG96078.1 - 0.11 11.1 0.0 0.17 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3466) NB-ARC PF00931.22 KOG96078.1 - 0.14 11.3 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Sigma54_activat PF00158.26 KOG96078.1 - 0.17 11.6 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain UAA PF08449.11 KOG96079.1 - 1.9e-42 145.5 13.3 2.2e-42 145.3 13.3 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 KOG96079.1 - 6.7e-07 28.9 14.3 0.0019 17.6 2.1 2.5 2 1 1 3 3 3 3 Triose-phosphate Transporter family EamA PF00892.20 KOG96079.1 - 1.3e-06 28.7 9.1 1.3e-06 28.7 9.1 2.8 2 2 0 2 2 2 1 EamA-like transporter family Nuc_sug_transp PF04142.15 KOG96079.1 - 0.0074 15.5 6.1 0.34 10.0 0.5 2.3 1 1 1 2 2 2 2 Nucleotide-sugar transporter SRP68 PF16969.5 KOG96080.1 - 5.1e-61 207.4 8.8 7.8e-61 206.7 8.8 1.3 1 1 0 1 1 1 1 RNA-binding signal recognition particle 68 TPR_12 PF13424.6 KOG96080.1 - 0.081 13.2 0.5 0.36 11.2 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Peptidase_S10 PF00450.22 KOG96080.1 - 0.5 9.7 3.0 0.19 11.1 0.3 1.6 2 0 0 2 2 2 0 Serine carboxypeptidase RasGAP_C PF03836.15 KOG96081.1 - 2.7e-28 98.8 1.5 2.7e-28 98.8 1.5 2.6 2 0 0 2 2 2 1 RasGAP C-terminus RasGAP PF00616.19 KOG96081.1 - 8.2e-24 84.5 0.5 2.3e-23 83.0 0.5 1.8 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase CH PF00307.31 KOG96081.1 - 4.6e-12 46.1 0.0 2.1e-11 44.0 0.0 2.3 1 0 0 1 1 1 1 Calponin homology (CH) domain IQ PF00612.27 KOG96081.1 - 1.3e-08 33.8 20.8 0.073 12.9 0.7 8.9 9 0 0 9 9 9 3 IQ calmodulin-binding motif XkdW PF09636.10 KOG96081.1 - 0.017 15.2 0.2 0.9 9.7 0.0 2.8 2 0 0 2 2 2 0 XkdW protein YabA PF06156.13 KOG96081.1 - 0.081 13.6 0.2 0.6 10.8 0.1 2.6 2 0 0 2 2 2 0 Initiation control protein YabA Cortex-I_coil PF09304.10 KOG96081.1 - 6.4 7.0 6.8 13 6.1 0.2 3.9 4 1 1 5 5 5 0 Cortexillin I, coiled coil TBCC PF07986.12 KOG96082.1 - 0.0021 17.8 2.7 0.015 15.0 2.7 2.2 1 1 0 1 1 1 1 Tubulin binding cofactor C HSP90 PF00183.18 KOG96083.1 - 3.2e-219 729.1 34.6 4.3e-219 728.7 34.6 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 KOG96083.1 - 1.4e-13 51.3 0.0 2.7e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KOG96083.1 - 4.4e-09 36.3 0.0 1.3e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ubiq-assoc PF09145.10 KOG96083.1 - 0.07 13.1 0.2 2.6 8.1 0.0 3.0 3 0 0 3 3 3 0 Ubiquitin-associated Peptidase_S10 PF00450.22 KOG96083.1 - 0.11 11.9 0.3 0.73 9.2 0.0 2.1 2 0 0 2 2 2 0 Serine carboxypeptidase Tau95 PF09734.9 KOG96083.1 - 5.2 7.9 7.5 1.5 9.6 3.0 2.4 3 0 0 3 3 3 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Ank_2 PF12796.7 KOG96084.1 - 3.2e-27 94.9 1.8 7.3e-14 52.1 0.1 2.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOG96084.1 - 1.3e-16 60.7 0.1 1.4e-11 44.6 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOG96084.1 - 8.1e-14 51.5 0.3 1.4e-08 34.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOG96084.1 - 6.8e-11 41.4 0.0 0.00011 22.3 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 KOG96084.1 - 1.9e-10 40.7 0.0 1.3e-05 25.4 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat eIF-5_eIF-2B PF01873.17 KOG96085.1 - 3.2e-38 130.2 0.1 5.7e-38 129.4 0.1 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 IF2_N PF04760.15 KOG96085.1 - 0.00047 19.9 0.7 0.015 15.1 0.0 3.1 3 0 0 3 3 3 1 Translation initiation factor IF-2, N-terminal region TF_Zn_Ribbon PF08271.12 KOG96085.1 - 0.026 14.1 0.3 0.049 13.2 0.3 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding RR_TM4-6 PF06459.12 KOG96085.1 - 0.054 13.3 3.8 0.073 12.9 3.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF35_N PF12172.8 KOG96085.1 - 0.099 12.5 0.2 1.4 8.9 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Pkinase PF00069.25 KOG96086.1 - 1.8e-34 119.3 0.0 1.9e-24 86.5 0.0 2.3 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96086.1 - 1.2e-16 60.8 0.0 2.3e-16 59.8 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase TIP49 PF06068.13 KOG96087.1 - 4.4e-158 526.1 1.6 6e-158 525.6 1.6 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 KOG96087.1 - 6.9e-27 93.4 1.1 2.4e-26 91.6 0.9 2.1 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 KOG96087.1 - 1.1e-08 35.6 0.7 2.2e-05 24.9 0.1 2.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOG96087.1 - 3.4e-07 30.1 0.3 0.0018 18.0 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain DnaB_C PF03796.15 KOG96087.1 - 2.4e-05 23.8 2.1 3.6e-05 23.2 0.2 2.0 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 KOG96087.1 - 3.8e-05 24.2 0.2 0.00016 22.1 0.2 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOG96087.1 - 0.0023 18.2 0.1 0.29 11.4 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 KOG96087.1 - 0.0031 17.9 1.9 0.0095 16.3 0.5 2.4 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KOG96087.1 - 0.015 15.3 0.2 3.9 7.5 0.0 2.9 2 2 0 2 2 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KOG96087.1 - 0.02 14.3 0.7 0.45 9.9 0.2 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 KOG96087.1 - 0.024 14.2 0.9 0.06 12.9 0.1 1.9 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 KOG96087.1 - 0.046 13.4 0.0 8.9 6.0 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_28 PF13521.6 KOG96087.1 - 0.056 13.7 0.1 0.19 12.0 0.1 1.9 1 0 0 1 1 1 0 AAA domain CBFD_NFYB_HMF PF00808.23 KOG96087.1 - 0.074 13.3 0.2 0.26 11.6 0.2 2.0 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone AAA_7 PF12775.7 KOG96087.1 - 0.22 11.0 0.8 0.79 9.2 0.0 2.2 3 0 0 3 3 3 0 P-loop containing dynein motor region ATP-synt_C PF00137.21 KOG96088.1 - 1.1e-32 112.2 31.5 1e-18 67.4 7.5 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Mis14 PF08641.12 KOG96089.1 - 2.2e-36 125.1 6.0 2.2e-36 125.1 6.0 2.0 2 0 0 2 2 2 1 Kinetochore protein Mis14 like Syntaxin PF00804.25 KOG96090.1 - 9.2e-22 77.7 16.6 4.8e-21 75.3 16.6 2.0 1 1 0 1 1 1 1 Syntaxin SNARE PF05739.19 KOG96090.1 - 1.4e-14 53.8 4.6 1.4e-14 53.8 4.6 2.2 2 0 0 2 2 2 1 SNARE domain Synaptobrevin PF00957.21 KOG96090.1 - 0.00019 21.1 2.3 0.00019 21.1 2.3 2.4 2 0 0 2 2 2 1 Synaptobrevin SLATT_5 PF18160.1 KOG96090.1 - 0.0064 15.8 0.0 0.0064 15.8 0.0 1.8 2 1 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain family 5 DUF2277 PF10041.9 KOG96090.1 - 0.009 16.3 0.8 2.2 8.7 1.1 2.7 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2277) DUF2207 PF09972.9 KOG96090.1 - 0.012 14.4 1.3 0.015 14.1 0.2 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Baculo_PEP_C PF04513.12 KOG96090.1 - 0.028 14.4 2.4 0.59 10.2 0.0 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5383 PF17355.2 KOG96090.1 - 0.076 13.4 0.2 0.076 13.4 0.2 2.4 2 1 1 3 3 3 0 Family of unknown function (DUF5383) BLOC1_2 PF10046.9 KOG96090.1 - 0.29 11.5 8.4 6.9 7.0 2.1 3.1 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 T2SSF PF00482.23 KOG96090.1 - 0.33 10.9 2.1 1.4 8.9 2.1 2.1 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F Collectrin PF16959.5 KOG96090.1 - 2.1 8.1 7.7 3.1 7.5 6.9 1.7 1 1 0 1 1 1 0 Renal amino acid transporter Fic PF02661.18 KOG96090.1 - 2.1 9.3 4.2 18 6.3 0.2 2.9 1 1 2 3 3 3 0 Fic/DOC family PBP1_TM PF14812.6 KOG96090.1 - 2.3 8.7 5.7 0.41 11.0 0.4 2.3 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2116 PF09889.9 KOG96090.1 - 2.7 8.0 6.1 0.56 10.2 1.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DASH_Dam1 PF08653.10 KOG96090.1 - 3 7.7 4.5 9.5 6.1 0.3 2.6 2 0 0 2 2 2 0 DASH complex subunit Dam1 SlyX PF04102.12 KOG96090.1 - 4.1 8.1 8.2 1.2 9.7 2.2 2.7 2 1 0 2 2 2 0 SlyX Allexi_40kDa PF05549.11 KOG96090.1 - 5.7 6.4 10.4 0.9 9.0 1.8 2.1 1 1 0 2 2 2 0 Allexivirus 40kDa protein DUF745 PF05335.13 KOG96090.1 - 8 6.1 17.1 0.29 10.8 8.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Fas_alpha_ACP PF18325.1 KOG96091.1 - 5.3e-72 241.4 0.0 1.7e-71 239.8 0.0 1.9 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 KOG96091.1 - 2.9e-69 232.8 0.1 6.7e-69 231.6 0.1 1.7 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 KOG96091.1 - 7.4e-20 71.6 0.0 1.9e-19 70.3 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 KOG96091.1 - 2.9e-16 59.6 0.0 7.8e-16 58.2 0.0 1.8 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 KOG96091.1 - 4.1e-13 49.4 0.1 1.8e-12 47.3 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 KOG96091.1 - 0.00081 19.3 0.0 0.0023 17.9 0.0 1.7 1 0 0 1 1 1 1 KR domain SPG4 PF17325.2 KOG96091.1 - 0.23 12.6 1.6 0.41 11.7 0.2 2.1 2 0 0 2 2 2 0 Stationary phase protein 4 zf-H2C2_2 PF13465.6 KOG96092.1 - 2.1e-10 40.5 2.3 2.1e-10 40.5 2.3 2.5 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 KOG96092.1 - 6.7e-09 35.7 6.9 0.00012 22.4 0.9 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG96092.1 - 0.0001 22.9 6.7 0.026 15.3 0.8 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger SR-25 PF10500.9 KOG96092.1 - 0.0037 16.9 12.2 0.0037 16.9 12.2 1.9 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein zf-C2H2_3rep PF18868.1 KOG96092.1 - 0.045 14.4 2.4 0.13 12.9 2.1 1.9 1 1 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zf-MYST PF17772.1 KOG96092.1 - 0.14 11.8 0.1 0.4 10.3 0.1 1.8 1 1 0 1 1 1 0 MYST family zinc finger domain zf-C2H2_jaz PF12171.8 KOG96092.1 - 0.31 11.4 4.3 0.2 12.0 0.8 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOG96092.1 - 0.36 11.3 3.6 0.95 9.9 0.1 2.9 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 KOG96092.1 - 3.2 7.6 5.0 4 7.3 1.0 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Herpes_pp85 PF04637.12 KOG96092.1 - 3.3 6.0 7.4 5.2 5.4 7.4 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) mRNA_triPase PF02940.15 KOG96094.1 - 2.6e-67 226.8 0.4 2.6e-67 226.8 0.4 1.7 2 0 0 2 2 2 1 mRNA capping enzyme, beta chain Glycos_transf_2 PF00535.26 KOG96095.1 - 1.5e-26 93.2 0.0 1.9e-26 92.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 KOG96095.1 - 4e-07 29.8 0.0 5.1e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 KOG96095.1 - 0.00087 19.2 0.0 0.0014 18.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 KOG96095.1 - 0.014 15.9 0.0 0.027 15.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 ABC_tran PF00005.27 KOG96096.1 - 6.2e-48 162.8 0.0 1e-24 87.6 0.0 3.9 2 2 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOG96096.1 - 3.6e-12 46.2 0.0 0.0013 18.2 0.0 3.8 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KOG96096.1 - 2.1e-11 44.2 9.2 0.013 15.3 0.0 5.0 3 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system Chromo PF00385.24 KOG96096.1 - 9e-11 41.5 1.5 2.3e-10 40.2 1.5 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_29 PF13555.6 KOG96096.1 - 9.7e-07 28.4 0.1 0.074 12.8 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KOG96096.1 - 2.1e-06 27.8 0.0 0.051 13.7 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG96096.1 - 3.7e-06 26.9 0.0 0.055 13.4 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 KOG96096.1 - 1e-05 26.1 14.4 0.015 15.8 0.1 4.3 3 1 1 4 4 4 2 AAA domain AAA_22 PF13401.6 KOG96096.1 - 3.8e-05 24.0 0.0 0.58 10.4 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 KOG96096.1 - 0.00022 21.0 5.4 0.66 9.6 0.0 4.0 3 1 0 3 3 3 2 AAA ATPase domain AAA_18 PF13238.6 KOG96096.1 - 0.00054 20.5 0.1 1.5 9.4 0.0 3.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KOG96096.1 - 0.0011 19.3 0.2 4.2 7.8 0.0 3.3 4 0 0 4 4 2 2 RNA helicase MeaB PF03308.16 KOG96096.1 - 0.0012 17.9 0.6 0.9 8.5 0.0 2.7 3 0 0 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 KOG96096.1 - 0.0028 18.0 0.0 0.65 10.4 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 KOG96096.1 - 0.0029 17.3 0.3 6.8 6.4 0.4 3.5 3 1 0 3 3 2 0 AAA domain AAA_28 PF13521.6 KOG96096.1 - 0.0037 17.5 0.0 3 8.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOG96096.1 - 0.0041 17.3 0.0 5.1 7.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KOG96096.1 - 0.0065 16.9 0.0 5.9 7.3 0.0 3.0 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_27 PF13514.6 KOG96096.1 - 0.01 15.5 0.0 1.1 8.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 KOG96096.1 - 0.013 15.6 3.8 0.72 9.9 0.1 3.8 4 0 0 4 4 4 0 Helicase HerA, central domain NACHT PF05729.12 KOG96096.1 - 0.016 15.1 0.1 2.7 7.9 0.0 3.1 2 0 0 2 2 2 0 NACHT domain DUF815 PF05673.13 KOG96096.1 - 0.055 12.6 0.1 9 5.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MukB PF04310.12 KOG96096.1 - 0.058 13.2 0.1 7.7 6.3 0.0 2.7 3 0 0 3 3 2 0 MukB N-terminal Roc PF08477.13 KOG96096.1 - 0.059 13.6 0.0 21 5.4 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 KOG96096.1 - 0.061 13.1 0.2 5.7 6.6 0.0 3.1 3 0 0 3 3 3 0 AAA domain CLP1_P PF16575.5 KOG96096.1 - 0.072 12.9 0.1 7.4 6.3 0.0 2.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Dynamin_N PF00350.23 KOG96096.1 - 0.072 13.1 0.0 5.3 7.1 0.0 3.1 2 1 0 2 2 2 0 Dynamin family Thymidylate_kin PF02223.17 KOG96096.1 - 0.1 12.3 0.3 1.2 8.8 0.0 2.6 3 0 0 3 3 2 0 Thymidylate kinase HEAT PF02985.22 KOG96096.1 - 0.12 12.7 0.6 6.2 7.4 0.0 3.7 4 0 0 4 4 3 0 HEAT repeat ABC_tran_Xtn PF12848.7 KOG96096.1 - 3.1 7.9 7.4 0.17 11.9 0.6 2.5 2 0 0 2 2 2 0 ABC transporter Polysacc_synt_4 PF04669.13 KOG96097.1 - 4.5e-19 68.7 1.9 2.3e-17 63.2 1.9 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis CBAH PF02275.18 KOG96097.1 - 0.02 14.5 0.3 0.028 14.1 0.3 1.1 1 0 0 1 1 1 0 Linear amide C-N hydrolases, choloylglycine hydrolase family NitrOD1 PF18549.1 KOG96097.1 - 0.039 13.9 0.1 0.12 12.3 0.1 1.8 1 0 0 1 1 1 0 Nitrosopumilus output domain 1 Cation_efflux PF01545.21 KOG96098.1 - 1e-46 159.2 9.4 1.3e-46 158.8 9.4 1.1 1 0 0 1 1 1 1 Cation efflux family GluRS_N PF18466.1 KOG96098.1 - 0.097 13.1 0.1 0.25 11.8 0.1 1.6 1 0 0 1 1 1 0 Glutamate--tRNA ligase N-terminal domain UPF0061 PF02696.14 KOG96100.1 - 2.3e-164 547.6 0.3 2.8e-164 547.4 0.3 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Apolipoprotein PF01442.18 KOG96100.1 - 0.022 14.7 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain TRP PF06011.12 KOG96102.1 - 5.2e-156 519.7 37.0 7.9e-156 519.0 37.0 1.3 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 KOG96102.1 - 1.9e-40 138.4 1.0 3.1e-40 137.7 1.0 1.4 1 0 0 1 1 1 1 ML-like domain E1_DerP2_DerF2 PF02221.15 KOG96102.1 - 0.013 15.9 0.1 0.023 15.1 0.1 1.4 1 0 0 1 1 1 0 ML domain CytochromB561_N PF09786.9 KOG96102.1 - 0.4 9.6 8.7 0.43 9.5 2.9 2.3 2 0 0 2 2 2 0 Cytochrome B561, N terminal Ribosomal_L1 PF00687.21 KOG96103.1 - 5.2e-40 137.4 0.6 6.1e-40 137.1 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Cyclin PF08613.11 KOG96104.1 - 1.5e-15 57.9 2.5 1.5e-15 57.9 2.5 2.4 2 1 0 2 2 2 1 Cyclin Hydin_ADK PF17213.3 KOG96104.1 - 0.053 13.8 1.3 1 9.6 0.2 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain SUIM_assoc PF16619.5 KOG96104.1 - 0.078 13.1 13.0 0.24 11.5 13.0 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 RP-C_C PF11800.8 KOG96104.1 - 0.1 12.7 1.8 0.29 11.2 0.1 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region RIBIOP_C PF04950.12 KOG96105.1 - 3.1e-86 289.4 1.1 3.1e-86 289.4 1.1 2.5 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 KOG96105.1 - 1.4e-29 102.0 0.0 6.6e-29 99.8 0.0 2.3 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 KOG96105.1 - 8.4e-06 25.5 3.2 0.0018 17.9 0.0 3.5 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 KOG96105.1 - 1.9e-05 24.8 0.1 0.00014 22.1 0.0 2.5 2 1 0 2 2 1 1 AAA domain AAA PF00004.29 KOG96105.1 - 2.7e-05 24.6 0.0 7.7e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOG96105.1 - 4.5e-05 23.9 0.0 0.00012 22.6 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOG96105.1 - 0.00035 20.9 0.1 0.0013 19.0 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 KOG96105.1 - 0.0011 18.7 0.1 0.013 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 KOG96105.1 - 0.0026 17.7 0.1 0.0091 15.9 0.1 1.8 1 1 0 1 1 1 1 NACHT domain MMR_HSR1 PF01926.23 KOG96105.1 - 0.0029 17.7 0.1 0.012 15.7 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 KOG96105.1 - 0.0054 17.0 0.0 0.019 15.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KOG96105.1 - 0.0057 16.0 0.0 0.2 10.9 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.6 KOG96105.1 - 0.0065 17.0 0.0 0.0065 17.0 0.0 3.8 4 0 0 4 4 3 1 AAA domain NB-ARC PF00931.22 KOG96105.1 - 0.0071 15.6 0.5 0.018 14.3 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain AAA_19 PF13245.6 KOG96105.1 - 0.0078 16.6 0.1 0.019 15.3 0.1 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KOG96105.1 - 0.0094 16.3 0.0 0.031 14.7 0.0 1.9 1 0 0 1 1 1 1 RNA helicase ABC_tran PF00005.27 KOG96105.1 - 0.015 15.8 0.0 0.015 15.8 0.0 2.5 3 0 0 3 3 1 0 ABC transporter AAA_11 PF13086.6 KOG96105.1 - 0.016 15.0 0.1 0.016 15.0 0.1 4.3 4 1 0 4 4 4 0 AAA domain cobW PF02492.19 KOG96105.1 - 0.021 14.4 0.1 0.046 13.3 0.1 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 KOG96105.1 - 0.024 14.6 0.0 0.057 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 KOG96105.1 - 0.026 14.4 0.3 0.058 13.3 0.3 1.6 1 0 0 1 1 1 0 NTPase AAA_7 PF12775.7 KOG96105.1 - 0.028 13.9 1.1 0.054 13.0 0.1 2.0 2 0 0 2 2 1 0 P-loop containing dynein motor region MobB PF03205.14 KOG96105.1 - 0.042 13.8 0.4 0.12 12.3 0.0 2.1 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.6 KOG96105.1 - 0.043 13.4 0.0 0.099 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 KOG96105.1 - 0.059 13.1 0.0 12 5.6 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation WAC_Acf1_DNA_bd PF10537.9 KOG96106.1 - 6.9e-27 93.9 0.3 3.6e-26 91.6 0.3 2.4 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 KOG96106.1 - 6.5e-11 42.6 1.6 1.9e-10 41.1 0.0 2.8 3 0 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 KOG96106.1 - 1.6e-07 31.5 1.0 1.9e-05 24.8 0.0 3.2 3 0 0 3 3 3 1 DDT domain DUF5097 PF17020.5 KOG96106.1 - 0.015 15.6 0.1 0.076 13.4 0.1 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5097) WHIM1 PF15612.6 KOG96106.1 - 0.018 14.6 0.0 0.044 13.3 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 Ubiq_cyt_C_chap PF03981.12 KOG96107.1 - 1.7e-41 141.6 0.1 2.4e-41 141.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone HK PF02110.15 KOG96108.1 - 3.1e-97 324.8 1.0 5.4e-97 324.0 0.8 1.5 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 KOG96108.1 - 1.1e-57 194.3 0.0 1.6e-57 193.8 0.0 1.2 1 0 0 1 1 1 1 Thiamine monophosphate synthase LRR_9 PF14580.6 KOG96109.1 - 1.5e-13 50.6 2.0 2.5e-13 49.9 2.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KOG96109.1 - 0.026 14.9 17.3 0.08 13.4 2.3 4.4 2 1 1 4 4 4 0 Leucine Rich repeats (2 copies) FNIP PF05725.12 KOG96109.1 - 0.44 10.7 1.8 50 4.2 0.0 3.0 2 1 0 2 2 2 0 FNIP Repeat LRR_8 PF13855.6 KOG96109.1 - 0.79 9.5 14.4 0.52 10.1 8.3 3.2 1 1 3 4 4 4 0 Leucine rich repeat PseudoU_synth_1 PF01416.20 KOG96110.1 - 8e-12 45.6 0.0 1.1e-10 42.0 0.0 2.5 2 0 0 2 2 2 1 tRNA pseudouridine synthase DUF2344 PF10105.9 KOG96110.1 - 0.083 12.7 2.3 0.18 11.7 0.0 2.6 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2344) UPF0113_N PF17833.1 KOG96111.1 - 2.9e-28 98.2 0.1 4.4e-28 97.7 0.1 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 KOG96111.1 - 1.2e-24 86.3 0.0 2.4e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 UPF0113 PUA domain SRP72 PF08492.12 KOG96112.1 - 4.2e-12 46.3 6.6 4.2e-12 46.3 6.6 2.5 2 0 0 2 2 1 1 SRP72 RNA-binding domain SRP_TPR_like PF17004.5 KOG96112.1 - 9.7e-09 35.3 13.3 3e-07 30.5 4.6 4.3 4 2 1 5 5 5 2 Putative TPR-like repeat TPR_2 PF07719.17 KOG96112.1 - 2.5e-07 30.3 5.3 0.02 15.0 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOG96112.1 - 3.2e-07 30.5 1.0 0.0012 19.1 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOG96112.1 - 0.00019 21.9 0.1 1.1 10.3 0.0 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOG96112.1 - 0.00035 20.6 9.4 0.0055 16.8 0.1 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOG96112.1 - 0.00077 19.9 1.5 0.14 12.7 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOG96112.1 - 0.0069 16.2 0.4 0.52 10.2 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOG96112.1 - 0.0087 16.3 4.8 6.3 7.1 0.1 4.1 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 Clathrin PF00637.20 KOG96112.1 - 0.033 14.0 13.7 0.66 9.8 0.2 4.7 4 2 2 6 6 6 0 Region in Clathrin and VPS TPR_1 PF00515.28 KOG96112.1 - 0.037 13.9 7.8 0.84 9.6 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOG96112.1 - 0.056 13.5 3.4 0.45 10.7 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 KOG96112.1 - 0.063 12.6 0.1 0.82 9.0 0.0 2.3 2 0 0 2 2 2 0 MalT-like TPR region TPR_6 PF13174.6 KOG96112.1 - 0.35 11.6 4.1 1e+02 3.9 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOG96112.1 - 0.69 9.7 2.8 1.2 8.9 0.1 2.7 2 0 0 2 2 2 0 TPR repeat Pkinase PF00069.25 KOG96113.1 - 1.7e-72 244.0 0.1 2.2e-72 243.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96113.1 - 1.4e-46 158.9 0.0 1.9e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG96113.1 - 0.00018 20.9 0.0 0.0025 17.2 0.0 2.4 2 1 0 2 2 2 1 Kinase-like FTA2 PF13095.6 KOG96113.1 - 0.014 15.0 1.2 0.37 10.4 0.1 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KOG96113.1 - 0.058 12.7 0.1 0.12 11.7 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L21e PF01157.18 KOG96113.1 - 0.063 13.1 0.2 0.15 11.9 0.2 1.6 1 0 0 1 1 1 0 Ribosomal protein L21e Pkinase_fungal PF17667.1 KOG96113.1 - 0.16 10.7 0.1 0.28 9.9 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase SET PF00856.28 KOG96114.1 - 6e-08 33.3 0.0 1.6e-07 31.9 0.0 1.7 1 0 0 1 1 1 1 SET domain Radical_SAM PF04055.21 KOG96115.1 - 3.6e-22 79.5 0.0 8.1e-22 78.4 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.12 KOG96115.1 - 4.4e-22 78.2 0.0 1.1e-21 77.0 0.0 1.7 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.25 KOG96115.1 - 6.4e-17 62.1 0.0 1.3e-16 61.1 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin GDPD PF03009.17 KOG96116.1 - 4.2e-43 147.9 0.0 4.9e-43 147.7 0.0 1.0 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 KOG96116.1 - 0.051 14.0 0.3 0.28 11.7 0.1 2.4 2 1 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family Pkinase PF00069.25 KOG96117.1 - 1.1e-23 84.0 0.0 2e-23 83.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96117.1 - 1.1e-13 51.0 0.0 2.1e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOG96117.1 - 3.1e-08 32.8 0.0 3.1e-08 32.8 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KOG96117.1 - 0.055 13.4 1.9 0.083 12.8 0.0 2.1 3 0 0 3 3 3 0 Phosphotransferase enzyme family Pkinase PF00069.25 KOG96118.1 - 6.8e-73 245.3 0.0 1e-72 244.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96118.1 - 4e-40 137.7 0.0 5.6e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG96118.1 - 1.1e-05 25.0 0.4 4e-05 23.1 0.0 2.1 1 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KOG96118.1 - 0.044 12.7 1.6 0.095 11.6 1.6 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 KOG96118.1 - 0.1 11.6 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 AFT PF08731.11 KOG96119.1 - 1.7e-34 118.5 6.9 1.3e-19 70.6 0.2 2.7 2 1 1 3 3 3 2 Transcription factor AFT ARL2_Bind_BART PF11527.8 KOG96119.1 - 0.048 13.8 0.1 0.13 12.4 0.1 1.8 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART DBD_Tnp_Mut PF03108.15 KOG96119.1 - 0.19 11.7 0.2 20 5.2 0.0 2.4 2 0 0 2 2 2 0 MuDR family transposase USP8_dimer PF08969.11 KOG96119.1 - 0.31 11.2 4.1 0.099 12.8 0.9 1.8 2 0 0 2 2 2 0 USP8 dimerisation domain DUF1771 PF08590.10 KOG96122.1 - 3.4e-18 65.8 8.1 5.4e-18 65.1 8.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 KOG96122.1 - 4.4e-12 46.2 0.6 7.4e-12 45.5 0.1 1.6 2 0 0 2 2 2 1 Smr domain DUF1031 PF06275.11 KOG96122.1 - 0.16 12.2 1.5 0.76 10.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1031) Ribosomal_L30_N PF08079.12 KOG96123.1 - 1e-21 76.9 17.3 1.6e-21 76.3 17.3 1.3 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 KOG96123.1 - 5.3e-19 67.8 4.2 9.8e-19 67.0 2.9 2.1 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Tropomyosin PF00261.20 KOG96123.1 - 0.0046 16.3 4.8 0.0067 15.8 4.8 1.1 1 0 0 1 1 1 1 Tropomyosin CSRNP_N PF16019.5 KOG96123.1 - 0.013 15.4 0.5 0.019 14.9 0.5 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF724 PF05266.14 KOG96123.1 - 1.5 8.7 5.7 2.2 8.1 5.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TLD PF07534.16 KOG96124.1 - 6.1e-28 97.8 0.0 1.8e-27 96.3 0.0 1.8 1 1 0 1 1 1 1 TLD Rad9 PF04139.13 KOG96125.1 - 8.6e-11 41.8 0.6 0.00018 21.0 0.1 2.3 2 0 0 2 2 2 2 Rad9 NUFIP1 PF10453.9 KOG96126.1 - 1.8e-18 66.1 4.3 3.3e-18 65.3 0.1 3.0 3 0 0 3 3 3 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) MINDY_DUB PF04424.13 KOG96128.1 - 3.7e-31 107.6 0.1 7.9e-31 106.5 0.1 1.6 1 0 0 1 1 1 1 MINDY deubiquitinase RRM_1 PF00076.22 KOG96129.1 - 3.8e-10 39.4 0.4 9.8e-10 38.1 0.1 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOG96129.1 - 0.0033 17.0 0.0 0.013 15.1 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COA2 PF17051.5 KOG96130.1 - 1.2e-27 95.8 0.1 1.2e-27 95.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 MBOAT PF03062.19 KOG96131.1 - 6.5e-78 262.5 26.2 6.5e-78 262.5 26.2 1.7 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Swi3 PF07962.12 KOG96131.1 - 0.17 11.9 0.2 5 7.2 0.0 2.4 1 1 1 2 2 2 0 Replication Fork Protection Component Swi3 NAD_kinase PF01513.21 KOG96132.1 - 5.1e-51 173.6 0.0 6.8e-51 173.2 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 KOG96132.1 - 0.06 13.0 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain MF_alpha_N PF05436.11 KOG96133.1 - 2.7e-33 113.7 1.1 3.6e-33 113.3 1.1 1.2 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus MF_alpha PF04648.12 KOG96133.1 - 1.1e-25 88.9 45.4 2.8e-06 27.4 4.0 4.2 4 0 0 4 4 4 4 Yeast mating factor alpha hormone Apidaecin PF00807.17 KOG96133.1 - 0.0061 16.6 12.6 5.7 7.1 0.2 4.3 4 0 0 4 4 4 3 Apidaecin TOBE_3 PF12857.7 KOG96133.1 - 0.062 13.2 0.1 82 3.2 0.0 3.8 1 1 3 4 4 4 0 TOBE-like domain EMA PF02488.15 KOG96133.1 - 0.2 11.3 1.3 3.7 7.1 0.0 2.8 1 1 2 3 3 3 0 Merozoite Antigen AMPK1_CBM PF16561.5 KOG96134.1 - 0.00091 19.4 0.9 0.0029 17.8 0.9 1.9 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase DUF5484 PF17583.2 KOG96134.1 - 0.013 15.1 0.6 0.013 15.1 0.6 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5484) RRM_1 PF00076.22 KOG96135.1 - 7.8e-23 80.1 1.0 9.3e-07 28.6 0.0 4.8 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOG96135.1 - 4.8e-10 39.2 0.1 0.045 13.6 0.0 4.4 4 0 0 4 4 4 4 Occluded RNA-recognition motif RRM_5 PF13893.6 KOG96135.1 - 0.00091 18.8 0.2 0.093 12.3 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KOG96135.1 - 0.0053 16.8 0.1 2.2 8.4 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.6 KOG96135.1 - 0.0085 16.1 0.1 1.9 8.6 0.0 3.0 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif DUF3855 PF12967.7 KOG96135.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3855) Ribosomal_L36 PF00444.18 KOG96136.1 - 2.2e-20 72.5 8.7 3e-20 72.1 8.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L36 Crust_neurohorm PF01147.17 KOG96136.1 - 0.081 12.8 1.5 0.12 12.2 1.5 1.2 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family WD40 PF00400.32 KOG96137.1 - 4.4e-13 49.5 18.5 2.2e-06 28.3 0.2 8.4 9 0 0 9 9 9 2 WD domain, G-beta repeat Baculo_p47 PF05112.12 KOG96137.1 - 0.0011 18.6 1.4 0.0011 18.6 1.4 2.4 3 0 0 3 3 3 1 Baculovirus P47 protein YmzC PF14157.6 KOG96137.1 - 0.058 13.5 1.3 0.83 9.8 0.1 3.1 3 0 0 3 3 3 0 YmzC-like protein PHD PF00628.29 KOG96138.1 - 4.4e-12 45.7 8.6 8e-12 44.9 8.6 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 KOG96138.1 - 0.073 12.6 5.2 0.12 12.0 5.2 1.4 1 0 0 1 1 1 0 PHD-finger TCO89 PF10452.9 KOG96139.1 - 5.3e-122 408.8 57.4 1.7e-121 407.1 57.4 1.8 1 1 0 1 1 1 1 TORC1 subunit TCO89 Metallophos PF00149.28 KOG96140.1 - 3.7e-38 132.1 0.1 5.9e-38 131.4 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KOG96140.1 - 2.2e-17 63.2 0.1 4.6e-17 62.2 0.1 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain RRM_1 PF00076.22 KOG96141.1 - 1e-12 47.7 0.0 1.6e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Homeobox_KN PF05920.11 KOG96142.1 - 5.9e-19 67.7 1.5 1.2e-18 66.7 1.5 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KOG96142.1 - 1.4e-05 24.9 0.7 3.7e-05 23.5 0.7 1.7 1 0 0 1 1 1 1 Homeodomain RasGEF_N PF00618.20 KOG96142.1 - 0.073 13.3 0.4 0.073 13.3 0.4 2.0 2 1 1 3 3 3 0 RasGEF N-terminal motif TFR_dimer PF04253.15 KOG96143.1 - 5.4e-25 87.8 0.0 1.2e-24 86.7 0.0 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.22 KOG96143.1 - 0.076 13.0 0.0 0.22 11.5 0.0 1.8 1 1 0 1 1 1 0 PA domain PIGA PF08288.12 KOG96144.1 - 3e-44 149.5 1.8 6.9e-44 148.3 1.8 1.7 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 KOG96144.1 - 1.7e-30 106.2 0.3 2.8e-30 105.5 0.3 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 KOG96144.1 - 1.4e-25 89.8 0.0 2.5e-25 89.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOG96144.1 - 7.6e-22 78.2 0.1 1.7e-21 77.1 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 KOG96144.1 - 3e-11 44.0 0.0 4.6e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 KOG96144.1 - 0.00017 21.6 0.3 0.0006 19.9 0.3 1.8 2 0 0 2 2 2 1 Glycosyl transferase 4-like Glyco_transf_5 PF08323.11 KOG96144.1 - 0.081 12.6 0.0 0.58 9.8 0.0 2.2 1 1 0 1 1 1 0 Starch synthase catalytic domain Glyco_trans_1_2 PF13524.6 KOG96144.1 - 0.15 12.5 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 CAP_GLY PF01302.25 KOG96145.1 - 1.7e-15 56.8 0.2 3e-15 56.0 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain PRKG1_interact PF15898.5 KOG96145.1 - 0.025 15.5 6.2 0.025 15.5 6.2 6.0 2 2 3 5 5 5 0 cGMP-dependent protein kinase interacting domain bZIP_1 PF00170.21 KOG96145.1 - 0.18 11.9 0.2 0.18 11.9 0.2 8.4 6 2 2 8 8 8 0 bZIP transcription factor ATG16 PF08614.11 KOG96145.1 - 0.35 11.1 53.3 0.11 12.7 8.8 3.9 3 1 0 3 3 3 0 Autophagy protein 16 (ATG16) UbiA PF01040.18 KOG96146.1 - 3.3e-48 164.2 9.4 5.1e-48 163.6 9.4 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Oxidored_FMN PF00724.20 KOG96147.1 - 6.4e-133 443.2 0.0 7.4e-133 443.0 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Cyt-b5 PF00173.28 KOG96148.1 - 6.2e-15 55.1 0.0 7.9e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain RRM_9 PF18444.1 KOG96149.1 - 2.7e-32 110.4 0.4 5.5e-32 109.4 0.4 1.6 1 0 0 1 1 1 1 RNA recognition motif TAP_C PF03943.13 KOG96149.1 - 4.7e-14 51.7 0.2 1.7e-13 50.0 0.2 2.1 1 0 0 1 1 1 1 TAP C-terminal domain LRR_9 PF14580.6 KOG96149.1 - 6e-07 29.1 1.4 1.1e-06 28.3 1.4 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KOG96149.1 - 3.4e-06 27.3 12.3 0.00015 22.1 2.2 3.5 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) NTF2 PF02136.20 KOG96149.1 - 0.035 14.7 2.2 0.28 11.7 1.3 2.8 2 1 0 2 2 2 0 Nuclear transport factor 2 (NTF2) domain EKAL PF17986.1 KOG96150.1 - 0.045 13.8 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 EMP3-KAHRP-like N-terminal domain DNA_pol_B PF00136.21 KOG96151.1 - 2.5e-114 382.5 0.3 8.3e-114 380.8 0.4 1.9 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 KOG96151.1 - 3.6e-19 69.1 4.2 4e-11 42.6 1.0 2.6 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 KOG96151.1 - 1e-11 45.1 11.6 3.2e-11 43.5 11.6 2.0 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DZR PF12773.7 KOG96151.1 - 4.1 7.5 5.8 11 6.1 5.8 1.8 1 0 0 1 1 1 0 Double zinc ribbon Atg29_N PF18388.1 KOG96152.1 - 8.8e-17 60.7 0.3 1.5e-16 59.9 0.3 1.4 1 0 0 1 1 1 1 Atg29 N-terminal domain SET PF00856.28 KOG96153.1 - 3e-13 50.5 0.9 1.4e-12 48.4 0.9 1.9 1 1 0 1 1 1 1 SET domain HATPase_c_3 PF13589.6 KOG96154.1 - 1.1e-11 44.8 0.0 2.3e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KOG96154.1 - 2.4e-07 31.2 0.1 1.1e-06 29.2 0.0 2.1 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 KOG96154.1 - 7e-05 22.6 0.1 0.0013 18.5 0.0 2.6 2 1 0 3 3 3 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 KOG96154.1 - 0.0015 18.2 0.1 0.0069 16.1 0.1 2.2 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain STIMATE PF12400.8 KOG96156.1 - 1.9e-44 151.2 7.6 4e-44 150.2 7.6 1.5 1 0 0 1 1 1 1 STIMATE family TMEM192 PF14802.6 KOG96156.1 - 0.046 12.8 0.0 0.11 11.6 0.0 1.6 1 1 0 1 1 1 0 TMEM192 family TyeA PF09059.10 KOG96157.1 - 0.053 13.6 0.8 4.4 7.5 0.1 3.0 3 1 0 3 3 3 0 TyeA HEPN_Apea PF18739.1 KOG96157.1 - 2.2 8.7 8.3 7.4 7.1 0.2 3.9 4 0 0 4 4 4 0 Apea-like HEPN tRNA-synt_1 PF00133.22 KOG96158.1 - 9.2e-42 143.1 0.1 4.1e-33 114.5 0.1 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 KOG96158.1 - 1.2e-16 60.5 0.7 4.5e-09 35.5 0.0 4.1 4 0 0 4 4 4 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 KOG96158.1 - 3.2e-13 49.9 0.0 9.6e-13 48.4 0.0 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 KOG96158.1 - 1.6e-06 27.7 0.0 3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Pet20 PF08692.10 KOG96159.1 - 1.2e-14 55.2 10.3 1.5e-08 35.4 0.0 3.6 3 1 1 4 4 4 2 Mitochondrial protein Pet20 Methyltransf_15 PF09445.10 KOG96161.1 - 1.5e-66 223.0 0.0 2.2e-66 222.5 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.18 KOG96161.1 - 1.2e-06 28.4 0.1 3.5e-05 23.6 0.1 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 KOG96161.1 - 1.4e-06 28.2 0.0 2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOG96161.1 - 1.9e-06 28.5 0.0 4.4e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 KOG96161.1 - 0.001 18.7 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 N6_N4_Mtase PF01555.18 KOG96161.1 - 0.0022 17.7 0.6 0.16 11.6 0.1 2.2 1 1 1 2 2 2 2 DNA methylase MethyltransfD12 PF02086.15 KOG96161.1 - 0.0093 15.7 1.2 0.012 15.3 0.0 1.8 3 0 0 3 3 3 1 D12 class N6 adenine-specific DNA methyltransferase CMAS PF02353.20 KOG96161.1 - 0.012 14.9 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 KOG96161.1 - 0.02 15.5 0.0 0.053 14.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KOG96161.1 - 0.023 14.2 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 KOG96161.1 - 0.04 13.8 0.0 0.07 13.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Kinesin PF00225.23 KOG96163.1 - 6.3e-107 357.4 0.3 8.9e-107 356.9 0.3 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOG96163.1 - 1.6e-22 80.1 0.0 6e-22 78.2 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding Lzipper-MIP1 PF14389.6 KOG96163.1 - 0.36 11.2 1.8 60 4.0 1.4 3.4 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Med9 PF07544.13 KOG96163.1 - 1.1 9.4 4.0 15 5.8 0.1 3.1 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 RAP1 PF07218.11 KOG96163.1 - 9.9 4.3 11.7 16 3.6 11.7 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Asp PF00026.23 KOG96164.1 - 1.2e-103 346.8 0.0 1.5e-103 346.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOG96164.1 - 5.3e-16 59.4 0.7 5.8e-14 52.7 0.7 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 KOG96164.1 - 0.0021 18.7 0.0 0.44 11.2 0.0 2.8 2 1 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 KOG96164.1 - 0.0055 17.3 0.0 0.47 11.0 0.0 2.4 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 KOG96164.1 - 0.19 11.5 0.0 0.66 9.7 0.0 1.9 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal Pkinase PF00069.25 KOG96165.1 - 2.5e-79 266.3 0.0 5.5e-79 265.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96165.1 - 1e-37 129.8 0.0 2.1e-37 128.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 KOG96165.1 - 4.5e-28 97.4 1.4 1.1e-15 57.7 0.1 2.8 2 0 0 2 2 2 2 FHA domain Yop-YscD_cpl PF16697.5 KOG96165.1 - 1.7e-10 41.1 0.0 5.6e-07 29.8 0.0 2.9 2 0 0 2 2 2 2 Inner membrane component of T3SS, cytoplasmic domain Kinase-like PF14531.6 KOG96165.1 - 4e-06 26.3 0.0 7.8e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOG96165.1 - 2.3e-05 24.4 0.0 0.0098 15.8 0.0 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KOG96165.1 - 3.2e-05 23.4 0.0 6.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FHA_2 PF17913.1 KOG96165.1 - 0.00073 19.7 2.6 3.8 7.8 0.0 4.2 4 0 0 4 4 4 1 FHA domain RIO1 PF01163.22 KOG96165.1 - 0.0038 16.9 0.0 0.0075 15.9 0.0 1.4 1 0 0 1 1 1 1 RIO1 family TMEM51 PF15345.6 KOG96165.1 - 0.058 13.2 7.2 6.2 6.6 5.0 2.5 2 0 0 2 2 2 0 Transmembrane protein 51 DUF5426 PF17473.2 KOG96165.1 - 0.088 13.1 0.1 0.3 11.3 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5426) PTPA PF03095.15 KOG96166.1 - 3.9e-114 381.2 1.8 4.5e-114 381.0 1.8 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein P2 PF07194.11 KOG96166.1 - 0.15 12.1 0.2 0.28 11.3 0.2 1.4 1 0 0 1 1 1 0 P2 response regulator binding domain WD40 PF00400.32 KOG96167.1 - 2.6e-31 107.2 14.3 1.5e-05 25.6 0.2 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG96167.1 - 3.5e-05 24.0 0.4 0.24 11.7 0.0 4.5 1 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOG96167.1 - 0.0032 16.2 8.4 0.14 10.8 0.0 4.0 2 1 3 5 5 5 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 KOG96167.1 - 0.015 14.1 0.1 1.4 7.6 0.1 3.6 1 1 2 3 3 3 0 Nup133 N terminal like RNF111_N PF15303.6 KOG96167.1 - 0.018 14.8 1.5 0.032 14.0 1.5 1.3 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase Arkadia N-terminus Pkinase PF00069.25 KOG96168.1 - 2.1e-67 227.3 0.2 7.7e-67 225.4 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96168.1 - 3.1e-38 131.5 0.0 4.7e-38 130.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG96168.1 - 7.4e-09 35.3 0.0 1.2e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KOG96168.1 - 0.00046 19.2 0.0 0.00046 19.2 0.0 2.5 2 1 0 2 2 2 1 Haspin like kinase domain bZIP_C PF12498.8 KOG96168.1 - 0.03 15.3 2.4 0.13 13.2 2.4 2.2 1 0 0 1 1 1 0 Basic leucine-zipper C terminal Kdo PF06293.14 KOG96168.1 - 0.035 13.4 0.3 0.42 9.9 0.1 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APG5 PF04106.12 KOG96169.1 - 2e-34 119.2 0.0 2.7e-34 118.7 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Apg5 ACAS_N PF16177.5 KOG96169.1 - 0.074 13.0 2.1 23 5.0 0.2 3.2 3 0 0 3 3 3 0 Acetyl-coenzyme A synthetase N-terminus Neuralized PF07177.12 KOG96169.1 - 0.12 12.3 0.0 0.34 10.9 0.0 1.9 1 1 0 1 1 1 0 Neuralized ACPS PF01648.20 KOG96170.1 - 9.1e-23 80.6 0.0 1.2e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 KOG96170.1 - 0.14 12.3 0.0 0.37 11.0 0.0 1.7 2 0 0 2 2 2 0 4'-phosphopantetheinyl transferase N-terminal domain ABC_membrane_2 PF06472.15 KOG96171.1 - 1.1e-88 297.1 3.1 1.1e-88 297.1 3.1 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 KOG96171.1 - 2.7e-15 57.1 0.0 1e-14 55.2 0.0 2.0 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KOG96171.1 - 0.00058 19.4 0.2 0.56 9.6 0.1 2.6 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOG96171.1 - 0.049 14.0 0.1 0.14 12.5 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain Nop53 PF07767.11 KOG96172.1 - 6.8e-96 322.1 45.1 8e-96 321.8 45.1 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DivIC PF04977.15 KOG96172.1 - 0.47 10.3 5.9 0.74 9.6 3.9 2.4 2 0 0 2 2 2 0 Septum formation initiator DUF4611 PF15387.6 KOG96172.1 - 1.2 9.4 15.4 0.16 12.2 8.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) PspB PF06667.12 KOG96172.1 - 6.8 6.8 10.4 0.24 11.5 2.4 2.6 3 0 0 3 3 3 0 Phage shock protein B Oxysterol_BP PF01237.18 KOG96173.1 - 8.5e-61 205.8 3.7 3.1e-54 184.3 0.1 2.1 1 1 1 2 2 2 2 Oxysterol-binding protein POC3_POC4 PF10448.9 KOG96174.1 - 3.9e-27 95.0 0.0 4.5e-27 94.8 0.0 1.0 1 0 0 1 1 1 1 20S proteasome chaperone assembly proteins 3 and 4 PAC4 PF16093.5 KOG96174.1 - 0.0037 17.4 0.0 0.0077 16.4 0.0 1.7 1 1 0 1 1 1 1 Proteasome assembly chaperone 4 DUF2020 PF09449.10 KOG96174.1 - 0.042 13.7 0.0 0.16 11.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2020) Ribosomal_L35Ae PF01247.18 KOG96175.1 - 4e-42 142.3 0.7 4.5e-42 142.1 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 KOG96175.1 - 0.0055 16.9 0.0 3.8 7.8 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Pkinase PF00069.25 KOG96176.1 - 1.4e-59 201.6 0.0 2.5e-59 200.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96176.1 - 2.8e-38 131.7 0.0 4.9e-38 130.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG96176.1 - 4.8e-08 32.6 0.0 8.7e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOG96176.1 - 0.0088 16.0 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 KOG96176.1 - 0.011 15.4 0.1 0.028 14.0 0.1 1.6 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 KOG96176.1 - 0.076 12.4 0.2 0.2 11.0 0.2 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 KOG96177.1 - 1.4e-72 244.2 0.0 1.9e-72 243.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96177.1 - 2.2e-37 128.7 0.0 5e-37 127.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG96177.1 - 6e-07 29.1 0.0 1.2e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOG96177.1 - 0.0011 18.3 0.0 0.002 17.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KOG96177.1 - 0.0019 17.8 0.1 0.5 10.0 0.0 2.2 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 KOG96177.1 - 0.002 16.9 0.0 0.0038 16.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOG96177.1 - 0.012 15.5 0.0 0.13 12.1 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOG96177.1 - 0.044 12.7 0.0 0.085 11.8 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 KOG96177.1 - 0.082 12.0 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 WD40 PF00400.32 KOG96178.1 - 0.00036 21.3 6.8 0.045 14.6 0.0 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat PHD PF00628.29 KOG96179.1 - 5e-11 42.3 4.8 5e-11 42.3 4.8 2.1 2 0 0 2 2 2 1 PHD-finger DUF4140 PF13600.6 KOG96179.1 - 1 9.9 2.9 34 5.0 0.2 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) NifU_N PF01592.16 KOG96181.1 - 1.3e-57 193.5 0.0 1.6e-57 193.2 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain TSCPD PF12637.7 KOG96181.1 - 0.03 14.6 0.1 0.053 13.8 0.1 1.4 1 0 0 1 1 1 0 TSCPD domain Mito_carr PF00153.27 KOG96182.1 - 5e-61 202.7 2.2 7.7e-26 89.9 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 KOG96182.1 - 0.22 11.9 2.3 0.23 11.9 0.1 2.1 2 2 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family Zn_clus PF00172.18 KOG96183.1 - 0.002 18.2 11.9 0.006 16.7 11.9 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CtaG_Cox11 PF04442.14 KOG96184.1 - 1.5e-61 206.8 0.0 2.2e-61 206.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Ribosomal_L5e PF17144.4 KOG96185.1 - 9.6e-84 279.3 0.0 1.5e-83 278.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 KOG96185.1 - 3.1e-31 108.2 0.9 3.1e-31 108.2 0.9 1.8 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Ribosomal_L18p PF00861.22 KOG96185.1 - 0.0044 17.4 0.3 0.014 15.7 0.0 1.8 2 0 0 2 2 2 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Thr_synth_N PF14821.6 KOG96185.1 - 0.022 15.0 0.1 1.4 9.2 0.0 2.7 2 0 0 2 2 2 0 Threonine synthase N terminus NAC PF01849.18 KOG96185.1 - 0.047 13.7 0.0 0.088 12.8 0.0 1.3 1 0 0 1 1 1 0 NAC domain Phage_holin_3_3 PF16083.5 KOG96185.1 - 0.12 12.5 0.0 1.8 8.7 0.0 2.3 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III YEATS PF03366.16 KOG96187.1 - 3.6e-20 71.7 0.0 5.9e-20 71.0 0.0 1.4 1 0 0 1 1 1 1 YEATS family BET PF17035.5 KOG96187.1 - 1e-06 28.8 0.0 2.1e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation TRF PF08558.10 KOG96188.1 - 1.2e-82 277.1 0.5 1.7e-82 276.6 0.5 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 KOG96188.1 - 4.1e-09 36.5 2.3 1.8e-08 34.4 1.9 2.3 2 1 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOG96188.1 - 0.0027 17.9 0.1 0.0089 16.3 0.1 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Linker_histone PF00538.19 KOG96189.1 - 4.5e-47 158.3 11.8 3.4e-25 88.2 0.1 3.2 3 0 0 3 3 3 2 linker histone H1 and H5 family WD40 PF00400.32 KOG96190.1 - 3.9e-07 30.7 5.7 0.004 18.0 0.2 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat DCAF15_WD40 PF14939.6 KOG96190.1 - 0.03 14.0 0.3 0.32 10.6 0.0 2.6 3 0 0 3 3 3 0 DDB1-and CUL4-substrate receptor 15, WD repeat IBN_N PF03810.19 KOG96191.1 - 3.3e-17 62.2 0.3 3.3e-17 62.2 0.3 3.4 4 0 0 4 4 4 1 Importin-beta N-terminal domain SLATT_5 PF18160.1 KOG96191.1 - 0.0024 17.2 0.1 0.0057 16.0 0.1 1.6 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain family 5 Stn1_C PF12659.7 KOG96191.1 - 0.024 14.6 0.7 0.15 12.0 0.7 2.4 1 0 0 1 1 1 0 Telomere capping C-terminal wHTH Xpo1 PF08389.12 KOG96191.1 - 0.028 14.5 11.7 0.035 14.2 0.6 5.1 4 1 1 5 5 5 0 Exportin 1-like protein CRISPR_Cse2 PF09485.10 KOG96191.1 - 0.37 11.3 1.3 0.78 10.3 0.0 2.2 2 0 0 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) Spc29 PF17082.5 KOG96192.1 - 2.4e-69 233.9 13.1 2.7e-69 233.7 13.1 1.0 1 0 0 1 1 1 1 Spindle Pole Component 29 CEP209_CC5 PF16574.5 KOG96192.1 - 0.023 14.9 0.6 0.37 11.0 0.0 2.2 2 0 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 Fib_alpha PF08702.10 KOG96192.1 - 0.035 14.3 2.7 0.15 12.2 0.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Ribonuclease_T2 PF00445.18 KOG96193.1 - 2e-44 152.0 2.6 2.9e-44 151.5 2.6 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family Tfb2 PF03849.14 KOG96194.1 - 1.6e-139 464.8 1.9 2.5e-139 464.2 1.9 1.3 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 KOG96194.1 - 1.2e-22 80.1 1.0 3.5e-22 78.6 0.4 2.2 3 0 0 3 3 3 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 KOG96194.1 - 6.9e-05 23.0 0.0 0.00018 21.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Mei5 PF10376.9 KOG96195.1 - 2e-38 132.4 23.0 2.3e-38 132.1 23.0 1.0 1 0 0 1 1 1 1 Double-strand recombination repair protein MafB19-deam PF14437.6 KOG96195.1 - 0.00026 20.7 2.9 0.00026 20.7 0.7 1.9 1 1 0 2 2 2 1 MafB19-like deaminase VPS38 PF17649.1 KOG96195.1 - 8 5.2 21.5 0.06 12.2 9.6 2.0 1 1 1 2 2 2 0 Vacuolar protein sorting 38 APG6 PF04111.12 KOG96196.1 - 9.7e-60 201.6 2.4 2.3e-59 200.3 2.4 1.7 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 KOG96196.1 - 2.7e-24 86.2 23.6 2.7e-24 86.2 23.6 2.2 2 0 0 2 2 2 1 Apg6 coiled-coil region Atg14 PF10186.9 KOG96196.1 - 0.032 13.3 17.9 1.2 8.2 0.0 2.7 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 KOG96196.1 - 6.9 5.9 10.2 13 5.0 10.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DEAD PF00270.29 KOG96197.1 - 6e-49 166.2 0.0 3.7e-48 163.6 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG96197.1 - 2.8e-32 111.4 0.0 6.3e-32 110.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG96197.1 - 5.3e-05 23.3 0.0 0.00028 21.0 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOG96197.1 - 0.004 16.4 0.0 0.0058 15.9 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 KOG96197.1 - 0.062 12.6 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Mit_ribos_Mrp51 PF11709.8 KOG96198.1 - 3.6e-66 224.2 2.4 9.9e-64 216.2 2.4 2.2 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit Csm1_B PF18211.1 KOG96198.1 - 0.15 11.9 0.1 0.34 10.8 0.1 1.6 1 0 0 1 1 1 0 Csm1 subunit domain B NUDIX PF00293.28 KOG96199.1 - 5.3e-31 107.4 0.1 9.7e-31 106.5 0.0 1.5 2 0 0 2 2 2 1 NUDIX domain Hist_deacetyl PF00850.19 KOG96200.1 - 2.8e-51 174.8 0.2 5.4e-51 173.9 0.2 1.5 1 0 0 1 1 1 1 Histone deacetylase domain RhoGAP PF00620.27 KOG96201.1 - 2.3e-38 131.4 2.9 9.8e-38 129.4 0.1 2.9 3 0 0 3 3 3 1 RhoGAP domain PX PF00787.24 KOG96201.1 - 2.4e-08 33.9 0.1 9.3e-08 32.0 0.1 2.1 1 0 0 1 1 1 1 PX domain PH PF00169.29 KOG96201.1 - 2.7e-08 34.2 0.0 1.1e-07 32.3 0.0 2.2 1 0 0 1 1 1 1 PH domain DUF1708 PF08101.11 KOG96201.1 - 0.0046 16.2 0.0 0.0046 16.2 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF1708) Csm1_N PF18504.1 KOG96201.1 - 0.17 12.3 1.8 0.7 10.3 1.8 2.1 1 0 0 1 1 1 0 Csm1 N-terminal domain 2-Hacid_dh_C PF02826.19 KOG96202.1 - 7.1e-35 120.0 0.0 1.2e-34 119.3 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOG96202.1 - 0.0016 18.1 0.0 0.0027 17.4 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ApbA PF02558.16 KOG96202.1 - 0.071 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Phage_Treg PF04761.12 KOG96202.1 - 0.16 12.1 2.6 2.2 8.4 0.2 2.9 3 0 0 3 3 3 0 Lactococcus bacteriophage putative transcription regulator PEX11 PF05648.14 KOG96203.1 - 4.3e-09 36.2 4.2 1.6e-06 27.8 2.7 2.3 2 0 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Arginase PF00491.21 KOG96204.1 - 2.9e-75 253.4 0.0 3.5e-75 253.1 0.0 1.0 1 0 0 1 1 1 1 Arginase family GDPD PF03009.17 KOG96205.1 - 1.2e-92 310.4 0.1 2.9e-92 309.1 0.1 1.7 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 KOG96205.1 - 1.4e-23 83.3 0.8 6.4e-10 39.5 0.0 4.1 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOG96205.1 - 3.9e-16 59.2 3.0 3.4e-06 27.5 0.3 6.1 3 3 3 6 6 6 5 Ankyrin repeats (many copies) SPX PF03105.19 KOG96205.1 - 1.4e-15 58.1 30.8 1.3e-11 45.1 0.9 4.0 3 1 2 5 5 5 3 SPX domain Ank_3 PF13606.6 KOG96205.1 - 3.1e-13 48.6 7.7 0.072 13.7 0.1 7.3 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 KOG96205.1 - 1.4e-10 41.1 2.8 0.12 12.8 0.0 6.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 KOG96205.1 - 3.1e-09 36.9 1.4 0.21 12.0 0.0 5.0 3 1 0 4 4 4 3 Ankyrin repeats (many copies) DUF3567 PF12091.8 KOG96206.1 - 0.048 13.8 0.1 0.086 13.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3567) Oxidored-like PF09791.9 KOG96207.1 - 2.4e-25 87.9 3.3 4.5e-25 87.0 3.3 1.5 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal HSP70 PF00012.20 KOG96208.1 - 7.6e-199 661.8 2.7 7.6e-199 661.8 2.7 1.8 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 KOG96208.1 - 1.4e-10 40.5 0.2 7.7e-10 38.1 0.0 1.9 2 0 0 2 2 2 1 MreB/Mbl protein Trans_reg_C PF00486.28 KOG96208.1 - 0.066 13.3 0.0 0.32 11.1 0.0 2.2 1 0 0 1 1 1 0 Transcriptional regulatory protein, C terminal NLE PF08154.12 KOG96208.1 - 0.11 13.0 0.1 0.57 10.7 0.0 2.3 2 0 0 2 2 2 0 NLE (NUC135) domain Peptidase_M22 PF00814.25 KOG96208.1 - 0.16 11.6 0.6 17 5.0 0.2 3.1 1 1 2 3 3 3 0 Glycoprotease family MAGE PF01454.19 KOG96208.1 - 0.53 10.0 4.9 0.18 11.5 1.5 1.9 1 1 1 2 2 2 0 MAGE family GYF PF02213.16 KOG96209.1 - 3.3e-17 61.9 0.1 7.7e-17 60.7 0.1 1.7 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 KOG96209.1 - 0.00051 19.8 0.1 0.0047 16.7 0.0 2.3 2 0 0 2 2 2 1 GYF domain 2 tRNA-synt_2 PF00152.20 KOG96210.1 - 7.3e-101 337.4 0.1 9.5e-101 337.0 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOG96210.1 - 7.2e-06 25.9 0.1 1.5e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KOG96210.1 - 0.017 14.6 0.1 0.55 9.7 0.0 2.8 3 0 0 3 3 3 0 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.25 KOG96210.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) Lactamase_B_2 PF12706.7 KOG96211.1 - 6.4e-31 107.4 0.0 1.1e-30 106.7 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 KOG96211.1 - 3.8e-11 43.2 0.0 7.1e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KOG96211.1 - 0.092 12.7 0.1 0.19 11.7 0.0 1.5 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily PAXNEB PF05625.11 KOG96212.1 - 3e-90 303.0 0.7 4.2e-90 302.6 0.7 1.1 1 0 0 1 1 1 1 PAXNEB protein WD40 PF00400.32 KOG96213.1 - 4.9e-05 24.0 0.1 0.0096 16.8 0.0 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG96213.1 - 0.03 14.6 0.0 2.4 8.5 0.0 3.6 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain TraG-D_C PF12696.7 KOG96213.1 - 0.039 13.9 1.1 0.097 12.7 0.1 2.1 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG CCDC24 PF15669.5 KOG96214.1 - 0.014 15.2 5.6 0.016 15.1 0.4 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family PRTP PF01366.18 KOG96214.1 - 0.024 12.7 1.6 0.029 12.4 1.6 1.0 1 0 0 1 1 1 0 Herpesvirus processing and transport protein DUF2681 PF10883.8 KOG96214.1 - 0.024 15.0 0.4 0.058 13.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) MCU PF04678.13 KOG96214.1 - 0.031 14.4 0.4 0.031 14.4 0.4 2.1 1 1 1 2 2 2 0 Mitochondrial calcium uniporter Lzipper-MIP1 PF14389.6 KOG96214.1 - 0.061 13.6 4.0 0.9 9.9 2.4 2.4 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 CHIP_TPR_N PF18391.1 KOG96214.1 - 1.8 9.4 8.1 0.16 12.7 2.6 2.0 3 0 0 3 3 3 0 CHIP N-terminal tetratricopeptide repeat domain Romo1 PF10247.9 KOG96215.1 - 1e-27 96.2 10.0 1.5e-27 95.8 10.0 1.2 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 tRNA-synt_1b PF00579.25 KOG96216.1 - 1.3e-83 280.8 0.0 1.8e-83 280.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 KOG96216.1 - 0.0028 17.4 0.1 0.0051 16.6 0.1 1.4 1 0 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain Peptidase_M73 PF12389.8 KOG96216.1 - 0.035 13.9 0.3 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 Camelysin metallo-endopeptidase Vma12 PF11712.8 KOG96217.1 - 0.032 14.3 1.6 0.038 14.1 1.6 1.1 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase PIG-Y PF15159.6 KOG96217.1 - 0.72 10.8 8.5 1.1 10.2 8.5 1.3 1 1 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Rad4 PF03835.15 KOG96218.1 - 6.5e-11 42.1 2.1 9.7e-11 41.6 1.4 1.7 1 1 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 KOG96218.1 - 5e-09 36.6 0.2 1.1e-08 35.5 0.1 1.7 2 0 0 2 2 2 1 Transglutaminase-like superfamily TSC21 PF15217.6 KOG96218.1 - 0.1 12.6 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 TSC21 family Zn_Tnp_IS1595 PF12760.7 KOG96218.1 - 0.51 10.4 6.4 1.9 8.5 6.4 2.0 1 1 0 1 1 1 0 Transposase zinc-ribbon domain IBR PF01485.21 KOG96218.1 - 2.9 8.2 8.8 0.4 10.9 2.7 2.6 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Abhydrolase_1 PF00561.20 KOG96219.1 - 2.5e-23 83.0 0.0 7.6e-23 81.5 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOG96219.1 - 1.9e-10 40.4 0.0 1e-09 38.0 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOG96219.1 - 1.5e-06 29.0 0.0 3.3e-06 27.9 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family ORC3_N PF07034.11 KOG96219.1 - 0.0037 16.4 0.0 0.0056 15.8 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus Peptidase_S9 PF00326.21 KOG96219.1 - 0.022 14.2 0.0 1.4 8.4 0.0 2.4 2 0 0 2 2 2 0 Prolyl oligopeptidase family Sec62 PF03839.16 KOG96220.1 - 3.8e-73 245.6 1.4 4.9e-73 245.2 1.4 1.1 1 0 0 1 1 1 1 Translocation protein Sec62 NOG1_N PF17835.1 KOG96221.1 - 2.4e-49 167.4 2.5 1.1e-48 165.2 0.1 2.5 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOGCT PF08155.11 KOG96221.1 - 2.4e-26 91.5 2.2 2.4e-26 91.5 2.2 2.1 2 0 0 2 2 2 1 NOGCT (NUC087) domain NOG1 PF06858.14 KOG96221.1 - 6.3e-26 89.9 0.2 1.9e-25 88.4 0.2 1.9 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 KOG96221.1 - 7.5e-16 58.2 0.0 1.8e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOG96221.1 - 2.1e-07 30.6 0.0 4.7e-07 29.5 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 KOG96221.1 - 0.0024 17.3 0.1 0.0051 16.2 0.1 1.6 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KOG96221.1 - 0.0052 16.7 0.1 4.2 7.3 0.1 3.3 3 0 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 KOG96221.1 - 0.013 15.9 0.0 0.36 11.2 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain Dynamin_N PF00350.23 KOG96221.1 - 0.019 15.0 0.2 4.4 7.3 0.0 3.2 2 1 1 3 3 3 0 Dynamin family Roc PF08477.13 KOG96221.1 - 0.059 13.6 0.0 0.32 11.2 0.0 2.3 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 KOG96221.1 - 1.2 9.7 0.0 1.2 9.7 0.0 3.0 2 1 0 2 2 1 0 AAA domain SLAC1 PF03595.17 KOG96222.1 - 1.4e-75 254.5 34.9 1.6e-75 254.4 34.9 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Pyr_redox_2 PF07992.14 KOG96223.1 - 5.3e-63 213.0 0.7 8.4e-63 212.3 0.7 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KOG96223.1 - 4.9e-35 120.1 0.7 4.2e-34 117.1 0.1 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOG96223.1 - 7.3e-21 74.5 5.4 2.6e-19 69.6 1.4 2.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOG96223.1 - 1.1e-13 51.1 6.3 9.2e-12 44.8 0.4 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KOG96223.1 - 2.9e-08 33.5 0.1 1.6e-07 31.0 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOG96223.1 - 5.2e-08 32.0 5.6 0.043 12.5 0.3 3.8 2 1 2 4 4 4 3 HI0933-like protein K_oxygenase PF13434.6 KOG96223.1 - 2.9e-06 26.7 0.0 5.3e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.21 KOG96223.1 - 6.8e-06 25.5 0.5 0.055 12.8 0.0 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 KOG96223.1 - 0.00013 21.2 0.5 0.00013 21.2 0.5 2.9 2 1 1 3 3 3 1 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 KOG96223.1 - 0.0011 18.4 0.6 0.88 8.9 0.0 3.1 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 KOG96223.1 - 0.0018 18.2 2.3 0.0061 16.5 0.1 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 KOG96223.1 - 0.0033 17.8 0.5 1.5 9.3 0.0 3.0 3 1 0 3 3 3 1 Putative NAD(P)-binding FAD_binding_3 PF01494.19 KOG96223.1 - 0.0085 15.4 1.0 1.7 7.8 0.2 2.4 2 0 0 2 2 2 2 FAD binding domain DUF1837 PF08878.11 KOG96223.1 - 0.021 14.6 1.4 0.12 12.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1837) DAO PF01266.24 KOG96223.1 - 0.024 14.2 7.8 0.055 13.0 0.4 3.1 3 0 0 3 3 3 0 FAD dependent oxidoreductase Thi4 PF01946.17 KOG96223.1 - 0.047 12.9 1.4 0.1 11.8 0.2 2.0 2 0 0 2 2 2 0 Thi4 family TPR_22 PF18833.1 KOG96223.1 - 0.11 12.6 0.2 0.23 11.6 0.2 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat NAD_binding_8 PF13450.6 KOG96223.1 - 1.3 9.3 6.9 0.076 13.2 1.0 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOG96223.1 - 2 7.4 10.9 0.03 13.4 1.6 2.6 4 0 0 4 4 4 0 FAD binding domain Ribosomal_S6e PF01092.19 KOG96224.1 - 3.3e-22 78.8 0.8 5.2e-22 78.1 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein S6e SRF-TF PF00319.18 KOG96225.1 - 1.1e-21 76.1 0.1 1.9e-21 75.3 0.1 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Aldo_ket_red PF00248.21 KOG96226.1 - 6.6e-60 202.8 0.0 8.2e-60 202.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family CNPase PF05881.12 KOG96226.1 - 0.037 13.6 0.0 0.095 12.3 0.0 1.7 2 0 0 2 2 2 0 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) Glyco_hydro_97 PF10566.9 KOG96226.1 - 0.074 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase 97 YlbE PF14003.6 KOG96226.1 - 0.66 10.5 2.5 3.3 8.2 0.3 2.5 2 0 0 2 2 2 0 YlbE-like protein Ceramidase PF05875.12 KOG96227.1 - 1.2e-88 297.0 18.3 1.4e-88 296.7 18.3 1.0 1 0 0 1 1 1 1 Ceramidase DUF5345 PF17280.2 KOG96227.1 - 0.0094 15.9 1.0 0.025 14.6 1.0 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5345) Radical_SAM_C PF16199.5 KOG96228.1 - 5.6e-33 112.8 0.0 1.2e-32 111.8 0.0 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 KOG96228.1 - 1.4e-17 64.6 0.7 5.4e-17 62.7 0.1 2.1 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 KOG96228.1 - 4.3e-10 39.8 0.1 7.7e-10 39.0 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOG96228.1 - 3.6e-06 26.9 0.0 7.9e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOG96228.1 - 0.03 14.7 0.1 0.064 13.7 0.1 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Sec16_C PF12931.7 KOG96229.1 - 3.1e-75 253.6 0.1 6.8e-75 252.5 0.0 1.7 2 0 0 2 2 2 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 KOG96229.1 - 1.8e-09 38.2 0.1 1e-08 35.8 0.1 2.4 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Sec16_N PF12935.7 KOG96229.1 - 5.7e-08 33.2 31.9 5.7e-08 33.2 31.9 5.4 4 2 1 5 5 5 1 Vesicle coat trafficking protein Sec16 N-terminus Nup96 PF12110.8 KOG96229.1 - 0.031 13.4 0.0 0.058 12.5 0.0 1.4 1 0 0 1 1 1 0 Nuclear protein 96 E3_UbLigase_RBR PF18091.1 KOG96229.1 - 0.14 12.3 0.0 0.41 10.8 0.0 1.8 1 0 0 1 1 1 0 E3 Ubiquitin Ligase RBR C-terminal domain BRO1 PF03097.18 KOG96230.1 - 2.6e-91 306.3 3.5 3.9e-91 305.8 3.5 1.3 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 KOG96230.1 - 1.2e-25 90.4 5.7 1.2e-25 90.4 5.7 2.1 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV tRNA_int_end_N2 PF12928.7 KOG96231.1 - 9.1e-17 61.0 0.0 2e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term Gly_acyl_tr_N PF06021.11 KOG96231.1 - 0.008 16.3 0.3 0.014 15.6 0.3 1.3 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase DUF3535 PF12054.8 KOG96232.1 - 1.5e-119 400.1 0.6 8.7e-119 397.6 0.8 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 KOG96232.1 - 3.2e-65 220.1 0.0 6.8e-65 219.1 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOG96232.1 - 2.9e-19 69.4 0.0 1.9e-18 66.8 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HEAT PF02985.22 KOG96232.1 - 4.7e-12 45.1 3.2 0.054 13.8 0.0 8.0 8 0 0 8 8 7 2 HEAT repeat Vac14_Fab1_bd PF12755.7 KOG96232.1 - 1.1e-06 29.2 0.1 4.4 8.0 0.0 5.9 7 0 0 7 7 5 2 Vacuolar 14 Fab1-binding region MMS19_N PF14500.6 KOG96232.1 - 4.8e-05 23.1 1.3 0.00012 21.7 0.2 2.3 2 0 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_EZ PF13513.6 KOG96232.1 - 5.1e-05 23.7 1.5 13 6.4 0.0 6.7 6 0 0 6 6 6 1 HEAT-like repeat TAF6_C PF07571.13 KOG96232.1 - 0.0026 18.1 0.0 12 6.4 0.0 4.5 3 1 0 3 3 3 1 TAF6 C-terminal HEAT repeat domain ERCC3_RAD25_C PF16203.5 KOG96232.1 - 0.012 14.8 0.0 0.032 13.5 0.0 1.7 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase UME PF08064.13 KOG96232.1 - 0.015 15.2 3.1 22 5.0 0.1 5.6 6 1 0 6 6 6 0 UME (NUC010) domain GUN4_N PF16416.5 KOG96232.1 - 0.046 13.7 0.2 0.52 10.3 0.0 2.8 2 0 0 2 2 2 0 ARM-like repeat domain, GUN4-N terminal Dopey_N PF04118.14 KOG96232.1 - 2.2 7.3 8.3 3.1 6.8 0.0 3.7 3 1 1 4 4 4 0 Dopey, N-terminal DUF2981 PF11200.8 KOG96232.1 - 2.2 7.9 6.3 4.5 6.9 6.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Ribosomal_L21e PF01157.18 KOG96234.1 - 2.8e-41 139.5 5.3 3.5e-41 139.2 3.6 1.8 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.9 KOG96234.1 - 0.024 14.2 0.0 0.028 14.0 0.0 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Mt_ATP-synt_B PF05405.14 KOG96235.1 - 6.7e-58 194.9 6.1 8.6e-58 194.6 6.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF5315 PF17242.2 KOG96236.1 - 7.8e-23 80.1 2.0 1.4e-22 79.2 2.0 1.5 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) CdvA PF18822.1 KOG96236.1 - 0.0092 15.8 0.7 0.017 14.9 0.7 1.4 1 0 0 1 1 1 1 CdvA-like coiled-coil domain Plug PF07715.15 KOG96236.1 - 0.22 12.1 1.8 0.26 11.8 0.4 1.9 2 0 0 2 2 2 0 TonB-dependent Receptor Plug Domain GPI2 PF06432.11 KOG96237.1 - 1.5e-54 185.4 26.3 1.8e-54 185.1 26.3 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase GCR1_C PF12550.8 KOG96238.1 - 4.5e-22 78.2 1.1 1.2e-21 76.7 1.1 1.8 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes NDC10_II PF16787.5 KOG96238.1 - 6.9e-07 28.6 2.5 0.0022 17.1 0.9 2.4 1 1 1 2 2 2 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 SKA2 PF16740.5 KOG96238.1 - 0.43 10.4 2.8 0.41 10.5 0.8 2.0 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Glypican PF01153.19 KOG96238.1 - 4.5 6.0 8.1 0.38 9.5 3.5 1.5 2 0 0 2 2 2 0 Glypican AAA PF00004.29 KOG96239.1 - 2.6e-41 141.1 0.0 8e-41 139.6 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG96239.1 - 6.2e-08 32.3 0.0 1.4e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 KOG96239.1 - 1.8e-06 27.8 0.0 5.8e-06 26.2 0.0 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 KOG96239.1 - 3e-05 23.8 0.0 7.2e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 KOG96239.1 - 0.00015 21.9 0.6 0.00036 20.7 0.0 2.0 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOG96239.1 - 0.00032 21.0 1.8 0.0091 16.3 0.4 3.2 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.13 KOG96239.1 - 0.00073 18.8 0.0 0.00073 18.8 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_5 PF07728.14 KOG96239.1 - 0.00078 19.5 0.0 0.0052 16.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TniB PF05621.11 KOG96239.1 - 0.00085 18.8 0.1 1.3 8.4 0.0 2.8 1 1 0 2 2 2 2 Bacterial TniB protein AAA_14 PF13173.6 KOG96239.1 - 0.0019 18.2 0.0 0.011 15.8 0.0 2.3 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 KOG96239.1 - 0.0038 16.6 0.4 0.0089 15.4 0.0 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 KOG96239.1 - 0.004 17.6 0.0 0.041 14.3 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 KOG96239.1 - 0.0062 16.3 0.1 0.022 14.5 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_25 PF13481.6 KOG96239.1 - 0.0083 15.7 0.1 0.6 9.6 0.0 2.7 2 1 1 3 3 3 1 AAA domain AAA_18 PF13238.6 KOG96239.1 - 0.017 15.7 0.0 0.017 15.7 0.0 3.0 2 2 0 2 2 1 0 AAA domain AAA_33 PF13671.6 KOG96239.1 - 0.029 14.5 0.2 0.13 12.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KOG96239.1 - 0.029 13.9 0.0 0.065 12.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region UCH PF00443.29 KOG96240.1 - 8.6e-43 146.7 8.3 2e-42 145.5 8.3 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Gp45_2 PF17470.2 KOG96240.1 - 0.2 11.6 0.9 0.96 9.5 0.1 2.6 3 0 0 3 3 3 0 Phage gene product 45.2 KH_5 PF13184.6 KOG96241.1 - 0.085 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 NusA-like KH domain VPS9 PF02204.18 KOG96242.1 - 2.7e-17 62.9 1.6 6.2e-17 61.7 1.6 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain polyprenyl_synt PF00348.17 KOG96243.1 - 1.4e-58 198.0 0.0 1.6e-58 197.8 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase DUF3605 PF12239.8 KOG96245.1 - 4.7e-37 127.7 0.0 5.7e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Arrestin_C PF02752.22 KOG96246.1 - 0.0011 19.4 10.0 0.0018 18.7 3.8 2.8 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain VPS28 PF03997.12 KOG96247.1 - 8.6e-72 240.8 5.5 1e-71 240.6 5.5 1.0 1 0 0 1 1 1 1 VPS28 protein DUF3114 PF11311.8 KOG96247.1 - 0.0043 16.6 0.6 0.22 11.0 0.3 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3114) DUF3417 PF11897.8 KOG96247.1 - 0.016 15.6 0.4 0.035 14.6 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3417) Pro_isomerase PF00160.21 KOG96248.1 - 2e-09 37.9 0.0 4.2e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD NIF PF03031.18 KOG96249.1 - 6.3e-43 146.2 0.1 9.8e-43 145.6 0.1 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase NeA_P2 PF12312.8 KOG96249.1 - 0.15 11.5 0.5 0.25 10.8 0.5 1.3 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein DUF1764 PF08576.10 KOG96249.1 - 9.8 7.1 10.5 10 7.1 0.7 2.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Aldedh PF00171.22 KOG96250.1 - 2.2e-172 573.7 0.1 2.5e-172 573.6 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family FliD_C PF07195.12 KOG96250.1 - 0.011 15.2 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus CorA PF01544.18 KOG96251.1 - 0.0026 17.1 9.2 0.0064 15.8 9.2 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Glutaredoxin PF00462.24 KOG96252.1 - 8.7e-17 61.1 0.0 1.4e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin ABC2_membrane PF01061.24 KOG96253.1 - 1.7e-66 223.6 46.3 5.8e-35 120.6 12.6 2.8 3 0 0 3 3 2 2 ABC-2 type transporter ABC_tran PF00005.27 KOG96253.1 - 3e-35 121.7 0.0 1.1e-16 61.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 KOG96253.1 - 1.1e-33 115.0 5.3 1.4e-27 95.4 0.1 2.9 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 KOG96253.1 - 2.2e-10 41.0 0.0 5.4e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 KOG96253.1 - 8.8e-07 29.0 0.0 8.5e-05 22.5 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 KOG96253.1 - 1.6e-05 25.4 0.1 0.0014 19.1 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 KOG96253.1 - 5.2e-05 22.8 0.0 0.37 10.2 0.0 3.1 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 KOG96253.1 - 0.00049 20.2 0.1 0.64 10.1 0.1 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase ABC2_membrane_3 PF12698.7 KOG96253.1 - 0.0005 19.3 9.5 0.0005 19.3 9.5 3.4 3 0 0 3 3 3 1 ABC-2 family transporter protein AAA_22 PF13401.6 KOG96253.1 - 0.0016 18.7 0.1 0.072 13.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 KOG96253.1 - 0.0018 18.2 0.0 1.4 8.7 0.0 2.4 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 KOG96253.1 - 0.0018 18.8 0.0 0.055 14.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KOG96253.1 - 0.002 17.8 0.2 0.098 12.4 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 KOG96253.1 - 0.0032 17.0 0.0 0.21 11.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 KOG96253.1 - 0.0087 16.0 0.0 0.086 12.8 0.0 2.4 2 0 0 2 2 2 1 NACHT domain cobW PF02492.19 KOG96253.1 - 0.017 14.7 0.2 0.05 13.2 0.1 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 KOG96253.1 - 0.017 14.8 0.4 0.88 9.3 0.1 2.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KOG96253.1 - 0.036 13.3 0.0 0.81 8.9 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin TsaE PF02367.17 KOG96253.1 - 0.038 14.0 0.1 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 KOG96253.1 - 0.042 14.2 0.7 2 8.8 0.0 3.1 3 0 0 3 3 3 0 RNA helicase AAA_33 PF13671.6 KOG96253.1 - 0.07 13.3 0.1 1.4 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 KOG96253.1 - 0.086 12.7 0.0 14 5.5 0.0 3.4 3 0 0 3 3 3 0 NTPase Ploopntkinase3 PF18751.1 KOG96253.1 - 0.13 12.2 0.1 12 5.7 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_23 PF13476.6 KOG96253.1 - 0.13 12.7 0.0 0.49 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain Gly_transf_sug PF04488.15 KOG96254.1 - 5.7e-24 84.6 0.0 1.4e-23 83.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Lge1 PF11488.8 KOG96255.1 - 6.8e-19 67.8 3.3 1e-18 67.3 3.3 1.3 1 0 0 1 1 1 1 Transcriptional regulatory protein LGE1 zf-CCCH PF00642.24 KOG96256.1 - 3.6e-11 42.7 11.8 4.9e-06 26.3 3.2 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOG96256.1 - 2.1e-10 40.3 22.4 7.5e-06 25.8 3.7 2.8 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_4 PF18044.1 KOG96256.1 - 4.8e-10 39.0 12.8 8.1e-06 25.5 4.6 2.6 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 KOG96256.1 - 2.4e-07 31.4 12.8 0.00022 21.9 0.4 3.1 2 1 1 3 3 3 2 Torus domain zf-CCCH_3 PF15663.5 KOG96256.1 - 0.00017 21.7 0.4 0.00035 20.8 0.4 1.7 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 KOG96256.1 - 0.016 15.6 21.8 0.18 12.3 4.4 3.0 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger Glyco_transf_15 PF01793.16 KOG96257.1 - 2.1e-128 428.1 11.6 2.7e-128 427.8 11.6 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Arf PF00025.21 KOG96258.1 - 4.4e-48 163.0 0.3 5.4e-48 162.7 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 KOG96258.1 - 2.6e-15 56.4 0.0 3.1e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 KOG96258.1 - 1e-12 47.9 0.9 1.1e-07 31.3 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 KOG96258.1 - 1.6e-12 47.3 0.1 2e-12 46.9 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KOG96258.1 - 2.4e-12 47.1 0.0 3.6e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KOG96258.1 - 2.6e-08 33.5 0.1 3.2e-08 33.2 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOG96258.1 - 2.3e-07 30.5 0.1 5.9e-06 26.0 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOG96258.1 - 6.6e-07 29.4 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG96258.1 - 0.013 15.5 0.1 1.4 8.8 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 KOG96258.1 - 0.013 15.8 0.1 0.065 13.5 0.1 2.1 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.6 KOG96258.1 - 0.028 15.0 0.3 0.13 12.8 0.3 2.0 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KOG96258.1 - 0.042 13.6 0.1 0.061 13.0 0.1 1.4 1 1 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 KOG96258.1 - 0.076 12.7 0.2 0.15 11.7 0.0 1.6 2 0 0 2 2 2 0 Thymidylate kinase Septin PF00735.18 KOG96258.1 - 0.086 12.1 0.3 0.81 8.9 0.0 2.0 2 0 0 2 2 2 0 Septin Anp1 PF03452.14 KOG96259.1 - 4.1e-107 357.5 0.3 5e-107 357.2 0.3 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 KOG96259.1 - 0.0058 16.5 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 EF1G PF00647.19 KOG96261.1 - 2e-44 150.0 0.3 4.6e-44 148.9 0.0 1.8 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.20 KOG96261.1 - 7.6e-15 55.0 0.1 2.2e-14 53.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KOG96261.1 - 4.9e-13 49.1 0.0 1.1e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOG96261.1 - 5.2e-07 29.6 0.2 1.3e-06 28.3 0.2 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOG96261.1 - 0.0006 20.0 0.0 0.0013 18.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOG96261.1 - 0.0015 18.9 0.0 0.0041 17.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Sgf11_N PF18519.1 KOG96262.1 - 2.8e-23 81.2 2.8 4.4e-23 80.6 2.8 1.3 1 0 0 1 1 1 1 SAGA-associated factor 11 N-terminal domain Sgf11 PF08209.11 KOG96262.1 - 1.1e-15 56.8 3.8 1.6e-15 56.4 3.8 1.2 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) zf_C2H2_13 PF18508.1 KOG96262.1 - 0.00068 19.2 1.0 0.00089 18.8 0.2 1.6 2 0 0 2 2 2 1 Zinc finger domain zf-C2HC_2 PF13913.6 KOG96262.1 - 0.0031 17.4 0.2 0.0041 17.0 0.2 1.2 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-CpG_bind_C PF12269.8 KOG96262.1 - 0.0073 16.1 0.0 0.0073 16.1 0.0 1.2 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain zf_Rg PF17915.1 KOG96262.1 - 0.1 12.0 0.3 0.19 11.1 0.3 1.4 1 0 0 1 1 1 0 Reverse gyrase zinc finger Skp1_POZ PF03931.15 KOG96263.1 - 1.6e-19 69.9 0.5 2.1e-19 69.5 0.1 1.4 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.31 KOG96263.1 - 0.0023 18.2 0.1 0.0073 16.5 0.1 1.7 1 1 0 1 1 1 1 BTB/POZ domain Vps16_N PF04841.13 KOG96264.1 - 2.6e-123 411.8 0.2 4.1e-123 411.2 0.2 1.3 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 KOG96264.1 - 1.2e-122 409.0 10.6 1.7e-122 408.5 10.6 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region RRM_1 PF00076.22 KOG96265.1 - 2.2e-55 184.4 1.0 1.8e-19 69.3 0.2 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOG96265.1 - 3.9e-08 33.3 0.4 0.0058 16.7 0.0 3.9 4 0 0 4 4 4 2 RNA recognition motif FYDLN_acid PF09538.10 KOG96265.1 - 3.6 8.3 30.6 2.8 8.7 4.2 3.9 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) Pkinase PF00069.25 KOG96266.1 - 1.7e-54 184.9 0.3 2.1e-53 181.4 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96266.1 - 1.7e-23 83.2 0.1 1.3e-22 80.4 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOG96266.1 - 0.028 13.4 0.0 0.045 12.7 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KOG96266.1 - 0.087 12.7 0.1 0.18 11.7 0.1 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family FLILHELTA PF10306.9 KOG96267.1 - 5.6e-23 81.1 0.1 9.3e-23 80.4 0.1 1.4 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA tRNA-synt_1 PF00133.22 KOG96268.1 - 7.1e-152 506.7 0.1 1e-151 506.2 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KOG96268.1 - 4.7e-20 72.1 0.7 1.1e-19 70.9 0.7 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KOG96268.1 - 5.2e-19 68.3 2.2 2.9e-11 42.7 0.0 4.3 4 0 0 4 4 4 3 tRNA synthetases class I (M) DZR PF12773.7 KOG96268.1 - 0.075 13.1 1.1 0.15 12.1 1.1 1.4 1 0 0 1 1 1 0 Double zinc ribbon RNA_pol_Rpb1_7 PF04990.12 KOG96269.1 - 0.079 13.0 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 7 zf-C2H2 PF00096.26 KOG96270.1 - 1.4e-09 37.9 7.4 0.00024 21.4 1.6 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG96270.1 - 3.8e-07 30.4 6.4 0.0074 17.0 0.2 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 KOG96270.1 - 0.0043 17.7 2.1 0.033 14.8 0.5 2.2 1 1 1 2 2 2 1 Zinc finger C2H2-type, 3 repeats C1_4 PF07975.12 KOG96270.1 - 0.0044 17.2 1.7 0.097 12.9 0.1 2.3 2 0 0 2 2 2 1 TFIIH C1-like domain zf-H2C2_2 PF13465.6 KOG96270.1 - 0.0058 17.0 3.4 0.02 15.3 0.2 2.7 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_11 PF16622.5 KOG96270.1 - 0.022 14.5 9.6 0.39 10.5 1.6 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_3 PF13878.6 KOG96270.1 - 0.048 13.5 1.7 0.12 12.2 0.3 2.2 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO zf-C2H2_jaz PF12171.8 KOG96270.1 - 0.074 13.4 5.3 1.5 9.2 0.0 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 KOG96270.1 - 0.09 12.4 1.1 5.9 6.6 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Zn_ribbon_recom PF13408.6 KOG96270.1 - 0.14 12.7 2.1 0.82 10.2 0.6 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Zn_ribbon_SprT PF17283.2 KOG96270.1 - 0.15 12.0 3.5 0.11 12.4 1.4 1.9 1 1 1 2 2 2 0 SprT-like zinc ribbon domain zf-LYAR PF08790.11 KOG96270.1 - 0.16 11.9 2.1 9.6 6.2 0.1 2.4 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.10 KOG96270.1 - 0.22 11.6 1.5 0.72 10.0 0.9 2.1 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2H2_6 PF13912.6 KOG96270.1 - 0.32 11.0 0.3 0.32 11.0 0.3 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger C1_1 PF00130.22 KOG96270.1 - 0.44 10.5 4.5 5.9 6.9 0.1 2.4 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RIG-I_C-RD PF11648.8 KOG96270.1 - 0.6 10.4 5.6 29 4.9 6.7 2.5 1 1 1 2 2 2 0 C-terminal domain of RIG-I HypA PF01155.19 KOG96270.1 - 0.83 9.7 4.1 3.1 7.8 4.0 1.9 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA LIM PF00412.22 KOG96270.1 - 1.1 9.6 4.8 16 5.8 5.0 2.3 1 1 1 2 2 2 0 LIM domain zf-H2C2_5 PF13909.6 KOG96270.1 - 1.1 9.1 4.5 8.6 6.2 1.0 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain NAC PF01849.18 KOG96271.1 - 1.2e-16 60.4 0.2 2.5e-16 59.4 0.2 1.6 1 0 0 1 1 1 1 NAC domain Ribosomal_60s PF00428.19 KOG96271.1 - 0.017 15.7 2.5 0.029 14.9 0.2 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Glyco_hydro_20b PF02838.15 KOG96271.1 - 0.019 15.8 0.2 0.082 13.7 0.1 1.9 2 0 0 2 2 2 0 Glycosyl hydrolase family 20, domain 2 E1-E2_ATPase PF00122.20 KOG96272.1 - 5.4e-48 162.9 3.9 2.8e-47 160.6 3.5 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KOG96272.1 - 4e-19 69.7 0.1 1.1e-18 68.3 0.1 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOG96272.1 - 2e-10 40.2 0.0 5.7e-10 38.7 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOG96272.1 - 0.0019 18.0 0.1 0.0048 16.7 0.1 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOG96272.1 - 0.0063 16.6 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) DUF4392 PF14336.6 KOG96272.1 - 0.047 13.1 0.0 0.085 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) T5orf172 PF10544.9 KOG96273.1 - 1.5e-08 35.1 0.1 1.8e-05 25.2 0.1 2.3 1 1 0 1 1 1 1 T5orf172 domain MUG113 PF13455.6 KOG96273.1 - 1.4e-07 32.1 0.1 1.4e-06 28.9 0.1 2.2 1 1 0 1 1 1 1 Meiotically up-regulated gene 113 adh_short PF00106.25 KOG96274.1 - 1.9e-08 34.0 0.0 2.7e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase ApbA_C PF08546.11 KOG96275.1 - 1.1e-06 28.8 1.5 2.2e-06 27.9 0.0 2.3 3 0 0 3 3 3 1 Ketopantoate reductase PanE/ApbA C terminal DUF743 PF05332.11 KOG96275.1 - 0.17 11.9 3.7 0.48 10.5 2.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF743) ISG65-75 PF11727.8 KOG96275.1 - 0.66 9.2 14.9 1.2 8.3 14.9 1.4 1 0 0 1 1 1 0 Invariant surface glycoprotein Pkinase PF00069.25 KOG96276.1 - 1.2e-60 205.1 0.0 1.4e-60 204.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96276.1 - 1.3e-27 96.7 0.0 1.8e-27 96.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOG96276.1 - 0.011 14.7 0.0 0.015 14.3 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 KOG96276.1 - 0.012 15.0 0.0 0.017 14.4 0.0 1.3 1 1 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.11 KOG96276.1 - 0.054 12.5 0.0 0.082 11.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 KOG96276.1 - 0.071 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family AdoMet_MTase PF07757.13 KOG96277.1 - 6.6e-42 142.4 0.1 1.2e-41 141.5 0.1 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_31 PF13847.6 KOG96277.1 - 0.0025 17.7 0.0 0.0052 16.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOG96277.1 - 0.2 11.6 0.2 3.2 7.7 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain SUV3_C PF12513.8 KOG96278.1 - 1e-17 63.8 1.2 2.8e-17 62.4 1.2 1.8 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 KOG96278.1 - 1.2e-12 48.1 0.0 3e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TcpS PF17456.2 KOG96278.1 - 0.017 15.2 1.9 0.054 13.6 0.3 2.3 2 0 0 2 2 2 0 Toxin-coregulated pilus protein S Thiolase_N PF00108.23 KOG96279.1 - 3.6e-95 318.2 2.2 4.4e-95 317.9 2.2 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KOG96279.1 - 1.3e-45 154.0 0.7 3.2e-45 152.7 0.2 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KOG96279.1 - 2.9e-06 27.1 2.2 6.8e-06 25.8 2.2 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain CBP4 PF07960.11 KOG96280.1 - 0.016 15.0 0.2 0.039 13.8 0.2 1.6 1 0 0 1 1 1 0 CBP4 Pkinase PF00069.25 KOG96281.1 - 4.6e-44 150.8 2.9 1.2e-37 129.8 1.3 2.4 1 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96281.1 - 1.8e-19 70.1 0.4 3.5e-18 65.8 0.1 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG96281.1 - 5.7e-05 22.6 0.0 0.00012 21.5 0.0 1.6 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 KOG96281.1 - 0.00026 20.7 0.7 0.29 10.7 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KOG96281.1 - 0.015 15.2 0.3 0.038 13.9 0.2 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 KOG96281.1 - 0.076 12.4 0.5 0.12 11.7 0.5 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RMI1_N PF08585.12 KOG96282.1 - 1.6e-16 60.7 0.1 2.1e-16 60.4 0.1 1.2 1 0 0 1 1 1 1 RecQ mediated genome instability protein Spo7_2_N PF15407.6 KOG96282.1 - 0.066 12.9 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 Sporulation protein family 7 MTHFR PF02219.17 KOG96283.1 - 1.2e-113 379.2 0.0 1.6e-113 378.8 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase ERCC4 PF02732.15 KOG96284.1 - 1.6e-20 73.9 2.9 2.5e-20 73.3 0.0 2.7 3 0 0 3 3 3 1 ERCC4 domain GATA PF00320.27 KOG96285.1 - 3.2e-15 55.4 2.8 7.5e-15 54.2 2.8 1.7 1 0 0 1 1 1 1 GATA zinc finger zf-like PF04071.12 KOG96285.1 - 0.069 13.1 0.9 0.12 12.3 0.9 1.4 1 0 0 1 1 1 0 Cysteine-rich small domain zf-C2H2_3 PF13878.6 KOG96285.1 - 0.072 12.9 0.5 10 6.0 0.0 2.7 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO DUF4379 PF14311.6 KOG96285.1 - 1.6 9.2 5.7 6.9 7.1 0.6 2.4 2 0 0 2 2 2 0 Probable Zinc-ribbon domain Peptidase_C48 PF02902.19 KOG96286.1 - 1.1e-42 146.3 0.4 1.1e-42 146.3 0.4 2.3 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain VTC PF09359.10 KOG96287.1 - 2.1e-96 322.6 4.9 4.5e-96 321.5 4.9 1.6 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 KOG96287.1 - 1.2e-10 41.7 1.9 1.2e-10 41.7 1.9 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 KOG96287.1 - 3.7e-07 30.4 30.6 0.0075 16.2 1.5 4.8 3 1 2 5 5 5 3 SPX domain ANAPC4 PF12896.7 KOG96287.1 - 0.0043 16.6 0.3 0.69 9.4 0.0 2.8 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 4 Pyr_redox_2 PF07992.14 KOG96289.1 - 2.2e-43 148.6 0.0 2.7e-43 148.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KOG96289.1 - 7.3e-28 97.0 0.0 4.9e-26 91.1 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOG96289.1 - 1.7e-17 63.7 0.6 2.6e-16 59.9 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KOG96289.1 - 2.2e-09 37.2 0.1 6.1e-09 35.7 0.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 KOG96289.1 - 4e-09 36.1 0.7 2.5e-06 27.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOG96289.1 - 2.5e-06 27.6 4.2 0.0032 17.7 0.6 3.3 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KOG96289.1 - 4.7e-06 26.0 0.4 0.00024 20.4 0.1 2.4 2 1 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 KOG96289.1 - 1.7e-05 24.2 1.7 0.011 15.0 0.2 2.5 3 0 0 3 3 3 2 FAD binding domain HI0933_like PF03486.14 KOG96289.1 - 3.7e-05 22.6 3.0 0.014 14.1 0.1 3.6 3 1 1 4 4 4 1 HI0933-like protein FAD_binding_2 PF00890.24 KOG96289.1 - 7e-05 22.1 1.7 0.00011 21.4 0.9 1.7 2 0 0 2 2 2 1 FAD binding domain 3HCDH_N PF02737.18 KOG96289.1 - 8.1e-05 22.6 1.5 0.00082 19.3 0.1 2.5 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 KOG96289.1 - 0.0003 20.0 4.5 0.018 14.1 0.4 3.0 3 0 0 3 3 3 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 KOG96289.1 - 0.00051 19.4 1.4 0.1 11.9 0.0 3.0 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 KOG96289.1 - 0.0029 16.7 0.6 0.023 13.7 0.2 2.3 2 1 0 2 2 2 1 Lycopene cyclase protein XdhC_C PF13478.6 KOG96289.1 - 0.0031 18.0 0.1 2.8 8.5 0.0 3.2 2 2 0 2 2 2 1 XdhC Rossmann domain K_oxygenase PF13434.6 KOG96289.1 - 0.0033 16.6 0.7 1.5 7.9 0.1 3.0 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) 2-Hacid_dh_C PF02826.19 KOG96289.1 - 0.0087 15.4 0.2 0.039 13.3 0.0 2.0 2 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 KOG96289.1 - 0.011 16.0 0.1 0.11 12.7 0.0 2.5 2 1 0 2 2 2 0 TrkA-N domain DAO PF01266.24 KOG96289.1 - 0.015 14.9 7.6 6 6.3 0.8 3.8 1 1 3 4 4 4 0 FAD dependent oxidoreductase ARID PF01388.21 KOG96290.1 - 1.2e-17 64.3 0.3 1.2e-17 64.3 0.3 2.9 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain SIR2 PF02146.17 KOG96291.1 - 3.7e-51 173.6 0.0 1.3e-49 168.5 0.0 2.3 1 1 0 1 1 1 1 Sir2 family DUF4745 PF15923.5 KOG96291.1 - 0.11 12.5 0.1 0.19 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4745) zf-CRD PF17979.1 KOG96291.1 - 0.13 12.3 1.8 0.27 11.3 1.8 1.4 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions Ribosomal_S16 PF00886.19 KOG96293.1 - 7.4e-27 93.2 0.1 1e-26 92.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 PDR_assoc PF08370.11 KOG96293.1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Plant PDR ABC transporter associated NUC173 PF08161.12 KOG96294.1 - 7.5e-70 234.7 0.4 3.4e-67 226.1 0.3 3.7 3 0 0 3 3 3 1 NUC173 domain Cnd1 PF12717.7 KOG96294.1 - 0.011 15.8 11.3 0.011 15.8 0.1 4.7 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 BEN PF10523.9 KOG96294.1 - 0.019 15.2 1.0 2 8.7 0.0 4.2 4 1 1 5 5 5 0 BEN domain HEAT PF02985.22 KOG96294.1 - 0.12 12.7 2.7 1e+02 3.5 0.0 5.0 6 0 0 6 6 6 0 HEAT repeat UME PF08064.13 KOG96294.1 - 0.79 9.7 4.6 2.1 8.3 0.1 3.9 4 1 0 4 4 4 0 UME (NUC010) domain Bromo_TP PF07524.13 KOG96295.1 - 7.1e-09 35.6 0.0 1.7e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated Clat_adaptor_s PF01217.20 KOG96296.1 - 1.5e-17 63.9 0.5 2.2e-17 63.3 0.5 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain NFACT-C PF11923.8 KOG96297.1 - 3.6e-32 110.4 1.0 3.6e-32 110.4 1.0 4.4 4 0 0 4 4 4 1 NFACT protein C-terminal domain FbpA PF05833.11 KOG96297.1 - 4.4e-23 81.8 29.5 4.4e-23 81.8 29.5 3.6 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 KOG96297.1 - 4.9e-18 65.8 0.0 2e-17 63.8 0.0 2.2 1 0 0 1 1 1 1 NFACT protein RNA binding domain SDA1 PF05285.12 KOG96297.1 - 0.0014 18.1 56.8 0.0014 18.1 56.8 3.7 3 1 0 3 3 3 1 SDA1 FHIPEP PF00771.20 KOG96297.1 - 0.93 7.9 4.8 0.4 9.1 1.0 2.4 2 0 0 2 2 2 0 FHIPEP family DEAD_2 PF06733.15 KOG96298.1 - 4.5e-53 179.5 0.8 1e-52 178.3 0.0 1.9 2 0 0 2 2 2 1 DEAD_2 Helicase_C_2 PF13307.6 KOG96298.1 - 2.2e-49 167.9 0.1 5.4e-49 166.7 0.1 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 KOG96298.1 - 0.00057 19.9 5.9 0.29 11.1 4.4 3.1 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 KOG96298.1 - 0.011 15.5 2.0 0.74 9.6 0.4 2.7 2 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_22 PF13401.6 KOG96298.1 - 0.012 15.9 0.1 2.9 8.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KOG96298.1 - 0.068 12.9 0.1 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 KOG96298.1 - 0.12 11.8 1.6 1.8 8.0 0.1 2.5 2 0 0 2 2 2 0 PhoH-like protein zf-TFIIIC PF12660.7 KOG96299.1 - 1.3e-07 31.5 0.0 3.3e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex ANAPC4_WD40 PF12894.7 KOG96299.1 - 9e-06 25.9 0.0 0.00015 22.0 0.0 3.0 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain NPC1_N PF16414.5 KOG96300.1 - 2.5e-82 276.1 13.7 2.5e-82 276.1 13.7 1.6 2 0 0 2 2 2 1 Niemann-Pick C1 N terminus Patched PF02460.18 KOG96300.1 - 1.7e-66 224.9 9.7 6.3e-36 123.8 2.6 2.3 1 1 1 2 2 2 2 Patched family Sterol-sensing PF12349.8 KOG96300.1 - 5.3e-41 140.0 4.4 5.3e-41 140.0 4.4 2.9 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 KOG96300.1 - 9.2e-07 26.9 24.9 1.4e-06 26.3 18.5 2.5 3 0 0 3 3 3 2 AcrB/AcrD/AcrF family TMEM18 PF14770.6 KOG96300.1 - 0.16 12.0 0.1 0.16 12.0 0.1 4.2 3 1 1 4 4 4 0 Transmembrane protein 18 PPR_2 PF13041.6 KOG96301.1 - 6.7e-14 51.8 3.6 2.2e-06 27.8 0.0 4.2 4 0 0 4 4 4 2 PPR repeat family PPR_3 PF13812.6 KOG96301.1 - 1.8e-08 34.3 0.9 0.00015 21.8 0.0 3.6 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 KOG96301.1 - 0.0024 17.5 0.0 0.19 11.5 0.0 3.3 3 0 0 3 3 3 1 PPR repeat PPR_long PF17177.4 KOG96301.1 - 0.099 12.0 0.0 2.1 7.6 0.0 2.3 2 0 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP Pil1 PF13805.6 KOG96302.1 - 4.7e-125 416.4 0.5 5.7e-125 416.1 0.5 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 PCP_red PF08369.10 KOG96302.1 - 0.038 14.2 0.3 0.17 12.1 0.3 2.1 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit ThiF PF00899.21 KOG96303.1 - 5.8e-05 22.6 0.0 0.027 13.8 0.0 2.5 2 1 0 2 2 2 2 ThiF family EAP30 PF04157.16 KOG96304.1 - 6.8e-53 179.4 0.0 7.6e-53 179.2 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Hat1_N PF10394.9 KOG96305.1 - 3.1e-41 141.3 1.3 5.3e-41 140.5 1.3 1.4 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 KOG96305.1 - 1.2e-07 32.0 0.0 2.6e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOG96305.1 - 0.052 13.5 0.0 0.19 11.7 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOG96305.1 - 0.13 12.7 0.0 0.26 11.8 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Citrate_synt PF00285.21 KOG96306.1 - 1.4e-91 307.3 0.0 1.7e-91 307.0 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain RVT_2 PF07727.14 KOG96307.1 - 2.8e-31 109.0 0.4 5.5e-31 108.0 0.4 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KOG96307.1 - 3.5e-16 59.4 0.0 7e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MafB19-deam PF14437.6 KOG96307.1 - 0.092 12.5 0.1 2 8.2 0.0 2.3 2 0 0 2 2 2 0 MafB19-like deaminase Sulfate_transp PF00916.20 KOG96308.1 - 4.9e-103 344.8 21.8 6.2e-103 344.5 21.8 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 KOG96308.1 - 3e-23 81.7 0.1 8.3e-23 80.3 0.1 1.7 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 KOG96308.1 - 0.00012 22.5 7.0 0.00012 22.5 7.0 3.1 4 1 0 4 4 4 1 Molybdate transporter of MFS superfamily Spore_YabQ PF09578.10 KOG96308.1 - 0.49 10.7 11.3 2.2 8.5 1.3 3.4 2 1 1 3 3 3 0 Spore cortex protein YabQ (Spore_YabQ) DUF1072 PF06380.11 KOG96308.1 - 1.4 8.8 3.9 3.1 7.8 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1072) ETF PF01012.21 KOG96309.1 - 1.8e-34 119.2 0.0 3.7e-34 118.2 0.0 1.5 2 0 0 2 2 2 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 KOG96309.1 - 5.6e-30 103.2 0.0 1e-29 102.4 0.0 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain DUF4671 PF15710.5 KOG96309.1 - 0.19 10.5 0.0 0.25 10.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4671) HeH PF12949.7 KOG96310.1 - 0.026 14.3 0.0 8.8 6.1 0.0 2.6 2 0 0 2 2 2 0 HeH/LEM domain Stathmin PF00836.19 KOG96310.1 - 0.13 12.2 5.5 0.22 11.5 5.5 1.3 1 0 0 1 1 1 0 Stathmin family ICL PF00463.21 KOG96311.1 - 3.4e-169 563.7 0.0 3.9e-169 563.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 KOG96311.1 - 3.7e-07 29.8 0.0 5.8e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Rad21_Rec8_N PF04825.13 KOG96312.1 - 7.7e-16 58.2 0.5 2.6e-15 56.5 0.5 1.8 1 1 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 KOG96312.1 - 0.033 13.5 0.0 0.1 11.9 0.0 1.8 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein Copper-fist PF00649.18 KOG96313.1 - 1.5e-21 75.6 0.7 3.8e-21 74.3 0.7 1.7 1 0 0 1 1 1 1 Copper fist DNA binding domain Zn_clus PF00172.18 KOG96314.1 - 0.00068 19.7 11.0 0.0014 18.7 2.8 2.6 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain RNA_pol_Rpb2_6 PF00562.28 KOG96315.1 - 1e-114 383.7 0.0 2.2e-114 382.6 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 KOG96315.1 - 6.4e-52 176.0 0.1 9.2e-52 175.5 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 KOG96315.1 - 4.3e-39 134.1 0.0 1.3e-38 132.6 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 KOG96315.1 - 4.6e-28 97.2 0.0 1.5e-27 95.5 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 KOG96315.1 - 2.6e-23 81.8 0.0 5.2e-23 80.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 KOG96315.1 - 2.1e-16 60.1 0.0 6.5e-15 55.3 0.0 2.7 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 Mito_carr PF00153.27 KOG96317.1 - 3.2e-74 244.9 2.1 2.3e-27 94.7 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOG96317.1 - 1.2e-05 24.6 1.7 0.26 10.4 0.0 3.9 3 1 1 4 4 4 3 Gammaproteobacterial serine protease zf-C2H2 PF00096.26 KOG96318.1 - 1.6e-09 37.6 9.0 0.00038 20.8 1.4 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG96318.1 - 3.8e-06 27.3 9.7 0.009 16.8 1.0 2.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 KOG96318.1 - 0.00077 19.8 5.4 0.012 16.0 0.4 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 KOG96318.1 - 0.0019 18.6 0.4 0.0019 18.6 0.4 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KOG96318.1 - 0.0061 16.8 3.4 0.52 10.7 0.0 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 KOG96318.1 - 0.14 12.8 2.5 0.17 12.5 0.2 2.2 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 KOG96318.1 - 2.5 7.9 7.6 13 5.6 0.0 2.9 2 1 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 KOG96319.1 - 9.7e-11 41.5 12.1 5.7e-05 23.4 1.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG96319.1 - 3.8e-07 30.4 10.8 0.0026 18.5 1.2 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOG96319.1 - 1.4e-06 28.5 10.2 0.00022 21.5 1.3 3.9 3 1 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.7 KOG96319.1 - 0.00015 22.1 6.3 0.0078 16.6 0.3 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KOG96319.1 - 0.0024 18.1 6.5 0.7 10.3 0.0 2.9 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 KOG96319.1 - 0.23 11.5 8.8 2.9 8.0 0.5 2.5 1 1 1 2 2 2 0 BED zinc finger zf-C2HC_2 PF13913.6 KOG96319.1 - 2.6 8.1 6.9 19 5.3 0.3 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type eIF-6 PF01912.18 KOG96320.1 - 6.1e-82 273.8 0.4 7.7e-82 273.5 0.4 1.1 1 0 0 1 1 1 1 eIF-6 family Mss4 PF04421.13 KOG96321.1 - 1.3e-23 82.9 0.0 1.7e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Mss4 protein CAF1A PF12253.8 KOG96322.1 - 1.1e-21 76.7 6.8 1.1e-21 76.7 6.8 3.3 2 1 0 2 2 2 1 Chromatin assembly factor 1 subunit A SdrD_B PF17210.3 KOG96322.1 - 0.086 13.1 0.1 0.086 13.1 0.1 2.7 2 1 1 3 3 3 0 SdrD B-like domain Hamartin PF04388.12 KOG96322.1 - 2.7 6.5 32.0 1.7 7.2 0.5 2.2 2 0 0 2 2 2 0 Hamartin protein MCM PF00493.23 KOG96323.1 - 1.2e-101 338.5 0.0 1.9e-101 337.9 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KOG96323.1 - 1.4e-36 125.1 0.3 2.6e-36 124.2 0.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KOG96323.1 - 5.5e-28 97.2 2.7 5.5e-28 97.2 2.7 2.1 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 KOG96323.1 - 1.4e-18 67.4 5.2 7.6e-18 65.0 5.2 2.4 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 KOG96323.1 - 9.8e-07 28.8 0.0 2.2e-05 24.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KOG96323.1 - 9.5e-06 25.1 0.0 0.00034 20.0 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KOG96323.1 - 0.0014 18.5 0.0 0.0051 16.7 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOG96323.1 - 0.0032 17.9 1.3 1.4 9.3 0.0 3.5 3 1 0 3 3 3 1 AAA ATPase domain Sigma54_activat PF00158.26 KOG96323.1 - 0.12 12.1 0.1 4.4 7.0 0.0 3.2 3 0 0 3 3 3 0 Sigma-54 interaction domain CH PF00307.31 KOG96323.1 - 0.14 12.3 0.3 3.6 7.8 0.1 2.5 2 0 0 2 2 2 0 Calponin homology (CH) domain ATP-synt_G PF04718.15 KOG96324.1 - 5e-31 107.5 0.8 5.9e-31 107.3 0.8 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit Mito_carr PF00153.27 KOG96325.1 - 1.4e-72 239.6 0.6 6.7e-25 86.8 0.0 3.6 4 0 0 4 4 4 3 Mitochondrial carrier protein HMD PF03201.16 KOG96325.1 - 0.028 14.6 0.1 37 4.6 0.0 3.4 3 0 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Vps4_C PF09336.10 KOG96325.1 - 0.068 13.2 0.6 41 4.3 0.0 3.7 4 0 0 4 4 4 0 Vps4 C terminal oligomerisation domain Serine_protease PF18405.1 KOG96325.1 - 0.071 12.3 0.0 2.2 7.4 0.0 3.0 3 0 0 3 3 3 0 Gammaproteobacterial serine protease EF-hand_8 PF13833.6 KOG96325.1 - 0.088 12.7 0.0 5.3 7.0 0.0 3.2 2 0 0 2 2 2 0 EF-hand domain pair Fungal_trans PF04082.18 KOG96326.1 - 1.7e-75 253.5 3.2 1.7e-75 253.5 3.2 2.6 2 1 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 KOG96326.1 - 6.3e-07 29.5 11.5 0.0017 18.7 4.7 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG96326.1 - 2.5e-05 24.7 9.0 0.023 15.5 3.6 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOG96326.1 - 0.27 11.3 5.2 1.6 8.8 1.7 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 KOG96326.1 - 0.57 10.5 10.8 0.17 12.2 0.6 3.7 3 1 1 4 4 4 0 C2H2-type zinc ribbon MRG PF05712.13 KOG96327.1 - 4.5e-44 150.1 0.9 7.8e-44 149.4 0.9 1.3 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 KOG96327.1 - 3.8e-06 26.7 0.2 1.2e-05 25.1 0.2 1.9 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain Peptidase_M41 PF01434.18 KOG96328.1 - 9.7e-61 204.9 0.1 1.6e-60 204.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KOG96328.1 - 1.4e-40 138.7 0.0 3.1e-40 137.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG96328.1 - 1.8e-08 34.0 0.0 6.4e-08 32.3 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KOG96328.1 - 1.3e-05 25.6 0.4 8.6e-05 23.0 0.4 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOG96328.1 - 0.00023 21.5 0.2 0.095 13.0 0.2 2.9 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 KOG96328.1 - 0.00024 20.4 0.0 0.00047 19.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 KOG96328.1 - 0.00066 19.5 0.0 0.0052 16.5 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KOG96328.1 - 0.004 17.1 0.1 0.013 15.5 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KOG96328.1 - 0.016 15.8 0.1 0.28 11.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain SpoU_sub_bind PF08032.12 KOG96328.1 - 0.019 15.2 0.2 19 5.6 0.4 3.3 3 0 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding IstB_IS21 PF01695.17 KOG96328.1 - 0.025 14.3 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 KOG96328.1 - 0.038 14.2 0.0 0.19 11.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 KOG96328.1 - 0.054 12.9 0.2 0.12 11.7 0.2 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 KOG96328.1 - 0.056 12.8 0.2 0.49 9.7 0.0 2.3 3 0 0 3 3 3 0 KaiC AAA_25 PF13481.6 KOG96328.1 - 0.068 12.7 0.9 1.1 8.8 0.4 2.4 1 1 0 2 2 2 0 AAA domain TsaE PF02367.17 KOG96328.1 - 0.099 12.6 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 KOG96328.1 - 0.14 11.5 0.4 0.46 9.9 0.2 1.9 2 0 0 2 2 2 0 PhoH-like protein Cyclin_C_2 PF16899.5 KOG96329.1 - 8.9e-30 103.2 0.3 8.8e-29 100.0 0.0 2.3 2 0 0 2 2 2 1 Cyclin C-terminal domain Cyclin_N PF00134.23 KOG96329.1 - 5.5e-10 39.1 0.9 5.5e-10 39.1 0.9 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.19 KOG96329.1 - 0.0023 18.0 0.0 0.0045 17.0 0.0 1.5 1 0 0 1 1 1 1 Transcription factor TFIIB repeat OAD_gamma PF04277.13 KOG96329.1 - 1.4 9.5 4.0 7 7.3 0.2 2.7 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Glyco_hydro_65m PF03632.15 KOG96330.1 - 1.2e-31 109.9 4.5 2.1e-29 102.6 0.6 2.8 2 1 1 3 3 3 2 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.15 KOG96330.1 - 6.5e-28 97.9 0.0 1e-27 97.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65C PF03633.15 KOG96330.1 - 7.4e-05 22.6 0.2 0.00045 20.1 0.0 2.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 65, C-terminal domain Polysacc_synt_3 PF13440.6 KOG96330.1 - 0.014 14.7 0.1 0.026 13.8 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GATA PF00320.27 KOG96331.1 - 1.3e-13 50.3 4.5 2.6e-13 49.3 4.5 1.6 1 0 0 1 1 1 1 GATA zinc finger ArfGap PF01412.18 KOG96331.1 - 0.05 13.7 0.3 0.1 12.7 0.1 1.6 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf GLTP PF08718.11 KOG96332.1 - 0.095 13.0 0.3 19 5.5 0.0 2.3 2 0 0 2 2 2 0 Glycolipid transfer protein (GLTP) Adaptin_N PF01602.20 KOG96333.1 - 1.3e-132 443.0 20.0 1.9e-132 442.5 20.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 KOG96333.1 - 5.7e-12 45.9 0.0 1.4e-11 44.7 0.0 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Suf PF05843.14 KOG96333.1 - 0.062 13.3 0.6 0.11 12.4 0.6 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Arrestin_C PF02752.22 KOG96334.1 - 6.9e-10 39.5 4.0 1e-08 35.7 0.7 3.5 2 2 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 KOG96334.1 - 0.07 13.2 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain zf-HC5HC2H_2 PF13832.6 KOG96335.1 - 4.9e-30 103.9 11.1 4.9e-30 103.9 11.1 2.8 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 KOG96335.1 - 6.3e-26 90.5 9.1 6.3e-26 90.5 9.1 3.8 3 1 1 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.6 KOG96335.1 - 4.1e-13 48.6 2.0 4.1e-13 48.6 2.0 3.0 3 0 0 3 3 3 1 PHD-finger EPL1 PF10513.9 KOG96335.1 - 7e-12 46.0 2.2 1.6e-11 44.8 2.2 1.7 1 0 0 1 1 1 1 Enhancer of polycomb-like PHD PF00628.29 KOG96335.1 - 1.2e-10 41.1 3.7 1.2e-10 41.1 3.7 3.1 4 0 0 4 4 4 2 PHD-finger RcsC PF09456.10 KOG96335.1 - 0.019 14.9 0.0 8.7 6.4 0.0 2.7 2 0 0 2 2 2 0 RcsC Alpha-Beta-Loop (ABL) C1_1 PF00130.22 KOG96335.1 - 0.13 12.1 0.2 0.13 12.1 0.2 3.2 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 KOG96335.1 - 4.9 7.2 25.4 0.1 12.6 3.2 3.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Lgl_C PF08596.10 KOG96336.1 - 1.5e-149 498.0 0.3 5.6e-149 496.1 0.0 2.0 2 1 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 KOG96336.1 - 5.7e-08 32.9 0.2 0.57 10.5 0.0 4.7 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOG96336.1 - 0.03 13.7 0.1 0.072 12.4 0.1 1.6 1 0 0 1 1 1 0 WD40-like domain tRNA-synt_His PF13393.6 KOG96337.1 - 1.1e-37 129.9 0.0 8.3e-37 127.1 0.0 2.0 1 1 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 KOG96337.1 - 5.5e-13 48.9 0.0 1.1e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 KOG96337.1 - 0.0015 18.1 0.3 0.0039 16.7 0.0 1.7 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs tRNA-synt_2 PF00152.20 KOG96337.1 - 0.013 14.6 0.0 0.049 12.7 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class II (D, K and N) Actin PF00022.19 KOG96338.1 - 6e-52 176.6 0.1 1.3e-51 175.5 0.1 1.5 1 1 0 1 1 1 1 Actin ZnuA PF01297.17 KOG96338.1 - 0.059 12.8 0.1 0.076 12.4 0.1 1.3 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic GRIM-19 PF06212.12 KOG96338.1 - 0.067 13.1 0.1 0.22 11.5 0.1 1.8 1 0 0 1 1 1 0 GRIM-19 protein MreB_Mbl PF06723.13 KOG96338.1 - 0.11 11.3 0.1 5.3 5.8 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein Gln-synt_C PF00120.24 KOG96339.1 - 5.6e-19 68.3 0.0 6.5e-15 55.0 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 KOG96339.1 - 1.5e-13 50.3 0.0 3.9e-13 48.9 0.0 1.6 2 0 0 2 2 2 1 Glutamine synthetase, beta-Grasp domain V-ATPase_H_N PF03224.14 KOG96340.1 - 2.7e-70 237.2 12.3 2.7e-70 237.2 12.3 1.5 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 KOG96340.1 - 2.8e-40 137.1 3.8 7.6e-40 135.7 0.1 3.3 2 1 1 3 3 3 1 V-ATPase subunit H RPAP3_C PF13877.6 KOG96340.1 - 0.11 13.0 2.3 4.9 7.8 0.3 3.5 2 1 0 2 2 2 0 Potential Monad-binding region of RPAP3 Evr1_Alr PF04777.13 KOG96342.1 - 1e-22 80.5 1.2 1.3e-22 80.2 0.1 1.7 2 0 0 2 2 2 1 Erv1 / Alr family APOBEC1 PF18769.1 KOG96342.1 - 0.012 15.9 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 APOBEC1 Na_sulph_symp PF00939.19 KOG96342.1 - 0.035 13.1 0.0 0.049 12.7 0.0 1.1 1 0 0 1 1 1 0 Sodium:sulfate symporter transmembrane region TIP41 PF04176.13 KOG96343.1 - 1.1e-64 217.1 1.5 1.6e-64 216.5 1.5 1.3 1 0 0 1 1 1 1 TIP41-like family eIF-5_eIF-2B PF01873.17 KOG96344.1 - 4.5e-38 129.7 0.0 1e-37 128.6 0.0 1.6 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 KOG96344.1 - 3.6e-23 81.5 0.1 1.8e-21 76.1 0.0 2.7 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon PUF PF00806.19 KOG96345.1 - 3.4e-31 105.2 6.6 0.00013 21.4 0.0 6.6 6 0 0 6 6 6 6 Pumilio-family RNA binding repeat RRM_1 PF00076.22 KOG96345.1 - 2.1e-06 27.4 0.0 5.2e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L37ae PF01780.19 KOG96346.1 - 1.3e-40 137.3 9.2 1.5e-40 137.2 9.2 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 KOG96346.1 - 0.0043 17.2 2.6 0.0061 16.7 2.6 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Zn_Tnp_IS1595 PF12760.7 KOG96346.1 - 0.0067 16.4 2.2 0.012 15.6 2.2 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Rep_fac-A_C PF08646.10 KOG96346.1 - 0.0074 16.0 0.3 0.0083 15.9 0.3 1.2 1 0 0 1 1 1 1 Replication factor-A C terminal domain zf-H2C2_2 PF13465.6 KOG96346.1 - 0.032 14.7 1.4 1.1 9.8 0.2 2.3 2 0 0 2 2 2 0 Zinc-finger double domain DUF1364 PF07102.12 KOG96346.1 - 0.052 13.4 1.9 0.08 12.8 1.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1364) Sgf11 PF08209.11 KOG96346.1 - 0.053 13.1 0.4 0.62 9.7 0.0 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) CarbpepA_inh PF02977.15 KOG96346.1 - 0.064 13.1 3.9 0.13 12.1 0.8 2.1 1 1 1 2 2 2 0 Carboxypeptidase A inhibitor zf-ribbon_3 PF13248.6 KOG96346.1 - 0.068 12.6 1.8 4.1 6.9 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain C1_2 PF03107.16 KOG96346.1 - 0.082 13.2 2.6 0.43 10.9 2.7 1.8 1 1 1 2 2 2 0 C1 domain DUF2175 PF09943.9 KOG96346.1 - 0.097 13.0 0.4 4.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) zf-C4_ClpX PF06689.13 KOG96346.1 - 0.23 11.4 3.7 0.33 10.9 0.2 2.4 2 0 0 2 2 2 0 ClpX C4-type zinc finger SAC3_GANP PF03399.16 KOG96347.1 - 2.7e-17 63.1 9.4 3.2e-15 56.3 9.4 2.1 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 KOG96347.1 - 0.033 14.1 5.2 0.042 13.8 2.4 2.2 1 1 1 2 2 2 0 CSN8/PSMD8/EIF3K family PCI PF01399.27 KOG96347.1 - 0.27 11.7 2.3 1.1 9.9 0.5 2.4 2 0 0 2 2 2 0 PCI domain Herpes_U30 PF04523.13 KOG96348.1 - 1.4 6.7 8.5 0.57 8.0 3.1 2.0 1 1 1 2 2 2 0 Herpes virus tegument protein U30 tRNA-synt_2d PF01409.20 KOG96349.1 - 1.1e-47 162.6 0.2 1e-26 93.9 0.0 2.4 2 1 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 KOG96349.1 - 3.6e-28 97.8 0.0 2.9e-26 91.7 0.0 2.9 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain DUF3811 PF11656.8 KOG96349.1 - 0.044 14.2 0.0 0.14 12.6 0.0 1.8 1 0 0 1 1 1 0 YjbD family (DUF3811) Img2 PF05046.14 KOG96349.1 - 0.1 12.9 0.9 3.7 7.9 0.1 2.8 3 0 0 3 3 3 0 Mitochondrial large subunit ribosomal protein (Img2) FAD_binding_1 PF00667.20 KOG96350.1 - 2.6e-32 112.2 0.0 6.2e-32 111.0 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 KOG96350.1 - 1.6e-22 80.3 0.0 4.2e-22 78.9 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 KOG96350.1 - 3.2e-09 37.4 0.0 1.4e-08 35.3 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain ATG11 PF10377.9 KOG96351.1 - 3.6e-41 140.3 0.0 3.6e-41 140.3 0.0 2.9 3 0 0 3 3 3 1 Autophagy-related protein 11 YscO PF07321.12 KOG96351.1 - 0.088 12.8 10.6 0.037 14.0 4.4 2.7 2 0 0 2 2 2 0 Type III secretion protein YscO ABC_tran_Xtn PF12848.7 KOG96351.1 - 0.64 10.1 6.0 0.25 11.4 1.3 2.8 2 0 0 2 2 2 0 ABC transporter TPR_MLP1_2 PF07926.12 KOG96351.1 - 1.3 9.0 27.7 4.1 7.5 2.1 4.4 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 KOG96351.1 - 8.6 5.6 16.8 1.6 8.0 9.4 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) Acetyltransf_1 PF00583.25 KOG96352.1 - 4.1e-17 62.5 0.0 5e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOG96352.1 - 3.4e-10 39.9 0.0 4.7e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOG96352.1 - 5.3e-10 39.6 0.0 7.1e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOG96352.1 - 6.6e-07 29.2 0.1 1e-06 28.6 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 KOG96352.1 - 5.7e-05 23.8 0.0 6.6e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 KOG96352.1 - 0.00046 19.9 0.0 0.00069 19.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOG96352.1 - 0.00076 19.6 0.2 0.0027 17.8 0.1 1.9 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 KOG96352.1 - 0.0078 16.3 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.6 KOG96352.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase HMG_box PF00505.19 KOG96353.1 - 1.1e-26 93.0 2.5 1.1e-26 93.0 2.5 1.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOG96353.1 - 2.5e-19 69.6 2.3 3.5e-19 69.2 2.3 1.2 1 0 0 1 1 1 1 HMG-box domain Ccdc124 PF06244.12 KOG96353.1 - 0.0043 17.6 2.3 0.005 17.4 0.0 1.8 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 YABBY PF04690.13 KOG96353.1 - 0.16 12.5 2.5 0.12 13.0 1.1 1.4 1 1 1 2 2 2 0 YABBY protein Pkinase PF00069.25 KOG96354.1 - 1.1e-61 208.5 0.0 1.3e-61 208.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96354.1 - 1.3e-28 100.0 0.0 1.9e-28 99.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOG96354.1 - 0.0004 19.4 0.1 0.00079 18.5 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Sec8_exocyst PF04048.14 KOG96355.1 - 2e-52 176.9 3.4 2e-52 176.9 3.4 3.7 4 1 0 4 4 4 1 Sec8 exocyst complex component specific domain Sec5 PF15469.6 KOG96355.1 - 0.0012 18.7 11.5 0.0012 18.7 11.5 3.0 3 1 0 3 3 3 1 Exocyst complex component Sec5 T3SSipB PF16535.5 KOG96355.1 - 0.61 10.5 5.3 3.4 8.1 0.1 2.8 2 0 0 2 2 2 0 Type III cell invasion protein SipB COG2 PF06148.11 KOG96355.1 - 4.5 7.4 17.2 0.33 11.1 0.8 3.9 4 1 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Tfb4 PF03850.14 KOG96356.1 - 8.8e-107 356.7 0.3 1e-106 356.5 0.3 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Rad50_zn_hook PF04423.14 KOG96356.1 - 0.025 14.4 0.2 0.086 12.7 0.2 1.9 1 0 0 1 1 1 0 Rad50 zinc hook motif SIP1 PF04938.12 KOG96357.1 - 1.8e-10 40.9 1.1 3.7e-09 36.6 1.1 2.2 1 1 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) SLIDE PF09111.10 KOG96357.1 - 0.058 13.4 0.8 0.17 11.9 0.1 2.1 2 0 0 2 2 2 0 SLIDE DUF3014 PF11219.8 KOG96357.1 - 0.078 13.2 0.0 0.16 12.2 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3014) DUF3919 PF13057.6 KOG96357.1 - 0.11 12.1 5.8 0.07 12.7 3.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3919) Mito_carr PF00153.27 KOG96358.1 - 7.1e-62 205.4 1.1 6e-22 77.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein CM_2 PF01817.21 KOG96359.1 - 1.5e-06 28.5 0.1 0.036 14.4 0.2 2.8 2 1 0 2 2 2 2 Chorismate mutase type II DnaJ PF00226.31 KOG96360.1 - 7.9e-11 41.9 2.6 2.2e-09 37.3 2.6 2.4 1 1 0 1 1 1 1 DnaJ domain dCMP_cyt_deam_1 PF00383.23 KOG96361.1 - 7.8e-22 77.1 0.0 1.1e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KOG96361.1 - 4.8e-20 71.7 0.0 6.2e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 KOG96361.1 - 0.00032 20.8 0.0 0.0007 19.7 0.0 1.5 2 0 0 2 2 2 1 Secreted Novel AID/APOBEC-like Deaminase 4 Bd3614-deam PF14439.6 KOG96361.1 - 0.00058 19.9 0.4 0.003 17.6 0.3 1.9 1 1 1 2 2 2 1 Bd3614-like deaminase NAD1 PF18778.1 KOG96361.1 - 0.0014 18.8 0.1 0.021 14.9 0.0 2.0 2 0 0 2 2 2 1 Novel AID APOBEC clade 1 APOBEC2 PF18772.1 KOG96361.1 - 0.0026 17.9 0.0 0.047 13.8 0.0 2.0 2 0 0 2 2 2 1 APOBEC2 NAD2 PF18782.1 KOG96361.1 - 0.024 14.8 0.0 0.12 12.5 0.0 1.8 2 0 0 2 2 2 0 Novel AID APOBEC clade 2 APOBEC4_like PF18774.1 KOG96361.1 - 0.085 12.8 0.0 0.16 11.9 0.0 1.5 1 1 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase APOBEC_N PF08210.11 KOG96361.1 - 0.17 11.8 0.1 0.31 10.9 0.1 1.5 1 1 0 1 1 1 0 APOBEC-like N-terminal domain Inv-AAD PF18785.1 KOG96361.1 - 0.19 11.6 0.7 0.71 9.7 0.7 2.2 1 1 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase HMG_box PF00505.19 KOG96363.1 - 2.4e-17 63.1 1.2 6.4e-17 61.7 1.2 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOG96363.1 - 2.8e-06 27.8 0.1 2.8e-06 27.8 0.1 2.1 2 1 0 2 2 2 1 HMG-box domain RIB43A PF05914.12 KOG96363.1 - 0.18 10.5 21.0 0.26 10.0 21.0 1.1 1 0 0 1 1 1 0 RIB43A eIF-3_zeta PF05091.12 KOG96363.1 - 0.58 9.1 12.6 0.85 8.5 12.5 1.3 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4175 PF13779.6 KOG96363.1 - 2.4 5.9 18.2 3.2 5.5 18.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ThiF PF00899.21 KOG96364.1 - 1.9e-55 187.9 0.1 2.5e-55 187.5 0.1 1.1 1 0 0 1 1 1 1 ThiF family DUF5058 PF16481.5 KOG96364.1 - 0.0047 16.6 0.3 0.0075 16.0 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5058) Prolamin_like PF05617.11 KOG96364.1 - 0.014 15.6 1.0 7 6.9 0.0 2.6 1 1 1 2 2 2 0 Prolamin-like Sacchrp_dh_NADP PF03435.18 KOG96364.1 - 0.017 15.4 0.1 0.042 14.1 0.0 1.8 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Ldh_1_N PF00056.23 KOG96364.1 - 0.045 13.8 0.0 0.08 13.0 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Pyr_redox PF00070.27 KOG96364.1 - 0.085 13.4 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Spermine_synth PF01564.17 KOG96364.1 - 0.092 12.1 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Spermine/spermidine synthase domain Shikimate_DH PF01488.20 KOG96364.1 - 0.1 12.6 0.1 0.3 11.2 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DUF2062 PF09835.9 KOG96364.1 - 0.13 12.1 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) PglD_N PF17836.1 KOG96364.1 - 0.15 12.7 0.1 0.46 11.2 0.1 1.8 2 0 0 2 2 2 0 PglD N-terminal domain EZH2_N PF18601.1 KOG96364.1 - 0.18 12.1 0.4 5.9 7.3 0.1 2.5 1 1 1 2 2 2 0 EZH2 N-terminal domain Fe-S_biosyn PF01521.20 KOG96365.1 - 1.7e-13 50.7 0.0 4.7e-12 46.1 0.0 2.2 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis Hist_deacetyl PF00850.19 KOG96366.1 - 7.4e-74 249.0 0.0 9.5e-74 248.6 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Spermine_synth PF01564.17 KOG96367.1 - 3.5e-76 254.8 0.0 4.7e-76 254.4 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 KOG96367.1 - 1.7e-26 91.8 0.1 3e-26 91.1 0.1 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 KOG96367.1 - 0.00031 21.4 0.0 0.00064 20.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOG96367.1 - 0.0061 17.3 0.1 0.027 15.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 KOG96367.1 - 0.062 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Med1 PF10744.9 KOG96368.1 - 1.5e-23 83.6 17.8 6.2e-22 78.2 7.4 3.8 3 1 0 3 3 3 2 Mediator of RNA polymerase II transcription subunit 1 Not3 PF04065.15 KOG96369.1 - 5e-66 222.4 41.3 9.2e-66 221.6 31.5 3.2 2 2 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 KOG96369.1 - 1.3e-36 125.6 2.4 1.3e-36 125.6 2.4 2.8 4 0 0 4 4 4 1 NOT2 / NOT3 / NOT5 family YicC_N PF03755.13 KOG96369.1 - 0.038 14.5 4.3 0.11 13.0 4.3 1.8 1 0 0 1 1 1 0 YicC-like family, N-terminal region Erythro_esteras PF05139.14 KOG96369.1 - 0.56 10.0 3.7 0.61 9.8 0.3 2.1 1 1 1 2 2 2 0 Erythromycin esterase DUF5395 PF17373.2 KOG96369.1 - 3.2 8.5 6.4 0.86 10.3 0.3 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5395) Plasmid_RAQPRD PF09686.10 KOG96369.1 - 8.2 6.7 9.5 0.32 11.2 1.1 2.9 3 0 0 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) LMWPc PF01451.21 KOG96370.1 - 2.9e-51 173.6 0.0 3.3e-51 173.4 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Transketolase_N PF00456.21 KOG96371.1 - 3.5e-163 542.3 0.0 7e-163 541.3 0.0 1.5 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 KOG96371.1 - 5.9e-47 159.6 0.0 1.1e-46 158.7 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KOG96371.1 - 6.1e-17 61.7 0.0 1.4e-16 60.5 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 KOG96371.1 - 0.00012 21.4 0.0 0.00022 20.5 0.0 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 KOG96371.1 - 0.0017 18.2 0.5 0.034 13.9 0.5 2.5 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.20 KOG96371.1 - 0.0039 16.2 0.0 0.0083 15.1 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component XFP_C PF09363.10 KOG96371.1 - 0.2 11.1 0.0 0.34 10.3 0.0 1.3 1 0 0 1 1 1 0 XFP C-terminal domain Opy2 PF09463.10 KOG96372.1 - 2e-09 37.6 18.0 3e-09 37.0 18.0 1.3 1 0 0 1 1 1 1 Opy2 protein FAM176 PF14851.6 KOG96372.1 - 0.0021 17.7 0.0 0.0021 17.7 0.0 2.8 2 1 1 3 3 3 1 FAM176 family Amnionless PF14828.6 KOG96372.1 - 0.0081 15.0 0.0 0.012 14.5 0.0 1.2 1 0 0 1 1 1 1 Amnionless DUF2076 PF09849.9 KOG96372.1 - 0.056 13.5 0.6 0.056 13.5 0.6 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF4448 PF14610.6 KOG96372.1 - 0.11 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) SID-1_RNA_chan PF13965.6 KOG96372.1 - 0.13 10.6 0.0 0.2 10.0 0.0 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SKG6 PF08693.10 KOG96372.1 - 0.25 10.8 2.5 0.47 9.9 2.5 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain MAP17 PF15807.5 KOG96372.1 - 0.43 10.8 1.0 0.91 9.8 0.0 1.9 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 LRR19-TM PF15176.6 KOG96372.1 - 0.51 10.4 0.1 0.51 10.4 0.1 2.5 2 1 0 2 2 2 0 Leucine-rich repeat family 19 TM domain DUF2200 PF09966.9 KOG96373.1 - 0.03 14.5 0.1 0.062 13.4 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2200) Syntaxin_2 PF14523.6 KOG96373.1 - 1.2 9.6 12.6 17 5.8 0.2 2.7 2 1 0 2 2 2 0 Syntaxin-like protein CIMR PF00878.18 KOG96374.1 - 1.5e-08 34.9 1.5 7.4e-05 22.9 0.2 3.0 2 1 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.15 KOG96374.1 - 3.4e-06 26.4 0.0 5.1e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor PRKCSH_1 PF13015.6 KOG96374.1 - 2.1e-05 24.2 0.1 3.5e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein ATG27 PF09451.10 KOG96374.1 - 0.00015 21.7 0.7 0.00031 20.7 0.5 1.5 1 1 0 1 1 1 1 Autophagy-related protein 27 GTP_EFTU PF00009.27 KOG96375.1 - 4e-54 183.1 0.1 6.1e-54 182.5 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KOG96375.1 - 2.8e-40 137.1 0.0 6.6e-40 135.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KOG96375.1 - 3.1e-14 53.1 1.8 3.1e-14 53.1 1.8 2.6 4 0 0 4 4 4 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOG96375.1 - 0.00025 21.1 0.1 0.0064 16.6 0.2 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 KOG96375.1 - 0.14 12.1 4.7 0.062 13.2 0.9 2.2 2 0 0 2 2 2 0 Elongation factor Tu domain 4 HGTP_anticodon PF03129.20 KOG96376.1 - 9.2e-23 80.2 0.4 4.6e-22 78.0 0.3 2.2 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KOG96376.1 - 2.3e-08 34.2 0.0 1.3e-07 31.7 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) DIM1 PF02966.16 KOG96377.1 - 9.3e-68 226.1 0.6 1e-67 225.9 0.6 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Dynamin_N PF00350.23 KOG96379.1 - 0.0024 18.0 0.3 1.3 9.1 0.0 2.7 3 0 0 3 3 3 2 Dynamin family MMR_HSR1 PF01926.23 KOG96379.1 - 0.0034 17.5 0.0 0.29 11.2 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 KOG96379.1 - 0.0076 15.9 0.0 0.8 9.3 0.0 2.4 2 0 0 2 2 2 2 Ras family AAA_28 PF13521.6 KOG96379.1 - 0.026 14.7 0.0 0.063 13.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain Lyase_8_C PF02884.17 KOG96379.1 - 0.092 13.2 0.1 0.5 10.9 0.0 2.1 2 0 0 2 2 2 0 Polysaccharide lyase family 8, C-terminal beta-sandwich domain WD40 PF00400.32 KOG96380.1 - 0.0035 18.1 2.8 1.3 10.1 0.1 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat TFIIB PF00382.19 KOG96381.1 - 2.5e-44 149.2 2.6 3.5e-28 97.5 0.9 2.7 3 0 0 3 3 3 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 KOG96381.1 - 4.2e-13 48.6 0.7 7.5e-13 47.8 0.7 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding DUF1456 PF07308.13 KOG96381.1 - 0.015 15.6 1.3 0.063 13.6 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) zf-ribbon_3 PF13248.6 KOG96381.1 - 0.11 11.9 0.5 2.9 7.4 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 KOG96381.1 - 0.76 9.8 3.0 55 3.8 0.1 3.3 3 0 0 3 3 3 0 Putative transposase DNA-binding domain SRP54 PF00448.22 KOG96382.1 - 8.4e-79 263.8 4.2 1.2e-78 263.2 0.4 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 KOG96382.1 - 1.6e-28 99.3 11.8 1.6e-28 99.3 11.8 4.1 3 1 1 4 4 2 1 Signal peptide binding domain SRP54_N PF02881.19 KOG96382.1 - 9.8e-14 51.3 2.6 9.8e-14 51.3 2.6 2.1 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain CbiA PF01656.23 KOG96382.1 - 5.5e-05 23.2 0.0 0.00021 21.3 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain cobW PF02492.19 KOG96382.1 - 6.1e-05 22.7 2.4 0.0003 20.4 0.9 2.7 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 KOG96382.1 - 0.00019 20.8 0.1 0.0094 15.2 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_17 PF13207.6 KOG96382.1 - 0.00025 21.5 0.1 0.00025 21.5 0.1 2.8 3 1 0 3 3 3 1 AAA domain AAA_33 PF13671.6 KOG96382.1 - 0.00059 20.0 0.2 0.0019 18.3 0.0 2.0 3 0 0 3 3 1 1 AAA domain SRPRB PF09439.10 KOG96382.1 - 0.0016 17.9 8.0 1.9 7.9 0.1 4.3 4 1 0 4 4 4 2 Signal recognition particle receptor beta subunit MobB PF03205.14 KOG96382.1 - 0.0018 18.2 0.0 0.0068 16.3 0.0 2.0 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MipZ PF09140.11 KOG96382.1 - 0.0083 15.4 0.1 0.15 11.3 0.1 2.5 1 1 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.6 KOG96382.1 - 0.0086 16.0 2.9 0.033 14.1 0.2 2.7 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOG96382.1 - 0.011 16.2 0.0 0.028 14.8 0.0 1.7 2 0 0 2 2 1 0 AAA ATPase domain AAA_18 PF13238.6 KOG96382.1 - 0.012 16.1 0.0 0.048 14.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 KOG96382.1 - 0.015 14.3 3.1 0.03 13.3 0.1 2.9 3 1 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 KOG96382.1 - 0.025 14.4 0.4 0.091 12.5 0.2 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 KOG96382.1 - 0.026 14.8 0.2 0.67 10.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 KOG96382.1 - 0.03 14.2 0.0 0.078 12.9 0.0 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_22 PF13401.6 KOG96382.1 - 0.032 14.5 0.7 0.15 12.4 0.4 2.4 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KOG96382.1 - 0.049 13.3 0.2 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain CLP1_P PF16575.5 KOG96382.1 - 0.13 12.0 0.9 19 5.0 0.1 2.8 3 0 0 3 3 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_24 PF13479.6 KOG96382.1 - 0.14 11.9 2.6 0.21 11.3 0.1 2.4 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 KOG96382.1 - 0.59 10.2 3.5 0.65 10.1 0.3 2.7 3 1 0 3 3 2 0 50S ribosome-binding GTPase NTPase_1 PF03266.15 KOG96382.1 - 0.95 9.3 6.8 5.1 7.0 3.3 2.8 2 1 0 2 2 2 0 NTPase AAA PF00004.29 KOG96382.1 - 2.2 8.7 6.9 1.2 9.5 1.4 3.2 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) DIL PF01843.19 KOG96383.1 - 1.5e-15 57.4 1.9 3.5e-07 30.4 0.1 2.9 2 0 0 2 2 2 2 DIL domain Afi1 PF07792.12 KOG96383.1 - 8.3 6.9 14.5 2 8.9 6.2 2.8 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FAM60A PF15396.6 KOG96383.1 - 8.4 6.3 7.6 1.9 8.5 2.7 2.2 2 0 0 2 2 2 0 Protein Family FAM60A MMM1 PF10296.9 KOG96384.1 - 9.8e-10 38.0 2.6 9.8e-10 38.0 2.6 2.6 2 1 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 PH PF00169.29 KOG96384.1 - 4.4e-09 36.8 6.4 1.1e-07 32.3 0.4 3.2 2 1 1 3 3 3 2 PH domain PH_11 PF15413.6 KOG96384.1 - 1.5e-06 28.5 0.7 1.5e-06 28.5 0.7 3.4 2 1 1 3 3 3 1 Pleckstrin homology domain zf-RING_2 PF13639.6 KOG96385.1 - 2.3e-08 34.2 24.8 7.1e-08 32.7 8.6 2.4 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4 PF00097.25 KOG96385.1 - 4.1e-05 23.4 6.6 4.1e-05 23.4 6.6 2.7 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 KOG96385.1 - 0.00052 19.9 25.3 0.0085 16.0 10.9 2.8 2 1 0 2 2 2 2 PHD-finger zf-rbx1 PF12678.7 KOG96385.1 - 0.0008 19.6 11.6 0.0008 19.6 11.6 3.5 2 2 1 3 3 3 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KOG96385.1 - 0.0012 18.8 3.8 0.0012 18.8 3.8 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 KOG96385.1 - 0.0078 15.9 6.0 0.0078 15.9 6.0 3.1 3 0 0 3 3 3 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 KOG96385.1 - 0.013 15.1 20.4 0.28 10.9 5.8 2.7 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 KOG96385.1 - 0.013 15.3 5.6 0.013 15.3 5.6 3.0 2 1 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOG96385.1 - 0.014 15.4 6.6 0.014 15.4 6.6 2.6 2 0 0 2 2 2 0 zinc-RING finger domain DUF5318 PF17249.2 KOG96385.1 - 0.016 15.0 0.2 0.016 15.0 0.2 2.2 2 1 0 2 2 2 0 Family of unknown function (DUF5318) zf-HC5HC2H_2 PF13832.6 KOG96385.1 - 0.017 15.2 16.1 0.22 11.7 4.9 2.6 2 1 0 2 2 2 0 PHD-zinc-finger like domain zf-RING_UBOX PF13445.6 KOG96385.1 - 0.024 14.7 4.4 0.024 14.7 4.4 3.2 3 2 1 4 4 4 0 RING-type zinc-finger zf-HC5HC2H PF13771.6 KOG96385.1 - 0.19 12.0 16.7 0.7 10.2 4.5 3.1 2 1 1 3 3 3 0 PHD-like zinc-binding domain C1_2 PF03107.16 KOG96385.1 - 0.4 11.0 23.0 0.095 13.0 2.5 4.0 4 0 0 4 4 4 0 C1 domain Zf_RING PF16744.5 KOG96385.1 - 0.53 10.4 18.9 0.39 10.8 4.5 3.1 2 2 1 3 3 3 0 KIAA1045 RING finger Radial_spoke PF04712.12 KOG96385.1 - 0.67 8.8 4.3 0.56 9.1 2.1 1.7 2 0 0 2 2 2 0 Radial spokehead-like protein Baculo_IE-1 PF05290.11 KOG96385.1 - 0.81 9.6 9.0 3.4 7.6 1.9 2.4 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) Ribosomal_60s PF00428.19 KOG96385.1 - 1.9 9.1 7.3 3.1 8.5 7.3 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein FANCL_C PF11793.8 KOG96385.1 - 4 7.7 22.8 0.74 10.0 8.0 3.1 2 1 1 3 3 3 0 FANCL C-terminal domain PHF5 PF03660.14 KOG96386.1 - 1.4e-49 166.7 13.3 1.6e-49 166.5 13.3 1.0 1 0 0 1 1 1 1 PHF5-like protein Sec7 PF01369.20 KOG96387.1 - 9.5e-28 97.1 1.2 2.4e-27 95.8 1.2 1.7 1 0 0 1 1 1 1 Sec7 domain Dcc1 PF09724.9 KOG96387.1 - 0.6 9.4 6.1 0.25 10.6 0.0 2.2 2 0 0 2 2 2 0 Sister chromatid cohesion protein Dcc1 DUF3818 PF12825.7 KOG96388.1 - 3.9e-123 410.8 7.0 3.9e-123 410.8 7.0 2.8 3 0 0 3 3 3 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 KOG96388.1 - 2.2e-39 134.4 1.9 6.4e-39 132.9 1.9 1.8 1 0 0 1 1 1 1 PX-associated PX PF00787.24 KOG96388.1 - 2.3e-08 34.0 8.5 4.1e-08 33.2 5.5 2.8 2 1 0 2 2 2 1 PX domain DUF3298 PF11738.8 KOG96388.1 - 7.3 7.7 6.1 7.2 7.7 1.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3298) DUF4149 PF13664.6 KOG96389.1 - 1e-21 77.1 3.7 1.3e-21 76.8 2.4 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) L51_S25_CI-B8 PF05047.16 KOG96390.1 - 1.8e-14 53.3 0.0 3.1e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Ribosomal_L5_C PF00673.21 KOG96391.1 - 1.8e-22 79.3 0.0 3e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 KOG96391.1 - 2.4e-19 69.4 0.1 7.4e-19 67.8 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L5 Proteasome PF00227.26 KOG96392.1 - 6.5e-48 162.7 0.1 7.9e-48 162.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Forkhead PF00250.18 KOG96393.1 - 5e-25 87.6 0.1 1.7e-24 85.9 0.1 2.0 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 KOG96393.1 - 5.5e-12 45.9 0.3 1.1e-11 44.9 0.3 1.5 1 0 0 1 1 1 1 FHA domain Linker_histone PF00538.19 KOG96393.1 - 0.17 12.3 4.6 0.6 10.5 0.0 3.5 3 1 0 3 3 3 0 linker histone H1 and H5 family COG4 PF08318.12 KOG96394.1 - 4.4e-86 289.0 3.1 4.4e-86 289.0 3.1 2.6 3 0 0 3 3 3 1 COG4 transport protein Staphostatin_A PF09022.10 KOG96394.1 - 0.057 13.3 4.0 0.68 9.9 0.3 2.8 2 1 0 2 2 2 0 Staphostatin A Adhesin_P1_N PF18652.1 KOG96394.1 - 0.18 11.8 2.0 2.2 8.4 0.2 2.6 2 0 0 2 2 2 0 Adhesin P1 N-terminal domain MCPsignal PF00015.21 KOG96394.1 - 4.7 7.0 7.3 25 4.6 0.1 2.5 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Pkinase PF00069.25 KOG96395.1 - 3.6e-19 69.1 0.0 6.1e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96395.1 - 4.3e-09 36.0 0.0 8.7e-09 35.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG96395.1 - 1e-07 31.6 0.0 2e-07 30.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOG96395.1 - 0.00026 19.9 0.0 0.00039 19.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 KOG96395.1 - 0.081 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 KOG96395.1 - 0.12 11.7 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOG96395.1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-CCCH PF00642.24 KOG96396.1 - 1.3e-15 56.9 27.2 0.00038 20.3 0.4 5.4 4 2 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOG96396.1 - 8.8e-13 47.8 28.6 6.6e-06 26.0 2.5 5.3 5 0 0 5 5 5 4 Zinc finger domain Torus PF16131.5 KOG96396.1 - 1.7e-08 35.1 22.2 0.0023 18.6 0.3 4.9 1 1 4 5 5 5 3 Torus domain zf-CCCH_3 PF15663.5 KOG96396.1 - 3.8e-05 23.9 13.0 5.5e-05 23.4 5.4 2.4 1 1 1 2 2 2 1 Zinc-finger containing family zf-CCCH_4 PF18044.1 KOG96396.1 - 0.032 14.0 1.6 0.032 14.0 1.6 4.1 4 1 0 4 4 4 0 CCCH-type zinc finger RPN7 PF10602.9 KOG96397.1 - 1.7e-53 180.9 4.5 1.7e-53 180.9 4.5 1.7 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 KOG96397.1 - 5.3e-15 55.8 0.1 2.4e-14 53.7 0.0 2.1 2 0 0 2 2 2 1 PCI domain TPR_8 PF13181.6 KOG96397.1 - 6.3e-05 22.9 1.8 0.00018 21.5 0.3 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOG96397.1 - 0.0014 18.6 1.9 0.015 15.4 0.3 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOG96397.1 - 0.0021 18.3 0.6 0.027 14.7 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOG96397.1 - 0.014 15.2 2.3 0.014 15.2 0.5 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOG96397.1 - 0.022 14.8 0.0 1.5 9.0 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_15 PF13429.6 KOG96397.1 - 0.032 13.5 0.1 0.055 12.7 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOG96397.1 - 0.066 13.1 0.1 1.6 8.7 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5494 PF17598.2 KOG96397.1 - 0.088 12.9 2.1 0.79 9.9 0.1 3.3 3 2 2 5 5 5 0 Family of unknown function (DUF5494) Enolase_C PF00113.22 KOG96397.1 - 0.16 11.2 1.6 1.2 8.3 0.1 2.2 1 1 1 2 2 2 0 Enolase, C-terminal TIM barrel domain Csm1_N PF18504.1 KOG96397.1 - 0.29 11.5 3.1 21 5.6 0.6 3.0 2 0 0 2 2 2 0 Csm1 N-terminal domain DUF1746 PF08508.10 KOG96398.1 - 9.8e-06 25.9 2.0 0.00057 20.2 2.0 2.6 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1746) RNA_pol_A_bac PF01000.26 KOG96399.1 - 1.6e-29 102.5 0.0 3.5e-29 101.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 KOG96399.1 - 6.8e-20 70.3 0.0 9.2e-20 69.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Prot_ATP_OB_N PF17758.1 KOG96399.1 - 0.19 11.4 0.0 0.36 10.5 0.0 1.4 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain Pkinase PF00069.25 KOG96400.1 - 4.5e-55 186.8 0.7 1.6e-54 185.1 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96400.1 - 2.1e-27 96.1 0.6 4e-19 68.9 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 KOG96400.1 - 3.1e-05 24.6 2.3 7.4e-05 23.4 2.3 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 KOG96400.1 - 0.0023 16.9 1.0 0.012 14.6 0.8 2.0 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOG96400.1 - 0.0033 16.8 0.0 0.0077 15.6 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOG96400.1 - 0.032 13.6 0.0 0.16 11.3 0.0 2.0 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 KOG96400.1 - 0.086 12.8 0.1 0.43 10.5 0.0 2.0 1 1 0 2 2 2 0 Phosphotransferase enzyme family RRM_1 PF00076.22 KOG96401.1 - 4.6e-69 228.2 10.8 3.2e-17 62.1 0.1 6.4 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOG96401.1 - 7.6e-08 32.0 0.0 0.0016 18.0 0.1 4.0 3 1 1 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOG96401.1 - 6.6e-05 22.7 0.0 2.2 8.2 0.0 3.7 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 KOG96401.1 - 0.0001 22.3 0.6 4.3 7.5 0.0 4.5 5 0 0 5 5 5 2 RNA recognition motif Nup35_RRM_2 PF14605.6 KOG96401.1 - 0.0013 18.7 0.1 1.5 8.9 0.0 4.1 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 KOG96401.1 - 0.0032 17.5 1.7 1.7 8.8 0.0 4.3 4 1 0 4 4 4 1 Limkain b1 CDP-OH_P_transf PF01066.21 KOG96402.1 - 2.3e-13 50.7 0.5 2.3e-13 50.7 0.5 2.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase TRAM_LAG1_CLN8 PF03798.16 KOG96403.1 - 1.1e-32 113.3 18.9 1.1e-32 113.3 18.9 1.6 2 0 0 2 2 2 1 TLC domain PH PF00169.29 KOG96404.1 - 0.11 13.1 2.6 0.32 11.5 0.1 2.7 2 0 0 2 2 2 0 PH domain DUF3243 PF11588.8 KOG96404.1 - 0.12 12.7 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3243) RRG8 PF17068.5 KOG96405.1 - 4.8e-78 262.4 1.8 5.4e-78 262.2 1.8 1.0 1 0 0 1 1 1 1 Required for respiratory growth protein 8 mitochondrial Fmp27_WPPW PF10359.9 KOG96406.1 - 6.9e-135 450.6 0.1 1.3e-134 449.7 0.1 1.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Apt1 PF10351.9 KOG96406.1 - 1.1e-104 351.0 0.3 1.1e-104 351.0 0.3 2.8 3 0 0 3 3 3 1 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.9 KOG96406.1 - 4.6e-46 156.8 0.1 1.2e-45 155.4 0.1 1.8 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 KOG96406.1 - 2.9e-41 141.0 4.8 4.4e-41 140.4 3.2 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 KOG96406.1 - 1.1e-18 67.8 1.4 4.4e-18 65.9 0.1 2.9 3 0 0 3 3 3 1 RNA pol II promoter Fmp27 protein domain Get5_bdg PF16843.5 KOG96406.1 - 0.18 11.3 1.9 21 4.7 0.0 3.4 3 0 0 3 3 3 0 Binding domain to Get4 on Get5, Golgi to ER traffic protein IF-2B PF01008.17 KOG96407.1 - 5e-90 301.5 0.0 5.8e-90 301.3 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Cyclin_N PF00134.23 KOG96408.1 - 7.4e-40 135.6 0.2 2.2e-39 134.1 0.1 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOG96408.1 - 4.6e-32 110.6 0.0 1.2e-31 109.3 0.0 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 KOG96409.1 - 8.9e-41 138.6 0.5 1.8e-40 137.6 0.3 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOG96409.1 - 5.8e-19 68.3 0.3 2.5e-18 66.3 0.0 2.1 2 0 0 2 2 2 1 Cyclin, C-terminal domain Peptidase_M16 PF00675.20 KOG96410.1 - 4.3e-37 127.4 0.0 9.1e-37 126.3 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 KOG96410.1 - 6.3e-16 58.5 0.8 1.2e-15 57.5 0.8 1.5 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 KOG96410.1 - 5.2e-14 52.7 0.8 0.0081 16.2 0.0 5.2 4 2 0 4 4 4 3 Peptidase M16 inactive domain Ctr PF04145.15 KOG96411.1 - 3e-18 66.9 1.3 3e-18 66.9 1.3 2.5 3 0 0 3 3 3 1 Ctr copper transporter family DUF4229 PF14012.6 KOG96411.1 - 0.012 15.7 1.7 0.012 15.7 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) LETM1 PF07766.13 KOG96412.1 - 1.8e-87 293.1 3.3 1.8e-87 293.1 3.3 1.5 2 0 0 2 2 2 1 LETM1-like protein GPAT_N PF14829.6 KOG96412.1 - 0.021 14.8 0.1 0.1 12.6 0.1 2.2 2 0 0 2 2 2 0 Glycerol-3-phosphate acyltransferase N-terminal STAT_bind PF02864.15 KOG96412.1 - 0.51 10.9 3.8 0.18 12.4 0.7 1.8 2 0 0 2 2 2 0 STAT protein, DNA binding domain FRG PF08867.11 KOG96412.1 - 0.94 10.5 2.8 26 5.9 0.1 2.7 3 0 0 3 3 3 0 FRG domain Aldo_ket_red PF00248.21 KOG96413.1 - 5.7e-58 196.4 0.0 7e-58 196.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Mito_carr PF00153.27 KOG96414.1 - 3.9e-50 167.7 4.7 1.4e-19 69.8 0.5 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2700 PF10912.8 KOG96414.1 - 0.1 12.6 3.4 0.51 10.4 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2700) LSM14 PF12701.7 KOG96415.1 - 9.4e-25 86.5 0.0 1.6e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 KOG96415.1 - 5.1e-05 24.1 15.7 5.1e-05 24.1 15.7 3.9 3 2 0 3 3 3 1 FDF domain SM-ATX PF14438.6 KOG96415.1 - 0.011 15.8 0.0 0.024 14.8 0.0 1.6 1 0 0 1 1 1 0 Ataxin 2 SM domain Vac_ImportDeg PF09783.9 KOG96415.1 - 0.056 13.2 0.9 0.092 12.5 0.9 1.3 1 0 0 1 1 1 0 Vacuolar import and degradation protein Acetyltransf_1 PF00583.25 KOG96416.1 - 1.1e-08 35.3 0.0 1.4e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 KOG96416.1 - 1.4e-05 25.0 0.0 2.5e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 KOG96416.1 - 2.5e-05 24.6 0.0 4.6e-05 23.8 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOG96416.1 - 7.7e-05 22.6 0.0 0.00012 22.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Ribosom_S12_S23 PF00164.25 KOG96417.1 - 1.8e-51 172.5 0.3 2.3e-51 172.2 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Med26 PF08711.11 KOG96418.1 - 4.3e-12 45.9 0.0 1.6e-11 44.1 0.0 2.0 1 0 0 1 1 1 1 TFIIS helical bundle-like domain DUF4083 PF13314.6 KOG96418.1 - 0.13 12.2 1.5 0.41 10.6 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) MCM3AP_GANP PF16769.5 KOG96418.1 - 0.26 9.5 11.8 0.022 13.1 5.3 1.9 2 0 0 2 2 2 0 MCM3AP domain of GANP Tom5 PF10642.9 KOG96419.1 - 3.8e-19 68.4 0.4 4.2e-19 68.3 0.4 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase KORA PF16509.5 KOG96419.1 - 0.016 15.5 0.3 0.017 15.4 0.3 1.1 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor DUF3526 PF12040.8 KOG96419.1 - 0.041 14.4 0.1 0.044 14.3 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3526) Mcl1_mid PF12341.8 KOG96421.1 - 8.3e-84 281.4 0.0 9.1e-83 278.0 0.0 2.2 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 KOG96421.1 - 1.6e-05 25.1 0.2 0.71 10.2 0.0 4.2 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOG96421.1 - 0.0072 15.0 2.2 0.016 13.9 2.2 1.6 1 0 0 1 1 1 1 Nucleoporin Nup120/160 DNA_pol_alpha_N PF12254.8 KOG96421.1 - 0.053 13.6 1.2 0.24 11.5 1.2 2.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit p180 N terminal WD40 PF00400.32 KOG96422.1 - 4.5e-17 62.1 1.3 0.00012 22.7 0.0 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat WD40_like PF17005.5 KOG96422.1 - 0.019 14.3 0.0 0.65 9.3 0.0 2.9 3 0 0 3 3 3 0 WD40-like domain Ammonium_transp PF00909.21 KOG96423.1 - 1e-123 413.0 26.5 1.2e-123 412.8 26.5 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Phage_holin_2_1 PF04971.12 KOG96423.1 - 0.01 15.8 0.2 0.01 15.8 0.2 3.4 4 0 0 4 4 4 0 Bacteriophage P21 holin S Acyltransferase PF01553.21 KOG96425.1 - 2.3e-13 49.9 0.0 3.3e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Kinesin PF00225.23 KOG96426.1 - 5.3e-106 354.3 5.1 5.3e-106 354.3 5.1 2.0 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KOG96426.1 - 7.1e-56 188.3 0.2 7.1e-56 188.3 0.2 2.9 3 1 0 3 3 3 1 Microtubule binding HIP1_clath_bdg PF16515.5 KOG96426.1 - 0.014 16.0 11.5 0.014 16.0 11.5 5.0 2 1 3 6 6 6 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PolyA_pol PF01743.20 KOG96426.1 - 3.5 8.1 6.7 0.95 9.9 2.3 2.4 2 0 0 2 2 2 0 Poly A polymerase head domain Rrp15p PF07890.12 KOG96427.1 - 2.1e-29 102.5 13.4 2.1e-29 102.5 13.4 2.5 2 1 0 2 2 2 1 Rrp15p Glyco_hydro_63 PF03200.16 KOG96427.1 - 1.8 7.2 5.2 0.12 11.1 0.5 1.3 2 0 0 2 2 2 0 Glycosyl hydrolase family 63 C-terminal domain CDC45 PF02724.14 KOG96427.1 - 2.7 6.2 18.2 3.1 6.0 18.2 1.3 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 KOG96427.1 - 4 5.9 10.8 4.5 5.7 10.8 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Ndc1_Nup PF09531.10 KOG96427.1 - 8.6 4.9 8.1 9.7 4.7 8.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CBF PF03914.17 KOG96428.1 - 2.3e-33 115.6 1.0 6.2e-33 114.2 1.0 1.8 1 0 0 1 1 1 1 CBF/Mak21 family Asn_synthase PF00733.21 KOG96429.1 - 1.8e-93 314.1 0.4 6.2e-90 302.4 0.4 2.1 1 1 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 KOG96429.1 - 1.1e-33 115.7 0.0 1.8e-33 115.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 KOG96429.1 - 1e-26 93.7 0.0 2.7e-26 92.4 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 KOG96429.1 - 1.7e-05 24.4 0.0 3.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 KOG96429.1 - 0.056 12.6 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 NAD synthase RRS1 PF04939.12 KOG96430.1 - 0.011 15.6 1.0 0.012 15.4 1.0 1.0 1 0 0 1 1 1 0 Ribosome biogenesis regulatory protein (RRS1) LIDHydrolase PF10230.9 KOG96431.1 - 3e-74 249.9 4.0 3.5e-74 249.7 4.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_1 PF00561.20 KOG96431.1 - 4.3e-05 23.3 0.4 7.1e-05 22.6 0.2 1.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOG96431.1 - 9.7e-05 21.7 0.4 0.00019 20.8 0.1 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 KOG96431.1 - 0.0028 16.8 7.9 0.065 12.3 1.3 2.1 1 1 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_3 PF07859.13 KOG96431.1 - 0.0036 17.2 0.0 0.0066 16.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOG96431.1 - 0.0044 17.6 0.0 0.0047 17.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 KOG96431.1 - 0.0059 16.4 0.5 0.011 15.4 0.5 1.5 1 0 0 1 1 1 1 PGAP1-like protein Thioesterase PF00975.20 KOG96431.1 - 0.0076 16.4 0.0 0.012 15.8 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Peptidase_S9 PF00326.21 KOG96431.1 - 0.012 15.1 0.1 0.028 13.9 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family Ndr PF03096.14 KOG96431.1 - 0.022 13.5 0.1 0.035 12.8 0.1 1.4 1 0 0 1 1 1 0 Ndr family DLH PF01738.18 KOG96431.1 - 0.035 13.7 0.9 1.7 8.1 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Lipase_3 PF01764.25 KOG96431.1 - 0.039 13.8 0.6 0.07 13.0 0.1 1.7 2 0 0 2 2 2 0 Lipase (class 3) DUF1749 PF08538.10 KOG96431.1 - 0.11 11.5 1.6 0.12 11.5 0.3 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1749) BAR_2 PF10455.9 KOG96432.1 - 5.5e-105 350.6 43.7 1e-104 349.8 43.7 1.4 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking Utp14 PF04615.13 KOG96432.1 - 0.31 9.6 39.3 0.5 8.9 39.3 1.2 1 0 0 1 1 1 0 Utp14 protein BAR PF03114.18 KOG96432.1 - 2.1 8.0 32.8 16 5.0 21.9 4.2 2 1 1 3 3 3 0 BAR domain MARVEL PF01284.23 KOG96433.1 - 1.8e-27 96.1 12.8 2.2e-27 95.8 12.8 1.1 1 0 0 1 1 1 1 Membrane-associating domain Tetraspanin PF00335.20 KOG96433.1 - 0.57 9.9 10.0 0.43 10.2 7.9 1.7 1 1 1 2 2 2 0 Tetraspanin family Pet20 PF08692.10 KOG96434.1 - 3.7e-50 170.0 0.3 6.2e-50 169.2 0.3 1.3 1 0 0 1 1 1 1 Mitochondrial protein Pet20 Tmemb_170 PF10190.9 KOG96435.1 - 1.5e-15 57.5 11.9 1.8e-15 57.2 11.9 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 SH3_1 PF00018.28 KOG96436.1 - 2.2e-13 49.6 0.0 4.1e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOG96436.1 - 8.4e-12 44.8 0.0 1.2e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOG96436.1 - 7.8e-11 41.5 0.0 1.1e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Pex14_N PF04695.13 KOG96436.1 - 0.005 17.5 10.2 0.0069 17.1 10.2 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 KOG96436.1 - 0.019 15.0 8.3 0.021 14.9 8.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2076 PF09849.9 KOG96436.1 - 0.025 14.6 8.3 0.04 14.0 8.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Ndc1_Nup PF09531.10 KOG96436.1 - 1.7 7.2 5.1 2.1 6.9 5.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MSA-2c PF12238.8 KOG96436.1 - 8.5 6.3 17.1 2.4 8.1 13.7 1.7 2 0 0 2 2 2 0 Merozoite surface antigen 2c NCA2 PF08637.10 KOG96437.1 - 1.4e-101 339.5 1.9 1.4e-101 339.5 1.9 1.8 2 0 0 2 2 2 1 ATP synthase regulation protein NCA2 SpoV PF08183.11 KOG96437.1 - 0.17 11.9 0.2 5.6 7.0 0.1 2.5 2 0 0 2 2 2 0 Stage V sporulation protein family DUF4404 PF14357.6 KOG96437.1 - 0.52 11.0 9.1 6.7 7.4 3.1 4.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4404) MFS_1 PF07690.16 KOG96438.1 - 2e-32 112.5 32.7 2e-32 112.5 32.7 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG96438.1 - 2.1e-14 53.3 9.5 2.1e-14 53.3 9.5 1.5 2 0 0 2 2 2 1 Sugar (and other) transporter Vps62 PF06101.11 KOG96439.1 - 0.0013 17.1 6.4 0.013 13.9 3.8 2.4 2 1 0 2 2 2 2 Vacuolar protein sorting-associated protein 62 SKN1 PF03935.15 KOG96441.1 - 2.3e-252 837.8 4.8 2.8e-252 837.5 4.8 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Phosphorylase PF00343.20 KOG96442.1 - 0 1032.8 0.0 0 1032.6 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Pkinase PF00069.25 KOG96443.1 - 2.3e-78 263.2 0.0 3.1e-78 262.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96443.1 - 1.6e-31 109.5 0.0 2.6e-31 108.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOG96443.1 - 1.5e-07 30.7 0.3 2.9e-07 29.8 0.3 1.4 1 0 0 1 1 1 1 Haspin like kinase domain ORC4_C PF14629.6 KOG96444.1 - 2.6e-35 121.8 0.5 4.2e-35 121.1 0.5 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 KOG96444.1 - 8.2e-05 23.1 0.1 0.0002 21.8 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 KOG96444.1 - 0.073 13.1 0.4 0.51 10.4 0.4 2.6 1 1 0 1 1 1 0 AAA domain NERD PF08378.11 KOG96446.1 - 0.11 12.9 0.1 0.37 11.3 0.1 1.9 1 0 0 1 1 1 0 Nuclease-related domain Ras PF00071.22 KOG96447.1 - 2.2e-55 186.7 0.0 2.6e-55 186.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG96447.1 - 2.6e-21 76.0 0.0 5.1e-21 75.1 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG96447.1 - 7e-07 28.9 0.0 9.8e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOG96447.1 - 0.00071 19.2 0.0 0.002 17.7 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain LEA_5 PF00477.17 KOG96447.1 - 0.019 15.5 0.4 0.033 14.7 0.4 1.4 1 0 0 1 1 1 0 Small hydrophilic plant seed protein SRPRB PF09439.10 KOG96447.1 - 0.078 12.4 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KOG96447.1 - 0.11 11.9 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Ribosomal_S14 PF00253.21 KOG96448.1 - 2.4e-19 68.9 1.1 3.3e-19 68.4 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e PAPS_reduct PF01507.19 KOG96449.1 - 1.6e-44 152.0 0.0 2.2e-44 151.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family BCL9 PF11502.8 KOG96449.1 - 0.082 12.7 0.6 0.17 11.7 0.6 1.5 1 0 0 1 1 1 0 B-cell lymphoma 9 protein Med10 PF09748.9 KOG96450.1 - 8.1e-38 129.1 0.8 1.3e-37 128.5 0.1 1.6 2 0 0 2 2 2 1 Transcription factor subunit Med10 of Mediator complex Com_YlbF PF06133.11 KOG96450.1 - 0.097 13.3 2.6 1.5 9.4 0.0 2.3 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA DUF2203 PF09969.9 KOG96450.1 - 0.1 13.3 1.2 0.5 11.1 0.2 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) APOBEC3 PF18771.1 KOG96450.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 APOBEC3 ANAPC4_WD40 PF12894.7 KOG96451.1 - 3.7e-06 27.1 1.0 0.16 12.3 0.0 4.1 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nop14 PF04147.12 KOG96451.1 - 2.8 6.0 21.4 6.1 4.9 21.4 1.5 1 0 0 1 1 1 0 Nop14-like family HSP70 PF00012.20 KOG96451.1 - 5.6 5.0 11.7 8.7 4.4 11.7 1.2 1 0 0 1 1 1 0 Hsp70 protein CDC45 PF02724.14 KOG96451.1 - 6.2 5.0 17.5 13 3.9 17.5 1.4 1 0 0 1 1 1 0 CDC45-like protein Cytochrom_B562 PF07361.11 KOG96453.1 - 0.039 14.6 0.1 0.12 13.1 0.1 1.8 1 0 0 1 1 1 0 Cytochrome b562 Putative_PNPOx PF01243.20 KOG96454.1 - 1.9e-18 66.4 0.0 4.6e-18 65.2 0.0 1.6 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 KOG96454.1 - 0.017 14.7 0.0 0.27 10.8 0.0 2.2 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase like L_biotic_typeA PF04604.13 KOG96454.1 - 0.16 11.8 2.1 0.49 10.3 0.3 2.2 2 0 0 2 2 2 0 Type-A lantibiotic AAA PF00004.29 KOG96455.1 - 1.3e-43 148.5 0.0 2.4e-43 147.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 KOG96455.1 - 9.3e-30 102.4 0.5 2.8e-29 100.9 0.3 2.0 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 KOG96455.1 - 1.1e-23 83.0 5.1 3.5e-23 81.4 5.1 1.9 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 KOG96455.1 - 2.5e-06 27.2 0.0 1.8e-05 24.5 0.0 2.4 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 KOG96455.1 - 8.9e-06 26.2 0.1 0.0011 19.4 0.0 2.6 2 1 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 KOG96455.1 - 9e-06 25.5 0.0 1.5e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KOG96455.1 - 1.9e-05 24.7 0.0 7.3e-05 22.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 KOG96455.1 - 5.1e-05 23.1 0.0 0.0001 22.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 KOG96455.1 - 6.5e-05 23.2 0.4 0.013 15.8 0.0 2.6 2 1 1 3 3 2 1 AAA domain TIP49 PF06068.13 KOG96455.1 - 0.0001 21.6 0.0 0.00018 20.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 KOG96455.1 - 0.00012 22.1 0.0 0.00041 20.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 KOG96455.1 - 0.00023 20.4 0.0 0.00065 18.9 0.0 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 KOG96455.1 - 0.00028 21.2 0.2 0.0096 16.3 0.0 2.8 3 0 0 3 3 2 1 RNA helicase AAA_2 PF07724.14 KOG96455.1 - 0.00062 19.9 0.0 0.0019 18.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 KOG96455.1 - 0.00076 20.0 0.0 0.0024 18.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KOG96455.1 - 0.0022 17.7 0.0 0.0071 16.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOG96455.1 - 0.0024 18.0 0.0 0.0053 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 KOG96455.1 - 0.009 15.6 0.1 0.26 10.8 0.1 2.3 1 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 KOG96455.1 - 0.01 16.2 0.0 0.03 14.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOG96455.1 - 0.013 15.0 0.0 0.034 13.6 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region Torsin PF06309.11 KOG96455.1 - 0.018 15.2 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 Torsin Mg_chelatase PF01078.21 KOG96455.1 - 0.036 13.4 0.0 0.081 12.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 KOG96455.1 - 0.04 13.3 0.1 5.5 6.3 0.0 2.3 1 1 1 2 2 2 0 KaiC PhoH PF02562.16 KOG96455.1 - 0.075 12.5 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activat PF00158.26 KOG96455.1 - 0.087 12.5 0.0 0.29 10.8 0.0 1.8 1 1 1 2 2 2 0 Sigma-54 interaction domain ATPase_2 PF01637.18 KOG96455.1 - 0.089 12.7 0.5 2.1 8.2 0.0 2.5 2 1 1 3 3 2 0 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 KOG96455.1 - 0.093 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 KOG96455.1 - 0.11 12.3 0.0 0.75 9.7 0.0 2.0 1 1 1 2 2 2 0 NACHT domain CPT PF07931.12 KOG96455.1 - 0.12 12.2 0.0 0.43 10.4 0.0 1.8 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 KOG96455.1 - 0.15 11.3 0.1 1.2 8.4 0.1 2.2 1 1 1 2 2 2 0 Zeta toxin Use1 PF09753.9 KOG96455.1 - 0.3 10.8 1.3 0.6 9.8 0.9 1.6 2 0 0 2 2 2 0 Membrane fusion protein Use1 NBP1 PF08537.10 KOG96456.1 - 1.3e-36 126.7 3.6 1.3e-36 126.7 3.6 2.0 2 0 0 2 2 2 1 Fungal Nap binding protein NBP1 DNA_pol_E_B PF04042.16 KOG96457.1 - 4e-61 206.0 1.3 7e-61 205.2 1.3 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Prenyltrans PF00432.21 KOG96458.1 - 1.3e-64 213.6 3.1 7.1e-13 48.1 0.0 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 KOG96458.1 - 3.3e-05 23.2 0.0 0.0007 18.8 0.0 2.1 1 1 1 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 KOG96458.1 - 0.0051 16.0 0.0 4.9 6.2 0.0 3.4 1 1 3 4 4 4 2 Squalene-hopene cyclase N-terminal domain WD40 PF00400.32 KOG96459.1 - 4.2e-37 125.5 21.3 7.6e-08 32.9 0.9 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG96459.1 - 2.1e-11 44.0 2.6 0.013 15.8 0.2 5.1 2 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOG96459.1 - 0.00012 21.5 0.2 0.29 10.4 0.0 4.0 2 1 2 4 4 4 1 WD40-like domain eIF2A PF08662.11 KOG96459.1 - 0.00038 20.4 0.1 0.022 14.6 0.0 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Spt5_N PF11942.8 KOG96459.1 - 0.03 15.3 1.9 0.062 14.3 1.9 1.5 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal NUP50 PF08911.11 KOG96459.1 - 0.6 10.8 1.6 3 8.6 1.6 2.1 1 1 0 1 1 1 0 NUP50 (Nucleoporin 50 kDa) HDA2-3 PF11496.8 KOG96460.1 - 1.5e-94 316.5 0.8 3.2e-94 315.4 0.8 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Tox-REase-2 PF15646.6 KOG96460.1 - 0.54 10.4 3.0 7.2 6.8 0.9 3.2 2 1 1 3 3 3 0 Restriction endonuclease fold toxin 2 ThiF PF00899.21 KOG96461.1 - 6.3e-32 110.9 0.0 8.3e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 ThiF family Sec23_trunk PF04811.15 KOG96462.1 - 2.6e-74 249.9 0.0 3.6e-74 249.4 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 KOG96462.1 - 1.5e-29 102.6 0.0 3e-29 101.6 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 KOG96462.1 - 3.6e-27 94.2 0.1 9.5e-27 92.8 0.1 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 KOG96462.1 - 1.2e-12 47.6 7.6 2.2e-12 46.8 7.6 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KOG96462.1 - 2.9e-12 46.3 0.0 7.1e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 KOG96462.1 - 0.00093 18.5 0.9 0.002 17.5 0.9 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-MIZ PF02891.20 KOG96462.1 - 0.47 10.2 2.3 1 9.2 2.3 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger LSM PF01423.22 KOG96463.1 - 1.1e-19 69.9 0.2 1.2e-19 69.7 0.2 1.1 1 0 0 1 1 1 1 LSM domain Glycos_transf_2 PF00535.26 KOG96464.1 - 9.3e-30 103.7 0.0 1.7e-29 102.8 0.0 1.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KOG96464.1 - 1.5e-07 31.6 0.0 2.9e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 KOG96464.1 - 0.01 15.3 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 hDGE_amylase PF14701.6 KOG96465.1 - 1.1e-172 575.1 0.1 1.5e-172 574.6 0.1 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 KOG96465.1 - 1.7e-138 461.7 0.0 2.6e-138 461.1 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 KOG96465.1 - 4e-77 259.3 0.0 6.8e-77 258.6 0.0 1.4 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 KOG96465.1 - 5.6e-22 77.7 0.1 2.3e-21 75.7 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.24 KOG96465.1 - 0.00092 18.9 0.0 0.0049 16.5 0.1 2.0 2 0 0 2 2 2 1 Alpha amylase, catalytic domain ATG13 PF10033.9 KOG96466.1 - 2.4e-64 217.3 0.4 2.4e-64 217.3 0.4 2.0 2 0 0 2 2 2 1 Autophagy-related protein 13 KAsynt_C_assoc PF16197.5 KOG96466.1 - 0.018 15.5 1.9 0.044 14.2 1.9 1.6 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension RP-C_C PF11800.8 KOG96466.1 - 0.39 10.8 6.4 1 9.4 6.4 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region Membralin PF09746.9 KOG96466.1 - 0.62 9.0 5.0 1.3 8.0 5.0 1.4 1 0 0 1 1 1 0 Tumour-associated protein zf-C2H2 PF00096.26 KOG96467.1 - 2.9e-28 96.7 71.7 0.00011 22.4 2.8 9.3 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG96467.1 - 3.7e-23 80.2 68.2 7.4e-05 23.3 2.1 9.3 9 0 0 9 9 9 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOG96467.1 - 4.5e-11 42.6 64.1 0.00043 20.6 1.1 10.0 10 0 0 10 10 10 5 Zinc-finger double domain zf-met PF12874.7 KOG96467.1 - 2e-08 34.3 31.6 0.042 14.3 0.0 8.2 8 0 0 8 8 8 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KOG96467.1 - 2.2e-07 30.9 46.6 0.043 14.1 0.2 9.1 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding CpXC PF14353.6 KOG96467.1 - 0.00097 19.2 2.7 0.00097 19.2 2.7 4.2 2 2 2 4 4 4 1 CpXC protein zf-Di19 PF05605.12 KOG96467.1 - 0.0087 16.3 40.9 0.16 12.3 6.2 5.8 2 1 4 6 6 6 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 KOG96467.1 - 0.019 14.9 0.3 0.019 14.9 0.3 7.0 7 0 0 7 7 7 0 C2H2-type zinc finger TRAF6_Z2 PF18048.1 KOG96467.1 - 0.049 13.7 1.1 0.049 13.7 1.1 5.0 5 0 0 5 5 5 0 TNF receptor-associated factor 6 zinc finger 2 zf-ribbon_3 PF13248.6 KOG96467.1 - 0.84 9.1 13.1 3.7 7.1 0.0 4.4 4 0 0 4 4 4 0 zinc-ribbon domain zf-C2H2_11 PF16622.5 KOG96467.1 - 7.5 6.4 11.8 8.6 6.2 0.2 3.8 3 0 0 3 3 3 0 zinc-finger C2H2-type RNA_pol_Rpb6 PF01192.22 KOG96468.1 - 2.6e-17 62.5 0.1 3.8e-17 61.9 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 RRP7 PF12923.7 KOG96468.1 - 0.096 12.8 2.7 0.17 12.0 2.7 1.4 1 1 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain EF-hand_7 PF13499.6 KOG96469.1 - 5.9e-09 36.2 0.4 6.8e-06 26.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOG96469.1 - 6e-05 22.7 0.3 6e-05 22.7 0.3 2.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 KOG96469.1 - 0.00016 21.0 0.4 0.00016 21.0 0.4 2.8 4 0 0 4 4 4 1 EF hand EF-hand_1 PF00036.32 KOG96469.1 - 0.00021 20.6 0.3 0.00021 20.6 0.3 2.7 3 0 0 3 3 3 1 EF hand SPARC_Ca_bdg PF10591.9 KOG96469.1 - 0.019 15.3 0.7 0.033 14.5 0.3 1.7 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 KOG96469.1 - 0.026 14.3 0.1 0.086 12.7 0.1 2.0 1 0 0 1 1 1 0 EF-hand domain pair IF2_N PF04760.15 KOG96469.1 - 0.074 12.9 2.6 1.3 8.9 0.0 3.6 3 1 1 4 4 4 0 Translation initiation factor IF-2, N-terminal region DUF1456 PF07308.13 KOG96469.1 - 0.084 13.2 0.6 6.9 7.1 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1456) GED PF02212.18 KOG96469.1 - 0.15 12.2 0.1 0.41 10.8 0.1 1.8 2 0 0 2 2 2 0 Dynamin GTPase effector domain TPR_22 PF18833.1 KOG96470.1 - 2.2e-36 123.8 0.3 6.6e-36 122.3 0.3 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOG96470.1 - 2.9e-19 69.3 7.3 1.7e-05 25.2 0.0 8.6 9 2 2 11 11 9 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOG96470.1 - 7.5e-19 66.3 0.6 0.005 16.9 0.0 11.7 12 0 0 12 12 11 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOG96470.1 - 1.6e-17 62.9 0.0 0.00011 21.8 0.0 9.5 9 2 2 11 11 10 2 TPR repeat TPR_8 PF13181.6 KOG96470.1 - 7.8e-16 56.9 13.1 5.1e-05 23.2 0.0 11.4 12 0 0 12 12 11 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOG96470.1 - 8.1e-16 57.4 0.1 0.14 13.0 0.0 9.8 9 2 2 11 11 10 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOG96470.1 - 1.2e-15 56.6 10.3 0.00059 19.6 0.0 11.3 13 0 0 13 13 12 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOG96470.1 - 4.5e-15 56.0 0.0 0.004 17.8 0.0 7.5 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOG96470.1 - 1.4e-10 40.8 0.6 0.019 15.3 0.0 8.1 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOG96470.1 - 2.1e-10 40.8 0.5 0.032 14.5 0.2 7.2 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOG96470.1 - 3.2e-08 33.6 0.0 0.61 10.3 0.0 5.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOG96470.1 - 2.3e-06 27.9 0.9 9.1 7.2 0.0 7.1 6 0 0 6 6 6 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 KOG96470.1 - 3e-06 26.9 0.3 0.031 13.9 0.0 3.7 4 0 0 4 4 3 2 Bacterial type III secretion protein (HrpB1_HrpK) ANAPC3 PF12895.7 KOG96470.1 - 7.7e-06 26.1 10.8 0.007 16.6 0.1 6.4 8 0 0 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 Alkyl_sulf_dimr PF14863.6 KOG96470.1 - 0.00026 21.5 0.2 6 7.3 0.0 4.1 4 0 0 4 4 4 1 Alkyl sulfatase dimerisation TPR_10 PF13374.6 KOG96470.1 - 0.0014 18.4 0.1 29 4.7 0.0 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOG96470.1 - 0.0017 18.2 0.3 6.3 7.1 0.0 5.4 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 KOG96470.1 - 0.0044 17.3 0.1 2.7 8.4 0.0 4.4 4 2 1 5 5 3 1 Tetratricopeptide repeat TAtT PF16811.5 KOG96470.1 - 0.011 15.1 0.0 2.1 7.5 0.0 2.9 3 0 0 3 3 3 0 TRAP transporter T-component TPR_MalT PF17874.1 KOG96470.1 - 0.029 13.7 0.1 11 5.3 0.0 3.5 3 0 0 3 3 3 0 MalT-like TPR region CRISPR_Cas2 PF09827.9 KOG96470.1 - 0.048 13.9 0.1 1 9.6 0.0 3.2 1 1 1 2 2 2 0 CRISPR associated protein Cas2 PknG_TPR PF16918.5 KOG96470.1 - 0.09 11.5 0.1 1.4 7.6 0.0 2.7 3 0 0 3 3 3 0 Protein kinase G tetratricopeptide repeat RNA_pol_Rpc82 PF05645.13 KOG96471.1 - 4.3e-68 229.9 0.3 8.1e-68 229.0 0.3 1.5 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 KOG96471.1 - 1.2e-22 79.7 10.2 5.1e-19 68.1 0.2 3.7 4 0 0 4 4 4 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 KOG96471.1 - 0.00031 20.6 2.5 0.055 13.3 0.2 2.8 2 0 0 2 2 2 2 TFIIE alpha subunit DUF1707 PF08044.11 KOG96471.1 - 0.016 15.3 0.1 8.1 6.6 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1707) Peptidase_M16 PF00675.20 KOG96472.1 - 4.1e-32 111.2 0.0 6e-32 110.7 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KOG96472.1 - 0.054 13.5 0.2 0.87 9.6 0.1 2.6 2 1 0 2 2 2 0 Peptidase M16 inactive domain MIP PF00230.20 KOG96473.1 - 1e-43 149.7 15.2 1.3e-43 149.4 15.2 1.1 1 0 0 1 1 1 1 Major intrinsic protein MrpF_PhaF PF04066.13 KOG96473.1 - 0.026 14.9 1.0 0.12 12.8 1.0 2.2 1 0 0 1 1 1 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) Acetyltransf_1 PF00583.25 KOG96474.1 - 9e-16 58.2 0.0 1.1e-15 57.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOG96474.1 - 5.1e-08 33.2 0.1 1.3e-07 31.9 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOG96474.1 - 1e-07 32.0 0.0 1.2e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 KOG96474.1 - 2.1e-05 25.2 0.0 2.6e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KOG96474.1 - 3.2e-05 24.1 0.0 4.1e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOG96474.1 - 0.00019 21.3 0.0 0.00028 20.8 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Phage_30_8 PF06019.11 KOG96474.1 - 0.064 13.2 0.1 0.083 12.8 0.1 1.2 1 0 0 1 1 1 0 Phage GP30.8 protein Acetyltransf_CG PF14542.6 KOG96474.1 - 0.089 12.9 0.0 0.15 12.2 0.0 1.4 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase PanZ PF12568.8 KOG96474.1 - 0.1 12.4 0.0 0.23 11.2 0.0 1.6 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain, PanZ OPT PF03169.15 KOG96475.1 - 4.6e-170 567.3 49.1 5.3e-170 567.1 49.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF2198 PF09964.9 KOG96475.1 - 0.72 10.0 5.5 5.3 7.2 0.6 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2198) His_Phos_2 PF00328.22 KOG96476.1 - 1.3e-47 163.0 0.5 1.6e-47 162.7 0.5 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF4918 PF16265.5 KOG96476.1 - 0.043 13.3 0.0 0.086 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4918) PhyH PF05721.13 KOG96477.1 - 1.6e-34 120.0 0.3 2.1e-34 119.6 0.3 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 KOG96477.1 - 0.0037 17.7 0.5 0.0096 16.3 0.5 1.8 1 1 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase ADH_zinc_N PF00107.26 KOG96478.1 - 2.9e-13 49.9 0.1 4.5e-13 49.3 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOG96478.1 - 0.0053 16.6 0.1 0.068 13.1 0.1 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 KOG96478.1 - 0.12 13.4 0.0 0.19 12.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Semialdhyde_dh PF01118.24 KOG96478.1 - 0.12 12.8 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain HRXXH PF13933.6 KOG96479.1 - 4.8e-87 291.6 1.0 5.8e-87 291.3 1.0 1.0 1 0 0 1 1 1 1 Putative peptidase family Aspzincin_M35 PF14521.6 KOG96479.1 - 2.7e-08 34.5 0.5 4.7e-08 33.7 0.1 1.6 2 0 0 2 2 2 1 Lysine-specific metallo-endopeptidase DJ-1_PfpI PF01965.24 KOG96480.1 - 7.3e-09 35.6 0.0 1.9e-08 34.3 0.0 1.7 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 KOG96480.1 - 0.001 18.8 0.6 0.0035 17.0 0.6 1.9 1 1 0 1 1 1 1 ThiJ/PfpI family-like MFS_1 PF07690.16 KOG96481.1 - 2.7e-08 33.1 43.0 1.8e-07 30.5 41.1 3.0 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 KOG96481.1 - 3.5e-05 22.5 19.3 3.5e-05 22.5 19.3 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 KOG96481.1 - 8.1e-05 21.7 8.8 8.1e-05 21.7 8.8 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter WASH-7_C PF14746.6 KOG96481.1 - 0.11 12.2 0.0 0.32 10.7 0.0 1.7 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal SET PF00856.28 KOG96482.1 - 8.1e-05 23.1 0.0 0.00043 20.7 0.0 2.1 1 1 1 2 2 2 1 SET domain DUF507 PF04368.13 KOG96482.1 - 0.00029 20.8 0.9 0.0006 19.8 0.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF507) DUF3888 PF13027.6 KOG96482.1 - 0.055 13.9 0.5 0.45 11.0 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3888) MFMR PF07777.11 KOG96482.1 - 0.18 12.3 0.0 0.62 10.6 0.0 1.8 2 0 0 2 2 2 0 G-box binding protein MFMR CvfB_WH PF17783.1 KOG96483.1 - 0.013 15.3 0.1 0.041 13.7 0.1 1.8 1 0 0 1 1 1 0 CvfB-like winged helix domain AA_permease_2 PF13520.6 KOG96484.1 - 6.1e-62 209.8 44.9 8.9e-62 209.3 44.9 1.3 1 0 0 1 1 1 1 Amino acid permease Meckelin PF09773.9 KOG96484.1 - 0.086 10.9 0.5 0.17 10.0 0.5 1.4 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) ABC_tran PF00005.27 KOG96485.1 - 1.8e-56 190.5 0.2 1e-32 113.5 0.1 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 KOG96485.1 - 2.7e-52 178.1 39.4 3e-33 115.7 11.1 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_29 PF13555.6 KOG96485.1 - 4.2e-08 32.8 1.1 0.00049 19.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KOG96485.1 - 2.5e-05 24.3 0.1 0.0055 16.8 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.6 KOG96485.1 - 9.1e-05 22.4 4.5 0.59 9.9 0.1 3.9 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 KOG96485.1 - 0.00012 22.3 2.6 0.35 10.9 0.0 2.7 2 0 0 2 2 2 2 Helicase HerA, central domain RsgA_GTPase PF03193.16 KOG96485.1 - 0.00021 21.2 2.6 0.3 11.0 0.0 2.7 3 0 0 3 3 3 2 RsgA GTPase SMC_N PF02463.19 KOG96485.1 - 0.00048 19.6 8.5 0.01 15.3 0.7 3.9 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOG96485.1 - 0.00052 20.6 13.6 0.018 15.6 0.1 3.4 3 1 0 3 3 2 2 AAA domain FtsK_SpoIIIE PF01580.18 KOG96485.1 - 0.0011 18.4 0.2 0.66 9.3 0.1 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_16 PF13191.6 KOG96485.1 - 0.0019 18.6 0.2 0.38 11.1 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 KOG96485.1 - 0.0035 16.9 0.2 0.9 9.0 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Zeta_toxin PF06414.12 KOG96485.1 - 0.01 15.1 0.0 1.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 KOG96485.1 - 0.026 14.8 0.6 1.6 9.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 KOG96485.1 - 0.08 12.0 0.4 6.5 5.7 0.1 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_30 PF13604.6 KOG96485.1 - 0.11 12.3 0.1 1.5 8.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 KOG96485.1 - 0.25 11.4 2.9 16 5.5 0.6 3.0 3 0 0 3 3 3 0 Dynamin family RRM_1 PF00076.22 KOG96486.1 - 5e-20 71.1 5.2 2.6e-13 49.6 0.1 3.5 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOG96486.1 - 0.0058 16.7 0.1 1.2 9.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif RRM_Rrp7 PF17799.1 KOG96486.1 - 0.013 15.3 0.5 2.9 7.7 0.0 2.8 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain BRAP2 PF07576.12 KOG96486.1 - 0.11 12.8 0.4 0.59 10.4 0.1 2.2 2 1 0 2 2 2 0 BRCA1-associated protein 2 Ribosomal_L7Ae PF01248.26 KOG96487.1 - 1.4e-22 79.3 0.3 2.2e-22 78.6 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 KOG96487.1 - 0.00073 19.6 0.1 0.0013 18.8 0.1 1.4 1 0 0 1 1 1 1 RNase P subunit Pop3 V-SNARE_C PF12352.8 KOG96488.1 - 5.5e-20 71.4 3.5 5.5e-20 71.4 3.5 2.2 2 1 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus NADH_dehy_S2_C PF06444.11 KOG96488.1 - 0.052 14.1 0.4 0.13 12.8 0.4 1.7 1 0 0 1 1 1 0 NADH dehydrogenase subunit 2 C-terminus Syntaxin-6_N PF09177.11 KOG96488.1 - 0.19 12.3 10.2 0.13 12.9 1.4 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Muted PF14942.6 KOG96488.1 - 0.35 11.2 7.9 1.1 9.6 1.7 2.4 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein PMC2NT PF08066.12 KOG96488.1 - 0.37 11.5 7.5 10 6.9 0.1 3.1 1 1 2 3 3 3 0 PMC2NT (NUC016) domain BLOC1_2 PF10046.9 KOG96488.1 - 0.48 10.7 4.4 29 5.1 0.4 3.0 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF745 PF05335.13 KOG96488.1 - 0.58 9.8 4.2 1.3 8.7 0.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF745) Sec20 PF03908.13 KOG96488.1 - 1 9.3 8.8 0.13 12.2 0.6 2.8 2 1 1 3 3 3 0 Sec20 SYCE1 PF15233.6 KOG96488.1 - 1.3 9.1 7.6 14 5.7 3.1 2.6 1 1 0 2 2 2 0 Synaptonemal complex central element protein 1 Ecm29 PF13001.7 KOG96489.1 - 4.2e-141 471.0 9.0 4.2e-141 471.0 9.0 3.5 5 0 0 5 5 5 1 Proteasome stabiliser HEAT PF02985.22 KOG96489.1 - 4.7e-11 41.9 6.7 0.29 11.5 0.0 8.5 9 0 0 9 9 9 2 HEAT repeat Vac14_Fab1_bd PF12755.7 KOG96489.1 - 2.5e-06 28.0 1.2 0.042 14.4 0.0 6.7 5 2 2 7 7 7 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 KOG96489.1 - 0.00077 19.9 0.2 17 6.0 0.0 6.0 8 0 0 8 8 8 1 HEAT-like repeat LIN52 PF10044.9 KOG96489.1 - 0.11 13.3 0.9 0.61 10.8 0.1 2.7 2 0 0 2 2 2 0 Retinal tissue protein FliH PF02108.16 KOG96489.1 - 1.3 9.1 4.6 3.9 7.5 0.0 3.5 4 0 0 4 4 4 0 Flagellar assembly protein FliH RabGAP-TBC PF00566.18 KOG96490.1 - 8.7e-05 22.3 2.1 0.0038 16.9 0.1 2.8 3 0 0 3 3 3 2 Rab-GTPase-TBC domain RIFIN PF02009.16 KOG96491.1 - 0.0081 16.1 0.6 0.0081 16.1 0.6 2.6 1 1 1 2 2 2 1 Rifin PspB PF06667.12 KOG96491.1 - 0.016 15.2 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Phage shock protein B TMEM132D_C PF15706.5 KOG96491.1 - 0.1 12.4 0.2 0.41 10.5 0.0 2.1 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF5316 PF17247.2 KOG96491.1 - 0.13 12.3 0.0 0.42 10.6 0.0 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5316) Orf78 PF06024.12 KOG96491.1 - 0.52 10.6 3.4 1.5 9.2 0.0 3.0 2 1 0 2 2 2 0 Orf78 (ac78) Utp14 PF04615.13 KOG96491.1 - 8.2 4.9 14.1 12 4.3 14.1 1.2 1 0 0 1 1 1 0 Utp14 protein zf-C2H2 PF00096.26 KOG96492.1 - 3.6e-06 27.1 22.8 0.00041 20.6 1.8 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KOG96492.1 - 0.0012 19.1 1.3 0.012 15.9 0.1 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOG96492.1 - 0.0031 17.9 4.9 0.032 14.6 0.3 2.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KOG96492.1 - 0.0037 17.2 1.5 0.01 15.8 1.5 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOG96492.1 - 0.013 15.9 2.7 0.013 15.9 2.7 2.9 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOG96492.1 - 0.013 16.3 1.3 0.013 16.3 1.3 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger LAMTOR5 PF16672.5 KOG96492.1 - 0.12 12.3 0.1 0.49 10.4 0.1 2.1 2 0 0 2 2 2 0 Ragulator complex protein LAMTOR5 zf-C2H2_8 PF15909.5 KOG96492.1 - 0.38 11.1 8.0 0.16 12.2 4.8 2.1 2 0 0 2 2 2 0 C2H2-type zinc ribbon zf-C2HE PF16278.5 KOG96492.1 - 0.73 10.3 8.2 4.3 7.9 8.2 2.4 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger DUF2456 PF10445.9 KOG96493.1 - 6.9e-34 115.8 2.7 6.9e-34 115.8 2.7 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF2456) Coilin_N PF15862.5 KOG96494.1 - 0.025 14.4 2.0 0.064 13.1 2.0 1.6 1 0 0 1 1 1 0 Coilin N-terminus RP-C_C PF11800.8 KOG96494.1 - 0.14 12.2 6.7 0.33 11.0 6.7 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region CPSF100_C PF13299.6 KOG96494.1 - 0.31 11.2 3.8 0.57 10.4 3.8 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Velvet PF11754.8 KOG96494.1 - 0.41 10.6 7.7 0.21 11.5 6.0 1.4 1 1 0 1 1 1 0 Velvet factor Ndc1_Nup PF09531.10 KOG96494.1 - 0.49 9.0 5.0 0.93 8.1 5.0 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Roughex PF06020.11 KOG96494.1 - 0.79 8.8 15.7 0.32 10.1 12.8 1.6 2 0 0 2 2 2 0 Drosophila roughex protein DUF2722 PF10846.8 KOG96494.1 - 1.1 8.2 17.0 1.8 7.4 17.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 KOG96494.1 - 3.1 7.3 23.1 0.46 10.1 19.1 1.6 2 0 0 2 2 2 0 Spt20 family Presenilin PF01080.17 KOG96494.1 - 4.6 5.9 9.4 7.5 5.2 9.4 1.2 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 KOG96494.1 - 6.7 6.0 8.6 12 5.2 7.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) RRM_1 PF00076.22 KOG96495.1 - 2.2e-27 94.7 1.6 4.4e-14 52.0 0.1 4.0 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KOG96495.1 - 8e-05 22.6 0.1 0.025 14.6 0.1 2.5 2 0 0 2 2 2 2 RNA binding motif DUF386 PF04074.12 KOG96495.1 - 0.0079 16.1 1.2 0.018 14.9 1.2 1.6 1 0 0 1 1 1 1 YhcH/YjgK/YiaL RRM_5 PF13893.6 KOG96495.1 - 0.011 15.3 0.0 0.029 14.0 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KOG96495.1 - 0.037 14.0 0.3 4 7.5 0.0 3.0 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif NPR3 PF03666.13 KOG96496.1 - 1.6e-173 577.8 4.3 1.6e-173 577.8 4.3 2.9 3 0 0 3 3 3 1 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.11 KOG96496.1 - 0.00012 21.0 2.8 0.21 10.3 1.0 2.5 2 0 0 2 2 2 2 Nitrogen permease regulator 2 TP6A_N PF04406.14 KOG96497.1 - 9.2e-15 54.4 0.4 3.3e-14 52.6 0.1 2.1 2 0 0 2 2 2 1 Type IIB DNA topoisomerase TauD PF02668.16 KOG96498.1 - 4.2e-42 144.8 0.0 6.3e-42 144.2 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 KOG96498.1 - 0.042 14.5 0.0 0.5 11.0 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF971) DUF3048_C PF17479.2 KOG96498.1 - 0.12 12.7 0.8 6.2 7.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3048) C-terminal domain Vps51 PF08700.11 KOG96498.1 - 0.23 11.5 2.5 4.5 7.4 0.1 2.4 2 0 0 2 2 2 0 Vps51/Vps67 Opi1 PF08618.10 KOG96499.1 - 1e-30 107.4 4.2 1.5e-29 103.5 4.2 2.1 1 1 0 1 1 1 1 Transcription factor Opi1 GCIP PF13324.6 KOG96499.1 - 1.5 8.3 20.6 0.21 11.1 2.6 3.2 2 1 1 3 3 3 0 Grap2 and cyclin-D-interacting DUF3246 PF11596.8 KOG96499.1 - 2.6 7.4 8.0 10 5.5 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3246) Adap_comp_sub PF00928.21 KOG96500.1 - 1.8e-81 273.4 2.2 1.8e-81 273.4 2.2 2.0 2 0 0 2 2 2 1 Adaptor complexes medium subunit family SR-25 PF10500.9 KOG96500.1 - 0.045 13.3 18.6 0.091 12.4 18.6 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.11 KOG96500.1 - 0.047 13.9 13.2 0.027 14.7 10.8 1.9 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 CCDC106 PF15794.5 KOG96500.1 - 0.24 11.1 10.6 0.55 9.9 10.6 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Coilin_N PF15862.5 KOG96500.1 - 0.31 10.8 12.2 0.22 11.3 9.9 2.0 2 0 0 2 2 2 0 Coilin N-terminus CDC45 PF02724.14 KOG96500.1 - 2.5 6.3 7.2 4.3 5.5 7.2 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF3807 PF12720.7 KOG96500.1 - 3.7 7.8 11.2 7.6 6.8 11.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Pterin_4a PF01329.19 KOG96501.1 - 6.8e-21 74.2 0.2 7.9e-21 74.0 0.2 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Lung_7-TM_R PF06814.13 KOG96502.1 - 4.8e-88 295.2 29.4 5.8e-88 294.9 29.4 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor DUF202 PF02656.15 KOG96502.1 - 0.61 10.6 0.1 0.61 10.6 0.1 3.6 3 2 0 3 3 3 0 Domain of unknown function (DUF202) SSF PF00474.17 KOG96503.1 - 1.4e-16 60.4 27.5 2e-16 59.8 27.5 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family CoA_binding_3 PF13727.6 KOG96503.1 - 0.41 10.7 3.0 3.6 7.6 0.5 2.8 2 0 0 2 2 2 0 CoA-binding domain Ribosomal_S10 PF00338.22 KOG96504.1 - 8.4e-25 86.9 1.1 1e-24 86.6 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Phage_Gp19 PF09355.10 KOG96504.1 - 0.024 15.0 0.3 0.027 14.9 0.3 1.2 1 0 0 1 1 1 0 Phage protein Gp19/Gp15/Gp42 YchF-GTPase_C PF06071.13 KOG96505.1 - 5.6e-32 109.8 0.0 1.2e-31 108.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 KOG96505.1 - 8.3e-17 61.3 0.0 1.8e-16 60.2 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOG96505.1 - 0.00069 19.2 0.0 0.0015 18.1 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.21 KOG96505.1 - 0.00079 19.4 0.0 0.0016 18.4 0.0 1.5 1 0 0 1 1 1 1 TGS domain ABC_tran PF00005.27 KOG96505.1 - 0.61 10.6 2.1 12 6.4 0.1 2.5 2 1 0 2 2 2 0 ABC transporter OTU PF02338.19 KOG96506.1 - 1.3e-31 109.7 0.2 1.3e-31 109.7 0.2 1.8 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 KOG96506.1 - 8.8e-05 22.1 0.6 8.8e-05 22.1 0.6 2.5 2 1 0 2 2 2 1 Peptidase C65 Otubain ORF6C PF10552.9 KOG96506.1 - 0.55 10.3 9.3 0.095 12.8 1.1 2.7 2 0 0 2 2 2 0 ORF6C domain UDPGP PF01704.18 KOG96507.1 - 5.6e-116 387.6 0.3 6.7e-116 387.3 0.3 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Pribosyl_synth PF14572.6 KOG96508.1 - 8.7e-42 143.2 2.7 4.5e-36 124.6 2.1 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 KOG96508.1 - 3.9e-38 130.0 0.3 1.3e-37 128.2 0.0 2.0 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 KOG96508.1 - 1.6e-16 60.2 1.1 3.5e-16 59.1 0.6 1.7 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KOG96508.1 - 0.035 13.5 0.1 0.057 12.9 0.1 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase BRAP2 PF07576.12 KOG96509.1 - 3.8e-31 107.2 2.1 1.8e-30 105.0 0.3 2.3 2 0 0 2 2 2 1 BRCA1-associated protein 2 zf-UBP PF02148.19 KOG96509.1 - 3e-21 75.5 6.8 3e-21 75.5 6.8 1.7 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 KOG96509.1 - 4.1e-09 36.6 11.3 4.1e-09 36.6 11.3 2.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOG96509.1 - 1.5e-06 28.0 11.1 1.5e-06 28.0 11.1 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOG96509.1 - 2e-06 27.4 4.8 7.2e-06 25.6 4.8 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KOG96509.1 - 3.6e-06 26.9 4.5 3.6e-06 26.9 4.5 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 KOG96509.1 - 3.3e-05 24.1 8.1 3.3e-05 24.1 8.1 2.0 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KOG96509.1 - 6e-05 22.8 10.8 0.00017 21.4 10.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOG96509.1 - 6.1e-05 22.8 8.6 6.1e-05 22.8 8.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOG96509.1 - 8.1e-05 22.5 11.0 8.1e-05 22.5 11.0 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_4 PF14570.6 KOG96509.1 - 0.0011 18.7 8.0 0.0028 17.4 8.0 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 KOG96509.1 - 0.002 18.1 5.0 0.0078 16.2 5.0 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger JIP_LZII PF16471.5 KOG96509.1 - 0.0037 17.4 1.5 0.0037 17.4 1.5 2.4 2 0 0 2 2 2 1 JNK-interacting protein leucine zipper II zf-UBP_var PF17807.1 KOG96509.1 - 0.015 15.1 1.0 0.036 13.8 1.0 1.6 1 0 0 1 1 1 0 Variant UBP zinc finger Prok-RING_4 PF14447.6 KOG96509.1 - 0.083 12.8 23.1 0.023 14.5 13.6 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 NRBF2 PF08961.10 KOG96509.1 - 0.3 10.7 9.7 0.067 12.8 5.8 1.6 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Gmx_para_CXXCG PF09535.10 KOG96509.1 - 0.32 10.2 3.1 0.64 9.2 3.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (Gmx_para_CXXCG) AAA_11 PF13086.6 KOG96509.1 - 0.34 10.6 9.0 0.73 9.6 9.0 1.5 1 0 0 1 1 1 0 AAA domain FlaC_arch PF05377.11 KOG96509.1 - 0.53 10.7 5.3 0.73 10.3 0.2 2.9 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) EspB_PE PF18625.1 KOG96509.1 - 0.65 10.5 2.4 2.7 8.5 0.1 2.3 2 0 0 2 2 2 0 ESX-1 secreted protein B PE domain DUF4407 PF14362.6 KOG96509.1 - 4 6.7 9.4 6.6 6.0 9.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 KOG96509.1 - 7.1 6.1 10.1 11 5.5 10.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit bZIP_1 PF00170.21 KOG96510.1 - 1.3e-06 28.4 18.4 2.7e-06 27.4 18.4 1.5 1 0 0 1 1 1 1 bZIP transcription factor RIC3 PF15361.6 KOG96510.1 - 0.018 15.4 0.4 0.044 14.2 0.4 1.7 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 LCD1 PF09798.9 KOG96510.1 - 0.088 11.3 5.6 0.085 11.4 5.6 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein YabA PF06156.13 KOG96510.1 - 0.13 13.0 3.1 0.32 11.7 3.1 1.7 1 0 0 1 1 1 0 Initiation control protein YabA dsrm PF00035.26 KOG96510.1 - 0.14 12.9 2.3 0.56 10.9 0.5 2.7 3 0 0 3 3 3 0 Double-stranded RNA binding motif CASP_C PF08172.12 KOG96510.1 - 0.16 11.3 9.6 0.29 10.5 9.6 1.5 1 0 0 1 1 1 0 CASP C terminal bZIP_2 PF07716.15 KOG96510.1 - 0.17 12.0 16.3 0.48 10.6 16.3 1.8 1 0 0 1 1 1 0 Basic region leucine zipper DUF349 PF03993.12 KOG96510.1 - 0.37 11.1 9.7 0.74 10.1 9.7 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) V_ATPase_I PF01496.19 KOG96510.1 - 2.4 6.0 5.3 3.1 5.6 5.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 KOG96510.1 - 2.7 7.2 5.5 4.2 6.7 5.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Form_Nir_trans PF01226.17 KOG96511.1 - 5e-60 202.8 24.9 6.5e-60 202.4 24.9 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter RXLR PF16810.5 KOG96511.1 - 0.12 12.8 1.1 0.34 11.3 1.1 1.8 1 0 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity Pkinase PF00069.25 KOG96512.1 - 4.4e-74 249.2 0.0 7.1e-74 248.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96512.1 - 3e-47 161.1 0.0 5.2e-47 160.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 KOG96512.1 - 3.2e-23 81.8 0.0 1.3e-22 79.9 0.0 2.2 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 KOG96512.1 - 5e-05 22.2 0.0 5e-05 22.2 0.0 2.9 3 1 0 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 KOG96512.1 - 7.7e-05 22.2 0.0 0.00014 21.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like ANAPC15 PF15243.6 KOG96512.1 - 0.13 12.7 10.0 0.078 13.4 7.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 APH PF01636.23 KOG96512.1 - 0.18 11.7 0.0 2.1 8.2 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Ribosomal_S2 PF00318.20 KOG96514.1 - 2.6e-67 226.2 0.0 8e-67 224.6 0.0 1.8 1 1 0 1 1 1 1 Ribosomal protein S2 TRAM_LAG1_CLN8 PF03798.16 KOG96515.1 - 8.8e-39 133.3 25.8 8.8e-39 133.3 25.8 2.5 2 1 0 2 2 2 1 TLC domain TRAM1 PF08390.11 KOG96515.1 - 8.9e-21 73.3 2.3 8.9e-21 73.3 2.3 2.0 2 0 0 2 2 2 1 TRAM1-like protein VHS PF00790.19 KOG96516.1 - 6e-38 129.9 0.7 1.3e-37 128.7 0.7 1.6 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 KOG96516.1 - 1.3e-15 56.8 0.0 2.8e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOG96516.1 - 1.1e-12 47.7 0.0 2e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOG96516.1 - 1.3e-11 44.0 0.0 2.6e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 KOG96516.1 - 0.0003 21.0 2.4 0.0051 17.1 0.1 3.0 3 0 0 3 3 3 1 GAT domain UIM PF02809.20 KOG96516.1 - 0.013 15.4 0.9 0.037 13.9 0.9 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif ENTH PF01417.20 KOG96516.1 - 0.036 14.1 0.1 0.073 13.1 0.1 1.6 1 0 0 1 1 1 0 ENTH domain DUF3475 PF11961.8 KOG96516.1 - 0.13 12.4 0.1 0.35 11.0 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3475) DUF3959 PF13105.6 KOG96516.1 - 1.6 8.2 4.0 2.8 7.4 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) DUF4407 PF14362.6 KOG96516.1 - 3.8 6.8 5.5 2.3 7.5 2.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) MRP-S27 PF10037.9 KOG96516.1 - 4.9 5.9 12.8 9.4 5.0 12.6 1.6 1 1 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 Neur_chan_memb PF02932.16 KOG96516.1 - 5.1 7.1 6.5 1.2 9.1 3.1 1.7 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 KOG96516.1 - 5.7 5.7 8.3 4.1 6.1 5.7 1.8 2 0 0 2 2 2 0 Aluminium activated malate transporter Ribosomal_L14e PF01929.17 KOG96517.1 - 6.2e-33 113.1 0.8 1.2e-32 112.2 0.8 1.5 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 KOG96517.1 - 0.00063 19.6 0.4 0.0015 18.4 0.4 1.7 1 0 0 1 1 1 1 KOW motif Oxysterol_BP PF01237.18 KOG96518.1 - 5.7e-85 285.4 0.1 4.9e-83 279.0 0.1 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein QCR10 PF09796.9 KOG96519.1 - 6.4e-25 87.0 0.0 7.7e-25 86.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Ste5 PF11610.8 KOG96519.1 - 0.072 13.0 0.2 0.42 10.5 0.1 2.0 2 0 0 2 2 2 0 Scaffold protein Ste5, Fus3-binding region Mito_carr PF00153.27 KOG96520.1 - 2.8e-63 209.9 0.1 5.5e-22 77.5 0.0 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein ThiF PF00899.21 KOG96521.1 - 2.4e-43 148.3 0.0 3.6e-43 147.7 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 KOG96521.1 - 4.8e-05 23.4 0.0 8.4e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 KOG96521.1 - 0.0037 17.5 0.0 0.01 16.1 0.0 1.7 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.6 KOG96521.1 - 0.021 15.3 0.0 0.061 13.8 0.0 2.0 1 1 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox_2 PF07992.14 KOG96521.1 - 0.021 14.1 0.0 0.078 12.2 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 KOG96521.1 - 0.026 14.8 0.1 0.13 12.5 0.1 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 KOG96521.1 - 0.027 14.1 0.0 0.052 13.2 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 KOG96521.1 - 0.081 12.5 0.1 0.16 11.6 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NIF PF03031.18 KOG96522.1 - 1e-48 165.0 0.0 1.6e-48 164.4 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase G-alpha PF00503.20 KOG96523.1 - 2.4e-115 385.5 7.9 3.1e-115 385.1 7.9 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KOG96523.1 - 7.6e-16 58.1 0.8 1.3e-10 41.0 0.0 2.8 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOG96523.1 - 0.0016 17.9 0.4 0.13 11.6 0.1 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region TniB PF05621.11 KOG96523.1 - 0.093 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein zf-Tim10_DDP PF02953.15 KOG96524.1 - 1.4e-20 72.7 3.4 1.8e-20 72.3 3.4 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger zf-C2H2_4 PF13894.6 KOG96525.1 - 7.1e-05 23.3 11.1 0.077 13.9 1.5 4.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KOG96525.1 - 0.0031 17.9 13.8 0.011 16.2 3.7 3.8 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2HE PF16278.5 KOG96525.1 - 0.5 10.9 3.1 2 8.9 0.0 3.2 2 1 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger p450 PF00067.22 KOG96526.1 - 1.9e-113 379.6 0.0 2.2e-113 379.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DNA_pol_B_palm PF14792.6 KOG96526.1 - 0.057 13.6 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase beta palm Sod_Fe_C PF02777.18 KOG96527.1 - 1.5e-33 115.0 0.9 2.8e-33 114.1 0.2 1.8 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 KOG96527.1 - 6.1e-25 87.5 0.7 1.2e-24 86.5 0.7 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain HHH_2 PF12826.7 KOG96527.1 - 0.097 12.8 0.1 0.27 11.4 0.0 1.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif DAO PF01266.24 KOG96528.1 - 2e-90 303.9 0.0 4.5e-90 302.8 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOG96528.1 - 1.1e-06 28.8 0.1 2.7e-06 27.5 0.1 1.7 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 KOG96528.1 - 0.00078 18.4 0.1 0.022 13.6 0.2 2.2 2 0 0 2 2 2 1 Tryptophan halogenase Pyr_redox_2 PF07992.14 KOG96528.1 - 0.00086 18.6 0.0 0.002 17.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 KOG96528.1 - 0.0053 15.6 0.1 0.0078 15.0 0.1 1.2 1 0 0 1 1 1 1 MCRA family Thi4 PF01946.17 KOG96528.1 - 0.0056 16.0 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 KOG96528.1 - 0.0095 16.5 0.0 0.024 15.2 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOG96528.1 - 0.062 13.3 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Sacchrp_dh_NADP PF03435.18 KOG96528.1 - 0.1 12.8 0.1 0.25 11.6 0.1 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain tRNA-synt_2b PF00587.25 KOG96529.1 - 1e-23 84.2 0.0 1.9e-23 83.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 KOG96529.1 - 2.1e-05 24.7 4.7 2.1e-05 24.7 4.7 1.7 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain UPF0242 PF06785.11 KOG96529.1 - 0.00014 22.0 5.1 0.00025 21.2 5.1 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF641 PF04859.12 KOG96529.1 - 0.0051 17.1 2.6 0.012 16.0 2.2 1.8 1 1 0 1 1 1 1 Plant protein of unknown function (DUF641) DUF724 PF05266.14 KOG96529.1 - 0.0058 16.5 1.3 0.0058 16.5 1.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF724) Mod_r PF07200.13 KOG96529.1 - 0.13 12.4 3.4 0.54 10.4 3.4 1.9 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Lebercilin PF15619.6 KOG96529.1 - 0.14 11.8 4.5 0.27 10.9 4.5 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Fib_alpha PF08702.10 KOG96529.1 - 4.1 7.6 10.1 1 9.5 6.6 1.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Metallophos_2 PF12850.7 KOG96530.1 - 2.1e-09 37.8 0.0 3.1e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Acetyltransf_1 PF00583.25 KOG96531.1 - 2.4e-13 50.4 0.0 3.5e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOG96531.1 - 1.3e-07 31.6 0.0 2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOG96531.1 - 2.3e-05 24.3 0.0 4.3e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 KOG96531.1 - 0.00027 21.3 0.0 0.00046 20.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOG96531.1 - 0.015 15.4 0.0 0.027 14.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 KOG96531.1 - 0.03 13.8 1.2 0.045 13.2 0.9 1.6 1 1 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_3 PF13302.7 KOG96531.1 - 0.048 14.3 0.0 0.064 13.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Usp PF00582.26 KOG96533.1 - 0.019 15.5 0.0 0.034 14.6 0.0 1.4 1 0 0 1 1 1 0 Universal stress protein family Tn7_Tnp_TnsA_N PF08722.11 KOG96533.1 - 0.028 14.6 0.1 0.16 12.2 0.1 2.4 1 0 0 1 1 1 0 TnsA endonuclease N terminal Cpn10 PF00166.21 KOG96534.1 - 8.7e-27 93.0 0.3 1.1e-26 92.7 0.3 1.1 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit RisS_PPD PF16524.5 KOG96534.1 - 0.17 12.2 0.2 0.33 11.2 0.2 1.5 1 1 0 1 1 1 0 Periplasmic domain of Sensor histidine kinase RisS ATP19 PF11022.8 KOG96535.1 - 2e-18 66.5 0.0 2.7e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase subunit K RNA_Me_trans PF04252.13 KOG96536.1 - 1.6e-80 269.4 0.0 1.8e-80 269.2 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase DDHD PF02862.17 KOG96537.1 - 1.3e-37 130.1 7.5 1e-35 123.9 0.2 3.6 3 1 0 3 3 3 2 DDHD domain LCAT PF02450.15 KOG96537.1 - 0.00028 20.2 0.2 0.0046 16.2 0.0 2.2 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase WWE PF02825.20 KOG96537.1 - 0.081 13.5 0.1 0.37 11.4 0.0 2.2 2 0 0 2 2 2 0 WWE domain DUF2407_C PF13373.6 KOG96537.1 - 7.6 6.7 5.8 16 5.6 0.0 2.8 3 0 0 3 3 3 0 DUF2407 C-terminal domain DUF3439 PF11921.8 KOG96538.1 - 0.011 15.7 0.2 0.035 14.1 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Borrelia_orfA PF02414.15 KOG96538.1 - 1.5 8.4 9.2 5 6.7 1.6 2.2 2 0 0 2 2 2 0 Borrelia ORF-A SIR2 PF02146.17 KOG96539.1 - 2.4e-36 125.3 0.0 2.2e-35 122.2 0.0 2.1 1 1 0 1 1 1 1 Sir2 family WD40 PF00400.32 KOG96540.1 - 5.4e-06 27.0 0.6 0.021 15.7 0.0 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG96540.1 - 0.0017 18.6 0.0 0.12 12.7 0.0 3.1 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 KOG96540.1 - 0.0024 16.7 0.0 1.5 7.5 0.0 2.7 2 1 1 3 3 3 2 Nup133 N terminal like TPR_1 PF00515.28 KOG96541.1 - 4.4e-46 152.9 18.4 1.5e-07 30.9 0.1 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat STI1 PF17830.1 KOG96541.1 - 8.8e-36 121.6 15.4 2.3e-18 65.8 4.8 2.8 2 0 0 2 2 2 2 STI1 domain TPR_2 PF07719.17 KOG96541.1 - 4.5e-32 107.6 22.7 5.3e-06 26.1 0.1 9.6 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_11 PF13414.6 KOG96541.1 - 3.3e-21 74.7 23.3 0.00044 19.9 0.0 8.7 7 1 1 8 8 8 6 TPR repeat TPR_12 PF13424.6 KOG96541.1 - 4.7e-18 65.3 15.9 4.7e-05 23.6 0.8 6.5 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOG96541.1 - 1.4e-16 60.9 8.1 9.7e-05 22.9 0.0 5.9 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 KOG96541.1 - 1.6e-16 59.1 24.3 0.00012 22.0 0.1 9.0 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_17 PF13431.6 KOG96541.1 - 2.6e-14 52.5 8.0 0.016 15.5 0.0 7.8 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOG96541.1 - 2.4e-12 46.6 12.8 0.35 11.8 0.1 8.7 4 2 3 8 8 8 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOG96541.1 - 1e-11 44.0 13.0 0.0082 16.1 0.2 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOG96541.1 - 1.4e-11 44.7 20.6 0.00078 19.9 0.4 6.8 6 2 1 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOG96541.1 - 1.4e-06 28.3 4.1 0.00097 19.2 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOG96541.1 - 1e-05 25.2 14.1 0.16 11.9 0.3 7.4 6 1 1 7 7 7 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 KOG96541.1 - 0.00013 21.3 1.8 5.4 6.5 0.0 5.9 6 0 0 6 6 6 1 SHNi-TPR DUF3808 PF10300.9 KOG96541.1 - 0.0003 19.7 2.9 0.0039 16.0 0.0 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF3808) ANAPC3 PF12895.7 KOG96541.1 - 0.0057 16.9 9.5 1.3 9.3 0.3 4.1 3 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 KOG96541.1 - 0.014 15.7 12.8 0.56 10.6 0.5 5.5 4 3 1 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOG96541.1 - 0.071 13.8 21.1 21 6.0 0.2 8.2 8 0 0 8 8 8 0 Tetratricopeptide repeat XPC-binding PF09280.11 KOG96541.1 - 0.53 10.1 6.7 0.094 12.5 1.7 2.4 3 0 0 3 3 2 0 XPC-binding domain DUF5113 PF17140.4 KOG96541.1 - 2.5 7.9 6.9 1.4 8.7 0.1 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5113) TPR_4 PF07721.14 KOG96541.1 - 4.8 8.1 11.8 5.9 7.8 0.5 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat bZIP_1 PF00170.21 KOG96542.1 - 1e-12 48.0 8.2 1.8e-12 47.2 8.2 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 KOG96542.1 - 0.22 12.1 3.1 0.46 11.0 3.1 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor PalH PF08733.10 KOG96543.1 - 2.6e-96 322.5 18.1 3.4e-96 322.1 18.1 1.1 1 0 0 1 1 1 1 PalH/RIM21 Metallothi_Euk2 PF12809.7 KOG96544.1 - 6.3e-29 100.1 56.0 6.8e-29 100.0 56.0 1.0 1 0 0 1 1 1 1 Eukaryotic metallothionein HLH PF00010.26 KOG96545.1 - 3.1e-19 68.7 0.4 7.2e-19 67.5 0.4 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain XPG_N PF00752.17 KOG96546.1 - 5.1e-32 110.4 0.0 1.7e-31 108.7 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 KOG96546.1 - 1.7e-21 76.3 0.0 8.1e-21 74.2 0.0 2.3 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 KOG96546.1 - 0.00039 21.0 0.2 0.0069 17.0 0.0 2.8 2 1 1 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.7 KOG96546.1 - 0.0015 18.6 0.0 0.04 14.0 0.0 2.8 3 0 0 3 3 3 1 Helix-hairpin-helix motif XPG_I_2 PF12813.7 KOG96546.1 - 0.0072 15.8 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 XPG domain containing TPR_10 PF13374.6 KOG96546.1 - 0.1 12.5 0.1 3 7.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat SDA1 PF05285.12 KOG96546.1 - 7 6.0 12.5 12 5.1 12.5 1.4 1 0 0 1 1 1 0 SDA1 Ank_2 PF12796.7 KOG96547.1 - 1.4e-22 80.1 0.2 1.2e-11 45.0 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOG96547.1 - 1.8e-22 79.4 1.8 5.7e-08 33.2 0.1 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) DHHC PF01529.20 KOG96547.1 - 4.2e-22 78.7 5.9 4.2e-22 78.7 5.9 3.0 3 1 0 3 3 3 1 DHHC palmitoyltransferase Ank PF00023.30 KOG96547.1 - 1.4e-17 63.3 2.1 3.7e-06 27.1 0.2 4.9 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 KOG96547.1 - 1.5e-17 63.4 4.2 1.7e-06 28.2 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOG96547.1 - 7.7e-17 59.7 2.8 0.00024 21.3 0.0 5.9 6 0 0 6 6 6 3 Ankyrin repeat UNC45-central PF11701.8 KOG96548.1 - 2e-26 92.8 4.4 2e-26 92.8 4.4 3.6 3 1 0 3 3 3 1 Myosin-binding striated muscle assembly central Nop PF01798.18 KOG96548.1 - 0.026 14.0 1.4 0.067 12.7 1.4 1.6 1 0 0 1 1 1 0 snoRNA binding domain, fibrillarin DUF494 PF04361.13 KOG96548.1 - 0.029 14.3 0.3 0.095 12.6 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF494) Glyco_hydro_63 PF03200.16 KOG96548.1 - 0.052 12.3 0.1 0.11 11.3 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 C-terminal domain FAM150 PF15129.6 KOG96548.1 - 0.1 12.7 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 FAM150 family Tox-HDC PF15656.6 KOG96548.1 - 0.19 11.9 0.3 5.8 7.1 0.0 3.0 3 1 1 4 4 4 0 Toxin with a H, D/N and C signature Syntaxin_2 PF14523.6 KOG96549.1 - 3.5e-25 88.3 11.0 3.2e-22 78.8 4.5 2.4 2 0 0 2 2 2 2 Syntaxin-like protein SNARE PF05739.19 KOG96549.1 - 1.2e-15 57.3 0.2 3e-15 55.9 0.2 1.8 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 KOG96549.1 - 0.00072 19.3 18.5 0.0021 17.8 18.5 2.1 1 1 0 1 1 1 1 Syntaxin Synaptobrevin PF00957.21 KOG96549.1 - 0.016 15.0 2.1 0.016 15.0 2.1 2.8 4 0 0 4 4 4 0 Synaptobrevin BLOC1_2 PF10046.9 KOG96549.1 - 0.016 15.5 10.9 0.12 12.6 0.4 3.5 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Use1 PF09753.9 KOG96549.1 - 0.093 12.4 11.2 0.13 12.0 11.2 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 V-SNARE PF05008.15 KOG96549.1 - 0.16 12.4 5.5 0.54 10.7 0.5 3.2 2 2 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF16 PF01519.16 KOG96549.1 - 1.1 9.8 16.4 1.7 9.2 4.5 2.9 1 1 1 2 2 2 0 Protein of unknown function DUF16 FAM76 PF16046.5 KOG96549.1 - 1.3 8.3 11.7 1.9 7.7 10.6 1.7 1 1 1 2 2 2 0 FAM76 protein CEP209_CC5 PF16574.5 KOG96549.1 - 1.5 9.0 11.7 0.14 12.3 1.1 3.0 1 1 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 MSC PF09402.10 KOG96549.1 - 6.2 6.2 9.3 26 4.1 9.3 1.9 1 1 0 1 1 1 0 Man1-Src1p-C-terminal domain Fib_alpha PF08702.10 KOG96549.1 - 7.6 6.7 19.8 0.44 10.7 1.6 2.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FAD_binding_6 PF00970.24 KOG96550.1 - 1.6e-05 25.2 0.0 0.00018 21.8 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain Hira PF07569.11 KOG96551.1 - 6.5e-86 287.6 0.8 1.4e-84 283.3 0.2 2.6 2 0 0 2 2 2 1 TUP1-like enhancer of split WD40 PF00400.32 KOG96551.1 - 0.0002 22.1 2.3 1.6 9.7 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat CK_II_beta PF01214.18 KOG96552.1 - 1.9e-71 239.6 0.1 2.3e-71 239.4 0.1 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit HAGH_C PF16123.5 KOG96553.1 - 1.7e-18 66.9 0.1 3.2e-18 66.0 0.1 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 KOG96553.1 - 1.5e-09 38.2 0.1 4.4e-07 30.1 0.1 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KOG96553.1 - 0.0024 17.4 0.8 0.0044 16.6 0.8 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain CUE PF02845.16 KOG96554.1 - 8.2e-11 41.4 0.0 1.4e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 CUE domain FUSC-like PF12805.7 KOG96555.1 - 0.2 10.7 0.9 0.93 8.5 0.3 2.0 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS Tom6 PF17112.5 KOG96557.1 - 1.7e-27 94.7 1.7 2.1e-27 94.3 1.7 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom6, fungal DEAD PF00270.29 KOG96558.1 - 2.5e-36 125.1 1.0 3.6e-36 124.6 0.4 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG96558.1 - 1.6e-28 99.3 0.1 4.6e-28 97.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 KOG96558.1 - 0.0012 18.6 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOG96558.1 - 0.02 15.2 0.2 0.058 13.7 0.1 1.8 2 1 0 2 2 2 0 AAA domain STD1 PF17235.2 KOG96559.1 - 1.7e-73 246.7 0.4 2.8e-73 245.9 0.4 1.3 1 0 0 1 1 1 1 STD1/MTH1 XRN_M PF17846.1 KOG96560.1 - 3.3e-130 435.0 1.6 1.3e-96 324.2 0.2 3.4 3 1 1 4 4 4 2 Xrn1 helical domain XRN_N PF03159.18 KOG96560.1 - 1.9e-99 332.0 0.3 1.2e-98 329.4 0.0 2.5 3 0 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus RTA1 PF04479.13 KOG96561.1 - 2.3e-74 249.5 11.2 3.2e-74 249.0 11.2 1.2 1 0 0 1 1 1 1 RTA1 like protein Nro1 PF12753.7 KOG96562.1 - 5.1e-169 562.6 21.6 5.8e-169 562.4 21.6 1.0 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 FAST_1 PF06743.15 KOG96562.1 - 0.0037 17.2 0.0 0.014 15.3 0.0 1.9 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 1 SQS_PSY PF00494.19 KOG96562.1 - 0.014 14.9 0.6 0.038 13.5 0.0 2.0 3 0 0 3 3 3 0 Squalene/phytoene synthase TPR_19 PF14559.6 KOG96562.1 - 0.017 15.6 0.9 0.3 11.6 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOG96562.1 - 0.028 15.2 1.1 14 6.8 0.2 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat LMBR1 PF04791.16 KOG96562.1 - 4.3 6.1 8.4 6.8 5.5 3.3 2.4 1 1 1 2 2 2 0 LMBR1-like membrane protein zf-AN1 PF01428.16 KOG96563.1 - 1.8e-09 37.6 13.1 3e-09 36.9 13.1 1.4 1 0 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 KOG96563.1 - 0.04 14.3 8.5 0.065 13.6 8.5 1.3 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain C5HCH PF17982.1 KOG96563.1 - 0.92 9.7 10.0 1.6 8.9 10.0 1.4 1 0 0 1 1 1 0 NSD Cys-His rich domain Flavoprotein PF02441.19 KOG96564.1 - 2.1e-50 170.6 0.0 4.1e-50 169.6 0.0 1.5 1 1 0 1 1 1 1 Flavoprotein Presenilin PF01080.17 KOG96564.1 - 0.32 9.7 6.2 0.076 11.8 0.4 2.2 2 0 0 2 2 2 0 Presenilin TFIIA PF03153.13 KOG96564.1 - 9.2 6.1 37.3 0.17 11.8 21.1 2.8 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit PIN_6 PF17146.4 KOG96565.1 - 2.7e-31 107.9 0.1 6.5e-31 106.7 0.1 1.7 1 0 0 1 1 1 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 KOG96565.1 - 3.2e-24 84.9 0.9 7.1e-24 83.8 0.5 1.9 1 1 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN PF01850.21 KOG96565.1 - 0.14 12.7 0.0 0.32 11.5 0.0 1.6 1 0 0 1 1 1 0 PIN domain Presenilin PF01080.17 KOG96565.1 - 1.9 7.2 14.6 0.26 10.0 10.7 1.5 2 0 0 2 2 2 0 Presenilin SGS PF05002.15 KOG96566.1 - 1.6e-30 105.1 0.4 1.6e-30 105.1 0.4 2.2 3 0 0 3 3 3 1 SGS domain CS PF04969.16 KOG96566.1 - 5.2e-13 49.8 0.2 1.2e-12 48.7 0.2 1.6 1 0 0 1 1 1 1 CS domain ANAPC3 PF12895.7 KOG96566.1 - 0.026 14.8 1.9 5 7.4 0.3 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 KOG96566.1 - 2.6 8.4 4.9 10 6.5 0.3 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat MAP65_ASE1 PF03999.12 KOG96567.1 - 1.1e-164 549.5 38.5 1.7e-164 548.9 38.5 1.3 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) DLP_helical PF18709.1 KOG96567.1 - 0.00065 19.0 0.4 0.00065 19.0 0.4 3.0 3 1 0 3 3 3 1 Dynamin-like helical domain DUF676 PF05057.14 KOG96568.1 - 3.7e-60 203.1 0.0 5.2e-60 202.7 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 KOG96568.1 - 1.1e-06 28.5 0.0 1.7e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 KOG96568.1 - 2.5e-05 24.3 0.0 4.1e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Palmitoyl protein thioesterase FSH1 PF03959.13 KOG96568.1 - 0.0021 17.7 0.0 0.0036 17.0 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DUF2427 PF10348.9 KOG96568.1 - 0.052 13.3 0.3 0.097 12.5 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) Lipase_2 PF01674.18 KOG96568.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 2) Sld7_N PF18636.1 KOG96569.1 - 2.5e-40 137.7 0.0 4.3e-40 136.9 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial morphogenesis protein SLD7 N-terminal domain Sld7_C PF18596.1 KOG96569.1 - 6.3e-22 77.5 0.0 1.2e-21 76.6 0.0 1.5 1 0 0 1 1 1 1 Sld7 C-terminal domain FAM150 PF15129.6 KOG96569.1 - 0.022 14.9 0.9 0.11 12.6 0.2 2.2 1 1 1 2 2 2 0 FAM150 family Pkinase PF00069.25 KOG96570.1 - 3.9e-58 196.9 0.0 4.9e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96570.1 - 3.8e-16 59.2 0.0 5.4e-16 58.7 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOG96570.1 - 2.7e-07 30.7 0.0 1e-06 28.8 0.1 1.8 1 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 KOG96570.1 - 0.021 14.4 0.0 0.04 13.5 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 KOG96570.1 - 0.048 12.4 0.0 0.074 11.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 KOG96570.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L3 PF00297.22 KOG96573.1 - 3e-191 635.2 10.6 3.4e-191 635.0 10.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 PHD PF00628.29 KOG96574.1 - 0.00032 20.5 7.2 0.0006 19.6 7.2 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 KOG96574.1 - 0.016 15.4 1.7 0.03 14.6 1.2 1.7 1 1 0 1 1 1 0 PHD-like zinc-binding domain Cytochrom_C1 PF02167.15 KOG96575.1 - 6.9e-96 320.2 0.0 8.4e-96 319.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 KOG96575.1 - 0.0012 19.1 0.0 0.0024 18.2 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 KOG96575.1 - 0.0074 17.4 0.1 0.03 15.5 0.1 2.0 2 1 0 2 2 2 1 Cytochrome c Alg6_Alg8 PF03155.15 KOG96577.1 - 4.3e-165 550.3 38.4 5.2e-165 550.1 38.4 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Glyco_transf_56 PF07429.11 KOG96577.1 - 0.0088 15.2 0.7 0.19 10.8 0.1 2.1 2 0 0 2 2 2 2 4-alpha-L-fucosyltransferase glycosyl transferase group 56 Vps5 PF09325.10 KOG96578.1 - 4.5e-75 252.2 13.7 6.6e-75 251.7 13.7 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 KOG96578.1 - 2.7e-22 78.9 0.9 1e-21 77.0 0.2 2.3 2 0 0 2 2 2 1 PX domain DUF4363 PF14276.6 KOG96578.1 - 0.71 10.0 6.7 3 8.0 1.8 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4363) DUF4208 PF13907.6 KOG96578.1 - 0.72 10.3 5.3 14 6.2 1.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4208) RabGAP-TBC PF00566.18 KOG96579.1 - 6.9e-52 176.2 3.3 6.9e-52 176.2 3.3 2.0 3 0 0 3 3 3 1 Rab-GTPase-TBC domain Pneumovirus_M2 PF06436.11 KOG96579.1 - 0.07 12.6 0.4 0.21 11.1 0.4 1.9 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) Shugoshin_N PF07558.11 KOG96581.1 - 5.2e-16 58.2 5.6 1.7e-15 56.6 5.6 2.0 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 KOG96581.1 - 6.2e-09 35.5 4.4 2.5e-08 33.5 4.4 2.2 1 0 0 1 1 1 1 Shugoshin C terminus CHZ PF09649.10 KOG96581.1 - 0.041 13.4 0.7 0.1 12.1 0.7 1.7 1 0 0 1 1 1 0 Histone chaperone domain CHZ TSC22 PF01166.18 KOG96581.1 - 0.065 13.6 0.4 0.36 11.2 0.3 2.5 1 1 0 1 1 1 0 TSC-22/dip/bun family FHIPEP PF00771.20 KOG96581.1 - 2.5 6.5 5.5 0.3 9.5 0.9 1.6 2 0 0 2 2 2 0 FHIPEP family Syntaxin-18_N PF10496.9 KOG96582.1 - 3.2e-15 56.1 1.5 3.2e-15 56.1 1.5 2.3 2 1 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 KOG96582.1 - 5.7e-05 23.0 3.1 0.00055 19.9 0.1 3.2 3 0 0 3 3 3 1 SNARE domain Spore_III_AB PF09548.10 KOG96582.1 - 0.26 11.4 6.1 0.53 10.4 2.1 2.7 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) GTP_EFTU PF00009.27 KOG96583.1 - 1e-26 93.7 0.0 1.8e-26 92.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOG96583.1 - 1.3e-06 28.4 0.1 4e-06 26.9 0.1 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 KOG96583.1 - 0.056 13.2 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOG96583.1 - 0.067 13.1 1.0 1.6 8.6 0.1 2.8 2 1 0 2 2 2 0 RsgA GTPase Kin17_mid PF10357.9 KOG96584.1 - 4.3e-34 117.1 0.3 6.4e-34 116.6 0.3 1.3 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.8 KOG96584.1 - 1.4e-05 25.3 3.2 2.7e-05 24.3 3.2 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOG96584.1 - 0.00012 22.4 3.6 0.00029 21.1 3.6 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KOG96584.1 - 0.11 12.8 2.3 0.13 12.7 0.3 2.0 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 KOG96584.1 - 0.13 11.9 1.5 1.1 9.0 0.1 2.5 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain FANCF PF11107.8 KOG96584.1 - 1.2 8.3 4.5 4.1 6.5 4.5 2.0 1 1 0 1 1 1 0 Fanconi anemia group F protein (FANCF) U3_snoRNA_assoc PF08297.11 KOG96585.1 - 7.8e-21 74.6 6.8 7.8e-21 74.6 6.8 2.4 2 1 0 2 2 2 1 U3 snoRNA associated Zip PF02535.22 KOG96586.1 - 1.8e-52 178.6 13.5 1e-50 172.9 13.5 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter F-box PF00646.33 KOG96587.1 - 0.00035 20.4 0.4 0.0011 18.8 0.4 1.9 1 0 0 1 1 1 1 F-box domain TPR_2 PF07719.17 KOG96587.1 - 0.00094 19.1 0.0 4.8 7.6 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat F-box-like PF12937.7 KOG96587.1 - 0.002 18.0 0.4 0.0052 16.6 0.4 1.7 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 KOG96587.1 - 0.0062 16.9 19.8 0.13 12.7 1.3 6.7 3 1 3 6 6 6 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOG96587.1 - 0.0078 16.6 12.8 1.2 9.9 0.1 6.5 6 0 0 6 6 6 1 Leucine Rich Repeat LIAS_N PF16881.5 KOG96587.1 - 0.023 15.1 0.1 12 6.3 0.0 3.1 3 0 0 3 3 3 0 N-terminal domain of lipoyl synthase of Radical_SAM family TPR_1 PF00515.28 KOG96587.1 - 0.026 14.4 0.0 20 5.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat MAS20 PF02064.15 KOG96587.1 - 0.053 13.6 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 MAS20 protein import receptor ANAPC3 PF12895.7 KOG96587.1 - 0.055 13.7 1.4 0.65 10.3 0.6 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 LRR_8 PF13855.6 KOG96587.1 - 0.98 9.2 13.2 15 5.4 1.2 6.0 4 2 2 6 6 6 0 Leucine rich repeat LRR_6 PF13516.6 KOG96587.1 - 5 7.4 8.4 11 6.4 0.5 4.4 4 0 0 4 4 4 0 Leucine Rich repeat F-box-like_2 PF13013.6 KOG96587.1 - 6.8 6.7 7.6 7.4 6.6 3.4 3.0 1 1 1 2 2 2 0 F-box-like domain Abhydrolase_6 PF12697.7 KOG96588.1 - 3.9e-20 73.4 0.0 6e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOG96588.1 - 6.7e-05 22.3 0.0 0.00011 21.6 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 KOG96588.1 - 0.003 17.3 0.0 0.0042 16.8 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.20 KOG96588.1 - 0.006 16.2 0.7 0.043 13.5 0.7 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOG96588.1 - 0.088 12.3 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family OST3_OST6 PF04756.13 KOG96589.1 - 1.2e-77 261.2 6.8 1.4e-77 260.9 6.8 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family N_formyltrans_C PF18216.1 KOG96589.1 - 0.2 11.3 0.1 2.9 7.7 0.0 2.2 2 0 0 2 2 2 0 N-formyltransferase dimerization C-terminal domain TAP35_44 PF07265.11 KOG96589.1 - 2.8 8.0 6.9 0.59 10.2 0.1 2.7 3 0 0 3 3 3 0 Tapetum specific protein TAP35/TAP44 TcpE PF12648.7 KOG96589.1 - 7.4 7.2 15.7 0.23 12.0 3.5 2.9 2 1 0 2 2 2 0 TcpE family ThrE PF06738.12 KOG96589.1 - 9.2 5.5 11.4 1.8 7.9 1.0 2.3 2 0 0 2 2 2 0 Putative threonine/serine exporter C2 PF00168.30 KOG96590.1 - 1.3e-67 224.6 8.2 8.2e-22 77.5 0.1 4.5 4 0 0 4 4 4 4 C2 domain Ion_trans PF00520.31 KOG96591.1 - 0.0036 16.6 22.4 0.0036 16.6 22.4 2.4 2 1 0 2 2 2 1 Ion transport protein DUF4485 PF14846.6 KOG96591.1 - 0.0092 16.0 0.5 0.028 14.5 0.5 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4485) Carb_bind PF10645.9 KOG96591.1 - 0.033 14.4 0.1 0.067 13.4 0.1 1.4 1 0 0 1 1 1 0 Carbohydrate binding Ras PF00071.22 KOG96592.1 - 2e-60 203.1 0.0 2.4e-60 202.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG96592.1 - 6e-36 123.3 0.0 8.8e-36 122.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG96592.1 - 7.6e-18 64.6 0.1 9.1e-18 64.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOG96592.1 - 1.9e-08 34.0 0.0 2.4e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOG96592.1 - 1.3e-05 24.8 0.0 1.7e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOG96592.1 - 1.6e-05 25.0 0.0 2.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG96592.1 - 8.2e-05 22.6 0.0 0.066 13.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 KOG96592.1 - 0.045 14.1 0.0 0.067 13.6 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain PP2C PF00481.21 KOG96593.1 - 1.1e-54 185.9 0.0 2e-54 185.0 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C PMBR PF09373.10 KOG96593.1 - 0.05 13.8 0.0 25 5.3 0.0 3.0 3 0 0 3 3 3 0 Pseudomurein-binding repeat DFRP_C PF16543.5 KOG96594.1 - 6.8e-25 87.4 3.6 6.8e-25 87.4 3.6 3.4 3 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 Torus PF16131.5 KOG96594.1 - 6.2e-07 30.1 5.7 4.1e-05 24.2 0.7 2.9 1 1 1 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 KOG96594.1 - 8.9e-05 22.4 3.6 8.9e-05 22.4 3.6 3.1 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH PF00642.24 KOG96594.1 - 0.0029 17.5 0.4 0.0029 17.5 0.4 2.1 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KOG96594.1 - 0.023 14.5 8.0 0.027 14.3 1.1 3.1 3 0 0 3 3 3 0 CCCH-type zinc finger DUF3412 PF11892.8 KOG96594.1 - 0.046 13.8 0.1 0.41 10.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3412) zf-CCCH_3 PF15663.5 KOG96594.1 - 1.6 9.0 8.6 1.9 8.7 0.8 3.1 2 1 1 3 3 3 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 KOG96594.1 - 2.4 8.7 11.0 0.61 10.7 2.8 2.9 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger Mem_trans PF03547.18 KOG96595.1 - 1.6e-27 96.0 2.7 2.2e-27 95.5 2.7 1.3 1 0 0 1 1 1 1 Membrane transport protein AMP-binding PF00501.28 KOG96596.1 - 1.9e-37 128.9 0.0 1.2e-14 53.8 0.0 5.1 5 0 0 5 5 5 5 AMP-binding enzyme DMAP_binding PF06464.11 KOG96596.1 - 2.6e-22 79.7 3.8 7.5e-22 78.2 3.8 1.9 1 0 0 1 1 1 1 DMAP1-binding Domain MDFI PF15316.6 KOG96596.1 - 0.084 13.0 0.7 0.3 11.1 0.0 2.3 2 0 0 2 2 2 0 MyoD family inhibitor DUF3372 PF11852.8 KOG96596.1 - 0.1 12.1 0.7 0.56 9.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3372) Arf PF00025.21 KOG96597.1 - 7.9e-72 240.4 0.2 9.1e-72 240.2 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KOG96597.1 - 1.6e-15 57.4 0.2 2.7e-15 56.7 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KOG96597.1 - 2e-14 53.4 0.0 2.5e-14 53.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KOG96597.1 - 9.9e-14 51.3 2.6 3.2e-09 36.4 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 KOG96597.1 - 1.4e-12 47.5 0.0 1.8e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KOG96597.1 - 3.9e-10 39.5 0.0 4.9e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOG96597.1 - 0.00011 22.3 0.0 0.00014 21.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Rib_5-P_isom_A PF06026.14 KOG96598.1 - 6.9e-59 198.3 0.0 8.7e-59 198.0 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 KOG96598.1 - 0.0047 16.9 0.0 0.35 10.8 0.0 2.3 1 1 0 1 1 1 1 DeoR C terminal sensor domain Ribosomal_S7e PF01251.18 KOG96599.1 - 2.5e-79 265.4 2.6 2.9e-79 265.1 2.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Fig1 PF12351.8 KOG96600.1 - 0.1 12.5 0.1 0.15 12.0 0.1 1.2 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Glyco_transf_15 PF01793.16 KOG96602.1 - 2.9e-128 427.7 10.4 3.7e-128 427.4 10.4 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PsbJ PF01788.17 KOG96602.1 - 0.59 10.1 2.2 1.4 8.9 2.2 1.5 1 0 0 1 1 1 0 PsbJ Mito_carr PF00153.27 KOG96603.1 - 3.2e-57 190.5 5.4 1.4e-19 69.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ras PF00071.22 KOG96604.1 - 4.3e-56 189.0 0.1 5.6e-56 188.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG96604.1 - 2.2e-20 73.0 0.0 3.7e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG96604.1 - 5.5e-08 32.5 0.0 7.5e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KOG96604.1 - 0.00049 20.0 1.2 0.83 9.5 0.0 2.6 1 1 2 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 KOG96604.1 - 0.0014 18.2 0.3 0.0045 16.6 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOG96604.1 - 0.0017 18.4 0.0 0.003 17.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Menin PF05053.13 KOG96604.1 - 0.027 12.9 9.2 0.042 12.2 9.2 1.3 1 0 0 1 1 1 0 Menin FeoB_N PF02421.18 KOG96604.1 - 0.028 13.9 0.2 0.066 12.7 0.2 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 KOG96604.1 - 0.034 14.2 0.1 0.11 12.5 0.0 1.8 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain Utp14 PF04615.13 KOG96604.1 - 3.4 6.1 14.2 4.4 5.8 14.2 1.1 1 0 0 1 1 1 0 Utp14 protein SOG2 PF10428.9 KOG96604.1 - 9.3 5.3 13.3 13 4.9 13.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DAD PF02109.16 KOG96605.1 - 2.7e-38 130.6 6.9 3.1e-38 130.4 6.9 1.1 1 0 0 1 1 1 1 DAD family DUF2207 PF09972.9 KOG96605.1 - 0.073 11.8 1.9 0.079 11.7 1.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SNARE PF05739.19 KOG96607.1 - 6e-13 48.6 2.4 6e-13 48.6 2.4 1.8 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 KOG96607.1 - 0.0005 20.4 24.2 0.0025 18.2 2.6 4.1 3 1 0 3 3 3 2 Syntaxin-like protein Synaptobrevin PF00957.21 KOG96607.1 - 0.0016 18.2 1.6 0.0016 18.2 1.6 2.4 3 0 0 3 3 3 1 Synaptobrevin DHR10 PF18595.1 KOG96607.1 - 0.018 15.1 3.2 0.018 15.1 3.2 3.3 3 1 1 4 4 4 0 Designed helical repeat protein 10 domain Rx_N PF18052.1 KOG96607.1 - 0.022 15.0 0.1 0.022 15.0 0.1 2.5 3 0 0 3 3 3 0 Rx N-terminal domain Prominin PF05478.11 KOG96607.1 - 0.55 8.1 16.1 0.35 8.8 12.4 1.9 1 1 1 2 2 2 0 Prominin UPF0258 PF06789.12 KOG96607.1 - 2.3 8.3 6.4 1.5 8.9 0.5 2.7 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0258) Tweety PF04906.13 KOG96607.1 - 3.5 6.2 7.5 1.8 7.1 4.5 1.8 1 1 1 2 2 2 0 Tweety Phage_GPO PF05929.11 KOG96607.1 - 9.2 5.8 17.2 3.4 7.2 11.5 2.3 2 1 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase RGS PF00615.19 KOG96608.1 - 1.9e-10 41.0 2.3 1.9e-10 41.0 2.3 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain Antifungal_prot PF11402.8 KOG96608.1 - 0.014 15.6 0.5 1.1 9.6 0.1 2.5 2 0 0 2 2 2 0 Antifungal protein SPASM PF13186.6 KOG96608.1 - 0.026 15.0 0.6 0.19 12.3 0.1 2.3 2 0 0 2 2 2 0 Iron-sulfur cluster-binding domain HMGL-like PF00682.19 KOG96609.1 - 3.9e-91 305.3 0.0 5.5e-91 304.8 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 KOG96609.1 - 1.1e-27 96.5 0.6 2.2e-27 95.6 0.6 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain CGI-121 PF08617.10 KOG96609.1 - 0.13 12.4 0.3 0.44 10.6 0.0 2.0 3 0 0 3 3 3 0 Kinase binding protein CGI-121 Syja_N PF02383.18 KOG96610.1 - 6.3e-76 255.7 0.6 1.1e-75 254.9 0.6 1.4 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 KOG96610.1 - 1.3e-13 51.0 0.0 2e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Stealth_CR4 PF17103.5 KOG96610.1 - 0.16 11.9 0.2 0.45 10.4 0.2 1.8 1 0 0 1 1 1 0 Stealth protein CR4, conserved region 4 TFIIIC_sub6 PF10419.9 KOG96611.1 - 1.8e-22 79.0 0.8 4.8e-22 77.6 0.8 1.8 1 1 0 1 1 1 1 TFIIIC subunit triple barrel domain His_Phos_1 PF00300.22 KOG96611.1 - 1.6e-17 63.9 0.0 1.1e-16 61.1 0.0 2.4 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Maf PF02545.14 KOG96612.1 - 4.9e-38 130.6 0.0 6.1e-38 130.3 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein HisK_sensor PF18698.1 KOG96612.1 - 0.06 13.7 0.1 0.15 12.4 0.1 1.7 2 0 0 2 2 2 0 Histidine kinase sensor domain Cnd1 PF12717.7 KOG96613.1 - 0.0014 18.7 0.3 0.35 10.9 0.1 2.7 1 1 2 3 3 3 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KOG96613.1 - 0.0084 16.3 0.0 10 6.7 0.0 4.2 4 0 0 4 4 4 1 HEAT repeat CLASP_N PF12348.8 KOG96613.1 - 0.054 13.1 0.1 1.2 8.6 0.0 2.8 2 1 0 3 3 3 0 CLASP N terminal HEAT_EZ PF13513.6 KOG96613.1 - 0.094 13.3 0.1 65 4.2 0.0 4.1 3 1 1 4 4 4 0 HEAT-like repeat zf-H2C2_2 PF13465.6 KOG96614.1 - 1.1e-19 69.9 20.5 2.9e-08 33.8 0.8 4.5 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.26 KOG96614.1 - 2.6e-19 68.5 23.8 3.8e-05 23.9 0.2 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG96614.1 - 5.3e-12 45.5 21.2 0.0061 17.3 0.3 4.9 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOG96614.1 - 4.4e-05 23.6 11.2 0.11 12.8 0.1 4.8 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOG96614.1 - 6e-05 23.3 12.3 0.0019 18.5 0.3 4.9 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-Di19 PF05605.12 KOG96614.1 - 0.00018 21.7 6.6 0.0033 17.7 0.4 2.8 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 KOG96614.1 - 0.00019 21.4 22.8 0.0062 16.5 0.4 4.2 4 0 0 4 4 4 3 C2H2-type zinc finger PyrI_C PF02748.15 KOG96614.1 - 4 7.4 5.6 24 4.9 0.1 3.5 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.15 KOG96614.1 - 8.2 6.5 16.3 14 5.8 0.3 4.4 2 1 1 3 3 3 0 BED zinc finger zf-CHCC PF10276.9 KOG96614.1 - 8.6 6.5 12.3 8.7 6.5 0.2 3.2 3 0 0 3 3 3 0 Zinc-finger domain COX4 PF02936.14 KOG96615.1 - 0.046 13.7 1.6 1.5 8.9 0.1 2.7 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV KRAB PF01352.27 KOG96615.1 - 0.091 12.4 0.4 1.1 9.0 0.0 2.4 2 0 0 2 2 2 0 KRAB box TRAPP PF04051.16 KOG96616.1 - 8.5e-34 116.4 0.0 1.7e-33 115.4 0.0 1.5 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component RNA_pol_Rpb1_5 PF04998.17 KOG96617.1 - 1.8e-82 276.8 0.1 2.5e-82 276.3 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 KOG96617.1 - 3.4e-79 266.4 0.0 8e-79 265.2 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 KOG96617.1 - 4.5e-76 254.7 0.0 9.7e-76 253.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 KOG96617.1 - 3.3e-38 131.1 0.0 1e-37 129.5 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 KOG96617.1 - 2.1e-30 104.9 0.0 5e-30 103.6 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 AAA PF00004.29 KOG96618.1 - 5.5e-42 143.3 0.0 1.2e-41 142.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 KOG96618.1 - 2e-19 69.3 0.4 4e-19 68.3 0.4 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 KOG96618.1 - 6.7e-09 35.4 0.0 1.6e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KOG96618.1 - 1.4e-05 25.5 0.1 0.017 15.5 0.0 2.6 1 1 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 KOG96618.1 - 2.6e-05 24.2 1.0 8e-05 22.7 0.1 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KOG96618.1 - 2.7e-05 24.3 0.0 0.00016 21.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 KOG96618.1 - 0.00072 19.3 0.0 0.0019 18.0 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KOG96618.1 - 0.0011 19.1 0.4 0.02 15.1 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 KOG96618.1 - 0.0028 18.0 2.7 0.06 13.6 0.0 2.8 2 1 1 3 3 2 1 AAA domain PhoH PF02562.16 KOG96618.1 - 0.0054 16.2 0.2 0.061 12.8 0.1 2.2 2 0 0 2 2 2 1 PhoH-like protein DUF815 PF05673.13 KOG96618.1 - 0.0099 15.1 0.0 0.019 14.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 KOG96618.1 - 0.014 14.7 0.1 0.045 13.1 0.1 1.8 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 KOG96618.1 - 0.028 14.2 0.5 0.24 11.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 KOG96618.1 - 0.031 14.0 0.0 0.069 12.9 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 KOG96618.1 - 0.04 14.3 0.0 0.16 12.4 0.0 2.0 2 0 0 2 2 2 0 RNA helicase DUF1192 PF06698.11 KOG96618.1 - 0.07 13.2 0.9 0.2 11.7 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) AAA_19 PF13245.6 KOG96618.1 - 0.088 13.1 0.5 0.28 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KOG96618.1 - 0.093 12.2 0.0 0.22 11.0 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 KOG96618.1 - 0.13 12.0 0.6 0.29 10.8 0.1 2.0 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 KOG96618.1 - 0.17 11.2 1.7 0.32 10.3 0.0 2.2 3 0 0 3 3 3 0 KaiC ThylakoidFormat PF11264.8 KOG96618.1 - 0.21 11.3 2.7 0.44 10.2 2.7 1.5 1 0 0 1 1 1 0 Thylakoid formation protein Atg14 PF10186.9 KOG96618.1 - 0.22 10.6 1.9 0.35 9.9 1.9 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TolA_bind_tri PF16331.5 KOG96618.1 - 0.35 11.0 8.7 0.53 10.4 5.7 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation Fez1 PF06818.15 KOG96618.1 - 4.2 7.8 8.2 4.5 7.7 4.7 2.3 2 1 0 2 2 2 0 Fez1 TLD PF07534.16 KOG96619.1 - 3.5e-27 95.3 0.1 2.5e-26 92.5 0.1 2.3 2 0 0 2 2 2 1 TLD RIO1 PF01163.22 KOG96620.1 - 9.2e-73 243.9 0.9 9.2e-73 243.9 0.9 2.5 3 0 0 3 3 3 1 RIO1 family DUF4135 PF13575.6 KOG96620.1 - 0.026 13.9 0.0 0.054 12.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) APH PF01636.23 KOG96620.1 - 0.14 12.1 0.4 4.5 7.1 0.2 2.3 1 1 0 2 2 2 0 Phosphotransferase enzyme family Aldo_ket_red PF00248.21 KOG96621.1 - 1e-49 169.3 0.0 7e-48 163.3 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Profilin PF00235.19 KOG96622.1 - 4.1e-30 104.7 0.0 4.4e-30 104.5 0.0 1.0 1 0 0 1 1 1 1 Profilin NTNH_C PF08470.10 KOG96622.1 - 0.05 13.5 0.0 0.056 13.3 0.0 1.1 1 0 0 1 1 1 0 Nontoxic nonhaemagglutinin C-terminal Leo1 PF04004.13 KOG96623.1 - 4.2e-48 163.3 0.4 4.2e-48 163.3 0.4 3.0 3 1 0 3 3 3 1 Leo1-like protein UCH PF00443.29 KOG96624.1 - 3.7e-55 187.2 5.0 9.2e-55 185.9 5.0 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 KOG96624.1 - 4.6e-40 135.4 16.6 4.3e-16 58.6 1.0 4.9 4 0 0 4 4 4 4 A repeated domain in UCH-protein Col_cuticle_N PF01484.17 KOG96624.1 - 0.018 15.1 0.4 0.042 13.9 0.4 1.6 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain UCH_1 PF13423.6 KOG96624.1 - 0.079 12.5 16.3 1.5 8.3 16.3 2.5 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase COQ7 PF03232.13 KOG96625.1 - 2.7e-73 245.4 0.0 3.3e-73 245.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 KOG96625.1 - 0.13 12.7 0.0 0.93 9.9 0.0 2.2 2 1 1 3 3 3 0 Rubrerythrin Lipase_GDSL_2 PF13472.6 KOG96626.1 - 1.1e-21 78.0 0.0 1.9e-21 77.3 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 KOG96626.1 - 2.3e-16 60.4 0.0 3.1e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase RhoGAP PF00620.27 KOG96627.1 - 5.9e-46 156.1 0.6 2.4e-45 154.1 0.1 2.1 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 KOG96627.1 - 6.1e-10 39.2 31.3 2.7e-05 24.3 12.5 2.6 2 0 0 2 2 2 2 LIM domain APG6_N PF17675.1 KOG96627.1 - 0.00041 20.9 8.3 0.0024 18.4 8.3 2.3 1 0 0 1 1 1 1 Apg6 coiled-coil region Prenylcys_lyase PF07156.14 KOG96627.1 - 0.025 13.7 1.6 0.048 12.8 1.6 1.4 1 0 0 1 1 1 0 Prenylcysteine lyase KELK PF15796.5 KOG96627.1 - 0.26 11.8 6.2 0.8 10.2 6.2 1.8 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase TMF_TATA_bd PF12325.8 KOG96627.1 - 0.28 11.4 7.0 3.1 8.1 4.0 2.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Swi5 PF07061.11 KOG96627.1 - 5.2 7.2 7.1 7.3 6.8 3.3 2.8 2 0 0 2 2 2 0 Swi5 AIRC PF00731.20 KOG96628.1 - 1.7e-62 209.4 1.3 3.3e-62 208.5 1.3 1.5 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 KOG96628.1 - 3.3e-61 205.8 0.0 5.9e-61 205.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 KOG96628.1 - 6.9e-18 64.1 0.0 1.2e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain 2-Hacid_dh_C PF02826.19 KOG96628.1 - 0.00015 21.2 0.1 0.00064 19.1 0.0 2.0 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 KOG96628.1 - 0.00075 18.9 0.0 0.0016 17.7 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain CPSase_L_D2 PF02786.17 KOG96628.1 - 0.027 14.0 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 KOG96628.1 - 0.072 12.6 0.0 0.43 10.1 0.0 2.2 1 1 0 1 1 1 0 D-ala D-ala ligase C-terminus 3HCDH_N PF02737.18 KOG96628.1 - 0.1 12.4 0.0 0.3 11.0 0.0 1.8 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Afi1 PF07792.12 KOG96629.1 - 1.4e-29 103.3 1.2 3.3e-29 102.0 1.2 1.7 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 KOG96629.1 - 1e-26 93.1 0.1 2.2e-26 92.0 0.1 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Mito_carr PF00153.27 KOG96630.1 - 1e-58 195.3 2.2 3.1e-20 71.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HAD_2 PF13419.6 KOG96631.1 - 1.1e-17 64.7 0.2 1.7e-16 60.8 0.2 2.1 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOG96631.1 - 2.8e-15 57.2 0.0 1.8e-10 41.5 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOG96631.1 - 5.5e-09 36.0 0.0 1.7e-08 34.4 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.7 KOG96631.1 - 0.00096 19.6 0.0 0.0028 18.1 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 KOG96631.1 - 0.003 17.2 0.0 0.32 10.6 0.0 2.4 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase Hydrolase_3 PF08282.12 KOG96631.1 - 0.039 13.7 2.9 2 8.1 0.0 3.1 3 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase Glyco_hydro_127 PF07944.12 KOG96631.1 - 0.091 11.2 0.1 0.12 10.8 0.1 1.1 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 PX PF00787.24 KOG96632.1 - 4.4e-12 46.0 0.4 1.2e-11 44.6 0.4 1.8 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 KOG96632.1 - 0.0043 16.6 10.0 0.0088 15.6 10.0 1.5 1 0 0 1 1 1 1 Vps5 C terminal like NAD_binding_5 PF07994.12 KOG96632.1 - 0.053 12.9 0.8 0.11 11.9 0.5 1.7 1 1 0 1 1 1 0 Myo-inositol-1-phosphate synthase GTP_EFTU PF00009.27 KOG96633.1 - 1.6e-67 226.8 0.3 2.3e-67 226.3 0.3 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 KOG96633.1 - 9e-33 112.6 0.1 7.2e-32 109.7 0.0 2.3 1 1 1 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 KOG96633.1 - 6.7e-22 77.3 0.0 1.9e-21 75.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 KOG96633.1 - 1.7e-13 50.4 0.0 6.6e-13 48.6 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 KOG96633.1 - 2.9e-13 50.0 0.3 1e-12 48.3 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOG96633.1 - 0.00018 21.6 0.3 0.00036 20.6 0.3 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RhoGAP PF00620.27 KOG96634.1 - 2.2e-35 121.7 0.1 5.2e-35 120.5 0.0 1.6 2 0 0 2 2 2 1 RhoGAP domain Iso_dh PF00180.20 KOG96635.1 - 2.1e-104 349.4 0.0 2.7e-104 349.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Metallophos PF00149.28 KOG96636.1 - 4.6e-15 56.7 0.3 4.4e-14 53.5 0.0 2.3 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase DUF4160 PF13711.6 KOG96636.1 - 0.13 12.6 0.1 4.1 7.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4160) UBA PF00627.31 KOG96637.1 - 8.2e-09 35.2 0.0 1.9e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.6 KOG96637.1 - 0.00031 20.5 0.0 0.00077 19.2 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain CUE PF02845.16 KOG96637.1 - 0.022 14.5 0.1 0.11 12.2 0.0 2.4 2 1 0 2 2 2 0 CUE domain PsiA PF06952.11 KOG96637.1 - 0.041 13.1 0.0 0.075 12.3 0.0 1.3 1 0 0 1 1 1 0 PsiA protein V-ATPase_G PF03179.15 KOG96637.1 - 0.16 12.5 3.3 0.53 10.8 3.3 1.8 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit RNA_pol_Rpb4 PF03874.16 KOG96637.1 - 0.25 11.7 3.0 0.69 10.2 3.0 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb4 AATF-Che1 PF13339.6 KOG96637.1 - 0.37 11.5 4.1 2.5 8.8 0.4 2.4 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor HSF_DNA-bind PF00447.17 KOG96638.1 - 3.3e-28 98.2 0.3 3.3e-28 98.2 0.3 3.3 3 0 0 3 3 3 1 HSF-type DNA-binding CLN3 PF02487.17 KOG96638.1 - 0.94 8.5 11.1 2.1 7.3 11.1 1.5 1 0 0 1 1 1 0 CLN3 protein Noggin PF05806.12 KOG96638.1 - 0.94 9.4 7.4 2 8.3 7.4 1.5 1 0 0 1 1 1 0 Noggin PepSY_TM PF03929.16 KOG96638.1 - 2.2 7.8 7.3 2.1 7.9 6.0 1.7 2 0 0 2 2 2 0 PepSY-associated TM region Serinc PF03348.15 KOG96638.1 - 2.4 7.0 5.4 4.2 6.2 5.4 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4407 PF14362.6 KOG96638.1 - 2.5 7.4 9.1 4.4 6.6 9.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OATP PF03137.20 KOG96638.1 - 2.5 6.3 7.9 4.2 5.5 7.9 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF853 PF05872.12 KOG96638.1 - 3.4 6.1 8.4 5.2 5.6 8.4 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) CCSAP PF15748.5 KOG96638.1 - 5.1 7.2 25.6 1.3 9.2 16.0 2.5 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Presenilin PF01080.17 KOG96638.1 - 5.2 5.7 24.3 0.053 12.3 12.0 2.2 2 0 0 2 2 2 0 Presenilin DUF5523 PF17661.1 KOG96638.1 - 6.5 6.4 20.1 1.7 8.3 12.6 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Actin PF00022.19 KOG96639.1 - 8.6e-27 93.8 0.0 1.8e-20 72.9 0.0 3.3 2 2 0 2 2 2 2 Actin Actin_micro PF17003.5 KOG96639.1 - 9.8e-14 51.3 4.7 1.3e-06 27.9 0.2 2.8 2 2 0 2 2 2 2 Putative actin-like family MreB_Mbl PF06723.13 KOG96639.1 - 0.00057 18.8 0.0 0.016 14.0 0.0 2.3 2 0 0 2 2 2 1 MreB/Mbl protein SDA1 PF05285.12 KOG96639.1 - 0.002 17.6 23.1 0.0051 16.3 23.1 1.6 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 KOG96639.1 - 0.077 11.2 28.4 0.15 10.2 28.4 1.4 1 0 0 1 1 1 0 Nop14-like family DUF2098 PF09871.9 KOG96639.1 - 4.2 7.8 0.0 4.2 7.8 0.0 3.8 5 0 0 5 5 5 0 Uncharacterized protein conserved in archaea (DUF2098) CoA_binding PF02629.19 KOG96640.1 - 4.4e-28 97.8 3.1 4.6e-28 97.7 1.3 2.0 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 KOG96640.1 - 1.6e-24 86.5 0.7 2.6e-24 85.8 0.7 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 KOG96640.1 - 4.6e-08 33.0 0.7 7.3e-08 32.3 0.1 1.6 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 KOG96640.1 - 7e-07 29.7 0.0 1.3e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 CoA binding domain IlvN PF07991.12 KOG96640.1 - 0.045 13.3 0.5 0.46 10.0 0.0 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain TPK_catalytic PF04263.16 KOG96641.1 - 1.1e-31 109.3 0.4 4.5e-31 107.4 0.4 1.9 1 1 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 KOG96641.1 - 1.5e-13 50.2 0.1 3.9e-13 48.9 0.1 1.7 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain CEND1 PF15677.5 KOG96642.1 - 0.04 14.5 0.5 0.083 13.4 0.5 1.4 1 0 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 BAF PF02961.14 KOG96642.1 - 0.068 13.6 0.8 0.76 10.3 0.7 2.5 2 0 0 2 2 2 0 Barrier to autointegration factor KH_8 PF17903.1 KOG96643.1 - 1.2e-06 28.5 0.0 2.3e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 KOG96643.1 - 0.062 13.1 0.2 0.23 11.3 0.2 1.9 1 0 0 1 1 1 0 KH domain MDM31_MDM32 PF08118.11 KOG96644.1 - 2.7e-58 198.0 27.0 2.8e-29 102.2 5.6 4.1 1 1 3 4 4 4 4 Yeast mitochondrial distribution and morphology (MDM) proteins DUF3139 PF11337.8 KOG96644.1 - 0.19 12.4 5.5 3 8.6 0.5 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) G-patch_2 PF12656.7 KOG96645.1 - 5.8e-17 61.5 0.2 5.8e-17 61.5 0.2 2.0 2 0 0 2 2 2 1 G-patch domain DUF3245 PF11595.8 KOG96645.1 - 0.0083 16.6 0.3 0.0083 16.6 0.3 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF3245) Glyco_transf_22 PF03901.17 KOG96646.1 - 9e-84 282.1 30.6 1.1e-83 281.9 30.6 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF2142 PF09913.9 KOG96646.1 - 0.0026 16.7 17.7 0.0037 16.2 17.7 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2142) DUF624 PF04854.14 KOG96646.1 - 4.8 7.4 12.1 2.1 8.5 0.3 4.3 4 0 0 4 4 4 0 Protein of unknown function, DUF624 Ribosomal_L13 PF00572.18 KOG96647.1 - 3.6e-45 153.2 0.2 4.5e-45 152.9 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 RNA_pol_Rpb2_6 PF00562.28 KOG96648.1 - 3.1e-126 421.6 0.2 5.1e-126 420.9 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 KOG96648.1 - 4.4e-73 245.1 0.0 7.5e-73 244.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 KOG96648.1 - 1.6e-51 174.7 0.0 2.8e-51 173.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 KOG96648.1 - 9e-34 115.7 0.1 2e-33 114.6 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 KOG96648.1 - 9e-26 90.0 0.3 2e-25 88.8 0.3 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 KOG96648.1 - 2.5e-24 85.2 0.1 6.4e-24 83.9 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 KOG96648.1 - 9.6e-20 70.9 1.0 9.6e-20 70.9 1.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 Secretin_N_2 PF07655.13 KOG96649.1 - 0.045 14.3 4.0 0.09 13.3 4.0 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain ABC2_membrane PF01061.24 KOG96650.1 - 1.5e-81 272.8 61.4 8.1e-46 156.1 24.7 2.5 3 0 0 3 3 2 2 ABC-2 type transporter ABC_tran PF00005.27 KOG96650.1 - 1.6e-39 135.5 0.1 3.8e-18 66.3 0.0 3.3 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 KOG96650.1 - 2.6e-33 113.8 13.7 3.1e-31 107.1 0.3 3.8 3 0 0 3 3 3 2 CDR ABC transporter ABC_trans_N PF14510.6 KOG96650.1 - 9.1e-21 74.3 0.9 2.9e-20 72.7 0.0 2.3 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_16 PF13191.6 KOG96650.1 - 3.7e-08 33.9 0.0 1.6e-05 25.3 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 KOG96650.1 - 1.6e-07 31.1 0.2 2.1e-05 24.2 0.0 3.0 4 0 0 4 4 3 1 AAA domain AAA_18 PF13238.6 KOG96650.1 - 3.5e-06 27.6 0.4 0.0024 18.4 0.0 3.0 3 0 0 3 3 2 1 AAA domain RsgA_GTPase PF03193.16 KOG96650.1 - 1.9e-05 24.6 0.1 0.0012 18.8 0.0 3.0 3 0 0 3 3 3 1 RsgA GTPase AAA_33 PF13671.6 KOG96650.1 - 0.00021 21.5 0.0 0.073 13.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 KOG96650.1 - 0.00025 20.6 0.1 0.0052 16.2 0.0 2.9 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KOG96650.1 - 0.00034 20.5 0.0 0.2 11.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOG96650.1 - 0.00038 20.2 0.4 0.0078 15.9 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain cobW PF02492.19 KOG96650.1 - 0.0011 18.6 0.7 0.33 10.5 0.0 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 KOG96650.1 - 0.0025 18.4 0.4 0.045 14.2 0.0 2.9 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 KOG96650.1 - 0.0031 17.4 0.3 2.8 7.8 0.1 2.6 2 0 0 2 2 2 2 NACHT domain AAA_28 PF13521.6 KOG96650.1 - 0.005 17.1 0.3 0.21 11.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOG96650.1 - 0.0083 16.4 2.9 0.51 10.6 0.2 3.6 5 0 0 5 5 4 1 AAA domain AAA_13 PF13166.6 KOG96650.1 - 0.012 14.3 3.9 2.9 6.4 0.0 3.7 5 0 0 5 5 5 0 AAA domain DnaB_C PF03796.15 KOG96650.1 - 0.017 14.5 0.0 0.64 9.3 0.0 2.3 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_30 PF13604.6 KOG96650.1 - 0.034 13.9 0.4 3.2 7.4 0.2 2.4 2 0 0 2 2 2 0 AAA domain MSC PF09402.10 KOG96650.1 - 0.041 13.3 0.0 0.42 10.0 0.1 2.3 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain OCD_Mu_crystall PF02423.15 KOG96650.1 - 0.11 11.5 0.1 0.37 9.7 0.0 1.8 2 0 0 2 2 2 0 Ornithine cyclodeaminase/mu-crystallin family NB-ARC PF00931.22 KOG96650.1 - 0.17 11.1 0.1 7.8 5.6 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain AAA_17 PF13207.6 KOG96650.1 - 0.19 12.1 1.4 2.2 8.7 0.0 2.9 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 KOG96650.1 - 0.24 11.8 1.1 31 5.0 0.0 3.4 4 0 0 4 4 2 0 RNA helicase Sad1_UNC PF07738.13 KOG96651.1 - 8.6e-31 106.7 0.1 1.8e-30 105.6 0.1 1.6 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal ISN1 PF06437.11 KOG96652.1 - 1.9e-179 596.9 0.0 2.1e-179 596.7 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase PINIT PF14324.6 KOG96653.1 - 3e-25 89.3 0.1 9.1e-25 87.7 0.1 1.8 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 KOG96653.1 - 5.5e-21 74.1 10.8 9.6e-21 73.3 10.8 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.27 KOG96653.1 - 3.2e-09 36.3 0.9 5.6e-09 35.6 0.9 1.4 1 0 0 1 1 1 1 SAP domain zf-Nse PF11789.8 KOG96653.1 - 1.4e-05 24.8 4.3 4.5e-05 23.2 4.3 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 KOG96653.1 - 0.012 15.6 3.8 0.012 15.6 3.8 2.2 1 1 1 2 2 2 0 RING-type zinc-finger Prok-RING_4 PF14447.6 KOG96653.1 - 0.37 10.7 5.3 0.8 9.6 5.3 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KOG96653.1 - 0.8 10.1 8.0 1.6 9.1 8.0 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 KOG96653.1 - 6.3 6.7 9.7 22 5.0 9.7 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Proteasome PF00227.26 KOG96654.1 - 1.9e-49 167.8 0.1 2.8e-49 167.2 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 KOG96654.1 - 3.3e-15 55.2 0.0 3.3e-15 55.2 0.0 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal RGS_DHEX PF18148.1 KOG96655.1 - 0.54 10.4 4.2 0.35 11.0 0.3 2.2 2 0 0 2 2 2 0 Regulator of G-protein signalling DHEX domain LSM PF01423.22 KOG96656.1 - 2.5e-14 52.7 0.1 3e-14 52.4 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 KOG96656.1 - 0.0006 19.4 0.1 0.00098 18.7 0.1 1.3 1 0 0 1 1 1 1 Hfq protein Xpo1 PF08389.12 KOG96657.1 - 5.5e-27 94.7 7.2 5.5e-27 94.7 7.2 3.6 4 0 0 4 4 4 1 Exportin 1-like protein IBN_N PF03810.19 KOG96657.1 - 6.1e-05 22.9 2.4 0.00025 20.9 1.0 3.0 2 0 0 2 2 2 1 Importin-beta N-terminal domain Choline_transpo PF04515.12 KOG96658.1 - 5.3e-76 255.9 19.8 5.3e-76 255.9 19.8 2.2 2 0 0 2 2 2 1 Plasma-membrane choline transporter TauE PF01925.19 KOG96658.1 - 6.3 6.3 26.3 0.05 13.2 8.6 3.1 3 1 0 3 3 3 0 Sulfite exporter TauE/SafE DUF1749 PF08538.10 KOG96659.1 - 2.2e-98 329.1 0.0 2.5e-98 328.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.8 KOG96659.1 - 2.9e-07 30.0 0.2 7e-05 22.2 0.1 2.4 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOG96659.1 - 0.0002 21.1 0.1 0.0023 17.6 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOG96659.1 - 0.00058 19.4 0.0 0.51 9.8 0.0 2.5 1 1 1 3 3 3 2 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 KOG96659.1 - 0.0089 15.0 0.0 0.014 14.3 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Ser_hydrolase PF06821.13 KOG96659.1 - 0.076 12.9 0.0 1.7 8.5 0.0 2.4 1 1 1 2 2 2 0 Serine hydrolase LIDHydrolase PF10230.9 KOG96659.1 - 0.13 11.7 0.1 0.85 9.1 0.0 1.9 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Chlorophyllase PF07224.11 KOG96659.1 - 0.18 10.8 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Zn_clus PF00172.18 KOG96660.1 - 3.1e-09 36.8 9.6 6.9e-09 35.7 9.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 KOG96660.1 - 0.039 13.0 1.3 0.28 10.2 1.3 2.2 1 1 0 1 1 1 0 Fungal specific transcription factor domain NUDIX PF00293.28 KOG96661.1 - 2.6e-19 69.6 0.3 3.5e-19 69.2 0.3 1.2 1 0 0 1 1 1 1 NUDIX domain DUF410 PF04190.13 KOG96662.1 - 1.5e-78 264.1 1.7 1.9e-78 263.8 1.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) DUF2802 PF10975.8 KOG96662.1 - 0.033 14.3 0.2 0.069 13.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) RHD3 PF05879.12 KOG96663.1 - 8.2e-288 956.6 13.3 9.4e-288 956.4 13.3 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 KOG96663.1 - 8e-05 22.7 0.1 0.00024 21.2 0.1 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 KOG96663.1 - 0.00016 21.8 0.2 0.0006 19.9 0.0 2.1 2 0 0 2 2 2 1 Dynamin family Septin PF00735.18 KOG96663.1 - 0.022 14.1 0.4 0.075 12.3 0.0 2.1 2 0 0 2 2 2 0 Septin Roc PF08477.13 KOG96663.1 - 0.34 11.1 2.0 0.57 10.4 0.1 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PIN_4 PF13638.6 KOG96664.1 - 6.6e-33 113.8 0.0 1.5e-32 112.6 0.0 1.6 1 0 0 1 1 1 1 PIN domain PIN_9 PF18477.1 KOG96664.1 - 0.071 13.4 0.0 1.7 9.0 0.0 2.5 2 0 0 2 2 2 0 PIN like domain Ribosomal_S28e PF01200.18 KOG96665.1 - 7e-32 109.2 2.9 7.8e-32 109.1 2.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e tRNA-synt_1c PF00749.21 KOG96666.1 - 2.5e-116 388.0 0.0 4e-116 387.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 KOG96666.1 - 1.1e-51 175.0 0.8 1.9e-51 174.3 0.8 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 KOG96666.1 - 3.1e-32 111.8 0.2 5.2e-31 107.9 0.0 2.5 1 1 1 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 KOG96666.1 - 3e-15 56.9 4.2 8.1e-15 55.5 4.2 1.7 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DAGK_cat PF00781.24 KOG96667.1 - 6.6e-27 93.6 0.0 1.1e-26 92.9 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Zn_clus PF00172.18 KOG96668.1 - 1.5e-07 31.4 9.9 3.7e-07 30.2 9.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DcpS_C PF11969.8 KOG96669.1 - 1.4e-34 119.0 0.2 2.8e-34 118.0 0.2 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 KOG96669.1 - 1.7e-31 109.1 0.0 2.6e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal Vault_4 PF17796.1 KOG96669.1 - 0.063 13.4 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Major Vault Protein repeat domain Med4 PF10018.9 KOG96670.1 - 7e-34 117.2 3.2 7e-34 117.2 3.2 1.8 3 0 0 3 3 3 1 Vitamin-D-receptor interacting Mediator subunit 4 MBOAT PF03062.19 KOG96671.1 - 1.2e-82 278.1 9.0 2e-82 277.3 9.0 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Ferrochelatase PF00762.19 KOG96672.1 - 1.9e-98 329.5 0.0 2.2e-98 329.3 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase TetR_C_4 PF08359.11 KOG96673.1 - 0.0059 16.7 0.9 0.0059 16.7 0.9 3.1 4 0 0 4 4 4 2 YsiA-like protein, C-terminal region UPF0449 PF15136.6 KOG96673.1 - 0.039 14.4 0.8 0.039 14.4 0.8 5.3 1 1 4 5 5 5 0 Uncharacterised protein family UPF0449 HemN_C PF06969.16 KOG96673.1 - 0.13 12.3 1.8 0.24 11.5 0.2 2.3 2 1 0 2 2 2 0 HemN C-terminal domain LMWPc PF01451.21 KOG96673.1 - 0.51 10.7 0.0 0.51 10.7 0.0 3.2 2 1 0 3 3 3 0 Low molecular weight phosphotyrosine protein phosphatase CBM_21 PF03370.13 KOG96674.1 - 1.8e-25 89.3 5.3 5.2e-25 87.8 5.3 1.9 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 KOG96674.1 - 0.0015 19.1 6.5 0.0015 19.1 6.5 3.0 2 1 0 2 2 2 1 Starch/carbohydrate-binding module (family 53) CPSF73-100_C PF11718.8 KOG96675.1 - 6.5e-23 81.4 1.1 8.1e-23 81.1 1.1 1.1 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term EDR1 PF14381.6 KOG96675.1 - 0.076 12.7 0.6 0.097 12.4 0.6 1.2 1 0 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 ECH_1 PF00378.20 KOG96676.1 - 1.8e-17 63.5 0.0 6.8e-17 61.6 0.0 1.8 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KOG96676.1 - 1.2e-09 38.2 0.0 1.6e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase SPA PF08616.10 KOG96676.1 - 0.021 14.8 0.1 0.038 14.0 0.1 1.5 1 0 0 1 1 1 0 Stabilization of polarity axis WH1 PF00568.23 KOG96677.1 - 2.8e-36 123.8 0.0 3.9e-36 123.4 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 KOG96677.1 - 1.2e-06 28.2 1.7 2.5e-06 27.1 1.7 1.6 1 0 0 1 1 1 1 WH2 motif Aminotran_5 PF00266.19 KOG96678.1 - 5.5e-37 127.6 0.0 6.9e-37 127.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Ras PF00071.22 KOG96679.1 - 1.6e-51 174.1 0.0 1.9e-51 173.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG96679.1 - 1.4e-31 109.2 0.1 3.6e-31 107.9 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG96679.1 - 4.7e-12 45.7 0.0 6.3e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 KOG96679.1 - 0.00029 21.2 0.2 0.0023 18.3 0.2 2.1 1 1 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.23 KOG96679.1 - 0.00046 20.3 0.0 0.0009 19.3 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOG96679.1 - 0.0013 18.2 0.0 0.0017 17.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOG96679.1 - 0.0022 17.6 0.3 0.0092 15.5 0.3 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KOG96679.1 - 0.011 15.2 0.0 0.018 14.5 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KOG96679.1 - 0.013 14.7 2.3 1.6 7.8 0.1 2.9 2 1 1 3 3 3 0 G-protein alpha subunit Pox_A32 PF04665.12 KOG96679.1 - 0.019 14.4 0.1 0.036 13.5 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein ATPase PF06745.13 KOG96679.1 - 0.019 14.3 0.2 0.031 13.6 0.2 1.2 1 0 0 1 1 1 0 KaiC RsgA_GTPase PF03193.16 KOG96679.1 - 0.022 14.7 0.1 6.8 6.6 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 KOG96679.1 - 0.03 13.8 0.1 0.051 13.1 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ArgoMid PF16487.5 KOG96679.1 - 0.032 14.5 0.1 0.07 13.4 0.1 1.6 1 0 0 1 1 1 0 Mid domain of argonaute AAA_24 PF13479.6 KOG96679.1 - 0.066 12.9 0.3 0.13 12.0 0.3 1.5 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 KOG96679.1 - 0.082 12.9 0.1 0.21 11.6 0.1 1.6 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 KOG96679.1 - 0.092 12.9 0.2 0.23 11.6 0.2 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOG96679.1 - 0.12 12.7 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 KOG96679.1 - 0.15 11.3 0.3 0.25 10.6 0.0 1.6 2 0 0 2 2 2 0 Septin GTP_EFTU PF00009.27 KOG96681.1 - 9.5e-59 198.2 0.2 1.2e-58 197.8 0.2 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KOG96681.1 - 5.8e-28 97.4 0.0 1.1e-27 96.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KOG96681.1 - 7.1e-19 68.0 1.1 1.7e-18 66.7 1.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOG96681.1 - 5.5e-05 23.2 0.0 0.00011 22.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG96681.1 - 0.014 15.3 0.2 0.043 13.7 0.0 1.8 1 1 1 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 KOG96681.1 - 0.036 13.8 0.3 11 5.8 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 KOG96681.1 - 0.071 12.7 0.0 0.071 12.7 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Cellulase PF00150.18 KOG96683.1 - 1e-12 48.1 0.7 8.1e-12 45.1 0.4 2.0 1 1 1 2 2 2 1 Cellulase (glycosyl hydrolase family 5) SNF2_N PF00176.23 KOG96684.1 - 1e-54 185.6 0.0 1e-54 185.6 0.0 2.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOG96684.1 - 5e-16 59.0 0.0 3.1e-15 56.5 0.0 2.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 KOG96684.1 - 4e-05 23.5 2.7 9.7e-05 22.3 2.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOG96684.1 - 0.00026 21.0 0.7 0.00062 19.7 0.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger ResIII PF04851.15 KOG96684.1 - 0.0012 18.8 0.1 0.0012 18.8 0.1 3.6 3 1 0 3 3 2 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 KOG96684.1 - 0.0031 17.4 1.6 0.0076 16.1 1.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOG96684.1 - 0.0036 17.6 2.3 0.0092 16.3 2.3 1.7 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KOG96684.1 - 0.0062 16.4 2.0 0.014 15.2 2.0 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KOG96684.1 - 0.0065 16.3 1.3 0.015 15.2 1.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOG96684.1 - 0.035 14.0 2.3 0.076 12.9 2.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) AAA_22 PF13401.6 KOG96684.1 - 1.7 9.0 6.1 0.33 11.2 0.8 2.7 3 0 0 3 3 3 0 AAA domain DUF959 PF06121.14 KOG96685.1 - 0.0039 17.5 0.0 0.0058 16.9 0.0 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF959) PEX11 PF05648.14 KOG96685.1 - 0.013 15.0 7.3 0.034 13.6 7.4 1.7 1 1 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Sushi PF00084.20 KOG96685.1 - 0.075 13.6 0.1 6.9 7.4 0.0 2.4 2 0 0 2 2 2 0 Sushi repeat (SCR repeat) TFIIA PF03153.13 KOG96686.1 - 1.5e-47 163.5 24.2 1.1e-26 94.8 15.9 2.0 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Fungal_TACC PF12709.7 KOG96687.1 - 1e-31 109.2 15.9 1e-31 109.2 15.9 9.5 4 2 5 9 9 9 1 Fungal Transforming acidic coiled-coil (TACC) proteins HrpB7 PF09486.10 KOG96687.1 - 5.6e-06 26.8 6.2 0.0031 17.9 0.1 4.4 4 0 0 4 4 4 1 Bacterial type III secretion protein (HrpB7) Spc7 PF08317.11 KOG96687.1 - 0.0014 17.5 102.1 0.018 13.9 10.3 5.9 2 1 4 6 6 6 3 Spc7 kinetochore protein ATG16 PF08614.11 KOG96687.1 - 0.0083 16.4 14.3 0.0083 16.4 14.3 6.6 2 1 4 7 7 7 5 Autophagy protein 16 (ATG16) Hema_stalk PF08720.10 KOG96687.1 - 0.46 10.2 6.2 8.7 6.0 2.8 3.2 1 1 1 2 2 2 0 Influenza C hemagglutinin stalk LPP PF04728.13 KOG96687.1 - 2.6 8.5 45.8 0.83 10.1 0.1 8.7 9 0 0 9 9 9 0 Lipoprotein leucine-zipper DUF4407 PF14362.6 KOG96687.1 - 3.1 7.1 55.1 0.82 9.0 3.1 5.0 1 1 1 3 3 3 0 Domain of unknown function (DUF4407) LIAS_N PF16881.5 KOG96688.1 - 1.8e-23 83.0 0.1 2e-22 79.7 0.1 2.2 2 0 0 2 2 2 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 KOG96688.1 - 4e-13 50.1 0.1 8.5e-13 49.0 0.1 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Peptidase_C14 PF00656.22 KOG96689.1 - 9.2e-63 212.5 0.0 1.2e-62 212.1 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Tox-HDC PF15656.6 KOG96689.1 - 0.099 12.8 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Toxin with a H, D/N and C signature MutL PF13941.6 KOG96689.1 - 0.14 10.7 0.2 0.21 10.2 0.2 1.2 1 0 0 1 1 1 0 MutL protein SpoU_methylase PF00588.19 KOG96691.1 - 6.5e-25 88.0 0.0 1.8e-24 86.5 0.0 1.8 1 1 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 KOG96691.1 - 5e-13 49.1 0.0 1.2e-12 48.0 0.0 1.7 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding IGPD PF00475.18 KOG96692.1 - 1e-61 207.4 0.6 1.6e-61 206.8 0.6 1.3 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase DEAD PF00270.29 KOG96693.1 - 2.1e-50 170.9 0.0 4.7e-50 169.8 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG96693.1 - 2.4e-33 114.8 0.0 3.6e-32 111.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG96693.1 - 0.0096 15.9 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOG96693.1 - 0.017 14.3 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 KOG96693.1 - 0.076 12.3 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit UTP25 PF06862.12 KOG96693.1 - 0.15 10.8 0.0 0.34 9.6 0.0 1.5 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 MMR_HSR1 PF01926.23 KOG96694.1 - 1.9e-08 34.4 0.0 1.2e-07 31.8 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG96694.1 - 1.2e-05 25.3 0.0 3.5e-05 23.8 0.0 1.8 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 KOG96694.1 - 0.0019 17.7 0.0 0.0079 15.7 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 KOG96694.1 - 0.054 13.0 0.1 4.7 6.7 0.1 2.4 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain RNA_helicase PF00910.22 KOG96694.1 - 0.07 13.5 0.0 0.23 11.9 0.0 1.9 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 KOG96694.1 - 0.084 13.4 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Roc PF08477.13 KOG96694.1 - 0.091 13.0 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase zf-AD PF07776.15 KOG96694.1 - 0.59 10.4 2.8 1.4 9.2 0.1 2.9 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) Noc2 PF03715.13 KOG96695.1 - 4.2e-127 423.5 3.0 4.2e-127 423.5 3.0 2.1 2 0 0 2 2 2 1 Noc2p family DUF4048 PF13257.6 KOG96695.1 - 4.6 7.0 13.5 9.1 6.0 13.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4048) NPAT_C PF15712.5 KOG96695.1 - 8.4 4.9 17.7 17 3.9 17.7 1.4 1 0 0 1 1 1 0 NPAT C terminus RNA_pol_Rpb2_6 PF00562.28 KOG96696.1 - 5.8e-125 417.4 0.2 5.8e-125 417.4 0.2 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 KOG96696.1 - 7.5e-63 211.7 1.1 1.2e-62 211.1 1.1 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 KOG96696.1 - 8.8e-44 149.4 3.4 2.3e-43 148.1 3.4 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 KOG96696.1 - 6.1e-34 116.3 0.2 1.8e-33 114.8 0.2 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 KOG96696.1 - 6.2e-25 87.3 0.2 2.7e-24 85.2 0.2 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 KOG96696.1 - 2e-18 66.3 0.0 4.4e-18 65.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 KOG96696.1 - 8.1e-10 39.1 1.4 4.4e-09 36.8 1.4 2.4 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 5 TraI_2_C PF07515.11 KOG96696.1 - 0.087 12.8 0.2 0.21 11.5 0.2 1.6 1 0 0 1 1 1 0 Putative conjugal transfer nickase/helicase TraI C-term Glyco_hydro_72 PF03198.14 KOG96696.1 - 0.099 11.9 0.1 0.37 10.0 0.1 1.8 1 1 0 1 1 1 0 Glucanosyltransferase DUF370 PF04025.12 KOG96696.1 - 0.14 12.3 1.8 0.27 11.4 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF370) Y_phosphatase PF00102.27 KOG96697.1 - 2.3e-69 233.5 0.5 4.2e-69 232.7 0.5 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KOG96697.1 - 0.0036 17.3 0.0 0.0088 16.0 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 KOG96697.1 - 0.067 13.0 0.0 0.26 11.1 0.0 2.0 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain NAPRTase PF04095.16 KOG96698.1 - 2e-79 266.6 0.1 3.3e-79 265.9 0.1 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 KOG96698.1 - 2.4e-34 118.4 0.2 4.1e-34 117.6 0.2 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain RNA_pol_N PF01194.17 KOG96699.1 - 8.5e-30 102.8 0.3 9.7e-30 102.7 0.3 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 KOG96699.1 - 0.036 14.3 0.2 0.048 13.9 0.2 1.3 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Dynamin_N PF00350.23 KOG96700.1 - 1.9e-42 145.2 0.2 1.9e-42 145.2 0.2 2.3 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 KOG96700.1 - 1.1e-06 28.7 0.4 6.9e-05 22.9 0.1 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_M PF01031.20 KOG96700.1 - 0.0032 16.8 6.9 0.13 11.4 0.0 3.5 3 0 0 3 3 3 2 Dynamin central region AKAP7_RIRII_bdg PF10470.9 KOG96700.1 - 0.039 14.0 0.1 0.46 10.6 0.0 2.6 2 0 0 2 2 2 0 PKA-RI-RII subunit binding domain of A-kinase anchor protein AAA_16 PF13191.6 KOG96700.1 - 0.046 14.1 0.1 0.15 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 KOG96700.1 - 0.098 12.9 0.0 0.37 11.0 0.0 2.0 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DUF1140 PF06600.11 KOG96700.1 - 0.14 12.6 5.7 5.5 7.5 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1140) CENP-B_dimeris PF09026.10 KOG96700.1 - 1 9.8 9.4 0.74 10.2 7.2 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 KOG96700.1 - 4.5 6.3 9.6 8 5.5 8.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 KOG96700.1 - 8.7 5.6 10.1 17 4.6 10.1 1.4 1 0 0 1 1 1 0 NOA36 protein WD40 PF00400.32 KOG96701.1 - 1.1e-30 105.2 17.6 2.9e-06 27.9 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG96701.1 - 1.5e-09 38.1 0.1 0.92 9.8 0.0 5.0 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOG96701.1 - 0.018 14.4 0.8 0.68 9.2 0.0 2.9 3 0 0 3 3 3 0 WD40-like domain VIT_2 PF13757.6 KOG96701.1 - 0.095 12.6 0.1 0.26 11.2 0.1 1.7 1 0 0 1 1 1 0 Vault protein inter-alpha-trypsin domain YEATS PF03366.16 KOG96702.1 - 7.2e-21 74.0 0.0 1.3e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 YEATS family DUF3305 PF11749.8 KOG96703.1 - 0.17 12.0 0.0 0.31 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3305) YqeY PF09424.10 KOG96704.1 - 9.8e-20 71.1 5.2 1.4e-19 70.6 5.2 1.2 1 0 0 1 1 1 1 Yqey-like protein Pox_A3L PF05288.11 KOG96704.1 - 0.025 14.5 0.8 0.071 13.1 0.2 2.0 2 0 0 2 2 2 0 Poxvirus A3L Protein LZ3wCH PF18517.1 KOG96704.1 - 0.037 14.1 1.8 0.19 11.9 0.2 2.5 2 0 0 2 2 2 0 Leucine zipper with capping helix domain GRAB PF10375.9 KOG96705.1 - 4.5e-07 29.5 1.6 1.3e-06 28.0 1.6 1.9 1 0 0 1 1 1 1 GRIP-related Arf-binding domain GAS PF13851.6 KOG96705.1 - 0.45 9.8 82.3 0.091 12.1 21.5 4.6 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding Filo_VP35 PF02097.15 KOG96705.1 - 1.2 8.2 8.2 0.66 9.0 0.3 2.5 2 1 0 2 2 2 0 Filoviridae VP35 DUF3584 PF12128.8 KOG96705.1 - 1.4 6.3 66.7 0.0061 14.1 37.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Tup_N PF08581.10 KOG96705.1 - 1.5 9.1 67.7 0.23 11.8 9.4 5.6 3 1 2 5 5 5 0 Tup N-terminal PhageMin_Tail PF10145.9 KOG96705.1 - 4 7.2 10.0 0.14 12.0 0.5 3.1 2 2 1 3 3 3 0 Phage-related minor tail protein RFC1 PF08519.12 KOG96706.1 - 1.5e-58 197.4 0.1 4.1e-57 192.8 0.0 2.4 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain AAA PF00004.29 KOG96706.1 - 1.5e-12 48.1 0.0 4.1e-12 46.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 KOG96706.1 - 7.8e-11 42.2 0.0 4.7e-10 39.7 0.0 2.5 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain RuvB_N PF05496.12 KOG96706.1 - 2.2e-05 24.3 0.0 4.5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 KOG96706.1 - 5.3e-05 23.2 0.0 0.00014 21.8 0.0 1.8 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 KOG96706.1 - 0.00038 20.9 0.0 0.0014 19.0 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOG96706.1 - 0.00044 20.5 0.0 0.0033 17.7 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOG96706.1 - 0.00084 19.9 0.0 0.0025 18.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 KOG96706.1 - 0.0011 19.3 0.0 0.0033 17.7 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_33 PF13671.6 KOG96706.1 - 0.0014 18.8 0.0 0.0038 17.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KOG96706.1 - 0.0023 18.3 0.0 0.0076 16.6 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 KOG96706.1 - 0.0038 17.3 0.0 0.016 15.3 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.6 KOG96706.1 - 0.005 17.3 0.0 0.005 17.3 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_24 PF13479.6 KOG96706.1 - 0.028 14.2 0.0 0.068 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KOG96706.1 - 0.047 13.7 0.0 0.91 9.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 KOG96706.1 - 0.07 13.0 0.0 0.35 10.8 0.0 2.1 2 0 0 2 2 2 0 NACHT domain NTPase_1 PF03266.15 KOG96706.1 - 0.097 12.6 0.1 0.44 10.4 0.0 2.2 3 0 0 3 3 3 0 NTPase AAA_11 PF13086.6 KOG96706.1 - 0.42 10.3 0.0 0.42 10.3 0.0 2.9 4 0 0 4 4 4 0 AAA domain SAT PF16073.5 KOG96708.1 - 0.0013 18.5 0.0 0.0018 18.0 0.0 1.2 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 KOG96708.1 - 0.095 12.2 0.0 0.24 10.9 0.0 1.6 2 0 0 2 2 2 0 Acyl transferase domain Mito_carr PF00153.27 KOG96709.1 - 2.4e-65 216.5 2.5 4.4e-24 84.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOG96709.1 - 0.46 9.6 3.9 6.6 5.8 0.0 3.5 2 2 1 4 4 4 0 Gammaproteobacterial serine protease Tim17 PF02466.19 KOG96709.1 - 0.48 10.8 2.9 2.1 8.8 2.9 2.4 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family DUF2407_C PF13373.6 KOG96710.1 - 1.7e-45 154.7 0.7 2.7e-45 154.0 0.7 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 KOG96710.1 - 1.2e-20 74.0 0.0 2.3e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain RNA_pol_Rpb8 PF03870.15 KOG96711.1 - 1.8e-45 154.5 0.0 2e-45 154.4 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 KOG96711.1 - 0.00055 20.0 0.1 0.39 10.8 0.0 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G NifU_N PF01592.16 KOG96712.1 - 1.7e-56 189.9 0.1 2e-56 189.6 0.1 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain TSCPD PF12637.7 KOG96712.1 - 0.012 15.9 0.2 0.023 14.9 0.2 1.4 1 0 0 1 1 1 0 TSCPD domain Vip3A_N PF12495.8 KOG96713.1 - 0.069 13.0 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 Vegetative insecticide protein 3A N terminal LRR_4 PF12799.7 KOG96713.1 - 2.1 8.9 7.8 0.68 10.4 0.6 4.1 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) DUF1691 PF07950.11 KOG96714.1 - 8.1e-32 110.1 1.3 1.6e-17 64.2 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) Sdh_cyt PF01127.22 KOG96714.1 - 6.5e-09 35.9 1.0 0.00052 20.0 0.8 2.2 2 0 0 2 2 2 2 Succinate dehydrogenase/Fumarate reductase transmembrane subunit WD40 PF00400.32 KOG96715.1 - 0.00028 21.6 4.8 0.015 16.1 0.4 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 KOG96716.1 - 0.00014 22.6 6.0 0.016 16.0 0.3 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat Pkinase PF00069.25 KOG96717.1 - 2.4e-72 243.5 0.0 3.1e-72 243.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96717.1 - 1.2e-37 129.6 0.0 2.4e-37 128.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG96717.1 - 8.8e-08 31.8 0.0 1.8e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 KOG96717.1 - 2.4e-05 24.1 0.1 0.12 12.0 0.0 2.2 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 KOG96717.1 - 0.00061 18.7 0.0 0.0011 17.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOG96717.1 - 0.0044 16.4 0.0 0.007 15.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOG96717.1 - 0.005 16.8 0.0 0.18 11.7 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family TcpS PF17456.2 KOG96717.1 - 0.0078 16.3 0.0 1.1 9.3 0.0 2.3 2 0 0 2 2 2 1 Toxin-coregulated pilus protein S Seadorna_VP7 PF07387.11 KOG96717.1 - 0.014 14.4 0.0 0.031 13.3 0.0 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 KOG96717.1 - 0.022 13.7 0.4 0.05 12.5 0.4 1.8 1 1 0 1 1 1 0 Haspin like kinase domain GrpE PF01025.19 KOG96718.1 - 2.2e-49 167.3 7.6 2.7e-49 167.0 7.6 1.1 1 0 0 1 1 1 1 GrpE MogR_DNAbind PF12181.8 KOG96718.1 - 0.0043 17.0 1.6 0.0062 16.5 1.0 1.5 1 1 0 1 1 1 1 DNA binding domain of the motility gene repressor (MogR) TACC_C PF05010.14 KOG96718.1 - 0.032 14.0 10.5 0.58 9.9 0.2 2.1 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal PEARLI-4 PF05278.12 KOG96718.1 - 0.12 11.9 6.3 0.19 11.3 6.3 1.3 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) ARD PF03079.14 KOG96718.1 - 0.14 12.3 4.9 0.23 11.6 4.9 1.3 1 0 0 1 1 1 0 ARD/ARD' family DUF641 PF04859.12 KOG96718.1 - 0.3 11.4 8.0 0.16 12.3 4.8 1.9 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Syntaxin_2 PF14523.6 KOG96718.1 - 0.47 10.8 8.7 1.3 9.5 8.7 1.7 1 1 0 1 1 1 0 Syntaxin-like protein VIT1 PF01988.19 KOG96718.1 - 8.1 6.2 5.2 12 5.7 4.6 1.4 1 1 0 1 1 1 0 VIT family Pkinase PF00069.25 KOG96719.1 - 9.1e-63 212.1 0.0 1.4e-62 211.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96719.1 - 1.6e-39 135.8 0.0 2.6e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG96719.1 - 1.8e-09 37.4 0.0 2.9e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KOG96719.1 - 0.00064 19.4 0.1 0.0015 18.2 0.1 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KOG96719.1 - 0.0029 17.5 0.1 0.022 14.7 0.2 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KOG96719.1 - 0.022 14.1 0.1 0.049 13.0 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L35Ae PF01247.18 KOG96720.1 - 7e-15 55.0 0.2 7.6e-15 54.9 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae DHFR_1 PF00186.19 KOG96721.1 - 3.1e-31 108.2 0.0 9.8e-31 106.6 0.0 1.7 1 1 1 2 2 2 1 Dihydrofolate reductase Oxysterol_BP PF01237.18 KOG96722.1 - 3.7e-58 197.2 7.7 6.8e-56 189.7 7.7 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein FAM60A PF15396.6 KOG96722.1 - 0.41 10.6 4.8 0.7 9.9 4.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A SPAN PF02510.14 KOG96723.1 - 0.25 10.5 0.0 20 4.3 0.0 2.1 2 0 0 2 2 2 0 Surface presentation of antigens protein Mur_ligase_M PF08245.12 KOG96724.1 - 1.4e-05 25.2 0.5 0.0033 17.5 0.4 3.1 1 1 1 2 2 2 2 Mur ligase middle domain Mur_ligase_C PF02875.21 KOG96724.1 - 9.1e-05 22.6 0.0 0.00024 21.3 0.0 1.7 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain TruD PF01142.18 KOG96726.1 - 1.4e-74 251.4 5.6 2.5e-70 237.4 0.3 3.2 1 1 1 2 2 2 2 tRNA pseudouridine synthase D (TruD) STN1_2 PF09170.10 KOG96726.1 - 0.11 12.7 3.9 0.27 11.4 3.9 1.6 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 MOZ_SAS PF01853.18 KOG96727.1 - 5.1e-83 277.1 0.5 7.7e-83 276.5 0.5 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 KOG96727.1 - 2.4e-21 75.1 0.5 6.7e-21 73.6 0.5 1.8 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 KOG96727.1 - 2.7e-21 75.2 0.6 5.5e-21 74.2 0.6 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 KOG96727.1 - 0.0018 18.6 0.0 0.0045 17.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOG96727.1 - 0.0031 17.7 0.0 0.017 15.3 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family HTH_Mga PF08280.11 KOG96727.1 - 0.017 15.1 1.6 0.044 13.8 1.6 1.6 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain DAGAT PF03982.13 KOG96728.1 - 2.4e-82 276.2 2.5 7.2e-73 245.1 0.0 2.0 1 1 1 2 2 2 2 Diacylglycerol acyltransferase adh_short PF00106.25 KOG96729.1 - 2.4e-23 82.6 0.0 1.1e-11 44.6 0.0 3.0 3 0 0 3 3 3 3 short chain dehydrogenase adh_short_C2 PF13561.6 KOG96729.1 - 2.2e-14 53.6 0.0 3.7e-09 36.5 0.0 3.0 3 0 0 3 3 3 3 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOG96729.1 - 0.01 15.8 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 KR domain DUF1776 PF08643.10 KOG96729.1 - 0.043 13.2 0.1 0.67 9.3 0.1 2.0 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) ANAPC5 PF12862.7 KOG96731.1 - 1.5e-29 101.9 4.8 6.9e-29 99.8 2.6 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_8 PF13181.6 KOG96731.1 - 0.09 13.0 0.5 34 5.0 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat CLP1_P PF16575.5 KOG96732.1 - 1.7e-32 112.8 0.0 2.3e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 KOG96732.1 - 9.6e-26 90.5 0.0 1.9e-25 89.6 0.0 1.5 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_N PF16573.5 KOG96732.1 - 3.3e-23 81.7 0.2 5.9e-23 80.9 0.2 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor AAA_16 PF13191.6 KOG96732.1 - 0.002 18.6 0.0 0.0028 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 KOG96732.1 - 0.0086 15.8 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 KOG96732.1 - 0.017 15.3 0.0 0.048 13.9 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 KOG96732.1 - 0.021 14.9 0.0 0.052 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOG96732.1 - 0.053 13.0 0.1 0.4 10.2 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 KOG96732.1 - 0.058 13.5 0.0 0.38 10.9 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase ABC_tran PF00005.27 KOG96732.1 - 0.072 13.6 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 KOG96732.1 - 0.085 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 KOG96732.1 - 0.14 12.2 0.0 0.29 11.2 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Rhodanese PF00581.20 KOG96733.1 - 2.4e-16 60.2 0.0 1.5e-08 35.1 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Tma16 PF11176.8 KOG96734.1 - 2e-46 157.5 3.3 2.4e-46 157.2 3.3 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 Acetyltransf_10 PF13673.7 KOG96735.1 - 9.5e-08 32.0 0.0 1.2e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOG96735.1 - 4.9e-07 30.0 0.0 6.1e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOG96735.1 - 2.4e-06 27.9 0.0 3.2e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Vps26 PF03643.15 KOG96735.1 - 0.0047 16.0 0.0 0.0056 15.7 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 DnaJ PF00226.31 KOG96736.1 - 5.2e-17 61.7 2.1 9.4e-17 60.9 0.3 2.5 2 1 0 2 2 2 1 DnaJ domain Sec63 PF02889.16 KOG96736.1 - 0.0059 15.8 0.0 0.053 12.7 0.0 2.3 2 1 0 2 2 2 1 Sec63 Brl domain DUF2232 PF09991.9 KOG96736.1 - 0.045 12.9 0.0 0.22 10.7 0.0 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) DUF5495 PF17599.2 KOG96736.1 - 0.095 13.0 0.5 1.4 9.3 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5495) TFR_dimer PF04253.15 KOG96738.1 - 2.2e-31 108.5 0.0 5.2e-31 107.3 0.0 1.7 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 KOG96738.1 - 0.0045 16.7 0.0 0.0091 15.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 KOG96738.1 - 0.053 13.5 0.0 0.23 11.5 0.0 2.2 1 1 0 1 1 1 0 PA domain EF-hand_7 PF13499.6 KOG96739.1 - 6.8e-27 93.7 9.5 9.8e-16 58.0 1.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOG96739.1 - 1.3e-23 80.7 14.7 3.4e-08 32.5 0.2 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOG96739.1 - 5.2e-19 66.5 12.1 5.1e-07 29.1 0.2 4.2 4 1 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 KOG96739.1 - 1.8e-16 59.7 10.9 1.1e-10 41.2 0.4 3.5 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOG96739.1 - 1.4e-13 49.6 6.9 5.2e-05 22.5 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 KOG96739.1 - 2.4e-09 37.4 0.5 0.00058 20.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOG96739.1 - 8.1e-07 29.0 1.4 0.0038 17.1 0.1 2.4 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOG96739.1 - 0.00069 19.9 0.8 0.3 11.4 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region PhetRS_B1 PF18262.1 KOG96739.1 - 0.016 15.5 1.0 0.07 13.4 0.3 2.2 2 0 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain Dockerin_1 PF00404.18 KOG96739.1 - 0.029 14.5 0.1 3.3 8.0 0.0 2.4 2 0 0 2 2 2 0 Dockerin type I domain EF-hand_14 PF17959.1 KOG96739.1 - 0.057 13.8 0.4 0.36 11.2 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain SurA_N_2 PF13623.6 KOG96739.1 - 0.065 13.1 0.1 1.7 8.5 0.0 2.3 2 0 0 2 2 2 0 SurA N-terminal domain MgtE_N PF03448.17 KOG96739.1 - 0.094 13.3 3.0 0.11 13.1 0.2 2.3 3 0 0 3 3 3 0 MgtE intracellular N domain DUF1296 PF06972.11 KOG96739.1 - 0.14 12.3 0.5 12 6.1 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1296) HTH_40 PF14493.6 KOG96739.1 - 0.17 12.4 0.4 1.4 9.4 0.1 2.2 1 1 1 2 2 2 0 Helix-turn-helix domain Caleosin PF05042.13 KOG96739.1 - 0.18 11.7 1.3 3.9 7.4 0.0 3.0 1 1 3 4 4 4 0 Caleosin related protein EF-hand_11 PF08976.11 KOG96739.1 - 0.18 12.7 0.2 0.75 10.7 0.1 1.9 1 1 1 2 2 2 0 EF-hand domain Staphylokinase PF02821.16 KOG96739.1 - 0.29 11.6 1.8 4.7 7.7 1.4 2.6 1 1 1 2 2 2 0 Staphylokinase/Streptokinase family HIT PF01230.23 KOG96740.1 - 3.3e-23 82.3 0.1 8.2e-23 81.0 0.0 1.6 2 0 0 2 2 2 1 HIT domain zf-C2HE PF16278.5 KOG96740.1 - 1e-16 61.1 2.8 2.4e-16 59.9 2.8 1.7 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger DcpS_C PF11969.8 KOG96740.1 - 2.2e-13 50.7 4.2 8.6e-13 48.8 1.6 2.4 2 1 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding zf-C2H2_4 PF13894.6 KOG96740.1 - 0.0038 17.9 1.3 0.019 15.8 1.3 2.3 1 0 0 1 1 1 1 C2H2-type zinc finger zf-BED PF02892.15 KOG96740.1 - 0.19 11.8 3.0 0.96 9.5 3.0 2.3 1 1 1 2 2 2 0 BED zinc finger Acyltransf_C PF16076.5 KOG96740.1 - 0.71 10.0 4.3 8.9 6.5 0.1 2.7 2 0 0 2 2 2 0 Acyltransferase C-terminus AAA PF00004.29 KOG96741.1 - 4.2e-42 143.7 0.0 8.2e-42 142.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG96741.1 - 1.1e-08 34.7 0.1 2.3e-08 33.7 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 KOG96741.1 - 5.1e-08 32.8 0.3 1.2e-07 31.5 0.3 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 KOG96741.1 - 1.2e-06 29.0 3.1 0.00019 21.8 0.0 3.2 2 2 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 KOG96741.1 - 1.2e-06 28.6 0.2 4.2e-05 23.6 0.2 2.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KOG96741.1 - 3.7e-05 23.9 0.0 8.4e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 KOG96741.1 - 6.6e-05 22.7 0.0 0.00014 21.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 KOG96741.1 - 0.00018 21.5 0.0 0.00033 20.7 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 KOG96741.1 - 0.0017 18.6 0.2 0.031 14.5 0.1 2.4 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.22 KOG96741.1 - 0.0023 18.3 0.0 0.005 17.2 0.0 1.6 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 KOG96741.1 - 0.0026 17.0 0.1 0.0049 16.1 0.1 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 KOG96741.1 - 0.0061 16.0 0.1 0.012 15.0 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KOG96741.1 - 0.0079 16.7 0.3 0.033 14.7 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOG96741.1 - 0.0095 16.1 0.0 0.023 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KOG96741.1 - 0.013 15.2 0.1 0.038 13.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 KOG96741.1 - 0.014 15.2 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Prot_ATP_OB_N PF17758.1 KOG96741.1 - 0.02 14.5 0.1 0.064 12.9 0.0 1.8 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain AAA_28 PF13521.6 KOG96741.1 - 0.026 14.8 0.5 0.067 13.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain Fib_alpha PF08702.10 KOG96741.1 - 0.044 14.0 2.8 0.1 12.8 2.8 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family AAA_7 PF12775.7 KOG96741.1 - 0.052 13.1 0.0 0.13 11.8 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 KOG96741.1 - 0.054 13.5 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KOG96741.1 - 0.056 12.9 0.1 0.11 11.9 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein ATPase PF06745.13 KOG96741.1 - 0.061 12.7 1.4 0.13 11.6 0.0 2.2 3 0 0 3 3 3 0 KaiC AAA_25 PF13481.6 KOG96741.1 - 0.064 12.8 0.1 0.19 11.3 0.1 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 KOG96741.1 - 0.071 12.2 0.1 0.16 11.0 0.1 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 KOG96741.1 - 0.077 12.8 4.1 0.94 9.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 KOG96741.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KOG96741.1 - 0.15 12.0 0.1 0.51 10.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain NTP_transf_3 PF12804.7 KOG96742.1 - 1.3e-05 25.6 0.0 2.3e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 KOG96742.1 - 0.00017 20.6 1.1 0.00077 18.5 0.6 2.0 1 1 1 2 2 2 2 L-fucokinase Hexapep PF00132.24 KOG96742.1 - 0.0045 16.6 3.1 0.31 10.8 0.6 3.3 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 KOG96742.1 - 0.0096 15.7 1.0 0.055 13.2 0.1 2.6 2 1 1 3 3 3 1 Hexapeptide repeat of succinyl-transferase CTP_transf_3 PF02348.19 KOG96742.1 - 0.011 15.7 0.1 0.058 13.3 0.0 2.1 2 0 0 2 2 2 0 Cytidylyltransferase DUF2547 PF10818.8 KOG96742.1 - 0.71 10.8 3.5 16 6.5 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2547) MitMem_reg PF13012.6 KOG96743.1 - 1.3e-34 118.9 1.3 2.3e-34 118.2 0.7 1.7 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 KOG96743.1 - 1.5e-32 112.0 0.0 3.1e-32 111.0 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease ATP_bind_1 PF03029.17 KOG96744.1 - 3.2e-83 279.2 0.0 4.9e-83 278.6 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 KOG96744.1 - 0.0013 19.3 0.7 0.28 11.7 0.1 2.7 2 1 0 2 2 2 1 AAA domain MeaB PF03308.16 KOG96744.1 - 0.036 13.1 0.1 0.11 11.5 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 KOG96744.1 - 0.048 13.9 0.0 0.11 12.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 KOG96744.1 - 0.055 13.9 3.2 0.3 11.5 0.1 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 KOG96744.1 - 0.08 13.0 0.1 1.5 8.9 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 KOG96744.1 - 0.11 12.9 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 KOG96744.1 - 0.14 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOG96744.1 - 0.18 12.2 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain TBCA PF02970.16 KOG96746.1 - 1.1e-26 93.0 9.7 1.3e-26 92.7 9.7 1.1 1 0 0 1 1 1 1 Tubulin binding cofactor A Cytochrom_C_2 PF01322.20 KOG96746.1 - 0.004 18.0 0.6 0.0046 17.8 0.6 1.0 1 0 0 1 1 1 1 Cytochrome C' PriA_3primeBD PF17764.1 KOG96746.1 - 0.11 12.5 0.2 0.24 11.3 0.1 1.7 1 1 1 2 2 2 0 3′ DNA-binding domain (3′BD) FapA PF03961.13 KOG96746.1 - 0.5 8.9 4.3 0.54 8.8 4.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Pkinase PF00069.25 KOG96748.1 - 3.2e-47 161.1 2.0 9.6e-44 149.7 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96748.1 - 2.1e-19 69.8 0.0 6.6e-19 68.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG96748.1 - 0.11 11.8 0.0 0.52 9.6 0.0 2.0 2 0 0 2 2 2 0 Kinase-like WD40 PF00400.32 KOG96750.1 - 2.2e-22 78.9 22.2 9.6e-06 26.3 0.5 7.6 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG96750.1 - 0.00019 21.7 1.1 0.77 10.1 0.6 3.6 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOG96750.1 - 0.00025 19.8 6.7 0.1 11.2 0.1 4.1 4 1 0 4 4 4 2 Nucleoporin Nup120/160 DivIC PF04977.15 KOG96750.1 - 0.023 14.5 0.1 0.047 13.5 0.1 1.5 1 0 0 1 1 1 0 Septum formation initiator PQQ_3 PF13570.6 KOG96750.1 - 0.047 14.2 0.0 0.58 10.7 0.0 2.7 2 0 0 2 2 2 0 PQQ-like domain MbeD_MobD PF04899.12 KOG96750.1 - 0.066 13.3 1.5 0.11 12.7 0.2 2.0 2 0 0 2 2 2 0 MbeD/MobD like bZIP_1 PF00170.21 KOG96750.1 - 0.16 12.1 0.1 0.27 11.4 0.1 1.3 1 0 0 1 1 1 0 bZIP transcription factor V_ATPase_I PF01496.19 KOG96751.1 - 0 1026.8 3.6 0 1026.6 3.6 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family PI_PP_I PF18363.1 KOG96751.1 - 0.018 15.2 1.4 0.038 14.2 0.3 2.1 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain GIT_CC PF16559.5 KOG96751.1 - 0.035 14.0 0.1 0.11 12.4 0.1 1.8 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF2096 PF09869.9 KOG96751.1 - 0.096 12.8 0.4 0.2 11.7 0.4 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) Mtc PF03820.17 KOG96752.1 - 1.7e-126 421.5 0.0 1.9e-126 421.4 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier WD40 PF00400.32 KOG96753.1 - 6.7e-27 93.2 16.6 1.6e-07 31.8 0.1 6.9 8 0 0 8 8 8 5 WD domain, G-beta repeat NLE PF08154.12 KOG96753.1 - 2.8e-24 85.4 0.1 5.4e-24 84.5 0.1 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 KOG96753.1 - 3.1e-09 36.0 4.5 0.00072 18.3 0.3 3.6 1 1 2 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 KOG96753.1 - 0.0047 17.2 0.1 0.049 13.9 0.0 2.7 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 KOG96753.1 - 0.053 12.2 2.7 1.8 7.3 0.5 3.4 3 1 0 3 3 3 0 Nup133 N terminal like WD40_like PF17005.5 KOG96753.1 - 0.073 12.4 2.5 1.7 7.9 0.6 2.9 2 1 0 2 2 2 0 WD40-like domain MFS_1 PF07690.16 KOG96754.1 - 1e-25 90.4 32.0 1e-25 90.4 32.0 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG96754.1 - 6.7e-06 25.2 0.0 0.00058 18.8 0.0 3.8 3 1 1 4 4 4 2 Sugar (and other) transporter DUF2207 PF09972.9 KOG96754.1 - 4.8 5.8 6.3 3 6.5 0.5 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) IPPT PF01715.17 KOG96755.1 - 3.7e-67 226.5 0.6 5.7e-67 225.9 0.6 1.2 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 KOG96755.1 - 1.8e-05 24.3 0.1 0.00014 21.4 0.0 2.3 2 0 0 2 2 2 1 Isopentenyl transferase AAA_18 PF13238.6 KOG96755.1 - 0.00045 20.8 2.5 0.0038 17.8 0.5 2.8 2 1 0 2 2 1 1 AAA domain AAA_33 PF13671.6 KOG96755.1 - 0.0005 20.2 0.0 0.0022 18.2 0.0 2.1 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KOG96755.1 - 0.0097 16.3 0.0 0.098 13.1 0.0 2.4 2 0 0 2 2 2 1 RNA helicase RsgA_GTPase PF03193.16 KOG96755.1 - 0.015 15.2 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase Zeta_toxin PF06414.12 KOG96755.1 - 0.037 13.3 0.2 0.14 11.4 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin TniB PF05621.11 KOG96755.1 - 0.073 12.5 0.0 2 7.8 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein Hpr_kinase_C PF07475.12 KOG96755.1 - 0.084 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_22 PF13401.6 KOG96755.1 - 0.12 12.7 0.0 0.94 9.7 0.0 2.3 3 0 0 3 3 3 0 AAA domain Cytidylate_kin PF02224.18 KOG96755.1 - 0.13 12.0 0.0 0.38 10.4 0.0 1.8 2 0 0 2 2 2 0 Cytidylate kinase IstB_IS21 PF01695.17 KOG96755.1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein zf-met PF12874.7 KOG96755.1 - 0.15 12.5 0.7 1.5 9.4 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Hydin_ADK PF17213.3 KOG96755.1 - 0.17 12.2 0.1 0.3 11.4 0.1 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF1062 PF06353.12 KOG96755.1 - 0.22 12.3 4.1 0.56 11.0 0.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1062) ParA PF10609.9 KOG96755.1 - 0.22 10.9 0.5 0.37 10.2 0.5 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase dNK PF01712.19 KOG96755.1 - 0.34 10.7 8.9 1.3 8.8 0.1 3.2 3 1 0 3 3 3 0 Deoxynucleoside kinase CbiA PF01656.23 KOG96755.1 - 0.76 9.8 2.7 0.61 10.1 0.4 2.0 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain BRO1 PF03097.18 KOG96756.1 - 4e-104 348.5 8.0 7.5e-104 347.6 8.0 1.5 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 KOG96756.1 - 5.9e-29 101.3 19.8 2e-27 96.3 15.6 2.7 2 1 0 2 2 2 1 ALIX V-shaped domain binding to HIV COX5A PF02284.16 KOG96756.1 - 0.04 13.9 0.6 5.7 7.0 0.1 3.3 3 0 0 3 3 3 0 Cytochrome c oxidase subunit Va NPV_P10 PF05531.12 KOG96756.1 - 7.8 7.0 8.4 4.1 8.0 2.0 3.7 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein CAF20 PF17052.5 KOG96757.1 - 9.1e-55 185.2 0.8 1e-54 185.0 0.8 1.0 1 0 0 1 1 1 1 Cap associated factor HEM4 PF02602.15 KOG96758.1 - 3.4e-45 154.2 0.0 3.9e-45 154.0 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD DUF5029 PF16432.5 KOG96758.1 - 0.016 14.8 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5029) Nucleo_P87 PF07267.11 KOG96759.1 - 0.29 9.9 4.7 0.44 9.4 4.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FSH1 PF03959.13 KOG96760.1 - 1.6e-67 227.2 0.0 2.1e-67 226.9 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S15 PF02129.18 KOG96760.1 - 0.002 17.8 0.0 0.004 16.8 0.0 1.5 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.16 KOG96760.1 - 0.015 15.1 0.0 0.037 13.8 0.0 1.7 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Phosducin PF02114.16 KOG96761.1 - 2.1e-08 33.4 2.8 0.00048 19.2 0.0 2.1 2 0 0 2 2 2 2 Phosducin RUN PF02759.19 KOG96761.1 - 0.066 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 RUN domain His_Phos_1 PF00300.22 KOG96762.1 - 4.5e-44 150.5 0.1 5.1e-44 150.3 0.1 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Rhodanese PF00581.20 KOG96764.1 - 4.3e-16 59.4 0.0 5.2e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Rhodanese PF00581.20 KOG96765.1 - 4.5e-10 40.0 0.0 5.5e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain RRP36 PF06102.12 KOG96766.1 - 6.3e-39 133.6 27.1 6.3e-39 133.6 27.1 2.3 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 Bacillus_HBL PF05791.11 KOG96766.1 - 0.093 12.5 10.6 0.064 13.1 3.7 2.4 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Thioredoxin PF00085.20 KOG96767.1 - 1.4e-25 89.2 0.3 7.8e-25 86.9 0.1 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.6 KOG96767.1 - 6.8e-05 22.8 0.4 0.049 13.5 0.0 3.3 1 1 2 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 KOG96767.1 - 0.00022 21.7 0.2 0.0012 19.3 0.1 2.2 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOG96767.1 - 0.00065 20.0 0.2 0.12 12.7 0.0 3.2 2 1 1 3 3 3 1 Thioredoxin-like OST3_OST6 PF04756.13 KOG96767.1 - 0.00071 19.0 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 KOG96767.1 - 0.0029 17.6 0.0 0.0064 16.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin domain TraF PF13728.6 KOG96767.1 - 0.0095 15.8 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 F plasmid transfer operon protein AhpC-TSA PF00578.21 KOG96767.1 - 0.043 13.7 0.0 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_7 PF13899.6 KOG96767.1 - 0.12 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like AMMECR1 PF01871.17 KOG96768.1 - 5.1e-37 127.0 0.0 6e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 SNF2_N PF00176.23 KOG96769.1 - 6.6e-72 242.1 0.3 1.8e-71 240.7 0.3 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOG96769.1 - 3.1e-22 79.0 0.8 6.4e-20 71.6 0.0 3.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SnAC PF14619.6 KOG96769.1 - 2.1e-15 57.1 3.5 2.1e-15 57.1 3.5 3.2 2 0 0 2 2 2 1 Snf2-ATP coupling, chromatin remodelling complex Bromodomain PF00439.25 KOG96769.1 - 1.5e-13 50.6 0.3 4.9e-13 48.9 0.3 1.9 1 0 0 1 1 1 1 Bromodomain QLQ PF08880.11 KOG96769.1 - 2e-09 37.0 0.5 2e-09 37.0 0.5 2.9 2 0 0 2 2 2 1 QLQ ResIII PF04851.15 KOG96769.1 - 1.7e-08 34.6 1.5 1.1e-07 32.1 0.0 3.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HSA PF07529.13 KOG96769.1 - 0.0002 21.6 11.0 0.0002 21.6 11.0 3.7 5 0 0 5 5 5 1 HSA P5-ATPase PF12409.8 KOG96770.1 - 4.2e-36 123.8 0.1 1.2e-35 122.3 0.1 1.9 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 KOG96770.1 - 7.2e-31 107.1 0.0 1.6e-30 106.0 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 KOG96770.1 - 1.2e-13 51.9 0.0 1.7e-06 28.5 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOG96770.1 - 2.6e-06 27.4 0.0 5.7e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KOG96770.1 - 0.016 14.9 0.0 7.1 6.3 0.0 2.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOG96770.1 - 0.026 14.2 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Mpv17_PMP22 PF04117.12 KOG96771.1 - 1.7e-16 60.2 0.8 1.7e-16 60.2 0.8 2.7 2 0 0 2 2 2 1 Mpv17 / PMP22 family Plug_translocon PF10559.9 KOG96771.1 - 0.025 14.4 0.7 0.1 12.5 0.1 2.3 2 0 0 2 2 2 0 Plug domain of Sec61p S10_plectin PF03501.15 KOG96772.1 - 3.1e-43 145.8 0.8 3.5e-43 145.6 0.8 1.0 1 0 0 1 1 1 1 Plectin/S10 domain DUF4364 PF14277.6 KOG96772.1 - 0.016 15.0 0.4 0.027 14.2 0.2 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4364) HTH_45 PF14947.6 KOG96772.1 - 0.06 13.3 0.7 0.089 12.8 0.3 1.5 2 0 0 2 2 2 0 Winged helix-turn-helix PadR PF03551.14 KOG96772.1 - 0.064 13.2 0.4 0.064 13.2 0.4 1.7 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family MsyB PF13984.6 KOG96772.1 - 0.092 13.1 0.0 0.12 12.7 0.0 1.2 1 0 0 1 1 1 0 MsyB protein RRS1 PF04939.12 KOG96773.1 - 1.1e-58 197.7 6.2 1.3e-58 197.5 6.2 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) SWIB PF02201.18 KOG96774.1 - 1.7e-26 91.9 0.6 4.8e-26 90.4 0.1 2.0 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.11 KOG96774.1 - 5.5e-05 23.0 1.7 0.00021 21.1 1.5 2.1 2 0 0 2 2 2 1 DEK C terminal domain FAM176 PF14851.6 KOG96774.1 - 1.8 8.2 8.2 0.16 11.7 2.7 1.9 2 0 0 2 2 2 0 FAM176 family PRP38_assoc PF12871.7 KOG96774.1 - 3.3 8.4 13.2 4.5 7.9 6.6 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term WRNPLPNID PF15017.6 KOG96774.1 - 3.8 8.5 13.6 1.9 9.4 7.6 2.4 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box Membr_traf_MHD PF10540.9 KOG96775.1 - 8.3e-41 139.6 0.3 3.1e-40 137.8 0.3 2.1 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 KOG96775.1 - 1.7e-11 44.3 0.0 7.6e-11 42.2 0.0 2.1 2 0 0 2 2 2 1 C2 domain DUF810 PF05664.11 KOG96775.1 - 0.00024 19.8 0.3 0.0029 16.2 0.1 2.3 2 0 0 2 2 2 1 Plant family of unknown function (DUF810) DUF4580 PF15162.6 KOG96775.1 - 0.027 14.1 0.1 0.065 12.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4580) DnaB_2 PF07261.11 KOG96775.1 - 0.031 14.0 0.0 1.3 8.9 0.0 2.9 2 0 0 2 2 2 0 Replication initiation and membrane attachment CybS PF05328.12 KOG96776.1 - 7.3e-47 158.4 0.0 9.3e-47 158.0 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Acyltransf_C PF16076.5 KOG96777.1 - 2.6e-06 27.4 0.4 9.3e-06 25.7 0.4 1.9 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.21 KOG96777.1 - 0.011 15.4 0.1 0.1 12.2 0.0 2.4 2 1 0 2 2 2 0 Acyltransferase MBF1 PF08523.10 KOG96778.1 - 1.6e-23 82.9 1.0 1.6e-23 82.9 1.0 2.6 3 1 0 3 3 3 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 KOG96778.1 - 6.2e-13 48.6 0.3 9.9e-13 47.9 0.3 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 KOG96778.1 - 0.00017 21.8 0.0 0.00035 20.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 KOG96778.1 - 0.011 15.7 0.2 0.021 14.9 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain ChAPs PF09295.10 KOG96779.1 - 4.7e-172 572.4 1.8 6e-172 572.1 1.8 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.6 KOG96779.1 - 0.0044 17.5 0.3 0.33 11.5 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOG96779.1 - 0.0097 16.0 1.6 0.82 9.9 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat Pox_A3L PF05288.11 KOG96779.1 - 0.099 12.6 0.4 2.4 8.2 0.3 2.6 2 0 0 2 2 2 0 Poxvirus A3L Protein ANAPC3 PF12895.7 KOG96779.1 - 0.16 12.2 4.1 1.4 9.2 0.8 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 RGS PF00615.19 KOG96780.1 - 4.2e-05 23.8 0.2 0.00075 19.8 0.0 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain Leader_CPA1 PF08252.11 KOG96781.1 - 2.3e-16 58.8 7.8 2.4e-16 58.8 7.8 1.0 1 0 0 1 1 1 1 arg-2/CPA1 leader peptide GATase PF00117.28 KOG96782.1 - 5.7e-49 166.5 0.0 8.1e-49 166.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 KOG96782.1 - 1.8e-44 150.6 0.0 2.9e-44 150.0 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 KOG96782.1 - 1.3e-05 25.0 0.3 0.00016 21.5 0.0 2.6 1 1 1 2 2 2 1 Peptidase C26 DJ-1_PfpI PF01965.24 KOG96782.1 - 0.0041 16.9 0.0 0.0084 15.9 0.0 1.5 1 1 0 1 1 1 1 DJ-1/PfpI family SNF2_N PF00176.23 KOG96783.1 - 2.3e-75 253.5 0.5 4.5e-75 252.6 0.5 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 KOG96783.1 - 6.4e-38 129.3 2.5 6.4e-38 129.3 2.5 3.7 3 0 0 3 3 3 1 SLIDE HAND PF09110.11 KOG96783.1 - 1e-36 126.1 6.3 1e-36 126.1 6.3 3.6 3 0 0 3 3 3 1 HAND Helicase_C PF00271.31 KOG96783.1 - 1.3e-21 77.0 0.0 1e-19 70.9 0.0 3.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG96783.1 - 4.8e-12 46.2 0.0 4.8e-12 46.2 0.0 3.5 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOG96783.1 - 0.00014 21.7 0.2 0.0004 20.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 KOG96783.1 - 0.0011 18.3 0.2 0.0026 17.0 0.2 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_14 PF13173.6 KOG96783.1 - 0.074 13.1 0.7 0.43 10.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain Gluconate_2-dh3 PF13618.6 KOG96783.1 - 0.074 13.3 0.9 0.52 10.6 0.1 2.5 2 0 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 DBINO PF13892.6 KOG96783.1 - 0.32 11.4 0.0 0.32 11.4 0.0 4.2 6 0 0 6 6 4 0 DNA-binding domain BAG PF02179.16 KOG96783.1 - 9.5 6.7 9.8 22 5.6 0.1 4.7 5 0 0 5 5 5 0 BAG domain DUF2524 PF10732.9 KOG96784.1 - 0.015 15.6 0.3 0.018 15.3 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2524) BLOC1_2 PF10046.9 KOG96784.1 - 0.024 14.9 2.0 0.031 14.6 2.0 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMCCDC2 PF15844.5 KOG96784.1 - 0.066 13.1 0.3 0.074 13.0 0.3 1.2 1 0 0 1 1 1 0 Transmembrane and coiled-coil domain-containing protein 2 DUF2034 PF10356.9 KOG96785.1 - 1.7e-64 216.7 0.2 2e-64 216.5 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 KOG96785.1 - 0.011 15.8 0.0 3.3 7.8 0.0 2.5 2 1 0 2 2 2 0 Restriction endonuclease Mrr_cat_2 PF13156.6 KOG96785.1 - 0.12 12.3 0.1 0.3 11.0 0.0 1.7 2 0 0 2 2 2 0 Restriction endonuclease MFS_1 PF07690.16 KOG96786.1 - 2e-32 112.5 48.2 1e-24 87.2 30.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG96786.1 - 7.3e-12 44.9 28.3 9e-08 31.4 8.2 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter MotB_plug PF13677.6 KOG96786.1 - 0.017 14.7 2.2 1 9.0 0.0 2.5 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB TPT PF03151.16 KOG96787.1 - 1.4e-31 109.9 24.2 6.7e-29 101.2 24.2 3.0 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOG96787.1 - 0.00078 19.6 29.7 0.029 14.5 7.5 4.0 3 1 1 4 4 4 4 EamA-like transporter family SART-1 PF03343.13 KOG96788.1 - 1.6e-52 179.0 49.0 1.6e-43 149.3 45.4 3.3 2 1 0 2 2 2 2 SART-1 family Nop PF01798.18 KOG96789.1 - 1.9e-81 272.9 0.3 1.9e-81 272.9 0.3 2.4 3 0 0 3 3 3 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 KOG96789.1 - 4e-19 68.8 1.7 4e-19 68.8 1.7 2.8 2 1 0 2 2 2 1 NOP5NT (NUC127) domain DUF4604 PF15377.6 KOG96789.1 - 0.052 14.0 42.8 0.097 13.1 42.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Aldolase PF01081.19 KOG96789.1 - 0.078 12.4 0.0 0.19 11.2 0.0 1.6 1 1 0 1 1 1 0 KDPG and KHG aldolase Ribosomal_L18A PF01775.17 KOG96791.1 - 4.9e-53 178.3 1.3 6.9e-53 177.9 1.3 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A RIG-I_C PF18119.1 KOG96792.1 - 0.046 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 RIG-I receptor C-terminal domain Cation_efflux PF01545.21 KOG96794.1 - 9.9e-55 185.4 5.3 1.3e-54 185.0 5.3 1.2 1 0 0 1 1 1 1 Cation efflux family AMP-binding PF00501.28 KOG96795.1 - 1.6e-89 300.4 0.0 2.4e-89 299.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOG96795.1 - 0.00049 21.0 0.0 0.0014 19.6 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RRM_1 PF00076.22 KOG96796.1 - 4.5e-28 96.9 1.7 4.6e-16 58.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOG96796.1 - 4.2e-06 26.4 0.5 0.00034 20.2 0.0 2.2 1 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KOG96796.1 - 0.0011 19.1 0.1 0.52 10.4 0.0 2.4 2 1 0 2 2 2 2 Limkain b1 Transposase_24 PF03004.14 KOG96796.1 - 0.0021 18.2 0.0 0.0061 16.7 0.0 1.6 1 1 1 2 2 2 1 Plant transposase (Ptta/En/Spm family) PHM7_cyt PF14703.6 KOG96796.1 - 0.017 15.3 0.1 0.1 12.8 0.0 2.1 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Glyco_transf_8 PF01501.20 KOG96797.1 - 0.0033 17.0 4.3 0.0052 16.4 3.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 KOG96797.1 - 0.014 14.7 1.8 0.021 14.2 1.5 1.6 1 1 0 1 1 1 0 Mannosyltransferase putative PMT PF02366.18 KOG96798.1 - 2.7e-96 321.9 21.1 5.6e-96 320.8 21.1 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 KOG96798.1 - 2.6e-53 180.6 12.6 2.6e-53 180.6 12.6 2.2 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 KOG96798.1 - 5.7e-24 85.0 0.0 9.1e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 MIR domain LDB19 PF13002.7 KOG96799.1 - 4.4e-100 333.2 1.0 6.8e-100 332.6 1.0 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 KOG96799.1 - 6.3e-06 26.3 0.3 1.7e-05 24.9 0.1 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Aldedh PF00171.22 KOG96800.1 - 1.8e-15 56.4 2.5 1e-10 40.8 0.2 2.3 1 1 0 2 2 2 2 Aldehyde dehydrogenase family URO-D PF01208.17 KOG96800.1 - 0.00079 18.7 0.0 0.0027 16.9 0.0 1.7 2 0 0 2 2 2 1 Uroporphyrinogen decarboxylase (URO-D) Hph PF13694.6 KOG96801.1 - 1.5e-48 165.5 8.7 1.5e-48 165.5 8.7 2.9 2 1 0 2 2 2 1 Sec63/Sec62 complex-interacting family FliJ PF02050.16 KOG96801.1 - 0.0086 16.3 0.8 0.031 14.5 0.3 2.2 1 1 0 1 1 1 1 Flagellar FliJ protein Med15_fungi PF05397.12 KOG96801.1 - 0.057 13.7 0.4 0.16 12.3 0.4 1.7 1 0 0 1 1 1 0 Mediator complex subunit 15 DUF1366 PF07104.11 KOG96801.1 - 2.9 7.6 5.5 0.33 10.7 0.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1366) DUF1664 PF07889.12 KOG96801.1 - 7.4 6.6 6.4 6 6.9 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Myosin_head PF00063.21 KOG96802.1 - 3.4e-284 944.3 16.2 3.4e-284 944.3 16.2 2.2 2 0 0 2 2 1 1 Myosin head (motor domain) DIL PF01843.19 KOG96802.1 - 4.6e-27 94.3 0.7 4.6e-27 94.3 0.7 3.4 3 1 0 3 3 3 1 DIL domain Myosin_N PF02736.19 KOG96802.1 - 6.8e-05 22.6 1.6 0.00013 21.7 0.6 2.1 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 KOG96802.1 - 0.0012 19.1 0.0 0.0012 19.1 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.6 KOG96802.1 - 0.057 13.8 0.4 0.29 11.5 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain IQ PF00612.27 KOG96802.1 - 0.19 11.6 21.5 0.26 11.2 0.0 6.1 7 0 0 7 7 7 0 IQ calmodulin-binding motif ABC_tran PF00005.27 KOG96802.1 - 0.27 11.7 0.0 0.27 11.7 0.0 3.3 2 1 0 2 2 1 0 ABC transporter Saccharop_dh_N PF04455.12 KOG96802.1 - 2.9 8.3 6.0 2.4 8.6 0.0 3.5 3 1 0 3 3 3 0 LOR/SDH bifunctional enzyme conserved region LMBR1 PF04791.16 KOG96802.1 - 7.5 5.3 15.5 20 3.9 15.5 1.7 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3987 PF13148.6 KOG96802.1 - 7.6 5.4 9.2 0.93 8.4 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) HSF_DNA-bind PF00447.17 KOG96802.1 - 8.2 7.1 7.2 0.94 10.1 0.2 3.1 3 0 0 3 3 3 0 HSF-type DNA-binding Synaptobrevin PF00957.21 KOG96803.1 - 8.4e-32 108.8 1.5 9.8e-32 108.6 1.5 1.0 1 0 0 1 1 1 1 Synaptobrevin Prominin PF05478.11 KOG96803.1 - 0.038 12.0 0.1 0.047 11.7 0.1 1.1 1 0 0 1 1 1 0 Prominin ABC2_membrane PF01061.24 KOG96804.1 - 3.5e-80 268.4 58.7 5.5e-42 143.6 24.0 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 KOG96804.1 - 1.3e-36 126.1 0.0 2.4e-17 63.7 0.0 3.0 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 KOG96804.1 - 1.6e-32 111.2 9.4 4.7e-30 103.3 0.1 3.5 3 0 0 3 3 3 2 CDR ABC transporter ABC_trans_N PF14510.6 KOG96804.1 - 3.6e-15 56.3 0.0 1e-14 54.9 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_25 PF13481.6 KOG96804.1 - 1.7e-07 31.0 0.0 2e-05 24.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOG96804.1 - 1.2e-05 25.8 0.1 0.00029 21.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 KOG96804.1 - 3.8e-05 23.6 0.2 0.013 15.3 0.0 2.8 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KOG96804.1 - 4.1e-05 24.2 0.1 0.022 15.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KOG96804.1 - 7e-05 22.5 0.2 0.0049 16.6 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.6 KOG96804.1 - 0.0001 22.4 0.0 0.0084 16.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KOG96804.1 - 0.00013 21.9 0.0 0.0029 17.5 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 KOG96804.1 - 0.00021 21.8 0.1 0.0035 17.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 KOG96804.1 - 0.0051 17.1 0.5 0.1 12.8 0.1 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 KOG96804.1 - 0.0055 16.3 0.7 0.74 9.4 0.1 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 KOG96804.1 - 0.0056 16.6 0.3 1.2 9.0 0.1 2.6 2 0 0 2 2 2 1 NACHT domain SMC_N PF02463.19 KOG96804.1 - 0.0058 16.1 0.0 0.57 9.6 0.0 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 KOG96804.1 - 0.0065 16.7 0.6 0.27 11.5 0.1 2.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOG96804.1 - 0.033 13.9 0.3 2.8 7.6 0.1 2.5 2 0 0 2 2 2 0 AAA domain DnaB_C PF03796.15 KOG96804.1 - 0.068 12.5 0.0 2.3 7.5 0.0 2.3 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_17 PF13207.6 KOG96804.1 - 0.15 12.5 0.1 1.7 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 KOG96804.1 - 0.17 12.0 0.3 11 6.1 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Glu-tRNAGln PF02686.15 KOG96805.1 - 0.019 15.2 0.0 0.052 13.8 0.0 1.7 1 0 0 1 1 1 0 Glu-tRNAGln amidotransferase C subunit PAD_porph PF04371.15 KOG96805.1 - 0.59 9.4 7.7 0.064 12.5 1.4 2.2 2 0 0 2 2 2 0 Porphyromonas-type peptidyl-arginine deiminase Tuberin PF03542.16 KOG96805.1 - 2.7 7.0 5.2 42 3.1 4.1 2.5 2 0 0 2 2 2 0 Tuberin DNApol_Exo PF18136.1 KOG96806.1 - 1.8e-98 329.1 0.2 7.2e-98 327.2 0.0 2.1 2 0 0 2 2 2 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 KOG96806.1 - 1.3e-57 195.6 0.0 2.4e-57 194.7 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A FtsH_ext PF06480.15 KOG96806.1 - 0.12 12.8 0.1 0.37 11.1 0.1 1.8 1 0 0 1 1 1 0 FtsH Extracellular vATP-synt_E PF01991.18 KOG96807.1 - 1.7e-68 229.9 12.4 2e-68 229.7 12.4 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Phlebovirus_NSM PF07246.11 KOG96807.1 - 0.031 13.7 7.2 0.044 13.2 7.2 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Folliculin PF11704.8 KOG96807.1 - 0.13 12.2 2.5 0.23 11.4 2.5 1.4 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Glyco_transf_24 PF18404.1 KOG96808.1 - 5.5e-34 117.8 0.6 9.7e-34 117.0 0.6 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 KOG96808.1 - 3.3e-18 66.6 2.1 1e-16 61.7 0.4 3.6 1 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 KOG96808.1 - 1.5e-10 41.1 2.3 6.1e-10 39.2 2.3 2.0 1 0 0 1 1 1 1 Thioredoxin-like domain Fungal_trans PF04082.18 KOG96809.1 - 2.5e-38 131.6 5.7 5.5e-38 130.5 3.2 2.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG96809.1 - 6.3e-08 32.6 8.5 1.1e-07 31.9 8.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SWIRM PF04433.17 KOG96810.1 - 6.8e-08 32.7 0.0 1.6e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain UQ_con PF00179.26 KOG96811.1 - 1.1e-49 167.7 0.1 1.2e-49 167.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOG96811.1 - 0.0014 18.9 0.1 0.0019 18.5 0.1 1.4 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 KOG96811.1 - 0.0032 17.3 0.5 0.0059 16.4 0.5 1.4 1 1 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 KOG96811.1 - 0.008 15.9 0.0 0.0096 15.6 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RPA43_OB PF17875.1 KOG96812.1 - 7.3e-32 110.6 0.1 7.3e-32 110.6 0.1 1.7 2 0 0 2 2 2 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 KOG96812.1 - 2.1e-13 50.4 0.0 4.1e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rpb1_5 PF04998.17 KOG96813.1 - 5.9e-100 334.1 6.0 6.1e-98 327.5 1.8 3.4 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 KOG96813.1 - 9.2e-71 237.4 0.3 2.2e-70 236.2 0.3 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 KOG96813.1 - 1.7e-39 135.3 0.0 1.8e-38 132.0 0.0 2.9 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 KOG96813.1 - 5.9e-26 91.5 0.3 5.9e-26 91.5 0.3 3.5 4 0 0 4 4 4 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 KOG96813.1 - 1.1e-23 83.2 2.9 2.4e-23 82.1 0.0 3.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 Syntaxin_2 PF14523.6 KOG96813.1 - 0.43 11.0 6.7 1.1 9.6 1.1 3.3 2 0 0 2 2 2 0 Syntaxin-like protein Connexin PF00029.19 KOG96813.1 - 7.3 6.3 6.8 1.8 8.3 0.1 2.5 2 0 0 2 2 2 0 Connexin HLH PF00010.26 KOG96815.1 - 6.1e-21 74.1 0.6 1.4e-20 73.0 0.1 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUP PF00674.18 KOG96816.1 - 1.9e-29 101.8 3.1 4.2e-29 100.7 3.1 1.6 1 1 0 1 1 1 1 DUP family Clathrin PF00637.20 KOG96816.1 - 0.077 12.9 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Region in Clathrin and VPS IMS PF00817.20 KOG96817.1 - 2.8e-29 102.1 0.0 6.2e-29 100.9 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family BRCT_2 PF16589.5 KOG96817.1 - 3.8e-14 52.9 0.0 1e-13 51.4 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 KOG96817.1 - 4.3e-11 43.0 3.9 3.6e-10 40.1 0.1 3.7 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain IMS_C PF11799.8 KOG96817.1 - 7.1e-10 39.6 0.0 3.7e-09 37.3 0.0 2.1 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain LIG3_BRCT PF16759.5 KOG96817.1 - 3.4e-06 27.3 0.0 7.8e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain REV1_C PF16727.5 KOG96817.1 - 1.4e-05 25.4 0.0 2.9e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain PTCB-BRCT PF12738.7 KOG96817.1 - 2.7e-05 24.0 0.1 9.9e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 twin BRCT domain mCpol PF18182.1 KOG96817.1 - 0.1 12.9 0.0 0.59 10.5 0.0 2.3 2 0 0 2 2 2 0 minimal CRISPR polymerase domain PK PF00224.21 KOG96818.1 - 3.6e-157 522.7 0.4 4.7e-157 522.3 0.4 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KOG96818.1 - 2.6e-31 108.3 0.0 5.6e-31 107.2 0.0 1.6 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 KOG96818.1 - 0.0043 16.2 0.3 0.015 14.4 0.1 1.8 1 1 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family AA_permease PF00324.21 KOG96819.1 - 1.9e-150 501.7 37.5 2.1e-150 501.5 37.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG96819.1 - 1.1e-23 83.8 41.1 1.4e-23 83.5 41.1 1.1 1 0 0 1 1 1 1 Amino acid permease MNE1 PF13762.6 KOG96822.1 - 2.8e-32 111.8 7.0 2.8e-32 111.8 7.0 2.2 2 0 0 2 2 2 1 Mitochondrial splicing apparatus component DUF4476 PF14771.6 KOG96822.1 - 0.15 12.4 1.9 0.74 10.2 1.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4476) Pkinase PF00069.25 KOG96823.1 - 5e-54 183.4 0.0 9.8e-54 182.5 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96823.1 - 6.5e-30 104.3 0.0 1e-29 103.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 KOG96823.1 - 8.6e-16 58.1 0.1 2.6e-15 56.5 0.0 1.9 2 0 0 2 2 2 1 FHA domain Pkinase_fungal PF17667.1 KOG96823.1 - 5.3e-07 28.8 0.0 1e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOG96823.1 - 0.00022 20.7 0.0 0.00034 20.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOG96823.1 - 0.0032 16.8 0.1 0.0081 15.5 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOG96823.1 - 0.15 12.0 0.1 1.1 9.1 0.2 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF3240 PF11582.8 KOG96823.1 - 0.15 12.2 0.0 15 5.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3240) TFB6 PF17110.5 KOG96824.1 - 2.1e-29 102.5 0.0 2.1e-28 99.2 0.0 2.2 1 1 1 2 2 2 1 Subunit 11 of the general transcription factor TFIIH SOG2 PF10428.9 KOG96825.1 - 1.4e-146 489.6 17.7 1.4e-146 489.6 17.7 2.0 2 1 0 2 2 2 1 RAM signalling pathway protein LRR_8 PF13855.6 KOG96825.1 - 3.4e-21 74.8 25.3 2.1e-11 43.4 2.8 3.2 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 KOG96825.1 - 1e-13 51.2 15.6 9.8e-08 32.2 0.5 4.4 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KOG96825.1 - 0.0003 20.3 1.4 0.0003 20.3 1.4 2.2 2 0 0 2 2 2 1 Leucine-rich repeat SpecificRecomb PF10136.9 KOG96825.1 - 0.012 14.0 0.7 0.024 13.0 0.7 1.4 1 0 0 1 1 1 0 Site-specific recombinase LRR_1 PF00560.33 KOG96825.1 - 0.02 15.4 9.3 28 5.8 0.0 5.7 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 KOG96825.1 - 0.033 14.2 10.3 3.9 7.8 0.0 5.9 5 0 0 5 5 5 0 Leucine Rich repeat Syntaxin_2 PF14523.6 KOG96825.1 - 0.15 12.4 9.9 1 9.8 0.1 4.1 3 0 0 3 3 3 0 Syntaxin-like protein PRD PF00874.20 KOG96825.1 - 0.23 11.8 3.9 2.2 8.6 0.7 3.4 3 1 0 3 3 3 0 PRD domain ApoLp-III PF07464.11 KOG96826.1 - 0.0015 18.6 0.6 0.0055 16.8 0.6 2.0 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) Homez PF11569.8 KOG96826.1 - 0.0059 16.1 0.0 0.032 13.7 0.0 2.2 2 0 0 2 2 2 1 Homeodomain leucine-zipper encoding, Homez BST2 PF16716.5 KOG96826.1 - 0.033 14.8 0.4 0.098 13.2 0.4 1.8 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 ETF_QO PF05187.13 KOG96828.1 - 3.4e-45 152.4 0.1 6.1e-45 151.6 0.1 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 KOG96828.1 - 1.5e-09 37.9 0.1 5.6e-05 22.9 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOG96828.1 - 7.4e-09 35.2 2.7 0.0025 16.9 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 KOG96828.1 - 8.5e-07 28.4 0.0 0.0016 17.7 0.0 2.2 2 0 0 2 2 2 2 Thi4 family NAD_binding_8 PF13450.6 KOG96828.1 - 3.5e-06 27.1 0.1 9.3e-06 25.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 KOG96828.1 - 5.9e-06 25.9 0.2 8.4e-06 25.4 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOG96828.1 - 6.6e-05 22.3 0.3 0.00032 20.0 0.1 1.9 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOG96828.1 - 0.0074 15.0 0.6 0.027 13.2 0.6 1.8 2 0 0 2 2 2 1 HI0933-like protein Fer4_7 PF12838.7 KOG96828.1 - 0.0078 16.8 0.5 0.021 15.4 0.5 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Pyr_redox_3 PF13738.6 KOG96828.1 - 0.0085 15.4 0.4 0.015 14.6 0.4 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOG96828.1 - 0.023 13.9 0.2 0.046 13.0 0.2 1.5 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 KOG96828.1 - 0.058 13.4 0.2 0.11 12.5 0.2 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 KOG96828.1 - 0.09 11.8 0.4 0.12 11.3 0.4 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.27 KOG96828.1 - 0.11 13.1 1.4 12 6.5 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fer4_2 PF12797.7 KOG96828.1 - 0.19 11.9 0.5 0.48 10.6 0.5 1.6 1 0 0 1 1 1 0 4Fe-4S binding domain Trp_halogenase PF04820.14 KOG96828.1 - 0.31 9.8 0.4 2.4 6.9 0.3 2.2 2 0 0 2 2 2 0 Tryptophan halogenase PX PF00787.24 KOG96829.1 - 1.6e-23 82.8 0.1 2e-23 82.5 0.1 1.1 1 0 0 1 1 1 1 PX domain Histone PF00125.24 KOG96830.1 - 1.3e-27 96.8 0.0 2.1e-27 96.1 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOG96830.1 - 1.5e-19 70.1 2.1 2.4e-19 69.4 2.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-X PF09415.10 KOG96830.1 - 0.19 12.0 2.0 0.22 11.9 0.3 1.9 2 0 0 2 2 2 0 CENP-S associating Centromere protein X SAM_2 PF07647.17 KOG96831.1 - 1.3e-08 34.8 0.2 3.7e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KOG96831.1 - 0.022 15.2 0.1 0.053 14.0 0.1 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PDEase_I PF00233.19 KOG96832.1 - 1.5e-50 172.2 2.7 2.3e-50 171.5 2.7 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 KOG96832.1 - 0.012 15.9 0.1 0.041 14.1 0.0 2.0 2 0 0 2 2 2 0 HD domain DNA_ligase_IV PF11411.8 KOG96832.1 - 0.13 12.4 0.2 0.48 10.6 0.2 2.0 1 0 0 1 1 1 0 DNA ligase IV eIF2A PF08662.11 KOG96833.1 - 1.3e-27 96.9 1.9 7.2e-24 84.7 0.4 3.5 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 KOG96833.1 - 1.2e-08 34.6 0.1 2.7e-08 33.5 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Coatomer_WDAD PF04053.14 KOG96833.1 - 0.024 13.7 0.3 0.41 9.6 0.0 2.7 3 1 0 3 3 3 0 Coatomer WD associated region Seryl_tRNA_N PF02403.22 KOG96833.1 - 1.7 8.9 5.8 3.1 8.1 5.8 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Proteasome PF00227.26 KOG96834.1 - 3e-52 176.9 0.0 4.1e-52 176.4 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOG96834.1 - 4.3e-12 45.5 1.0 6.2e-12 45.0 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF2457 PF10446.9 KOG96834.1 - 9.3 5.3 10.4 12 4.9 10.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) MFS_1 PF07690.16 KOG96835.1 - 2.7e-36 125.2 34.6 2.7e-36 125.2 34.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 KOG96835.1 - 0.00011 20.8 4.0 0.0002 20.0 4.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Zn_clus PF00172.18 KOG96836.1 - 3.3e-10 39.9 10.2 8.1e-10 38.7 10.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TRP PF06011.12 KOG96837.1 - 3.7e-128 427.9 36.3 4.6e-128 427.6 36.3 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 KOG96837.1 - 2.9e-36 124.9 0.8 5.2e-36 124.1 0.8 1.5 1 0 0 1 1 1 1 ML-like domain CH PF00307.31 KOG96838.1 - 3.2e-16 59.5 0.0 4.5e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.11 KOG96838.1 - 0.007 16.6 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 CDC24 Calponin PsaL PF02605.15 KOG96838.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit XI Rad1 PF02144.16 KOG96839.1 - 4.4e-70 235.9 2.8 5.5e-70 235.6 2.8 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 GHD PF17834.1 KOG96839.1 - 0.0049 16.9 0.0 0.018 15.1 0.0 1.9 2 0 0 2 2 2 1 Beta-sandwich domain in beta galactosidase ATP-grasp PF02222.22 KOG96839.1 - 0.11 12.1 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp domain Ribosomal_L7Ae PF01248.26 KOG96840.1 - 1.6e-22 79.0 0.3 2e-22 78.7 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family GDI PF00996.18 KOG96841.1 - 6.9e-47 159.9 0.0 1.7e-46 158.6 0.0 1.6 1 1 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 KOG96841.1 - 0.036 14.3 0.0 0.08 13.2 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain UDPG_MGDP_dh_N PF03721.14 KOG96841.1 - 0.14 11.7 0.1 0.3 10.7 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 KOG96841.1 - 0.22 10.7 0.0 0.61 9.3 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain Kelch_5 PF13854.6 KOG96842.1 - 8.1e-09 35.3 0.2 0.37 10.8 0.0 5.0 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 KOG96842.1 - 2.8e-07 30.4 5.1 0.0098 15.9 0.1 4.9 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KOG96842.1 - 3.1e-06 26.6 7.2 1.3 8.6 1.5 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 KOG96842.1 - 1.5e-05 24.8 5.6 0.69 10.0 0.0 5.4 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 KOG96842.1 - 2.8e-05 24.3 1.8 0.53 10.6 0.1 5.0 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 KOG96842.1 - 0.00013 22.1 0.7 0.027 14.8 0.0 4.6 5 0 0 5 5 5 1 Galactose oxidase, central domain LRR_4 PF12799.7 KOG96844.1 - 1.1e-14 54.3 44.5 6.9e-07 29.5 1.3 7.5 6 2 2 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOG96844.1 - 6.3e-12 45.1 36.0 7.1e-06 25.7 0.5 7.0 3 2 3 8 8 8 5 Leucine rich repeat LRR_9 PF14580.6 KOG96844.1 - 9.2e-10 38.3 9.9 0.028 13.9 0.4 4.3 2 1 2 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 KOG96844.1 - 1.3e-06 28.0 24.7 0.72 10.1 0.1 9.0 9 0 0 9 9 9 4 Leucine Rich repeat LRR_1 PF00560.33 KOG96844.1 - 0.51 11.1 31.0 7.1 7.6 0.0 9.2 9 1 0 9 9 9 0 Leucine Rich Repeat PRP1_N PF06424.12 KOG96844.1 - 1 9.7 8.6 5.6 7.4 0.1 2.7 1 1 1 2 2 2 0 PRP1 splicing factor, N-terminal Aldedh PF00171.22 KOG96845.1 - 9.1e-183 608.0 0.2 1e-182 607.8 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 KOG96845.1 - 0.0014 18.1 0.1 0.52 9.7 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) LuxC PF05893.14 KOG96845.1 - 0.0077 15.3 0.0 0.017 14.2 0.0 1.6 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) ELFV_dehydrog PF00208.21 KOG96846.1 - 2.7e-84 282.7 3.6 3.3e-84 282.4 3.6 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 KOG96846.1 - 5.8e-48 162.1 0.0 1.3e-47 160.9 0.0 1.6 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.6 KOG96846.1 - 0.18 12.3 0.4 0.38 11.2 0.1 1.6 2 0 0 2 2 2 0 Putative NAD(P)-binding AATase PF07247.12 KOG96847.1 - 3.5e-215 715.3 0.0 4e-215 715.1 0.0 1.0 1 0 0 1 1 1 1 Alcohol acetyltransferase MFS_1 PF07690.16 KOG96848.1 - 2e-45 155.3 49.2 8.8e-45 153.1 49.2 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG96848.1 - 0.053 12.4 29.7 0.25 10.1 11.8 2.4 2 0 0 2 2 2 0 Sugar (and other) transporter Fungal_trans PF04082.18 KOG96849.1 - 1.2e-13 50.7 0.1 1.6e-13 50.3 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG96849.1 - 3.7e-08 33.3 7.5 6.5e-08 32.6 7.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_8 PF08022.12 KOG96850.1 - 1.4e-28 99.1 0.0 2.5e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 KOG96850.1 - 2.2e-28 99.4 0.0 3.4e-28 98.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 KOG96850.1 - 6.9e-25 87.6 13.3 6.9e-25 87.6 13.3 2.9 3 0 0 3 3 3 1 Ferric reductase like transmembrane component COX7B PF05392.11 KOG96850.1 - 0.051 13.2 0.6 0.17 11.6 0.6 1.8 1 0 0 1 1 1 0 Cytochrome C oxidase chain VIIB PRESAN PF09687.10 KOG96850.1 - 0.24 12.0 1.5 0.75 10.4 0.5 2.0 2 0 0 2 2 2 0 Plasmodium RESA N-terminal Sugar_tr PF00083.24 KOG96851.1 - 1.1e-79 268.4 28.2 1.3e-79 268.2 28.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG96851.1 - 8.1e-23 80.9 36.0 5.2e-12 45.4 18.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DMT_YdcZ PF04657.13 KOG96851.1 - 0.005 17.1 0.5 0.005 17.1 0.5 3.6 3 1 0 3 3 3 1 Putative inner membrane exporter, YdcZ BT1 PF03092.16 KOG96851.1 - 0.0067 14.7 0.2 0.0067 14.7 0.2 2.6 3 0 0 3 3 3 2 BT1 family MFS_3 PF05977.13 KOG96851.1 - 0.039 12.3 1.6 0.082 11.3 0.6 1.9 2 0 0 2 2 2 0 Transmembrane secretion effector Aldo_ket_red PF00248.21 KOG96852.1 - 6.9e-73 245.4 0.0 7.9e-73 245.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Hist_deacetyl PF00850.19 KOG96853.1 - 2.5e-82 276.8 0.0 3.9e-82 276.2 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain AAA PF00004.29 KOG96854.1 - 4.4e-59 198.7 0.0 1.8e-45 154.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG96854.1 - 4.4e-08 32.8 0.0 9.8e-06 25.3 0.0 2.6 2 0 0 2 2 2 1 AAA+ lid domain AAA_2 PF07724.14 KOG96854.1 - 2.7e-05 24.4 0.0 0.00031 20.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KOG96854.1 - 0.00031 21.2 0.1 0.042 14.2 0.0 2.7 1 1 1 2 2 2 1 AAA ATPase domain Parvo_NS1 PF01057.17 KOG96854.1 - 0.00037 19.7 0.0 0.00075 18.7 0.0 1.4 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 RuvB_N PF05496.12 KOG96854.1 - 0.00037 20.3 0.0 0.00085 19.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 KOG96854.1 - 0.0028 18.0 0.0 0.014 15.8 0.0 2.3 1 0 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 KOG96854.1 - 0.0046 16.5 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 KOG96854.1 - 0.0048 16.9 0.0 0.021 14.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KOG96854.1 - 0.0084 16.7 0.5 0.19 12.3 0.0 3.0 3 1 0 3 3 3 1 AAA domain AAA_22 PF13401.6 KOG96854.1 - 0.012 15.9 0.1 0.099 12.9 0.0 2.5 2 1 1 3 3 2 0 AAA domain Vps4_C PF09336.10 KOG96854.1 - 0.013 15.4 0.5 0.052 13.6 0.1 2.3 2 0 0 2 2 1 0 Vps4 C terminal oligomerisation domain TIP49 PF06068.13 KOG96854.1 - 0.014 14.7 0.0 0.032 13.5 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase PF06745.13 KOG96854.1 - 0.015 14.6 0.0 0.035 13.5 0.0 1.5 1 0 0 1 1 1 0 KaiC IstB_IS21 PF01695.17 KOG96854.1 - 0.017 14.9 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 KOG96854.1 - 0.027 13.8 0.1 0.057 12.8 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 KOG96854.1 - 0.043 13.8 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KOG96854.1 - 0.091 12.3 0.1 0.58 9.7 0.0 1.9 1 1 1 2 2 2 0 AAA domain TsaE PF02367.17 KOG96854.1 - 0.15 12.1 0.0 0.44 10.6 0.0 1.8 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DnaJ PF00226.31 KOG96855.1 - 0.00046 20.3 0.1 0.00093 19.3 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 KOG96855.1 - 0.014 15.4 0.1 0.019 15.0 0.1 1.3 1 0 0 1 1 1 0 Pam16 Osmo_CC PF08946.10 KOG96855.1 - 0.059 13.6 4.4 3.8 7.8 0.6 2.5 2 0 0 2 2 2 0 Osmosensory transporter coiled coil DHHC PF01529.20 KOG96857.1 - 8.1e-32 110.1 14.9 8.1e-32 110.1 14.9 2.3 2 1 0 2 2 2 1 DHHC palmitoyltransferase PsbN PF02468.15 KOG96857.1 - 2.6 7.9 7.5 0.56 10.1 3.1 2.1 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) Syja_N PF02383.18 KOG96858.1 - 3.2e-75 253.4 1.2 3.9e-75 253.1 0.1 1.7 2 0 0 2 2 2 1 SacI homology domain CDC50 PF03381.15 KOG96859.1 - 1.1e-80 271.1 1.1 1.5e-80 270.7 1.1 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family KRE1 PF17056.5 KOG96860.1 - 4e-26 90.5 8.7 4e-26 90.5 8.7 5.3 3 2 4 7 7 7 1 Killer toxin-resistance protein 1 Adhesin_P1_N PF18652.1 KOG96860.1 - 0.97 9.5 9.7 18 5.5 1.8 3.6 2 1 1 3 3 3 0 Adhesin P1 N-terminal domain Macoilin PF09726.9 KOG96860.1 - 5.7 5.4 5.9 7.2 5.0 5.9 1.2 1 0 0 1 1 1 0 Macoilin family Na_Ca_ex PF01699.24 KOG96861.1 - 4.4e-20 72.2 29.0 3.2e-16 59.6 11.9 3.1 4 0 0 4 4 4 2 Sodium/calcium exchanger protein YccF PF03733.13 KOG96861.1 - 2.4e-12 47.4 5.7 2.4e-12 47.4 5.7 4.6 5 0 0 5 5 5 1 Inner membrane component domain Hydrolase_4 PF12146.8 KOG96862.1 - 8.7e-15 54.6 0.0 8.9e-09 35.0 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOG96862.1 - 1.4e-08 34.7 0.0 6.8e-05 22.6 0.1 2.4 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOG96862.1 - 0.0001 21.8 0.0 0.0008 18.9 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 KOG96862.1 - 0.0019 17.9 0.0 0.0029 17.3 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) BAAT_C PF08840.11 KOG96862.1 - 0.0053 16.7 0.0 0.11 12.4 0.0 2.1 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.7 KOG96862.1 - 0.035 14.7 0.0 0.044 14.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Sugar_tr PF00083.24 KOG96863.1 - 1.2e-114 383.6 33.5 1.5e-114 383.4 33.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG96863.1 - 1.1e-26 93.6 24.9 7.9e-23 80.9 18.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 KOG96863.1 - 3.8 5.7 24.5 2 6.6 17.3 3.0 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family WD40 PF00400.32 KOG96864.1 - 1.5e-30 104.8 11.5 1.2e-06 29.1 0.1 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG96864.1 - 8.2e-18 64.5 0.2 0.024 15.0 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOG96864.1 - 1.4e-05 25.1 1.6 0.11 12.3 0.1 3.3 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOG96864.1 - 0.00027 20.0 1.5 3.2 6.6 0.0 4.2 1 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PDT PF00800.18 KOG96865.1 - 2.6e-57 193.6 0.2 3.2e-57 193.3 0.2 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ATP11 PF06644.11 KOG96866.1 - 1.9e-96 323.0 2.5 2.2e-96 322.8 2.5 1.0 1 0 0 1 1 1 1 ATP11 protein zf-C2HE PF16278.5 KOG96866.1 - 0.28 11.6 0.2 0.28 11.6 0.2 2.3 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Myb_DNA-bind_5 PF13873.6 KOG96867.1 - 0.00057 19.9 0.8 0.001 19.1 0.1 1.8 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.7 KOG96867.1 - 0.11 13.5 0.5 0.23 12.5 0.1 1.8 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF573 PF04504.14 KOG96867.1 - 0.12 13.1 0.6 0.35 11.6 0.6 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF573 Occludin_ELL PF07303.13 KOG96867.1 - 0.16 12.7 2.0 0.62 10.8 0.0 2.5 2 1 1 3 3 3 0 Occludin homology domain TPR_8 PF13181.6 KOG96868.1 - 8.5e-09 35.0 5.1 0.0018 18.3 0.0 5.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOG96868.1 - 6.3e-08 32.1 1.8 0.01 15.9 0.2 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOG96868.1 - 3.7e-07 29.7 1.4 0.29 11.0 0.1 5.6 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOG96868.1 - 6.2e-06 26.6 5.6 0.016 15.7 0.0 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOG96868.1 - 2.6e-05 24.7 2.0 7.6 7.6 0.0 5.9 4 2 2 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOG96868.1 - 0.0036 17.4 0.4 0.025 14.7 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOG96868.1 - 0.0057 16.9 2.6 1.5 9.1 0.1 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOG96868.1 - 0.019 15.6 0.9 0.73 10.5 0.0 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_15 PF13429.6 KOG96868.1 - 0.022 14.0 1.1 0.91 8.7 0.5 2.7 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOG96868.1 - 0.03 14.0 0.0 0.36 10.5 0.0 2.9 3 1 1 4 4 4 0 TPR repeat TPR_17 PF13431.6 KOG96868.1 - 0.049 14.0 2.7 0.57 10.7 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOG96868.1 - 0.16 12.2 2.5 6.9 7.0 0.9 3.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KOG96868.1 - 0.23 11.6 4.9 19 5.6 0.0 5.1 7 0 0 7 7 6 0 Tetratricopeptide repeat ChAPs PF09295.10 KOG96868.1 - 0.79 8.7 3.3 0.74 8.7 0.3 2.4 2 1 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) PPR PF01535.20 KOG96868.1 - 3.3 8.2 4.6 3.1 8.3 0.1 3.3 4 0 0 4 4 4 0 PPR repeat tRNA_anti-codon PF01336.25 KOG96869.1 - 1.1e-10 41.4 0.3 1.9e-10 40.6 0.3 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RPA_C PF08784.11 KOG96869.1 - 1.2e-06 29.1 0.0 7.4e-06 26.6 0.0 2.1 1 1 1 2 2 2 1 Replication protein A C terminal HTH_IclR PF09339.10 KOG96869.1 - 0.029 14.2 0.0 0.051 13.4 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain CDC24_OB3 PF17244.2 KOG96869.1 - 0.052 13.3 0.3 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 3 F-box-like PF12937.7 KOG96870.1 - 4.1e-06 26.6 0.9 1e-05 25.3 0.2 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 KOG96870.1 - 1.2e-05 25.1 0.5 1.2e-05 25.1 0.5 2.3 2 0 0 2 2 2 1 F-box domain HAD_2 PF13419.6 KOG96870.1 - 0.019 15.0 1.0 0.26 11.3 0.0 3.1 4 0 0 4 4 4 0 Haloacid dehalogenase-like hydrolase zf-DNL PF05180.12 KOG96871.1 - 5.2e-29 100.0 3.9 8.1e-29 99.4 3.9 1.3 1 0 0 1 1 1 1 DNL zinc finger zinc_ribbon_4 PF13717.6 KOG96871.1 - 0.0041 17.0 1.5 0.56 10.2 0.0 2.5 2 0 0 2 2 2 2 zinc-ribbon domain Elf1 PF05129.13 KOG96871.1 - 0.016 15.2 1.4 0.024 14.7 1.4 1.3 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like HypA PF01155.19 KOG96871.1 - 0.018 15.1 0.1 0.024 14.6 0.1 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3113 PF11310.8 KOG96871.1 - 0.053 13.5 0.2 1.1 9.3 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3113) zinc_ribbon_10 PF10058.9 KOG96871.1 - 0.074 12.8 1.0 0.14 11.9 1.0 1.5 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-ZPR1 PF03367.13 KOG96871.1 - 0.35 10.7 4.1 0.81 9.5 3.2 2.0 1 1 1 2 2 2 0 ZPR1 zinc-finger domain Zn_Tnp_IS1595 PF12760.7 KOG96871.1 - 1.6 8.8 5.8 3.7 7.6 0.6 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain Kri1_C PF12936.7 KOG96873.1 - 7.1e-30 103.0 5.0 7.1e-30 103.0 5.0 4.9 5 1 1 6 6 6 1 KRI1-like family C-terminal Kri1 PF05178.12 KOG96873.1 - 2.1e-09 37.9 27.5 2.1e-09 37.9 27.5 6.5 5 2 2 7 7 7 1 KRI1-like family Pkinase PF00069.25 KOG96874.1 - 4.7e-59 199.9 0.0 5.6e-59 199.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96874.1 - 2e-29 102.7 0.0 2.6e-29 102.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG96874.1 - 2e-05 24.1 0.0 3.7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOG96874.1 - 0.0028 17.6 0.0 0.0051 16.8 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KOG96874.1 - 0.016 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KOG96874.1 - 0.023 14.3 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Ribosomal_S11 PF00411.19 KOG96875.1 - 6.5e-05 23.3 0.0 0.00011 22.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 Bax1-I PF01027.20 KOG96876.1 - 8.8e-39 133.5 18.1 1.8e-38 132.5 18.1 1.4 1 1 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 HupE_UreJ_2 PF13795.6 KOG96876.1 - 0.0024 17.6 0.2 0.0035 17.0 0.2 1.3 1 0 0 1 1 1 1 HupE / UreJ protein MerC PF03203.14 KOG96876.1 - 0.0057 17.1 6.8 0.0057 17.1 6.8 2.5 1 1 0 2 2 2 1 MerC mercury resistance protein BaxI_1 PF12811.7 KOG96876.1 - 0.0059 16.2 10.2 0.0059 16.2 10.2 2.0 2 0 0 2 2 2 1 Bax inhibitor 1 like MnhB PF04039.13 KOG96876.1 - 0.91 9.9 8.1 0.12 12.7 3.4 2.1 2 1 0 2 2 2 0 Domain related to MnhB subunit of Na+/H+ antiporter DUF4064 PF13273.6 KOG96876.1 - 2.7 8.3 8.8 20 5.5 0.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Ras PF00071.22 KOG96877.1 - 1.3e-29 102.9 0.5 8e-25 87.3 0.8 2.5 2 1 0 2 2 2 2 Ras family Roc PF08477.13 KOG96877.1 - 2.2e-17 63.4 0.8 2.2e-11 44.0 0.2 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG96877.1 - 3.3e-06 26.7 1.4 4.4e-05 23.0 0.8 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOG96877.1 - 0.0082 15.5 3.5 0.12 11.7 1.8 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOG96877.1 - 0.046 13.8 0.0 1 9.5 0.0 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Ribosomal_S19e PF01090.19 KOG96878.1 - 3e-36 124.1 0.1 3.3e-36 124.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Herpes_TAF50 PF03326.13 KOG96879.1 - 1.8 7.1 8.7 1.9 7.0 8.7 1.0 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) MGC-24 PF05283.11 KOG96879.1 - 2.5 8.5 9.3 3.4 8.1 9.3 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin NTP_transf_2 PF01909.23 KOG96880.1 - 4.2e-19 68.6 0.0 4.2e-19 68.6 0.0 2.8 3 1 0 3 3 3 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 KOG96880.1 - 8.2e-15 54.8 1.9 1.1e-14 54.4 0.0 2.3 2 0 0 2 2 2 1 Cid1 family poly A polymerase Polbeta PF18765.1 KOG96880.1 - 0.0018 18.3 0.2 0.0083 16.2 0.0 2.2 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase Pkinase PF00069.25 KOG96881.1 - 3.3e-62 210.2 0.0 3.3e-62 210.2 0.0 2.6 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96881.1 - 1.5e-49 168.6 0.0 3e-49 167.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 KOG96881.1 - 7.3e-24 83.9 1.1 2.3e-23 82.3 0.2 2.4 2 0 0 2 2 2 1 P21-Rho-binding domain PH PF00169.29 KOG96881.1 - 5.9e-13 49.2 0.5 1.2e-12 48.2 0.5 1.6 1 0 0 1 1 1 1 PH domain Pkinase_fungal PF17667.1 KOG96881.1 - 5.5e-06 25.4 0.0 5.5e-06 25.4 0.0 2.6 2 1 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KOG96881.1 - 1.9e-05 24.2 0.0 4e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.6 KOG96881.1 - 3.4e-05 24.2 0.9 3.4e-05 24.2 0.9 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain APH PF01636.23 KOG96881.1 - 0.12 12.3 0.1 0.12 12.3 0.1 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family Det1 PF09737.9 KOG96881.1 - 5.9 5.8 13.1 1.6 7.7 10.0 1.6 2 0 0 2 2 2 0 De-etiolated protein 1 Det1 DCB PF16213.5 KOG96882.1 - 2.5e-48 164.1 0.5 2.5e-48 164.1 0.5 4.0 5 0 0 5 5 5 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 KOG96882.1 - 4e-32 111.3 2.1 4e-32 111.3 2.1 5.6 6 0 0 6 6 6 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 KOG96882.1 - 7e-15 54.3 2.1 3.4e-11 42.0 0.1 3.2 2 1 1 3 3 3 2 C-terminal region of Mon2 protein DUF956 PF06115.11 KOG96882.1 - 0.049 13.3 0.2 0.23 11.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF956) Pet20 PF08692.10 KOG96883.1 - 7.6e-33 114.0 1.3 1.2e-32 113.3 0.1 2.1 2 0 0 2 2 2 1 Mitochondrial protein Pet20 mCpol PF18182.1 KOG96883.1 - 0.077 13.3 0.1 0.22 11.8 0.0 1.8 2 0 0 2 2 2 0 minimal CRISPR polymerase domain PalH PF08733.10 KOG96884.1 - 9.3e-82 274.7 16.7 1.2e-81 274.3 16.7 1.1 1 0 0 1 1 1 1 PalH/RIM21 NOA36 PF06524.12 KOG96884.1 - 0.11 11.7 10.3 0.18 11.1 10.3 1.3 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 KOG96884.1 - 0.21 12.0 14.2 0.54 10.7 14.2 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 KOG96884.1 - 1.8 8.2 7.2 5.8 6.6 7.2 1.9 1 0 0 1 1 1 0 FAM176 family UPF0542 PF15086.6 KOG96884.1 - 3 7.8 5.7 0.32 11.0 0.2 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 RabGAP-TBC PF00566.18 KOG96885.1 - 1.3e-43 149.1 6.3 2.1e-32 112.6 0.7 2.4 2 0 0 2 2 2 2 Rab-GTPase-TBC domain DUF2457 PF10446.9 KOG96885.1 - 0.16 11.1 12.7 0.27 10.3 12.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 KOG96885.1 - 8.9 5.5 11.6 20 4.4 11.6 1.5 1 0 0 1 1 1 0 NOA36 protein TruB_N PF01509.18 KOG96886.1 - 1.4e-40 139.1 0.5 7.9e-39 133.4 0.0 2.7 3 0 0 3 3 3 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 KOG96886.1 - 0.00066 19.8 0.0 0.0023 18.1 0.0 1.9 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Mid1 PF12929.7 KOG96887.1 - 1.6e-126 423.0 18.9 1.8e-126 422.8 18.9 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 KOG96887.1 - 0.012 16.2 6.7 0.49 11.0 6.7 2.8 1 1 0 1 1 1 0 Fz domain AAA PF00004.29 KOG96888.1 - 2.1e-18 67.0 0.1 9.6e-18 64.9 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 KOG96888.1 - 6.7e-16 58.5 0.0 1e-12 48.1 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 KOG96888.1 - 8e-13 48.6 0.0 2.2e-12 47.2 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.15 KOG96888.1 - 5.3e-08 33.0 0.0 2.6e-07 30.8 0.0 2.0 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 KOG96888.1 - 1.2e-06 28.7 0.0 3.8e-06 27.1 0.0 1.9 1 0 0 1 1 1 1 AAA C-terminal domain DNA_pol3_delta PF06144.13 KOG96888.1 - 1.3e-06 28.3 0.4 2.7e-06 27.3 0.1 1.7 2 0 0 2 2 2 1 DNA polymerase III, delta subunit RuvB_N PF05496.12 KOG96888.1 - 5.9e-06 26.1 0.0 1e-05 25.3 0.0 1.5 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOG96888.1 - 7.7e-06 26.4 0.0 1.9e-05 25.1 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 KOG96888.1 - 1.8e-05 24.8 0.1 0.00014 21.9 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 KOG96888.1 - 1.8e-05 24.7 0.5 0.0059 16.6 0.0 3.5 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_11 PF13086.6 KOG96888.1 - 4.1e-05 23.5 0.0 0.00025 20.9 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 KOG96888.1 - 4.4e-05 23.8 0.8 0.3 11.4 0.1 2.7 2 1 1 3 3 2 2 AAA domain DUF815 PF05673.13 KOG96888.1 - 5.6e-05 22.4 0.0 8.4e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ResIII PF04851.15 KOG96888.1 - 8.3e-05 22.7 0.0 0.0043 17.1 0.0 2.3 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 KOG96888.1 - 0.00036 20.3 0.0 0.0012 18.6 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_7 PF12775.7 KOG96888.1 - 0.00047 19.7 0.0 0.002 17.7 0.0 1.9 1 1 1 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 KOG96888.1 - 0.00061 19.6 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KOG96888.1 - 0.0017 18.2 0.0 0.0034 17.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein DEAD PF00270.29 KOG96888.1 - 0.0024 17.7 0.1 0.019 14.8 0.1 2.1 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_18 PF13238.6 KOG96888.1 - 0.0032 18.0 0.0 0.0092 16.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOG96888.1 - 0.0035 17.7 0.1 0.12 12.7 0.1 2.4 1 1 1 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 KOG96888.1 - 0.0075 16.0 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 KOG96888.1 - 0.0077 16.1 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 KOG96888.1 - 0.008 15.7 0.0 4.1 6.8 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein AAA_25 PF13481.6 KOG96888.1 - 0.023 14.3 0.1 0.6 9.7 0.0 2.4 1 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 KOG96888.1 - 0.028 13.8 0.0 0.17 11.2 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KOG96888.1 - 0.031 14.7 0.0 0.058 13.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase TIP49 PF06068.13 KOG96888.1 - 0.032 13.4 0.0 0.053 12.7 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_28 PF13521.6 KOG96888.1 - 0.046 14.0 0.0 0.1 12.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOG96888.1 - 0.062 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SNF2_N PF00176.23 KOG96888.1 - 0.063 12.0 0.0 0.1 11.3 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain TniB PF05621.11 KOG96888.1 - 0.078 12.4 0.0 1.7 8.0 0.0 2.2 1 1 1 2 2 2 0 Bacterial TniB protein Methyltransf_31 PF13847.6 KOG96888.1 - 0.14 12.0 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Cyclin_N PF00134.23 KOG96889.1 - 1.4e-23 83.0 0.0 2.7e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 KOG96889.1 - 4.3e-08 33.7 0.0 8.8e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Cyclin Rcd1 PF04078.13 KOG96890.1 - 5.9e-113 376.5 3.9 6.9e-113 376.2 3.9 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Menin PF05053.13 KOG96890.1 - 2.4 6.4 8.8 3.4 5.9 8.8 1.1 1 0 0 1 1 1 0 Menin Adaptin_N PF01602.20 KOG96891.1 - 7e-122 407.6 13.9 8.6e-122 407.4 13.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 KOG96891.1 - 2.1e-46 157.8 1.9 5.4e-46 156.5 1.9 1.8 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 KOG96891.1 - 3.9e-27 94.7 0.0 1.1e-26 93.2 0.0 1.8 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 KOG96891.1 - 3.4e-13 49.8 0.1 4.5e-07 30.2 0.0 4.4 3 2 1 4 4 4 2 HEAT repeats Cnd1 PF12717.7 KOG96891.1 - 3.4e-05 23.9 13.3 0.00052 20.1 1.0 3.9 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KOG96891.1 - 0.00095 19.2 2.6 3.8 8.0 0.0 6.0 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 KOG96891.1 - 0.06 13.9 0.3 0.82 10.2 0.1 3.2 3 1 0 3 3 3 0 HEAT-like repeat TPR_20 PF14561.6 KOG96891.1 - 0.19 12.1 1.1 3.4 8.1 0.0 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat RRM_1 PF00076.22 KOG96892.1 - 2.5e-17 62.5 0.4 9.7e-08 31.7 0.1 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOG96892.1 - 0.00021 21.4 0.0 0.00044 20.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 KOG96892.1 - 0.0014 18.4 0.2 0.044 13.7 0.0 2.7 2 1 0 2 2 2 1 Occluded RNA-recognition motif SET_assoc PF11767.8 KOG96892.1 - 0.0093 15.6 0.1 0.75 9.5 0.0 2.7 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated TYA PF01021.19 KOG96893.1 - 7.6e-33 112.8 9.3 7.6e-33 112.8 9.3 2.7 3 0 0 3 3 3 1 TYA transposon protein Ribosomal_L27A PF00828.19 KOG96894.1 - 2.2e-33 115.7 1.8 2.9e-33 115.3 0.4 1.8 2 0 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A WSC PF01822.19 KOG96895.1 - 3.4e-10 40.0 11.3 3.4e-10 40.0 11.3 3.2 2 1 0 2 2 2 1 WSC domain SKG6 PF08693.10 KOG96895.1 - 0.0041 16.5 3.3 0.0041 16.5 3.3 3.0 3 0 0 3 3 3 1 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.15 KOG96895.1 - 0.0043 16.8 0.6 0.0088 15.8 0.6 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 DUF3147 PF11345.8 KOG96895.1 - 0.048 14.0 0.2 0.085 13.2 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3147) Syndecan PF01034.20 KOG96895.1 - 0.094 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain CbiM PF01891.16 KOG96895.1 - 0.11 12.3 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Cobalt uptake substrate-specific transmembrane region EphA2_TM PF14575.6 KOG96895.1 - 0.13 13.1 2.7 0.19 12.6 0.0 2.6 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Orf78 PF06024.12 KOG96895.1 - 0.16 12.2 0.0 0.16 12.2 0.0 3.2 2 1 0 2 2 2 0 Orf78 (ac78) Insulin_TMD PF17870.1 KOG96895.1 - 0.27 11.3 0.6 0.55 10.4 0.6 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment TMEM190 PF15431.6 KOG96895.1 - 2.5 8.3 0.0 2.5 8.3 0.0 3.7 3 1 1 4 4 4 0 Transmembrane protein 190 RNase_P_pop3 PF08228.11 KOG96896.1 - 5.3e-63 211.8 0.7 6.7e-63 211.5 0.7 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 DnaG_DnaB_bind PF08278.11 KOG96896.1 - 0.072 13.7 0.0 0.12 13.0 0.0 1.3 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding Aha1_N PF09229.11 KOG96897.1 - 2.2e-28 99.2 0.0 3.1e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal ERG4_ERG24 PF01222.17 KOG96898.1 - 2e-186 620.0 10.9 2.2e-186 619.8 10.9 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 KOG96898.1 - 6.2e-07 29.2 0.6 1.3e-06 28.1 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF1700 PF08006.11 KOG96898.1 - 0.86 9.1 4.6 4.1 6.9 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1700) RHH_3 PF12651.7 KOG96899.1 - 0.38 10.7 1.6 6.5 6.8 0.1 3.2 3 0 0 3 3 3 0 Ribbon-helix-helix domain LapA_dom PF06305.11 KOG96899.1 - 4.6 7.1 9.7 13 5.7 0.1 3.5 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain PH PF00169.29 KOG96900.1 - 7.6e-10 39.3 0.3 2.6e-08 34.3 0.0 2.5 2 0 0 2 2 2 1 PH domain Pkinase_C PF00433.24 KOG96900.1 - 0.067 13.9 1.5 0.4 11.4 0.1 3.1 2 0 0 2 2 2 0 Protein kinase C terminal domain Abhydrolase_1 PF00561.20 KOG96901.1 - 8.4e-80 268.1 0.0 9.9e-80 267.9 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOG96901.1 - 0.00082 20.0 0.0 0.0014 19.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOG96901.1 - 0.079 12.2 0.0 0.35 10.1 0.0 1.9 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Miga PF10265.9 KOG96901.1 - 2.4 7.0 5.4 3.4 6.5 5.4 1.1 1 0 0 1 1 1 0 Mitoguardin HCO3_cotransp PF00955.21 KOG96902.1 - 2.1e-79 267.7 17.8 1.1e-42 146.6 5.5 2.1 1 1 1 2 2 2 2 HCO3- transporter family 2-Hacid_dh_C PF02826.19 KOG96903.1 - 3.3e-56 189.4 0.0 7.3e-56 188.3 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOG96903.1 - 5e-12 45.6 0.0 7.3e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain IlvN PF07991.12 KOG96903.1 - 0.00035 20.2 0.0 0.00076 19.1 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 KOG96903.1 - 0.00078 19.6 0.0 0.0021 18.3 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 KOG96903.1 - 0.0025 17.9 0.1 0.15 12.1 0.0 2.9 2 1 1 3 3 3 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain RIF5_SNase_1 PF18187.1 KOG96903.1 - 0.025 14.3 0.0 0.044 13.5 0.0 1.4 1 0 0 1 1 1 0 TbRIF5 SNase domain 1 DUF2171 PF09939.9 KOG96903.1 - 0.065 13.5 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2171) Gp_dh_N PF00044.24 KOG96903.1 - 0.073 13.4 0.1 0.27 11.6 0.1 2.0 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain TIMELESS PF04821.14 KOG96904.1 - 2.7e-92 309.0 0.3 2.7e-92 309.0 0.3 3.1 4 0 0 4 4 4 2 Timeless protein Sec2p PF06428.11 KOG96905.1 - 3.6e-28 97.4 11.5 3.6e-28 97.4 11.5 3.9 3 1 0 3 3 3 1 GDP/GTP exchange factor Sec2p Baculo_PEP_C PF04513.12 KOG96905.1 - 0.57 10.2 14.5 29 4.7 10.4 3.2 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FH2 PF02181.23 KOG96906.1 - 1.2e-91 307.7 6.8 1.2e-91 307.7 6.8 3.9 3 2 1 4 4 4 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 KOG96906.1 - 5.6e-46 156.6 3.3 5.6e-46 156.6 3.3 4.4 4 0 0 4 4 4 2 Diaphanous FH3 Domain Drf_GBD PF06371.13 KOG96906.1 - 1.9e-24 86.3 0.7 9.8e-19 67.6 0.0 5.9 5 1 0 6 6 6 2 Diaphanous GTPase-binding Domain AA_permease PF00324.21 KOG96907.1 - 1.7e-50 172.0 18.6 1.9e-50 171.9 18.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG96907.1 - 4.1e-09 35.8 19.0 5.7e-09 35.3 19.0 1.2 1 0 0 1 1 1 1 Amino acid permease DUF3742 PF12553.8 KOG96907.1 - 0.11 12.7 0.3 0.11 12.7 0.3 2.3 2 2 1 3 3 3 0 Protein of unknown function (DUF3742) AA_permease PF00324.21 KOG96908.1 - 7.1e-54 183.2 17.8 7.9e-54 183.0 17.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG96908.1 - 4.3e-12 45.6 17.3 5.7e-12 45.2 17.3 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3767 PF12597.8 KOG96908.1 - 0.14 12.0 0.3 0.36 10.7 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) RhodobacterPufX PF11511.8 KOG96908.1 - 0.15 11.7 0.7 0.83 9.3 0.5 2.4 2 0 0 2 2 2 0 Intrinsic membrane protein PufX DUF4149 PF13664.6 KOG96908.1 - 0.73 10.2 11.3 0.049 14.0 3.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4149) PI3_PI4_kinase PF00454.27 KOG96909.1 - 2.7e-29 102.7 0.5 1.2e-28 100.6 0.1 2.2 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 KOG96909.1 - 7e-21 73.9 4.9 2.9e-20 72.0 1.1 2.7 2 0 0 2 2 2 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.20 KOG96909.1 - 4.5e-06 26.2 0.7 1.1e-05 24.9 0.7 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Na_Ca_ex_C PF16494.5 KOG96909.1 - 0.088 13.3 0.3 0.48 10.9 0.1 2.2 2 0 0 2 2 2 0 C-terminal extension of sodium/calcium exchanger domain DUF148 PF02520.17 KOG96909.1 - 0.13 12.4 2.6 0.3 11.2 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function DUF148 Ist1 PF03398.14 KOG96910.1 - 2.3e-54 183.7 4.9 4e-54 183.0 4.9 1.4 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Sox_N PF12444.8 KOG96910.1 - 7.3 7.8 6.7 3.2 9.0 0.3 2.6 2 0 0 2 2 2 0 Sox developmental protein N terminal CRAL_TRIO PF00650.20 KOG96911.1 - 4.6e-39 133.7 0.0 8e-39 132.9 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KOG96911.1 - 1.9e-16 59.9 0.2 3.9e-16 59.0 0.2 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 KOG96911.1 - 0.003 17.7 0.0 0.0049 17.0 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain YIF1 PF03878.15 KOG96912.1 - 6.4e-76 255.0 5.4 6.4e-76 255.0 5.4 1.4 2 0 0 2 2 2 1 YIF1 Yip1 PF04893.17 KOG96912.1 - 1e-06 28.6 2.5 2.1e-06 27.6 2.5 1.5 1 0 0 1 1 1 1 Yip1 domain DUF1744 PF08490.12 KOG96913.1 - 6.7e-145 482.6 12.0 1.1e-144 482.0 12.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 KOG96913.1 - 9.3e-85 284.7 4.3 3.9e-84 282.7 4.3 2.2 1 1 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 KOG96913.1 - 2.4e-15 56.2 3.0 1.8e-11 43.5 0.2 4.2 3 1 0 3 3 3 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 KOG96913.1 - 5.2e-07 29.6 0.5 3.4e-06 26.9 0.5 2.2 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 KOG96913.1 - 1.2e-05 25.3 0.1 0.00012 22.1 0.0 2.9 2 0 0 2 2 2 1 RNase_H superfamily zf-DNA_Pol PF08996.10 KOG96913.1 - 0.05 13.4 0.8 0.16 11.7 0.8 1.8 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger NAPRTase_C PF17956.1 KOG96913.1 - 0.056 13.9 3.0 0.1 13.0 0.1 3.0 3 0 0 3 3 3 0 Nicotinate phosphoribosyltransferase C-terminal domain zf_UBZ PF18439.1 KOG96913.1 - 0.48 10.1 1.9 2 8.1 0.1 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Cytochrome_C7 PF14522.6 KOG96913.1 - 4.7 7.3 7.7 0.87 9.6 3.6 1.9 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c Cytochrom_c3_2 PF14537.6 KOG96913.1 - 6.7 7.2 8.1 1.5 9.3 4.4 1.8 2 0 0 2 2 2 0 Cytochrome c3 ORC5_C PF14630.6 KOG96914.1 - 1.7e-61 208.3 0.4 2.5e-61 207.7 0.2 1.4 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 KOG96914.1 - 2.8e-08 34.3 0.0 6.1e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOG96914.1 - 3.7e-06 27.3 0.0 7.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 KOG96914.1 - 0.032 14.2 0.1 3.3 7.6 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.6 KOG96914.1 - 0.2 12.0 0.0 0.61 10.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain Yae1_N PF09811.9 KOG96915.1 - 1.3e-13 50.4 3.6 2.7e-13 49.4 3.6 1.5 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Thioredoxin_5 PF13743.6 KOG96915.1 - 0.019 14.6 0.3 0.025 14.2 0.3 1.3 1 1 0 1 1 1 0 Thioredoxin HMA PF00403.26 KOG96916.1 - 4.2e-08 33.5 0.2 5.4e-08 33.2 0.2 1.2 1 0 0 1 1 1 1 Heavy-metal-associated domain Dsl1_N PF11988.8 KOG96917.1 - 2.7e-129 431.2 25.6 4.7e-129 430.4 25.6 1.4 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 N terminal Dsl1_C PF11989.8 KOG96917.1 - 7.8e-89 296.6 6.3 7.8e-89 296.6 6.3 2.5 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal SDA1 PF05285.12 KOG96917.1 - 1.1 8.7 19.7 1.7 8.0 19.7 1.2 1 0 0 1 1 1 0 SDA1 VASt PF16016.5 KOG96918.1 - 9e-15 55.4 0.1 2.2e-14 54.1 0.1 1.7 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain PH PF00169.29 KOG96918.1 - 2.2e-12 47.4 2.7 6.3e-12 45.9 0.4 2.7 2 0 0 2 2 2 1 PH domain BAR_3 PF16746.5 KOG96918.1 - 1.4e-08 34.7 1.3 1.4e-08 34.7 1.3 2.8 3 1 0 3 3 3 1 BAR domain of APPL family BofA PF07441.11 KOG96918.1 - 4.1 7.7 8.1 9.9 6.4 8.1 1.6 1 0 0 1 1 1 0 SigmaK-factor processing regulatory protein BofA Pterin_bind PF00809.22 KOG96919.1 - 1.2e-55 188.9 0.1 8.2e-55 186.1 0.1 2.2 1 1 0 1 1 1 1 Pterin binding enzyme FolB PF02152.18 KOG96919.1 - 3.3e-36 124.2 0.1 8.3e-17 61.8 0.1 2.5 2 0 0 2 2 2 2 Dihydroneopterin aldolase HPPK PF01288.20 KOG96919.1 - 1.3e-33 115.9 0.0 4.2e-33 114.2 0.0 1.9 2 0 0 2 2 2 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) zf-CCHC PF00098.23 KOG96920.1 - 2.5e-53 175.9 55.6 2.2e-08 33.8 1.7 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 KOG96920.1 - 4.4e-13 48.7 43.5 0.01 15.6 0.4 7.1 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 KOG96920.1 - 6.9e-07 29.1 46.9 0.096 12.7 0.4 7.0 1 1 6 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.6 KOG96920.1 - 9.1e-06 25.3 36.2 0.38 10.5 0.1 7.0 3 3 4 7 7 7 5 GAG-polyprotein viral zinc-finger zf-C2H2_10 PF16588.5 KOG96920.1 - 0.011 15.5 1.7 0.011 15.5 1.7 6.5 6 1 1 7 7 7 0 C2H2 zinc-finger RTC4 PF14474.6 KOG96921.1 - 2.9e-31 108.1 0.0 6.1e-31 107.1 0.0 1.6 1 0 0 1 1 1 1 RTC4-like domain ANAPC4_WD40 PF12894.7 KOG96922.1 - 1.6e-12 47.6 0.5 0.058 13.7 0.0 5.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOG96922.1 - 2.9e-11 43.7 9.2 5.1e-05 23.9 0.4 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat WD40_like PF17005.5 KOG96922.1 - 0.00024 20.6 0.3 0.08 12.3 0.1 2.7 1 1 1 2 2 2 2 WD40-like domain Hira PF07569.11 KOG96922.1 - 0.0048 16.7 1.3 8.5 6.0 0.4 3.8 2 1 0 3 3 3 2 TUP1-like enhancer of split DUF4130 PF13566.6 KOG96922.1 - 0.077 13.0 0.2 0.16 12.0 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4130 MRP-L46 PF11788.8 KOG96923.1 - 2.3e-36 125.2 0.0 3.7e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 DUF3642 PF12182.8 KOG96923.1 - 0.059 13.6 0.3 0.15 12.3 0.1 1.8 2 0 0 2 2 2 0 Bacterial lipoprotein SHIRT PF18655.1 KOG96923.1 - 0.12 13.0 2.2 4.2 8.0 2.2 2.6 1 1 0 1 1 1 0 SHIRT domain CTD_bind PF04818.13 KOG96924.1 - 4.4e-07 30.6 0.0 1.1e-06 29.3 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.22 KOG96924.1 - 1.8e-06 27.7 0.0 3.4e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spo7_2_N PF15407.6 KOG96924.1 - 0.011 15.3 0.0 0.03 13.9 0.0 1.8 1 1 0 1 1 1 0 Sporulation protein family 7 FAM27 PF15832.5 KOG96924.1 - 0.017 15.7 0.2 0.039 14.5 0.2 1.6 1 0 0 1 1 1 0 FAM27 D and E protein family RNA_bind PF08675.11 KOG96924.1 - 0.027 14.5 0.0 0.06 13.4 0.0 1.5 1 0 0 1 1 1 0 RNA binding domain RRM_7 PF16367.5 KOG96924.1 - 0.088 12.9 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif AAA_23 PF13476.6 KOG96925.1 - 1.2e-37 130.4 1.4 1.2e-37 130.4 1.4 8.6 2 1 4 6 6 2 1 AAA domain Rad50_zn_hook PF04423.14 KOG96925.1 - 1e-17 63.7 4.4 1e-17 63.7 4.4 7.0 4 0 0 4 4 4 1 Rad50 zinc hook motif SMC_N PF02463.19 KOG96925.1 - 1.9e-07 30.7 0.1 1.9e-07 30.7 0.1 4.9 2 1 0 2 2 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 KOG96925.1 - 5e-06 26.7 0.0 1.2e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 KOG96925.1 - 0.00016 21.5 32.5 0.00016 21.5 32.5 6.2 1 1 2 3 3 2 1 AAA ATPase domain AAA_29 PF13555.6 KOG96925.1 - 0.00085 19.0 0.0 0.0021 17.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain CENP-F_leu_zip PF10473.9 KOG96925.1 - 0.0071 16.4 16.6 0.0071 16.4 16.6 8.6 2 2 6 8 8 6 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_16 PF13191.6 KOG96925.1 - 0.029 14.8 4.7 0.055 13.9 0.0 3.4 3 0 0 3 3 3 0 AAA ATPase domain AAA_13 PF13166.6 KOG96925.1 - 0.032 12.9 0.0 0.032 12.9 0.0 7.6 2 1 5 8 8 6 0 AAA domain Phospholamban PF04272.14 KOG96925.1 - 0.11 12.0 1.1 0.53 9.8 0.2 2.7 2 0 0 2 2 2 0 Phospholamban AAA_22 PF13401.6 KOG96925.1 - 0.23 11.7 0.0 0.23 11.7 0.0 5.1 4 1 0 4 4 4 0 AAA domain CRISPR_Cas2 PF09827.9 KOG96925.1 - 1.6 9.0 6.4 8.4 6.7 0.2 4.9 3 1 1 4 4 4 0 CRISPR associated protein Cas2 Cryptochrome_C PF12546.8 KOG96925.1 - 8 7.1 8.6 1 10.0 2.5 2.8 2 0 0 2 2 1 0 Blue/Ultraviolet sensing protein C terminal FGGY_C PF02782.16 KOG96926.1 - 7.8e-27 94.3 0.0 1.1e-26 93.8 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 KOG96926.1 - 8.4e-08 32.1 0.0 1.6e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain RNA_pol_I_A49 PF06870.12 KOG96927.1 - 5.5e-126 420.5 0.9 6.3e-126 420.3 0.9 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor tRNA-synt_1e PF01406.19 KOG96928.1 - 1.4e-147 490.9 0.2 1.4e-147 490.9 0.2 1.5 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 KOG96928.1 - 7.9e-09 34.7 0.9 1.1e-05 24.4 0.1 2.6 2 0 0 2 2 2 2 tRNA synthetases class I (M) Phage_int_SAM_5 PF13102.6 KOG96928.1 - 0.00013 22.2 3.3 0.025 14.9 0.3 3.1 2 0 0 2 2 2 2 Phage integrase SAM-like domain tRNA-synt_1 PF00133.22 KOG96928.1 - 0.00026 19.4 1.2 0.0023 16.3 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.18 KOG96928.1 - 0.0022 17.0 0.1 0.005 15.8 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (K) RNA_pol_Rpb1_3 PF04983.18 KOG96928.1 - 0.11 12.5 0.0 0.27 11.1 0.0 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 3 ECH_2 PF16113.5 KOG96928.1 - 0.11 12.0 1.6 0.11 12.0 0.0 1.8 2 0 0 2 2 2 0 Enoyl-CoA hydratase/isomerase NAP PF00956.18 KOG96929.1 - 3e-09 36.4 5.2 1.6e-08 34.1 5.2 1.9 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) Cir_N PF10197.9 KOG96930.1 - 3.4e-12 46.4 7.6 8.3e-12 45.1 7.6 1.7 1 0 0 1 1 1 1 N-terminal domain of CBF1 interacting co-repressor CIR CWC25 PF12542.8 KOG96930.1 - 4.4e-12 46.8 1.4 4.4e-12 46.8 1.4 1.9 2 0 0 2 2 2 1 Pre-mRNA splicing factor BAR_3 PF16746.5 KOG96930.1 - 0.045 13.5 0.6 0.045 13.5 0.6 1.8 2 0 0 2 2 2 0 BAR domain of APPL family SUI1 PF01253.22 KOG96931.1 - 8.7e-27 93.5 0.3 1.2e-26 93.1 0.3 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 ANTH PF07651.16 KOG96932.1 - 1.4e-74 250.6 0.1 1.4e-74 250.6 0.1 3.1 3 1 1 4 4 4 1 ANTH domain I_LWEQ PF01608.17 KOG96932.1 - 4.1e-49 166.7 8.0 4.1e-49 166.7 8.0 5.4 3 2 2 5 5 5 1 I/LWEQ domain Glyco_hydro_67N PF03648.14 KOG96932.1 - 0.9 9.8 7.2 5.3 7.3 0.1 3.3 2 0 0 2 2 2 0 Glycosyl hydrolase family 67 N-terminus TFIIA PF03153.13 KOG96932.1 - 1.5 8.8 43.8 0.031 14.3 26.3 2.5 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit FAA_hydro_N_2 PF18288.1 KOG96932.1 - 8 7.0 9.9 0.53 10.7 1.0 3.8 1 1 2 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 ATG_C PF09333.11 KOG96933.1 - 6.9e-31 106.5 0.2 1.9e-30 105.1 0.2 1.8 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain ATG2_CAD PF13329.6 KOG96933.1 - 1.1e-28 99.9 0.9 1.1e-28 99.9 0.9 2.6 2 1 0 2 2 2 1 Autophagy-related protein 2 CAD motif SesA PF17107.5 KOG96933.1 - 0.078 13.2 0.0 0.49 10.6 0.0 2.4 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases G6PD_C PF02781.16 KOG96934.1 - 1.2e-109 366.0 0.0 1.6e-109 365.6 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 KOG96934.1 - 1.7e-58 198.2 0.0 7.8e-58 196.0 0.0 1.9 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Fe_hyd_lg_C PF02906.14 KOG96935.1 - 9.5e-43 146.6 0.0 1.4e-42 146.1 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Peptidase_C1_2 PF03051.15 KOG96936.1 - 4.3e-178 592.6 0.3 5e-178 592.4 0.3 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 KOG96936.1 - 4.1e-06 27.0 0.0 0.14 12.3 0.0 2.4 2 0 0 2 2 2 2 Papain family cysteine protease Peptidase_S8 PF00082.22 KOG96937.1 - 1e-36 126.7 1.5 1e-36 126.7 1.5 2.4 2 1 0 2 2 2 1 Subtilase family P_proprotein PF01483.20 KOG96937.1 - 3.2e-25 88.0 1.0 6.2e-25 87.0 0.6 1.8 2 0 0 2 2 2 1 Proprotein convertase P-domain DUF1180 PF06679.12 KOG96937.1 - 0.0021 18.5 0.1 0.0049 17.3 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) LapA_dom PF06305.11 KOG96937.1 - 0.023 14.5 0.2 0.057 13.2 0.2 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain CW_binding_1 PF01473.20 KOG96937.1 - 0.092 13.1 0.1 0.27 11.6 0.1 1.9 1 0 0 1 1 1 0 Putative cell wall binding repeat Ytp1 PF10355.9 KOG96938.1 - 2e-57 194.5 20.7 1.9e-55 188.0 20.7 2.3 1 1 0 1 1 1 1 Protein of unknown function (Ytp1) DUF4395 PF14340.6 KOG96938.1 - 0.098 13.0 0.1 0.098 13.0 0.1 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4395) Med16 PF11635.8 KOG96939.1 - 1.2e-204 681.5 17.2 1.4e-204 681.3 17.2 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 Globin PF00042.22 KOG96940.1 - 4.2e-05 24.1 0.1 0.00012 22.6 0.1 1.8 1 1 0 1 1 1 1 Globin EXOSC1 PF10447.9 KOG96942.1 - 6.1e-44 149.1 1.1 1.8e-42 144.4 0.1 2.2 2 0 0 2 2 2 2 Exosome component EXOSC1/CSL4 CRAL_TRIO PF00650.20 KOG96943.1 - 1.8e-37 128.5 0.0 2.9e-37 127.9 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KOG96943.1 - 1e-17 64.0 1.2 2.2e-17 63.0 1.2 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Elongin_A PF06881.11 KOG96944.1 - 5.1e-21 75.2 15.4 7.1e-18 65.1 12.8 3.0 2 1 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Sacchrp_dh_NADP PF03435.18 KOG96944.1 - 0.089 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DapB_C PF05173.14 KOG96944.1 - 0.1 12.6 0.9 0.51 10.4 0.2 2.1 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, C-terminus GST_C PF00043.25 KOG96945.1 - 7.6e-27 93.4 0.0 1.8e-26 92.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KOG96945.1 - 1.3e-20 73.5 0.0 4.4e-20 71.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 KOG96945.1 - 1.5e-09 38.1 0.0 3.1e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOG96945.1 - 1.1e-08 35.3 0.0 3e-08 33.8 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KOG96945.1 - 1.9e-06 28.0 0.0 6.9e-06 26.2 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOG96945.1 - 0.012 15.6 0.0 0.03 14.4 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DnaJ PF00226.31 KOG96946.1 - 1.9e-24 85.5 1.1 6.4e-24 83.9 1.1 2.0 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 KOG96946.1 - 2.1e-08 34.2 6.0 2.1e-08 34.2 6.0 3.1 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KOG96946.1 - 8.2e-07 29.3 3.8 0.01 16.6 0.7 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KOG96946.1 - 1.4e-06 28.4 9.3 0.0016 18.8 2.0 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 KOG96946.1 - 1.5e-06 28.5 10.0 0.0012 19.2 2.4 3.2 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 KOG96946.1 - 3.4e-06 27.2 3.4 3.4e-06 27.2 3.4 2.9 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KOG96946.1 - 0.018 15.0 11.7 0.029 14.4 1.6 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger SID PF11778.8 KOG96947.1 - 4e-47 159.7 3.7 1e-46 158.4 3.7 1.7 1 0 0 1 1 1 1 Septation initiation KASH_CCD PF14662.6 KOG96947.1 - 0.0019 18.1 19.8 0.0019 18.1 19.8 2.4 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH GAS PF13851.6 KOG96947.1 - 0.0022 17.4 20.4 0.0022 17.4 20.4 3.2 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding HemX PF04375.14 KOG96947.1 - 0.013 14.8 0.8 0.013 14.8 0.8 3.2 2 1 1 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase TSNAXIP1_N PF15739.5 KOG96947.1 - 0.015 15.6 1.5 0.015 15.6 1.5 3.8 4 0 0 4 4 4 0 Translin-associated factor X-interacting N-terminus UPF0242 PF06785.11 KOG96947.1 - 0.11 12.5 39.5 0.56 10.3 19.6 3.2 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus TolA_bind_tri PF16331.5 KOG96947.1 - 0.99 9.5 15.1 2.2 8.4 5.0 3.8 2 1 1 4 4 4 0 TolA binding protein trimerisation T3SSipB PF16535.5 KOG96947.1 - 1.4 9.4 13.5 11 6.5 0.2 3.6 2 2 1 3 3 3 0 Type III cell invasion protein SipB ATG16 PF08614.11 KOG96947.1 - 1.9 8.7 34.7 1.2 9.4 3.8 3.4 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 KOG96947.1 - 5.2 6.4 31.2 0.064 12.7 17.2 2.5 2 0 0 2 2 2 0 Golgin subfamily A member 5 PI3K_P85_iSH2 PF16454.5 KOG96947.1 - 7.5 6.1 28.5 0.047 13.3 3.4 3.4 1 1 1 2 2 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FlaC_arch PF05377.11 KOG96947.1 - 8.6 6.8 25.7 15 6.0 1.8 5.3 3 1 2 5 5 5 0 Flagella accessory protein C (FlaC) G-patch PF01585.23 KOG96948.1 - 1.5e-14 53.6 1.8 3.2e-14 52.5 1.8 1.6 1 0 0 1 1 1 1 G-patch domain R3H PF01424.22 KOG96948.1 - 1.2e-05 25.2 0.0 2.7e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 R3H domain Peptidase_C54 PF03416.19 KOG96949.1 - 3e-81 272.9 0.0 3.8e-81 272.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Ssu72 PF04722.13 KOG96950.1 - 1.7e-84 282.1 0.0 1.9e-84 282.0 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein POP1 PF06978.11 KOG96951.1 - 5.5e-74 248.6 11.4 5.5e-74 248.6 11.4 1.9 2 0 0 2 2 2 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 KOG96951.1 - 1e-30 105.9 2.2 2.5e-30 104.7 2.2 1.7 1 0 0 1 1 1 1 POPLD (NUC188) domain Adenylsucc_synt PF00709.21 KOG96952.1 - 1.8e-176 587.2 0.0 2.1e-176 587.0 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Glyco_transf_22 PF03901.17 KOG96953.1 - 1.4e-101 340.8 31.2 1.7e-101 340.5 31.2 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family MgsA_C PF12002.8 KOG96954.1 - 4.1e-52 176.5 0.1 1.2e-51 175.0 0.1 1.8 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 KOG96954.1 - 4.1e-20 71.9 2.0 4.6e-20 71.7 0.2 2.0 2 0 0 2 2 1 1 AAA C-terminal domain AAA PF00004.29 KOG96954.1 - 6.3e-15 55.8 0.2 1.9e-14 54.2 0.1 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOG96954.1 - 7.8e-13 48.5 0.1 5.4e-12 45.7 0.1 2.1 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 KOG96954.1 - 4.7e-08 33.1 0.0 1.6e-07 31.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOG96954.1 - 2.2e-07 31.4 0.2 0.00016 22.1 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 KOG96954.1 - 8.1e-07 29.1 0.0 1.6e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOG96954.1 - 2.6e-05 24.5 3.2 0.0014 18.9 0.1 3.0 2 1 1 3 3 2 1 AAA domain Sigma54_activat PF00158.26 KOG96954.1 - 3.2e-05 23.7 0.1 0.00018 21.2 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 KOG96954.1 - 8.5e-05 22.0 0.3 0.13 11.6 0.1 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI zf_C2HC_14 PF18574.1 KOG96954.1 - 0.00029 20.6 0.1 0.0011 18.7 0.1 1.9 1 0 0 1 1 1 1 C2HC Zing finger domain TniB PF05621.11 KOG96954.1 - 0.00031 20.2 0.1 0.00095 18.6 0.1 1.8 1 1 0 1 1 1 1 Bacterial TniB protein RsgA_GTPase PF03193.16 KOG96954.1 - 0.0011 18.9 0.6 0.42 10.5 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase TIP49 PF06068.13 KOG96954.1 - 0.0018 17.6 0.0 0.0056 15.9 0.0 1.8 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 KOG96954.1 - 0.0022 18.1 0.0 0.0072 16.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ResIII PF04851.15 KOG96954.1 - 0.0033 17.4 1.7 0.14 12.1 0.8 2.6 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.6 KOG96954.1 - 0.0042 17.2 0.1 0.017 15.2 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain DUF3074 PF11274.8 KOG96954.1 - 0.0052 16.8 0.3 0.012 15.6 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) IstB_IS21 PF01695.17 KOG96954.1 - 0.0063 16.3 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.6 KOG96954.1 - 0.0065 16.8 3.6 0.57 10.5 0.0 2.7 2 1 1 3 3 2 1 AAA domain AAA_24 PF13479.6 KOG96954.1 - 0.0076 16.0 0.0 0.02 14.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 KOG96954.1 - 0.0086 16.3 0.3 0.029 14.6 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 KOG96954.1 - 0.0088 16.6 0.0 0.022 15.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOG96954.1 - 0.0092 15.7 0.0 0.027 14.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 KOG96954.1 - 0.012 14.8 0.0 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 KOG96954.1 - 0.012 15.9 0.0 0.043 14.2 0.0 2.0 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 KOG96954.1 - 0.017 15.0 0.0 0.035 14.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 KOG96954.1 - 0.027 14.0 0.1 0.051 13.1 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 KOG96954.1 - 0.03 14.6 0.0 0.7 10.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KOG96954.1 - 0.038 14.5 0.2 0.11 13.0 0.2 2.0 1 1 0 1 1 1 0 ABC transporter RNA_pol_Rpb5_N PF03871.14 KOG96954.1 - 0.072 13.7 0.0 0.21 12.2 0.0 1.8 1 0 0 1 1 1 0 RNA polymerase Rpb5, N-terminal domain MMR_HSR1 PF01926.23 KOG96954.1 - 0.11 12.6 0.1 0.31 11.1 0.0 1.9 2 0 0 2 2 1 0 50S ribosome-binding GTPase Metallophos PF00149.28 KOG96955.1 - 4e-11 43.8 1.8 9.7e-11 42.5 1.8 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase FBPase_2 PF06874.11 KOG96955.1 - 0.00016 20.2 0.3 0.057 11.7 0.1 2.1 1 1 1 2 2 2 2 Firmicute fructose-1,6-bisphosphatase Metallophos_2 PF12850.7 KOG96955.1 - 0.0062 16.7 0.0 0.0094 16.2 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain OppC_N PF12911.7 KOG96955.1 - 0.082 12.9 0.6 0.14 12.1 0.1 1.6 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C DUF4372 PF14294.6 KOG96955.1 - 0.14 12.3 0.7 1.2 9.3 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4372) Rap1-DNA-bind PF09197.10 KOG96956.1 - 5.3e-47 158.9 6.6 1.8e-45 153.9 0.8 3.1 2 1 0 2 2 2 2 Rap1, DNA-binding Rap1_C PF11626.8 KOG96956.1 - 2.8e-24 85.0 0.0 2.6e-23 81.9 0.0 2.5 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain BRCT_2 PF16589.5 KOG96956.1 - 5.6e-19 68.3 0.3 3.5e-17 62.6 0.0 3.3 4 0 0 4 4 4 1 BRCT domain, a BRCA1 C-terminus domain Myb_DNA-binding PF00249.31 KOG96956.1 - 4.8e-14 52.3 1.8 1.7e-10 40.9 0.0 4.6 4 1 0 4 4 4 1 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.11 KOG96956.1 - 1.8e-09 37.6 0.5 5.2e-05 23.3 0.0 2.6 2 0 0 2 2 2 2 Rap1 Myb domain Myb_DNA-bind_6 PF13921.6 KOG96956.1 - 0.0018 18.5 1.6 0.77 10.1 0.0 4.0 5 0 0 5 5 5 1 Myb-like DNA-binding domain SLIDE PF09111.10 KOG96956.1 - 0.087 12.9 0.6 0.77 9.8 0.0 2.7 3 0 0 3 3 3 0 SLIDE LIG3_BRCT PF16759.5 KOG96956.1 - 0.33 11.3 1.6 0.77 10.1 0.0 2.5 3 0 0 3 3 3 0 DNA ligase 3 BRCT domain PAPA-1 PF04795.12 KOG96957.1 - 2.5e-20 73.1 3.2 2.5e-20 73.1 3.2 3.6 3 1 0 3 3 3 1 PAPA-1-like conserved region Corazonin PF17308.2 KOG96958.1 - 0.011 16.1 0.5 0.016 15.5 0.5 1.3 1 0 0 1 1 1 0 Pro-corazonin Translin PF01997.16 KOG96958.1 - 0.057 13.4 1.8 0.11 12.5 0.6 1.9 1 1 1 2 2 2 0 Translin family Neugrin PF06413.11 KOG96959.1 - 6.5e-07 29.6 1.7 1e-06 29.0 0.8 1.9 1 1 0 1 1 1 1 Neugrin Sigma70_r4 PF04545.16 KOG96959.1 - 0.00091 18.7 0.0 0.0018 17.7 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 MarR_2 PF12802.7 KOG96959.1 - 0.0019 18.0 0.0 0.0033 17.3 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_11 PF08279.12 KOG96959.1 - 0.003 17.5 0.0 0.0084 16.0 0.0 1.8 1 0 0 1 1 1 1 HTH domain MarR PF01047.22 KOG96959.1 - 0.0057 16.6 0.0 0.023 14.6 0.0 2.0 2 0 0 2 2 2 1 MarR family HTH_32 PF13565.6 KOG96959.1 - 0.014 16.0 0.7 0.024 15.2 0.1 1.8 2 0 0 2 2 2 0 Homeodomain-like domain HTH_7 PF02796.15 KOG96959.1 - 0.016 15.3 0.0 0.2 11.8 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 KOG96959.1 - 0.045 13.6 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain HTH_28 PF13518.6 KOG96959.1 - 0.07 13.3 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 KOG96959.1 - 0.079 12.4 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 DUF3987 PF13148.6 KOG96959.1 - 0.22 10.5 8.2 0.2 10.6 2.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3987) VID27 PF08553.10 KOG96960.1 - 6.5e-156 518.8 1.1 8.9e-156 518.4 1.1 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 KOG96960.1 - 5.1e-46 156.7 3.3 5.1e-46 156.7 3.3 2.3 2 1 0 2 2 2 1 VID27 N-terminal region VID27_PH PF17747.1 KOG96960.1 - 5e-30 104.0 0.6 4.2e-29 101.0 0.1 2.6 2 1 0 2 2 2 1 VID27 PH-like domain Mrx7 PF10906.8 KOG96961.1 - 1.3e-30 105.4 0.4 1.5e-30 105.2 0.4 1.1 1 0 0 1 1 1 1 MIOREX complex component 7 KH_1 PF00013.29 KOG96962.1 - 1.1e-08 34.7 0.2 1.8e-08 34.0 0.2 1.4 1 0 0 1 1 1 1 KH domain SLS PF14611.6 KOG96962.1 - 0.0068 16.3 0.1 0.012 15.4 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 KOG96962.1 - 0.049 13.5 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 KH domain HSP70 PF00012.20 KOG96963.1 - 6.8e-229 761.0 9.1 7.6e-229 760.9 9.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOG96963.1 - 5.8e-18 64.8 0.4 2e-16 59.7 0.2 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 KOG96963.1 - 0.0044 16.8 0.0 0.0085 15.8 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Zincin_2 PF10103.9 KOG96963.1 - 0.016 14.5 0.0 0.032 13.5 0.0 1.5 1 0 0 1 1 1 0 Zincin-like metallopeptidase FtsA PF14450.6 KOG96963.1 - 0.033 14.6 4.8 3.8 8.0 0.1 3.6 3 2 0 3 3 3 0 Cell division protein FtsA Rick_17kDa_Anti PF05433.15 KOG96964.1 - 1.4e-09 37.6 4.2 1.4e-09 37.6 4.2 2.0 2 0 0 2 2 2 1 Glycine zipper 2TM domain Gly-zipper_YMGG PF13441.6 KOG96964.1 - 0.068 12.9 6.9 5.4 6.8 0.1 2.5 1 1 0 2 2 2 0 YMGG-like Gly-zipper RIO1 PF01163.22 KOG96965.1 - 2.2e-42 144.8 0.2 3.3e-42 144.2 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 KOG96965.1 - 1.9e-31 108.1 0.2 3.6e-31 107.2 0.2 1.5 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 KOG96965.1 - 2.8e-05 24.1 0.3 0.092 12.7 0.9 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KOG96965.1 - 0.0018 17.7 0.1 0.13 11.6 0.1 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 KOG96965.1 - 0.051 12.9 0.1 0.092 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein kinase domain Cwf_Cwc_15 PF04889.12 KOG96965.1 - 3.5 7.3 15.8 5.2 6.7 15.8 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein IFT57 PF10498.9 KOG96965.1 - 9.7 5.0 9.1 14 4.5 9.1 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Nop14 PF04147.12 KOG96965.1 - 9.7 4.3 19.9 13 3.9 19.9 1.1 1 0 0 1 1 1 0 Nop14-like family PH_18 PF18469.1 KOG96966.1 - 4.2e-46 156.4 0.4 4.2e-46 156.4 0.4 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain Rtt106 PF08512.12 KOG96966.1 - 5.9e-30 103.5 0.3 1.7e-29 102.0 0.1 1.9 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Rtt106_N PF18215.1 KOG96966.1 - 1.6e-16 59.8 0.1 3.5e-16 58.7 0.1 1.6 1 0 0 1 1 1 1 Histone chaperone Rtt106 N-terminal domain NOA36 PF06524.12 KOG96966.1 - 3.4 6.9 24.8 6 6.1 24.8 1.3 1 0 0 1 1 1 0 NOA36 protein ArfGap PF01412.18 KOG96967.1 - 1.2e-20 73.8 0.3 2.1e-20 72.9 0.3 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf adh_short_C2 PF13561.6 KOG96968.1 - 2.1e-47 161.7 0.2 2.4e-47 161.4 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOG96968.1 - 4.6e-36 124.1 0.5 5.8e-36 123.8 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOG96968.1 - 4e-10 39.9 0.1 7.5e-10 39.0 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOG96968.1 - 0.0084 15.6 0.0 0.011 15.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 KOG96968.1 - 0.087 12.2 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Shikimate_DH PF01488.20 KOG96968.1 - 0.1 12.7 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase SMK-1 PF04802.15 KOG96969.1 - 1.4e-60 204.4 6.9 1.4e-60 204.4 6.9 2.4 3 0 0 3 3 3 1 Component of IIS longevity pathway SMK-1 YjeF_N PF03853.15 KOG96970.1 - 2.1e-36 125.4 0.0 2.5e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus DUF2335 PF10097.9 KOG96971.1 - 0.024 14.6 0.5 0.069 13.1 0.5 1.7 1 0 0 1 1 1 0 Predicted membrane protein (DUF2335) RRM_1 PF00076.22 KOG96972.1 - 7.5e-18 64.1 0.0 1.3e-16 60.2 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Caldesmon PF02029.15 KOG96972.1 - 1e-05 24.6 22.0 1.3e-05 24.2 22.0 1.2 1 0 0 1 1 1 1 Caldesmon Borrelia_P83 PF05262.11 KOG96972.1 - 0.0013 17.3 24.9 0.0021 16.7 24.9 1.3 1 0 0 1 1 1 1 Borrelia P83/100 protein DREPP PF05558.12 KOG96972.1 - 4.2 7.2 5.6 7.2 6.4 5.6 1.4 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide CDC45 PF02724.14 KOG96972.1 - 7.2 4.8 35.9 14 3.8 35.9 1.4 1 0 0 1 1 1 0 CDC45-like protein SUR7 PF06687.12 KOG96975.1 - 2.2e-37 128.7 16.0 2.8e-37 128.4 16.0 1.1 1 0 0 1 1 1 1 SUR7/PalI family TYA PF01021.19 KOG96975.1 - 0.019 15.3 0.4 0.034 14.5 0.4 1.4 1 0 0 1 1 1 0 TYA transposon protein DUF805 PF05656.14 KOG96975.1 - 0.28 11.6 6.2 0.27 11.7 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF805) DUF1980 PF09323.10 KOG96975.1 - 0.81 9.6 4.5 0.12 12.3 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Fig1 PF12351.8 KOG96975.1 - 3.2 7.7 10.0 6.5 6.6 10.0 1.5 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Anth_Ig PF05587.13 KOG96976.1 - 0.088 13.1 0.1 14 6.1 0.0 2.4 2 0 0 2 2 2 0 Anthrax receptor extracellular domain Chitin_synth_1 PF01644.17 KOG96977.1 - 1.6e-67 226.6 0.0 2.5e-67 225.9 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 KOG96977.1 - 4.6e-25 87.4 0.1 9.9e-25 86.3 0.1 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 KOG96977.1 - 2.4e-16 59.4 10.8 2.1e-12 46.5 0.0 2.7 2 1 0 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.6 KOG96977.1 - 2.1e-10 40.9 4.2 7.4e-10 39.1 4.2 2.1 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 KOG96977.1 - 0.083 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase like family 2 GATase_4 PF13230.6 KOG96978.1 - 1.1e-15 57.3 0.0 5.2e-14 51.8 0.0 2.1 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 KOG96978.1 - 2.9e-11 43.7 0.0 5.2e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KOG96978.1 - 0.062 13.2 0.0 0.17 11.8 0.0 1.7 2 0 0 2 2 2 0 Glutamine amidotransferase domain AKAP2_C PF15304.6 KOG96979.1 - 1.5 8.0 5.9 1.7 7.8 5.9 1.1 1 0 0 1 1 1 0 A-kinase anchor protein 2 C-terminus Arm PF00514.23 KOG96980.1 - 1e-87 285.8 14.0 8.4e-12 44.7 0.1 8.3 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 KOG96980.1 - 4.7e-28 97.5 7.2 1.2e-27 96.1 6.9 1.9 2 0 0 2 2 2 1 Importin beta binding domain Arm_3 PF16186.5 KOG96980.1 - 7.9e-22 76.6 4.0 2.4e-21 75.0 4.0 1.9 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 KOG96980.1 - 1.5e-18 66.9 4.5 8.9e-05 22.9 0.0 7.4 4 3 4 8 8 8 6 HEAT-like repeat HEAT_2 PF13646.6 KOG96980.1 - 2.3e-13 50.3 0.6 0.0032 17.8 0.0 5.2 1 1 5 6 6 6 5 HEAT repeats HEAT PF02985.22 KOG96980.1 - 5.6e-11 41.7 0.0 1.6 9.2 0.0 7.6 7 0 0 7 7 7 1 HEAT repeat Arm_2 PF04826.13 KOG96980.1 - 3.1e-06 26.8 0.5 0.039 13.4 0.0 3.7 3 1 1 4 4 4 2 Armadillo-like V-ATPase_H_C PF11698.8 KOG96980.1 - 8.5e-06 25.9 0.7 0.17 12.0 0.0 4.2 3 3 1 4 4 4 3 V-ATPase subunit H RICTOR_V PF14668.6 KOG96980.1 - 2e-05 24.7 1.5 0.53 10.6 0.0 4.9 3 2 2 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 Adaptin_N PF01602.20 KOG96980.1 - 5e-05 22.1 1.1 0.00044 19.0 1.0 2.8 1 1 0 1 1 1 1 Adaptin N terminal region Atx10homo_assoc PF09759.9 KOG96980.1 - 0.0001 22.2 0.9 0.055 13.5 0.0 4.3 4 1 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain HEAT_PBS PF03130.16 KOG96980.1 - 0.025 15.2 0.8 56 4.8 0.1 4.5 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Cnd1 PF12717.7 KOG96980.1 - 0.031 14.3 2.3 2.1 8.4 0.1 3.0 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 FAST_1 PF06743.15 KOG96980.1 - 0.092 12.7 0.5 1 9.3 0.0 2.8 4 0 0 4 4 4 0 FAST kinase-like protein, subdomain 1 Lactonase PF10282.9 KOG96982.1 - 0.0049 16.2 0.0 0.0081 15.5 0.0 1.3 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller UCH PF00443.29 KOG96983.1 - 7.6e-50 169.8 2.1 7.6e-50 169.8 2.1 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOG96983.1 - 8.2e-17 61.8 2.6 5.4e-15 55.8 2.6 3.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-BED PF02892.15 KOG96983.1 - 0.18 11.9 1.0 17 5.5 0.2 2.8 2 0 0 2 2 2 0 BED zinc finger Ribosomal_L11 PF00298.19 KOG96984.1 - 6.8e-26 90.6 0.3 1.1e-25 89.9 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 KOG96984.1 - 3.6e-25 87.6 0.7 5.9e-25 86.9 0.7 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Pkinase PF00069.25 KOG96985.1 - 1.8e-48 165.3 0.0 3e-48 164.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG96985.1 - 3.6e-23 82.2 0.0 6.2e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOG96985.1 - 0.02 13.9 0.1 0.02 13.9 0.1 2.8 4 0 0 4 4 4 0 Haspin like kinase domain Kinase-like PF14531.6 KOG96985.1 - 0.045 13.1 0.0 0.1 11.9 0.0 1.5 1 1 0 1 1 1 0 Kinase-like FTA2 PF13095.6 KOG96985.1 - 0.052 13.2 0.1 1.8 8.1 0.0 2.3 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KOG96985.1 - 0.2 11.5 0.0 0.32 10.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family ANAPC4_WD40 PF12894.7 KOG96986.1 - 1e-06 28.9 0.4 0.00045 20.5 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOG96986.1 - 0.00083 20.1 0.3 1.5 9.8 0.0 4.4 4 0 0 4 4 4 1 WD domain, G-beta repeat HPS3_N PF14761.6 KOG96986.1 - 0.0077 15.8 1.1 0.078 12.5 0.3 2.7 2 1 0 2 2 2 1 Hermansky-Pudlak syndrome 3 AP1AR PF15745.5 KOG96986.1 - 0.022 14.4 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein CBM_19 PF03427.13 KOG96986.1 - 0.11 12.6 3.8 0.22 11.5 1.0 2.7 3 0 0 3 3 3 0 Carbohydrate binding domain (family 19) adh_short PF00106.25 KOG96987.1 - 1.3e-08 34.5 0.0 2e-07 30.7 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 KOG96987.1 - 1.9e-05 24.6 0.0 3.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 KOG96987.1 - 0.00013 21.6 0.0 0.00024 20.7 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ras PF00071.22 KOG96988.1 - 7.6e-45 152.4 0.1 6.5e-43 146.1 0.1 2.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KOG96988.1 - 2.2e-18 66.6 1.0 8.7e-10 38.9 0.0 3.5 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG96988.1 - 4.3e-06 26.3 0.0 0.017 14.6 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOG96988.1 - 7.4e-06 25.6 0.5 0.00012 21.7 0.0 2.7 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain Ribosomal_S3_C PF00189.20 KOG96989.1 - 6.3e-23 81.1 0.5 3.3e-22 78.8 0.6 2.0 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 KOG96989.1 - 6e-12 45.2 0.0 2.8e-11 43.1 0.1 2.0 2 0 0 2 2 2 1 KH domain Ribosomal_L22 PF00237.19 KOG96990.1 - 2.2e-19 69.6 0.0 4.4e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Syndecan PF01034.20 KOG96991.1 - 0.24 11.3 0.0 0.47 10.4 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain RRM_1 PF00076.22 KOG96992.1 - 1.2e-24 85.8 5.1 6.6e-17 61.1 0.1 4.1 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOG96992.1 - 4.8e-05 23.4 0.6 0.15 12.2 0.0 3.1 2 2 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 KOG96992.1 - 0.034 14.1 0.0 0.073 13.1 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif GNAT_acetyltr_2 PF13718.6 KOG96992.1 - 0.19 11.1 2.2 1.2 8.5 1.1 2.4 2 1 0 2 2 2 0 GNAT acetyltransferase 2 AMPK1_CBM PF16561.5 KOG96993.1 - 2.5e-12 46.8 0.1 5.2e-12 45.8 0.1 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase FAM176 PF14851.6 KOG96993.1 - 4.1 7.1 13.1 3.6 7.3 0.8 2.3 2 0 0 2 2 2 0 FAM176 family E7 PF00527.18 KOG96993.1 - 4.4 7.6 10.0 11 6.3 0.6 2.5 2 0 0 2 2 2 0 E7 protein, Early protein ANAPC1 PF12859.7 KOG96994.1 - 1.8e-05 25.3 3.7 0.0002 21.9 3.7 2.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 KOG96994.1 - 8.2 7.1 11.7 29 5.3 0.0 4.6 4 0 0 4 4 4 0 Proteasome/cyclosome repeat PS_Dcarbxylase PF02666.15 KOG96995.1 - 3.1e-68 229.3 0.0 4.5e-68 228.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase NADH_oxidored PF08040.11 KOG96995.1 - 0.0031 17.2 0.0 0.0082 15.8 0.0 1.7 1 0 0 1 1 1 1 MNLL subunit Biotin_lipoyl PF00364.22 KOG96995.1 - 0.032 14.1 0.7 0.39 10.6 0.0 2.3 2 0 0 2 2 2 0 Biotin-requiring enzyme FAA_hydrolase PF01557.18 KOG96996.1 - 9.3e-50 169.3 0.0 1.2e-49 169.0 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family bZIP_1 PF00170.21 KOG96997.1 - 4.5e-07 29.9 1.5 4.5e-07 29.9 1.5 1.9 2 0 0 2 2 2 1 bZIP transcription factor Aft1_OSA PF11785.8 KOG96997.1 - 1.1e-05 25.7 0.8 1.1e-05 25.7 0.8 2.7 2 0 0 2 2 2 1 Aft1 osmotic stress response (OSM) domain bZIP_2 PF07716.15 KOG96997.1 - 0.00013 22.0 3.8 0.00013 22.0 3.8 1.8 2 0 0 2 2 2 1 Basic region leucine zipper ATP13 PF12921.7 KOG96997.1 - 0.0012 18.7 0.9 0.003 17.4 0.1 2.1 2 0 0 2 2 2 1 Mitochondrial ATPase expression HtaA PF04213.13 KOG97000.1 - 0.041 14.4 0.3 0.13 12.8 0.0 1.8 2 0 0 2 2 2 0 Htaa GTP_EFTU PF00009.27 KOG97001.1 - 2.1e-58 197.1 0.0 3.4e-58 196.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 KOG97001.1 - 1.8e-13 50.3 0.1 6.8e-13 48.5 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOG97001.1 - 3.1e-11 43.5 0.0 7.5e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 KOG97001.1 - 1.1e-08 35.0 0.0 2.6e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 KOG97001.1 - 0.00071 19.3 0.0 0.003 17.4 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 KOG97001.1 - 0.0084 16.2 0.0 0.026 14.6 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase zf-C2H2 PF00096.26 KOG97002.1 - 0.12 12.9 1.6 3.4 8.3 0.0 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type Ribosomal_L44 PF00935.19 KOG97003.1 - 2.1e-35 121.0 12.5 3.2e-35 120.4 12.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 Pkinase PF00069.25 KOG97004.1 - 5.6e-59 199.7 0.3 6.8e-42 143.6 0.2 3.4 3 0 0 3 3 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97004.1 - 1.8e-24 86.5 0.3 1.2e-20 74.0 0.0 3.1 3 0 0 3 3 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOG97004.1 - 0.0045 15.8 17.2 0.18 10.5 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase Seadorna_VP7 PF07387.11 KOG97004.1 - 0.028 13.5 0.0 0.049 12.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Mem_trans PF03547.18 KOG97004.1 - 0.37 9.2 2.1 0.5 8.7 2.1 1.4 1 0 0 1 1 1 0 Membrane transport protein CDC45 PF02724.14 KOG97004.1 - 0.68 8.1 27.9 1.3 7.2 27.9 1.3 1 0 0 1 1 1 0 CDC45-like protein LMBR1 PF04791.16 KOG97004.1 - 1.1 8.1 12.9 1.8 7.4 12.9 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein RR_TM4-6 PF06459.12 KOG97004.1 - 1.1 9.0 31.4 0.44 10.3 27.9 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 KOG97004.1 - 1.4 7.7 21.8 3.7 6.3 21.8 1.9 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4746 PF15928.5 KOG97004.1 - 1.7 8.0 19.1 0.41 10.0 15.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Draxin PF15550.6 KOG97004.1 - 2.9 7.7 21.6 9.4 6.0 21.6 2.0 1 0 0 1 1 1 0 Draxin Tim54 PF11711.8 KOG97004.1 - 3.7 6.2 29.3 8 5.1 29.3 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Membralin PF09746.9 KOG97004.1 - 4.3 6.3 20.6 9.5 5.1 20.6 1.7 1 0 0 1 1 1 0 Tumour-associated protein Paramyxo_ncap PF00973.19 KOG97004.1 - 4.4 6.1 20.2 7.7 5.3 20.2 1.4 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Otopetrin PF03189.13 KOG97004.1 - 5.5 5.7 13.7 10 4.8 13.7 1.5 1 0 0 1 1 1 0 Otopetrin CLN3 PF02487.17 KOG97004.1 - 6.4 5.7 18.8 19 4.2 18.8 1.9 1 0 0 1 1 1 0 CLN3 protein APH PF01636.23 KOG97004.1 - 6.7 6.6 17.2 0.82 9.5 0.1 3.3 2 1 1 3 3 2 0 Phosphotransferase enzyme family AAA_23 PF13476.6 KOG97004.1 - 6.9 7.1 44.4 7.1 7.1 36.3 2.7 2 0 0 2 2 2 0 AAA domain Hamartin PF04388.12 KOG97004.1 - 7 5.2 36.1 13 4.3 36.1 1.4 1 0 0 1 1 1 0 Hamartin protein Asparaginase PF00710.20 KOG97005.1 - 0.00015 21.3 0.8 0.0021 17.7 0.1 2.3 1 1 1 2 2 2 1 Asparaginase, N-terminal Pga1 PF10333.9 KOG97007.1 - 1.9e-58 197.2 1.0 2.2e-58 197.0 1.0 1.0 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Endosulfine PF04667.17 KOG97008.1 - 1.2e-28 99.1 0.3 2e-28 98.3 0.3 1.4 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region INSIG PF07281.12 KOG97009.1 - 1.5e-19 70.6 2.8 8.6e-18 64.8 0.4 2.3 1 1 1 2 2 2 2 Insulin-induced protein (INSIG) zf-AN1 PF01428.16 KOG97010.1 - 1.7e-11 44.0 13.2 2.9e-11 43.3 13.2 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger RE_NgoBV PF09564.10 KOG97010.1 - 0.027 13.9 0.1 0.04 13.3 0.1 1.2 1 0 0 1 1 1 0 NgoBV restriction endonuclease PSI_integrin PF17205.3 KOG97010.1 - 1 9.2 7.1 14 5.5 7.1 2.5 1 1 0 1 1 1 0 Integrin plexin domain DHHC PF01529.20 KOG97010.1 - 6.9 6.8 9.2 17 5.5 8.9 1.8 2 0 0 2 2 2 0 DHHC palmitoyltransferase Pkinase PF00069.25 KOG97011.1 - 1.5e-24 86.8 0.0 1.5e-24 86.8 0.0 2.0 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97011.1 - 2.3e-12 46.8 0.7 4.3e-12 45.9 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOG97011.1 - 1.1e-09 37.6 0.0 1.1e-09 37.6 0.0 2.5 2 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KOG97011.1 - 0.0001 22.3 4.4 0.39 10.6 0.8 3.2 2 1 1 3 3 3 2 Phosphotransferase enzyme family Prefoldin_2 PF01920.20 KOG97012.1 - 1.9e-22 79.2 8.5 2.3e-22 79.0 8.5 1.1 1 0 0 1 1 1 1 Prefoldin subunit SMK-1 PF04802.15 KOG97012.1 - 0.02 14.7 2.5 0.025 14.4 2.5 1.1 1 0 0 1 1 1 0 Component of IIS longevity pathway SMK-1 FAM167 PF11652.8 KOG97012.1 - 1.9 9.1 5.1 19 5.9 0.4 2.4 1 1 1 2 2 2 0 FAM167 Seryl_tRNA_N PF02403.22 KOG97012.1 - 2.1 8.6 9.2 3.9 7.7 1.3 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4140 PF13600.6 KOG97012.1 - 2.4 8.6 5.2 0.66 10.5 0.6 1.9 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) C2 PF00168.30 KOG97013.1 - 1.7e-07 31.4 0.0 3.7e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 C2 domain Cnn_1N PF07989.11 KOG97013.1 - 0.15 12.3 0.9 1 9.5 0.0 2.5 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 RNA_pol_3_Rpc31 PF11705.8 KOG97014.1 - 6.7e-54 183.5 7.7 8.4e-54 183.2 7.7 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 DUF4820 PF16091.5 KOG97014.1 - 7 6.0 8.6 14 4.9 4.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) PGA2 PF07543.12 KOG97015.1 - 3.3e-11 43.3 11.4 4.3e-08 33.2 11.4 2.1 1 1 0 1 1 1 1 Protein trafficking PGA2 Imm30 PF15565.6 KOG97015.1 - 0.015 15.4 1.0 2.7 8.1 0.1 2.4 2 0 0 2 2 2 0 Immunity protein 30 Tmemb_9 PF05434.11 KOG97015.1 - 0.033 14.1 0.3 0.044 13.7 0.3 1.2 1 0 0 1 1 1 0 TMEM9 TMEM208_SND2 PF05620.11 KOG97015.1 - 0.13 12.1 0.0 0.13 12.1 0.0 1.5 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 UPF0542 PF15086.6 KOG97015.1 - 0.25 11.3 0.1 0.25 11.3 0.1 2.0 2 1 0 2 2 2 0 Uncharacterised protein family UPF0542 SieB PF14163.6 KOG97015.1 - 0.28 10.6 1.1 0.31 10.5 0.0 1.6 2 0 0 2 2 2 0 Super-infection exclusion protein B OAD_gamma PF04277.13 KOG97015.1 - 0.33 11.6 1.3 1.5 9.5 1.3 1.9 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain VPS11_C PF12451.8 KOG97015.1 - 5 7.4 7.4 0.46 10.8 2.2 1.9 2 1 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal MscS_TM PF12794.7 KOG97015.1 - 8.5 5.1 5.4 25 3.6 5.4 1.8 1 1 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 CAP_GLY PF01302.25 KOG97016.1 - 2.2e-14 53.2 0.0 3.7e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 KOG97016.1 - 8.6e-12 45.4 0.1 1.2e-11 44.9 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain LSM PF01423.22 KOG97017.1 - 1.1e-18 66.7 0.6 1.4e-18 66.3 0.6 1.2 1 0 0 1 1 1 1 LSM domain MFA1_2 PF17317.2 KOG97019.1 - 3.1e-23 81.2 0.5 3.5e-23 81.1 0.5 1.0 1 0 0 1 1 1 1 Mating hormone A-factor 1&2 LOR PF04525.12 KOG97019.1 - 0.031 13.9 0.0 0.031 13.9 0.0 1.0 1 0 0 1 1 1 0 LURP-one-related Ammonium_transp PF00909.21 KOG97021.1 - 3.6e-128 427.7 30.9 4.1e-128 427.5 30.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family A_deaminase PF00962.22 KOG97022.1 - 1.7e-101 339.9 0.0 1.9e-101 339.7 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase TRM PF02005.16 KOG97022.1 - 0.025 13.8 0.0 0.037 13.2 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase THOC2_N PF16134.5 KOG97023.1 - 4.6e-177 590.5 13.1 8.5e-177 589.6 13.1 1.5 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 KOG97023.1 - 1e-42 146.4 8.9 3.6e-30 105.2 3.7 4.0 4 1 1 5 5 5 2 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 KOG97023.1 - 6.8e-23 80.5 0.3 2e-22 79.0 0.3 1.9 1 0 0 1 1 1 1 Transcription- and export-related complex subunit CAP_N PF01213.19 KOG97025.1 - 1.1e-109 366.7 2.1 1.1e-109 366.7 2.1 1.5 1 1 1 2 2 2 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 KOG97025.1 - 4.5e-61 205.0 2.0 8.8e-61 204.1 1.2 1.8 2 0 0 2 2 2 1 Adenylate cyclase associated (CAP) C terminal S4 PF01479.25 KOG97026.1 - 3.1e-16 58.8 0.0 5.8e-16 57.9 0.0 1.5 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 KOG97026.1 - 0.0066 16.2 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 S4 domain Tox-REase-9 PF15650.6 KOG97026.1 - 0.01 16.1 1.2 0.03 14.6 0.0 2.4 3 0 0 3 3 3 0 Restriction endonuclease fold toxin 9 Eaf7 PF07904.13 KOG97027.1 - 5.3e-36 123.2 0.7 5.3e-36 123.2 0.7 4.0 2 1 0 2 2 2 1 Chromatin modification-related protein EAF7 FKBP_C PF00254.28 KOG97028.1 - 1.4e-33 115.0 0.0 1.7e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase ADH_zinc_N PF00107.26 KOG97029.1 - 1.2e-10 41.5 0.0 2e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOG97029.1 - 0.045 13.6 0.1 0.15 12.0 0.1 1.8 1 1 1 2 2 2 0 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 KOG97029.1 - 0.078 14.0 0.0 0.13 13.3 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Nefa_Nip30_N PF10187.9 KOG97030.1 - 1.9e-06 28.2 14.1 3.1e-06 27.5 14.1 1.4 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 CSRNP_N PF16019.5 KOG97030.1 - 0.79 9.6 5.6 1 9.3 5.6 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus GNAT_acetyltr_2 PF13718.6 KOG97031.1 - 3.3e-99 330.9 2.8 4.3e-99 330.5 0.0 2.6 3 0 0 3 3 3 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 KOG97031.1 - 8.9e-93 310.3 9.9 1.8e-92 309.3 9.9 1.5 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 KOG97031.1 - 1.4e-64 217.2 0.1 5.9e-64 215.2 0.0 2.2 2 1 0 2 2 2 1 Helicase DUF1726 PF08351.11 KOG97031.1 - 6.8e-34 115.7 0.2 2.2e-33 114.0 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_22 PF13401.6 KOG97031.1 - 0.0082 16.4 0.0 0.88 9.8 0.0 2.9 2 0 0 2 2 2 1 AAA domain Tom22 PF04281.13 KOG97032.1 - 1.9e-48 163.8 1.0 2.2e-48 163.6 1.0 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 CDP-OH_P_transf PF01066.21 KOG97033.1 - 3.4e-16 59.7 0.1 3.4e-16 59.7 0.1 3.3 3 2 0 3 3 3 1 CDP-alcohol phosphatidyltransferase COX2-transmemb PF09125.10 KOG97033.1 - 0.1 12.4 1.3 1.7 8.5 1.1 3.0 1 1 1 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane PRK PF00485.18 KOG97034.1 - 1.4e-06 28.2 0.1 2.4e-06 27.4 0.1 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 KOG97034.1 - 1.5e-06 28.8 0.1 4.5e-06 27.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 KOG97034.1 - 0.00099 18.9 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase CPT PF07931.12 KOG97034.1 - 0.0091 15.9 0.4 0.053 13.4 0.4 2.3 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein tRNA_lig_kinase PF08303.11 KOG97034.1 - 0.014 15.5 0.2 0.096 12.8 0.0 2.1 2 0 0 2 2 2 0 tRNA ligase kinase domain Spermine_synth PF01564.17 KOG97034.1 - 0.061 12.7 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Spermine/spermidine synthase domain AAA_33 PF13671.6 KOG97034.1 - 0.062 13.5 0.0 0.1 12.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KOG97034.1 - 0.078 13.2 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOG97034.1 - 0.12 12.6 0.0 0.31 11.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain DSPc PF00782.20 KOG97035.1 - 6.3e-09 35.8 0.0 1.3e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KOG97035.1 - 0.0033 17.6 0.0 0.012 15.8 0.0 1.9 2 0 0 2 2 2 1 Inositol hexakisphosphate DUF3836 PF12930.7 KOG97035.1 - 0.017 14.8 0.2 0.038 13.8 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF3836) Y_phosphatase3 PF13350.6 KOG97035.1 - 0.026 14.5 0.0 0.05 13.6 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 KOG97035.1 - 0.069 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase N1221 PF07923.13 KOG97036.1 - 1.8e-70 237.4 3.0 3.3e-70 236.6 3.0 1.4 1 0 0 1 1 1 1 N1221-like protein DUF3402 PF11882.8 KOG97036.1 - 5.5e-52 177.4 25.6 3.3e-29 102.3 6.0 4.1 2 1 1 3 3 3 2 Domain of unknown function (DUF3402) DUF2457 PF10446.9 KOG97036.1 - 5 6.1 24.8 9.2 5.3 24.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) GCP_N_terminal PF17681.1 KOG97037.1 - 9e-34 117.5 1.4 9e-34 117.5 1.4 2.5 2 1 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 KOG97037.1 - 5.9e-30 104.8 4.8 9.1e-30 104.2 2.7 2.2 3 0 0 3 3 3 1 Gamma tubulin complex component C-terminal MFS_1 PF07690.16 KOG97038.1 - 4.1e-28 98.3 63.2 1.1e-21 77.2 42.2 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG97038.1 - 2.6e-06 26.6 20.3 7.8e-06 25.0 0.9 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 KOG97038.1 - 4e-05 22.6 12.0 0.012 14.5 2.7 2.3 2 0 0 2 2 2 2 MFS_1 like family Gar1 PF04410.14 KOG97039.1 - 9.7e-43 145.6 0.0 9.7e-43 145.6 0.0 2.7 3 0 0 3 3 3 1 Gar1/Naf1 RNA binding region PA26 PF04636.13 KOG97039.1 - 0.59 9.0 9.5 0.18 10.7 0.9 2.2 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) DUF4632 PF15451.6 KOG97039.1 - 3.5 7.8 7.4 19 5.4 7.4 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) PDZ_1 PF12812.7 KOG97040.1 - 2.9e-54 181.0 0.2 4.1e-37 126.0 0.0 3.1 3 0 0 3 3 3 2 PDZ-like domain Trypsin_2 PF13365.6 KOG97040.1 - 5.3e-25 89.1 0.2 4.7e-20 73.0 0.0 2.5 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_6 PF17820.1 KOG97040.1 - 1.2e-11 44.3 2.0 5.4e-05 23.0 0.3 4.8 5 0 0 5 5 5 2 PDZ domain PDZ PF00595.24 KOG97040.1 - 1.2e-11 44.8 0.5 2.7e-08 34.0 0.0 2.9 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 KOG97040.1 - 7.3e-11 42.2 2.3 0.0019 18.5 0.1 4.2 4 0 0 4 4 4 2 PDZ domain Trypsin PF00089.26 KOG97040.1 - 0.0012 18.8 0.0 0.0033 17.3 0.0 1.7 1 1 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.6 KOG97040.1 - 0.0022 17.9 0.5 1.2 9.1 0.2 3.3 3 0 0 3 3 3 1 Tricorn protease PDZ domain DUF31 PF01732.16 KOG97040.1 - 0.014 15.0 0.1 0.022 14.3 0.1 1.3 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S7 PF00949.21 KOG97040.1 - 0.16 11.8 0.1 0.38 10.6 0.1 1.5 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Ribosomal_L35p PF01632.19 KOG97041.1 - 1.2e-11 44.9 8.4 1.8e-11 44.3 8.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L35 TPR_2 PF07719.17 KOG97042.1 - 5.4e-26 88.6 23.2 9.3e-05 22.3 0.0 11.6 10 1 1 11 11 11 5 Tetratricopeptide repeat TPR_1 PF00515.28 KOG97042.1 - 4.5e-25 86.4 30.9 4.6e-07 29.4 3.1 11.1 10 1 1 11 11 11 5 Tetratricopeptide repeat TPR_16 PF13432.6 KOG97042.1 - 3.8e-20 72.2 0.5 0.0062 17.2 0.0 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOG97042.1 - 4.2e-18 65.4 7.8 0.0066 16.7 0.6 7.5 6 3 1 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 KOG97042.1 - 1.1e-15 57.0 6.7 0.094 13.6 0.0 9.5 5 3 5 10 10 10 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOG97042.1 - 9.1e-15 53.6 33.6 0.00094 19.2 0.0 10.7 12 0 0 12 12 10 5 Tetratricopeptide repeat TPR_19 PF14559.6 KOG97042.1 - 8.2e-14 51.9 11.6 5.6e-05 23.6 1.3 7.2 4 3 3 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOG97042.1 - 2.8e-13 49.3 18.5 0.0044 16.7 0.3 7.6 5 2 2 7 7 7 4 TPR repeat TPR_7 PF13176.6 KOG97042.1 - 3.1e-09 36.2 8.0 1.6 8.9 0.2 7.1 7 0 0 7 7 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOG97042.1 - 3.7e-08 33.5 9.9 0.0079 16.4 0.0 5.1 3 2 2 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 KOG97042.1 - 6.6e-06 26.2 0.0 0.3 11.3 0.0 4.8 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOG97042.1 - 1.5e-05 25.1 17.5 2 9.0 0.0 8.6 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KOG97042.1 - 2.8e-05 23.7 0.0 0.39 10.0 1.5 3.5 2 1 1 3 3 3 2 MalT-like TPR region HrpB1_HrpK PF09613.10 KOG97042.1 - 0.00013 21.6 0.1 0.26 10.9 0.2 3.4 4 0 0 4 4 4 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_10 PF13374.6 KOG97042.1 - 0.0028 17.5 4.2 4.2 7.4 0.1 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat Exonuc_VII_S PF02609.16 KOG97042.1 - 0.0038 17.3 3.2 0.016 15.2 0.9 3.2 2 0 0 2 2 2 1 Exonuclease VII small subunit TPR_21 PF09976.9 KOG97042.1 - 0.025 14.3 16.0 0.14 11.8 1.2 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat-like domain SCIMP PF15050.6 KOG97042.1 - 0.026 15.0 0.1 0.076 13.5 0.1 1.8 1 0 0 1 1 1 0 SCIMP protein SHNi-TPR PF10516.9 KOG97042.1 - 0.17 11.4 4.0 10 5.7 0.1 4.1 3 0 0 3 3 3 0 SHNi-TPR MIT PF04212.18 KOG97042.1 - 0.26 11.4 12.6 16 5.6 1.6 5.7 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain PPR PF01535.20 KOG97042.1 - 0.3 11.4 7.3 1.7e+02 2.8 0.1 6.2 6 0 0 6 6 6 0 PPR repeat DUF3808 PF10300.9 KOG97042.1 - 0.63 8.7 10.7 0.43 9.3 0.3 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF3808) PPR_2 PF13041.6 KOG97042.1 - 2.1 8.6 4.7 90 3.4 0.1 4.7 5 0 0 5 5 5 0 PPR repeat family U1snRNP70_N PF12220.8 KOG97042.1 - 3.3 8.4 10.3 11 6.8 3.2 3.3 2 1 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal MAS20 PF02064.15 KOG97042.1 - 7.7 6.6 14.6 0.24 11.5 5.2 2.8 3 0 0 3 3 2 0 MAS20 protein import receptor TPR_6 PF13174.6 KOG97042.1 - 7.9 7.4 18.9 42 5.1 0.2 7.7 9 0 0 9 9 7 0 Tetratricopeptide repeat CTU2 PF10288.9 KOG97043.1 - 2e-22 79.5 2.0 5.6e-22 78.1 2.0 1.8 1 0 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 Phage_int_SAM_3 PF14659.6 KOG97043.1 - 0.031 14.5 0.9 0.1 12.9 0.9 2.0 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain GFA PF04828.14 KOG97043.1 - 0.11 12.9 1.1 15 6.0 0.0 2.9 3 0 0 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme DCP2 PF05026.13 KOG97044.1 - 1.2e-26 92.9 1.0 2.8e-26 91.6 1.0 1.7 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 KOG97044.1 - 2.5e-13 50.2 0.0 5.4e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain MRP_L53 PF10780.9 KOG97044.1 - 0.4 10.9 5.2 58 4.0 0.0 4.9 4 0 0 4 4 4 0 39S ribosomal protein L53/MRP-L53 Malate_synthase PF01274.22 KOG97045.1 - 8.5e-226 750.3 0.0 9.7e-226 750.1 0.0 1.0 1 0 0 1 1 1 1 Malate synthase FHA PF00498.26 KOG97046.1 - 3.8e-15 56.0 0.1 8.6e-15 54.9 0.1 1.7 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 KOG97046.1 - 9e-10 38.1 10.9 1.8e-09 37.2 10.9 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 KOG97046.1 - 1.8e-05 25.0 13.5 3.1e-05 24.2 13.5 1.4 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 KOG97046.1 - 0.0011 19.2 0.0 0.0028 17.9 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-ANAPC11 PF12861.7 KOG97046.1 - 0.026 14.6 3.3 0.054 13.5 3.3 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 KOG97046.1 - 0.034 14.1 10.7 0.057 13.4 10.7 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 KOG97046.1 - 0.068 13.0 12.9 0.13 12.2 12.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Sec_GG PF07549.14 KOG97046.1 - 0.09 12.3 0.2 0.18 11.3 0.2 1.5 1 0 0 1 1 1 0 SecD/SecF GG Motif zf-C3HC4_2 PF13923.6 KOG97046.1 - 0.21 11.4 12.7 0.46 10.4 12.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOG97046.1 - 0.32 11.3 8.4 0.93 9.8 8.4 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain TFIIA PF03153.13 KOG97046.1 - 1.4 8.8 20.1 2.8 7.8 20.1 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med26_C PF15693.5 KOG97046.1 - 2.1 8.5 8.7 0.91 9.7 1.8 2.7 3 0 0 3 3 3 0 Mediator complex subunit 26 C-terminal zf-RING_UBOX PF13445.6 KOG97046.1 - 8.4 6.5 11.5 18 5.5 11.5 1.6 1 0 0 1 1 1 0 RING-type zinc-finger DUF2417 PF10329.9 KOG97047.1 - 7.4e-80 267.8 8.7 9.7e-80 267.4 8.7 1.1 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_1 PF00561.20 KOG97047.1 - 5.6e-26 91.7 0.0 7.8e-26 91.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOG97047.1 - 0.0062 17.2 0.2 0.0096 16.5 0.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family RNA_pol_L_2 PF13656.6 KOG97048.1 - 4.9e-34 115.9 0.0 8.1e-34 115.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 KOG97048.1 - 2.5e-15 55.6 0.0 3.7e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Cyt-b5 PF00173.28 KOG97049.1 - 1.4e-24 86.0 0.1 1.8e-24 85.7 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain RRM_1 PF00076.22 KOG97050.1 - 5.1e-17 61.4 0.0 1.2e-16 60.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2129 PF09902.9 KOG97050.1 - 0.23 11.6 5.9 2.7 8.1 0.1 3.9 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2129) His_Phos_1 PF00300.22 KOG97051.1 - 1.4e-18 67.3 0.0 2e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) YEATS PF03366.16 KOG97052.1 - 7.6e-35 118.7 0.2 1.3e-34 118.0 0.2 1.4 1 0 0 1 1 1 1 YEATS family GPS2_interact PF15784.5 KOG97052.1 - 0.012 16.0 1.0 0.012 16.0 1.0 1.9 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain Osmo_CC PF08946.10 KOG97052.1 - 0.16 12.3 6.0 0.35 11.2 6.0 1.5 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Syja_N PF02383.18 KOG97053.1 - 3.7e-77 259.8 0.7 6.2e-77 259.0 0.7 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 KOG97053.1 - 2.2e-16 60.1 0.1 3.4e-16 59.5 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HMGL-like PF00682.19 KOG97054.1 - 3.5e-92 308.7 0.0 5.1e-92 308.2 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 KOG97054.1 - 9.2e-26 90.3 0.5 1.8e-25 89.4 0.5 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain CGI-121 PF08617.10 KOG97054.1 - 0.078 13.1 0.0 0.46 10.6 0.0 2.0 2 0 0 2 2 2 0 Kinase binding protein CGI-121 bZIP_2 PF07716.15 KOG97055.1 - 0.0021 18.1 3.1 0.0021 18.1 3.1 2.4 2 0 0 2 2 2 1 Basic region leucine zipper PspB PF06667.12 KOG97055.1 - 0.021 14.9 3.6 0.024 14.7 2.1 1.9 1 1 1 2 2 2 0 Phage shock protein B IL1_propep PF02394.16 KOG97055.1 - 8.9 7.3 8.9 2 9.4 3.1 2.9 2 0 0 2 2 2 0 Interleukin-1 propeptide DNA_pol_B PF00136.21 KOG97056.1 - 6.5e-125 417.4 0.5 9.8e-125 416.8 0.5 1.3 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 KOG97056.1 - 1.7e-63 213.7 3.9 3.8e-63 212.6 3.9 1.6 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 KOG97056.1 - 9.7e-58 195.9 0.0 1.9e-57 194.9 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 KOG97056.1 - 1.7e-18 66.5 10.7 7.3e-18 64.4 10.7 2.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal Aa_trans PF01490.18 KOG97057.1 - 2.9e-108 362.2 37.0 3.5e-108 362.0 37.0 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ApoO PF09769.9 KOG97058.1 - 4.9e-05 23.3 0.4 1.2 9.1 0.0 3.4 3 1 0 3 3 3 3 Apolipoprotein O Y_phosphatase2 PF03162.13 KOG97059.1 - 4.3e-60 202.0 0.0 5.7e-60 201.6 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 KOG97059.1 - 1.7e-05 24.9 0.0 4.5e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 KOG97059.1 - 0.019 14.8 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOG97059.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Ras PF00071.22 KOG97060.1 - 8.2e-57 191.3 0.3 1.2e-56 190.8 0.3 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG97060.1 - 5.9e-20 71.7 0.0 1.4e-19 70.5 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG97060.1 - 2.6e-10 40.0 0.1 3.9e-10 39.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOG97060.1 - 3.8e-05 23.3 1.2 0.00011 21.8 0.2 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KOG97060.1 - 9.1e-05 22.4 2.2 0.082 12.8 0.1 2.5 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KOG97060.1 - 0.00043 20.3 0.0 0.0011 19.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 KOG97060.1 - 0.06 13.4 0.7 0.2 11.7 0.2 1.9 1 1 0 2 2 2 0 C-terminal region of MMR_HSR1 domain ATP_bind_1 PF03029.17 KOG97060.1 - 0.42 10.4 3.6 1.3 8.8 0.2 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein ING PF12998.7 KOG97061.1 - 5.8e-24 84.6 0.9 5.8e-24 84.6 0.9 1.7 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 KOG97061.1 - 4.8e-05 23.2 7.5 8.3e-05 22.4 7.5 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 KOG97061.1 - 0.014 14.9 1.4 0.029 13.9 1.4 1.5 1 0 0 1 1 1 0 PHD-finger Elongin_A PF06881.11 KOG97061.1 - 0.031 14.8 1.8 0.033 14.7 0.1 1.8 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A zf-HC5HC2H PF13771.6 KOG97061.1 - 0.14 12.4 0.9 0.37 11.1 0.9 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain Macoilin PF09726.9 KOG97061.1 - 1.3 7.4 9.4 1.6 7.2 9.4 1.1 1 0 0 1 1 1 0 Macoilin family Ribosomal_S7e PF01251.18 KOG97062.1 - 1.5e-79 266.0 2.5 1.9e-79 265.8 2.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e DUF2345 PF10106.9 KOG97062.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2345) Mem_trans PF03547.18 KOG97063.1 - 1.1e-27 96.4 0.0 2.5e-27 95.3 0.0 1.5 1 1 0 1 1 1 1 Membrane transport protein DUF2183 PF09949.9 KOG97064.1 - 2e-31 108.3 0.1 6e-31 106.7 0.1 1.9 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.13 KOG97064.1 - 0.017 14.6 0.1 0.067 12.7 0.1 1.9 2 0 0 2 2 2 0 LNS2 (Lipin/Ned1/Smp2) Mito_fiss_reg PF05308.11 KOG97064.1 - 0.69 10.0 8.3 0.41 10.7 5.3 2.1 2 0 0 2 2 2 0 Mitochondrial fission regulator Ras PF00071.22 KOG97065.1 - 5.6e-56 188.6 0.1 6.7e-56 188.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG97065.1 - 1.3e-35 122.2 0.0 2.1e-35 121.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG97065.1 - 1e-17 64.2 0.0 1.2e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOG97065.1 - 8.8e-08 31.8 0.0 1.1e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOG97065.1 - 4e-06 26.9 0.0 7.4e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOG97065.1 - 1.3e-05 24.8 0.0 1.7e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KOG97065.1 - 6.3e-05 22.9 0.8 0.2 11.5 0.1 2.1 1 1 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 KOG97065.1 - 0.0024 18.3 0.0 0.003 18.0 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain G-alpha PF00503.20 KOG97065.1 - 0.094 11.9 0.8 19 4.3 0.1 2.7 1 1 1 2 2 2 0 G-protein alpha subunit TniB PF05621.11 KOG97065.1 - 0.12 11.7 0.0 0.32 10.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein N2227 PF07942.12 KOG97066.1 - 1.2e-93 313.2 0.0 2.2e-93 312.4 0.0 1.4 2 0 0 2 2 2 1 N2227-like protein Methyltransf_11 PF08241.12 KOG97066.1 - 0.00031 21.3 0.0 0.048 14.3 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOG97066.1 - 0.004 17.0 0.0 0.0097 15.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOG97066.1 - 0.044 14.5 0.0 4.7 8.0 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 KOG97066.1 - 0.068 13.9 0.1 0.24 12.1 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.18 KOG97066.1 - 0.17 11.2 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family NST1 PF13945.6 KOG97067.1 - 5.4e-12 46.2 6.5 5.4e-12 46.2 6.5 5.5 5 2 1 6 6 6 1 Salt tolerance down-regulator Ras PF00071.22 KOG97068.1 - 2.3e-51 173.6 0.0 2.7e-51 173.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG97068.1 - 2.9e-22 79.1 0.0 3.9e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG97068.1 - 1.7e-08 34.1 0.0 2.5e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 KOG97068.1 - 0.0043 16.8 0.0 3.6 7.3 0.0 2.5 3 0 0 3 3 3 2 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 KOG97068.1 - 0.03 13.7 0.0 0.044 13.2 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_21 PF13304.6 KOG97068.1 - 0.063 13.1 0.0 0.074 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF4930 PF16284.5 KOG97068.1 - 0.19 11.7 0.0 0.27 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4930) DNA_topoisoIV PF00521.20 KOG97069.1 - 7.3e-123 410.6 0.6 1.3e-122 409.8 0.0 1.7 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 KOG97069.1 - 1.1e-48 164.7 1.2 4.1e-48 162.9 1.2 2.1 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 KOG97069.1 - 1.2e-24 86.8 1.8 2.4e-24 85.8 1.8 1.5 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 KOG97069.1 - 7.2e-15 55.5 0.1 3.4e-14 53.3 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 KOG97069.1 - 5.3e-07 29.8 0.0 2.4e-06 27.7 0.0 2.1 1 0 0 1 1 1 1 Toprim domain C2 PF00168.30 KOG97070.1 - 4e-49 165.2 9.6 2.4e-15 56.7 0.2 5.1 5 0 0 5 5 5 4 C2 domain SMP_LBD PF17047.5 KOG97070.1 - 0.0013 18.2 0.8 0.0063 16.0 0.8 2.0 1 1 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain Snapin_Pallidin PF14712.6 KOG97071.1 - 1.5e-07 31.8 0.1 1.7e-07 31.6 0.1 1.1 1 0 0 1 1 1 1 Snapin/Pallidin BLOC1_2 PF10046.9 KOG97071.1 - 0.042 14.1 0.1 0.059 13.7 0.1 1.3 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YvrJ PF12841.7 KOG97071.1 - 0.062 12.8 0.3 15 5.2 0.0 3.0 2 1 1 3 3 3 0 YvrJ protein family MKT1_C PF12246.8 KOG97072.1 - 8.7e-61 205.2 5.0 4.2e-60 203.0 4.6 2.1 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 KOG97072.1 - 7.2e-28 96.8 0.1 4.7e-27 94.2 0.1 2.6 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 KOG97072.1 - 1.1e-27 96.5 0.0 3.6e-27 94.8 0.0 2.0 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 KOG97072.1 - 0.00084 19.6 0.0 0.0022 18.3 0.0 1.7 1 0 0 1 1 1 1 XPG I-region EF-hand_4 PF12763.7 KOG97073.1 - 6.4e-51 170.7 8.4 3.7e-49 165.0 2.5 2.7 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand End3 PF12761.7 KOG97073.1 - 2e-27 96.7 11.9 2.6e-13 50.6 0.3 2.2 1 1 1 2 2 2 2 Actin cytoskeleton-regulatory complex protein END3 EF-hand_1 PF00036.32 KOG97073.1 - 0.00016 21.0 3.1 0.0087 15.5 1.2 2.7 2 0 0 2 2 2 2 EF hand DUF3552 PF12072.8 KOG97073.1 - 0.059 12.8 3.2 0.093 12.1 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) EF-hand_6 PF13405.6 KOG97073.1 - 0.18 11.8 1.7 5.6 7.2 0.5 2.8 2 0 0 2 2 2 0 EF-hand domain Mito_carr PF00153.27 KOG97074.1 - 2.5e-61 203.6 4.3 7.2e-20 70.7 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 KOG97074.1 - 1.2e-14 54.5 2.0 3.1e-09 37.2 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOG97074.1 - 1.8e-12 46.1 1.0 0.025 14.5 0.0 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KOG97074.1 - 7.8e-11 40.7 3.7 0.036 13.6 0.1 4.2 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KOG97074.1 - 1.1e-07 31.6 3.4 0.0053 16.6 0.2 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KOG97074.1 - 1.4e-06 27.5 0.8 0.0067 15.9 0.1 3.6 3 0 0 3 3 3 1 EF hand SPARC_Ca_bdg PF10591.9 KOG97074.1 - 0.024 14.9 0.8 7.6 6.9 0.1 2.4 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DNA_mis_repair PF01119.19 KOG97075.1 - 7e-24 83.8 2.0 1.8e-23 82.5 0.6 2.3 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.11 KOG97075.1 - 7.2e-22 77.7 0.0 1.6e-21 76.6 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 KOG97075.1 - 1e-10 41.6 0.0 3.6e-10 39.8 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KOG97075.1 - 2.7e-08 34.3 0.0 8e-08 32.8 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GlcNAc-1_reg PF18440.1 KOG97075.1 - 0.046 14.0 0.0 0.15 12.3 0.0 1.8 1 0 0 1 1 1 0 Putative GlcNAc-1 phosphotransferase regulatory domain Ribosomal_S13 PF00416.22 KOG97076.1 - 6.5e-19 68.6 0.0 1e-16 61.5 0.0 2.1 1 1 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 KOG97076.1 - 0.011 14.5 0.0 0.011 14.5 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) IMS_HHH PF11798.8 KOG97076.1 - 0.016 15.5 0.0 0.064 13.6 0.0 2.0 2 0 0 2 2 2 0 IMS family HHH motif EOS1 PF12326.8 KOG97077.1 - 1.7e-62 210.5 0.5 1.7e-62 210.5 0.5 1.6 2 0 0 2 2 2 1 N-glycosylation protein Tropomyosin_1 PF12718.7 KOG97078.1 - 6.2e-55 185.3 59.4 2.2e-38 131.6 38.0 2.0 1 1 1 2 2 2 2 Tropomyosin like Tropomyosin PF00261.20 KOG97078.1 - 2.4e-07 30.4 54.3 0.00049 19.6 18.8 2.1 1 1 1 2 2 2 2 Tropomyosin CENP-F_leu_zip PF10473.9 KOG97078.1 - 6.4e-06 26.2 58.1 9.6e-06 25.7 13.1 3.4 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KLRAQ PF10205.9 KOG97078.1 - 8.9e-05 22.7 42.5 0.27 11.5 10.7 3.1 1 1 2 3 3 3 3 Predicted coiled-coil domain-containing protein IFP_35_N PF07334.13 KOG97078.1 - 0.00051 20.0 15.0 0.0036 17.3 2.6 4.5 2 2 2 4 4 3 2 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF724 PF05266.14 KOG97078.1 - 0.00069 19.5 41.7 0.031 14.1 19.7 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF724) DUF3450 PF11932.8 KOG97078.1 - 0.0019 17.5 45.0 0.16 11.2 14.9 3.1 1 1 2 3 3 3 2 Protein of unknown function (DUF3450) GAS PF13851.6 KOG97078.1 - 0.0037 16.6 54.9 0.099 12.0 28.6 2.3 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 KOG97078.1 - 0.0045 17.2 52.7 0.41 10.8 21.5 2.9 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) Spc7 PF08317.11 KOG97078.1 - 0.01 14.8 52.5 0.042 12.7 18.5 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Uso1_p115_C PF04871.13 KOG97078.1 - 0.013 15.9 58.8 0.18 12.2 21.7 3.0 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Filament PF00038.21 KOG97078.1 - 0.015 14.9 46.3 0.017 14.7 46.3 1.1 1 0 0 1 1 1 0 Intermediate filament protein DUF4201 PF13870.6 KOG97078.1 - 0.016 14.9 46.3 0.26 11.0 29.8 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) HMMR_C PF15908.5 KOG97078.1 - 0.029 14.6 37.0 0.037 14.3 22.2 3.6 1 1 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal TMF_DNA_bd PF12329.8 KOG97078.1 - 0.031 14.3 65.7 0.29 11.2 10.2 4.2 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF4200 PF13863.6 KOG97078.1 - 0.051 14.0 56.7 1.7 9.1 28.7 3.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Laminin_II PF06009.12 KOG97078.1 - 0.058 13.4 34.0 0.85 9.6 11.4 3.1 1 1 2 3 3 3 0 Laminin Domain II bZIP_1 PF00170.21 KOG97078.1 - 0.072 13.2 51.7 0.13 12.4 3.8 5.7 1 1 4 5 5 5 0 bZIP transcription factor Rootletin PF15035.6 KOG97078.1 - 0.074 13.1 51.6 0.48 10.4 12.3 3.2 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion ADIP PF11559.8 KOG97078.1 - 0.11 12.6 48.9 1.1 9.4 11.6 3.7 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 KOG97078.1 - 0.27 11.8 66.7 1.1 9.8 33.5 2.8 1 1 2 3 3 3 0 Apg6 coiled-coil region Fez1 PF06818.15 KOG97078.1 - 0.3 11.5 46.2 0.15 12.5 24.9 2.1 1 1 1 2 2 2 0 Fez1 DivIC PF04977.15 KOG97078.1 - 0.36 10.6 53.5 0.37 10.6 8.3 5.2 1 1 3 4 4 3 0 Septum formation initiator CEP63 PF17045.5 KOG97078.1 - 0.39 10.6 46.0 0.47 10.3 33.1 2.1 1 1 1 2 2 2 0 Centrosomal protein of 63 kDa ZapB PF06005.12 KOG97078.1 - 0.4 11.2 64.2 3.4 8.2 9.7 4.8 2 1 1 3 3 3 0 Cell division protein ZapB BLOC1_2 PF10046.9 KOG97078.1 - 0.4 11.0 41.2 2.3 8.6 7.4 4.2 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cast PF10174.9 KOG97078.1 - 0.4 8.8 44.3 0.48 8.6 44.3 1.1 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone DUF3584 PF12128.8 KOG97078.1 - 0.47 7.9 43.2 0.51 7.8 43.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Ax_dynein_light PF10211.9 KOG97078.1 - 0.85 9.5 53.1 1 9.3 8.9 3.6 1 1 3 4 4 4 0 Axonemal dynein light chain Lectin_N PF03954.14 KOG97078.1 - 0.96 9.2 27.5 3.9 7.2 7.6 3.4 1 1 1 3 3 3 0 Hepatic lectin, N-terminal domain Jnk-SapK_ap_N PF09744.9 KOG97078.1 - 1 9.6 57.5 1.7 8.8 32.2 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 ERM PF00769.19 KOG97078.1 - 1.2 8.9 56.7 19 5.0 28.6 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family WXG100 PF06013.12 KOG97078.1 - 1.2 9.4 19.3 0.44 10.8 0.5 4.5 2 1 1 3 3 3 0 Proteins of 100 residues with WXG DUF1664 PF07889.12 KOG97078.1 - 1.3 9.1 25.9 1.3 9.1 9.9 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Lebercilin PF15619.6 KOG97078.1 - 1.3 8.6 53.2 1.1 8.8 22.7 2.9 1 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease ROS_MUCR PF05443.11 KOG97078.1 - 1.7 8.7 8.7 0.32 11.1 4.0 2.1 1 1 1 2 2 2 0 ROS/MUCR transcriptional regulator protein TPR_MLP1_2 PF07926.12 KOG97078.1 - 2.4 8.2 59.7 11 6.1 18.1 3.3 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein TMPIT PF07851.13 KOG97078.1 - 2.9 7.1 38.4 2 7.6 13.8 2.0 1 1 1 2 2 2 0 TMPIT-like protein Atg14 PF10186.9 KOG97078.1 - 3.4 6.6 44.1 20 4.1 15.9 2.6 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 FPP PF05911.11 KOG97078.1 - 3.6 5.6 49.3 2.6 6.1 18.5 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Swi5 PF07061.11 KOG97078.1 - 3.8 7.7 46.9 1.5 8.9 2.7 5.1 1 1 4 5 5 5 0 Swi5 Cnn_1N PF07989.11 KOG97078.1 - 4.6 7.5 53.2 3.3 7.9 4.4 4.2 1 1 3 4 4 4 0 Centrosomin N-terminal motif 1 DHR10 PF18595.1 KOG97078.1 - 5.9 7.0 56.6 3.6 7.7 16.2 3.3 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain TolA_bind_tri PF16331.5 KOG97078.1 - 6.1 7.0 36.0 1.5 9.0 2.0 4.1 1 1 2 4 4 4 0 TolA binding protein trimerisation HMMR_N PF15905.5 KOG97078.1 - 6.4 6.1 53.4 19 4.6 25.0 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal bZIP_2 PF07716.15 KOG97078.1 - 6.7 6.9 50.9 1.4 9.1 6.0 5.9 3 2 1 5 5 5 0 Basic region leucine zipper DUF4164 PF13747.6 KOG97078.1 - 7 7.0 38.5 0.052 13.8 10.1 3.2 1 1 1 3 3 3 0 Domain of unknown function (DUF4164) FUSC PF04632.12 KOG97078.1 - 7 5.1 9.8 6.9 5.1 9.1 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family Nup54 PF13874.6 KOG97078.1 - 7.1 6.7 32.2 1.6 8.8 11.5 2.5 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Fib_alpha PF08702.10 KOG97078.1 - 8.8 6.5 32.1 2.4 8.3 9.7 3.1 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF4446 PF14584.6 KOG97078.1 - 8.9 6.3 30.3 0.72 9.8 4.7 3.4 1 1 3 4 4 4 0 Protein of unknown function (DUF4446) DnaJ_C PF01556.18 KOG97080.1 - 2e-25 89.6 0.3 3.3e-25 88.9 0.3 1.4 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOG97080.1 - 3.8e-23 81.4 2.3 8e-23 80.4 2.3 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KOG97080.1 - 5.2e-11 42.8 20.4 5.2e-11 42.8 20.4 1.9 2 0 0 2 2 2 1 DnaJ central domain Med3 PF11593.8 KOG97080.1 - 0.0035 16.6 5.9 0.006 15.8 5.9 1.3 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal ARL2_Bind_BART PF11527.8 KOG97080.1 - 0.12 12.5 2.8 0.27 11.4 2.8 1.5 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART AvrM_N PF18247.1 KOG97080.1 - 0.2 11.6 3.1 1 9.4 0.3 2.5 2 0 0 2 2 2 0 Flax-rust effector AvrM N-terminal domain DUF1752 PF08550.10 KOG97081.1 - 3.4e-08 33.2 0.1 8.5e-08 31.9 0.1 1.8 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Brix PF04427.18 KOG97082.1 - 9.7e-30 104.1 0.1 1.3e-29 103.7 0.1 1.1 1 0 0 1 1 1 1 Brix domain Parvo_coat_N PF08398.10 KOG97082.1 - 0.09 12.9 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Parvovirus coat protein VP1 3-PAP PF12578.8 KOG97083.1 - 0.5 10.1 4.7 0.36 10.6 0.6 2.7 2 0 0 2 2 2 0 Myotubularin-associated protein tRNA-synt_2 PF00152.20 KOG97084.1 - 5e-59 199.9 0.6 7.3e-59 199.4 0.6 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 KOG97084.1 - 6.5e-08 32.4 0.6 2.5e-05 23.9 0.4 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.25 KOG97084.1 - 7e-08 32.3 0.0 1.4e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RNase_HII PF01351.18 KOG97085.1 - 1.4e-71 240.4 0.0 2.1e-71 239.9 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease HII 2-oxoacid_dh PF00198.23 KOG97086.1 - 2.7e-74 249.5 0.9 3.7e-74 249.1 0.9 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KOG97086.1 - 5.6e-17 61.3 0.1 1e-16 60.5 0.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 KOG97086.1 - 4.9e-16 58.8 0.2 1.2e-15 57.5 0.2 1.7 1 0 0 1 1 1 1 e3 binding domain Tom7 PF08038.12 KOG97087.1 - 3.3e-17 61.8 0.1 4.4e-17 61.5 0.1 1.2 1 0 0 1 1 1 1 TOM7 family Ribosomal_L13 PF00572.18 KOG97088.1 - 2.2e-08 34.4 0.1 6.5e-08 32.9 0.1 1.8 1 1 0 1 1 1 1 Ribosomal protein L13 MSP7_C PF12948.7 KOG97088.1 - 0.041 14.5 0.0 0.15 12.8 0.0 1.7 2 0 0 2 2 2 0 MSP7-like protein C-terminal domain Forkhead PF00250.18 KOG97089.1 - 4.1e-33 113.5 0.3 1.3e-32 111.9 0.3 1.9 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 KOG97089.1 - 1.9e-12 47.4 0.1 6.3e-12 45.7 0.1 2.0 1 0 0 1 1 1 1 FHA domain Linker_histone PF00538.19 KOG97089.1 - 0.034 14.5 0.1 0.034 14.5 0.1 2.5 2 0 0 2 2 2 0 linker histone H1 and H5 family Ribosomal_L6 PF00347.23 KOG97090.1 - 7.9e-29 100.2 9.7 9.7e-15 55.0 3.7 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 DUF2096 PF09869.9 KOG97090.1 - 0.0042 17.2 0.2 0.0062 16.6 0.2 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2096) SLS PF14611.6 KOG97090.1 - 0.01 15.6 0.2 0.019 14.8 0.1 1.4 1 1 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator CPT_N PF16484.5 KOG97090.1 - 0.19 11.8 0.0 7.5 6.6 0.0 2.8 2 0 0 2 2 2 0 Carnitine O-palmitoyltransferase N-terminus LRR_6 PF13516.6 KOG97090.1 - 0.92 9.7 2.8 1.5 9.1 0.7 2.5 3 0 0 3 3 3 0 Leucine Rich repeat SUN PF03856.13 KOG97091.1 - 2.7e-99 331.6 11.4 2.7e-99 331.6 11.4 1.5 2 0 0 2 2 2 1 Beta-glucosidase (SUN family) Apt1 PF10351.9 KOG97091.1 - 0.37 9.6 5.2 0.45 9.3 5.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 KOG97091.1 - 1.1 7.8 7.3 1.3 7.5 7.3 1.1 1 0 0 1 1 1 0 Macoilin family MFS_1 PF07690.16 KOG97092.1 - 4.9e-37 127.7 20.6 4.9e-37 127.7 20.6 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 KOG97092.1 - 0.0076 14.7 3.0 0.012 14.0 3.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PMT_4TMC PF16192.5 KOG97092.1 - 0.21 11.2 3.9 0.14 11.7 1.1 2.3 2 1 0 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase DnaJ_C PF01556.18 KOG97093.1 - 4.8e-40 137.0 0.3 6.6e-40 136.6 0.3 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOG97093.1 - 1.1e-25 89.5 0.7 1.8e-25 88.8 0.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KOG97093.1 - 8.3e-16 58.1 19.4 1.5e-15 57.3 19.4 1.4 1 0 0 1 1 1 1 DnaJ central domain Cytochrom_c3_2 PF14537.6 KOG97093.1 - 0.22 12.0 3.9 1.2 9.6 0.7 2.6 2 0 0 2 2 2 0 Cytochrome c3 HypA PF01155.19 KOG97093.1 - 1.8 8.6 11.1 5.6 7.0 2.1 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Anti-TRAP PF15777.5 KOG97093.1 - 3.6 7.6 17.8 0.33 11.0 3.1 2.9 2 1 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein Cytochrome_C7 PF14522.6 KOG97093.1 - 4.8 7.2 8.6 44 4.2 9.1 2.2 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c MTS PF05175.14 KOG97094.1 - 2.8e-09 36.7 0.0 4.2e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 KOG97094.1 - 1.2e-05 25.1 0.0 1.8e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOG97094.1 - 0.00014 22.5 0.0 0.00024 21.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOG97094.1 - 0.022 14.2 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 KOG97094.1 - 0.096 13.4 0.0 0.2 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain TRM PF02005.16 KOG97094.1 - 0.14 11.3 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_11 PF08241.12 KOG97094.1 - 0.15 12.7 0.0 0.28 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Eco57I PF07669.11 KOG97094.1 - 0.19 12.3 0.0 0.34 11.4 0.0 1.4 1 0 0 1 1 1 0 Eco57I restriction-modification methylase Gcd10p PF04189.13 KOG97095.1 - 1.5e-102 342.8 4.8 1.8e-102 342.5 4.8 1.1 1 0 0 1 1 1 1 Gcd10p family Mrr_N PF14338.6 KOG97095.1 - 0.0089 16.1 0.6 0.086 13.0 0.0 2.3 2 0 0 2 2 2 1 Mrr N-terminal domain PH_12 PF16457.5 KOG97095.1 - 1.8 9.1 7.6 0.47 11.0 4.0 1.9 1 1 1 2 2 2 0 Pleckstrin homology domain Methyltr_RsmB-F PF01189.17 KOG97096.1 - 1.7e-82 275.9 0.0 4.1e-82 274.7 0.0 1.7 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 KOG97096.1 - 7.1e-08 32.8 0.0 3e-07 30.8 0.0 2.1 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 KOG97096.1 - 0.028 14.5 0.0 0.066 13.3 0.0 1.6 1 0 0 1 1 1 0 FtsJ-like methyltransferase Actin PF00022.19 KOG97097.1 - 7.6e-54 182.9 0.0 2.1e-32 112.3 0.0 2.6 2 1 0 2 2 2 2 Actin PTPRCAP PF15713.5 KOG97098.1 - 0.041 14.2 1.4 0.078 13.3 1.4 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF3007 PF11460.8 KOG97098.1 - 0.17 12.2 0.0 0.3 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3007) Y_phosphatase2 PF03162.13 KOG97099.1 - 6.2e-58 195.0 0.0 7.6e-58 194.7 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 KOG97099.1 - 1e-05 25.6 0.0 1.2e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 KOG97099.1 - 0.047 13.3 0.0 0.057 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DSPc PF00782.20 KOG97099.1 - 0.061 13.1 0.0 0.087 12.6 0.0 1.2 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Porin_3 PF01459.22 KOG97100.1 - 8.6e-69 232.0 0.9 9.6e-69 231.8 0.9 1.0 1 0 0 1 1 1 1 Eukaryotic porin Vac7 PF12751.7 KOG97101.1 - 1.1e-25 91.0 24.5 1.7e-20 73.8 2.9 5.7 1 1 3 5 5 5 2 Vacuolar segregation subunit 7 DUF3493 PF11998.8 KOG97101.1 - 0.0097 16.1 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 1 Low psii accumulation1 / Rep27 PepSY_TM PF03929.16 KOG97101.1 - 0.74 9.4 2.4 1.9 8.1 2.4 1.7 1 0 0 1 1 1 0 PepSY-associated TM region DSPc PF00782.20 KOG97102.1 - 5.6e-38 129.8 0.0 9.1e-38 129.1 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOG97102.1 - 0.00022 20.9 0.0 0.00034 20.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KOG97102.1 - 0.058 13.5 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate COX4 PF02936.14 KOG97103.1 - 1.1e-32 113.0 0.5 1.2e-32 112.8 0.5 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF1289 PF06945.13 KOG97103.1 - 0.022 14.5 0.6 2.5 8.0 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1289) Phage_Cox PF10743.9 KOG97103.1 - 0.027 14.5 0.1 0.079 13.1 0.1 1.7 1 1 1 2 2 2 0 Regulatory phage protein cox DctP PF03480.13 KOG97103.1 - 0.06 12.7 0.2 0.26 10.6 0.1 1.8 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein, family 7 N1221 PF07923.13 KOG97103.1 - 0.061 12.5 0.0 0.064 12.4 0.0 1.1 1 0 0 1 1 1 0 N1221-like protein COG5 PF10392.9 KOG97104.1 - 2.4e-41 141.0 4.3 2.4e-41 141.0 4.3 2.2 2 1 1 3 3 3 1 Golgi transport complex subunit 5 DUF2647 PF10839.8 KOG97104.1 - 0.14 12.3 0.1 1.4 9.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2647) Syntaxin-6_N PF09177.11 KOG97104.1 - 0.28 11.8 3.5 0.48 11.0 0.5 2.7 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF2011 PF09428.10 KOG97105.1 - 1e-13 51.3 0.2 1e-13 51.3 0.2 1.7 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF2011) Sec23_trunk PF04811.15 KOG97106.1 - 3.1e-65 220.1 0.1 1.6e-64 217.8 0.0 2.2 3 0 0 3 3 3 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 KOG97106.1 - 2.8e-21 75.3 0.4 7.6e-21 73.9 0.4 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 KOG97106.1 - 9e-18 64.8 0.1 2.7e-17 63.3 0.1 1.9 2 0 0 2 2 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 KOG97106.1 - 4.6e-16 58.6 5.7 1e-15 57.5 5.7 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KOG97106.1 - 2.3e-09 37.0 0.0 5e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 KOG97106.1 - 0.0013 18.1 0.0 0.0034 16.8 0.0 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain CDC45 PF02724.14 KOG97106.1 - 0.025 12.9 2.8 0.037 12.3 2.8 1.2 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 KOG97106.1 - 0.039 13.3 4.0 0.11 11.9 4.0 1.7 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RXT2_N PF08595.11 KOG97106.1 - 0.066 13.2 1.1 0.16 12.0 1.1 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal RRN3 PF05327.11 KOG97106.1 - 0.14 10.7 2.7 0.23 10.0 2.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 MEA1 PF06910.11 KOG97106.1 - 0.17 12.5 1.7 0.43 11.2 1.7 1.7 1 0 0 1 1 1 0 Male enhanced antigen 1 (MEA1) Zn_Tnp_IS1595 PF12760.7 KOG97106.1 - 0.35 10.9 2.2 0.71 9.9 2.2 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Pox_Ag35 PF03286.14 KOG97106.1 - 0.38 10.5 2.8 0.82 9.4 2.8 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SDA1 PF05285.12 KOG97106.1 - 0.63 9.4 7.9 1 8.7 7.9 1.2 1 0 0 1 1 1 0 SDA1 Sigma70_ner PF04546.13 KOG97106.1 - 0.71 9.7 7.5 1.6 8.6 7.5 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region GCIP PF13324.6 KOG97106.1 - 1.2 8.6 5.3 0.34 10.5 1.9 1.8 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting NOA36 PF06524.12 KOG97106.1 - 1.3 8.3 16.9 2.3 7.5 16.9 1.3 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 KOG97106.1 - 3.8 7.2 5.0 8.2 6.1 5.0 1.5 1 0 0 1 1 1 0 FAM176 family PPP4R2 PF09184.11 KOG97106.1 - 4.1 6.9 9.8 8.5 5.9 9.8 1.5 1 0 0 1 1 1 0 PPP4R2 MRNIP PF15749.5 KOG97106.1 - 9.2 7.0 6.3 2.1 9.1 0.2 2.4 2 0 0 2 2 2 0 MRN-interacting protein ALG11_N PF15924.5 KOG97107.1 - 7.6e-77 258.1 0.1 1.2e-76 257.5 0.1 1.3 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 KOG97107.1 - 1.9e-21 76.4 0.0 3e-21 75.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOG97107.1 - 2.4e-05 24.8 0.0 3.9e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KOG97107.1 - 0.00027 21.0 0.0 0.00044 20.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_transf_28 PF03033.20 KOG97107.1 - 0.05 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain PH PF00169.29 KOG97108.1 - 9.6e-13 48.6 1.2 1.5e-12 48.0 0.2 1.9 2 0 0 2 2 2 1 PH domain TMPIT PF07851.13 KOG97108.1 - 3.9 6.6 5.5 1.1 8.5 1.7 2.0 2 0 0 2 2 2 0 TMPIT-like protein RNase_HII PF01351.18 KOG97108.1 - 6.9 6.4 5.7 1.2e+02 2.4 5.7 2.5 1 1 0 1 1 1 0 Ribonuclease HII Peptidase_M1 PF01433.20 KOG97110.1 - 7.6e-51 172.8 0.8 1.3e-50 172.0 0.8 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 KOG97110.1 - 2.3e-36 125.7 0.2 4.8e-36 124.7 0.2 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Leuk-A4-hydro_C PF09127.11 KOG97110.1 - 1.8e-34 118.2 0.1 6e-34 116.5 0.1 2.0 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal ATG11 PF10377.9 KOG97110.1 - 0.037 14.1 0.3 0.037 14.1 0.3 1.7 2 0 0 2 2 2 0 Autophagy-related protein 11 PRA1 PF03208.19 KOG97111.1 - 5e-38 130.0 0.2 6.2e-38 129.6 0.2 1.1 1 0 0 1 1 1 1 PRA1 family protein DUF2207 PF09972.9 KOG97111.1 - 0.12 11.1 2.6 0.16 10.7 2.6 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2722 PF10846.8 KOG97112.1 - 5.9e-55 187.1 28.4 9.2e-55 186.4 28.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Bt_P21 PF05560.11 KOG97112.1 - 0.0045 16.6 1.1 0.0073 15.9 1.1 1.2 1 0 0 1 1 1 1 Bacillus thuringiensis P21 molecular chaperone protein COG6 PF06419.11 KOG97113.1 - 1.4e-157 525.7 30.6 1.4e-157 525.7 30.6 1.6 1 1 0 1 1 1 1 Conserved oligomeric complex COG6 zf-AD PF07776.15 KOG97113.1 - 0.0097 16.1 0.6 0.12 12.7 0.0 3.0 3 0 0 3 3 3 1 Zinc-finger associated domain (zf-AD) Fic_N PF13784.6 KOG97113.1 - 0.057 13.5 0.8 0.84 9.7 0.0 2.7 2 0 0 2 2 2 0 Fic/DOC family N-terminal DUF2935 PF11155.8 KOG97113.1 - 0.51 10.7 5.8 0.39 11.0 0.2 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) Pro_CA PF00484.19 KOG97114.1 - 1.1e-39 136.2 0.4 1.4e-39 135.9 0.4 1.1 1 0 0 1 1 1 1 Carbonic anhydrase Iso_dh PF00180.20 KOG97115.1 - 6.6e-75 252.4 0.2 7.5e-75 252.2 0.2 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PIG-H PF10181.9 KOG97116.1 - 8e-20 70.5 0.6 1.8e-19 69.4 0.6 1.6 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component Myb_DNA-bind_7 PF15963.5 KOG97117.1 - 2.5e-25 88.2 0.1 2.5e-25 88.2 0.1 3.6 3 0 0 3 3 3 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 KOG97117.1 - 8.5e-07 29.1 0.0 2.7e-06 27.5 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain tRNA_SAD PF07973.14 KOG97118.1 - 2.8e-08 33.7 0.3 1e-07 31.9 0.1 2.2 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 KOG97118.1 - 0.0003 19.4 0.1 0.00045 18.9 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) DUF3944 PF13099.6 KOG97118.1 - 0.087 12.7 0.0 0.28 11.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) Sortilin-Vps10 PF15902.5 KOG97119.1 - 2.5e-39 135.3 4.0 3e-39 135.1 4.0 1.0 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KOG97119.1 - 1.2e-09 36.7 4.7 0.35 11.0 0.1 6.3 6 0 0 6 6 6 4 BNR/Asp-box repeat BNR_2 PF13088.6 KOG97119.1 - 7.7e-07 28.7 1.7 0.013 14.8 0.1 3.0 2 2 1 3 3 3 2 BNR repeat-like domain Mo-co_dimer PF03404.16 KOG97119.1 - 0.069 13.2 0.7 11 6.1 0.0 3.0 3 0 0 3 3 3 0 Mo-co oxidoreductase dimerisation domain Exo_endo_phos PF03372.23 KOG97120.1 - 1.5e-15 57.3 0.0 2.6e-15 56.6 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 KOG97120.1 - 1.2e-09 38.1 0.4 2.7e-09 37.0 0.4 1.6 1 0 0 1 1 1 1 GRF zinc finger Exo_endo_phos_2 PF14529.6 KOG97120.1 - 1.7e-06 27.9 0.0 0.086 12.7 0.0 2.5 2 0 0 2 2 2 2 Endonuclease-reverse transcriptase Epimerase PF01370.21 KOG97120.1 - 0.16 11.4 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family EamA PF00892.20 KOG97121.1 - 0.2 11.8 0.0 0.27 11.4 0.0 1.1 1 0 0 1 1 1 0 EamA-like transporter family WD40 PF00400.32 KOG97122.1 - 5.6e-08 33.3 7.7 0.0048 17.7 0.5 4.5 4 2 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97122.1 - 0.0011 19.2 0.0 3.2 8.1 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4946 PF16304.5 KOG97123.1 - 0.072 12.8 0.0 0.086 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4946) Y_phosphatase2 PF03162.13 KOG97126.1 - 1.7e-65 219.6 0.0 2.5e-65 219.1 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 KOG97126.1 - 5.7e-07 29.7 0.0 1.1e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 KOG97126.1 - 0.0011 18.8 0.0 0.003 17.4 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOG97126.1 - 0.007 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase TMEM192 PF14802.6 KOG97126.1 - 0.051 12.7 0.1 5.4 6.0 0.0 2.2 2 0 0 2 2 2 0 TMEM192 family Histone PF00125.24 KOG97127.1 - 3.1e-49 166.7 3.4 3.4e-49 166.5 3.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 KOG97127.1 - 2e-06 28.1 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 KOG97127.1 - 5.5e-05 23.8 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 KOG97127.1 - 0.00011 22.3 0.8 0.00015 21.9 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 KOG97127.1 - 0.0018 18.5 0.9 0.0023 18.2 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KOG97127.1 - 0.035 14.2 0.2 0.058 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 KOG97128.1 - 2.7e-09 37.1 0.1 3.2e-09 36.9 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 KOG97128.1 - 5.5e-05 23.2 0.1 7.8e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 KOG97128.1 - 0.00014 22.3 0.1 0.00016 22.1 0.1 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOG97128.1 - 0.00021 21.5 0.1 0.00036 20.7 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 KOG97128.1 - 0.00029 21.2 0.1 0.00039 20.7 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 KOG97128.1 - 0.0089 16.1 0.0 0.011 15.8 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KOG97128.1 - 0.04 13.9 0.0 0.057 13.4 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.13 KOG97128.1 - 0.073 13.6 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Glyco_transf_15 PF01793.16 KOG97129.1 - 7.5e-88 294.9 20.6 1.3e-56 192.2 10.1 2.1 1 1 1 2 2 2 2 Glycolipid 2-alpha-mannosyltransferase zf-C2H2 PF00096.26 KOG97130.1 - 1.6e-13 50.3 11.0 4.4e-07 30.0 1.1 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOG97130.1 - 1.4e-10 41.1 13.3 1.7e-06 28.2 0.3 3.9 3 1 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOG97130.1 - 1e-09 38.4 9.3 0.00027 21.5 0.8 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOG97130.1 - 5.5e-07 29.4 7.3 0.0015 18.5 0.4 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOG97130.1 - 1.2e-05 25.4 6.1 0.081 13.2 0.3 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOG97130.1 - 2e-05 24.8 3.6 0.0012 19.1 0.2 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type Zn_ribbon_recom PF13408.6 KOG97130.1 - 3.2e-05 24.3 5.0 6.7e-05 23.3 1.8 2.4 2 0 0 2 2 2 1 Recombinase zinc beta ribbon domain zf_UBZ PF18439.1 KOG97130.1 - 0.001 18.6 0.4 0.2 11.3 0.2 2.7 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 KOG97130.1 - 0.031 14.6 0.9 0.073 13.4 0.9 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.15 KOG97130.1 - 0.07 13.2 2.3 1.8 8.7 0.1 2.8 1 1 1 2 2 2 0 BED zinc finger C1_2 PF03107.16 KOG97130.1 - 0.17 12.2 2.1 10 6.5 2.3 2.5 1 1 1 2 2 2 0 C1 domain zf-C2HE PF16278.5 KOG97130.1 - 0.21 12.0 3.1 0.71 10.4 0.7 2.8 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger FYVE PF01363.21 KOG97130.1 - 2.1 8.5 4.6 4.6 7.4 4.6 1.5 1 0 0 1 1 1 0 FYVE zinc finger zf-AN1 PF01428.16 KOG97130.1 - 2.6 8.3 4.7 13 6.0 0.8 2.4 2 0 0 2 2 2 0 AN1-like Zinc finger Bac_surface_Ag PF01103.23 KOG97131.1 - 1.4e-50 172.7 0.7 1.8e-50 172.3 0.7 1.1 1 0 0 1 1 1 1 Surface antigen Cyclin_N PF00134.23 KOG97132.1 - 1.2e-16 60.6 0.5 6.2e-16 58.3 0.3 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 KOG97132.1 - 0.0002 21.7 0.1 0.00052 20.4 0.1 1.8 1 1 0 1 1 1 1 Cyclin C-terminal domain DUF1242 PF06842.12 KOG97133.1 - 1.2e-16 60.2 0.3 1.7e-16 59.7 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Methyltransf_16 PF10294.9 KOG97134.1 - 1e-49 168.6 0.0 1.4e-49 168.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 KOG97134.1 - 0.028 14.0 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 KOG97134.1 - 0.18 11.7 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 KOG97134.1 - 0.21 11.3 0.0 0.33 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) R3H PF01424.22 KOG97135.1 - 5.1e-18 64.8 0.1 1.3e-17 63.5 0.1 1.8 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 KOG97135.1 - 9.1e-10 38.4 57.4 3.4e-05 23.8 16.7 13.3 13 1 0 13 13 13 4 NF-X1 type zinc finger Methyltr_RsmB-F PF01189.17 KOG97136.1 - 8.4e-18 64.7 0.0 3.2e-16 59.6 0.0 2.4 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_15 PF09445.10 KOG97136.1 - 0.088 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_3 PF01596.17 KOG97136.1 - 0.11 11.7 0.0 0.29 10.3 0.0 1.6 1 0 0 1 1 1 0 O-methyltransferase Arb2 PF09757.9 KOG97137.1 - 8.1e-93 310.3 0.1 1.2e-92 309.8 0.1 1.2 1 0 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 KOG97137.1 - 1.1e-87 294.4 0.0 1.7e-87 293.8 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Pkinase PF00069.25 KOG97138.1 - 5.4e-39 134.1 0.0 8.4e-39 133.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97138.1 - 7.1e-28 97.6 0.0 1e-27 97.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG97138.1 - 0.011 15.0 0.0 0.029 13.7 0.0 1.6 1 1 0 1 1 1 0 Kinase-like APH PF01636.23 KOG97138.1 - 0.028 14.3 0.1 2.7 7.8 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family RRM_1 PF00076.22 KOG97141.1 - 1.1e-59 198.1 0.4 2.7e-20 71.9 0.3 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOG97141.1 - 6.6e-09 35.5 0.0 0.00064 19.5 0.0 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 KOG97141.1 - 1.7e-07 30.8 0.8 0.00043 19.9 0.1 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KOG97141.1 - 1.4e-05 24.9 0.6 0.0085 16.1 0.1 3.2 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 KOG97141.1 - 0.0012 19.0 0.3 3.9 7.6 0.0 4.3 3 1 0 4 4 4 1 RNA recognition motif PHM7_cyt PF14703.6 KOG97141.1 - 0.0034 17.6 0.3 3.8 7.7 0.1 3.1 3 0 0 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter Limkain-b1 PF11608.8 KOG97141.1 - 0.0039 17.2 0.1 0.01 15.9 0.1 1.7 1 0 0 1 1 1 1 Limkain b1 DUF3421 PF11901.8 KOG97141.1 - 0.078 13.0 0.1 1.5 8.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3421) SpoV PF08183.11 KOG97142.1 - 0.048 13.6 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 Stage V sporulation protein family ABC_tran PF00005.27 KOG97143.1 - 2.8e-45 154.2 0.2 9.2e-23 81.3 0.0 4.4 3 2 0 3 3 2 2 ABC transporter 4HB PF17947.1 KOG97143.1 - 9.1e-30 102.5 0.2 3.4e-29 100.7 0.2 2.1 1 0 0 1 1 1 1 Four helical bundle domain AAA_21 PF13304.6 KOG97143.1 - 6.4e-15 55.7 1.0 0.034 13.9 0.0 4.7 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOG97143.1 - 2.8e-14 53.1 0.0 7.5e-06 25.5 0.0 4.0 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 KOG97143.1 - 6.3e-09 36.2 0.0 0.0054 17.0 0.0 4.5 5 1 0 5 5 4 2 AAA domain AAA_23 PF13476.6 KOG97143.1 - 1.6e-08 35.3 2.4 0.0013 19.3 0.1 3.4 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 KOG97143.1 - 3.4e-08 33.1 0.2 0.0039 16.9 0.0 2.8 3 0 0 3 3 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOG97143.1 - 1.8e-07 31.2 0.0 0.00086 19.2 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 KOG97143.1 - 5.7e-07 29.8 0.0 6.8e-06 26.2 0.0 2.8 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 KOG97143.1 - 9.7e-07 28.9 0.1 0.002 18.2 0.0 3.2 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_28 PF13521.6 KOG97143.1 - 1.7e-06 28.4 0.0 0.012 15.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 KOG97143.1 - 1.7e-05 25.2 0.0 0.13 12.6 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA PF00004.29 KOG97143.1 - 2e-05 25.0 0.1 0.98 9.8 0.0 4.2 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KOG97143.1 - 2.2e-05 24.6 0.0 0.28 11.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KOG97143.1 - 3.6e-05 24.3 0.0 0.19 12.3 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 KOG97143.1 - 4.6e-05 23.9 0.1 0.31 11.4 0.0 3.8 4 0 0 4 4 4 1 AAA ATPase domain MeaB PF03308.16 KOG97143.1 - 0.00029 19.9 0.2 0.4 9.6 0.1 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MMS19_C PF12460.8 KOG97143.1 - 0.00057 19.1 1.0 2 7.4 0.2 3.4 2 1 1 3 3 3 1 RNAPII transcription regulator C-terminal DUF87 PF01935.17 KOG97143.1 - 0.00088 19.4 1.0 0.38 10.8 0.0 4.0 4 0 0 4 4 3 1 Helicase HerA, central domain AAA_24 PF13479.6 KOG97143.1 - 0.0017 18.1 0.1 1.7 8.3 0.0 3.1 3 0 0 3 3 2 1 AAA domain AAA_14 PF13173.6 KOG97143.1 - 0.002 18.2 0.0 8.8 6.4 0.0 3.8 4 0 0 4 4 3 0 AAA domain AAA_27 PF13514.6 KOG97143.1 - 0.0023 17.6 0.0 2 8.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOG97143.1 - 0.0035 17.1 0.2 6.1 6.5 0.0 3.3 4 0 0 4 4 3 0 AAA domain PduV-EutP PF10662.9 KOG97143.1 - 0.0036 17.0 0.1 0.29 10.9 0.0 3.3 4 0 0 4 4 3 1 Ethanolamine utilisation - propanediol utilisation SbcCD_C PF13558.6 KOG97143.1 - 0.0041 17.3 0.0 0.99 9.7 0.0 3.1 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Rad17 PF03215.15 KOG97143.1 - 0.0043 17.0 0.0 2.2 8.2 0.0 3.0 3 0 0 3 3 2 1 Rad17 P-loop domain NACHT PF05729.12 KOG97143.1 - 0.0045 16.9 0.0 1.6 8.6 0.0 2.7 3 0 0 3 3 2 1 NACHT domain ParcG PF10274.9 KOG97143.1 - 0.0054 16.9 0.4 1.4 9.0 0.0 2.9 2 1 0 2 2 2 1 Parkin co-regulated protein ATPase_2 PF01637.18 KOG97143.1 - 0.007 16.3 0.1 7.5 6.4 0.0 3.5 4 0 0 4 4 3 0 ATPase domain predominantly from Archaea AAA_15 PF13175.6 KOG97143.1 - 0.0086 15.8 4.3 0.33 10.6 0.0 3.7 4 0 0 4 4 3 1 AAA ATPase domain cobW PF02492.19 KOG97143.1 - 0.012 15.3 0.0 7 6.2 0.0 3.1 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain Ploopntkinase3 PF18751.1 KOG97143.1 - 0.012 15.5 0.0 2.1 8.2 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_7 PF12775.7 KOG97143.1 - 0.016 14.7 0.0 6.7 6.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Adaptin_N PF01602.20 KOG97143.1 - 0.02 13.5 0.8 0.068 11.7 0.8 1.8 1 1 0 1 1 1 0 Adaptin N terminal region Roc PF08477.13 KOG97143.1 - 0.021 15.1 0.0 12 6.1 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase CLP1_P PF16575.5 KOG97143.1 - 0.029 14.2 1.0 3.9 7.2 0.0 3.3 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Septin PF00735.18 KOG97143.1 - 0.03 13.6 0.0 2.7 7.2 0.0 2.6 2 0 0 2 2 2 0 Septin NTPase_1 PF03266.15 KOG97143.1 - 0.03 14.2 0.1 14 5.5 0.0 2.9 2 0 0 2 2 2 0 NTPase Cytidylate_kin PF02224.18 KOG97143.1 - 0.033 13.9 0.0 9.4 5.9 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase ATP_bind_1 PF03029.17 KOG97143.1 - 0.035 13.9 0.3 7.7 6.2 0.1 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein T2SSE PF00437.20 KOG97143.1 - 0.038 13.1 0.0 0.36 9.9 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein MutS_V PF00488.21 KOG97143.1 - 0.05 13.6 0.1 4.5 7.3 0.1 2.5 2 0 0 2 2 2 0 MutS domain V AAA_25 PF13481.6 KOG97143.1 - 0.062 12.9 0.0 11 5.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 KOG97143.1 - 0.077 12.1 0.0 7.4 5.6 0.0 2.5 2 0 0 2 2 2 0 G-protein alpha subunit HEAT_EZ PF13513.6 KOG97143.1 - 0.086 13.4 0.6 5.8 7.5 0.0 3.8 3 1 1 4 4 3 0 HEAT-like repeat Mg_chelatase PF01078.21 KOG97143.1 - 0.092 12.1 0.1 1.7 8.0 0.0 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATP-synt_ab PF00006.25 KOG97143.1 - 0.12 12.1 0.0 28 4.3 0.0 3.1 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_13 PF13166.6 KOG97143.1 - 0.24 10.0 3.7 15 4.1 0.0 3.8 4 0 0 4 4 4 0 AAA domain PIN_12 PF16289.5 KOG97143.1 - 3.9 7.9 5.8 4.4 7.8 0.0 3.4 4 0 0 4 4 3 0 PIN domain UPF0052 PF01933.18 KOG97144.1 - 3.8e-69 233.2 0.0 4.8e-69 232.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 DUF3842 PF12953.7 KOG97144.1 - 0.061 13.7 0.2 0.13 12.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3842) HAD PF12710.7 KOG97145.1 - 4.6e-26 92.4 0.0 5.8e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 KOG97145.1 - 2.2e-06 27.2 0.0 3.8e-06 26.5 0.0 1.4 1 1 0 1 1 1 1 Putative Phosphatase UMPH-1 PF05822.12 KOG97145.1 - 0.00029 20.4 0.0 0.00058 19.5 0.0 1.6 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Hydrolase PF00702.26 KOG97145.1 - 0.0017 18.6 0.1 0.2 12.0 0.0 2.9 3 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOG97145.1 - 0.02 15.0 0.5 0.81 9.8 0.3 2.7 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Iso_dh PF00180.20 KOG97146.1 - 2.9e-71 240.4 0.0 3.4e-71 240.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase zf-C3HC4_3 PF13920.6 KOG97147.1 - 1.9e-07 30.9 6.5 3.2e-07 30.1 6.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOG97147.1 - 0.54 10.2 7.0 1.1 9.2 7.0 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DnaJ_C PF01556.18 KOG97148.1 - 1.8e-36 125.4 0.1 2.4e-36 125.1 0.1 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOG97148.1 - 6.9e-23 80.6 0.3 1.3e-22 79.7 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain Forkhead_N PF08430.12 KOG97148.1 - 1 10.0 12.3 2.2 8.9 12.3 1.5 1 0 0 1 1 1 0 Forkhead N-terminal region WD40 PF00400.32 KOG97149.1 - 1.6e-42 142.6 18.1 1.3e-10 41.7 0.1 8.0 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97149.1 - 9.3e-15 54.7 1.9 0.03 14.6 0.0 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOG97149.1 - 5.6e-11 41.8 10.3 0.0081 14.9 0.1 4.8 1 1 4 5 5 5 5 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KOG97149.1 - 2.8e-07 29.8 1.2 0.48 9.3 0.0 4.8 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 KOG97149.1 - 9.6e-07 27.9 1.6 0.12 11.1 0.0 3.9 1 1 3 4 4 4 2 Nup133 N terminal like Hira PF07569.11 KOG97149.1 - 8.7e-05 22.3 0.5 0.73 9.5 0.0 4.4 3 1 3 6 6 6 1 TUP1-like enhancer of split Nbas_N PF15492.6 KOG97149.1 - 0.00042 19.8 0.5 0.85 8.9 0.2 3.0 2 1 0 2 2 2 2 Neuroblastoma-amplified sequence, N terminal PALB2_WD40 PF16756.5 KOG97149.1 - 0.0027 16.7 2.7 0.0075 15.2 0.0 2.7 3 1 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 KOG97149.1 - 0.0033 15.8 0.0 0.0079 14.6 0.0 1.7 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Cytochrom_D1 PF02239.16 KOG97149.1 - 0.0045 15.6 0.0 0.11 11.0 0.1 2.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain Ribosomal_L27_C PF18471.1 KOG97150.1 - 5.7e-91 304.2 19.2 6.7e-91 304.0 19.2 1.1 1 0 0 1 1 1 1 Ribosomal L27 protein C-terminal domain Ribosomal_L27 PF01016.19 KOG97150.1 - 6.3e-32 109.4 0.1 1.1e-31 108.7 0.1 1.4 1 0 0 1 1 1 1 Ribosomal L27 protein ComR_TPR PF18710.1 KOG97150.1 - 0.035 13.6 1.3 0.051 13.1 1.3 1.2 1 0 0 1 1 1 0 ComR tetratricopeptide Nmad5 PF18757.1 KOG97150.1 - 0.044 14.0 1.6 0.074 13.3 0.1 2.0 2 1 0 2 2 2 0 Nucleotide modification associated domain 5 RRM_1 PF00076.22 KOG97151.1 - 1.2e-55 185.3 0.2 1.3e-19 69.8 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KOG97151.1 - 0.0053 16.8 0.2 1.4 9.0 0.0 2.7 3 0 0 3 3 3 2 RNA binding motif RRM_Rrp7 PF17799.1 KOG97151.1 - 0.0073 16.1 0.0 3.3 7.5 0.0 3.0 3 0 0 3 3 3 1 Rrp7 RRM-like N-terminal domain Mito_carr PF00153.27 KOG97152.1 - 5.1e-52 173.8 5.8 1.2e-20 73.2 0.1 4.0 3 1 1 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 KOG97152.1 - 0.0025 17.0 1.0 0.013 14.6 1.0 2.1 1 1 0 1 1 1 1 Gammaproteobacterial serine protease Folate_carrier PF01770.18 KOG97152.1 - 0.14 10.9 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 Reduced folate carrier Ribosomal_L30 PF00327.20 KOG97153.1 - 2.1e-11 43.6 1.4 2.1e-11 43.6 1.4 1.9 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e eRF1_2 PF03464.15 KOG97154.1 - 1.7e-30 106.1 0.5 3e-30 105.2 0.5 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 KOG97154.1 - 1.2e-24 86.9 0.1 4.6e-24 85.1 0.0 2.1 2 0 0 2 2 2 1 eRF1 domain 3 eRF1_1 PF03463.15 KOG97154.1 - 2.4e-22 79.3 0.3 4e-22 78.6 0.3 1.4 1 0 0 1 1 1 1 eRF1 domain 1 RNA12 PF10443.9 KOG97154.1 - 0.016 14.0 0.1 0.019 13.7 0.1 1.2 1 0 0 1 1 1 0 RNA12 protein Citrate_synt PF00285.21 KOG97155.1 - 3.6e-99 332.3 0.0 4.5e-99 331.9 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Gpr1_Fun34_YaaH PF01184.19 KOG97156.1 - 4.4e-94 313.9 18.3 5.2e-94 313.7 18.3 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family RNA_pol_Rpc34 PF05158.12 KOG97157.1 - 3e-113 378.6 1.4 3.4e-113 378.4 1.4 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit Rrf2 PF02082.20 KOG97157.1 - 0.0077 16.6 1.2 0.031 14.6 0.1 2.2 2 0 0 2 2 2 1 Transcriptional regulator B-block_TFIIIC PF04182.12 KOG97157.1 - 0.027 14.6 2.9 2.3 8.4 0.2 2.5 1 1 1 2 2 2 0 B-block binding subunit of TFIIIC RPA_C PF08784.11 KOG97157.1 - 0.071 13.8 0.5 0.29 11.8 0.1 2.3 2 1 0 2 2 2 0 Replication protein A C terminal HTH_46 PF15977.5 KOG97157.1 - 0.15 12.1 0.8 0.43 10.6 0.1 2.1 2 0 0 2 2 2 0 Winged helix-turn-helix DNA binding Swm2 PF17083.5 KOG97158.1 - 9.6e-54 180.9 0.2 1.1e-53 180.7 0.2 1.0 1 0 0 1 1 1 1 Nucleolar protein Swm2 UPF0262 PF06793.12 KOG97158.1 - 0.018 15.2 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0262) VHS PF00790.19 KOG97159.1 - 1.4e-41 141.7 0.1 2.9e-41 140.6 0.1 1.6 1 0 0 1 1 1 1 VHS domain FYVE PF01363.21 KOG97159.1 - 5.2e-19 68.1 2.1 1.2e-18 67.0 2.1 1.6 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 KOG97159.1 - 2.2e-05 24.1 12.3 0.0064 16.3 2.1 3.2 2 0 0 2 2 2 2 Ubiquitin interaction motif FYVE_2 PF02318.16 KOG97159.1 - 0.001 19.3 1.5 0.001 19.3 1.5 2.1 2 0 0 2 2 2 1 FYVE-type zinc finger GAT PF03127.14 KOG97159.1 - 0.16 12.3 5.8 0.046 14.0 1.7 2.3 2 0 0 2 2 2 0 GAT domain zf-AN1 PF01428.16 KOG97159.1 - 0.74 10.0 13.3 0.068 13.4 8.3 1.9 2 0 0 2 2 2 0 AN1-like Zinc finger Autophagy_N PF03986.13 KOG97160.1 - 1.3e-42 145.0 0.6 1.3e-42 145.0 0.6 1.8 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 KOG97160.1 - 1e-13 51.6 0.0 2e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 KOG97160.1 - 1.1e-13 50.4 2.8 1.9e-13 49.6 2.8 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal LCAT PF02450.15 KOG97161.1 - 9.4e-146 486.0 0.3 1.2e-145 485.6 0.3 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF1749 PF08538.10 KOG97161.1 - 0.035 13.2 0.0 0.057 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 KOG97161.1 - 0.079 13.5 0.0 0.18 12.4 0.0 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family Whi5 PF08528.11 KOG97162.1 - 9.2e-10 37.9 2.9 1.6e-09 37.1 2.9 1.4 1 0 0 1 1 1 1 Whi5 like Med9 PF07544.13 KOG97163.1 - 4.3e-25 87.6 2.0 4.3e-25 87.6 2.0 1.8 2 1 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 Tmemb_cc2 PF10267.9 KOG97163.1 - 0.031 13.4 2.8 0.034 13.3 2.8 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Wx5_PLAF3D7 PF09688.10 KOG97163.1 - 0.1 12.6 2.2 0.13 12.2 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) HA2 PF04408.23 KOG97164.1 - 8.2e-17 61.4 0.0 8.2e-17 61.4 0.0 2.7 2 1 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KOG97164.1 - 1.6e-15 57.4 0.6 2.3e-14 53.7 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 KOG97164.1 - 5.6e-15 55.5 0.1 2e-14 53.7 0.0 2.0 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 KOG97164.1 - 1.7e-08 34.4 0.2 4.2e-08 33.2 0.2 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOG97164.1 - 0.00015 22.1 0.0 0.00055 20.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOG97164.1 - 0.0011 18.7 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOG97164.1 - 0.0019 18.5 0.1 0.0046 17.3 0.1 1.6 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 KOG97164.1 - 0.004 17.1 0.0 0.0093 16.0 0.0 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain T2SSE PF00437.20 KOG97164.1 - 0.0041 16.2 0.0 0.0081 15.3 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein NB-ARC PF00931.22 KOG97164.1 - 0.011 15.0 0.0 0.022 13.9 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_14 PF13173.6 KOG97164.1 - 0.027 14.5 0.5 2 8.5 0.3 3.2 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KOG97164.1 - 0.045 14.3 2.9 0.12 12.9 0.2 3.0 2 1 0 2 2 2 0 ABC transporter ATPase PF06745.13 KOG97164.1 - 0.068 12.5 0.0 0.16 11.3 0.0 1.6 1 0 0 1 1 1 0 KaiC PhoH PF02562.16 KOG97164.1 - 0.069 12.6 0.1 0.22 10.9 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein NACHT PF05729.12 KOG97164.1 - 0.15 12.0 0.1 3.3 7.6 0.0 3.0 3 0 0 3 3 3 0 NACHT domain PRK PF00485.18 KOG97165.1 - 2.3e-68 229.8 0.0 3.6e-68 229.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 KOG97165.1 - 2.7e-34 118.5 0.0 4e-34 117.9 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 KOG97165.1 - 1.6e-05 25.5 0.0 4.7e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KOG97165.1 - 0.001 19.5 0.2 2.3 8.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 KOG97165.1 - 0.0042 16.4 0.0 0.0075 15.6 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin CPT PF07931.12 KOG97165.1 - 0.0055 16.6 0.0 0.033 14.0 0.0 2.0 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein Cytidylate_kin PF02224.18 KOG97165.1 - 0.023 14.4 0.3 7.6 6.2 0.0 2.5 3 0 0 3 3 3 0 Cytidylate kinase AAA_33 PF13671.6 KOG97165.1 - 0.083 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 KOG97165.1 - 0.15 12.2 1.0 0.42 10.7 1.0 2.2 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain SPX PF03105.19 KOG97166.1 - 1.4e-40 140.4 28.4 8.2e-27 95.1 12.4 3.0 2 1 1 3 3 3 2 SPX domain Na_sulph_symp PF00939.19 KOG97166.1 - 6.1e-25 88.2 45.3 8.6e-25 87.7 45.3 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KOG97166.1 - 3.8e-19 69.0 55.8 1.2e-15 57.5 20.2 2.5 2 1 0 3 3 3 2 Citrate transporter DUF4667 PF15700.5 KOG97167.1 - 1.5e-36 126.7 18.9 3.7e-35 122.2 18.9 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4667) Sec-ASP3 PF15432.6 KOG97167.1 - 0.13 12.4 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 Accessory Sec secretory system ASP3 Dus PF01207.17 KOG97168.1 - 3.7e-72 243.1 0.1 5.8e-72 242.4 0.0 1.3 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) ACC_central PF08326.12 KOG97169.1 - 4.6e-261 868.2 0.0 5.8e-261 867.9 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 KOG97169.1 - 1.3e-187 624.4 0.0 1.7e-187 624.0 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 KOG97169.1 - 1.5e-50 171.6 0.0 3.6e-50 170.4 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 KOG97169.1 - 1.5e-29 102.7 0.0 3.1e-29 101.7 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KOG97169.1 - 2.4e-21 75.9 0.0 1.5e-20 73.3 0.0 2.3 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 KOG97169.1 - 1.3e-17 63.4 0.4 4.5e-17 61.6 0.4 2.0 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 KOG97169.1 - 0.0026 17.8 0.0 0.015 15.4 0.0 2.3 2 0 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KOG97169.1 - 0.011 15.3 0.0 0.034 13.7 0.0 1.8 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 KOG97169.1 - 0.038 13.7 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Tim17 PF02466.19 KOG97170.1 - 6.2e-26 90.9 3.5 9.8e-26 90.3 3.5 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family HIG_1_N PF04588.13 KOG97171.1 - 8.5e-05 22.7 1.1 8.5e-05 22.7 1.1 1.7 2 0 0 2 2 2 1 Hypoxia induced protein conserved region MBOAT PF03062.19 KOG97172.1 - 5.6e-113 377.8 36.8 6.9e-113 377.5 36.8 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 KOG97172.1 - 0.0005 20.3 6.0 0.0014 18.9 6.0 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Tir_receptor_C PF07489.11 KOG97172.1 - 0.012 15.5 9.2 0.025 14.6 9.2 1.4 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus DUF3439 PF11921.8 KOG97172.1 - 0.052 13.5 8.8 0.62 10.0 3.5 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Peptidase_M76 PF09768.9 KOG97173.1 - 6e-71 237.7 0.6 7.1e-71 237.5 0.6 1.0 1 0 0 1 1 1 1 Peptidase M76 family Tox-MPTase2 PF15638.6 KOG97173.1 - 0.23 11.2 0.1 0.36 10.6 0.1 1.2 1 0 0 1 1 1 0 Metallopeptidase toxin 2 Ribosomal_L9_N PF01281.19 KOG97174.1 - 0.0011 18.5 0.0 0.0019 17.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain APC_u15 PF16636.5 KOG97174.1 - 0.031 14.7 1.5 0.049 14.1 1.5 1.3 1 0 0 1 1 1 0 Unstructured region on APC between APC_crr regions 5 and 6 PEHE PF15275.6 KOG97174.1 - 0.038 14.6 1.0 0.062 13.9 1.0 1.3 1 0 0 1 1 1 0 PEHE domain SWIB PF02201.18 KOG97175.1 - 0.0012 18.7 0.3 0.0047 16.8 0.0 2.2 3 0 0 3 3 3 1 SWIB/MDM2 domain Y_phosphatase2 PF03162.13 KOG97175.1 - 0.031 13.9 0.1 0.081 12.5 0.1 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF2461 PF09365.10 KOG97175.1 - 0.075 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein (DUF2461) MPP6 PF10175.9 KOG97176.1 - 3.5e-21 76.1 29.6 7e-21 75.1 29.6 1.5 1 1 0 1 1 1 1 M-phase phosphoprotein 6 ANAPC4_WD40 PF12894.7 KOG97177.1 - 0.00056 20.2 0.1 1.8 8.9 0.0 3.0 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOG97177.1 - 0.00062 20.5 2.2 0.31 12.0 0.0 4.9 5 1 0 5 5 5 1 WD domain, G-beta repeat Pro_isomerase PF00160.21 KOG97178.1 - 8.6e-12 45.6 0.0 1.6e-11 44.8 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD cobW PF02492.19 KOG97179.1 - 2.8e-45 154.0 0.0 4e-45 153.6 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 KOG97179.1 - 2.6e-07 30.5 0.0 4.4e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 KOG97179.1 - 0.0025 17.7 0.8 0.38 10.6 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 KOG97179.1 - 0.0046 16.7 0.4 0.046 13.5 0.1 2.6 3 0 0 3 3 3 1 P-loop containing region of AAA domain GTP_EFTU PF00009.27 KOG97179.1 - 0.012 15.2 0.2 0.15 11.6 0.2 2.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain NACHT PF05729.12 KOG97179.1 - 0.021 14.8 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 KOG97179.1 - 0.043 13.7 0.1 0.12 12.3 0.1 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 KOG97179.1 - 0.097 13.2 0.0 0.25 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 KOG97179.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_16 PF13191.6 KOG97179.1 - 0.13 12.7 0.0 0.31 11.4 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 KOG97179.1 - 0.14 12.6 2.3 0.2 12.1 0.3 2.1 2 1 0 2 2 2 0 AAA domain Glyco_transf_22 PF03901.17 KOG97180.1 - 1.4e-33 116.7 22.0 1.9e-33 116.3 22.0 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family ThiC-associated PF13667.6 KOG97180.1 - 0.083 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 ThiC-associated domain S1FA PF04689.13 KOG97180.1 - 0.54 10.4 0.1 0.54 10.4 0.1 2.6 2 1 1 3 3 3 0 DNA binding protein S1FA Pkinase PF00069.25 KOG97181.1 - 5.4e-63 212.8 0.0 1.5e-62 211.4 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97181.1 - 3.1e-34 118.4 0.2 2.1e-24 86.2 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOG97181.1 - 5.4e-05 22.6 0.0 0.0009 18.6 0.0 2.7 3 0 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 KOG97181.1 - 0.067 12.0 0.0 0.067 12.0 0.0 2.4 3 0 0 3 3 3 0 Fungal protein kinase APH PF01636.23 KOG97181.1 - 0.1 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Metallophos PF00149.28 KOG97182.1 - 8.7e-35 121.1 0.7 1.3e-34 120.5 0.7 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ubiquitin PF00240.23 KOG97183.1 - 1.7e-07 30.9 0.4 1.9e-07 30.7 0.4 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KOG97183.1 - 0.00034 20.4 0.4 0.00038 20.2 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KOG97183.1 - 0.0058 17.1 0.3 0.031 14.7 0.3 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain CC2D2AN-C2 PF15625.6 KOG97183.1 - 0.13 12.0 0.0 0.16 11.7 0.0 1.1 1 0 0 1 1 1 0 CC2D2A N-terminal C2 domain Chorismate_bind PF00425.18 KOG97184.1 - 4.5e-66 223.0 0.0 6.2e-66 222.6 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 KOG97184.1 - 8.4e-31 107.2 0.0 1.5e-30 106.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 KOG97184.1 - 1.8e-19 70.3 0.0 8e-19 68.3 0.0 2.1 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 KOG97184.1 - 7.9e-07 29.1 0.4 1.7e-06 28.0 0.0 1.7 2 0 0 2 2 2 1 Peptidase C26 Glucosamine_iso PF01182.20 KOG97185.1 - 2.1e-53 181.5 0.0 6.9e-53 179.8 0.0 1.7 2 0 0 2 2 2 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF3215 PF11503.8 KOG97186.1 - 1.8e-24 85.4 0.0 2.1e-24 85.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3215) P34-Arc PF04045.14 KOG97187.1 - 4.8e-92 308.0 0.6 7.5e-92 307.4 0.6 1.3 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Ribosom_S12_S23 PF00164.25 KOG97188.1 - 2.5e-33 114.1 0.8 3.3e-33 113.7 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_S19 PF00203.21 KOG97189.1 - 1.1e-27 95.8 0.0 1.3e-27 95.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 DEAD PF00270.29 KOG97190.1 - 1.7e-43 148.5 0.3 2.9e-43 147.7 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG97190.1 - 3.2e-21 75.8 0.8 3.2e-21 75.8 0.8 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG97190.1 - 1e-09 38.6 0.1 1e-09 38.6 0.1 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOG97190.1 - 0.0022 18.3 0.3 0.0087 16.3 0.0 2.1 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 KOG97190.1 - 0.016 15.5 0.0 0.037 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOG97190.1 - 0.033 13.4 0.1 0.078 12.2 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Flavi_DEAD PF07652.14 KOG97190.1 - 0.043 13.8 0.2 0.16 11.9 0.1 2.0 2 0 0 2 2 2 0 Flavivirus DEAD domain BUD22 PF09073.10 KOG97190.1 - 2.1 7.6 15.6 4.2 6.6 15.6 1.4 1 0 0 1 1 1 0 BUD22 UvrD-helicase PF00580.21 KOG97190.1 - 2.3 7.6 9.8 1.6 8.2 5.1 2.6 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain TRAP_alpha PF03896.16 KOG97190.1 - 6.9 5.8 8.9 13 4.8 8.9 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Cation_efflux PF01545.21 KOG97191.1 - 0.17 11.6 16.5 0.55 9.9 16.4 1.7 1 1 0 1 1 1 0 Cation efflux family UbiA PF01040.18 KOG97193.1 - 3.2e-47 160.9 14.4 3.4e-47 160.9 13.2 1.6 1 1 0 1 1 1 1 UbiA prenyltransferase family MDD_C PF18376.1 KOG97194.1 - 1.1e-64 217.6 0.0 1.6e-64 217.1 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 KOG97194.1 - 1.8e-09 37.7 1.6 6.7e-09 35.9 1.8 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain Trm112p PF03966.16 KOG97197.1 - 1.3e-20 73.8 0.0 1.5e-20 73.5 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein Pkinase PF00069.25 KOG97198.1 - 4.2e-79 265.6 0.1 6.3e-79 265.0 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97198.1 - 5.8e-33 114.3 0.1 2.4e-31 109.0 0.1 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG97198.1 - 2.8e-09 36.7 0.1 3.5e-05 23.3 0.0 2.4 2 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 KOG97198.1 - 0.0043 15.9 0.0 0.0043 15.9 0.0 1.9 3 0 0 3 3 3 1 Fungal protein kinase Kdo PF06293.14 KOG97198.1 - 0.082 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CDC50 PF03381.15 KOG97199.1 - 1.1e-86 290.8 0.8 1.4e-86 290.5 0.8 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Mso1_Sec1_bdg PF14475.6 KOG97200.1 - 2.2e-17 62.4 0.0 4.2e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Sec1-binding region of Mso1 Sacchrp_dh_C PF16653.5 KOG97201.1 - 2e-92 310.1 0.0 2.5e-92 309.7 0.0 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 KOG97201.1 - 6.9e-24 84.6 0.2 9.8e-24 84.1 0.2 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 KOG97201.1 - 2.5e-08 34.0 0.7 9.2e-08 32.2 0.1 2.0 2 0 0 2 2 2 1 NAD(P)H-binding Shikimate_DH PF01488.20 KOG97201.1 - 7.4e-08 32.5 0.1 1.5e-07 31.6 0.1 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 3Beta_HSD PF01073.19 KOG97201.1 - 0.0091 15.0 0.6 0.014 14.5 0.1 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 KOG97201.1 - 0.12 11.9 0.2 0.19 11.2 0.2 1.3 1 0 0 1 1 1 0 NmrA-like family ZNRF_3_ecto PF18212.1 KOG97201.1 - 0.17 11.9 0.1 0.3 11.1 0.1 1.3 1 0 0 1 1 1 0 ZNRF-3 Ectodomain NTF2 PF02136.20 KOG97202.1 - 3.9e-26 92.0 0.3 6.7e-26 91.2 0.3 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 KOG97202.1 - 0.0015 18.3 0.1 0.0038 17.0 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CAF1 PF04857.20 KOG97203.1 - 1.1e-14 54.4 6.8 1.9e-09 37.1 0.0 2.9 2 1 1 3 3 3 2 CAF1 family ribonuclease Mob1_phocein PF03637.17 KOG97203.1 - 0.0066 16.5 0.4 0.016 15.2 0.2 1.7 2 0 0 2 2 2 1 Mob1/phocein family SUIM_assoc PF16619.5 KOG97203.1 - 3.3 7.8 46.5 1.4 9.1 0.1 4.3 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 RRM_1 PF00076.22 KOG97204.1 - 0.0011 18.7 0.0 0.13 12.1 0.0 2.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF572 PF04502.13 KOG97204.1 - 0.34 10.5 21.5 0.47 10.0 21.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Trypan_PARP PF05887.11 KOG97204.1 - 2.1 8.3 7.2 5 7.1 7.2 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Sir1 PF11603.8 KOG97205.1 - 9.3e-24 84.2 5.6 1.1e-16 61.4 0.1 3.5 4 0 0 4 4 4 2 Regulatory protein Sir1 SRP1_TIP1 PF00660.17 KOG97206.1 - 5.3e-27 93.8 0.0 7e-27 93.4 0.0 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family MFS_1 PF07690.16 KOG97207.1 - 2.2e-34 119.0 15.7 2.2e-34 119.0 15.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily AA_permease_2 PF13520.6 KOG97208.1 - 3.5e-38 131.5 48.2 1.1e-37 129.9 48.2 1.6 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOG97208.1 - 2.7e-08 32.8 47.4 0.00013 20.7 32.9 2.5 2 1 0 2 2 2 2 Amino acid permease ABC_membrane_3 PF13748.6 KOG97208.1 - 0.026 13.8 0.3 0.026 13.8 0.3 2.1 2 0 0 2 2 2 0 ABC transporter transmembrane region AAA_26 PF13500.6 KOG97209.1 - 6.2e-49 166.5 0.0 7.6e-49 166.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain DUF1611 PF07755.11 KOG97209.1 - 0.0031 16.8 0.0 0.038 13.3 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1611_C) P-loop domain Aminotran_3 PF00202.21 KOG97210.1 - 1.1e-99 333.8 0.0 2.1e-99 333.0 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 KOG97210.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Mannosyl_trans3 PF11051.8 KOG97211.1 - 7.9e-69 232.1 0.4 1.1e-68 231.6 0.4 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative FAD_binding_8 PF08022.12 KOG97212.1 - 4.1e-30 104.1 0.0 1.2e-29 102.6 0.0 1.9 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_6 PF08030.12 KOG97212.1 - 8e-28 97.5 0.0 1.3e-27 96.8 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 KOG97212.1 - 1.2e-23 83.5 16.0 1.2e-23 83.5 16.0 2.2 3 0 0 3 3 3 1 Ferric reductase like transmembrane component DUF4131 PF13567.6 KOG97212.1 - 1.3 8.7 4.4 4.7 6.8 4.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) MARVEL PF01284.23 KOG97213.1 - 3.8e-12 46.5 3.8 5.7e-12 45.9 3.8 1.3 1 0 0 1 1 1 1 Membrane-associating domain Zn_clus PF00172.18 KOG97214.1 - 1.1e-05 25.4 17.2 2.8e-05 24.1 17.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 KOG97214.1 - 3.5e-05 23.0 0.5 3.5e-05 23.0 0.5 2.1 2 1 0 2 2 2 1 Fungal specific transcription factor domain LZ3wCH PF18517.1 KOG97214.1 - 0.0085 16.2 0.4 0.018 15.1 0.4 1.6 1 0 0 1 1 1 1 Leucine zipper with capping helix domain RecR PF02132.15 KOG97214.1 - 1.6 8.4 6.9 5.8 6.6 6.9 2.0 1 0 0 1 1 1 0 RecR protein Abhydrolase_1 PF00561.20 KOG97215.1 - 5.7e-39 134.3 0.1 6.4e-39 134.1 0.1 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOG97215.1 - 2.4e-13 51.2 0.0 3.2e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOG97215.1 - 5.1e-07 29.2 0.0 2.6e-05 23.6 0.0 2.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.13 KOG97215.1 - 0.02 14.6 0.0 0.49 10.0 0.0 2.5 2 1 0 2 2 2 0 Serine hydrolase (FSH1) PriCT_1 PF08708.11 KOG97215.1 - 0.029 14.1 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 Primase C terminal 1 (PriCT-1) Chlorophyllase2 PF12740.7 KOG97215.1 - 0.04 12.8 0.0 0.059 12.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Ndr PF03096.14 KOG97215.1 - 0.051 12.3 0.0 0.063 12.0 0.0 1.2 1 0 0 1 1 1 0 Ndr family Pec_lyase_N PF04431.13 KOG97215.1 - 0.11 12.8 0.0 0.28 11.4 0.0 1.7 1 0 0 1 1 1 0 Pectate lyase, N terminus STI1 PF17830.1 KOG97215.1 - 0.15 12.0 0.0 0.49 10.4 0.0 1.8 2 0 0 2 2 2 0 STI1 domain Glyco_hydro81C PF17652.1 KOG97216.1 - 4.6e-147 489.8 11.2 6.4e-147 489.4 11.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 KOG97216.1 - 1.3e-95 320.3 8.6 1.3e-95 320.3 8.6 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 81 N-terminal domain Bul1_N PF04425.12 KOG97217.1 - 4.5e-100 335.5 0.2 7.9e-100 334.7 0.2 1.3 1 0 0 1 1 1 1 Bul1 N terminus Bul1_C PF04426.12 KOG97217.1 - 3.6e-70 236.5 5.0 3.6e-70 236.5 5.0 2.2 2 0 0 2 2 2 1 Bul1 C terminus Arrestin_C PF02752.22 KOG97217.1 - 0.0077 16.7 0.2 3.4 8.1 0.1 2.9 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Glyco_hydro_28 PF00295.17 KOG97218.1 - 3.2e-109 364.9 25.2 3.6e-109 364.8 25.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Alpha-amylase PF00128.24 KOG97219.1 - 1.5e-124 415.9 0.0 2.5e-124 415.2 0.0 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 KOG97219.1 - 1.1e-06 28.7 0.0 2.8e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 KOG97219.1 - 0.0085 15.2 0.7 0.013 14.7 0.0 1.5 2 0 0 2 2 2 1 Glycogen debranching enzyme, glucanotransferase domain IL17R_fnIII_D2 PF16578.5 KOG97219.1 - 0.074 13.6 0.1 7.6 7.1 0.0 2.8 2 1 0 2 2 2 0 Interleukin 17 receptor D Zn_clus PF00172.18 KOG97220.1 - 1.2e-07 31.7 13.9 2.6e-07 30.6 13.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 KOG97220.1 - 2e-06 27.1 5.6 3.6e-06 26.2 5.6 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF3949 PF13133.6 KOG97220.1 - 0.031 14.7 0.1 0.076 13.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3949) Sugar_tr PF00083.24 KOG97221.1 - 2.6e-104 349.6 20.0 3.1e-104 349.4 20.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG97221.1 - 2.4e-10 39.9 26.7 1.6e-06 27.3 10.4 2.1 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 KOG97221.1 - 2.2e-08 33.1 1.0 2.2e-08 33.1 1.0 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein Zn_clus PF00172.18 KOG97222.1 - 1.8e-08 34.3 18.9 5e-08 32.9 18.9 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 KOG97222.1 - 2.2e-05 23.6 0.9 3.8e-05 22.9 0.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain ADH_N_2 PF16884.5 KOG97224.1 - 1e-22 80.1 0.0 1.7e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 KOG97224.1 - 3.3e-16 59.4 0.6 5e-16 58.9 0.6 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOG97224.1 - 0.017 16.2 0.0 0.036 15.1 0.0 1.6 1 1 0 1 1 1 0 Zinc-binding dehydrogenase LAB_N PF07578.11 KOG97224.1 - 0.023 14.8 0.1 0.066 13.3 0.1 1.7 1 0 0 1 1 1 0 Lipid A Biosynthesis N-terminal domain ERO1 PF04137.15 KOG97225.1 - 4.4e-114 381.4 0.7 4.4e-114 381.4 0.7 2.0 2 0 0 2 2 2 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) COX14 PF14880.6 KOG97226.1 - 1.8e-24 85.3 2.5 2.2e-24 85.0 2.5 1.0 1 0 0 1 1 1 1 Cytochrome oxidase c assembly Ish1 PF10281.9 KOG97228.1 - 9.8e-53 176.2 52.8 3e-12 46.6 0.2 7.7 7 0 0 7 7 7 6 Putative stress-responsive nuclear envelope protein SAP PF02037.27 KOG97228.1 - 4.1e-05 23.2 0.0 8.5 6.3 0.0 6.1 7 0 0 7 7 7 1 SAP domain DUF3892 PF13031.6 KOG97228.1 - 0.00089 19.8 10.9 5.3 7.7 0.0 5.7 3 2 0 4 4 4 2 Protein of unknown function (DUF3892) HeH PF12949.7 KOG97228.1 - 0.023 14.4 2.1 9.1 6.1 0.0 4.3 4 0 0 4 4 4 0 HeH/LEM domain YtxH PF12732.7 KOG97228.1 - 0.096 13.2 20.3 16 6.1 0.7 6.0 3 1 0 3 3 3 0 YtxH-like protein DUF4286 PF14114.6 KOG97228.1 - 0.1 13.1 9.9 18 5.9 0.3 4.6 4 1 0 4 4 4 0 Domain of unknown function (DUF4286) FtsH_ext PF06480.15 KOG97228.1 - 0.33 11.3 12.3 2.9 8.3 0.4 4.0 3 1 1 4 4 4 0 FtsH Extracellular SAM_2 PF07647.17 KOG97228.1 - 1.9 8.6 16.4 7.4 6.8 0.1 6.4 7 0 0 7 7 7 0 SAM domain (Sterile alpha motif) PhageMin_Tail PF10145.9 KOG97228.1 - 4.4 7.1 5.8 59 3.4 0.2 3.4 2 1 0 3 3 3 0 Phage-related minor tail protein HMG_CoA_synt_C PF08540.10 KOG97230.1 - 9e-119 396.2 5.7 1.1e-118 395.9 5.7 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 KOG97230.1 - 3.7e-102 339.5 1.0 6.1e-102 338.8 1.0 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal FAD_binding_6 PF00970.24 KOG97231.1 - 2.5e-29 101.5 0.0 6.3e-29 100.3 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KOG97231.1 - 3.9e-25 88.6 0.0 6.5e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KOG97231.1 - 0.0006 20.0 0.0 0.0035 17.5 0.0 2.0 1 1 0 2 2 2 1 Ferric reductase NAD binding domain Tubulin_C PF03953.17 KOG97232.1 - 4.3e-50 169.1 0.1 6.2e-50 168.6 0.1 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 KOG97232.1 - 2.9e-28 99.4 0.0 5.9e-28 98.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Sugar_tr PF00083.24 KOG97233.1 - 8.8e-49 166.6 11.9 2.7e-48 165.0 11.9 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG97233.1 - 1.4e-24 86.7 5.2 7.6e-16 58.0 3.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily FAM178 PF14816.6 KOG97233.1 - 0.04 12.9 0.0 0.072 12.1 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function, FAM178 MFS_3 PF05977.13 KOG97233.1 - 0.047 12.1 0.3 0.089 11.2 0.3 1.4 1 0 0 1 1 1 0 Transmembrane secretion effector Gtr1_RagA PF04670.12 KOG97234.1 - 9.9e-95 316.3 1.7 1.3e-94 315.9 1.7 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 KOG97234.1 - 2e-09 37.3 0.3 8.2e-09 35.3 0.1 1.9 2 0 0 2 2 2 1 Ras family Roc PF08477.13 KOG97234.1 - 1.8e-08 34.6 0.0 4.6e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG97234.1 - 1e-07 31.6 0.1 2.2e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOG97234.1 - 2e-07 31.1 0.0 4.3e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 KOG97234.1 - 0.0069 16.9 0.1 0.02 15.4 0.1 2.0 2 1 0 2 2 2 1 ABC transporter DUF815 PF05673.13 KOG97234.1 - 0.043 13.0 0.0 0.1 11.7 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 KOG97234.1 - 0.048 13.4 0.3 0.1 12.4 0.3 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Guanylate_kin PF00625.21 KOG97234.1 - 0.049 13.3 1.2 0.17 11.6 0.3 2.2 2 1 0 2 2 2 0 Guanylate kinase RsgA_GTPase PF03193.16 KOG97234.1 - 0.056 13.3 0.6 1.3 8.9 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase Pyr_redox_2 PF07992.14 KOG97235.1 - 7.8e-50 169.8 0.0 9.5e-50 169.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOG97235.1 - 1.3e-13 51.3 0.1 3.9e-11 43.3 0.2 3.2 2 2 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOG97235.1 - 9.9e-06 25.0 0.5 1.4 8.1 0.0 3.2 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_28 PF02636.17 KOG97235.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase K_oxygenase PF13434.6 KOG97235.1 - 0.14 11.3 0.0 1.9 7.5 0.1 2.7 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 KOG97235.1 - 0.24 11.4 0.3 3.2 7.7 0.1 2.7 2 2 2 4 4 4 0 FAD-NAD(P)-binding Exo_endo_phos PF03372.23 KOG97237.1 - 1.1e-26 93.8 0.0 1.4e-26 93.4 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Nab6_mRNP_bdg PF10567.9 KOG97238.1 - 6.1e-121 403.8 14.5 6.1e-121 403.8 14.5 3.5 3 1 0 3 3 3 1 RNA-recognition motif RRM PF10378.9 KOG97238.1 - 3.6e-21 74.6 4.1 3.6e-21 74.6 4.1 2.7 2 0 0 2 2 2 1 Putative RRM domain RRM_1 PF00076.22 KOG97238.1 - 2.4e-05 24.1 0.2 0.0047 16.7 0.0 4.0 5 0 0 5 5 5 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CAMSAP_CC1 PF17095.5 KOG97238.1 - 0.17 11.8 1.4 0.39 10.6 1.4 1.5 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin MFS_1 PF07690.16 KOG97239.1 - 1.5e-26 93.2 63.1 1.7e-24 86.4 63.1 2.5 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 KOG97239.1 - 4.7e-08 31.9 19.3 8.6e-08 31.1 19.3 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 KOG97239.1 - 0.00028 19.9 4.1 0.00028 19.9 4.1 3.6 2 1 1 4 4 4 3 Sugar (and other) transporter Ac76 PF05814.11 KOG97239.1 - 0.066 13.2 0.6 0.066 13.2 0.6 3.1 4 0 0 4 4 4 0 Orf76 (Ac76) Anp1 PF03452.14 KOG97240.1 - 6.6e-120 399.4 0.0 9.2e-120 399.0 0.0 1.2 1 0 0 1 1 1 1 Anp1 TAF8_C PF10406.9 KOG97241.1 - 4.8e-18 65.4 0.2 4.8e-18 65.4 0.2 3.2 3 0 0 3 3 3 1 Transcription factor TFIID complex subunit 8 C-term Sorting_nexin PF03700.13 KOG97241.1 - 0.012 16.2 6.3 0.012 16.2 6.3 1.9 2 0 0 2 2 2 0 Sorting nexin, N-terminal domain DUF3886 PF13025.6 KOG97241.1 - 0.32 11.2 11.6 1.1 9.5 11.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) Spt20 PF12090.8 KOG97242.1 - 1.9 8.0 20.3 0.11 12.1 13.6 2.1 2 0 0 2 2 2 0 Spt20 family DUF1631 PF07793.11 KOG97242.1 - 7.3 4.9 13.1 9.6 4.5 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) PAT1 PF09770.9 KOG97242.1 - 7.8 4.6 16.8 8.9 4.4 16.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CTK3_C PF12350.8 KOG97243.1 - 8.1e-18 64.3 1.2 1.5e-17 63.5 1.2 1.5 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus CTK3 PF12243.8 KOG97243.1 - 0.003 17.6 0.7 0.41 10.6 0.1 2.7 2 0 0 2 2 2 2 CTD kinase subunit gamma CTK3 V-set_2 PF15910.5 KOG97243.1 - 0.0038 17.3 1.0 0.0073 16.4 0.3 1.8 2 0 0 2 2 2 1 ICOS V-set domain Bul1_N PF04425.12 KOG97244.1 - 3.5e-172 573.2 3.6 3.5e-172 573.2 3.6 2.7 2 1 1 3 3 3 1 Bul1 N terminus Bul1_C PF04426.12 KOG97244.1 - 2e-114 381.6 15.6 2e-114 381.6 15.6 3.3 4 0 0 4 4 4 1 Bul1 C terminus Ubie_methyltran PF01209.18 KOG97245.1 - 2.2e-104 347.9 0.1 2.6e-104 347.7 0.1 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 KOG97245.1 - 2e-11 44.5 0.0 6.5e-11 42.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOG97245.1 - 1.4e-09 37.9 0.0 2.6e-09 37.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOG97245.1 - 3.1e-09 37.4 0.0 8.5e-09 35.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOG97245.1 - 1.2e-07 32.4 0.0 2e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOG97245.1 - 4e-05 23.5 0.0 6.5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KOG97245.1 - 0.0061 16.4 0.0 0.26 11.1 0.0 2.3 1 1 1 2 2 2 1 Hypothetical methyltransferase ADH_zinc_N PF00107.26 KOG97245.1 - 0.18 11.8 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Zds_C PF08632.10 KOG97246.1 - 3.1e-28 97.3 0.7 7.4e-28 96.1 0.7 1.7 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF1892 PF08987.10 KOG97247.1 - 4.7e-49 165.1 6.6 5.2e-49 165.0 6.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1892) Phage_gp53 PF11246.8 KOG97247.1 - 0.038 13.7 0.0 0.04 13.6 0.0 1.2 1 0 0 1 1 1 0 Base plate wedge protein 53 zf-C3HC PF07967.13 KOG97248.1 - 3.6e-11 43.2 4.9 8.7e-10 38.8 2.1 2.5 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.10 KOG97248.1 - 1.9e-05 24.7 4.6 0.00015 21.8 0.9 2.8 2 1 0 2 2 2 2 Rsm1-like Pribosyltran PF00156.27 KOG97249.1 - 3.8e-16 59.0 0.2 5.9e-16 58.4 0.2 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain SRP19 PF01922.17 KOG97250.1 - 5.6e-29 100.9 0.0 1.1e-28 100.0 0.0 1.5 1 0 0 1 1 1 1 SRP19 protein PXA PF02194.15 KOG97251.1 - 9e-29 100.7 2.3 9e-29 100.7 2.3 2.8 3 1 0 3 3 3 1 PXA domain Nexin_C PF08628.12 KOG97251.1 - 9.7e-26 90.5 0.7 2.9e-25 89.0 0.1 2.2 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 KOG97251.1 - 6e-14 52.0 5.6 6e-14 52.0 5.6 3.1 3 0 0 3 3 3 1 PX domain Nup188 PF10487.9 KOG97252.1 - 1.4e-246 820.9 46.0 1.4e-246 820.9 46.0 1.7 2 0 0 2 2 2 1 Nucleoporin subcomplex protein binding to Pom34 Nup188_C PF18378.1 KOG97252.1 - 1.5e-20 73.4 5.2 1.5e-20 73.4 5.2 2.5 3 0 0 3 3 3 1 Nuclear pore protein NUP188 C-terminal domain WD40 PF00400.32 KOG97253.1 - 7.4e-22 77.3 11.9 0.00033 21.4 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97253.1 - 5.1e-17 62.0 0.1 1.6e-05 25.1 0.0 5.1 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOG97253.1 - 2.9e-05 23.2 0.1 1.7 7.5 0.0 3.2 3 0 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KOG97253.1 - 0.011 15.6 0.0 1.1 9.1 0.0 3.0 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 KOG97253.1 - 0.024 14.6 0.3 10 6.2 0.2 2.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOG97253.1 - 0.16 10.3 0.0 0.26 9.6 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz CUE PF02845.16 KOG97254.1 - 5.8e-07 29.1 0.0 8.4e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 CUE domain Glyco_transf_20 PF00982.21 KOG97255.1 - 9.3e-173 575.2 1.6 1.5e-172 574.6 1.6 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 KOG97255.1 - 7.3e-51 172.5 0.1 2.1e-50 171.1 0.0 1.8 2 0 0 2 2 2 1 Trehalose-phosphatase Glyco_trans_1_4 PF13692.6 KOG97255.1 - 0.013 15.9 0.0 0.036 14.5 0.0 1.8 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 KOG97255.1 - 0.026 14.2 0.1 0.05 13.3 0.1 1.4 1 0 0 1 1 1 0 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 KOG97255.1 - 0.036 13.6 0.0 0.095 12.2 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 IL34 PF15036.6 KOG97255.1 - 0.091 12.8 0.5 0.4 10.7 0.0 2.3 3 0 0 3 3 3 0 Interleukin 34 Fungal_trans_2 PF11951.8 KOG97256.1 - 9e-115 383.5 1.7 1.2e-114 383.2 1.7 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG97256.1 - 1e-12 48.0 8.1 2.4e-12 46.8 8.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAM104 PF15434.6 KOG97256.1 - 0.047 14.2 2.1 0.2 12.2 2.1 2.0 1 0 0 1 1 1 0 Family 104 SR-25 PF10500.9 KOG97256.1 - 0.05 13.2 7.8 0.094 12.3 7.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIID-18kDa PF02269.16 KOG97257.1 - 9.1e-36 121.8 0.0 1.4e-35 121.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit TAF PF02969.17 KOG97257.1 - 0.0078 16.4 0.1 0.087 13.0 0.0 2.2 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 KOG97257.1 - 0.72 10.2 8.7 0.81 10.1 0.0 3.0 3 1 0 3 3 3 0 Core histone H2A/H2B/H3/H4 CDC45 PF02724.14 KOG97257.1 - 5.5 5.2 11.8 5.8 5.1 11.8 1.1 1 0 0 1 1 1 0 CDC45-like protein VPS9 PF02204.18 KOG97258.1 - 4.1e-30 104.1 0.0 9.6e-30 102.9 0.0 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 KOG97258.1 - 5.7e-13 49.0 1.1 1.5e-12 47.6 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF5601) CUE PF02845.16 KOG97258.1 - 2e-11 43.4 0.0 3.4e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 CUE domain Asn_synthase PF00733.21 KOG97259.1 - 4.6e-23 82.4 0.4 5e-14 52.7 0.0 3.1 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 KOG97259.1 - 2.9e-11 43.3 0.0 4.7e-10 39.4 0.0 2.6 2 1 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 KOG97259.1 - 5.5e-08 33.1 0.0 1.6e-07 31.6 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 KOG97259.1 - 0.0036 16.8 0.0 0.023 14.1 0.0 2.1 1 1 0 1 1 1 1 Aluminium induced protein DUF3124 PF11322.8 KOG97259.1 - 0.074 13.3 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3124) Rad10 PF03834.14 KOG97260.1 - 1.1e-36 125.3 1.5 1.5e-36 124.9 1.5 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Calreticulin PF00262.18 KOG97260.1 - 0.03 13.2 1.2 0.039 12.8 1.0 1.4 1 1 0 1 1 1 0 Calreticulin family Prefoldin PF02996.17 KOG97261.1 - 3.4e-29 101.2 2.0 3.4e-29 101.2 2.0 1.4 1 1 0 1 1 1 1 Prefoldin subunit Uds1 PF15456.6 KOG97261.1 - 0.14 12.3 7.4 0.15 12.3 4.1 2.0 2 0 0 2 2 2 0 Up-regulated During Septation PHM7_cyt PF14703.6 KOG97261.1 - 0.42 10.8 8.5 0.54 10.5 8.4 1.4 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Utp14 PF04615.13 KOG97262.1 - 5.2e-206 686.7 77.1 5.2e-206 686.7 77.1 2.0 1 1 1 2 2 2 1 Utp14 protein Proteasome PF00227.26 KOG97263.1 - 3.1e-58 196.4 0.0 4.2e-58 196.0 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOG97263.1 - 1.6e-09 37.3 0.2 5.3e-09 35.6 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RPM2 PF08579.11 KOG97264.1 - 2.6e-55 186.0 4.9 2.6e-55 186.0 4.9 2.8 2 0 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) PPR_2 PF13041.6 KOG97264.1 - 0.0018 18.4 3.2 2.5 8.4 0.0 5.0 5 0 0 5 5 5 2 PPR repeat family Desmo_N PF06771.11 KOG97264.1 - 0.069 13.5 1.4 4.6 7.7 0.1 3.6 3 0 0 3 3 3 0 Viral Desmoplakin N-terminus PPR PF01535.20 KOG97264.1 - 0.24 11.7 0.9 35 5.0 0.0 4.1 4 0 0 4 4 4 0 PPR repeat F-box-like PF12937.7 KOG97265.1 - 3.3e-10 39.7 0.0 6.8e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOG97265.1 - 3.1e-09 36.5 0.0 8.2e-09 35.1 0.0 1.7 1 0 0 1 1 1 1 F-box domain UIM PF02809.20 KOG97265.1 - 6.9e-06 25.6 19.3 0.0027 17.5 0.7 3.9 3 0 0 3 3 3 2 Ubiquitin interaction motif F-box_4 PF15966.5 KOG97265.1 - 0.066 13.1 0.1 0.066 13.1 0.1 2.2 2 1 0 2 2 2 0 F-box U5_2-snRNA_bdg PF10597.9 KOG97265.1 - 0.096 12.8 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 U5-snRNA binding site 2 of PrP8 DUF1635 PF07795.11 KOG97265.1 - 2.3 8.0 5.6 3.3 7.5 3.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) TetR_C_37 PF18665.1 KOG97265.1 - 3.4 8.3 6.7 7.3 7.2 0.1 3.4 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain FAD_binding_6 PF00970.24 KOG97266.1 - 9.9e-31 106.0 0.0 1.5e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KOG97266.1 - 1.5e-25 89.9 0.0 2.2e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KOG97266.1 - 4.3e-05 23.7 0.0 0.0021 18.2 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain AmiS_UreI PF02293.15 KOG97266.1 - 0.055 13.5 0.8 0.088 12.8 0.8 1.2 1 0 0 1 1 1 0 AmiS/UreI family transporter ALO PF04030.14 KOG97267.1 - 2.4e-104 348.8 0.4 3.1e-104 348.4 0.4 1.1 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 KOG97267.1 - 5.9e-25 87.6 0.0 8.9e-25 87.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 KOG97267.1 - 0.0099 16.0 0.3 0.028 14.5 0.3 1.8 1 0 0 1 1 1 1 Berberine and berberine like Tubulin_C PF03953.17 KOG97268.1 - 1.5e-51 173.8 0.0 2.1e-51 173.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Cys_Met_Meta_PP PF01053.20 KOG97270.1 - 2.2e-21 75.9 0.0 5.1e-21 74.6 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme ATP-synt_J PF04911.12 KOG97271.1 - 6.6e-29 99.3 1.0 7.3e-29 99.1 1.0 1.0 1 0 0 1 1 1 1 ATP synthase j chain zf-C2H2 PF00096.26 KOG97272.1 - 5.2e-06 26.6 15.6 0.00036 20.8 3.9 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOG97272.1 - 0.00031 21.0 9.0 0.00062 20.1 4.4 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOG97272.1 - 0.0027 18.4 15.0 0.023 15.5 3.1 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger Dus PF01207.17 KOG97273.1 - 3.6e-88 295.7 0.0 4.4e-88 295.3 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Cupin_5 PF06172.11 KOG97274.1 - 3.5e-44 150.4 0.0 4.2e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) Sybindin PF04099.12 KOG97275.1 - 1.2e-19 70.7 0.3 1.5e-19 70.3 0.3 1.1 1 0 0 1 1 1 1 Sybindin-like family LptD PF04453.14 KOG97275.1 - 0.00058 19.2 0.6 0.0013 18.0 0.3 1.5 1 1 1 2 2 2 1 LPS transport system D Sedlin_N PF04628.13 KOG97275.1 - 0.0068 16.5 0.1 0.0082 16.3 0.1 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Zn_clus PF00172.18 KOG97276.1 - 0.043 13.9 14.2 0.1 12.7 14.2 1.7 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain HMG-CoA_red PF00368.18 KOG97277.1 - 3.3e-144 480.4 1.0 5.7e-144 479.7 1.0 1.4 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 KOG97277.1 - 1.7e-46 157.9 1.9 4.8e-46 156.5 1.9 1.8 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 KOG97277.1 - 4.7e-08 33.0 6.0 4.7e-08 33.0 6.0 2.0 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation FKBP_C PF00254.28 KOG97278.1 - 1.4e-28 99.1 0.1 4.2e-28 97.5 0.0 1.9 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 KOG97278.1 - 1.6e-22 80.0 2.7 1.6e-22 80.0 2.7 3.0 2 2 0 2 2 1 1 Nucleoplasmin-like domain YL1 PF05764.13 KOG97278.1 - 0.0009 19.4 26.9 0.0009 19.4 26.9 2.9 2 1 0 2 2 1 1 YL1 nuclear protein TFIIF_alpha PF05793.12 KOG97278.1 - 0.34 9.4 73.7 0.03 12.9 24.9 2.2 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Presenilin PF01080.17 KOG97278.1 - 0.7 8.6 19.8 0.4 9.4 7.5 2.1 2 0 0 2 2 2 0 Presenilin DUF4045 PF13254.6 KOG97278.1 - 0.8 9.3 21.0 0.44 10.1 9.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) PRP21_like_P PF12230.8 KOG97278.1 - 1.4 8.8 32.0 2.8 7.8 17.8 2.2 2 0 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein CCSAP PF15748.5 KOG97278.1 - 3.2 7.8 27.7 4.2 7.5 14.5 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated RR_TM4-6 PF06459.12 KOG97278.1 - 4.3 7.1 37.9 5.6 6.7 21.3 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Nop53 PF07767.11 KOG97278.1 - 4.4 6.6 48.4 1.7 8.0 26.3 2.1 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Mpp10 PF04006.12 KOG97278.1 - 7.7 4.8 58.4 1.2 7.5 21.3 2.2 2 0 0 2 2 2 0 Mpp10 protein Nop14 PF04147.12 KOG97278.1 - 8.8 4.4 62.0 0.72 8.0 22.5 2.1 2 0 0 2 2 2 0 Nop14-like family PhzC-PhzF PF02567.16 KOG97279.1 - 5.8e-75 252.4 0.0 6.6e-75 252.2 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.11 KOG97279.1 - 0.0045 16.1 0.0 0.059 12.4 0.0 2.0 2 0 0 2 2 2 1 Proline racemase Ribosomal_L6e PF01159.19 KOG97280.1 - 7.1e-38 129.6 3.4 9.9e-38 129.1 3.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e C2 PF00168.30 KOG97281.1 - 6.1e-56 187.1 1.6 4e-18 65.6 0.0 5.6 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.5 KOG97281.1 - 0.038 13.5 0.3 2 7.9 0.0 2.3 2 0 0 2 2 2 0 Synaptotagmin-like mitochondrial-lipid-binding domain Noelin-1 PF12308.8 KOG97281.1 - 0.18 11.8 0.2 1.4 8.9 0.2 2.4 1 1 0 1 1 1 0 Neurogenesis glycoprotein Dor1 PF04124.12 KOG97282.1 - 2e-74 250.3 7.5 3.9e-74 249.3 7.5 1.4 1 0 0 1 1 1 1 Dor1-like family TFIIF_alpha PF05793.12 KOG97282.1 - 0.00058 18.6 32.7 0.00058 18.6 32.7 2.3 2 0 0 2 2 2 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) TPR_7 PF13176.6 KOG97282.1 - 0.063 13.3 0.0 0.23 11.6 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat V_ATPase_I PF01496.19 KOG97282.1 - 0.28 9.1 25.8 0.035 12.0 13.0 2.4 2 1 0 2 2 2 0 V-type ATPase 116kDa subunit family GAGA_bind PF06217.12 KOG97282.1 - 0.36 11.1 18.3 0.54 10.5 12.0 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family DUF966 PF06136.13 KOG97282.1 - 0.51 10.0 26.7 0.0067 16.2 15.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF966) Neur_chan_memb PF02932.16 KOG97282.1 - 1.2 9.2 10.7 0.19 11.8 5.1 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region BUD22 PF09073.10 KOG97282.1 - 1.9 7.7 55.9 0.01 15.2 37.7 2.1 2 0 0 2 2 2 0 BUD22 DUF2201_N PF13203.6 KOG97282.1 - 1.9 8.0 11.6 5.9 6.4 11.6 1.8 1 1 0 1 1 1 0 Putative metallopeptidase domain Nop14 PF04147.12 KOG97282.1 - 2.7 6.1 55.7 0.5 8.5 38.4 2.2 2 0 0 2 2 2 0 Nop14-like family Presenilin PF01080.17 KOG97282.1 - 4.4 6.0 30.1 0.087 11.6 19.9 2.1 2 0 0 2 2 2 0 Presenilin Cellulose_synt PF03552.14 KOG97282.1 - 6.2 5.2 7.6 11 4.4 7.6 1.4 1 0 0 1 1 1 0 Cellulose synthase Dak1 PF02733.17 KOG97283.1 - 1.6e-108 362.3 0.6 2.3e-108 361.8 0.6 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 KOG97283.1 - 2.6e-45 154.4 2.4 3.3e-45 154.1 1.0 1.9 2 0 0 2 2 2 1 DAK2 domain SSrecog PF03531.14 KOG97284.1 - 4.7e-30 103.3 0.9 5.3e-28 96.7 0.1 3.5 3 0 0 3 3 3 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 KOG97284.1 - 7.6e-28 96.8 0.1 1.1e-24 86.6 0.0 3.2 3 0 0 3 3 3 1 Histone chaperone Rttp106-like POB3_N PF17292.2 KOG97284.1 - 1.1e-27 96.3 0.3 7.4e-26 90.4 0.1 2.7 2 0 0 2 2 2 1 POB3-like N-terminal PH domain IBR PF01485.21 KOG97285.1 - 4.2e-13 49.3 27.7 1.1e-08 35.1 2.5 4.1 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 KOG97285.1 - 0.02 15.2 9.2 0.02 15.2 9.2 4.9 3 2 2 5 5 5 0 Ring finger domain COPIIcoated_ERV PF07970.12 KOG97286.1 - 8e-30 104.3 0.0 1.2e-29 103.8 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter Fig1 PF12351.8 KOG97287.1 - 4.4 7.2 8.2 12 5.7 0.0 2.8 4 0 0 4 4 4 0 Ca2+ regulator and membrane fusion protein Fig1 AAA_lid_10 PF17872.1 KOG97288.1 - 4.1e-45 151.9 0.1 2.5e-44 149.4 0.1 2.5 1 0 0 1 1 1 1 AAA lid domain BAH PF01426.18 KOG97288.1 - 4.1e-19 68.6 0.1 1e-18 67.4 0.1 1.8 1 0 0 1 1 1 1 BAH domain AAA PF00004.29 KOG97288.1 - 4.7e-19 69.1 0.0 4e-18 66.1 0.0 2.7 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOG97288.1 - 2.2e-07 31.2 0.1 2.2e-06 28.0 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 KOG97288.1 - 5.3e-07 30.2 0.0 4.6e-05 23.9 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain SDA1 PF05285.12 KOG97288.1 - 0.004 16.6 25.6 0.004 16.6 25.6 2.3 2 0 0 2 2 2 1 SDA1 AAA_19 PF13245.6 KOG97288.1 - 0.0077 16.6 0.9 0.035 14.5 0.0 2.5 3 0 0 3 3 3 1 AAA domain Nop14 PF04147.12 KOG97288.1 - 0.013 13.8 34.3 0.0075 14.5 26.1 2.3 2 0 0 2 2 2 0 Nop14-like family NACHT PF05729.12 KOG97288.1 - 0.025 14.5 0.0 0.19 11.6 0.0 2.4 2 1 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 KOG97288.1 - 0.047 14.1 0.1 0.89 10.0 0.0 3.0 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 KOG97288.1 - 0.072 13.6 0.0 0.072 13.6 0.0 3.8 3 2 2 5 5 5 0 AAA domain AAA_3 PF07726.11 KOG97288.1 - 0.13 12.1 0.1 0.64 9.9 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) BUD22 PF09073.10 KOG97288.1 - 0.16 11.3 43.2 0.23 10.8 34.7 2.4 2 0 0 2 2 2 0 BUD22 TFIIF_alpha PF05793.12 KOG97288.1 - 0.29 9.7 41.0 0.0052 15.4 31.0 2.2 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AAA_11 PF13086.6 KOG97288.1 - 1.5 8.6 0.0 1.5 8.6 0.0 3.4 4 0 0 4 4 4 0 AAA domain RBR PF17208.3 KOG97288.1 - 9.5 7.0 10.8 0.49 11.1 1.6 3.1 3 0 0 3 3 3 0 RNA binding Region Ras PF00071.22 KOG97289.1 - 6.4e-30 103.9 0.1 7.8e-30 103.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG97289.1 - 1.5e-20 73.6 0.0 2.5e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KOG97289.1 - 4.8e-06 26.1 0.2 6.1e-06 25.8 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 KOG97289.1 - 8.8e-05 22.0 0.1 0.00011 21.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 KOG97289.1 - 0.0011 18.5 1.0 0.0024 17.4 0.1 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region DLIC PF05783.11 KOG97289.1 - 0.0036 16.2 0.3 0.17 10.7 0.0 2.2 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) MMR_HSR1 PF01926.23 KOG97289.1 - 0.012 15.6 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Ribosomal_S3Ae PF01015.18 KOG97290.1 - 4.7e-86 287.5 4.9 5.5e-86 287.3 4.9 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 KOG97290.1 - 0.052 13.1 0.0 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region ISAV_HA PF06215.11 KOG97290.1 - 0.072 12.2 0.1 0.086 12.0 0.1 1.2 1 0 0 1 1 1 0 Infectious salmon anaemia virus haemagglutinin SpoVIF PF14069.6 KOG97290.1 - 1 9.2 5.2 7.4 6.4 1.7 2.5 2 0 0 2 2 2 0 Stage VI sporulation protein F THOC7 PF05615.13 KOG97291.1 - 6.9e-07 29.6 0.3 6.9e-07 29.6 0.3 2.7 2 1 0 2 2 2 1 Tho complex subunit 7 PIF1 PF05970.14 KOG97292.1 - 2e-84 283.8 0.6 1.8e-63 214.9 0.0 2.4 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 KOG97292.1 - 1.8e-17 63.7 0.0 4.1e-17 62.5 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOG97292.1 - 9.5e-10 39.0 0.0 2e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOG97292.1 - 5.8e-05 23.4 0.0 0.00031 21.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 KOG97292.1 - 0.00018 21.0 0.1 0.00044 19.7 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Herpes_Helicase PF02689.14 KOG97292.1 - 0.0038 15.2 0.1 0.023 12.7 0.0 1.9 2 0 0 2 2 2 1 Helicase UvrD_C_2 PF13538.6 KOG97292.1 - 0.011 15.6 0.0 0.027 14.3 0.0 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_7 PF12775.7 KOG97292.1 - 0.021 14.4 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region T2SSE PF00437.20 KOG97292.1 - 0.11 11.5 0.0 0.25 10.4 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DEAD PF00270.29 KOG97292.1 - 0.12 12.1 0.1 9.8 5.9 0.1 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase HhH-GPD PF00730.25 KOG97293.1 - 9e-23 80.8 0.0 1.7e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein OGG_N PF07934.12 KOG97293.1 - 1.8e-22 79.7 0.2 5.6e-22 78.1 0.1 1.9 2 0 0 2 2 2 1 8-oxoguanine DNA glycosylase, N-terminal domain cNMP_binding PF00027.29 KOG97294.1 - 8.5e-26 89.9 0.6 2.5e-13 49.9 0.0 5.4 5 1 0 5 5 5 2 Cyclic nucleotide-binding domain Patatin PF01734.22 KOG97294.1 - 2.6e-18 66.9 2.9 2.2e-16 60.7 2.9 3.0 1 1 0 1 1 1 1 Patatin-like phospholipase CENP-B_dimeris PF09026.10 KOG97294.1 - 0.084 13.3 9.4 0.27 11.7 9.4 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CDT1 PF08839.11 KOG97294.1 - 0.14 12.5 1.2 1.5 9.1 0.1 2.4 2 0 0 2 2 2 0 DNA replication factor CDT1 like DNA_pol_phi PF04931.13 KOG97294.1 - 2.6 6.1 7.6 4.5 5.2 7.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 KOG97294.1 - 3.1 7.0 8.1 5.7 6.2 8.1 1.3 1 0 0 1 1 1 0 NOA36 protein DUF4611 PF15387.6 KOG97294.1 - 8.7 6.6 9.6 0.54 10.5 4.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Metallophos PF00149.28 KOG97297.1 - 5e-36 125.1 0.2 8.8e-36 124.3 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SPC25 PF06703.11 KOG97298.1 - 4.5e-38 130.6 3.2 5e-38 130.4 3.2 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Ac76 PF05814.11 KOG97298.1 - 0.019 14.9 0.2 0.019 14.9 0.2 1.8 2 0 0 2 2 2 0 Orf76 (Ac76) FMN_dh PF01070.18 KOG97299.1 - 1.5e-120 402.4 0.0 1.9e-120 402.1 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 KOG97299.1 - 8.1e-22 77.2 0.0 2.1e-21 75.8 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 KOG97299.1 - 2e-08 33.8 0.0 3.6e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 KOG97299.1 - 0.00016 20.8 0.2 0.0035 16.4 0.0 2.6 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 KOG97299.1 - 0.0023 17.4 0.0 0.0035 16.8 0.0 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase Phage_Gp111 PF07410.11 KOG97299.1 - 0.12 12.8 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 Streptococcus thermophilus bacteriophage Gp111 protein ThiG PF05690.14 KOG97299.1 - 0.15 11.4 0.2 3 7.1 0.1 2.2 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG SUR7 PF06687.12 KOG97301.1 - 1.1e-38 133.0 12.0 1.5e-38 132.5 12.0 1.2 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 KOG97301.1 - 3.1e-07 30.5 5.7 6.6e-07 29.4 5.7 1.5 1 0 0 1 1 1 1 Ca2+ regulator and membrane fusion protein Fig1 DUF805 PF05656.14 KOG97301.1 - 1 9.8 11.2 0.11 13.0 6.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF805) Lig_chan PF00060.26 KOG97301.1 - 7.4 6.4 7.1 43 3.9 0.2 2.2 1 1 1 2 2 2 0 Ligand-gated ion channel GFO_IDH_MocA PF01408.22 KOG97302.1 - 8.2e-08 33.1 0.0 1.2e-07 32.6 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Suc_Fer-like PF06999.12 KOG97303.1 - 4.7e-31 108.2 0.0 5.8e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like MMS1_N PF10433.9 KOG97304.1 - 8e-78 262.2 8.6 8e-78 262.2 8.6 2.7 3 1 0 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 KOG97304.1 - 2.6e-45 155.2 0.2 1.6e-44 152.5 0.0 2.4 2 1 0 2 2 2 1 CPSF A subunit region BBS2_N PF14781.6 KOG97304.1 - 0.0051 16.7 1.3 0.15 11.9 0.1 3.4 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, N-terminal CDV3 PF15359.6 KOG97304.1 - 0.13 12.7 4.0 1.3 9.5 0.2 2.4 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 eIF3g PF12353.8 KOG97304.1 - 0.17 12.3 0.5 0.65 10.4 0.1 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G Voldacs PF03517.13 KOG97304.1 - 0.44 10.7 4.6 16 5.7 0.3 3.3 3 0 0 3 3 3 0 Regulator of volume decrease after cellular swelling E7 PF00527.18 KOG97304.1 - 7.8 6.8 9.0 4 7.7 0.7 3.2 3 0 0 3 3 3 0 E7 protein, Early protein Gsf2 PF11055.8 KOG97305.1 - 2.2e-174 579.6 0.0 3.2e-174 579.0 0.0 1.2 1 0 0 1 1 1 1 Glucose signalling factor 2 KCH PF16944.5 KOG97306.1 - 3.1e-77 259.8 18.4 3.6e-77 259.5 18.4 1.0 1 0 0 1 1 1 1 Fungal potassium channel Pex24p PF06398.11 KOG97306.1 - 0.083 11.9 7.6 0.29 10.1 7.5 2.0 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF2400 PF09674.10 KOG97307.1 - 0.026 14.5 0.4 0.065 13.2 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) RNA_pol_I_TF PF04090.12 KOG97308.1 - 8.3e-76 253.9 3.9 8.7e-76 253.9 2.3 1.9 2 0 0 2 2 2 1 RNA polymerase I specific initiation factor Carn_acyltransf PF00755.20 KOG97309.1 - 6.3e-181 603.0 0.0 7.3e-181 602.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase zf-HIT PF04438.16 KOG97310.1 - 0.013 15.4 9.8 0.023 14.6 9.8 1.4 1 0 0 1 1 1 0 HIT zinc finger FAST_2 PF08368.12 KOG97310.1 - 0.11 13.2 0.1 2.9 8.7 0.0 2.4 1 1 1 2 2 2 0 FAST kinase-like protein, subdomain 2 NRDD PF13597.6 KOG97310.1 - 0.23 10.2 2.4 0.35 9.6 2.4 1.2 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase TPT PF03151.16 KOG97311.1 - 1.5e-16 60.6 13.6 4.8e-09 36.0 5.5 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.11 KOG97311.1 - 1.1e-07 31.4 10.2 1.2e-07 31.2 1.5 2.2 2 0 0 2 2 2 2 UAA transporter family PUNUT PF16913.5 KOG97311.1 - 5.5e-07 29.1 1.0 5.5e-07 29.1 1.0 2.0 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport EamA PF00892.20 KOG97311.1 - 1.3e-05 25.4 32.6 0.052 13.7 12.9 4.0 3 2 0 3 3 3 2 EamA-like transporter family SLC35F PF06027.12 KOG97311.1 - 0.00083 19.0 1.7 0.00083 19.0 1.7 2.0 2 0 0 2 2 2 1 Solute carrier family 35 TMEM234 PF10639.9 KOG97311.1 - 0.02 14.9 8.8 0.97 9.5 1.4 2.4 2 0 0 2 2 2 0 Putative transmembrane family 234 EmrE PF13536.6 KOG97311.1 - 0.3 10.7 7.7 3.5 7.1 1.9 2.5 2 0 0 2 2 2 0 Putative multidrug resistance efflux transporter CGI-121 PF08617.10 KOG97313.1 - 1.8e-27 96.4 0.1 2e-27 96.3 0.1 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Skp1 PF01466.19 KOG97313.1 - 0.12 12.5 0.1 2 8.6 0.0 2.3 2 1 0 2 2 2 0 Skp1 family, dimerisation domain A_deaminase PF00962.22 KOG97314.1 - 6e-132 439.9 0.0 1.1e-131 439.1 0.0 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase MSC PF09402.10 KOG97315.1 - 7.2e-47 160.5 2.4 8.3e-47 160.3 2.4 1.0 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain NPIP PF06409.11 KOG97315.1 - 0.0098 15.0 1.0 0.013 14.6 1.0 1.1 1 0 0 1 1 1 1 Nuclear pore complex interacting protein (NPIP) BACK PF07707.15 KOG97315.1 - 0.018 15.2 0.4 0.032 14.3 0.4 1.3 1 0 0 1 1 1 0 BTB And C-terminal Kelch KN17_SH3 PF18131.1 KOG97315.1 - 0.02 15.0 0.5 0.048 13.8 0.5 1.6 1 0 0 1 1 1 0 KN17 SH3-like C-terminal domain Mlp PF03304.13 KOG97315.1 - 0.071 13.3 3.4 0.051 13.8 1.1 1.8 2 0 0 2 2 2 0 Mlp lipoprotein family Rad52_Rad22 PF04098.15 KOG97316.1 - 1.1e-54 184.5 0.0 1.9e-54 183.7 0.0 1.4 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Ndc1_Nup PF09531.10 KOG97317.1 - 3.7e-106 356.2 5.6 4.4e-106 356.0 5.6 1.1 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup HIG_1_N PF04588.13 KOG97318.1 - 3.2e-16 59.3 1.1 4.2e-16 58.9 1.1 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region FapA PF03961.13 KOG97318.1 - 0.042 12.5 1.8 0.04 12.5 1.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4200 PF13863.6 KOG97318.1 - 0.58 10.6 17.5 0.85 10.0 17.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) ubiquitin PF00240.23 KOG97319.1 - 4.6e-05 23.1 0.1 0.00025 20.8 0.1 2.3 2 0 0 2 2 2 1 Ubiquitin family DUF2407 PF10302.9 KOG97319.1 - 0.012 16.1 0.0 0.035 14.6 0.0 1.8 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 KOG97319.1 - 0.013 15.3 0.0 0.063 13.1 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 KOG97319.1 - 0.017 15.3 0.0 0.038 14.1 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF1031 PF06275.11 KOG97319.1 - 0.044 14.0 0.4 0.46 10.8 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1031) AhpC-TSA PF00578.21 KOG97320.1 - 4.3e-35 120.3 0.0 1.7e-34 118.4 0.0 1.8 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 KOG97320.1 - 2.8e-18 66.1 0.0 5.9e-18 65.0 0.0 1.5 2 0 0 2 2 2 1 Redoxin 1-cysPrx_C PF10417.9 KOG97320.1 - 5e-10 39.1 0.2 9.5e-10 38.2 0.2 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 KOG97320.1 - 0.01 15.7 0.1 0.018 15.0 0.1 1.5 1 0 0 1 1 1 0 SCO1/SenC Homeodomain PF00046.29 KOG97321.1 - 3.1e-16 58.9 4.5 3.1e-16 58.9 4.5 2.0 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KOG97321.1 - 3e-06 27.0 0.6 0.00017 21.4 0.1 3.5 4 0 0 4 4 4 1 Homeobox KN domain Ribosomal_S13 PF00416.22 KOG97322.1 - 1.1e-31 109.9 1.5 1.2e-31 109.7 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 CDPS PF16715.5 KOG97322.1 - 0.11 12.2 0.0 0.11 12.1 0.0 1.0 1 0 0 1 1 1 0 Cyclodipeptide synthase Ribosomal_L4 PF00573.22 KOG97323.1 - 7.3e-35 120.4 0.0 9.2e-35 120.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Terminase_3C PF17288.2 KOG97323.1 - 0.061 13.7 0.0 0.073 13.5 0.0 1.2 1 0 0 1 1 1 0 Terminase RNAseH like domain Ribosomal_S17e PF00833.18 KOG97324.1 - 1.2e-56 189.9 0.4 1.4e-56 189.7 0.4 1.1 1 0 0 1 1 1 1 Ribosomal S17 Nse5 PF08691.10 KOG97325.1 - 3.3e-154 514.4 12.6 3.9e-154 514.1 12.6 1.0 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 Pribosyltran PF00156.27 KOG97326.1 - 2.9e-14 52.9 0.0 3.9e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KOG97326.1 - 0.01 15.3 0.0 0.014 14.8 0.0 1.1 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase UDG PF03167.19 KOG97327.1 - 2.4e-21 76.3 0.1 4e-21 75.6 0.1 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Peptidase_S15 PF02129.18 KOG97328.1 - 0.061 12.9 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) OST3_OST6 PF04756.13 KOG97329.1 - 1.6e-69 234.5 5.4 1.9e-69 234.2 5.4 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Cyt_bd_oxida_I PF01654.17 KOG97329.1 - 0.002 16.9 0.4 0.003 16.2 0.4 1.3 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit I Psb28 PF03912.14 KOG97329.1 - 0.14 12.4 0.0 0.35 11.2 0.0 1.6 1 0 0 1 1 1 0 Psb28 protein UPF0242 PF06785.11 KOG97329.1 - 1.4 9.0 3.0 9.1 6.3 0.5 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF2070 PF09843.9 KOG97329.1 - 4.2 5.5 7.2 7.3 4.7 7.2 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) EamA PF00892.20 KOG97330.1 - 1.1e-09 38.6 32.1 1.7e-05 25.0 3.6 3.1 3 0 0 3 3 3 2 EamA-like transporter family DUF3955 PF13127.6 KOG97330.1 - 0.00087 19.1 2.8 0.00087 19.1 2.8 4.5 5 0 0 5 5 5 1 Protein of unknown function (DUF3955) Metallophos PF00149.28 KOG97332.1 - 4.7e-36 125.2 0.7 1.1e-35 124.1 0.2 1.9 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KOG97332.1 - 7.4e-19 67.9 0.6 1.5e-18 66.9 0.6 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain TAFII28 PF04719.14 KOG97333.1 - 2.9e-26 91.4 3.6 2.2e-23 82.2 0.4 2.9 3 0 0 3 3 3 2 hTAFII28-like protein conserved region Methyltransf_11 PF08241.12 KOG97334.1 - 2.2e-10 41.0 0.0 4.2e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOG97334.1 - 5e-09 36.8 0.0 9.7e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOG97334.1 - 4.6e-05 23.3 0.1 0.00021 21.1 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOG97334.1 - 0.0001 22.1 0.0 0.00018 21.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOG97334.1 - 0.00016 22.4 0.0 0.00041 21.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Cytochrom_C PF00034.21 KOG97334.1 - 0.18 13.0 1.2 0.6 11.3 0.2 2.1 2 0 0 2 2 2 0 Cytochrome c UBX PF00789.20 KOG97335.1 - 5.7e-09 36.0 0.1 2.9e-07 30.6 0.0 2.9 2 1 0 2 2 2 1 UBX domain UBA_4 PF14555.6 KOG97335.1 - 1.5e-08 34.3 0.0 3.8e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain DUF4335 PF14233.6 KOG97335.1 - 0.096 12.6 1.8 0.25 11.2 1.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4335) EMP24_GP25L PF01105.24 KOG97336.1 - 2e-41 142.0 0.0 2.3e-41 141.8 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TMEM191C PF15194.6 KOG97336.1 - 0.057 13.6 0.0 0.099 12.8 0.0 1.3 1 0 0 1 1 1 0 TMEM191C family Rad33 PF08730.10 KOG97337.1 - 3.2e-10 40.3 3.5 0.00012 22.1 0.2 2.3 1 1 1 2 2 2 2 Rad33 Spt5-NGN PF03439.13 KOG97338.1 - 2.8e-21 75.2 0.0 6.3e-21 74.1 0.0 1.7 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.8 KOG97338.1 - 6.8e-21 75.1 12.3 6.8e-21 75.1 12.3 3.3 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.29 KOG97338.1 - 1.4e-17 63.0 7.2 0.00037 20.3 0.4 4.7 4 0 0 4 4 4 4 KOW motif CTD PF12815.7 KOG97338.1 - 9.7e-05 22.9 22.0 9.7e-05 22.9 22.0 3.6 3 2 0 3 3 3 1 Spt5 C-terminal nonapeptide repeat binding Spt4 DUF3912 PF13051.6 KOG97338.1 - 0.00045 20.4 0.6 0.38 11.1 0.1 3.5 3 0 0 3 3 3 1 Protein of unknown function (DUF3912) Nucleo_P87 PF07267.11 KOG97338.1 - 0.04 12.8 24.4 0.073 11.9 24.4 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF150_C PF17384.2 KOG97338.1 - 0.13 12.4 0.3 2.1 8.5 0.3 2.6 2 0 0 2 2 2 0 RimP C-terminal SH3 domain Myosin_N PF02736.19 KOG97338.1 - 0.48 10.3 2.4 0.66 9.9 0.2 2.6 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain Hamartin PF04388.12 KOG97338.1 - 1.9 7.0 17.9 2.9 6.4 17.9 1.2 1 0 0 1 1 1 0 Hamartin protein CDC27 PF09507.10 KOG97338.1 - 3.5 6.9 35.0 6.3 6.1 35.0 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Ribosomal_L33 PF00471.20 KOG97339.1 - 0.00068 20.0 1.2 0.00085 19.7 0.1 1.9 2 1 0 2 2 2 1 Ribosomal protein L33 Sterol_MT_C PF08498.10 KOG97340.1 - 8.8e-26 90.0 1.5 1.5e-25 89.3 1.5 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 KOG97340.1 - 9.8e-20 71.0 0.0 2.3e-19 69.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOG97340.1 - 5.3e-18 65.5 0.0 1.2e-17 64.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOG97340.1 - 6.1e-16 58.6 0.1 1.1e-15 57.7 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOG97340.1 - 5.3e-13 48.9 0.5 7.4e-13 48.4 0.5 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 KOG97340.1 - 7.1e-13 48.7 0.0 1.2e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOG97340.1 - 2.1e-11 44.4 0.1 6.5e-11 42.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOG97340.1 - 7.1e-09 35.3 0.0 1.1e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.10 KOG97340.1 - 2.9e-06 26.9 0.3 7.8e-06 25.6 0.3 1.6 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 KOG97340.1 - 0.0044 16.5 0.1 0.014 14.8 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 KOG97340.1 - 0.0088 15.4 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_32 PF13679.6 KOG97340.1 - 0.015 15.3 0.3 0.04 13.9 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain PCMT PF01135.19 KOG97340.1 - 0.044 13.5 0.0 0.072 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.13 KOG97340.1 - 0.053 13.0 0.1 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 Histone methylation protein DOT1 MTS PF05175.14 KOG97340.1 - 0.094 12.3 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain UPF0020 PF01170.18 KOG97340.1 - 0.12 12.0 0.1 0.46 10.1 0.1 2.0 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 ADH_zinc_N PF00107.26 KOG97340.1 - 0.14 12.2 0.0 0.46 10.5 0.0 1.9 1 1 0 1 1 1 0 Zinc-binding dehydrogenase PAP1 PF08601.10 KOG97341.1 - 1e-19 71.5 1.7 1e-19 71.5 1.7 4.2 2 1 0 4 4 4 2 Transcription factor PAP1 bZIP_1 PF00170.21 KOG97341.1 - 2.1e-07 30.9 6.3 5.9e-07 29.5 6.3 1.8 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KOG97341.1 - 0.0045 17.0 12.0 0.0046 17.0 9.6 2.2 1 1 1 2 2 2 1 Basic region leucine zipper Met_10 PF02475.16 KOG97343.1 - 1.6e-09 37.8 0.0 3.6e-09 36.6 0.0 1.5 2 0 0 2 2 2 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 KOG97343.1 - 0.0074 16.0 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 KOG97343.1 - 0.011 15.3 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Glyoxalase PF00903.25 KOG97344.1 - 2.6e-38 131.1 0.0 8e-22 77.8 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 KOG97344.1 - 2.3e-13 50.4 0.0 4.6e-08 33.3 0.0 3.3 1 1 2 3 3 3 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 KOG97344.1 - 1e-05 26.3 0.0 0.036 14.9 0.0 2.8 2 2 0 2 2 2 2 Glyoxalase-like domain CppA_N PF14506.6 KOG97344.1 - 3.6e-05 23.8 0.1 0.061 13.4 0.1 2.4 2 0 0 2 2 2 2 CppA N-terminal Glyoxalase_3 PF13468.6 KOG97344.1 - 0.00023 21.4 0.0 0.13 12.3 0.0 3.6 3 1 0 3 3 3 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 KOG97344.1 - 0.00086 19.2 0.5 5.9 6.9 0.0 3.8 4 0 0 4 4 4 2 Glyoxalase-like domain VPS9 PF02204.18 KOG97345.1 - 2.1e-13 50.3 3.2 3.1e-13 49.8 0.9 2.4 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 KOG97345.1 - 0.00038 20.7 0.1 2.5 8.5 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOG97345.1 - 0.00097 19.7 1.3 0.95 10.1 0.0 3.9 1 1 2 3 3 3 1 Ankyrin repeats (3 copies) Ras PF00071.22 KOG97346.1 - 8.5e-47 158.8 0.3 1e-46 158.5 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG97346.1 - 9.8e-24 83.9 0.1 1.8e-23 83.0 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG97346.1 - 1.5e-09 37.6 0.0 1.7e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOG97346.1 - 9.8e-05 22.0 0.1 0.00014 21.5 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KOG97346.1 - 0.0024 17.3 0.1 0.0028 17.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Pkinase PF00069.25 KOG97347.1 - 1.6e-75 253.9 0.0 2.5e-75 253.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97347.1 - 4.9e-40 137.5 0.0 8.3e-40 136.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 KOG97347.1 - 2.4e-29 101.3 0.0 3.5e-16 59.1 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 KOG97347.1 - 8.2e-08 31.9 0.0 1.7e-05 24.3 0.0 2.7 3 0 0 3 3 3 2 Kinase-like SH3_3 PF08239.11 KOG97347.1 - 0.0016 18.7 0.1 0.0043 17.3 0.1 1.7 2 0 0 2 2 2 1 Bacterial SH3 domain Kdo PF06293.14 KOG97347.1 - 0.012 15.0 0.0 0.027 13.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KOG97347.1 - 0.04 12.9 0.8 0.06 12.3 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain DUF2076 PF09849.9 KOG97348.1 - 1.7e-06 28.3 8.7 2.1e-06 28.0 8.7 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 KOG97348.1 - 9.6e-05 22.4 5.0 0.00015 21.8 5.0 1.3 1 0 0 1 1 1 1 CHCH domain TMEM65 PF10507.9 KOG97348.1 - 0.032 14.2 1.4 0.032 14.2 1.4 1.5 2 0 0 2 2 2 0 Transmembrane protein 65 CX9C PF16860.5 KOG97348.1 - 2 8.5 7.6 0.11 12.6 2.4 1.6 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, SAP PF02037.27 KOG97349.1 - 2.1e-10 40.1 0.6 3.5e-10 39.4 0.6 1.4 1 0 0 1 1 1 1 SAP domain PX PF00787.24 KOG97350.1 - 4.2e-22 78.3 1.0 9.5e-22 77.1 0.1 2.0 2 0 0 2 2 2 1 PX domain TAF4 PF05236.14 KOG97351.1 - 2.4e-58 198.1 3.9 2.4e-58 198.1 3.9 2.1 2 0 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family TFIID_30kDa PF03540.13 KOG97351.1 - 0.0071 16.3 0.0 0.02 14.9 0.0 1.8 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Histone PF00125.24 KOG97351.1 - 6.1 7.2 10.8 0.81 10.1 0.1 3.1 2 2 1 3 3 3 0 Core histone H2A/H2B/H3/H4 PLA2_B PF01735.18 KOG97352.1 - 1.2e-224 746.3 4.0 1.2e-224 746.3 4.0 1.3 2 0 0 2 2 2 1 Lysophospholipase catalytic domain IBR PF01485.21 KOG97352.1 - 0.032 14.4 0.7 0.068 13.4 0.7 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Apt1 PF10351.9 KOG97352.1 - 1.3 7.8 6.8 1.8 7.3 6.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain PLA2_B PF01735.18 KOG97353.1 - 8.7e-229 759.9 3.6 1.1e-228 759.6 3.6 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain IBR PF01485.21 KOG97353.1 - 0.02 15.1 0.7 0.037 14.2 0.7 1.3 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain ARD PF03079.14 KOG97354.1 - 6.4e-50 169.4 0.2 7.4e-50 169.2 0.2 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 KOG97354.1 - 3e-11 42.9 0.0 4.8e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 KOG97354.1 - 2.1e-08 34.2 0.0 3.4e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 KOG97354.1 - 0.0017 17.9 0.0 0.0023 17.6 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_8 PF13621.6 KOG97354.1 - 0.011 15.5 0.0 0.033 13.9 0.0 1.6 1 1 1 2 2 2 0 Cupin-like domain Cupin_3 PF05899.12 KOG97354.1 - 0.1 12.3 0.0 0.31 10.8 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF861) Cupin_6 PF12852.7 KOG97354.1 - 0.23 11.2 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 Cupin PQ-loop PF04193.14 KOG97355.1 - 1.2e-13 50.6 7.7 7.3e-11 41.7 2.6 3.1 2 0 0 2 2 2 2 PQ loop repeat CLU PF13236.6 KOG97356.1 - 3.4e-64 216.7 0.3 7.6e-64 215.6 0.3 1.6 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 KOG97356.1 - 2e-33 115.9 0.3 2.6e-32 112.3 0.0 3.1 3 1 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.6 KOG97356.1 - 3.5e-22 78.6 0.1 1.6e-21 76.5 0.1 2.3 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.6 KOG97356.1 - 4.1e-07 30.2 1.6 0.00036 20.7 0.1 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOG97356.1 - 0.0025 17.6 0.5 0.064 13.2 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOG97356.1 - 0.0033 17.2 2.3 3.6 7.6 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF727 PF05303.12 KOG97356.1 - 0.0048 17.0 0.1 0.038 14.1 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF727) DUF2408 PF10303.9 KOG97356.1 - 0.028 15.0 8.0 0.49 11.0 1.2 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2408) RE_MjaI PF09568.10 KOG97356.1 - 0.032 14.1 4.1 0.1 12.4 4.1 1.9 1 0 0 1 1 1 0 MjaI restriction endonuclease CbiG_N PF11760.8 KOG97356.1 - 0.033 14.2 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 Cobalamin synthesis G N-terminal TPR_2 PF07719.17 KOG97356.1 - 1.7 9.0 3.7 5.7 7.3 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat SEO_N PF14576.6 KOG97357.1 - 0.092 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Sieve element occlusion N-terminus BUD22 PF09073.10 KOG97358.1 - 1.9e-78 264.7 44.2 2.9e-78 264.2 44.2 1.3 1 0 0 1 1 1 1 BUD22 DUF3440 PF11922.8 KOG97358.1 - 0.96 9.1 6.8 0.084 12.6 1.2 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3440) p450 PF00067.22 KOG97359.1 - 5e-54 183.8 0.1 6.5e-54 183.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 KilA-N PF04383.13 KOG97360.1 - 5e-05 23.1 0.1 0.00088 19.1 0.1 2.7 1 1 0 1 1 1 1 KilA-N domain TPR_2 PF07719.17 KOG97362.1 - 6.9e-11 41.4 0.5 0.14 12.4 0.1 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOG97362.1 - 1.2e-09 38.6 0.0 0.0035 17.8 0.0 4.2 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOG97362.1 - 7.5e-09 35.4 7.5 0.15 12.5 0.0 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOG97362.1 - 1.2e-08 34.5 6.1 0.084 13.1 0.1 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOG97362.1 - 4e-08 32.8 2.4 0.01 15.5 0.2 4.2 3 1 1 4 4 4 2 TPR repeat TPR_1 PF00515.28 KOG97362.1 - 1.5e-07 30.9 5.3 0.59 10.1 0.0 5.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOG97362.1 - 1.3e-06 28.7 0.0 0.17 12.8 0.0 4.3 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 KOG97362.1 - 1.4e-05 25.3 0.3 0.91 9.9 0.1 3.9 1 1 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOG97362.1 - 1.8e-05 25.3 0.0 1.8 9.2 0.0 4.1 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOG97362.1 - 0.019 15.1 0.0 4.4 7.5 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.6 KOG97362.1 - 0.036 13.3 0.7 0.66 9.1 0.2 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOG97362.1 - 0.042 14.5 0.0 23 5.9 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOG97362.1 - 0.083 13.2 1.3 1.9 8.9 0.2 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOG97362.1 - 0.17 11.8 0.2 7 6.7 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOG97362.1 - 1.3 9.3 4.3 1.2 9.4 0.4 2.7 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Fungal_trans PF04082.18 KOG97363.1 - 2.4e-24 85.8 11.8 6.5e-24 84.4 11.8 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG97363.1 - 3.4e-08 33.5 16.0 3.4e-08 33.5 16.0 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amino_oxidase PF01593.24 KOG97364.1 - 9e-77 259.3 0.0 1.1e-76 259.0 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOG97364.1 - 1.2e-12 47.8 0.2 2.4e-12 46.9 0.2 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KOG97364.1 - 3.2e-06 26.6 0.0 0.0004 19.7 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOG97364.1 - 9.1e-06 25.1 0.2 0.001 18.4 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOG97364.1 - 1.9e-05 24.0 0.6 2.7e-05 23.4 0.6 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 KOG97364.1 - 0.00016 21.1 0.2 0.00024 20.5 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOG97364.1 - 0.00032 20.4 2.4 0.0015 18.2 2.4 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOG97364.1 - 0.00088 18.1 0.2 0.021 13.5 0.2 2.1 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 KOG97364.1 - 0.0033 16.5 0.0 0.44 9.5 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 KOG97364.1 - 0.01 15.1 0.2 0.02 14.2 0.2 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 KOG97364.1 - 0.011 16.3 1.0 0.098 13.2 0.2 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOG97364.1 - 0.018 14.1 1.3 0.02 14.0 0.4 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Shikimate_DH PF01488.20 KOG97364.1 - 0.029 14.4 0.4 0.29 11.2 0.2 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 KOG97364.1 - 0.037 13.3 0.1 0.065 12.5 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 KOG97364.1 - 0.064 12.6 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 KOG97364.1 - 0.15 12.1 0.3 22 5.0 0.0 2.6 2 1 0 2 2 2 0 FAD-NAD(P)-binding Copper-fist PF00649.18 KOG97365.1 - 1e-19 69.7 4.1 2.7e-19 68.4 4.1 1.8 1 0 0 1 1 1 1 Copper fist DNA binding domain Myc_target_1 PF15179.6 KOG97365.1 - 0.1 12.5 2.2 0.2 11.5 2.2 1.4 1 0 0 1 1 1 0 Myc target protein 1 UQ_con PF00179.26 KOG97366.1 - 6.5e-49 165.2 0.0 7.4e-49 165.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOG97366.1 - 0.08 13.2 2.0 0.27 11.5 1.2 2.2 2 1 0 2 2 2 0 RWD domain MnmE_helical PF12631.7 KOG97367.1 - 1.5e-43 149.4 1.5 1.9e-43 149.1 1.5 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 KOG97367.1 - 2.6e-32 111.6 0.0 6.9e-32 110.2 0.0 1.8 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 KOG97367.1 - 9.2e-24 83.7 0.6 2.9e-23 82.1 0.1 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOG97367.1 - 1.7e-15 56.9 0.2 3.2e-15 56.0 0.2 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KOG97367.1 - 9.3e-11 41.9 0.2 2.3e-05 24.3 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Ras PF00071.22 KOG97367.1 - 3.5e-07 30.0 0.0 6.9e-07 29.0 0.0 1.5 1 1 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 KOG97367.1 - 2.6e-05 23.8 0.1 0.00031 20.3 0.1 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 KOG97367.1 - 0.00028 20.7 0.0 0.025 14.3 0.0 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 KOG97367.1 - 0.00036 20.7 0.0 0.0033 17.6 0.0 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG97367.1 - 0.00084 18.8 0.1 0.0065 15.9 0.1 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family Dynamin_N PF00350.23 KOG97367.1 - 0.0019 18.3 0.2 0.0072 16.4 0.1 2.1 2 0 0 2 2 2 1 Dynamin family cobW PF02492.19 KOG97367.1 - 0.0061 16.2 0.4 0.021 14.4 0.1 1.9 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1_Xtn PF16897.5 KOG97367.1 - 0.0092 16.0 0.0 0.036 14.1 0.0 2.0 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain AIG1 PF04548.16 KOG97367.1 - 0.036 13.4 3.4 0.07 12.4 0.2 2.7 2 1 1 3 3 3 0 AIG1 family MeaB PF03308.16 KOG97367.1 - 0.038 13.0 0.1 3.2 6.7 0.0 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 KOG97367.1 - 0.19 12.0 0.0 0.38 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain dsrm PF00035.26 KOG97368.1 - 1.9e-07 31.7 0.0 3.9e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 KOG97368.1 - 3.4e-05 24.4 0.1 0.00011 22.8 0.0 2.0 2 1 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 KOG97368.1 - 0.0084 16.3 0.1 0.03 14.5 0.1 1.8 1 1 0 1 1 1 1 Ribonuclease-III-like RcsD_ABL PF16359.5 KOG97369.1 - 0.04 14.1 2.9 0.11 12.7 2.9 1.7 1 0 0 1 1 1 0 RcsD-ABL domain Pex2_Pex12 PF04757.14 KOG97370.1 - 3.3e-44 151.2 9.7 4e-44 150.9 9.7 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 KOG97370.1 - 6.9e-06 25.8 2.9 1.2e-05 25.0 2.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOG97370.1 - 0.0012 18.6 4.2 0.0021 17.9 4.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KOG97370.1 - 0.016 15.4 7.6 0.03 14.5 7.6 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KOG97370.1 - 0.55 10.6 3.7 1 9.7 3.7 1.4 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 KOG97370.1 - 0.78 9.8 5.7 2 8.5 5.7 1.7 1 0 0 1 1 1 0 RING-type zinc-finger DUF89 PF01937.19 KOG97371.1 - 1.4e-114 382.7 2.8 1.6e-114 382.5 2.8 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 TAP42 PF04177.12 KOG97372.1 - 7e-81 271.8 13.9 7.9e-81 271.6 13.9 1.0 1 0 0 1 1 1 1 TAP42-like family Striatin PF08232.12 KOG97373.1 - 1.8e-21 77.4 2.6 1.7e-20 74.2 0.8 2.4 1 1 1 2 2 2 1 Striatin family Mto2_bdg PF12808.7 KOG97373.1 - 0.00035 20.8 1.6 0.00068 19.9 1.6 1.5 1 0 0 1 1 1 1 Micro-tubular organiser Mto1 C-term Mto2-binding region Ax_dynein_light PF10211.9 KOG97373.1 - 0.015 15.3 2.9 0.025 14.5 2.9 1.3 1 0 0 1 1 1 0 Axonemal dynein light chain Herpes_BLRF2 PF05812.12 KOG97373.1 - 0.075 13.2 0.6 0.16 12.1 0.6 1.6 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Jnk-SapK_ap_N PF09744.9 KOG97373.1 - 0.12 12.6 3.7 0.17 12.1 2.3 1.9 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 RSF PF14876.6 KOG97374.1 - 3e-190 632.1 15.0 3.7e-190 631.8 15.0 1.0 1 0 0 1 1 1 1 Respiratory growth transcriptional regulator Eisosome1 PF12757.7 KOG97375.1 - 3.2e-31 108.2 0.9 3.2e-31 108.2 0.9 4.7 4 1 0 4 4 4 1 Eisosome protein 1 AKNA PF12443.8 KOG97375.1 - 1.4 9.6 7.2 0.87 10.3 3.2 2.9 2 0 0 2 2 2 0 AT-hook-containing transcription factor FCH PF00611.23 KOG97376.1 - 1.3e-15 57.4 0.1 3.3e-14 52.9 0.0 3.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 KOG97376.1 - 0.00042 19.9 0.0 0.0011 18.5 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KOG97376.1 - 0.015 14.9 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain SH3_9 PF14604.6 KOG97376.1 - 0.047 13.5 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain DUF1835 PF08874.10 KOG97376.1 - 0.52 10.5 4.7 0.28 11.4 0.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1835) Cytochrom_B562 PF07361.11 KOG97376.1 - 1.3 9.7 21.0 0.7 10.6 3.7 4.1 4 1 1 5 5 5 0 Cytochrome b562 Actin PF00022.19 KOG97377.1 - 1.6e-20 73.1 0.0 2.4e-19 69.3 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 KOG97377.1 - 0.05 12.4 0.0 37 3.0 0.0 3.0 3 0 0 3 3 3 0 MreB/Mbl protein FtsA PF14450.6 KOG97377.1 - 0.12 12.8 0.0 0.32 11.4 0.0 1.8 1 1 0 1 1 1 0 Cell division protein FtsA DUF3391 PF11871.8 KOG97377.1 - 0.14 12.7 0.1 0.14 12.7 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) SBF_like PF13593.6 KOG97378.1 - 1.6e-118 395.6 14.3 1.8e-118 395.4 14.3 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 KOG97378.1 - 4.7e-11 42.7 8.6 8.9e-11 41.8 8.6 1.4 1 0 0 1 1 1 1 Sodium Bile acid symporter family Peptidase_S24 PF00717.23 KOG97379.1 - 8.8e-08 32.0 0.0 5.4e-07 29.5 0.0 2.2 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 KOG97379.1 - 0.00078 19.2 0.0 0.0037 17.1 0.0 1.9 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 Rhodanese PF00581.20 KOG97380.1 - 1.4e-10 41.6 0.0 3.4e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain CagY_I PF14585.6 KOG97380.1 - 0.16 12.1 3.5 1.1 9.4 3.5 2.5 1 0 0 1 1 1 0 CagY type 1 repeat zf-C2H2 PF00096.26 KOG97381.1 - 1.2e-11 44.4 18.2 6.6e-06 26.3 2.4 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOG97381.1 - 4.3e-07 30.1 20.4 1.6e-05 25.1 3.5 3.8 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KOG97381.1 - 2.9e-06 27.4 16.2 0.0022 18.2 5.6 2.9 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KOG97381.1 - 4.7e-06 27.0 24.3 0.00048 20.7 2.0 3.0 3 0 0 3 3 2 2 C2H2-type zinc finger zf-met PF12874.7 KOG97381.1 - 0.00013 22.2 11.7 0.084 13.3 2.2 2.9 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2HE PF16278.5 KOG97381.1 - 0.01 16.2 14.1 0.034 14.6 3.0 3.3 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger GAGA PF09237.11 KOG97381.1 - 0.011 15.5 2.7 1.3 8.9 0.4 2.6 1 1 1 2 2 2 0 GAGA factor zf-Di19 PF05605.12 KOG97381.1 - 0.058 13.7 8.5 0.15 12.4 8.5 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding 5-FTHF_cyc-lig PF01812.20 KOG97381.1 - 0.13 12.1 0.1 0.31 10.9 0.1 1.5 1 0 0 1 1 1 0 5-formyltetrahydrofolate cyclo-ligase family zf-C2H2_6 PF13912.6 KOG97381.1 - 0.17 11.9 16.2 0.21 11.6 4.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger DUF1631 PF07793.11 KOG97381.1 - 0.38 9.1 3.5 0.63 8.4 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) BolA PF01722.18 KOG97381.1 - 0.53 10.6 3.2 2.8 8.3 1.3 2.6 1 1 1 2 2 2 0 BolA-like protein zf-H2C2_5 PF13909.6 KOG97381.1 - 3.2 7.6 14.2 2.4 8.0 1.7 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF629 PF04780.12 KOG97381.1 - 3.6 6.0 12.9 3.2 6.2 3.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF629) HMA PF00403.26 KOG97382.1 - 5.4e-12 46.0 0.0 1.3e-11 44.7 0.0 1.7 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.20 KOG97382.1 - 3e-09 37.2 0.0 5e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) PC4 PF02229.16 KOG97383.1 - 6.2e-22 77.0 0.1 1e-21 76.3 0.1 1.4 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) Bap31 PF05529.12 KOG97384.1 - 7.9e-23 80.8 4.0 9.6e-23 80.5 4.0 1.1 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region UPF0239 PF06783.11 KOG97384.1 - 0.62 10.3 3.4 5.9 7.1 1.4 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) DUF2500 PF10694.9 KOG97384.1 - 1.1 9.8 6.3 0.33 11.5 0.4 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2500) DUF1656 PF07869.12 KOG97384.1 - 1.9 8.6 0.0 1.9 8.6 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1656) DUF3671 PF12420.8 KOG97384.1 - 2.3 8.3 10.4 81 3.3 10.4 2.3 1 1 0 1 1 1 0 Protein of unknown function Aldo_ket_red PF00248.21 KOG97385.1 - 9e-49 166.2 0.0 1.1e-48 165.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family SRF-TF PF00319.18 KOG97386.1 - 2.1e-20 71.9 0.1 3.2e-20 71.4 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Mucin PF01456.17 KOG97386.1 - 0.0021 18.1 7.8 0.003 17.5 7.8 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein CDC45 PF02724.14 KOG97386.1 - 0.036 12.4 0.0 0.041 12.2 0.0 1.0 1 0 0 1 1 1 0 CDC45-like protein eIF-3c_N PF05470.12 KOG97386.1 - 0.71 8.1 2.5 0.85 7.8 2.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF908 PF06012.12 KOG97386.1 - 2 7.7 8.6 2.6 7.3 8.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SSP160 PF06933.11 KOG97386.1 - 4.3 5.4 6.8 5.3 5.1 6.8 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 SRF-TF PF00319.18 KOG97387.1 - 4.3e-21 74.1 0.2 6.2e-21 73.6 0.2 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) SUIM_assoc PF16619.5 KOG97387.1 - 0.023 14.7 0.0 0.023 14.7 0.0 4.9 3 2 1 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 FAM176 PF14851.6 KOG97387.1 - 0.31 10.7 12.2 0.054 13.1 1.7 2.5 2 0 0 2 2 2 0 FAM176 family YL1 PF05764.13 KOG97387.1 - 0.42 10.7 25.7 0.03 14.4 20.5 1.7 2 0 0 2 2 2 0 YL1 nuclear protein Sporozoite_P67 PF05642.11 KOG97387.1 - 0.49 8.4 13.0 0.015 13.4 6.6 1.4 1 1 0 1 1 1 0 Sporozoite P67 surface antigen GREB1 PF15782.5 KOG97387.1 - 2.2 5.3 26.7 2.5 5.1 26.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CAC1F_C PF16885.5 KOG97387.1 - 3 7.4 22.8 4.4 6.9 22.8 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term CENP-B_dimeris PF09026.10 KOG97387.1 - 5 7.6 16.9 12 6.4 16.9 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2981 PF11200.8 KOG97387.1 - 7.1 6.3 10.0 8.8 6.0 10.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) SOG2 PF10428.9 KOG97387.1 - 7.8 5.6 19.3 10 5.2 19.3 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein PWWP PF00855.17 KOG97388.1 - 4.8e-20 71.8 0.2 4.8e-20 71.8 0.2 3.2 2 2 1 3 3 3 1 PWWP domain TFIIF_alpha PF05793.12 KOG97388.1 - 0.31 9.6 33.1 0.45 9.0 26.0 2.3 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) MCM_bind PF09739.9 KOG97388.1 - 0.4 9.1 10.0 0.55 8.6 10.0 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor PBP1_TM PF14812.6 KOG97388.1 - 0.67 10.4 34.4 0.069 13.5 13.6 4.1 3 1 1 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4551 PF15087.6 KOG97388.1 - 1.2 7.9 11.1 1.6 7.5 11.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) AF-4 PF05110.13 KOG97388.1 - 3.2 5.7 23.5 4.3 5.3 23.5 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Nucleo_P87 PF07267.11 KOG97388.1 - 9.6 4.9 14.2 17 4.1 14.2 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Nucleoporin2 PF04096.14 KOG97389.1 - 1e-40 139.3 0.0 2.6e-40 138.0 0.0 1.8 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 KOG97389.1 - 3.4e-34 117.6 330.3 1.1e-10 42.2 30.4 11.7 3 2 11 14 14 14 11 Nucleoporin FG repeat region Swi3 PF07962.12 KOG97390.1 - 1e-26 92.7 0.3 2.3e-26 91.6 0.1 1.7 2 0 0 2 2 2 1 Replication Fork Protection Component Swi3 HA PF03457.14 KOG97390.1 - 0.029 14.7 0.8 0.11 12.9 0.3 2.1 2 0 0 2 2 2 0 Helicase associated domain BOP1NT PF08145.12 KOG97391.1 - 4.3e-103 344.8 7.3 7.3e-103 344.0 7.3 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 KOG97391.1 - 3.5e-24 84.6 8.1 2.7e-09 37.5 0.2 6.8 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97391.1 - 4.7e-09 36.4 0.2 0.0014 18.9 0.0 4.9 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain DUP PF00674.18 KOG97392.1 - 2.1e-28 98.5 0.4 2.1e-28 98.5 0.4 1.8 1 1 1 2 2 2 1 DUP family OppC_N PF12911.7 KOG97392.1 - 5.2 7.1 7.5 1.9 8.5 1.1 2.3 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Epimerase PF01370.21 KOG97393.1 - 1.7e-15 57.1 0.0 5.2e-15 55.6 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOG97393.1 - 1.2e-09 37.6 0.0 2.8e-09 36.4 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 KOG97393.1 - 1.7e-08 34.6 0.0 3.1e-08 33.7 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 KOG97393.1 - 1.7e-07 31.0 0.3 1.1e-06 28.3 0.0 2.3 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 KOG97393.1 - 2.6e-06 27.1 0.1 4.5e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 KOG97393.1 - 3.1e-06 26.8 0.1 2.1e-05 24.1 0.1 2.1 2 0 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 KOG97393.1 - 2.3e-05 23.7 0.0 0.00011 21.4 0.0 1.9 1 1 0 1 1 1 1 RmlD substrate binding domain UDPG_MGDP_dh_N PF03721.14 KOG97393.1 - 0.0099 15.5 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 KOG97393.1 - 0.017 15.3 0.1 0.028 14.7 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 KOG97393.1 - 0.021 14.7 0.1 0.037 14.0 0.1 1.3 1 0 0 1 1 1 0 KR domain NAD_binding_4 PF07993.12 KOG97393.1 - 0.026 13.7 0.0 0.059 12.5 0.0 1.5 1 1 0 1 1 1 0 Male sterility protein TrkA_N PF02254.18 KOG97393.1 - 0.043 14.1 0.1 0.078 13.2 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain DapB_N PF01113.20 KOG97393.1 - 0.059 13.5 0.1 0.16 12.1 0.1 1.7 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus SAP30_Sin3_bdg PF13867.6 KOG97394.1 - 0.0097 16.2 1.0 0.54 10.6 0.0 2.5 2 0 0 2 2 2 2 Sin3 binding region of histone deacetylase complex subunit SAP30 RecG_N PF17190.4 KOG97394.1 - 1.4 9.7 9.2 0.91 10.3 3.0 2.7 3 0 0 3 3 3 0 RecG N-terminal helical domain Bul1_C PF04426.12 KOG97395.1 - 0.14 11.5 5.5 0.047 13.1 2.3 1.8 2 0 0 2 2 2 0 Bul1 C terminus DUF1664 PF07889.12 KOG97395.1 - 0.24 11.5 2.8 0.22 11.5 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) PHD PF00628.29 KOG97395.1 - 0.41 10.6 2.7 1 9.3 2.7 1.6 1 0 0 1 1 1 0 PHD-finger V_ATPase_I PF01496.19 KOG97396.1 - 5e-299 993.9 2.4 6.2e-299 993.6 2.4 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family KdpD PF02702.17 KOG97396.1 - 0.028 13.9 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 Osmosensitive K+ channel His kinase sensor domain CLZ PF16526.5 KOG97396.1 - 0.058 13.8 4.6 1.9 8.9 0.9 2.7 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Bcr-Abl_Oligo PF09036.10 KOG97396.1 - 0.15 12.1 1.1 0.41 10.7 1.1 1.7 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain DUF4618 PF15397.6 KOG97396.1 - 0.5 9.8 7.7 0.42 10.0 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) Snapin_Pallidin PF14712.6 KOG97396.1 - 1.8 9.0 6.5 18 5.8 0.6 3.0 3 0 0 3 3 3 0 Snapin/Pallidin BLOC1_2 PF10046.9 KOG97396.1 - 2.7 8.3 7.6 15 6.0 0.3 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.12 KOG97396.1 - 3.1 7.8 9.3 15 5.6 3.7 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 KOG97396.1 - 3.6 7.9 4.8 7.5 6.9 0.6 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) RabGAP-TBC PF00566.18 KOG97397.1 - 1.3e-36 126.3 1.1 1.9e-36 125.8 1.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain pPIWI_RE_Z PF18155.1 KOG97397.1 - 0.018 14.9 0.2 0.059 13.2 0.2 1.7 2 0 0 2 2 2 0 pPIWI RE three-gene island domain Z Mito_carr PF00153.27 KOG97398.1 - 1e-67 224.1 5.9 8.8e-24 83.3 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Cu-oxidase_2 PF07731.14 KOG97399.1 - 4e-48 162.6 6.1 7.1e-41 139.1 0.8 3.2 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 KOG97399.1 - 4.2e-44 149.4 6.5 4.7e-41 139.5 0.8 3.7 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.22 KOG97399.1 - 3.8e-35 121.4 10.0 5.3e-32 111.1 2.2 3.7 3 1 0 3 3 3 2 Multicopper oxidase Doppel PF11466.8 KOG97399.1 - 0.089 12.5 1.7 0.2 11.3 1.7 1.6 1 0 0 1 1 1 0 Prion-like protein Doppel Cupredoxin_1 PF13473.6 KOG97399.1 - 0.11 12.6 0.0 5.8 7.1 0.0 3.4 2 2 1 3 3 3 0 Cupredoxin-like domain Sen15 PF09631.10 KOG97400.1 - 1.1e-27 96.2 0.0 1.3e-27 96.0 0.0 1.0 1 0 0 1 1 1 1 Sen15 protein Tom37_C PF11801.8 KOG97401.1 - 3.1e-54 182.9 4.0 6.1e-54 182.0 4.0 1.4 1 0 0 1 1 1 1 Tom37 C-terminal domain Tom37 PF10568.9 KOG97401.1 - 1.8e-34 118.7 1.5 2.3e-34 118.4 0.1 1.8 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 KOG97401.1 - 0.011 16.5 0.5 0.049 14.4 0.0 2.4 3 1 0 3 3 3 0 Glutathione S-transferase N-terminal domain Suf PF05843.14 KOG97402.1 - 1.1e-67 229.2 21.8 2.5e-61 208.3 9.5 3.8 2 2 1 3 3 3 3 Suppressor of forked protein (Suf) ArgJ PF01960.18 KOG97403.1 - 1e-143 478.6 6.7 1.2e-143 478.4 6.7 1.0 1 0 0 1 1 1 1 ArgJ family SmAKAP PF15127.6 KOG97403.1 - 0.057 14.6 0.0 0.13 13.5 0.0 1.6 1 0 0 1 1 1 0 Small membrane A-kinase anchor protein SUR7 PF06687.12 KOG97404.1 - 5.7e-21 75.1 14.3 7.6e-21 74.7 14.3 1.1 1 0 0 1 1 1 1 SUR7/PalI family SIT PF15330.6 KOG97404.1 - 0.015 15.8 0.1 0.015 15.8 0.1 2.1 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Phage_holin_3_6 PF07332.11 KOG97404.1 - 0.043 13.9 1.1 0.043 13.9 1.1 1.8 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III ABC2_membrane PF01061.24 KOG97404.1 - 1.7 8.0 13.5 0.063 12.7 7.5 1.7 2 0 0 2 2 2 0 ABC-2 type transporter AEP1 PF17049.5 KOG97405.1 - 4.1e-112 375.1 16.3 5.6e-112 374.7 16.3 1.2 1 0 0 1 1 1 1 ATPase expression protein 1 SafA PF17073.5 KOG97405.1 - 0.0085 16.0 0.5 3.1 7.8 0.0 2.7 2 0 0 2 2 2 2 Two-component-system connector protein Carot_N PF09150.10 KOG97405.1 - 0.042 13.7 0.1 0.65 9.9 0.1 2.3 2 0 0 2 2 2 0 Orange carotenoid protein, N-terminal Eno-Rase_FAD_bd PF07055.12 KOG97405.1 - 0.085 13.3 0.1 0.22 12.0 0.1 1.6 1 0 0 1 1 1 0 Enoyl reductase FAD binding domain Tht1 PF04163.12 KOG97406.1 - 6.5e-147 490.6 23.3 1.1e-146 489.8 23.3 1.3 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein DUF4550 PF15084.6 KOG97406.1 - 0.0049 17.2 1.2 0.0049 17.2 1.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4550) Syntaxin-6_N PF09177.11 KOG97406.1 - 0.014 15.9 6.6 2.9 8.5 0.0 3.5 2 1 1 3 3 3 0 Syntaxin 6, N-terminal ApoLp-III PF07464.11 KOG97406.1 - 0.033 14.3 5.1 1.5 9.0 1.9 3.0 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) FlaC_arch PF05377.11 KOG97406.1 - 0.035 14.5 0.0 0.035 14.5 0.0 4.3 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Apolipoprotein PF01442.18 KOG97406.1 - 0.056 13.3 0.5 0.19 11.6 0.4 1.8 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF1451 PF07295.11 KOG97406.1 - 0.78 9.8 4.2 1.4 8.9 0.1 2.4 2 0 0 2 2 2 0 Zinc-ribbon containing domain DUF948 PF06103.11 KOG97406.1 - 2.5 8.4 5.2 66 3.9 0.0 3.7 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 KOG97406.1 - 9.7 6.3 8.4 29 4.7 2.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) TUG-UBL1 PF11470.8 KOG97408.1 - 5.1e-23 81.1 3.0 7.9e-23 80.5 0.8 2.5 3 0 0 3 3 3 1 TUG ubiquitin-like domain UBX PF00789.20 KOG97408.1 - 4.7e-17 61.9 0.1 1.6e-16 60.3 0.1 1.9 1 0 0 1 1 1 1 UBX domain RA PF00788.23 KOG97408.1 - 0.0051 17.4 0.4 0.055 14.1 0.0 2.5 3 0 0 3 3 3 1 Ras association (RalGDS/AF-6) domain SASP PF00269.20 KOG97408.1 - 0.055 13.5 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Small, acid-soluble spore proteins, alpha/beta type Ank_2 PF12796.7 KOG97409.1 - 2.3e-23 82.6 0.1 5.2e-09 36.6 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOG97409.1 - 1e-19 70.6 7.6 3.9e-10 40.0 0.4 3.8 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOG97409.1 - 3.2e-15 54.7 5.6 0.025 15.1 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 KOG97409.1 - 2e-14 53.3 8.4 0.0031 17.9 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 KOG97409.1 - 3e-11 43.3 0.8 0.00027 21.1 0.0 3.7 2 2 1 3 3 3 3 Ankyrin repeats (many copies) Acetyltransf_1 PF00583.25 KOG97410.1 - 9.3e-07 29.1 0.1 1.5e-06 28.4 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 KOG97410.1 - 2.2e-06 27.5 0.0 6.8e-06 26.0 0.0 1.8 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 KOG97410.1 - 6.1e-06 26.6 0.1 1.3e-05 25.6 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOG97410.1 - 0.022 14.7 0.0 0.094 12.7 0.0 2.1 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOG97410.1 - 0.026 14.6 0.1 0.15 12.2 0.1 2.2 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain zf-C2H2 PF00096.26 KOG97411.1 - 2.7e-05 24.4 12.4 0.00019 21.7 4.4 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG97411.1 - 0.00013 22.5 13.0 0.0054 17.5 4.8 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.12 KOG97411.1 - 0.00033 20.9 3.3 0.0007 19.8 3.3 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.15 KOG97411.1 - 0.061 13.3 7.2 0.071 13.1 0.6 3.2 2 0 0 2 2 2 0 BED zinc finger zf-H2C2_2 PF13465.6 KOG97411.1 - 0.076 13.5 14.3 0.66 10.5 0.7 3.4 3 0 0 3 3 3 0 Zinc-finger double domain zf-MYST PF17772.1 KOG97411.1 - 0.11 12.1 1.8 14 5.4 0.3 2.6 2 0 0 2 2 2 0 MYST family zinc finger domain SUIM_assoc PF16619.5 KOG97411.1 - 1.1 9.4 8.8 5.9 7.0 8.8 2.3 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 zf-H2C2_5 PF13909.6 KOG97411.1 - 1.3 8.8 17.6 3.6 7.4 4.4 2.9 2 1 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.7 KOG97411.1 - 4.8 7.6 14.0 0.88 9.9 0.9 3.1 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Cg6151-P PF10233.9 KOG97412.1 - 6.2e-39 132.8 14.9 7.5e-39 132.6 14.9 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P Gaa1 PF04114.14 KOG97412.1 - 0.008 15.2 0.2 0.012 14.7 0.2 1.2 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component ATG22 PF11700.8 KOG97412.1 - 0.018 13.7 7.7 0.022 13.4 7.7 1.0 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like Colicin PF01024.19 KOG97412.1 - 1.2 9.0 6.5 0.26 11.2 1.4 1.9 1 1 1 2 2 2 0 Colicin pore forming domain HMG_box PF00505.19 KOG97413.1 - 2.6e-34 117.5 4.3 3.2e-19 69.1 1.2 2.1 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 KOG97413.1 - 9.1e-17 61.4 2.9 4.8e-11 43.1 0.8 2.2 2 0 0 2 2 2 2 HMG-box domain CHDNT PF08073.12 KOG97413.1 - 5e-05 23.2 0.0 0.46 10.5 0.0 3.0 3 1 0 3 3 3 2 CHDNT (NUC034) domain Protamine_like PF06382.11 KOG97413.1 - 0.043 14.0 1.0 0.34 11.1 0.2 2.1 2 0 0 2 2 2 0 Protamine and protamine like BBP1_C PF15272.6 KOG97413.1 - 7.4 6.4 11.0 0.35 10.7 2.3 2.5 2 1 1 3 3 3 0 Spindle pole body component BBP1, C-terminal Cyt-b5 PF00173.28 KOG97414.1 - 8.8e-18 64.2 0.0 1.3e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain dsDNA_bind PF01984.20 KOG97415.1 - 4e-23 81.8 0.1 4.8e-23 81.6 0.1 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain EF-1_beta_acid PF10587.9 KOG97415.1 - 0.48 10.9 0.1 0.48 10.9 0.1 2.7 3 0 0 3 3 3 0 Eukaryotic elongation factor 1 beta central acidic region PHD PF00628.29 KOG97416.1 - 1.1e-13 50.9 24.4 1.1e-10 41.2 10.8 3.3 3 1 1 4 4 4 2 PHD-finger PHF12_MRG_bd PF16737.5 KOG97416.1 - 0.055 13.2 0.2 0.13 12.0 0.2 1.6 1 0 0 1 1 1 0 PHD finger protein 12 MRG binding domain C1_1 PF00130.22 KOG97416.1 - 0.25 11.3 17.1 0.67 9.9 1.0 3.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.6 KOG97416.1 - 2.5 7.7 12.2 5 6.8 0.3 3.6 3 0 0 3 3 3 0 PHD-finger Cnd1 PF12717.7 KOG97417.1 - 2.1e-06 27.9 11.1 2.3e-05 24.5 1.1 5.3 5 1 1 6 6 6 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KOG97417.1 - 0.0027 17.8 0.1 32 5.1 0.0 5.3 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.6 KOG97417.1 - 0.019 15.3 0.1 3.8 8.0 0.0 4.0 4 1 1 5 5 5 0 HEAT repeats Snf7 PF03357.21 KOG97418.1 - 1.1e-39 135.8 12.0 1.5e-39 135.4 12.0 1.2 1 0 0 1 1 1 1 Snf7 SlyX PF04102.12 KOG97418.1 - 0.0067 17.0 7.0 0.11 13.1 0.6 2.8 2 0 0 2 2 2 2 SlyX DUF948 PF06103.11 KOG97418.1 - 0.93 9.8 5.4 0.45 10.8 0.8 2.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Sec2p PF06428.11 KOG97418.1 - 2.6 8.1 16.2 0.71 9.9 1.2 4.0 1 1 3 4 4 4 0 GDP/GTP exchange factor Sec2p AAA PF00004.29 KOG97419.1 - 1.7e-11 44.7 0.4 1.6e-10 41.5 0.0 2.6 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 KOG97419.1 - 1.2e-06 28.6 1.8 2.9e-05 24.1 0.2 2.8 2 1 0 2 2 1 1 Rad17 P-loop domain RuvB_N PF05496.12 KOG97419.1 - 0.00012 21.9 0.0 0.00035 20.4 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOG97419.1 - 0.00045 20.6 0.0 0.0011 19.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 KOG97419.1 - 0.0041 17.3 0.1 0.056 13.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 KOG97419.1 - 0.011 16.1 0.0 0.035 14.4 0.0 1.9 1 0 0 1 1 1 0 AAA C-terminal domain AAA_22 PF13401.6 KOG97419.1 - 0.013 15.8 0.0 0.056 13.7 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_14 PF13173.6 KOG97419.1 - 0.021 14.9 0.0 0.064 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain Phage_Mu_Gam PF07352.12 KOG97419.1 - 0.021 14.7 0.1 0.45 10.4 0.0 2.7 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein AAA_18 PF13238.6 KOG97419.1 - 0.029 14.9 0.0 0.69 10.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 KOG97419.1 - 0.039 13.9 0.0 0.13 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 KOG97419.1 - 0.047 14.2 3.2 3.1 8.3 0.0 4.2 5 0 0 5 5 5 0 ABC transporter RNA_helicase PF00910.22 KOG97419.1 - 0.079 13.4 0.2 0.55 10.6 0.0 2.5 2 1 0 2 2 2 0 RNA helicase AAA_11 PF13086.6 KOG97419.1 - 0.31 10.8 0.0 0.31 10.8 0.0 2.4 2 1 0 2 2 2 0 AAA domain CRAL_TRIO PF00650.20 KOG97420.1 - 1e-36 126.1 0.0 1.4e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KOG97420.1 - 1e-09 38.4 0.4 2.4e-09 37.3 0.4 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 KOG97420.1 - 0.00091 19.4 0.0 0.0016 18.6 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain UPF1_Zn_bind PF09416.10 KOG97421.1 - 2.4e-64 215.9 7.8 2.4e-64 215.9 7.8 2.2 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 KOG97421.1 - 3.1e-57 193.4 0.0 6.3e-57 192.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOG97421.1 - 1.6e-49 169.1 3.9 1.2e-26 94.1 0.4 2.5 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 KOG97421.1 - 9.1e-27 93.1 0.0 2.1e-26 92.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 KOG97421.1 - 1.4e-17 64.0 0.1 2.7e-15 56.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOG97421.1 - 2.6e-13 50.5 0.1 5.2e-13 49.6 0.1 1.5 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 KOG97421.1 - 3e-05 23.7 0.4 0.018 14.6 0.0 3.0 2 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain DUF2075 PF09848.9 KOG97421.1 - 5e-05 22.7 0.1 0.0025 17.1 0.0 3.1 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 KOG97421.1 - 5.8e-05 22.9 0.0 0.62 9.8 0.0 2.9 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 KOG97421.1 - 0.0001 22.3 0.3 0.00029 20.9 0.0 1.9 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 KOG97421.1 - 0.003 17.4 0.0 0.0064 16.4 0.0 1.5 1 0 0 1 1 1 1 Helicase PIF1 PF05970.14 KOG97421.1 - 0.0049 16.1 0.0 0.74 8.9 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase PhoH PF02562.16 KOG97421.1 - 0.012 15.1 0.0 0.026 14.0 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.20 KOG97421.1 - 0.043 12.9 0.0 0.076 12.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein HEM4 PF02602.15 KOG97421.1 - 0.047 13.0 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD DEAD PF00270.29 KOG97421.1 - 0.074 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 KOG97421.1 - 0.11 12.7 0.0 0.27 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain zf-ribbon_3 PF13248.6 KOG97421.1 - 3.4 7.2 7.7 0.88 9.1 0.3 3.1 3 0 0 3 3 3 0 zinc-ribbon domain MBR1 PF17058.5 KOG97422.1 - 4.4e-39 134.9 12.5 4.4e-39 134.9 12.5 3.0 2 2 0 2 2 2 1 Mitochondrial biogenesis regulation protein 1 ADH_N PF08240.12 KOG97423.1 - 1.2e-29 102.3 0.2 2.3e-29 101.5 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOG97423.1 - 5.9e-24 84.5 0.2 9.1e-24 83.9 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOG97423.1 - 5.6e-06 27.4 0.0 9.6e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 KOG97423.1 - 0.051 13.0 0.1 0.092 12.2 0.1 1.4 1 0 0 1 1 1 0 short chain dehydrogenase Epimerase PF01370.21 KOG97423.1 - 0.08 12.4 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family SIS PF01380.22 KOG97424.1 - 3.8e-51 172.4 0.1 5.3e-28 97.5 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 KOG97424.1 - 1.1e-14 54.8 0.0 2.4e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KOG97424.1 - 6.4e-10 39.0 0.0 1.3e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 KOG97424.1 - 3.3e-05 22.9 0.1 5.6e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Macro_2 PF14519.6 KOG97426.1 - 9.3e-152 504.2 0.0 1.1e-151 503.9 0.0 1.0 1 0 0 1 1 1 1 Macro-like domain Macro PF01661.21 KOG97426.1 - 0.0034 17.4 0.0 0.0082 16.2 0.0 1.7 1 1 0 1 1 1 1 Macro domain MFS_1 PF07690.16 KOG97427.1 - 1.8e-40 138.9 38.6 4.7e-40 137.6 38.5 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG97427.1 - 8.8e-17 61.1 7.9 8.8e-17 61.1 7.9 3.3 3 1 0 3 3 3 1 Sugar (and other) transporter Peptidase_M41 PF01434.18 KOG97428.1 - 5.7e-68 228.5 1.3 3.1e-67 226.1 0.0 2.1 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 KOG97428.1 - 5.2e-42 143.4 0.0 1.3e-41 142.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG97428.1 - 4.9e-15 55.1 0.3 3.7e-14 52.3 0.1 2.6 3 0 0 3 3 3 1 AAA+ lid domain FtsH_ext PF06480.15 KOG97428.1 - 1.3e-09 38.4 0.5 3.6e-09 36.9 0.5 1.8 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 KOG97428.1 - 0.0016 18.5 0.0 0.0071 16.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KOG97428.1 - 0.002 17.9 0.0 0.0049 16.6 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 KOG97428.1 - 0.0025 17.1 0.5 0.0081 15.4 0.0 1.9 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_16 PF13191.6 KOG97428.1 - 0.0031 17.9 1.2 0.053 13.9 0.1 3.0 2 1 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 KOG97428.1 - 0.0037 17.4 0.1 0.014 15.5 0.0 2.0 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 KOG97428.1 - 0.005 17.3 2.5 0.0094 16.4 0.0 2.6 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 KOG97428.1 - 0.035 13.9 0.0 0.075 12.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.6 KOG97428.1 - 0.036 14.4 0.1 0.69 10.2 0.1 2.6 2 0 0 2 2 2 0 AAA domain DUF5100 PF17029.5 KOG97428.1 - 0.039 13.8 4.8 0.12 12.2 3.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5100) DUF2407_C PF13373.6 KOG97428.1 - 0.04 14.1 2.4 0.1 12.8 2.4 1.6 1 0 0 1 1 1 0 DUF2407 C-terminal domain AAA_33 PF13671.6 KOG97428.1 - 0.12 12.5 0.0 0.31 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain SMBP PF16785.5 KOG97428.1 - 0.23 11.7 1.8 0.6 10.4 1.8 1.7 1 0 0 1 1 1 0 Small metal-binding protein NAD_binding_10 PF13460.6 KOG97429.1 - 2.2e-48 164.6 0.0 2.5e-48 164.4 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOG97429.1 - 3.6e-10 39.8 0.2 2.7e-09 37.0 0.2 1.9 1 1 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 KOG97429.1 - 3.3e-08 32.9 1.4 4.6e-08 32.4 1.4 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KOG97429.1 - 9.4e-08 31.8 0.1 1.9e-07 30.8 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 KOG97429.1 - 5.8e-07 30.0 0.2 8.4e-07 29.4 0.2 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 KOG97429.1 - 9.2e-05 22.6 0.2 0.00017 21.7 0.2 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Ldh_1_N PF00056.23 KOG97429.1 - 0.00029 20.9 0.9 0.0004 20.5 0.9 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 KOG97429.1 - 0.0022 18.1 0.1 0.0038 17.3 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Glu_dehyd_C PF16912.5 KOG97429.1 - 0.029 13.9 0.1 0.04 13.4 0.1 1.2 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus GFO_IDH_MocA PF01408.22 KOG97429.1 - 0.029 15.2 0.1 0.095 13.5 0.0 1.8 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 KOG97429.1 - 0.031 14.8 0.1 0.084 13.5 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.15 KOG97429.1 - 0.066 12.3 1.2 0.2 10.8 1.2 1.7 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 KOG97429.1 - 0.091 11.8 0.2 0.16 11.1 0.2 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain CRC_subunit PF08624.10 KOG97430.1 - 2.2e-52 177.0 0.0 5.1e-52 175.9 0.0 1.6 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit CDC45 PF02724.14 KOG97430.1 - 1.2 7.3 13.7 1.6 6.9 13.7 1.1 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 KOG97431.1 - 2.2e-16 59.9 18.5 0.18 12.7 0.1 10.3 10 0 0 10 10 10 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97431.1 - 8.2e-09 35.6 0.8 1.6 9.1 0.1 6.9 3 3 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOG97431.1 - 2.8e-06 27.4 0.2 0.23 11.3 0.0 3.7 3 0 0 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KOG97431.1 - 0.014 14.1 0.4 0.06 12.0 0.4 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 RAB3GAP2_N PF14655.6 KOG97431.1 - 0.039 13.2 0.0 0.13 11.5 0.0 1.9 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus UTP15_C PF09384.10 KOG97432.1 - 5.8e-44 149.3 0.4 1e-43 148.6 0.4 1.4 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 KOG97432.1 - 1.6e-16 60.3 4.8 0.034 15.0 0.0 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97432.1 - 5.1e-07 29.9 0.0 0.068 13.5 0.0 4.9 2 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain SNO PF01174.19 KOG97434.1 - 7.3e-90 299.9 0.0 8.2e-90 299.7 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 KOG97434.1 - 8.2e-10 38.6 0.0 1.4e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_S51 PF03575.17 KOG97434.1 - 0.0071 16.0 0.0 0.01 15.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.24 KOG97434.1 - 0.0073 16.1 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 KOG97434.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 ThiJ/PfpI family-like SOR_SNZ PF01680.17 KOG97435.1 - 3.2e-106 353.7 5.5 4.2e-106 353.3 5.5 1.1 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 KOG97435.1 - 2.6e-08 33.5 3.6 2.4e-07 30.3 0.1 2.4 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG Dus PF01207.17 KOG97435.1 - 0.00035 19.8 0.7 0.35 9.9 0.0 2.8 2 1 1 3 3 3 2 Dihydrouridine synthase (Dus) NanE PF04131.14 KOG97435.1 - 0.0031 16.7 1.3 0.086 12.0 0.0 2.6 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase TMP-TENI PF02581.17 KOG97435.1 - 0.0089 15.4 0.5 0.4 10.0 0.1 2.6 2 1 0 2 2 2 1 Thiamine monophosphate synthase His_biosynth PF00977.21 KOG97435.1 - 0.0096 15.4 0.2 0.057 12.9 0.0 2.2 2 0 0 2 2 2 1 Histidine biosynthesis protein NMO PF03060.15 KOG97435.1 - 0.015 14.7 3.7 0.18 11.2 0.2 2.3 2 0 0 2 2 2 0 Nitronate monooxygenase TetR_C_27 PF17935.1 KOG97435.1 - 0.017 15.2 0.0 0.11 12.6 0.0 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain 1-cysPrx_C PF10417.9 KOG97435.1 - 0.054 13.3 0.5 2.2 8.2 0.0 2.6 2 0 0 2 2 2 0 C-terminal domain of 1-Cys peroxiredoxin IGPS PF00218.21 KOG97435.1 - 0.081 12.1 0.1 1.6 7.8 0.0 2.3 2 1 0 2 2 2 0 Indole-3-glycerol phosphate synthase MMR_HSR1 PF01926.23 KOG97436.1 - 3.7e-14 52.8 0.1 8.6e-14 51.6 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG97436.1 - 0.00012 22.0 0.9 0.002 18.1 0.9 2.2 1 1 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 KOG97436.1 - 0.00058 20.4 0.9 0.049 14.2 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 KOG97436.1 - 0.0019 17.9 0.0 0.0038 16.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain GTP_EFTU PF00009.27 KOG97436.1 - 0.003 17.1 0.1 0.0056 16.2 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KOG97436.1 - 0.008 15.7 0.0 0.14 11.7 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOG97436.1 - 0.011 15.8 0.0 2.1 8.4 0.0 2.5 1 1 0 2 2 2 0 Dynamin family NTPase_1 PF03266.15 KOG97436.1 - 0.019 14.9 0.1 0.045 13.7 0.1 1.7 1 0 0 1 1 1 0 NTPase AAA_23 PF13476.6 KOG97436.1 - 0.02 15.4 0.0 0.038 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 KOG97436.1 - 0.021 13.8 0.3 0.33 9.9 0.0 2.1 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Septin PF00735.18 KOG97436.1 - 0.052 12.8 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_25 PF13481.6 KOG97436.1 - 0.069 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 KOG97436.1 - 0.086 12.3 0.0 0.2 11.1 0.0 1.7 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ATP_bind_1 PF03029.17 KOG97436.1 - 0.12 12.2 0.0 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein mRNA_stabil PF13929.6 KOG97437.1 - 5.1e-97 324.3 11.2 8.3e-97 323.6 11.2 1.3 1 0 0 1 1 1 1 mRNA stabilisation RsfS PF02410.15 KOG97437.1 - 1.7e-18 66.8 0.0 4.7e-18 65.4 0.0 1.8 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation Aldose_epim PF01263.20 KOG97438.1 - 1.1e-53 182.5 0.2 1.3e-53 182.3 0.2 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase zf-MYND PF01753.18 KOG97439.1 - 1.4e-08 34.7 15.0 1.4e-08 34.7 15.0 2.0 2 0 0 2 2 2 1 MYND finger Prenyltransf PF01255.19 KOG97440.1 - 5.4e-66 222.3 0.0 7.7e-66 221.8 0.0 1.2 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase SHP PF03579.13 KOG97440.1 - 0.099 12.6 0.4 0.35 10.9 0.4 1.9 1 0 0 1 1 1 0 Small hydrophobic protein WD40 PF00400.32 KOG97441.1 - 3.2e-16 59.4 13.4 0.00047 20.9 0.4 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97441.1 - 1.8e-05 24.9 0.0 2.6 8.4 0.0 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOG97441.1 - 0.024 13.6 0.0 0.14 11.1 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF3283 PF11686.8 KOG97441.1 - 0.42 10.5 2.8 0.5 10.3 1.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3283) Pkinase PF00069.25 KOG97442.1 - 1.6e-65 221.1 0.0 3.6e-65 219.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97442.1 - 4.6e-29 101.5 0.0 6.8e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 KOG97442.1 - 8.6e-11 42.4 1.1 1.5e-10 41.6 0.2 2.0 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 KOG97442.1 - 1e-05 24.7 0.0 2.3e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 KOG97442.1 - 0.0076 15.9 0.1 4 7.0 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 KOG97442.1 - 0.027 13.8 0.0 0.054 12.8 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 KOG97442.1 - 0.061 12.7 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOG97442.1 - 0.12 12.2 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family PGM_PMM_I PF02878.16 KOG97443.1 - 8.5e-37 125.9 0.1 1.5e-36 125.1 0.1 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 KOG97443.1 - 4e-27 94.7 0.0 6.9e-27 93.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 KOG97443.1 - 1.3e-13 51.4 0.0 2.9e-13 50.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 KOG97443.1 - 3.1e-05 24.1 0.0 7.2e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Ku_N PF03731.15 KOG97444.1 - 6.8e-41 140.4 3.7 1.1e-40 139.7 3.7 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.16 KOG97444.1 - 1.3e-32 113.2 0.1 2.2e-32 112.4 0.1 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.14 KOG97444.1 - 0.067 13.9 2.7 0.11 13.2 0.1 2.8 2 1 0 3 3 3 0 Ku70/Ku80 C-terminal arm SPG4 PF17325.2 KOG97445.1 - 2e-39 135.0 0.4 2.3e-39 134.9 0.4 1.0 1 0 0 1 1 1 1 Stationary phase protein 4 MTHFR PF02219.17 KOG97445.1 - 0.15 11.4 0.0 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 Methylenetetrahydrofolate reductase TPP_enzyme_N PF02776.18 KOG97446.1 - 1.9e-58 196.8 0.1 2.3e-57 193.4 0.1 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 KOG97446.1 - 1.7e-51 174.1 0.0 2.4e-50 170.3 0.0 2.5 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 KOG97446.1 - 7.9e-39 132.5 0.3 1.7e-38 131.5 0.3 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Indigoidine_A PF04227.12 KOG97446.1 - 0.045 13.1 0.0 0.71 9.2 0.0 2.6 2 1 1 3 3 3 0 Indigoidine synthase A like protein POR_N PF01855.19 KOG97446.1 - 0.088 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Glyco_tran_WecB PF03808.13 KOG97446.1 - 0.1 12.5 0.0 0.35 10.8 0.0 1.9 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family Myosin_head PF00063.21 KOG97447.1 - 1.6e-232 773.5 11.6 2e-232 773.2 11.6 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 KOG97447.1 - 6.7e-48 162.8 0.2 1.6e-47 161.7 0.2 1.7 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 KOG97447.1 - 5e-13 48.4 0.0 1.2e-12 47.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOG97447.1 - 2.5e-08 33.6 0.0 5.8e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOG97447.1 - 3.3e-07 29.9 0.0 8.2e-07 28.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain AAA_16 PF13191.6 KOG97447.1 - 0.017 15.5 0.0 0.053 13.9 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Hpr_kinase_C PF07475.12 KOG97447.1 - 0.018 14.6 0.0 8.5 5.9 0.0 2.6 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_22 PF13401.6 KOG97447.1 - 0.029 14.7 0.0 0.11 12.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOG97447.1 - 0.062 13.2 0.1 0.16 11.9 0.0 1.7 2 0 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 KOG97447.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain IQ PF00612.27 KOG97447.1 - 0.93 9.5 14.7 2.2 8.3 6.2 2.7 1 1 1 2 2 2 0 IQ calmodulin-binding motif Aldedh PF00171.22 KOG97448.1 - 7.3e-79 265.4 0.0 8.7e-79 265.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family GCR1_C PF12550.8 KOG97449.1 - 5.3e-24 84.3 0.2 1.4e-23 83.0 0.2 1.8 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Med11 PF10280.9 KOG97450.1 - 7e-13 49.2 1.0 9.2e-13 48.8 1.0 1.3 1 0 0 1 1 1 1 Mediator complex protein Med29 PF11568.8 KOG97450.1 - 0.0033 17.6 0.3 0.0042 17.3 0.3 1.2 1 0 0 1 1 1 1 Mediator complex subunit 29 UPF0242 PF06785.11 KOG97450.1 - 0.03 14.4 1.8 0.032 14.3 1.2 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus zf-CCCH_6 PF18585.1 KOG97450.1 - 0.048 13.5 0.0 0.33 10.9 0.0 2.1 1 1 1 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 L31 PF09784.9 KOG97450.1 - 0.079 13.4 0.0 0.12 12.9 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L31 DUF4015 PF13200.6 KOG97450.1 - 0.12 11.3 0.0 0.18 10.8 0.0 1.3 1 1 0 1 1 1 0 Putative glycosyl hydrolase domain Fzo_mitofusin PF04799.13 KOG97450.1 - 0.91 9.1 4.0 7.5 6.1 4.0 2.0 1 1 0 1 1 1 0 fzo-like conserved region Mur_ligase_M PF08245.12 KOG97451.1 - 1.4e-05 25.2 0.0 4.8e-05 23.4 0.0 1.9 1 1 0 1 1 1 1 Mur ligase middle domain SRAP PF02586.14 KOG97452.1 - 2.3e-64 217.0 0.6 3.2e-64 216.5 0.6 1.2 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) Sigma_reg_C PF13791.6 KOG97452.1 - 0.93 9.7 8.8 3.6 7.8 0.0 3.1 3 1 1 4 4 4 0 Sigma factor regulator C-terminal WD40 PF00400.32 KOG97453.1 - 5.1e-44 147.4 11.0 3.2e-07 30.9 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97453.1 - 9.7e-11 41.8 1.1 0.0083 16.4 0.0 4.8 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOG97453.1 - 1.8e-07 30.5 1.2 0.011 14.7 0.0 4.0 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KOG97453.1 - 8.3e-07 28.0 4.3 0.013 14.2 0.1 4.4 2 1 1 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.11 KOG97453.1 - 3.4e-05 23.8 0.5 0.0062 16.4 0.0 3.1 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KOG97453.1 - 0.0013 18.1 0.1 0.0032 16.8 0.1 1.6 1 1 0 1 1 1 1 WD40-like domain Nbas_N PF15492.6 KOG97453.1 - 0.048 13.0 0.5 1.1 8.6 0.0 2.9 3 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 KOG97453.1 - 0.094 12.7 0.1 20 5.3 0.0 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 KOG97453.1 - 0.1 11.3 0.4 5.5 5.6 0.2 3.1 1 1 2 3 3 3 0 Nup133 N terminal like KOW PF00467.29 KOG97453.1 - 0.18 11.8 0.0 0.59 10.2 0.0 1.9 1 0 0 1 1 1 0 KOW motif Spc24 PF08286.11 KOG97454.1 - 1.4e-23 83.1 2.9 1.4e-23 83.1 2.9 2.2 2 1 1 3 3 3 1 Spc24 subunit of Ndc80 HIP1_clath_bdg PF16515.5 KOG97454.1 - 0.014 16.0 1.2 0.032 14.8 0.1 2.0 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Sdh_cyt PF01127.22 KOG97455.1 - 6.3e-26 90.8 1.6 8.5e-26 90.4 1.6 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit zf-C3HC4_3 PF13920.6 KOG97456.1 - 8.4e-08 32.0 10.8 8.4e-08 32.0 10.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOG97456.1 - 9.2 6.2 14.0 22 5.0 14.0 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 AICARFT_IMPCHas PF01808.18 KOG97457.1 - 3.4e-93 312.4 0.0 5.5e-93 311.7 0.0 1.3 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 KOG97457.1 - 9.9e-25 86.6 0.4 2.3e-24 85.4 0.0 1.8 2 0 0 2 2 2 1 MGS-like domain Dis3l2_C_term PF17877.1 KOG97457.1 - 0.043 14.2 0.0 0.13 12.6 0.0 1.8 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal Ribosomal_L15e PF00827.17 KOG97458.1 - 6.5e-90 300.0 13.0 8.1e-90 299.7 13.0 1.0 1 0 0 1 1 1 1 Ribosomal L15 Pkr1 PF08636.10 KOG97460.1 - 3.5e-29 100.7 11.5 4.5e-29 100.4 11.5 1.1 1 0 0 1 1 1 1 ER protein Pkr1 YbjQ_1 PF01906.17 KOG97461.1 - 0.19 12.4 0.1 0.47 11.1 0.1 1.6 1 0 0 1 1 1 0 Putative heavy-metal-binding MIF4G_like PF09088.11 KOG97462.1 - 1.4e-52 178.3 0.5 3.1e-52 177.2 0.5 1.6 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 KOG97462.1 - 1.1e-51 175.9 6.8 9.1e-51 172.9 2.9 3.1 2 1 0 2 2 2 1 MIF4G like MIF4G PF02854.19 KOG97462.1 - 5e-18 65.5 7.8 5e-18 65.5 7.8 4.0 4 2 1 5 5 5 1 MIF4G domain YmgB PF10798.8 KOG97462.1 - 0.27 11.1 4.2 4.9 7.0 0.0 3.5 3 0 0 3 3 3 0 Biofilm development protein YmgB/AriR EF-hand_7 PF13499.6 KOG97462.1 - 0.34 11.4 2.5 1.6 9.2 0.0 3.0 3 0 0 3 3 3 0 EF-hand domain pair DUF4535 PF15054.6 KOG97462.1 - 0.37 10.6 1.5 0.73 9.6 0.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4535) MOZ_SAS PF01853.18 KOG97464.1 - 7.8e-59 198.3 0.5 1.2e-58 197.7 0.5 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 KOG97464.1 - 8.5e-08 31.7 3.6 1.8e-06 27.4 3.6 2.5 1 1 0 1 1 1 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 KOG97464.1 - 8.3e-05 22.9 0.0 0.00018 21.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOG97464.1 - 0.02 15.1 0.0 0.055 13.7 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) family HA2 PF04408.23 KOG97465.1 - 5e-27 94.3 2.4 2.7e-26 91.9 0.0 3.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KOG97465.1 - 4e-14 52.7 0.0 1.2e-13 51.3 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KOG97465.1 - 7.9e-14 51.9 1.0 2.3e-11 44.0 0.0 3.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOG97465.1 - 2.8e-07 30.5 0.1 9.5e-07 28.7 0.1 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOG97465.1 - 0.00011 22.5 0.5 0.00043 20.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOG97465.1 - 0.003 17.3 0.0 0.0065 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOG97465.1 - 0.0031 17.8 0.0 0.0098 16.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 KOG97465.1 - 0.012 15.0 0.5 0.012 15.0 0.5 2.6 2 1 1 3 3 3 0 KaiC T2SSE PF00437.20 KOG97465.1 - 0.015 14.4 0.0 0.032 13.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein HTH_37 PF13744.6 KOG97465.1 - 0.031 14.2 0.4 0.031 14.2 0.4 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain PhoH PF02562.16 KOG97465.1 - 0.041 13.3 0.0 0.12 11.9 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein Hydrolase PF00702.26 KOG97467.1 - 4.2e-10 40.3 0.0 7.2e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOG97467.1 - 4.5e-07 29.8 0.0 8.7e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 KOG97467.1 - 0.00011 22.4 0.6 0.0002 21.5 0.0 1.9 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase CAF1C_H4-bd PF12265.8 KOG97468.1 - 8.8e-16 57.9 0.1 2.6e-15 56.4 0.1 1.9 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 KOG97468.1 - 2e-10 41.1 6.5 0.0015 19.3 0.0 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97468.1 - 4.8e-07 30.0 1.8 0.013 15.8 0.4 3.3 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain NFACT-R_1 PF05670.13 KOG97469.1 - 1.1e-33 116.2 0.0 1.8e-33 115.4 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain DUF3551 PF12071.8 KOG97469.1 - 0.14 12.2 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3551) CLTH PF10607.9 KOG97471.1 - 1.9e-21 76.5 7.4 1.9e-21 76.5 7.4 2.2 1 1 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-CCHH PF10283.9 KOG97471.1 - 0.099 12.6 0.6 0.24 11.4 0.6 1.7 1 0 0 1 1 1 0 PBZ domain GATA PF00320.27 KOG97472.1 - 2.4e-16 59.0 3.8 4.7e-16 58.1 3.8 1.5 1 0 0 1 1 1 1 GATA zinc finger Nudix_N_2 PF14803.6 KOG97472.1 - 0.23 11.4 1.8 0.49 10.4 1.8 1.5 1 0 0 1 1 1 0 Nudix N-terminal DUF4407 PF14362.6 KOG97472.1 - 0.58 9.5 9.4 0.95 8.8 9.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4175 PF13779.6 KOG97472.1 - 1.8 6.4 15.5 2.7 5.8 15.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Roughex PF06020.11 KOG97472.1 - 4.6 6.3 11.6 8.3 5.4 11.6 1.4 1 0 0 1 1 1 0 Drosophila roughex protein WBP-1 PF11669.8 KOG97472.1 - 4.9 7.8 9.0 1.7 9.3 5.5 2.2 2 0 0 2 2 2 0 WW domain-binding protein 1 DUF702 PF05142.12 KOG97472.1 - 9.7 6.7 12.2 12 6.4 7.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF702) DRMBL PF07522.14 KOG97473.1 - 3.8e-25 88.2 0.3 8.4e-25 87.1 0.0 1.7 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Nitrophorin PF02087.15 KOG97473.1 - 0.014 15.4 0.0 0.039 13.9 0.0 1.7 1 0 0 1 1 1 0 Nitrophorin Lactamase_B PF00753.27 KOG97473.1 - 0.07 13.1 0.0 0.19 11.7 0.0 1.7 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KOG97473.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Arf PF00025.21 KOG97474.1 - 3.4e-51 173.1 0.1 4.2e-51 172.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 KOG97474.1 - 3e-13 49.7 1.5 3.6e-08 32.9 0.2 2.6 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 KOG97474.1 - 4.1e-11 43.1 0.0 5.5e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KOG97474.1 - 4.6e-10 39.2 0.0 5.7e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 KOG97474.1 - 1.3e-09 37.9 0.0 1.5e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 KOG97474.1 - 3e-07 30.5 0.0 4.6e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG97474.1 - 9.7e-06 25.6 0.1 0.017 15.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 KOG97474.1 - 2e-05 24.1 0.0 2.5e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 KOG97474.1 - 9.3e-05 22.0 0.1 0.00021 20.8 0.1 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 KOG97474.1 - 0.0007 19.2 0.0 0.12 11.9 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain cobW PF02492.19 KOG97474.1 - 0.012 15.2 0.1 0.86 9.2 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 KOG97474.1 - 0.022 13.7 0.0 0.29 10.1 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_29 PF13555.6 KOG97474.1 - 0.078 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 KOG97474.1 - 0.14 11.6 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Pkinase PF00069.25 KOG97475.1 - 1.5e-64 217.9 0.0 1.8e-64 217.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97475.1 - 1.5e-26 93.3 0.0 2e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOG97475.1 - 0.0032 17.4 0.1 0.039 13.9 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 KOG97475.1 - 0.0096 15.5 0.4 0.018 14.6 0.2 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase WHIM1 PF15612.6 KOG97475.1 - 0.028 14.0 0.0 0.07 12.7 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 FAS_meander PF17951.1 KOG97475.1 - 0.052 13.4 1.9 0.061 13.1 0.7 1.7 2 0 0 2 2 2 0 Fatty acid synthase meander beta sheet domain RICTOR_M PF14666.6 KOG97475.1 - 0.17 11.7 1.3 0.36 10.6 1.3 1.6 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, middle domain zf-C3HC4_3 PF13920.6 KOG97476.1 - 0.2 11.5 6.1 0.45 10.4 3.0 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) CtsR_C PF17727.1 KOG97477.1 - 0.095 12.8 3.0 0.15 12.2 0.1 2.6 2 1 1 3 3 3 0 CtsR C-terminal dimerization domain Hydrolase_6 PF13344.6 KOG97477.1 - 0.68 10.1 3.4 0.93 9.6 1.6 2.1 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase ZapB PF06005.12 KOG97477.1 - 4 8.0 16.4 39 4.8 16.4 2.5 1 1 0 1 1 1 0 Cell division protein ZapB Pyr_redox_2 PF07992.14 KOG97478.1 - 8.4e-51 172.9 0.0 1.1e-50 172.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOG97478.1 - 2.6e-12 47.1 0.0 1.8e-11 44.5 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOG97478.1 - 0.0017 17.7 0.1 2.9 7.0 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DUF4928 PF16280.5 KOG97478.1 - 0.021 14.1 0.1 0.23 10.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4928) Pox_F15 PF04596.12 KOG97478.1 - 0.14 11.9 0.1 0.4 10.4 0.0 1.7 2 0 0 2 2 2 0 Poxvirus protein F15 NAD_binding_9 PF13454.6 KOG97478.1 - 0.19 11.7 0.5 17 5.3 0.0 3.3 3 1 1 4 4 4 0 FAD-NAD(P)-binding WD40 PF00400.32 KOG97479.1 - 2.1e-25 88.5 6.5 5.3e-06 27.1 0.6 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97479.1 - 5.4e-09 36.2 0.0 0.035 14.4 0.0 5.1 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOG97479.1 - 3.1e-06 27.2 0.1 0.11 12.3 0.0 3.4 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KOG97479.1 - 0.024 13.3 0.4 1.7 7.2 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 ESR1_C PF12743.7 KOG97480.1 - 0.037 13.8 0.8 0.082 12.7 0.8 1.5 1 0 0 1 1 1 0 Oestrogen-type nuclear receptor final C-terminal Osw5 PF17062.5 KOG97481.1 - 5.8e-29 100.0 15.1 7.8e-29 99.6 15.1 1.2 1 0 0 1 1 1 1 Outer spore wall 5 Ribophorin_II PF05817.14 KOG97482.1 - 2.2e-11 43.1 2.7 2.8e-11 42.7 2.7 1.2 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II DUF2140 PF09911.9 KOG97482.1 - 0.056 13.0 0.2 0.14 11.7 0.2 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) 2HCT PF03390.15 KOG97482.1 - 0.073 11.7 3.8 0.13 10.9 3.8 1.3 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family DUF1516 PF07457.11 KOG97482.1 - 0.088 13.0 3.0 0.23 11.7 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1516) CBP_BcsF PF11120.8 KOG97482.1 - 0.52 10.5 4.0 1.8 8.7 0.2 2.4 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF Peptidase_S24 PF00717.23 KOG97483.1 - 9.1e-07 28.7 0.0 2.5e-06 27.3 0.0 1.8 1 1 1 2 2 2 2 Peptidase S24-like Peptidase_S26 PF10502.9 KOG97483.1 - 0.0015 18.3 0.0 0.012 15.4 0.0 2.1 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 ADH_zinc_N_2 PF13602.6 KOG97484.1 - 1e-13 52.5 0.0 1.8e-13 51.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KOG97484.1 - 1.9e-05 24.6 0.0 3.8e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOG97484.1 - 0.00027 20.8 0.0 0.00056 19.8 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Nup35_RRM PF05172.13 KOG97485.1 - 1.1e-35 121.7 0.0 2.1e-35 120.7 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 KOG97485.1 - 0.001 19.0 0.0 0.0022 18.0 0.0 1.6 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif TFIIA PF03153.13 KOG97485.1 - 0.004 17.2 21.0 0.004 17.2 21.0 1.7 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 KOG97485.1 - 1.4 8.5 31.9 4.5 6.8 31.9 1.8 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 KOG97485.1 - 7 5.4 22.9 9.7 4.9 22.9 1.2 1 0 0 1 1 1 0 Androgen receptor Calpain_III PF01067.22 KOG97486.1 - 0.016 15.5 0.7 0.31 11.3 0.7 2.8 1 1 0 1 1 1 0 Calpain large subunit, domain III MFS_1 PF07690.16 KOG97487.1 - 1.9e-13 50.1 12.6 3e-13 49.5 11.8 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.13 KOG97487.1 - 4.2e-10 39.5 5.6 4.2e-10 39.5 5.6 1.8 2 0 0 2 2 2 1 Nodulin-like PNK3P PF08645.11 KOG97488.1 - 3.4e-45 153.6 0.8 4e-45 153.4 0.8 1.0 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase DUF1463 PF07316.11 KOG97488.1 - 0.01 15.7 0.1 0.016 15.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1463) DUF3024 PF11225.8 KOG97488.1 - 0.049 13.9 0.1 0.25 11.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3024) PRR18 PF15671.5 KOG97489.1 - 0.037 13.9 0.2 0.088 12.7 0.1 1.6 2 0 0 2 2 2 0 Proline-rich protein family 18 Ribosomal_S8 PF00410.19 KOG97490.1 - 2e-13 50.4 0.0 1.1e-12 48.0 0.0 1.8 1 1 0 1 1 1 1 Ribosomal protein S8 NrsF PF06532.11 KOG97491.1 - 0.19 11.4 1.3 0.35 10.5 1.3 1.3 1 0 0 1 1 1 0 Negative regulator of sigma F EPL1 PF10513.9 KOG97491.1 - 0.58 10.5 14.3 8.2 6.8 7.8 3.0 2 1 0 2 2 2 0 Enhancer of polycomb-like DnaJ PF00226.31 KOG97492.1 - 3.4e-25 88.0 1.3 6.5e-25 87.0 1.3 1.5 1 0 0 1 1 1 1 DnaJ domain PhoLip_ATPase_C PF16212.5 KOG97493.1 - 1.5e-67 227.9 24.5 1.5e-67 227.9 24.5 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KOG97493.1 - 8.8e-22 76.6 1.4 8.8e-22 76.6 1.4 2.9 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KOG97493.1 - 1.5e-12 48.2 0.4 2.6e-06 27.9 0.0 3.9 3 1 1 4 4 4 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KOG97493.1 - 2.7e-11 43.3 0.0 9.4e-11 41.6 0.0 1.8 1 1 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 KOG97493.1 - 1.2e-10 41.3 0.0 8e-10 38.7 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KOG97493.1 - 0.007 16.1 0.2 0.007 16.1 0.2 3.0 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOG97493.1 - 1.4 9.0 4.8 3.9 7.5 0.1 2.9 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase LEM PF03020.15 KOG97494.1 - 2.8 7.6 7.4 0.25 10.9 0.4 2.8 4 0 0 4 4 4 0 LEM domain LNS2 PF08235.13 KOG97495.1 - 7.7e-95 316.7 0.0 1.1e-94 316.1 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 KOG97495.1 - 4e-42 142.3 0.0 2.1e-41 140.0 0.0 2.2 3 0 0 3 3 3 1 lipin, N-terminal conserved region Mito_carr PF00153.27 KOG97496.1 - 3.8e-68 225.5 1.1 1.3e-24 85.9 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Mlh1_C PF16413.5 KOG97497.1 - 4.5e-86 288.6 0.0 7.4e-86 287.9 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 KOG97497.1 - 4.6e-29 100.5 1.7 4.7e-29 100.5 0.2 1.8 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 KOG97497.1 - 6.9e-12 45.4 0.1 1.6e-11 44.2 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KOG97497.1 - 2.5e-06 28.0 0.0 5.7e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cep3 PF16846.5 KOG97498.1 - 5.5e-215 714.7 13.8 6.3e-215 714.5 13.8 1.0 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit B Zn_clus PF00172.18 KOG97498.1 - 2e-07 31.0 11.4 2e-07 31.0 11.4 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldedh PF00171.22 KOG97499.1 - 3.9e-169 563.0 0.0 4.4e-169 562.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.22 KOG97500.1 - 1.2e-168 561.4 0.0 1.4e-168 561.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 KOG97500.1 - 0.13 11.3 0.0 0.29 10.1 0.0 1.5 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) Prominin PF05478.11 KOG97500.1 - 0.27 9.1 0.0 0.38 8.6 0.0 1.1 1 0 0 1 1 1 0 Prominin SPRY PF00622.28 KOG97501.1 - 7e-11 42.3 0.1 1.2e-10 41.5 0.1 1.4 1 0 0 1 1 1 1 SPRY domain GCR1_C PF12550.8 KOG97502.1 - 9.8e-22 77.1 2.2 1.9e-21 76.2 2.2 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes YL1 PF05764.13 KOG97502.1 - 0.2 11.8 11.0 0.54 10.3 11.0 1.8 1 0 0 1 1 1 0 YL1 nuclear protein KCT2 PF17818.1 KOG97502.1 - 3.1 7.9 9.1 1.3 9.1 3.1 2.6 2 0 0 2 2 2 0 Keratinocyte-associated gene product Inhibitor_I34 PF10466.9 KOG97504.1 - 5.7e-33 113.3 9.5 6.2e-33 113.2 9.5 1.0 1 0 0 1 1 1 1 Saccharopepsin inhibitor I34 ARID PF01388.21 KOG97505.1 - 1.8e-17 63.8 0.5 1.6e-16 60.8 0.0 3.0 3 0 0 3 3 3 1 ARID/BRIGHT DNA binding domain JmjC PF02373.22 KOG97505.1 - 6.2e-10 39.5 0.2 1.2e-05 25.7 0.1 2.7 2 0 0 2 2 2 2 JmjC domain, hydroxylase PHD PF00628.29 KOG97505.1 - 2.1e-07 30.7 6.1 4.2e-07 29.7 6.1 1.5 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 KOG97505.1 - 0.044 13.9 7.7 0.1 12.7 7.7 1.6 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 KOG97505.1 - 0.046 13.8 1.3 0.18 11.9 1.3 2.1 1 0 0 1 1 1 0 KIAA1045 RING finger zf-HC5HC2H PF13771.6 KOG97505.1 - 0.059 13.6 2.5 0.15 12.4 2.5 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain C1_1 PF00130.22 KOG97505.1 - 0.25 11.3 5.0 0.58 10.1 5.0 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.6 KOG97505.1 - 3.7 7.9 8.0 13 6.2 8.0 2.1 1 0 0 1 1 1 0 Ring finger domain Cation_efflux PF01545.21 KOG97506.1 - 4.1e-41 140.9 12.6 6.1e-41 140.4 12.6 1.3 1 0 0 1 1 1 1 Cation efflux family MoCF_biosynth PF00994.24 KOG97507.1 - 3.7e-35 120.7 0.0 7.9e-35 119.6 0.0 1.5 2 0 0 2 2 2 1 Probable molybdopterin binding domain mRNA_triPase PF02940.15 KOG97509.1 - 1.8e-44 152.1 3.3 1.8e-44 152.1 3.3 1.4 2 0 0 2 2 2 1 mRNA capping enzyme, beta chain RNase_Zc3h12a PF11977.8 KOG97510.1 - 0.098 12.4 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain zf-C2H2 PF00096.26 KOG97511.1 - 2.2e-11 43.5 8.4 5.3e-06 26.6 1.3 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOG97511.1 - 2.9e-09 36.9 2.0 2.9e-09 36.9 2.0 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOG97511.1 - 9.9e-06 26.0 6.5 0.012 16.4 0.8 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOG97511.1 - 0.00039 20.3 0.1 0.00039 20.3 0.1 1.8 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 KOG97511.1 - 0.00063 20.0 4.6 0.13 12.7 1.0 2.4 2 0 0 2 2 2 2 Zinc-finger of C2H2 type Homoserine_dh PF00742.19 KOG97511.1 - 0.002 18.1 0.0 0.0028 17.6 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase zf_C2H2_ZHX PF18387.1 KOG97511.1 - 0.05 13.3 1.4 1.1 9.0 0.8 2.2 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_3rep PF18868.1 KOG97511.1 - 0.064 13.9 1.9 0.26 12.0 0.2 2.0 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 KOG97511.1 - 0.23 11.8 4.2 4.3 7.8 0.7 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-MYST PF17772.1 KOG97511.1 - 0.33 10.6 0.1 0.33 10.6 0.1 2.0 2 1 0 2 2 2 0 MYST family zinc finger domain zf-H2C2_5 PF13909.6 KOG97511.1 - 0.49 10.2 4.6 2.8 7.8 1.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2HE PF16278.5 KOG97511.1 - 0.66 10.5 3.6 2.1 8.8 3.6 1.9 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger Syntaxin PF00804.25 KOG97512.1 - 5.8e-21 75.1 18.8 5.8e-21 75.1 18.8 2.4 1 1 1 2 2 2 1 Syntaxin SNARE PF05739.19 KOG97512.1 - 9.6e-16 57.5 1.5 9.6e-16 57.5 1.5 2.2 2 0 0 2 2 2 1 SNARE domain Synaptobrevin PF00957.21 KOG97512.1 - 0.00018 21.2 1.6 0.00018 21.2 1.6 1.9 2 0 0 2 2 2 1 Synaptobrevin SLATT_5 PF18160.1 KOG97512.1 - 0.011 15.1 1.1 0.026 13.8 0.0 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF948 PF06103.11 KOG97512.1 - 0.016 15.5 4.0 0.016 15.5 4.0 3.4 4 1 0 4 4 3 0 Bacterial protein of unknown function (DUF948) Orthopox_B11R PF07033.11 KOG97512.1 - 0.06 13.2 2.4 5.3 6.9 0.1 2.7 2 0 0 2 2 2 0 Orthopoxvirus B11R protein DUF2207 PF09972.9 KOG97512.1 - 0.06 12.1 0.0 0.06 12.1 0.0 2.0 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) T2SSF PF00482.23 KOG97512.1 - 0.1 12.5 2.8 0.087 12.8 0.5 2.0 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F LMBR1 PF04791.16 KOG97512.1 - 0.12 11.3 6.5 0.17 10.7 6.5 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF745 PF05335.13 KOG97512.1 - 1.1 9.0 18.0 0.11 12.2 11.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF745) DUF2116 PF09889.9 KOG97512.1 - 2.1 8.4 4.5 0.44 10.6 0.9 1.8 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) PBP1_TM PF14812.6 KOG97512.1 - 4.2 7.8 10.7 0.5 10.8 0.2 2.8 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SlyX PF04102.12 KOG97512.1 - 4.3 8.0 13.3 0.57 10.8 3.6 2.9 2 1 0 2 2 2 0 SlyX RTP1_C1 PF10363.9 KOG97514.1 - 3.1e-33 114.3 0.5 1.8e-32 111.9 0.0 2.6 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 KOG97514.1 - 1.8e-08 33.9 2.2 4.4e-08 32.7 2.2 1.7 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 PMC2NT PF08066.12 KOG97514.1 - 0.51 11.1 8.7 0.15 12.7 1.4 3.5 1 1 2 3 3 3 0 PMC2NT (NUC016) domain HSP90 PF00183.18 KOG97515.1 - 3.1e-219 729.2 34.6 4.3e-219 728.7 34.6 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 KOG97515.1 - 1.3e-13 51.4 0.0 2.5e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KOG97515.1 - 4.4e-09 36.3 0.0 1.3e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ubiq-assoc PF09145.10 KOG97515.1 - 0.07 13.1 0.2 2.6 8.1 0.0 3.0 3 0 0 3 3 3 0 Ubiquitin-associated Peptidase_S10 PF00450.22 KOG97515.1 - 0.11 11.9 0.3 0.73 9.2 0.0 2.1 2 0 0 2 2 2 0 Serine carboxypeptidase Tau95 PF09734.9 KOG97515.1 - 5.2 7.9 7.5 1.5 9.6 3.0 2.4 3 0 0 3 3 3 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain RINGv PF12906.7 KOG97516.1 - 0.0021 18.1 6.5 0.0059 16.7 6.5 1.8 1 0 0 1 1 1 1 RING-variant domain stn_TNFRSF12A PF12191.8 KOG97516.1 - 0.11 12.7 0.0 0.3 11.3 0.0 1.7 1 1 1 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain FANCL_C PF11793.8 KOG97516.1 - 4 7.7 12.0 17 5.7 0.1 2.5 2 0 0 2 2 2 0 FANCL C-terminal domain zf-RING_2 PF13639.6 KOG97516.1 - 7.4 7.0 14.0 3.2 8.2 9.6 2.4 2 0 0 2 2 2 0 Ring finger domain zf-RING_4 PF14570.6 KOG97516.1 - 8.4 6.3 8.3 32 4.4 4.0 2.7 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Ribosomal_S17 PF00366.20 KOG97517.1 - 1.2e-22 79.7 0.2 2e-22 79.1 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 GDC-P PF02347.16 KOG97518.1 - 7.2e-207 687.4 0.0 8.9e-195 647.5 0.0 2.2 2 0 0 2 2 2 2 Glycine cleavage system P-protein Cys_Met_Meta_PP PF01053.20 KOG97518.1 - 0.0009 17.9 0.0 0.0028 16.3 0.0 1.7 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Helicase_Sgs1 PF11408.8 KOG97519.1 - 5.4e-33 112.9 0.1 1.7e-32 111.3 0.1 1.9 1 0 0 1 1 1 1 Sgs1 RecQ helicase RQC PF09382.10 KOG97519.1 - 1.6e-28 98.8 0.1 3.3e-28 97.8 0.1 1.6 1 0 0 1 1 1 1 RQC domain Helicase_C PF00271.31 KOG97519.1 - 5.5e-24 84.6 1.2 3.8e-18 65.9 0.0 3.4 4 0 0 4 4 4 2 Helicase conserved C-terminal domain DEAD PF00270.29 KOG97519.1 - 3e-22 79.2 0.3 2.8e-21 76.1 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 KOG97519.1 - 9.4e-16 58.3 9.1 3.8e-15 56.4 9.1 2.2 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 KOG97519.1 - 8.5e-08 32.4 0.2 3.8e-06 27.0 0.0 3.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HRDC PF00570.23 KOG97519.1 - 0.041 13.9 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 HRDC domain Rhodanese PF00581.20 KOG97519.1 - 0.055 14.0 1.7 14 6.3 0.0 3.6 2 1 1 3 3 3 0 Rhodanese-like domain RabGAP-TBC PF00566.18 KOG97521.1 - 7.6e-25 87.8 3.2 7.6e-25 87.8 3.2 2.9 3 1 1 4 4 4 1 Rab-GTPase-TBC domain CALCOCO1 PF07888.11 KOG97521.1 - 0.048 12.5 11.9 0.095 11.5 11.9 1.4 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Pox_A_type_inc PF04508.12 KOG97521.1 - 0.71 9.8 4.0 7.3 6.6 0.3 3.4 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat IFP_35_N PF07334.13 KOG97521.1 - 1.8 8.7 6.4 0.76 9.9 1.2 2.8 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF4988 PF16378.5 KOG97521.1 - 2.9 7.5 7.6 1.2 8.8 3.5 2.4 2 1 1 3 3 3 0 Domain of unknown function Ribosomal_L28 PF00830.19 KOG97522.1 - 1.7e-18 66.5 1.5 3.9e-18 65.4 1.5 1.6 1 0 0 1 1 1 1 Ribosomal L28 family Ribosomal_L36e PF01158.18 KOG97523.1 - 6e-37 125.8 2.8 6.7e-37 125.6 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Glyco_hydro_63 PF03200.16 KOG97526.1 - 2.4e-06 26.6 10.7 0.00043 19.2 0.2 5.1 4 2 0 4 4 4 2 Glycosyl hydrolase family 63 C-terminal domain CAF1-p150_N PF15557.6 KOG97526.1 - 0.0035 17.3 0.4 0.0059 16.6 0.4 1.2 1 0 0 1 1 1 1 CAF1 complex subunit p150, region binding to PCNA V-SNARE_C PF12352.8 KOG97527.1 - 5.4e-22 77.9 2.1 5.4e-22 77.9 2.1 2.4 2 1 1 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 KOG97527.1 - 1.6e-19 70.1 4.0 1.6e-19 70.1 4.0 2.4 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 KOG97527.1 - 0.00086 19.2 1.4 0.00086 19.2 1.4 2.4 2 1 0 2 2 2 1 Sec20 Snapin_Pallidin PF14712.6 KOG97527.1 - 0.028 14.8 3.1 0.028 14.8 3.1 2.5 2 1 0 2 2 2 0 Snapin/Pallidin ER PF01133.17 KOG97527.1 - 0.069 13.2 0.6 0.21 11.6 0.1 1.9 2 0 0 2 2 2 0 Enhancer of rudimentary Pox_EPC_I2-L1 PF12575.8 KOG97527.1 - 0.11 12.7 1.9 19 5.6 0.0 2.4 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 Nsp1_C PF05064.13 KOG97527.1 - 0.85 9.4 10.2 0.084 12.7 2.5 2.8 2 2 1 3 3 3 0 Nsp1-like C-terminal region Stathmin PF00836.19 KOG97527.1 - 0.92 9.5 5.4 0.15 12.0 1.0 1.8 2 1 0 2 2 2 0 Stathmin family Fusion_gly PF00523.18 KOG97527.1 - 1.2 7.3 6.5 0.49 8.6 0.5 2.4 2 1 1 3 3 3 0 Fusion glycoprotein F0 Spc24 PF08286.11 KOG97527.1 - 1.6 9.0 7.7 0.34 11.2 3.3 1.9 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Endonuc_Holl PF10107.9 KOG97527.1 - 2.9 7.7 6.4 0.52 10.1 2.3 1.8 2 1 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase Microtub_bd PF16796.5 KOG97528.1 - 2.2e-08 34.2 1.1 2.2e-08 34.2 1.1 3.2 2 1 1 3 3 3 1 Microtubule binding Cep57_MT_bd PF06657.13 KOG97528.1 - 0.01 16.3 22.3 0.29 11.6 2.2 4.7 2 1 2 4 4 4 3 Centrosome microtubule-binding domain of Cep57 HTH_57 PF18679.1 KOG97528.1 - 0.21 11.9 4.4 12 6.3 0.4 3.1 1 1 1 2 2 2 0 ThcOx helix turn helix domain PMC2NT PF08066.12 KOG97528.1 - 0.36 11.6 7.1 0.32 11.7 1.3 3.3 2 1 0 2 2 2 0 PMC2NT (NUC016) domain T3SSipB PF16535.5 KOG97528.1 - 0.38 11.2 11.3 0.12 12.8 4.2 2.8 1 1 0 2 2 2 0 Type III cell invasion protein SipB DUF4407 PF14362.6 KOG97528.1 - 1.6 8.0 23.9 0.18 11.2 9.8 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) HrpB7 PF09486.10 KOG97528.1 - 2 8.8 15.7 0.11 12.9 2.2 2.6 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) RsbU_N PF08673.10 KOG97528.1 - 3.5 7.8 6.1 12 6.1 0.1 3.5 4 0 0 4 4 4 0 Phosphoserine phosphatase RsbU, N-terminal domain Lebercilin PF15619.6 KOG97528.1 - 7.5 6.2 42.5 9.6 5.8 14.9 3.9 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Cyclin_N PF00134.23 KOG97529.1 - 2.3e-39 134.0 0.0 4.3e-39 133.2 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Rot1 PF10681.9 KOG97530.1 - 3.4e-97 324.0 0.1 3.9e-97 323.8 0.1 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal XPA_C PF05181.12 KOG97531.1 - 4.3e-22 77.8 0.1 9e-22 76.8 0.1 1.6 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 KOG97531.1 - 0.032 14.3 0.8 0.032 14.3 0.8 2.0 2 0 0 2 2 2 0 XPA protein N-terminal Cytochrome_C554 PF13435.6 KOG97531.1 - 4.6 8.2 8.9 2.6 9.0 1.4 3.1 2 1 1 3 3 3 0 Cytochrome c554 and c-prime ERG2_Sigma1R PF04622.12 KOG97532.1 - 6.8e-93 309.8 1.6 8.1e-93 309.5 1.6 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Porin_3 PF01459.22 KOG97533.1 - 7.7e-87 291.2 0.2 9.1e-87 290.9 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin Inp1 PF12634.7 KOG97534.1 - 1.3e-40 138.6 0.2 1.3e-40 138.6 0.2 1.9 2 0 0 2 2 2 1 Inheritance of peroxisomes protein 1 PFK PF00365.20 KOG97535.1 - 6.7e-182 603.1 0.3 8.4e-101 337.0 0.7 2.1 2 0 0 2 2 2 2 Phosphofructokinase DUF4667 PF15700.5 KOG97536.1 - 5.5e-62 210.0 27.0 8.5e-62 209.4 27.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4667) Carboxyl_trans PF01039.22 KOG97537.1 - 3.8e-180 599.7 0.0 5e-180 599.4 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain ACC_central PF08326.12 KOG97537.1 - 6.5e-158 527.2 6.7 9.2e-158 526.7 6.7 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.17 KOG97537.1 - 6e-52 176.2 0.0 1.1e-51 175.4 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 KOG97537.1 - 2.1e-22 79.3 0.0 8.4e-22 77.3 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 KOG97537.1 - 2e-19 70.1 0.0 3.8e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 KOG97537.1 - 2.4e-17 62.5 0.2 6.5e-17 61.1 0.2 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 KOG97537.1 - 0.00052 20.1 0.0 0.0012 18.9 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 KOG97537.1 - 0.001 18.9 0.0 0.043 13.7 0.0 2.4 2 0 0 2 2 2 1 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 KOG97537.1 - 0.038 13.5 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KOG97537.1 - 0.064 12.8 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain ATPgrasp_Ter PF15632.6 KOG97537.1 - 0.093 12.5 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon GHMP_kinases_N PF00288.26 KOG97538.1 - 1.6e-20 73.1 0.7 4.1e-20 71.8 0.7 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KOG97538.1 - 4.8e-05 23.6 0.1 0.0005 20.4 0.1 2.6 1 1 1 2 2 2 1 GHMP kinases C terminal N2227 PF07942.12 KOG97539.1 - 1.5e-70 237.5 0.2 2.6e-70 236.7 0.0 1.4 2 0 0 2 2 2 1 N2227-like protein Abhydrolase_1 PF00561.20 KOG97540.1 - 1.8e-15 57.3 0.0 4.6e-15 56.0 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOG97540.1 - 1.8e-06 27.4 0.0 3e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF915 PF06028.11 KOG97540.1 - 0.0052 16.1 0.0 0.012 14.9 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Cutinase PF01083.22 KOG97540.1 - 0.019 14.9 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 Cutinase VirJ PF06057.11 KOG97540.1 - 0.22 11.4 0.0 0.38 10.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Tubulin_3 PF14881.6 KOG97541.1 - 1.6e-22 80.0 0.2 4e-22 78.8 0.0 1.7 2 0 0 2 2 2 1 Tubulin domain Misat_Tub_SegII PF10644.9 KOG97541.1 - 3.6e-21 75.7 0.5 3.6e-21 75.7 0.5 1.9 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 KOG97541.1 - 0.00011 22.5 0.0 0.0025 18.0 0.0 2.6 3 0 0 3 3 3 1 Tubulin/FtsZ family, GTPase domain LIAS_N PF16881.5 KOG97542.1 - 0.089 13.2 0.0 0.76 10.2 0.0 2.6 2 0 0 2 2 2 0 N-terminal domain of lipoyl synthase of Radical_SAM family Myb_DNA-binding PF00249.31 KOG97543.1 - 1.4e-17 63.6 9.0 7.9e-09 35.6 0.5 3.8 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOG97543.1 - 6.4e-16 58.3 1.5 6.4e-10 39.1 0.7 3.8 2 1 1 3 3 3 2 Myb-like DNA-binding domain Myb_Cef PF11831.8 KOG97543.1 - 5.8e-08 32.6 5.0 5.8e-08 32.6 5.0 2.8 3 1 0 3 3 3 1 pre-mRNA splicing factor component Rap1_C PF11626.8 KOG97543.1 - 0.013 15.5 0.0 0.013 15.5 0.0 2.4 3 0 0 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MLTR_LBD PF17765.1 KOG97543.1 - 0.042 14.0 0.1 0.23 11.6 0.2 2.1 2 0 0 2 2 2 0 MmyB-like transcription regulator ligand binding domain PASTA PF03793.19 KOG97543.1 - 0.056 13.3 0.1 0.17 11.8 0.1 1.7 1 0 0 1 1 1 0 PASTA domain RAMP4 PF06624.12 KOG97543.1 - 2.9 8.0 5.5 20 5.3 5.7 2.3 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 DnaJ PF00226.31 KOG97544.1 - 5e-26 90.6 3.5 7.9e-26 90.0 3.5 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 KOG97544.1 - 6e-21 75.1 0.0 7.7e-21 74.7 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 KOG97544.1 - 2.7e-14 53.3 17.8 4.4e-14 52.6 17.8 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KOG97544.1 - 6.5e-08 32.4 6.8 9.1e-05 22.3 0.7 2.4 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein Haem_bd PF14376.6 KOG97544.1 - 0.13 12.2 0.3 1.4 8.9 0.1 2.3 2 0 0 2 2 2 0 Haem-binding domain Cytochrome_C7 PF14522.6 KOG97544.1 - 0.19 11.7 10.3 11 6.0 10.5 2.4 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c HypA PF01155.19 KOG97544.1 - 0.26 11.3 9.4 1.3 9.0 1.9 2.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrome_CBB3 PF13442.6 KOG97544.1 - 0.36 11.2 13.6 0.85 10.0 0.9 3.3 2 1 1 3 3 3 0 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 KOG97544.1 - 1.5 8.5 4.4 4.8 6.9 1.9 2.3 2 0 0 2 2 2 0 Cytochrome c-550 domain TackOD1 PF18551.1 KOG97544.1 - 2.3 7.9 7.2 0.91 9.2 1.2 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 Glyco_hydro_72 PF03198.14 KOG97545.1 - 3.5e-129 430.6 1.6 3.5e-129 430.6 1.6 1.3 2 0 0 2 2 2 1 Glucanosyltransferase Alpha_GJ PF03229.13 KOG97545.1 - 3.2 8.3 6.7 5.7 7.5 6.7 1.4 1 0 0 1 1 1 0 Alphavirus glycoprotein J Pkinase PF00069.25 KOG97546.1 - 4.7e-41 140.9 0.5 2.4e-19 69.8 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97546.1 - 1.4e-09 37.7 1.6 9.2e-07 28.4 0.7 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase GMP_synt_C PF00958.22 KOG97547.1 - 1.3e-44 150.2 0.0 2.6e-44 149.2 0.0 1.6 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 KOG97547.1 - 3.4e-41 141.1 0.0 6e-41 140.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 KOG97547.1 - 2.8e-09 36.4 0.0 1.2e-05 24.6 0.0 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 KOG97547.1 - 1.8e-05 24.6 0.1 0.00043 20.1 0.1 2.4 1 1 0 1 1 1 1 Peptidase C26 PAPS_reduct PF01507.19 KOG97547.1 - 0.0059 16.7 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family QueC PF06508.13 KOG97547.1 - 0.0062 16.0 0.0 0.16 11.4 0.0 2.2 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 KOG97547.1 - 0.015 14.1 0.1 0.035 12.9 0.1 1.6 2 0 0 2 2 2 0 tRNA methyl transferase Arginosuc_synth PF00764.19 KOG97547.1 - 0.033 13.5 0.1 0.057 12.7 0.1 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase ThiI PF02568.14 KOG97547.1 - 0.046 13.3 0.0 0.11 12.0 0.0 1.7 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) ATP_bind_3 PF01171.20 KOG97547.1 - 0.18 11.6 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 PP-loop family TRAPPC10 PF12584.8 KOG97548.1 - 1.5e-12 47.5 0.0 4.5e-12 45.9 0.0 1.8 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 MFS_1 PF07690.16 KOG97551.1 - 2.4e-10 39.9 28.4 2.8e-06 26.5 8.7 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily DUF2534 PF10749.9 KOG97551.1 - 0.17 12.1 3.5 0.18 12.0 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2534) FSH1 PF03959.13 KOG97552.1 - 6.4e-58 195.9 0.0 7.2e-58 195.7 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 KOG97552.1 - 7.4e-05 22.6 0.0 0.00077 19.3 0.0 2.2 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 KOG97552.1 - 0.0088 15.7 0.2 0.89 9.1 0.0 2.8 3 0 0 3 3 3 1 alpha/beta hydrolase fold BAAT_C PF08840.11 KOG97552.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal UCH PF00443.29 KOG97553.1 - 6.1e-58 196.3 6.0 7.9e-58 196.0 6.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOG97553.1 - 4.1e-20 72.6 9.4 4.1e-20 72.6 9.4 2.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KOG97553.1 - 1.5e-10 41.2 11.3 1.5e-10 41.2 11.3 3.5 3 1 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein Mre11_DNA_bind PF04152.14 KOG97554.1 - 5e-48 163.6 0.3 5e-48 163.6 0.3 2.0 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 KOG97554.1 - 8.8e-12 46.0 1.6 1.8e-11 44.9 1.6 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EcoR124_C PF12008.8 KOG97554.1 - 0.012 15.2 2.7 0.019 14.7 0.9 2.0 2 0 0 2 2 2 0 Type I restriction and modification enzyme - subunit R C terminal Metallophos_2 PF12850.7 KOG97554.1 - 0.046 13.9 0.0 0.53 10.4 0.0 2.6 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain adh_short PF00106.25 KOG97556.1 - 8.7e-54 181.9 0.1 1.2e-53 181.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOG97556.1 - 9.7e-34 116.9 0.1 1.2e-33 116.7 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOG97556.1 - 4.7e-12 46.2 0.0 6.9e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 KOG97556.1 - 0.012 14.8 0.2 0.035 13.2 0.2 1.9 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein UBA_4 PF14555.6 KOG97556.1 - 0.034 14.0 0.0 0.074 12.9 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain Sacchrp_dh_NADP PF03435.18 KOG97556.1 - 0.037 14.3 0.1 0.065 13.5 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain MreB_Mbl PF06723.13 KOG97556.1 - 0.049 12.4 0.1 0.091 11.6 0.1 1.4 1 0 0 1 1 1 0 MreB/Mbl protein DUF1776 PF08643.10 KOG97556.1 - 0.075 12.4 0.0 0.6 9.4 0.0 2.0 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) DUF1189 PF06691.11 KOG97556.1 - 0.2 11.2 0.6 0.3 10.6 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) TAFII55_N PF04658.13 KOG97557.1 - 8.8e-52 175.0 0.4 8.8e-52 175.0 0.4 3.7 3 1 0 3 3 3 1 TAFII55 protein conserved region RrnaAD PF00398.20 KOG97558.1 - 8.6e-79 264.3 0.0 9.8e-79 264.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase S1 PF00575.23 KOG97559.1 - 5.2e-57 190.1 32.8 1.7e-13 50.7 0.2 12.2 11 1 2 13 13 13 10 S1 RNA binding domain Suf PF05843.14 KOG97559.1 - 9.4e-07 29.1 20.9 0.0019 18.2 0.0 4.3 2 1 3 5 5 5 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 KOG97559.1 - 3.2e-05 24.3 0.0 0.79 10.3 0.0 3.5 2 1 0 3 3 3 2 Tetratricopeptide repeat RNase_II_C_S1 PF18614.1 KOG97559.1 - 0.0022 17.9 0.2 0.44 10.5 0.2 3.2 2 0 0 2 2 2 1 RNase II-type exonuclease C-terminal S1 domain TPR_14 PF13428.6 KOG97559.1 - 0.0042 17.8 2.6 4.3 8.4 0.0 4.2 2 1 3 5 5 5 1 Tetratricopeptide repeat DUF1205 PF06722.12 KOG97559.1 - 0.22 11.6 1.0 3.1 8.0 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1205) CsrA PF02599.16 KOG97559.1 - 0.36 10.8 2.2 7.5 6.6 0.1 4.0 4 0 0 4 4 4 0 Global regulator protein family S10_plectin PF03501.15 KOG97560.1 - 3.2e-43 145.7 1.1 3.7e-43 145.5 1.1 1.0 1 0 0 1 1 1 1 Plectin/S10 domain DUF4364 PF14277.6 KOG97560.1 - 0.016 15.0 0.5 0.025 14.3 0.3 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4364) tRNA-synt_1c_C PF03950.18 KOG97560.1 - 0.038 13.9 0.1 0.042 13.7 0.1 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), anti-codon binding domain Replic_Relax PF13814.6 KOG97560.1 - 0.053 13.6 0.1 0.058 13.4 0.1 1.2 1 0 0 1 1 1 0 Replication-relaxation HTH_45 PF14947.6 KOG97560.1 - 0.059 13.4 0.7 0.089 12.8 0.3 1.5 2 0 0 2 2 2 0 Winged helix-turn-helix PadR PF03551.14 KOG97560.1 - 0.064 13.2 0.4 0.064 13.2 0.4 1.7 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family MsyB PF13984.6 KOG97560.1 - 0.08 13.3 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 MsyB protein VPS11_C PF12451.8 KOG97561.1 - 2.1e-12 47.0 0.1 5.1e-12 45.8 0.1 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 KOG97561.1 - 2.1e-05 24.5 8.2 7.3e-05 22.7 8.2 2.0 1 1 0 1 1 1 1 Zinc-finger zf-RING_UBOX PF13445.6 KOG97561.1 - 5.2e-05 23.2 3.9 5.2e-05 23.2 3.9 2.0 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOG97561.1 - 0.00028 20.7 5.0 0.0012 18.7 5.0 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOG97561.1 - 0.0036 17.6 5.5 0.012 15.9 5.5 1.9 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 KOG97561.1 - 0.0038 17.2 1.7 0.0086 16.1 1.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 KOG97561.1 - 0.0053 17.0 3.2 0.0053 17.0 3.2 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KOG97561.1 - 0.0072 16.3 8.7 0.029 14.3 6.2 2.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOG97561.1 - 0.0084 16.0 6.1 0.039 13.8 6.1 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 KOG97561.1 - 0.012 15.5 3.9 0.012 15.5 3.9 2.0 2 0 0 2 2 1 0 PHD-finger Zn_ribbon_17 PF17120.5 KOG97561.1 - 0.04 13.5 2.3 0.11 12.2 2.3 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 KOG97561.1 - 0.044 13.9 5.3 0.21 11.7 5.3 2.3 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Clathrin PF00637.20 KOG97561.1 - 0.23 11.3 9.9 0.68 9.8 2.9 3.9 2 2 1 3 3 3 0 Region in Clathrin and VPS FANCL_C PF11793.8 KOG97561.1 - 0.45 10.7 2.5 1.1 9.5 2.5 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain Prok-RING_1 PF14446.6 KOG97561.1 - 0.56 10.2 4.1 0.27 11.2 1.3 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 zf-C3HC4_3 PF13920.6 KOG97561.1 - 1.4 8.8 6.7 0.39 10.6 3.2 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pex19 PF04614.12 KOG97561.1 - 2.2 8.0 4.3 10 5.8 0.7 2.3 2 0 0 2 2 2 0 Pex19 protein family zf-RING_11 PF17123.5 KOG97561.1 - 4.2 7.2 11.0 0.22 11.3 3.1 3.0 4 0 0 4 4 4 0 RING-like zinc finger RhoGEF PF00621.20 KOG97562.1 - 1e-10 42.2 3.9 1e-10 42.2 3.9 3.0 2 1 1 3 3 3 1 RhoGEF domain SWIB PF02201.18 KOG97563.1 - 1.1e-31 108.5 0.4 4.1e-30 103.5 0.3 2.4 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.11 KOG97563.1 - 1.5e-10 40.8 0.0 2.1e-09 37.2 0.0 2.6 2 0 0 2 2 2 1 DEK C terminal domain RNase_H PF00075.24 KOG97564.1 - 3.7e-34 118.0 0.5 6.7e-34 117.1 0.1 1.7 2 0 0 2 2 2 1 RNase H Cauli_VI PF01693.16 KOG97564.1 - 6.6e-29 99.9 9.1 1.8e-19 69.7 2.0 2.5 2 0 0 2 2 2 2 Caulimovirus viroplasmin RVT_3 PF13456.6 KOG97564.1 - 0.06 13.2 0.1 0.29 10.9 0.0 2.0 1 1 1 2 2 2 0 Reverse transcriptase-like PilM_2 PF11104.8 KOG97564.1 - 0.13 11.2 0.1 0.19 10.7 0.1 1.2 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; LRR_6 PF13516.6 KOG97565.1 - 1.3e-06 27.9 6.1 2.7 8.3 0.0 6.9 7 0 0 7 7 7 2 Leucine Rich repeat LRR_4 PF12799.7 KOG97565.1 - 6.7e-06 26.3 18.4 2.2 8.9 0.2 7.1 4 3 3 8 8 8 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOG97565.1 - 0.069 13.7 9.1 1.2e+02 3.8 0.1 6.4 6 1 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 KOG97565.1 - 0.19 11.5 15.6 8.1 6.3 0.1 5.9 4 2 0 4 4 4 0 Leucine rich repeat NOA36 PF06524.12 KOG97565.1 - 0.69 9.2 7.5 0.93 8.8 7.5 1.2 1 0 0 1 1 1 0 NOA36 protein TFIID-31kDa PF02291.15 KOG97566.1 - 2.1e-48 163.4 0.0 2.5e-48 163.2 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit ChAPs PF09295.10 KOG97567.1 - 1.9e-172 573.7 4.0 2.4e-172 573.4 4.0 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) Glyco_hydro_76 PF03663.14 KOG97568.1 - 8.1e-154 512.5 16.2 9.7e-154 512.3 16.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 KOG97568.1 - 0.013 14.6 7.9 0.45 9.5 0.5 3.1 1 1 0 2 2 2 0 Glycosyl Hydrolase Family 88 RNase_3_N PF18497.1 KOG97569.1 - 5.8e-43 145.5 4.7 1.4e-42 144.2 4.7 1.7 1 0 0 1 1 1 1 Ribonuclease III N-terminal domain Ribonuclease_3 PF00636.26 KOG97569.1 - 5e-18 65.6 0.9 1.3e-17 64.3 0.0 2.2 2 1 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 KOG97569.1 - 7e-14 52.1 0.0 1.8e-13 50.7 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.26 KOG97569.1 - 1e-06 29.3 0.0 2.9e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 Double-stranded RNA binding motif DUF5600 PF18150.1 KOG97569.1 - 0.74 10.4 5.1 6.2 7.4 1.8 3.4 2 2 0 2 2 2 0 Domain of unknown function (DUF5600) DUF382 PF04037.13 KOG97570.1 - 1e-50 171.1 0.7 2.3e-50 170.0 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 KOG97570.1 - 1e-22 79.7 1.8 1.7e-22 79.0 1.8 1.4 1 0 0 1 1 1 1 PSP hGDE_central PF14702.6 KOG97570.1 - 0.24 11.1 2.2 0.43 10.2 2.2 1.4 1 0 0 1 1 1 0 Central domain of human glycogen debranching enzyme Mito_carr PF00153.27 KOG97571.1 - 4.9e-29 100.1 3.8 2.5e-13 49.7 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L18A PF01775.17 KOG97572.1 - 1.2e-42 144.9 2.7 1.8e-42 144.3 2.7 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Cation_efflux PF01545.21 KOG97573.1 - 1e-55 188.6 1.6 1.4e-55 188.1 1.6 1.2 1 0 0 1 1 1 1 Cation efflux family SUN PF03856.13 KOG97574.1 - 1.5e-79 267.0 18.1 1.8e-79 266.7 18.1 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) COX6B PF02297.17 KOG97575.1 - 1e-22 80.1 3.0 1.4e-22 79.7 3.0 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb AMP-binding PF00501.28 KOG97576.1 - 3.1e-84 283.0 0.0 4.5e-84 282.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOG97576.1 - 0.0011 19.9 0.6 0.0033 18.4 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DUF1488 PF07369.11 KOG97576.1 - 0.18 11.8 0.0 0.86 9.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1488) zf-RING_2 PF13639.6 KOG97577.1 - 5.6e-07 29.8 7.3 1.3e-06 28.7 7.3 1.6 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 KOG97577.1 - 1.8e-05 24.8 4.3 5e-05 23.4 4.3 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 KOG97577.1 - 0.00013 22.2 6.8 0.00028 21.1 6.8 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KOG97577.1 - 0.00046 20.2 1.7 0.0012 18.9 1.7 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 KOG97577.1 - 0.018 14.9 7.7 0.035 14.0 7.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOG97577.1 - 0.049 13.5 7.1 0.099 12.5 7.1 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 KOG97577.1 - 0.057 13.7 6.8 0.11 12.8 6.8 1.5 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_3 PF13920.6 KOG97577.1 - 0.064 13.1 4.9 2.6 8.0 4.9 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 KOG97577.1 - 0.08 13.1 5.7 0.16 12.1 5.7 1.5 1 0 0 1 1 1 0 RING-variant domain Zn_ribbon_17 PF17120.5 KOG97577.1 - 0.22 11.2 3.7 0.46 10.2 3.7 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-UDP PF14569.6 KOG97577.1 - 1.5 9.0 3.2 19 5.4 0.6 2.5 1 1 1 2 2 2 0 Zinc-binding RING-finger PHD PF00628.29 KOG97577.1 - 4 7.4 5.9 7.5 6.5 5.9 1.5 1 0 0 1 1 1 0 PHD-finger Prok-RING_4 PF14447.6 KOG97577.1 - 6.8 6.6 7.3 2.3 8.1 0.5 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Pyridoxal_deC PF00282.19 KOG97578.1 - 9e-55 185.9 0.0 1.6e-54 185.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain GST_N_2 PF13409.6 KOG97579.1 - 6.7e-23 80.8 0.1 2.8e-22 78.8 0.0 2.1 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOG97579.1 - 3.3e-13 49.5 0.0 6.3e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOG97579.1 - 7.7e-06 26.0 0.1 1.5e-05 25.1 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOG97579.1 - 0.1 12.8 0.2 0.45 10.7 0.2 2.0 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SR-25 PF10500.9 KOG97581.1 - 0.056 13.1 1.4 0.067 12.8 1.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein EamA PF00892.20 KOG97582.1 - 1e-26 93.8 29.6 2e-16 60.4 6.3 2.2 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 KOG97582.1 - 0.00071 18.6 7.5 0.001 18.1 7.5 1.3 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like SLC35F PF06027.12 KOG97582.1 - 0.00094 18.8 12.2 0.0014 18.2 12.2 1.3 1 0 0 1 1 1 1 Solute carrier family 35 UPF0060 PF02694.15 KOG97582.1 - 0.061 13.6 10.2 3.6 7.8 5.3 3.1 2 1 1 3 3 3 0 Uncharacterised BCR, YnfA/UPF0060 family DUF2070 PF09843.9 KOG97582.1 - 3.6 5.8 20.6 1.8 6.8 7.1 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) GFD1 PF17331.2 KOG97583.1 - 9.2e-07 28.9 13.3 2.3e-06 27.6 13.3 1.8 1 0 0 1 1 1 1 GFD1 mRNA transport factor SOG2 PF10428.9 KOG97583.1 - 0.96 8.6 14.7 1 8.5 14.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF4551 PF15087.6 KOG97583.1 - 2 7.1 23.2 2.5 6.8 23.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CDC45 PF02724.14 KOG97583.1 - 6.9 4.8 14.3 9.2 4.4 14.3 1.2 1 0 0 1 1 1 0 CDC45-like protein COX7a PF02238.15 KOG97584.1 - 5.6e-23 81.1 0.4 6.2e-23 80.9 0.4 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Spc29 PF17082.5 KOG97585.1 - 0.075 12.9 3.1 0.2 11.5 0.9 2.3 2 0 0 2 2 2 0 Spindle Pole Component 29 RPN7 PF10602.9 KOG97585.1 - 0.4 10.4 5.6 0.49 10.1 0.5 3.2 3 1 0 3 3 3 0 26S proteasome subunit RPN7 F-box-like PF12937.7 KOG97586.1 - 5.4e-05 23.0 0.0 0.00017 21.4 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOG97586.1 - 0.024 14.5 0.0 0.084 12.8 0.0 2.0 1 0 0 1 1 1 0 F-box domain DUF2428 PF10350.9 KOG97587.1 - 1.4e-44 152.4 0.0 3.8e-44 151.0 0.0 1.8 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 KOG97587.1 - 0.00096 19.2 0.1 0.26 11.7 0.0 4.0 3 0 0 3 3 3 1 HEAT repeat eIF-1a PF01176.19 KOG97588.1 - 4.9e-20 71.1 0.0 6.9e-20 70.6 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Glyco_transf_20 PF00982.21 KOG97589.1 - 7.2e-178 592.1 3.0 7.2e-178 592.1 3.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 KOG97589.1 - 1.7e-47 161.5 0.0 3.5e-47 160.5 0.0 1.5 1 0 0 1 1 1 1 Trehalose-phosphatase Foie-gras_1 PF11817.8 KOG97589.1 - 0.45 10.1 2.2 0.43 10.1 0.8 1.6 2 0 0 2 2 2 0 Foie gras liver health family 1 TatD_DNase PF01026.21 KOG97590.1 - 1.6e-47 162.0 0.0 1.8e-47 161.9 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase SAP30_Sin3_bdg PF13867.6 KOG97591.1 - 1.2e-10 41.5 1.0 6.7e-07 29.6 0.3 2.4 2 0 0 2 2 2 2 Sin3 binding region of histone deacetylase complex subunit SAP30 Menin PF05053.13 KOG97591.1 - 0.074 11.4 4.6 0.079 11.3 4.6 1.1 1 0 0 1 1 1 0 Menin Cue1_U7BR PF18499.1 KOG97592.1 - 5.5e-27 93.6 5.2 5.5e-27 93.6 5.2 1.6 2 0 0 2 2 2 1 Ubc7p-binding region of Cue1 CUE PF02845.16 KOG97592.1 - 1.1e-11 44.2 0.0 1.8e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 CUE domain SelK_SelG PF10961.8 KOG97592.1 - 1.1 10.0 4.9 1.4 9.6 0.3 2.2 2 0 0 2 2 2 0 Selenoprotein SelK_SelG HAD_SAK_1 PF10307.9 KOG97593.1 - 3.8e-54 183.6 0.0 6.7e-54 182.8 0.0 1.4 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins RSN1_7TM PF02714.15 KOG97594.1 - 1.4e-89 300.1 23.1 1.4e-89 300.1 23.1 2.1 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 KOG97594.1 - 4.4e-40 137.0 1.2 4.4e-40 137.0 1.2 2.8 5 0 0 5 5 5 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 KOG97594.1 - 5.2e-31 108.2 0.3 8.1e-31 107.6 0.3 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 KOG97594.1 - 3.6e-25 88.0 1.9 3.8e-25 87.9 0.1 2.1 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter Tegument_dsDNA PF12818.7 KOG97594.1 - 0.021 14.0 0.2 0.035 13.2 0.2 1.2 1 0 0 1 1 1 0 dsDNA viral tegument protein Pyrophosphatase PF00719.19 KOG97595.1 - 3.3e-52 176.5 0.0 4.4e-52 176.1 0.0 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase RRM_1 PF00076.22 KOG97596.1 - 2.9e-41 139.1 4.4 9e-14 51.1 0.1 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOG97596.1 - 5.8e-29 99.8 0.1 2.3e-25 88.2 0.1 3.5 3 0 0 3 3 3 2 Occluded RNA-recognition motif Lsm_interact PF05391.11 KOG97596.1 - 3.8e-10 38.9 1.3 1.1e-09 37.4 1.3 1.9 1 0 0 1 1 1 1 Lsm interaction motif Nup35_RRM_2 PF14605.6 KOG97596.1 - 5.5e-07 29.5 0.1 0.018 15.0 0.0 2.8 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 KOG97596.1 - 0.0006 20.1 6.7 0.92 9.7 0.0 4.9 4 2 1 5 5 5 1 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM PF05172.13 KOG97596.1 - 0.055 13.4 0.0 0.93 9.5 0.0 2.6 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DbpA PF03880.15 KOG97596.1 - 0.12 12.3 0.5 13 5.9 0.1 2.9 2 1 0 2 2 2 0 DbpA RNA binding domain G-patch PF01585.23 KOG97597.1 - 0.034 14.0 2.6 0.37 10.7 2.6 2.6 1 1 0 1 1 1 0 G-patch domain Neur_chan_memb PF02932.16 KOG97597.1 - 0.29 11.2 6.4 0.31 11.1 6.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 KOG97597.1 - 0.47 10.2 18.9 0.54 10.0 18.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MCM_bind PF09739.9 KOG97597.1 - 1.8 6.9 17.0 2.2 6.6 17.0 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CRT10 PF08728.10 KOG97597.1 - 5.8 5.0 12.0 6 4.9 12.0 1.0 1 0 0 1 1 1 0 CRT10 RRN9 PF10680.9 KOG97598.1 - 2.5e-17 62.9 0.6 6.4e-17 61.6 0.6 1.7 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor Pribosyltran PF00156.27 KOG97599.1 - 4.3e-14 52.3 0.1 6.1e-14 51.8 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Cyt-b5 PF00173.28 KOG97601.1 - 7.2e-22 77.3 0.4 2.4e-21 75.6 0.2 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 KOG97601.1 - 6.9e-14 52.3 13.8 6.9e-14 52.3 13.8 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily CIDE-N PF02017.15 KOG97601.1 - 0.012 15.7 0.1 0.023 14.7 0.1 1.4 1 0 0 1 1 1 0 CIDE-N domain Anth_synt_I_N PF04715.13 KOG97601.1 - 0.072 13.3 0.2 0.15 12.3 0.2 1.5 1 0 0 1 1 1 0 Anthranilate synthase component I, N terminal region Zds_C PF08632.10 KOG97602.1 - 1.5e-29 101.5 2.5 2.9e-29 100.6 2.5 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term CPBP PF02517.16 KOG97603.1 - 2.2e-13 50.4 6.6 2.2e-13 50.4 6.6 2.1 2 1 0 2 2 2 1 CPBP intramembrane metalloprotease Bul1_N PF04425.12 KOG97604.1 - 7.1e-169 562.3 0.1 7.1e-169 562.3 0.1 1.9 2 0 0 2 2 2 1 Bul1 N terminus Bul1_C PF04426.12 KOG97604.1 - 1.5e-115 385.3 10.5 1.5e-115 385.3 10.5 2.2 2 0 0 2 2 2 1 Bul1 C terminus ubiquitin PF00240.23 KOG97605.1 - 3.1e-24 84.5 0.1 4.5e-24 84.0 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KOG97605.1 - 1.9e-11 43.6 0.0 3.1e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 KOG97605.1 - 6.3e-05 22.8 0.3 0.00017 21.4 0.0 2.0 2 0 0 2 2 2 1 UBA/TS-N domain Ubiquitin_2 PF14560.6 KOG97605.1 - 7.1e-05 23.2 0.0 0.00016 22.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 KOG97605.1 - 0.0001 22.4 0.0 0.00028 21.0 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like HOIP-UBA PF16678.5 KOG97605.1 - 0.01 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 HOIP UBA domain pair TBK1_ULD PF18396.1 KOG97605.1 - 0.014 15.3 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain GerD PF17898.1 KOG97605.1 - 0.024 14.6 7.7 0.043 13.8 7.7 1.4 1 0 0 1 1 1 0 Spore germination GerD central core domain Ubiquitin_4 PF18036.1 KOG97605.1 - 0.047 13.7 0.1 12 6.0 0.0 2.2 1 1 1 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 KOG97605.1 - 0.11 13.1 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain NIF PF03031.18 KOG97606.1 - 4.4e-23 81.8 0.4 6.4e-22 78.0 0.0 3.0 2 2 1 3 3 3 1 NLI interacting factor-like phosphatase BRCT PF00533.26 KOG97606.1 - 5.3e-13 49.2 0.6 1.6e-12 47.7 0.1 2.1 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 KOG97606.1 - 8.9e-07 28.8 0.0 1.9e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 KOG97606.1 - 0.0052 17.2 0.0 0.015 15.7 0.0 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 KOG97606.1 - 0.071 13.4 0.9 0.12 12.7 0.1 1.8 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain ATP-synt_J PF04911.12 KOG97606.1 - 0.1 12.2 0.3 0.22 11.1 0.3 1.5 1 0 0 1 1 1 0 ATP synthase j chain Maf1 PF09174.10 KOG97606.1 - 5.4 7.1 8.1 0.49 10.5 3.1 1.8 2 0 0 2 2 2 0 Maf1 regulator Exonuc_VII_L PF02601.15 KOG97606.1 - 7.8 6.0 10.7 12 5.3 8.4 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit PGM_PMM_I PF02878.16 KOG97607.1 - 4.6e-40 136.5 0.1 1.3e-39 135.0 0.0 1.7 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 KOG97607.1 - 3.2e-19 69.5 0.0 8.1e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 KOG97607.1 - 3.7e-12 46.4 0.0 6e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 KOG97607.1 - 7.3e-06 26.1 0.0 1.7e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain MFS_1 PF07690.16 KOG97608.1 - 1.1e-35 123.2 52.8 5.5e-34 117.6 52.8 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG97608.1 - 1.4e-05 24.2 1.6 1.4e-05 24.2 1.6 4.1 3 1 0 4 4 4 3 Sugar (and other) transporter Cadherin_C_2 PF16492.5 KOG97608.1 - 0.45 11.3 3.1 1.7 9.5 3.1 2.0 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Fungal_trans PF04082.18 KOG97609.1 - 4.9e-43 147.1 3.0 4.9e-43 147.1 3.0 3.1 3 0 0 3 3 3 2 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG97609.1 - 1.1e-10 41.5 12.1 2.1e-10 40.5 12.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain bZIP_2 PF07716.15 KOG97609.1 - 0.09 12.9 2.2 0.084 13.0 0.3 1.9 2 0 0 2 2 2 0 Basic region leucine zipper bZIP_1 PF00170.21 KOG97609.1 - 1.1 9.4 5.1 0.18 11.9 0.3 2.2 2 0 0 2 2 2 0 bZIP transcription factor PIG-L PF02585.17 KOG97610.1 - 4.3e-19 69.5 0.0 6.8e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DUF4492 PF14899.6 KOG97610.1 - 0.11 12.4 1.6 0.4 10.6 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4492) ATP13 PF12921.7 KOG97611.1 - 2e-26 92.1 0.4 1.3e-25 89.5 0.0 2.7 3 0 0 3 3 3 1 Mitochondrial ATPase expression Phage_min_tail PF05939.13 KOG97611.1 - 0.11 12.9 0.4 3.9 7.9 0.0 2.9 3 0 0 3 3 3 0 Phage minor tail protein Rit1_C PF17184.4 KOG97612.1 - 3.3e-97 325.2 0.1 1.4e-96 323.1 0.0 1.8 2 0 0 2 2 2 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 KOG97612.1 - 6.4e-26 90.8 0.7 1.6e-25 89.5 0.1 2.0 2 0 0 2 2 2 1 Rit1 DUSP-like domain Ku_N PF03731.15 KOG97613.1 - 1.4e-51 175.3 1.2 2.6e-51 174.5 1.2 1.4 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.16 KOG97613.1 - 4.7e-31 108.1 0.1 8.5e-31 107.3 0.1 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.14 KOG97613.1 - 9.8e-11 42.2 1.4 2.8e-10 40.8 1.1 2.0 1 1 0 1 1 1 1 Ku70/Ku80 C-terminal arm VWA PF00092.28 KOG97613.1 - 0.0016 18.7 0.0 0.017 15.4 0.0 2.2 1 1 0 1 1 1 1 von Willebrand factor type A domain Exo_endo_phos PF03372.23 KOG97614.1 - 5.2e-35 121.1 0.0 8.2e-35 120.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ribosomal_L30 PF00327.20 KOG97615.1 - 1.6e-14 53.5 0.7 3.3e-14 52.5 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e GTP-bdg_N PF13167.6 KOG97615.1 - 0.11 13.2 0.1 0.13 12.9 0.1 1.3 1 1 0 1 1 1 0 GTP-binding GTPase N-terminal RNB PF00773.19 KOG97616.1 - 5.4e-71 239.6 0.0 1.2e-70 238.4 0.0 1.6 1 0 0 1 1 1 1 RNB domain HEAT PF02985.22 KOG97617.1 - 3.7e-08 33.0 5.3 12 6.5 0.0 8.5 10 0 0 10 10 10 2 HEAT repeat HEAT_2 PF13646.6 KOG97617.1 - 8.2e-08 32.5 4.2 1.7 9.1 0.0 7.3 4 2 6 10 10 10 3 HEAT repeats Cnd1 PF12717.7 KOG97617.1 - 4e-06 27.0 5.6 4.2 7.4 0.0 6.6 4 2 1 6 6 6 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KOG97617.1 - 1.6e-05 25.3 0.6 3.7 8.2 0.0 6.7 7 0 0 7 7 7 1 HEAT-like repeat DUF3385 PF11865.8 KOG97617.1 - 2.2e-05 24.4 2.0 0.97 9.3 0.0 4.9 2 1 3 5 5 5 2 Domain of unknown function (DUF3385) Adaptin_N PF01602.20 KOG97617.1 - 0.00024 19.8 3.7 0.005 15.4 0.7 2.7 3 0 0 3 3 3 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 KOG97617.1 - 0.0017 18.9 0.2 0.64 10.6 0.0 4.6 4 2 2 6 6 6 1 Vacuolar 14 Fab1-binding region NUC173 PF08161.12 KOG97617.1 - 0.06 13.0 1.3 0.64 9.6 0.0 3.4 4 1 2 6 6 6 0 NUC173 domain Aminotran_4 PF01063.19 KOG97618.1 - 6.5e-22 78.5 0.0 1.6e-21 77.2 0.0 1.5 1 1 0 1 1 1 1 Amino-transferase class IV TAXi_N PF14543.6 KOG97618.1 - 0.14 12.4 1.2 2.4 8.4 1.2 2.3 1 1 0 1 1 1 0 Xylanase inhibitor N-terminal DEAD PF00270.29 KOG97619.1 - 3.5e-46 157.2 0.5 9.1e-46 155.8 0.0 2.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG97619.1 - 1.9e-25 89.4 0.1 1.5e-24 86.5 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KOG97619.1 - 2.6e-19 69.2 0.5 4.7e-19 68.4 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KOG97619.1 - 5.3e-06 26.6 0.0 1.3e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOG97619.1 - 0.00015 21.1 0.0 0.00042 19.6 0.0 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SecA_DEAD PF07517.14 KOG97619.1 - 0.0022 17.3 0.0 0.0066 15.8 0.0 1.7 1 1 0 1 1 1 1 SecA DEAD-like domain AAA_30 PF13604.6 KOG97619.1 - 0.17 11.5 0.0 1 9.1 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOG97619.1 - 0.2 11.9 2.6 0.65 10.3 1.4 2.6 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.25 KOG97620.1 - 3.8e-48 164.1 1.5 8.1e-47 159.8 0.7 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97620.1 - 2.3e-24 86.1 0.5 9.2e-22 77.6 0.3 3.1 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOG97620.1 - 0.00024 20.0 0.3 0.00072 18.4 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KOG97620.1 - 0.013 14.8 0.4 1 8.6 0.0 2.5 2 0 0 2 2 2 0 Kinase-like Got1 PF04178.12 KOG97621.1 - 9.9e-13 48.5 6.2 1.2e-12 48.2 6.2 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family YrhK PF14145.6 KOG97621.1 - 0.12 12.3 9.1 2.3 8.2 3.2 2.6 1 1 1 2 2 2 0 YrhK-like protein PhaG_MnhG_YufB PF03334.14 KOG97621.1 - 0.38 11.0 6.0 3.5 7.9 6.0 2.4 1 1 0 1 1 1 0 Na+/H+ antiporter subunit Amidase PF01425.21 KOG97622.1 - 7.5e-133 443.8 0.0 8.4e-133 443.6 0.0 1.0 1 0 0 1 1 1 1 Amidase Dynamitin PF04912.14 KOG97623.1 - 2.1e-13 50.4 24.8 7.4e-12 45.3 24.7 2.4 1 1 0 1 1 1 1 Dynamitin HSBP1 PF06825.12 KOG97623.1 - 0.00016 21.4 3.1 0.00016 21.4 3.1 3.7 5 1 1 6 6 6 1 Heat shock factor binding protein 1 DUF5082 PF16888.5 KOG97623.1 - 0.0017 18.6 6.2 0.0017 18.6 6.2 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF5082) DASH_Dam1 PF08653.10 KOG97623.1 - 0.14 12.0 6.2 1.4 8.8 0.0 4.2 5 0 0 5 5 5 0 DASH complex subunit Dam1 FUSC PF04632.12 KOG97623.1 - 0.69 8.4 1.4 1.3 7.5 0.1 1.8 2 0 0 2 2 2 0 Fusaric acid resistance protein family Kinesin_assoc PF16183.5 KOG97623.1 - 1.4 9.0 8.5 1.6 8.9 3.9 2.7 1 1 1 2 2 2 0 Kinesin-associated Bacillus_HBL PF05791.11 KOG97623.1 - 5.6 6.7 20.7 0.059 13.2 5.4 3.2 3 1 1 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) FlaC_arch PF05377.11 KOG97623.1 - 6.3 7.3 15.5 7.2 7.1 0.5 5.4 3 1 2 5 5 5 0 Flagella accessory protein C (FlaC) Baculo_PEP_C PF04513.12 KOG97623.1 - 8.3 6.4 8.1 3.1 7.8 2.7 2.8 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2406 PF10295.9 KOG97624.1 - 1.4e-27 96.1 0.1 3.3e-27 95.0 0.1 1.6 1 0 0 1 1 1 1 Uncharacterised protein (DUF2406) DUF3484 PF11983.8 KOG97624.1 - 0.023 15.8 2.3 0.03 15.4 0.6 2.1 2 1 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch Aminotran_1_2 PF00155.21 KOG97625.1 - 8.1e-83 278.6 0.0 9.7e-83 278.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Peptidase_S10 PF00450.22 KOG97626.1 - 5.3e-128 428.0 0.3 6.6e-128 427.7 0.3 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 KOG97626.1 - 2.8e-22 79.6 1.6 4.8e-21 75.6 1.6 2.5 1 1 0 1 1 1 1 Carboxypeptidase Y pro-peptide DLIC PF05783.11 KOG97628.1 - 1.5e-05 24.1 0.1 2.2e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) GATase_6 PF13522.6 KOG97629.1 - 4.5e-13 49.5 0.1 1.3e-12 48.0 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KOG97629.1 - 1.1e-09 38.3 0.0 2.2e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 KOG97629.1 - 8.2e-09 35.2 0.0 1.4e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 KOG97629.1 - 8.5e-05 21.6 0.0 0.00014 20.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II ABC_membrane PF00664.23 KOG97630.1 - 4e-45 154.6 12.7 5e-45 154.3 12.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KOG97630.1 - 1.1e-35 123.1 0.0 2.3e-35 122.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KOG97630.1 - 5.4e-07 29.3 0.0 0.0013 18.3 0.0 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOG97630.1 - 0.00098 18.8 0.5 0.0023 17.6 0.5 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_ATPase PF09818.9 KOG97630.1 - 0.0051 15.7 0.0 0.3 9.8 0.0 2.2 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_16 PF13191.6 KOG97630.1 - 0.015 15.7 0.0 0.032 14.6 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_21 PF13304.6 KOG97630.1 - 0.017 15.0 0.1 0.058 13.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 KOG97630.1 - 0.027 14.7 0.0 0.17 12.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 KOG97630.1 - 0.04 13.6 0.8 0.061 13.0 0.1 1.7 2 0 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 KOG97630.1 - 0.096 12.8 0.1 0.31 11.1 0.1 1.9 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_23 PF13476.6 KOG97630.1 - 0.1 13.1 0.6 0.35 11.3 0.2 2.0 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KOG97630.1 - 0.12 11.7 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 KOG97630.1 - 0.12 12.0 0.0 0.39 10.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 KOG97630.1 - 0.13 12.5 0.4 0.73 10.1 0.4 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Gtr1_RagA PF04670.12 KOG97630.1 - 0.13 11.6 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_25 PF13481.6 KOG97630.1 - 0.17 11.4 0.0 0.54 9.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain RNA12 PF10443.9 KOG97631.1 - 2.1e-180 600.2 4.6 3.8e-179 596.1 1.9 2.2 2 0 0 2 2 2 2 RNA12 protein RRM_1 PF00076.22 KOG97631.1 - 2.6e-08 33.6 0.0 6.6e-08 32.3 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATPase_2 PF01637.18 KOG97631.1 - 0.00012 22.1 0.2 0.00012 22.1 0.2 3.1 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 KOG97631.1 - 0.0039 17.2 0.0 0.02 14.9 0.0 2.2 1 0 0 1 1 1 1 AAA domain ADH_N PF08240.12 KOG97632.1 - 1.4e-29 102.2 0.3 1.4e-29 102.2 0.3 1.9 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOG97632.1 - 7.7e-25 87.4 1.3 1.2e-24 86.8 1.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOG97632.1 - 4.1e-06 27.9 0.1 7.3e-06 27.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase USP7_C2 PF14533.6 KOG97633.1 - 5.1e-59 199.4 4.1 6.4e-58 195.8 1.1 3.3 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 KOG97633.1 - 1.6e-44 152.4 2.7 2.8e-44 151.6 2.7 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 KOG97633.1 - 2.4e-30 105.6 3.2 6.3e-29 101.0 0.1 3.2 2 2 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.6 KOG97633.1 - 3.6e-22 79.4 0.1 2.7e-21 76.5 0.1 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UN_NPL4 PF11543.8 KOG97633.1 - 0.65 10.5 4.5 2.1 8.9 0.3 3.7 3 1 1 4 4 4 0 Nuclear pore localisation protein NPL4 Glyco_hydro_17 PF00332.18 KOG97634.1 - 2.9e-12 46.8 3.0 5.4e-12 45.9 1.8 1.9 1 1 1 2 2 2 1 Glycosyl hydrolases family 17 Hamartin PF04388.12 KOG97634.1 - 0.16 10.7 3.8 0.16 10.6 3.8 1.1 1 0 0 1 1 1 0 Hamartin protein Macoilin PF09726.9 KOG97634.1 - 0.16 10.5 7.0 0.2 10.2 7.0 1.2 1 0 0 1 1 1 0 Macoilin family CCDC24 PF15669.5 KOG97634.1 - 1.1 9.1 7.5 1.9 8.3 7.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Apt1 PF10351.9 KOG97634.1 - 1.2 7.9 5.2 1.4 7.7 5.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain RAP1 PF07218.11 KOG97634.1 - 1.6 6.9 16.4 2.9 6.0 16.4 1.5 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Basic PF01586.16 KOG97635.1 - 3.9 8.7 9.0 1.2e+02 3.9 9.0 2.7 1 1 0 1 1 1 0 Myogenic Basic domain Glucan_synthase PF02364.15 KOG97636.1 - 0 1372.1 0.1 0 1372.1 0.1 2.1 1 1 1 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 KOG97636.1 - 1.7e-44 151.3 1.8 6.8e-44 149.3 1.8 2.1 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Glyco_hydro_72 PF03198.14 KOG97637.1 - 5.2e-148 492.4 13.7 7e-148 492.0 13.7 1.2 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 KOG97637.1 - 5.2e-29 100.7 6.4 2.3e-28 98.7 6.4 2.2 1 0 0 1 1 1 1 X8 domain Ribosomal_L7Ae PF01248.26 KOG97637.1 - 0.068 12.9 0.1 0.19 11.5 0.1 1.7 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Apt1 PF10351.9 KOG97637.1 - 0.32 9.8 4.3 0.45 9.3 4.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4692 PF15763.5 KOG97637.1 - 0.75 10.2 8.5 2.3 8.7 8.5 1.9 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Corona_nucleoca PF00937.18 KOG97637.1 - 4.1 6.3 12.0 6.9 5.6 12.0 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Importin_rep_6 PF18829.1 KOG97638.1 - 1e-46 157.5 1.7 1e-46 157.5 1.7 4.0 3 0 0 3 3 3 1 Importin repeat 6 Importin_rep_4 PF18808.1 KOG97638.1 - 3.6e-34 116.9 1.0 3.6e-34 116.9 1.0 3.2 3 0 0 3 3 2 1 Importin repeat HEAT_EZ PF13513.6 KOG97638.1 - 5.2e-23 81.1 3.2 8.6e-11 42.1 0.0 8.2 6 1 2 8 8 8 3 HEAT-like repeat Importin_rep_5 PF18816.1 KOG97638.1 - 2e-22 79.2 4.5 2.1e-22 79.2 0.1 3.3 3 0 0 3 3 3 1 Importin repeat HEAT PF02985.22 KOG97638.1 - 1.1e-14 53.3 5.3 0.078 13.3 0.0 10.0 10 0 0 10 10 9 3 HEAT repeat HEAT_2 PF13646.6 KOG97638.1 - 1.8e-14 53.9 0.1 2.9e-05 24.4 0.0 7.0 4 2 3 7 7 7 5 HEAT repeats CLASP_N PF12348.8 KOG97638.1 - 9.4e-08 31.9 1.2 0.0014 18.2 0.4 4.0 4 0 0 4 4 4 2 CLASP N terminal RIX1 PF08167.12 KOG97638.1 - 2.7e-07 30.5 4.0 0.0025 17.6 0.2 5.4 5 1 1 6 6 6 1 rRNA processing/ribosome biogenesis Vac14_Fab1_bd PF12755.7 KOG97638.1 - 3.3e-06 27.6 0.7 1.2 9.8 0.0 7.0 5 1 2 8 8 8 1 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 KOG97638.1 - 4.8e-06 26.0 10.6 0.00011 21.4 1.9 3.6 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal IFRD PF05004.13 KOG97638.1 - 0.00026 20.2 3.8 0.17 11.0 0.4 4.4 4 1 1 5 5 5 2 Interferon-related developmental regulator (IFRD) DUF3385 PF11865.8 KOG97638.1 - 0.00035 20.5 10.1 0.18 11.7 0.3 6.7 4 3 0 6 6 6 1 Domain of unknown function (DUF3385) Arm PF00514.23 KOG97638.1 - 0.003 17.5 7.4 5 7.3 0.1 6.1 7 0 0 7 7 6 1 Armadillo/beta-catenin-like repeat ParcG PF10274.9 KOG97638.1 - 0.0054 16.9 0.4 0.45 10.6 0.0 3.3 3 1 0 3 3 2 1 Parkin co-regulated protein DNA_alkylation PF08713.11 KOG97638.1 - 0.012 15.4 0.0 0.045 13.5 0.0 2.1 1 0 0 1 1 1 0 DNA alkylation repair enzyme Xpo1 PF08389.12 KOG97638.1 - 0.2 11.7 9.9 0.48 10.5 0.0 5.5 5 2 1 6 6 6 0 Exportin 1-like protein RTP1_C1 PF10363.9 KOG97638.1 - 0.33 11.1 2.9 29 4.9 0.1 4.9 6 0 0 6 6 5 0 Required for nuclear transport of RNA pol II C-terminus 1 eIF-3c_N PF05470.12 KOG97639.1 - 2.1e-198 660.4 28.3 5.2e-155 517.1 9.3 2.6 2 1 1 3 3 3 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 KOG97639.1 - 1.5e-12 48.0 0.3 1.5e-12 48.0 0.3 3.4 3 2 0 3 3 3 1 PCI domain Fumerase PF05681.14 KOG97639.1 - 0.19 11.1 0.1 0.35 10.3 0.1 1.4 1 0 0 1 1 1 0 Fumarate hydratase (Fumerase) GPS2_interact PF15784.5 KOG97639.1 - 3 8.4 10.4 2.8 8.5 0.7 3.7 3 0 0 3 3 3 0 G-protein pathway suppressor 2-interacting domain Methyltrn_RNA_3 PF02598.17 KOG97640.1 - 2e-64 217.9 0.0 2.2e-64 217.7 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase IPP-2 PF04979.14 KOG97641.1 - 1.3e-22 81.0 14.1 1.3e-22 81.0 14.1 2.1 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) DUF3135 PF11333.8 KOG97641.1 - 0.0057 16.9 1.8 0.0089 16.3 0.0 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF3135) Flavi_NS2B PF01002.19 KOG97641.1 - 0.24 11.2 0.1 0.54 10.1 0.1 1.6 1 0 0 1 1 1 0 Flavivirus non-structural protein NS2B PEHE PF15275.6 KOG97641.1 - 6 7.5 11.1 0.46 11.1 4.2 2.2 2 1 0 2 2 2 0 PEHE domain ELP6 PF09807.9 KOG97642.1 - 3.7e-05 23.3 0.2 0.00022 20.7 0.1 2.0 1 1 1 2 2 2 1 Elongation complex protein 6 RasGEF_N PF00618.20 KOG97642.1 - 0.039 14.2 2.6 0.049 13.9 1.4 1.8 1 1 1 2 2 2 0 RasGEF N-terminal motif DUF3336 PF11815.8 KOG97643.1 - 4.8e-26 91.1 0.2 9.2e-26 90.2 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 KOG97643.1 - 2e-07 31.4 0.3 4.2e-07 30.3 0.3 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase YGGT PF02325.17 KOG97643.1 - 8 7.0 6.3 34 4.9 1.6 3.1 3 0 0 3 3 3 0 YGGT family Proteasome PF00227.26 KOG97644.1 - 2e-44 151.4 0.0 2.4e-44 151.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOG97644.1 - 6.3e-12 44.9 0.1 1.3e-11 43.9 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature GFO_IDH_MocA PF01408.22 KOG97645.1 - 1.9e-25 90.0 0.2 1.7e-24 86.9 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 KOG97645.1 - 1.7e-12 47.4 0.0 2.9e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain ADH_N PF08240.12 KOG97649.1 - 2.1e-28 98.4 5.2 3.7e-28 97.6 5.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOG97649.1 - 1.1e-19 70.7 0.0 1.8e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 KOG97649.1 - 5.4e-06 25.9 0.3 1.1e-05 24.9 0.3 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 KOG97649.1 - 8.8e-06 26.8 0.0 1.4e-05 26.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 KOG97649.1 - 0.0092 15.3 0.1 0.022 14.1 0.0 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 KOG97649.1 - 0.082 13.4 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding RseC_MucC PF04246.12 KOG97649.1 - 0.1 12.5 3.7 0.11 12.4 2.3 1.8 1 1 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Iron_permease PF04120.12 KOG97650.1 - 4.2e-27 94.5 22.8 1.5e-13 50.6 0.8 5.2 5 0 0 5 5 5 5 Low affinity iron permease S-methyl_trans PF02574.16 KOG97651.1 - 4.7e-30 105.3 0.0 5.3e-30 105.1 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase AA_permease PF00324.21 KOG97652.1 - 1.5e-98 330.5 36.1 1.6e-98 330.4 36.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG97652.1 - 1.6e-35 122.8 37.4 2e-35 122.5 37.4 1.0 1 0 0 1 1 1 1 Amino acid permease Ycf4 PF02392.16 KOG97652.1 - 0.041 13.4 0.4 0.15 11.6 0.4 2.0 1 0 0 1 1 1 0 Ycf4 AA_permease PF00324.21 KOG97653.1 - 1.8e-94 317.1 38.0 2.2e-94 316.8 38.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG97653.1 - 7.2e-21 74.5 43.4 1.2e-20 73.8 43.4 1.3 1 0 0 1 1 1 1 Amino acid permease SpoVAB PF13782.6 KOG97653.1 - 0.0072 16.6 0.2 0.0072 16.6 0.2 2.7 2 1 0 2 2 2 1 Stage V sporulation protein AB Sugar_tr PF00083.24 KOG97654.1 - 1.9e-45 155.6 8.3 2.2e-45 155.4 8.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG97654.1 - 8.1e-14 51.3 6.3 8.1e-14 51.3 6.3 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 KOG97654.1 - 5.2e-05 21.9 1.5 7.5e-05 21.3 1.5 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 KOG97654.1 - 7.9e-05 21.4 1.4 0.00011 21.0 1.4 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein SNO PF01174.19 KOG97655.1 - 2.3e-12 47.2 0.1 2.5e-12 47.0 0.1 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family Sugar_tr PF00083.24 KOG97656.1 - 5e-128 427.8 21.4 5.7e-128 427.6 21.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG97656.1 - 9.9e-27 93.8 32.5 4.3e-24 85.1 11.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OppC_N PF12911.7 KOG97656.1 - 0.098 12.7 0.3 0.098 12.7 0.3 3.0 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C Flavoprotein PF02441.19 KOG97657.1 - 2.4e-21 76.2 0.2 3.1e-21 75.8 0.2 1.1 1 0 0 1 1 1 1 Flavoprotein UbiD PF01977.16 KOG97658.1 - 3.3e-110 368.7 0.0 3.8e-110 368.6 0.0 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2-Hacid_dh_C PF02826.19 KOG97659.1 - 9.1e-40 135.9 0.0 4.6e-39 133.6 0.0 2.0 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOG97659.1 - 4.8e-19 68.3 0.1 6.6e-19 67.9 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Shikimate_DH PF01488.20 KOG97659.1 - 0.057 13.5 0.2 0.49 10.4 0.0 2.4 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Helicase_C PF00271.31 KOG97662.1 - 9.4e-12 45.3 0.0 1.5e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain THP2 PF09432.10 KOG97662.1 - 0.031 14.3 0.0 0.047 13.8 0.0 1.3 1 0 0 1 1 1 0 Tho complex subunit THP2 DUF5341 PF17276.2 KOG97663.1 - 1.5e-52 178.0 2.1 2.1e-52 177.6 2.1 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5341) DUF3099 PF11298.8 KOG97663.1 - 3.1 8.0 8.2 15 5.8 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3099) Cys_Met_Meta_PP PF01053.20 KOG97664.1 - 8.3e-29 100.3 0.0 1.9e-28 99.1 0.0 1.5 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KOG97664.1 - 0.0022 17.3 0.0 0.0038 16.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Tox-MPTase4 PF15640.6 KOG97664.1 - 0.17 11.8 0.0 6.5 6.7 0.0 2.4 2 0 0 2 2 2 0 Metallopeptidase toxin 4 MFS_1 PF07690.16 KOG97665.1 - 4.2e-18 65.4 48.4 8.5e-18 64.4 43.8 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Zn_clus PF00172.18 KOG97666.1 - 3.2e-08 33.5 17.2 3.2e-08 33.5 17.2 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF761 PF05553.11 KOG97666.1 - 0.16 11.5 0.1 0.36 10.4 0.1 1.6 1 0 0 1 1 1 0 Cotton fibre expressed protein MFS_1 PF07690.16 KOG97667.1 - 7.8e-38 130.3 58.0 6.9e-35 120.6 40.2 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Glycophorin_A PF01102.18 KOG97667.1 - 0.16 12.3 0.2 8.4 6.7 0.1 2.5 2 0 0 2 2 2 0 Glycophorin A ACT PF01842.25 KOG97667.1 - 0.17 11.7 0.2 0.52 10.1 0.1 1.8 2 0 0 2 2 2 0 ACT domain DUF3040 PF11239.8 KOG97667.1 - 0.35 11.2 0.0 0.35 11.2 0.0 4.9 5 1 1 6 6 6 0 Protein of unknown function (DUF3040) SirB PF04247.12 KOG97667.1 - 3.8 7.6 11.2 12 6.0 0.2 3.3 2 1 1 3 3 3 0 Invasion gene expression up-regulator, SirB TauD PF02668.16 KOG97668.1 - 2.9e-54 184.7 1.0 3.7e-54 184.3 1.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Epimerase PF01370.21 KOG97669.1 - 1.1e-13 51.2 0.1 4.9e-13 49.1 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOG97669.1 - 6e-09 35.3 0.2 1e-07 31.3 0.2 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 KOG97669.1 - 4.6e-08 33.2 0.0 7.5e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 KOG97669.1 - 3.6e-07 29.9 0.2 3.6e-06 26.6 0.1 2.4 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 KOG97669.1 - 1.8e-05 24.4 0.1 2.9e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 KOG97669.1 - 5.2e-05 22.8 0.2 0.00012 21.6 0.2 1.7 2 0 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 KOG97669.1 - 0.00012 21.2 0.0 0.00044 19.4 0.0 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 KOG97669.1 - 0.021 14.0 0.1 0.053 12.7 0.1 1.7 1 1 1 2 2 2 0 Male sterility protein DapB_N PF01113.20 KOG97669.1 - 0.2 11.8 0.4 0.79 9.9 0.1 2.1 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Flocculin_t3 PF13928.6 KOG97670.1 - 9e-25 86.9 49.7 5.3e-14 52.5 20.3 7.9 5 2 1 6 6 6 2 Flocculin type 3 repeat EMI PF07546.13 KOG97670.1 - 0.96 10.3 10.2 12 6.8 0.6 2.9 2 0 0 2 2 2 0 EMI domain Antifungal_pept PF11410.8 KOG97670.1 - 3.2 7.7 4.8 25 4.9 0.3 2.3 2 0 0 2 2 2 0 Antifungal peptide Zn_clus PF00172.18 KOG97671.1 - 3.9e-08 33.3 8.6 7e-08 32.5 8.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MIP PF00230.20 KOG97672.1 - 3.5e-43 147.9 14.0 4.4e-43 147.6 14.0 1.1 1 0 0 1 1 1 1 Major intrinsic protein FAD_binding_8 PF08022.12 KOG97673.1 - 3.6e-27 94.6 0.0 8.5e-27 93.4 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 KOG97673.1 - 8.2e-25 87.3 13.0 8.2e-25 87.3 13.0 2.5 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 KOG97673.1 - 3.4e-21 76.0 0.0 6.2e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Cofilin_ADF PF00241.20 KOG97674.1 - 3.4e-08 33.3 0.0 3.6e-08 33.2 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein ABC_membrane PF00664.23 KOG97676.1 - 1.6e-60 205.1 44.6 1.6e-37 129.7 11.3 4.1 4 0 0 4 4 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 KOG97676.1 - 3.8e-56 189.4 0.9 9.1e-34 116.9 0.2 2.6 2 0 0 2 2 2 2 ABC transporter AAA_23 PF13476.6 KOG97676.1 - 1.8e-11 44.9 2.1 3.6e-05 24.3 0.0 3.5 3 0 0 3 3 2 2 AAA domain AAA_21 PF13304.6 KOG97676.1 - 7.4e-10 39.1 3.7 0.0061 16.4 0.2 3.5 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOG97676.1 - 3.4e-09 36.5 8.2 0.00018 21.0 3.2 3.9 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOG97676.1 - 2.4e-07 30.4 0.5 0.0048 16.6 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOG97676.1 - 1.6e-06 28.2 0.0 0.018 15.0 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KOG97676.1 - 3e-06 27.3 0.4 0.0087 16.1 0.0 3.2 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_15 PF13175.6 KOG97676.1 - 1.2e-05 25.2 2.0 0.0008 19.2 0.4 3.7 4 0 0 4 4 4 2 AAA ATPase domain AAA_16 PF13191.6 KOG97676.1 - 2.5e-05 24.7 0.1 0.38 11.1 0.0 3.0 3 0 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.6 KOG97676.1 - 3.5e-05 24.1 0.1 0.69 10.2 0.1 3.2 2 1 0 2 2 2 2 AAA domain DUF87 PF01935.17 KOG97676.1 - 4.3e-05 23.7 1.5 0.26 11.3 0.0 3.1 3 0 0 3 3 3 2 Helicase HerA, central domain ATP_bind_1 PF03029.17 KOG97676.1 - 0.00013 21.8 0.0 2.3 7.9 0.0 3.5 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein T2SSE PF00437.20 KOG97676.1 - 0.00014 21.1 0.0 0.054 12.5 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein Dynamin_N PF00350.23 KOG97676.1 - 0.00051 20.1 0.2 0.18 11.9 0.1 2.9 2 0 0 2 2 2 1 Dynamin family AAA_30 PF13604.6 KOG97676.1 - 0.00078 19.2 0.1 0.98 9.1 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_7 PF12775.7 KOG97676.1 - 0.0014 18.2 0.2 0.53 9.8 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA PF00004.29 KOG97676.1 - 0.0025 18.2 0.3 3.6 8.0 0.0 3.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 KOG97676.1 - 0.0029 16.9 0.0 2.7 7.2 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin FtsK_SpoIIIE PF01580.18 KOG97676.1 - 0.005 16.2 0.1 3.5 6.9 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_10 PF12846.7 KOG97676.1 - 0.0089 15.0 0.3 2.5 6.9 0.0 2.7 3 0 0 3 3 3 1 AAA-like domain AAA_25 PF13481.6 KOG97676.1 - 0.017 14.7 0.0 0.65 9.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 KOG97676.1 - 0.021 14.4 0.0 1.2 8.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 KOG97676.1 - 0.024 13.6 0.1 0.3 10.0 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 KOG97676.1 - 0.04 14.1 0.0 4.5 7.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 KOG97676.1 - 0.042 13.6 0.2 7.1 6.3 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein Roc PF08477.13 KOG97676.1 - 0.044 14.0 0.1 16 5.8 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 KOG97676.1 - 0.045 13.3 2.5 1.5 8.4 0.2 3.0 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 KOG97676.1 - 0.1 12.3 0.1 6.7 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 KOG97676.1 - 0.1 12.0 0.9 1 8.8 0.0 2.7 3 0 0 3 3 3 0 PhoH-like protein TrwB_AAD_bind PF10412.9 KOG97676.1 - 0.13 11.1 0.0 11 4.8 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain RNA_helicase PF00910.22 KOG97676.1 - 0.14 12.5 0.2 41 4.6 0.0 3.2 3 0 0 3 3 3 0 RNA helicase DUF5489 PF17592.2 KOG97676.1 - 3.1 8.4 7.8 0.2 12.2 1.2 2.5 2 0 0 2 2 1 0 Family of unknown function (DUF5489) Ribosomal_L7Ae PF01248.26 KOG97677.1 - 1.4e-22 79.2 0.3 2.2e-22 78.6 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 KOG97677.1 - 0.00074 19.6 0.1 0.0013 18.8 0.1 1.4 1 0 0 1 1 1 1 RNase P subunit Pop3 MIP PF00230.20 KOG97678.1 - 8.9e-85 284.0 8.4 1.2e-84 283.6 8.4 1.1 1 0 0 1 1 1 1 Major intrinsic protein EPL1 PF10513.9 KOG97678.1 - 0.016 15.6 3.2 0.016 15.6 3.2 2.7 3 0 0 3 3 3 0 Enhancer of polycomb-like AGH PF17558.2 KOG97678.1 - 0.056 13.6 0.4 0.12 12.6 0.4 1.4 1 0 0 1 1 1 0 Androgenic gland hormone Autophagy_act_C PF03987.15 KOG97679.1 - 7e-08 32.9 0.2 3e-07 30.9 0.2 2.1 2 1 0 2 2 2 1 Autophagocytosis associated protein, active-site domain AAA_35 PF14516.6 KOG97679.1 - 0.035 13.0 0.1 0.046 12.6 0.1 1.3 1 1 0 1 1 1 0 AAA-like domain Fer2_3 PF13085.6 KOG97680.1 - 1.1e-33 115.4 0.1 1.9e-33 114.7 0.1 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 KOG97680.1 - 5.4e-09 36.5 8.1 5.4e-09 36.5 8.1 2.1 2 1 1 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 KOG97680.1 - 2.9e-08 34.0 7.4 2.9e-08 34.0 7.4 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 KOG97680.1 - 1.6e-07 31.3 4.2 1.6e-07 31.3 4.2 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 KOG97680.1 - 0.0044 16.9 5.0 0.0058 16.5 1.6 2.4 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 KOG97680.1 - 0.0074 16.9 7.4 0.0074 16.9 7.4 2.5 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 KOG97680.1 - 0.015 15.5 8.1 0.015 15.5 8.1 2.5 2 1 0 2 2 2 0 4Fe-4S dicluster domain SHR-BD PF06650.12 KOG97681.1 - 1.2e-90 303.6 6.2 1.2e-90 303.6 6.2 3.2 4 0 0 4 4 4 2 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_mid_rpt PF16910.5 KOG97681.1 - 4.7e-82 275.0 22.9 4.3e-79 265.2 0.2 6.9 5 1 1 7 7 7 3 Repeating coiled region of VPS13 VPS13 PF16908.5 KOG97681.1 - 1.2e-75 254.4 8.1 1.6e-73 247.4 0.5 4.4 4 0 0 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 KOG97681.1 - 5.4e-67 225.0 13.0 4.3e-65 218.8 0.2 3.5 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 KOG97681.1 - 1.7e-38 131.3 0.3 1.1e-37 128.6 0.0 2.7 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 KOG97681.1 - 0.014 15.7 0.0 0.046 14.1 0.0 1.9 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain NTP_transf_6 PF06042.11 KOG97681.1 - 0.016 15.1 0.0 0.054 13.4 0.0 1.9 1 0 0 1 1 1 0 Nucleotidyltransferase ENTH PF01417.20 KOG97682.1 - 1.7e-36 125.0 1.3 2.3e-36 124.6 1.3 1.2 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 KOG97682.1 - 3.8e-05 22.8 0.2 5.5e-05 22.3 0.2 1.3 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 KOG97682.1 - 0.02 14.7 0.1 0.034 14.0 0.1 1.4 1 0 0 1 1 1 0 VHS domain Prp19 PF08606.11 KOG97683.1 - 8.4e-25 86.6 0.3 1.7e-24 85.6 0.3 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like U-box PF04564.15 KOG97683.1 - 0.00026 21.1 0.0 0.00071 19.7 0.0 1.8 1 0 0 1 1 1 1 U-box domain ANAPC4_WD40 PF12894.7 KOG97683.1 - 0.0011 19.2 0.0 0.23 11.8 0.0 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain GIT_CC PF16559.5 KOG97683.1 - 0.01 15.7 0.0 0.026 14.4 0.0 1.7 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor CLP1_P PF16575.5 KOG97684.1 - 1.8e-29 102.9 0.0 2.7e-29 102.3 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 KOG97684.1 - 0.015 15.4 0.0 0.035 14.2 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.20 KOG97684.1 - 0.043 13.0 0.0 0.082 12.0 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 KOG97684.1 - 0.046 13.1 0.0 0.076 12.4 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family VirE PF05272.11 KOG97684.1 - 0.053 13.3 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Virulence-associated protein E Imm5 PF14423.6 KOG97684.1 - 0.23 11.7 1.8 0.44 10.7 1.8 1.4 1 0 0 1 1 1 0 Immunity protein Imm5 AAA PF00004.29 KOG97685.1 - 2.1e-94 312.9 0.0 2.1e-47 160.8 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG97685.1 - 4.1e-25 87.3 0.2 1.9e-11 43.6 0.1 2.9 2 1 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 KOG97685.1 - 5.9e-15 55.4 0.0 1.2e-07 31.7 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOG97685.1 - 5.5e-14 52.9 0.4 2.9e-05 24.5 0.0 4.0 2 2 0 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 KOG97685.1 - 3.2e-11 43.7 0.0 0.00026 21.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 KOG97685.1 - 4e-10 40.0 0.0 0.00029 21.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 KOG97685.1 - 6.7e-10 39.4 0.9 0.015 15.6 0.0 4.8 2 2 2 4 4 4 2 AAA domain AAA_5 PF07728.14 KOG97685.1 - 1.2e-09 38.3 0.7 0.0013 18.8 0.0 3.8 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) Vps4_C PF09336.10 KOG97685.1 - 1.6e-08 34.4 0.1 0.00022 21.2 0.0 2.8 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain TIP49 PF06068.13 KOG97685.1 - 1.8e-08 34.0 0.0 0.00039 19.7 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 KOG97685.1 - 3.4e-08 34.1 0.0 0.0013 19.3 0.0 3.2 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 KOG97685.1 - 1.5e-07 31.8 0.0 0.018 15.4 0.0 3.2 3 0 0 3 3 2 2 RNA helicase AAA_14 PF13173.6 KOG97685.1 - 1.8e-07 31.2 0.0 0.022 14.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 KOG97685.1 - 3.3e-07 30.9 0.1 0.019 15.5 0.0 3.2 3 0 0 3 3 2 2 ABC transporter Mg_chelatase PF01078.21 KOG97685.1 - 2.8e-06 26.9 0.4 0.031 13.6 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 KOG97685.1 - 4.4e-06 26.7 0.0 0.026 14.4 0.0 2.9 3 0 0 3 3 2 2 Rad17 P-loop domain Zeta_toxin PF06414.12 KOG97685.1 - 4.8e-06 26.0 0.0 0.11 11.8 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_28 PF13521.6 KOG97685.1 - 6.4e-06 26.5 0.0 0.079 13.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 KOG97685.1 - 7e-06 25.9 0.1 0.094 12.4 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_3 PF07726.11 KOG97685.1 - 1.9e-05 24.5 0.0 0.11 12.4 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Cytidylate_kin2 PF13189.6 KOG97685.1 - 2.8e-05 24.3 0.0 0.0017 18.5 0.0 2.8 3 0 0 3 3 2 1 Cytidylate kinase-like family NACHT PF05729.12 KOG97685.1 - 8.1e-05 22.6 0.1 0.49 10.3 0.0 2.9 3 0 0 3 3 2 2 NACHT domain AAA_7 PF12775.7 KOG97685.1 - 9.8e-05 21.9 0.0 0.24 10.9 0.0 2.9 3 0 0 3 3 2 2 P-loop containing dynein motor region TsaE PF02367.17 KOG97685.1 - 0.00012 22.1 0.0 0.75 9.8 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 KOG97685.1 - 0.00014 22.3 3.1 0.14 12.5 0.0 3.8 4 0 0 4 4 3 1 AAA domain AAA_25 PF13481.6 KOG97685.1 - 0.00017 21.2 0.1 1.3 8.5 0.0 3.8 4 1 0 4 4 4 1 AAA domain SKI PF01202.22 KOG97685.1 - 0.00017 21.7 0.0 0.24 11.5 0.0 2.8 2 0 0 2 2 2 1 Shikimate kinase Viral_helicase1 PF01443.18 KOG97685.1 - 0.00022 21.0 0.0 0.62 9.8 0.0 2.5 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 KOG97685.1 - 0.00024 21.0 2.6 0.63 9.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain DUF815 PF05673.13 KOG97685.1 - 0.00066 18.9 0.0 0.25 10.5 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 KOG97685.1 - 0.00091 19.0 0.0 1.4 8.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 KOG97685.1 - 0.001 18.8 0.0 0.84 9.3 0.0 2.9 3 0 0 3 3 3 1 Sigma-54 interaction domain ATPase_2 PF01637.18 KOG97685.1 - 0.0015 18.5 0.0 2.8 7.8 0.0 3.2 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea NB-ARC PF00931.22 KOG97685.1 - 0.0015 17.7 0.1 1.1 8.4 0.0 2.8 2 0 0 2 2 2 1 NB-ARC domain CPT PF07931.12 KOG97685.1 - 0.0017 18.2 0.0 0.036 13.9 0.0 2.3 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein Parvo_NS1 PF01057.17 KOG97685.1 - 0.0022 17.1 0.0 1.7 7.7 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 SRPRB PF09439.10 KOG97685.1 - 0.0031 17.0 0.0 1.1 8.7 0.0 3.1 3 0 0 3 3 2 1 Signal recognition particle receptor beta subunit ATPase PF06745.13 KOG97685.1 - 0.0033 16.8 0.1 3.4 7.0 0.0 3.2 3 0 0 3 3 3 1 KaiC Sigma54_activ_2 PF14532.6 KOG97685.1 - 0.0035 17.5 0.0 3.7 7.7 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Cytidylate_kin PF02224.18 KOG97685.1 - 0.012 15.4 0.1 1 9.1 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase PduV-EutP PF10662.9 KOG97685.1 - 0.018 14.8 0.0 7.9 6.2 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PhoH PF02562.16 KOG97685.1 - 0.023 14.2 0.1 3.2 7.2 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.6 KOG97685.1 - 0.033 14.5 0.1 9.7 6.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 KOG97685.1 - 0.042 13.7 0.0 12 5.7 0.0 2.5 2 0 0 2 2 2 0 NTPase Hydin_ADK PF17213.3 KOG97685.1 - 0.049 13.9 3.4 0.93 9.7 0.0 3.7 4 0 0 4 4 4 0 Hydin Adenylate kinase-like domain AFG1_ATPase PF03969.16 KOG97685.1 - 0.053 12.4 0.0 9.9 4.9 0.0 2.5 2 0 0 2 2 2 0 AFG1-like ATPase RsgA_GTPase PF03193.16 KOG97685.1 - 0.07 13.0 0.0 1 9.2 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 KOG97685.1 - 0.093 12.8 0.4 3 8.0 0.1 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase FeoB_N PF02421.18 KOG97685.1 - 0.097 12.2 0.1 2.8 7.4 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_29 PF13555.6 KOG97685.1 - 0.15 11.8 0.0 13 5.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain ADK PF00406.22 KOG97685.1 - 0.16 12.1 0.6 26 4.9 0.1 3.2 3 0 0 3 3 3 0 Adenylate kinase AAA_23 PF13476.6 KOG97685.1 - 1.2 9.6 0.0 1.2 9.6 0.0 4.1 4 0 0 4 4 2 0 AAA domain KH_1 PF00013.29 KOG97687.1 - 1.3e-09 37.7 1.1 0.0055 16.5 0.0 3.9 4 0 0 4 4 4 3 KH domain Phosphodiest PF01663.22 KOG97688.1 - 1.4e-13 51.2 0.8 2.6e-13 50.3 0.8 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 KOG97688.1 - 0.0078 15.6 1.2 0.0078 15.6 1.2 1.5 2 0 0 2 2 2 1 Metalloenzyme superfamily Creatinase_N_2 PF16189.5 KOG97689.1 - 3.9e-43 147.3 0.2 4.1e-42 144.0 0.1 2.3 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 KOG97689.1 - 3e-39 134.9 0.0 1.6e-38 132.5 0.0 2.0 2 0 0 2 2 2 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 KOG97689.1 - 1.7e-21 76.0 1.2 8.5e-21 73.8 0.6 2.5 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 KOG97689.1 - 3.1e-10 40.8 0.0 3e-09 37.6 0.0 2.2 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain MFS_1 PF07690.16 KOG97690.1 - 1.9e-40 138.9 31.5 1.9e-40 138.9 31.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG97690.1 - 2.9e-07 29.7 26.0 2.9e-07 29.7 26.0 3.0 1 1 1 2 2 2 2 Sugar (and other) transporter Fe-S_biosyn PF01521.20 KOG97691.1 - 5.8e-19 68.3 0.0 1.1e-18 67.4 0.0 1.5 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF3853 PF12964.7 KOG97691.1 - 0.037 14.2 0.0 0.15 12.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3853) AAA_2 PF07724.14 KOG97692.1 - 4.3e-47 160.4 0.0 3.6e-45 154.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 KOG97692.1 - 1.1e-27 96.0 0.4 1.1e-27 96.0 0.4 3.1 1 1 1 2 2 2 1 AAA lid domain AAA PF00004.29 KOG97692.1 - 6.7e-24 84.8 0.2 2.3e-14 53.9 0.1 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 KOG97692.1 - 8.9e-24 83.4 1.3 3.4e-23 81.5 1.3 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 KOG97692.1 - 6.2e-15 55.4 0.0 3.1e-07 30.5 0.0 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 KOG97692.1 - 1.4e-14 53.9 5.8 1.2e-09 38.1 0.7 3.5 3 0 0 3 3 3 2 Clp amino terminal domain, pathogenicity island component Sigma54_activat PF00158.26 KOG97692.1 - 1.2e-12 47.8 0.2 2.7e-08 33.7 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 KOG97692.1 - 2.8e-08 34.4 8.3 4.8e-05 23.8 0.0 4.8 5 1 0 5 5 4 2 AAA ATPase domain AAA_22 PF13401.6 KOG97692.1 - 1.5e-06 28.5 0.3 0.049 13.9 0.1 4.0 2 2 0 2 2 2 2 AAA domain AAA_14 PF13173.6 KOG97692.1 - 3.1e-06 27.2 0.3 0.021 14.9 0.0 3.0 3 0 0 3 3 2 2 AAA domain TniB PF05621.11 KOG97692.1 - 4e-06 26.4 0.1 0.002 17.6 0.1 4.0 2 1 1 3 3 3 1 Bacterial TniB protein AAA_24 PF13479.6 KOG97692.1 - 0.00015 21.6 0.0 0.13 12.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 KOG97692.1 - 0.00018 21.1 0.0 0.056 12.9 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region TIP49 PF06068.13 KOG97692.1 - 0.00036 19.8 4.9 0.51 9.5 0.0 3.9 4 0 0 4 4 4 2 TIP49 P-loop domain Mg_chelatase PF01078.21 KOG97692.1 - 0.00053 19.4 0.0 2.1 7.7 0.0 3.5 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KOG97692.1 - 0.0021 18.2 0.1 0.23 11.6 0.0 3.1 3 0 0 3 3 2 1 AAA domain AAA_3 PF07726.11 KOG97692.1 - 0.0028 17.5 0.1 1 9.2 0.0 3.2 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 KOG97692.1 - 0.0031 16.8 0.6 0.42 9.9 0.0 3.5 3 1 0 3 3 3 1 Zeta toxin NACHT PF05729.12 KOG97692.1 - 0.0032 17.4 0.0 1.2 9.0 0.0 2.8 2 0 0 2 2 2 1 NACHT domain Torsin PF06309.11 KOG97692.1 - 0.0043 17.2 0.0 0.017 15.2 0.0 2.0 2 0 0 2 2 1 1 Torsin ATPase_2 PF01637.18 KOG97692.1 - 0.0083 16.1 6.2 2.4 8.0 0.1 4.3 3 1 1 4 4 4 1 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 KOG97692.1 - 0.0085 15.8 0.0 0.51 10.0 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_19 PF13245.6 KOG97692.1 - 0.025 14.9 0.1 0.83 10.0 0.2 3.1 2 1 0 2 2 2 0 AAA domain PEPCK_ATP PF01293.20 KOG97692.1 - 0.029 13.0 0.0 0.069 11.8 0.0 1.5 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase TsaE PF02367.17 KOG97692.1 - 0.03 14.3 0.0 1.4 8.9 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 KOG97692.1 - 0.046 14.0 0.0 13 6.0 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 KOG97692.1 - 0.061 13.2 0.0 5.4 6.9 0.0 3.1 3 0 0 3 3 2 0 NTPase Viral_helicase1 PF01443.18 KOG97692.1 - 0.089 12.5 0.0 11 5.7 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AcylCoA_dehyd_C PF12186.8 KOG97692.1 - 0.19 11.9 5.1 9.9 6.3 0.1 2.6 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase C terminal ABC_tran PF00005.27 KOG97692.1 - 5.6 7.5 8.5 7 7.2 0.2 4.0 4 1 0 4 4 3 0 ABC transporter SRP1_TIP1 PF00660.17 KOG97693.1 - 3e-28 97.8 0.0 4.1e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 Seripauperin and TIP1 family HSP70 PF00012.20 KOG97694.1 - 9.3e-264 876.2 8.0 1.1e-263 876.0 8.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOG97694.1 - 1.6e-17 63.4 0.0 1.6e-16 60.1 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 KOG97694.1 - 0.0014 18.4 0.0 0.0048 16.6 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 KOG97694.1 - 0.0068 15.4 0.3 0.1 11.5 0.1 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain FtsA PF14450.6 KOG97694.1 - 0.016 15.6 1.3 20 5.7 0.0 3.6 3 1 0 3 3 3 0 Cell division protein FtsA PilM_2 PF11104.8 KOG97694.1 - 0.02 13.9 0.0 1.5 7.7 0.0 2.3 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; BcrAD_BadFG PF01869.20 KOG97694.1 - 0.04 13.4 0.1 5.5 6.4 0.0 2.6 3 0 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.18 KOG97694.1 - 0.079 12.2 0.1 0.22 10.7 0.1 1.8 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase DUF1542 PF07564.11 KOG97694.1 - 1.2 9.3 8.7 0.073 13.2 2.9 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) MutS_III PF05192.18 KOG97694.1 - 2.9 8.1 7.5 6.1 7.0 1.7 2.4 2 1 0 2 2 2 0 MutS domain III UPF0121 PF03661.13 KOG97695.1 - 2.2e-25 89.5 15.9 4.6e-25 88.4 15.9 1.5 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0121) Hum_adeno_E3A PF05393.11 KOG97695.1 - 0.0011 18.9 1.0 0.014 15.4 0.4 2.3 2 0 0 2 2 2 1 Human adenovirus early E3A glycoprotein CTP_transf_1 PF01148.20 KOG97695.1 - 3.3 7.4 14.7 1.7 8.3 6.1 2.1 1 1 1 2 2 2 0 Cytidylyltransferase family TPR_12 PF13424.6 KOG97696.1 - 0.00013 22.2 6.1 0.028 14.7 0.0 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOG97696.1 - 0.0016 18.4 10.0 1.5 9.2 0.2 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOG97696.1 - 0.0053 17.5 5.6 42 5.3 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 KOG97696.1 - 0.0065 16.5 2.9 3.8 7.7 0.1 3.7 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_1 PF00515.28 KOG97696.1 - 0.019 14.8 7.5 1.4 8.8 0.0 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat Sec31 PF11549.8 KOG97696.1 - 0.039 13.9 0.0 0.079 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein transport protein SEC31 DUF2397 PF09660.10 KOG97696.1 - 0.042 12.8 0.0 6.2 5.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2397) TPR_16 PF13432.6 KOG97696.1 - 0.24 12.1 6.6 5.3 7.8 0.3 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOG97696.1 - 0.7 10.3 5.8 4.4 7.8 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat SDA1 PF05285.12 KOG97696.1 - 3 7.2 11.0 0.23 10.9 6.6 1.4 2 0 0 2 2 2 0 SDA1 TPR_19 PF14559.6 KOG97696.1 - 3.6 8.2 11.3 1.8 9.2 0.1 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.25 KOG97697.1 - 4e-40 137.9 0.0 5.1e-39 134.2 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97697.1 - 8.2e-17 61.3 0.0 1.6e-16 60.3 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOG97697.1 - 0.0022 16.8 0.2 0.004 16.0 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 KOG97697.1 - 0.064 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CHCH PF06747.13 KOG97698.1 - 0.00024 21.1 12.7 0.0016 18.5 5.4 1.8 1 1 1 2 2 2 2 CHCH domain Pet191_N PF10203.9 KOG97698.1 - 0.044 14.1 3.7 0.069 13.5 3.7 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 KOG97698.1 - 0.46 10.5 5.7 0.74 9.9 5.4 1.5 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, COX17 PF05051.13 KOG97698.1 - 1.2 9.6 5.0 2.5 8.5 1.2 2.1 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) tRNA-synt_2 PF00152.20 KOG97699.1 - 2e-75 253.8 0.2 2.8e-75 253.3 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOG97699.1 - 8.4e-07 28.9 0.1 1.7e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KOG97699.1 - 0.026 14.0 0.4 2.5 7.5 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) NARP1 PF12569.8 KOG97699.1 - 1.2 8.0 8.4 1.7 7.5 8.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RasGEF PF00617.19 KOG97700.1 - 2.6e-55 187.4 0.9 2.6e-55 187.4 0.9 3.0 3 0 0 3 3 3 1 RasGEF domain RasGEF_N PF00618.20 KOG97700.1 - 5.3e-17 62.0 0.3 5.3e-17 62.0 0.3 4.5 5 1 0 5 5 5 1 RasGEF N-terminal motif SH3_1 PF00018.28 KOG97700.1 - 2.9e-05 23.6 0.0 8.9e-05 22.0 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOG97700.1 - 8.3e-05 22.4 0.1 0.0002 21.1 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain Inhibitor_I29 PF08246.12 KOG97700.1 - 0.039 14.4 3.4 0.14 12.6 2.5 2.7 2 1 0 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) ABC_membrane PF00664.23 KOG97701.1 - 2.9e-69 233.8 39.9 1.5e-34 119.9 9.5 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOG97701.1 - 2.1e-49 167.6 0.0 2.2e-29 102.7 0.1 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOG97701.1 - 1.1e-08 34.8 9.8 0.0031 17.0 3.1 3.9 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 KOG97701.1 - 8.3e-07 29.1 0.4 0.05 13.7 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 KOG97701.1 - 8.8e-06 25.4 0.0 0.2 11.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 KOG97701.1 - 6.3e-05 22.9 4.2 0.61 9.8 0.0 4.5 3 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KOG97701.1 - 7.8e-05 22.6 0.6 0.46 10.4 0.0 3.4 3 0 0 3 3 3 1 RsgA GTPase AAA_22 PF13401.6 KOG97701.1 - 0.00042 20.6 1.2 0.61 10.4 0.0 3.6 3 1 0 3 3 2 1 AAA domain AAA_33 PF13671.6 KOG97701.1 - 0.00075 19.7 0.3 1.8 8.7 0.2 3.5 3 0 0 3 3 3 1 AAA domain DUF87 PF01935.17 KOG97701.1 - 0.00086 19.5 0.5 0.13 12.3 0.0 2.8 2 0 0 2 2 2 1 Helicase HerA, central domain TsaE PF02367.17 KOG97701.1 - 0.0061 16.6 0.0 0.25 11.4 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Dynamin_N PF00350.23 KOG97701.1 - 0.0088 16.1 7.0 0.027 14.5 0.1 3.4 3 0 0 3 3 3 1 Dynamin family NB-ARC PF00931.22 KOG97701.1 - 0.017 14.3 1.1 11 5.1 0.0 3.5 4 0 0 4 4 4 0 NB-ARC domain AAA_30 PF13604.6 KOG97701.1 - 0.02 14.6 0.5 1.6 8.4 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 KOG97701.1 - 0.024 15.0 0.1 7.7 6.9 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain MeaB PF03308.16 KOG97701.1 - 0.028 13.4 0.0 3.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB T2SSE PF00437.20 KOG97701.1 - 0.028 13.5 0.0 7.2 5.6 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF1772 PF08592.11 KOG97701.1 - 0.042 14.2 3.1 5.3 7.4 0.1 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF1772) Zeta_toxin PF06414.12 KOG97701.1 - 0.043 13.1 0.0 8.7 5.6 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 KOG97701.1 - 0.06 13.8 9.0 3.5 8.1 0.1 3.3 2 2 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 KOG97701.1 - 0.12 12.1 0.2 28 4.4 0.0 3.0 3 0 0 3 3 2 0 IstB-like ATP binding protein NACHT PF05729.12 KOG97701.1 - 0.13 12.2 0.2 2.2 8.2 0.0 2.8 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.6 KOG97701.1 - 0.13 12.8 0.9 19 5.8 0.2 3.0 2 1 0 2 2 2 0 AAA domain DEAD PF00270.29 KOG97701.1 - 0.22 11.3 1.1 3.6 7.3 1.1 2.9 2 1 0 2 2 2 0 DEAD/DEAH box helicase cobW PF02492.19 KOG97701.1 - 0.31 10.6 2.5 5.4 6.6 0.1 2.8 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 KOG97701.1 - 0.4 10.4 1.9 16 5.1 0.6 2.6 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 KOG97701.1 - 1.7 9.1 4.2 40 4.6 0.3 4.4 4 1 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 KOG97701.1 - 4 7.1 10.4 0.75 9.4 0.1 3.6 4 1 0 4 4 4 0 AAA ATPase domain Rab5ip PF07019.12 KOG97702.1 - 7.5e-19 68.1 5.3 8.8e-19 67.9 5.3 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) PUF PF00806.19 KOG97703.1 - 4.3e-58 189.9 16.9 4.2e-07 29.3 0.0 8.7 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 KOG97703.1 - 0.047 14.0 16.5 0.19 12.1 0.8 4.8 3 1 2 5 5 5 0 CPL (NUC119) domain Abhydro_lipase PF04083.16 KOG97704.1 - 1.3e-16 59.9 0.0 2.3e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 KOG97704.1 - 8.1e-06 25.7 0.0 1.4e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOG97704.1 - 0.055 12.7 0.0 0.24 10.6 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Preseq_ALAS PF09029.10 KOG97704.1 - 0.058 13.9 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 5-aminolevulinate synthase presequence Tetraspanin PF00335.20 KOG97704.1 - 0.084 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Tetraspanin family Sof1 PF04158.14 KOG97705.1 - 6.2e-28 96.9 14.4 6.2e-28 96.9 14.4 2.4 2 0 0 2 2 2 1 Sof1-like domain WD40 PF00400.32 KOG97705.1 - 6.9e-26 90.0 9.7 3e-06 27.8 0.0 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97705.1 - 2.5e-06 27.7 0.6 0.14 12.4 0.0 4.4 3 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOG97705.1 - 7.2e-05 21.9 1.5 0.051 12.5 0.1 3.2 2 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 KOG97705.1 - 0.003 17.6 0.4 0.35 10.9 0.0 3.6 4 1 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region NIF PF03031.18 KOG97706.1 - 6.7e-52 175.4 0.2 1.3e-51 174.4 0.2 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 KOG97706.1 - 0.024 15.0 0.0 0.042 14.3 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase CDC27 PF09507.10 KOG97706.1 - 0.11 11.9 30.0 0.15 11.4 30.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 NST1 PF13945.6 KOG97706.1 - 0.46 10.6 23.5 0.13 12.3 20.2 1.7 1 1 1 2 2 2 0 Salt tolerance down-regulator Utp14 PF04615.13 KOG97706.1 - 1.5 7.3 29.1 2.2 6.8 29.1 1.1 1 0 0 1 1 1 0 Utp14 protein Ndc1_Nup PF09531.10 KOG97706.1 - 8.6 4.9 9.1 11 4.5 9.1 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup COX17 PF05051.13 KOG97707.1 - 3.6e-22 78.5 8.6 3.6e-22 78.5 8.6 2.2 2 1 0 2 2 2 1 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 KOG97707.1 - 0.00021 21.3 4.0 0.00021 21.3 4.0 2.8 2 1 0 2 2 2 1 CHCH domain DEAD PF00270.29 KOG97708.1 - 1.5e-44 151.9 0.0 3e-44 150.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG97708.1 - 9.6e-28 96.8 0.0 7.8e-27 93.8 0.0 2.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Rota_NS35 PF02509.14 KOG97708.1 - 0.12 11.3 1.1 2.5 7.0 0.1 2.2 2 0 0 2 2 2 0 Rotavirus non-structural protein 35 PH_12 PF16457.5 KOG97709.1 - 2.2e-08 34.7 0.0 4.1e-07 30.6 0.0 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain MMM1 PF10296.9 KOG97710.1 - 5.3e-140 466.2 0.1 6.4e-140 465.9 0.1 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 RSN1_7TM PF02714.15 KOG97711.1 - 1.1e-72 244.7 29.4 1.1e-72 244.7 29.4 2.3 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 KOG97711.1 - 3.6e-22 78.8 7.5 3.6e-22 78.8 7.5 3.4 3 2 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 KOG97711.1 - 0.004 17.4 0.2 0.011 15.9 0.2 1.8 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 KOG97711.1 - 0.0077 16.4 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter HMw1_D2 PF18254.1 KOG97711.1 - 0.073 13.4 0.1 0.67 10.3 0.1 2.3 2 0 0 2 2 2 0 HMW1 domain 2 ORC_WH_C PF18137.1 KOG97712.1 - 1.2e-17 64.3 0.0 4.5e-17 62.4 0.0 2.0 1 1 0 1 1 1 1 Origin recognition complex winged helix C-terminal ORC3_N PF07034.11 KOG97712.1 - 0.00017 20.8 4.2 0.0017 17.6 0.4 2.8 3 0 0 3 3 3 2 Origin recognition complex (ORC) subunit 3 N-terminus Sfi1 PF08457.10 KOG97713.1 - 6.8e-120 401.3 64.7 5.2e-118 395.1 57.1 3.0 1 1 1 2 2 2 2 Sfi1 spindle body protein Sfi1_C PF10638.9 KOG97713.1 - 2.7e-38 130.9 4.0 1.2e-37 128.9 4.0 2.2 1 0 0 1 1 1 1 Spindle body associated protein C-terminus CtsR_C PF17727.1 KOG97713.1 - 0.0031 17.6 0.0 0.034 14.3 0.0 2.6 2 0 0 2 2 2 1 CtsR C-terminal dimerization domain TFIIS_C PF01096.18 KOG97713.1 - 0.049 13.5 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS) HAT_KAT11 PF08214.11 KOG97714.1 - 1.2e-107 360.3 0.3 1.5e-107 360.0 0.3 1.0 1 0 0 1 1 1 1 Histone acetylation protein HycA_repressor PF11046.8 KOG97714.1 - 0.033 14.4 0.1 0.3 11.3 0.0 2.2 2 0 0 2 2 2 0 Transcriptional repressor of hyc and hyp operons Dynamin_M PF01031.20 KOG97715.1 - 2.9e-109 364.7 0.0 5.2e-109 363.9 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 KOG97715.1 - 1.9e-55 187.5 0.0 5.3e-55 186.0 0.0 1.8 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 KOG97715.1 - 1.7e-28 98.6 1.8 4.4e-28 97.3 1.8 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 KOG97715.1 - 0.00011 22.2 0.9 0.00057 20.0 0.2 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase Fasciclin PF02469.22 KOG97716.1 - 5.4e-19 68.7 4.4 2.1e-07 31.2 0.1 5.3 5 1 0 5 5 5 4 Fasciclin domain CMS1 PF14617.6 KOG97717.1 - 2.4e-15 56.6 12.5 1.9e-14 53.7 12.5 2.2 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Jak1_Phl PF17887.1 KOG97717.1 - 0.035 14.1 2.9 0.071 13.1 2.9 1.5 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain MFS_1 PF07690.16 KOG97718.1 - 1.1e-35 123.2 23.4 1.5e-35 122.7 23.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Holin_BhlA PF10960.8 KOG97718.1 - 0.13 12.3 0.2 0.38 10.8 0.2 1.8 1 0 0 1 1 1 0 BhlA holin family Ssl1 PF04056.14 KOG97719.1 - 6.5e-90 300.1 0.1 8.7e-90 299.7 0.1 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 KOG97719.1 - 4.7e-24 84.4 11.0 4.7e-24 84.4 11.0 2.7 2 0 0 2 2 1 1 TFIIH C1-like domain VWA_2 PF13519.6 KOG97719.1 - 1e-13 51.8 0.0 2.4e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain Zn-ribbon_8 PF09723.10 KOG97719.1 - 0.024 14.8 6.1 0.024 14.8 6.1 3.9 4 1 0 4 4 4 0 Zinc ribbon domain DUF2967 PF11179.8 KOG97719.1 - 0.14 10.2 10.8 0.2 9.8 10.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) zf-HIT PF04438.16 KOG97719.1 - 0.39 10.6 18.8 0.76 9.7 6.8 3.2 3 0 0 3 3 3 0 HIT zinc finger DZR PF12773.7 KOG97719.1 - 0.59 10.2 22.4 0.85 9.7 7.4 3.2 2 1 0 2 2 2 0 Double zinc ribbon DUF4683 PF15735.5 KOG97719.1 - 2.1 7.9 8.7 9.3 5.7 8.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4683) eIF-3_zeta PF05091.12 KOG97719.1 - 4.7 6.1 9.9 6.6 5.6 9.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CDC45 PF02724.14 KOG97719.1 - 5.6 5.1 8.0 7.5 4.7 8.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Spt20 PF12090.8 KOG97719.1 - 6.9 6.2 9.5 15 5.1 9.5 1.5 1 0 0 1 1 1 0 Spt20 family IBR PF01485.21 KOG97719.1 - 8.2 6.7 23.4 0.17 12.1 11.2 3.0 1 1 1 2 2 1 0 IBR domain, a half RING-finger domain Response_reg PF00072.24 KOG97720.1 - 1.8e-19 69.9 0.0 2.7e-13 50.1 0.0 2.3 1 1 1 2 2 2 2 Response regulator receiver domain SMC_Nse1 PF07574.13 KOG97721.1 - 6.5e-52 176.3 0.1 8.2e-52 175.9 0.1 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 KOG97721.1 - 1.8e-14 53.7 11.2 3.2e-14 53.0 11.2 1.4 1 0 0 1 1 1 1 RING-like domain DUF1883 PF08980.10 KOG97721.1 - 0.057 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1883) Rpr2 PF04032.16 KOG97721.1 - 2.2 8.6 6.1 24 5.3 6.3 2.2 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DnaJ PF00226.31 KOG97722.1 - 0.00041 20.4 0.0 0.00068 19.7 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 KOG97722.1 - 0.00051 20.0 0.1 0.00066 19.7 0.1 1.2 1 0 0 1 1 1 1 Pam16 Ribosomal_L24e PF01246.20 KOG97723.1 - 8.8e-32 109.2 4.7 8.8e-32 109.2 4.7 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e TFIIF_alpha PF05793.12 KOG97723.1 - 0.035 12.7 15.6 0.045 12.4 15.6 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF3629 PF12302.8 KOG97723.1 - 1.3 8.4 10.1 0.58 9.6 7.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3629) FMN_red PF03358.15 KOG97725.1 - 1.1e-33 116.1 0.0 1.4e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 KOG97725.1 - 7.9e-09 35.5 0.0 1e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold GATA PF00320.27 KOG97727.1 - 1e-14 53.8 0.3 2.1e-14 52.8 0.3 1.5 1 0 0 1 1 1 1 GATA zinc finger zf-NADH-PPase PF09297.11 KOG97727.1 - 0.14 11.8 0.8 1.4 8.6 0.1 2.3 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Fungal_trans PF04082.18 KOG97728.1 - 3.5e-47 160.7 1.4 3.5e-47 160.7 1.4 2.0 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG97728.1 - 4.1e-10 39.6 11.8 7.2e-10 38.8 11.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MPP6 PF10175.9 KOG97728.1 - 0.018 15.5 1.5 0.049 14.1 0.1 2.3 2 0 0 2 2 2 0 M-phase phosphoprotein 6 FHA PF00498.26 KOG97730.1 - 1.6e-13 50.8 0.1 2.8e-13 50.0 0.1 1.4 1 0 0 1 1 1 1 FHA domain PNP_UDP_1 PF01048.20 KOG97731.1 - 3.5e-33 114.8 0.0 4.3e-33 114.5 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily NPCC PF08058.11 KOG97732.1 - 2.1e-36 124.8 0.3 3.3e-36 124.2 0.3 1.3 1 0 0 1 1 1 1 Nuclear pore complex component NIF PF03031.18 KOG97733.1 - 1.5e-54 184.0 0.3 3.1e-54 183.0 0.3 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Abhydro_lipase PF04083.16 KOG97734.1 - 1e-15 57.0 0.0 2e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 KOG97734.1 - 4.7e-05 23.2 1.2 0.00014 21.6 0.2 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOG97734.1 - 0.02 14.1 0.0 0.036 13.3 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 POC3_POC4 PF10448.9 KOG97735.1 - 1.1e-42 145.5 0.0 1.3e-42 145.3 0.0 1.0 1 0 0 1 1 1 1 20S proteasome chaperone assembly proteins 3 and 4 SBDS PF01172.18 KOG97736.1 - 4.1e-33 113.3 2.5 6.3e-33 112.7 2.5 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 KOG97736.1 - 1.7e-28 98.9 4.2 2.3e-28 98.5 0.7 2.1 2 0 0 2 2 2 1 SBDS protein C-terminal domain HlyIII PF03006.20 KOG97737.1 - 9.6e-81 270.8 19.1 1.3e-80 270.4 19.1 1.1 1 0 0 1 1 1 1 Haemolysin-III related zf-UBR PF02207.20 KOG97738.1 - 2.6e-12 46.7 7.6 2.6e-12 46.7 7.6 3.2 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) Snf7 PF03357.21 KOG97739.1 - 2.8e-54 183.3 18.8 2.8e-54 183.3 18.8 1.9 2 0 0 2 2 2 1 Snf7 CHASE3 PF05227.13 KOG97739.1 - 0.013 15.4 3.2 0.013 15.4 3.2 1.9 1 1 0 1 1 1 0 CHASE3 domain DASH_Dad4 PF08650.10 KOG97739.1 - 0.025 14.5 0.5 0.025 14.5 0.5 2.6 3 0 0 3 3 3 0 DASH complex subunit Dad4 DUF4388 PF14332.6 KOG97739.1 - 0.1 12.8 0.1 0.16 12.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4388) Misat_Tub_SegII PF10644.9 KOG97739.1 - 0.21 11.9 0.3 0.21 11.9 0.3 2.2 2 1 0 2 2 2 0 Misato Segment II tubulin-like domain mCpol PF18182.1 KOG97739.1 - 0.44 10.9 4.4 0.58 10.5 0.9 2.4 2 0 0 2 2 2 0 minimal CRISPR polymerase domain Cytochrom_C552 PF02335.15 KOG97739.1 - 3.8 6.3 7.8 2 7.2 5.8 1.4 1 1 0 1 1 1 0 Cytochrome c552 SNARE PF05739.19 KOG97740.1 - 4.3e-14 52.2 0.4 1.4e-13 50.6 0.4 2.0 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.8 KOG97740.1 - 1.3e-06 27.4 0.0 3.2e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin-18_N PF10496.9 KOG97740.1 - 0.00011 22.4 3.1 0.00011 22.4 3.1 2.7 2 1 1 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus Syntaxin PF00804.25 KOG97740.1 - 0.032 13.9 26.4 0.043 13.5 15.9 3.5 1 1 0 2 2 2 0 Syntaxin DUF16 PF01519.16 KOG97740.1 - 0.038 14.5 1.3 0.038 14.5 1.3 3.3 3 1 0 3 3 3 0 Protein of unknown function DUF16 MCPsignal PF00015.21 KOG97740.1 - 1.1 9.0 13.8 0.083 12.7 0.6 3.1 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TBCA PF02970.16 KOG97740.1 - 9.1 6.7 12.4 0.72 10.2 0.8 3.4 3 1 1 4 4 4 0 Tubulin binding cofactor A Aminotran_1_2 PF00155.21 KOG97741.1 - 2.4e-79 267.2 0.1 2.7e-79 267.0 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II TetR_C_28 PF17937.1 KOG97741.1 - 0.13 12.7 0.0 2.3 8.8 0.0 2.6 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain AICARFT_IMPCHas PF01808.18 KOG97743.1 - 6.7e-93 311.4 0.0 1e-92 310.7 0.0 1.3 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 KOG97743.1 - 2.7e-25 88.4 0.4 5.6e-25 87.4 0.0 1.7 2 0 0 2 2 2 1 MGS-like domain DKCLD PF08068.12 KOG97743.1 - 0.13 12.3 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 DKCLD (NUC011) domain Ribosomal_L15e PF00827.17 KOG97744.1 - 6.5e-90 300.0 13.0 8.1e-90 299.7 13.0 1.0 1 0 0 1 1 1 1 Ribosomal L15 SNF2_N PF00176.23 KOG97746.1 - 1.1e-68 231.5 0.1 1.6e-68 231.0 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 KOG97746.1 - 1.4e-17 63.4 0.0 3.1e-17 62.3 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 KOG97746.1 - 8.2e-14 51.9 0.0 3.9e-13 49.7 0.0 2.2 2 0 0 2 2 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 KOG97746.1 - 2.7e-08 33.6 3.3 4.5e-08 32.8 3.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOG97746.1 - 2.9e-08 33.9 6.1 5.8e-08 32.9 6.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KOG97746.1 - 3e-07 30.2 7.5 5.5e-07 29.4 7.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOG97746.1 - 1.1e-06 28.6 5.0 2.1e-06 27.6 5.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOG97746.1 - 1.2e-06 28.4 7.1 2.3e-06 27.5 7.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOG97746.1 - 0.0005 19.8 6.3 0.001 18.9 6.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KOG97746.1 - 0.002 18.2 8.6 0.0041 17.2 8.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 KOG97746.1 - 0.007 16.2 4.8 0.013 15.3 4.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 KOG97746.1 - 0.011 15.5 5.3 0.024 14.4 5.3 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-ANAPC11 PF12861.7 KOG97746.1 - 0.038 14.0 0.8 0.081 13.0 0.8 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 KOG97746.1 - 0.054 13.3 6.1 0.11 12.4 6.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KOG97746.1 - 0.07 13.4 2.9 0.19 12.0 2.9 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_6 PF14835.6 KOG97746.1 - 0.65 9.9 2.3 1.4 8.8 2.3 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Bromodomain PF00439.25 KOG97747.1 - 8.4e-09 35.4 0.1 2.1e-08 34.1 0.1 1.7 1 0 0 1 1 1 1 Bromodomain Nramp PF01566.18 KOG97748.1 - 8.9e-97 324.3 13.4 1.2e-96 323.8 13.4 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein DNA_mis_repair PF01119.19 KOG97749.1 - 8.9e-11 41.5 0.2 1.6e-10 40.7 0.2 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 KOG97749.1 - 7.2e-09 35.6 0.5 1.7e-08 34.3 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KOG97749.1 - 2.8e-05 24.6 0.1 5.8e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4668 PF15701.5 KOG97750.1 - 1e-49 168.4 3.4 1.2e-49 168.2 3.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4668) DUF3328 PF11807.8 KOG97750.1 - 0.012 15.3 0.4 2 8.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) SRP1_TIP1 PF00660.17 KOG97751.1 - 2.8e-26 91.5 0.0 3.8e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 Seripauperin and TIP1 family COX6B PF02297.17 KOG97752.1 - 7.2e-20 71.0 5.2 8.3e-20 70.8 5.2 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 KOG97752.1 - 0.048 13.7 2.0 0.079 13.0 2.0 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 KOG97752.1 - 0.064 13.2 0.4 0.088 12.8 0.4 1.3 1 0 0 1 1 1 0 APOBEC-like C-terminal domain ketoacyl-synt PF00109.26 KOG97752.1 - 0.14 11.7 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain RIC1 PF07064.13 KOG97753.1 - 7.7e-16 58.3 6.5 2.7e-15 56.5 6.5 1.9 1 1 0 1 1 1 1 RIC1 SRP1_TIP1 PF00660.17 KOG97754.1 - 4.2e-09 36.4 0.7 4.2e-09 36.4 0.7 1.8 2 0 0 2 2 2 1 Seripauperin and TIP1 family Suf PF05843.14 KOG97754.1 - 0.011 15.7 2.3 0.015 15.3 2.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TMEM174 PF15029.6 KOG97754.1 - 0.1 12.3 5.4 0.15 11.7 5.4 1.3 1 0 0 1 1 1 0 Transmembrane protein 174 Podoplanin PF05808.11 KOG97754.1 - 0.2 11.7 3.0 0.34 11.0 3.0 1.5 1 0 0 1 1 1 0 Podoplanin RAP1 PF07218.11 KOG97754.1 - 2.9 6.1 15.4 3.7 5.7 15.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Thioredoxin PF00085.20 KOG97756.1 - 4.9e-33 113.2 0.5 5.5e-33 113.0 0.5 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KOG97756.1 - 1.2e-07 32.2 0.3 1.1e-06 29.1 0.3 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 KOG97756.1 - 1.6e-07 31.2 0.1 1.8e-07 31.0 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KOG97756.1 - 4.1e-07 30.2 0.1 0.00021 21.6 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 KOG97756.1 - 1.4e-05 25.0 0.1 1.7e-05 24.7 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KOG97756.1 - 3.2e-05 23.7 0.1 0.00028 20.6 0.0 1.9 1 1 1 2 2 2 1 Redoxin DIM1 PF02966.16 KOG97756.1 - 0.00091 19.0 0.0 0.00099 18.9 0.0 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_7 PF13899.6 KOG97756.1 - 0.005 17.0 0.1 0.0087 16.2 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 KOG97756.1 - 0.0073 16.1 0.1 0.014 15.2 0.1 1.4 1 1 0 1 1 1 1 F plasmid transfer operon protein OST3_OST6 PF04756.13 KOG97756.1 - 0.0095 15.3 0.0 0.0099 15.3 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family HyaE PF07449.11 KOG97756.1 - 0.037 14.0 0.0 0.057 13.4 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Phosducin PF02114.16 KOG97756.1 - 0.097 11.6 0.0 0.1 11.5 0.0 1.0 1 0 0 1 1 1 0 Phosducin TPP_enzyme_N PF02776.18 KOG97757.1 - 3.4e-32 111.4 0.1 5.1e-32 110.8 0.1 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 KOG97757.1 - 1.3e-27 96.3 0.0 1.3e-26 93.0 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 KOG97757.1 - 3e-14 53.1 0.0 5.4e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain OCC1 PF15506.6 KOG97757.1 - 0.022 14.9 0.3 0.89 9.7 0.1 2.8 2 0 0 2 2 2 0 OCC1 family Cnd3 PF12719.7 KOG97758.1 - 0.00068 18.9 0.7 0.056 12.6 0.1 2.7 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain NeuB PF03102.14 KOG97758.1 - 0.042 13.3 1.6 0.54 9.7 1.6 2.2 2 0 0 2 2 2 0 NeuB family Vac14_Fab1_bd PF12755.7 KOG97758.1 - 0.06 13.9 0.6 2.1 9.0 0.0 3.3 3 1 1 4 4 4 0 Vacuolar 14 Fab1-binding region HEAT PF02985.22 KOG97758.1 - 0.061 13.6 0.1 4.3 7.9 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat ADIP PF11559.8 KOG97758.1 - 0.33 11.0 18.9 6.5 6.8 0.0 3.2 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding BLOC1_2 PF10046.9 KOG97758.1 - 0.92 9.8 22.5 0.026 14.8 12.3 3.4 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ERM PF00769.19 KOG97758.1 - 2.3 8.0 24.7 0.34 10.7 19.0 2.4 2 1 0 2 2 2 0 Ezrin/radixin/moesin family RTA1 PF04479.13 KOG97759.1 - 2.2e-48 164.6 18.0 2.8e-48 164.3 18.0 1.1 1 0 0 1 1 1 1 RTA1 like protein Ferric_reduct PF01794.19 KOG97760.1 - 5.2e-19 68.6 13.2 5.2e-19 68.6 13.2 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 KOG97760.1 - 0.0032 17.5 0.1 0.0088 16.1 0.1 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 KOG97760.1 - 0.021 15.0 0.0 0.068 13.3 0.0 2.0 1 1 0 1 1 1 0 Ferric reductase NAD binding domain Ribosomal_S2 PF00318.20 KOG97761.1 - 1.1e-25 90.2 0.0 1.4e-13 50.6 0.0 2.3 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 KOG97761.1 - 0.013 16.9 12.1 0.026 15.9 12.1 1.5 1 0 0 1 1 1 0 40S ribosomal protein SA C-terminus DUF4786 PF16027.5 KOG97761.1 - 0.16 12.5 0.0 0.3 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4786) DUF2781 PF10914.8 KOG97763.1 - 7.2e-41 140.0 10.9 8e-41 139.9 10.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Fcf2 PF08698.11 KOG97764.1 - 2.2e-32 111.3 3.7 2.2e-32 111.3 3.7 2.1 3 0 0 3 3 3 1 Fcf2 pre-rRNA processing FAM76 PF16046.5 KOG97765.1 - 0.68 9.2 10.1 0.92 8.8 10.1 1.2 1 0 0 1 1 1 0 FAM76 protein WD40 PF00400.32 KOG97768.1 - 1e-07 32.5 2.2 19 6.3 0.0 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat PQQ_3 PF13570.6 KOG97768.1 - 0.081 13.4 0.0 28 5.4 0.1 3.4 3 0 0 3 3 3 0 PQQ-like domain PI3K_1B_p101 PF10486.9 KOG97768.1 - 0.75 7.5 16.6 0.019 12.8 6.8 2.0 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit FA_hydroxylase PF04116.13 KOG97769.1 - 6.8e-22 78.2 17.0 6.8e-22 78.2 17.0 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Glyco_hydro_47 PF01532.20 KOG97770.1 - 1.5e-63 215.3 0.0 2.5e-63 214.6 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 SHMT PF00464.19 KOG97771.1 - 1.8e-206 685.4 0.0 2.1e-206 685.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 KOG97771.1 - 6.8e-05 22.2 0.0 0.00013 21.3 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KOG97771.1 - 0.00016 20.7 0.0 0.00024 20.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KOG97771.1 - 0.0012 18.2 0.0 0.0025 17.2 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase RNase_T PF00929.24 KOG97772.1 - 5.3e-40 137.7 0.1 6.6e-40 137.3 0.1 1.1 1 0 0 1 1 1 1 Exonuclease FliD_N PF02465.18 KOG97772.1 - 0.065 13.9 0.5 0.12 13.1 0.5 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus tRNA_synthFbeta PF17759.1 KOG97773.1 - 9.7e-39 133.0 0.0 1.7e-38 132.3 0.0 1.4 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 KOG97773.1 - 2.2e-31 107.9 1.4 1.9e-28 98.5 0.3 2.6 2 1 0 2 2 2 2 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 KOG97773.1 - 1.2e-26 93.4 0.0 2.7e-26 92.3 0.0 1.6 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 KOG97773.1 - 3.8e-15 55.9 0.1 3e-14 53.1 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetase B5 domain Ribosomal_L22e PF01776.17 KOG97774.1 - 4e-40 136.6 0.4 4.9e-40 136.3 0.4 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Methyltransf_34 PF11312.8 KOG97775.1 - 7.1e-93 311.2 0.1 8.2e-93 311.0 0.1 1.0 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase LRRC37 PF15779.5 KOG97775.1 - 0.059 13.7 0.3 0.096 13.1 0.3 1.3 1 0 0 1 1 1 0 Leucine-rich repeat-containing protein 37 family Methyltransf_23 PF13489.6 KOG97775.1 - 0.12 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TMEM208_SND2 PF05620.11 KOG97777.1 - 1.2e-42 145.6 0.2 1.3e-42 145.4 0.2 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 VirB3 PF05101.13 KOG97777.1 - 7.7 6.8 6.9 2.9 8.2 0.4 2.1 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein SPC22 PF04573.12 KOG97778.1 - 2.9e-56 189.6 6.0 3.1e-56 189.5 6.0 1.0 1 0 0 1 1 1 1 Signal peptidase subunit HIM1 PF08732.10 KOG97778.1 - 0.022 14.3 0.1 0.032 13.8 0.1 1.3 1 0 0 1 1 1 0 HIM1 DUF5426 PF17473.2 KOG97778.1 - 0.88 9.8 4.6 0.45 10.8 1.4 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5426) PPR PF01535.20 KOG97779.1 - 1.4e-06 28.1 1.5 44 4.6 0.0 8.4 8 0 0 8 8 8 0 PPR repeat PPR_long PF17177.4 KOG97779.1 - 1.7e-06 27.5 2.0 0.0012 18.3 0.0 2.9 1 1 2 3 3 3 2 Pentacotripeptide-repeat region of PRORP Swm2 PF17083.5 KOG97779.1 - 0.0009 19.3 1.1 0.003 17.6 0.2 2.5 2 0 0 2 2 2 1 Nucleolar protein Swm2 RPM2 PF08579.11 KOG97779.1 - 0.1 13.0 9.5 0.52 10.7 0.8 4.2 3 2 1 4 4 4 0 Mitochondrial ribonuclease P subunit (RPM2) PPR_2 PF13041.6 KOG97779.1 - 0.33 11.2 24.0 3.2 8.0 0.1 8.8 9 2 2 11 11 11 0 PPR repeat family Ribonuc_red_lgN PF00317.21 KOG97779.1 - 0.57 10.2 2.1 11 6.1 0.1 4.1 3 2 1 4 4 4 0 Ribonucleotide reductase, all-alpha domain MA3 PF02847.17 KOG97779.1 - 2.7 8.0 5.4 2.9 7.9 0.2 3.5 4 1 1 5 5 5 0 MA3 domain rRNA_processing PF08524.11 KOG97780.1 - 3.3e-41 140.8 31.5 3.7e-41 140.6 31.5 1.0 1 0 0 1 1 1 1 rRNA processing DUF4407 PF14362.6 KOG97780.1 - 4.2 6.6 10.8 5.2 6.3 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Vfa1 PF08432.10 KOG97780.1 - 6 7.2 19.2 8.1 6.7 19.2 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 GTP_EFTU PF00009.27 KOG97781.1 - 1.6e-61 207.3 0.1 2.9e-61 206.4 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 KOG97781.1 - 9.3e-36 122.3 0.0 2.2e-35 121.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 KOG97781.1 - 4.6e-30 103.5 0.0 1.1e-29 102.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 KOG97781.1 - 2.2e-24 85.3 0.0 4.4e-24 84.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOG97781.1 - 4.7e-14 52.5 0.6 2.1e-13 50.5 0.3 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 KOG97781.1 - 3.7e-06 26.8 0.0 1.1e-05 25.2 0.0 1.8 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain AvrPtoB_bdg PF16847.5 KOG97781.1 - 2.3e-05 24.8 0.0 0.0047 17.4 0.0 2.6 2 0 0 2 2 2 1 Avirulence AvrPtoB, BAK1-binding domain MMR_HSR1 PF01926.23 KOG97781.1 - 0.011 15.8 0.1 0.032 14.3 0.1 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase ADH_zinc_N PF00107.26 KOG97782.1 - 8.8e-30 103.4 0.7 1.1e-29 103.0 0.0 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOG97782.1 - 1.1e-26 92.9 0.0 6.4e-26 90.4 0.0 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 KOG97782.1 - 3.2e-10 39.9 0.0 6.8e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 KOG97782.1 - 5.9e-06 27.4 0.0 1.3e-05 26.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 KOG97782.1 - 0.0012 18.5 0.0 0.0023 17.5 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 KOG97782.1 - 0.0027 17.1 0.1 0.0047 16.3 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Med14 PF08638.11 KOG97783.1 - 7.6e-57 191.8 3.0 7.6e-57 191.8 3.0 2.0 2 0 0 2 2 2 1 Mediator complex subunit MED14 CDT1 PF08839.11 KOG97783.1 - 0.036 14.4 0.2 0.089 13.1 0.2 1.6 1 0 0 1 1 1 0 DNA replication factor CDT1 like VASt PF16016.5 KOG97784.1 - 1.1e-33 116.8 0.4 2.6e-33 115.6 0.4 1.7 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 KOG97784.1 - 2.9e-25 88.4 0.5 6.6e-25 87.2 0.5 1.7 1 0 0 1 1 1 1 GRAM domain USP8_dimer PF08969.11 KOG97785.1 - 0.00012 22.2 0.0 0.00025 21.2 0.0 1.7 1 1 0 1 1 1 1 USP8 dimerisation domain zf-C2H2_jaz PF12171.8 KOG97786.1 - 6e-10 39.1 3.0 6e-10 39.1 3.0 1.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KOG97786.1 - 0.0012 19.2 0.1 0.002 18.5 0.1 1.3 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.12 KOG97786.1 - 0.044 13.6 1.2 0.082 12.7 1.2 1.4 1 0 0 1 1 1 0 U1 zinc finger zf-met PF12874.7 KOG97786.1 - 0.42 11.1 4.2 0.34 11.3 2.4 1.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HE PF16278.5 KOG97786.1 - 0.6 10.6 3.4 2.4 8.7 0.9 2.6 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Ribosomal_L16 PF00252.18 KOG97787.1 - 1.3e-41 141.7 0.1 1.6e-41 141.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e RCC1 PF00415.18 KOG97788.1 - 2.6e-22 79.2 0.1 0.00034 21.2 0.0 6.2 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOG97788.1 - 1.2e-13 50.4 8.0 3.8e-10 39.3 0.1 4.8 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat Ribosomal_S22 PF08136.11 KOG97788.1 - 0.12 12.8 0.0 0.37 11.2 0.0 1.8 1 0 0 1 1 1 0 30S ribosomal protein subunit S22 family V-SNARE_C PF12352.8 KOG97789.1 - 5e-07 29.9 2.2 6.5e-07 29.5 2.2 1.2 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 KOG97789.1 - 2.9e-05 23.9 0.6 4.1e-05 23.4 0.6 1.2 1 0 0 1 1 1 1 Sec20 Fusion_gly PF00523.18 KOG97789.1 - 0.11 10.7 0.1 0.11 10.7 0.1 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 Lectin_leg-like PF03388.13 KOG97791.1 - 5.4e-32 111.0 0.0 7.5e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Sugar_tr PF00083.24 KOG97792.1 - 1.8e-171 571.0 35.3 2e-171 570.8 35.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG97792.1 - 9.5e-31 107.0 31.5 1.7e-27 96.3 19.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4118 PF13493.6 KOG97792.1 - 1.6 8.5 8.9 0.12 12.2 2.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4118) Sugar_tr PF00083.24 KOG97793.1 - 1.7e-171 571.1 35.3 2e-171 570.9 35.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG97793.1 - 1.3e-30 106.5 32.0 2.8e-27 95.6 20.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4118 PF13493.6 KOG97793.1 - 1.6 8.5 8.9 0.12 12.2 2.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4118) EMP24_GP25L PF01105.24 KOG97794.1 - 5.1 7.0 6.9 9.9 6.1 0.2 2.9 2 1 1 3 3 3 0 emp24/gp25L/p24 family/GOLD EMP70 PF02990.16 KOG97795.1 - 9.7e-196 651.4 10.3 1.6e-195 650.7 10.3 1.3 1 0 0 1 1 1 1 Endomembrane protein 70 Rax2 PF12768.7 KOG97796.1 - 7.6e-57 192.2 1.4 7.6e-57 192.2 1.4 4.4 4 1 0 4 4 4 2 Cortical protein marker for cell polarity Actin PF00022.19 KOG97797.1 - 1.4e-53 182.0 0.0 1.4e-52 178.7 0.0 1.9 1 1 0 1 1 1 1 Actin Peptidase_C70 PF12385.8 KOG97797.1 - 0.028 14.4 0.0 0.046 13.7 0.0 1.3 1 0 0 1 1 1 0 Papain-like cysteine protease AvrRpt2 SMC_N PF02463.19 KOG97798.1 - 6.9e-80 267.6 11.2 1.8e-79 266.3 11.2 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KOG97798.1 - 6e-24 84.6 0.0 2.1e-23 82.9 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 KOG97798.1 - 1.9e-10 41.0 18.3 1.1e-05 25.4 1.1 4.7 2 2 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KOG97798.1 - 2.6e-05 24.1 22.9 2.6e-05 24.1 22.9 3.8 3 1 1 4 4 4 1 AAA ATPase domain AAA_29 PF13555.6 KOG97798.1 - 0.00042 20.0 0.0 0.00092 18.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 KOG97798.1 - 1.7 9.2 0.0 1.7 9.2 0.0 6.7 4 2 0 4 4 4 0 ABC transporter DUF1664 PF07889.12 KOG97798.1 - 5.4 7.1 72.8 0.28 11.2 6.3 8.2 2 2 5 8 8 8 0 Protein of unknown function (DUF1664) Gaa1 PF04114.14 KOG97800.1 - 4e-127 425.2 9.4 5.6e-127 424.8 9.4 1.2 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component PHO4 PF01384.20 KOG97800.1 - 3.6 6.6 8.1 90 1.9 8.0 2.3 1 1 2 3 3 3 0 Phosphate transporter family Aminotran_1_2 PF00155.21 KOG97801.1 - 4e-36 125.0 0.0 6e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KOG97801.1 - 0.022 14.1 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase DnaJ_C PF01556.18 KOG97802.1 - 6.8e-27 94.4 0.1 1e-26 93.8 0.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOG97802.1 - 2.5e-24 85.1 2.0 4.8e-24 84.3 2.0 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KOG97802.1 - 4.8e-10 39.7 11.6 9.9e-10 38.6 11.6 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KOG97802.1 - 0.015 15.2 11.9 0.18 11.8 2.7 2.5 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF4460 PF14687.6 KOG97802.1 - 0.17 11.9 0.9 0.58 10.2 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4460) zf-CHY PF05495.12 KOG97802.1 - 1.1 9.8 5.2 3.6 8.1 0.4 2.5 2 0 0 2 2 2 0 CHY zinc finger Cytochrom_c3_2 PF14537.6 KOG97802.1 - 3.2 8.3 9.7 4 8.0 6.1 2.4 1 1 1 2 2 2 0 Cytochrome c3 Cytochrome_C7 PF14522.6 KOG97802.1 - 5.6 7.0 8.6 49 4.0 8.7 2.3 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c GEP5 PF17053.5 KOG97803.1 - 2.9e-56 190.8 1.9 3.4e-56 190.6 1.9 1.0 1 0 0 1 1 1 1 Genetic interactor of prohibitin 5 Sulfate_transp PF00916.20 KOG97804.1 - 1.1e-129 432.5 10.9 1.4e-129 432.2 10.9 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 KOG97804.1 - 0.00029 20.5 0.0 0.00064 19.3 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 KOG97804.1 - 0.02 15.2 0.1 0.071 13.5 0.1 1.8 2 0 0 2 2 2 0 STAS domain MFS_MOT1 PF16983.5 KOG97804.1 - 4.5 7.7 9.3 0.13 12.7 0.8 2.5 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily Nyv1_N PF09426.10 KOG97805.1 - 1.3e-40 138.7 0.4 2.2e-40 137.9 0.4 1.4 1 0 0 1 1 1 1 Vacuolar R-SNARE Nyv1 N terminal Synaptobrevin PF00957.21 KOG97805.1 - 1.9e-26 91.7 3.8 2.9e-26 91.1 3.8 1.2 1 0 0 1 1 1 1 Synaptobrevin RPM2 PF08579.11 KOG97806.1 - 0.05 14.0 0.5 0.4 11.1 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial ribonuclease P subunit (RPM2) PHD PF00628.29 KOG97807.1 - 0.001 18.9 1.1 0.001 18.9 1.1 2.0 2 0 0 2 2 2 1 PHD-finger AAA_23 PF13476.6 KOG97807.1 - 10 6.6 12.5 4.1 7.9 0.3 2.6 3 0 0 3 3 3 0 AAA domain Pkinase PF00069.25 KOG97808.1 - 2.7e-66 223.7 2.5 2.4e-64 217.3 2.5 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97808.1 - 2.8e-37 128.4 0.4 1.3e-36 126.3 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase KA1 PF02149.19 KOG97808.1 - 3.1e-17 62.1 0.0 6e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 KOG97808.1 - 7.6e-07 28.7 0.0 1.4e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOG97808.1 - 6.1e-05 22.5 0.1 0.00018 21.0 0.1 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOG97808.1 - 0.001 17.9 3.0 0.004 16.0 0.0 2.7 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KOG97808.1 - 0.0037 17.2 0.1 0.028 14.3 0.1 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOG97808.1 - 0.0071 15.3 0.1 0.0071 15.3 0.1 2.3 2 0 0 2 2 2 1 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 KOG97808.1 - 0.02 14.4 1.0 0.093 12.2 0.1 2.4 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL RIO1 PF01163.22 KOG97808.1 - 0.45 10.1 2.4 0.43 10.2 0.2 2.1 2 0 0 2 2 2 0 RIO1 family F-box PF00646.33 KOG97809.1 - 0.00057 19.7 0.5 0.0012 18.7 0.5 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOG97809.1 - 0.00087 19.1 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 F-box-like Fungal_trans PF04082.18 KOG97810.1 - 9.9e-43 146.1 3.2 9.9e-43 146.1 3.2 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG97810.1 - 3.8e-11 42.9 11.2 6.2e-11 42.2 11.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FlxA PF14282.6 KOG97810.1 - 0.6 10.1 6.7 0.064 13.2 1.7 1.9 2 0 0 2 2 2 0 FlxA-like protein tRNA_bind_3 PF17176.4 KOG97811.1 - 0.025 14.9 0.0 0.026 14.8 0.0 1.1 1 0 0 1 1 1 0 tRNA-binding domain adh_short PF00106.25 KOG97812.1 - 1.3e-12 47.6 0.1 8.8e-12 44.9 0.1 2.3 1 1 0 1 1 1 1 short chain dehydrogenase DUF948 PF06103.11 KOG97812.1 - 0.035 14.3 0.0 0.072 13.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) adh_short_C2 PF13561.6 KOG97812.1 - 0.039 13.5 0.0 1.1 8.7 0.0 2.3 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase ANAPC9 PF12856.7 KOG97813.1 - 4.2e-17 62.4 0.0 7.2e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 9 CDC45 PF02724.14 KOG97814.1 - 1.9e-214 713.6 0.3 2.2e-214 713.4 0.3 1.0 1 0 0 1 1 1 1 CDC45-like protein YL1 PF05764.13 KOG97814.1 - 0.0031 17.7 6.1 0.0031 17.7 6.1 2.0 2 0 0 2 2 2 1 YL1 nuclear protein Merozoite_SPAM PF07133.11 KOG97814.1 - 0.0088 16.1 11.5 0.0088 16.1 11.5 2.4 2 1 1 3 3 3 1 Merozoite surface protein (SPAM) IFT57 PF10498.9 KOG97814.1 - 0.052 12.5 6.0 0.1 11.5 6.0 1.4 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Sigma70_ner PF04546.13 KOG97814.1 - 0.12 12.2 13.9 0.14 12.1 6.6 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region MGDG_synth PF06925.11 KOG97814.1 - 0.16 12.1 0.1 0.45 10.6 0.1 1.8 1 0 0 1 1 1 0 Monogalactosyldiacylglycerol (MGDG) synthase XAP5 PF04921.14 KOG97814.1 - 2.1 8.1 8.2 4 7.2 8.2 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator tRNA_int_endo PF01974.17 KOG97816.1 - 1.4e-23 82.8 0.3 2.6e-23 81.9 0.3 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 KOG97816.1 - 0.005 16.5 0.0 0.16 11.6 0.0 2.4 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain DUF4156 PF13698.6 KOG97816.1 - 0.16 12.3 0.2 0.28 11.5 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4156) AAA_5 PF07728.14 KOG97817.1 - 3.7e-126 415.7 1.0 4.4e-21 75.3 0.0 9.6 8 1 1 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 KOG97817.1 - 7.7e-54 180.4 0.5 3.6e-20 72.2 0.0 5.1 4 0 0 4 4 4 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 KOG97817.1 - 7.8e-34 116.0 0.0 3.8e-30 104.1 0.0 4.7 3 0 0 3 3 3 1 Midasin AAA lid domain AAA_3 PF07726.11 KOG97817.1 - 1.3e-32 112.4 0.0 1.8e-10 40.8 0.0 8.2 7 1 0 8 8 8 4 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KOG97817.1 - 7.2e-30 103.8 10.7 1.4e-06 27.9 1.4 7.0 7 0 0 7 7 6 5 P-loop containing dynein motor region AAA PF00004.29 KOG97817.1 - 2.1e-26 92.9 0.7 0.00043 20.7 0.0 7.9 7 0 0 7 7 7 4 ATPase family associated with various cellular activities (AAA) AAA_6 PF12774.7 KOG97817.1 - 2.4e-26 92.5 2.1 0.00048 19.2 0.0 10.3 9 2 0 9 9 9 4 Hydrolytic ATP binding site of dynein motor region AAA_16 PF13191.6 KOG97817.1 - 9.1e-24 84.7 5.8 0.00012 22.6 0.2 8.6 7 2 0 7 7 6 5 AAA ATPase domain Dynein_heavy PF03028.15 KOG97817.1 - 3.5e-22 78.7 0.0 5.7e-06 26.4 0.0 8.3 7 0 0 7 7 7 4 Dynein heavy chain region D6 P-loop domain Sigma54_activat PF00158.26 KOG97817.1 - 1.5e-18 67.1 0.1 0.0039 16.9 0.0 6.0 6 0 0 6 6 5 4 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 KOG97817.1 - 9.3e-18 64.7 0.3 0.0015 18.7 0.1 6.7 6 0 0 6 6 6 3 Sigma-54 interaction domain AAA_22 PF13401.6 KOG97817.1 - 2.4e-16 60.3 1.8 0.029 14.6 0.0 7.9 7 0 0 7 7 6 3 AAA domain AAA_18 PF13238.6 KOG97817.1 - 1.1e-15 58.3 16.6 0.019 15.5 0.1 8.9 8 0 0 8 8 6 4 AAA domain AAA_30 PF13604.6 KOG97817.1 - 1.1e-15 57.9 0.0 0.075 12.7 0.0 6.9 7 0 0 7 7 7 4 AAA domain TsaE PF02367.17 KOG97817.1 - 2.2e-15 56.8 3.6 0.051 13.6 0.1 6.7 6 0 0 6 6 6 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 KOG97817.1 - 2.3e-14 53.6 6.9 0.0046 17.0 0.0 8.7 8 1 0 8 8 6 1 AAA domain RNA_helicase PF00910.22 KOG97817.1 - 4.7e-13 49.5 1.2 0.069 13.5 0.0 7.2 7 0 0 7 7 6 2 RNA helicase T2SSE PF00437.20 KOG97817.1 - 6.6e-13 48.3 6.7 0.012 14.7 0.0 6.3 6 0 0 6 6 6 3 Type II/IV secretion system protein AAA_33 PF13671.6 KOG97817.1 - 3.8e-12 46.6 0.3 0.011 15.9 0.1 6.8 6 0 0 6 6 6 1 AAA domain Zeta_toxin PF06414.12 KOG97817.1 - 5.3e-12 45.4 0.1 0.19 11.0 0.0 6.9 7 0 0 7 7 6 2 Zeta toxin Rad17 PF03215.15 KOG97817.1 - 7.8e-11 42.2 4.3 1.3 8.9 0.0 7.0 6 0 0 6 6 6 3 Rad17 P-loop domain RsgA_GTPase PF03193.16 KOG97817.1 - 8.8e-11 42.0 8.0 0.063 13.2 0.3 5.7 6 0 0 6 6 5 3 RsgA GTPase Mg_chelatase PF01078.21 KOG97817.1 - 2.2e-10 40.3 1.1 2.4 7.5 0.0 8.6 10 0 0 10 10 9 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 KOG97817.1 - 3.2e-10 40.6 35.9 0.001 19.6 0.0 8.4 8 1 0 8 8 6 4 ABC transporter AAA_19 PF13245.6 KOG97817.1 - 5.2e-10 39.8 0.1 0.44 10.9 0.0 6.6 6 0 0 6 6 6 1 AAA domain PduV-EutP PF10662.9 KOG97817.1 - 4.1e-09 36.3 3.4 0.049 13.4 0.1 5.8 6 0 0 6 6 5 2 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 KOG97817.1 - 4.5e-09 36.1 3.8 0.11 12.0 0.0 5.4 6 0 0 6 6 4 2 AAA domain NACHT PF05729.12 KOG97817.1 - 1.7e-08 34.5 7.9 0.2 11.6 0.2 6.3 6 0 0 6 6 6 2 NACHT domain IstB_IS21 PF01695.17 KOG97817.1 - 3.3e-08 33.5 0.1 3 7.6 0.0 5.5 6 0 0 6 6 5 1 IstB-like ATP binding protein AAA_29 PF13555.6 KOG97817.1 - 3.5e-08 33.0 1.6 2 8.2 0.0 6.5 6 0 0 6 6 6 1 P-loop containing region of AAA domain KAP_NTPase PF07693.14 KOG97817.1 - 4e-08 32.9 1.2 0.17 11.1 0.0 5.5 5 0 0 5 5 5 2 KAP family P-loop domain RuvB_N PF05496.12 KOG97817.1 - 1.3e-07 31.5 2.0 0.22 11.2 0.0 5.7 6 0 0 6 6 6 1 Holliday junction DNA helicase RuvB P-loop domain SRP54 PF00448.22 KOG97817.1 - 1.3e-07 31.4 6.7 0.17 11.5 0.6 5.8 6 0 0 6 6 5 2 SRP54-type protein, GTPase domain AAA_28 PF13521.6 KOG97817.1 - 1.8e-07 31.5 6.3 5.9 7.1 0.0 6.5 6 0 0 6 6 6 0 AAA domain MMR_HSR1 PF01926.23 KOG97817.1 - 2.8e-07 30.6 3.5 14 5.8 0.2 6.8 6 0 0 6 6 6 0 50S ribosome-binding GTPase DUF815 PF05673.13 KOG97817.1 - 5.4e-07 29.0 1.0 0.14 11.3 0.1 5.0 5 0 0 5 5 5 1 Protein of unknown function (DUF815) TniB PF05621.11 KOG97817.1 - 7.1e-07 28.8 2.1 0.95 8.8 0.0 6.0 6 0 0 6 6 6 1 Bacterial TniB protein Roc PF08477.13 KOG97817.1 - 7.6e-07 29.4 6.7 4.4 7.6 0.2 7.1 7 0 0 7 7 7 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KOG97817.1 - 5.3e-06 26.0 3.4 8.3 5.8 0.1 6.5 6 0 0 6 6 6 0 Signal recognition particle receptor beta subunit PhoH PF02562.16 KOG97817.1 - 1.1e-05 25.0 0.6 3.8 6.9 0.1 5.1 5 0 0 5 5 5 0 PhoH-like protein AAA_8 PF12780.7 KOG97817.1 - 1.9e-05 24.1 0.1 2.9 7.2 0.0 5.8 5 0 0 5 5 5 1 P-loop containing dynein motor region D4 ATP-synt_ab PF00006.25 KOG97817.1 - 8.7e-05 22.3 0.2 5 6.7 0.0 3.7 4 0 0 4 4 3 0 ATP synthase alpha/beta family, nucleotide-binding domain ATPase PF06745.13 KOG97817.1 - 0.00012 21.6 0.8 2 7.7 0.0 4.4 4 0 0 4 4 4 2 KaiC ATP_bind_1 PF03029.17 KOG97817.1 - 0.00018 21.4 6.0 8.1 6.1 0.0 5.6 5 0 0 5 5 5 0 Conserved hypothetical ATP binding protein CPT PF07931.12 KOG97817.1 - 0.00095 19.0 0.6 12 5.7 0.0 6.0 5 1 0 5 5 5 0 Chloramphenicol phosphotransferase-like protein dNK PF01712.19 KOG97817.1 - 0.0012 18.8 4.5 16 5.3 0.0 5.9 5 0 0 5 5 5 0 Deoxynucleoside kinase FtsK_SpoIIIE PF01580.18 KOG97817.1 - 0.0034 16.8 0.7 4.2 6.7 0.1 5.0 5 0 0 5 5 5 0 FtsK/SpoIIIE family PIF1 PF05970.14 KOG97817.1 - 0.0035 16.6 1.1 2.9 7.0 0.0 4.5 4 0 0 4 4 4 1 PIF1-like helicase NTPase_1 PF03266.15 KOG97817.1 - 0.0094 15.9 14.7 3.3 7.6 0.8 6.6 8 0 0 8 8 6 0 NTPase CbiA PF01656.23 KOG97817.1 - 0.023 14.8 3.8 1.6 8.8 0.1 4.7 4 0 0 4 4 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 KOG97817.1 - 0.025 14.5 7.8 12 5.8 0.4 5.7 6 0 0 6 6 6 0 Molybdopterin guanine dinucleotide synthesis protein B PRK PF00485.18 KOG97817.1 - 0.031 14.0 0.0 18 5.0 0.0 4.0 4 0 0 4 4 2 0 Phosphoribulokinase / Uridine kinase family ResIII PF04851.15 KOG97817.1 - 0.12 12.4 15.9 1.3 9.0 0.2 6.2 6 0 0 6 6 5 0 Type III restriction enzyme, res subunit Ago_PAZ PF18309.1 KOG97817.1 - 0.17 12.6 1.1 0.58 10.9 1.1 1.9 1 0 0 1 1 1 0 Argonaute PAZ domain DNA_pol_A_exo1 PF01612.20 KOG97818.1 - 0.0056 16.4 1.6 0.018 14.8 0.2 2.4 2 1 0 2 2 2 1 3'-5' exonuclease DUF1818 PF08848.11 KOG97818.1 - 0.011 15.8 0.1 0.021 14.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1818) PRMT5 PF05185.16 KOG97818.1 - 0.035 13.9 0.0 3 7.7 0.0 2.3 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase CHORD PF04968.12 KOG97818.1 - 0.059 14.1 4.9 0.13 13.0 4.9 1.6 1 0 0 1 1 1 0 CHORD RhoGAP PF00620.27 KOG97818.1 - 0.13 12.1 0.7 0.34 10.7 0.1 1.9 2 0 0 2 2 2 0 RhoGAP domain SKA2 PF16740.5 KOG97818.1 - 0.14 11.9 2.2 21 4.9 0.4 3.1 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 BTB_2 PF02214.22 KOG97820.1 - 1.2e-06 28.8 3.1 0.027 14.8 0.2 2.9 2 1 0 2 2 2 2 BTB/POZ domain Pro-NT_NN PF07421.11 KOG97820.1 - 0.18 12.0 2.2 0.23 11.7 0.3 2.1 2 1 0 2 2 2 0 Neurotensin/neuromedin N precursor Redoxin PF08534.10 KOG97821.1 - 1.6e-32 112.3 0.2 1.7e-32 112.2 0.2 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 KOG97821.1 - 5e-06 26.4 0.1 6.4e-06 26.1 0.1 1.3 1 0 0 1 1 1 1 AhpC/TSA family Alkyl_sulf_C PF14864.6 KOG97821.1 - 0.072 13.4 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal Flocculin_t3 PF13928.6 KOG97822.1 - 2.2e-16 60.1 19.6 2.2e-16 60.1 19.6 3.0 3 0 0 3 3 3 1 Flocculin type 3 repeat Phage_tail_2 PF06199.11 KOG97822.1 - 0.11 12.6 0.4 0.13 12.3 0.4 1.1 1 0 0 1 1 1 0 Phage tail tube protein MF_alpha_N PF05436.11 KOG97822.1 - 9.9 6.1 7.8 3 7.8 2.4 2.3 2 1 1 3 3 3 0 Mating factor alpha precursor N-terminus Pkinase PF00069.25 KOG97823.1 - 2.1e-67 227.3 0.0 3.3e-67 226.6 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97823.1 - 6.8e-31 107.5 0.0 9.8e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOG97823.1 - 2.3e-06 26.8 0.1 3e-06 26.5 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOG97823.1 - 7.1e-05 22.3 0.2 0.00025 20.5 0.2 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOG97823.1 - 0.00086 19.3 1.0 0.0022 17.9 0.0 2.0 2 1 1 3 3 3 1 Phosphotransferase enzyme family FTA2 PF13095.6 KOG97823.1 - 0.034 13.8 0.0 0.057 13.0 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 KOG97823.1 - 0.037 13.3 0.0 0.35 10.2 0.0 2.1 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 KOG97823.1 - 0.066 12.8 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Avl9 PF09794.9 KOG97824.1 - 4.2e-152 506.2 0.3 7.1e-152 505.5 0.3 1.4 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 KOG97824.1 - 0.0001 22.0 14.3 0.018 14.6 0.0 3.8 4 0 0 4 4 4 2 Uncharacterized conserved protein (DUF2347) DENN PF02141.21 KOG97824.1 - 0.00014 21.8 0.7 0.0042 17.0 0.7 2.3 1 1 0 1 1 1 1 DENN (AEX-3) domain SPA PF08616.10 KOG97824.1 - 0.0049 16.8 0.8 0.15 12.1 0.2 2.8 2 1 0 2 2 2 1 Stabilization of polarity axis Afi1 PF07792.12 KOG97824.1 - 0.023 15.2 0.0 0.023 15.2 0.0 5.5 3 1 1 5 5 5 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Lactamase_B_6 PF16661.5 KOG97825.1 - 5.2e-79 264.2 0.0 8.8e-79 263.4 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 KOG97825.1 - 2.4e-21 76.7 2.3 2.7e-20 73.2 0.3 3.9 3 2 1 4 4 4 2 Cleavage and polyadenylation factor 2 C-terminal Rep_fac-A_3 PF08661.11 KOG97825.1 - 0.041 14.2 0.0 0.15 12.4 0.0 2.0 1 0 0 1 1 1 0 Replication factor A protein 3 FAM176 PF14851.6 KOG97825.1 - 2.5 7.7 7.7 1 9.0 0.3 2.4 2 0 0 2 2 2 0 FAM176 family SF1-HH PF16275.5 KOG97826.1 - 1.4e-41 141.4 2.0 2.5e-41 140.5 2.0 1.4 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 KOG97826.1 - 1.4e-06 28.0 0.0 3.1e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.23 KOG97826.1 - 2.7e-06 27.2 8.4 4.9e-06 26.4 0.7 2.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 KOG97826.1 - 2.8e-05 24.0 0.6 0.013 15.5 0.1 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 KOG97826.1 - 0.0014 18.4 1.3 0.0014 18.4 1.3 2.5 2 0 0 2 2 2 1 Zinc knuckle Prim_Zn_Ribbon PF08273.12 KOG97826.1 - 0.077 13.3 3.9 0.17 12.2 3.9 1.6 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase zf-CCHC_4 PF14392.6 KOG97826.1 - 1.2 8.9 5.4 2.8 7.8 1.2 2.3 2 0 0 2 2 2 0 Zinc knuckle HAT PF02184.16 KOG97827.1 - 5.6e-20 71.0 41.1 4.5e-10 39.3 1.0 8.7 9 0 0 9 9 8 5 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 KOG97827.1 - 2.2e-18 65.4 0.1 0.28 12.1 0.0 9.1 6 2 4 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOG97827.1 - 3.7e-07 30.5 0.0 0.0089 16.5 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOG97827.1 - 8.7e-06 25.8 0.0 0.012 15.9 0.0 4.5 4 0 0 4 4 3 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KOG97827.1 - 6.3e-05 23.0 3.0 6.3e-05 23.0 3.0 4.9 5 2 0 5 5 5 1 Mad3/BUB1 homology region 1 Suf PF05843.14 KOG97827.1 - 0.0028 17.7 24.4 0.12 12.4 0.4 5.4 3 2 0 4 4 4 2 Suppressor of forked protein (Suf) TPR_2 PF07719.17 KOG97827.1 - 0.0029 17.6 17.1 2 8.7 0.2 7.8 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOG97827.1 - 0.022 15.4 0.4 12 6.6 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 KOG97827.1 - 0.039 14.0 16.0 0.029 14.5 2.0 5.0 4 1 1 5 5 5 0 U3 small nucleolar RNA-associated protein 6 TPR_8 PF13181.6 KOG97827.1 - 0.043 14.0 17.8 3.8 8.0 0.0 7.3 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOG97827.1 - 0.056 13.5 3.7 23 5.3 0.2 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOG97827.1 - 0.22 12.2 7.1 72 4.3 0.1 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOG97827.1 - 1 9.3 6.5 8.7 6.4 0.1 5.0 7 0 0 7 7 7 0 Tetratricopeptide repeat Abhydrolase_2 PF02230.16 KOG97828.1 - 4.5e-76 255.4 0.0 5.1e-76 255.3 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 KOG97828.1 - 1.7e-08 34.0 0.1 0.00028 20.3 0.0 3.0 2 1 1 3 3 3 2 Serine aminopeptidase, S33 FSH1 PF03959.13 KOG97828.1 - 1.9e-08 34.2 0.0 8.9e-08 32.1 0.0 1.9 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 KOG97828.1 - 1.2e-07 31.6 0.0 1.7e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 KOG97828.1 - 6.9e-06 26.8 0.0 8.4e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KOG97828.1 - 0.00017 21.1 0.0 0.0054 16.2 0.0 2.2 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 KOG97828.1 - 0.0064 16.4 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 KOG97828.1 - 0.02 14.5 0.9 0.2 11.3 0.7 2.4 1 1 1 2 2 2 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 KOG97828.1 - 0.025 14.4 0.0 0.05 13.5 0.0 1.5 2 0 0 2 2 2 0 Lipase (class 3) NPP PF08384.10 KOG97828.1 - 0.098 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Pro-opiomelanocortin, N-terminal region BAAT_C PF08840.11 KOG97828.1 - 0.17 11.8 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF2974 PF11187.8 KOG97828.1 - 0.17 11.4 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Mod_r PF07200.13 KOG97829.1 - 1.6e-18 67.2 9.2 2e-18 66.9 9.2 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein GAS PF13851.6 KOG97829.1 - 4.1e-05 23.0 4.0 5.5e-05 22.6 4.0 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Retrotrans_gag PF03732.17 KOG97829.1 - 0.0027 18.0 2.3 0.68 10.2 0.3 3.0 1 1 2 3 3 3 1 Retrotransposon gag protein BLOC1_2 PF10046.9 KOG97829.1 - 0.0028 17.9 4.3 0.33 11.3 0.3 2.6 1 1 0 2 2 2 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 TACC_C PF05010.14 KOG97829.1 - 0.0037 17.1 5.0 0.0053 16.6 5.0 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Occludin_ELL PF07303.13 KOG97829.1 - 0.0073 17.0 6.5 1.3 9.8 2.2 2.2 1 1 1 2 2 2 2 Occludin homology domain DUF2959 PF11172.8 KOG97829.1 - 0.0081 16.3 1.7 0.01 16.0 1.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2959) rRNA_proc-arch PF13234.6 KOG97829.1 - 0.015 15.3 4.6 0.016 15.2 2.7 1.9 1 1 1 2 2 2 0 rRNA-processing arch domain PIN_8 PF18476.1 KOG97829.1 - 0.019 14.9 2.9 0.029 14.2 2.9 1.4 1 1 0 1 1 1 0 PIN like domain T4SS PF07996.11 KOG97829.1 - 0.022 15.1 0.1 0.027 14.9 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion system proteins bZIP_1 PF00170.21 KOG97829.1 - 0.025 14.7 1.3 4.4 7.5 0.1 2.5 2 0 0 2 2 2 0 bZIP transcription factor HNOBA PF07701.14 KOG97829.1 - 0.044 13.2 2.7 0.43 10.0 0.2 2.1 2 0 0 2 2 2 0 Heme NO binding associated TMPIT PF07851.13 KOG97829.1 - 0.063 12.5 1.4 0.084 12.1 1.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein GP41 PF00517.17 KOG97829.1 - 0.073 13.0 0.2 0.097 12.6 0.2 1.2 1 0 0 1 1 1 0 Retroviral envelope protein H-kinase_dim PF02895.14 KOG97829.1 - 0.16 12.4 1.0 9 6.8 0.1 2.2 2 0 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain Syntaxin-6_N PF09177.11 KOG97829.1 - 0.18 12.4 3.1 0.77 10.4 0.9 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Prefoldin_2 PF01920.20 KOG97829.1 - 0.2 11.7 4.6 0.81 9.7 4.3 2.1 1 1 0 1 1 1 0 Prefoldin subunit DASH_Dam1 PF08653.10 KOG97829.1 - 0.27 11.1 1.5 0.99 9.3 0.2 2.3 2 0 0 2 2 2 0 DASH complex subunit Dam1 ABC_tran_CTD PF16326.5 KOG97829.1 - 0.3 11.3 0.2 0.3 11.3 0.2 2.5 1 1 1 2 2 2 0 ABC transporter C-terminal domain Seryl_tRNA_N PF02403.22 KOG97829.1 - 0.61 10.3 4.6 3.4 7.9 0.2 2.4 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.12 KOG97829.1 - 1.6 8.8 8.8 0.31 11.1 0.7 2.5 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein FapA PF03961.13 KOG97829.1 - 2.6 6.6 5.2 1.6 7.3 1.7 1.7 1 1 2 3 3 3 0 Flagellar Assembly Protein A Asp PF00026.23 KOG97830.1 - 4.5e-75 253.0 12.0 3.3e-65 220.6 5.2 2.3 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOG97830.1 - 2.9e-09 37.4 8.7 3.5e-05 24.1 0.1 3.0 3 1 0 3 3 3 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 KOG97830.1 - 0.065 13.0 0.0 1.3 8.8 0.0 2.3 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Asp PF00026.23 KOG97831.1 - 2.4e-70 237.5 2.5 4.1e-70 236.7 2.5 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOG97831.1 - 3.3e-07 30.7 4.0 3.3e-07 30.7 4.0 3.7 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 KOG97831.1 - 0.035 13.9 0.3 0.78 9.5 0.3 2.3 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal SPX PF03105.19 KOG97831.1 - 4.1 7.2 6.6 5.5 6.8 6.6 1.1 1 0 0 1 1 1 0 SPX domain RSF PF14876.6 KOG97832.1 - 0.0029 16.7 0.0 0.0029 16.6 0.0 1.2 1 0 0 1 1 1 1 Respiratory growth transcriptional regulator IpgD PF05925.12 KOG97832.1 - 0.12 10.9 0.8 0.15 10.6 0.8 1.0 1 0 0 1 1 1 0 Enterobacterial virulence protein IpgD DUF4400 PF14348.6 KOG97832.1 - 0.18 11.3 1.1 0.2 11.1 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) KfrA_N PF11740.8 KOG97832.1 - 0.93 10.2 8.8 1.3 9.8 8.8 1.1 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term NOA36 PF06524.12 KOG97832.1 - 1.8 7.9 8.0 2.1 7.6 8.0 1.0 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 KOG97832.1 - 4.5 5.9 6.1 5.2 5.7 6.1 1.0 1 0 0 1 1 1 0 Presenilin GATase PF00117.28 KOG97833.1 - 7.9e-14 51.9 0.0 9.7e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 KOG97833.1 - 0.028 14.2 0.1 0.25 11.0 0.1 2.1 1 1 0 1 1 1 0 Peptidase C26 ANAPC2 PF08672.11 KOG97834.1 - 6.9e-18 64.9 0.5 4.4e-17 62.3 0.1 2.5 2 0 0 2 2 2 1 Anaphase promoting complex (APC) subunit 2 Cullin PF00888.22 KOG97834.1 - 2.4e-13 49.6 0.7 2.4e-13 49.6 0.7 2.2 2 1 1 3 3 3 1 Cullin family FeoC PF09012.10 KOG97834.1 - 0.036 14.1 0.0 0.14 12.2 0.0 1.9 2 0 0 2 2 2 0 FeoC like transcriptional regulator DUF2274 PF10038.9 KOG97834.1 - 0.083 13.3 0.0 0.23 11.9 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2274) Cullin_binding PF03556.15 KOG97835.1 - 4.7e-30 104.5 4.9 5.5e-30 104.3 3.7 1.7 2 0 0 2 2 2 1 Cullin binding UBA_4 PF14555.6 KOG97835.1 - 4.1e-11 42.5 0.0 3.9e-10 39.4 0.0 2.3 2 0 0 2 2 2 1 UBA-like domain TAP_C PF03943.13 KOG97835.1 - 0.0046 16.6 0.0 0.011 15.4 0.0 1.7 1 0 0 1 1 1 1 TAP C-terminal domain WD40 PF00400.32 KOG97836.1 - 2.3e-49 164.3 33.1 9.5e-08 32.6 0.3 10.7 10 0 0 10 10 10 10 WD domain, G-beta repeat Utp12 PF04003.12 KOG97836.1 - 6.6e-18 65.0 0.5 1.2e-17 64.1 0.5 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 KOG97836.1 - 2.3e-16 59.8 15.4 0.0029 17.9 0.0 9.0 4 3 5 11 11 11 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOG97836.1 - 1.3e-09 37.2 7.9 0.0072 15.0 0.1 5.1 4 2 0 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 KOG97836.1 - 3.3e-07 29.9 7.5 0.00056 19.3 0.1 5.0 5 1 0 5 5 5 2 WD40-like domain Ge1_WD40 PF16529.5 KOG97836.1 - 0.00012 21.1 7.3 8.2 5.3 0.0 6.8 2 2 4 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Hira PF07569.11 KOG97836.1 - 0.00018 21.3 6.3 0.99 9.1 0.0 5.4 5 1 1 6 6 6 2 TUP1-like enhancer of split eIF2A PF08662.11 KOG97836.1 - 0.00031 20.7 2.5 0.18 11.6 0.0 4.5 2 2 2 5 5 5 1 Eukaryotic translation initiation factor eIF2A Cas_Csy4 PF09618.10 KOG97836.1 - 0.036 14.2 0.2 0.072 13.2 0.2 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) ELYS-bb PF16687.5 KOG97836.1 - 0.051 12.2 0.0 1.1 7.7 0.0 2.5 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin Zip PF02535.22 KOG97837.1 - 1.1e-87 294.4 1.8 1.7e-87 293.8 1.8 1.3 1 1 0 1 1 1 1 ZIP Zinc transporter UNC-50 PF05216.13 KOG97837.1 - 0.003 17.2 2.0 0.017 14.7 0.6 2.2 2 0 0 2 2 2 1 UNC-50 family zf-C2H2 PF00096.26 KOG97838.1 - 9.6e-08 32.1 10.7 0.001 19.4 1.3 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG97838.1 - 0.0028 18.3 8.5 0.19 12.6 0.8 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOG97838.1 - 0.0076 16.2 3.4 0.35 10.9 0.0 3.4 3 0 0 3 3 3 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOG97838.1 - 0.26 11.8 13.0 1.2 9.7 0.0 4.1 4 0 0 4 4 4 0 Zinc-finger double domain UPF0242 PF06785.11 KOG97838.1 - 6.2 6.9 13.3 12 6.0 13.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HVSL PF09749.9 KOG97839.1 - 1.4e-25 90.1 0.1 1.9e-25 89.7 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein AF-4 PF05110.13 KOG97839.1 - 0.13 10.4 2.2 0.14 10.2 2.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Choline_kinase PF01633.20 KOG97840.1 - 4e-72 242.2 0.2 5.5e-72 241.8 0.2 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 KOG97840.1 - 1.5e-15 56.6 0.6 3.5e-15 55.4 0.2 1.8 2 0 0 2 2 2 1 Choline kinase N terminus APH PF01636.23 KOG97840.1 - 3.5e-07 30.4 0.3 0.00021 21.3 0.0 2.4 2 1 0 2 2 2 2 Phosphotransferase enzyme family TPP_enzyme_N PF02776.18 KOG97841.1 - 2.6e-31 108.5 0.0 4.6e-31 107.7 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 KOG97841.1 - 3.7e-28 98.0 0.0 2.1e-27 95.5 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 KOG97841.1 - 9.4e-16 58.0 0.0 1.9e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.16 KOG97841.1 - 0.00049 19.9 0.3 0.0013 18.6 0.1 1.8 2 0 0 2 2 2 1 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit OCC1 PF15506.6 KOG97841.1 - 0.17 12.1 0.5 3.9 7.7 0.1 2.5 2 0 0 2 2 2 0 OCC1 family Slx4 PF09494.10 KOG97842.1 - 4.4e-16 58.6 0.4 2.1e-15 56.4 0.1 2.3 2 0 0 2 2 2 1 Slx4 endonuclease CCDC74_C PF14917.6 KOG97842.1 - 0.63 10.6 6.0 0.49 10.9 2.0 2.7 2 1 0 2 2 2 0 Coiled coil protein 74, C terminal zf-CCCH PF00642.24 KOG97843.1 - 3.2e-16 58.8 21.6 1.8e-09 37.3 1.5 3.0 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOG97843.1 - 6.9e-06 25.9 1.4 6.9e-06 25.9 1.4 3.1 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_4 PF18044.1 KOG97843.1 - 0.00027 20.7 15.9 0.00051 19.8 0.5 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 KOG97843.1 - 0.027 15.2 1.7 0.027 15.2 1.7 2.9 2 1 1 3 3 3 0 Torus domain Defensin_int PF17858.1 KOG97843.1 - 0.077 13.0 8.8 0.42 10.6 1.5 2.7 2 1 0 2 2 2 0 Platypus intermediate defensin-like peptide zf-CCCH_2 PF14608.6 KOG97843.1 - 6 7.5 16.0 0.29 11.7 0.7 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Methyltransf_16 PF10294.9 KOG97844.1 - 1.4e-05 24.9 0.0 0.042 13.6 0.0 2.3 2 0 0 2 2 2 2 Lysine methyltransferase Na_H_Exchanger PF00999.21 KOG97845.1 - 3.6e-91 305.8 26.7 4.3e-91 305.5 26.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Nha1_C PF08619.10 KOG97845.1 - 6.2e-79 266.4 47.6 6e-70 236.8 35.2 2.1 1 1 1 2 2 2 2 Alkali metal cation/H+ antiporter Nha1 C terminus MarC PF01914.17 KOG97845.1 - 0.13 11.7 2.5 6.2 6.1 0.7 2.5 2 0 0 2 2 2 0 MarC family integral membrane protein DUF4702 PF15774.5 KOG97845.1 - 0.4 9.6 2.9 0.2 10.6 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4702) SLS PF14611.6 KOG97846.1 - 2.1e-34 119.3 0.5 4.6e-34 118.2 0.5 1.6 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator GP46 PF07409.12 KOG97846.1 - 0.059 13.1 0.2 12 5.7 0.0 2.4 2 0 0 2 2 2 0 Phage protein GP46 Pro_dh PF01619.18 KOG97848.1 - 8e-61 206.1 0.0 9.9e-61 205.8 0.0 1.0 1 0 0 1 1 1 1 Proline dehydrogenase Diphthami_syn_2 PF01902.17 KOG97849.1 - 2.3e-35 122.1 0.2 2.4e-34 118.7 0.0 2.7 2 1 0 2 2 2 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 KOG97849.1 - 1.3e-18 67.1 0.0 2.6e-10 40.3 0.0 2.4 2 0 0 2 2 2 2 Endoribonuclease L-PSP THF_DHG_CYH PF00763.23 KOG97849.1 - 0.0056 16.9 0.1 0.021 15.1 0.0 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Glyco_hydro81C PF17652.1 KOG97851.1 - 5.8e-147 489.5 7.7 8.1e-147 489.0 7.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 KOG97851.1 - 3.2e-95 319.0 0.4 5.9e-95 318.1 0.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain HisKA_7TM PF16927.5 KOG97851.1 - 0.051 13.6 0.0 0.086 12.9 0.0 1.3 1 0 0 1 1 1 0 N-terminal 7TM region of histidine kinase Spermine_synth PF01564.17 KOG97853.1 - 9e-71 237.2 0.0 2.6e-70 235.7 0.0 1.7 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 KOG97853.1 - 6.6e-24 83.6 0.0 1.1e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_31 PF13847.6 KOG97853.1 - 2.9e-05 23.9 0.0 4e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOG97853.1 - 0.00016 21.5 0.0 0.00054 19.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOG97853.1 - 0.0007 20.3 0.0 0.0017 19.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 KOG97853.1 - 0.0061 15.8 0.0 0.0086 15.3 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_25 PF13649.6 KOG97853.1 - 0.009 16.7 0.0 0.019 15.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOG97853.1 - 0.075 12.3 0.0 0.26 10.6 0.0 1.8 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.14 KOG97853.1 - 0.15 11.6 0.0 0.37 10.3 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain DUF5071 PF16804.5 KOG97854.1 - 0.042 14.1 0.0 0.044 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5071) Eno-Rase_FAD_bd PF07055.12 KOG97854.1 - 0.074 13.5 0.6 0.09 13.2 0.6 1.2 1 0 0 1 1 1 0 Enoyl reductase FAD binding domain LSM PF01423.22 KOG97855.1 - 5.9e-16 57.9 0.0 7.2e-16 57.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KOG97855.1 - 0.047 13.8 0.1 0.078 13.1 0.1 1.4 2 0 0 2 2 2 0 Ataxin 2 SM domain Pep3_Vps18 PF05131.14 KOG97856.1 - 2.5e-40 137.7 0.1 6.3e-40 136.4 0.1 1.7 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 KOG97856.1 - 9.7e-17 61.2 7.1 9.7e-17 61.2 7.1 4.3 5 0 0 5 5 5 2 Region in Clathrin and VPS Vps39_2 PF10367.9 KOG97856.1 - 4.5e-05 23.9 2.4 7.6e-05 23.1 0.2 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.6 KOG97856.1 - 0.0063 16.4 2.7 0.014 15.4 2.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOG97856.1 - 0.0069 16.4 1.8 0.015 15.3 1.8 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 KOG97856.1 - 0.0078 15.9 3.0 0.018 14.7 3.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger Herpes_UL92 PF03048.14 KOG97856.1 - 0.017 14.9 0.4 0.086 12.6 0.4 2.2 1 0 0 1 1 1 0 UL92 family zf-RING_2 PF13639.6 KOG97856.1 - 0.02 15.2 3.8 0.02 15.2 3.8 1.8 2 0 0 2 2 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 KOG97856.1 - 0.11 12.4 2.8 0.29 11.0 2.8 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) YhdB PF14148.6 KOG97856.1 - 0.57 10.3 0.0 0.57 10.3 0.0 3.3 3 0 0 3 3 2 0 YhdB-like protein zf-C3HC4 PF00097.25 KOG97856.1 - 0.79 9.6 2.8 2.1 8.3 2.8 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 KOG97856.1 - 1.3 9.1 3.9 2.6 8.2 3.9 1.5 1 0 0 1 1 1 0 Zinc-finger DUF2415 PF10313.9 KOG97857.1 - 2.1e-20 72.4 1.3 4.3e-20 71.4 1.3 1.6 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) POLO_box PF00659.18 KOG97857.1 - 0.3 11.3 3.8 6 7.2 0.3 3.3 3 0 0 3 3 3 0 POLO box duplicated region Stm1_N PF09598.10 KOG97858.1 - 3.1e-08 34.4 4.8 3.1e-08 34.4 4.8 4.1 1 1 1 3 3 3 1 Stm1 NUDIX PF00293.28 KOG97859.1 - 6.9e-16 58.5 0.0 1.1e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Mem_trans PF03547.18 KOG97860.1 - 6e-25 87.4 7.2 3.6e-24 84.9 7.2 2.0 1 1 0 1 1 1 1 Membrane transport protein TcpE PF12648.7 KOG97860.1 - 0.048 14.2 0.0 0.048 14.2 0.0 4.2 3 2 2 5 5 5 0 TcpE family AMP-binding PF00501.28 KOG97861.1 - 7.1e-84 281.8 0.0 9.5e-84 281.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOG97861.1 - 1.3e-23 83.7 0.0 3.3e-23 82.5 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 KOG97861.1 - 4.8e-21 74.4 0.6 1.2e-20 73.1 0.6 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus DLL_N PF12413.8 KOG97861.1 - 4.6 8.6 5.8 1.1 10.5 1.7 2.1 2 0 0 2 2 2 0 Homeobox protein distal-less-like N terminal NTP_transf_2 PF01909.23 KOG97863.1 - 0.052 13.9 0.5 0.19 12.1 0.5 2.0 1 0 0 1 1 1 0 Nucleotidyltransferase domain Peptidase_M16 PF00675.20 KOG97864.1 - 2.4e-51 173.6 0.0 4.2e-51 172.8 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KOG97864.1 - 2.7e-37 128.6 0.0 2e-36 125.7 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain M16C_assoc PF08367.11 KOG97864.1 - 0.029 13.5 0.1 0.051 12.7 0.1 1.3 1 0 0 1 1 1 0 Peptidase M16C associated CybS PF05328.12 KOG97865.1 - 4.9e-48 162.2 0.0 5.8e-48 162.0 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit PseudoU_synth_2 PF00849.22 KOG97866.1 - 7.6e-23 81.4 0.3 1.1e-22 80.9 0.3 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase STATa_Ig PF18214.1 KOG97866.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 STATa Immunoglobulin-like domain Sec10 PF07393.11 KOG97867.1 - 4.2e-207 689.9 31.2 5.5e-207 689.5 31.2 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 RTBV_P12 PF06361.11 KOG97867.1 - 0.0089 16.4 2.1 0.018 15.4 0.5 2.3 2 1 1 3 3 3 1 Rice tungro bacilliform virus P12 protein DUF4473 PF14747.6 KOG97867.1 - 0.084 13.4 0.4 0.97 10.0 0.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4473) FAM184 PF15665.5 KOG97867.1 - 0.73 9.6 7.9 0.17 11.7 3.1 2.3 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B ubiquitin PF00240.23 KOG97868.1 - 4.5e-34 116.0 0.6 7.7e-34 115.3 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 KOG97868.1 - 1.6e-24 85.8 2.3 3.9e-24 84.6 2.3 1.7 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.8 KOG97868.1 - 2.3e-16 59.4 0.9 4.7e-16 58.4 0.7 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KOG97868.1 - 2.4e-05 24.7 0.1 0.00012 22.4 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 KOG97868.1 - 0.0014 18.7 0.4 0.0031 17.6 0.4 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 KOG97868.1 - 0.0036 17.6 0.3 0.0076 16.6 0.1 1.6 1 1 1 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 KOG97868.1 - 0.0052 16.7 0.0 0.008 16.1 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 KOG97868.1 - 0.016 15.8 0.5 0.021 15.4 0.5 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 KOG97868.1 - 0.02 15.0 1.0 5.7 7.1 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain IBR PF01485.21 KOG97868.1 - 0.02 15.1 0.2 0.037 14.3 0.2 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Fer2_3 PF13085.6 KOG97868.1 - 0.087 12.8 0.2 0.15 12.1 0.2 1.5 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain PRELI PF04707.14 KOG97869.1 - 2.9e-61 205.9 0.7 3.9e-61 205.5 0.7 1.2 1 0 0 1 1 1 1 PRELI-like family GalP_UDP_tr_C PF02744.17 KOG97869.1 - 0.0097 15.6 0.1 0.022 14.5 0.1 1.6 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain Clat_adaptor_s PF01217.20 KOG97870.1 - 4.2e-59 198.6 2.9 4.8e-59 198.4 2.9 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF5618 PF18498.1 KOG97870.1 - 0.093 12.9 0.1 0.13 12.4 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF5618) TP_methylase PF00590.20 KOG97871.1 - 2.2e-26 93.1 0.0 3.2e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF4434 PF14488.6 KOG97871.1 - 0.084 12.9 0.1 0.21 11.6 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4434) Iso_dh PF00180.20 KOG97873.1 - 2e-71 241.0 0.0 2.3e-71 240.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase YfmQ PF10787.9 KOG97873.1 - 0.086 12.6 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein from bacillus cereus group DUF4355 PF14265.6 KOG97873.1 - 0.26 11.5 1.4 0.39 11.0 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) DKCLD PF08068.12 KOG97874.1 - 1.7e-32 111.3 0.2 2e-31 107.8 0.3 2.4 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 KOG97874.1 - 4.2e-23 81.3 0.3 8.6e-23 80.3 0.3 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 KOG97874.1 - 1.5e-20 74.1 6.8 2.4e-19 70.2 0.1 3.8 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 KOG97874.1 - 3.1e-19 68.7 1.0 6.3e-19 67.7 1.0 1.6 1 0 0 1 1 1 1 PUA domain CDC27 PF09507.10 KOG97874.1 - 0.0024 17.4 32.1 0.0029 17.0 32.1 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 UPF0113 PF03657.13 KOG97874.1 - 0.028 14.7 0.0 0.078 13.2 0.0 1.8 1 0 0 1 1 1 0 UPF0113 PUA domain GAGA_bind PF06217.12 KOG97874.1 - 0.27 11.5 22.1 0.37 11.0 22.1 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family EOS1 PF12326.8 KOG97874.1 - 3.4 7.6 4.5 5.4 6.9 4.5 1.4 1 0 0 1 1 1 0 N-glycosylation protein RFX_DNA_binding PF02257.15 KOG97875.1 - 1.9e-33 114.9 0.5 1.6e-32 111.9 0.1 2.7 3 0 0 3 3 3 1 RFX DNA-binding domain Pox_D5 PF03288.16 KOG97875.1 - 0.0065 16.9 0.0 0.018 15.5 0.0 1.7 1 0 0 1 1 1 1 Poxvirus D5 protein-like Cdc6_C PF09079.11 KOG97875.1 - 0.0095 15.9 0.0 0.054 13.5 0.0 2.2 2 0 0 2 2 2 1 CDC6, C terminal winged helix domain Ntox50 PF15542.6 KOG97875.1 - 0.94 10.3 4.2 5.3 7.9 0.0 2.6 2 0 0 2 2 2 0 Bacterial toxin 50 PSP1 PF04468.12 KOG97876.1 - 1.2e-42 144.1 1.1 2.6e-42 143.0 1.1 1.7 1 0 0 1 1 1 1 PSP1 C-terminal conserved region PBP PF01161.20 KOG97877.1 - 1.6e-22 80.3 0.3 2e-22 79.9 0.3 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PBP PF01161.20 KOG97878.1 - 4.4e-18 65.9 0.0 5.4e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF4320 PF14208.6 KOG97878.1 - 0.19 11.8 0.0 0.36 10.9 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4320) S-AdoMet_synt_C PF02773.16 KOG97879.1 - 2.9e-64 215.2 0.0 4.9e-64 214.5 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 KOG97879.1 - 1e-45 154.4 0.2 1e-45 154.4 0.2 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 KOG97879.1 - 1.5e-45 154.3 0.0 3.3e-45 153.2 0.0 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain AdoMet_Synthase PF01941.19 KOG97879.1 - 0.037 12.8 0.4 0.17 10.6 0.2 1.9 2 0 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) Vta1 PF04652.16 KOG97880.1 - 3.2e-36 124.5 0.2 3.2e-36 124.5 0.2 2.0 3 0 0 3 3 3 1 Vta1 like Vta1_C PF18097.1 KOG97880.1 - 5e-15 54.9 1.0 1.1e-14 53.8 1.0 1.6 1 0 0 1 1 1 1 Vta1 C-terminal domain DUF4041 PF13250.6 KOG97880.1 - 0.012 15.5 3.2 2.7 7.9 0.0 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4041) Swi6_N PF18530.1 KOG97881.1 - 2.9e-36 123.9 0.1 2.9e-36 123.9 0.1 3.2 2 1 0 2 2 2 1 Swi6 N-terminal domain Ank_2 PF12796.7 KOG97881.1 - 6.3e-10 39.5 0.7 0.0021 18.6 0.0 3.1 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOG97881.1 - 7.4e-10 38.9 1.0 1.5e-05 25.2 0.1 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOG97881.1 - 5.9e-09 35.4 2.1 0.00039 20.6 0.1 3.4 3 0 0 3 3 2 2 Ankyrin repeat Ank PF00023.30 KOG97881.1 - 1.6e-08 34.6 1.8 0.0061 17.0 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 KOG97881.1 - 5.1e-06 26.9 0.7 0.012 16.2 0.0 4.1 3 1 1 4 4 4 2 Ankyrin repeats (many copies) DUF3375 PF11855.8 KOG97881.1 - 0.0028 16.6 1.2 0.0069 15.4 1.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3375) Phage_GPO PF05929.11 KOG97881.1 - 0.0037 16.9 6.5 0.0037 16.9 6.5 2.5 2 0 0 2 2 2 1 Phage capsid scaffolding protein (GPO) serine peptidase FAP206 PF12018.8 KOG97881.1 - 0.16 11.5 10.9 0.51 9.8 4.0 2.5 2 0 0 2 2 2 0 Domain of unknown function ATP-cone PF03477.16 KOG97881.1 - 0.47 11.1 12.9 1.4 9.6 0.1 4.4 5 0 0 5 5 5 0 ATP cone domain DUF489 PF04356.12 KOG97881.1 - 2.7 8.0 5.8 1.3 9.0 2.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF489) COG5 PF10392.9 KOG97881.1 - 8.2 6.6 19.3 1.5 9.0 6.3 4.0 4 0 0 4 4 4 0 Golgi transport complex subunit 5 FHA PF00498.26 KOG97882.1 - 4.9e-05 23.6 0.1 0.00015 22.0 0.1 1.9 1 0 0 1 1 1 1 FHA domain Ribosomal_L37e PF01907.19 KOG97883.1 - 1.4e-27 95.6 10.8 2.4e-27 94.8 10.8 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e SelR PF01641.18 KOG97883.1 - 0.002 18.2 0.6 0.0025 17.9 0.6 1.3 1 0 0 1 1 1 1 SelR domain DZR PF12773.7 KOG97883.1 - 0.0066 16.5 1.6 0.0093 16.0 1.6 1.2 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_6 PF14599.6 KOG97883.1 - 0.045 13.8 1.9 0.075 13.1 1.9 1.3 1 0 0 1 1 1 0 Zinc-ribbon zf-RING_5 PF14634.6 KOG97883.1 - 0.058 13.4 3.1 0.089 12.8 3.1 1.3 1 0 0 1 1 1 0 zinc-RING finger domain HypA PF01155.19 KOG97883.1 - 0.12 12.4 1.5 0.17 11.9 1.5 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_2 PF13240.6 KOG97883.1 - 0.23 11.2 4.3 6.6 6.6 0.7 2.2 2 0 0 2 2 2 0 zinc-ribbon domain DUF1258 PF06869.12 KOG97883.1 - 0.26 10.7 4.8 0.16 11.4 3.2 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1258) zf-Mss51 PF13824.6 KOG97883.1 - 0.3 11.2 3.5 1.1 9.4 3.5 1.9 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-ribbon_3 PF13248.6 KOG97883.1 - 0.34 10.4 3.6 1 8.9 3.6 1.7 1 1 0 1 1 1 0 zinc-ribbon domain EMG1 PF03587.14 KOG97884.1 - 1.8e-77 259.4 0.0 2.1e-77 259.2 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase PH PF00169.29 KOG97885.1 - 5.4e-09 36.5 0.6 7.5e-07 29.6 0.1 2.6 2 0 0 2 2 2 2 PH domain ABC_membrane PF00664.23 KOG97886.1 - 1.1e-63 215.5 3.0 1.4e-63 215.2 3.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KOG97886.1 - 9.3e-31 107.2 0.0 2.6e-30 105.7 0.0 1.8 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KOG97886.1 - 1.1e-05 25.0 2.2 0.00029 20.3 0.5 2.5 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 KOG97886.1 - 0.00079 19.7 0.2 0.013 15.8 0.2 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOG97886.1 - 0.0014 19.1 0.1 0.0059 17.0 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain PrgI PF12666.7 KOG97886.1 - 0.0068 17.1 2.0 0.44 11.3 0.0 3.0 3 0 0 3 3 3 1 PrgI family protein AAA PF00004.29 KOG97886.1 - 0.01 16.3 0.0 0.21 12.0 0.0 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 KOG97886.1 - 0.011 15.5 0.0 0.027 14.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 KOG97886.1 - 0.013 15.2 0.0 2.2 8.0 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_21 PF13304.6 KOG97886.1 - 0.02 14.7 0.1 0.2 11.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 KOG97886.1 - 0.032 14.2 0.0 0.45 10.5 0.0 2.7 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KOG97886.1 - 0.042 13.4 0.0 0.08 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 KOG97886.1 - 0.056 13.6 0.0 0.4 10.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 KOG97886.1 - 0.059 13.9 0.0 1.1 9.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 KOG97886.1 - 0.081 12.7 0.0 0.39 10.5 0.0 1.9 1 1 0 1 1 1 0 DEAD/DEAH box helicase Zeta_toxin PF06414.12 KOG97886.1 - 0.082 12.2 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin SbcCD_C PF13558.6 KOG97886.1 - 0.17 12.1 0.7 1.7 8.9 0.7 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Glyco_transf_28 PF03033.20 KOG97887.1 - 3.5e-35 121.0 0.0 9.1e-35 119.7 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain GRAM PF02893.20 KOG97887.1 - 3.9e-31 107.3 0.6 1e-25 89.9 0.2 3.2 2 0 0 2 2 2 2 GRAM domain UDPGT PF00201.18 KOG97887.1 - 2.4e-10 39.8 0.0 6.7e-10 38.4 0.0 1.7 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase PH PF00169.29 KOG97887.1 - 1.7e-09 38.1 4.1 4.7e-09 36.7 1.2 2.7 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 KOG97887.1 - 0.012 16.1 0.9 0.012 16.1 0.9 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain PH_2 PF08458.10 KOG97887.1 - 0.016 15.5 0.1 0.048 14.0 0.1 1.8 1 0 0 1 1 1 0 Plant pleckstrin homology-like region MMR1 PF08505.10 KOG97888.1 - 6.6e-65 220.0 16.5 6.6e-65 220.0 16.5 3.2 2 1 0 2 2 2 1 Mitochondrial Myo2 receptor-related protein LCIB_C_CA PF18599.1 KOG97888.1 - 0.027 13.8 0.4 0.057 12.7 0.4 1.5 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases Med9 PF07544.13 KOG97888.1 - 0.041 14.0 0.3 0.041 14.0 0.3 3.6 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 YlqD PF11068.8 KOG97888.1 - 3.2 8.1 16.0 4.3 7.7 4.8 2.4 2 0 0 2 2 2 0 YlqD protein DUF573 PF04504.14 KOG97888.1 - 4.2 8.1 11.1 8.5 7.1 2.3 2.9 2 1 0 2 2 2 0 Protein of unknown function, DUF573 Peroxin-13_N PF04088.13 KOG97889.1 - 4e-51 173.1 0.3 4e-51 173.1 0.3 1.6 2 0 0 2 2 2 1 Peroxin 13, N-terminal region SH3_1 PF00018.28 KOG97889.1 - 5.1e-09 35.6 0.1 9.4e-09 34.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KOG97889.1 - 5.7e-07 29.1 0.3 1.1e-06 28.2 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 KOG97889.1 - 8.8e-07 28.7 0.0 1.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 KOG97889.1 - 0.0054 17.0 0.1 0.0094 16.2 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain GET2 PF08690.10 KOG97889.1 - 2.8 7.5 4.5 5.7 6.5 4.5 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 eIF3_subunit PF08597.10 KOG97890.1 - 4e-51 174.3 19.4 1.1e-50 172.9 19.4 1.6 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit PRELI PF04707.14 KOG97891.1 - 6.2e-51 172.3 0.0 7.2e-51 172.1 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family NMT_C PF02799.15 KOG97893.1 - 3.1e-79 265.3 0.1 5e-79 264.7 0.1 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 KOG97893.1 - 6.2e-74 247.2 0.0 1.1e-73 246.3 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 KOG97893.1 - 8.8e-07 29.0 0.0 0.00016 21.8 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOG97893.1 - 0.05 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family WD40 PF00400.32 KOG97894.1 - 6.9e-06 26.7 10.3 0.015 16.1 0.7 5.7 6 0 0 6 6 6 2 WD domain, G-beta repeat Nup160 PF11715.8 KOG97894.1 - 7e-06 25.0 3.8 9.1e-05 21.3 2.3 2.2 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 KOG97894.1 - 0.0023 16.8 1.7 0.016 14.0 0.1 2.1 1 1 0 2 2 2 1 Nup133 N terminal like SUKH_6 PF14568.6 KOG97894.1 - 0.013 15.9 3.3 0.024 15.1 0.0 2.9 3 0 0 3 3 3 0 SMI1-KNR4 cell-wall PQQ_3 PF13570.6 KOG97894.1 - 0.055 14.0 0.7 0.54 10.8 0.0 3.0 5 0 0 5 5 5 0 PQQ-like domain WD40_like PF17005.5 KOG97894.1 - 0.12 11.6 0.0 0.27 10.5 0.0 1.5 1 0 0 1 1 1 0 WD40-like domain Nop PF01798.18 KOG97895.1 - 5e-84 281.4 0.1 5e-84 281.4 0.1 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 KOG97895.1 - 6.7e-20 71.2 0.4 6.7e-20 71.2 0.4 2.6 2 1 0 2 2 2 1 NOP5NT (NUC127) domain GAGA_bind PF06217.12 KOG97895.1 - 0.27 11.5 17.3 0.43 10.8 17.3 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family RR_TM4-6 PF06459.12 KOG97895.1 - 1.3 8.8 27.1 2.1 8.1 27.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNA_polI_A34 PF08208.11 KOG97895.1 - 6.6 6.8 51.4 11 6.1 51.4 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 CDC45 PF02724.14 KOG97895.1 - 9.3 4.4 26.0 13 3.9 26.0 1.2 1 0 0 1 1 1 0 CDC45-like protein POC1 PF10450.9 KOG97896.1 - 1.2e-102 342.6 0.2 1.3e-102 342.5 0.2 1.0 1 0 0 1 1 1 1 POC1 chaperone Prefoldin_2 PF01920.20 KOG97897.1 - 2.2e-24 85.5 10.9 2.3e-24 85.4 10.9 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF4201 PF13870.6 KOG97897.1 - 0.0051 16.6 6.0 0.052 13.3 0.8 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) Sec2p PF06428.11 KOG97897.1 - 0.0086 16.0 8.7 0.13 12.2 0.6 2.1 2 0 0 2 2 2 2 GDP/GTP exchange factor Sec2p UPF0242 PF06785.11 KOG97897.1 - 0.015 15.5 9.2 0.017 15.2 9.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Spc24 PF08286.11 KOG97897.1 - 0.017 15.4 7.4 0.77 10.0 0.8 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 PI3K_P85_iSH2 PF16454.5 KOG97897.1 - 0.078 12.6 6.4 0.22 11.1 1.0 2.1 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ATG16 PF08614.11 KOG97897.1 - 0.1 12.8 10.0 1.5 9.0 10.0 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) YnfE PF17452.2 KOG97897.1 - 0.11 12.8 1.1 12 6.3 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized YnfE-like Uso1_p115_C PF04871.13 KOG97897.1 - 0.16 12.4 8.6 0.24 11.8 1.0 2.1 1 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region eIF-4B PF06273.11 KOG97897.1 - 0.17 10.9 4.3 0.19 10.7 4.3 1.1 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B CENP-F_leu_zip PF10473.9 KOG97897.1 - 0.19 11.8 9.2 1.2 9.2 1.0 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NBP1 PF08537.10 KOG97897.1 - 0.23 10.8 4.6 0.28 10.6 4.6 1.0 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 Bcr-Abl_Oligo PF09036.10 KOG97897.1 - 0.29 11.2 4.6 0.37 10.8 0.5 2.2 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain DUF5082 PF16888.5 KOG97897.1 - 0.31 11.3 6.0 0.97 9.7 6.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DUF641 PF04859.12 KOG97897.1 - 0.34 11.2 8.5 0.12 12.7 1.2 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FliJ PF02050.16 KOG97897.1 - 0.38 11.0 8.4 4.1 7.7 0.6 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein GAS PF13851.6 KOG97897.1 - 0.38 10.1 10.6 1.6 8.1 2.2 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Fib_alpha PF08702.10 KOG97897.1 - 0.41 10.8 6.0 2 8.6 5.9 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 KOG97897.1 - 0.43 11.0 9.0 0.25 11.8 1.1 2.5 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Fez1 PF06818.15 KOG97897.1 - 0.5 10.8 8.9 0.31 11.5 2.6 2.0 1 1 1 2 2 2 0 Fez1 Jnk-SapK_ap_N PF09744.9 KOG97897.1 - 0.78 9.9 13.0 14 5.9 13.0 2.0 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF1192 PF06698.11 KOG97897.1 - 0.8 9.8 5.7 0.2 11.8 1.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) YojJ PF10372.9 KOG97897.1 - 1 9.5 4.6 0.59 10.3 0.3 2.3 2 1 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus DMPK_coil PF08826.10 KOG97897.1 - 1.2 9.4 12.7 0.67 10.1 3.9 2.6 2 2 0 2 2 2 0 DMPK coiled coil domain like Tropomyosin_1 PF12718.7 KOG97897.1 - 1.8 8.7 11.4 6.7 6.9 11.4 1.9 1 1 0 1 1 1 0 Tropomyosin like Occludin_ELL PF07303.13 KOG97897.1 - 2.2 9.1 6.5 87 3.9 6.5 2.1 1 1 0 1 1 1 0 Occludin homology domain ABC_tran_CTD PF16326.5 KOG97897.1 - 2.9 8.2 10.8 2.2 8.6 1.5 2.9 2 1 0 2 2 2 0 ABC transporter C-terminal domain APG6_N PF17675.1 KOG97897.1 - 3.6 8.1 13.0 40 4.8 13.0 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region Swi5 PF07061.11 KOG97897.1 - 3.7 7.7 7.9 9.4 6.4 1.5 2.2 2 0 0 2 2 2 0 Swi5 COQ9 PF08511.11 KOG97898.1 - 4.6e-22 77.6 1.7 1e-21 76.4 0.7 1.9 2 0 0 2 2 2 1 COQ9 DUF1447 PF07288.11 KOG97898.1 - 0.098 12.7 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1447) zf-Mss51 PF13824.6 KOG97899.1 - 1.9e-16 59.9 1.0 3.8e-16 58.9 1.0 1.5 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 YL1_C PF08265.11 KOG97899.1 - 0.02 14.6 0.6 0.055 13.2 0.6 1.8 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain DUF1713 PF08213.11 KOG97900.1 - 8.6e-12 44.8 24.3 1.2e-11 44.3 24.3 1.2 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) SR-25 PF10500.9 KOG97900.1 - 0.00069 19.3 3.8 0.00069 19.3 3.8 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein FAM199X PF15814.5 KOG97900.1 - 0.022 13.8 1.5 0.023 13.8 1.5 1.0 1 0 0 1 1 1 0 Protein family FAM199X Heme_oxygenase PF01126.20 KOG97901.1 - 1.4e-11 44.6 0.2 4.1e-11 43.1 0.2 1.8 1 1 0 1 1 1 1 Heme oxygenase ENTH PF01417.20 KOG97902.1 - 1.4e-41 141.4 0.3 4.9e-41 139.7 0.0 2.2 2 0 0 2 2 2 1 ENTH domain Sel1 PF08238.12 KOG97903.1 - 1.2e-19 70.3 4.2 0.00021 21.9 0.0 8.1 8 0 0 8 8 8 2 Sel1 repeat TPR_1 PF00515.28 KOG97903.1 - 6.6e-06 25.7 10.7 0.27 11.1 0.4 5.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOG97903.1 - 1.8e-05 24.5 9.8 0.36 11.1 0.5 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOG97903.1 - 3e-05 24.2 0.8 0.59 10.5 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOG97903.1 - 8.1e-05 22.4 9.0 0.11 12.6 0.1 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOG97903.1 - 0.00096 19.2 5.3 1.2 9.5 0.1 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOG97903.1 - 0.0081 16.7 5.3 8.5 7.3 0.2 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat SURF2 PF05477.11 KOG97903.1 - 0.51 10.0 0.0 0.51 10.0 0.0 1.8 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) TPR_11 PF13414.6 KOG97903.1 - 0.78 9.5 7.9 0.068 12.9 0.8 2.8 3 0 0 3 3 3 0 TPR repeat TPR_19 PF14559.6 KOG97903.1 - 4.4 7.9 7.2 3.9 8.1 0.1 4.3 6 0 0 6 6 6 0 Tetratricopeptide repeat WD40 PF00400.32 KOG97904.1 - 2.2e-20 72.6 18.1 3e-05 24.7 0.6 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97904.1 - 1.3e-06 28.6 5.1 0.1 12.9 0.1 4.7 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOG97904.1 - 0.067 12.1 0.1 7.3 5.4 0.0 3.4 2 2 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PNP_UDP_1 PF01048.20 KOG97905.1 - 7.1e-43 146.5 0.0 8.6e-43 146.3 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Cyclin_N PF00134.23 KOG97906.1 - 3.1e-42 143.3 0.5 6.5e-42 142.3 0.5 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOG97906.1 - 1.3e-30 105.9 0.2 4e-30 104.4 0.0 1.9 2 0 0 2 2 2 1 Cyclin, C-terminal domain Rootletin PF15035.6 KOG97907.1 - 0.00038 20.5 3.5 0.00038 20.5 3.5 1.1 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion Spectrin PF00435.21 KOG97907.1 - 0.056 13.9 2.7 0.1 13.1 2.7 1.4 1 0 0 1 1 1 0 Spectrin repeat Uso1_p115_C PF04871.13 KOG97907.1 - 0.15 12.5 4.4 0.21 12.0 4.4 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region YabA PF06156.13 KOG97907.1 - 0.75 10.5 5.5 0.2 12.3 2.0 1.9 2 1 0 2 2 2 0 Initiation control protein YabA Tubulin PF00091.25 KOG97908.1 - 2e-65 220.7 0.0 3.3e-65 220.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOG97908.1 - 7.2e-31 107.0 0.7 1.1e-29 103.2 0.2 2.4 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 KOG97908.1 - 0.0011 19.2 0.0 0.0024 18.2 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 KOG97908.1 - 0.0043 16.8 0.0 0.012 15.3 0.0 1.8 2 0 0 2 2 2 1 Tubulin domain Tubulin_2 PF13809.6 KOG97908.1 - 0.031 13.5 0.0 0.05 12.8 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Glyco_hydro_16 PF00722.21 KOG97909.1 - 6e-48 162.6 0.1 1.1e-47 161.8 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 CFEM PF05730.11 KOG97910.1 - 0.0019 18.2 6.2 0.0031 17.6 6.2 1.3 1 0 0 1 1 1 1 CFEM domain CFEM PF05730.11 KOG97911.1 - 0.00031 20.8 6.0 0.0005 20.1 6.0 1.3 1 0 0 1 1 1 1 CFEM domain D123 PF07065.14 KOG97912.1 - 5.5e-109 364.0 3.0 5.5e-109 364.0 3.0 1.3 2 0 0 2 2 2 1 D123 R2K_3 PF14243.6 KOG97912.1 - 0.086 12.8 0.1 0.17 11.8 0.0 1.6 1 1 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 Pro_isomerase PF00160.21 KOG97913.1 - 2e-43 148.4 0.5 3.6e-43 147.6 0.1 1.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 KOG97913.1 - 3.7e-06 26.5 1.4 8.6e-05 22.2 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOG97913.1 - 0.00013 21.8 0.2 0.04 14.0 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOG97913.1 - 0.074 13.7 0.4 0.7 10.7 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOG97913.1 - 0.38 11.1 2.1 0.76 10.2 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat VIT1 PF01988.19 KOG97915.1 - 6.8e-62 209.1 0.2 8.3e-62 208.8 0.2 1.1 1 0 0 1 1 1 1 VIT family T3RM_EcoP15I_C PF18273.1 KOG97915.1 - 0.065 13.5 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 Type III R-M EcoP15I C-terminal domain CsgG PF03783.14 KOG97915.1 - 0.12 11.7 0.7 0.2 10.9 0.2 1.6 2 0 0 2 2 2 0 Curli production assembly/transport component CsgG Rsa3 PF14615.6 KOG97916.1 - 8.4e-19 66.9 0.2 1.7e-18 65.9 0.2 1.6 1 0 0 1 1 1 1 Ribosome-assembly protein 3 GEMIN8 PF15348.6 KOG97916.1 - 2.2 8.5 13.2 4.6 7.5 13.2 1.4 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 Pap_E4 PF02711.14 KOG97916.1 - 5.6 8.0 5.5 11 7.1 5.5 1.5 1 0 0 1 1 1 0 E4 protein Utp13 PF08625.11 KOG97917.1 - 3.3e-49 166.5 0.3 5.7e-49 165.7 0.3 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain WD40 PF00400.32 KOG97917.1 - 3.7e-45 151.0 18.1 2.5e-06 28.1 0.1 10.5 10 0 0 10 10 10 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG97917.1 - 1.6e-21 76.4 3.7 0.00064 20.0 0.1 7.2 5 2 2 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOG97917.1 - 9.1e-07 28.5 5.6 0.018 14.4 0.1 4.1 2 2 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 KOG97917.1 - 6.2e-06 25.1 5.4 2.4 6.7 0.2 5.7 2 2 2 5 5 5 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 KOG97917.1 - 0.0013 17.5 1.1 0.15 10.7 0.4 3.1 2 1 1 3 3 3 1 Nup133 N terminal like eIF2A PF08662.11 KOG97917.1 - 0.049 13.5 0.6 36 4.2 0.0 4.2 3 2 2 5 5 5 0 Eukaryotic translation initiation factor eIF2A Hira PF07569.11 KOG97917.1 - 0.095 12.4 0.1 1.3 8.7 0.0 2.9 2 0 0 2 2 2 0 TUP1-like enhancer of split CRF1 PF10380.9 KOG97918.1 - 6.2e-35 119.9 4.2 6.2e-35 119.9 4.2 5.7 5 3 0 5 5 5 1 Transcription factor CRF1 Svf1_C PF17187.4 KOG97920.1 - 1.5e-39 135.4 1.1 5.6e-39 133.6 1.1 1.9 1 1 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 KOG97920.1 - 9.7e-39 133.0 0.0 1.9e-38 132.1 0.0 1.5 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain DUF1623 PF07785.11 KOG97922.1 - 0.088 13.0 0.5 0.25 11.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1623) Fungal_trans_2 PF11951.8 KOG97923.1 - 3.9e-13 49.0 0.5 9.2e-13 47.7 0.5 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG97923.1 - 4.4e-08 33.1 11.9 6.7e-08 32.5 11.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DTW PF03942.15 KOG97923.1 - 0.23 11.2 3.1 0.73 9.5 3.1 2.0 1 1 0 1 1 1 0 DTW domain Ras PF00071.22 KOG97924.1 - 7.6e-51 171.9 0.0 8.8e-51 171.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG97924.1 - 1.8e-18 66.9 0.0 2.5e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG97924.1 - 7.2e-07 28.8 0.0 9.6e-07 28.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PET117 PF15786.5 KOG97924.1 - 0.16 12.2 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial Aminotran_5 PF00266.19 KOG97925.1 - 9.1e-11 41.3 0.0 2.2e-10 40.1 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V EST1_DNA_bind PF10373.9 KOG97926.1 - 2e-34 119.4 2.6 2e-34 119.4 2.6 2.0 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 KOG97926.1 - 1.4e-08 35.4 2.0 2.3e-08 34.8 0.2 2.3 2 0 0 2 2 2 1 Telomerase activating protein Est1 Nrap_D3 PF17404.2 KOG97926.1 - 0.099 12.7 0.6 0.19 11.8 0.6 1.5 1 0 0 1 1 1 0 Nrap protein domain 3 Topoisom_bac PF01131.20 KOG97927.1 - 1.8e-98 330.3 0.0 2.8e-98 329.6 0.0 1.3 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 KOG97927.1 - 2.7e-22 78.9 0.0 7.2e-22 77.6 0.0 1.8 1 0 0 1 1 1 1 Toprim domain Transp_cyt_pur PF02133.15 KOG97928.1 - 5e-69 233.2 40.2 6.9e-69 232.7 40.2 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin SPC25 PF06703.11 KOG97928.1 - 0.54 10.0 3.4 1.3 8.8 3.4 1.6 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) FHA PF00498.26 KOG97929.1 - 2.7e-19 69.3 0.6 1.3e-17 63.9 0.4 2.8 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 KOG97929.1 - 3.1e-05 24.2 0.0 0.00012 22.3 0.0 2.0 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain DUF3150 PF11348.8 KOG97929.1 - 0.055 12.7 2.3 0.095 11.9 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) Exonuc_VII_L PF02601.15 KOG97929.1 - 0.09 12.3 6.0 0.13 11.8 6.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit GCD14 PF08704.10 KOG97929.1 - 0.15 11.7 1.7 0.31 10.7 1.7 1.5 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit MS_channel PF00924.18 KOG97929.1 - 0.23 11.0 3.6 2.7 7.5 0.6 2.5 2 0 0 2 2 2 0 Mechanosensitive ion channel BPL_LplA_LipB PF03099.19 KOG97930.1 - 4.4e-26 91.3 0.2 7.6e-26 90.6 0.2 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family IclR PF01614.18 KOG97930.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial transcriptional regulator PI3Ka PF00613.20 KOG97931.1 - 5.6e-78 260.6 2.6 8.5e-78 260.0 2.6 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 KOG97931.1 - 8.1e-51 173.2 0.1 9.4e-48 163.2 0.0 2.7 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 KOG97931.1 - 1.9e-30 105.6 0.1 5.7e-30 104.1 0.1 1.9 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 AlcCBM31 PF11606.8 KOG97931.1 - 0.13 12.4 0.0 0.51 10.5 0.0 2.0 1 0 0 1 1 1 0 Family 31 carbohydrate binding protein RSN1_7TM PF02714.15 KOG97932.1 - 5.7e-81 271.8 27.5 5.7e-81 271.8 27.5 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 KOG97932.1 - 5.8e-43 146.3 1.3 5.8e-43 146.3 1.3 2.5 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 KOG97932.1 - 9.1e-33 113.9 0.0 1.4e-32 113.4 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Pox_EPC_I2-L1 PF12575.8 KOG97932.1 - 0.02 15.1 0.1 0.02 15.1 0.1 3.0 3 0 0 3 3 3 0 Poxvirus entry protein complex L1 and I2 Arv1 PF04161.13 KOG97933.1 - 5.2e-64 216.3 11.4 8.7e-64 215.5 11.4 1.3 1 0 0 1 1 1 1 Arv1-like family Prok-RING_4 PF14447.6 KOG97933.1 - 0.23 11.4 1.8 0.92 9.4 1.8 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 ATP_bind_1 PF03029.17 KOG97934.1 - 2.8e-89 299.1 0.0 3.2e-89 298.9 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 KOG97934.1 - 0.00072 18.6 0.1 0.0025 16.8 0.0 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 KOG97934.1 - 0.0016 18.3 0.0 0.0099 15.7 0.0 2.2 3 0 0 3 3 3 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_10 PF12846.7 KOG97934.1 - 0.0035 16.3 0.0 0.0054 15.7 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain RsgA_GTPase PF03193.16 KOG97934.1 - 0.0075 16.2 0.2 0.049 13.5 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase RNA_helicase PF00910.22 KOG97934.1 - 0.0077 16.6 0.0 0.03 14.7 0.0 2.1 2 0 0 2 2 1 1 RNA helicase MMR_HSR1 PF01926.23 KOG97934.1 - 0.0097 16.0 0.0 0.026 14.6 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 KOG97934.1 - 0.0097 16.4 0.0 0.022 15.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter KAP_NTPase PF07693.14 KOG97934.1 - 0.011 14.9 0.0 0.037 13.3 0.0 1.7 2 0 0 2 2 2 0 KAP family P-loop domain AAA_18 PF13238.6 KOG97934.1 - 0.015 15.8 0.1 0.2 12.2 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 KOG97934.1 - 0.016 15.0 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 KOG97934.1 - 0.024 14.1 0.0 0.037 13.5 0.0 1.2 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family DUF87 PF01935.17 KOG97934.1 - 0.031 14.4 0.0 0.058 13.5 0.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_29 PF13555.6 KOG97934.1 - 0.037 13.8 0.0 0.077 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_31 PF13614.6 KOG97934.1 - 0.038 13.9 0.0 1.1 9.1 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KOG97934.1 - 0.038 13.7 0.0 0.067 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOG97934.1 - 0.061 13.6 0.0 0.12 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 KOG97934.1 - 0.061 13.7 0.0 0.19 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 KOG97934.1 - 0.073 12.6 0.1 0.53 9.8 0.0 2.2 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 KOG97934.1 - 0.083 12.4 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Septin PF00735.18 KOG97934.1 - 0.087 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Septin NB-ARC PF00931.22 KOG97934.1 - 0.094 11.9 0.2 0.37 9.9 0.1 1.8 2 0 0 2 2 2 0 NB-ARC domain CbiA PF01656.23 KOG97934.1 - 0.14 12.2 0.0 0.17 11.9 0.0 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain T2SSE PF00437.20 KOG97934.1 - 0.14 11.2 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Peptidase_M24 PF00557.24 KOG97935.1 - 3.1e-54 183.8 0.0 3.9e-54 183.5 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 KOG97935.1 - 3.6e-16 59.2 5.5 3.6e-16 59.2 5.5 1.8 2 0 0 2 2 2 1 zf-MYND-like zinc finger, mRNA-binding CBM39 PF15886.5 KOG97935.1 - 0.18 11.7 0.3 13 5.7 0.1 2.3 2 0 0 2 2 2 0 Carbohydrate binding domain (family 32) zf-MYND PF01753.18 KOG97935.1 - 0.64 10.2 9.6 0.34 11.0 5.8 2.4 2 0 0 2 2 2 0 MYND finger dCMP_cyt_deam_1 PF00383.23 KOG97936.1 - 6.3e-21 74.1 0.4 7.9e-21 73.8 0.4 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 KOG97936.1 - 2.5e-12 47.1 0.0 5.5e-11 42.8 0.0 2.0 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 KOG97936.1 - 0.38 10.3 5.1 6 6.4 0.3 2.1 1 1 1 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases DHHC PF01529.20 KOG97937.1 - 1.2e-31 109.6 11.0 1.2e-31 109.6 11.0 2.4 2 0 0 2 2 2 1 DHHC palmitoyltransferase SDF PF00375.18 KOG97937.1 - 0.056 12.5 0.2 0.056 12.5 0.2 2.0 2 1 0 2 2 2 0 Sodium:dicarboxylate symporter family DUF35_N PF12172.8 KOG97937.1 - 0.27 11.1 3.5 0.62 10.0 3.5 1.5 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) SNF2_N PF00176.23 KOG97938.1 - 6.9e-41 140.1 1.7 1.3e-40 139.3 0.0 2.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain zf-C3HC4_2 PF13923.6 KOG97938.1 - 3e-11 43.0 7.3 7.9e-11 41.6 7.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOG97938.1 - 4.4e-10 39.7 8.6 1.3e-09 38.3 8.6 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KOG97938.1 - 6.7e-09 35.5 8.7 1.8e-08 34.1 8.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOG97938.1 - 9.7e-07 28.6 9.7 1.8e-06 27.7 9.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOG97938.1 - 3.4e-06 27.0 5.7 1.1e-05 25.3 5.7 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOG97938.1 - 7.4e-06 25.8 7.7 1.7e-05 24.7 7.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 KOG97938.1 - 1.3e-05 25.4 5.3 3.9e-05 23.8 5.3 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain Helicase_C PF00271.31 KOG97938.1 - 1.9e-05 24.9 0.0 6.9e-05 23.2 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Prok-RING_4 PF14447.6 KOG97938.1 - 0.00053 19.8 9.6 0.0012 18.7 9.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 KOG97938.1 - 0.0039 17.2 1.3 0.4 10.8 3.6 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 KOG97938.1 - 0.006 16.7 8.2 0.017 15.3 8.2 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 KOG97938.1 - 0.02 15.0 6.1 0.06 13.5 6.1 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 ResIII PF04851.15 KOG97938.1 - 0.032 14.2 0.0 0.032 14.2 0.0 2.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Baculo_IE-1 PF05290.11 KOG97938.1 - 0.036 14.0 4.5 0.11 12.4 3.0 2.7 2 0 0 2 2 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_11 PF17123.5 KOG97938.1 - 0.31 10.8 7.0 0.97 9.2 7.0 2.0 1 0 0 1 1 1 0 RING-like zinc finger zf-Nse PF11789.8 KOG97938.1 - 0.8 9.6 3.9 3.1 7.7 3.9 2.0 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-P11 PF03854.14 KOG97938.1 - 0.84 9.4 12.6 0.17 11.5 8.8 1.9 2 0 0 2 2 1 0 P-11 zinc finger Pkinase PF00069.25 KOG97939.1 - 2.4e-56 191.0 0.0 1.1e-55 188.9 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG97939.1 - 1.7e-21 76.7 0.0 2.7e-20 72.7 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG97939.1 - 0.00012 21.5 0.1 0.36 10.1 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 KOG97939.1 - 0.00018 21.0 0.0 0.00039 19.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF792 PF05632.11 KOG97939.1 - 0.0035 17.2 0.0 0.0074 16.2 0.0 1.5 1 0 0 1 1 1 1 Borrelia burgdorferi protein of unknown function (DUF792) ABC_tran PF00005.27 KOG97940.1 - 9.4e-44 149.3 0.1 1.2e-21 77.7 0.0 4.5 4 2 0 4 4 2 2 ABC transporter 4HB PF17947.1 KOG97940.1 - 1.6e-29 101.8 0.2 5.9e-29 100.0 0.2 2.1 1 0 0 1 1 1 1 Four helical bundle domain AAA_21 PF13304.6 KOG97940.1 - 1.2e-16 61.4 1.1 0.0064 16.3 0.0 4.5 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOG97940.1 - 1.3e-16 60.7 0.1 4.2e-06 26.4 0.0 4.1 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOG97940.1 - 4e-11 43.8 4.3 0.00029 21.4 0.0 3.3 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 KOG97940.1 - 2.7e-08 33.9 0.0 0.00016 21.6 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_28 PF13521.6 KOG97940.1 - 3.9e-08 33.7 0.0 0.0093 16.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 KOG97940.1 - 4.4e-08 32.7 0.0 0.0067 16.1 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 KOG97940.1 - 7.1e-08 32.8 0.0 0.0072 16.6 0.0 3.9 4 0 0 4 4 3 2 AAA domain MMR_HSR1 PF01926.23 KOG97940.1 - 2.9e-07 30.6 0.0 0.0021 18.1 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase RNA_helicase PF00910.22 KOG97940.1 - 1.1e-06 28.9 0.0 0.13 12.7 0.0 3.1 2 0 0 2 2 2 2 RNA helicase AAA PF00004.29 KOG97940.1 - 2.5e-06 27.9 0.0 0.11 12.9 0.0 4.1 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 KOG97940.1 - 3e-06 27.4 0.0 4.5e-05 23.6 0.0 2.5 2 0 0 2 2 2 1 Dynamin family Rad17 PF03215.15 KOG97940.1 - 5.2e-06 26.5 0.0 0.076 12.9 0.0 2.8 3 0 0 3 3 2 2 Rad17 P-loop domain MeaB PF03308.16 KOG97940.1 - 1.4e-05 24.3 0.0 0.1 11.6 0.0 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 KOG97940.1 - 3.9e-05 23.5 2.9 0.21 11.3 0.0 3.6 4 0 0 4 4 2 2 AAA ATPase domain AAA_18 PF13238.6 KOG97940.1 - 5.5e-05 23.7 0.0 0.78 10.3 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KOG97940.1 - 6.6e-05 23.3 0.0 0.25 11.7 0.0 3.0 3 0 0 3 3 2 1 AAA ATPase domain DUF87 PF01935.17 KOG97940.1 - 0.00011 22.4 0.7 0.39 10.8 0.0 4.2 5 0 0 5 5 3 1 Helicase HerA, central domain AAA_33 PF13671.6 KOG97940.1 - 0.00015 21.9 0.0 0.6 10.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain ParcG PF10274.9 KOG97940.1 - 0.00022 21.4 0.6 2.4 8.2 0.0 3.2 2 1 0 3 3 3 1 Parkin co-regulated protein ATPase_2 PF01637.18 KOG97940.1 - 0.00026 21.0 0.0 0.21 11.4 0.0 3.1 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 KOG97940.1 - 0.00035 20.6 0.0 0.77 9.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_27 PF13514.6 KOG97940.1 - 0.00053 19.6 0.0 0.56 9.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 KOG97940.1 - 0.00066 19.6 0.0 0.21 11.5 0.0 2.6 2 0 0 2 2 2 1 NACHT domain PduV-EutP PF10662.9 KOG97940.1 - 0.00088 19.0 0.0 0.28 10.9 0.0 2.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 KOG97940.1 - 0.0014 18.4 0.1 1.5 8.5 0.0 3.5 4 0 0 4 4 2 1 AAA domain SbcCD_C PF13558.6 KOG97940.1 - 0.0016 18.6 0.0 0.79 10.0 0.0 3.3 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Adaptin_N PF01602.20 KOG97940.1 - 0.0034 16.0 1.2 0.034 12.7 0.9 2.1 2 0 0 2 2 2 1 Adaptin N terminal region AAA_30 PF13604.6 KOG97940.1 - 0.0095 15.7 0.0 9.2 5.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain HEAT_EZ PF13513.6 KOG97940.1 - 0.011 16.2 0.0 3.7 8.1 0.0 3.4 3 0 0 3 3 2 0 HEAT-like repeat G-alpha PF00503.20 KOG97940.1 - 0.012 14.8 0.0 4.7 6.3 0.0 2.4 2 0 0 2 2 2 0 G-protein alpha subunit HEAT_2 PF13646.6 KOG97940.1 - 0.013 15.9 0.2 2.8 8.4 0.0 3.2 2 1 1 3 3 3 0 HEAT repeats AAA_13 PF13166.6 KOG97940.1 - 0.013 14.1 2.4 6.1 5.4 0.0 3.8 4 0 0 4 4 4 0 AAA domain Vac14_Fab1_bd PF12755.7 KOG97940.1 - 0.014 16.0 0.5 16 6.1 0.0 3.9 3 1 1 4 4 3 0 Vacuolar 14 Fab1-binding region Adeno_IVa2 PF02456.15 KOG97940.1 - 0.015 14.1 0.0 2.9 6.6 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein UME PF08064.13 KOG97940.1 - 0.019 14.9 1.0 1.4 8.9 0.5 3.0 2 1 1 3 3 2 0 UME (NUC010) domain NTPase_1 PF03266.15 KOG97940.1 - 0.02 14.8 0.2 8.6 6.2 0.0 2.9 2 0 0 2 2 2 0 NTPase Tricho_coat PF05892.11 KOG97940.1 - 0.022 14.6 0.0 0.064 13.0 0.0 1.7 2 0 0 2 2 1 0 Trichovirus coat protein CLP1_P PF16575.5 KOG97940.1 - 0.023 14.5 0.0 1.9 8.2 0.0 2.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Cytidylate_kin PF02224.18 KOG97940.1 - 0.026 14.2 0.0 6.8 6.4 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase Mg_chelatase PF01078.21 KOG97940.1 - 0.029 13.7 0.2 1.5 8.2 0.0 3.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI cobW PF02492.19 KOG97940.1 - 0.03 13.9 0.0 13 5.3 0.0 3.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 KOG97940.1 - 0.032 13.7 0.0 6.6 6.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Septin PF00735.18 KOG97940.1 - 0.034 13.4 0.1 2.7 7.2 0.0 2.7 3 0 0 3 3 3 0 Septin Roc PF08477.13 KOG97940.1 - 0.038 14.2 0.0 12 6.2 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase T2SSE PF00437.20 KOG97940.1 - 0.045 12.8 0.0 0.54 9.3 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein HEAT PF02985.22 KOG97940.1 - 0.047 14.0 0.0 7.5 7.1 0.0 3.8 4 0 0 4 4 2 0 HEAT repeat IstB_IS21 PF01695.17 KOG97940.1 - 0.049 13.4 0.0 10 5.8 0.0 2.9 2 0 0 2 2 2 0 IstB-like ATP binding protein NB-ARC PF00931.22 KOG97940.1 - 0.049 12.8 0.0 1.8 7.7 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain PRK PF00485.18 KOG97940.1 - 0.05 13.3 0.0 2.4 7.8 0.0 2.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family DUF5584 PF17822.1 KOG97940.1 - 0.052 13.0 0.1 1.1 8.6 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5584) MutS_V PF00488.21 KOG97940.1 - 0.067 13.2 0.1 11 6.0 0.1 2.5 2 0 0 2 2 2 0 MutS domain V AAA_5 PF07728.14 KOG97940.1 - 0.1 12.6 0.0 29 4.6 0.0 3.5 4 0 0 4 4 2 0 AAA domain (dynein-related subfamily) RE_HindVP PF09519.10 KOG97940.1 - 0.12 11.4 0.6 0.2 10.6 0.6 1.3 1 0 0 1 1 1 0 HindVP restriction endonuclease FeoB_N PF02421.18 KOG97940.1 - 0.24 10.9 2.3 1.2 8.7 0.1 2.7 3 0 0 3 3 2 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 KOG97940.1 - 0.25 11.1 2.0 8 6.2 0.1 2.8 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein ABC_tran_Xtn PF12848.7 KOG97940.1 - 5.5 7.1 7.4 1.3 9.1 0.1 2.7 2 0 0 2 2 2 0 ABC transporter EF-hand_7 PF13499.6 KOG97941.1 - 5.9e-06 26.7 0.5 5.9e-06 26.7 0.5 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOG97941.1 - 0.00055 19.3 0.9 0.34 10.5 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KOG97941.1 - 0.001 18.8 1.8 0.11 12.5 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain Mpv17_PMP22 PF04117.12 KOG97942.1 - 7.1e-26 90.2 4.0 1.3e-25 89.4 4.0 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family ABC1 PF03109.16 KOG97943.1 - 3.9e-34 117.4 0.0 8.6e-34 116.3 0.0 1.6 1 0 0 1 1 1 1 ABC1 family Tfb4 PF03850.14 KOG97943.1 - 0.00094 18.8 0.4 0.0019 17.7 0.1 1.6 2 0 0 2 2 2 1 Transcription factor Tfb4 RIO1 PF01163.22 KOG97943.1 - 0.0011 18.6 0.0 0.0063 16.1 0.0 2.1 2 0 0 2 2 2 1 RIO1 family FGase PF05013.12 KOG97943.1 - 0.043 14.0 0.2 1.1 9.4 0.0 2.5 3 0 0 3 3 3 0 N-formylglutamate amidohydrolase bZIP_2 PF07716.15 KOG97944.1 - 0.00098 19.2 3.4 0.00098 19.2 3.4 3.4 2 1 1 3 3 3 1 Basic region leucine zipper TPR_MLP1_2 PF07926.12 KOG97944.1 - 0.0011 19.0 12.0 0.0011 19.0 12.0 2.1 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 KOG97944.1 - 0.0018 18.3 4.8 0.0034 17.4 4.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 KOG97944.1 - 0.0077 16.3 2.0 0.0077 16.3 2.0 3.0 2 1 2 4 4 3 1 bZIP transcription factor Svf1 PF08622.10 KOG97944.1 - 0.018 15.1 1.0 0.023 14.7 1.0 1.5 1 1 0 1 1 1 0 Svf1-like N-terminal lipocalin domain Focal_AT PF03623.13 KOG97944.1 - 0.028 14.4 2.2 0.028 14.4 2.2 1.9 1 1 0 2 2 2 0 Focal adhesion targeting region TSC22 PF01166.18 KOG97944.1 - 0.057 13.7 1.8 0.057 13.7 1.8 2.7 2 1 0 2 2 2 0 TSC-22/dip/bun family FUSC PF04632.12 KOG97944.1 - 0.08 11.5 0.4 0.088 11.3 0.4 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family ATG16 PF08614.11 KOG97944.1 - 0.11 12.7 15.6 0.094 12.9 14.2 1.4 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 KOG97944.1 - 0.16 12.4 12.8 0.2 12.1 12.8 1.2 1 0 0 1 1 1 0 Fez1 V_ATPase_I PF01496.19 KOG97944.1 - 0.17 9.8 11.0 0.21 9.4 11.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 KOG97944.1 - 0.99 8.7 6.3 1.2 8.4 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 KOG97944.1 - 1.1 9.8 20.1 3.2 8.3 20.1 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region Jnk-SapK_ap_N PF09744.9 KOG97944.1 - 1.2 9.3 18.5 1.4 9.1 12.1 2.1 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Pox_A_type_inc PF04508.12 KOG97944.1 - 3.5 7.6 9.3 1.8 8.5 0.5 3.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Cnn_1N PF07989.11 KOG97944.1 - 4 7.7 20.8 11 6.2 8.4 3.2 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 ATP-synt_E PF05680.12 KOG97944.1 - 7 7.1 7.3 2 8.8 3.6 1.9 1 1 1 2 2 2 0 ATP synthase E chain Spc24 PF08286.11 KOG97944.1 - 9.4 6.5 18.1 9 6.6 9.8 2.9 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Zn_clus PF00172.18 KOG97946.1 - 7.3e-08 32.4 8.3 1.4e-07 31.5 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 KOG97946.1 - 0.48 10.5 9.2 0.079 13.0 3.7 2.5 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 baeRF_family6 PF18848.1 KOG97947.1 - 0.0022 18.4 2.6 0.0039 17.6 0.2 2.5 2 1 1 3 3 3 1 Bacterial archaeo-eukaryotic release factor family 6 baeRF_family7 PF18849.1 KOG97947.1 - 0.014 15.6 0.1 0.041 14.1 0.1 1.8 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 7 Glycogen_syn PF05693.13 KOG97948.1 - 0 1107.3 0.0 0 1107.1 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 KOG97948.1 - 1.5e-09 37.6 0.0 1.5e-06 27.8 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOG97948.1 - 4.3e-07 30.4 0.0 0.001 19.5 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KOG97948.1 - 4.1e-05 23.6 0.1 0.00011 22.3 0.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 KOG97948.1 - 0.00011 22.6 0.0 0.00024 21.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Cpn60_TCP1 PF00118.24 KOG97949.1 - 6.2e-83 279.1 9.9 1.5e-82 277.8 9.9 1.5 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family DAGK_cat PF00781.24 KOG97950.1 - 1e-28 99.5 0.0 1.8e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NOA36 PF06524.12 KOG97950.1 - 3.8 6.7 9.3 8.4 5.6 9.3 1.5 1 0 0 1 1 1 0 NOA36 protein Ras PF00071.22 KOG97951.1 - 9e-58 194.4 0.4 1.1e-57 194.2 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG97951.1 - 1e-37 129.0 0.1 1.7e-37 128.3 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG97951.1 - 3.8e-16 59.0 0.4 4.3e-16 58.8 0.4 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KOG97951.1 - 1.4e-05 25.1 0.1 0.079 12.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 KOG97951.1 - 1.7e-05 24.3 0.0 3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KOG97951.1 - 1.9e-05 24.7 0.0 3.3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOG97951.1 - 3.5e-05 23.3 0.2 4.5e-05 22.9 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOG97951.1 - 0.00089 18.9 0.0 0.009 15.6 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATPase_2 PF01637.18 KOG97951.1 - 0.00095 19.1 1.5 0.0029 17.6 0.1 1.9 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea PduV-EutP PF10662.9 KOG97951.1 - 0.002 17.9 0.9 0.015 15.0 0.9 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 KOG97951.1 - 0.0054 16.3 0.0 0.0089 15.6 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 KOG97951.1 - 0.015 15.0 0.3 0.021 14.6 0.3 1.6 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOG97951.1 - 0.024 14.9 0.0 0.065 13.5 0.0 1.7 1 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KOG97951.1 - 0.032 14.6 0.0 0.052 13.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain ResIII PF04851.15 KOG97951.1 - 0.056 13.4 0.2 0.082 12.9 0.2 1.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DLIC PF05783.11 KOG97951.1 - 0.058 12.2 0.2 0.097 11.5 0.1 1.3 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) NACHT PF05729.12 KOG97951.1 - 0.081 12.8 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_15 PF13175.6 KOG97951.1 - 0.18 11.5 7.3 5.1 6.7 3.4 2.1 1 1 0 2 2 2 0 AAA ATPase domain Red1 PF07964.11 KOG97952.1 - 1.9e-174 582.0 49.9 2.6e-174 581.5 49.9 1.2 1 0 0 1 1 1 1 Rec10 / Red1 Ribosomal_S28e PF01200.18 KOG97953.1 - 7.1e-32 109.2 2.9 7.8e-32 109.1 2.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e XLF PF09302.11 KOG97954.1 - 4.5e-10 40.0 0.3 8.1e-10 39.1 0.3 1.4 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component Fungal_trans PF04082.18 KOG97955.1 - 3e-16 59.3 5.4 7.4e-16 58.0 5.6 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG97955.1 - 1.9e-06 27.9 10.6 3.4e-06 27.1 8.6 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DpnI_C PF17726.1 KOG97956.1 - 0.04 14.0 0.0 0.22 11.7 0.0 2.3 1 0 0 1 1 1 0 Dam-replacing HTH domain PHtD_u1 PF16645.5 KOG97956.1 - 0.12 12.8 0.5 0.4 11.2 0.5 1.9 1 0 0 1 1 1 0 Unstructured region on Pneumococcal histidine triad protein Longin PF13774.6 KOG97957.1 - 8.1e-19 67.5 0.4 2.5e-18 65.9 0.4 1.8 2 0 0 2 2 2 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 KOG97957.1 - 6.6e-17 61.1 0.2 1.3e-16 60.1 0.2 1.5 1 0 0 1 1 1 1 Synaptobrevin DUF1664 PF07889.12 KOG97957.1 - 0.00038 20.5 0.1 0.0007 19.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Phi-29_GP16_7 PF06720.11 KOG97957.1 - 0.096 12.5 0.6 0.14 11.9 0.6 1.2 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 E1-E2_ATPase PF00122.20 KOG97957.1 - 0.2 11.2 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 E1-E2 ATPase DcpS PF05652.12 KOG97958.1 - 4.6e-36 123.8 0.1 7.2e-36 123.2 0.1 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 KOG97958.1 - 1.8e-33 115.4 0.5 6.1e-33 113.7 0.1 1.9 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 KOG97958.1 - 0.17 12.7 0.6 9.5 7.0 0.2 3.0 3 0 0 3 3 3 0 HIT domain DUF4187 PF13821.6 KOG97959.1 - 3.6e-19 68.3 0.8 1.1e-18 66.7 0.8 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 KOG97959.1 - 7.2e-14 51.4 0.6 1.3e-13 50.6 0.6 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KOG97959.1 - 0.0037 17.3 0.5 0.0037 17.3 0.5 2.3 3 0 0 3 3 3 1 G-patch domain Cnd1 PF12717.7 KOG97960.1 - 4e-50 170.0 18.6 2.8e-43 147.8 0.1 5.6 6 0 0 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 KOG97960.1 - 3.3e-48 163.7 2.6 3.3e-48 163.7 2.6 2.6 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 KOG97960.1 - 1.4e-12 46.7 5.6 0.078 13.3 0.0 6.4 6 0 0 6 6 6 4 HEAT repeat HEAT_2 PF13646.6 KOG97960.1 - 1.1e-10 41.7 0.0 0.0027 18.1 0.0 4.2 4 1 0 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 KOG97960.1 - 4.1e-07 30.4 1.0 1.3 9.6 0.0 4.8 4 0 0 4 4 4 2 HEAT-like repeat RTP1_C1 PF10363.9 KOG97960.1 - 0.00048 20.3 5.0 0.066 13.4 0.0 4.4 4 1 1 5 5 5 3 Required for nuclear transport of RNA pol II C-terminus 1 YtzH PF14165.6 KOG97960.1 - 1.9 8.9 5.6 1.8 9.0 0.1 3.8 4 0 0 4 4 4 0 YtzH-like protein CBM_21 PF03370.13 KOG97961.1 - 4.5e-21 75.1 5.5 1.2e-20 73.8 5.5 1.7 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) Peptidase_C93 PF06035.11 KOG97961.1 - 0.0081 16.0 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 Bacterial transglutaminase-like cysteine proteinase BTLCP CBM53 PF16760.5 KOG97961.1 - 0.25 12.0 5.6 2.6 8.7 5.6 2.6 1 1 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) MCM PF00493.23 KOG97962.1 - 5.8e-105 349.4 0.0 1e-104 348.5 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KOG97962.1 - 4.9e-37 126.6 0.1 9.7e-37 125.6 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KOG97962.1 - 4.6e-28 97.5 1.7 1.3e-27 96.0 1.7 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 KOG97962.1 - 3.9e-17 62.7 0.2 1.2e-16 61.2 0.2 1.8 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 KOG97962.1 - 3e-06 27.3 0.0 1e-05 25.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KOG97962.1 - 3.1e-06 26.7 0.0 0.00063 19.2 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KOG97962.1 - 0.00041 20.2 0.1 0.0028 17.5 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KOG97962.1 - 0.025 14.3 0.0 1.2 8.9 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA PF00004.29 KOG97962.1 - 0.097 13.1 0.1 0.85 10.0 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) LSM PF01423.22 KOG97963.1 - 2.1e-17 62.5 0.4 2.9e-17 62.1 0.4 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 KOG97963.1 - 0.047 13.3 0.0 0.088 12.5 0.0 1.4 1 0 0 1 1 1 0 Hfq protein DEAD PF00270.29 KOG97964.1 - 1.1e-42 145.8 0.6 2.1e-42 144.9 0.6 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG97964.1 - 2.8e-30 104.9 0.3 3.7e-29 101.3 0.0 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG97964.1 - 3.1e-06 27.3 0.6 1.4e-05 25.2 0.1 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DnaI_N PF07319.11 KOG97964.1 - 0.035 14.8 5.7 1.6 9.5 0.6 3.2 2 2 0 2 2 2 0 Primosomal protein DnaI N-terminus CMS1 PF14617.6 KOG97964.1 - 0.065 12.6 0.1 0.065 12.6 0.1 2.5 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit Microtub_bind PF13931.6 KOG97964.1 - 0.37 11.2 6.4 0.9 9.9 0.7 2.6 2 1 0 2 2 2 0 Kinesin-associated microtubule-binding SecA_DEAD PF07517.14 KOG97964.1 - 0.43 9.8 3.4 9.9 5.3 0.0 2.8 3 0 0 3 3 3 0 SecA DEAD-like domain CPSF73-100_C PF11718.8 KOG97965.1 - 1.7e-54 184.7 1.4 2.6e-54 184.0 1.4 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 KOG97965.1 - 1.1e-28 99.7 0.0 2.5e-28 98.5 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 KOG97965.1 - 6.7e-24 85.0 0.2 1.1e-23 84.3 0.2 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 KOG97965.1 - 1.4e-19 70.3 0.0 3e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 KOG97965.1 - 3.1e-19 68.7 0.0 6.3e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 KOG97965.1 - 7.8e-07 28.8 0.0 1.6e-05 24.5 0.0 2.8 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 KOG97965.1 - 4.9e-05 23.3 0.0 0.00014 21.8 0.0 1.8 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Fungal_trans PF04082.18 KOG97966.1 - 3.7e-22 78.6 4.9 1.4e-21 76.7 4.9 2.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG97966.1 - 1.3e-06 28.4 10.4 3.2e-06 27.1 10.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RF-1 PF00472.20 KOG97967.1 - 1.5e-18 66.8 4.3 3.2e-18 65.8 4.3 1.6 1 1 0 1 1 1 1 RF-1 domain DUF1640 PF07798.11 KOG97968.1 - 3.9e-22 79.1 6.8 5e-22 78.8 6.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Tweety PF04906.13 KOG97968.1 - 0.031 13.0 1.0 0.052 12.2 1.0 1.3 1 0 0 1 1 1 0 Tweety ECH_1 PF00378.20 KOG97969.1 - 2.6e-16 59.7 0.0 5e-16 58.8 0.0 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KOG97969.1 - 1.1e-08 35.0 0.0 1.4e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Init_tRNA_PT PF04179.12 KOG97969.1 - 0.062 13.6 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain Methyltransf_16 PF10294.9 KOG97970.1 - 2.3e-14 53.5 0.0 3.2e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 KOG97970.1 - 2.6e-05 24.1 0.0 3.5e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOG97970.1 - 0.082 13.7 0.0 0.14 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Glyco_hydro_18 PF00704.28 KOG97971.1 - 2.6e-27 96.4 1.7 3.7e-27 95.9 1.7 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 KOG97971.1 - 2.5e-07 30.6 10.8 2.5e-07 30.6 10.8 5.2 1 1 4 5 5 5 1 Carbohydrate binding domain (family 19) RIFIN PF02009.16 KOG97971.1 - 3.4 7.5 11.3 5.1 6.9 11.3 1.4 1 0 0 1 1 1 0 Rifin Hamartin PF04388.12 KOG97971.1 - 7 5.2 32.7 9.4 4.8 32.7 1.1 1 0 0 1 1 1 0 Hamartin protein GCIP PF13324.6 KOG97972.1 - 4.6e-31 108.4 0.9 6.3e-31 107.9 0.9 1.2 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting Imm6 PF14434.6 KOG97972.1 - 0.7 9.8 4.7 1.2 9.0 0.8 2.5 2 0 0 2 2 2 0 Immunity protein Imm6 Hus1 PF04005.12 KOG97973.1 - 3.7e-22 78.8 0.2 3.9e-15 55.7 0.0 2.3 2 0 0 2 2 2 2 Hus1-like protein GTP_EFTU PF00009.27 KOG97974.1 - 7.3e-52 175.7 0.1 6.8e-51 172.6 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 KOG97974.1 - 4.3e-42 142.6 6.8 9.6e-42 141.5 6.8 1.6 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 KOG97974.1 - 6e-18 64.7 0.0 1.3e-17 63.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOG97974.1 - 1.9e-08 34.6 1.4 4.4e-08 33.4 1.4 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOG97974.1 - 2.8e-05 24.2 0.4 9.6e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase RF3_C PF16658.5 KOG97974.1 - 0.014 15.2 0.1 0.045 13.6 0.0 1.9 2 0 0 2 2 2 0 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 KOG97974.1 - 0.06 12.8 0.0 0.19 11.2 0.0 1.9 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF1931 PF09123.11 KOG97974.1 - 0.075 13.1 0.1 0.38 10.9 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1931) EFG_II PF14492.6 KOG97974.1 - 0.11 12.6 0.0 0.29 11.2 0.0 1.8 1 0 0 1 1 1 0 Elongation Factor G, domain II Epimerase PF01370.21 KOG97975.1 - 2.5e-05 23.9 0.0 4.4e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KOG97975.1 - 0.00017 21.5 0.0 0.00048 20.1 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 KOG97975.1 - 0.00024 20.2 0.0 0.00036 19.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 KOG97975.1 - 0.00049 19.6 0.0 0.00087 18.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 KOG97975.1 - 0.014 14.6 0.1 0.16 11.1 0.0 2.2 1 1 1 2 2 2 0 Male sterility protein RmlD_sub_bind PF04321.17 KOG97975.1 - 0.11 11.6 0.0 0.29 10.2 0.0 1.6 2 0 0 2 2 2 0 RmlD substrate binding domain IF-2B PF01008.17 KOG97976.1 - 4.1e-93 311.7 0.1 5.5e-93 311.2 0.1 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF1804 PF08822.11 KOG97976.1 - 0.0011 19.0 0.1 0.0044 17.0 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1804) TPR_2 PF07719.17 KOG97977.1 - 3e-07 30.0 0.0 0.00058 19.8 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOG97977.1 - 1.1e-06 29.1 1.3 2.5e-06 27.9 0.1 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOG97977.1 - 5.6e-06 26.0 0.1 0.013 15.3 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOG97977.1 - 2.8e-05 24.3 0.5 0.0086 16.3 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOG97977.1 - 0.00041 20.9 2.3 0.00075 20.1 0.1 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOG97977.1 - 0.00068 19.8 0.7 0.0049 17.1 0.1 2.4 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 KOG97977.1 - 0.0016 18.1 0.2 0.053 13.2 0.0 2.9 3 0 0 3 3 3 1 TPR repeat TPR_16 PF13432.6 KOG97977.1 - 0.0088 16.7 0.1 0.022 15.4 0.0 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOG97977.1 - 0.012 16.2 0.2 0.053 14.2 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOG97977.1 - 0.014 15.5 2.0 0.16 12.1 0.8 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.6 KOG97977.1 - 0.034 13.3 0.1 0.066 12.4 0.0 1.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOG97977.1 - 0.037 14.6 1.1 0.074 13.7 0.3 2.0 2 0 0 2 2 1 0 Tetratricopeptide repeat NRBF2_MIT PF17169.4 KOG97977.1 - 0.045 14.0 0.0 0.19 12.0 0.0 2.0 2 0 0 2 2 2 0 MIT domain of nuclear receptor-binding factor 2 TPR_8 PF13181.6 KOG97977.1 - 0.068 13.4 0.0 1.1 9.6 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat AAA_6 PF12774.7 KOG97977.1 - 0.14 11.1 0.1 0.17 10.8 0.1 1.1 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Ras PF00071.22 KOG97978.1 - 1.5e-51 174.2 0.0 1.9e-51 173.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG97978.1 - 1.3e-31 109.3 0.1 3.6e-31 107.9 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG97978.1 - 5e-12 45.6 0.0 7e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 KOG97978.1 - 0.00028 21.3 0.2 0.0023 18.3 0.2 2.1 1 1 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.23 KOG97978.1 - 0.00039 20.5 0.0 0.00089 19.3 0.0 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOG97978.1 - 0.0012 18.3 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOG97978.1 - 0.0017 17.9 0.4 0.0073 15.9 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KOG97978.1 - 0.01 15.3 0.0 0.017 14.5 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KOG97978.1 - 0.016 14.4 2.6 1.4 8.0 0.1 2.9 2 1 1 3 3 3 0 G-protein alpha subunit ATPase PF06745.13 KOG97978.1 - 0.019 14.3 0.2 0.031 13.6 0.2 1.3 1 0 0 1 1 1 0 KaiC Pox_A32 PF04665.12 KOG97978.1 - 0.02 14.4 0.1 0.038 13.4 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein RsgA_GTPase PF03193.16 KOG97978.1 - 0.021 14.8 0.1 6.7 6.6 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 KOG97978.1 - 0.03 13.9 0.1 0.051 13.1 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ArgoMid PF16487.5 KOG97978.1 - 0.046 14.0 0.7 0.069 13.4 0.1 1.7 2 0 0 2 2 1 0 Mid domain of argonaute AAA_24 PF13479.6 KOG97978.1 - 0.066 12.9 0.3 0.1 12.3 0.3 1.5 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 KOG97978.1 - 0.082 12.9 0.1 0.22 11.6 0.1 1.7 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 KOG97978.1 - 0.1 12.8 0.6 0.22 11.7 0.2 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KOG97978.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 KOG97978.1 - 0.14 11.4 0.3 0.25 10.6 0.0 1.6 2 0 0 2 2 2 0 Septin ATP_sub_h PF10775.9 KOG97979.1 - 1e-23 83.1 0.5 1.4e-23 82.7 0.5 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h TMEM154 PF15102.6 KOG97980.1 - 0.035 14.0 0.1 0.047 13.6 0.1 1.2 1 0 0 1 1 1 0 TMEM154 protein family DUF3852 PF12963.7 KOG97980.1 - 0.043 14.1 0.1 0.056 13.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3852) Rax2 PF12768.7 KOG97980.1 - 0.084 12.3 0.1 0.084 12.3 0.1 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity zf-U1 PF06220.12 KOG97981.1 - 1e-18 66.8 5.8 2.3e-18 65.6 5.8 1.6 1 0 0 1 1 1 1 U1 zinc finger G_glu_transpept PF01019.21 KOG97982.1 - 4.7e-152 507.3 0.0 5.6e-152 507.1 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase HRI1 PF16815.5 KOG97983.1 - 2.4e-43 148.5 0.0 2.6e-43 148.4 0.0 1.0 1 0 0 1 1 1 1 Protein HRI1 Cys_Met_Meta_PP PF01053.20 KOG97984.1 - 6.2e-150 499.0 0.0 7.1e-150 498.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KOG97984.1 - 2.1e-10 40.3 0.0 3e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KOG97984.1 - 5.8e-09 35.4 0.1 9.2e-09 34.7 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KOG97984.1 - 1.4e-08 34.5 0.0 2.1e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 KOG97984.1 - 2e-08 33.9 0.0 3.8e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Met_gamma_lyase PF06838.11 KOG97984.1 - 2.2e-05 23.1 0.1 3.6e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Methionine gamma-lyase GDC-P PF02347.16 KOG97984.1 - 0.027 13.3 0.0 0.038 12.8 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein Asparaginase_C PF17763.1 KOG97984.1 - 0.033 14.4 0.0 0.084 13.1 0.0 1.6 1 0 0 1 1 1 0 Glutaminase/Asparaginase C-terminal domain CPSase_L_D2 PF02786.17 KOG97984.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Aconitase PF00330.20 KOG97985.1 - 2.1e-151 505.1 0.0 2.7e-151 504.7 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KOG97985.1 - 2.6e-47 160.4 0.0 5e-47 159.5 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain PI3_PI4_kinase PF00454.27 KOG97986.1 - 8.6e-43 146.9 0.0 1.7e-40 139.4 0.0 2.7 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 KOG97986.1 - 1e-38 132.6 0.0 2.2e-38 131.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF5111 PF17138.4 KOG97986.1 - 0.15 11.9 0.0 0.46 10.4 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5111) UQ_con PF00179.26 KOG97987.1 - 5.1e-36 123.4 0.1 5.6e-36 123.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Polysacc_deac_1 PF01522.21 KOG97988.1 - 1.4e-23 83.1 0.0 2.5e-23 82.3 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 KOG97988.1 - 9.9e-05 21.7 0.0 0.00014 21.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Polysacc_deac_1 PF01522.21 KOG97990.1 - 1.3e-26 93.0 0.0 2e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 KOG97990.1 - 0.0039 16.4 0.0 0.0052 16.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 GRIP PF01465.20 KOG97991.1 - 3.8e-14 52.3 0.4 1.1e-13 50.8 0.4 1.9 1 0 0 1 1 1 1 GRIP domain MscS_porin PF12795.7 KOG97991.1 - 6.4e-08 32.4 25.0 6.4e-08 32.4 25.0 6.4 2 2 4 6 6 6 2 Mechanosensitive ion channel porin domain ATG16 PF08614.11 KOG97991.1 - 3.6e-07 30.6 136.4 0.0045 17.2 3.9 7.5 1 1 7 8 8 8 5 Autophagy protein 16 (ATG16) Spc7 PF08317.11 KOG97991.1 - 3.1e-05 23.0 149.2 0.027 13.4 22.5 7.4 1 1 6 7 7 7 6 Spc7 kinetochore protein RasGEF PF00617.19 KOG97992.1 - 1.2e-53 182.0 2.4 1.2e-53 182.0 2.4 2.6 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 KOG97992.1 - 4.8e-22 78.2 0.4 4.4e-21 75.1 0.0 3.0 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_1 PF00018.28 KOG97992.1 - 7e-07 28.8 0.2 1.9e-06 27.4 0.2 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOG97992.1 - 2.5e-06 27.3 0.0 4.9e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOG97992.1 - 2.7e-05 23.8 0.1 6.4e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF4231 PF14015.6 KOG97992.1 - 0.12 12.8 0.7 1.4 9.4 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) ELMO_CED12 PF04727.13 KOG97992.1 - 0.13 12.3 4.2 1.2 9.3 0.4 3.0 2 0 0 2 2 2 0 ELMO/CED-12 family DUF572 PF04502.13 KOG97993.1 - 0.018 14.7 1.8 0.032 13.8 1.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) HrpB7 PF09486.10 KOG97993.1 - 1.3 9.4 4.1 23 5.3 0.0 2.7 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Ribonucleas_3_3 PF14622.6 KOG97994.1 - 1.9e-22 79.8 0.0 3.2e-22 79.1 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 KOG97994.1 - 3.5e-07 30.8 0.0 9.2e-07 29.4 0.0 1.7 1 1 0 1 1 1 1 Ribonuclease III domain GIT_SHD PF08518.11 KOG97995.1 - 1.8e-07 30.6 2.3 0.021 14.4 0.1 3.4 3 0 0 3 3 3 2 Spa2 homology domain (SHD) of GIT GIT1_C PF12205.8 KOG97995.1 - 0.0036 17.4 0.0 0.0093 16.1 0.0 1.7 1 0 0 1 1 1 1 G protein-coupled receptor kinase-interacting protein 1 C term Cnl2_NKP2 PF09447.10 KOG97996.1 - 7.8e-12 45.2 0.5 4.1e-11 42.8 0.5 2.1 2 0 0 2 2 2 1 Cnl2/NKP2 family protein Telomerase_RBD PF12009.8 KOG97997.1 - 1.3e-30 106.2 3.9 1.3e-30 106.2 3.9 3.2 3 0 0 3 3 3 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 KOG97997.1 - 1.8e-10 40.7 3.6 2.9e-06 27.0 0.2 2.9 2 1 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) AIP3 PF03915.13 KOG97998.1 - 4.8e-136 454.1 19.0 4.8e-136 454.1 19.0 1.7 2 0 0 2 2 2 1 Actin interacting protein 3 Mus7 PF09462.10 KOG97999.1 - 4.8e-21 75.3 12.4 1.6e-18 67.0 7.8 2.2 1 1 1 2 2 2 2 Mus7/MMS22 family SNF5 PF04855.12 KOG98000.1 - 9.5e-46 156.5 2.8 1.6e-25 90.3 0.1 2.4 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 FXR_C3 PF16097.5 KOG98000.1 - 0.34 11.6 4.5 30 5.4 0.6 3.4 3 0 0 3 3 3 0 Fragile X-related 1 protein C-terminal region 3 zf-C3HC4_3 PF13920.6 KOG98001.1 - 2e-09 37.1 5.9 3.7e-09 36.3 5.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.24 KOG98001.1 - 3.1e-09 36.5 3.0 3.1e-09 36.5 3.0 1.8 2 0 0 2 2 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_2 PF13923.6 KOG98001.1 - 6.3e-08 32.3 8.5 1.4e-07 31.3 8.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOG98001.1 - 9.4e-08 31.9 10.1 1.7e-07 31.1 10.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KOG98001.1 - 4.3e-07 29.7 6.6 8e-07 28.8 6.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KOG98001.1 - 1.5e-05 25.2 7.3 2.9e-05 24.3 7.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf_CCCH_4 PF18345.1 KOG98001.1 - 1.9e-05 24.5 5.4 1.9e-05 24.5 5.4 2.2 2 0 0 2 2 2 1 Zinc finger domain zf-RING_UBOX PF13445.6 KOG98001.1 - 2.4e-05 24.2 8.2 5.2e-05 23.2 8.2 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KOG98001.1 - 6.6e-05 22.7 9.5 0.00012 21.9 9.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KOG98001.1 - 0.00023 21.2 8.1 0.00046 20.3 8.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-CCCH_4 PF18044.1 KOG98001.1 - 0.00054 19.7 1.8 0.00054 19.7 1.8 2.5 2 0 0 2 2 2 1 CCCH-type zinc finger zf-RING_10 PF16685.5 KOG98001.1 - 0.014 15.5 4.1 0.04 14.1 4.1 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-CCCH_2 PF14608.6 KOG98001.1 - 0.084 13.4 3.6 0.23 12.0 3.6 1.8 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger SpvD PF05563.12 KOG98001.1 - 0.085 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Salmonella plasmid virulence protein SpvD zf-P11 PF03854.14 KOG98001.1 - 0.12 12.1 2.9 0.24 11.1 2.9 1.4 1 0 0 1 1 1 0 P-11 zinc finger Pex24p PF06398.11 KOG98002.1 - 2.7e-92 309.6 9.2 4.8e-92 308.8 9.2 1.4 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Ribosomal_L38e PF01781.18 KOG98003.1 - 5.9e-27 93.6 2.2 6.5e-27 93.4 2.2 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family DUF4112 PF13430.6 KOG98004.1 - 3e-30 104.6 0.4 3.8e-30 104.2 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) HABP4_PAI-RBP1 PF04774.15 KOG98005.1 - 0.0093 16.8 0.2 0.013 16.3 0.2 1.3 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family CTP_transf_like PF01467.26 KOG98006.1 - 6.6e-32 110.7 0.0 9.7e-32 110.1 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like DUF2781 PF10914.8 KOG98007.1 - 0.016 15.6 0.2 0.022 15.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2781) fn3_2 PF16893.5 KOG98008.1 - 2e-37 127.2 0.7 4.7e-37 126.0 0.7 1.7 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 KOG98008.1 - 2.6e-24 84.9 0.1 4.3e-24 84.2 0.1 1.4 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus BRCT PF00533.26 KOG98008.1 - 2e-08 34.5 0.0 6.8e-08 32.8 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF3006 PF11213.8 KOG98008.1 - 0.00072 19.7 0.0 0.00072 19.7 0.0 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF3006) PTCB-BRCT PF12738.7 KOG98008.1 - 0.0013 18.7 0.0 0.0023 17.8 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain fn3 PF00041.21 KOG98008.1 - 0.0034 17.7 0.0 0.015 15.7 0.0 2.1 1 0 0 1 1 1 1 Fibronectin type III domain BRCT_2 PF16589.5 KOG98008.1 - 0.067 13.6 0.0 0.38 11.2 0.0 2.3 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 KOG98008.1 - 0.23 11.5 1.7 0.45 10.6 0.0 2.3 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Mid2 PF04478.12 KOG98009.1 - 5.6e-70 234.0 0.9 5.6e-70 234.0 0.9 3.4 1 1 3 4 4 4 1 Mid2 like cell wall stress sensor SKG6 PF08693.10 KOG98009.1 - 0.0062 15.9 2.2 0.0062 15.9 2.2 3.0 3 0 0 3 3 3 1 Transmembrane alpha-helix domain MRAP PF15183.6 KOG98009.1 - 0.037 14.0 0.0 0.12 12.3 0.0 1.9 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family Orf78 PF06024.12 KOG98009.1 - 0.45 10.8 0.0 0.45 10.8 0.0 3.1 3 0 0 3 3 3 0 Orf78 (ac78) Ribosomal_S25 PF03297.15 KOG98010.1 - 8.5e-39 131.8 6.1 9.5e-39 131.7 6.1 1.0 1 0 0 1 1 1 1 S25 ribosomal protein FtsK_gamma PF09397.10 KOG98010.1 - 0.0002 21.1 0.1 0.00029 20.5 0.1 1.3 1 0 0 1 1 1 1 Ftsk gamma domain EAP30 PF04157.16 KOG98010.1 - 0.035 13.4 0.0 0.041 13.2 0.0 1.1 1 0 0 1 1 1 0 EAP30/Vps36 family HTH_CodY PF08222.11 KOG98010.1 - 0.052 13.1 0.1 0.08 12.5 0.1 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain Ran_BP1 PF00638.18 KOG98011.1 - 1.2e-39 135.3 1.2 3.5e-39 133.8 0.1 2.3 2 0 0 2 2 2 1 RanBP1 domain NUP50 PF08911.11 KOG98011.1 - 1.2e-13 51.5 3.1 1.2e-13 51.5 3.1 4.2 3 1 0 3 3 3 1 NUP50 (Nucleoporin 50 kDa) VGPC1_C PF16799.5 KOG98011.1 - 0.2 11.6 0.4 0.45 10.5 0.4 1.6 1 0 0 1 1 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 MA3 PF02847.17 KOG98012.1 - 4.3e-34 116.9 1.1 2.4e-33 114.5 0.3 2.5 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 KOG98012.1 - 2.5e-24 86.1 2.4 2.5e-24 86.1 2.4 2.1 2 0 0 2 2 2 1 MIF4G domain DUF1497 PF07384.11 KOG98012.1 - 0.042 14.3 1.3 5.6 7.5 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1497) WH2 PF02205.20 KOG98013.1 - 5.2e-15 54.7 0.2 4.9e-10 38.9 0.2 2.6 2 0 0 2 2 2 2 WH2 motif Ribosomal_L10 PF00466.20 KOG98014.1 - 5.3e-25 87.5 0.2 9.2e-25 86.7 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.19 KOG98014.1 - 3.3e-21 75.7 2.9 6.8e-21 74.7 1.3 2.1 2 0 0 2 2 2 1 60s Acidic ribosomal protein RL10P_insert PF17777.1 KOG98014.1 - 1.5e-20 72.9 0.0 2.4e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Glucan_synthase PF02364.15 KOG98016.1 - 0 1342.6 0.0 0 1342.2 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 KOG98016.1 - 1e-43 148.7 0.2 3.2e-43 147.2 0.2 1.9 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 GP24_25 PF17388.2 KOG98016.1 - 0.2 11.6 0.1 0.47 10.4 0.1 1.6 1 0 0 1 1 1 0 Tail assembly gene products 24 & 25 DUF3671 PF12420.8 KOG98016.1 - 0.92 9.6 0.0 0.92 9.6 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function Glyco_hydro_72 PF03198.14 KOG98017.1 - 5.9e-139 462.7 1.2 7.9e-139 462.3 1.2 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 KOG98017.1 - 9.1e-17 61.5 1.7 9.1e-17 61.5 1.7 2.6 2 0 0 2 2 2 1 X8 domain 6PF2K PF01591.18 KOG98018.1 - 6.3e-77 257.8 1.1 9e-77 257.3 1.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KOG98018.1 - 1.6e-18 67.1 0.0 2.9e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 KOG98018.1 - 0.0082 16.3 0.0 0.023 14.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain HEAT PF02985.22 KOG98020.1 - 8.5e-16 56.7 17.7 0.0063 16.7 0.0 10.9 14 0 0 14 14 12 3 HEAT repeat IBN_N PF03810.19 KOG98020.1 - 6.9e-13 48.3 3.8 1.9e-11 43.7 1.9 3.9 3 1 0 3 3 3 1 Importin-beta N-terminal domain HEAT_EZ PF13513.6 KOG98020.1 - 3.8e-11 43.2 11.7 2.1e-06 28.1 0.0 9.2 10 2 1 11 11 11 1 HEAT-like repeat Cnd1 PF12717.7 KOG98020.1 - 3.4e-08 33.7 5.1 0.21 11.6 0.0 5.4 3 2 2 6 6 6 3 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 KOG98020.1 - 2.8e-07 30.6 4.8 0.046 13.6 0.0 5.1 3 2 2 5 5 5 1 Domain of unknown function (DUF3385) HEAT_2 PF13646.6 KOG98020.1 - 3.3e-07 30.6 5.8 0.1 13.0 0.0 6.9 5 2 4 9 9 9 3 HEAT repeats RICTOR_V PF14668.6 KOG98020.1 - 0.00034 20.8 0.1 0.46 10.7 0.0 3.9 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 CLASP_N PF12348.8 KOG98020.1 - 0.00092 18.8 2.2 0.99 8.9 0.0 4.7 4 1 1 5 5 5 1 CLASP N terminal RIX1 PF08167.12 KOG98020.1 - 0.0038 17.0 0.6 1.5 8.5 0.1 3.9 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis Arm PF00514.23 KOG98020.1 - 0.0041 17.1 5.7 1.3 9.1 0.0 5.5 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 KOG98020.1 - 0.035 14.7 0.7 40 4.9 0.0 4.8 4 1 1 5 5 5 0 Vacuolar 14 Fab1-binding region Sec7_N PF12783.7 KOG98020.1 - 0.051 13.5 0.3 13 5.7 0.0 3.2 3 1 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3347 PF11827.8 KOG98020.1 - 0.11 12.7 2.3 0.41 10.8 0.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3347) Telomere_reg-2 PF10193.9 KOG98020.1 - 1.5 9.3 4.8 8.2 6.9 0.0 4.1 3 2 0 4 4 4 0 Telomere length regulation protein Mito_carr PF00153.27 KOG98021.1 - 5e-55 183.4 0.4 1.3e-18 66.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOG98021.1 - 0.081 12.1 0.1 0.4 9.8 0.0 2.1 3 0 0 3 3 3 0 Gammaproteobacterial serine protease ORMDL PF04061.14 KOG98022.1 - 3.1e-51 172.8 6.7 3.7e-51 172.5 6.7 1.1 1 0 0 1 1 1 1 ORMDL family DUF4271 PF14093.6 KOG98022.1 - 0.00036 20.5 1.5 0.00041 20.3 1.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4271) CN_hydrolase PF00795.22 KOG98023.1 - 4e-68 229.6 0.0 4.5e-68 229.4 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF1415 PF07209.12 KOG98023.1 - 0.038 13.7 0.0 0.06 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1415) SBBP PF06739.11 KOG98023.1 - 0.041 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Beta-propeller repeat LRR_4 PF12799.7 KOG98024.1 - 1.2e-07 31.9 9.0 0.015 15.7 0.3 5.2 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOG98024.1 - 7.1e-05 22.5 2.5 0.23 11.2 0.2 4.9 4 0 0 4 4 4 1 Leucine rich repeat LRR_1 PF00560.33 KOG98024.1 - 0.0063 16.9 5.3 37 5.4 0.1 6.7 4 2 1 5 5 5 0 Leucine Rich Repeat F-box-like PF12937.7 KOG98024.1 - 0.015 15.2 0.1 3.1 7.8 0.0 2.8 2 0 0 2 2 2 0 F-box-like LRR_6 PF13516.6 KOG98024.1 - 0.084 13.0 6.5 55 4.2 0.1 5.3 5 0 0 5 5 5 0 Leucine Rich repeat GPS2_interact PF15784.5 KOG98024.1 - 0.92 10.0 2.9 0.45 11.0 0.6 1.6 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain TAL_FSA PF00923.19 KOG98026.1 - 2.8e-100 335.4 0.3 3.3e-100 335.1 0.3 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Corona_NS2 PF04753.12 KOG98026.1 - 0.037 14.6 0.0 0.12 13.0 0.0 1.8 2 0 0 2 2 2 0 Coronavirus non-structural protein NS2 IlvN PF07991.12 KOG98027.1 - 9.6e-46 155.4 0.0 1.3e-45 154.9 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 KOG98027.1 - 3.5e-40 137.6 0.0 6.4e-40 136.8 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain Bromodomain PF00439.25 KOG98029.1 - 3.7e-26 91.0 3.5 7.2e-13 48.4 0.2 3.0 3 0 0 3 3 3 2 Bromodomain BAH PF01426.18 KOG98029.1 - 1e-24 86.7 0.1 3.2e-24 85.1 0.0 1.9 2 0 0 2 2 2 1 BAH domain Lyase_1 PF00206.20 KOG98030.1 - 8.6e-25 87.8 0.0 1.6e-24 86.9 0.0 1.4 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 KOG98030.1 - 1e-17 64.4 0.1 5.3e-17 62.1 0.0 2.2 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus DUF1331 PF07048.11 KOG98030.1 - 0.07 12.8 0.1 0.16 11.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) VPS38 PF17649.1 KOG98031.1 - 1.9e-168 560.8 21.6 2.1e-168 560.6 21.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 38 PriC PF07445.12 KOG98031.1 - 0.0094 15.9 1.4 0.019 14.9 1.4 1.5 1 0 0 1 1 1 1 Primosomal replication protein priC APG6 PF04111.12 KOG98031.1 - 0.014 15.4 0.2 0.014 15.4 0.2 1.7 2 0 0 2 2 2 0 Apg6 BARA domain Atg14 PF10186.9 KOG98031.1 - 0.027 13.6 13.3 0.7 8.9 13.3 2.2 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2408 PF10303.9 KOG98031.1 - 0.17 12.5 5.1 0.57 10.7 5.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) Metallophos PF00149.28 KOG98032.1 - 1.6e-20 74.5 0.4 4e-20 73.2 0.2 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOG98032.1 - 0.0015 18.7 0.0 0.032 14.4 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MoaF_C PF17409.2 KOG98032.1 - 0.054 13.2 0.0 4.2 7.1 0.0 2.4 2 0 0 2 2 2 0 MoaF C-terminal domain PGA_cap PF09587.10 KOG98032.1 - 0.18 11.2 0.1 1.2 8.6 0.0 2.2 3 0 0 3 3 3 0 Bacterial capsule synthesis protein PGA_cap Pkinase PF00069.25 KOG98034.1 - 6.6e-67 225.6 0.3 1.2e-59 201.9 0.0 2.6 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98034.1 - 2.2e-49 168.1 0.6 4.6e-47 160.5 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Ras_bdg_2 PF14847.6 KOG98034.1 - 6.5e-35 119.5 0.2 2e-34 117.9 0.2 1.9 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.17 KOG98034.1 - 6.7e-12 45.3 0.9 2.1e-11 43.8 0.0 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KOG98034.1 - 9.6e-08 32.4 0.0 3.2e-07 30.7 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 KOG98034.1 - 4e-06 26.4 0.0 0.00071 19.0 0.0 2.8 2 1 1 3 3 3 1 Kinase-like SAM_4 PF18017.1 KOG98034.1 - 0.0038 17.2 0.1 0.028 14.4 0.0 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 KOG98034.1 - 0.0071 15.2 4.7 0.042 12.6 4.7 2.1 1 1 0 1 1 1 1 Fungal protein kinase DUF2828 PF11443.8 KOG98034.1 - 2.3 6.2 11.5 4.9 5.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) PIN_4 PF13638.6 KOG98035.1 - 0.012 15.9 0.0 0.04 14.2 0.0 1.9 1 1 0 1 1 1 0 PIN domain DUF2462 PF09495.10 KOG98036.1 - 8.4e-14 52.1 11.0 1.2e-13 51.5 11.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2462) Glutaredoxin PF00462.24 KOG98037.1 - 2.9e-05 24.2 0.0 5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF953 PF06110.11 KOG98037.1 - 0.0027 17.3 0.9 0.0037 16.9 0.9 1.4 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.6 KOG98037.1 - 0.0076 16.0 0.0 0.0092 15.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Transp_cyt_pur PF02133.15 KOG98038.1 - 2.8e-09 36.2 5.9 3.2e-09 36.1 5.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Transp_cyt_pur PF02133.15 KOG98039.1 - 1.3e-67 228.5 38.3 1.9e-67 228.0 38.3 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin F-box-like PF12937.7 KOG98040.1 - 5.7e-06 26.1 3.3 1.5e-05 24.8 3.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOG98040.1 - 0.00068 19.4 2.3 0.0018 18.1 2.3 1.8 1 0 0 1 1 1 1 F-box domain HSP70 PF00012.20 KOG98041.1 - 3.6e-212 705.8 12.6 4.2e-212 705.6 12.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOG98041.1 - 1.2e-18 67.0 1.6 9.2e-17 60.8 0.6 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 KOG98041.1 - 0.011 15.4 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Raco_middle PF17651.1 KOG98041.1 - 0.19 11.4 1.0 3.3 7.4 0.0 2.8 3 0 0 3 3 3 0 RACo middle region P21-Arc PF04062.14 KOG98042.1 - 2.2e-57 193.9 0.0 2.6e-57 193.7 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit CNH PF00780.22 KOG98043.1 - 1.9e-81 273.7 1.1 2.5e-81 273.3 0.3 1.7 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 KOG98043.1 - 2.5e-40 137.7 0.0 2.5e-40 137.7 0.0 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain RhoGEF PF00621.20 KOG98043.1 - 2.5e-31 109.3 0.3 1.4e-30 106.9 0.0 2.4 2 0 0 2 2 2 1 RhoGEF domain DEP PF00610.21 KOG98043.1 - 4.4e-14 52.3 0.0 1.2e-13 50.9 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ELO PF01151.18 KOG98044.1 - 2.8e-61 207.2 27.5 3.5e-61 206.9 27.5 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family CENP-B_dimeris PF09026.10 KOG98045.1 - 0.0018 18.6 2.1 0.0057 17.0 2.1 1.8 1 0 0 1 1 1 1 Centromere protein B dimerisation domain DUF507 PF04368.13 KOG98045.1 - 0.022 14.7 0.2 0.076 12.9 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF507) DUF4611 PF15387.6 KOG98045.1 - 2.2 8.6 5.9 8.5 6.7 4.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) zf-C2H2_4 PF13894.6 KOG98046.1 - 4.4e-07 30.2 22.2 0.00051 20.6 2.6 4.9 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOG98046.1 - 0.0013 18.7 1.4 0.0013 18.7 1.4 3.4 4 0 0 4 4 3 1 C2H2-type zinc finger zf-C2H2 PF00096.26 KOG98046.1 - 0.0021 18.4 4.3 0.0021 18.4 4.3 4.8 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KOG98046.1 - 0.0037 17.5 4.3 0.059 13.7 0.1 3.4 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding Zn-C2H2_12 PF18112.1 KOG98046.1 - 0.024 15.1 0.3 9.3 6.8 0.1 2.9 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-SNAP50_C PF12251.8 KOG98046.1 - 0.025 14.3 7.2 0.04 13.6 0.9 2.2 2 0 0 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal zf-C3HC4_3 PF13920.6 KOG98046.1 - 0.033 14.1 5.9 2 8.3 0.3 3.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-H2C2_2 PF13465.6 KOG98046.1 - 0.045 14.2 4.0 0.045 14.2 4.0 4.8 4 1 1 5 5 5 0 Zinc-finger double domain zf-Di19 PF05605.12 KOG98046.1 - 0.23 11.8 9.1 0.2 12.0 4.0 3.3 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_2 PF13639.6 KOG98046.1 - 0.65 10.4 6.6 26 5.3 0.7 3.7 3 0 0 3 3 3 0 Ring finger domain Prok-RING_4 PF14447.6 KOG98046.1 - 0.71 9.8 5.6 5.4 7.0 0.2 3.0 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 Rad50_zn_hook PF04423.14 KOG98046.1 - 0.71 9.7 2.6 2.2 8.2 0.1 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING_5 PF14634.6 KOG98046.1 - 0.76 9.8 6.1 13 5.9 0.4 3.4 3 0 0 3 3 3 0 zinc-RING finger domain zinc_ribbon_9 PF14369.6 KOG98046.1 - 1 9.6 3.9 2.2 8.6 0.2 3.0 3 0 0 3 3 3 0 zinc-ribbon Prok-RING_1 PF14446.6 KOG98046.1 - 1.3 9.0 5.1 6.8 6.7 0.0 3.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-C2HC_2 PF13913.6 KOG98046.1 - 1.7 8.7 11.6 2.8 8.0 0.9 3.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type PSY3 PF16836.5 KOG98047.1 - 1.4e-74 250.3 1.3 1.6e-74 250.1 1.3 1.0 1 0 0 1 1 1 1 Shu complex component Psy3, DNA-binding description FBPase PF00316.20 KOG98048.1 - 9.6e-86 286.1 0.2 1.2e-85 285.7 0.2 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Ribosomal_S12 PF17487.2 KOG98049.1 - 0.42 11.4 7.5 0.63 10.8 7.5 1.2 1 0 0 1 1 1 0 Ribosomal protein S12 SecY PF00344.20 KOG98050.1 - 1.5e-63 214.9 15.6 1.9e-63 214.5 15.6 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 KOG98050.1 - 8.1e-18 64.0 0.2 5.5e-17 61.3 0.2 2.6 1 0 0 1 1 1 1 Plug domain of Sec61p Claudin_3 PF06653.11 KOG98050.1 - 0.13 12.2 7.1 1.1 9.2 0.0 3.1 3 0 0 3 3 3 0 Tight junction protein, Claudin-like SdpI PF13630.6 KOG98050.1 - 2.6 8.2 7.7 0.17 12.0 0.3 2.9 3 0 0 3 3 3 0 SdpI/YhfL protein family Cation_ATPase_C PF00689.21 KOG98050.1 - 2.7 7.7 12.4 1.4 8.6 0.6 3.5 2 1 1 3 3 3 0 Cation transporting ATPase, C-terminus CRAL_TRIO PF00650.20 KOG98051.1 - 3.4e-42 143.9 0.1 6.1e-42 143.0 0.1 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KOG98051.1 - 2.3e-11 43.7 0.3 7.6e-11 42.0 0.0 2.0 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 KOG98051.1 - 0.00056 20.1 0.0 0.0011 19.2 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain SIR2 PF02146.17 KOG98051.1 - 0.11 12.4 0.0 6.7 6.6 0.0 2.4 2 0 0 2 2 2 0 Sir2 family tRNA-synt_1 PF00133.22 KOG98053.1 - 2.1e-52 178.2 4.0 9.5e-31 106.7 4.5 6.4 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 KOG98053.1 - 1.8e-38 131.9 0.0 3.2e-38 131.1 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 KOG98053.1 - 1.3e-32 113.0 0.6 2.2e-21 76.1 0.0 4.7 4 1 1 5 5 5 4 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 KOG98053.1 - 0.00017 21.0 0.0 0.099 12.0 0.0 2.7 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 KOG98053.1 - 0.00078 19.4 0.3 0.0019 18.2 0.3 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1d PF00750.19 KOG98053.1 - 0.0098 14.9 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (R) Med10 PF09748.9 KOG98053.1 - 0.08 12.9 0.1 0.52 10.3 0.0 2.2 2 0 0 2 2 2 0 Transcription factor subunit Med10 of Mediator complex zf-ribbon_3 PF13248.6 KOG98053.1 - 0.39 10.2 4.1 2.4 7.7 0.4 2.4 2 0 0 2 2 2 0 zinc-ribbon domain AAA_23 PF13476.6 KOG98054.1 - 5.7e-20 72.7 3.9 5.7e-20 72.7 3.9 5.6 3 2 2 5 5 5 1 AAA domain SMC_N PF02463.19 KOG98054.1 - 1.2e-16 60.8 38.8 9.4e-16 57.9 38.8 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 KOG98054.1 - 3.7e-09 36.8 33.7 3.7e-09 36.8 33.7 4.2 1 1 2 3 3 3 1 AAA ATPase domain AAA_21 PF13304.6 KOG98054.1 - 8.2e-05 22.6 16.4 0.001 19.0 0.3 3.4 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOG98054.1 - 0.00091 18.9 0.0 0.0023 17.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Ploopntkinase3 PF18751.1 KOG98054.1 - 0.07 13.0 0.6 0.18 11.7 0.0 1.9 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Filament PF00038.21 KOG98054.1 - 0.69 9.4 77.9 0.049 13.2 16.7 6.0 4 2 1 5 5 5 0 Intermediate filament protein SlyX PF04102.12 KOG98054.1 - 1.3 9.6 0.0 1.3 9.6 0.0 6.8 6 2 0 6 6 6 0 SlyX Mac PF12464.8 KOG98054.1 - 1.6 9.0 4.9 1.1 9.5 0.4 3.1 2 0 0 2 2 2 0 Maltose acetyltransferase DUF1664 PF07889.12 KOG98054.1 - 7.4 6.6 53.1 0.15 12.1 3.2 7.3 2 2 4 7 7 7 0 Protein of unknown function (DUF1664) IKI3 PF04762.12 KOG98055.1 - 0 1177.2 3.3 0 1177.2 3.3 2.0 3 0 0 3 3 3 1 IKI3 family ANAPC4_WD40 PF12894.7 KOG98055.1 - 0.00051 20.3 2.0 4.7 7.6 0.4 4.5 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_2 PF07719.17 KOG98055.1 - 0.09 12.9 12.8 7.6 6.9 0.2 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Ribosomal_L21e PF01157.18 KOG98055.1 - 0.11 12.3 1.0 1.5 8.8 0.1 3.1 3 0 0 3 3 3 0 Ribosomal protein L21e TPR_10 PF13374.6 KOG98055.1 - 0.15 11.9 4.2 36 4.4 0.3 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOG98055.1 - 0.28 11.5 11.5 2 8.8 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOG98055.1 - 0.39 10.6 6.8 6.8 6.7 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 KOG98055.1 - 2.1 8.5 15.0 5.9 7.0 0.7 4.8 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain SWC7 PF17330.2 KOG98056.1 - 9.5e-39 131.4 0.5 1.2e-38 131.1 0.5 1.1 1 0 0 1 1 1 1 SWR1 chromatin-remodelling complex, sub-unit Swc7 Vac14_Fig4_bd PF11916.8 KOG98057.1 - 5.5e-66 221.6 6.4 1.4e-65 220.3 6.4 1.8 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 KOG98057.1 - 1.2e-46 157.3 1.2 3.9e-38 130.0 0.1 4.6 4 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 KOG98057.1 - 3.9e-10 39.1 3.3 0.0014 18.8 0.0 6.7 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 KOG98057.1 - 6e-09 36.2 0.1 0.16 12.5 0.0 5.9 6 0 0 6 6 6 2 HEAT-like repeat CLASP_N PF12348.8 KOG98057.1 - 4.8e-06 26.3 4.8 0.037 13.6 1.8 4.3 4 0 0 4 4 4 1 CLASP N terminal RIX1 PF08167.12 KOG98057.1 - 0.00015 21.6 1.1 0.015 15.0 0.1 3.5 3 1 0 3 3 3 1 rRNA processing/ribosome biogenesis Cnd1 PF12717.7 KOG98057.1 - 0.00078 19.5 8.5 1.3 9.1 0.8 4.9 5 0 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.9 KOG98057.1 - 0.0011 19.2 4.8 0.13 12.4 0.4 3.4 4 0 0 4 4 4 2 Parkin co-regulated protein Arm PF00514.23 KOG98057.1 - 0.042 13.9 4.8 3.3 7.9 0.0 4.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Rep_fac_C PF08542.11 KOG98057.1 - 0.18 12.2 1.2 4.2 7.8 0.0 3.5 3 1 0 3 3 3 0 Replication factor C C-terminal domain RTP1_C1 PF10363.9 KOG98057.1 - 0.65 10.2 5.1 16 5.7 0.4 3.9 3 1 1 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 zf-C2H2_2 PF12756.7 KOG98058.1 - 8.1e-32 109.6 6.6 1.3e-29 102.5 2.4 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) Ribosomal_S14 PF00253.21 KOG98059.1 - 3.2e-15 55.6 3.3 3.5e-15 55.5 3.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF4428 PF14471.6 KOG98059.1 - 0.014 15.3 0.3 0.016 15.1 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) Peptidase_M16_M PF16187.5 KOG98060.1 - 1.1e-82 277.5 0.4 1.1e-82 277.5 0.4 2.1 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 KOG98060.1 - 3.3e-42 144.6 0.7 6.6e-23 81.7 0.0 3.2 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOG98060.1 - 4.4e-40 137.1 0.1 1.1e-39 135.8 0.1 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) CFEM PF05730.11 KOG98062.1 - 3.4e-09 36.6 13.7 8.2e-09 35.4 13.7 1.7 1 0 0 1 1 1 1 CFEM domain DUF936 PF06075.12 KOG98062.1 - 0.13 11.2 25.6 0.16 10.9 25.6 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Apt1 PF10351.9 KOG98062.1 - 0.54 9.1 24.4 0.69 8.7 24.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Menin PF05053.13 KOG98062.1 - 1.1 7.5 13.7 1.4 7.2 13.7 1.2 1 0 0 1 1 1 0 Menin RR_TM4-6 PF06459.12 KOG98062.1 - 1.3 8.8 8.0 1.5 8.5 8.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GREB1 PF15782.5 KOG98062.1 - 1.4 5.9 24.3 1.5 5.8 24.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SPX PF03105.19 KOG98062.1 - 3.1 7.6 23.6 3.9 7.3 23.6 1.2 1 0 0 1 1 1 0 SPX domain Tim54 PF11711.8 KOG98062.1 - 3.6 6.3 5.1 4.7 5.9 5.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PI3K_1B_p101 PF10486.9 KOG98062.1 - 4.5 4.9 22.8 6.4 4.4 22.8 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Presenilin PF01080.17 KOG98062.1 - 5.1 5.7 14.8 6.7 5.4 14.8 1.2 1 0 0 1 1 1 0 Presenilin SOBP PF15279.6 KOG98062.1 - 6.6 7.2 19.0 8.8 6.8 19.0 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Hid1 PF12722.7 KOG98062.1 - 7.5 4.5 18.5 8.6 4.3 18.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF572 PF04502.13 KOG98062.1 - 7.9 6.0 17.2 9.5 5.7 17.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Raftlin PF15250.6 KOG98062.1 - 8.9 4.9 13.8 11 4.7 13.8 1.1 1 0 0 1 1 1 0 Raftlin Arrestin_N PF00339.29 KOG98063.1 - 3.7e-06 27.0 0.0 8.1e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain ATP-synt_10 PF05176.14 KOG98064.1 - 2.2e-92 309.0 0.2 2.4e-92 308.8 0.2 1.0 1 0 0 1 1 1 1 ATP10 protein zf-RING_5 PF14634.6 KOG98065.1 - 1.5e-06 28.1 8.4 3.2e-06 27.0 8.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KOG98065.1 - 0.015 15.2 9.6 0.049 13.5 9.7 1.8 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Defensin_int PF17858.1 KOG98065.1 - 0.11 12.6 0.6 0.23 11.5 0.6 1.5 1 0 0 1 1 1 0 Platypus intermediate defensin-like peptide zf-C3HC4_3 PF13920.6 KOG98065.1 - 0.4 10.6 6.3 0.88 9.5 6.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) COX7C PF02935.16 KOG98066.1 - 9.2e-23 80.3 0.9 1.1e-22 80.1 0.9 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Sec1 PF00995.23 KOG98067.1 - 3e-82 277.7 13.7 3.6e-82 277.4 13.7 1.1 1 0 0 1 1 1 1 Sec1 family IL11 PF07400.11 KOG98067.1 - 0.2 11.3 2.0 5.7 6.6 0.0 2.9 3 0 0 3 3 3 0 Interleukin 11 AAA PF00004.29 KOG98068.1 - 1.2e-90 300.7 0.0 8.4e-44 149.2 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG98068.1 - 4.6e-24 83.9 0.2 1.5e-11 43.9 0.1 2.5 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 KOG98068.1 - 1.6e-13 50.7 0.0 8.9e-06 25.5 0.0 3.2 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOG98068.1 - 1.6e-11 44.9 0.3 2.1e-05 25.0 0.0 3.7 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 KOG98068.1 - 2.5e-11 43.8 0.1 3.3e-05 23.9 0.0 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KOG98068.1 - 1.3e-09 38.4 0.0 0.00015 22.0 0.0 2.9 2 2 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOG98068.1 - 1.7e-08 34.9 1.1 0.0022 18.3 0.0 4.3 2 2 1 3 3 3 1 AAA domain AAA_33 PF13671.6 KOG98068.1 - 1.3e-07 31.9 0.0 0.001 19.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 KOG98068.1 - 2.5e-07 30.8 0.0 0.00074 19.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 KOG98068.1 - 2e-06 27.3 0.0 0.0059 15.9 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain Rad17 PF03215.15 KOG98068.1 - 5.9e-06 26.3 0.0 0.0099 15.8 0.0 2.9 2 2 0 2 2 2 2 Rad17 P-loop domain RNA_helicase PF00910.22 KOG98068.1 - 1.1e-05 25.7 0.0 0.16 12.3 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_25 PF13481.6 KOG98068.1 - 5.5e-05 22.8 4.4 0.48 10.0 0.1 4.0 2 2 1 3 3 3 2 AAA domain Bac_DnaA PF00308.18 KOG98068.1 - 6e-05 23.0 0.0 0.0069 16.3 0.0 2.5 2 0 0 2 2 2 1 Bacterial dnaA protein Mg_chelatase PF01078.21 KOG98068.1 - 7.2e-05 22.3 0.1 0.17 11.2 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 KOG98068.1 - 9e-05 22.8 0.0 0.41 10.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 KOG98068.1 - 0.00028 20.9 0.0 0.2 11.7 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 KOG98068.1 - 0.00052 19.9 0.0 0.075 12.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 KOG98068.1 - 0.0009 18.8 0.0 1 8.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_3 PF07726.11 KOG98068.1 - 0.0025 17.7 0.0 2.8 7.8 0.0 2.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOG98068.1 - 0.0035 17.1 0.1 0.025 14.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOG98068.1 - 0.004 17.7 0.0 0.5 10.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 KOG98068.1 - 0.0042 17.2 0.0 0.55 10.3 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain NACHT PF05729.12 KOG98068.1 - 0.0057 16.6 0.4 0.11 12.4 0.0 3.0 3 0 0 3 3 3 1 NACHT domain IstB_IS21 PF01695.17 KOG98068.1 - 0.006 16.3 0.0 3.8 7.2 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein ABC_tran PF00005.27 KOG98068.1 - 0.012 16.1 0.1 0.22 12.1 0.0 2.3 2 0 0 2 2 2 0 ABC transporter ATPase PF06745.13 KOG98068.1 - 0.012 15.0 0.6 11 5.3 0.0 3.4 2 1 1 3 3 3 0 KaiC AAA_24 PF13479.6 KOG98068.1 - 0.013 15.3 0.0 0.8 9.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 KOG98068.1 - 0.018 14.8 0.0 0.15 11.7 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase CDC48_N PF02359.18 KOG98068.1 - 0.021 15.0 0.0 0.059 13.5 0.0 1.7 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), N-terminal domain ATPase_2 PF01637.18 KOG98068.1 - 0.03 14.2 0.0 11 5.8 0.0 3.2 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea Sigma54_activat PF00158.26 KOG98068.1 - 0.032 14.0 0.0 8.3 6.1 0.0 3.5 2 2 0 2 2 2 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 KOG98068.1 - 0.033 13.5 0.1 3 7.1 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin DUF815 PF05673.13 KOG98068.1 - 0.047 12.9 0.0 1.7 7.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MMR_HSR1_Xtn PF16897.5 KOG98068.1 - 0.13 12.3 0.5 5.1 7.2 0.0 3.1 3 0 0 3 3 3 0 C-terminal region of MMR_HSR1 domain AAA_19 PF13245.6 KOG98068.1 - 0.15 12.4 1.9 1 9.7 0.1 2.6 2 1 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.16 KOG98068.1 - 0.15 10.9 0.0 0.35 9.7 0.0 1.5 2 0 0 2 2 1 0 AFG1-like ATPase DSHCT PF08148.12 KOG98069.1 - 5.7e-46 156.2 0.1 1.5e-45 154.8 0.1 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 KOG98069.1 - 3.3e-41 140.3 0.3 8.3e-41 139.0 0.3 1.7 1 0 0 1 1 1 1 Ski2 N-terminal region DEAD PF00270.29 KOG98069.1 - 1.6e-20 73.6 0.0 3.5e-20 72.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.6 KOG98069.1 - 6.2e-15 55.9 3.6 6.2e-15 55.9 3.6 2.1 2 0 0 2 2 2 1 rRNA-processing arch domain ResIII PF04851.15 KOG98069.1 - 3.2e-07 30.5 0.0 8.7e-07 29.1 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOG98069.1 - 5.4e-07 29.9 0.0 3.1e-06 27.5 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOG98069.1 - 0.062 13.6 0.0 0.56 10.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain Y_phosphatase2 PF03162.13 KOG98069.1 - 1.7 8.2 4.2 1.8 8.1 1.6 2.4 2 0 0 2 2 2 0 Tyrosine phosphatase family Bromodomain PF00439.25 KOG98070.1 - 3.3e-38 129.6 0.8 3.5e-20 71.9 0.2 2.8 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 KOG98070.1 - 2e-20 72.7 1.2 5.6e-20 71.3 1.2 1.8 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRCC36_C PF18110.1 KOG98070.1 - 0.057 13.6 0.2 0.19 11.9 0.2 1.9 1 0 0 1 1 1 0 BRCC36 C-terminal helical domain Dus PF01207.17 KOG98071.1 - 7.5e-44 150.1 0.0 3.1e-33 115.2 0.0 2.4 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 KOG98071.1 - 1.9e-05 24.3 7.8 0.0015 18.2 0.7 2.8 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 KOG98071.1 - 0.014 15.3 0.5 0.014 15.3 0.5 2.8 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ALC PF17527.2 KOG98071.1 - 0.022 14.4 1.3 0.91 9.2 1.2 2.3 2 0 0 2 2 2 0 Phage ALC protein zf_CCCH_4 PF18345.1 KOG98071.1 - 0.025 14.6 1.2 0.025 14.6 1.2 2.6 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH_2 PF14608.6 KOG98071.1 - 0.19 12.2 3.9 0.65 10.5 0.2 2.7 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 KOG98071.1 - 3.2 8.5 9.9 4.6 8.0 0.4 2.9 2 1 1 3 3 3 0 Torus domain zf-C2H2 PF00096.26 KOG98072.1 - 0.00071 19.9 16.2 0.038 14.4 1.0 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG98072.1 - 0.00075 20.1 13.3 0.058 14.3 0.6 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 KOG98072.1 - 0.0035 17.5 0.2 0.0035 17.5 0.2 4.0 4 0 0 4 4 4 2 Aberrant zinc-finger zf-C2H2_jaz PF12171.8 KOG98072.1 - 0.023 15.0 3.6 3.2 8.2 0.1 3.4 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 KOG98072.1 - 0.054 13.9 16.5 0.17 12.3 1.0 3.5 3 0 0 3 3 3 0 Zinc-finger double domain CENP-B_dimeris PF09026.10 KOG98072.1 - 4.5 7.7 16.5 14 6.2 16.5 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Insulin_TMD PF17870.1 KOG98073.1 - 0.052 13.6 0.5 0.16 12.1 0.5 1.9 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Dus PF01207.17 KOG98074.1 - 2.2e-88 296.3 0.0 2.7e-88 296.0 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) ComA PF02679.15 KOG98074.1 - 0.19 11.2 0.0 0.49 9.8 0.0 1.6 2 0 0 2 2 2 0 (2R)-phospho-3-sulfolactate synthase (ComA) DHDPS PF00701.22 KOG98074.1 - 0.23 10.2 0.0 2.4 6.8 0.0 2.0 2 0 0 2 2 2 0 Dihydrodipicolinate synthetase family Ribosomal_L31e PF01198.19 KOG98075.1 - 0.00011 22.4 0.1 0.00011 22.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L31e DUF4050 PF13259.6 KOG98076.1 - 1.4e-09 38.6 19.5 1.1e-08 35.6 0.1 3.3 1 1 2 3 3 3 2 Protein of unknown function (DUF4050) AAR2 PF05282.11 KOG98076.1 - 0.042 13.3 4.1 0.049 13.0 4.1 1.2 1 0 0 1 1 1 0 AAR2 protein KAsynt_C_assoc PF16197.5 KOG98076.1 - 0.11 13.0 0.3 0.21 12.1 0.3 1.5 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension FYTT PF07078.11 KOG98077.1 - 0.15 11.3 0.0 0.18 11.1 0.0 1.1 1 0 0 1 1 1 0 Forty-two-three protein Utp21 PF04192.12 KOG98078.1 - 4.4e-78 262.0 0.3 6.7e-78 261.4 0.3 1.3 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 KOG98078.1 - 1.7e-19 69.9 0.0 2.9e-05 24.3 0.0 6.3 3 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOG98078.1 - 1.8e-13 50.7 17.2 7.5e-07 29.8 0.3 8.4 8 0 0 8 8 8 3 WD domain, G-beta repeat eIF2A PF08662.11 KOG98078.1 - 0.00019 21.4 0.2 1.5 8.6 0.0 3.7 2 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 KOG98078.1 - 0.0002 21.0 0.0 0.0032 17.1 0.0 2.8 2 1 1 3 3 3 1 PQQ-like domain Cytochrom_D1 PF02239.16 KOG98078.1 - 0.047 12.2 0.0 0.97 7.9 0.0 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain SGL PF08450.12 KOG98078.1 - 0.057 13.0 0.4 8.9 5.8 0.0 4.2 4 1 1 5 5 5 0 SMP-30/Gluconolactonase/LRE-like region Alpha-amyl_C PF09071.10 KOG98078.1 - 0.15 11.9 0.1 0.8 9.6 0.0 2.2 2 0 0 2 2 2 0 Alpha-amylase, C terminal His_Phos_2 PF00328.22 KOG98079.1 - 3.1e-141 471.2 0.2 4.4e-141 470.7 0.2 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 KOG98079.1 - 7e-39 131.9 0.1 1.8e-38 130.5 0.1 1.8 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 KOG98079.1 - 3.7e-08 33.2 0.0 8.6e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Ctr PF04145.15 KOG98080.1 - 6.8e-36 124.1 0.4 9.4e-36 123.7 0.4 1.2 1 0 0 1 1 1 1 Ctr copper transporter family DUF3010 PF11215.8 KOG98080.1 - 0.18 12.1 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3010) DUF2530 PF10745.9 KOG98080.1 - 0.51 10.6 2.6 1.1 9.6 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) SRR1 PF07985.12 KOG98081.1 - 1.5e-15 57.0 0.0 2.5e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 SRR1 SUR7 PF06687.12 KOG98082.1 - 1.7e-07 31.1 22.3 6.4e-06 26.0 22.3 3.2 1 1 0 1 1 1 1 SUR7/PalI family Nitr_red_bet_C PF14711.6 KOG98082.1 - 0.11 12.2 0.5 4 7.2 0.0 3.0 3 0 0 3 3 3 0 Respiratory nitrate reductase beta C-terminal DUF935 PF06074.12 KOG98082.1 - 2.4 6.8 5.4 3.3 6.3 0.4 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF935) SUR7 PF06687.12 KOG98083.1 - 3.5e-43 147.7 14.3 4.2e-43 147.5 14.3 1.0 1 0 0 1 1 1 1 SUR7/PalI family DUF4995 PF16386.5 KOG98083.1 - 0.25 11.4 0.8 17 5.5 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF2207 PF09972.9 KOG98083.1 - 4.4 5.9 6.7 0.54 9.0 2.2 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Fig1 PF12351.8 KOG98083.1 - 6.9 6.5 12.7 1 9.3 8.1 1.9 1 1 1 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Cation_ATPase_C PF00689.21 KOG98083.1 - 7.9 6.1 12.2 20 4.9 12.2 1.7 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus Vps36_ESCRT-II PF11605.8 KOG98084.1 - 2.2e-31 107.9 1.5 3.8e-31 107.1 0.0 2.3 3 0 0 3 3 3 1 Vacuolar protein sorting protein 36 Vps36 EAP30 PF04157.16 KOG98084.1 - 8.9e-24 84.1 0.2 1.6e-23 83.2 0.2 1.4 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36-NZF-N PF16988.5 KOG98084.1 - 9.9e-21 72.9 4.4 9.9e-21 72.9 4.4 2.8 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 KOG98084.1 - 0.035 14.2 6.1 0.31 11.1 0.1 2.6 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger DZR PF12773.7 KOG98084.1 - 0.13 12.3 4.7 0.35 10.9 0.3 2.4 2 1 0 2 2 2 0 Double zinc ribbon Rubredoxin PF00301.20 KOG98084.1 - 2.1 8.4 4.0 3.5 7.7 0.2 2.7 2 1 1 3 3 3 0 Rubredoxin zinc_ribbon_15 PF17032.5 KOG98084.1 - 5.8 7.7 7.1 14 6.5 6.7 2.0 1 1 0 1 1 1 0 zinc-ribbon family CDC73_C PF05179.14 KOG98085.1 - 1.4e-56 190.5 1.4 2.1e-56 189.9 1.4 1.3 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal OB_NTP_bind PF07717.16 KOG98086.1 - 8.8e-19 67.7 0.0 2.3e-18 66.3 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KOG98086.1 - 4.6e-16 59.1 0.1 2.1e-15 57.0 0.1 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RWD PF05773.22 KOG98086.1 - 7.9e-14 51.9 1.9 7.9e-14 51.9 1.9 2.5 2 0 0 2 2 2 1 RWD domain DEAD PF00270.29 KOG98086.1 - 4.8e-10 39.5 1.8 1.1e-09 38.3 1.8 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase HA2 PF04408.23 KOG98086.1 - 1.1e-05 25.6 0.0 1.1e-05 25.6 0.0 2.7 3 0 0 3 3 2 1 Helicase associated domain (HA2) AAA_19 PF13245.6 KOG98086.1 - 4.9e-05 23.7 0.7 0.00012 22.5 0.7 1.6 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 KOG98086.1 - 0.00012 21.6 1.5 0.00042 19.8 1.5 1.9 1 1 0 1 1 1 1 PhoH-like protein ResIII PF04851.15 KOG98086.1 - 0.00031 20.8 0.2 0.00031 20.8 0.2 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOG98086.1 - 0.00045 20.5 0.7 0.0036 17.6 0.2 2.7 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 KOG98086.1 - 0.00069 18.8 0.1 0.002 17.3 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 KOG98086.1 - 0.0017 18.1 0.2 0.0033 17.2 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 KOG98086.1 - 0.0031 17.2 0.0 0.0066 16.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain NACHT PF05729.12 KOG98086.1 - 0.0051 16.7 0.1 0.024 14.6 0.1 2.2 1 0 0 1 1 1 1 NACHT domain FtsK_SpoIIIE PF01580.18 KOG98086.1 - 0.012 15.0 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_25 PF13481.6 KOG98086.1 - 0.015 14.9 0.0 0.035 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 KOG98086.1 - 0.016 15.7 0.0 0.016 15.7 0.0 4.3 4 1 0 4 4 2 0 AAA domain AAA_7 PF12775.7 KOG98086.1 - 0.022 14.3 0.9 0.046 13.2 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 KOG98086.1 - 0.031 13.6 3.8 0.036 13.4 0.0 2.7 3 0 0 3 3 3 0 KaiC ABC_tran PF00005.27 KOG98086.1 - 0.078 13.5 0.9 0.34 11.4 0.0 2.6 2 1 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 KOG98086.1 - 0.11 12.9 0.1 0.36 11.2 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain Sigma54_activat PF00158.26 KOG98086.1 - 0.15 11.7 0.0 0.38 10.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 KOG98086.1 - 0.2 11.7 1.4 3.6 7.6 0.3 3.3 2 1 0 2 2 2 0 AAA domain Amidohydro_2 PF04909.14 KOG98087.1 - 3.1e-05 23.9 0.6 4.9e-05 23.3 0.0 1.6 2 1 0 2 2 2 1 Amidohydrolase Proteasom_Rpn13 PF04683.13 KOG98088.1 - 1.6e-20 73.4 0.0 2.3e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor DHR-2 PF06920.13 KOG98089.1 - 1.8e-44 152.3 0.1 4.7e-44 150.9 0.1 1.7 1 1 0 1 1 1 1 Dock homology region 2 ARTD15_N PF18084.1 KOG98089.1 - 0.16 12.3 0.6 1.9 8.8 0.1 3.0 2 0 0 2 2 2 0 ARTD15 N-terminal domain APG17 PF04108.12 KOG98090.1 - 3.1e-87 293.3 18.4 3.5e-87 293.1 18.4 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 DUF948 PF06103.11 KOG98090.1 - 0.021 15.0 20.1 0.84 9.9 0.6 6.0 3 1 3 6 6 6 0 Bacterial protein of unknown function (DUF948) ApoB100_C PF12491.8 KOG98090.1 - 0.022 14.7 0.1 0.92 9.5 0.0 3.1 2 0 0 2 2 2 0 Apolipoprotein B100 C terminal DUF2935 PF11155.8 KOG98090.1 - 0.086 13.2 6.1 0.76 10.1 1.9 3.7 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) DUF2258 PF10015.9 KOG98090.1 - 0.5 10.5 4.9 1.8 8.7 0.1 3.7 3 1 1 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2258) Baculo_PEP_C PF04513.12 KOG98090.1 - 1.1 9.3 21.9 1.3 9.1 0.4 4.7 2 1 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus FTO_CTD PF12934.7 KOG98090.1 - 1.1 8.9 4.5 6.4 6.5 0.0 3.3 2 1 1 3 3 3 0 FTO C-terminal domain G-patch PF01585.23 KOG98091.1 - 1.4e-13 50.5 1.4 2.6e-13 49.6 1.4 1.5 1 0 0 1 1 1 1 G-patch domain GCFC PF07842.12 KOG98091.1 - 1.3e-08 34.8 2.2 2.4e-08 33.9 2.2 1.4 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein G-patch_2 PF12656.7 KOG98091.1 - 2.6e-05 24.2 0.2 6.3e-05 23.0 0.2 1.7 1 0 0 1 1 1 1 G-patch domain HAUS2 PF15003.6 KOG98091.1 - 0.049 13.4 1.7 0.1 12.3 1.7 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 2 DUF3741 PF12552.8 KOG98091.1 - 0.2 11.6 4.3 1.3 9.0 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3741) CNH PF00780.22 KOG98092.1 - 2.2e-15 57.0 1.5 1.2e-14 54.6 1.5 2.0 1 1 0 1 1 1 1 CNH domain RhoGEF PF00621.20 KOG98092.1 - 1.5e-07 31.8 0.1 4e-07 30.5 0.1 1.8 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 KOG98092.1 - 2.3e-05 24.5 0.6 8.5e-05 22.7 0.2 2.2 2 1 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 KOG98092.1 - 0.004 17.6 2.3 0.013 16.0 0.1 3.2 2 2 1 3 3 3 1 PH domain SRP9-21 PF05486.12 KOG98092.1 - 0.0041 17.5 0.1 0.016 15.6 0.1 2.0 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) PH_12 PF16457.5 KOG98092.1 - 0.076 13.6 0.3 5.1 7.6 0.1 2.8 2 0 0 2 2 2 0 Pleckstrin homology domain zf-RING_UBOX PF13445.6 KOG98093.1 - 3.8e-07 30.0 4.0 8.9e-07 28.8 4.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOG98093.1 - 2.4e-06 27.4 6.0 4.6e-06 26.5 6.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOG98093.1 - 2.6e-06 27.2 5.5 6.2e-06 26.0 5.5 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOG98093.1 - 4.5e-06 26.9 5.1 8.9e-06 26.0 5.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KOG98093.1 - 0.0005 19.9 6.9 0.0022 17.8 6.9 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOG98093.1 - 0.0011 18.7 7.5 0.07 13.0 4.3 2.4 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KOG98093.1 - 0.0055 16.5 2.3 0.0055 16.5 2.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KOG98093.1 - 0.011 15.8 6.6 0.034 14.3 6.6 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 KOG98093.1 - 0.24 11.2 4.6 0.74 9.6 4.6 1.9 1 0 0 1 1 1 0 RING-like zinc finger IBR PF01485.21 KOG98093.1 - 0.33 11.2 3.3 22 5.4 1.0 2.6 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zf-RING_10 PF16685.5 KOG98093.1 - 0.58 10.3 3.7 1.5 9.0 3.7 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 KOG98093.1 - 4.8 7.6 6.1 21 5.5 6.1 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain DUF1899 PF08953.11 KOG98094.1 - 1.2e-31 108.3 0.4 2.4e-31 107.4 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 KOG98094.1 - 2.9e-20 71.9 0.6 7.4e-20 70.6 0.6 1.7 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 KOG98094.1 - 7.8e-16 58.2 6.7 0.00047 20.9 0.0 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 KOG98094.1 - 4.2e-06 25.7 0.1 0.00015 20.5 0.0 2.3 1 1 1 2 2 2 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 KOG98094.1 - 1.7e-05 25.0 0.0 0.042 14.1 0.0 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOG98094.1 - 0.00022 21.2 0.1 0.11 12.4 0.0 2.7 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOG98094.1 - 0.027 13.5 0.0 1.2 8.0 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Exog_C PF18026.1 KOG98094.1 - 1.2 9.3 8.9 4.7 7.4 1.2 2.6 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain SEN1_N PF12726.7 KOG98095.1 - 1.6e-209 697.9 12.1 2.5e-209 697.3 12.1 1.3 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 KOG98095.1 - 3.5e-70 236.8 0.1 3.5e-70 236.8 0.1 3.4 3 0 0 3 3 3 2 AAA domain AAA_12 PF13087.6 KOG98095.1 - 1.4e-62 210.9 0.0 4.2e-62 209.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOG98095.1 - 1.6e-09 38.2 0.0 9.6e-09 35.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOG98095.1 - 2.9e-08 33.7 0.0 0.00043 20.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain UvrD-helicase PF00580.21 KOG98095.1 - 3.4e-08 33.4 9.9 9e-05 22.1 0.0 4.6 3 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 KOG98095.1 - 8.8e-05 22.4 0.0 0.1 12.3 0.0 3.5 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase FlxA PF14282.6 KOG98096.1 - 0.24 11.4 8.1 5.2 7.1 0.5 3.4 3 1 0 3 3 3 0 FlxA-like protein Nas2_N PF18265.1 KOG98096.1 - 0.31 11.0 8.8 3.2 7.7 0.1 4.5 4 1 1 5 5 5 0 Nas2 N_terminal domain Ribosomal_L29 PF00831.23 KOG98096.1 - 6.6 6.8 12.1 8.6 6.4 1.1 5.0 6 0 0 6 6 6 0 Ribosomal L29 protein IMPDH PF00478.25 KOG98097.1 - 1.1e-133 445.6 1.6 1.3e-133 445.3 1.6 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 KOG98097.1 - 2.8e-13 50.1 0.0 1.4e-05 25.4 0.0 2.5 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 KOG98097.1 - 1.4e-06 27.6 1.6 3.3e-06 26.4 1.6 1.5 1 1 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 KOG98097.1 - 8.3e-05 22.1 5.4 0.01 15.3 4.3 2.7 2 1 1 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.21 KOG98097.1 - 0.0004 19.9 0.9 0.016 14.7 0.1 2.3 1 1 1 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 KOG98097.1 - 0.073 12.4 0.2 0.19 11.0 0.2 1.6 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG YpsA PF06908.11 KOG98097.1 - 0.16 11.9 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family Metallophos PF00149.28 KOG98098.1 - 2.1e-31 110.1 0.0 3.7e-31 109.2 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase WGG PF10273.9 KOG98099.1 - 7.6e-29 100.2 0.5 7.6e-29 100.2 0.5 2.1 2 1 0 2 2 2 1 Pre-rRNA-processing protein TSR2 Vfa1 PF08432.10 KOG98099.1 - 0.0052 17.1 2.3 0.0086 16.4 2.3 1.3 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 DUF2457 PF10446.9 KOG98099.1 - 0.0085 15.3 11.5 0.011 14.9 11.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) PBP1_TM PF14812.6 KOG98099.1 - 0.054 13.9 11.9 0.12 12.8 11.9 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SDA1 PF05285.12 KOG98099.1 - 0.12 11.8 6.9 0.13 11.7 6.9 1.2 1 0 0 1 1 1 0 SDA1 GREB1 PF15782.5 KOG98099.1 - 0.13 9.4 1.0 0.16 9.0 1.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NOA36 PF06524.12 KOG98099.1 - 0.13 11.6 10.1 0.15 11.3 10.1 1.1 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 KOG98099.1 - 0.13 11.9 11.4 0.22 11.3 11.4 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 KOG98099.1 - 0.24 11.4 7.3 0.39 10.7 7.3 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 KOG98099.1 - 0.29 10.8 5.2 0.49 10.1 5.2 1.3 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 KOG98099.1 - 0.55 8.5 5.6 0.53 8.5 5.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 KOG98099.1 - 1.8 6.6 12.1 2.3 6.2 12.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 KOG98099.1 - 3 6.3 6.7 3.2 6.2 6.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CENP-B_dimeris PF09026.10 KOG98099.1 - 3.9 7.9 16.8 4.5 7.7 14.7 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Hid1 PF12722.7 KOG98100.1 - 2.2e-27 95.6 65.8 1.2e-18 66.7 14.4 4.9 2 2 0 2 2 2 2 High-temperature-induced dauer-formation protein RNR_inhib PF08591.10 KOG98101.1 - 0.00042 21.6 5.1 0.00044 21.5 0.1 2.7 2 1 1 3 3 3 1 Ribonucleotide reductase inhibitor DUF4376 PF14301.6 KOG98101.1 - 0.0037 17.6 1.7 0.0057 17.0 1.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4376) SAGA-Tad1 PF12767.7 KOG98101.1 - 0.012 15.4 1.1 0.013 15.3 1.1 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Aminotran_3 PF00202.21 KOG98102.1 - 1.2e-124 416.0 0.0 1.4e-124 415.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 KOG98102.1 - 0.0012 18.2 0.0 0.0036 16.6 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 KOG98102.1 - 0.0061 15.8 0.0 0.028 13.6 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class I and II LSM PF01423.22 KOG98103.1 - 5e-21 74.2 0.2 5.7e-21 74.0 0.2 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 KOG98103.1 - 0.082 13.1 0.0 0.33 11.1 0.0 1.8 1 1 1 2 2 2 0 RimP C-terminal SH3 domain TamB PF04357.13 KOG98103.1 - 0.12 11.6 0.0 0.13 11.5 0.0 1.0 1 0 0 1 1 1 0 TamB, inner membrane protein subunit of TAM complex MRP-L47 PF06984.13 KOG98104.1 - 4.7e-27 93.9 0.2 1.1e-26 92.8 0.2 1.6 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) TFA2_Winged_2 PF18121.1 KOG98104.1 - 0.052 13.3 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 Tup_N PF08581.10 KOG98104.1 - 0.17 12.2 1.9 3 8.2 0.4 2.3 2 0 0 2 2 2 0 Tup N-terminal Sec39 PF08314.11 KOG98105.1 - 1.4e-121 407.4 15.9 2.5e-121 406.5 15.9 1.4 1 0 0 1 1 1 1 Secretory pathway protein Sec39 Sirohm_synth_C PF14823.6 KOG98105.1 - 0.024 14.2 0.0 3.9 7.2 0.0 2.8 2 0 0 2 2 2 0 Sirohaem biosynthesis protein C-terminal FeoB_Cyto PF17910.1 KOG98105.1 - 0.15 12.7 1.1 0.38 11.3 0.2 2.1 2 0 0 2 2 2 0 FeoB cytosolic helical domain Ribosomal_S3Ae PF01015.18 KOG98106.1 - 3e-86 288.2 5.2 3.5e-86 287.9 5.2 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family DLP_helical PF18709.1 KOG98106.1 - 0.0091 15.2 0.8 0.014 14.7 0.8 1.2 1 0 0 1 1 1 1 Dynamin-like helical domain Abhydro_lipase PF04083.16 KOG98106.1 - 0.067 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region ISAV_HA PF06215.11 KOG98106.1 - 0.093 11.9 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Infectious salmon anaemia virus haemagglutinin SpoVIF PF14069.6 KOG98106.1 - 0.64 9.8 4.5 5.5 6.8 1.3 2.6 2 0 0 2 2 2 0 Stage VI sporulation protein F SUR7 PF06687.12 KOG98107.1 - 9.1e-11 41.8 8.9 1.3e-10 41.3 8.9 1.2 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 KOG98107.1 - 0.023 14.6 1.7 0.041 13.8 1.7 1.4 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Orf78 PF06024.12 KOG98107.1 - 0.13 12.6 0.7 0.4 11.0 0.7 1.8 1 0 0 1 1 1 0 Orf78 (ac78) Hexokinase_1 PF00349.21 KOG98108.1 - 1.4e-17 64.3 0.2 2e-17 63.8 0.2 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 KOG98108.1 - 2e-14 53.6 0.0 4e-13 49.4 0.0 2.5 2 1 0 2 2 2 1 Hexokinase Intron_maturas2 PF01348.21 KOG98108.1 - 0.037 14.0 0.0 7.8 6.5 0.0 2.8 2 0 0 2 2 2 0 Type II intron maturase Fumble PF03630.14 KOG98108.1 - 0.045 12.9 2.7 0.11 11.6 0.2 2.1 2 0 0 2 2 2 0 Fumble vATP-synt_AC39 PF01992.16 KOG98109.1 - 9e-110 367.3 1.7 1e-109 367.1 1.7 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit PPV_E2_C PF00511.17 KOG98109.1 - 0.28 11.4 1.1 0.63 10.3 0.5 1.8 2 0 0 2 2 2 0 E2 (early) protein, C terminal Ribosomal_L6e PF01159.19 KOG98110.1 - 2.5e-37 127.8 3.6 3.2e-37 127.5 3.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L6e FKBP_C PF00254.28 KOG98111.1 - 2.1e-28 98.5 0.2 8.7e-28 96.5 0.1 2.1 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 KOG98111.1 - 1.6e-23 83.2 2.5 1.6e-23 83.2 2.5 2.9 2 2 0 2 2 2 1 Nucleoplasmin-like domain Pex14_N PF04695.13 KOG98111.1 - 0.46 11.1 6.0 14 6.3 0.0 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CCSAP PF15748.5 KOG98111.1 - 4.2 7.5 27.1 1.8 8.7 12.7 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated SDA1 PF05285.12 KOG98111.1 - 4.2 6.7 58.1 2.3 7.5 33.9 2.1 2 0 0 2 2 2 0 SDA1 HMG-CoA_red PF00368.18 KOG98112.1 - 1.1e-141 472.2 0.2 1.4e-141 471.8 0.2 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 KOG98112.1 - 4.3e-42 143.6 2.1 4.3e-42 143.6 2.1 1.7 2 0 0 2 2 2 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 KOG98112.1 - 8.2e-09 35.5 9.5 2.3e-08 34.0 9.5 1.8 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Zn_clus PF00172.18 KOG98113.1 - 2.5e-08 33.9 11.1 4.6e-08 33.1 11.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CENP-B_dimeris PF09026.10 KOG98113.1 - 0.37 11.2 4.1 0.83 10.1 4.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PRP1_N PF06424.12 KOG98113.1 - 8.1 6.8 9.3 9.4 6.6 0.1 3.5 3 0 0 3 3 3 0 PRP1 splicing factor, N-terminal RGS PF00615.19 KOG98114.1 - 3.5e-20 72.4 0.7 9.2e-13 48.5 0.1 2.6 2 0 0 2 2 2 2 Regulator of G protein signaling domain DEP PF00610.21 KOG98114.1 - 8e-13 48.2 0.0 1.3e-10 41.2 0.0 2.5 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF1902 PF08972.11 KOG98114.1 - 0.044 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1902) Fmp27 PF10344.9 KOG98116.1 - 6.9e-118 395.0 48.7 1.8e-117 393.7 48.7 1.7 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Fmp27_WPPW PF10359.9 KOG98116.1 - 1.5e-117 393.4 4.7 1.5e-117 393.4 4.7 2.2 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Apt1 PF10351.9 KOG98116.1 - 2.3e-73 247.7 11.9 1.8e-47 162.3 6.7 2.9 1 1 1 2 2 2 2 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.9 KOG98116.1 - 3.6e-59 199.3 0.1 8.6e-59 198.1 0.1 1.7 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 KOG98116.1 - 6.7e-51 172.3 3.9 7.3e-50 168.9 4.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 KOG98116.1 - 1.4e-31 109.2 0.0 8.5e-31 106.7 0.0 2.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain PWWP PF00855.17 KOG98117.1 - 1e-17 64.3 1.9 1.6e-17 63.6 0.1 2.2 2 0 0 2 2 2 1 PWWP domain Putative_PNPOx PF01243.20 KOG98118.1 - 1.1e-12 48.0 0.0 3.7e-12 46.3 0.0 1.9 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase NBP1 PF08537.10 KOG98119.1 - 4.5e-83 279.5 26.6 9.8e-83 278.4 26.6 1.5 1 1 0 1 1 1 1 Fungal Nap binding protein NBP1 FPP PF05911.11 KOG98119.1 - 0.03 12.5 6.8 0.41 8.8 1.6 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Csm1_N PF18504.1 KOG98119.1 - 1.3 9.5 6.5 1.9 8.9 2.2 3.0 3 0 0 3 3 3 0 Csm1 N-terminal domain Dscam_C PF12355.8 KOG98119.1 - 2.1 9.3 6.9 17 6.4 2.4 2.8 2 1 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal PIG-U PF06728.13 KOG98120.1 - 8.5e-104 347.6 44.1 1e-103 347.3 44.1 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U SRP1_TIP1 PF00660.17 KOG98121.1 - 8.9e-27 93.1 0.0 1.2e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family Acetyltransf_3 PF13302.7 KOG98122.1 - 4.7e-15 56.5 0.0 7.1e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KOG98122.1 - 0.00087 19.5 0.0 0.0013 18.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOG98122.1 - 0.0032 17.7 0.0 0.0057 16.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Sugar_tr PF00083.24 KOG98125.1 - 5.2e-78 262.9 21.5 6e-78 262.7 21.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG98125.1 - 2.3e-24 86.0 33.8 2.3e-24 86.0 33.8 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily DHO_dh PF01180.21 KOG98126.1 - 2.2e-97 325.8 0.0 2.5e-97 325.7 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 KOG98126.1 - 1.3e-05 24.4 0.0 0.00031 19.9 0.0 2.1 2 0 0 2 2 2 1 FMN-dependent dehydrogenase Polysacc_deac_1 PF01522.21 KOG98126.1 - 0.0052 16.7 0.0 0.035 14.0 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide deacetylase Glu_synthase PF01645.17 KOG98126.1 - 0.042 13.0 0.0 0.064 12.4 0.0 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase IMPDH PF00478.25 KOG98126.1 - 0.13 11.3 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain FoP_duplication PF13865.6 KOG98127.1 - 6e-07 29.9 5.1 6e-07 29.9 5.1 1.8 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 RRM_1 PF00076.22 KOG98127.1 - 1.3e-06 28.1 0.0 1.9e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PUL PF08324.11 KOG98128.1 - 2.1e-42 145.3 0.1 3e-42 144.8 0.1 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 KOG98128.1 - 1.3e-40 138.2 0.3 3.3e-40 136.9 0.0 1.9 2 0 0 2 2 2 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 KOG98128.1 - 1.1e-27 95.7 17.1 5e-08 33.5 0.0 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat BBS2_Mid PF14783.6 KOG98128.1 - 1.2e-05 25.3 0.3 0.49 10.5 0.0 4.2 3 1 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 KOG98128.1 - 0.0026 17.2 0.8 1.4 8.2 0.1 2.9 2 1 2 4 4 4 2 WD40-like domain Syja_N PF02383.18 KOG98129.1 - 1.7e-83 280.6 1.0 2.3e-83 280.2 1.0 1.2 1 0 0 1 1 1 1 SacI homology domain IGPS PF00218.21 KOG98130.1 - 1.2e-96 322.8 0.0 1.5e-96 322.5 0.0 1.1 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase GATase PF00117.28 KOG98130.1 - 1.2e-51 175.2 0.0 1.9e-51 174.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 KOG98130.1 - 1.8e-09 37.7 0.2 7.8e-09 35.6 0.2 2.0 2 1 0 2 2 2 1 Peptidase C26 QRPTase_C PF01729.19 KOG98130.1 - 7e-05 22.7 0.1 0.00014 21.7 0.1 1.4 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain Peripla_BP_2 PF01497.18 KOG98130.1 - 0.026 14.1 0.0 0.058 12.9 0.0 1.5 1 0 0 1 1 1 0 Periplasmic binding protein LDcluster4 PF18306.1 KOG98130.1 - 0.043 13.4 0.1 0.09 12.4 0.1 1.4 1 0 0 1 1 1 0 SLOG cluster4 family RimM PF01782.18 KOG98130.1 - 0.11 12.8 0.0 0.31 11.3 0.0 1.8 1 0 0 1 1 1 0 RimM N-terminal domain His_biosynth PF00977.21 KOG98130.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein ThiF PF00899.21 KOG98131.1 - 4.4e-113 376.6 0.0 4.3e-77 258.8 0.0 2.2 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 KOG98131.1 - 1.4e-88 297.1 2.0 2.3e-88 296.4 2.0 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 KOG98131.1 - 2e-33 115.0 0.1 4.7e-33 113.8 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 KOG98131.1 - 5.6e-27 93.7 0.2 1.4e-26 92.5 0.2 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 KOG98131.1 - 1.9e-24 85.7 0.1 4.3e-24 84.5 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle ABC_membrane PF00664.23 KOG98132.1 - 4.5e-108 361.0 37.9 5e-57 193.6 17.3 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOG98132.1 - 1.7e-62 209.9 0.1 6.5e-32 110.9 0.0 2.9 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOG98132.1 - 1.1e-18 67.5 0.3 8.7e-08 31.9 0.0 4.3 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOG98132.1 - 9.7e-08 31.7 0.5 0.0053 16.5 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.9 KOG98132.1 - 9.6e-07 27.9 0.0 0.045 12.5 0.0 2.9 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 KOG98132.1 - 2e-06 28.1 1.2 0.026 14.8 0.0 3.6 2 2 0 2 2 2 2 AAA domain DUF87 PF01935.17 KOG98132.1 - 2e-06 28.1 1.0 0.0018 18.4 0.0 3.2 3 1 0 3 3 3 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 KOG98132.1 - 1.1e-05 25.4 1.5 0.022 14.7 0.0 3.1 3 0 0 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 KOG98132.1 - 2e-05 25.1 0.5 0.021 15.2 0.0 3.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 KOG98132.1 - 0.00013 22.0 0.0 0.37 10.8 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KOG98132.1 - 0.00015 22.3 0.8 0.88 10.1 0.0 3.3 4 0 0 4 4 2 2 AAA domain MMR_HSR1 PF01926.23 KOG98132.1 - 0.0011 19.0 1.1 1.3 9.1 0.2 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase Zeta_toxin PF06414.12 KOG98132.1 - 0.0013 18.1 0.0 0.46 9.7 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin CbiA PF01656.23 KOG98132.1 - 0.0028 17.7 0.0 1.8 8.6 0.0 2.7 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.6 KOG98132.1 - 0.0036 17.0 0.0 1.4 8.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF3987 PF13148.6 KOG98132.1 - 0.0042 16.2 0.0 0.28 10.1 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) NB-ARC PF00931.22 KOG98132.1 - 0.0052 16.0 0.2 3 7.0 0.0 2.8 3 0 0 3 3 2 1 NB-ARC domain APS_kinase PF01583.20 KOG98132.1 - 0.0064 16.4 0.2 5.4 6.9 0.0 2.7 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_33 PF13671.6 KOG98132.1 - 0.012 15.8 0.0 3.2 7.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KOG98132.1 - 0.022 15.3 10.0 0.19 12.2 0.1 3.4 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 KOG98132.1 - 0.027 14.9 0.0 9.2 6.7 0.0 2.9 2 0 0 2 2 2 0 RNA helicase Ploopntkinase3 PF18751.1 KOG98132.1 - 0.033 14.1 0.0 12 5.8 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 PRK PF00485.18 KOG98132.1 - 0.036 13.8 0.1 2.4 7.8 0.0 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_30 PF13604.6 KOG98132.1 - 0.037 13.8 0.0 6.3 6.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.25 KOG98132.1 - 0.041 13.5 0.0 3.8 7.1 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_15 PF13175.6 KOG98132.1 - 0.043 13.5 11.1 0.18 11.5 3.9 3.2 3 1 0 3 3 2 0 AAA ATPase domain ATPase PF06745.13 KOG98132.1 - 0.067 12.5 3.2 3.4 6.9 0.0 3.5 4 0 0 4 4 4 0 KaiC Sigma54_activat PF00158.26 KOG98132.1 - 0.095 12.4 0.0 9.2 5.9 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 KOG98132.1 - 0.097 12.2 0.1 2.4 7.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.7 KOG98132.1 - 0.13 11.2 2.1 2.4 7.0 0.1 3.2 3 1 1 4 4 3 0 AAA-like domain AAA_21 PF13304.6 KOG98132.1 - 0.16 11.8 11.6 1 9.1 0.6 3.8 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 KOG98132.1 - 0.28 11.1 2.2 19 5.1 0.0 3.4 3 0 0 3 3 3 0 NACHT domain EMC3_TMCO1 PF01956.16 KOG98134.1 - 5.7e-50 169.4 3.3 7.8e-50 168.9 3.3 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Cro PF09048.10 KOG98134.1 - 0.16 12.0 0.0 2 8.5 0.0 2.2 2 0 0 2 2 2 0 Cro PAC2 PF09754.9 KOG98135.1 - 1.8e-18 67.3 0.0 2e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 PAC2 family FAT PF02259.23 KOG98137.1 - 4e-137 457.1 2.2 4e-137 457.1 2.2 2.2 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 KOG98137.1 - 1.4e-72 244.6 0.9 2.7e-72 243.6 0.0 2.0 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 KOG98137.1 - 6.8e-69 230.9 11.3 6e-63 211.5 0.1 5.8 4 2 1 5 5 5 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 KOG98137.1 - 1.7e-42 143.9 3.2 9.4e-42 141.5 0.5 3.1 2 0 0 2 2 2 1 FKBP12-rapamycin binding domain FATC PF02260.20 KOG98137.1 - 1.7e-18 66.1 0.3 4.4e-18 64.8 0.3 1.8 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 KOG98137.1 - 3.9e-13 49.6 1.1 0.079 13.4 0.0 8.6 7 1 2 9 9 9 3 HEAT repeats HEAT PF02985.22 KOG98137.1 - 6.4e-09 35.3 2.6 0.054 13.8 0.0 8.1 9 0 0 9 9 8 1 HEAT repeat HEAT_EZ PF13513.6 KOG98137.1 - 2.4e-07 31.1 2.7 1.9 9.1 0.0 9.3 9 2 2 11 11 10 1 HEAT-like repeat RTP1_C1 PF10363.9 KOG98137.1 - 0.0014 18.8 0.3 3 8.1 0.0 4.9 3 1 1 4 4 3 1 Required for nuclear transport of RNA pol II C-terminus 1 TPR_19 PF14559.6 KOG98137.1 - 0.0015 19.0 0.3 0.09 13.3 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat IFRD PF05004.13 KOG98137.1 - 0.0037 16.4 2.3 0.94 8.5 0.1 4.3 4 1 1 5 5 5 1 Interferon-related developmental regulator (IFRD) Vac14_Fab1_bd PF12755.7 KOG98137.1 - 0.0065 17.0 2.7 0.3 11.7 0.0 4.5 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region MOR2-PAG1_C PF14225.6 KOG98137.1 - 0.042 13.7 4.9 5 6.9 0.2 3.8 4 0 0 4 4 4 0 Cell morphogenesis C-terminal TPR_12 PF13424.6 KOG98137.1 - 0.059 13.7 1.0 13 6.1 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Sec7_N PF12783.7 KOG98137.1 - 1.1 9.2 13.6 0.19 11.6 2.9 5.1 5 0 0 5 5 5 0 Guanine nucleotide exchange factor in Golgi transport N-terminal LicD PF04991.13 KOG98138.1 - 3.9e-53 180.9 2.6 3.9e-53 180.9 2.6 6.2 4 2 1 5 5 5 1 LicD family Pkinase PF00069.25 KOG98139.1 - 1.4e-33 116.4 0.0 2.2e-33 115.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98139.1 - 1.5e-13 50.7 0.0 2e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG98139.1 - 5.7e-05 22.6 0.0 8.2e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOG98139.1 - 0.0022 17.4 0.0 0.0041 16.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AAA PF00004.29 KOG98140.1 - 7.5e-50 168.8 0.0 1e-42 145.7 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 KOG98140.1 - 3.4e-21 75.4 0.0 1.2e-20 73.7 0.0 2.0 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.6 KOG98140.1 - 4.3e-11 43.5 0.1 0.00062 20.2 0.0 3.7 3 1 1 4 4 3 2 AAA ATPase domain AAA_lid_3 PF17862.1 KOG98140.1 - 3.6e-10 39.5 0.0 1.3e-07 31.3 0.0 2.6 2 0 0 2 2 2 1 AAA+ lid domain AAA_14 PF13173.6 KOG98140.1 - 1.2e-07 31.9 0.0 0.0021 18.1 0.0 3.2 3 0 0 3 3 3 2 AAA domain NACHT PF05729.12 KOG98140.1 - 3.5e-07 30.3 1.2 0.0036 17.2 0.0 4.3 5 0 0 5 5 4 2 NACHT domain AAA_22 PF13401.6 KOG98140.1 - 2.2e-06 28.0 0.3 0.19 12.0 0.0 4.4 3 2 1 4 4 4 2 AAA domain RNA_helicase PF00910.22 KOG98140.1 - 3e-06 27.6 0.0 1.4 9.4 0.0 3.9 3 0 0 3 3 3 2 RNA helicase AAA_5 PF07728.14 KOG98140.1 - 2.7e-05 24.2 0.0 0.48 10.4 0.0 3.9 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) TsaE PF02367.17 KOG98140.1 - 5.8e-05 23.1 0.0 0.54 10.3 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 KOG98140.1 - 0.00035 20.8 0.0 0.037 14.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOG98140.1 - 0.00047 20.7 0.0 0.12 12.9 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 KOG98140.1 - 0.00048 20.3 0.0 0.011 15.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 KOG98140.1 - 0.00051 19.8 0.0 0.0066 16.2 0.0 2.6 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 KOG98140.1 - 0.00067 19.3 0.0 0.72 9.4 0.1 3.8 2 2 2 4 4 4 1 AAA domain ATPase_2 PF01637.18 KOG98140.1 - 0.0018 18.2 0.2 0.4 10.5 0.0 3.0 2 2 0 2 2 2 1 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 KOG98140.1 - 0.0039 17.0 0.0 0.45 10.2 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_7 PF12775.7 KOG98140.1 - 0.0077 15.8 0.0 2.1 7.9 0.1 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region Zeta_toxin PF06414.12 KOG98140.1 - 0.0098 15.2 0.0 2.9 7.1 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin ORF45 PF17620.2 KOG98140.1 - 0.013 15.6 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function AAA_24 PF13479.6 KOG98140.1 - 0.016 14.9 0.0 5.7 6.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain TIP49 PF06068.13 KOG98140.1 - 0.018 14.2 0.0 0.16 11.2 0.0 2.5 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_3 PF07726.11 KOG98140.1 - 0.024 14.5 0.0 0.37 10.6 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 KOG98140.1 - 0.026 15.0 0.2 0.43 11.0 0.0 2.7 2 1 0 2 2 2 0 AAA domain Vps4_C PF09336.10 KOG98140.1 - 0.026 14.5 0.1 0.16 12.0 0.1 2.4 2 1 0 2 2 1 0 Vps4 C terminal oligomerisation domain Sigma54_activat PF00158.26 KOG98140.1 - 0.028 14.1 0.0 11 5.7 0.0 2.7 2 1 0 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 KOG98140.1 - 0.035 13.8 0.0 1.3 8.7 0.0 2.7 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 KOG98140.1 - 0.044 13.0 0.0 4.3 6.4 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain DnaB_C PF03796.15 KOG98140.1 - 0.05 12.9 0.0 0.94 8.8 0.0 2.4 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Bac_DnaA PF00308.18 KOG98140.1 - 0.067 13.0 0.0 8.2 6.2 0.0 2.4 2 0 0 2 2 2 0 Bacterial dnaA protein Roc PF08477.13 KOG98140.1 - 0.09 13.0 0.1 0.87 9.8 0.0 2.7 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ATP-synt_ab PF00006.25 KOG98140.1 - 0.13 11.9 0.0 0.95 9.1 0.0 2.1 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain TniB PF05621.11 KOG98140.1 - 0.13 11.7 0.0 3.8 6.9 0.0 2.9 3 0 0 3 3 3 0 Bacterial TniB protein Mg_chelatase PF01078.21 KOG98140.1 - 0.18 11.2 0.1 0.78 9.1 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Synaptobrevin PF00957.21 KOG98141.1 - 3.1e-15 55.7 1.1 5.1e-15 55.0 1.1 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 KOG98141.1 - 2.4e-12 46.7 0.0 4.1e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain tRNA-synt_2b PF00587.25 KOG98142.1 - 3.1e-49 167.3 0.0 4.9e-49 166.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 KOG98142.1 - 9.8e-19 67.3 0.2 1.6e-18 66.7 0.2 1.3 1 0 0 1 1 1 1 Anticodon binding domain LRR_4 PF12799.7 KOG98143.1 - 1.2e-28 98.7 54.8 1.4e-09 38.1 3.9 7.4 4 2 2 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOG98143.1 - 7.6e-22 76.9 49.8 6.5e-09 35.4 5.7 6.7 2 1 5 7 7 7 7 Leucine rich repeat LRR_9 PF14580.6 KOG98143.1 - 3.3e-17 62.5 25.3 4.3e-10 39.4 5.4 4.8 1 1 3 5 5 5 4 Leucine-rich repeat LRR_6 PF13516.6 KOG98143.1 - 4.7e-07 29.3 19.9 0.071 13.2 0.2 7.0 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 KOG98143.1 - 9.2e-07 28.6 34.7 0.87 10.4 0.2 9.4 9 2 0 9 9 9 5 Leucine Rich Repeat LRR_5 PF13306.6 KOG98143.1 - 0.018 15.0 2.3 0.018 15.0 2.3 3.8 1 1 3 4 4 4 0 BspA type Leucine rich repeat region (6 copies) 2H-phosphodiest PF08975.10 KOG98143.1 - 0.096 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1868) PP-binding PF00550.25 KOG98144.1 - 2.4e-13 50.2 0.2 3.4e-13 49.7 0.2 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 KOG98144.1 - 2.6e-06 27.6 0.2 3.8e-06 27.0 0.2 1.3 1 0 0 1 1 1 1 Acyl-carrier DUF1493 PF07377.12 KOG98144.1 - 0.0058 17.1 0.4 0.0085 16.5 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1493) Diphthamide_syn PF01866.17 KOG98145.1 - 8.2e-68 229.1 0.0 1.3e-67 228.4 0.0 1.3 1 0 0 1 1 1 1 Putative diphthamide synthesis protein EF-hand_1 PF00036.32 KOG98146.1 - 1.5e-23 80.5 15.5 2.8e-05 23.3 1.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOG98146.1 - 2.7e-20 72.6 9.2 8.3e-12 45.4 2.4 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOG98146.1 - 5.9e-19 66.3 8.2 0.00024 20.8 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOG98146.1 - 5.2e-15 54.2 15.9 0.0014 18.0 0.2 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOG98146.1 - 2e-08 33.9 14.4 0.084 12.7 0.4 4.4 4 1 0 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.7 KOG98146.1 - 3.8e-06 26.8 10.0 0.024 14.6 0.2 4.0 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOG98146.1 - 2.5e-05 24.6 0.1 0.19 12.1 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KOG98146.1 - 0.00053 20.3 0.1 1.8 9.0 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain Mo25 PF08569.11 KOG98147.1 - 1.3e-112 376.4 8.8 1.5e-112 376.2 8.8 1.0 1 0 0 1 1 1 1 Mo25-like YqbF PF14553.6 KOG98147.1 - 0.12 12.2 0.0 0.78 9.7 0.1 2.3 2 0 0 2 2 2 0 YqbF, hypothetical protein domain ABC_membrane_2 PF06472.15 KOG98148.1 - 3.2e-74 249.7 9.2 4.6e-74 249.2 9.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 KOG98148.1 - 1.3e-16 61.4 0.0 3.8e-15 56.6 0.0 2.6 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 KOG98148.1 - 1.3e-05 25.2 0.5 0.0002 21.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KOG98148.1 - 0.005 17.4 0.2 0.005 17.4 0.2 3.1 3 1 0 3 3 3 1 AAA domain AAA_22 PF13401.6 KOG98148.1 - 0.025 14.8 0.0 0.093 13.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOG98148.1 - 0.028 14.2 0.0 0.075 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 KOG98148.1 - 0.17 11.2 0.0 0.37 10.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SUR7 PF06687.12 KOG98149.1 - 3.8e-09 36.5 24.3 1.1e-07 31.7 24.3 2.8 1 1 0 1 1 1 1 SUR7/PalI family Mtr2 PF10429.9 KOG98150.1 - 3.3e-82 274.3 0.1 3.9e-82 274.0 0.1 1.0 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 GATA PF00320.27 KOG98151.1 - 1.6e-10 40.4 7.8 3.9e-10 39.2 7.8 1.7 1 0 0 1 1 1 1 GATA zinc finger Orn_Arg_deC_N PF02784.16 KOG98152.1 - 2.9e-80 269.2 0.0 3.8e-80 268.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 KOG98152.1 - 1.2e-17 63.9 0.0 1.7e-17 63.4 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Voldacs PF03517.13 KOG98153.1 - 1.4e-25 90.0 0.0 2.1e-25 89.5 0.0 1.2 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling DUF1729 PF08354.10 KOG98154.1 - 6.2e-153 508.9 0.0 9e-153 508.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 KOG98154.1 - 2.4e-114 382.2 0.0 3.8e-113 378.2 0.0 3.0 4 0 0 4 4 4 1 Acyl transferase domain FAS_meander PF17951.1 KOG98154.1 - 1.4e-48 164.5 0.0 3.2e-48 163.3 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 KOG98154.1 - 4.1e-39 134.8 0.0 1.4e-38 133.0 0.0 1.9 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 KOG98154.1 - 2.6e-38 130.4 0.0 5.1e-38 129.4 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain FAS_N PF17828.1 KOG98154.1 - 2.7e-37 127.7 0.0 6e-37 126.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydrat_N PF13452.6 KOG98154.1 - 1.5e-15 57.5 0.0 4.2e-15 56.0 0.0 1.8 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase NMO PF03060.15 KOG98154.1 - 0.031 13.7 0.2 0.1 11.9 0.0 2.0 2 0 0 2 2 2 0 Nitronate monooxygenase Pribosyltran_N PF13793.6 KOG98155.1 - 3e-40 136.8 0.0 1.2e-39 134.9 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 KOG98155.1 - 4.5e-40 137.6 1.0 6.3e-32 111.1 0.1 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 KOG98155.1 - 8.8e-08 31.8 0.2 0.00015 21.3 0.1 2.2 2 0 0 2 2 2 2 Phosphoribosyl transferase domain Ribosomal_L22 PF00237.19 KOG98156.1 - 1.2e-37 128.3 2.0 2.1e-37 127.5 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e CASP_C PF08172.12 KOG98157.1 - 7.4e-69 231.9 2.2 7.4e-69 231.9 2.2 4.7 2 1 0 3 3 3 1 CASP C terminal FUSC PF04632.12 KOG98157.1 - 0.13 10.7 7.6 0.09 11.3 1.6 2.4 2 1 0 2 2 2 0 Fusaric acid resistance protein family Pox_A_type_inc PF04508.12 KOG98157.1 - 0.31 10.9 14.2 0.61 10.0 1.6 5.2 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat DUF5476 PF17570.2 KOG98157.1 - 1.9 8.9 4.6 1.5 9.2 0.2 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5476) DUF1515 PF07439.11 KOG98157.1 - 8.5 6.4 10.0 0.26 11.3 0.4 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1515) STE3 PF02076.15 KOG98158.1 - 2.2e-87 293.0 21.7 2.6e-87 292.7 21.7 1.0 1 0 0 1 1 1 1 Pheromone A receptor DUF2516 PF10724.9 KOG98158.1 - 0.45 10.8 5.8 2.4 8.5 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2516) Longin_2 PF18639.1 KOG98159.1 - 1.6e-64 216.8 3.1 2.8e-64 216.0 3.1 1.4 1 0 0 1 1 1 1 Yeast longin domain Zip PF02535.22 KOG98160.1 - 2.2e-24 86.3 18.7 2.3e-22 79.7 18.7 2.2 1 1 0 1 1 1 1 ZIP Zinc transporter MARVEL PF01284.23 KOG98160.1 - 0.011 15.8 2.4 0.29 11.2 0.1 2.8 2 1 0 3 3 3 0 Membrane-associating domain DUF3899 PF13038.6 KOG98160.1 - 0.094 13.2 1.1 0.51 10.9 0.0 2.8 4 0 0 4 4 4 0 Domain of unknown function (DUF3899) AA_permease PF00324.21 KOG98161.1 - 5.9e-102 341.7 43.5 7.3e-102 341.4 43.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG98161.1 - 2.6e-35 122.1 46.9 3.5e-35 121.7 46.9 1.0 1 0 0 1 1 1 1 Amino acid permease PgaD PF13994.6 KOG98161.1 - 0.63 10.1 0.0 0.63 10.1 0.0 3.3 2 1 1 3 3 3 0 PgaD-like protein GTP_EFTU PF00009.27 KOG98162.1 - 1.1e-36 126.2 0.0 2e-36 125.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 KOG98162.1 - 1.1e-14 54.2 0.0 3.2e-14 52.7 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOG98162.1 - 1.9e-14 53.8 0.0 4.8e-14 52.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFTUD2 PF16004.5 KOG98162.1 - 8e-12 45.8 8.1 9.8e-12 45.5 5.6 2.3 2 1 0 2 2 2 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 KOG98162.1 - 2e-10 40.5 0.0 3.9e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 KOG98162.1 - 0.0009 19.3 0.1 0.0027 17.8 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 KOG98162.1 - 0.0075 16.3 0.0 0.019 15.1 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II SRPRB PF09439.10 KOG98162.1 - 0.0083 15.6 0.1 0.24 10.8 0.1 2.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ebp2 PF05890.12 KOG98163.1 - 3.6e-85 285.8 27.1 3.6e-85 285.8 27.1 3.0 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 Pkinase PF00069.25 KOG98164.1 - 5.8e-36 124.2 0.6 4.4e-25 88.5 0.3 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98164.1 - 3.2e-20 72.5 0.0 3.9e-16 59.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOG98164.1 - 0.009 14.8 0.4 0.024 13.4 0.3 1.7 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOG98164.1 - 0.031 13.6 0.0 6.7 5.9 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 KOG98164.1 - 0.078 12.3 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L14 PF00238.19 KOG98165.1 - 3.8e-38 130.3 3.5 4.3e-38 130.1 3.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Pkinase PF00069.25 KOG98166.1 - 2.7e-41 141.7 0.2 1.2e-40 139.6 0.2 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98166.1 - 9.4e-19 67.7 0.0 1.7e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2623 PF11115.8 KOG98166.1 - 0.12 12.5 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2623) ORC6 PF05460.13 KOG98166.1 - 2.2 7.5 9.5 5 6.3 9.5 1.5 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) L51_S25_CI-B8 PF05047.16 KOG98167.1 - 4.4e-15 55.3 0.1 8.5e-15 54.4 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain HycA_repressor PF11046.8 KOG98167.1 - 0.059 13.6 0.0 0.077 13.2 0.0 1.2 1 0 0 1 1 1 0 Transcriptional repressor of hyc and hyp operons Pkinase PF00069.25 KOG98168.1 - 5.7e-74 248.8 0.0 7.3e-74 248.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98168.1 - 1.3e-40 139.3 0.0 1.8e-40 138.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG98168.1 - 0.00012 21.5 0.0 0.0003 20.2 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KOG98168.1 - 0.014 14.4 0.1 0.023 13.7 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 KOG98168.1 - 0.097 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 KOG98168.1 - 0.15 11.4 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOG98168.1 - 0.16 11.9 0.0 0.35 10.8 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family PigN PF04987.14 KOG98169.1 - 4.1e-131 438.0 49.9 5.7e-131 437.5 49.9 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 KOG98169.1 - 3.4e-10 40.1 2.9 4.4e-08 33.1 0.5 2.2 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KOG98169.1 - 3.4e-10 39.8 0.3 5.7e-10 39.1 0.3 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 KOG98169.1 - 0.00045 19.7 0.0 0.00072 19.0 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF1319 PF07028.11 KOG98169.1 - 0.068 13.4 0.1 0.18 12.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) DUF4083 PF13314.6 KOG98169.1 - 0.096 12.6 2.7 0.31 11.0 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) PIR PF00399.19 KOG98170.1 - 4.6e-63 207.6 115.3 3.3e-08 32.9 7.8 9.7 9 0 0 9 9 9 8 Yeast PIR protein repeat HTH_37 PF13744.6 KOG98170.1 - 0.0041 17.1 7.1 8 6.5 0.4 4.7 1 1 6 7 7 7 1 Helix-turn-helix domain Fimbrial_PilY2 PF14481.6 KOG98170.1 - 0.34 10.6 7.2 1.3 8.7 0.2 3.3 1 1 3 4 4 4 0 Type 4 fimbrial biogenesis protein PilY2 FANCI_S2 PF14676.6 KOG98170.1 - 7.9 6.8 5.8 3.2e+02 1.5 5.8 2.2 1 1 0 1 1 1 0 FANCI solenoid 2 PIR PF00399.19 KOG98171.1 - 8.8e-84 273.6 161.3 2.1e-08 33.5 9.1 12.7 12 0 0 12 12 12 12 Yeast PIR protein repeat Chitin_synth_1 PF01644.17 KOG98171.1 - 0.0072 16.3 14.6 2.1 8.3 0.5 4.1 1 1 3 4 4 4 4 Chitin synthase YdaS_antitoxin PF15943.5 KOG98171.1 - 0.021 14.7 8.4 3.3 7.6 0.2 4.4 1 1 3 5 5 5 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT vWA-TerF-like PF10138.9 KOG98171.1 - 1.2 9.2 7.3 10 6.1 0.5 2.7 1 1 1 2 2 2 0 vWA found in TerF C terminus GerPE PF10970.8 KOG98171.1 - 8.7 6.6 25.3 20 5.4 1.2 5.5 1 1 5 6 6 6 0 Spore germination protein GerPE PIR PF00399.19 KOG98172.1 - 1.7e-05 24.2 4.1 1.7e-05 24.2 4.1 2.9 3 0 0 3 3 3 1 Yeast PIR protein repeat SprB PF13573.6 KOG98172.1 - 0.0006 19.5 1.8 0.01 15.6 0.2 2.9 2 0 0 2 2 2 1 SprB repeat Methyltransf_28 PF02636.17 KOG98173.1 - 2.5e-20 73.2 0.0 3.2e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Tom37_C PF11801.8 KOG98173.1 - 0.073 13.0 0.1 0.27 11.2 0.1 1.9 2 0 0 2 2 2 0 Tom37 C-terminal domain Pkinase PF00069.25 KOG98174.1 - 7.8e-64 215.6 0.0 1e-63 215.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98174.1 - 6.4e-30 104.3 0.0 9.4e-30 103.7 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOG98174.1 - 2.4e-06 26.8 0.2 5.3e-06 25.6 0.2 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOG98174.1 - 0.0069 15.8 0.3 0.019 14.3 0.0 1.8 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family Elf1 PF05129.13 KOG98175.1 - 2.6e-31 107.5 2.8 3.4e-31 107.1 2.8 1.2 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Ribosomal_L37ae PF01780.19 KOG98175.1 - 0.12 12.4 1.5 0.21 11.7 1.5 1.3 1 0 0 1 1 1 0 Ribosomal L37ae protein family DNA_pol_phi PF04931.13 KOG98175.1 - 0.59 8.2 6.7 0.5 8.4 6.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi Calcipressin PF04847.12 KOG98176.1 - 7.7e-46 156.2 0.3 1.1e-45 155.7 0.3 1.2 1 0 0 1 1 1 1 Calcipressin Bunya_nucleocap PF00952.17 KOG98176.1 - 0.022 14.8 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Bunyavirus nucleocapsid (N) protein Ribosomal_S27e PF01667.17 KOG98177.1 - 3.1e-30 103.7 2.8 4e-30 103.3 2.8 1.2 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.21 KOG98177.1 - 0.005 17.0 0.9 0.0064 16.7 0.9 1.2 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain TF_Zn_Ribbon PF08271.12 KOG98177.1 - 0.023 14.2 4.2 0.035 13.6 4.2 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding zf-ACC PF17848.1 KOG98177.1 - 3.2 7.9 6.4 19 5.4 0.2 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Rsm22 PF09243.10 KOG98178.1 - 1.1e-29 103.5 0.4 9.5e-11 41.5 0.0 4.2 3 1 0 3 3 3 3 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 KOG98178.1 - 2.7e-06 27.3 0.0 7.2e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain VWA_N PF08399.11 KOG98178.1 - 0.04 14.4 2.9 0.14 12.7 0.1 2.5 2 0 0 2 2 2 0 VWA N-terminal Apis_Csd PF11671.8 KOG98178.1 - 0.75 9.8 4.2 0.2 11.7 0.7 1.8 2 0 0 2 2 2 0 Complementary sex determiner protein SRPRB PF09439.10 KOG98179.1 - 2e-67 226.1 0.6 2.8e-67 225.7 0.6 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 KOG98179.1 - 1.5e-10 40.8 0.0 2e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOG98179.1 - 2.5e-06 27.6 0.1 6.6e-06 26.2 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOG98179.1 - 0.00019 21.0 0.2 0.00039 20.0 0.2 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 KOG98179.1 - 0.0021 17.6 0.4 0.026 14.1 0.2 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FAM184 PF15665.5 KOG98179.1 - 0.015 15.1 0.3 0.021 14.6 0.3 1.1 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B ATP_bind_1 PF03029.17 KOG98179.1 - 0.03 14.1 0.1 0.087 12.6 0.0 1.6 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein DUF2570 PF10828.8 KOG98179.1 - 0.055 13.3 0.2 0.098 12.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) DUF1870 PF08965.10 KOG98179.1 - 0.075 13.1 0.2 0.075 13.1 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1870) AAA_22 PF13401.6 KOG98179.1 - 0.12 12.7 0.1 2.5 8.4 0.1 2.4 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 KOG98179.1 - 0.18 11.8 5.1 1.6 8.8 1.5 3.2 2 1 0 2 2 2 0 Dynamin family Vpu PF00558.19 KOG98179.1 - 0.78 9.6 4.6 0.33 10.7 0.9 2.1 2 0 0 2 2 2 0 Vpu protein His_Phos_1 PF00300.22 KOG98180.1 - 1e-37 129.7 0.1 6e-30 104.4 0.1 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Carb_kinase PF01256.17 KOG98181.1 - 2e-87 292.7 0.0 2.6e-87 292.4 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 KOG98181.1 - 9.7e-06 25.1 0.0 1.4e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase FAD_binding_6 PF00970.24 KOG98182.1 - 1e-28 99.6 0.0 1.6e-28 99.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KOG98182.1 - 2e-27 96.0 0.0 2.4e-26 92.5 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KOG98182.1 - 0.0007 19.7 0.0 0.048 13.8 0.0 2.8 2 1 1 3 3 3 1 Ferric reductase NAD binding domain DBR1 PF05011.13 KOG98183.1 - 1e-09 39.0 0.6 2.3e-09 37.8 0.1 1.8 1 1 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 KOG98183.1 - 2.2e-09 38.1 2.2 4e-09 37.3 2.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Usg PF06233.12 KOG98183.1 - 0.074 13.2 0.0 0.24 11.6 0.0 1.8 1 0 0 1 1 1 0 Usg-like family FAD_binding_2 PF00890.24 KOG98184.1 - 2.2e-123 412.4 2.1 2.9e-123 412.1 2.1 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 KOG98184.1 - 2.3e-44 150.5 0.9 3.7e-44 149.8 0.9 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 KOG98184.1 - 9.4e-07 28.2 0.5 0.00073 18.7 0.4 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 KOG98184.1 - 2.6e-05 23.6 1.1 6.8e-05 22.2 1.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOG98184.1 - 0.00032 20.0 0.2 0.01 15.1 0.1 2.4 2 0 0 2 2 2 1 Thi4 family BNIP2 PF12496.8 KOG98184.1 - 0.0036 17.7 1.1 0.0068 16.9 1.1 1.4 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 FAD_binding_3 PF01494.19 KOG98184.1 - 0.005 16.1 1.8 0.0081 15.4 0.2 2.2 3 0 0 3 3 3 1 FAD binding domain DAO PF01266.24 KOG98184.1 - 0.009 15.6 3.0 0.028 14.0 3.0 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOG98184.1 - 0.015 14.0 0.2 0.09 11.5 0.0 2.3 3 0 0 3 3 3 0 HI0933-like protein Pyr_redox_3 PF13738.6 KOG98184.1 - 0.91 8.7 3.4 6.3 6.0 1.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Aa_trans PF01490.18 KOG98185.1 - 7.4e-104 347.7 29.9 8.8e-104 347.4 29.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AAA PF00004.29 KOG98186.1 - 4.5e-40 137.1 0.0 8.1e-40 136.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG98186.1 - 1e-06 28.4 0.0 2.8e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 KOG98186.1 - 7.3e-05 22.8 0.0 0.00023 21.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOG98186.1 - 0.00011 22.5 0.0 0.0029 17.9 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 KOG98186.1 - 0.00024 21.6 0.0 0.0038 17.6 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 KOG98186.1 - 0.00026 21.2 0.0 0.00069 19.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 KOG98186.1 - 0.00097 18.4 0.0 0.0017 17.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 KOG98186.1 - 0.0034 17.2 0.0 0.0061 16.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 KOG98186.1 - 0.013 15.7 0.0 0.023 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KOG98186.1 - 0.026 14.9 0.0 0.073 13.5 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 KOG98186.1 - 0.027 14.2 0.0 0.079 12.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KOG98186.1 - 0.028 14.6 0.0 0.058 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Cwf_Cwc_15 PF04889.12 KOG98186.1 - 0.03 14.1 5.1 0.054 13.2 5.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein AAA_18 PF13238.6 KOG98186.1 - 0.031 14.8 0.4 0.081 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KOG98186.1 - 0.033 13.7 0.0 0.092 12.2 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 KOG98186.1 - 0.049 13.0 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KOG98186.1 - 0.051 13.4 0.0 0.091 12.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 KOG98186.1 - 0.054 12.7 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_14 PF13173.6 KOG98186.1 - 0.076 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 KOG98186.1 - 0.1 12.3 0.6 0.95 9.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 KOG98186.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_pol_Rbc25 PF08292.12 KOG98187.1 - 1.5e-51 174.0 0.1 2e-51 173.6 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 KOG98187.1 - 3.9e-20 72.0 0.0 5.7e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 LTV PF04180.14 KOG98188.1 - 2.8e-111 372.9 31.8 3.5e-111 372.7 31.8 1.0 1 0 0 1 1 1 1 Low temperature viability protein DUF3294 PF07957.11 KOG98189.1 - 2.5e-90 301.9 6.3 2.8e-90 301.8 6.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) Peptidase_M1 PF01433.20 KOG98189.1 - 0.031 13.8 0.5 3.7 7.0 0.1 2.1 2 0 0 2 2 2 0 Peptidase family M1 domain MCPVI PF02993.14 KOG98189.1 - 0.039 13.8 0.2 0.05 13.4 0.2 1.2 1 0 0 1 1 1 0 Minor capsid protein VI Tricorn_C1 PF14684.6 KOG98189.1 - 0.098 12.7 0.1 2.1 8.5 0.0 2.6 2 0 0 2 2 2 0 Tricorn protease C1 domain Pro-rich_19 PF15455.6 KOG98189.1 - 0.23 10.5 0.0 0.28 10.3 0.0 1.1 1 0 0 1 1 1 0 Proline-rich 19 ABC_tran_CTD PF16326.5 KOG98189.1 - 8.6 6.7 8.8 3.9 7.8 0.7 3.1 3 0 0 3 3 3 0 ABC transporter C-terminal domain Sdh_cyt PF01127.22 KOG98190.1 - 4.5e-22 78.3 3.6 6.6e-22 77.8 3.6 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Abhydrolase_1 PF00561.20 KOG98191.1 - 2.4e-40 138.8 0.1 3.6e-40 138.2 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 KOG98191.1 - 9.4e-22 76.4 0.1 1.7e-21 75.5 0.1 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 KOG98191.1 - 0.00013 21.4 0.0 0.0086 15.4 0.0 2.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.13 KOG98191.1 - 0.0003 20.5 0.0 0.23 11.1 0.0 2.4 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 KOG98191.1 - 0.003 17.4 0.0 0.88 9.3 0.0 2.3 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Ndr PF03096.14 KOG98191.1 - 0.1 11.3 0.1 0.33 9.6 0.0 1.8 2 0 0 2 2 2 0 Ndr family Pkinase PF00069.25 KOG98192.1 - 2.7e-77 259.7 0.1 4e-77 259.1 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98192.1 - 4.2e-33 114.7 0.0 6.1e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOG98192.1 - 9.1e-07 28.1 2.7 1.9e-06 27.1 2.2 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KOG98192.1 - 5e-05 22.8 0.0 0.00012 21.5 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOG98192.1 - 0.041 13.2 0.2 0.13 11.7 0.2 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1871 PF08958.10 KOG98192.1 - 0.062 13.6 0.4 0.24 11.8 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1871) Pkinase_fungal PF17667.1 KOG98192.1 - 1.5 7.5 10.2 5.4 5.7 10.2 2.0 1 1 0 1 1 1 0 Fungal protein kinase DASH_Hsk3 PF08227.11 KOG98193.1 - 3.2e-18 65.8 4.4 4.8e-18 65.2 4.4 1.3 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like DASH_Dad3 PF08656.10 KOG98193.1 - 0.031 14.3 2.2 0.042 13.9 2.2 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad3 DASH_Spc34 PF08657.10 KOG98193.1 - 0.062 13.1 0.7 0.061 13.1 0.7 1.0 1 0 0 1 1 1 0 DASH complex subunit Spc34 IFP_35_N PF07334.13 KOG98193.1 - 0.068 13.3 2.1 0.079 13.0 2.1 1.4 1 1 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus L31 PF09784.9 KOG98194.1 - 1.2e-40 138.0 5.3 3.4e-40 136.6 5.3 1.6 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L31 Cmc1 PF08583.10 KOG98195.1 - 5.3e-20 71.2 4.7 7e-20 70.8 4.7 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 KOG98195.1 - 0.0071 16.0 1.6 0.0098 15.6 1.6 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Acetyltransf_CG PF14542.6 KOG98195.1 - 0.018 15.2 0.1 0.03 14.4 0.1 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase COX17 PF05051.13 KOG98195.1 - 0.12 12.7 4.5 1.1 9.6 0.2 2.7 2 1 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 KOG98195.1 - 0.19 11.9 5.4 0.91 9.7 0.4 2.1 1 1 1 2 2 2 0 CHCH domain Adaptin_N PF01602.20 KOG98196.1 - 2.1e-133 445.7 22.4 2.6e-133 445.4 22.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KOG98196.1 - 1.2e-54 184.7 17.3 3.8e-53 179.9 7.9 3.1 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOG98196.1 - 6.9e-11 42.4 1.3 9e-05 22.8 0.2 5.2 3 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 KOG98196.1 - 7.2e-06 25.8 4.5 0.27 11.6 0.0 5.4 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 KOG98196.1 - 0.0065 17.0 0.3 13 6.5 0.0 4.6 4 0 0 4 4 4 1 HEAT-like repeat DUF5388 PF17363.2 KOG98196.1 - 0.012 15.8 0.2 0.069 13.4 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5388) Arm PF00514.23 KOG98196.1 - 0.36 11.0 6.2 0.36 10.9 0.5 3.8 4 1 1 5 5 5 0 Armadillo/beta-catenin-like repeat Peptidase_M3 PF01432.20 KOG98197.1 - 2.3e-152 508.5 0.0 2.9e-152 508.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 TPR_2 PF07719.17 KOG98198.1 - 0.00021 21.2 1.7 0.37 11.0 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOG98198.1 - 0.0082 15.9 2.5 1.4 8.9 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOG98198.1 - 0.032 14.4 4.5 0.43 10.9 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Luciferase_3H PF10284.9 KOG98198.1 - 0.08 13.1 0.1 0.19 11.9 0.1 1.6 1 0 0 1 1 1 0 Luciferase helical bundle domain TPR_12 PF13424.6 KOG98198.1 - 0.095 13.0 1.6 8.5 6.8 0.0 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat She2p PF11435.8 KOG98200.1 - 7.6e-89 296.7 4.0 9.3e-89 296.4 4.0 1.1 1 0 0 1 1 1 1 RNA binding protein She2p DUF5420 PF17457.2 KOG98200.1 - 0.028 14.3 0.1 0.051 13.4 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5420) Myosin_head PF00063.21 KOG98201.1 - 2.8e-229 762.8 6.6 3.7e-229 762.4 6.6 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 KOG98201.1 - 2.1e-45 154.7 0.3 4.8e-45 153.5 0.3 1.7 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 KOG98201.1 - 3.9e-11 42.4 0.0 7.5e-11 41.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOG98201.1 - 1.7e-07 31.0 0.0 3.8e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOG98201.1 - 0.0053 16.4 0.0 0.012 15.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain AAA_16 PF13191.6 KOG98201.1 - 0.036 14.5 0.0 0.098 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 KOG98201.1 - 0.049 13.9 0.0 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KOG98201.1 - 0.074 13.0 0.1 0.23 11.3 0.1 1.8 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 KOG98201.1 - 0.089 12.7 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Sigma54_activat PF00158.26 KOG98201.1 - 0.13 11.9 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Hpr_kinase_C PF07475.12 KOG98201.1 - 0.13 11.8 0.1 9.2 5.8 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain IQ PF00612.27 KOG98201.1 - 1 9.4 14.7 2.3 8.2 6.2 2.7 1 1 1 2 2 2 0 IQ calmodulin-binding motif Macoilin PF09726.9 KOG98201.1 - 2 6.9 9.2 3 6.3 9.2 1.3 1 0 0 1 1 1 0 Macoilin family His_Phos_1 PF00300.22 KOG98202.1 - 1.4e-07 31.4 0.3 0.00043 20.0 0.0 2.9 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) PGM_PMM_I PF02878.16 KOG98203.1 - 9.6e-35 119.3 0.2 1.9e-34 118.3 0.0 1.6 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 KOG98203.1 - 1.7e-25 89.5 0.0 3e-25 88.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 KOG98203.1 - 4e-11 43.5 0.0 8.4e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 KOG98203.1 - 2.9e-05 24.1 0.0 6.5e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Pkinase PF00069.25 KOG98204.1 - 2.9e-67 226.8 0.0 4.6e-67 226.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98204.1 - 6.1e-31 107.6 0.0 9.3e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 KOG98204.1 - 5.7e-12 46.2 0.3 1.5e-11 44.8 0.3 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 KOG98204.1 - 0.00035 19.6 0.0 0.00065 18.7 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain FOXO_KIX_bdg PF16675.5 KOG98204.1 - 0.0042 17.4 0.0 0.015 15.6 0.0 2.0 1 0 0 1 1 1 1 KIX-binding domain of forkhead box O, CR2 FTA2 PF13095.6 KOG98204.1 - 0.0075 15.9 0.1 3.3 7.3 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 KOG98204.1 - 0.011 15.1 0.0 0.033 13.5 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 KOG98204.1 - 0.095 12.0 0.3 0.2 11.0 0.3 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOG98204.1 - 0.22 11.4 0.0 0.36 10.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RRN3 PF05327.11 KOG98205.1 - 8.5e-184 612.2 10.2 1e-183 611.9 10.2 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 KOG98205.1 - 0.0004 18.8 1.4 0.00072 17.9 1.4 1.4 1 0 0 1 1 1 1 Nop14-like family MMTV_SAg PF01054.17 KOG98205.1 - 0.064 12.8 0.0 0.24 11.0 0.0 1.9 2 0 0 2 2 2 0 Mouse mammary tumour virus superantigen IFT57 PF10498.9 KOG98205.1 - 0.94 8.4 7.8 1.8 7.4 7.8 1.5 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 BUD22 PF09073.10 KOG98205.1 - 1.8 7.8 7.6 3 7.1 7.6 1.4 1 0 0 1 1 1 0 BUD22 SPRY PF00622.28 KOG98206.1 - 7.6e-12 45.4 0.0 1.7e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 SPRY domain SRP9-21 PF05486.12 KOG98207.1 - 3.7e-17 62.5 0.2 3.7e-17 62.5 0.2 3.7 2 2 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) DUF935 PF06074.12 KOG98207.1 - 0.012 14.4 1.5 0.015 14.1 1.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF935) DUF4758 PF15950.5 KOG98207.1 - 0.12 12.7 6.1 0.064 13.6 4.1 1.6 1 1 1 2 2 2 0 Putative sperm flagellar membrane protein DUF3525 PF12039.8 KOG98207.1 - 0.15 10.7 0.0 0.19 10.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) PPL5 PF18168.1 KOG98207.1 - 0.32 10.3 10.6 0.008 15.5 3.2 1.7 1 1 1 2 2 2 0 Prim-pol family 5 WD40 PF00400.32 KOG98208.1 - 5.6e-11 42.8 15.2 0.0027 18.5 0.1 6.6 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG98208.1 - 3.6e-05 24.0 0.0 0.41 11.0 0.0 4.4 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOG98208.1 - 0.024 13.6 0.0 0.3 10.0 0.0 2.8 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Baculo_VP91_N PF08475.10 KOG98208.1 - 0.52 10.0 4.7 3.7 7.2 0.3 2.8 2 1 1 3 3 3 0 Viral capsid protein 91 N-terminal Mito_carr PF00153.27 KOG98209.1 - 1.5e-54 181.9 7.3 1.1e-17 63.7 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 KOG98209.1 - 0.0089 16.2 0.1 0.71 10.1 0.1 2.7 3 0 0 3 3 3 1 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Vma12 PF11712.8 KOG98210.1 - 1.1e-35 122.7 1.6 1.5e-35 122.3 1.6 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase LapA_dom PF06305.11 KOG98210.1 - 0.14 12.0 0.9 0.36 10.7 0.3 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Pkinase PF00069.25 KOG98212.1 - 6.9e-43 146.9 0.0 1.2e-42 146.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98212.1 - 2e-27 96.1 0.0 5.4e-26 91.4 0.0 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOG98212.1 - 0.018 14.4 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Bunya_G1 PF03557.15 KOG98212.1 - 0.058 11.4 0.0 0.073 11.0 0.0 1.1 1 0 0 1 1 1 0 Bunyavirus glycoprotein G1 AP_endonuc_2 PF01261.24 KOG98213.1 - 6.4e-32 110.7 0.0 9e-32 110.2 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel XPG_N PF00752.17 KOG98214.1 - 1.5e-39 134.5 0.0 3.2e-39 133.5 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 KOG98214.1 - 1.8e-28 98.7 1.3 2.7e-28 98.1 0.0 2.0 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 KOG98214.1 - 3e-05 24.5 1.8 0.00011 22.8 0.0 2.6 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 KOG98214.1 - 0.0099 16.5 0.0 0.034 14.8 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain 5_3_exonuc_N PF02739.16 KOG98214.1 - 0.017 15.0 0.1 0.032 14.1 0.1 1.5 1 1 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain HHH_2 PF12826.7 KOG98214.1 - 0.018 15.1 0.1 0.062 13.4 0.0 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix motif CDKN3 PF05706.12 KOG98214.1 - 0.042 13.5 0.0 0.066 12.9 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) MRPL52 PF18699.1 KOG98214.1 - 0.068 13.4 0.9 0.068 13.4 0.9 2.4 2 0 0 2 2 2 0 Mitoribosomal protein mL52 BAF1_ABF1 PF04684.13 KOG98215.1 - 3.3e-185 617.4 100.7 4.3e-183 610.4 100.7 2.2 1 1 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor DBD_Tnp_Mut PF03108.15 KOG98215.1 - 0.0036 17.2 0.0 0.0094 15.9 0.0 1.7 1 0 0 1 1 1 1 MuDR family transposase KTI12 PF08433.10 KOG98216.1 - 5.8e-99 331.0 0.1 6.6e-99 330.8 0.1 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 KOG98216.1 - 2.1e-05 25.1 0.0 4.7e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOG98216.1 - 2.2e-05 24.6 0.0 5.1e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KOG98216.1 - 0.00041 20.8 0.0 0.0013 19.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 KOG98216.1 - 0.001 19.0 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_22 PF13401.6 KOG98216.1 - 0.0032 17.8 0.0 0.01 16.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KOG98216.1 - 0.0039 17.6 0.0 0.01 16.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 KOG98216.1 - 0.011 16.0 0.0 0.018 15.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 KOG98216.1 - 0.015 14.6 1.3 0.17 11.2 0.1 2.5 2 1 0 2 2 2 0 6-phosphofructo-2-kinase NACHT PF05729.12 KOG98216.1 - 0.021 14.7 0.0 0.043 13.7 0.0 1.7 1 1 0 1 1 1 0 NACHT domain TsaE PF02367.17 KOG98216.1 - 0.028 14.4 0.1 0.071 13.1 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 KOG98216.1 - 0.032 14.3 0.0 0.072 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOG98216.1 - 0.034 14.5 0.0 0.069 13.5 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 KOG98216.1 - 0.041 13.3 0.1 0.076 12.4 0.1 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit cobW PF02492.19 KOG98216.1 - 0.073 12.7 0.1 0.24 11.0 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 KOG98216.1 - 0.11 12.4 0.3 0.38 10.6 0.0 2.0 2 0 0 2 2 2 0 NTPase Mg_chelatase PF01078.21 KOG98216.1 - 0.15 11.5 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 KOG98216.1 - 0.16 11.9 1.1 0.95 9.3 0.5 2.4 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea Hap4_Hap_bind PF10297.9 KOG98217.1 - 7.2e-07 29.1 5.9 7.2e-07 29.1 5.9 2.0 2 0 0 2 2 2 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 Drc1-Sld2 PF11719.8 KOG98218.1 - 3.2e-43 148.9 29.7 1.1e-26 94.5 20.0 2.0 1 1 1 2 2 2 2 DNA replication and checkpoint protein adh_short PF00106.25 KOG98219.1 - 4.1e-09 36.2 0.1 8.9e-08 31.8 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOG98219.1 - 0.0004 20.0 0.0 0.01 15.4 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 KOG98219.1 - 0.0005 19.6 0.0 0.00073 19.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 KOG98219.1 - 0.0031 16.9 0.0 0.0049 16.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 KOG98219.1 - 0.0046 17.5 0.1 0.025 15.1 0.1 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_10 PF13460.6 KOG98219.1 - 0.01 15.8 0.1 0.017 15.0 0.1 1.3 1 0 0 1 1 1 0 NAD(P)H-binding KR PF08659.10 KOG98219.1 - 0.019 14.9 0.2 0.035 14.0 0.2 1.5 1 1 0 1 1 1 0 KR domain Sacchrp_dh_NADP PF03435.18 KOG98219.1 - 0.021 15.1 0.1 0.036 14.3 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 KOG98219.1 - 0.035 14.5 0.1 0.071 13.6 0.1 1.6 1 1 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 KOG98219.1 - 0.042 13.7 0.1 0.064 13.1 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 KOG98219.1 - 0.047 13.0 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NmrA PF05368.13 KOG98219.1 - 0.07 12.7 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 NmrA-like family Semialdhyde_dh PF01118.24 KOG98219.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Gp_dh_N PF00044.24 KOG98219.1 - 0.14 12.5 0.0 0.36 11.2 0.0 1.8 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain YjeF_N PF03853.15 KOG98219.1 - 0.16 11.9 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus Aminotran_1_2 PF00155.21 KOG98220.1 - 9.4e-99 331.0 0.0 1.1e-98 330.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II SIS PF01380.22 KOG98222.1 - 2.2e-65 218.4 0.1 1.3e-31 109.1 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 KOG98222.1 - 1.8e-16 60.5 0.0 4.1e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KOG98222.1 - 8.5e-10 38.6 0.0 1.7e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 KOG98222.1 - 2.4e-05 23.4 0.0 4.3e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Peptidase_M18 PF02127.15 KOG98223.1 - 1.2e-158 528.4 0.0 3.5e-158 526.9 0.0 1.6 1 1 1 2 2 2 1 Aminopeptidase I zinc metalloprotease (M18) YnfE PF17452.2 KOG98223.1 - 0.33 11.3 1.7 0.65 10.3 1.7 1.5 1 0 0 1 1 1 0 Uncharacterized YnfE-like Pkinase PF00069.25 KOG98224.1 - 2.8e-69 233.4 0.4 3.1e-63 213.6 0.0 2.6 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98224.1 - 7.1e-35 120.5 0.1 2e-33 115.8 0.0 2.4 1 1 1 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 KOG98224.1 - 0.0025 17.2 0.0 0.0046 16.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KOG98224.1 - 0.013 15.1 0.0 0.013 15.1 0.0 3.4 3 0 0 3 3 3 0 Choline/ethanolamine kinase APH PF01636.23 KOG98224.1 - 0.015 15.2 0.0 0.036 14.0 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_A22B PF04258.13 KOG98225.1 - 1.6e-103 346.1 14.5 2.8e-103 345.4 14.5 1.3 1 0 0 1 1 1 1 Signal peptide peptidase Utp11 PF03998.13 KOG98226.1 - 1.9e-66 224.5 35.4 2.2e-66 224.3 35.4 1.0 1 0 0 1 1 1 1 Utp11 protein Reo_P9 PF06043.11 KOG98226.1 - 0.016 14.6 0.5 0.031 13.7 0.5 1.4 1 0 0 1 1 1 0 Reovirus P9-like family DUF2529 PF10740.9 KOG98226.1 - 0.031 13.9 1.2 0.068 12.8 0.6 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF2529) SLATT_5 PF18160.1 KOG98226.1 - 1.5 8.1 6.1 0.24 10.7 0.4 2.1 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 PIR PF00399.19 KOG98229.1 - 1.3e-07 31.0 5.0 5.6e-07 28.9 5.0 2.2 1 0 0 1 1 1 1 Yeast PIR protein repeat Pex14_N PF04695.13 KOG98229.1 - 0.53 10.9 8.1 0.77 10.4 8.1 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF515 PF04415.12 KOG98229.1 - 2.9 6.2 26.1 3.9 5.7 26.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Apt1 PF10351.9 KOG98229.1 - 4.4 6.0 14.3 6 5.6 14.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF5521 PF17659.1 KOG98229.1 - 8.9 4.0 8.5 11 3.8 8.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5521) DUF572 PF04502.13 KOG98230.1 - 3.7e-49 168.1 12.2 4.4e-49 167.9 12.2 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Mut7-C PF01927.16 KOG98230.1 - 0.084 13.0 0.1 0.084 13.0 0.1 1.9 2 1 0 2 2 2 0 Mut7-C RNAse domain Cytochrom_C552 PF02335.15 KOG98230.1 - 0.15 10.9 0.1 0.15 10.9 0.1 2.1 2 0 0 2 2 2 0 Cytochrome c552 TadF PF16964.5 KOG98230.1 - 2.3 7.9 8.1 0.43 10.3 3.6 1.8 2 0 0 2 2 2 0 Putative tight adherence pilin protein F FUSC PF04632.12 KOG98230.1 - 4.8 5.6 3.9 6.4 5.2 3.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Iron_permease PF04120.12 KOG98230.1 - 7.8 6.3 8.5 2.4 7.9 4.7 1.9 1 1 1 2 2 2 0 Low affinity iron permease Hydrolase_4 PF12146.8 KOG98231.1 - 2.7e-49 167.6 0.0 4.2e-49 167.0 0.0 1.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOG98231.1 - 1.6e-27 96.8 0.0 1.9e-27 96.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOG98231.1 - 2.1e-09 38.3 0.0 2.6e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KOG98231.1 - 4.4e-05 23.0 0.4 0.00081 18.9 0.1 2.3 3 0 0 3 3 3 1 Prolyl oligopeptidase family DLH PF01738.18 KOG98231.1 - 5.4e-05 22.8 0.1 0.0099 15.5 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 KOG98231.1 - 0.0047 16.7 0.0 0.8 9.5 0.0 3.0 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Chlorophyllase2 PF12740.7 KOG98231.1 - 0.0051 15.8 0.0 0.0081 15.1 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme FSH1 PF03959.13 KOG98231.1 - 0.02 14.6 0.1 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Chlorophyllase PF07224.11 KOG98231.1 - 0.042 12.8 0.0 0.055 12.5 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Abhydrolase_3 PF07859.13 KOG98231.1 - 0.16 11.8 0.0 0.57 10.0 0.0 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold MBR1 PF17058.5 KOG98232.1 - 3.4e-50 171.2 10.2 3.4e-50 171.2 10.2 2.1 2 0 0 2 2 2 1 Mitochondrial biogenesis regulation protein 1 RasGAP PF00616.19 KOG98233.1 - 8.1e-39 133.5 7.3 8.1e-39 133.5 7.3 3.2 2 2 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 KOG98233.1 - 0.0014 18.9 0.1 0.0054 17.0 0.0 2.1 1 1 0 1 1 1 1 C2 domain CRAL_TRIO PF00650.20 KOG98234.1 - 6.3e-35 120.2 0.2 1.2e-34 119.4 0.2 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KOG98234.1 - 4.9e-10 39.4 1.9 5.1e-10 39.4 0.6 1.7 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 KOG98234.1 - 1.9e-06 28.0 0.1 3.3e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CUE PF02845.16 KOG98235.1 - 1.2e-19 69.6 4.1 1e-10 41.1 0.3 3.4 3 0 0 3 3 3 2 CUE domain Smr PF01713.21 KOG98235.1 - 0.0054 17.1 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 Smr domain DMA PF03474.14 KOG98235.1 - 0.16 11.6 0.1 2.1 8.0 0.0 2.4 2 0 0 2 2 2 0 DMRTA motif CENP-C_C PF11699.8 KOG98236.1 - 7.6e-31 106.2 1.8 1.9e-30 104.9 1.8 1.7 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.6 KOG98236.1 - 1.6e-05 25.6 4.6 1.6e-05 25.6 4.6 3.0 2 2 0 2 2 2 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.11 KOG98236.1 - 0.0079 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Cupin domain AT_hook PF02178.19 KOG98236.1 - 0.13 12.2 5.4 0.39 10.8 5.4 1.9 1 0 0 1 1 1 0 AT hook motif Flavoprotein PF02441.19 KOG98237.1 - 1.4e-48 164.6 0.1 2.3e-48 163.9 0.1 1.4 1 0 0 1 1 1 1 Flavoprotein EMC3_TMCO1 PF01956.16 KOG98237.1 - 5 6.8 5.6 10 5.8 5.6 1.6 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like LMBR1 PF04791.16 KOG98237.1 - 7.4 5.4 10.8 11 4.7 10.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Androgen_recep PF02166.16 KOG98237.1 - 8.6 5.1 7.7 13 4.5 7.7 1.2 1 0 0 1 1 1 0 Androgen receptor Cyto_heme_lyase PF01265.17 KOG98238.1 - 3.8e-37 128.5 10.5 1.2e-35 123.5 10.5 2.2 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase ParBc PF02195.18 KOG98239.1 - 4.2e-25 87.9 0.0 4.8e-25 87.7 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain Ldh_1_C PF02866.18 KOG98240.1 - 7.7e-57 191.9 0.3 1.9e-56 190.6 0.0 1.8 3 0 0 3 3 3 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KOG98240.1 - 1.2e-43 148.6 0.1 1.9e-43 147.9 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 KOG98240.1 - 0.0018 17.3 0.0 0.0026 16.8 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family zf-CHY PF05495.12 KOG98241.1 - 8.9e-13 48.5 13.4 1.3e-12 48.0 13.4 1.3 1 0 0 1 1 1 1 CHY zinc finger zf-RING_4 PF14570.6 KOG98241.1 - 0.00029 20.6 0.8 0.00029 20.6 0.8 2.9 2 1 1 3 3 3 1 RING/Ubox like zinc-binding domain A2L_zn_ribbon PF08792.10 KOG98241.1 - 0.00032 20.3 1.6 0.00032 20.3 1.6 2.0 2 1 0 2 2 2 1 A2L zinc ribbon domain PhnA_Zn_Ribbon PF08274.12 KOG98241.1 - 0.024 14.6 7.5 0.55 10.2 0.1 3.3 2 1 1 3 3 3 0 PhnA Zinc-Ribbon DZR PF12773.7 KOG98241.1 - 0.028 14.5 9.1 0.27 11.3 9.1 2.2 1 1 0 1 1 1 0 Double zinc ribbon LIM PF00412.22 KOG98241.1 - 0.029 14.6 13.2 0.88 9.8 2.7 2.7 1 1 1 2 2 2 0 LIM domain HypA PF01155.19 KOG98241.1 - 0.12 12.4 7.4 0.29 11.1 7.0 1.8 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_ribbon_recom PF13408.6 KOG98241.1 - 3.6 8.2 10.6 0.75 10.4 2.9 3.1 3 1 0 3 3 3 0 Recombinase zinc beta ribbon domain SURF6 PF04935.12 KOG98242.1 - 2e-47 161.6 54.1 2e-47 161.6 54.1 3.1 2 1 0 2 2 2 1 Surfeit locus protein 6 RRP14 PF15459.6 KOG98242.1 - 2.6e-12 47.2 1.8 2.6e-12 47.2 1.8 8.2 5 3 1 6 6 6 1 60S ribosome biogenesis protein Rrp14 V-ATPase_C PF03223.15 KOG98243.1 - 9.4e-119 397.1 0.4 1.1e-118 396.9 0.4 1.0 1 0 0 1 1 1 1 V-ATPase subunit C NUC130_3NT PF08158.12 KOG98243.1 - 0.004 17.5 0.1 6 7.3 0.0 2.7 2 0 0 2 2 2 2 NUC130/3NT domain APG6_N PF17675.1 KOG98243.1 - 1.6 9.3 4.0 23 5.5 0.3 2.6 3 0 0 3 3 3 0 Apg6 coiled-coil region Kinesin PF00225.23 KOG98244.1 - 1.1e-71 241.5 3.7 1.1e-71 241.5 3.7 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOG98244.1 - 2.8e-16 59.8 2.3 8.4e-16 58.2 0.1 2.6 2 0 0 2 2 2 1 Microtubule binding HA2 PF04408.23 KOG98245.1 - 1e-19 70.8 0.0 2.1e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KOG98245.1 - 4.6e-14 52.5 0.0 1.2e-13 51.3 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 KOG98245.1 - 2.7e-10 40.3 0.1 4.6e-10 39.5 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG98245.1 - 8.6e-09 35.7 0.0 2.5e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOG98245.1 - 5.9e-05 23.4 0.0 0.00012 22.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOG98245.1 - 0.00026 21.4 0.0 0.00045 20.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOG98245.1 - 0.0012 18.7 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 KOG98245.1 - 0.0028 18.2 0.1 0.1 13.1 0.1 2.8 2 1 1 3 3 3 1 ABC transporter AAA_14 PF13173.6 KOG98245.1 - 0.014 15.4 0.1 0.33 11.0 0.1 2.4 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOG98245.1 - 0.017 14.8 0.4 0.05 13.3 0.0 1.9 2 0 0 2 2 1 0 P-loop containing region of AAA domain Helicase_RecD PF05127.14 KOG98245.1 - 0.02 14.8 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 Helicase SRP54 PF00448.22 KOG98245.1 - 0.028 14.1 0.1 0.13 11.8 0.1 2.0 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.14 KOG98245.1 - 0.065 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_23 PF13476.6 KOG98245.1 - 0.068 13.7 0.6 0.17 12.3 0.2 1.9 1 1 0 1 1 1 0 AAA domain CRA PF06589.11 KOG98245.1 - 0.18 11.9 1.3 0.41 10.8 1.3 1.6 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) DUF4448 PF14610.6 KOG98246.1 - 2e-56 190.8 0.2 3.1e-56 190.2 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) FixQ PF05545.11 KOG98246.1 - 0.29 11.1 1.8 0.42 10.6 0.2 2.0 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ RRM_1 PF00076.22 KOG98248.1 - 0.0013 18.5 0.0 0.0053 16.5 0.0 2.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HSP70 PF00012.20 KOG98249.1 - 8.1e-50 169.6 0.1 8.1e-50 169.6 0.1 2.1 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 KOG98249.1 - 2.6e-05 23.2 0.0 0.00032 19.6 0.0 2.1 1 1 0 1 1 1 1 MreB/Mbl protein SCVP PF17619.2 KOG98250.1 - 0.47 11.3 9.8 44 5.0 0.6 4.1 4 0 0 4 4 4 0 Secreted clade V proteins DUF641 PF04859.12 KOG98250.1 - 1.7 9.0 6.5 4.8 7.5 3.7 2.7 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) zf-RRPl_C4 PF17026.5 KOG98250.1 - 3.8 7.6 9.4 1.5e+03 -0.7 9.1 2.9 1 1 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type GAF_2 PF13185.6 KOG98251.1 - 2.2e-08 34.5 0.0 3.2e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 KOG98251.1 - 1.9e-05 25.3 0.0 2.1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 GAF domain Nucleoporin_FG PF13634.6 KOG98253.1 - 7.1e-36 122.9 303.2 1.8e-09 38.3 27.1 11.0 1 1 12 13 13 13 10 Nucleoporin FG repeat region Nucleoporin2 PF04096.14 KOG98253.1 - 4.5e-35 120.9 0.0 8.4e-35 120.1 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin autopeptidase NDK PF00334.19 KOG98254.1 - 5.3e-55 185.1 0.0 6.1e-55 184.9 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Bap31 PF05529.12 KOG98256.1 - 5.1e-27 94.4 4.2 8.7e-27 93.6 4.2 1.3 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Rpp20 PF12328.8 KOG98256.1 - 0.02 14.9 2.9 0.031 14.3 2.9 1.3 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P Sec2p PF06428.11 KOG98256.1 - 0.026 14.5 5.0 0.047 13.7 5.0 1.4 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p p31comet PF06581.12 KOG98256.1 - 0.075 12.2 1.7 0.09 11.9 0.5 1.6 2 0 0 2 2 2 0 Mad1 and Cdc20-bound-Mad2 binding DUF2203 PF09969.9 KOG98256.1 - 0.17 12.6 0.9 1.6 9.5 1.5 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF4407 PF14362.6 KOG98256.1 - 0.73 9.1 4.0 0.13 11.6 0.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CorA PF01544.18 KOG98257.1 - 2.8e-38 131.9 3.3 3.7e-21 75.7 0.2 3.3 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein SID-1_RNA_chan PF13965.6 KOG98258.1 - 0.031 12.7 3.3 0.037 12.4 3.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SprA-related PF12118.8 KOG98258.1 - 0.11 11.6 22.3 0.15 11.2 22.3 1.1 1 0 0 1 1 1 0 SprA-related family Dsh_C PF12316.8 KOG98258.1 - 0.16 12.3 3.3 0.21 12.0 3.3 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal FHIPEP PF00771.20 KOG98258.1 - 0.18 10.2 3.7 0.21 10.0 3.7 1.1 1 0 0 1 1 1 0 FHIPEP family Neur_chan_memb PF02932.16 KOG98258.1 - 0.38 10.8 5.2 0.42 10.6 5.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 KOG98258.1 - 0.41 9.4 12.7 0.47 9.2 12.7 1.2 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 KOG98258.1 - 1.4 7.4 15.2 1.6 7.2 15.2 1.0 1 0 0 1 1 1 0 Macoilin family ALMT PF11744.8 KOG98258.1 - 2.7 6.7 9.4 3 6.6 9.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 KOG98258.1 - 6 5.8 18.2 6.5 5.7 18.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 FdhE PF04216.12 KOG98258.1 - 6.3 6.6 11.5 8.2 6.2 11.5 1.1 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation Membralin PF09746.9 KOG98258.1 - 7 5.6 7.1 7.7 5.4 7.1 1.2 1 0 0 1 1 1 0 Tumour-associated protein Spt20 PF12090.8 KOG98258.1 - 7 6.2 28.2 12 5.4 28.2 1.4 1 0 0 1 1 1 0 Spt20 family zf-C2H2 PF00096.26 KOG98259.1 - 9.2e-11 41.6 12.0 3.8e-06 27.1 2.7 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOG98259.1 - 3.7e-07 30.3 18.0 2.2e-06 27.8 2.3 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KOG98259.1 - 2.6e-06 27.6 12.1 0.017 15.4 0.7 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 KOG98259.1 - 4.7e-05 23.3 6.3 0.014 15.4 0.5 2.7 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_4 PF13894.6 KOG98259.1 - 0.00011 22.8 11.8 0.0018 18.9 2.0 3.0 3 0 0 3 3 2 2 C2H2-type zinc finger zf-met PF12874.7 KOG98259.1 - 0.005 17.2 6.1 1.4 9.4 2.0 3.2 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2HE PF16278.5 KOG98259.1 - 0.0066 16.9 10.4 0.027 14.9 1.1 3.1 2 1 1 3 3 3 1 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.7 KOG98259.1 - 0.079 13.3 8.0 0.94 9.8 1.9 3.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 KOG98259.1 - 0.092 12.6 2.3 9.4 6.1 0.1 3.0 2 1 1 3 3 3 0 GAGA factor zf-H2C2_5 PF13909.6 KOG98259.1 - 0.099 12.4 6.6 1 9.2 0.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-LYAR PF08790.11 KOG98259.1 - 0.18 11.7 3.6 6.8 6.7 0.2 2.6 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-Di19 PF05605.12 KOG98259.1 - 0.19 12.0 4.0 0.42 10.9 4.0 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 KOG98259.1 - 0.37 10.4 6.0 2.5 7.8 0.5 2.8 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_3rep PF18868.1 KOG98259.1 - 3.4 8.3 11.7 2.5 8.8 2.7 4.1 2 1 2 4 4 4 0 Zinc finger C2H2-type, 3 repeats Elf1 PF05129.13 KOG98259.1 - 5.3 7.2 8.3 1.7 8.7 1.0 2.6 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-C2H2_6 PF13912.6 KOG98259.1 - 6.4 6.9 12.6 3.7 7.7 4.7 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger BLI1 PF17324.2 KOG98260.1 - 1e-32 113.1 9.6 1.1e-32 113.0 9.6 1.0 1 0 0 1 1 1 1 BLOC-1 interactor 1 Streptin-Immun PF11083.8 KOG98260.1 - 0.014 15.8 1.6 0.014 15.8 1.6 1.5 2 0 0 2 2 2 0 Lantibiotic streptin immunity protein F_bP_aldolase PF01116.20 KOG98261.1 - 2.7e-86 289.6 0.0 3e-86 289.4 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II DWNN PF08783.11 KOG98262.1 - 6e-31 106.6 0.2 6e-31 106.6 0.2 2.1 2 0 0 2 2 2 1 DWNN domain zf-CCHC_2 PF13696.6 KOG98262.1 - 2.2e-06 27.4 7.0 2.2e-06 27.4 7.0 1.9 2 0 0 2 2 2 1 Zinc knuckle zf-Nse PF11789.8 KOG98262.1 - 0.00017 21.3 0.2 0.00041 20.1 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-CCHC PF00098.23 KOG98262.1 - 0.00085 19.3 3.3 0.0021 18.1 3.3 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 KOG98262.1 - 0.018 14.8 0.5 0.047 13.4 0.5 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Rubredoxin PF00301.20 KOG98262.1 - 0.025 14.6 3.7 0.99 9.5 0.0 3.0 3 0 0 3 3 3 0 Rubredoxin U-box PF04564.15 KOG98262.1 - 0.046 13.9 0.1 0.12 12.6 0.0 1.8 2 0 0 2 2 2 0 U-box domain zf-CCHC_3 PF13917.6 KOG98262.1 - 0.046 13.7 0.1 0.089 12.8 0.1 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-DNL PF05180.12 KOG98262.1 - 0.068 13.1 1.0 0.11 12.4 0.1 1.8 2 0 0 2 2 2 0 DNL zinc finger TF_Zn_Ribbon PF08271.12 KOG98262.1 - 1.2 8.7 4.4 0.69 9.5 0.2 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding TFIIA_gamma_C PF02751.14 KOG98263.1 - 1e-23 83.2 0.7 1.7e-23 82.5 0.7 1.4 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 KOG98263.1 - 1.5e-22 79.3 0.2 2e-22 78.9 0.2 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain Transketolase_C PF02780.20 KOG98263.1 - 0.046 13.6 0.0 0.059 13.2 0.0 1.2 1 0 0 1 1 1 0 Transketolase, C-terminal domain TCTP PF00838.17 KOG98265.1 - 2.4e-72 242.7 3.0 2.7e-72 242.5 3.0 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein adh_short PF00106.25 KOG98266.1 - 2.4e-33 115.2 0.8 2e-24 86.1 0.4 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOG98266.1 - 2.6e-21 76.2 1.2 3.2e-18 66.2 0.3 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 KOG98266.1 - 0.00065 19.2 0.1 0.44 10.0 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family KR PF08659.10 KOG98266.1 - 0.018 15.0 0.2 0.21 11.5 0.1 2.4 3 0 0 3 3 3 0 KR domain DUF1776 PF08643.10 KOG98266.1 - 0.033 13.5 0.4 0.044 13.1 0.4 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) CUE PF02845.16 KOG98267.1 - 1.3e-05 24.8 0.0 3.3e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 CUE domain UPF0203 PF05254.12 KOG98268.1 - 6.8e-28 96.7 2.3 7.9e-28 96.5 2.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) Cmc1 PF08583.10 KOG98268.1 - 0.0015 18.5 1.4 0.59 10.2 0.1 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like DUF3128 PF11326.8 KOG98268.1 - 0.021 15.1 1.6 0.31 11.4 1.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) UCR_hinge PF02320.16 KOG98268.1 - 0.035 14.3 2.6 0.1 12.8 2.6 1.7 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein PaREP1 PF05942.11 KOG98268.1 - 0.043 13.7 0.1 0.048 13.6 0.1 1.1 1 0 0 1 1 1 0 Archaeal PaREP1/PaREP8 family COX17 PF05051.13 KOG98268.1 - 0.044 14.2 1.2 0.41 11.0 1.2 2.3 2 1 1 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) CX9C PF16860.5 KOG98268.1 - 0.085 12.9 0.8 0.59 10.2 0.1 2.0 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 KOG98268.1 - 0.093 12.9 1.3 0.46 10.7 0.1 2.1 2 0 0 2 2 2 0 CHCH domain Pet191_N PF10203.9 KOG98268.1 - 0.24 11.7 2.0 7.8 6.9 0.2 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 DASH_Ask1 PF08655.10 KOG98269.1 - 1.5e-27 95.2 0.3 2.9e-27 94.3 0.3 1.5 1 0 0 1 1 1 1 DASH complex subunit Ask1 CPSF73-100_C PF11718.8 KOG98269.1 - 0.21 11.1 3.2 0.56 9.7 3.1 1.7 1 1 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term FRG2 PF15315.6 KOG98269.1 - 6.9 6.8 12.1 15 5.7 12.1 1.6 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 Frag1 PF10277.9 KOG98270.1 - 1.2e-88 296.3 23.0 1.4e-88 296.1 23.0 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Eisosome1 PF12757.7 KOG98271.1 - 4.2e-25 88.4 0.4 4.2e-25 88.4 0.4 3.4 3 1 1 4 4 4 1 Eisosome protein 1 HTH_Tnp_Tc3_2 PF01498.18 KOG98271.1 - 1 9.7 3.6 2.8 8.2 1.1 2.6 2 0 0 2 2 2 0 Transposase Pkinase PF00069.25 KOG98272.1 - 3e-40 138.3 0.0 5.9e-34 117.6 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98272.1 - 9.7e-19 67.6 0.0 2e-15 56.8 0.0 2.5 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOG98272.1 - 0.00043 19.7 0.0 0.0024 17.2 0.0 2.1 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOG98272.1 - 0.021 13.6 0.4 0.077 11.7 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase DUF2347 PF09804.9 KOG98273.1 - 7.2e-76 255.5 0.8 1.2e-75 254.7 0.8 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 KOG98273.1 - 2.2e-08 34.4 0.5 6.8e-06 26.3 0.0 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF4484) Avl9 PF09794.9 KOG98273.1 - 1.1e-07 30.9 0.1 0.00075 18.3 0.0 2.7 2 1 0 2 2 2 2 Transport protein Avl9 SPA PF08616.10 KOG98273.1 - 5.7e-07 29.5 0.0 1.3e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis DUF2895 PF11444.8 KOG98273.1 - 0.056 12.8 0.1 0.1 11.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) Glyco_hydro_76 PF03663.14 KOG98274.1 - 1.7e-161 537.8 26.2 2e-161 537.6 26.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 DNA_primase_lrg PF04104.14 KOG98275.1 - 2.3e-92 309.2 0.1 3.8e-92 308.4 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Cbl_N2 PF02761.14 KOG98275.1 - 0.057 14.1 0.3 6 7.6 0.0 3.3 3 0 0 3 3 3 0 CBL proto-oncogene N-terminus, EF hand-like domain KilA-N PF04383.13 KOG98276.1 - 1.4e-05 24.9 0.2 5.6e-05 23.0 0.2 2.1 1 1 0 1 1 1 1 KilA-N domain DUF3824 PF12868.7 KOG98276.1 - 2.6 8.7 13.7 1.7 9.3 10.3 2.0 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Spc42p PF11544.8 KOG98277.1 - 5.2e-23 80.8 13.6 5.2e-23 80.8 13.6 2.7 2 0 0 2 2 2 1 Spindle pole body component Spc42p DUF4116 PF13475.6 KOG98277.1 - 0.0049 16.6 0.7 0.015 15.0 0.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4116) PKcGMP_CC PF16808.5 KOG98277.1 - 0.98 9.3 15.2 2.7 7.9 3.5 4.1 3 1 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase UPF0242 PF06785.11 KOG98277.1 - 1.6 8.8 21.7 0.1 12.7 6.4 2.5 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Snf7 PF03357.21 KOG98278.1 - 1.1e-35 122.8 16.2 1.1e-35 122.8 16.2 1.5 2 0 0 2 2 2 1 Snf7 BAR PF03114.18 KOG98278.1 - 0.0068 16.1 0.9 0.0068 16.1 0.9 2.3 1 1 1 2 2 2 1 BAR domain PAS_7 PF12860.7 KOG98278.1 - 0.079 13.1 6.6 0.24 11.6 0.2 3.3 2 1 2 4 4 4 0 PAS fold Eno-Rase_FAD_bd PF07055.12 KOG98278.1 - 0.082 13.3 2.8 0.13 12.7 0.6 2.5 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain EMP70 PF02990.16 KOG98278.1 - 0.23 10.1 0.4 0.2 10.3 0.4 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 PSD4 PF07631.11 KOG98278.1 - 0.82 10.2 10.4 0.1 13.1 0.9 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1592) CheX PF13690.6 KOG98278.1 - 2.2 8.5 4.9 0.6 10.3 1.8 1.8 2 0 0 2 2 2 0 Chemotaxis phosphatase CheX Prominin PF05478.11 KOG98278.1 - 2.5 5.9 10.8 10 3.9 10.9 1.8 1 1 0 1 1 1 0 Prominin NifU PF01106.17 KOG98279.1 - 4.8e-26 90.7 0.0 7.8e-26 90.0 0.0 1.4 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 KOG98279.1 - 5.3e-24 84.1 0.2 1.3e-23 82.9 0.1 1.7 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal YojJ PF10372.9 KOG98279.1 - 0.0013 18.8 0.6 0.0026 17.8 0.6 1.5 1 0 0 1 1 1 1 Bacterial membrane-spanning protein N-terminus Lung_7-TM_R PF06814.13 KOG98280.1 - 8.1e-90 301.0 28.1 1e-89 300.7 28.1 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor Zn_clus PF00172.18 KOG98281.1 - 1.6e-09 37.7 12.7 2.8e-09 36.9 12.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rpp20 PF12328.8 KOG98281.1 - 0.33 10.9 0.0 0.33 10.9 0.0 2.7 3 0 0 3 3 3 0 Rpp20 subunit of nuclear RNase MRP and P UDPGP PF01704.18 KOG98282.1 - 4.8e-185 615.1 0.0 5.8e-185 614.8 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.6 KOG98282.1 - 0.0036 16.2 1.8 0.035 12.9 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4301) zf-rbx1 PF12678.7 KOG98283.1 - 1.6e-08 34.7 6.1 2.8e-08 33.9 6.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 KOG98283.1 - 4.1e-08 33.4 9.3 1.3e-07 31.8 9.3 1.9 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOG98283.1 - 5.8e-07 29.2 4.3 5.8e-07 29.2 4.3 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOG98283.1 - 4.6e-06 26.5 4.2 7.9e-06 25.7 4.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOG98283.1 - 2.9e-05 23.8 7.1 5.7e-05 22.9 7.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOG98283.1 - 5.1e-05 23.2 2.0 5.1e-05 23.2 2.0 1.9 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KOG98283.1 - 0.00043 20.1 5.2 0.00077 19.3 5.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KOG98283.1 - 0.00065 19.5 5.2 0.0017 18.2 5.2 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOG98283.1 - 0.001 18.8 9.0 0.0071 16.1 2.6 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 KOG98283.1 - 0.0012 18.8 2.2 0.0024 17.9 2.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KOG98283.1 - 0.0013 18.3 3.8 0.0013 18.3 3.8 1.6 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 KOG98283.1 - 0.05 13.8 5.0 0.16 12.1 5.0 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain CbiQ PF02361.16 KOG98283.1 - 0.46 10.1 5.8 0.26 10.9 2.6 2.1 2 0 0 2 2 2 0 Cobalt transport protein RINGv PF12906.7 KOG98283.1 - 2.9 8.1 7.3 0.34 11.1 2.8 1.8 2 0 0 2 2 2 0 RING-variant domain zf-P11 PF03854.14 KOG98283.1 - 3.3 7.4 6.6 1.1 8.9 3.4 1.8 2 0 0 2 2 2 0 P-11 zinc finger zf-C3H2C3 PF17122.5 KOG98283.1 - 5.5 7.1 6.2 1.4 9.0 2.4 2.0 2 0 0 2 2 2 0 Zinc-finger HAD_2 PF13419.6 KOG98284.1 - 7.2e-15 55.5 0.0 1.2e-14 54.8 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOG98284.1 - 5.2e-11 43.2 0.0 7.4e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 KOG98284.1 - 0.0089 16.1 0.0 0.032 14.3 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 KOG98284.1 - 0.1 13.0 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase HMG_box PF00505.19 KOG98286.1 - 5.1e-31 106.9 8.8 1.1e-17 64.2 2.3 3.9 4 0 0 4 4 4 2 HMG (high mobility group) box HMG_box_2 PF09011.10 KOG98286.1 - 5.2e-15 55.8 6.1 5.9e-10 39.6 2.2 4.4 5 1 1 6 6 6 2 HMG-box domain CHDNT PF08073.12 KOG98286.1 - 1.5e-09 37.6 0.0 0.00045 20.1 0.0 2.6 2 0 0 2 2 2 2 CHDNT (NUC034) domain Malic_M PF03949.15 KOG98287.1 - 2.5e-85 285.8 0.1 3.5e-85 285.4 0.1 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 KOG98287.1 - 4.8e-63 212.2 0.1 1.6e-62 210.5 0.0 1.8 2 0 0 2 2 2 1 Malic enzyme, N-terminal domain TFIIE_alpha PF02002.17 KOG98288.1 - 4.1e-37 126.2 0.1 4.1e-37 126.2 0.1 2.4 2 0 0 2 2 2 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.12 KOG98288.1 - 4.8e-09 35.6 0.8 4.8e-09 35.6 0.8 2.0 2 0 0 2 2 2 1 TFIIB zinc-binding zf-CCHC_2 PF13696.6 KOG98288.1 - 0.16 11.8 0.4 0.67 9.8 0.3 1.9 2 0 0 2 2 2 0 Zinc knuckle DUF1993 PF09351.10 KOG98288.1 - 2.9 8.0 8.5 16 5.6 4.6 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF1993) ThiF PF00899.21 KOG98289.1 - 6.1e-39 133.8 0.0 9e-39 133.3 0.0 1.1 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 KOG98289.1 - 0.00022 21.5 0.7 0.0055 17.0 0.7 2.5 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 KOG98289.1 - 0.00041 20.4 0.0 0.00079 19.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 KOG98289.1 - 0.0029 17.9 0.2 0.012 15.9 0.1 2.0 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_7 PF13241.6 KOG98289.1 - 0.01 16.2 0.1 0.03 14.7 0.0 2.0 2 1 0 2 2 2 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 KOG98289.1 - 0.022 14.3 0.1 0.066 12.8 0.1 1.8 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ATP19 PF11022.8 KOG98289.1 - 0.11 12.8 0.1 0.36 11.2 0.1 1.8 1 0 0 1 1 1 0 ATP synthase subunit K 3Beta_HSD PF01073.19 KOG98289.1 - 0.36 9.8 1.5 0.34 9.9 0.1 1.7 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Sir1 PF11603.8 KOG98290.1 - 1.5e-29 102.9 11.5 5.5e-16 59.1 0.1 3.9 3 1 0 3 3 3 2 Regulatory protein Sir1 DUF1835 PF08874.10 KOG98290.1 - 0.0037 17.5 0.0 0.0081 16.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1835) Pan3_PK PF18101.1 KOG98291.1 - 4.2e-52 175.8 0.3 7.9e-52 174.9 0.3 1.5 1 0 0 1 1 1 1 Pan3 Pseudokinase domain HIGH_NTase1 PF05636.11 KOG98291.1 - 0.053 12.7 0.2 0.09 12.0 0.2 1.3 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase ADK PF00406.22 KOG98292.1 - 1.7e-50 171.1 0.0 2.2e-50 170.7 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOG98292.1 - 2.6e-36 125.0 0.0 3.8e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOG98292.1 - 3.1e-09 37.4 0.0 4.6e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 KOG98292.1 - 5.8e-07 29.4 0.1 0.029 14.1 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase AAA_33 PF13671.6 KOG98292.1 - 2e-05 24.8 0.0 5.2e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KOG98292.1 - 0.015 14.6 0.0 0.028 13.7 0.0 1.6 1 1 0 1 1 1 0 Zeta toxin SRP54 PF00448.22 KOG98292.1 - 0.18 11.4 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DUF4648 PF15505.6 KOG98293.1 - 0.0052 17.6 0.1 0.0099 16.7 0.1 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4648) Macoilin PF09726.9 KOG98294.1 - 0.07 11.7 27.6 0.099 11.2 27.6 1.1 1 0 0 1 1 1 0 Macoilin family CCSAP PF15748.5 KOG98294.1 - 4.9 7.3 33.7 0.091 12.9 11.1 2.1 1 1 1 2 2 2 0 Centriole, cilia and spindle-associated TPR_1 PF00515.28 KOG98295.1 - 1.8e-38 128.8 18.8 1.7e-06 27.6 0.2 10.5 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOG98295.1 - 6.7e-36 119.5 9.8 3.1e-05 23.8 0.0 10.5 10 0 0 10 10 10 6 Tetratricopeptide repeat ANAPC3 PF12895.7 KOG98295.1 - 2.9e-26 91.5 20.6 1.5e-22 79.6 0.1 6.0 4 2 3 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 KOG98295.1 - 8e-24 81.8 14.4 0.00043 20.3 0.0 9.4 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 KOG98295.1 - 3.4e-18 65.7 2.1 1.3e-07 31.8 0.0 7.7 6 3 0 7 7 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOG98295.1 - 3.7e-18 64.9 9.5 4e-05 23.2 0.0 8.5 6 2 2 8 8 8 5 TPR repeat TPR_19 PF14559.6 KOG98295.1 - 1.6e-17 63.8 0.1 0.081 13.4 0.0 6.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOG98295.1 - 3.3e-15 55.3 8.4 0.025 14.9 0.0 8.4 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOG98295.1 - 8e-14 50.6 2.3 0.05 13.6 0.0 8.0 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOG98295.1 - 4.3e-12 46.5 0.0 0.11 13.2 0.0 5.9 7 0 0 7 7 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOG98295.1 - 6.8e-09 35.8 0.0 3.7 8.6 0.2 8.0 6 2 4 10 10 9 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOG98295.1 - 1.5e-08 34.2 3.7 0.96 9.4 0.0 7.3 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOG98295.1 - 6.3e-08 32.8 11.1 1.1 10.0 0.0 8.4 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOG98295.1 - 2.6e-05 23.6 0.0 0.4 9.8 0.0 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KOG98295.1 - 0.00075 19.0 0.0 0.22 10.8 0.0 3.2 3 0 0 3 3 3 1 MalT-like TPR region SRP_TPR_like PF17004.5 KOG98295.1 - 0.0049 16.9 9.6 0.89 9.6 0.0 5.4 4 2 1 5 5 5 1 Putative TPR-like repeat SPO22 PF08631.10 KOG98295.1 - 0.0074 15.8 3.8 0.016 14.7 2.0 2.5 2 0 0 2 2 2 1 Meiosis protein SPO22/ZIP4 like TPR_21 PF09976.9 KOG98295.1 - 0.094 12.4 0.0 1.6 8.4 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain Fis1_TPR_C PF14853.6 KOG98295.1 - 0.26 11.4 7.6 12 6.1 0.0 4.7 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Clathrin PF00637.20 KOG98295.1 - 5.8 6.8 14.9 0.09 12.6 1.3 4.1 4 1 1 5 5 5 0 Region in Clathrin and VPS WD40 PF00400.32 KOG98296.1 - 4e-22 78.1 9.3 3.8e-05 24.4 1.1 6.0 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG98296.1 - 9.5e-07 29.0 0.7 1.6 9.1 0.0 4.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOG98296.1 - 2.5e-05 23.1 2.4 0.083 11.5 0.2 3.0 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 KOG98296.1 - 0.00074 18.4 3.2 0.27 9.9 0.7 3.4 2 1 2 4 4 4 2 Nup133 N terminal like MRP-S32 PF10210.9 KOG98296.1 - 0.012 16.1 0.1 0.027 15.0 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 DUF4829 PF16111.5 KOG98296.1 - 0.47 11.3 4.4 0.32 11.8 2.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4829) Ank_4 PF13637.6 KOG98297.1 - 1.4e-12 47.8 2.8 1.9e-10 41.1 0.3 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOG98297.1 - 3.7e-12 46.6 0.1 9.4e-12 45.4 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOG98297.1 - 1.3e-11 44.4 0.4 2.6e-05 24.5 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOG98297.1 - 9.8e-11 40.9 1.9 3.7e-05 23.8 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KOG98297.1 - 8.7e-10 38.7 0.6 1.3e-07 31.7 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) TIG PF01833.24 KOG98297.1 - 1.6e-06 28.1 0.7 1e-05 25.5 0.7 2.5 2 0 0 2 2 2 1 IPT/TIG domain RHD_dimer PF16179.5 KOG98297.1 - 0.027 14.5 0.0 0.07 13.2 0.0 1.7 1 0 0 1 1 1 0 Rel homology dimerisation domain PPTA PF01239.22 KOG98298.1 - 1.9e-37 125.9 13.6 1.4e-07 31.0 0.6 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat PPV_E2_N PF00508.17 KOG98298.1 - 0.1 11.9 1.5 0.15 11.4 0.7 1.6 2 0 0 2 2 2 0 E2 (early) protein, N terminal DUF1748 PF08520.10 KOG98299.1 - 3.5e-12 46.0 0.2 4.6e-12 45.7 0.2 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) IFR3_antag PF14754.6 KOG98299.1 - 0.11 11.7 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Papain-like auto-proteinase WD40 PF00400.32 KOG98300.1 - 4.2e-15 55.9 0.1 0.00019 22.1 0.0 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG98300.1 - 5.4e-09 36.2 0.0 0.0011 19.3 0.0 3.8 2 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOG98300.1 - 0.00045 20.2 0.1 0.043 13.7 0.0 3.2 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A AAA_12 PF13087.6 KOG98301.1 - 5.3e-58 195.9 0.0 5.3e-58 195.9 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.6 KOG98301.1 - 8.2e-55 186.4 3.8 3.5e-54 184.3 0.2 2.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOG98301.1 - 3.5e-12 46.9 0.0 2.6e-11 44.0 0.0 2.5 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 KOG98301.1 - 1.5e-10 41.2 1.8 0.01 15.6 0.0 3.6 4 0 0 4 4 4 3 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 KOG98301.1 - 4.2e-10 39.7 0.0 4.4e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 KOG98301.1 - 2.5e-06 27.6 3.3 3.2e-06 27.3 0.3 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOG98301.1 - 3.2e-05 24.2 0.2 0.00059 20.1 0.1 3.0 3 1 0 3 3 3 1 AAA domain PhoH PF02562.16 KOG98301.1 - 4.5e-05 23.0 0.0 0.0006 19.3 0.0 2.6 2 0 0 2 2 2 1 PhoH-like protein DEAD PF00270.29 KOG98301.1 - 4.9e-05 23.2 0.3 0.0013 18.6 0.0 2.4 1 1 1 2 2 2 1 DEAD/DEAH box helicase DUF2075 PF09848.9 KOG98301.1 - 0.00027 20.3 1.5 0.011 15.1 1.5 2.7 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.21 KOG98301.1 - 0.00055 19.5 8.1 0.001 18.7 1.4 3.2 2 1 1 3 3 3 1 UvrD/REP helicase N-terminal domain Adeno_IVa2 PF02456.15 KOG98301.1 - 0.0018 17.2 0.2 0.0038 16.1 0.2 1.6 1 1 0 1 1 1 1 Adenovirus IVa2 protein Helicase_RecD PF05127.14 KOG98301.1 - 0.0046 16.8 0.0 0.033 14.1 0.0 2.6 2 1 0 2 2 2 1 Helicase Zot PF05707.12 KOG98301.1 - 0.0083 15.8 0.0 0.7 9.5 0.0 3.1 2 1 1 3 3 3 1 Zonular occludens toxin (Zot) AAA PF00004.29 KOG98301.1 - 0.0095 16.4 0.0 0.032 14.7 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 KOG98301.1 - 0.0096 16.4 0.1 0.0096 16.4 0.1 3.6 3 1 0 4 4 3 1 AAA domain AAA_14 PF13173.6 KOG98301.1 - 0.013 15.6 0.5 0.53 10.3 0.3 3.0 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.6 KOG98301.1 - 0.018 15.2 0.1 0.11 12.7 0.0 2.3 2 1 0 2 2 2 0 AAA domain UvrD_C_2 PF13538.6 KOG98301.1 - 0.02 14.7 0.0 0.041 13.7 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_25 PF13481.6 KOG98301.1 - 0.043 13.4 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOG98301.1 - 0.045 14.1 0.0 0.093 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain HeLo PF14479.6 KOG98301.1 - 0.047 13.5 1.4 0.12 12.2 0.6 2.0 2 0 0 2 2 2 0 Prion-inhibition and propagation RNA_helicase PF00910.22 KOG98301.1 - 0.091 13.2 0.0 0.34 11.3 0.0 2.1 1 0 0 1 1 1 0 RNA helicase Ubiquitin_4 PF18036.1 KOG98301.1 - 0.094 12.8 3.8 5 7.3 1.3 3.1 3 0 0 3 3 3 0 Ubiquitin-like domain AAA_24 PF13479.6 KOG98301.1 - 2.9 7.6 7.3 3.2 7.4 2.0 3.1 2 1 0 2 2 2 0 AAA domain Mt_ATP-synt_D PF05873.12 KOG98302.1 - 3.7e-18 65.8 5.4 5e-18 65.4 5.4 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) T5orf172 PF10544.9 KOG98302.1 - 0.045 14.3 0.3 0.069 13.7 0.3 1.5 1 1 0 1 1 1 0 T5orf172 domain DUF16 PF01519.16 KOG98302.1 - 0.12 12.8 5.3 0.22 12.0 4.2 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF16 Fungal_trans PF04082.18 KOG98303.1 - 7.2e-19 67.9 2.6 7.2e-19 67.9 2.6 2.3 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG98303.1 - 4.6e-10 39.4 7.2 8.2e-10 38.6 7.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PI3K_1B_p101 PF10486.9 KOG98303.1 - 5.2 4.7 9.8 7.2 4.3 4.5 2.2 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Npa1 PF11707.8 KOG98304.1 - 8.1e-93 311.5 6.0 8.1e-93 311.5 6.0 2.5 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 KOG98304.1 - 6e-46 156.6 0.0 6e-46 156.6 0.0 4.8 6 1 1 7 7 7 1 Nucleolar pre-ribosomal-associated protein 1 DUF2184 PF09950.9 KOG98304.1 - 0.047 13.1 0.2 0.1 12.0 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2184) Thg1 PF04446.12 KOG98304.1 - 0.26 11.3 3.6 0.24 11.5 0.2 2.7 4 0 0 4 4 4 0 tRNAHis guanylyltransferase ARPC4 PF05856.12 KOG98305.1 - 1e-72 243.2 3.5 1.1e-72 243.0 3.5 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) FF PF01846.19 KOG98306.1 - 6.9e-39 131.8 35.0 3.1e-13 49.7 1.4 7.0 9 0 0 9 9 9 4 FF domain WW PF00397.26 KOG98306.1 - 5.3e-23 80.8 9.4 1.7e-12 47.2 0.9 3.1 2 0 0 2 2 2 2 WW domain Glyco_hyd_101C PF17451.2 KOG98306.1 - 0.1 12.9 12.2 0.36 11.1 0.9 3.5 2 1 2 4 4 4 0 Glycosyl hydrolase 101 beta sandwich domain Ydc2-catalyt PF09159.10 KOG98307.1 - 2.8e-52 178.2 2.2 4.8e-52 177.4 2.2 1.4 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pox_A22 PF04848.13 KOG98307.1 - 0.0011 19.0 0.0 1.5 8.9 0.0 2.8 2 1 0 2 2 2 2 Poxvirus A22 protein HECT PF00632.25 KOG98308.1 - 1.7e-72 244.5 0.5 2.9e-72 243.7 0.5 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) EIAV_GP90 PF00971.18 KOG98308.1 - 0.039 12.6 0.2 2.8 6.5 0.1 2.2 2 0 0 2 2 2 0 EIAV coat protein, gp90 Ribosomal_L10 PF00466.20 KOG98309.1 - 1.2e-19 70.2 0.0 1.8e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 KOG98309.1 - 6.8e-17 61.2 0.0 1.1e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P TRAM_LAG1_CLN8 PF03798.16 KOG98310.1 - 4.8e-37 127.6 25.3 4.8e-37 127.6 25.3 2.2 2 1 0 2 2 2 1 TLC domain TRAM1 PF08390.11 KOG98310.1 - 6.2e-22 77.0 2.4 6.2e-22 77.0 2.4 1.9 2 0 0 2 2 2 1 TRAM1-like protein F-actin_cap_A PF01267.17 KOG98311.1 - 6.1e-79 265.2 0.1 6.9e-79 265.0 0.1 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit CdiI_2 PF18593.1 KOG98311.1 - 0.067 13.8 0.2 0.37 11.5 0.0 2.2 3 0 0 3 3 3 0 CdiI immunity protein Ribosomal_L14e PF01929.17 KOG98313.1 - 4.8e-33 113.5 0.6 9.2e-33 112.6 0.6 1.5 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 KOG98313.1 - 0.00062 19.6 0.4 0.0015 18.4 0.4 1.7 1 0 0 1 1 1 1 KOW motif TFIIS_M PF07500.14 KOG98314.1 - 2.3e-21 76.3 1.3 7.1e-21 74.8 1.3 1.9 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.13 KOG98314.1 - 3.3e-12 46.6 0.0 7.6e-12 45.4 0.0 1.7 1 1 0 1 1 1 1 SPOC domain PHD PF00628.29 KOG98314.1 - 1.7e-09 37.4 6.8 3.3e-09 36.5 6.8 1.5 1 0 0 1 1 1 1 PHD-finger PHD_Oberon PF07227.11 KOG98314.1 - 0.024 14.5 2.0 0.043 13.7 2.0 1.3 1 0 0 1 1 1 0 PHD - plant homeodomain finger protein zf-CW PF07496.15 KOG98314.1 - 0.039 14.0 0.6 0.089 12.8 0.6 1.6 1 0 0 1 1 1 0 CW-type Zinc Finger PHD_4 PF16866.5 KOG98314.1 - 1.8 8.7 4.9 5.2 7.2 4.9 1.8 1 0 0 1 1 1 0 PHD-finger PAP2_3 PF14378.6 KOG98315.1 - 2.7e-23 82.6 10.8 2.7e-23 82.6 10.8 2.1 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 KOG98315.1 - 1.3e-09 37.9 8.1 1.3e-09 37.9 8.1 2.4 2 2 1 3 3 3 1 PAP2 superfamily Ribosomal_S6 PF01250.17 KOG98316.1 - 2.3e-24 85.5 0.1 3.3e-24 85.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S6 Snf7 PF03357.21 KOG98317.1 - 1.9e-17 63.4 9.8 1.8e-16 60.2 10.6 1.8 2 0 0 2 2 2 1 Snf7 DUF1002 PF06207.11 KOG98317.1 - 0.022 14.3 0.5 0.029 13.9 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) APS_kinase PF01583.20 KOG98318.1 - 1.6e-74 249.1 0.0 1.9e-74 248.8 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 KOG98318.1 - 2.6e-06 27.7 0.0 7.4e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 KOG98318.1 - 0.00019 21.0 0.0 0.00021 20.8 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 KOG98318.1 - 0.00049 20.7 0.0 0.00081 19.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 KOG98318.1 - 0.00067 19.4 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 P-loop containing region of AAA domain CPT PF07931.12 KOG98318.1 - 0.0094 15.8 0.5 0.34 10.7 0.5 2.4 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.6 KOG98318.1 - 0.034 14.5 0.0 0.037 14.4 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain CbiA PF01656.23 KOG98318.1 - 0.048 13.7 0.0 0.067 13.2 0.0 1.2 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Zeta_toxin PF06414.12 KOG98318.1 - 0.058 12.7 0.0 0.1 11.8 0.0 1.5 1 1 1 2 2 2 0 Zeta toxin ABC_tran PF00005.27 KOG98318.1 - 0.07 13.6 0.0 0.089 13.3 0.0 1.2 1 0 0 1 1 1 0 ABC transporter G-alpha PF00503.20 KOG98318.1 - 0.077 12.1 0.1 0.2 10.8 0.0 1.4 1 1 0 1 1 1 0 G-protein alpha subunit PRK PF00485.18 KOG98318.1 - 0.096 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Dynamin_M PF01031.20 KOG98319.1 - 1.3e-101 339.6 0.7 2.5e-101 338.7 0.1 1.8 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 KOG98319.1 - 1e-57 194.9 1.1 1.7e-57 194.1 0.1 1.9 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 KOG98319.1 - 6.7e-28 96.7 5.5 1.7e-27 95.4 5.5 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 KOG98319.1 - 0.00045 20.3 0.8 0.0022 18.0 0.8 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 KOG98319.1 - 0.083 13.4 0.3 0.72 10.4 0.1 2.4 2 1 1 3 3 3 0 ABC transporter PAP_central PF04928.17 KOG98320.1 - 1.3e-109 365.0 0.0 3.6e-109 363.5 0.0 1.6 2 0 0 2 2 2 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 KOG98320.1 - 4.9e-51 172.8 0.1 9e-51 171.9 0.1 1.4 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 KOG98320.1 - 5.1e-14 52.3 0.4 1.4e-13 50.9 0.0 1.9 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 KOG98320.1 - 0.04 14.0 0.2 0.21 11.7 0.0 2.2 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase Oxysterol_BP PF01237.18 KOG98321.1 - 7e-87 291.7 0.4 6.5e-85 285.2 0.4 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein Adenosine_kin PF04008.14 KOG98323.1 - 0.089 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Adenosine specific kinase SDA1 PF05285.12 KOG98323.1 - 0.48 9.8 13.9 3.5 7.0 11.2 2.2 2 0 0 2 2 2 0 SDA1 Ribosomal_L50 PF10501.9 KOG98324.1 - 7.6e-19 67.9 0.6 1.7e-18 66.7 0.6 1.6 1 0 0 1 1 1 1 Ribosomal subunit 39S DUF3520 PF12034.8 KOG98324.1 - 0.078 13.1 0.5 0.13 12.4 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3520) LAMTOR PF15454.6 KOG98325.1 - 5.2e-21 75.0 4.2 5.2e-21 75.0 4.2 2.0 2 1 0 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Sigma70_ner PF04546.13 KOG98325.1 - 0.11 12.4 5.6 0.13 12.1 5.3 1.4 1 1 0 1 1 1 0 Sigma-70, non-essential region FAM176 PF14851.6 KOG98325.1 - 0.38 10.4 8.5 0.055 13.1 1.1 2.2 1 1 1 2 2 2 0 FAM176 family DUF5302 PF17227.2 KOG98325.1 - 1.5 9.9 6.8 0.58 11.2 3.3 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5302) Menin PF05053.13 KOG98325.1 - 3.4 5.9 7.1 4.1 5.7 7.1 1.0 1 0 0 1 1 1 0 Menin Bromodomain PF00439.25 KOG98326.1 - 5e-30 103.4 6.5 4.5e-20 71.5 0.3 2.7 2 0 0 2 2 2 2 Bromodomain adh_short PF00106.25 KOG98327.1 - 8.7e-84 279.8 8.6 1.6e-43 148.4 0.4 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOG98327.1 - 2.3e-67 227.0 2.4 1.3e-35 123.1 0.1 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 KOG98327.1 - 9.8e-37 125.3 0.0 1.9e-36 124.3 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 KOG98327.1 - 3.1e-34 118.4 3.1 2.8e-17 63.2 0.1 2.2 2 0 0 2 2 2 2 KR domain MaoC_dehydrat_N PF13452.6 KOG98327.1 - 0.002 18.3 0.0 0.088 12.9 0.0 2.5 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase 2-Hacid_dh_C PF02826.19 KOG98327.1 - 0.042 13.2 1.7 0.12 11.7 0.0 2.4 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 KOG98327.1 - 0.37 10.7 3.8 3.2 7.6 0.0 3.0 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PglL_A PF15864.5 KOG98327.1 - 2.2 8.1 8.0 5.4 6.8 1.0 2.5 2 0 0 2 2 2 0 Protein glycosylation ligase Cytokin_check_N PF10407.9 KOG98328.1 - 7.6e-27 93.1 1.9 2.9e-26 91.2 1.9 2.1 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus CAP PF00188.26 KOG98330.1 - 1.8e-14 54.6 3.1 1.8e-14 54.6 3.1 2.1 2 1 1 3 3 3 1 Cysteine-rich secretory protein family Ndc1_Nup PF09531.10 KOG98330.1 - 0.25 10.0 15.4 0.31 9.7 15.4 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOG2 PF10428.9 KOG98330.1 - 0.87 8.7 37.6 1.3 8.1 37.6 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein Hamartin PF04388.12 KOG98330.1 - 4.1 6.0 36.7 5.1 5.6 36.7 1.1 1 0 0 1 1 1 0 Hamartin protein CytochromB561_N PF09786.9 KOG98330.1 - 5.4 5.9 25.9 6.3 5.7 25.9 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal Ras PF00071.22 KOG98331.1 - 9e-55 184.7 0.1 1.1e-54 184.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG98331.1 - 1.7e-35 121.9 0.0 2.7e-35 121.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG98331.1 - 1e-12 47.9 0.1 1.9e-12 47.0 0.1 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOG98331.1 - 1.1e-05 25.1 0.1 1.8e-05 24.4 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOG98331.1 - 2.8e-05 24.2 0.0 5.2e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOG98331.1 - 0.00042 19.7 0.0 0.00067 19.1 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KOG98331.1 - 0.014 15.3 0.7 0.82 9.5 0.0 2.7 2 1 0 2 2 2 0 RsgA GTPase Septin PF00735.18 KOG98331.1 - 0.033 13.5 0.0 0.061 12.6 0.0 1.4 1 0 0 1 1 1 0 Septin TniB PF05621.11 KOG98331.1 - 0.038 13.4 0.0 0.069 12.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 KOG98331.1 - 0.048 14.0 0.2 0.093 13.1 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain Raptor_N PF14538.6 KOG98331.1 - 0.13 12.2 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain Mitofilin PF09731.9 KOG98333.1 - 2.1e-36 126.0 30.1 1.8e-19 70.1 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial inner membrane protein DUF4954 PF16314.5 KOG98333.1 - 0.07 11.3 8.5 0.029 12.5 0.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4954) HDAC4_Gln PF12203.8 KOG98333.1 - 0.55 10.4 12.6 0.87 9.8 10.3 2.1 1 1 1 2 2 2 0 Glutamine rich N terminal domain of histone deacetylase 4 DALR_1 PF05746.15 KOG98333.1 - 1.5 9.0 9.2 1.6 8.9 0.4 3.7 2 1 1 3 3 3 0 DALR anticodon binding domain IBR PF01485.21 KOG98334.1 - 3e-19 69.0 41.7 1.3e-10 41.3 4.3 4.0 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 KOG98334.1 - 2.8e-05 23.9 13.8 2.8e-05 23.9 13.8 4.7 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) DUF3808 PF10300.9 KOG98335.1 - 3e-180 600.1 0.1 3.5e-180 599.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_16 PF13432.6 KOG98335.1 - 0.019 15.6 3.0 1.7 9.4 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOG98335.1 - 0.029 14.5 0.9 39 4.7 0.0 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOG98335.1 - 0.21 11.8 1.8 30 4.9 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 KOG98335.1 - 0.38 10.4 2.4 0.9 9.2 0.1 2.7 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_19 PF14559.6 KOG98335.1 - 0.84 10.2 12.0 0.95 10.0 0.1 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat EF-hand_4 PF12763.7 KOG98336.1 - 0.022 14.7 0.7 0.065 13.2 0.0 2.1 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Vps51 PF08700.11 KOG98337.1 - 6e-11 42.3 4.9 6e-11 42.3 4.9 1.7 2 0 0 2 2 2 1 Vps51/Vps67 YtxH PF12732.7 KOG98337.1 - 0.0067 16.9 6.7 0.65 10.6 0.2 2.8 3 0 0 3 3 3 2 YtxH-like protein HBS1_N PF08938.10 KOG98337.1 - 0.01 16.1 3.6 0.02 15.2 3.6 1.6 1 1 0 1 1 1 1 HBS1 N-terminus DUF4050 PF13259.6 KOG98337.1 - 0.037 14.4 0.2 0.048 14.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Rotamase_2 PF13145.6 KOG98337.1 - 0.095 13.5 1.3 0.14 13.0 1.3 1.2 1 0 0 1 1 1 0 PPIC-type PPIASE domain Zw10 PF06248.13 KOG98337.1 - 0.11 11.0 5.9 0.014 14.0 2.0 1.5 2 0 0 2 2 2 0 Centromere/kinetochore Zw10 Arrestin_C PF02752.22 KOG98338.1 - 3.2e-18 66.5 0.5 2e-14 54.2 0.1 3.0 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 KOG98338.1 - 6.6e-06 26.2 1.6 0.00051 20.1 0.1 3.0 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain NTR2 PF15458.6 KOG98339.1 - 2.8e-119 398.3 24.0 3.1e-119 398.1 24.0 1.0 1 0 0 1 1 1 1 Nineteen complex-related protein 2 NPAT_C PF15712.5 KOG98339.1 - 0.07 11.8 3.4 0.091 11.4 3.4 1.1 1 0 0 1 1 1 0 NPAT C terminus zf-C2HC5 PF06221.13 KOG98340.1 - 6.5e-20 70.9 7.6 1.1e-19 70.1 7.6 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type DEAD PF00270.29 KOG98341.1 - 4e-41 140.7 0.0 6.8e-41 140.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.6 KOG98341.1 - 5.1e-19 68.3 0.1 1.3e-18 67.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 KOG98341.1 - 5.3e-17 62.2 0.0 1.4e-16 60.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG98341.1 - 7.1e-08 32.6 0.0 1.5e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3450 PF11932.8 KOG98341.1 - 0.14 11.5 0.0 0.41 9.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Sin_N PF04801.13 KOG98342.1 - 2.2e-17 63.4 0.5 4.8e-17 62.3 0.5 1.6 1 1 0 1 1 1 1 Sin-like protein conserved region PDCD2_C PF04194.13 KOG98342.1 - 0.85 9.7 6.8 7.6 6.6 1.6 2.2 2 0 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain IF-2B PF01008.17 KOG98343.1 - 5.1e-81 272.0 0.0 5.8e-81 271.8 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DeoRC PF00455.22 KOG98343.1 - 0.092 12.7 0.1 6 6.8 0.0 2.4 2 0 0 2 2 2 0 DeoR C terminal sensor domain ChAPs PF09295.10 KOG98344.1 - 1.5e-42 146.1 4.4 1.2e-34 120.1 1.1 2.1 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_2 PF07719.17 KOG98344.1 - 0.014 15.4 0.0 6 7.2 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOG98344.1 - 0.018 15.3 0.0 0.092 13.0 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 KOG98344.1 - 0.077 13.3 0.1 66 4.1 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat SAPS PF04499.15 KOG98345.1 - 7.7e-175 582.3 3.0 7.7e-175 582.3 3.0 3.3 4 0 0 4 4 4 1 SIT4 phosphatase-associated protein DUF4934 PF16288.5 KOG98345.1 - 0.079 12.9 0.0 3.7 7.5 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4934) PHD PF00628.29 KOG98346.1 - 1.9e-10 40.5 9.1 3.8e-10 39.5 9.1 1.5 1 0 0 1 1 1 1 PHD-finger SET PF00856.28 KOG98346.1 - 2.8e-05 24.6 6.5 3.1e-05 24.4 3.4 2.8 2 1 0 2 2 2 1 SET domain PHD_2 PF13831.6 KOG98346.1 - 0.00026 20.5 3.3 0.00052 19.5 3.3 1.5 1 0 0 1 1 1 1 PHD-finger zf-CW PF07496.15 KOG98346.1 - 0.057 13.5 2.2 0.16 12.0 2.2 1.8 1 0 0 1 1 1 0 CW-type Zinc Finger UNC-50 PF05216.13 KOG98347.1 - 1e-84 283.6 21.5 1.2e-84 283.4 21.5 1.0 1 0 0 1 1 1 1 UNC-50 family PLDc PF00614.22 KOG98348.1 - 1e-18 66.6 0.0 4.2e-09 36.2 0.0 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 KOG98348.1 - 5.1e-09 36.1 5.6 4.2e-06 26.7 0.1 4.1 4 1 0 4 4 4 2 PLD-like domain PX PF00787.24 KOG98348.1 - 0.00078 19.4 4.8 0.0056 16.6 0.7 3.6 3 0 0 3 3 3 1 PX domain CCAP PF11105.8 KOG98348.1 - 0.064 13.2 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a GATA PF00320.27 KOG98349.1 - 2.4e-15 55.8 1.4 4.8e-15 54.9 1.4 1.6 1 0 0 1 1 1 1 GATA zinc finger ArfGap PF01412.18 KOG98349.1 - 0.0083 16.2 1.2 0.014 15.4 1.2 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf TF_Zn_Ribbon PF08271.12 KOG98349.1 - 0.1 12.1 0.5 0.22 11.1 0.5 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Auto_anti-p27 PF06677.12 KOG98349.1 - 0.19 11.9 1.2 0.34 11.1 1.2 1.4 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Snf7 PF03357.21 KOG98350.1 - 1.8e-09 37.5 19.7 1.8e-09 37.5 19.7 1.4 2 0 0 2 2 2 1 Snf7 T7SS_ESX_EspC PF10824.8 KOG98350.1 - 0.033 14.7 1.6 0.055 13.9 0.1 2.2 3 0 0 3 3 3 0 Excreted virulence factor EspC, type VII ESX diderm ECH_2 PF16113.5 KOG98350.1 - 0.31 10.5 5.2 0.37 10.3 5.2 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase DUF948 PF06103.11 KOG98350.1 - 0.66 10.3 9.7 0.74 10.1 0.8 2.9 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) GrpE PF01025.19 KOG98350.1 - 1.4 8.5 14.5 0.23 11.1 10.1 1.8 1 1 1 2 2 2 0 GrpE Fzo_mitofusin PF04799.13 KOG98350.1 - 5.7 6.5 13.0 6.8 6.2 0.8 2.2 1 1 1 2 2 2 0 fzo-like conserved region Caf4 PF11615.8 KOG98351.1 - 7.7e-31 105.9 0.2 1.6e-30 104.8 0.2 1.6 1 0 0 1 1 1 1 CCR4-associated factor 4 WD40 PF00400.32 KOG98351.1 - 9.6e-27 92.7 10.0 5.4e-07 30.2 0.0 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG98351.1 - 1.5e-07 31.6 0.1 1 9.7 0.0 5.4 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOG98351.1 - 9.7e-05 21.8 0.9 0.0033 16.8 0.0 3.0 2 1 1 3 3 3 1 WD40-like domain Nup160 PF11715.8 KOG98351.1 - 0.00022 20.0 7.2 1.1 7.8 0.1 4.4 2 1 3 5 5 5 3 Nucleoporin Nup120/160 TRAF_BIRC3_bd PF16673.5 KOG98351.1 - 0.28 11.0 0.9 3.6 7.5 0.1 2.4 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain DASH_Spc34 PF08657.10 KOG98352.1 - 6.6e-84 281.7 1.1 7.5e-84 281.5 1.1 1.0 1 0 0 1 1 1 1 DASH complex subunit Spc34 Cep57_MT_bd PF06657.13 KOG98352.1 - 0.0019 18.6 0.7 0.55 10.7 0.1 3.0 4 0 0 4 4 4 1 Centrosome microtubule-binding domain of Cep57 IFT20 PF14931.6 KOG98352.1 - 0.015 15.4 0.3 0.028 14.6 0.3 1.4 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 PRKG1_interact PF15898.5 KOG98352.1 - 0.28 12.1 3.2 0.91 10.5 3.2 1.8 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain ZapB PF06005.12 KOG98352.1 - 0.34 11.4 3.8 7.2 7.1 1.0 2.9 3 0 0 3 3 3 0 Cell division protein ZapB Peptidase_M22 PF00814.25 KOG98353.1 - 5.3e-86 288.7 0.0 6.5e-86 288.4 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 KOG98353.1 - 0.04 13.6 0.1 0.08 12.6 0.1 1.4 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus AA_permease PF00324.21 KOG98354.1 - 7.9e-159 529.3 35.3 9.9e-159 529.0 35.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG98354.1 - 1.4e-42 146.0 36.0 2e-42 145.5 36.0 1.1 1 0 0 1 1 1 1 Amino acid permease Orthopox_A5L PF06193.11 KOG98355.1 - 0.007 15.8 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Orthopoxvirus A5L protein-like DnaJ PF00226.31 KOG98355.1 - 0.052 13.7 0.1 0.13 12.4 0.1 1.7 1 0 0 1 1 1 0 DnaJ domain MFAP1 PF06991.11 KOG98355.1 - 4.5 7.0 18.2 0.28 11.0 12.0 2.1 2 1 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing SUN PF03856.13 KOG98356.1 - 2.9e-98 328.2 15.8 4.5e-98 327.6 15.8 1.3 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) SR-25 PF10500.9 KOG98356.1 - 6.4 6.3 6.5 11 5.5 6.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein His_Phos_1 PF00300.22 KOG98357.1 - 1.9e-33 115.8 0.2 2.5e-33 115.4 0.2 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Lectin_leg-like PF03388.13 KOG98358.1 - 1.1e-15 57.6 0.0 6.5e-07 28.9 0.0 2.2 2 0 0 2 2 2 2 Legume-like lectin family Bact_lectin PF18483.1 KOG98358.1 - 7.9e-06 26.0 0.6 1.1e-05 25.6 0.6 1.2 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 KOG98358.1 - 0.00023 20.8 0.5 0.0004 20.0 0.5 1.4 1 1 0 1 1 1 1 Legume lectin domain Med3 PF11593.8 KOG98359.1 - 0.0073 15.5 11.7 0.0095 15.2 11.7 1.2 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal TFIIA PF03153.13 KOG98359.1 - 0.021 14.9 13.0 0.022 14.8 13.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 KOG98359.1 - 0.083 12.0 3.1 0.088 11.9 3.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Androgen_recep PF02166.16 KOG98359.1 - 0.086 11.7 9.2 0.099 11.5 9.2 1.2 1 0 0 1 1 1 0 Androgen receptor F1F0-ATPsyn_F PF10791.9 KOG98359.1 - 0.15 12.5 0.1 0.3 11.6 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi Suf PF05843.14 KOG98359.1 - 0.26 11.3 5.4 0.27 11.2 5.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4834 PF16118.5 KOG98359.1 - 0.39 11.7 4.1 0.12 13.4 1.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) FlaG PF03646.15 KOG98359.1 - 9.3 6.5 13.0 1.1e+02 3.1 13.0 2.3 1 1 0 1 1 1 0 FlaG protein UPF0524 PF15823.5 KOG98359.1 - 9.7 5.5 8.6 2.8 7.3 5.3 1.6 1 1 1 2 2 2 0 UPF0524 of C3orf70 PET10 PF17316.2 KOG98360.1 - 1.8e-106 355.3 0.2 2e-106 355.1 0.2 1.0 1 0 0 1 1 1 1 Petite colonies protein 10 NAP PF00956.18 KOG98361.1 - 7.1e-85 284.4 3.1 7.1e-85 284.4 3.1 2.1 3 0 0 3 3 3 1 Nucleosome assembly protein (NAP) Cwf_Cwc_15 PF04889.12 KOG98361.1 - 0.38 10.4 26.0 0.62 9.8 16.1 3.2 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein DUF1687 PF07955.11 KOG98362.1 - 1.3e-27 96.8 0.6 1.6e-27 96.5 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) TrkH PF02386.16 KOG98363.1 - 3.3e-192 639.4 0.2 3.6e-190 632.7 0.0 2.1 2 0 0 2 2 2 2 Cation transport protein Solute_trans_a PF03619.16 KOG98364.1 - 3e-75 253.2 12.7 3.7e-75 252.9 12.7 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Mito_carr PF00153.27 KOG98365.1 - 1.6e-58 194.6 3.4 3e-20 71.9 0.2 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein PAP2 PF01569.21 KOG98366.1 - 3.9e-14 52.6 3.1 3.9e-14 52.6 3.1 1.8 2 0 0 2 2 2 1 PAP2 superfamily Fer4_5 PF12801.7 KOG98366.1 - 0.049 13.6 3.4 0.24 11.4 3.4 2.3 1 0 0 1 1 1 0 4Fe-4S binding domain AAA_6 PF12774.7 KOG98367.1 - 5.4e-98 328.0 0.0 5.4e-98 328.0 0.0 3.9 5 0 0 5 5 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOG98367.1 - 1.3e-83 281.3 13.7 1.3e-83 281.3 13.7 6.8 7 1 0 7 7 4 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 KOG98367.1 - 5.3e-54 182.7 3.9 5.3e-54 182.7 3.9 3.6 3 0 0 3 3 2 1 ATP-binding dynein motor region DHC_N1 PF08385.12 KOG98367.1 - 1.4e-48 166.0 23.0 1.4e-48 166.0 23.0 5.8 5 1 0 5 5 4 1 Dynein heavy chain, N-terminal region 1 AAA_8 PF12780.7 KOG98367.1 - 1.1e-42 146.2 3.8 1.5e-41 142.5 0.2 4.3 3 0 0 3 3 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 KOG98367.1 - 4.6e-39 133.8 0.5 4e-32 111.2 0.0 4.8 4 0 0 4 4 4 3 P-loop containing dynein motor region MT PF12777.7 KOG98367.1 - 2.8e-23 82.5 9.0 5.2e-23 81.6 9.0 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 KOG98367.1 - 9.3e-23 80.8 2.7 9.2e-07 28.9 0.0 6.8 6 1 0 6 6 5 3 AAA domain (dynein-related subfamily) AAA_lid_11 PF18198.1 KOG98367.1 - 3.8e-18 65.8 0.0 1.9e-17 63.6 0.0 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KOG98367.1 - 1.3e-15 57.5 0.9 3.8e-12 46.3 0.0 4.8 5 0 0 5 5 4 1 Dynein heavy chain region D6 P-loop domain AAA PF00004.29 KOG98367.1 - 9.2e-14 52.0 12.3 0.0012 19.2 0.0 8.4 8 0 0 8 8 7 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOG98367.1 - 7.4e-12 45.7 18.0 0.00029 21.1 0.0 8.4 8 1 1 9 9 6 4 AAA domain AAA_16 PF13191.6 KOG98367.1 - 6.8e-10 39.6 4.2 0.61 10.5 0.0 6.7 6 1 1 7 7 7 2 AAA ATPase domain AAA_lid_1 PF17857.1 KOG98367.1 - 7.5e-08 32.5 0.1 8.5e-06 25.9 0.0 3.5 2 0 0 2 2 2 1 AAA+ lid domain AAA_30 PF13604.6 KOG98367.1 - 5.1e-06 26.3 1.2 0.73 9.5 0.0 4.6 4 1 0 4 4 4 1 AAA domain T2SSE PF00437.20 KOG98367.1 - 1.2e-05 24.5 1.8 1.4 7.9 0.0 5.0 5 0 0 5 5 5 2 Type II/IV secretion system protein AAA_33 PF13671.6 KOG98367.1 - 4.3e-05 23.7 0.4 0.43 10.7 0.0 4.8 4 0 0 4 4 4 1 AAA domain IstB_IS21 PF01695.17 KOG98367.1 - 6.7e-05 22.7 0.1 0.15 11.8 0.0 4.1 3 0 0 3 3 3 1 IstB-like ATP binding protein RNA_helicase PF00910.22 KOG98367.1 - 8.9e-05 22.8 0.3 5.3 7.5 0.0 4.9 4 0 0 4 4 4 0 RNA helicase AAA_19 PF13245.6 KOG98367.1 - 0.0001 22.6 5.2 3.6 7.9 0.0 5.6 4 1 0 4 4 4 1 AAA domain Zeta_toxin PF06414.12 KOG98367.1 - 0.00011 21.5 0.0 1.6 8.0 0.0 3.9 4 0 0 4 4 4 1 Zeta toxin AAA_24 PF13479.6 KOG98367.1 - 0.00012 21.9 2.4 0.47 10.1 0.0 4.9 5 0 0 5 5 4 1 AAA domain TsaE PF02367.17 KOG98367.1 - 0.00021 21.3 1.1 27 4.8 0.0 5.0 5 0 0 5 5 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 KOG98367.1 - 0.00048 20.4 0.1 9.7 6.4 0.0 4.1 3 0 0 3 3 3 0 AAA domain BRE1 PF08647.11 KOG98367.1 - 0.00092 19.2 7.3 0.00092 19.2 7.3 5.8 5 0 0 5 5 4 1 BRE1 E3 ubiquitin ligase ABC_tran PF00005.27 KOG98367.1 - 0.003 18.1 3.0 1.2 9.6 0.0 5.1 5 0 0 5 5 4 1 ABC transporter FtsK_SpoIIIE PF01580.18 KOG98367.1 - 0.0076 15.6 0.0 2.6 7.3 0.0 3.5 3 0 0 3 3 3 1 FtsK/SpoIIIE family cobW PF02492.19 KOG98367.1 - 0.013 15.1 0.1 0.15 11.6 0.0 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 KOG98367.1 - 0.014 15.6 3.9 5.9 7.1 0.0 4.7 5 0 0 5 5 4 0 Ras of Complex, Roc, domain of DAPkinase Mg_chelatase PF01078.21 KOG98367.1 - 0.015 14.7 0.6 1.2 8.5 0.0 3.5 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KOG98367.1 - 0.016 15.8 18.4 0.59 10.7 0.0 6.1 8 0 0 8 8 4 0 AAA domain NACHT PF05729.12 KOG98367.1 - 0.096 12.6 3.3 15 5.4 0.0 4.0 4 0 0 4 4 4 0 NACHT domain AAA_29 PF13555.6 KOG98367.1 - 0.11 12.3 0.2 43 4.0 0.0 3.7 4 0 0 4 4 3 0 P-loop containing region of AAA domain PduV-EutP PF10662.9 KOG98367.1 - 0.11 12.2 1.1 5.1 6.8 0.1 3.5 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DASH_Dad1 PF08649.10 KOG98367.1 - 0.11 12.6 3.4 3.9 7.7 0.2 4.7 3 0 0 3 3 3 0 DASH complex subunit Dad1 AAA_25 PF13481.6 KOG98367.1 - 0.18 11.3 0.1 5.4 6.5 0.0 2.9 2 0 0 2 2 2 0 AAA domain Phe_ZIP PF08916.11 KOG98367.1 - 0.2 12.4 1.9 0.62 10.8 0.3 2.7 3 0 0 3 3 1 0 Phenylalanine zipper ResIII PF04851.15 KOG98367.1 - 7.2 6.6 29.0 1.2 9.1 0.1 7.0 6 1 0 7 7 6 0 Type III restriction enzyme, res subunit Ras PF00071.22 KOG98368.1 - 7.5e-52 175.2 0.0 1.1e-51 174.6 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG98368.1 - 1.4e-24 86.6 0.0 2.4e-24 85.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG98368.1 - 4.1e-06 26.4 0.0 7.1e-06 25.6 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family tRNA_U5-meth_tr PF05958.11 KOG98369.1 - 9e-22 77.5 0.2 1e-20 74.0 0.2 2.1 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase TRAM PF01938.20 KOG98369.1 - 6.9e-11 42.0 0.3 1.4e-10 41.0 0.0 1.6 2 0 0 2 2 1 1 TRAM domain Methyltransf_31 PF13847.6 KOG98369.1 - 5e-07 29.6 0.0 1.5e-06 28.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOG98369.1 - 1.9e-06 28.5 0.0 9.8e-06 26.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 KOG98369.1 - 5.2e-06 26.1 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 KOG98369.1 - 1.6e-05 24.5 0.0 4.4e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 KOG98369.1 - 0.0015 18.3 0.2 0.0065 16.2 0.0 2.1 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_11 PF08241.12 KOG98369.1 - 0.0017 18.9 0.0 0.028 15.1 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KOG98369.1 - 0.0021 17.6 0.2 0.0053 16.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.18 KOG98369.1 - 0.0025 17.2 0.0 0.0065 15.8 0.0 1.7 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 KOG98369.1 - 0.017 14.6 0.0 0.055 12.9 0.0 1.8 1 0 0 1 1 1 0 Putative methyltransferase Peptidase_S49_N PF08496.10 KOG98369.1 - 0.21 11.7 0.8 0.4 10.7 0.8 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ribosomal_S21e PF01249.18 KOG98370.1 - 3.9e-40 135.8 0.0 4.3e-40 135.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Glyco_hydro2_C5 PF18565.1 KOG98370.1 - 0.045 13.6 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 Invasin_D3 PF09134.10 KOG98370.1 - 0.1 12.9 0.0 0.12 12.7 0.0 1.1 1 0 0 1 1 1 0 Invasin, domain 3 Glyco_transf_8 PF01501.20 KOG98371.1 - 2e-33 116.0 0.3 5.3e-33 114.7 0.1 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 8 DEAD PF00270.29 KOG98372.1 - 1.4e-43 148.7 1.5 1.6e-43 148.5 0.4 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG98372.1 - 1.7e-31 108.8 0.3 1.2e-30 106.1 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG98372.1 - 6.5e-08 32.8 0.0 1.4e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KOG98372.1 - 0.00058 20.2 0.2 0.0035 17.7 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOG98372.1 - 0.00093 19.0 0.1 0.0016 18.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain Ribosomal_L1 PF00687.21 KOG98373.1 - 1.7e-44 152.0 1.3 2.2e-44 151.7 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Glyco_transf_15 PF01793.16 KOG98374.1 - 9.6e-105 350.4 12.3 1.3e-104 350.0 12.3 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase TFA2_Winged_2 PF18121.1 KOG98375.1 - 2.6e-20 71.9 1.0 6e-20 70.7 0.1 2.1 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 KOG98375.1 - 5.9e-17 61.7 0.6 1.4e-16 60.5 0.6 1.7 1 0 0 1 1 1 1 TFIIE beta subunit core domain DUF3246 PF11596.8 KOG98375.1 - 0.13 11.7 2.1 0.22 10.9 2.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) HTH_15 PF12324.8 KOG98375.1 - 0.18 11.8 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase Las1 PF04031.13 KOG98376.1 - 2e-48 164.4 0.1 4.5e-48 163.2 0.1 1.6 1 0 0 1 1 1 1 Las1-like DUF4111 PF13427.6 KOG98376.1 - 0.0068 16.5 0.0 0.024 14.8 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4111) GCR1_C PF12550.8 KOG98376.1 - 0.73 10.2 5.3 0.19 12.1 0.9 2.3 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes Pam17 PF08566.10 KOG98377.1 - 9.9e-66 220.7 0.0 1.2e-65 220.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 BPD_transp_2 PF02653.16 KOG98377.1 - 0.012 14.8 0.1 0.017 14.3 0.1 1.1 1 0 0 1 1 1 0 Branched-chain amino acid transport system / permease component peroxidase PF00141.23 KOG98378.1 - 1.4e-42 146.0 0.0 2.4e-42 145.2 0.0 1.4 1 0 0 1 1 1 1 Peroxidase Acyltransferase PF01553.21 KOG98379.1 - 1.5e-05 24.6 0.0 9.2e-05 22.1 0.0 2.2 1 1 0 1 1 1 1 Acyltransferase PHO4 PF01384.20 KOG98379.1 - 0.18 10.8 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 Phosphate transporter family TRAPP PF04051.16 KOG98380.1 - 2e-33 115.2 0.0 2.4e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Dsl1_N PF11988.8 KOG98380.1 - 0.0032 16.5 1.3 0.005 15.9 0.1 1.9 3 0 0 3 3 3 1 Retrograde transport protein Dsl1 N terminal TP_methylase PF00590.20 KOG98381.1 - 2.5e-40 138.7 0.0 4e-40 138.0 0.0 1.3 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sirohm_synth_M PF14824.6 KOG98381.1 - 4.7e-06 25.9 0.0 9.2e-06 25.0 0.0 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central NAD_binding_7 PF13241.6 KOG98381.1 - 0.00071 20.0 0.0 0.0031 17.9 0.0 2.0 2 0 0 2 2 2 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 KOG98381.1 - 0.045 13.4 0.3 0.13 11.9 0.3 1.7 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal CTF_NFI PF00859.18 KOG98381.1 - 0.052 13.5 1.1 0.078 12.9 1.1 1.2 1 0 0 1 1 1 0 CTF/NF-I family transcription modulation region Hydrolase_like PF13242.6 KOG98382.1 - 2e-26 91.9 0.0 4e-26 90.9 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 KOG98382.1 - 1.7e-25 89.0 0.0 2.9e-25 88.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOG98382.1 - 0.00038 20.6 0.0 0.078 13.1 0.0 3.0 3 1 1 4 4 4 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOG98382.1 - 0.0024 18.2 0.1 5.3 7.3 0.0 3.5 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase CIAPIN1 PF05093.13 KOG98383.1 - 3.3e-39 133.4 5.4 1e-38 131.8 5.4 1.9 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 KOG98383.1 - 8.5e-32 110.2 0.2 1.3e-31 109.5 0.2 1.3 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus zf-CSL PF05207.13 KOG98383.1 - 1.1 9.1 6.1 5.8 6.7 5.3 2.6 1 1 0 1 1 1 0 CSL zinc finger Flavoprotein PF02441.19 KOG98384.1 - 7.4e-55 185.0 0.1 1.4e-54 184.1 0.1 1.5 1 0 0 1 1 1 1 Flavoprotein PPP4R2 PF09184.11 KOG98384.1 - 0.0002 21.0 20.3 0.0002 21.0 20.3 2.4 2 1 0 2 2 2 1 PPP4R2 Nop14 PF04147.12 KOG98384.1 - 0.13 10.5 35.0 0.19 9.9 35.0 1.3 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 KOG98384.1 - 0.16 11.4 31.8 0.29 10.5 31.8 1.4 1 0 0 1 1 1 0 SDA1 DUF2076 PF09849.9 KOG98384.1 - 0.17 11.9 17.7 0.33 10.9 17.7 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Mpp10 PF04006.12 KOG98384.1 - 0.2 10.1 26.5 0.36 9.2 26.5 1.3 1 0 0 1 1 1 0 Mpp10 protein Afi1 PF07792.12 KOG98384.1 - 0.26 11.7 16.5 0.028 14.9 11.9 1.8 2 0 0 2 2 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RRN3 PF05327.11 KOG98384.1 - 0.46 9.0 24.9 0.69 8.4 24.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CobT PF06213.12 KOG98384.1 - 0.71 9.2 30.2 1.2 8.4 30.2 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Tim54 PF11711.8 KOG98384.1 - 0.82 8.4 12.0 0.073 11.8 5.8 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 BUD22 PF09073.10 KOG98384.1 - 2.5 7.4 30.4 5.7 6.2 30.4 1.6 1 0 0 1 1 1 0 BUD22 DUF913 PF06025.12 KOG98384.1 - 2.6 6.9 6.5 6.6 5.6 6.5 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2340 PF10209.9 KOG98385.1 - 1.9e-54 183.2 2.1 2.5e-54 182.8 2.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) Peptidase_C13 PF01650.18 KOG98385.1 - 0.0068 16.0 0.5 0.011 15.3 0.4 1.4 1 1 1 2 2 2 1 Peptidase C13 family Innate_immun PF12782.7 KOG98386.1 - 1.7 8.1 8.6 2.6 7.5 8.6 1.2 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family GST_N_2 PF13409.6 KOG98387.1 - 1.8e-24 85.8 0.0 4.8e-24 84.5 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOG98387.1 - 1.3e-12 47.6 0.0 2.6e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOG98387.1 - 0.0055 16.9 0.0 0.016 15.4 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOG98387.1 - 0.014 15.8 0.1 4.8 7.7 0.0 2.6 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KOG98387.1 - 0.018 15.3 0.2 0.048 13.8 0.2 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Vps5 PF09325.10 KOG98389.1 - 1.9e-25 89.8 12.2 3.3e-25 89.0 12.2 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 KOG98389.1 - 1.8e-14 53.7 5.1 2.2e-14 53.4 0.3 3.1 3 1 1 4 4 4 1 PX domain RPAP1_N PF08621.10 KOG98389.1 - 0.043 13.6 0.7 0.098 12.4 0.1 1.9 2 0 0 2 2 2 0 RPAP1-like, N-terminal Lactamase_B_4 PF13691.6 KOG98390.1 - 5.4e-27 93.3 0.0 1.2e-26 92.2 0.0 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 KOG98390.1 - 1.5e-11 44.2 0.0 0.0002 20.9 0.0 3.2 3 0 0 3 3 3 2 Beta-lactamase superfamily domain THF_DHG_CYH PF00763.23 KOG98391.1 - 1.9e-22 79.7 0.0 4.4e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 KOG98391.1 - 7.9e-18 64.3 0.0 1.5e-14 53.7 0.0 2.5 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain CdiI_N PF18228.1 KOG98391.1 - 0.019 14.8 0.1 5.6 6.8 0.1 2.3 2 0 0 2 2 2 0 CdiI N-terminal domain Brix PF04427.18 KOG98392.1 - 4.7e-39 134.5 1.1 6.5e-39 134.0 1.1 1.2 1 0 0 1 1 1 1 Brix domain Nucleoporin_N PF08801.11 KOG98393.1 - 5.7e-66 223.0 10.7 8.4e-66 222.5 10.7 1.2 1 0 0 1 1 1 1 Nup133 N terminal like CHAP PF05257.16 KOG98393.1 - 0.039 14.5 0.0 0.12 13.0 0.0 1.8 1 0 0 1 1 1 0 CHAP domain DASH_Dad2 PF08654.10 KOG98394.1 - 6.3e-28 97.1 7.6 1.5e-27 95.9 7.6 1.5 1 1 0 1 1 1 1 DASH complex subunit Dad2 DASH_Duo1 PF08651.10 KOG98394.1 - 0.0013 18.4 2.8 0.002 17.8 2.8 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 CENP-B_dimeris PF09026.10 KOG98394.1 - 0.14 12.6 5.8 0.22 11.9 5.8 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NINJA_B PF16136.5 KOG98394.1 - 0.39 11.1 4.6 6.4 7.2 0.8 2.3 2 1 0 2 2 2 0 Putative nuclear localisation signal GTP_EFTU PF00009.27 KOG98395.1 - 8.9e-44 149.4 0.0 1.5e-43 148.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 KOG98395.1 - 1e-12 48.1 1.4 1e-12 48.1 1.4 2.2 2 0 0 2 2 2 1 HBS1 N-terminus MMR_HSR1 PF01926.23 KOG98395.1 - 4.6e-08 33.1 0.0 0.0007 19.7 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU_D3 PF03143.17 KOG98395.1 - 5.4e-08 33.1 0.5 3.1e-07 30.7 0.0 2.5 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KOG98395.1 - 6.2e-05 23.3 0.1 0.00019 21.7 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Roc PF08477.13 KOG98395.1 - 0.0019 18.4 0.1 0.4 10.9 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOG98395.1 - 0.01 15.4 0.5 0.15 11.7 0.0 2.5 3 0 0 3 3 3 0 Ras family RsgA_GTPase PF03193.16 KOG98395.1 - 0.012 15.5 0.1 1.2 9.0 0.0 2.7 2 1 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 KOG98395.1 - 0.015 15.3 0.3 4.3 7.4 0.0 3.0 2 1 1 3 3 3 0 Dynamin family FeoB_N PF02421.18 KOG98395.1 - 0.1 12.1 0.1 2.1 7.9 0.1 2.8 2 1 0 2 2 2 0 Ferrous iron transport protein B MRP-L20 PF12824.7 KOG98396.1 - 2e-43 148.4 2.9 2.4e-43 148.1 2.9 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 GGACT PF06094.12 KOG98396.1 - 0.08 13.5 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like HTH_38 PF13936.6 KOG98396.1 - 0.1 12.3 0.0 0.26 11.1 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain HA2 PF04408.23 KOG98397.1 - 1.8e-21 76.4 0.2 6.6e-21 74.6 0.0 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KOG98397.1 - 2.4e-15 56.7 0.0 6.2e-15 55.3 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KOG98397.1 - 6.9e-14 52.1 0.1 2.1e-13 50.6 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOG98397.1 - 7.9e-08 32.3 0.4 2.1e-07 30.9 0.1 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOG98397.1 - 4e-07 30.4 0.1 2e-06 28.1 0.1 2.2 2 0 0 2 2 1 1 AAA domain AAA_19 PF13245.6 KOG98397.1 - 0.00012 22.4 0.0 0.00034 21.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOG98397.1 - 0.0004 20.2 0.0 0.00074 19.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 KOG98397.1 - 0.00099 18.4 0.3 0.0021 17.3 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Herpes_ori_bp PF02399.15 KOG98397.1 - 0.0017 16.5 0.2 0.005 15.0 0.1 1.7 2 0 0 2 2 2 1 Origin of replication binding protein PhoH PF02562.16 KOG98397.1 - 0.0017 17.8 0.0 0.005 16.3 0.0 1.7 1 0 0 1 1 1 1 PhoH-like protein IstB_IS21 PF01695.17 KOG98397.1 - 0.0043 16.8 0.1 1.8 8.3 0.0 2.4 1 1 0 2 2 2 1 IstB-like ATP binding protein AAA_14 PF13173.6 KOG98397.1 - 0.011 15.8 0.6 0.55 10.3 0.6 2.8 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 KOG98397.1 - 0.016 14.3 0.0 0.03 13.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ResIII PF04851.15 KOG98397.1 - 0.018 15.0 0.2 0.46 10.5 0.2 2.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit ABC_tran PF00005.27 KOG98397.1 - 0.02 15.4 0.0 0.078 13.5 0.0 2.0 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 KOG98397.1 - 0.032 14.7 9.0 0.29 11.6 0.1 3.1 3 1 0 3 3 2 0 AAA domain AAA_33 PF13671.6 KOG98397.1 - 0.033 14.4 0.0 0.082 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOG98397.1 - 0.039 13.5 0.0 0.089 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 KOG98397.1 - 0.04 13.6 0.0 0.089 12.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 KOG98397.1 - 0.046 13.8 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 KOG98397.1 - 0.052 13.3 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KOG98397.1 - 0.058 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 KaiC SRP54 PF00448.22 KOG98397.1 - 0.063 12.9 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Peptidase_M48 PF01435.18 KOG98398.1 - 8e-31 107.3 0.0 1.7e-30 106.3 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M48 SNARE_assoc PF09335.11 KOG98399.1 - 7.3e-15 55.5 11.1 2.6e-14 53.7 7.6 2.9 3 0 0 3 3 3 1 SNARE associated Golgi protein TctB PF07331.11 KOG98399.1 - 0.0062 16.8 10.7 0.0062 16.8 10.7 2.1 2 0 0 2 2 2 1 Tripartite tricarboxylate transporter TctB family Tetraspanin PF00335.20 KOG98399.1 - 0.54 9.9 6.0 5.4 6.7 4.1 2.3 2 0 0 2 2 2 0 Tetraspanin family Gram_pos_anchor PF00746.21 KOG98399.1 - 0.97 9.4 3.1 9.7 6.2 0.2 2.7 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DUF4231 PF14015.6 KOG98399.1 - 4 7.9 10.4 2.9 8.4 0.1 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) DUF3336 PF11815.8 KOG98400.1 - 4.8e-32 110.6 3.0 6.4e-32 110.1 1.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.22 KOG98400.1 - 3.7e-26 92.6 0.0 7.2e-26 91.6 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase DNA_pol_phi PF04931.13 KOG98400.1 - 6.6 4.7 10.6 11 4.0 10.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi LIM PF00412.22 KOG98401.1 - 2.5e-13 50.0 23.2 6.3e-08 32.7 8.7 2.4 2 0 0 2 2 2 2 LIM domain Cadherin_C PF01049.17 KOG98401.1 - 0.00056 20.3 3.0 0.00056 20.3 3.0 2.1 1 1 1 2 2 2 1 Cadherin cytoplasmic region Prothymosin PF03247.14 KOG98401.1 - 0.59 10.6 16.9 1.8 9.1 16.9 1.8 1 0 0 1 1 1 0 Prothymosin/parathymosin family Mfa1 PF17445.2 KOG98402.1 - 0.83 9.7 2.9 1.3 9.1 0.6 2.4 2 1 1 3 3 3 0 Mating factor A1 SRP40_C PF05022.12 KOG98403.1 - 1e-22 80.7 2.0 3.2e-22 79.2 2.0 1.9 1 0 0 1 1 1 1 SRP40, C-terminal domain PTR2 PF00854.21 KOG98404.1 - 2e-110 369.4 14.8 7.7e-110 367.4 14.8 1.8 1 1 0 1 1 1 1 POT family MFS_1 PF07690.16 KOG98404.1 - 1.1e-05 24.6 32.6 1.1e-05 24.6 32.6 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily TPR_MLP1_2 PF07926.12 KOG98405.1 - 5.6e-32 110.5 23.4 5.6e-32 110.5 23.4 17.9 5 3 11 18 18 18 7 TPR/MLP1/MLP2-like protein Cep57_CLD_2 PF14197.6 KOG98405.1 - 0.00035 20.6 6.5 0.00035 20.6 6.5 20.1 12 6 7 20 20 20 4 Centrosome localisation domain of PPC89 Pcc1 PF09341.10 KOG98406.1 - 1.7e-20 72.9 0.1 1.9e-20 72.8 0.1 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 PIN_4 PF13638.6 KOG98407.1 - 1.6e-11 44.6 0.4 1.6e-11 44.6 0.4 2.6 3 0 0 3 3 3 1 PIN domain PEPCK_ATP PF01293.20 KOG98408.1 - 3.4e-217 721.7 0.0 4e-217 721.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 KOG98408.1 - 0.05 13.8 0.0 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 KOG98408.1 - 0.061 12.7 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.6 KOG98408.1 - 0.15 11.8 0.1 0.42 10.4 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain SelA PF03841.13 KOG98408.1 - 0.24 10.4 0.2 1.3 7.9 0.1 1.9 2 0 0 2 2 2 0 L-seryl-tRNA selenium transferase UCH PF00443.29 KOG98409.1 - 5.8e-55 186.6 7.0 1.2e-54 185.6 7.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOG98409.1 - 2.2e-16 60.4 5.7 2.2e-16 60.4 5.7 2.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase SelP_N PF04592.14 KOG98409.1 - 0.14 11.6 17.5 0.22 10.9 10.1 2.5 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Rubredoxin_2 PF18073.1 KOG98409.1 - 4.1 7.2 6.1 14 5.5 1.7 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain Myb_DNA-binding PF00249.31 KOG98410.1 - 6.5e-29 99.9 8.2 8.8e-13 48.2 0.1 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOG98410.1 - 1.6e-27 95.5 2.0 8.6e-10 38.7 0.0 3.6 2 1 1 3 3 3 3 Myb-like DNA-binding domain SLIDE PF09111.10 KOG98410.1 - 0.0026 17.8 0.2 6.1 6.9 0.0 3.6 2 1 1 3 3 3 1 SLIDE SANT_DAMP1_like PF16282.5 KOG98410.1 - 0.032 14.4 0.8 3.1 8.1 0.1 3.5 3 1 1 4 4 4 0 SANT/Myb-like domain of DAMP1 DUF5556 PF17711.1 KOG98410.1 - 0.035 14.0 0.0 0.072 13.0 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5556) Rap1_C PF11626.8 KOG98410.1 - 0.039 14.0 1.4 4.2 7.5 0.1 2.7 1 1 1 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain SKG6 PF08693.10 KOG98411.1 - 6.3e-06 25.5 3.5 1.5e-05 24.3 3.5 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Vpu PF00558.19 KOG98411.1 - 0.0044 16.8 0.0 0.014 15.1 0.0 1.9 1 0 0 1 1 1 1 Vpu protein Sir1 PF11603.8 KOG98412.1 - 3.3e-51 172.8 7.7 6e-25 88.1 0.3 3.8 4 0 0 4 4 4 3 Regulatory protein Sir1 DUF1908 PF08926.11 KOG98412.1 - 0.067 12.3 1.2 7.4 5.6 0.6 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF1908) PA14 PF07691.12 KOG98413.1 - 6e-34 117.0 0.0 1.2e-33 115.9 0.0 1.5 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 KOG98413.1 - 1.8e-22 79.6 0.4 1.8e-22 79.6 0.4 1.9 2 0 0 2 2 2 1 GLEYA domain EcoRI PF02963.16 KOG98413.1 - 0.025 13.6 0.0 0.037 13.0 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease EcoRI Acetyltransf_1 PF00583.25 KOG98414.1 - 2e-05 24.8 0.0 2.7e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOG98414.1 - 0.015 15.7 0.0 0.023 15.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 KOG98414.1 - 0.077 13.7 0.0 0.13 12.9 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Hyphal_reg_CWP PF11765.8 KOG98415.1 - 6.1e-20 71.4 11.1 6.1e-20 71.4 11.1 2.4 1 1 1 2 2 2 1 Hyphally regulated cell wall protein N-terminal Flocculin_t3 PF13928.6 KOG98415.1 - 0.00069 20.1 12.6 0.00069 20.1 12.6 7.7 3 2 3 6 6 6 3 Flocculin type 3 repeat Bacteriocin_II PF01721.18 KOG98415.1 - 0.027 14.6 13.2 2.9 8.1 0.4 4.1 3 0 0 3 3 3 0 Class II bacteriocin adh_short PF00106.25 KOG98416.1 - 5.3e-27 94.6 0.0 6.4e-27 94.3 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOG98416.1 - 1.1e-21 77.5 0.0 1.4e-21 77.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOG98416.1 - 2.6e-08 34.0 0.0 3.7e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 KOG98416.1 - 0.021 14.3 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOG98416.1 - 0.056 12.9 0.0 0.08 12.4 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KOG98416.1 - 0.19 11.6 0.0 0.25 11.2 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding DJ-1_PfpI PF01965.24 KOG98417.1 - 2e-08 34.2 0.0 1.5e-07 31.4 0.0 2.0 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 KOG98417.1 - 0.004 16.9 0.5 0.011 15.5 0.5 1.8 1 1 0 1 1 1 1 ThiJ/PfpI family-like PA14 PF07691.12 KOG98418.1 - 9.9e-25 87.1 0.2 2.2e-24 86.0 0.2 1.6 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 KOG98418.1 - 6.7e-20 71.3 0.1 6.7e-20 71.3 0.1 2.4 3 0 0 3 3 3 1 GLEYA domain Flocculin PF00624.18 KOG98418.1 - 5.4e-06 26.6 19.8 5.4e-06 26.6 19.8 4.7 3 1 0 3 3 3 1 Flocculin repeat OPT PF03169.15 KOG98419.1 - 7.5e-156 520.3 43.8 9e-156 520.1 43.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Pex2_Pex12 PF04757.14 KOG98420.1 - 7.4e-20 71.5 2.0 9.4e-20 71.2 2.0 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region GST_C PF00043.25 KOG98421.1 - 0.054 13.7 0.1 0.15 12.3 0.1 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF4525 PF15027.6 KOG98421.1 - 0.055 13.2 0.2 0.12 12.1 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) Endonuclease_NS PF01223.23 KOG98422.1 - 2e-68 230.6 0.0 2.5e-68 230.3 0.0 1.0 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Sec10 PF07393.11 KOG98424.1 - 1.2e-66 225.6 19.0 1.5e-66 225.3 19.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF1981 PF09324.10 KOG98424.1 - 0.022 14.6 2.0 0.11 12.4 0.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) F-box PF00646.33 KOG98424.1 - 0.043 13.7 0.1 0.27 11.2 0.0 2.3 2 0 0 2 2 2 0 F-box domain Telomere_reg-2 PF10193.9 KOG98424.1 - 0.14 12.6 2.0 0.4 11.1 2.0 1.8 1 0 0 1 1 1 0 Telomere length regulation protein Surp PF01805.20 KOG98425.1 - 1.5e-17 63.4 0.0 8.8e-09 35.2 0.1 2.7 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.8 KOG98425.1 - 4.9e-09 36.4 4.3 1.9e-08 34.4 4.3 1.9 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein GSCFA PF08885.11 KOG98425.1 - 0.036 13.7 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 GSCFA family CRAL_TRIO_2 PF13716.6 KOG98426.1 - 1.3e-29 103.1 0.8 2.7e-29 102.1 0.8 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 KOG98426.1 - 1.4e-07 31.5 0.2 5e-07 29.7 0.2 1.9 1 0 0 1 1 1 1 RhoGAP domain Aconitase PF00330.20 KOG98427.1 - 6.7e-150 500.1 0.0 1.1e-149 499.4 0.0 1.3 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KOG98427.1 - 1.6e-43 148.2 0.0 2.8e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 KOG98427.1 - 0.025 13.3 0.1 0.049 12.3 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF521) Endonuc-PvuII PF09225.10 KOG98427.1 - 0.13 12.0 0.1 7.1 6.4 0.0 3.0 3 0 0 3 3 3 0 Restriction endonuclease PvuII SPX PF03105.19 KOG98428.1 - 1.3e-42 147.1 12.7 9.2e-40 137.7 12.7 3.0 1 1 0 1 1 1 1 SPX domain CitMHS PF03600.16 KOG98428.1 - 3.9e-25 88.7 44.9 3.4e-17 62.6 23.8 2.2 1 1 1 2 2 2 2 Citrate transporter Na_sulph_symp PF00939.19 KOG98428.1 - 8.4e-20 71.2 34.1 1.2e-19 70.8 34.1 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region Exo5 PF09810.9 KOG98428.1 - 0.0064 16.0 1.6 0.011 15.3 1.6 1.3 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease DUF5470 PF17564.2 KOG98428.1 - 0.014 15.6 1.2 0.033 14.4 1.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5470) DUF5082 PF16888.5 KOG98428.1 - 0.064 13.5 0.7 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) UCH PF00443.29 KOG98429.1 - 1.5e-83 280.2 0.6 2.7e-83 279.4 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOG98429.1 - 1.3e-16 61.1 1.1 4e-07 29.9 0.2 3.2 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 KOG98429.1 - 0.00012 22.6 0.0 0.00072 20.1 0.0 2.4 1 0 0 1 1 1 1 DUSP domain Ribosomal_S17e PF00833.18 KOG98429.1 - 0.028 14.3 0.1 0.059 13.3 0.1 1.5 1 0 0 1 1 1 0 Ribosomal S17 E1_UFD PF09358.10 KOG98429.1 - 0.041 14.6 0.1 0.21 12.3 0.1 2.2 1 0 0 1 1 1 0 Ubiquitin fold domain ELO PF01151.18 KOG98430.1 - 1.9e-57 194.7 27.9 2.4e-57 194.3 27.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family AAA_22 PF13401.6 KOG98431.1 - 7.2e-12 45.8 0.0 2.1e-11 44.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 KOG98431.1 - 1.1e-09 38.7 0.0 4.9e-09 36.7 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Cdc6_C PF09079.11 KOG98431.1 - 4.3e-07 29.8 0.1 1.3e-06 28.2 0.1 1.9 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_16 PF13191.6 KOG98431.1 - 9.3e-07 29.4 0.0 7.4e-06 26.5 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 KOG98431.1 - 2.4e-05 23.9 0.0 0.26 10.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region TniB PF05621.11 KOG98431.1 - 0.00014 21.3 0.0 0.021 14.2 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein NACHT PF05729.12 KOG98431.1 - 0.0017 18.3 0.1 0.55 10.1 0.2 2.8 2 0 0 2 2 2 1 NACHT domain KAP_NTPase PF07693.14 KOG98431.1 - 0.0028 16.9 0.0 0.31 10.2 0.1 2.3 1 1 1 2 2 2 1 KAP family P-loop domain AAA_19 PF13245.6 KOG98431.1 - 0.0036 17.6 0.0 0.0088 16.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 KOG98431.1 - 0.015 14.6 0.0 0.052 12.8 0.0 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AFG1_ATPase PF03969.16 KOG98431.1 - 0.019 13.9 0.0 0.18 10.6 0.0 2.0 2 0 0 2 2 2 0 AFG1-like ATPase NB-ARC PF00931.22 KOG98431.1 - 0.026 13.7 0.0 0.36 10.0 0.0 2.6 2 1 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 KOG98431.1 - 0.054 13.4 0.0 0.26 11.2 0.0 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 KOG98431.1 - 0.064 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein TPT PF03151.16 KOG98432.1 - 1.2e-33 116.7 19.2 2e-17 63.5 2.1 2.5 2 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 KOG98432.1 - 0.038 14.2 39.2 0.6 10.3 15.2 4.7 3 2 1 4 4 4 0 EamA-like transporter family DUF1279 PF06916.13 KOG98432.1 - 3.1 8.4 7.0 11 6.6 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1279) SOP4 PF17081.5 KOG98433.1 - 1.1e-96 322.4 1.3 1.3e-96 322.2 1.3 1.0 1 0 0 1 1 1 1 Suppressor of PMA 1-7 protein DUF4538 PF15061.6 KOG98433.1 - 1 9.1 4.3 0.43 10.4 0.3 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4538) Ribosomal_S11 PF00411.19 KOG98434.1 - 9.5e-46 154.7 2.2 1.2e-45 154.4 2.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 BKACE PF05853.12 KOG98434.1 - 0.086 12.1 0.3 0.1 11.9 0.3 1.1 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme Ribosomal_S8 PF00410.19 KOG98435.1 - 3.4e-24 85.2 0.1 4.9e-24 84.7 0.1 1.2 1 1 0 1 1 1 1 Ribosomal protein S8 Ribosomal_L39 PF00832.20 KOG98436.1 - 8e-20 70.2 16.1 9.5e-20 70.0 16.1 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Pkinase PF00069.25 KOG98437.1 - 1.1e-48 165.9 0.3 1.8e-47 161.9 0.3 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98437.1 - 9.1e-27 94.0 0.1 1.5e-26 93.3 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4299 PF14132.6 KOG98437.1 - 0.00078 19.0 1.3 0.0018 17.8 1.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4299) U1snRNP70_N PF12220.8 KOG98437.1 - 0.45 11.2 10.5 2.4 8.9 4.8 2.8 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal CobT PF06213.12 KOG98437.1 - 2.7 7.3 9.9 5 6.4 9.9 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 KOG98437.1 - 9.6 4.2 16.6 22 3.0 16.6 1.5 1 0 0 1 1 1 0 DNA polymerase phi Mannosyl_trans3 PF11051.8 KOG98438.1 - 7.9e-81 271.4 0.1 1.2e-80 270.8 0.1 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Gon7 PF08738.10 KOG98440.1 - 5.7e-44 148.6 0.2 6.6e-44 148.4 0.2 1.0 1 0 0 1 1 1 1 Gon7 family FlxA PF14282.6 KOG98440.1 - 0.063 13.3 1.8 0.089 12.8 1.8 1.2 1 0 0 1 1 1 0 FlxA-like protein Glyco_transf_34 PF05637.12 KOG98441.1 - 5.9e-66 222.6 0.0 7.8e-66 222.2 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family ATP12 PF07542.11 KOG98443.1 - 4e-32 111.0 0.0 6.7e-32 110.3 0.0 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein Prefoldin_2 PF01920.20 KOG98444.1 - 6e-13 48.7 9.9 6.6e-13 48.5 9.9 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF948 PF06103.11 KOG98444.1 - 0.0092 16.2 2.0 2 8.7 0.2 2.1 2 0 0 2 2 2 2 Bacterial protein of unknown function (DUF948) ATG27 PF09451.10 KOG98445.1 - 1.2e-55 189.3 2.7 1.4e-55 189.0 2.7 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 KOG98445.1 - 0.0044 17.1 2.4 0.032 14.3 1.1 2.1 2 0 0 2 2 2 1 Cation-independent mannose-6-phosphate receptor repeat CrgA PF06781.12 KOG98445.1 - 0.0056 16.7 0.0 0.032 14.3 0.0 2.0 2 0 0 2 2 2 1 Cell division protein CrgA SARAF PF06682.12 KOG98445.1 - 0.053 13.2 0.0 0.08 12.6 0.0 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Ribosomal_L22 PF00237.19 KOG98446.1 - 6.9e-38 129.0 1.7 1.4e-37 128.0 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e SWIRM PF04433.17 KOG98447.1 - 5e-28 97.3 2.1 7.7e-28 96.7 0.1 2.3 2 0 0 2 2 2 1 SWIRM domain SWIRM-assoc_1 PF16495.5 KOG98447.1 - 1.4e-23 82.7 6.9 3.3e-23 81.4 6.9 1.7 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 KOG98447.1 - 4.1e-13 49.3 0.0 1.1e-12 47.9 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOG98447.1 - 1.6e-08 34.7 0.1 6.9e-08 32.6 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOG98447.1 - 0.28 11.1 0.0 0.28 11.1 0.0 3.6 3 0 0 3 3 3 0 Myb DNA-binding like KRE9 PF05390.11 KOG98448.1 - 3.7e-49 165.7 9.9 3.7e-49 165.7 9.9 2.4 2 1 0 3 3 3 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.9 KOG98448.1 - 3.6e-15 56.5 0.4 3.6e-15 56.5 0.4 2.6 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Rep_fac-A_3 PF08661.11 KOG98449.1 - 6.3e-32 110.1 0.0 7.1e-32 109.9 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Peptidase_M20 PF01546.28 KOG98450.1 - 5.4e-43 147.1 0.0 8.8e-43 146.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KOG98450.1 - 1.4e-19 70.0 0.0 2.4e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain DUF2401 PF10287.9 KOG98451.1 - 1.1e-84 283.6 2.2 1.5e-84 283.2 2.2 1.2 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 KOG98451.1 - 2.2e-23 82.5 0.0 6.4e-23 81.0 0.0 1.9 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) SRI PF08236.11 KOG98453.1 - 4.9e-23 81.1 6.0 4.9e-23 81.1 6.0 3.5 1 1 2 3 3 3 1 SRI (Set2 Rpb1 interacting) domain WW_1 PF18507.1 KOG98453.1 - 6.8e-18 64.0 2.8 2.2e-17 62.4 2.8 2.0 1 0 0 1 1 1 1 WW domain SET PF00856.28 KOG98453.1 - 3.1e-17 63.5 0.3 3.1e-17 63.5 0.3 4.6 3 2 0 3 3 3 1 SET domain AWS PF17907.1 KOG98453.1 - 2.1e-15 56.5 10.5 2.1e-15 56.5 10.5 2.3 3 0 0 3 3 3 1 AWS domain Med26 PF08711.11 KOG98453.1 - 0.039 14.0 0.0 0.039 14.0 0.0 3.5 3 1 0 3 3 3 0 TFIIS helical bundle-like domain WW PF00397.26 KOG98453.1 - 0.096 12.8 0.1 0.2 11.8 0.1 1.5 1 0 0 1 1 1 0 WW domain Antimicrobial_7 PF08102.11 KOG98453.1 - 1.7 9.0 4.7 37 4.7 0.9 3.2 2 0 0 2 2 2 0 Scorpion antimicrobial peptide polyprenyl_synt PF00348.17 KOG98454.1 - 5.4e-98 327.1 0.2 6.4e-98 326.9 0.2 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase UcrQ PF02939.16 KOG98455.1 - 6.4e-35 118.9 2.8 7.4e-35 118.7 2.8 1.0 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 KOG98455.1 - 0.00022 21.6 0.2 0.00029 21.1 0.2 1.3 1 0 0 1 1 1 1 Cytochrome b-c1 complex subunit 8 Pkinase PF00069.25 KOG98456.1 - 1.8e-39 135.7 0.1 3.5e-38 131.5 0.0 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98456.1 - 2.1e-18 66.6 0.0 6.1e-18 65.0 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG98456.1 - 0.024 13.9 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 KOG98456.1 - 0.068 12.5 0.1 0.16 11.3 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 KOG98457.1 - 1.3e-71 241.0 0.0 1.7e-71 240.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98457.1 - 1e-40 139.7 0.0 1.4e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG98457.1 - 1.9e-05 24.1 0.0 3.5e-05 23.3 0.0 1.4 1 1 0 1 1 1 1 Kinase-like DUF3297 PF11730.8 KOG98457.1 - 0.041 13.8 0.1 0.43 10.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3297) APH PF01636.23 KOG98457.1 - 0.045 13.7 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOG98457.1 - 0.066 12.1 0.0 0.092 11.7 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 KOG98457.1 - 0.067 12.2 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 FTA2 PF13095.6 KOG98457.1 - 0.073 12.7 0.0 2.9 7.5 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 MFS_1 PF07690.16 KOG98458.1 - 4e-20 72.1 18.1 4e-20 72.1 18.1 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3099 PF11298.8 KOG98458.1 - 0.08 13.1 0.1 0.08 13.1 0.1 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF3099) TMEM208_SND2 PF05620.11 KOG98458.1 - 1.2 8.9 8.0 2.1 8.1 0.3 2.9 3 1 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 DnaJ PF00226.31 KOG98459.1 - 5.2e-17 61.7 1.4 1.1e-16 60.7 0.2 2.3 2 0 0 2 2 2 1 DnaJ domain PIR PF00399.19 KOG98461.1 - 1.3e-21 75.5 29.3 5.5e-08 32.2 0.9 4.2 4 0 0 4 4 4 3 Yeast PIR protein repeat SIL1 PF16782.5 KOG98461.1 - 0.6 9.3 5.2 0.8 8.9 5.2 1.1 1 0 0 1 1 1 0 Nucleotide exchange factor SIL1 DUF5582 PF17819.1 KOG98461.1 - 1 9.8 11.4 4.3 7.8 0.1 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5582) PIR PF00399.19 KOG98462.1 - 1.1e-10 40.8 22.1 4.6e-07 29.2 7.0 3.0 2 0 0 2 2 2 2 Yeast PIR protein repeat TPP_enzyme_C PF02775.21 KOG98462.1 - 0.046 13.5 0.3 0.07 12.9 0.3 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PAP1 PF08601.10 KOG98462.1 - 0.63 9.7 9.8 0.75 9.5 9.8 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Prok-RING_1 PF14446.6 KOG98463.1 - 0.13 12.2 3.8 0.22 11.4 0.4 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-C3HC4 PF00097.25 KOG98463.1 - 0.56 10.1 5.6 1.6 8.7 5.6 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOG98463.1 - 0.66 9.8 7.5 0.18 11.5 2.4 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_5 PF14634.6 KOG98463.1 - 3.5 7.7 4.9 7.7 6.6 4.9 1.6 1 0 0 1 1 1 0 zinc-RING finger domain Peptidase_S64 PF08192.11 KOG98464.1 - 5.4e-270 897.8 0.5 6.1e-270 897.6 0.5 1.0 1 0 0 1 1 1 1 Peptidase family S64 6PF2K PF01591.18 KOG98465.1 - 5.5e-89 297.3 0.5 7.8e-89 296.8 0.5 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KOG98465.1 - 1.6e-39 135.6 0.0 2.3e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 KOG98465.1 - 0.0014 18.8 0.0 0.0027 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Vps35 PF03635.17 KOG98466.1 - 5.6e-270 897.9 38.8 6.9e-270 897.7 38.8 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 NAD_binding_5 PF07994.12 KOG98467.1 - 7.5e-146 485.6 0.0 8.8e-146 485.4 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 KOG98467.1 - 5e-44 149.0 0.3 1.1e-43 147.9 0.3 1.6 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Pmp3 PF01679.17 KOG98468.1 - 1.9e-16 60.0 5.1 2.4e-16 59.7 5.1 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator F-box-like PF12937.7 KOG98469.1 - 1.1e-09 38.0 0.1 3.5e-09 36.4 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOG98469.1 - 1.8e-06 27.7 0.1 7.8e-06 25.6 0.1 2.1 1 0 0 1 1 1 1 F-box domain RNA_polI_A34 PF08208.11 KOG98470.1 - 3.8e-25 89.2 16.9 3.8e-25 89.2 16.9 1.5 1 1 1 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 DUF3122 PF11320.8 KOG98470.1 - 0.035 14.2 0.1 0.069 13.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3122) Peptidase_S49_N PF08496.10 KOG98470.1 - 2.2 8.4 14.2 12 6.0 11.9 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal CRAL_TRIO PF00650.20 KOG98473.1 - 1.8e-24 86.3 0.1 6.6e-24 84.4 0.1 1.8 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KOG98473.1 - 0.00064 19.9 0.0 0.00064 19.9 0.0 2.5 4 0 0 4 4 4 1 CRAL/TRIO, N-terminal domain Tim17 PF02466.19 KOG98475.1 - 3.4e-31 107.9 6.1 4.4e-31 107.5 6.1 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Phage_holin_3_3 PF16083.5 KOG98475.1 - 0.029 14.5 7.7 0.14 12.3 1.4 2.5 2 1 0 2 2 2 0 LydA holin phage, holin superfamily III Pkinase PF00069.25 KOG98476.1 - 2.1e-48 165.0 0.1 2.1e-48 165.0 0.1 3.7 2 2 0 2 2 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98476.1 - 1.2e-19 70.6 0.0 1.2e-19 70.6 0.0 2.7 2 1 0 2 2 1 1 Protein tyrosine kinase Presenilin PF01080.17 KOG98476.1 - 0.0015 17.4 41.3 0.0015 17.4 41.3 2.0 2 0 0 2 2 2 1 Presenilin APH PF01636.23 KOG98476.1 - 0.0052 16.7 0.0 0.0052 16.7 0.0 2.3 2 0 0 2 2 1 1 Phosphotransferase enzyme family Mem_trans PF03547.18 KOG98476.1 - 0.011 14.2 1.7 0.016 13.7 1.7 1.2 1 0 0 1 1 1 0 Membrane transport protein Caldesmon PF02029.15 KOG98476.1 - 0.013 14.3 35.6 0.019 13.7 35.6 1.2 1 0 0 1 1 1 0 Caldesmon CDC45 PF02724.14 KOG98476.1 - 0.077 11.3 31.3 0.14 10.4 31.3 1.4 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 KOG98476.1 - 0.079 12.8 37.5 0.18 11.6 37.5 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nop14 PF04147.12 KOG98476.1 - 0.49 8.5 33.7 0.78 7.9 33.7 1.3 1 0 0 1 1 1 0 Nop14-like family CCSAP PF15748.5 KOG98476.1 - 0.52 10.5 52.8 0.037 14.2 47.5 1.8 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated PA26 PF04636.13 KOG98476.1 - 3.5 6.4 28.0 7.1 5.4 28.0 1.5 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Asp-B-Hydro_N PF05279.11 KOG98476.1 - 3.8 7.5 28.7 6.6 6.7 28.7 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region ALMT PF11744.8 KOG98476.1 - 5.9 5.6 30.5 15 4.3 30.5 1.7 1 0 0 1 1 1 0 Aluminium activated malate transporter AAA_11 PF13086.6 KOG98476.1 - 9.3 5.9 37.2 24 4.6 37.2 1.7 1 0 0 1 1 1 0 AAA domain RNA_pol_Rpb4 PF03874.16 KOG98477.1 - 5.7e-35 120.3 10.2 3.1e-34 118.0 10.2 2.1 1 1 0 1 1 1 1 RNA polymerase Rpb4 Rtf2 PF04641.12 KOG98477.1 - 0.028 13.8 5.9 0.037 13.4 5.9 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Cellulose_synt PF03552.14 KOG98477.1 - 0.029 12.9 1.7 0.034 12.6 1.7 1.1 1 0 0 1 1 1 0 Cellulose synthase GAGA_bind PF06217.12 KOG98477.1 - 0.2 11.9 4.7 0.27 11.5 4.7 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family FAM176 PF14851.6 KOG98477.1 - 1.2 8.8 7.8 0.086 12.5 3.1 1.6 2 0 0 2 2 2 0 FAM176 family FYDLN_acid PF09538.10 KOG98477.1 - 2.8 8.7 13.2 0.59 10.8 9.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) IncFII_repA PF02387.15 KOG98477.1 - 3.1 7.0 6.6 1.7 7.8 3.2 2.2 3 0 0 3 3 3 0 IncFII RepA protein family Glyco_transf_15 PF01793.16 KOG98478.1 - 1.1e-105 353.4 12.0 1.4e-105 353.1 12.0 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DEAD PF00270.29 KOG98479.1 - 3.3e-44 150.7 0.4 4.1e-44 150.4 0.4 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOG98479.1 - 3e-08 33.8 0.0 4.8e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 KOG98479.1 - 0.00037 20.3 0.1 0.00049 19.9 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOG98479.1 - 0.00089 19.6 0.1 0.0013 19.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain DUF1811 PF08838.10 KOG98479.1 - 0.1 12.9 0.0 21 5.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) PhoH PF02562.16 KOG98479.1 - 0.16 11.4 1.2 0.93 8.9 1.2 2.0 1 1 0 1 1 1 0 PhoH-like protein Glyco_transf_8 PF01501.20 KOG98480.1 - 2e-43 148.8 0.1 3.1e-43 148.2 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Bromo_TP_like PF17027.5 KOG98480.1 - 0.033 14.3 0.5 4.1 7.6 0.0 2.5 2 0 0 2 2 2 0 Histone-fold protein PAP2 PF01569.21 KOG98481.1 - 8.2e-16 58.0 3.0 8.2e-16 58.0 3.0 1.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 KOG98481.1 - 0.086 12.5 6.1 0.17 11.5 6.1 1.6 1 1 0 1 1 1 0 PAP2 superfamily Fer4_5 PF12801.7 KOG98481.1 - 2.1 8.3 9.5 0.36 10.8 3.9 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain 2TM PF13239.6 KOG98481.1 - 4.2 7.7 6.6 0.54 10.6 1.4 2.2 2 0 0 2 2 2 0 2TM domain Mito_carr PF00153.27 KOG98483.1 - 3.5e-62 206.4 2.9 1.4e-22 79.4 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein mIF3 PF14877.6 KOG98484.1 - 5.5e-65 218.3 9.3 5.5e-65 218.3 9.3 1.6 2 0 0 2 2 2 1 Mitochondrial translation initiation factor DUF2299 PF10061.9 KOG98484.1 - 0.042 13.6 1.1 1.1 9.0 0.1 3.2 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2299) CPSase_L_D2 PF02786.17 KOG98485.1 - 3.6e-115 382.8 1.2 5e-84 281.0 0.1 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 KOG98485.1 - 6e-49 165.1 0.0 1.6e-48 163.8 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 KOG98485.1 - 8.4e-46 156.1 0.0 1.9e-45 155.0 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 KOG98485.1 - 3.5e-45 153.7 0.3 1.7e-44 151.4 0.0 2.3 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 KOG98485.1 - 5.5e-40 136.5 0.3 1.8e-39 134.9 0.1 2.0 2 0 0 2 2 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 KOG98485.1 - 7.5e-30 104.1 0.1 7.2e-29 100.9 0.0 2.7 3 0 0 3 3 3 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 KOG98485.1 - 2.9e-21 75.5 0.0 1.5e-20 73.2 0.0 2.4 2 0 0 2 2 1 1 MGS-like domain Dala_Dala_lig_C PF07478.13 KOG98485.1 - 1.3e-18 67.3 3.5 8.9e-11 41.7 0.4 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KOG98485.1 - 5e-15 55.5 0.8 4.7e-07 29.5 0.1 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 KOG98485.1 - 6.5e-12 45.3 0.1 1.5e-06 28.0 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 KOG98485.1 - 8.4e-06 25.9 1.6 0.02 14.9 0.2 2.7 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.13 KOG98485.1 - 9.9e-05 22.2 0.0 0.0085 15.9 0.0 2.6 1 1 0 1 1 1 1 Peptidase C26 RimK PF08443.11 KOG98485.1 - 0.00014 21.5 0.1 0.061 12.9 0.1 2.9 3 0 0 3 3 3 1 RimK-like ATP-grasp domain GARS_A PF01071.19 KOG98485.1 - 0.0057 16.5 0.6 3.3 7.4 0.0 3.0 3 1 0 3 3 3 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DJ-1_PfpI PF01965.24 KOG98485.1 - 0.014 15.2 0.5 2.2 8.0 0.0 4.2 5 0 0 5 5 5 0 DJ-1/PfpI family ATP-grasp_5 PF13549.6 KOG98485.1 - 0.058 12.8 0.3 11 5.4 0.0 2.5 2 0 0 2 2 2 0 ATP-grasp domain NBD_C PF17042.5 KOG98485.1 - 0.19 12.2 0.7 32 5.0 0.0 3.4 4 0 0 4 4 3 0 Nucleotide-binding C-terminal domain TrkA_N PF02254.18 KOG98485.1 - 0.23 11.7 2.6 0.68 10.2 0.1 2.9 3 0 0 3 3 2 0 TrkA-N domain TrkH PF02386.16 KOG98486.1 - 2.4e-206 686.0 0.0 1.3e-202 673.7 0.0 2.2 2 0 0 2 2 2 2 Cation transport protein Vps54 PF07928.12 KOG98486.1 - 0.063 13.7 0.1 0.15 12.5 0.1 1.5 1 0 0 1 1 1 0 Vps54-like protein Pkinase PF00069.25 KOG98487.1 - 7.7e-60 202.5 0.0 1.1e-59 202.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98487.1 - 4.9e-36 124.3 0.0 7.3e-36 123.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG98487.1 - 0.00012 21.5 0.0 0.0002 20.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 KOG98487.1 - 0.00036 19.7 0.2 0.0013 17.9 0.1 1.8 2 0 0 2 2 2 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 KOG98487.1 - 0.014 14.2 2.5 0.016 14.0 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase Hep_59 PF07052.11 KOG98487.1 - 4 8.3 5.4 6.6 7.5 0.0 2.9 2 1 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 DUF5310 PF17237.2 KOG98488.1 - 1.1e-22 79.6 1.6 1.3e-22 79.4 1.6 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5310) zf-H2C2 PF09337.10 KOG98489.1 - 9.9e-17 60.9 1.5 1.8e-16 60.0 1.5 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 KOG98489.1 - 9.4e-10 38.5 0.8 2.6e-09 37.0 0.8 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 KOG98489.1 - 2.9e-05 24.3 0.0 8.8e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family DUF5392 PF17370.2 KOG98489.1 - 0.023 14.8 0.2 0.042 13.9 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5392) CN_hydrolase PF00795.22 KOG98490.1 - 1.7e-56 191.5 0.0 1.9e-56 191.3 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase PM0188 PF11477.8 KOG98490.1 - 0.069 12.3 0.8 0.095 11.9 0.8 1.1 1 0 0 1 1 1 0 Sialyltransferase PMO188 GCD14 PF08704.10 KOG98491.1 - 8e-82 274.6 0.3 6e-81 271.7 0.3 2.1 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit RrnaAD PF00398.20 KOG98491.1 - 0.001 18.2 0.0 0.0023 17.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Gcd10p PF04189.13 KOG98491.1 - 0.0021 17.3 0.3 0.0088 15.2 0.0 1.9 2 0 0 2 2 2 1 Gcd10p family GCD14_N PF14801.6 KOG98491.1 - 0.0029 17.4 0.0 0.0076 16.1 0.0 1.7 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_31 PF13847.6 KOG98491.1 - 0.0046 16.8 0.0 0.012 15.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOG98491.1 - 0.0079 16.0 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 KOG98491.1 - 0.015 16.0 0.0 0.036 14.8 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain LSM PF01423.22 KOG98492.1 - 3.1e-16 58.8 0.1 5.4e-16 58.0 0.1 1.4 1 0 0 1 1 1 1 LSM domain Alb1 PF09135.11 KOG98493.1 - 5.1e-18 65.9 5.6 5.1e-18 65.9 5.6 1.9 2 0 0 2 2 2 1 Alb1 NUDE_C PF04880.13 KOG98493.1 - 0.013 16.0 3.3 0.017 15.6 3.3 1.2 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Paramyxo_C PF01692.18 KOG98493.1 - 0.064 12.6 3.1 1.2 8.5 0.4 2.1 1 1 1 2 2 2 0 Paramyxovirus non-structural protein C Ribul_P_3_epim PF00834.19 KOG98494.1 - 3.6e-68 228.9 0.0 7.8e-68 227.8 0.0 1.5 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 KOG98494.1 - 0.042 13.6 0.0 0.14 12.0 0.0 1.8 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain OMPdecase PF00215.24 KOG98494.1 - 0.058 13.0 0.0 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Pho86 PF11124.8 KOG98495.1 - 5.9e-104 347.6 0.3 6.7e-104 347.4 0.3 1.0 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 SUN PF03856.13 KOG98496.1 - 3.6e-99 331.2 14.1 4.4e-99 330.9 14.1 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) ASF1_hist_chap PF04729.13 KOG98497.1 - 4.4e-70 234.6 0.0 6.3e-70 234.1 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone Nop14 PF04147.12 KOG98497.1 - 0.12 10.6 40.3 0.15 10.3 40.3 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 KOG98497.1 - 0.42 9.9 38.0 0.48 9.7 38.0 1.1 1 0 0 1 1 1 0 BUD22 TFIIF_alpha PF05793.12 KOG98497.1 - 4.4 5.8 41.6 5.1 5.6 41.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SAPS PF04499.15 KOG98497.1 - 4.6 5.9 13.9 6.1 5.5 13.9 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein rve PF00665.26 KOG98498.1 - 1.5e-18 67.1 0.1 3.6e-18 65.9 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 KOG98498.1 - 0.0026 17.6 0.1 0.0082 16.0 0.1 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain CCDC53 PF10152.9 KOG98498.1 - 0.003 18.0 2.7 0.091 13.2 0.1 3.1 3 0 0 3 3 3 1 Subunit CCDC53 of WASH complex Rpr2 PF04032.16 KOG98498.1 - 0.59 10.5 4.2 0.49 10.7 0.5 2.8 3 0 0 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF724 PF05266.14 KOG98498.1 - 3.2 7.5 9.1 1 9.2 5.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) WD40 PF00400.32 KOG98499.1 - 3e-34 116.5 9.6 1.4e-07 32.0 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat Mdv1 PF11542.8 KOG98499.1 - 2.6e-25 88.1 0.8 5.3e-25 87.1 0.8 1.5 1 0 0 1 1 1 1 Mitochondrial division protein 1 Nup160 PF11715.8 KOG98499.1 - 1.9e-10 40.1 10.0 9.8e-05 21.2 0.4 5.3 1 1 4 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 KOG98499.1 - 4.9e-08 33.2 0.0 0.024 14.9 0.0 4.6 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain DUF16 PF01519.16 KOG98499.1 - 0.043 14.3 1.0 0.14 12.7 1.0 1.9 1 0 0 1 1 1 0 Protein of unknown function DUF16 APG6_N PF17675.1 KOG98499.1 - 0.08 13.5 6.7 0.2 12.2 6.7 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF1664 PF07889.12 KOG98499.1 - 0.19 11.8 1.8 0.52 10.4 1.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Sigma70_r1_1 PF03979.14 KOG98499.1 - 0.56 10.3 7.8 0.34 11.0 4.3 2.4 2 1 1 3 3 3 0 Sigma-70 factor, region 1.1 DUF2730 PF10805.8 KOG98499.1 - 1.4 9.0 4.5 0.65 10.1 1.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Jnk-SapK_ap_N PF09744.9 KOG98499.1 - 3.5 7.8 8.3 8.6 6.6 7.2 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Cpn60_TCP1 PF00118.24 KOG98500.1 - 1.5e-156 521.9 3.4 1.7e-156 521.7 3.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family GATA PF00320.27 KOG98501.1 - 3.7e-14 52.0 2.7 6.6e-14 51.2 2.7 1.4 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 KOG98501.1 - 0.0074 15.8 0.3 0.015 14.8 0.3 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding DUF812 PF05667.11 KOG98501.1 - 0.19 10.5 0.0 0.19 10.5 0.0 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF812) ArfGap PF01412.18 KOG98501.1 - 0.46 10.6 3.0 0.36 10.9 0.3 2.1 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf BP28CT PF08146.12 KOG98502.1 - 7.7e-36 123.3 1.6 7.7e-36 123.3 1.6 4.6 4 0 0 4 4 4 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 KOG98502.1 - 3e-20 72.7 2.4 3e-20 72.7 2.4 5.8 6 0 0 6 6 6 1 U3 small nucleolar RNA-associated protein 10 HEAT_2 PF13646.6 KOG98502.1 - 0.00011 22.6 1.3 3.7 8.0 0.0 6.1 6 0 0 6 6 6 1 HEAT repeats HEAT PF02985.22 KOG98502.1 - 0.0064 16.7 0.3 29 5.3 0.1 5.4 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.6 KOG98502.1 - 0.019 15.5 2.4 5.6 7.6 0.4 4.3 4 0 0 4 4 4 0 HEAT-like repeat IFT20 PF14931.6 KOG98502.1 - 0.19 11.9 0.1 0.19 11.9 0.1 4.1 5 0 0 5 5 5 0 Intraflagellar transport complex B, subunit 20 UNC45-central PF11701.8 KOG98502.1 - 0.67 9.9 8.4 4.2 7.3 0.0 4.7 3 1 0 3 3 3 0 Myosin-binding striated muscle assembly central ThrE PF06738.12 KOG98503.1 - 8.3e-71 238.2 17.7 4.5e-67 225.9 5.1 2.3 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 KOG98503.1 - 3.9e-10 40.0 9.4 3.9e-10 40.0 9.4 2.3 2 0 0 2 2 2 1 Threonine/Serine exporter, ThrE Pneumo_att_G PF05539.11 KOG98503.1 - 3.1 7.3 6.8 5.3 6.5 6.8 1.3 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Pkinase PF00069.25 KOG98504.1 - 1.4e-54 185.2 0.2 1.1e-52 179.1 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98504.1 - 1.6e-27 96.4 0.9 1.4e-25 90.1 0.2 2.8 2 1 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 KOG98504.1 - 4.6e-06 25.9 0.1 4.6e-06 25.9 0.1 2.0 2 0 0 2 2 2 1 Poxvirus serine/threonine protein kinase Kdo PF06293.14 KOG98504.1 - 0.073 12.4 0.2 0.16 11.3 0.2 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PHD PF00628.29 KOG98505.1 - 1.2e-09 37.9 9.3 1.2e-09 37.9 9.3 2.6 3 0 0 3 3 3 1 PHD-finger SET PF00856.28 KOG98505.1 - 1.2e-06 29.0 0.0 2.9e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 SET domain PHD_2 PF13831.6 KOG98505.1 - 3.4e-05 23.3 2.4 6.8e-05 22.3 2.4 1.5 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 KOG98505.1 - 0.028 14.3 1.7 0.028 14.3 1.7 2.8 4 0 0 4 4 4 0 Prokaryotic RING finger family 1 zf-UDP PF14569.6 KOG98505.1 - 0.19 11.8 3.6 0.47 10.6 3.6 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger Pam16 PF03656.13 KOG98506.1 - 1.2e-58 196.7 1.0 1.3e-58 196.5 1.0 1.0 1 0 0 1 1 1 1 Pam16 STb_secrete PF09075.10 KOG98506.1 - 0.08 13.0 0.6 0.26 11.4 0.1 2.0 1 1 1 2 2 2 0 Heat-stable enterotoxin B, secretory Zn_clus PF00172.18 KOG98507.1 - 3.1e-07 30.4 13.4 5.9e-07 29.5 13.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 KOG98507.1 - 0.005 16.8 0.0 0.02 14.9 0.0 2.0 2 0 0 2 2 2 1 PAS fold GTP_EFTU PF00009.27 KOG98508.1 - 4.5e-60 202.5 0.0 1e-59 201.4 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 KOG98508.1 - 1.2e-26 92.6 0.1 2.8e-26 91.4 0.1 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 KOG98508.1 - 1.1e-16 60.7 0.0 6.4e-10 38.9 0.0 2.5 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOG98508.1 - 4.4e-11 43.0 0.1 1.4e-10 41.4 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 KOG98508.1 - 3.4e-05 23.7 0.0 6.9e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 KOG98508.1 - 0.0065 16.5 0.2 0.02 14.9 0.1 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase GCS PF03074.16 KOG98509.1 - 2.3e-156 520.8 0.0 3e-156 520.4 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase PI3_PI4_kinase PF00454.27 KOG98510.1 - 5.9e-71 239.2 0.0 1e-70 238.5 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase ChAPs PF09295.10 KOG98511.1 - 1.8e-52 178.7 1.1 3.8e-42 144.7 0.4 2.2 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) ANAPC3 PF12895.7 KOG98511.1 - 2.8e-06 27.4 0.2 1.1e-05 25.6 0.1 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 KOG98511.1 - 7.6e-05 22.5 0.3 0.12 12.5 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOG98511.1 - 0.0049 16.6 0.6 0.038 13.8 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOG98511.1 - 0.04 14.1 0.1 0.12 12.6 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOG98511.1 - 0.052 14.2 0.0 0.1 13.2 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOG98511.1 - 0.075 13.6 0.3 0.23 12.0 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat SAPS PF04499.15 KOG98512.1 - 1.1e-175 585.2 11.2 1.1e-175 585.2 11.2 3.3 3 1 0 3 3 3 1 SIT4 phosphatase-associated protein PTPLA PF04387.14 KOG98513.1 - 5.2e-48 162.9 9.7 8.1e-48 162.3 9.7 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Ribosomal_L21p PF00829.21 KOG98514.1 - 6e-11 42.5 0.2 7.6e-11 42.2 0.2 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Pkinase PF00069.25 KOG98515.1 - 1.2e-66 224.8 0.1 1.2e-65 221.5 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98515.1 - 1.3e-45 155.8 0.0 2.3e-45 154.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG98515.1 - 1.8e-11 43.9 0.0 9.5e-08 31.7 0.0 2.7 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 KOG98515.1 - 0.26 11.2 0.0 0.42 10.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Na_H_Exchanger PF00999.21 KOG98516.1 - 2.7e-54 184.4 39.1 3.7e-54 184.0 39.1 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Ion_trans_2 PF07885.16 KOG98517.1 - 1.4e-27 95.5 24.1 2.9e-18 65.6 7.1 3.2 4 0 0 4 4 4 2 Ion channel Alba PF01918.21 KOG98517.1 - 0.16 11.8 0.3 0.61 10.0 0.0 2.1 2 0 0 2 2 2 0 Alba DUF21 PF01595.20 KOG98517.1 - 0.63 9.7 6.5 1.5 8.5 3.0 2.7 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain Ion_trans PF00520.31 KOG98517.1 - 1.3 8.2 33.0 6.8 5.8 6.6 4.1 3 2 0 3 3 3 0 Ion transport protein UvrD-helicase PF00580.21 KOG98518.1 - 1.1e-70 238.6 0.1 1.1e-70 238.6 0.1 2.9 3 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 KOG98518.1 - 1.8e-43 149.3 3.8 6e-43 147.5 1.9 2.6 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 KOG98518.1 - 1.3e-30 106.6 0.2 4.4e-30 104.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 KOG98518.1 - 3.3e-08 33.2 0.6 0.00026 20.8 0.0 2.9 3 0 0 3 3 3 2 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 KOG98518.1 - 8.1e-06 25.7 0.3 4.9e-05 23.1 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.6 KOG98518.1 - 4.9e-05 23.2 0.0 4.9e-05 23.2 0.0 3.5 3 1 0 3 3 3 1 AAA domain Helicase_RecD PF05127.14 KOG98518.1 - 0.0024 17.7 0.0 0.0089 15.9 0.0 2.0 2 0 0 2 2 2 1 Helicase DEAD PF00270.29 KOG98518.1 - 0.034 13.9 0.9 0.35 10.6 0.0 3.0 4 0 0 4 4 4 0 DEAD/DEAH box helicase GWT1 PF06423.12 KOG98519.1 - 6.7e-39 133.4 2.3 6.7e-39 133.4 2.3 2.7 3 1 1 4 4 4 1 GWT1 DUF4818 PF16089.5 KOG98519.1 - 0.12 12.8 0.0 0.12 12.8 0.0 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4818) BRCT PF00533.26 KOG98520.1 - 6e-27 93.9 7.0 1.1e-11 44.9 0.1 4.7 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KOG98520.1 - 1.5e-18 67.0 4.4 5.9e-08 33.0 0.0 4.1 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 KOG98520.1 - 2.2e-09 37.1 0.3 5.3e-06 26.3 0.0 4.3 5 0 0 5 5 5 1 twin BRCT domain Zn_clus PF00172.18 KOG98521.1 - 1e-10 41.5 10.8 1.6e-10 40.9 10.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAM180 PF15173.6 KOG98521.1 - 0.025 14.6 0.1 0.079 12.9 0.1 1.8 1 0 0 1 1 1 0 FAM180 family Phage_Treg PF04761.12 KOG98521.1 - 0.27 11.4 4.2 0.099 12.8 0.6 2.2 2 0 0 2 2 2 0 Lactococcus bacteriophage putative transcription regulator OTCace PF00185.24 KOG98522.1 - 1.2e-46 158.6 0.1 2.1e-46 157.9 0.1 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 KOG98522.1 - 3.1e-41 140.8 0.1 5.3e-41 140.1 0.1 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain RNA_lig_T4_1 PF09511.10 KOG98523.1 - 1.1e-79 267.3 0.1 2.8e-79 266.0 0.1 1.7 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.11 KOG98523.1 - 1.1e-75 253.4 0.8 1.1e-75 253.4 0.8 2.4 3 0 0 3 3 3 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.11 KOG98523.1 - 6.9e-63 212.5 1.7 9.5e-63 212.0 1.7 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain ABC_tran PF00005.27 KOG98523.1 - 0.06 13.9 0.1 0.15 12.6 0.1 1.7 1 0 0 1 1 1 0 ABC transporter YlbD_coat PF14071.6 KOG98523.1 - 2.9 8.2 7.7 0.88 9.8 0.2 3.0 1 1 0 2 2 2 0 Putative coat protein Exo70 PF03081.15 KOG98524.1 - 7e-85 285.3 11.1 7e-85 285.3 11.1 2.2 2 0 0 2 2 2 2 Exo70 exocyst complex subunit FEZ PF07763.13 KOG98524.1 - 0.18 11.5 5.3 0.038 13.7 0.8 2.1 3 0 0 3 3 3 0 FEZ-like protein Casc1_N PF15927.5 KOG98524.1 - 0.27 10.9 2.9 9.8 5.8 0.5 2.8 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus EF-hand_4 PF12763.7 KOG98525.1 - 0.0011 18.9 0.1 0.0026 17.7 0.1 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand DUF3808 PF10300.9 KOG98526.1 - 9.9e-165 548.9 0.2 1.2e-164 548.6 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_16 PF13432.6 KOG98526.1 - 0.15 12.7 5.2 18 6.1 0.3 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Actin PF00022.19 KOG98527.1 - 4.3e-99 331.9 0.0 5.4e-98 328.3 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 KOG98527.1 - 0.035 12.9 0.0 2.7 6.7 0.0 2.2 2 0 0 2 2 2 0 MreB/Mbl protein KH_1 PF00013.29 KOG98528.1 - 1.5e-89 293.8 34.7 7.8e-15 54.5 0.4 12.7 12 0 0 12 12 12 9 KH domain KH_2 PF07650.17 KOG98528.1 - 1e-12 47.7 18.6 0.001 18.8 0.0 7.1 5 2 0 6 6 6 4 KH domain KH_4 PF13083.6 KOG98528.1 - 2.5e-07 30.5 6.7 0.31 10.9 0.0 6.7 5 1 0 5 5 5 3 KH domain KH_5 PF13184.6 KOG98528.1 - 1.7e-06 28.0 16.3 0.23 11.6 0.1 7.0 6 0 0 6 6 6 3 NusA-like KH domain SLS PF14611.6 KOG98528.1 - 3.3e-05 23.8 18.7 0.003 17.4 0.0 6.7 4 3 3 7 7 7 2 Mitochondrial inner-membrane-bound regulator EMP24_GP25L PF01105.24 KOG98528.1 - 0.026 14.5 0.5 0.58 10.1 0.0 3.3 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DegQ PF08181.11 KOG98528.1 - 0.062 13.4 0.8 0.37 10.9 0.1 2.7 2 0 0 2 2 2 0 DegQ (SacQ) family DUF948 PF06103.11 KOG98528.1 - 0.084 13.1 3.3 40 4.6 0.0 4.1 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Skp1 PF01466.19 KOG98528.1 - 6.4 7.0 7.6 3.7 7.7 0.0 3.3 3 0 0 3 3 3 0 Skp1 family, dimerisation domain CAP PF00188.26 KOG98529.1 - 1.6e-18 67.7 0.9 1.6e-18 67.7 0.9 2.2 2 1 0 2 2 2 1 Cysteine-rich secretory protein family DUF3306 PF11748.8 KOG98529.1 - 0.001 19.9 5.6 0.002 19.0 5.6 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3306) Ndc1_Nup PF09531.10 KOG98529.1 - 0.034 12.9 6.1 0.042 12.6 6.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hamartin PF04388.12 KOG98529.1 - 2.3 6.8 12.3 2.6 6.6 12.3 1.0 1 0 0 1 1 1 0 Hamartin protein CAP PF00188.26 KOG98530.1 - 1.2e-17 65.0 3.1 1.2e-17 65.0 3.1 4.8 5 1 1 6 6 6 1 Cysteine-rich secretory protein family Cytokin_check_N PF10407.9 KOG98531.1 - 2.4e-31 107.5 3.4 5.3e-31 106.4 3.4 1.6 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus SMC_N PF02463.19 KOG98532.1 - 4.1e-49 167.0 71.6 3e-48 164.1 71.6 2.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KOG98532.1 - 4.2e-28 98.0 0.1 1.9e-27 95.9 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 KOG98532.1 - 2e-16 60.7 12.0 2.2e-10 40.9 0.3 4.0 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KOG98532.1 - 2e-11 44.2 19.9 2e-11 44.2 19.9 4.8 2 2 2 4 4 4 2 AAA ATPase domain AAA_29 PF13555.6 KOG98532.1 - 0.0064 16.2 0.0 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain BLOC1_2 PF10046.9 KOG98532.1 - 0.017 15.4 1.9 0.017 15.4 1.9 9.7 8 4 2 10 10 10 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_23 PF13476.6 KOG98532.1 - 0.054 14.0 136.6 0.086 13.3 60.5 7.7 3 2 2 5 5 5 0 AAA domain YozD PF14162.6 KOG98532.1 - 0.064 13.6 0.1 13 6.1 0.0 2.9 2 0 0 2 2 2 0 YozD-like protein DnaJ PF00226.31 KOG98533.1 - 2.4e-21 75.6 4.3 5.6e-21 74.4 4.3 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_8 PF13181.6 KOG98533.1 - 0.096 13.0 0.1 1.6 9.1 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5409 PF17421.2 KOG98533.1 - 3.4 8.4 6.0 3.6 8.4 0.0 3.7 2 1 2 4 4 4 0 Family of unknown function (DUF5409) Syntaxin-6_N PF09177.11 KOG98533.1 - 9.1 6.9 9.2 2.5 8.7 0.1 3.9 3 1 0 4 4 4 0 Syntaxin 6, N-terminal Sld5 PF05916.11 KOG98534.1 - 2.2e-18 66.7 1.7 4.6e-18 65.7 1.7 1.5 1 0 0 1 1 1 1 GINS complex protein NAT PF04768.13 KOG98535.1 - 2.3e-52 177.1 0.4 1.3e-51 174.7 0.1 2.2 3 0 0 3 3 3 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase A_deaminase PF00962.22 KOG98536.1 - 1.6e-24 86.8 0.0 2.9e-13 49.9 0.1 3.9 2 2 1 3 3 3 3 Adenosine/AMP deaminase WD40 PF00400.32 KOG98537.1 - 6.8e-15 55.2 0.1 5.7e-05 23.8 0.0 5.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG98537.1 - 2.1e-09 37.6 0.0 0.018 15.3 0.0 4.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Integrase_DNA PF02920.15 KOG98537.1 - 0.12 12.1 0.1 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 DNA binding domain of tn916 integrase Esterase PF00756.20 KOG98538.1 - 2e-70 237.3 0.3 2.2e-70 237.2 0.3 1.0 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 KOG98538.1 - 0.0087 15.3 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KOG98538.1 - 0.0088 15.5 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 KOG98538.1 - 0.017 15.8 0.1 0.034 14.7 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Esterase_phd PF10503.9 KOG98538.1 - 0.1 12.1 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase MPM1 PF17234.2 KOG98539.1 - 3.4e-38 131.6 0.0 4.6e-38 131.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial peculiar membrane protein 1 CBFD_NFYB_HMF PF00808.23 KOG98540.1 - 0.00017 21.8 0.0 0.00041 20.6 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Mrpl_C PF18502.1 KOG98541.1 - 5.6e-32 110.3 0.2 1.2e-31 109.3 0.2 1.5 1 0 0 1 1 1 1 54S ribosomal protein L8 C-terminal domain Ribosomal_L17 PF01196.19 KOG98541.1 - 8.6e-30 103.5 0.1 4.3e-29 101.3 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L17 Phosphodiest PF01663.22 KOG98543.1 - 3.4e-11 43.3 6.1 1.1e-08 35.1 6.1 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KOG98543.1 - 4.2e-05 23.1 0.0 8.6e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 KOG98543.1 - 0.017 14.5 0.1 0.028 13.8 0.1 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily LepA_C PF06421.12 KOG98544.1 - 0.01 16.0 2.8 0.027 14.6 2.8 1.7 1 0 0 1 1 1 0 GTP-binding protein LepA C-terminus Aminotran_1_2 PF00155.21 KOG98545.1 - 2.4e-90 303.3 0.0 2.8e-90 303.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 KOG98545.1 - 5e-06 26.1 0.0 9.7e-06 25.1 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 KOG98545.1 - 0.00073 18.2 0.2 0.0035 15.9 0.2 1.9 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KOG98545.1 - 0.0052 15.8 0.2 0.03 13.3 0.2 1.9 1 1 0 1 1 1 1 Aminotransferase class-V Aminotran_3 PF00202.21 KOG98545.1 - 0.0069 15.1 0.0 0.011 14.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III DUF2240 PF09999.9 KOG98545.1 - 0.089 12.4 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2240) CLN3 PF02487.17 KOG98546.1 - 1.1e-145 485.7 15.0 1.3e-145 485.4 15.0 1.1 1 0 0 1 1 1 1 CLN3 protein MFS_1 PF07690.16 KOG98546.1 - 1.1e-05 24.5 20.6 0.00011 21.2 20.6 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily Pex24p PF06398.11 KOG98546.1 - 0.28 10.1 2.7 0.83 8.6 2.7 1.8 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin HbrB PF08539.11 KOG98547.1 - 1.2e-32 113.3 0.1 4e-32 111.5 0.1 2.0 1 1 0 1 1 1 1 HbrB-like AbiJ_NTD4 PF18863.1 KOG98547.1 - 0.1 13.0 2.6 0.32 11.4 1.7 2.2 2 0 0 2 2 2 0 AbiJ N-terminal domain 4 Pkinase PF00069.25 KOG98548.1 - 2.4e-30 105.8 0.0 1.6e-29 103.1 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98548.1 - 2.6e-17 63.0 0.0 2.3e-16 59.9 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOG98548.1 - 0.0033 16.3 0.0 0.0052 15.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOG98548.1 - 0.027 13.8 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KOG98548.1 - 0.05 13.2 0.0 0.34 10.5 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 zf-C2H2 PF00096.26 KOG98549.1 - 8.4e-21 73.2 77.5 1.4e-05 25.2 1.0 10.9 11 0 0 11 11 11 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOG98549.1 - 6.9e-15 54.7 72.8 1.3e-07 31.7 0.3 8.8 10 0 0 10 10 8 4 Zinc-finger double domain Zap1_zf2 PF18217.1 KOG98549.1 - 8.8e-12 44.8 9.9 8.8e-12 44.8 9.9 5.2 5 0 0 5 5 5 1 Zap1 zinc finger 2 zf-C2H2_4 PF13894.6 KOG98549.1 - 9e-12 44.8 71.5 0.00017 22.1 0.9 10.4 10 0 0 10 10 10 7 C2H2-type zinc finger FOXP-CC PF16159.5 KOG98549.1 - 1.3e-07 32.1 34.2 0.00013 22.5 0.9 6.8 4 1 1 5 5 5 3 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 KOG98549.1 - 2.6e-06 27.6 5.6 2.6e-06 27.6 5.6 4.3 2 1 2 4 4 4 2 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 KOG98549.1 - 0.0032 17.4 51.7 0.11 12.5 1.8 7.6 6 1 1 7 7 6 5 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KOG98549.1 - 0.012 15.4 0.9 0.012 15.4 0.9 5.2 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 KOG98549.1 - 0.02 15.2 2.0 0.02 15.2 2.0 7.9 9 0 0 9 9 8 0 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 KOG98549.1 - 0.035 14.0 15.1 0.14 12.1 0.2 5.4 5 0 0 5 5 5 0 zinc-finger of a C2HC-type zf-met PF12874.7 KOG98549.1 - 0.92 10.0 50.3 0.2 12.1 3.2 8.1 9 0 0 9 9 9 0 Zinc-finger of C2H2 type zf_UBZ PF18439.1 KOG98549.1 - 5.3 6.7 18.8 2.2 7.9 0.1 5.6 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger Lysine_decarbox PF03641.14 KOG98550.1 - 1.3e-46 157.9 0.2 1.7e-46 157.6 0.2 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 KOG98550.1 - 7.3e-10 38.6 0.0 1.1e-09 38.0 0.0 1.4 1 1 0 1 1 1 1 SLOG cluster4 family Tim54 PF11711.8 KOG98551.1 - 8.3e-127 423.0 0.0 9.8e-127 422.8 0.0 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Vps26 PF03643.15 KOG98552.1 - 4.2e-123 409.7 0.0 4.9e-123 409.5 0.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 KOG98552.1 - 0.00015 21.8 0.3 0.00074 19.6 0.2 2.0 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 KOG98552.1 - 0.0032 17.9 0.4 0.01 16.3 0.1 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Gp_dh_C PF02800.20 KOG98553.1 - 3.9e-71 237.8 0.0 5.6e-71 237.2 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 KOG98553.1 - 8e-39 132.1 0.0 1.9e-38 130.9 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 KOG98553.1 - 0.0021 18.2 0.3 0.0068 16.5 0.1 2.2 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus TssN PF17555.2 KOG98554.1 - 0.65 9.3 4.7 1.1 8.6 4.7 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssN rRNA_proc-arch PF13234.6 KOG98555.1 - 7e-83 278.7 0.8 7e-83 278.7 0.8 2.2 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 KOG98555.1 - 3.9e-54 182.7 1.1 8.9e-54 181.6 1.1 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 KOG98555.1 - 1.7e-19 70.3 0.0 2.6e-17 63.2 0.0 3.0 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG98555.1 - 3.3e-06 27.4 0.0 3.1e-05 24.3 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG98555.1 - 0.00081 19.4 0.4 0.0047 16.9 0.0 2.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOG98555.1 - 0.048 13.9 0.0 0.18 12.1 0.0 2.1 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 KOG98555.1 - 0.073 12.1 0.1 0.19 10.8 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein Snf7 PF03357.21 KOG98556.1 - 8.7e-11 41.7 14.3 1.7e-10 40.7 14.3 1.5 1 0 0 1 1 1 1 Snf7 preATP-grasp_3 PF18301.1 KOG98556.1 - 0.062 13.6 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 pre ATP-grasp 3 domain RFC1 PF08519.12 KOG98556.1 - 0.067 13.4 1.0 0.22 11.7 1.0 1.9 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain Fib_alpha PF08702.10 KOG98556.1 - 0.091 12.9 0.2 0.091 12.9 0.2 3.4 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family Val_tRNA-synt_C PF10458.9 KOG98556.1 - 0.31 11.4 0.1 0.31 11.4 0.1 3.3 3 0 0 3 3 3 0 Valyl tRNA synthetase tRNA binding arm ABC_tran_CTD PF16326.5 KOG98556.1 - 0.38 11.0 10.6 0.35 11.1 0.1 3.0 2 1 0 2 2 2 0 ABC transporter C-terminal domain DUF5344 PF17279.2 KOG98556.1 - 5.3 7.7 11.5 5.8 7.6 1.2 4.1 1 1 4 5 5 5 0 Family of unknown function (DUF5344) UBX PF00789.20 KOG98557.1 - 2.8e-22 78.7 0.0 7.4e-22 77.4 0.0 1.8 1 0 0 1 1 1 1 UBX domain BPL_LplA_LipB PF03099.19 KOG98559.1 - 8.2e-06 25.8 0.3 0.00026 20.9 0.3 2.5 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DUF1128 PF06569.11 KOG98559.1 - 0.055 13.5 0.5 0.59 10.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1128) FAD_binding_2 PF00890.24 KOG98560.1 - 5e-122 408.0 3.2 6.2e-122 407.7 3.2 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 KOG98560.1 - 3.1e-45 153.3 0.6 4.8e-45 152.7 0.6 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 KOG98560.1 - 5.3e-06 25.8 3.5 0.00077 18.6 0.3 2.7 3 0 0 3 3 3 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 KOG98560.1 - 8.7e-06 25.2 0.7 4.3e-05 22.9 0.7 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOG98560.1 - 0.0001 21.7 0.2 0.01 15.1 0.1 2.5 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 KOG98560.1 - 0.0034 17.0 1.7 0.011 15.4 1.7 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 KOG98560.1 - 0.0036 16.6 0.1 0.0082 15.4 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 KOG98560.1 - 0.011 14.5 0.2 0.068 11.9 0.0 2.3 3 0 0 3 3 3 0 HI0933-like protein BNIP2 PF12496.8 KOG98560.1 - 0.055 13.9 0.3 0.1 13.0 0.3 1.4 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Pyr_redox_3 PF13738.6 KOG98560.1 - 0.49 9.6 2.5 6.2 6.0 1.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase RabGAP-TBC PF00566.18 KOG98561.1 - 7.2e-19 68.3 4.7 7.2e-19 68.3 4.7 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Protein_K PF12283.8 KOG98561.1 - 0.042 14.1 0.0 0.16 12.2 0.0 2.0 1 0 0 1 1 1 0 Bacteriophage protein K UL17 PF17640.2 KOG98561.1 - 0.046 13.7 0.1 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized UL17 Pas_Saposin PF09016.10 KOG98561.1 - 0.67 10.3 2.9 1.4 9.4 0.6 2.3 2 0 0 2 2 2 0 Pas factor saposin fold KaiA PF07688.12 KOG98563.1 - 0.16 12.1 1.0 0.38 10.9 1.0 1.6 1 0 0 1 1 1 0 KaiA C-terminal domain Nsp1_C PF05064.13 KOG98564.1 - 1.2e-12 47.7 2.1 1.2e-12 47.7 2.1 2.2 1 1 1 2 2 2 1 Nsp1-like C-terminal region CLZ PF16526.5 KOG98564.1 - 0.0013 19.0 6.1 0.3 11.5 0.3 2.8 2 1 1 3 3 2 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels FlaG PF03646.15 KOG98564.1 - 0.0051 17.0 3.2 0.0051 17.0 3.2 2.1 2 0 0 2 2 2 1 FlaG protein WXG100 PF06013.12 KOG98564.1 - 0.0084 16.3 4.0 0.0084 16.3 4.0 1.8 2 1 0 2 2 1 1 Proteins of 100 residues with WXG APG6_N PF17675.1 KOG98564.1 - 0.013 16.0 9.4 0.016 15.7 9.4 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region KIP1 PF07765.12 KOG98564.1 - 0.015 15.4 4.3 0.11 12.7 0.9 2.4 1 1 2 3 3 3 0 KIP1-like protein CENP-F_leu_zip PF10473.9 KOG98564.1 - 0.017 15.2 7.6 0.048 13.7 7.6 1.7 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 STAT_alpha PF01017.20 KOG98564.1 - 0.022 14.7 6.4 0.032 14.1 6.4 1.2 1 0 0 1 1 1 0 STAT protein, all-alpha domain Baculo_PEP_C PF04513.12 KOG98564.1 - 0.029 14.4 15.5 0.051 13.6 15.3 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc24 PF08286.11 KOG98564.1 - 0.032 14.4 5.2 0.032 14.4 5.2 2.4 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 TssC PF17541.2 KOG98564.1 - 0.061 12.1 8.5 0.074 11.9 8.5 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB DUF948 PF06103.11 KOG98564.1 - 0.096 13.0 5.2 0.29 11.4 1.6 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Muted PF14942.6 KOG98564.1 - 0.099 13.0 7.0 0.095 13.0 5.9 1.6 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein OmpH PF03938.14 KOG98564.1 - 0.1 12.9 5.6 0.14 12.5 5.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) V-SNARE PF05008.15 KOG98564.1 - 0.12 12.7 6.9 2.3 8.7 0.3 2.8 1 1 2 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Ax_dynein_light PF10211.9 KOG98564.1 - 0.14 12.1 9.8 0.13 12.2 2.5 2.1 1 1 0 2 2 2 0 Axonemal dynein light chain DUF1664 PF07889.12 KOG98564.1 - 0.16 12.0 6.8 0.29 11.2 2.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Prefoldin_2 PF01920.20 KOG98564.1 - 0.32 11.0 7.9 4 7.5 5.0 2.8 2 1 0 2 2 2 0 Prefoldin subunit Streptin-Immun PF11083.8 KOG98564.1 - 0.33 11.4 9.1 2.2 8.7 0.3 2.6 2 1 0 2 2 2 0 Lantibiotic streptin immunity protein DUF4407 PF14362.6 KOG98564.1 - 0.49 9.7 4.2 0.67 9.3 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FlaC_arch PF05377.11 KOG98564.1 - 0.51 10.8 8.7 3.7 8.0 1.1 3.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Laminin_II PF06009.12 KOG98564.1 - 0.66 10.0 13.7 0.64 10.0 9.0 2.0 1 1 1 2 2 2 0 Laminin Domain II DUF4200 PF13863.6 KOG98564.1 - 0.78 10.2 8.2 3.7 8.0 8.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) RNA_polI_A14 PF08203.11 KOG98564.1 - 1 10.1 6.2 0.69 10.7 4.0 1.9 1 1 1 2 2 2 0 Yeast RNA polymerase I subunit RPA14 FliD_N PF02465.18 KOG98564.1 - 1.4 9.6 15.5 11 6.8 2.0 2.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus NPV_P10 PF05531.12 KOG98564.1 - 1.6 9.3 10.4 0.81 10.2 2.4 3.0 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein PDDEXK_6 PF04720.12 KOG98564.1 - 1.6 8.6 4.7 2 8.3 4.7 1.3 1 0 0 1 1 1 0 PDDEXK-like family of unknown function zf-CpG_bind_C PF12269.8 KOG98564.1 - 1.9 8.2 6.5 2 8.1 1.4 2.0 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain XhlA PF10779.9 KOG98564.1 - 2 8.7 8.1 7.8 6.8 0.3 3.0 2 1 0 3 3 3 0 Haemolysin XhlA DUF5426 PF17473.2 KOG98564.1 - 4.6 7.5 7.8 11 6.3 1.9 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5426) Nup192 PF11894.8 KOG98565.1 - 0 1699.0 52.4 0 1698.9 52.4 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 DUF1344 PF07076.11 KOG98565.1 - 0.011 15.6 0.5 0.034 14.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1344) PNK3P PF08645.11 KOG98566.1 - 0.087 12.5 1.4 0.16 11.7 0.3 1.8 1 1 1 2 2 2 0 Polynucleotide kinase 3 phosphatase DUF5093 PF17011.5 KOG98566.1 - 0.52 10.6 9.6 0.97 9.7 5.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5093) DUF2072 PF09845.9 KOG98566.1 - 5.6 7.2 8.6 4.1 7.7 3.0 2.1 1 1 1 2 2 2 0 Zn-ribbon containing protein HMA PF00403.26 KOG98567.1 - 0.11 12.9 0.8 0.34 11.4 0.0 2.2 2 1 1 3 3 3 0 Heavy-metal-associated domain DUF2228 PF10228.9 KOG98567.1 - 0.44 10.2 4.1 0.28 10.9 1.7 1.7 1 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) PRKG1_interact PF15898.5 KOG98567.1 - 1.4 9.9 5.8 0.37 11.7 0.3 2.2 1 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF948 PF06103.11 KOG98567.1 - 6.4 7.1 7.1 13 6.1 0.6 2.7 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) PX PF00787.24 KOG98568.1 - 5e-24 84.5 0.8 1.3e-23 83.1 0.1 2.1 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 KOG98568.1 - 7.8e-05 22.3 16.2 0.00012 21.8 3.2 2.3 2 0 0 2 2 2 1 Vps5 C terminal like Baculo_PEP_C PF04513.12 KOG98568.1 - 0.0065 16.5 4.2 0.12 12.4 0.4 2.3 1 1 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus ATG16 PF08614.11 KOG98568.1 - 0.017 15.4 7.5 0.78 9.9 2.2 2.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DASH_Dam1 PF08653.10 KOG98568.1 - 0.031 14.1 1.5 8.6 6.3 0.2 3.7 2 1 1 3 3 2 0 DASH complex subunit Dam1 ING PF12998.7 KOG98568.1 - 0.034 14.7 2.4 0.034 14.7 2.4 2.8 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding NPV_P10 PF05531.12 KOG98568.1 - 0.07 13.6 6.0 27 5.3 3.6 3.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein GreA_GreB_N PF03449.15 KOG98568.1 - 0.08 13.1 6.6 22 5.3 0.4 5.0 5 0 0 5 5 5 0 Transcription elongation factor, N-terminal Allexi_40kDa PF05549.11 KOG98568.1 - 0.085 12.4 4.7 0.3 10.6 1.3 2.3 2 0 0 2 2 2 0 Allexivirus 40kDa protein DUF4618 PF15397.6 KOG98568.1 - 0.098 12.1 20.1 0.061 12.7 13.2 2.8 2 2 2 4 4 4 0 Domain of unknown function (DUF4618) DUF4391 PF14335.6 KOG98568.1 - 0.2 11.3 9.4 0.023 14.4 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4391) FlaC_arch PF05377.11 KOG98568.1 - 0.55 10.7 8.8 5.9 7.4 0.4 3.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) T3SSipB PF16535.5 KOG98568.1 - 0.7 10.4 5.8 0.59 10.6 0.5 2.7 2 1 0 2 2 2 0 Type III cell invasion protein SipB DUF1664 PF07889.12 KOG98568.1 - 0.71 9.9 9.5 3.7 7.6 4.3 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 KOG98568.1 - 0.91 8.7 13.1 0.079 12.2 2.8 2.5 1 1 0 2 2 2 0 TMPIT-like protein Chalcone_3 PF16036.5 KOG98568.1 - 1 9.4 6.4 0.77 9.9 2.4 2.4 1 1 2 3 3 3 0 Chalcone isomerase-like RPW8 PF05659.11 KOG98568.1 - 1.2 8.9 12.8 3.6 7.3 6.3 3.4 2 2 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF948 PF06103.11 KOG98568.1 - 1.2 9.4 9.6 0.44 10.8 1.8 3.3 3 1 1 4 4 3 0 Bacterial protein of unknown function (DUF948) Cep57_CLD_2 PF14197.6 KOG98568.1 - 1.3 9.2 7.0 2.4 8.3 1.9 2.8 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Sec34 PF04136.15 KOG98568.1 - 1.6 8.6 12.9 0.37 10.7 6.6 2.5 2 1 0 2 2 2 0 Sec34-like family Apolipoprotein PF01442.18 KOG98568.1 - 1.6 8.6 9.7 0.44 10.4 3.3 2.9 1 1 2 3 3 3 0 Apolipoprotein A1/A4/E domain PhoU PF01895.19 KOG98568.1 - 2.2 8.8 11.2 0.33 11.4 0.5 3.7 1 1 2 3 3 3 0 PhoU domain Laminin_II PF06009.12 KOG98568.1 - 3.3 7.7 8.1 1.6 8.7 1.5 2.7 2 1 1 3 3 3 0 Laminin Domain II DUF4407 PF14362.6 KOG98568.1 - 3.6 6.8 6.9 9.4 5.5 0.7 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) TMF_TATA_bd PF12325.8 KOG98568.1 - 3.7 7.8 14.7 1.7 8.9 1.1 2.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF3552 PF12072.8 KOG98568.1 - 4.6 6.6 13.9 0.49 9.8 5.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) bZIP_1 PF00170.21 KOG98568.1 - 5.2 7.2 11.9 20 5.4 0.7 3.7 2 1 1 3 3 3 0 bZIP transcription factor Snapin_Pallidin PF14712.6 KOG98568.1 - 6.6 7.2 10.1 5.8 7.4 0.9 3.7 3 1 2 5 5 4 0 Snapin/Pallidin dCMP_cyt_deam_1 PF00383.23 KOG98569.1 - 3.8e-22 78.1 0.1 5.4e-22 77.6 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KOG98569.1 - 5.3e-15 55.4 0.0 8.1e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 KOG98569.1 - 0.00085 19.4 0.3 0.075 13.1 0.3 2.3 1 1 0 1 1 1 1 Bd3614-like deaminase APOBEC_N PF08210.11 KOG98569.1 - 0.0013 18.7 0.0 0.002 18.0 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain NAD1 PF18778.1 KOG98569.1 - 0.0026 17.9 0.0 0.0057 16.8 0.0 1.5 2 0 0 2 2 2 1 Novel AID APOBEC clade 1 SNAD4 PF18750.1 KOG98569.1 - 0.0046 17.0 0.0 0.0081 16.3 0.0 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 KOG98569.1 - 0.027 14.5 0.0 0.047 13.7 0.0 1.3 1 0 0 1 1 1 0 APOBEC2 APOBEC3 PF18771.1 KOG98569.1 - 0.11 12.7 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 APOBEC3 HSP70 PF00012.20 KOG98570.1 - 1.7e-260 865.3 12.7 2e-260 865.2 12.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOG98570.1 - 1.4e-18 66.8 1.3 3.9e-17 62.1 0.2 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 KOG98570.1 - 8.9e-05 22.9 4.3 0.95 9.9 0.2 3.8 3 2 0 3 3 3 2 Cell division protein FtsA Radial_spoke_3 PF06098.11 KOG98570.1 - 0.0035 16.7 0.9 0.0073 15.6 0.9 1.4 1 0 0 1 1 1 1 Radial spoke protein 3 BcrAD_BadFG PF01869.20 KOG98570.1 - 0.0063 16.1 0.3 0.049 13.1 0.3 2.1 1 1 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.18 KOG98570.1 - 0.0095 15.2 2.1 0.2 10.9 0.0 3.0 2 1 0 3 3 3 1 Hydantoinase/oxoprolinase LepB_N PF18640.1 KOG98570.1 - 0.016 14.8 0.0 0.1 12.2 0.0 2.2 2 0 0 2 2 2 0 LepB N-terminal domain DUF5300 PF17224.3 KOG98570.1 - 0.93 9.8 4.9 8 6.8 0.2 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF5300) DEAD PF00270.29 KOG98571.1 - 5.1e-48 163.1 0.1 2.3e-47 161.0 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG98571.1 - 9.5e-25 87.1 0.2 5.1e-24 84.8 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KOG98571.1 - 1.4e-20 73.3 0.0 3.1e-20 72.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KOG98571.1 - 1.5e-08 34.9 0.0 1.5e-08 34.9 0.0 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DUF5623 PF18536.1 KOG98571.1 - 0.02 15.1 0.1 0.053 13.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5623) CMS1 PF14617.6 KOG98571.1 - 0.031 13.6 0.1 0.031 13.6 0.1 3.7 3 1 1 4 4 4 0 U3-containing 90S pre-ribosomal complex subunit PPTA PF01239.22 KOG98572.1 - 1.9e-30 103.7 16.3 5.9e-09 35.4 0.0 4.6 4 0 0 4 4 4 4 Protein prenyltransferase alpha subunit repeat DUF4219 PF13961.6 KOG98572.1 - 0.048 13.3 5.0 0.44 10.3 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) QueH PF02677.14 KOG98572.1 - 0.23 11.6 2.3 0.45 10.6 2.2 1.7 1 1 0 1 1 1 0 Epoxyqueuosine reductase QueH HORMA PF02301.18 KOG98573.1 - 2.2e-23 82.9 0.2 4.2e-23 82.1 0.2 1.4 1 1 0 1 1 1 1 HORMA domain ATG101 PF07855.12 KOG98573.1 - 0.0035 17.3 0.5 0.016 15.2 0.5 1.8 1 1 0 1 1 1 1 Autophagy-related protein 101 ATG13 PF10033.9 KOG98573.1 - 0.07 12.8 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 13 bacHORMA_2 PF18173.1 KOG98573.1 - 0.1 12.5 0.4 0.29 11.0 0.1 1.9 2 1 0 2 2 2 0 Bacterial HORMA domain 2 V-set_CD47 PF08204.11 KOG98573.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain ILEI PF15711.5 KOG98573.1 - 0.22 12.1 0.5 17 6.0 0.0 2.9 3 0 0 3 3 3 0 Interleukin-like EMT inducer Vps53_N PF04100.12 KOG98574.1 - 1e-117 393.3 13.7 1.8e-117 392.5 13.7 1.4 1 0 0 1 1 1 1 Vps53-like, N-terminal VPS53_C PF16854.5 KOG98574.1 - 2.2e-88 295.5 4.2 4.5e-88 294.4 4.2 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 53 C-terminus Ribonuc_red_sm PF00268.21 KOG98576.1 - 2e-114 381.8 1.5 3.2e-114 381.1 1.5 1.3 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain RE_XcyI PF09571.10 KOG98576.1 - 0.06 12.6 0.4 3.6 6.8 0.0 2.2 2 0 0 2 2 2 0 XcyI restriction endonuclease Exonuc_VII_L PF02601.15 KOG98576.1 - 0.065 12.8 0.7 0.084 12.4 0.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4744 PF15918.5 KOG98576.1 - 0.087 13.7 0.0 0.2 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) GIDA_assoc PF13932.6 KOG98576.1 - 2.6 8.2 5.8 4.3 7.5 5.8 1.3 1 0 0 1 1 1 0 GidA associated domain zf-RRN7 PF11781.8 KOG98577.1 - 1.7e-09 37.2 0.7 3.1e-09 36.4 0.7 1.5 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Cullin_Nedd8 PF10557.9 KOG98577.1 - 0.019 15.0 0.1 0.055 13.5 0.1 1.8 1 0 0 1 1 1 0 Cullin protein neddylation domain TetR_C_30 PF17939.1 KOG98577.1 - 0.16 12.2 0.0 0.38 11.0 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Lipoprotein_10 PF03202.13 KOG98577.1 - 4.2 7.8 8.8 2.2 8.7 2.8 2.7 3 0 0 3 3 3 0 Putative mycoplasma lipoprotein, C-terminal region Clat_adaptor_s PF01217.20 KOG98578.1 - 1.7e-39 135.0 3.6 2.1e-39 134.7 3.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SH3_1 PF00018.28 KOG98580.1 - 2.6e-08 33.3 0.2 7.7e-08 31.8 0.2 1.9 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KOG98580.1 - 1.8e-06 27.5 0.0 4e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KOG98580.1 - 0.00022 21.0 0.2 0.00048 19.9 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain Sad1_UNC PF07738.13 KOG98581.1 - 5.5e-06 26.4 1.1 0.00032 20.7 0.1 2.9 2 1 0 2 2 2 1 Sad1 / UNC-like C-terminal Cas_Csd1 PF09709.10 KOG98581.1 - 0.0069 15.1 1.1 0.013 14.2 0.1 1.9 2 0 0 2 2 2 1 CRISPR-associated protein (Cas_Csd1) Baculo_PEP_C PF04513.12 KOG98581.1 - 0.25 11.4 7.6 0.044 13.8 3.5 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Phasin PF05597.11 KOG98581.1 - 0.27 11.3 1.8 0.7 9.9 0.2 2.2 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF1539 PF07560.11 KOG98581.1 - 0.35 11.0 10.9 0.033 14.3 3.1 2.6 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1539) DUF4455 PF14643.6 KOG98581.1 - 0.49 9.0 15.4 0.12 11.0 8.5 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4455) Hat1_N PF10394.9 KOG98581.1 - 0.63 10.3 5.9 9.4 6.5 0.8 3.0 3 0 0 3 3 3 0 Histone acetyl transferase HAT1 N-terminus DUF3437 PF11919.8 KOG98581.1 - 0.98 9.4 5.4 0.22 11.4 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) SKA2 PF16740.5 KOG98581.1 - 3 7.6 9.2 5.7 6.8 1.6 2.6 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Jnk-SapK_ap_N PF09744.9 KOG98581.1 - 4.5 7.5 14.4 6.6 6.9 2.8 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 NOA36 PF06524.12 KOG98581.1 - 8.5 5.6 18.2 16 4.7 18.2 1.4 1 0 0 1 1 1 0 NOA36 protein Cpn60_TCP1 PF00118.24 KOG98583.1 - 2.1e-163 544.5 4.9 2.4e-163 544.3 4.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family NusA_N PF08529.11 KOG98583.1 - 0.12 12.8 2.7 0.12 12.7 0.6 2.2 2 0 0 2 2 2 0 NusA N-terminal domain Mad3_BUB1_I PF08311.12 KOG98584.1 - 8.4e-41 138.8 0.3 1.5e-40 138.0 0.3 1.4 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.11 KOG98584.1 - 1.4e-26 92.5 2.0 3.1e-26 91.3 1.3 2.0 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Mad3_BUB1_I_2 PF17014.5 KOG98584.1 - 2.1e-06 27.9 0.8 2.1e-06 27.9 0.8 2.0 2 0 0 2 2 2 1 Putative Mad3/BUB1 like region 1 protein VTC PF09359.10 KOG98585.1 - 2.3e-101 338.8 0.2 2.3e-101 338.8 0.2 1.5 2 0 0 2 2 2 1 VTC domain SPX PF03105.19 KOG98585.1 - 1.8e-10 41.3 12.7 2.3e-05 24.5 0.7 3.9 3 1 1 4 4 4 3 SPX domain DUF202 PF02656.15 KOG98585.1 - 1.8e-08 34.7 3.5 1.8e-08 34.7 3.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) RNA_pol_Rpb4 PF03874.16 KOG98586.1 - 3.2e-31 108.2 1.7 3.9e-31 108.0 1.7 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 PUF PF00806.19 KOG98587.1 - 2.9e-33 111.6 12.3 0.00029 20.4 0.0 9.0 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat Cpn60_TCP1 PF00118.24 KOG98588.1 - 7.7e-154 513.0 7.7 8.7e-154 512.8 7.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nitro_FeMo-Co PF02579.17 KOG98588.1 - 0.022 15.1 0.1 0.21 11.9 0.0 2.6 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor Cyclin_N PF00134.23 KOG98589.1 - 1.3e-08 34.6 2.5 2.6e-08 33.6 2.5 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain PP2C PF00481.21 KOG98590.1 - 9e-56 189.4 0.1 2.3e-55 188.0 0.1 1.8 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 KOG98590.1 - 1.5e-37 127.1 70.0 3.1e-09 36.5 5.4 9.9 6 3 3 10 10 10 8 Leucine rich repeat LRR_4 PF12799.7 KOG98590.1 - 3.5e-28 97.2 82.9 0.00022 21.5 1.3 12.2 7 3 5 12 12 12 10 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 KOG98590.1 - 5.9e-28 97.7 0.0 1.2e-27 96.7 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Ad_cyc_g-alpha PF08509.11 KOG98590.1 - 2e-08 33.8 0.2 4.6e-08 32.7 0.2 1.7 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_9 PF14580.6 KOG98590.1 - 0.00013 21.5 31.3 0.0044 16.5 6.6 5.0 3 1 2 5 5 5 4 Leucine-rich repeat PP2C_2 PF13672.6 KOG98590.1 - 0.028 14.1 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein phosphatase 2C LRR_1 PF00560.33 KOG98590.1 - 0.099 13.3 47.6 30 5.7 1.4 14.2 11 4 1 12 12 12 0 Leucine Rich Repeat SYS1 PF09801.9 KOG98591.1 - 2.8e-51 173.5 12.3 3.3e-51 173.2 12.3 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network COX16 PF14138.6 KOG98592.1 - 3.9e-29 101.0 0.1 7e-29 100.2 0.1 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 SieB PF14163.6 KOG98592.1 - 0.17 11.4 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Super-infection exclusion protein B Ribophorin_I PF04597.14 KOG98593.1 - 1.1e-129 433.6 6.6 1.2e-129 433.4 6.6 1.0 1 0 0 1 1 1 1 Ribophorin I Mg296 PF09644.10 KOG98593.1 - 3.1 8.0 5.7 9.7 6.3 0.7 3.1 3 0 0 3 3 3 0 Mg296 protein Aa_trans PF01490.18 KOG98594.1 - 1.6e-88 297.2 20.9 1.9e-88 297.0 20.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Mpp10 PF04006.12 KOG98595.1 - 2.6e-143 478.7 52.1 3.5e-143 478.3 52.1 1.0 1 0 0 1 1 1 1 Mpp10 protein Histidinol_dh PF00815.20 KOG98595.1 - 0.013 14.5 2.2 0.024 13.7 0.9 2.1 1 1 0 1 1 1 0 Histidinol dehydrogenase SOGA PF11365.8 KOG98595.1 - 0.023 15.8 0.2 0.023 15.8 0.2 3.4 3 0 0 3 3 3 0 Protein SOGA SbcD_C PF12320.8 KOG98595.1 - 0.22 11.8 0.1 0.22 11.8 0.1 3.1 3 1 1 4 4 4 0 Type 5 capsule protein repressor C-terminal domain Candida_ALS_N PF11766.8 KOG98597.1 - 1.6e-73 247.0 7.5 2.1e-73 246.6 7.5 1.2 1 0 0 1 1 1 1 Cell-wall agglutinin N-terminal ligand-sugar binding SprB PF13573.6 KOG98597.1 - 0.00087 19.0 5.2 0.0041 16.9 0.7 3.0 2 0 0 2 2 2 1 SprB repeat Big_8 PF17961.1 KOG98597.1 - 0.0025 17.9 0.2 0.0025 17.9 0.2 2.1 2 0 0 2 2 2 1 Bacterial Ig domain Flocculin PF00624.18 KOG98597.1 - 0.0037 17.5 26.7 0.0037 17.5 26.7 3.1 4 0 0 4 4 4 1 Flocculin repeat Adaptin_N PF01602.20 KOG98598.1 - 4.4e-110 368.7 17.5 5.5e-110 368.4 17.5 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KOG98598.1 - 5.8e-12 45.9 0.8 5.8e-12 45.9 0.8 3.2 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 FANCI_S2 PF14676.6 KOG98598.1 - 0.17 12.2 2.1 0.64 10.3 0.8 2.5 2 0 0 2 2 2 0 FANCI solenoid 2 eIF3_subunit PF08597.10 KOG98599.1 - 5.8 6.8 16.6 6.4 6.6 16.6 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DNA_pol_E_B PF04042.16 KOG98600.1 - 3.9e-52 176.7 0.1 5.4e-52 176.2 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 KOG98600.1 - 7.1e-38 129.7 0.0 1.9e-37 128.3 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase delta subunit OB-fold domain EIF_2_alpha PF07541.12 KOG98601.1 - 9.3e-38 128.9 0.8 1.5e-37 128.2 0.2 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 KOG98601.1 - 2.4e-14 53.4 0.7 2.4e-14 53.4 0.7 1.8 2 0 0 2 2 2 1 S1 RNA binding domain EXOSC1 PF10447.9 KOG98601.1 - 0.039 14.6 2.9 0.22 12.1 0.3 2.3 2 0 0 2 2 2 0 Exosome component EXOSC1/CSL4 LZ3wCH PF18517.1 KOG98601.1 - 0.54 10.4 0.0 0.54 10.4 0.0 3.0 4 1 1 5 5 5 0 Leucine zipper with capping helix domain Memo PF01875.17 KOG98602.1 - 1e-105 352.8 0.3 1.2e-105 352.6 0.3 1.0 1 0 0 1 1 1 1 Memo-like protein Gp_dh_C PF02800.20 KOG98603.1 - 4.8e-72 240.7 0.1 8.4e-72 239.9 0.1 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 KOG98603.1 - 1.1e-38 131.6 0.0 2.7e-38 130.4 0.0 1.7 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 KOG98603.1 - 0.011 15.9 1.7 0.017 15.3 0.4 2.2 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.19 KOG98603.1 - 0.079 12.3 0.1 0.22 10.9 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ATP-sulfurylase PF01747.17 KOG98604.1 - 1.6e-86 289.2 0.0 2.1e-86 288.8 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 KOG98604.1 - 2.4e-49 167.1 0.0 3.8e-49 166.4 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain CTP_transf_like PF01467.26 KOG98604.1 - 0.071 13.3 0.0 0.22 11.7 0.0 1.8 1 1 0 1 1 1 0 Cytidylyltransferase-like SPC12 PF06645.13 KOG98605.1 - 1e-23 83.2 1.3 1.2e-23 82.9 1.3 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) LapA_dom PF06305.11 KOG98605.1 - 0.71 9.7 3.3 11 5.9 0.7 2.2 1 1 1 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF1688 PF07958.11 KOG98606.1 - 0.083 11.6 0.1 0.11 11.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1688) Tiam_CC_Ex PF18385.1 KOG98606.1 - 0.11 12.9 2.6 0.27 11.6 0.0 2.3 2 1 0 2 2 2 0 T-lymphoma invasion and metastasis CC-Ex domain DUF5572 PF17733.1 KOG98607.1 - 4.1e-10 39.3 0.1 7.5e-10 38.5 0.1 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Involucrin_N PF10583.9 KOG98607.1 - 0.041 14.5 1.6 0.056 14.0 1.6 1.2 1 0 0 1 1 1 0 Involucrin of squamous epithelia N-terminus Mannosyl_trans PF05007.13 KOG98608.1 - 2.2e-101 339.1 17.8 2.2e-101 339.1 17.8 1.9 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 KOG98608.1 - 7.1e-14 51.6 6.2 7.1e-14 51.6 6.2 1.9 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U GT87 PF09594.10 KOG98608.1 - 3e-10 40.2 3.6 3e-10 40.2 3.6 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 87 PMT_2 PF13231.6 KOG98608.1 - 1.8e-05 25.0 7.6 1.8e-05 25.0 7.6 2.6 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase SUI1 PF01253.22 KOG98609.1 - 6.6e-20 71.4 1.6 6.6e-20 71.4 1.6 1.8 1 1 0 1 1 1 1 Translation initiation factor SUI1 DUF3271 PF11675.8 KOG98609.1 - 0.0041 16.4 1.1 0.0055 16.0 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3271) Svf1 PF08622.10 KOG98609.1 - 0.015 15.4 0.2 0.02 14.9 0.2 1.1 1 0 0 1 1 1 0 Svf1-like N-terminal lipocalin domain ILVD_EDD PF00920.21 KOG98610.1 - 6e-209 695.0 0.1 6.8e-209 694.8 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family Rotamase PF00639.21 KOG98611.1 - 1e-25 90.5 0.0 1.5e-25 90.0 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KOG98611.1 - 1.2e-20 74.2 0.0 1.8e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 KOG98611.1 - 8.4e-08 32.2 3.4 1.3e-07 31.5 3.4 1.3 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.6 KOG98611.1 - 3.8e-07 31.0 0.0 5.8e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Acyl_CoA_thio PF02551.15 KOG98612.1 - 2.3e-55 186.0 3.6 3.5e-40 136.9 1.0 3.1 2 1 0 2 2 2 2 Acyl-CoA thioesterase 4HBT_3 PF13622.6 KOG98612.1 - 1.1e-33 117.6 0.0 3.3e-33 116.0 0.0 1.6 1 1 0 1 1 1 1 Thioesterase-like superfamily LSM PF01423.22 KOG98613.1 - 2.3e-11 43.2 0.2 3.4e-11 42.7 0.2 1.3 1 0 0 1 1 1 1 LSM domain Aldolase_II PF00596.21 KOG98614.1 - 3.1e-44 151.1 0.0 3.7e-44 150.9 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain 3-HAO PF06052.12 KOG98615.1 - 2.1e-75 251.5 0.1 2.5e-75 251.2 0.1 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 KOG98615.1 - 6.6e-05 22.5 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 KOG98615.1 - 0.021 14.4 0.0 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 Cupin zinc_ribbon_10 PF10058.9 KOG98615.1 - 0.023 14.4 1.8 0.48 10.2 0.1 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Sec7 PF01369.20 KOG98617.1 - 1.3e-66 223.8 7.9 1.3e-66 223.8 0.3 4.0 4 1 0 4 4 4 1 Sec7 domain Sec7_N PF12783.7 KOG98617.1 - 5.7e-12 45.8 2.0 5.7e-12 45.8 2.0 3.7 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 KOG98617.1 - 0.00025 20.8 3.0 0.00025 20.8 3.0 4.0 4 0 0 4 4 4 1 Dimerisation and cyclophilin-binding domain of Mon2 ZapD PF07072.11 KOG98617.1 - 0.086 12.6 0.0 0.27 11.0 0.0 1.8 1 0 0 1 1 1 0 Cell division protein Pro_isomerase PF00160.21 KOG98618.1 - 3.4e-40 137.9 0.0 5.3e-40 137.3 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 KOG98618.1 - 2.1e-10 39.9 10.5 6.8e-06 25.8 0.5 3.9 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOG98618.1 - 7.7e-10 38.2 6.9 3.2e-07 29.9 0.7 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOG98618.1 - 5.5e-09 35.5 10.5 2e-05 24.4 0.4 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOG98618.1 - 1.1e-06 28.9 0.3 0.00012 22.3 0.3 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOG98618.1 - 4.8e-05 23.9 0.1 0.00012 22.6 0.1 1.7 2 0 0 2 2 1 1 Tetratricopeptide repeat DUF3856 PF12968.7 KOG98618.1 - 0.013 15.6 0.2 0.027 14.5 0.2 1.5 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) MIT PF04212.18 KOG98618.1 - 0.049 13.7 0.4 0.049 13.7 0.4 2.7 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 KOG98618.1 - 0.098 13.3 0.2 0.098 13.3 0.2 3.3 4 0 0 4 4 3 0 Tetratricopeptide repeat SPO22 PF08631.10 KOG98618.1 - 0.11 11.9 0.5 0.21 11.0 0.5 1.3 1 1 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like DUF357 PF04010.13 KOG98618.1 - 0.12 12.4 1.4 2.4 8.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF357) TPR_7 PF13176.6 KOG98618.1 - 0.23 11.6 0.8 3 8.1 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat PspB PF06667.12 KOG98618.1 - 0.29 11.2 0.7 0.56 10.3 0.7 1.4 1 0 0 1 1 1 0 Phage shock protein B TPR_11 PF13414.6 KOG98618.1 - 0.55 10.0 5.5 5.7 6.7 0.1 3.4 3 1 1 4 4 4 0 TPR repeat Rav1p_C PF12234.8 KOG98619.1 - 1.7e-254 846.0 2.4 6.8e-253 840.8 0.3 2.3 2 0 0 2 2 2 2 RAVE protein 1 C terminal WD40 PF00400.32 KOG98619.1 - 8.8e-06 26.4 4.5 8.3 7.5 0.1 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat Pet191_N PF10203.9 KOG98620.1 - 8.3e-23 80.5 3.0 1.4e-22 79.8 3.0 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 KOG98620.1 - 0.0094 16.0 0.8 4.4 7.4 0.2 2.5 2 0 0 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 KOG98620.1 - 0.026 14.7 1.0 0.61 10.3 0.3 2.5 2 0 0 2 2 2 0 CHCH domain CX9C PF16860.5 KOG98620.1 - 1.6 8.8 6.6 4 7.5 0.3 3.0 3 0 0 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, SNF2_N PF00176.23 KOG98621.1 - 2.9e-75 253.2 0.2 5e-75 252.4 0.2 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOG98621.1 - 6.6e-20 71.5 0.0 3.8e-19 69.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG98621.1 - 6.4e-06 26.3 0.0 6.4e-06 26.3 0.0 3.5 5 0 0 5 5 5 1 Type III restriction enzyme, res subunit HECT PF00632.25 KOG98622.1 - 3e-78 263.4 2.8 6.1e-78 262.4 2.8 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) MDFI PF15316.6 KOG98622.1 - 0.006 16.7 0.8 0.014 15.5 0.8 1.6 1 0 0 1 1 1 1 MyoD family inhibitor DUF4130 PF13566.6 KOG98622.1 - 0.37 10.8 4.1 1.6 8.8 0.4 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4130 Voltage_CLC PF00654.20 KOG98624.1 - 1.6e-77 261.2 23.8 1.6e-77 261.2 23.8 1.7 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 KOG98624.1 - 1.5e-17 63.8 0.1 2.1e-07 31.3 0.0 3.0 3 0 0 3 3 3 2 CBS domain Urb2 PF10441.9 KOG98625.1 - 2.5e-56 190.9 0.9 1.5e-55 188.3 0.9 2.5 2 0 0 2 2 2 1 Urb2/Npa2 family IBV_3A PF03617.13 KOG98625.1 - 0.14 12.2 3.3 0.12 12.4 0.3 2.6 2 0 0 2 2 2 0 IBV 3A protein Nucleopor_Nup85 PF07575.13 KOG98626.1 - 2.2e-186 620.8 2.2 2.6e-186 620.6 2.2 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin CDC27 PF09507.10 KOG98627.1 - 0.0016 17.9 30.9 0.0032 16.9 30.9 1.5 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 Vps55 PF04133.14 KOG98628.1 - 1.6e-42 144.2 7.9 1.8e-42 144.0 7.9 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF998 PF06197.13 KOG98628.1 - 0.21 11.2 3.3 0.23 11.1 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF998) CsgG PF03783.14 KOG98628.1 - 0.28 10.4 0.1 0.39 10.0 0.1 1.1 1 0 0 1 1 1 0 Curli production assembly/transport component CsgG HSP70 PF00012.20 KOG98629.1 - 1.8e-268 891.7 14.2 2e-268 891.6 14.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOG98629.1 - 3.1e-14 52.5 3.0 3.7e-12 45.7 1.0 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 KOG98629.1 - 0.0033 17.2 0.0 0.0084 15.9 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain IL31 PF15209.6 KOG98629.1 - 0.14 12.0 1.0 4 7.2 0.4 2.5 2 0 0 2 2 2 0 Interleukin 31 MRP-S27 PF10037.9 KOG98629.1 - 0.17 10.7 7.5 0.3 9.9 7.5 1.3 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 YlbD_coat PF14071.6 KOG98629.1 - 1.1 9.5 7.9 2 8.6 7.5 1.7 1 1 0 1 1 1 0 Putative coat protein SpoVR PF04293.13 KOG98629.1 - 1.2 7.8 7.0 1.8 7.2 7.0 1.3 1 0 0 1 1 1 0 SpoVR like protein Het-C PF07217.11 KOG98629.1 - 1.3 7.4 6.9 2 6.8 6.9 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF5321 PF17254.2 KOG98629.1 - 1.5 8.3 11.1 0.088 12.2 2.5 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5321) Syntaxin_2 PF14523.6 KOG98629.1 - 2.1 8.8 11.8 4.5 7.7 8.9 2.5 1 1 1 2 2 2 0 Syntaxin-like protein CDT1_C PF16679.5 KOG98630.1 - 1.1e-05 25.7 0.0 3.4e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 DNA replication factor Cdt1 C-terminal domain eIF-5a PF01287.20 KOG98631.1 - 1.2e-29 102.2 0.8 1.7e-29 101.7 0.8 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 KOG98631.1 - 0.00043 20.3 0.0 0.00071 19.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Cytochrom_C PF00034.21 KOG98632.1 - 6.4e-12 46.5 0.5 1.3e-11 45.5 0.5 1.4 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 KOG98632.1 - 1.1e-07 32.1 1.8 1.5e-06 28.4 1.8 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 KOG98632.1 - 0.048 13.4 0.6 0.18 11.5 0.2 1.9 2 0 0 2 2 2 0 Cytochrome c-550 domain NAD_kinase PF01513.21 KOG98633.1 - 3.2e-94 315.4 0.0 4.7e-94 314.9 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 KOG98633.1 - 0.0016 18.1 0.0 0.018 14.6 0.0 2.6 3 0 0 3 3 3 1 Diacylglycerol kinase catalytic domain Isy1 PF06246.12 KOG98634.1 - 1.9e-52 178.4 19.0 1.3e-51 175.6 19.0 1.8 1 1 0 1 1 1 1 Isy1-like splicing family Calci_bind_CcbP PF11535.8 KOG98634.1 - 0.86 10.1 6.1 2.3 8.8 0.7 2.8 2 1 1 3 3 3 0 Calcium binding FAD_binding_2 PF00890.24 KOG98635.1 - 1e-70 238.9 0.0 1.2e-70 238.7 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOG98635.1 - 6.9e-09 35.7 0.0 2.5e-06 27.3 0.0 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOG98635.1 - 4.7e-07 29.9 0.1 1.8e-06 28.1 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KOG98635.1 - 2.1e-05 23.9 0.9 0.017 14.4 0.1 2.5 2 0 0 2 2 2 2 Thi4 family Pyr_redox_2 PF07992.14 KOG98635.1 - 3.1e-05 23.4 2.7 0.00082 18.7 0.2 2.9 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KOG98635.1 - 0.00055 19.1 0.0 0.098 11.7 0.1 2.7 3 0 0 3 3 3 1 Lycopene cyclase protein HI0933_like PF03486.14 KOG98635.1 - 0.00065 18.5 4.2 0.27 9.9 0.1 3.0 3 1 0 3 3 3 2 HI0933-like protein FAD_binding_3 PF01494.19 KOG98635.1 - 0.021 14.1 0.0 0.33 10.2 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain GMC_oxred_N PF00732.19 KOG98635.1 - 0.074 12.4 0.2 2.2 7.6 0.0 2.6 3 0 0 3 3 3 0 GMC oxidoreductase Pyr_redox PF00070.27 KOG98635.1 - 0.24 12.0 1.1 33 5.1 0.0 2.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase BUD22 PF09073.10 KOG98636.1 - 0.084 12.2 13.5 0.11 11.9 13.5 1.2 1 0 0 1 1 1 0 BUD22 LRR_4 PF12799.7 KOG98636.1 - 0.21 12.1 17.5 0.69 10.4 0.4 5.8 6 2 1 7 7 7 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOG98636.1 - 0.31 11.2 5.6 3 8.1 0.0 4.8 6 0 0 6 6 6 0 Leucine Rich repeat KCH PF16944.5 KOG98638.1 - 2e-93 312.8 16.5 2.7e-93 312.3 16.5 1.2 1 0 0 1 1 1 1 Fungal potassium channel Hit1_C PF18268.1 KOG98639.1 - 1.2e-40 137.5 1.0 1.2e-40 137.5 1.0 1.5 2 0 0 2 2 2 1 Hit1 C-terminal zf-HIT PF04438.16 KOG98639.1 - 1.7e-11 43.7 14.0 3.4e-11 42.8 14.0 1.4 1 0 0 1 1 1 1 HIT zinc finger CDC14 PF08045.11 KOG98639.1 - 0.0019 17.4 0.3 0.0024 17.1 0.3 1.1 1 0 0 1 1 1 1 Cell division control protein 14, SIN component YL1_C PF08265.11 KOG98639.1 - 0.012 15.4 0.0 0.037 13.8 0.0 1.8 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain zf-MYND PF01753.18 KOG98639.1 - 0.028 14.5 10.5 0.044 13.9 10.5 1.3 1 0 0 1 1 1 0 MYND finger zf-C6H2 PF15801.5 KOG98639.1 - 0.21 11.9 6.8 0.43 10.9 6.8 1.5 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding GFO_IDH_MocA_C PF02894.17 KOG98640.1 - 0.00016 21.7 0.0 0.00033 20.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain GFO_IDH_MocA PF01408.22 KOG98640.1 - 0.00026 21.8 0.0 0.00038 21.3 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DUF4588 PF15251.6 KOG98641.1 - 8.1e-13 48.7 3.9 1.1e-12 48.3 3.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4588) Cytadhesin_P30 PF07271.11 KOG98641.1 - 0.018 14.6 0.3 0.025 14.1 0.3 1.1 1 0 0 1 1 1 0 Cytadhesin P30/P32 Thymidylate_kin PF02223.17 KOG98642.1 - 6.1e-49 166.2 0.0 7e-49 166.0 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.6 KOG98642.1 - 0.0026 18.3 0.0 0.005 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 KOG98642.1 - 0.083 12.9 0.1 0.18 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain HMW1C_N PF18071.1 KOG98642.1 - 0.11 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 HMW1C N-terminal Clat_adaptor_s PF01217.20 KOG98643.1 - 1.6e-56 190.2 1.9 1.8e-56 190.1 1.9 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Endothelin PF00322.17 KOG98643.1 - 0.21 11.2 2.0 0.64 9.7 0.7 2.1 2 0 0 2 2 2 0 Endothelin family Pkinase PF00069.25 KOG98644.1 - 1.1e-34 120.1 0.0 1.8e-34 119.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98644.1 - 4.6e-14 52.3 0.0 8.1e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOG98644.1 - 0.0042 16.5 0.0 0.0072 15.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family HLH PF00010.26 KOG98645.1 - 2.1e-12 46.8 2.7 2.1e-12 46.8 2.7 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain LicD PF04991.13 KOG98646.1 - 1.8e-54 185.3 3.8 1.8e-54 185.3 3.8 3.1 4 1 0 4 4 4 1 LicD family NDUF_C2 PF06374.11 KOG98646.1 - 0.16 12.1 0.6 2.8 8.1 0.1 2.8 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) CN_hydrolase PF00795.22 KOG98647.1 - 4.6e-16 59.0 0.0 3.2e-15 56.2 0.0 2.0 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase TFIIS_C PF01096.18 KOG98648.1 - 1.5e-17 63.1 1.6 1.5e-17 63.1 1.6 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 KOG98648.1 - 3.9e-17 61.8 10.4 2e-14 53.2 0.8 3.0 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit DZR PF12773.7 KOG98648.1 - 1.9e-05 24.6 6.2 0.036 14.1 0.2 2.7 2 1 0 2 2 2 2 Double zinc ribbon TF_Zn_Ribbon PF08271.12 KOG98648.1 - 0.0019 17.7 6.6 0.046 13.2 2.9 2.8 2 1 0 2 2 2 1 TFIIB zinc-binding IBR PF01485.21 KOG98648.1 - 0.0031 17.7 5.2 0.62 10.3 1.6 2.4 2 1 0 2 2 2 2 IBR domain, a half RING-finger domain zf-ribbon_3 PF13248.6 KOG98648.1 - 0.0054 16.1 13.2 1.6 8.3 0.6 4.2 4 0 0 4 4 4 2 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 KOG98648.1 - 0.006 16.5 2.9 0.026 14.5 0.2 2.4 2 0 0 2 2 2 1 Transposase zinc-ribbon domain zinc_ribbon_2 PF13240.6 KOG98648.1 - 0.0081 15.8 12.5 0.51 10.1 0.8 3.9 3 2 0 3 3 3 1 zinc-ribbon domain C1_1 PF00130.22 KOG98648.1 - 0.0082 16.0 2.1 1.6 8.7 0.1 2.5 2 1 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-H2C2_2 PF13465.6 KOG98648.1 - 0.0089 16.4 3.3 0.35 11.4 0.1 3.4 3 0 0 3 3 3 1 Zinc-finger double domain TackOD1 PF18551.1 KOG98648.1 - 0.012 15.3 5.3 0.85 9.3 0.7 2.3 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 zinc_ribbon_4 PF13717.6 KOG98648.1 - 0.014 15.3 7.2 5.4 7.0 0.2 3.5 3 0 0 3 3 3 0 zinc-ribbon domain tRNA-synt_1f PF01921.18 KOG98648.1 - 0.11 11.4 0.2 0.13 11.2 0.2 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (K) HypA PF01155.19 KOG98648.1 - 0.11 12.5 7.7 6.8 6.8 0.3 3.0 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_7 PF02591.15 KOG98648.1 - 0.13 12.5 6.6 9.1 6.6 0.1 4.2 5 0 0 5 5 4 0 C4-type zinc ribbon domain GATA PF00320.27 KOG98648.1 - 0.13 11.9 0.5 0.13 11.9 0.5 2.9 3 1 0 3 3 3 0 GATA zinc finger Nop10p PF04135.12 KOG98648.1 - 0.13 12.3 1.5 0.27 11.3 0.2 2.2 1 1 1 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family DUF2072 PF09845.9 KOG98648.1 - 0.14 12.5 0.1 0.14 12.5 0.1 2.8 1 1 2 3 3 3 0 Zn-ribbon containing protein zinc-ribbons_6 PF07191.12 KOG98648.1 - 0.14 12.1 7.1 3.7 7.6 0.3 2.6 2 1 0 2 2 2 0 zinc-ribbons DUF3797 PF12677.7 KOG98648.1 - 0.14 12.0 3.7 0.54 10.2 1.8 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3797) Nudix_N_2 PF14803.6 KOG98648.1 - 0.18 11.8 8.7 1.1 9.2 1.3 3.8 3 1 0 3 3 3 0 Nudix N-terminal CpXC PF14353.6 KOG98648.1 - 0.26 11.3 0.1 0.26 11.3 0.1 2.9 1 1 2 3 3 3 0 CpXC protein zf-RING_5 PF14634.6 KOG98648.1 - 0.45 10.5 6.7 3.3 7.7 0.6 2.9 3 0 0 3 3 3 0 zinc-RING finger domain Rubredoxin PF00301.20 KOG98648.1 - 0.52 10.4 5.5 32 4.6 0.3 3.3 3 0 0 3 3 3 0 Rubredoxin zf-CSL PF05207.13 KOG98648.1 - 0.56 10.0 5.0 0.52 10.1 0.2 2.3 2 0 0 2 2 2 0 CSL zinc finger Zn-ribbon_8 PF09723.10 KOG98648.1 - 0.59 10.3 12.3 4.7 7.4 0.1 3.5 3 1 0 3 3 3 0 Zinc ribbon domain zf-TFIIB PF13453.6 KOG98648.1 - 0.71 9.3 6.1 0.13 11.6 0.7 2.2 2 0 0 2 2 2 0 Transcription factor zinc-finger Stc1 PF12898.7 KOG98648.1 - 0.86 10.2 7.9 1.6 9.3 0.6 2.3 1 1 1 2 2 2 0 Stc1 domain Ogr_Delta PF04606.12 KOG98648.1 - 0.92 9.5 9.3 0.37 10.8 4.8 2.4 2 1 0 2 2 2 0 Ogr/Delta-like zinc finger DpnI PF06044.12 KOG98648.1 - 0.95 9.1 4.2 5.4 6.6 0.4 2.1 1 1 0 2 2 2 0 Dam-replacing family Ribosomal_S27e PF01667.17 KOG98648.1 - 1.1 9.0 8.8 29 4.5 0.0 3.8 3 1 0 3 3 3 0 Ribosomal protein S27 OrfB_Zn_ribbon PF07282.11 KOG98648.1 - 1.2 9.1 7.1 14 5.7 2.5 2.7 2 1 0 2 2 2 0 Putative transposase DNA-binding domain zf-RRN7 PF11781.8 KOG98648.1 - 1.3 8.8 0.1 1.3 8.8 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 PADR1 PF08063.12 KOG98648.1 - 1.4 8.8 10.4 20 5.0 0.0 3.5 3 1 0 3 3 3 0 PADR1 (NUC008) domain Baculo_LEF5_C PF11792.8 KOG98648.1 - 1.7 8.4 6.9 0.16 11.6 0.9 2.4 2 1 0 2 2 1 0 Baculoviridae late expression factor 5 C-terminal domain zf-AN1 PF01428.16 KOG98648.1 - 2.3 8.5 9.0 17 5.7 0.2 3.5 3 1 0 3 3 3 0 AN1-like Zinc finger zf-C2H2_4 PF13894.6 KOG98648.1 - 3.4 8.7 11.5 31 5.8 1.1 3.8 4 0 0 4 4 3 0 C2H2-type zinc finger YhfH PF14149.6 KOG98648.1 - 3.5 7.7 10.1 9.5 6.3 0.5 3.7 4 0 0 4 4 4 0 YhfH-like protein Zn_Tnp_IS91 PF14319.6 KOG98648.1 - 4.4 7.4 7.4 3.1 7.9 1.8 2.7 1 1 0 2 2 2 0 Transposase zinc-binding domain Elf1 PF05129.13 KOG98648.1 - 5.1 7.2 9.4 0.59 10.2 1.6 2.4 1 1 0 2 2 2 0 Transcription elongation factor Elf1 like zinc_ribbon_15 PF17032.5 KOG98648.1 - 7.7 7.3 12.0 45 4.9 7.8 3.1 1 1 0 2 2 2 0 zinc-ribbon family zinc_ribbon_6 PF14599.6 KOG98648.1 - 8.1 6.5 8.0 1 9.4 0.2 2.8 2 1 0 2 2 2 0 Zinc-ribbon zf_UBZ PF18439.1 KOG98648.1 - 8.6 6.1 12.6 9.8 5.9 0.2 4.0 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Cpn60_TCP1 PF00118.24 KOG98649.1 - 5.5e-151 503.5 1.4 6.3e-151 503.3 1.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Resolvase PF00239.21 KOG98649.1 - 0.035 14.2 0.3 1 9.5 0.1 2.4 2 0 0 2 2 2 0 Resolvase, N terminal domain Actin PF00022.19 KOG98650.1 - 1e-90 304.3 0.0 2.5e-88 296.4 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 KOG98650.1 - 5.2e-05 22.2 0.0 0.055 12.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 KOG98650.1 - 0.0027 18.1 0.0 0.0085 16.5 0.0 1.9 2 1 0 2 2 2 1 Cell division protein FtsA FAT PF02259.23 KOG98651.1 - 6.1e-130 433.5 1.8 7.9e-130 433.1 0.1 2.1 2 1 1 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.27 KOG98651.1 - 1.4e-73 247.8 0.0 2.9e-73 246.8 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 KOG98651.1 - 8.5e-66 220.8 14.2 1.9e-62 209.9 0.8 5.4 5 0 0 5 5 5 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 KOG98651.1 - 7.1e-41 138.6 3.5 1.4e-40 137.7 0.9 2.9 3 0 0 3 3 3 1 FKBP12-rapamycin binding domain FATC PF02260.20 KOG98651.1 - 1.1e-16 60.4 0.2 3.8e-16 58.6 0.2 2.1 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 KOG98651.1 - 4.3e-13 49.5 1.2 0.023 15.1 0.0 8.3 8 1 0 8 8 7 2 HEAT repeats HEAT_EZ PF13513.6 KOG98651.1 - 6.1e-10 39.4 0.5 0.08 13.5 0.0 9.3 8 1 2 10 10 9 3 HEAT-like repeat HEAT PF02985.22 KOG98651.1 - 5.2e-08 32.5 9.9 0.0067 16.6 0.0 7.8 8 0 0 8 8 5 2 HEAT repeat Vac14_Fab1_bd PF12755.7 KOG98651.1 - 5.3e-06 27.0 4.8 0.24 12.0 0.0 5.8 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region DUF3437 PF11919.8 KOG98651.1 - 0.0074 16.2 0.1 0.33 10.9 0.0 3.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) Cnd1 PF12717.7 KOG98651.1 - 0.029 14.4 8.8 3 7.9 0.5 5.6 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 HrpB1_HrpK PF09613.10 KOG98651.1 - 0.045 13.4 0.0 0.83 9.3 0.0 3.0 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) Telomere_reg-2 PF10193.9 KOG98651.1 - 1.7 9.1 4.2 42 4.6 0.0 4.9 4 0 0 4 4 4 0 Telomere length regulation protein Yae1_N PF09811.9 KOG98652.1 - 2.5e-14 52.7 0.2 3.5e-14 52.2 0.2 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal BBP1_C PF15272.6 KOG98652.1 - 0.071 12.9 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal Rep_fac_C PF08542.11 KOG98653.1 - 4.8e-18 65.4 0.0 1.1e-17 64.2 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 KOG98653.1 - 6.4e-16 59.0 0.0 1.3e-15 58.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 KOG98653.1 - 3.9e-12 46.2 0.0 1.6e-10 41.0 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 KOG98653.1 - 1.2e-07 31.9 0.0 2.3e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 KOG98653.1 - 2.8e-05 23.9 0.0 7.1e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOG98653.1 - 3.2e-05 24.2 0.1 0.00035 20.9 0.0 2.4 2 1 0 2 2 1 1 AAA domain AAA_11 PF13086.6 KOG98653.1 - 4.5e-05 23.4 0.0 0.0001 22.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 KOG98653.1 - 0.00018 21.6 0.0 0.003 17.6 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 KOG98653.1 - 0.00025 21.5 0.0 0.0058 17.0 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_assoc_2 PF16193.5 KOG98653.1 - 0.00037 20.8 0.0 0.00099 19.4 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain Mg_chelatase PF01078.21 KOG98653.1 - 0.00041 19.8 0.0 0.0083 15.5 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 KOG98653.1 - 0.0019 17.4 0.0 0.0028 16.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ResIII PF04851.15 KOG98653.1 - 0.003 17.6 0.0 0.016 15.2 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_7 PF12775.7 KOG98653.1 - 0.003 17.1 0.0 0.0051 16.4 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_30 PF13604.6 KOG98653.1 - 0.005 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOG98653.1 - 0.0051 17.2 0.0 0.021 15.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 KOG98653.1 - 0.01 16.4 0.0 0.021 15.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KOG98653.1 - 0.013 15.2 0.0 0.034 13.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KOG98653.1 - 0.04 13.9 0.1 0.37 10.8 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KOG98653.1 - 0.075 12.9 0.0 0.7 9.8 0.0 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 KOG98653.1 - 0.084 12.1 0.0 0.23 10.6 0.0 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) YAF2_RYBP PF17219.3 KOG98653.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Yaf2/RYBP C-terminal binding motif AAA_18 PF13238.6 KOG98653.1 - 0.12 12.9 0.0 0.31 11.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KOG98653.1 - 0.14 12.4 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Ham1p_like PF01725.16 KOG98654.1 - 1.9e-52 177.9 0.1 2.2e-52 177.7 0.1 1.0 1 0 0 1 1 1 1 Ham1 family DUF3236 PF11576.8 KOG98654.1 - 0.13 11.9 0.4 0.21 11.3 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3236) HEAT_2 PF13646.6 KOG98655.1 - 1.2e-33 115.3 2.4 3e-15 56.4 0.1 3.3 2 1 1 3 3 3 2 HEAT repeats HEAT_PBS PF03130.16 KOG98655.1 - 3.8e-22 76.7 2.3 4.7e-05 23.7 0.0 6.3 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.22 KOG98655.1 - 1.5e-11 43.5 1.1 0.21 11.9 0.0 6.1 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 KOG98655.1 - 2.4e-05 24.7 1.3 3.9 8.1 0.1 5.0 4 1 1 5 5 5 2 HEAT-like repeat Cnd1 PF12717.7 KOG98655.1 - 0.013 15.5 0.6 7.9 6.5 0.0 3.7 4 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 KOG98655.1 - 0.019 15.0 0.2 4.9 7.3 0.0 2.9 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat DUF5635 PF18685.1 KOG98655.1 - 0.032 14.2 0.0 0.11 12.5 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5635) ATP_bind_1 PF03029.17 KOG98656.1 - 1.4e-82 277.1 0.2 2.3e-82 276.4 0.2 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 KOG98656.1 - 1.6e-07 31.0 0.1 5.2e-06 26.1 0.1 2.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 KOG98656.1 - 2.7e-05 24.3 0.0 8.8e-05 22.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 KOG98656.1 - 2.8e-05 23.9 0.1 9.7e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 KOG98656.1 - 0.00028 21.0 0.0 0.0058 16.7 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG98656.1 - 0.00032 20.6 0.1 0.77 9.7 0.0 3.4 2 1 0 2 2 2 2 RsgA GTPase PduV-EutP PF10662.9 KOG98656.1 - 0.00039 20.2 0.0 0.062 13.0 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 KOG98656.1 - 0.00041 20.3 0.0 0.0016 18.4 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 KOG98656.1 - 0.00075 19.8 0.0 0.0026 18.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 KOG98656.1 - 0.0018 17.3 0.0 0.41 9.6 0.0 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB FeoB_N PF02421.18 KOG98656.1 - 0.0022 17.5 0.0 0.056 13.0 0.0 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B PRK PF00485.18 KOG98656.1 - 0.0072 16.1 0.0 0.026 14.3 0.0 1.9 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family SRP54 PF00448.22 KOG98656.1 - 0.0073 15.9 0.0 0.039 13.6 0.0 2.1 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Roc PF08477.13 KOG98656.1 - 0.0097 16.1 0.0 0.91 9.8 0.0 2.8 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG98656.1 - 0.0099 15.3 0.1 0.76 9.2 0.0 3.0 2 1 0 2 2 2 1 ADP-ribosylation factor family CLP1_P PF16575.5 KOG98656.1 - 0.011 15.5 0.2 2.8 7.7 0.0 2.9 4 0 0 4 4 4 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SRPRB PF09439.10 KOG98656.1 - 0.012 15.1 0.2 0.94 8.9 0.0 2.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 KOG98656.1 - 0.015 14.9 0.0 0.032 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 KOG98656.1 - 0.015 15.6 0.0 0.04 14.3 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 KOG98656.1 - 0.017 15.7 0.1 0.061 13.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 KOG98656.1 - 0.017 14.7 0.2 0.21 11.2 0.2 2.4 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 KOG98656.1 - 0.021 14.5 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 KOG98656.1 - 0.031 13.5 1.5 0.076 12.2 0.0 2.2 2 1 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.15 KOG98656.1 - 0.14 12.0 0.0 3.3 7.6 0.0 2.2 2 0 0 2 2 2 0 NTPase G-alpha PF00503.20 KOG98656.1 - 0.21 10.7 3.7 2.6 7.1 0.0 3.2 3 1 1 4 4 4 0 G-protein alpha subunit PEMT PF04191.13 KOG98657.1 - 2.1e-35 121.3 1.6 2.1e-35 121.3 1.6 1.6 2 0 0 2 2 2 1 Phospholipid methyltransferase Gly_transf_sug PF04488.15 KOG98658.1 - 1.7e-16 60.6 0.0 5.9e-16 58.9 0.0 1.9 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif DUF3450 PF11932.8 KOG98658.1 - 0.04 13.2 4.2 0.06 12.6 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) AI-2E_transport PF01594.16 KOG98658.1 - 0.12 11.5 0.3 0.18 10.9 0.3 1.2 1 0 0 1 1 1 0 AI-2E family transporter DUF3379 PF11859.8 KOG98658.1 - 0.82 8.9 5.5 6.1 6.1 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3379) Septin PF00735.18 KOG98659.1 - 1.6e-109 365.6 0.0 2.8e-109 364.8 0.0 1.4 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KOG98659.1 - 2.8e-08 33.8 0.0 8.7e-08 32.2 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 KOG98659.1 - 5.6e-05 23.7 1.1 0.00027 21.4 0.0 2.2 2 0 0 2 2 2 1 ABC transporter Dynamin_N PF00350.23 KOG98659.1 - 5.8e-05 23.2 7.5 0.0016 18.6 0.3 3.0 2 1 1 3 3 3 2 Dynamin family AIG1 PF04548.16 KOG98659.1 - 5.9e-05 22.5 0.1 5.9e-05 22.5 0.1 2.0 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 KOG98659.1 - 0.00036 20.5 1.5 0.00036 20.5 1.5 3.5 3 1 0 3 3 3 1 RsgA GTPase IIGP PF05049.13 KOG98659.1 - 0.0033 16.6 0.1 0.0059 15.7 0.1 1.3 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Roc PF08477.13 KOG98659.1 - 0.01 16.1 0.0 0.023 14.9 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 KOG98659.1 - 0.022 14.5 0.4 0.078 12.7 0.4 2.0 1 1 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.27 KOG98659.1 - 0.029 13.9 0.3 1.2 8.6 0.3 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain cobW PF02492.19 KOG98659.1 - 0.087 12.4 0.2 0.21 11.1 0.2 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain G-alpha PF00503.20 KOG98659.1 - 0.13 11.4 3.8 0.13 11.4 0.1 2.5 3 0 0 3 3 3 0 G-protein alpha subunit PduV-EutP PF10662.9 KOG98659.1 - 0.13 12.0 0.6 5 6.9 0.2 2.4 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 KOG98659.1 - 0.16 11.5 2.6 0.45 10.0 0.4 2.5 2 1 0 2 2 2 0 Ferrous iron transport protein B AAA_23 PF13476.6 KOG98659.1 - 0.96 9.9 12.5 3.9 7.9 0.5 2.6 2 1 0 2 2 2 0 AAA domain Mito_carr PF00153.27 KOG98660.1 - 1.8e-44 149.6 8.3 8e-18 64.2 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein IDO PF01231.18 KOG98661.1 - 1.9e-138 461.9 0.0 2.1e-138 461.8 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.11 KOG98661.1 - 0.026 13.3 0.2 0.18 10.5 0.3 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF1864) AIM24 PF01987.17 KOG98662.1 - 1.7e-31 109.6 0.0 2.2e-31 109.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 NuA4 PF09340.10 KOG98663.1 - 5.9e-23 80.6 4.1 8.7e-23 80.0 4.1 1.3 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 Tmemb_cc2 PF10267.9 KOG98664.1 - 6.3e-05 22.3 5.1 0.00012 21.3 5.1 1.4 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Tropomyosin_1 PF12718.7 KOG98664.1 - 0.0025 18.0 5.8 0.0025 18.0 5.8 1.8 2 0 0 2 2 2 1 Tropomyosin like Lge1 PF11488.8 KOG98664.1 - 0.043 14.0 4.2 0.12 12.6 4.2 1.8 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 CALCOCO1 PF07888.11 KOG98664.1 - 0.13 11.1 5.3 0.21 10.4 5.3 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like LMBR1 PF04791.16 KOG98664.1 - 0.17 10.8 2.7 0.21 10.5 2.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Jnk-SapK_ap_N PF09744.9 KOG98664.1 - 0.74 10.0 7.8 0.14 12.4 3.8 1.8 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 PCI PF01399.27 KOG98665.1 - 1.6e-13 51.0 0.1 5.1e-13 49.4 0.0 1.9 2 0 0 2 2 2 1 PCI domain Picorna_P3A PF06363.11 KOG98665.1 - 0.058 13.3 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Picornaviridae P3A protein Tmemb_14 PF03647.13 KOG98666.1 - 2.1e-21 76.4 8.3 2.3e-21 76.3 8.3 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Aim19 PF10315.9 KOG98666.1 - 0.34 11.2 3.5 1.2 9.4 2.8 2.1 1 1 1 2 2 2 0 Altered inheritance of mitochondria protein 19 G-gamma PF00631.22 KOG98667.1 - 7e-28 96.4 0.2 1.1e-27 95.8 0.2 1.3 1 0 0 1 1 1 1 GGL domain TPR_8 PF13181.6 KOG98668.1 - 0.0021 18.1 5.6 1.9 8.9 0.2 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOG98668.1 - 0.0032 17.5 6.9 0.13 12.4 0.1 3.9 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOG98668.1 - 0.0041 17.6 0.1 0.16 12.5 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOG98668.1 - 0.0046 16.7 1.2 0.17 11.7 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOG98668.1 - 0.0077 16.2 0.1 4.7 7.5 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOG98668.1 - 0.009 16.8 0.4 8.8 7.4 0.0 3.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOG98668.1 - 0.014 16.0 7.7 2.4 9.0 0.1 4.1 4 1 0 4 4 3 0 Tetratricopeptide repeat Ribosomal_L10 PF00466.20 KOG98668.1 - 0.028 14.5 0.7 0.2 11.8 0.0 2.5 2 1 0 2 2 2 0 Ribosomal protein L10 Init_tRNA_PT PF04179.12 KOG98668.1 - 0.054 13.8 0.4 1.5 9.2 0.0 2.8 3 0 0 3 3 3 0 Rit1 DUSP-like domain TPR_12 PF13424.6 KOG98668.1 - 0.073 13.4 1.4 14 6.0 0.0 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOG98668.1 - 0.081 12.6 0.1 0.44 10.3 0.0 2.2 2 0 0 2 2 2 0 TPR repeat TPR_9 PF13371.6 KOG98668.1 - 0.087 13.0 0.0 0.33 11.1 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat BIR PF00653.21 KOG98669.1 - 4.5e-24 84.9 4.5 1.1e-17 64.4 0.5 2.7 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain BRCT_2 PF16589.5 KOG98669.1 - 0.081 13.3 0.1 0.54 10.7 0.0 2.4 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain LRR_4 PF12799.7 KOG98670.1 - 5.9e-07 29.7 17.8 0.73 10.3 0.2 8.6 5 2 3 8 8 8 5 Leucine Rich repeats (2 copies) F-box-like PF12937.7 KOG98670.1 - 1.2e-05 25.0 0.2 2.9e-05 23.8 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOG98670.1 - 0.0056 16.5 0.1 0.017 15.0 0.1 1.9 1 0 0 1 1 1 1 F-box domain PUF PF00806.19 KOG98671.1 - 6.6e-32 107.4 0.0 2.3e-06 27.0 0.1 5.8 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 KOG98671.1 - 4.6e-08 32.8 0.0 1.2e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PH PF00169.29 KOG98672.1 - 3.1e-10 40.5 0.3 3.1e-10 40.5 0.3 3.2 3 0 0 3 3 3 1 PH domain Fip1 PF05182.13 KOG98673.1 - 3.3e-21 74.5 0.5 5.4e-21 73.8 0.5 1.4 1 0 0 1 1 1 1 Fip1 motif SUIM_assoc PF16619.5 KOG98674.1 - 0.027 14.5 5.7 1.6 8.9 3.4 3.3 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Ribosomal_L37ae PF01780.19 KOG98675.1 - 1.3e-40 137.3 9.2 1.5e-40 137.2 9.2 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 KOG98675.1 - 0.0043 17.2 2.6 0.0061 16.7 2.6 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Zn_Tnp_IS1595 PF12760.7 KOG98675.1 - 0.0067 16.4 2.2 0.012 15.6 2.2 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Rep_fac-A_C PF08646.10 KOG98675.1 - 0.0074 16.0 0.3 0.0083 15.9 0.3 1.2 1 0 0 1 1 1 1 Replication factor-A C terminal domain zf-H2C2_2 PF13465.6 KOG98675.1 - 0.032 14.7 1.4 1.1 9.8 0.2 2.3 2 0 0 2 2 2 0 Zinc-finger double domain DUF1364 PF07102.12 KOG98675.1 - 0.052 13.4 1.9 0.08 12.8 1.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1364) Sgf11 PF08209.11 KOG98675.1 - 0.053 13.1 0.4 0.62 9.7 0.0 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) CarbpepA_inh PF02977.15 KOG98675.1 - 0.064 13.1 3.9 0.13 12.1 0.8 2.1 1 1 1 2 2 2 0 Carboxypeptidase A inhibitor zf-ribbon_3 PF13248.6 KOG98675.1 - 0.068 12.6 1.8 4.1 6.9 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain C1_2 PF03107.16 KOG98675.1 - 0.082 13.2 2.6 0.43 10.9 2.7 1.8 1 1 1 2 2 2 0 C1 domain DUF2175 PF09943.9 KOG98675.1 - 0.097 13.0 0.4 4.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) zf-C4_ClpX PF06689.13 KOG98675.1 - 0.23 11.4 3.7 0.33 10.9 0.2 2.4 2 0 0 2 2 2 0 ClpX C4-type zinc finger Mito_carr PF00153.27 KOG98676.1 - 1.5e-74 246.0 0.7 7.4e-24 83.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Aldo_ket_red PF00248.21 KOG98677.1 - 2e-42 145.4 0.0 4e-40 137.8 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family DnaJ PF00226.31 KOG98678.1 - 2.1e-18 66.2 1.2 3.1e-18 65.6 1.2 1.3 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 KOG98678.1 - 8.6e-18 63.8 1.5 1.8e-17 62.8 1.5 1.5 1 0 0 1 1 1 1 CSL zinc finger UBA_2 PF08587.11 KOG98678.1 - 0.019 15.0 2.2 1.2 9.3 0.3 2.6 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) YedD PF13987.6 KOG98678.1 - 0.046 13.5 0.1 0.071 12.9 0.1 1.3 1 0 0 1 1 1 0 YedD-like protein DUF3811 PF11656.8 KOG98678.1 - 0.054 13.9 0.6 0.091 13.2 0.6 1.4 1 0 0 1 1 1 0 YjbD family (DUF3811) LCAT PF02450.15 KOG98679.1 - 1.5e-08 34.3 0.1 3.1e-08 33.2 0.0 1.6 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 KOG98679.1 - 4.2e-06 26.7 0.1 1.4e-05 25.0 0.1 1.8 2 0 0 2 2 2 1 PGAP1-like protein DUF900 PF05990.12 KOG98679.1 - 0.00028 20.5 0.0 0.0006 19.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 KOG98679.1 - 0.0008 20.1 0.0 0.0013 19.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOG98679.1 - 0.001 18.4 0.0 0.0018 17.6 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Palm_thioest PF02089.15 KOG98679.1 - 0.0024 17.7 0.0 0.0057 16.5 0.0 1.6 2 0 0 2 2 2 1 Palmitoyl protein thioesterase Abhydrolase_8 PF06259.12 KOG98679.1 - 0.0046 16.6 0.0 0.0082 15.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase Abhydrolase_5 PF12695.7 KOG98679.1 - 0.023 14.5 0.1 0.088 12.6 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family LIDHydrolase PF10230.9 KOG98679.1 - 0.062 12.8 0.3 0.12 11.9 0.3 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Abhydrolase_1 PF00561.20 KOG98679.1 - 0.064 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 KOG98679.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase CdiI PF07262.11 KOG98679.1 - 2.6 7.8 5.8 12 5.7 0.8 2.9 3 0 0 3 3 3 0 CDI immunity protein Peptidase_C12 PF01088.21 KOG98680.1 - 1.6e-47 162.0 0.0 1.8e-47 161.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Scramblase PF03803.15 KOG98681.1 - 1.5e-78 263.1 0.3 1.8e-78 262.9 0.3 1.1 1 0 0 1 1 1 1 Scramblase Sod_Fe_C PF02777.18 KOG98682.1 - 2e-15 56.8 2.4 2.3e-12 47.0 2.4 2.6 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Pik1 PF11522.8 KOG98682.1 - 0.0048 16.8 0.3 0.0048 16.8 0.3 2.3 3 0 0 3 3 3 1 Yeast phosphatidylinositol-4-OH kinase Pik1 ESCRT-II PF05871.12 KOG98683.1 - 1.4e-47 161.4 1.1 1.7e-47 161.2 1.1 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit CTP_synth_N PF06418.14 KOG98684.1 - 2.8e-124 413.7 0.1 3.6e-124 413.3 0.1 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 KOG98684.1 - 2.1e-59 200.5 0.0 3.4e-59 199.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 KOG98684.1 - 0.015 15.0 0.1 0.12 12.1 0.1 2.3 1 1 0 1 1 1 0 Peptidase C26 DUF5335 PF17269.2 KOG98684.1 - 0.037 13.9 0.2 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5335) Sod_Cu PF00080.20 KOG98685.1 - 7.3e-49 165.6 1.9 8.5e-49 165.4 1.9 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) PfkB PF00294.24 KOG98686.1 - 5.1e-79 265.7 2.3 5.7e-79 265.6 2.3 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 KOG98686.1 - 1.6e-06 27.7 0.0 2.9e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Na_Ca_ex PF01699.24 KOG98687.1 - 1.5e-59 200.3 41.5 1.2e-32 113.0 13.7 3.1 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Pox_ATPase-GT PF10640.9 KOG98687.1 - 0.084 11.7 0.6 0.14 11.0 0.6 1.3 1 0 0 1 1 1 0 mRNA capping enzyme N-terminal, ATPase and guanylyltransferase Lipase_3 PF01764.25 KOG98688.1 - 5.3e-44 149.5 0.0 7.8e-44 149.0 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 KOG98688.1 - 0.01 16.5 0.0 0.014 16.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOG98688.1 - 0.016 14.4 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2974 PF11187.8 KOG98688.1 - 0.039 13.5 0.0 0.91 9.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_5 PF12695.7 KOG98688.1 - 0.05 13.4 0.0 0.075 12.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Cutinase PF01083.22 KOG98688.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Cutinase DUF5137 PF17220.3 KOG98689.1 - 5.8e-20 71.9 2.1 7.9e-20 71.5 2.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF5137) CPSase_L_D2 PF02786.17 KOG98690.1 - 1.2e-108 361.5 0.0 1.4e-82 276.3 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 KOG98690.1 - 3.5e-38 130.7 1.4 4.2e-38 130.4 0.2 1.8 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 KOG98690.1 - 5.5e-17 61.9 0.0 2.9e-07 30.2 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KOG98690.1 - 7.4e-15 55.0 0.4 2.1e-06 27.4 0.1 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 KOG98690.1 - 8.3e-15 54.7 0.0 1.1e-07 31.6 0.0 2.7 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_5 PF13549.6 KOG98690.1 - 2.8e-05 23.7 0.0 0.0093 15.4 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.22 KOG98690.1 - 2.8e-05 24.2 0.0 0.00013 22.1 0.1 2.2 2 0 0 2 2 2 1 MGS-like domain GARS_A PF01071.19 KOG98690.1 - 0.00013 21.8 0.2 0.057 13.2 0.1 2.8 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_4 PF13535.6 KOG98690.1 - 0.0073 15.9 0.1 0.17 11.5 0.1 2.8 2 1 0 2 2 2 1 ATP-grasp domain SPACA9 PF15120.6 KOG98690.1 - 0.0088 15.8 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 Sperm acrosome-associated protein 9 GDP_Man_Dehyd PF16363.5 KOG98690.1 - 0.018 14.5 0.1 0.034 13.6 0.1 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOG98690.1 - 0.081 12.4 0.1 0.27 10.7 0.1 1.8 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Myotub-related PF06602.14 KOG98691.1 - 3.6e-132 440.6 1.5 4.7e-132 440.2 1.5 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 KOG98691.1 - 0.0023 17.5 0.1 0.0056 16.3 0.0 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase GRAM PF02893.20 KOG98691.1 - 0.0028 17.5 0.3 0.0096 15.8 0.0 2.0 2 0 0 2 2 2 1 GRAM domain DSPc PF00782.20 KOG98691.1 - 0.02 14.7 0.2 0.1 12.4 0.0 2.2 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KOG98691.1 - 0.065 13.2 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family CMD PF02627.20 KOG98692.1 - 2.3e-07 30.8 0.0 2.5e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family Nnf1 PF03980.14 KOG98693.1 - 1.7e-29 102.4 4.4 2.2e-29 102.1 3.8 1.5 1 1 0 1 1 1 1 Nnf1 MAP65_ASE1 PF03999.12 KOG98693.1 - 0.0059 15.4 2.7 0.0068 15.2 2.7 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) DUF4407 PF14362.6 KOG98693.1 - 0.008 15.6 0.9 0.011 15.1 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF948 PF06103.11 KOG98693.1 - 0.01 16.1 0.6 1.4 9.3 0.1 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) OmpH PF03938.14 KOG98693.1 - 0.011 16.0 0.6 0.011 16.0 0.6 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Mod_r PF07200.13 KOG98693.1 - 0.02 15.0 2.0 0.02 15.0 2.0 2.1 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Troponin PF00992.20 KOG98693.1 - 0.025 14.9 9.5 0.1 12.9 3.0 2.2 2 0 0 2 2 2 0 Troponin LRRFIP PF09738.9 KOG98693.1 - 0.031 13.8 4.4 0.041 13.4 4.4 1.2 1 0 0 1 1 1 0 LRRFIP family DUF4795 PF16043.5 KOG98693.1 - 0.032 13.8 6.8 2.9 7.4 7.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) UPF0184 PF03670.13 KOG98693.1 - 0.052 13.9 1.0 0.052 13.9 1.0 2.0 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0184) DUF1664 PF07889.12 KOG98693.1 - 0.057 13.5 2.2 0.73 9.9 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Com_YlbF PF06133.11 KOG98693.1 - 0.085 13.5 5.9 0.1 13.2 1.2 2.5 3 0 0 3 3 2 0 Control of competence regulator ComK, YlbF/YmcA DUF5617 PF18493.1 KOG98693.1 - 0.099 12.8 0.3 1.5 9.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5617) DASH_Dad1 PF08649.10 KOG98693.1 - 0.12 12.6 1.0 2.1 8.6 1.0 2.6 2 1 0 2 2 2 0 DASH complex subunit Dad1 Cdh1_DBD_1 PF18196.1 KOG98693.1 - 0.14 12.5 4.5 0.28 11.5 0.8 2.2 1 1 1 2 2 2 0 Chromodomain helicase DNA-binding domain 1 Occludin_ELL PF07303.13 KOG98693.1 - 0.28 11.9 3.2 0.86 10.4 0.3 2.4 2 1 0 2 2 2 0 Occludin homology domain HetR_C PF18460.1 KOG98693.1 - 0.31 11.0 3.8 0.38 10.7 0.1 2.6 3 1 0 3 3 3 0 Heterocyst differentiation regulator C-terminal Hood domain CR6_interact PF10147.9 KOG98693.1 - 0.37 10.5 4.2 1.4 8.6 0.4 2.1 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 V-SNARE PF05008.15 KOG98693.1 - 0.52 10.7 8.9 1.1 9.7 1.6 2.7 3 0 0 3 3 2 0 Vesicle transport v-SNARE protein N-terminus Fungal_TACC PF12709.7 KOG98693.1 - 0.97 9.9 6.1 0.18 12.3 1.3 2.2 3 0 0 3 3 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins DMPK_coil PF08826.10 KOG98693.1 - 1.1 9.5 10.8 0.062 13.4 2.5 2.8 3 0 0 3 3 3 0 DMPK coiled coil domain like Snapin_Pallidin PF14712.6 KOG98693.1 - 1.4 9.3 6.2 1.3 9.4 0.7 2.9 2 1 1 3 3 3 0 Snapin/Pallidin DUF16 PF01519.16 KOG98693.1 - 3.7 8.1 7.0 17 6.0 6.5 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 MobC PF05713.11 KOG98693.1 - 4.9 7.7 7.1 3.2 8.3 0.1 3.5 3 1 1 4 4 3 0 Bacterial mobilisation protein (MobC) DivIC PF04977.15 KOG98693.1 - 7.1 6.5 8.8 0.36 10.6 1.3 2.5 3 0 0 3 3 3 0 Septum formation initiator VanZ PF04892.12 KOG98694.1 - 5.5e-09 36.8 0.3 6e-09 36.6 0.3 1.0 1 0 0 1 1 1 1 VanZ like family Cation_ATPase_C PF00689.21 KOG98694.1 - 0.05 13.3 0.4 0.059 13.1 0.4 1.1 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus SpoIID PF08486.10 KOG98694.1 - 0.053 14.1 0.0 0.062 13.9 0.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein Ribosomal_S7 PF00177.21 KOG98695.1 - 3e-34 117.8 0.1 4.6e-34 117.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e TRAM_LAG1_CLN8 PF03798.16 KOG98697.1 - 5.3e-32 111.2 17.5 5.3e-32 111.2 17.5 1.4 2 0 0 2 2 2 1 TLC domain Peptidase_M48_N PF16491.5 KOG98698.1 - 9.9e-61 204.8 12.5 9.9e-61 204.8 12.5 2.1 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 KOG98698.1 - 9.8e-47 159.3 0.0 1.7e-46 158.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 KOG98698.1 - 0.0087 15.3 0.2 0.021 14.0 0.2 1.6 1 0 0 1 1 1 1 BlaR1 peptidase M56 DUF2268 PF10026.9 KOG98698.1 - 0.014 15.0 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) SprT-like PF10263.9 KOG98698.1 - 0.025 14.4 0.1 0.048 13.5 0.1 1.4 1 0 0 1 1 1 0 SprT-like family DUF4157 PF13699.6 KOG98698.1 - 0.047 13.9 0.0 0.086 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4157) Ilm1 PF10311.9 KOG98699.1 - 1.1e-14 54.4 8.3 4e-12 46.1 8.3 2.1 1 1 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 CTP_transf_1 PF01148.20 KOG98699.1 - 0.52 10.0 3.6 0.76 9.5 3.6 1.2 1 0 0 1 1 1 0 Cytidylyltransferase family JmjC PF02373.22 KOG98700.1 - 4.5e-41 139.9 0.2 1.1e-40 138.6 0.2 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 KOG98700.1 - 3.9e-12 45.9 4.0 3.9e-12 45.9 4.0 2.4 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.17 KOG98700.1 - 2.9e-10 39.9 0.3 8.6e-10 38.4 0.3 1.9 1 0 0 1 1 1 1 jmjN domain E7 PF00527.18 KOG98700.1 - 0.1 12.8 1.5 0.62 10.3 0.3 2.5 2 0 0 2 2 2 0 E7 protein, Early protein zf-HC5HC2H PF13771.6 KOG98700.1 - 0.1 12.8 0.1 0.1 12.8 0.1 2.5 2 1 0 2 2 2 0 PHD-like zinc-binding domain Zf_RING PF16744.5 KOG98700.1 - 0.23 11.6 2.2 0.82 9.8 2.2 2.0 1 0 0 1 1 1 0 KIAA1045 RING finger PHD_2 PF13831.6 KOG98700.1 - 0.4 10.3 4.4 0.44 10.1 0.4 2.6 2 0 0 2 2 2 0 PHD-finger Prim_Zn_Ribbon PF08273.12 KOG98700.1 - 1.5 9.2 4.8 2.9 8.3 0.0 2.8 3 0 0 3 3 3 0 Zinc-binding domain of primase-helicase ATP-synt_ab PF00006.25 KOG98701.1 - 2.8e-62 210.1 0.0 4.8e-62 209.4 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KOG98701.1 - 8.6e-24 83.9 0.8 2.4e-23 82.4 0.8 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 KOG98701.1 - 0.0017 17.7 0.2 0.0028 17.0 0.2 1.4 1 0 0 1 1 1 1 KaiC NB-ARC PF00931.22 KOG98701.1 - 0.011 15.0 0.8 0.078 12.2 0.1 2.1 2 0 0 2 2 2 0 NB-ARC domain T3SS_ATPase_C PF18269.1 KOG98701.1 - 0.02 14.8 0.5 0.12 12.2 0.5 2.2 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain RsgA_GTPase PF03193.16 KOG98701.1 - 0.039 13.9 0.1 0.088 12.7 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA PF00004.29 KOG98701.1 - 0.042 14.3 0.1 0.63 10.5 0.0 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KOG98701.1 - 0.042 13.8 0.2 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.6 KOG98701.1 - 0.07 13.5 0.1 0.28 11.6 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.6 KOG98701.1 - 0.087 13.2 1.0 0.49 10.7 0.2 2.3 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KOG98701.1 - 0.11 12.9 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase RnfC_N PF13375.6 KOG98701.1 - 0.16 11.9 0.3 0.75 9.8 0.1 2.2 2 1 1 3 3 3 0 RnfC Barrel sandwich hybrid domain Pox_A32 PF04665.12 KOG98701.1 - 0.26 10.7 0.1 0.51 9.8 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein Ribosomal_S7 PF00177.21 KOG98703.1 - 1.5e-37 128.5 2.1 2.2e-37 128.0 2.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e MFS_1 PF07690.16 KOG98704.1 - 3.5e-25 88.7 21.5 8.6e-18 64.4 17.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG98704.1 - 9.3e-05 21.5 19.5 0.00083 18.3 19.5 2.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 KOG98704.1 - 0.0018 17.2 17.5 0.0086 15.0 14.9 2.5 1 1 1 2 2 2 2 MFS_1 like family OATP PF03137.20 KOG98704.1 - 0.0034 15.7 9.2 0.038 12.3 1.8 3.1 3 0 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.6 KOG98704.1 - 0.025 13.2 33.2 0.019 13.5 13.3 3.6 2 2 2 4 4 4 0 MFS/sugar transport protein ENTH PF01417.20 KOG98705.1 - 1.9e-44 150.7 0.1 3.8e-44 149.7 0.1 1.5 1 0 0 1 1 1 1 ENTH domain VHS PF00790.19 KOG98705.1 - 0.00035 20.4 0.0 0.00057 19.7 0.0 1.3 1 0 0 1 1 1 1 VHS domain ANTH PF07651.16 KOG98705.1 - 0.0011 18.1 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 ANTH domain Peptidase_M28 PF04389.17 KOG98706.1 - 6.3e-13 48.9 0.0 1.4e-12 47.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.15 KOG98706.1 - 2.8e-10 40.3 0.0 7.4e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.22 KOG98706.1 - 2.9e-06 27.2 0.0 7.3e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 PA domain zf-C2H2 PF00096.26 KOG98707.1 - 5.8e-05 23.3 13.5 0.005 17.2 4.6 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOG98707.1 - 8.8e-05 22.8 11.4 0.0028 18.0 6.7 2.7 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOG98707.1 - 0.0058 17.4 13.0 0.59 11.1 3.8 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger Methyltransf_16 PF10294.9 KOG98708.1 - 6.7e-24 84.6 0.0 1e-23 84.0 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 KOG98708.1 - 7.1e-06 25.9 0.0 1.2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOG98708.1 - 0.012 16.3 0.0 0.025 15.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 KOG98708.1 - 0.015 15.1 0.0 0.03 14.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 KOG98708.1 - 0.017 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 KOG98708.1 - 0.026 13.6 0.0 0.042 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_12 PF08242.12 KOG98708.1 - 0.039 14.7 0.0 0.07 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KOG98708.1 - 0.076 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Cys_Met_Meta_PP PF01053.20 KOG98709.1 - 3.4e-25 88.4 0.0 7.5e-25 87.3 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KOG98709.1 - 0.048 12.8 0.0 0.081 12.1 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II PDE6_gamma PF04868.12 KOG98709.1 - 0.086 13.1 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Retinal cGMP phosphodiesterase, gamma subunit Glyco_hydro_47 PF01532.20 KOG98710.1 - 1.7e-147 492.1 0.7 1.9e-147 491.9 0.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 IBN_N PF03810.19 KOG98711.1 - 1.5e-17 63.3 0.0 4.3e-16 58.6 0.0 3.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain Pribosyltran PF00156.27 KOG98712.1 - 6.2e-10 38.8 0.0 8.4e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain TMF_TATA_bd PF12325.8 KOG98713.1 - 1.3e-32 112.4 18.9 1.3e-32 112.4 18.9 6.2 3 2 1 4 4 4 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 KOG98713.1 - 1.6e-17 63.2 4.8 1.6e-17 63.2 4.8 9.7 5 3 5 10 10 10 1 TATA element modulatory factor 1 DNA binding BST2 PF16716.5 KOG98713.1 - 0.00033 21.2 8.4 0.00033 21.2 8.4 7.3 4 3 2 6 6 6 2 Bone marrow stromal antigen 2 Lebercilin PF15619.6 KOG98713.1 - 0.0005 19.8 18.1 0.0005 19.8 18.1 4.3 3 1 0 3 3 3 1 Ciliary protein causing Leber congenital amaurosis disease DUF812 PF05667.11 KOG98713.1 - 0.00059 18.9 27.3 0.00059 18.9 27.3 3.2 1 1 1 3 3 3 1 Protein of unknown function (DUF812) LPP PF04728.13 KOG98713.1 - 0.12 12.8 35.7 7 7.1 0.8 8.5 7 1 0 7 7 7 0 Lipoprotein leucine-zipper DUF4407 PF14362.6 KOG98713.1 - 2.7 7.3 52.2 0.016 14.6 3.5 4.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) zf-Tim10_DDP PF02953.15 KOG98715.1 - 5.5e-22 77.2 1.9 6.9e-22 76.9 1.9 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Tti2 PF10521.9 KOG98716.1 - 1.5e-61 208.4 4.2 1.5e-61 208.4 4.2 1.5 2 0 0 2 2 2 1 Tti2 family NIR_SIR PF01077.22 KOG98717.1 - 1.8e-58 196.6 0.0 9.3e-56 187.7 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain Flavodoxin_1 PF00258.25 KOG98717.1 - 1.1e-30 106.8 0.1 2.2e-30 105.7 0.1 1.6 1 0 0 1 1 1 1 Flavodoxin NIR_SIR_ferr PF03460.17 KOG98717.1 - 1.2e-27 95.6 0.1 1.6e-12 47.1 0.0 2.5 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Imm50 PF15594.6 KOG98717.1 - 0.098 12.9 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Immunity protein 50 IML1 PF12257.8 KOG98718.1 - 7.7e-105 350.1 1.5 1.3e-104 349.3 1.5 1.4 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 KOG98718.1 - 2.4e-24 85.1 0.7 6.6e-24 83.8 0.7 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Homoserine_dh PF00742.19 KOG98719.1 - 1.1e-52 178.5 0.1 1.5e-52 178.0 0.1 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 KOG98719.1 - 3.5e-29 101.8 0.0 9.9e-29 100.4 0.0 1.7 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain 6PF2K PF01591.18 KOG98719.1 - 0.053 12.8 0.1 0.09 12.1 0.1 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Dsh_C PF12316.8 KOG98720.1 - 3 8.2 5.6 0.88 9.9 0.2 2.2 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal HECT_2 PF09814.9 KOG98721.1 - 4.7e-70 236.3 0.1 5.3e-70 236.2 0.1 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding DUF4743 PF15916.5 KOG98722.1 - 9.7e-09 35.2 0.0 1.5e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) NUDIX PF00293.28 KOG98722.1 - 2.1e-07 31.0 0.0 4.5e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 NUDIX domain PMT PF02366.18 KOG98723.1 - 5e-87 291.6 21.0 9.1e-87 290.7 21.0 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 KOG98723.1 - 1.7e-63 213.9 7.2 1.7e-63 213.9 7.2 3.9 3 1 1 4 4 4 2 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 KOG98723.1 - 6.1e-24 84.9 0.2 1.1e-23 84.1 0.2 1.3 1 0 0 1 1 1 1 MIR domain PHO4 PF01384.20 KOG98723.1 - 0.037 13.1 0.4 0.17 10.9 0.1 2.0 2 0 0 2 2 2 0 Phosphate transporter family Mgm101p PF06420.12 KOG98724.1 - 4.8e-87 289.8 0.0 6.6e-87 289.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Ribosomal_S4e PF00900.20 KOG98725.1 - 6.6e-40 134.9 0.7 3.7e-38 129.3 0.5 2.3 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 KOG98725.1 - 1.3e-26 91.9 0.1 2.7e-26 91.0 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus KOW PF00467.29 KOG98725.1 - 2.7e-06 27.1 1.8 2.7e-06 27.1 1.8 3.2 4 0 0 4 4 4 1 KOW motif S4 PF01479.25 KOG98725.1 - 0.00016 21.3 0.2 0.00038 20.1 0.0 1.8 2 0 0 2 2 2 1 S4 domain Sipho_tail PF05709.11 KOG98725.1 - 0.052 13.0 0.1 0.1 12.0 0.1 1.6 1 1 0 1 1 1 0 Phage tail protein dCache_2 PF08269.11 KOG98725.1 - 0.15 11.3 0.0 0.29 10.3 0.0 1.5 1 1 0 1 1 1 0 Cache domain HSF_DNA-bind PF00447.17 KOG98726.1 - 4.2e-17 62.5 3.0 4.2e-17 62.5 3.0 2.1 2 0 0 2 2 2 1 HSF-type DNA-binding SUIM_assoc PF16619.5 KOG98726.1 - 0.019 15.0 2.1 0.038 14.0 2.1 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Aminotran_4 PF01063.19 KOG98727.1 - 3.8e-35 121.8 0.0 4.8e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV SRP1_TIP1 PF00660.17 KOG98728.1 - 1.6e-25 89.0 0.1 5.3e-25 87.4 0.1 1.9 1 0 0 1 1 1 1 Seripauperin and TIP1 family MFS_1 PF07690.16 KOG98729.1 - 5.7e-24 84.7 12.4 5.7e-24 84.7 12.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily NMO PF03060.15 KOG98730.1 - 1.4e-40 139.8 0.0 1.4e-39 136.4 0.0 2.0 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 KOG98730.1 - 5.2e-09 35.6 0.1 0.00092 18.3 0.0 2.5 2 1 1 3 3 3 2 IMP dehydrogenase / GMP reductase domain MFS_1 PF07690.16 KOG98731.1 - 6.4e-31 107.6 25.0 6.4e-31 107.6 25.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Pox_A14 PF05767.12 KOG98731.1 - 0.54 10.5 7.2 5 7.4 1.2 3.5 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 Glyco_hydro_28 PF00295.17 KOG98732.1 - 1e-108 363.3 22.1 1.1e-108 363.1 22.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Melibiase_2 PF16499.5 KOG98733.1 - 5.1e-60 203.1 8.3 7e-59 199.3 8.3 2.2 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 KOG98733.1 - 2.4e-11 43.5 2.7 3.8e-09 36.5 1.3 2.8 2 1 0 3 3 3 2 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 KOG98733.1 - 3.6e-06 26.2 0.1 1.6e-05 24.1 0.1 1.8 2 0 0 2 2 2 1 Melibiase FAD_binding_8 PF08022.12 KOG98734.1 - 3.6e-28 97.8 0.0 9.4e-28 96.5 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 KOG98734.1 - 7.3e-27 94.4 0.0 1.1e-26 93.8 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 KOG98734.1 - 1.2e-24 86.8 16.0 1.2e-24 86.8 16.0 2.1 3 0 0 3 3 3 1 Ferric reductase like transmembrane component Aldose_epim PF01263.20 KOG98735.1 - 4.2e-79 266.0 0.1 4.8e-79 265.8 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase ADH_zinc_N PF00107.26 KOG98736.1 - 2.9e-27 95.2 0.8 2.9e-27 95.2 0.8 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOG98736.1 - 1.8e-17 63.2 0.4 6.6e-17 61.4 0.0 2.1 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 KOG98736.1 - 1.9e-09 37.3 0.6 3.1e-09 36.6 0.6 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 KOG98736.1 - 5.5e-07 30.7 0.0 1.2e-06 29.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 KOG98736.1 - 3.3e-05 23.3 0.4 5.2e-05 22.6 0.4 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 KOG98736.1 - 0.0043 16.6 0.0 0.0082 15.7 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.14 KOG98736.1 - 0.0057 15.9 0.4 0.026 13.7 0.4 2.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 KOG98736.1 - 0.014 15.7 0.4 0.027 14.7 0.4 1.5 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 KOG98736.1 - 0.015 15.3 0.0 0.024 14.7 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 KOG98736.1 - 0.095 12.0 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Amidase PF01425.21 KOG98737.1 - 2.6e-72 244.2 0.0 1.5e-69 235.1 0.0 2.1 2 0 0 2 2 2 2 Amidase Asp PF00026.23 KOG98738.1 - 3.4e-57 194.2 6.9 4.4e-57 193.9 6.9 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOG98738.1 - 3.2e-10 40.5 3.4 8.4e-10 39.2 3.4 1.8 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 KOG98738.1 - 3.4e-06 27.6 0.2 0.41 11.3 0.0 3.5 3 0 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 KOG98738.1 - 7.6e-06 26.4 0.1 1.8 9.2 0.0 3.4 3 0 0 3 3 3 3 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 KOG98738.1 - 0.027 14.2 0.1 0.057 13.2 0.1 1.6 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal Aldo_ket_red PF00248.21 KOG98739.1 - 7.1e-48 163.3 0.0 7.8e-48 163.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF4214 PF13946.6 KOG98739.1 - 0.068 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4214) MFS_1 PF07690.16 KOG98740.1 - 2.9e-28 98.8 14.2 3.7e-28 98.5 14.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Fanconi_C PF02106.15 KOG98740.1 - 0.098 11.3 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 Fanconi anaemia group C protein CN_hydrolase PF00795.22 KOG98741.1 - 4.5e-46 157.3 0.0 5.4e-46 157.0 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Glyco_hydro_32N PF00251.20 KOG98742.1 - 7.5e-90 301.6 13.1 1.1e-89 301.1 13.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 KOG98742.1 - 5.4e-15 55.7 0.8 1e-14 54.8 0.8 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal RWD PF05773.22 KOG98743.1 - 0.035 14.4 1.5 0.06 13.6 0.8 1.8 1 1 0 1 1 1 0 RWD domain Presenilin PF01080.17 KOG98743.1 - 0.042 12.6 8.4 0.046 12.5 8.4 1.1 1 0 0 1 1 1 0 Presenilin LAP1C PF05609.12 KOG98743.1 - 1.3 8.1 11.2 1.8 7.6 11.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) XRN_M PF17846.1 KOG98743.1 - 1.4 7.8 12.7 2 7.3 12.7 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Zip PF02535.22 KOG98743.1 - 1.5 7.9 4.9 1.8 7.7 4.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Thiolase_N PF00108.23 KOG98744.1 - 2.9e-82 275.9 0.0 3.9e-82 275.5 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KOG98744.1 - 5.6e-50 168.1 0.3 1e-49 167.3 0.3 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KOG98744.1 - 0.00027 20.6 0.7 0.00062 19.4 0.1 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain FH2 PF02181.23 KOG98745.1 - 5.2e-79 266.0 16.2 5.2e-79 266.0 16.2 2.2 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 KOG98745.1 - 8.2e-06 25.5 1.2 8.2e-06 25.5 1.2 3.3 3 1 0 3 3 3 1 Diaphanous GTPase-binding Domain SKG6 PF08693.10 KOG98746.1 - 0.00079 18.8 0.4 0.0021 17.4 0.4 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Coa1 PF08695.10 KOG98747.1 - 1.3e-38 131.3 0.0 1.8e-38 130.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 lci PF12197.8 KOG98747.1 - 0.3 10.9 1.5 1.3 8.8 0.3 2.1 2 0 0 2 2 2 0 Bacillus cereus group antimicrobial protein DUF1748 PF08520.10 KOG98748.1 - 5.8e-11 42.1 0.3 6e-11 42.1 0.3 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) UCH PF00443.29 KOG98749.1 - 5.2e-64 216.2 3.3 5.2e-64 216.2 3.3 2.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOG98749.1 - 7.8e-21 75.0 0.9 7.8e-21 75.0 0.9 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Jiraiya PF15038.6 KOG98749.1 - 0.068 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Jiraiya Rubredoxin_2 PF18073.1 KOG98749.1 - 3.1 7.6 4.3 27 4.6 0.6 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain DAO PF01266.24 KOG98750.1 - 1.4e-57 195.9 0.0 2.3e-57 195.2 0.0 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 KOG98750.1 - 1e-38 132.0 0.0 2.1e-38 131.0 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 KOG98750.1 - 3.5e-13 49.4 1.9 2.2e-07 30.3 1.1 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 KOG98750.1 - 2.8e-08 33.6 0.3 1.7e-06 27.7 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOG98750.1 - 6.3e-06 25.6 1.3 4.3e-05 22.9 1.3 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOG98750.1 - 4.9e-05 22.6 3.9 0.0041 16.2 0.7 2.6 3 0 0 3 3 3 2 Glucose inhibited division protein A HI0933_like PF03486.14 KOG98750.1 - 0.00022 20.1 0.6 0.00037 19.3 0.6 1.3 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 KOG98750.1 - 0.00022 21.4 0.7 0.00082 19.6 0.3 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KOG98750.1 - 0.0016 17.7 0.3 0.0072 15.6 0.2 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOG98750.1 - 0.0019 17.5 0.0 0.13 11.5 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 KOG98750.1 - 0.012 14.9 0.1 0.087 12.0 0.0 2.1 2 0 0 2 2 2 0 Thi4 family GMC_oxred_N PF00732.19 KOG98750.1 - 0.021 14.2 0.1 0.076 12.4 0.0 1.8 2 0 0 2 2 2 0 GMC oxidoreductase Lycopene_cycl PF05834.12 KOG98750.1 - 0.032 13.3 0.6 0.33 9.9 0.1 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein 3HCDH_N PF02737.18 KOG98750.1 - 0.17 11.7 1.1 0.47 10.3 0.6 1.8 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DNA_pol_phi PF04931.13 KOG98751.1 - 0.12 10.5 13.6 0.15 10.1 13.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2722 PF10846.8 KOG98751.1 - 1.1 8.2 5.6 1.5 7.7 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Cwf_Cwc_15 PF04889.12 KOG98751.1 - 1.5 8.5 16.6 2.2 8.0 16.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PTPA PF03095.15 KOG98752.1 - 6.9e-102 340.9 0.0 8.2e-102 340.7 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein PIN_4 PF13638.6 KOG98754.1 - 2.9e-11 43.8 1.3 6.2e-11 42.7 1.3 1.6 1 0 0 1 1 1 1 PIN domain DUF1198 PF06711.11 KOG98754.1 - 0.035 14.2 0.4 0.25 11.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1198) zf-primase PF09329.11 KOG98755.1 - 5.9e-14 51.6 1.5 1.1e-13 50.8 1.5 1.5 1 0 0 1 1 1 1 Primase zinc finger DUF5088 PF17008.5 KOG98755.1 - 0.013 15.3 0.1 0.023 14.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5088) HBM PF16591.5 KOG98755.1 - 0.06 12.8 6.7 0.012 15.0 3.3 1.5 2 0 0 2 2 2 0 Helical bimodular sensor domain tRNA_anti-codon PF01336.25 KOG98755.1 - 0.15 12.1 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain NTS_2 PF15448.6 KOG98756.1 - 0.68 10.4 3.2 49 4.4 0.2 4.5 3 0 0 3 3 3 0 N-terminal segments of P. falciparum erythrocyte membrane protein ubiquitin PF00240.23 KOG98757.1 - 3.3e-33 113.3 0.5 4.5e-33 112.8 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 KOG98757.1 - 7.3e-31 105.8 10.9 1.1e-30 105.3 10.9 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 KOG98757.1 - 1.3e-14 53.8 0.3 2e-14 53.2 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KOG98757.1 - 3.1e-05 24.3 0.1 0.00012 22.5 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 KOG98757.1 - 0.0046 16.8 0.0 0.0065 16.4 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 KOG98757.1 - 0.0047 17.2 0.0 0.0071 16.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 KOG98757.1 - 0.0081 16.3 0.1 0.017 15.3 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 KOG98757.1 - 0.028 15.0 0.1 0.033 14.7 0.1 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 KOG98757.1 - 0.15 12.1 0.7 8.1 6.6 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain Response_reg PF00072.24 KOG98758.1 - 5.9e-29 100.5 0.5 2.8e-28 98.3 0.2 2.3 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.26 KOG98758.1 - 2.5e-27 95.6 1.4 2.8e-20 72.9 0.1 2.7 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 KOG98758.1 - 1.8e-11 43.9 0.2 5.5e-11 42.4 0.2 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 KOG98758.1 - 0.0031 17.8 0.9 0.26 11.7 0.1 2.5 2 0 0 2 2 2 1 HAMP domain Neuropeptide_S PF14993.6 KOG98758.1 - 0.16 11.8 0.8 0.48 10.3 0.8 1.8 1 0 0 1 1 1 0 Neuropeptide S precursor protein ArsP_1 PF03773.13 KOG98759.1 - 0.0026 16.9 0.0 0.004 16.4 0.0 1.2 1 0 0 1 1 1 1 Predicted permease DUF4449 PF14613.6 KOG98759.1 - 0.0048 17.0 3.7 0.0087 16.2 3.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4449) CDC45 PF02724.14 KOG98759.1 - 0.014 13.7 0.1 0.022 13.1 0.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 KOG98759.1 - 0.041 13.6 0.2 0.25 11.1 0.3 1.9 2 0 0 2 2 2 0 Connexin DUF4337 PF14235.6 KOG98759.1 - 0.11 12.6 0.1 0.18 11.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) 7tm_6 PF02949.20 KOG98759.1 - 0.42 9.6 1.6 1 8.4 0.0 2.1 2 1 1 3 3 3 0 7tm Odorant receptor Med19 PF10278.9 KOG98759.1 - 2.8 7.9 9.9 5.3 6.9 9.9 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Pantoate_ligase PF02569.15 KOG98760.1 - 1.1e-92 310.0 0.0 1.3e-92 309.8 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Ndc80_HEC PF03801.13 KOG98761.1 - 1.6e-51 173.9 9.2 3.5e-51 172.9 0.6 3.1 2 1 1 3 3 3 1 HEC/Ndc80p family DUF5595 PF18077.1 KOG98761.1 - 7e-12 45.2 4.4 7e-12 45.2 4.4 5.4 5 1 0 6 6 6 1 Domain of unknown function (DUF5595) CENP-F_leu_zip PF10473.9 KOG98761.1 - 0.00018 21.5 14.5 0.00018 21.5 14.5 3.8 3 2 1 4 4 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 KOG98761.1 - 0.0034 16.3 14.0 0.0034 16.3 14.0 3.0 3 1 0 3 3 3 1 Spc7 kinetochore protein YqbF PF14553.6 KOG98761.1 - 0.012 15.5 1.9 0.88 9.5 0.4 3.1 2 0 0 2 2 2 0 YqbF, hypothetical protein domain PSII_Pbs27 PF13326.6 KOG98761.1 - 0.017 15.4 8.4 0.071 13.4 4.0 2.7 2 0 0 2 2 2 0 Photosystem II Pbs27 DUF3130 PF11328.8 KOG98761.1 - 0.033 14.4 2.1 2.1 8.6 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3130 MbeD_MobD PF04899.12 KOG98761.1 - 0.67 10.1 6.7 1.1 9.5 0.2 3.5 3 0 0 3 3 3 0 MbeD/MobD like DUF4407 PF14362.6 KOG98761.1 - 1.1 8.5 15.1 0.12 11.7 5.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) UPF0160 PF03690.13 KOG98761.1 - 1.1 8.8 14.3 0.087 12.5 4.8 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0160) ATG16 PF08614.11 KOG98761.1 - 2.9 8.1 35.1 0.28 11.4 7.1 3.4 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) ERCC3_RAD25_C PF16203.5 KOG98762.1 - 2.1e-125 416.9 0.6 3.7e-125 416.1 0.6 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 KOG98762.1 - 1.7e-35 121.9 0.0 4.2e-35 120.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG98762.1 - 3.4e-16 59.7 0.0 8.4e-16 58.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOG98762.1 - 5.4e-12 46.0 0.1 1.4e-11 44.7 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 KOG98762.1 - 2.4e-09 36.4 0.0 2.9e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 KOG98762.1 - 2.2e-05 24.3 0.1 5.9e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase SBP_bac_6 PF13343.6 KOG98762.1 - 0.022 14.2 0.1 0.29 10.5 0.0 2.4 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein Cas_Csm6 PF09659.10 KOG98762.1 - 0.16 10.7 1.4 3 6.5 0.7 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csm6) Cpn60_TCP1 PF00118.24 KOG98763.1 - 1.1e-145 486.1 10.5 1.2e-145 485.9 10.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRM1_repeat PF18777.1 KOG98763.1 - 0.17 11.4 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat SKG6 PF08693.10 KOG98764.1 - 1.6e-15 56.2 2.7 3.7e-15 55.1 2.7 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain He_PIG PF05345.12 KOG98764.1 - 7.6e-12 45.2 3.5 6.3e-05 23.1 0.0 5.1 4 1 0 4 4 4 2 Putative Ig domain TMEM154 PF15102.6 KOG98764.1 - 1.9e-06 27.8 1.7 1.9e-06 27.8 1.7 2.3 2 0 0 2 2 2 1 TMEM154 protein family RIFIN PF02009.16 KOG98764.1 - 3.2e-05 24.0 0.3 5.1e-05 23.3 0.3 1.3 1 0 0 1 1 1 1 Rifin MGC-24 PF05283.11 KOG98764.1 - 0.00012 22.6 4.5 0.00012 22.6 4.5 2.4 2 0 0 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin Mid2 PF04478.12 KOG98764.1 - 0.00019 21.3 3.7 0.00041 20.2 3.2 1.9 1 1 0 1 1 1 1 Mid2 like cell wall stress sensor Adeno_E3_CR2 PF02439.15 KOG98764.1 - 0.0022 17.7 0.2 0.0039 16.9 0.2 1.3 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 DUF4448 PF14610.6 KOG98764.1 - 0.0073 16.1 0.6 0.0073 16.1 0.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) Stevor PF17410.2 KOG98764.1 - 0.013 15.1 0.3 0.024 14.2 0.3 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame EphA2_TM PF14575.6 KOG98764.1 - 0.021 15.7 0.0 0.061 14.2 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Podoplanin PF05808.11 KOG98764.1 - 0.026 14.6 2.4 0.079 13.1 2.4 1.8 1 0 0 1 1 1 0 Podoplanin Orf78 PF06024.12 KOG98764.1 - 0.038 14.3 0.1 0.16 12.3 0.1 2.1 1 0 0 1 1 1 0 Orf78 (ac78) PTP_tm PF18861.1 KOG98764.1 - 0.05 13.6 0.1 0.13 12.2 0.1 1.7 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J TMEM51 PF15345.6 KOG98764.1 - 0.072 12.9 1.3 0.1 12.4 0.2 1.8 1 1 1 2 2 2 0 Transmembrane protein 51 DUF4010 PF13194.6 KOG98764.1 - 0.076 12.7 0.5 0.13 11.9 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) HORMA PF02301.18 KOG98765.1 - 4e-11 42.9 0.9 8.8e-11 41.8 0.9 1.5 1 1 0 1 1 1 1 HORMA domain Tropomyosin_1 PF12718.7 KOG98766.1 - 9.6e-47 158.7 39.1 1.1e-46 158.5 39.1 1.1 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 KOG98766.1 - 6.7e-07 28.9 36.1 0.0018 17.7 15.0 2.0 1 1 1 2 2 2 2 Tropomyosin Spc7 PF08317.11 KOG98766.1 - 0.00014 20.9 35.6 0.0055 15.6 13.0 2.1 1 1 1 2 2 2 2 Spc7 kinetochore protein KLRAQ PF10205.9 KOG98766.1 - 0.00023 21.3 27.7 0.012 15.9 11.7 2.1 1 1 1 2 2 2 2 Predicted coiled-coil domain-containing protein APG6_N PF17675.1 KOG98766.1 - 0.00027 21.5 45.1 0.071 13.6 23.1 2.0 1 1 1 2 2 2 2 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 KOG98766.1 - 0.00042 20.4 40.4 0.0099 15.9 10.3 2.3 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_DNA_bd PF12329.8 KOG98766.1 - 0.00063 19.7 43.3 0.0097 15.9 16.1 3.1 2 1 1 3 3 3 2 TATA element modulatory factor 1 DNA binding GAS PF13851.6 KOG98766.1 - 0.0011 18.3 37.4 0.071 12.5 33.5 3.1 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Laminin_II PF06009.12 KOG98766.1 - 0.0015 18.5 21.4 0.0024 17.9 9.0 2.5 1 1 1 2 2 2 1 Laminin Domain II ERM PF00769.19 KOG98766.1 - 0.002 18.0 36.8 0.011 15.6 18.7 2.0 1 1 1 2 2 2 1 Ezrin/radixin/moesin family ATG16 PF08614.11 KOG98766.1 - 0.0028 17.9 31.9 0.44 10.7 14.2 2.4 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) WXG100 PF06013.12 KOG98766.1 - 0.0046 17.2 15.9 0.15 12.3 0.1 3.8 2 1 1 3 3 3 1 Proteins of 100 residues with WXG BLOC1_2 PF10046.9 KOG98766.1 - 0.0058 16.9 26.6 0.36 11.1 6.1 3.5 1 1 3 4 4 4 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlaC_arch PF05377.11 KOG98766.1 - 0.0067 16.8 25.4 0.43 11.0 2.9 4.4 2 1 3 5 5 5 3 Flagella accessory protein C (FlaC) ADIP PF11559.8 KOG98766.1 - 0.008 16.3 30.7 0.51 10.4 9.6 2.8 1 1 1 2 2 2 2 Afadin- and alpha -actinin-Binding EzrA PF06160.12 KOG98766.1 - 0.013 13.8 31.3 0.35 9.0 13.6 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Taxilin PF09728.9 KOG98766.1 - 0.015 14.5 38.0 0.022 14.0 11.9 2.4 1 1 1 2 2 2 0 Myosin-like coiled-coil protein DUF3584 PF12128.8 KOG98766.1 - 0.015 12.9 30.8 0.017 12.7 30.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4795 PF16043.5 KOG98766.1 - 0.017 14.7 30.2 0.099 12.2 30.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Uds1 PF15456.6 KOG98766.1 - 0.02 15.0 25.0 0.051 13.7 10.6 2.4 1 1 1 2 2 2 0 Up-regulated During Septation Fib_alpha PF08702.10 KOG98766.1 - 0.029 14.5 23.1 0.14 12.3 10.7 3.0 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family MIS13 PF08202.11 KOG98766.1 - 0.03 13.6 28.3 1.4 8.1 19.1 2.3 1 1 1 2 2 2 0 Mis12-Mtw1 protein family DUF724 PF05266.14 KOG98766.1 - 0.036 13.9 30.6 0.4 10.5 12.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) TPR_MLP1_2 PF07926.12 KOG98766.1 - 0.043 13.9 42.0 3.6 7.7 8.7 2.9 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Uso1_p115_C PF04871.13 KOG98766.1 - 0.049 14.0 40.4 0.4 11.0 17.3 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Lectin_N PF03954.14 KOG98766.1 - 0.057 13.2 16.2 1.1 8.9 8.1 2.8 1 1 3 4 4 4 0 Hepatic lectin, N-terminal domain DUF1664 PF07889.12 KOG98766.1 - 0.058 13.4 16.9 0.25 11.4 5.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) SNARE PF05739.19 KOG98766.1 - 0.068 13.2 0.7 0.51 10.4 0.2 2.3 2 0 0 2 2 2 0 SNARE domain DUF3450 PF11932.8 KOG98766.1 - 0.07 12.4 29.4 0.13 11.6 11.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Filament PF00038.21 KOG98766.1 - 0.075 12.6 30.7 0.47 10.0 16.3 2.0 1 1 1 2 2 2 0 Intermediate filament protein YscO PF07321.12 KOG98766.1 - 0.076 13.0 29.5 1.4 8.9 1.6 3.1 1 1 2 3 3 3 0 Type III secretion protein YscO Fez1 PF06818.15 KOG98766.1 - 0.093 13.2 32.1 0.31 11.5 31.7 1.8 1 1 0 1 1 1 0 Fez1 Cast PF10174.9 KOG98766.1 - 0.11 10.7 30.2 0.14 10.4 30.2 1.1 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone Ax_dynein_light PF10211.9 KOG98766.1 - 0.13 12.2 37.5 0.073 13.0 4.5 3.1 1 1 2 3 3 3 0 Axonemal dynein light chain OmpH PF03938.14 KOG98766.1 - 0.17 12.2 36.0 0.07 13.5 17.8 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DHR10 PF18595.1 KOG98766.1 - 0.18 11.9 35.5 0.85 9.7 13.1 2.6 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF4200 PF13863.6 KOG98766.1 - 0.2 12.1 39.0 2 8.8 18.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) IFT57 PF10498.9 KOG98766.1 - 0.21 10.5 28.0 0.38 9.7 9.9 2.1 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 THOC7 PF05615.13 KOG98766.1 - 0.28 11.4 30.1 2.6 8.4 11.9 2.8 1 1 1 2 2 2 0 Tho complex subunit 7 Lebercilin PF15619.6 KOG98766.1 - 0.34 10.5 34.9 6.4 6.4 34.3 2.2 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease T2SSM PF04612.12 KOG98766.1 - 0.36 10.9 12.1 0.12 12.5 2.8 2.9 2 1 1 3 3 3 0 Type II secretion system (T2SS), protein M Atg14 PF10186.9 KOG98766.1 - 0.37 9.8 27.6 0.052 12.6 8.7 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Sec34 PF04136.15 KOG98766.1 - 0.41 10.5 22.2 1.3 8.9 4.5 2.6 1 1 2 3 3 3 0 Sec34-like family ZapB PF06005.12 KOG98766.1 - 0.5 10.8 42.4 0.72 10.3 14.1 3.9 2 1 1 3 3 3 0 Cell division protein ZapB BBP1_C PF15272.6 KOG98766.1 - 0.58 10.0 30.4 0.34 10.7 4.2 3.1 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal DUF3037 PF11236.8 KOG98766.1 - 0.66 10.4 7.0 0.53 10.7 0.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) RPW8 PF05659.11 KOG98766.1 - 0.8 9.4 15.5 0.13 11.9 7.3 2.8 1 1 2 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 FliD_C PF07195.12 KOG98766.1 - 0.84 9.0 20.1 3.1 7.1 0.3 2.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus MscS_porin PF12795.7 KOG98766.1 - 0.85 9.1 29.8 1.2 8.6 0.4 3.0 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain Exonuc_VII_S PF02609.16 KOG98766.1 - 0.87 9.7 20.6 0.67 10.1 0.9 3.9 4 0 0 4 4 3 0 Exonuclease VII small subunit KELK PF15796.5 KOG98766.1 - 0.91 10.0 37.7 0.23 12.0 3.7 4.1 1 1 3 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase XhlA PF10779.9 KOG98766.1 - 0.93 9.7 28.4 0.86 9.9 3.4 4.2 1 1 3 4 4 3 0 Haemolysin XhlA NPV_P10 PF05531.12 KOG98766.1 - 0.96 10.0 12.0 4e+03 -1.6 12.0 3.9 1 1 0 1 1 0 0 Nucleopolyhedrovirus P10 protein MbeD_MobD PF04899.12 KOG98766.1 - 1 9.5 13.7 0.39 10.9 0.9 3.2 1 1 2 3 3 3 0 MbeD/MobD like HIP1_clath_bdg PF16515.5 KOG98766.1 - 1.1 9.8 35.1 1.2 9.7 16.3 3.1 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cortex-I_coil PF09304.10 KOG98766.1 - 1.2 9.3 28.8 8.6 6.6 11.4 3.1 1 1 2 3 3 3 0 Cortexillin I, coiled coil T3SS_basalb_I PF17001.5 KOG98766.1 - 1.3 9.7 13.4 1.3 9.6 2.5 2.7 1 1 2 3 3 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI Spc24 PF08286.11 KOG98766.1 - 1.3 9.3 35.2 7 7.0 1.3 4.0 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 HTH_57 PF18679.1 KOG98766.1 - 1.4 9.2 8.7 0.65 10.3 1.5 2.2 1 1 1 2 2 2 0 ThcOx helix turn helix domain Phage_GP20 PF06810.11 KOG98766.1 - 1.5 8.7 33.1 9.2 6.1 24.8 2.8 1 1 1 2 2 2 0 Phage minor structural protein GP20 UPF0242 PF06785.11 KOG98766.1 - 1.5 8.9 39.0 11 6.1 19.2 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF812 PF05667.11 KOG98766.1 - 1.6 7.5 35.5 2 7.2 35.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF2353 PF09789.9 KOG98766.1 - 1.6 8.0 29.6 2.2 7.6 29.6 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) HAP1_N PF04849.13 KOG98766.1 - 1.6 7.8 35.3 1.8 7.7 35.3 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Rho_Binding PF08912.11 KOG98766.1 - 1.7 9.5 42.3 0.74 10.7 9.4 3.9 1 1 3 4 4 4 0 Rho Binding COG2 PF06148.11 KOG98766.1 - 1.8 8.6 19.1 3.6 7.7 4.9 2.7 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 RmuC PF02646.16 KOG98766.1 - 1.9 7.5 23.0 5.1 6.2 0.4 3.1 1 1 2 3 3 3 0 RmuC family HemX PF04375.14 KOG98766.1 - 2 7.7 24.8 4.4 6.5 18.7 2.1 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Seryl_tRNA_N PF02403.22 KOG98766.1 - 2 8.7 31.7 2.1 8.6 3.4 3.2 1 1 1 2 2 1 0 Seryl-tRNA synthetase N-terminal domain HOOK PF05622.12 KOG98766.1 - 2.1 6.4 35.5 0.27 9.3 25.1 1.9 1 1 1 2 2 2 0 HOOK protein ApoO PF09769.9 KOG98766.1 - 2.3 8.2 9.7 2.1 8.3 1.3 3.0 1 1 2 3 3 3 0 Apolipoprotein O FPP PF05911.11 KOG98766.1 - 2.3 6.3 33.7 3.5 5.7 33.7 1.3 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil DivIC PF04977.15 KOG98766.1 - 2.4 8.0 31.7 0.078 12.8 4.7 4.1 1 1 3 4 4 4 0 Septum formation initiator TMF_TATA_bd PF12325.8 KOG98766.1 - 2.6 8.3 33.6 5.1 7.4 2.0 3.3 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding YtxH PF12732.7 KOG98766.1 - 2.6 8.6 15.3 7.2e+03 -2.4 15.3 3.1 1 1 0 1 1 0 0 YtxH-like protein DUF16 PF01519.16 KOG98766.1 - 2.8 8.5 26.1 1.8 9.1 9.1 2.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 TolA_bind_tri PF16331.5 KOG98766.1 - 2.9 8.0 20.9 1.5 9.0 2.2 3.6 1 1 3 4 4 4 0 TolA binding protein trimerisation CC2-LZ PF16516.5 KOG98766.1 - 2.9 8.3 28.0 0.5 10.8 17.0 2.5 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Mod_r PF07200.13 KOG98766.1 - 2.9 8.0 36.1 20 5.3 23.7 3.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Swi5 PF07061.11 KOG98766.1 - 3.3 7.8 32.4 3.8 7.7 1.0 4.1 1 1 3 4 4 4 0 Swi5 DUF745 PF05335.13 KOG98766.1 - 3.5 7.3 21.3 1.2 8.8 5.9 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF745) Prefoldin_2 PF01920.20 KOG98766.1 - 3.8 7.5 40.1 4.3 7.3 3.1 4.1 1 1 3 4 4 4 0 Prefoldin subunit DUF4107 PF13389.6 KOG98766.1 - 3.8 7.6 7.9 3.1 7.9 5.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4107) Csm1_N PF18504.1 KOG98766.1 - 3.8 7.9 31.8 1.8 9.0 4.4 4.3 1 1 3 4 4 4 0 Csm1 N-terminal domain KfrA_N PF11740.8 KOG98766.1 - 4.1 8.1 22.9 5.3 7.8 2.5 3.5 1 1 2 3 3 3 0 Plasmid replication region DNA-binding N-term Baculo_PEP_C PF04513.12 KOG98766.1 - 4.2 7.4 9.9 1.5e+02 2.4 9.9 2.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_13 PF13166.6 KOG98766.1 - 4.4 5.8 28.7 0.89 8.1 10.6 1.9 1 1 0 1 1 1 0 AAA domain ZYG-11_interact PF05884.12 KOG98766.1 - 4.5 6.6 4.8 8.8 5.6 4.8 1.7 1 1 0 1 1 1 0 Interactor of ZYG-11 Herpes_UL6 PF01763.16 KOG98766.1 - 4.5 5.7 20.6 2.1 6.8 8.5 2.3 1 1 1 2 2 2 0 Herpesvirus UL6 like IZUMO PF15005.6 KOG98766.1 - 4.8 7.7 15.4 1.1 9.8 10.0 2.0 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated TMPIT PF07851.13 KOG98766.1 - 5.2 6.2 28.2 0.97 8.6 13.0 2.0 1 1 1 2 2 2 0 TMPIT-like protein PRKG1_interact PF15898.5 KOG98766.1 - 5.4 8.0 35.1 8.1 7.4 15.9 2.2 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Jnk-SapK_ap_N PF09744.9 KOG98766.1 - 5.6 7.2 39.3 28 4.9 13.1 2.8 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 HSP70 PF00012.20 KOG98766.1 - 5.8 5.0 22.4 6.7 4.8 22.4 1.2 1 0 0 1 1 1 0 Hsp70 protein DUF4407 PF14362.6 KOG98766.1 - 6.5 6.0 22.7 12 5.1 22.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Phage_GPO PF05929.11 KOG98766.1 - 6.8 6.2 21.1 2.3 7.8 14.8 2.0 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase FTO_CTD PF12934.7 KOG98766.1 - 7.2 6.3 14.6 9.3 6.0 4.2 2.2 1 1 1 2 2 2 0 FTO C-terminal domain Exonuc_VII_L PF02601.15 KOG98766.1 - 9.5 5.7 22.2 88 2.5 22.2 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_M1 PF01433.20 KOG98767.1 - 5.2e-63 212.5 0.4 1.3e-62 211.2 0.4 1.7 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 KOG98767.1 - 3.9e-41 141.3 2.1 3.9e-41 141.3 2.1 1.8 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 KOG98767.1 - 1.1e-37 130.3 0.0 1.6e-37 129.7 0.0 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain peroxidase PF00141.23 KOG98767.1 - 0.016 14.9 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 Peroxidase Aminopep PF10023.9 KOG98767.1 - 0.06 12.7 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative aminopeptidase MIT PF04212.18 KOG98768.1 - 0.03 14.4 1.0 0.03 14.4 1.0 3.1 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain DUF148 PF02520.17 KOG98768.1 - 0.086 13.0 5.4 0.14 12.3 0.7 2.9 3 0 0 3 3 3 0 Domain of unknown function DUF148 DUF1079 PF06435.11 KOG98768.1 - 0.14 12.3 2.0 13 6.1 0.3 3.0 2 0 0 2 2 2 0 Repeat of unknown function (DUF1079) TPR_2 PF07719.17 KOG98768.1 - 2.9 8.2 7.4 9 6.7 1.8 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Apolipoprotein PF01442.18 KOG98768.1 - 2.9 7.7 17.3 5.8 6.7 10.1 3.3 2 1 1 3 3 3 0 Apolipoprotein A1/A4/E domain Mito_carr PF00153.27 KOG98770.1 - 8.4e-64 211.5 3.4 6.3e-22 77.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SepA PF17080.5 KOG98770.1 - 0.069 13.5 0.1 0.16 12.3 0.1 1.6 1 0 0 1 1 1 0 Multidrug Resistance efflux pump CSM2 PF16834.5 KOG98772.1 - 5.7e-72 241.5 1.4 6.5e-72 241.4 1.4 1.0 1 0 0 1 1 1 1 Shu complex component Csm2, DNA-binding Forkhead PF00250.18 KOG98773.1 - 9.1e-32 109.2 0.3 2.4e-31 107.8 0.2 1.8 2 0 0 2 2 2 1 Forkhead domain FHA PF00498.26 KOG98773.1 - 7e-14 51.9 0.1 7.8e-13 48.6 0.0 2.5 2 0 0 2 2 2 1 FHA domain Linker_histone PF00538.19 KOG98773.1 - 0.0009 19.6 0.0 0.0019 18.5 0.0 1.6 1 0 0 1 1 1 1 linker histone H1 and H5 family UPF0524 PF15823.5 KOG98773.1 - 0.059 12.8 0.2 0.19 11.1 0.0 1.8 2 0 0 2 2 2 0 UPF0524 of C3orf70 Fungal_trans PF04082.18 KOG98774.1 - 1e-40 139.5 2.6 1e-40 139.5 2.6 3.1 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG98774.1 - 7.2e-11 42.0 12.8 1.2e-10 41.3 12.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF5558 PF17713.1 KOG98774.1 - 1.5 9.2 5.2 13 6.2 2.9 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5558) MOR2-PAG1_N PF14222.6 KOG98775.1 - 3.4e-179 597.4 8.1 6.2e-179 596.5 8.1 1.5 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 KOG98775.1 - 7.8e-90 301.1 3.9 2.4e-89 299.5 0.4 3.4 3 0 0 3 3 3 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 KOG98775.1 - 1.3e-22 79.4 18.9 1.7e-10 39.2 1.1 3.8 2 2 1 3 3 3 3 Cell morphogenesis central region Cnd1 PF12717.7 KOG98775.1 - 0.0044 17.1 3.3 0.082 12.9 0.2 3.6 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 DUF4259 PF14078.6 KOG98775.1 - 0.15 12.8 1.6 1.1 10.0 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4259) SDP_N PF12278.8 KOG98775.1 - 7.5 6.7 11.4 0.13 12.4 0.1 3.2 3 0 0 3 3 3 0 Sex determination protein N terminal MMS19_C PF12460.8 KOG98776.1 - 4.1e-92 309.5 20.2 4.1e-92 309.5 20.2 3.0 3 1 1 4 4 4 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 KOG98776.1 - 1.6e-83 280.3 13.1 2.8e-80 269.7 4.6 3.5 3 0 0 3 3 3 3 Dos2-interacting transcription regulator of RNA-Pol-II RTP1_C1 PF10363.9 KOG98776.1 - 7.9e-05 22.8 2.4 0.0071 16.5 0.2 3.2 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 KOG98776.1 - 0.00028 21.2 0.0 0.012 16.0 0.0 3.1 2 0 0 2 2 2 1 HEAT repeats HEAT_EZ PF13513.6 KOG98776.1 - 0.00054 20.4 3.8 0.58 10.7 0.1 4.1 4 0 0 4 4 4 2 HEAT-like repeat HEAT PF02985.22 KOG98776.1 - 0.0016 18.6 0.2 1.2 9.6 0.0 4.9 5 0 0 5 5 5 1 HEAT repeat Vac14_Fab1_bd PF12755.7 KOG98776.1 - 0.0034 17.9 0.4 0.78 10.4 0.0 4.1 2 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region RRT14 PF17075.5 KOG98777.1 - 1.4e-59 201.5 15.3 1.6e-59 201.3 15.3 1.0 1 0 0 1 1 1 1 Regular of rDNA transcription protein 14 DUF2207 PF09972.9 KOG98777.1 - 0.069 11.9 6.8 0.099 11.4 6.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SpoU_sub_bind PF08032.12 KOG98777.1 - 0.1 12.9 5.2 0.059 13.6 2.1 2.2 2 1 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding SNF2_N PF00176.23 KOG98778.1 - 7.9e-76 255.0 1.7 2.3e-75 253.5 1.7 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOG98778.1 - 6.1e-23 81.3 0.9 2.7e-20 72.8 0.0 3.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 KOG98778.1 - 2.9e-19 68.9 1.2 1e-18 67.1 0.3 2.5 2 0 0 2 2 2 1 Bromodomain ResIII PF04851.15 KOG98778.1 - 3.7e-11 43.3 0.1 3.7e-11 43.3 0.1 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SnAC PF14619.6 KOG98778.1 - 4.4e-10 40.0 4.0 1.1e-09 38.7 0.6 3.6 2 0 0 2 2 2 1 Snf2-ATP coupling, chromatin remodelling complex HSA PF07529.13 KOG98778.1 - 1.4e-08 35.0 9.8 1.4e-08 35.0 9.8 3.1 3 0 0 3 3 3 1 HSA Transket_pyr PF02779.24 KOG98779.1 - 7.8e-66 221.1 0.0 1.4e-65 220.3 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 KOG98779.1 - 8.4e-58 195.7 0.0 1.2e-57 195.1 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 KOG98779.1 - 2.5e-48 163.6 0.0 4.1e-48 162.9 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 KOG98779.1 - 1.2e-19 69.6 2.6 2.4e-19 68.6 2.6 1.6 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus adh_short PF00106.25 KOG98780.1 - 1.5e-46 158.3 0.0 2.5e-46 157.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOG98780.1 - 3.6e-27 95.4 0.0 4.5e-27 95.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOG98780.1 - 5.8e-06 26.3 0.0 8.8e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOG98780.1 - 8.4e-06 25.4 0.0 2.7e-05 23.8 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KOG98780.1 - 4.5e-05 22.7 0.0 6.4e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 KOG98780.1 - 0.0019 18.1 0.0 0.0033 17.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 KOG98780.1 - 0.021 15.1 0.0 0.05 13.9 0.0 1.5 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF1776 PF08643.10 KOG98780.1 - 0.028 13.8 0.0 8.8 5.6 0.0 2.8 2 1 0 2 2 2 0 Fungal family of unknown function (DUF1776) NmrA PF05368.13 KOG98780.1 - 0.12 11.9 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family GDP_Man_Dehyd PF16363.5 KOG98780.1 - 0.15 11.4 0.0 0.61 9.4 0.0 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase SUN PF03856.13 KOG98781.1 - 8.8e-98 326.6 11.9 1.2e-97 326.1 11.9 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) SPX PF03105.19 KOG98781.1 - 0.05 13.5 13.0 0.06 13.3 13.0 1.2 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 KOG98781.1 - 1.5 7.3 20.1 2.4 6.6 20.1 1.3 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 KOG98781.1 - 1.6 7.5 15.0 2.1 7.1 15.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain MFS_1 PF07690.16 KOG98783.1 - 3.5e-43 147.9 19.1 2.5e-37 128.6 13.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG98783.1 - 1.6e-06 27.3 14.7 1.6e-06 27.3 14.7 2.7 2 1 1 3 3 3 2 Sugar (and other) transporter Peptidase_M9_N PF08453.10 KOG98783.1 - 0.0033 17.2 0.0 0.0067 16.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M9 N-terminal Gly-zipper_Omp PF13488.6 KOG98783.1 - 0.64 10.1 4.0 1.5 8.9 4.0 1.6 1 0 0 1 1 1 0 Glycine zipper MFS_1 PF07690.16 KOG98784.1 - 1.6e-43 149.0 22.1 1.1e-39 136.4 14.0 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG98784.1 - 8.7e-12 44.6 24.0 9.3e-09 34.6 12.4 3.0 2 1 1 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 KOG98784.1 - 1.1e-05 24.1 5.0 1.1e-05 24.1 5.0 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 KOG98784.1 - 0.37 9.6 11.2 0.066 12.1 5.5 2.1 2 0 0 2 2 2 0 MFS_1 like family Myb_DNA-bind_4 PF13837.6 KOG98785.1 - 0.00015 22.1 8.3 0.00017 21.9 3.1 2.7 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain WD40_alt PF14077.6 KOG98785.1 - 0.15 12.0 0.9 0.37 10.7 0.1 2.0 2 0 0 2 2 2 0 Alternative WD40 repeat motif Ras PF00071.22 KOG98786.1 - 1.6e-59 200.1 0.1 2.1e-59 199.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG98786.1 - 3.6e-23 82.0 0.0 5.9e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG98786.1 - 4.7e-10 39.2 0.0 7.2e-10 38.6 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 KOG98786.1 - 0.00041 19.6 0.1 0.00049 19.4 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 KOG98786.1 - 0.00088 18.7 0.0 0.0011 18.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KOG98786.1 - 0.003 17.0 0.0 0.0039 16.6 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KOG98786.1 - 0.0036 17.4 0.0 0.0073 16.4 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 KOG98786.1 - 0.045 14.3 0.3 0.096 13.2 0.3 1.8 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 KOG98786.1 - 0.17 12.2 0.0 0.32 11.4 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain EphA2_TM PF14575.6 KOG98787.1 - 0.14 13.1 0.0 0.81 10.6 0.0 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain AJAP1_PANP_C PF15298.6 KOG98787.1 - 0.74 10.0 13.8 0.14 12.3 7.5 2.1 2 0 0 2 2 2 0 AJAP1/PANP C-terminus Aminotran_1_2 PF00155.21 KOG98788.1 - 7.3e-70 236.0 0.0 8.6e-70 235.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 KOG98788.1 - 0.0011 18.0 0.0 0.0016 17.4 0.0 1.3 1 0 0 1 1 1 1 Allinase NUP214 PF16755.5 KOG98789.1 - 2.8e-158 526.8 4.4 2.8e-158 526.8 4.4 2.1 2 1 0 2 2 2 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 DUF1040 PF06288.13 KOG98789.1 - 0.15 12.4 0.3 0.51 10.7 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1040) Porin_3 PF01459.22 KOG98790.1 - 2.5e-59 201.0 2.6 2.8e-59 200.8 2.6 1.0 1 0 0 1 1 1 1 Eukaryotic porin DSPc PF00782.20 KOG98791.1 - 1.7e-33 115.2 0.0 2.2e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOG98791.1 - 0.00029 20.5 0.0 0.0004 20.0 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KOG98791.1 - 0.011 15.8 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate CDKN3 PF05706.12 KOG98791.1 - 0.02 14.6 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Ank_4 PF13637.6 KOG98792.1 - 4.2e-32 110.1 0.2 6.2e-11 42.6 0.1 5.1 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOG98792.1 - 9.6e-32 109.4 0.0 1.4e-12 48.0 0.0 4.2 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOG98792.1 - 1.4e-29 101.8 0.0 3.1e-08 33.7 0.1 4.6 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KOG98792.1 - 2.3e-23 81.5 0.1 1.4e-06 28.5 0.1 6.4 6 1 1 7 7 7 4 Ankyrin repeat Ank_3 PF13606.6 KOG98792.1 - 1.2e-21 74.4 0.0 1.7e-07 31.0 0.1 5.2 5 0 0 5 5 5 4 Ankyrin repeat Sec23_trunk PF04811.15 KOG98794.1 - 2.4e-74 250.0 0.0 5.4e-74 248.8 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 KOG98794.1 - 7e-20 70.8 0.2 1.8e-19 69.5 0.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 KOG98794.1 - 4.3e-16 58.7 5.5 8.2e-16 57.8 5.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 KOG98794.1 - 1.1e-14 54.9 0.2 2.9e-14 53.6 0.2 1.8 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 KOG98794.1 - 6.2e-11 42.0 0.0 1.4e-10 40.9 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Metallopep PF12044.8 KOG98795.1 - 4.4e-175 582.4 0.0 5.3e-175 582.1 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.17 KOG98795.1 - 0.00015 21.7 0.3 0.00038 20.4 0.1 1.8 2 0 0 2 2 2 1 Jacalin-like lectin domain Reprolysin_3 PF13582.6 KOG98795.1 - 0.013 16.1 0.0 0.03 14.8 0.0 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KOG98795.1 - 0.032 14.4 0.0 0.056 13.6 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 KOG98795.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Matrixin Peptidase_M66 PF10462.9 KOG98795.1 - 0.21 10.5 0.6 0.51 9.2 0.1 1.7 2 0 0 2 2 2 0 Peptidase M66 6PF2K PF01591.18 KOG98796.1 - 3.3e-85 284.9 0.0 6.6e-85 283.9 0.0 1.5 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KOG98796.1 - 9.4e-30 103.8 0.0 5.8e-25 88.1 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 KOG98796.1 - 1.9e-06 28.1 0.0 5.4e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOG98796.1 - 0.0011 19.5 0.0 0.0057 17.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 KOG98796.1 - 0.018 14.9 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_17 PF13207.6 KOG98796.1 - 0.063 13.7 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Mob1_phocein PF03637.17 KOG98797.1 - 7.3e-70 234.4 0.1 9.2e-70 234.0 0.1 1.1 1 0 0 1 1 1 1 Mob1/phocein family SUKH-4 PF14435.6 KOG98797.1 - 0.19 11.8 0.1 23 5.0 0.1 2.2 2 0 0 2 2 2 0 SUKH-4 immunity protein PH PF00169.29 KOG98798.1 - 4.6e-11 43.1 0.2 1.1e-10 41.9 0.2 1.7 1 0 0 1 1 1 1 PH domain RTT107_BRCT_5 PF16770.5 KOG98798.1 - 0.039 13.8 0.0 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain LCIB_C_CA PF18599.1 KOG98798.1 - 1.2 8.3 4.1 0.65 9.3 0.3 2.4 2 1 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases SHQ1 PF04925.15 KOG98799.1 - 1.5e-68 229.8 1.0 2.2e-68 229.3 1.0 1.2 1 0 0 1 1 1 1 SHQ1 protein Diphthamide_syn PF01866.17 KOG98800.1 - 2.8e-113 378.4 0.0 3.9e-113 377.9 0.0 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein DPM2 PF07297.12 KOG98801.1 - 5.5e-09 36.2 1.6 6.9e-09 35.9 1.6 1.1 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) RhodobacterPufX PF11511.8 KOG98801.1 - 3 7.5 4.5 3.9 7.1 0.0 2.1 2 0 0 2 2 2 0 Intrinsic membrane protein PufX Glyco_hydro_15 PF00723.21 KOG98803.1 - 7.3e-53 179.9 0.0 1e-52 179.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Complex1_LYR_2 PF13233.6 KOG98804.1 - 3.6e-15 56.5 1.6 9.2e-15 55.2 1.6 1.8 1 1 0 1 1 1 1 Complex1_LYR-like CLTH PF10607.9 KOG98805.1 - 6.8e-34 116.9 2.8 6.8e-34 116.9 2.8 2.8 3 0 0 3 3 3 1 CTLH/CRA C-terminal to LisH motif domain Zn-C2H2_12 PF18112.1 KOG98805.1 - 0.0028 18.1 1.0 0.01 16.3 1.0 2.1 1 0 0 1 1 1 1 Autophagy receptor zinc finger-C2H2 domain U-box PF04564.15 KOG98805.1 - 0.0073 16.5 0.2 0.055 13.7 0.0 2.6 2 0 0 2 2 2 1 U-box domain Rad50_zn_hook PF04423.14 KOG98805.1 - 0.039 13.8 0.4 1.2 9.0 0.1 3.4 3 0 0 3 3 3 0 Rad50 zinc hook motif DUF2431 PF10354.9 KOG98806.1 - 9.7e-50 169.1 0.4 9.7e-50 169.1 0.4 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF2431) Pkinase PF00069.25 KOG98807.1 - 1.4e-38 132.7 0.0 2.8e-38 131.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98807.1 - 8.1e-30 104.0 0.0 1.3e-29 103.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG98807.1 - 0.0066 15.8 0.0 0.02 14.2 0.0 1.7 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 KOG98807.1 - 0.22 11.4 0.0 2.2 8.1 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Iso_dh PF00180.20 KOG98808.1 - 1.4e-113 379.6 0.1 1.6e-113 379.4 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Thi4 PF01946.17 KOG98808.1 - 0.1 11.8 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Thi4 family MRP-S25 PF13741.6 KOG98809.1 - 5.1e-93 310.9 2.1 6e-93 310.6 2.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 KOG98809.1 - 1e-06 29.0 3.0 0.0011 19.2 2.9 2.9 1 1 0 1 1 1 1 Mitochondrial ribosomal protein S23 ALMT PF11744.8 KOG98810.1 - 0.45 9.3 4.8 0.85 8.4 4.8 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter Menin PF05053.13 KOG98810.1 - 2.7 6.2 8.0 5.4 5.2 8.0 1.5 1 0 0 1 1 1 0 Menin UTP25 PF06862.12 KOG98811.1 - 2.5e-204 679.4 13.2 3.3e-204 679.0 13.2 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 KOG98811.1 - 0.00036 20.3 1.6 0.32 10.7 0.1 2.6 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG98811.1 - 0.0042 17.4 0.1 0.12 12.7 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ICE2 PF08426.10 KOG98812.1 - 3.2e-163 543.6 21.9 3.7e-163 543.4 21.9 1.0 1 0 0 1 1 1 1 ICE2 DUF4668 PF15701.5 KOG98813.1 - 7.7e-43 146.1 1.8 9.1e-43 145.9 1.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4668) Aa_trans PF01490.18 KOG98814.1 - 8.3e-139 462.8 18.2 9.5e-139 462.6 18.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Aim19 PF10315.9 KOG98815.1 - 5.2e-38 129.9 2.4 6.6e-38 129.5 2.4 1.1 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 Glyco_transf_15 PF01793.16 KOG98816.1 - 7.7e-86 288.3 19.2 4.6e-57 193.7 7.8 2.1 1 1 0 2 2 2 2 Glycolipid 2-alpha-mannosyltransferase Sds3 PF08598.11 KOG98817.1 - 7.3e-77 258.2 9.9 8.6e-77 258.0 9.9 1.0 1 0 0 1 1 1 1 Sds3-like Tim44 PF04280.15 KOG98817.1 - 0.004 17.2 0.1 0.0085 16.2 0.1 1.5 1 0 0 1 1 1 1 Tim44-like domain zf-CCHC PF00098.23 KOG98818.1 - 2.4e-09 36.8 45.3 0.00015 21.7 2.7 5.0 5 1 0 5 5 5 3 Zinc knuckle zf-CCHC_2 PF13696.6 KOG98818.1 - 0.008 16.0 42.7 0.023 14.5 1.8 5.3 5 0 0 5 5 5 4 Zinc knuckle zf-CCHC_4 PF14392.6 KOG98818.1 - 0.085 12.6 32.3 0.12 12.1 1.5 5.2 4 1 1 5 5 5 0 Zinc knuckle tRNA-synt_2b PF00587.25 KOG98819.1 - 2.8e-37 128.4 0.0 5.3e-37 127.5 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 KOG98819.1 - 2.9e-22 78.6 0.8 6.2e-22 77.6 0.8 1.6 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 KOG98819.1 - 2.8e-15 56.1 0.0 8.1e-15 54.6 0.0 1.8 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.14 KOG98819.1 - 6.6e-13 48.5 0.0 1.3e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF1689 PF07954.11 KOG98820.1 - 1.4e-57 194.3 0.8 1.7e-57 193.9 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1689) NAD_binding_10 PF13460.6 KOG98821.1 - 1.1e-46 159.1 0.0 1.2e-46 158.9 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOG98821.1 - 4.5e-11 42.8 0.0 1.2e-10 41.3 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 KOG98821.1 - 1.2e-07 31.4 0.1 2.8e-07 30.3 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOG98821.1 - 1.9e-07 30.4 0.4 2.6e-07 29.9 0.4 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 KOG98821.1 - 6.8e-06 26.5 0.1 1e-05 25.9 0.1 1.4 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 KOG98821.1 - 1.3e-05 25.3 0.1 2.6e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Ldh_1_N PF00056.23 KOG98821.1 - 0.0003 20.9 0.3 0.00042 20.4 0.3 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 KOG98821.1 - 0.11 11.5 0.2 0.18 10.9 0.2 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain GFO_IDH_MocA PF01408.22 KOG98821.1 - 0.14 13.0 0.1 0.32 11.8 0.1 1.8 1 1 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Coatomer_E PF04733.14 KOG98822.1 - 7.5e-11 42.0 12.5 1.9e-10 40.6 12.5 1.6 1 1 0 1 1 1 1 Coatomer epsilon subunit RPN2_C PF18004.1 KOG98823.1 - 9.3e-51 171.9 14.3 1.5e-50 171.2 14.3 1.4 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 KOG98823.1 - 5.4e-36 121.2 36.3 1.5e-06 28.3 0.0 10.5 11 1 1 12 12 11 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 KOG98823.1 - 2.7e-15 56.5 6.1 4.6e-14 52.6 0.2 4.3 4 1 1 5 5 5 1 HEAT repeats HEAT_EZ PF13513.6 KOG98823.1 - 1.2e-08 35.3 2.0 0.46 11.1 0.1 5.4 5 0 0 5 5 4 3 HEAT-like repeat HEAT PF02985.22 KOG98823.1 - 1e-06 28.4 5.5 0.71 10.3 0.1 4.9 5 0 0 5 5 4 3 HEAT repeat Cnd1 PF12717.7 KOG98823.1 - 0.00062 19.8 1.2 1.8 8.6 0.1 3.3 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 DUF3824 PF12868.7 KOG98823.1 - 0.044 14.4 5.6 0.11 13.2 5.6 1.6 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) RICTOR_V PF14668.6 KOG98823.1 - 0.06 13.6 0.0 0.49 10.7 0.0 2.7 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 Vac14_Fab1_bd PF12755.7 KOG98823.1 - 0.072 13.7 3.5 9.7 6.9 0.0 4.7 4 1 1 5 5 5 0 Vacuolar 14 Fab1-binding region ANAPC3 PF12895.7 KOG98823.1 - 0.075 13.3 0.1 5.7 7.2 0.1 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Ribosomal_60s PF00428.19 KOG98823.1 - 0.08 13.5 11.8 0.24 12.0 11.8 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF4775 PF16001.5 KOG98823.1 - 0.14 11.5 15.7 0.21 11.0 15.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) HEAT_PBS PF03130.16 KOG98823.1 - 0.33 11.7 4.2 41 5.3 0.1 4.6 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Striatin PF08232.12 KOG98823.1 - 0.52 10.9 10.4 0.99 10.0 10.4 1.4 1 0 0 1 1 1 0 Striatin family NARP1 PF12569.8 KOG98823.1 - 0.59 9.0 12.6 1.1 8.1 12.6 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 MRNIP PF15749.5 KOG98823.1 - 5.3 7.8 9.4 10 6.9 9.4 1.4 1 0 0 1 1 1 0 MRN-interacting protein 2-Hacid_dh_C PF02826.19 KOG98824.1 - 3.2e-53 179.7 0.0 5.1e-53 179.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOG98824.1 - 1e-39 135.2 0.1 1.4e-39 134.8 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KOG98824.1 - 4.2e-05 23.8 0.9 8.2e-05 22.8 0.2 1.9 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 KOG98824.1 - 0.0001 22.4 0.0 0.00019 21.5 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ACT PF01842.25 KOG98824.1 - 0.00037 20.2 0.0 0.0015 18.3 0.0 2.0 2 0 0 2 2 2 1 ACT domain XdhC_C PF13478.6 KOG98824.1 - 0.045 14.3 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain DUF262 PF03235.14 KOG98824.1 - 0.092 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF2703 PF10865.8 KOG98824.1 - 0.15 12.3 0.3 1 9.6 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2703) Acetyltransf_1 PF00583.25 KOG98824.1 - 0.18 12.0 0.0 0.44 10.8 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) family SPO22 PF08631.10 KOG98825.1 - 3.3e-65 220.3 6.0 3.3e-65 220.3 6.0 4.0 3 2 0 3 3 3 1 Meiosis protein SPO22/ZIP4 like HATPase_c_5 PF14501.6 KOG98825.1 - 0.012 15.5 1.0 3.7 7.5 0.1 3.3 2 0 0 2 2 2 0 GHKL domain TPR_19 PF14559.6 KOG98825.1 - 0.047 14.2 0.2 0.16 12.5 0.2 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat F_actin_bind PF08919.10 KOG98825.1 - 8.5 6.5 14.0 11 6.1 0.1 5.4 5 1 0 5 5 5 0 F-actin binding HORMA PF02301.18 KOG98826.1 - 2e-57 194.2 1.2 5.3e-57 192.8 1.2 1.8 1 0 0 1 1 1 1 HORMA domain PCI PF01399.27 KOG98827.1 - 0.008 16.7 0.3 0.027 15.0 0.3 2.1 1 1 0 1 1 1 1 PCI domain CH PF00307.31 KOG98827.1 - 0.18 12.0 3.1 0.52 10.5 0.2 2.6 2 0 0 2 2 2 0 Calponin homology (CH) domain SNAPc19 PF15497.6 KOG98827.1 - 0.76 10.3 7.0 1.4 9.5 0.3 2.8 3 0 0 3 3 3 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 MAM33 PF02330.16 KOG98828.1 - 1.4e-60 204.9 7.1 1.6e-60 204.7 7.1 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein MiaE_2 PF13794.6 KOG98828.1 - 0.066 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like Ribosomal_S24e PF01282.19 KOG98829.1 - 2.8e-35 120.1 0.1 4.5e-35 119.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e RAMPs PF03787.15 KOG98829.1 - 0.026 14.6 0.4 1.5 8.8 0.0 2.1 2 0 0 2 2 2 0 RAMP superfamily Sec6 PF06046.13 KOG98830.1 - 2.5e-183 610.6 11.2 4e-183 609.9 11.2 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec6 DUF1908 PF08926.11 KOG98830.1 - 0.075 12.1 2.2 0.065 12.3 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1908) LCCL PF03815.19 KOG98831.1 - 4.5e-09 36.3 0.1 7.8e-09 35.5 0.1 1.3 1 0 0 1 1 1 1 LCCL domain Ribonuc_red_lgC PF02867.15 KOG98832.1 - 2.6e-179 597.1 0.0 3.3e-179 596.8 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 KOG98832.1 - 1.9e-23 82.3 0.0 6.1e-23 80.6 0.0 2.0 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 KOG98832.1 - 7.2e-17 61.7 0.0 2e-16 60.4 0.0 1.8 1 0 0 1 1 1 1 ATP cone domain JUPITER PF17054.5 KOG98832.1 - 0.32 10.4 2.4 0.17 11.3 0.4 1.5 2 0 0 2 2 2 0 Microtubule-Associated protein Jupiter Fis1_TPR_C PF14853.6 KOG98833.1 - 1.3e-25 89.2 0.9 2.1e-25 88.6 0.9 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 KOG98833.1 - 3.8e-14 52.0 0.0 6e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_19 PF14559.6 KOG98833.1 - 0.06 13.9 0.0 0.096 13.2 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Ran_BP1 PF00638.18 KOG98834.1 - 6.8e-43 145.8 0.7 6.8e-43 145.8 0.7 2.2 2 0 0 2 2 2 1 RanBP1 domain Peptidase_S64 PF08192.11 KOG98834.1 - 3 6.2 15.2 3.9 5.8 15.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 P16-Arc PF04699.14 KOG98835.1 - 1.5e-44 152.1 0.0 1.7e-44 151.9 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 KOG98835.1 - 0.024 15.0 0.0 0.082 13.2 0.0 1.7 2 0 0 2 2 2 0 Dip2/Utp12 Family U1snRNP70_N PF12220.8 KOG98836.1 - 6.8e-20 71.5 2.6 6.8e-20 71.5 2.6 2.2 2 0 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 KOG98836.1 - 1.2e-15 57.1 0.1 2.5e-15 56.1 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOG98836.1 - 1.3e-05 25.2 0.1 3.1e-05 24.0 0.1 1.6 1 1 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 KOG98836.1 - 0.039 14.0 0.1 0.076 13.0 0.1 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF3906 PF13046.6 KOG98836.1 - 0.054 13.6 0.2 0.097 12.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3906) RGI1 PF10843.8 KOG98837.1 - 5.3e-35 120.8 10.4 9.9e-35 120.0 10.4 1.4 1 1 0 1 1 1 1 Respiratory growth induced protein 1 CENP-L PF13092.6 KOG98837.1 - 0.037 14.3 0.1 0.039 14.2 0.1 1.2 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 Vhr1 PF04001.13 KOG98838.1 - 2e-45 153.0 3.1 4.9e-45 151.8 3.1 1.7 1 0 0 1 1 1 1 Transcription factor Vhr1 HAD_2 PF13419.6 KOG98840.1 - 4.2e-16 59.6 0.0 5.6e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOG98840.1 - 2.2e-12 47.7 0.0 4.5e-10 40.2 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOG98840.1 - 0.0014 18.6 0.0 0.0026 17.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 KOG98840.1 - 0.0032 17.9 0.0 0.0044 17.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Ribonuc_L-PSP PF01042.21 KOG98841.1 - 8.7e-43 145.2 1.1 1e-42 145.0 1.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Cyclin PF08613.11 KOG98842.1 - 3.3e-53 180.3 0.1 6.1e-53 179.5 0.1 1.4 1 0 0 1 1 1 1 Cyclin Steroid_dh PF02544.16 KOG98843.1 - 1.3e-11 44.7 3.9 1.3e-11 44.7 3.9 1.8 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Curto_V3 PF07436.11 KOG98843.1 - 0.11 12.9 0.2 1.3 9.5 0.0 2.4 2 0 0 2 2 2 0 Curtovirus V3 protein PhoLip_ATPase_C PF16212.5 KOG98844.1 - 2.7e-50 171.5 19.3 2.7e-50 171.5 19.3 2.1 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KOG98844.1 - 2.6e-17 62.2 0.8 2.6e-17 62.2 0.8 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 KOG98844.1 - 1.2e-14 54.2 0.0 3.9e-14 52.6 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 KOG98844.1 - 4.6e-11 42.7 0.0 5.7e-10 39.2 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOG98844.1 - 6.5e-11 42.9 1.2 6.6e-06 26.6 0.8 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KOG98844.1 - 0.00023 21.0 0.0 0.0012 18.6 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2070 PF09843.9 KOG98844.1 - 3.6 5.8 11.0 9.2 4.4 11.0 1.7 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) EXS PF03124.14 KOG98845.1 - 1e-90 304.4 27.2 1.7e-90 303.7 27.2 1.4 1 0 0 1 1 1 1 EXS family SPX PF03105.19 KOG98845.1 - 7.6e-37 128.1 7.7 3.1e-23 83.3 0.0 2.8 2 1 1 3 3 3 2 SPX domain Mid2 PF04478.12 KOG98845.1 - 0.069 13.0 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Phage_Mu_Gam PF07352.12 KOG98845.1 - 0.15 11.9 1.0 0.34 10.8 1.0 1.5 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein RrnaAD PF00398.20 KOG98845.1 - 0.17 11.0 2.8 0.67 9.0 0.2 2.2 1 1 1 2 2 2 0 Ribosomal RNA adenine dimethylase WD40 PF00400.32 KOG98846.1 - 2.2e-32 110.6 29.5 1.7e-06 28.6 0.7 8.0 7 1 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 KOG98846.1 - 2.7e-14 52.8 2.1 5.2e-14 51.9 2.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOG98846.1 - 2.4e-10 40.0 1.0 6.1e-10 38.7 1.0 1.8 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 KOG98846.1 - 5.4e-10 38.6 6.5 0.19 10.4 0.0 5.7 2 2 4 6 6 6 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 KOG98846.1 - 1.5e-05 25.2 0.1 2.1 8.7 0.0 5.1 2 2 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOG98846.1 - 0.008 15.5 0.2 0.86 8.9 0.0 3.0 2 1 1 3 3 3 1 WD40-like domain CBM_21 PF03370.13 KOG98847.1 - 4.9e-31 107.2 1.0 1e-30 106.2 1.0 1.6 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 KOG98847.1 - 3.2e-08 34.0 3.9 7.9e-08 32.8 3.9 1.7 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) ArfGap PF01412.18 KOG98848.1 - 3.1e-38 130.5 0.7 3.1e-38 130.5 0.7 2.3 2 1 0 2 2 2 1 Putative GTPase activating protein for Arf CCDC84 PF14968.6 KOG98848.1 - 0.58 9.7 8.6 1.1 8.8 8.6 1.4 1 1 0 1 1 1 0 Coiled coil protein 84 IFT46_B_C PF12317.8 KOG98848.1 - 1.7 8.4 5.4 2.7 7.7 1.3 2.2 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal NAD_binding_1 PF00175.21 KOG98849.1 - 1.6e-33 115.6 0.0 2.8e-33 114.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOG98849.1 - 5.7e-32 110.0 0.0 9.1e-32 109.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 KOG98849.1 - 1.4e-07 31.8 0.0 0.0011 19.1 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain BCDHK_Adom3 PF10436.9 KOG98850.1 - 7.1e-22 78.0 0.2 1e-21 77.4 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 KOG98850.1 - 3.2e-16 59.8 0.0 5.7e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KOG98850.1 - 0.0055 16.5 0.0 0.0088 15.9 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BAR_2 PF10455.9 KOG98851.1 - 1.9e-89 299.6 10.9 1.9e-89 299.6 10.9 1.7 1 1 1 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 KOG98851.1 - 3.8e-12 46.4 6.2 3.8e-12 46.4 6.2 2.1 2 1 1 3 3 3 1 BAR domain LKAAEAR PF15478.6 KOG98851.1 - 0.01 16.1 1.3 0.01 16.1 1.3 2.3 2 1 0 2 2 2 0 Family of unknown function with LKAAEAR motif APG6_N PF17675.1 KOG98851.1 - 0.19 12.2 0.2 0.19 12.2 0.2 3.2 3 1 0 3 3 3 0 Apg6 coiled-coil region Lectin_N PF03954.14 KOG98851.1 - 1.5 8.5 5.9 1.9 8.2 0.2 3.0 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain Apq12 PF12716.7 KOG98852.1 - 7.8e-05 22.5 7.3 7.8e-05 22.5 7.3 1.9 2 0 0 2 2 2 1 Nuclear pore assembly and biogenesis Metallophos PF00149.28 KOG98853.1 - 1.7e-10 41.8 5.0 1.7e-09 38.5 5.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase GLEYA PF10528.9 KOG98853.1 - 0.015 15.7 0.4 0.099 13.1 0.1 2.3 2 0 0 2 2 2 0 GLEYA domain Acyl-CoA_ox_N PF14749.6 KOG98853.1 - 0.13 12.8 0.1 0.26 11.8 0.1 1.4 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal Not3 PF04065.15 KOG98854.1 - 8e-81 270.9 28.6 8e-81 270.9 28.6 3.0 2 1 1 3 3 3 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 KOG98854.1 - 9.6e-21 74.2 0.4 9.6e-21 74.2 0.4 3.3 3 0 0 3 3 3 1 NOT2 / NOT3 / NOT5 family EcsC PF12787.7 KOG98854.1 - 3.1 7.4 6.3 3.2 7.4 0.0 3.4 2 1 0 3 3 3 0 EcsC protein family DUF5389 PF17364.2 KOG98855.1 - 0.97 9.5 7.8 5.2 7.2 0.1 3.8 2 1 1 3 3 3 0 Family of unknown function (DUF5389) Orf78 PF06024.12 KOG98855.1 - 2.1 8.7 9.2 4.4 7.7 0.1 3.6 2 1 2 4 4 4 0 Orf78 (ac78) bZIP_1 PF00170.21 KOG98856.1 - 2.1e-15 56.5 8.7 7.2e-15 54.8 8.7 2.0 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KOG98856.1 - 1.4e-06 28.2 7.4 5.4e-06 26.4 7.4 2.0 1 0 0 1 1 1 1 Basic region leucine zipper MCR_alpha PF02249.17 KOG98856.1 - 0.094 13.2 2.6 0.26 11.7 0.4 2.4 2 0 0 2 2 2 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain bZIP_Maf PF03131.17 KOG98856.1 - 0.72 10.4 9.5 0.038 14.5 3.3 2.2 2 0 0 2 2 2 0 bZIP Maf transcription factor Pkinase PF00069.25 KOG98857.1 - 7e-58 196.1 5.7 5.2e-51 173.5 0.8 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98857.1 - 2.6e-18 66.3 1.2 8.5e-13 48.2 0.0 2.4 1 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 KOG98857.1 - 2.3e-05 24.4 0.1 5.5e-05 23.2 0.1 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOG98857.1 - 0.008 15.0 0.4 0.019 13.8 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Choline_kinase PF01633.20 KOG98857.1 - 0.014 15.0 0.6 0.04 13.5 0.1 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.14 KOG98857.1 - 0.032 13.6 0.5 0.079 12.3 0.4 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family F_actin_cap_B PF01115.17 KOG98858.1 - 7.8e-95 317.0 0.0 8.9e-95 316.8 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit cNMP_binding PF00027.29 KOG98859.1 - 1.1e-43 147.2 0.1 2.4e-21 75.6 0.0 3.0 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain RIIa PF02197.17 KOG98859.1 - 1.3e-14 53.5 3.1 3.9e-14 52.0 3.1 1.9 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Ribosomal_L27 PF01016.19 KOG98859.1 - 0.036 14.1 0.2 0.15 12.1 0.2 2.0 1 1 0 1 1 1 0 Ribosomal L27 protein ATP-synt_DE_N PF02823.16 KOG98859.1 - 0.19 11.6 0.4 16 5.5 0.0 2.3 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Cupin_2 PF07883.11 KOG98859.1 - 0.2 11.4 0.3 26 4.6 0.0 2.3 2 0 0 2 2 2 0 Cupin domain Peptidase_C48 PF02902.19 KOG98860.1 - 3.5e-45 154.5 9.0 3.5e-45 154.5 9.0 2.5 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain RINGv PF12906.7 KOG98861.1 - 6.5e-16 58.2 4.9 1.2e-15 57.3 4.9 1.5 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 KOG98861.1 - 0.15 12.4 5.7 0.48 10.8 5.9 1.8 1 1 0 1 1 1 0 Ring finger domain DUF2062 PF09835.9 KOG98862.1 - 1.6 8.5 9.4 0.051 13.4 2.2 2.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2062) MMgT PF10270.9 KOG98863.1 - 8.2e-26 90.3 0.7 2.7e-25 88.6 0.7 1.7 1 1 0 1 1 1 1 Membrane magnesium transporter STAG PF08514.11 KOG98864.1 - 1.5e-24 86.1 1.5 1.5e-24 86.1 1.5 3.0 2 0 0 2 2 2 1 STAG domain TryThrA_C PF12319.8 KOG98864.1 - 0.045 13.2 0.3 29 4.1 0.0 4.0 4 0 0 4 4 4 0 Tryptophan-Threonine-rich plasmodium antigen C terminal EBV-NA3 PF05009.12 KOG98864.1 - 7 6.1 10.1 0.38 10.3 0.1 2.6 2 0 0 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) AMPK1_CBM PF16561.5 KOG98865.1 - 2.9e-07 30.6 1.3 6.7e-07 29.4 1.3 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase Zip PF02535.22 KOG98866.1 - 3.4e-56 190.9 27.4 1.7e-43 149.2 10.5 2.3 2 1 1 3 3 3 2 ZIP Zinc transporter Tim44 PF04280.15 KOG98867.1 - 1e-38 132.7 0.3 2.2e-38 131.6 0.1 1.7 2 0 0 2 2 2 1 Tim44-like domain RNA_pol_A_bac PF01000.26 KOG98868.1 - 5.4e-32 110.5 0.3 1.3e-31 109.2 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 KOG98868.1 - 8.4e-18 63.6 0.0 1.1e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain His_biosynth PF00977.21 KOG98869.1 - 3.1e-28 98.8 0.0 3.8e-28 98.5 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein DUF4602 PF15375.6 KOG98870.1 - 0.013 15.8 4.3 0.013 15.8 4.3 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4602) DUF4746 PF15928.5 KOG98870.1 - 0.017 14.5 1.8 0.017 14.5 1.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4746) Ribosomal_L2_C PF03947.18 KOG98871.1 - 1.5e-44 151.3 3.3 2.4e-44 150.6 3.3 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 KOG98871.1 - 1.4e-13 50.6 0.2 3.5e-13 49.3 0.2 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain HEAT PF02985.22 KOG98872.1 - 0.0042 17.2 0.4 11 6.6 0.1 4.7 4 0 0 4 4 4 1 HEAT repeat GCIP PF13324.6 KOG98872.1 - 0.036 13.7 2.1 7.9 6.0 0.0 2.5 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting CENP-B_dimeris PF09026.10 KOG98872.1 - 0.14 12.6 7.3 0.37 11.2 7.3 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 KOG98872.1 - 4.5 6.5 8.1 7.4 5.8 8.1 1.2 1 0 0 1 1 1 0 NOA36 protein BAG PF02179.16 KOG98873.1 - 1.8e-15 57.1 2.1 3e-15 56.4 2.1 1.4 1 0 0 1 1 1 1 BAG domain Wound_ind PF08186.11 KOG98873.1 - 0.068 13.6 1.8 0.068 13.6 1.8 1.8 2 0 0 2 2 2 0 Wound-inducible basic protein family Ost5 PF05251.12 KOG98873.1 - 0.088 13.1 0.5 0.17 12.1 0.5 1.5 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit 5 DUF2615 PF11027.8 KOG98873.1 - 0.19 11.8 0.0 0.33 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) Asp PF00026.23 KOG98874.1 - 5.7e-86 288.8 3.0 5.7e-86 288.8 3.0 1.9 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOG98874.1 - 1.6e-12 48.0 0.1 1.6e-12 48.0 0.1 2.4 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal ABC2_membrane PF01061.24 KOG98875.1 - 3.2e-66 222.8 61.9 1.2e-33 116.4 31.5 2.9 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 KOG98875.1 - 1e-27 97.3 0.0 1.3e-15 58.1 0.1 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 KOG98875.1 - 6.9e-25 86.8 18.0 2.2e-23 81.9 0.3 3.5 3 0 0 3 3 2 2 CDR ABC transporter AAA_21 PF13304.6 KOG98875.1 - 0.0001 22.2 2.3 0.029 14.2 0.2 2.6 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KOG98875.1 - 0.00017 21.6 0.2 0.00032 20.6 0.2 1.4 1 0 0 1 1 1 1 RsgA GTPase ABC2_membrane_3 PF12698.7 KOG98875.1 - 0.00039 19.6 58.1 0.0014 17.8 13.2 3.8 3 1 1 4 4 4 2 ABC-2 family transporter protein SMC_N PF02463.19 KOG98875.1 - 0.0019 17.7 0.0 0.079 12.4 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOG98875.1 - 0.0065 17.0 0.0 0.014 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOG98875.1 - 0.015 15.8 0.0 0.041 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOG98875.1 - 0.018 15.4 0.1 0.037 14.4 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 KOG98875.1 - 0.022 15.0 0.0 0.055 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOG98875.1 - 0.07 12.9 0.5 0.22 11.3 0.5 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRP1_TIP1 PF00660.17 KOG98876.1 - 2.6e-35 120.4 1.0 5.4e-35 119.4 1.0 1.5 1 0 0 1 1 1 1 Seripauperin and TIP1 family FAM196 PF15265.6 KOG98876.1 - 0.12 11.9 17.9 0.14 11.6 17.9 1.1 1 0 0 1 1 1 0 FAM196 family Neur_chan_memb PF02932.16 KOG98876.1 - 0.28 11.2 3.9 0.38 10.8 3.9 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 KOG98876.1 - 1.5 6.8 19.5 2 6.5 19.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SOG2 PF10428.9 KOG98876.1 - 1.9 7.6 34.7 2.4 7.2 34.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Utp14 PF04615.13 KOG98876.1 - 3.8 6.0 27.0 4.8 5.6 27.0 1.0 1 0 0 1 1 1 0 Utp14 protein BUD22 PF09073.10 KOG98876.1 - 4.8 6.4 29.8 7.4 5.8 29.8 1.2 1 0 0 1 1 1 0 BUD22 AhpC-TSA PF00578.21 KOG98877.1 - 4.3e-27 94.5 0.0 6.2e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KOG98877.1 - 2.3e-19 69.6 0.0 3.1e-19 69.1 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 KOG98877.1 - 0.058 13.5 0.0 0.09 12.9 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme TPP1 PF10341.9 KOG98878.1 - 8.5e-08 32.2 0.0 1.1e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD Sugar_tr PF00083.24 KOG98879.1 - 2.6e-171 570.5 33.5 3e-171 570.3 33.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG98879.1 - 5.7e-35 120.9 33.4 3.3e-32 111.8 20.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 KOG98879.1 - 0.0086 14.5 5.6 0.047 12.1 1.8 2.2 2 0 0 2 2 2 2 Transmembrane secretion effector Urm1 PF09138.11 KOG98880.1 - 2.3e-34 117.6 0.5 2.6e-34 117.5 0.5 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 KOG98880.1 - 0.0039 17.8 0.0 0.0055 17.3 0.0 1.3 1 0 0 1 1 1 1 ThiS family Nas2_N PF18265.1 KOG98881.1 - 2.9e-22 78.4 0.2 5.1e-22 77.6 0.2 1.4 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ PF00595.24 KOG98881.1 - 1.3e-09 38.2 0.2 2.5e-09 37.3 0.2 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KOG98881.1 - 2.5e-06 27.2 0.0 5.3e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOG98881.1 - 1.4e-05 25.3 0.0 3.5e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 KOG98881.1 - 0.0042 17.4 0.0 0.0078 16.5 0.0 1.4 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain Mito_carr PF00153.27 KOG98882.1 - 1.6e-69 229.9 1.1 2.2e-24 85.2 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Thioredoxin PF00085.20 KOG98883.1 - 1.6e-27 95.5 1.6 5.4e-22 77.7 0.0 3.7 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.6 KOG98883.1 - 5e-06 26.5 10.8 6.6e-06 26.2 1.1 3.4 3 0 0 3 3 3 1 Thioredoxin-like domain OST3_OST6 PF04756.13 KOG98883.1 - 1.9e-05 24.2 6.1 0.14 11.5 0.1 4.4 3 1 0 4 4 4 3 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 KOG98883.1 - 0.0016 18.8 5.6 0.71 10.3 0.0 3.8 4 1 0 4 4 4 2 Thioredoxin-like domain DUF1907 PF08925.11 KOG98883.1 - 0.036 13.5 0.0 0.07 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1907) Use1 PF09753.9 KOG98884.1 - 0.00059 19.6 0.0 0.00068 19.4 0.0 1.0 1 0 0 1 1 1 1 Membrane fusion protein Use1 Golgin_A5 PF09787.9 KOG98884.1 - 0.22 11.0 4.1 1.4 8.3 4.0 1.8 1 1 1 2 2 2 0 Golgin subfamily A member 5 Sec20 PF03908.13 KOG98884.1 - 0.25 11.3 1.3 1.1 9.2 0.7 2.0 1 1 1 2 2 2 0 Sec20 ParA PF10609.9 KOG98885.1 - 1.1e-95 319.8 0.0 1.3e-95 319.6 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 KOG98885.1 - 8.6e-10 38.8 0.0 6.9e-09 35.8 0.0 2.2 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 KOG98885.1 - 5.3e-07 29.7 0.1 2.8e-06 27.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 KOG98885.1 - 8e-07 28.6 0.0 3.2e-06 26.6 0.0 1.8 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 KOG98885.1 - 2.6e-05 23.6 0.4 7.3e-05 22.1 0.2 1.8 2 0 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 KOG98885.1 - 0.0012 18.3 0.2 0.13 11.7 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MeaB PF03308.16 KOG98885.1 - 0.0067 15.4 0.2 0.011 14.8 0.2 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 KOG98885.1 - 0.055 13.1 0.1 0.089 12.4 0.1 1.3 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 KOG98885.1 - 0.087 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase CBP_BcsQ PF06564.12 KOG98885.1 - 0.26 10.7 0.0 0.9 9.0 0.0 1.8 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ FlaC_arch PF05377.11 KOG98886.1 - 0.017 15.5 0.3 0.044 14.2 0.2 1.6 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) HR1 PF02185.16 KOG98886.1 - 0.041 14.0 0.1 0.065 13.3 0.1 1.3 1 0 0 1 1 1 0 Hr1 repeat Bap31_Bap29_C PF18035.1 KOG98886.1 - 0.19 11.8 3.4 0.28 11.2 3.4 1.3 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain Syja_N PF02383.18 KOG98887.1 - 7.4e-45 153.6 1.7 1e-44 153.2 0.2 1.8 2 0 0 2 2 2 1 SacI homology domain Exo_endo_phos PF03372.23 KOG98887.1 - 7.9e-14 51.7 0.0 1.3e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BTB PF00651.31 KOG98888.1 - 2e-32 111.7 0.9 6.3e-20 71.5 0.0 2.4 2 0 0 2 2 2 2 BTB/POZ domain Ank_4 PF13637.6 KOG98888.1 - 7.2e-07 29.6 0.0 7.4e-06 26.4 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOG98888.1 - 3.4e-05 24.4 0.0 0.00013 22.5 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOG98888.1 - 0.0018 18.6 0.1 0.064 13.7 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 KOG98888.1 - 0.0093 16.3 0.0 0.029 14.7 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOG98888.1 - 0.025 15.1 0.0 0.61 10.8 0.0 3.2 2 0 0 2 2 2 0 Ankyrin repeat RRM_1 PF00076.22 KOG98889.1 - 8.2e-21 73.6 0.0 1.4e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOG98889.1 - 0.0011 18.8 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.5 KOG98889.1 - 0.09 12.9 0.0 0.51 10.5 0.0 2.3 1 1 0 1 1 1 0 RNA recognition motif ResIII PF04851.15 KOG98890.1 - 6.6e-22 78.3 0.9 3.2e-20 72.8 0.0 3.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOG98890.1 - 1.1e-19 70.7 0.7 3.8e-18 65.9 0.1 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOG98890.1 - 1.4e-16 60.7 0.1 1.5e-15 57.4 0.0 2.8 4 0 0 4 4 4 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOG98890.1 - 0.00067 19.9 0.0 0.58 10.4 0.0 2.9 2 1 0 2 2 2 2 AAA domain Latarcin PF10279.9 KOG98890.1 - 0.0024 18.2 0.0 0.098 13.1 0.0 3.6 4 2 0 4 4 4 1 Latarcin precursor PhoH PF02562.16 KOG98890.1 - 0.03 13.8 0.0 0.084 12.3 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein Thioredox_DsbH PF03190.15 KOG98890.1 - 0.041 13.8 0.0 0.087 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Aim21 PF11489.8 KOG98891.1 - 6.1e-17 61.8 55.8 6.1e-17 61.8 55.8 2.7 2 1 1 3 3 3 1 Altered inheritance of mitochondria protein 21 DnaJ-X PF14308.6 KOG98892.1 - 9.8e-79 263.7 6.6 9.8e-79 263.7 6.6 2.8 2 1 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 KOG98892.1 - 4.7e-24 84.3 0.9 1.3e-23 82.9 0.9 1.8 1 0 0 1 1 1 1 DnaJ domain Condensin2nSMC PF12422.8 KOG98892.1 - 0.16 12.2 0.5 0.6 10.3 0.1 2.1 2 1 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit Apt1 PF10351.9 KOG98892.1 - 0.65 8.8 12.1 1.4 7.6 0.1 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain CDC45 PF02724.14 KOG98892.1 - 2.3 6.4 12.9 0.87 7.8 9.9 1.7 2 0 0 2 2 2 0 CDC45-like protein RRM_1 PF00076.22 KOG98893.1 - 1.6e-19 69.5 0.0 2.5e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOG98893.1 - 0.075 13.2 0.0 0.16 12.1 0.0 1.6 1 1 0 1 1 1 0 RNA recognition motif EF-hand_4 PF12763.7 KOG98894.1 - 8.9e-27 93.1 0.0 3.5e-13 49.4 0.0 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF1720 PF08226.11 KOG98894.1 - 3.2e-08 33.9 56.8 5.9e-07 29.8 25.0 12.5 6 3 4 11 11 11 5 Domain of unknown function (DUF1720) EF-hand_7 PF13499.6 KOG98894.1 - 1.1e-05 25.8 0.0 0.031 14.7 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KOG98894.1 - 3.1e-05 23.2 0.0 0.02 14.4 0.0 3.6 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 KOG98894.1 - 0.00055 19.7 0.3 7 6.9 0.0 4.3 5 0 0 5 5 5 1 EF-hand domain E3_binding PF02817.17 KOG98894.1 - 0.052 13.9 0.1 0.2 12.0 0.0 2.0 2 0 0 2 2 2 0 e3 binding domain Cellulase PF00150.18 KOG98895.1 - 2.1e-15 56.9 0.1 1.8e-09 37.5 0.0 2.6 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 KOG98895.1 - 3.6e-12 46.6 0.1 7.8e-12 45.6 0.1 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Glyco_hydro_35 PF01301.19 KOG98895.1 - 0.0047 16.6 0.0 0.0096 15.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 SIR2_2 PF13289.6 KOG98895.1 - 0.014 15.5 0.0 0.13 12.4 0.0 2.3 2 0 0 2 2 2 0 SIR2-like domain Glyco_hydro_14 PF01373.17 KOG98895.1 - 0.039 12.9 0.0 0.063 12.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 14 DNA_primase_S PF01896.19 KOG98896.1 - 5.5e-65 218.7 0.5 7.6e-65 218.3 0.5 1.2 1 0 0 1 1 1 1 DNA primase small subunit RRM_5 PF13893.6 KOG98897.1 - 1.7e-08 34.1 0.0 1.9e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 KOG98897.1 - 1.4e-07 31.2 0.2 2.6e-07 30.3 0.2 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIS13 PF08202.11 KOG98898.1 - 5.1e-95 318.2 15.9 5.1e-95 318.2 15.9 1.4 2 0 0 2 2 2 1 Mis12-Mtw1 protein family Cut8 PF08559.10 KOG98899.1 - 2.2e-75 253.4 5.1 3.3e-75 252.8 5.1 1.1 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein ANAPC4_WD40 PF12894.7 KOG98900.1 - 1e-06 29.0 0.2 0.00098 19.4 0.0 3.5 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 KOG98900.1 - 0.00077 19.1 0.0 2.4 7.7 0.0 3.1 1 1 1 3 3 3 2 PQQ-like domain PQQ PF01011.21 KOG98900.1 - 0.13 12.2 0.2 1.7 8.7 0.0 2.8 3 0 0 3 3 3 0 PQQ enzyme repeat GATA PF00320.27 KOG98901.1 - 3.3e-14 52.2 4.3 5.1e-14 51.6 4.3 1.3 1 0 0 1 1 1 1 GATA zinc finger Rpr2 PF04032.16 KOG98903.1 - 4.3e-12 46.2 0.1 7.2e-12 45.4 0.1 1.4 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF1844 PF08899.11 KOG98903.1 - 0.099 12.9 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1844) Rrp44_CSD1 PF17216.3 KOG98904.1 - 0.1 12.3 2.3 0.16 11.7 2.3 1.3 1 0 0 1 1 1 0 Rrp44-like cold shock domain bZIP_2 PF07716.15 KOG98905.1 - 6.9e-10 38.9 12.8 6.9e-10 38.9 12.8 2.0 2 0 0 2 2 2 1 Basic region leucine zipper LidA_Long_CC PF18641.1 KOG98905.1 - 0.003 17.6 7.2 0.0034 17.5 5.3 1.9 1 1 1 2 2 2 1 LidA long coiled-coil domain bZIP_Maf PF03131.17 KOG98905.1 - 0.0084 16.6 9.6 0.0084 16.6 9.6 2.6 2 1 1 3 3 3 1 bZIP Maf transcription factor TSC22 PF01166.18 KOG98905.1 - 0.094 13.0 2.5 0.26 11.6 1.3 2.3 2 0 0 2 2 2 0 TSC-22/dip/bun family bZIP_1 PF00170.21 KOG98905.1 - 0.31 11.2 19.7 0.21 11.7 16.1 2.5 2 1 0 2 2 2 0 bZIP transcription factor LPP PF04728.13 KOG98905.1 - 0.93 9.9 0.1 0.93 9.9 0.1 3.2 4 0 0 4 4 4 0 Lipoprotein leucine-zipper DivIC PF04977.15 KOG98905.1 - 1 9.2 8.3 0.19 11.5 0.8 2.5 2 0 0 2 2 2 0 Septum formation initiator SOGA PF11365.8 KOG98905.1 - 1.4 10.1 11.6 0.43 11.8 7.6 2.0 2 1 1 3 3 3 0 Protein SOGA BBS1 PF14779.6 KOG98905.1 - 4.2 6.7 5.4 4.6 6.6 0.1 2.2 1 1 0 2 2 2 0 Ciliary BBSome complex subunit 1 bZIP_1 PF00170.21 KOG98906.1 - 3.8e-06 26.9 14.1 2.1e-05 24.5 12.3 2.5 1 1 1 2 2 2 1 bZIP transcription factor MAD PF05557.13 KOG98906.1 - 5.3e-05 21.8 7.5 7.1e-05 21.4 7.5 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein SlyX PF04102.12 KOG98906.1 - 0.0014 19.2 2.3 0.0014 19.2 2.3 3.4 3 1 0 3 3 2 1 SlyX ERM PF00769.19 KOG98906.1 - 0.0026 17.6 5.3 0.0035 17.2 5.3 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family APG6_N PF17675.1 KOG98906.1 - 0.0044 17.5 7.5 0.0092 16.5 7.5 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region Prefoldin_2 PF01920.20 KOG98906.1 - 0.0062 16.5 2.6 0.0062 16.5 2.6 1.8 1 1 0 1 1 1 1 Prefoldin subunit Cep57_CLD PF14073.6 KOG98906.1 - 0.0064 16.5 8.4 0.011 15.8 8.4 1.3 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 DUF4515 PF14988.6 KOG98906.1 - 0.0065 16.3 11.1 0.0095 15.8 11.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4515) GIT_CC PF16559.5 KOG98906.1 - 0.011 15.5 4.0 0.021 14.7 3.6 1.6 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Sec34 PF04136.15 KOG98906.1 - 0.015 15.2 2.3 0.022 14.6 2.3 1.3 1 0 0 1 1 1 0 Sec34-like family ADIP PF11559.8 KOG98906.1 - 0.015 15.4 9.4 0.025 14.7 9.4 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF641 PF04859.12 KOG98906.1 - 0.021 15.2 7.1 0.038 14.3 7.1 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Glutaredoxin2_C PF04399.13 KOG98906.1 - 0.021 14.7 2.1 0.033 14.0 2.1 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain HIP1_clath_bdg PF16515.5 KOG98906.1 - 0.023 15.3 10.6 0.034 14.7 10.6 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Gp58 PF07902.11 KOG98906.1 - 0.025 12.9 1.0 0.03 12.6 1.0 1.1 1 0 0 1 1 1 0 gp58-like protein Ribosomal_L20 PF00453.18 KOG98906.1 - 0.028 14.5 1.4 0.028 14.5 1.4 1.7 2 0 0 2 2 2 0 Ribosomal protein L20 ABC_tran_CTD PF16326.5 KOG98906.1 - 0.035 14.4 3.2 0.067 13.5 3.2 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain Exonuc_VII_L PF02601.15 KOG98906.1 - 0.049 13.2 4.8 0.059 12.9 4.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Jnk-SapK_ap_N PF09744.9 KOG98906.1 - 0.059 13.6 6.1 0.095 12.9 6.1 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 KOG98906.1 - 0.12 11.7 4.3 0.16 11.3 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 KOG98906.1 - 0.16 12.1 5.1 0.22 11.6 5.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 KOG98906.1 - 0.24 10.3 9.1 0.35 9.7 9.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein V_ATPase_I PF01496.19 KOG98906.1 - 0.27 9.1 3.3 0.33 8.8 3.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Syntaxin-6_N PF09177.11 KOG98906.1 - 0.81 10.3 5.0 1.6 9.3 5.0 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal YabA PF06156.13 KOG98906.1 - 1.8 9.2 7.6 0.73 10.5 4.5 2.0 1 1 1 2 2 2 0 Initiation control protein YabA CENP-H PF05837.12 KOG98906.1 - 2.3 8.6 8.7 0.57 10.6 4.5 2.0 1 1 1 2 2 2 0 Centromere protein H (CENP-H) TMPIT PF07851.13 KOG98906.1 - 2.6 7.2 3.7 3.5 6.8 3.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF724 PF05266.14 KOG98906.1 - 3.4 7.4 7.8 5.6 6.7 7.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DivIC PF04977.15 KOG98906.1 - 5.5 6.8 11.1 8.5 6.2 1.3 2.4 1 1 1 2 2 2 0 Septum formation initiator Atg14 PF10186.9 KOG98906.1 - 8.3 5.4 19.6 0.012 14.7 8.8 1.7 2 0 0 2 2 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Flo11 PF10182.9 KOG98907.1 - 8.1e-71 237.0 8.1 1.4e-70 236.2 8.1 1.4 1 0 0 1 1 1 1 Flo11 domain Ydc2-catalyt PF09159.10 KOG98908.1 - 6.9e-24 85.0 0.0 9e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Peptidase_S24 PF00717.23 KOG98909.1 - 4.2e-09 36.2 0.0 7.4e-09 35.5 0.0 1.5 1 1 0 1 1 1 1 Peptidase S24-like Gar1 PF04410.14 KOG98909.1 - 0.055 13.2 0.0 8.8 6.1 0.0 2.1 2 0 0 2 2 2 0 Gar1/Naf1 RNA binding region Fungal_trans PF04082.18 KOG98910.1 - 1.1e-30 106.5 3.1 1.1e-30 106.5 3.1 2.9 2 1 1 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG98910.1 - 3.3e-07 30.3 8.1 6.9e-07 29.3 8.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 KOG98910.1 - 0.0032 17.5 14.1 0.23 11.5 0.6 3.3 3 0 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 DUF3038 PF11237.8 KOG98910.1 - 9.6 6.2 9.2 0.3 11.1 2.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3038) DUF5321 PF17254.2 KOG98911.1 - 0.0013 18.2 2.1 0.0014 18.1 0.2 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5321) Apc15p PF05841.11 KOG98912.1 - 1.4e-34 119.6 1.4 1.4e-34 119.6 1.4 2.3 2 0 0 2 2 2 1 Apc15p protein DSPc PF00782.20 KOG98913.1 - 3.7e-25 88.3 0.1 1.2e-23 83.4 0.1 2.3 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOG98913.1 - 0.0078 15.8 0.1 0.022 14.3 0.0 1.7 1 1 0 2 2 2 1 Protein-tyrosine phosphatase Sgf11 PF08209.11 KOG98913.1 - 0.028 14.0 0.7 1.3 8.7 0.0 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Yippee-Mis18 PF03226.14 KOG98913.1 - 0.035 14.3 2.1 0.22 11.7 2.1 2.2 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Elf1 PF05129.13 KOG98913.1 - 0.036 14.1 0.4 13 5.9 0.0 2.7 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like c-SKI_SMAD_bind PF08782.10 KOG98913.1 - 0.048 13.9 0.3 0.1 12.9 0.3 1.5 1 0 0 1 1 1 0 c-SKI Smad4 binding domain Eapp_C PF10238.9 KOG98913.1 - 0.093 12.8 0.3 0.73 9.9 0.1 2.0 2 0 0 2 2 2 0 E2F-associated phosphoprotein PTPlike_phytase PF14566.6 KOG98913.1 - 0.14 12.2 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate UPF0547 PF10571.9 KOG98913.1 - 1.8 8.7 7.3 7.3 6.8 0.2 2.9 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 Amidohydro_1 PF01979.20 KOG98914.1 - 1.7e-52 178.9 0.0 2.3e-52 178.5 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KOG98914.1 - 3.7e-10 39.9 0.0 2.3e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Transp_cyt_pur PF02133.15 KOG98915.1 - 3.4e-178 593.0 35.9 3.9e-178 592.7 35.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Allantoicase PF03561.15 KOG98916.1 - 2.1e-94 313.1 0.2 4.5e-47 159.7 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat DUF512 PF04459.12 KOG98916.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF512) Asp_Glu_race PF01177.22 KOG98917.1 - 6.6e-06 26.1 0.0 4.9e-05 23.3 0.0 1.9 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase Malate_synthase PF01274.22 KOG98918.1 - 1.3e-224 746.4 0.0 1.6e-224 746.1 0.0 1.0 1 0 0 1 1 1 1 Malate synthase Ureidogly_lyase PF04115.12 KOG98919.1 - 2.3e-50 171.0 0.0 2.6e-50 170.8 0.0 1.0 1 0 0 1 1 1 1 Ureidoglycolate lyase Ank_4 PF13637.6 KOG98920.1 - 3.1e-11 43.6 0.3 9.3e-10 38.9 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOG98920.1 - 3.3e-11 43.6 0.1 1.1e-10 41.9 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOG98920.1 - 5e-11 41.8 0.2 5.5e-05 23.3 0.1 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 KOG98920.1 - 1.4e-08 34.8 0.7 0.0016 18.8 0.1 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 KOG98920.1 - 3.8e-08 33.4 0.1 4.4e-05 23.7 0.0 3.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) TIG PF01833.24 KOG98920.1 - 1.6e-07 31.3 0.4 4.9e-07 29.7 0.4 1.9 1 0 0 1 1 1 1 IPT/TIG domain AlaDh_PNT_N PF05222.15 KOG98921.1 - 1e-29 103.6 0.0 1.5e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 KOG98921.1 - 0.12 11.7 0.0 0.68 9.2 0.0 2.1 1 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 KOG98922.1 - 3.3e-49 167.0 0.4 4e-49 166.7 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOG98922.1 - 3.7e-30 105.2 0.1 4.6e-30 104.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOG98922.1 - 3.8e-07 30.2 0.0 5.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOG98922.1 - 0.0098 15.4 0.1 0.052 13.0 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 KOG98922.1 - 0.016 15.4 0.2 0.036 14.3 0.1 1.7 2 0 0 2 2 2 0 TrkA-N domain tRNA_m1G_MT PF01746.21 KOG98922.1 - 0.042 13.5 0.2 0.076 12.7 0.2 1.4 1 0 0 1 1 1 0 tRNA (Guanine-1)-methyltransferase RBDV_coat PF06593.11 KOG98922.1 - 0.048 13.1 0.6 0.07 12.6 0.6 1.3 1 0 0 1 1 1 0 Raspberry bushy dwarf virus coat protein GDP_Man_Dehyd PF16363.5 KOG98922.1 - 0.12 11.7 0.6 0.2 11.0 0.1 1.5 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 KOG98923.1 - 6.8e-52 175.8 0.0 7.9e-52 175.6 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOG98923.1 - 1.6e-34 119.5 0.0 2e-34 119.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOG98923.1 - 3e-11 43.6 0.0 4.2e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 KOG98923.1 - 0.00028 20.4 0.1 0.06 12.7 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOG98923.1 - 0.0008 18.9 0.1 0.011 15.2 0.1 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KOG98923.1 - 0.003 16.7 0.0 0.0089 15.2 0.0 1.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein GSHPx PF00255.19 KOG98924.1 - 1.2e-49 166.4 0.3 1.5e-49 166.1 0.3 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 KOG98924.1 - 1.9e-05 24.5 0.1 0.00013 21.9 0.1 2.0 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KOG98924.1 - 0.00019 21.2 0.0 0.00057 19.6 0.0 1.8 1 1 0 1 1 1 1 Redoxin GST_N PF02798.20 KOG98925.1 - 3.3e-21 75.4 0.0 5.2e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KOG98925.1 - 1.9e-15 56.8 0.0 5.8e-15 55.3 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOG98925.1 - 5.8e-08 33.0 0.0 1.3e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOG98925.1 - 7.2e-07 29.4 0.0 1.6e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KOG98925.1 - 0.00033 20.8 0.0 0.00059 20.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOG98925.1 - 0.097 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Fungal_trans PF04082.18 KOG98926.1 - 2e-18 66.4 2.2 4.7e-18 65.2 2.2 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG98926.1 - 1.7e-05 24.8 13.6 3.6e-05 23.8 13.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 KOG98927.1 - 3.4e-20 72.3 48.2 4.7e-20 71.8 47.9 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Peptidase_M20 PF01546.28 KOG98928.1 - 4.9e-35 121.1 0.0 7.9e-35 120.4 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KOG98928.1 - 2.3e-13 50.0 0.0 4.7e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain NAD_binding_6 PF08030.12 KOG98929.1 - 5e-19 69.0 0.1 7.3e-19 68.4 0.1 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 KOG98929.1 - 5e-19 68.6 9.1 5e-19 68.6 9.1 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 KOG98929.1 - 2.7e-11 43.5 0.0 7.7e-11 42.0 0.0 1.8 1 1 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.24 KOG98929.1 - 0.0074 16.6 0.0 0.022 15.1 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain DUF4405 PF14358.6 KOG98929.1 - 1.5 9.4 11.0 3.6 8.2 2.8 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) 3Beta_HSD PF01073.19 KOG98930.1 - 2.1e-13 49.9 0.0 2.7e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KOG98930.1 - 6.7e-12 45.4 0.0 1.3e-11 44.4 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KOG98930.1 - 1.4e-05 25.1 0.0 3e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 KOG98930.1 - 0.00029 20.3 0.0 0.00085 18.8 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 KOG98930.1 - 0.00062 19.3 0.1 0.0016 17.9 0.0 1.7 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 KOG98930.1 - 0.001 18.3 0.0 0.023 13.8 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 KOG98930.1 - 0.0053 15.9 0.0 0.011 14.8 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 KOG98930.1 - 0.01 15.8 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.17 KOG98930.1 - 0.016 15.8 0.0 0.45 11.1 0.0 2.7 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.13 KOG98930.1 - 0.033 13.8 0.0 0.7 9.4 0.0 2.2 2 0 0 2 2 2 0 NmrA-like family DCP1 PF06058.13 KOG98931.1 - 1.4e-25 89.5 0.4 6.5e-13 48.6 0.0 2.4 2 1 0 2 2 2 2 Dcp1-like decapping family Spt20 PF12090.8 KOG98932.1 - 9.6e-73 244.6 11.0 9.6e-73 244.6 11.0 3.4 3 0 0 3 3 3 1 Spt20 family RskA PF10099.9 KOG98932.1 - 0.086 13.1 2.9 0.13 12.6 0.3 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA PEX11 PF05648.14 KOG98933.1 - 4e-66 222.7 4.0 4.5e-66 222.5 4.0 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Sld5 PF05916.11 KOG98934.1 - 4.7e-22 78.5 0.0 5.8e-22 78.2 0.0 1.1 1 0 0 1 1 1 1 GINS complex protein TPR_2 PF07719.17 KOG98935.1 - 4.1e-29 98.3 18.1 0.018 15.1 0.0 12.1 12 0 0 12 12 11 8 Tetratricopeptide repeat TPR_1 PF00515.28 KOG98935.1 - 3.3e-20 71.0 34.9 9.3e-05 22.1 0.0 11.9 12 0 0 12 12 11 6 Tetratricopeptide repeat TPR_12 PF13424.6 KOG98935.1 - 1.1e-19 70.4 11.8 0.00055 20.2 0.0 9.9 6 3 3 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 KOG98935.1 - 2.6e-14 52.1 23.4 0.96 9.8 0.0 12.5 12 0 0 12 12 11 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOG98935.1 - 1.2e-13 50.6 1.1 0.028 15.2 0.0 10.7 9 2 3 12 12 11 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOG98935.1 - 1.6e-13 51.1 0.0 0.014 16.0 0.0 6.8 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 KOG98935.1 - 3.1e-11 43.2 14.2 1.9 9.3 0.0 12.7 14 0 0 14 14 14 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOG98935.1 - 3.7e-11 43.4 12.3 0.0094 16.4 0.1 9.9 10 2 2 12 12 12 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOG98935.1 - 1.8e-08 33.8 10.0 0.47 10.6 0.0 9.2 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOG98935.1 - 6.5e-08 32.2 7.5 0.023 14.6 0.1 8.4 9 0 0 9 9 9 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOG98935.1 - 6.5e-08 32.7 14.4 0.0073 16.5 0.0 7.6 6 4 3 9 9 9 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 KOG98935.1 - 1.1e-05 25.0 13.6 0.89 9.3 0.0 7.0 7 1 1 8 8 8 3 TPR repeat TPR_17 PF13431.6 KOG98935.1 - 5.8e-05 23.2 8.2 31 5.2 0.0 9.8 11 0 0 11 11 10 0 Tetratricopeptide repeat RRM_1 PF00076.22 KOG98936.1 - 7.5e-05 22.5 3.3 0.00051 19.8 1.7 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MAPKK1_Int PF08923.10 KOG98936.1 - 0.041 13.7 0.0 0.3 10.9 0.0 2.1 2 0 0 2 2 2 0 Mitogen-activated protein kinase kinase 1 interacting DMRL_synthase PF00885.19 KOG98937.1 - 1.1e-50 171.1 0.1 1.3e-50 170.9 0.1 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase OprF PF05736.11 KOG98937.1 - 0.1 12.3 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 OprF membrane domain KH_6 PF15985.5 KOG98938.1 - 4.2e-14 52.6 0.0 7.1e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 KOG98938.1 - 3.5e-13 49.3 0.0 6.4e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain E1_UFD PF09358.10 KOG98938.1 - 0.035 14.8 0.0 0.062 14.0 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin fold domain LCM PF04072.14 KOG98939.1 - 2.8e-32 112.2 0.0 8.9e-32 110.5 0.0 1.8 2 0 0 2 2 2 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.6 KOG98939.1 - 1e-15 57.4 1.3 1.6e-07 31.2 0.0 4.7 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.6 KOG98939.1 - 8.9e-12 44.8 5.1 0.0041 17.3 0.0 5.6 5 1 1 6 6 6 4 Kelch motif Kelch_2 PF07646.15 KOG98939.1 - 7e-09 35.3 2.9 0.0031 17.4 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 KOG98939.1 - 1.2e-08 35.0 0.0 0.46 10.8 0.0 4.9 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KOG98939.1 - 4.3e-06 26.2 0.1 0.0019 17.8 0.0 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 KOG98939.1 - 3.9e-05 23.5 0.0 0.94 9.5 0.0 4.3 4 0 0 4 4 4 2 Kelch motif PGM1_C PF18105.1 KOG98939.1 - 0.032 13.8 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 PGM1 C-terminal domain Aminotran_3 PF00202.21 KOG98940.1 - 3.4e-135 450.8 0.1 4.1e-135 450.6 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III PucR PF07905.11 KOG98940.1 - 0.0017 18.6 0.1 2.3 8.5 0.0 3.2 3 0 0 3 3 3 2 Purine catabolism regulatory protein-like family Aminotran_5 PF00266.19 KOG98940.1 - 0.008 15.2 0.0 0.013 14.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V IF4E PF01652.18 KOG98941.1 - 8.3e-54 181.7 0.2 1e-53 181.4 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Zn_ribbon_17 PF17120.5 KOG98942.1 - 5.2e-10 38.8 1.5 1.2e-09 37.6 1.5 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 KOG98942.1 - 7.6e-09 36.1 2.2 0.0018 19.1 0.0 3.9 4 0 0 4 4 2 2 WD domain, G-beta repeat zf-RING_2 PF13639.6 KOG98942.1 - 2.3e-05 24.7 4.5 7e-05 23.1 4.5 1.9 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KOG98942.1 - 6e-05 23.2 4.8 6e-05 23.2 4.8 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 KOG98942.1 - 9.4e-05 22.2 4.3 0.00034 20.4 1.9 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOG98942.1 - 0.00017 21.4 0.9 0.00017 21.4 0.9 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KOG98942.1 - 0.057 13.5 4.7 0.15 12.1 4.7 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 KOG98942.1 - 0.25 11.1 2.0 0.62 9.9 2.0 1.7 1 0 0 1 1 1 0 RING-like zinc finger DUF3795 PF12675.7 KOG98942.1 - 1.1 9.7 5.8 3.4 8.1 5.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3795) zf-B_box PF00643.24 KOG98942.1 - 1.9 8.7 4.9 11 6.3 0.1 2.4 2 0 0 2 2 2 0 B-box zinc finger zf-RING_5 PF14634.6 KOG98942.1 - 8.4 6.4 11.2 1.3 9.0 6.4 2.2 2 1 0 2 2 2 0 zinc-RING finger domain MFS_1 PF07690.16 KOG98943.1 - 3.2e-26 92.1 57.8 2.5e-25 89.2 29.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily 6PF2K PF01591.18 KOG98944.1 - 2.2e-75 252.8 3.7 3.7e-75 252.1 3.7 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_18 PF13238.6 KOG98944.1 - 0.00035 21.1 0.0 0.0011 19.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 KOG98944.1 - 0.0008 18.9 0.0 0.0016 18.0 0.0 1.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 KOG98944.1 - 0.0015 18.7 0.0 0.0028 17.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain Ploopntkinase3 PF18751.1 KOG98944.1 - 0.018 15.0 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 Med7 PF05983.11 KOG98945.1 - 3.8e-66 222.8 3.1 4.5e-66 222.6 3.1 1.0 1 0 0 1 1 1 1 MED7 protein zf-rbx1 PF12678.7 KOG98946.1 - 2.6e-23 82.1 13.3 2.6e-23 82.1 13.3 1.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KOG98946.1 - 7.2e-17 61.2 10.1 1e-16 60.7 10.1 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 KOG98946.1 - 1.2e-05 25.5 14.1 0.00059 20.1 14.1 2.4 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOG98946.1 - 0.00029 20.6 1.7 0.00029 20.6 1.7 2.7 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOG98946.1 - 0.0022 17.8 11.9 0.023 14.5 11.9 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOG98946.1 - 0.0047 16.6 1.3 0.0047 16.6 1.3 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_4 PF15227.6 KOG98946.1 - 0.14 12.4 6.7 0.28 11.4 0.4 2.5 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 KOG98946.1 - 0.99 9.3 10.8 3 7.8 4.5 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KOG98946.1 - 1.4 8.6 14.7 64 3.3 14.7 2.4 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 KOG98946.1 - 1.7 8.9 9.9 10 6.4 10.2 2.1 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_UBOX PF13445.6 KOG98946.1 - 2.3 8.3 9.5 8 6.6 9.5 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 KOG98946.1 - 2.7 8.0 10.0 14 5.7 10.0 2.2 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING-like PF08746.11 KOG98946.1 - 4.8 7.6 11.5 43 4.5 11.5 2.3 1 1 0 1 1 1 0 RING-like domain Glyco_hydro_72 PF03198.14 KOG98947.1 - 1.5e-141 471.2 3.9 1.9e-141 470.9 3.9 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 KOG98947.1 - 5.1e-05 22.9 0.1 0.00019 20.9 0.1 1.9 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF777 PF05606.11 KOG98947.1 - 0.021 14.6 0.9 0.18 11.6 0.1 2.3 2 0 0 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF777) CorA PF01544.18 KOG98949.1 - 2.4e-38 132.1 1.5 1.8e-22 80.0 0.0 2.3 1 1 0 2 2 2 2 CorA-like Mg2+ transporter protein DUF2231 PF09990.9 KOG98949.1 - 0.11 12.9 0.4 0.24 11.9 0.4 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2231) UPF0220 PF05255.11 KOG98950.1 - 6.5e-71 237.2 1.5 7.4e-71 237.0 1.5 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Pkinase PF00069.25 KOG98951.1 - 8.5e-51 172.8 0.0 1.3e-50 172.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98951.1 - 1.7e-22 80.0 0.0 2.4e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG98951.1 - 0.0051 16.2 0.0 0.0084 15.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOG98951.1 - 0.013 14.9 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOG98951.1 - 0.036 14.0 0.0 0.079 12.9 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1679 PF07914.11 KOG98951.1 - 0.055 12.3 0.1 4.3 6.1 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1679) Ribosomal_L23 PF00276.20 KOG98952.1 - 2.7e-13 50.1 3.7 1.4e-12 47.8 3.7 1.8 1 1 0 1 1 1 1 Ribosomal protein L23 Levi_coat PF01819.17 KOG98952.1 - 0.081 12.9 0.0 0.092 12.8 0.0 1.0 1 0 0 1 1 1 0 Levivirus coat protein Ldh_1_C PF02866.18 KOG98953.1 - 3.8e-55 186.4 0.0 5.5e-55 185.8 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KOG98953.1 - 6.1e-46 156.0 0.4 9.7e-46 155.4 0.4 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain TRM13 PF05206.14 KOG98954.1 - 5.7e-78 262.0 0.7 8.8e-78 261.4 0.7 1.3 1 0 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.8 KOG98954.1 - 5.7e-13 48.4 1.9 1.2e-12 47.3 1.9 1.6 1 0 0 1 1 1 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.12 KOG98954.1 - 8.1e-11 41.6 0.3 2e-10 40.4 0.3 1.7 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger DUF685 PF05085.12 KOG98954.1 - 0.0087 15.4 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF685) Methyltransf_23 PF13489.6 KOG98954.1 - 0.044 13.6 0.0 0.073 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.18 KOG98955.1 - 4.9e-11 42.7 0.0 9.3e-10 38.5 0.0 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 KOG98955.1 - 0.039 13.6 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 DNA methylase N6_Mtase PF02384.16 KOG98955.1 - 0.047 13.0 0.0 0.13 11.5 0.0 1.7 2 0 0 2 2 2 0 N-6 DNA Methylase MethyltransfD12 PF02086.15 KOG98955.1 - 0.21 11.2 5.8 4.2 7.0 0.1 3.7 3 1 0 4 4 4 0 D12 class N6 adenine-specific DNA methyltransferase RRM_1 PF00076.22 KOG98956.1 - 7.9e-34 115.3 0.2 7.7e-17 60.9 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOG98956.1 - 5e-13 49.0 0.8 4.6e-07 29.9 0.0 3.3 3 1 0 3 3 3 2 RNA recognition motif OB_RNB PF08206.11 KOG98956.1 - 0.033 13.9 0.2 8.5 6.1 0.1 2.7 2 0 0 2 2 2 0 Ribonuclease B OB domain Glyco_H_20C_C PF18088.1 KOG98956.1 - 0.078 12.8 4.2 0.15 11.9 4.2 1.4 1 0 0 1 1 1 0 Glycoside Hydrolase 20C C-terminal domain DUF5427 PF10310.9 KOG98956.1 - 1.1 8.1 17.0 2.1 7.2 17.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF4199 PF13858.6 KOG98956.1 - 5.7 7.3 17.3 0.19 12.1 10.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) Nramp PF01566.18 KOG98957.1 - 3.3e-89 299.3 16.3 3.3e-89 299.3 16.3 2.3 2 1 0 2 2 2 1 Natural resistance-associated macrophage protein Ribosomal_S19e PF01090.19 KOG98958.1 - 2e-36 124.7 0.1 2.1e-36 124.6 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e MFS_1 PF07690.16 KOG98959.1 - 7.1e-28 97.5 37.4 7.1e-28 97.5 37.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PCI PF01399.27 KOG98960.1 - 0.12 12.9 6.9 1.2 9.7 1.3 3.0 2 0 0 2 2 2 0 PCI domain GCR1_C PF12550.8 KOG98961.1 - 3.5e-23 81.7 0.6 7.6e-23 80.6 0.6 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes DDE_Tnp_4 PF13359.6 KOG98961.1 - 0.13 11.9 0.3 1.6 8.4 0.1 2.2 2 0 0 2 2 2 0 DDE superfamily endonuclease NTP_transf_2 PF01909.23 KOG98962.1 - 1.9e-19 69.7 0.3 1.5e-18 66.9 0.0 2.5 2 0 0 2 2 2 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 KOG98962.1 - 1.4e-13 50.8 0.0 5.4e-13 48.9 0.0 2.1 1 0 0 1 1 1 1 Cid1 family poly A polymerase Polbeta PF18765.1 KOG98962.1 - 0.017 15.2 0.0 0.061 13.4 0.0 2.0 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase DNA_pol_B_palm PF14792.6 KOG98962.1 - 0.04 14.1 0.0 0.098 12.9 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase beta palm RF-1 PF00472.20 KOG98963.1 - 1e-16 60.9 0.3 1.7e-16 60.2 0.3 1.2 1 0 0 1 1 1 1 RF-1 domain MRP-S28 PF10213.9 KOG98963.1 - 0.0033 17.9 0.1 0.0045 17.4 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Pkinase PF00069.25 KOG98964.1 - 3.3e-59 200.4 0.3 3.3e-59 200.4 0.3 2.4 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98964.1 - 6.9e-50 169.7 0.1 1.1e-49 169.1 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 KOG98964.1 - 6.3e-23 80.9 0.2 1.7e-22 79.5 0.0 1.9 2 0 0 2 2 2 1 P21-Rho-binding domain PH PF00169.29 KOG98964.1 - 4.3e-12 46.5 0.3 4.3e-12 46.5 0.3 1.8 2 0 0 2 2 2 1 PH domain Pkinase_fungal PF17667.1 KOG98964.1 - 3.2e-06 26.2 0.4 6.8e-06 25.1 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KOG98964.1 - 3e-05 23.5 0.3 6.3e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 Kinase-like PH_11 PF15413.6 KOG98964.1 - 0.0001 22.7 0.1 0.0001 22.7 0.1 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain RabGAP-TBC PF00566.18 KOG98965.1 - 1.4e-43 149.1 1.0 6.5e-43 146.9 0.0 2.4 2 1 0 2 2 2 1 Rab-GTPase-TBC domain DUF3404 PF11884.8 KOG98965.1 - 0.25 10.5 1.7 1.1 8.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3404) Get5_bdg PF16843.5 KOG98966.1 - 1.4e-23 82.1 0.8 6.2e-23 80.1 0.9 1.9 2 0 0 2 2 2 1 Binding domain to Get4 on Get5, Golgi to ER traffic protein Get5_C PF18514.1 KOG98966.1 - 4e-19 68.0 2.7 9e-19 66.9 0.5 2.4 2 0 0 2 2 2 1 Get5 C-terminal domain ubiquitin PF00240.23 KOG98966.1 - 6e-12 45.1 0.6 1.4e-11 44.0 0.5 1.7 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 KOG98966.1 - 1.7e-05 24.9 0.1 3.3e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 KOG98966.1 - 0.0063 16.3 0.3 0.018 14.8 0.1 1.8 1 1 1 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Erf4 PF10256.9 KOG98967.1 - 5.2e-24 84.6 0.0 7.2e-24 84.1 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family AbiJ_NTD3 PF18860.1 KOG98967.1 - 0.038 13.5 0.0 0.09 12.3 0.0 1.6 2 0 0 2 2 2 0 AbiJ N-terminal domain 3 Apolipoprotein PF01442.18 KOG98968.1 - 0.0026 17.7 19.3 0.0039 17.1 19.3 1.3 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain YtxH PF12732.7 KOG98968.1 - 0.037 14.6 8.6 0.037 14.6 8.6 2.3 1 1 1 2 2 2 0 YtxH-like protein Baculo_PEP_C PF04513.12 KOG98968.1 - 0.3 11.1 7.1 0.11 12.6 2.7 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF148 PF02520.17 KOG98968.1 - 0.33 11.1 15.4 0.54 10.4 15.4 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF148 Exonuc_VII_L PF02601.15 KOG98968.1 - 0.34 10.4 9.0 0.4 10.2 9.0 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Lyase_8_N PF08124.11 KOG98968.1 - 0.53 9.2 6.3 0.65 8.9 6.3 1.0 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain DUF883 PF05957.13 KOG98968.1 - 0.82 10.3 12.0 6.2 7.5 12.0 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Fzo_mitofusin PF04799.13 KOG98968.1 - 1 8.9 12.0 0.91 9.1 9.6 1.8 1 1 1 2 2 2 0 fzo-like conserved region DivIVA PF05103.13 KOG98968.1 - 1.1 9.3 17.6 2.5 8.2 17.6 1.7 1 1 0 1 1 1 0 DivIVA protein ZYG-11_interact PF05884.12 KOG98968.1 - 1.6 8.1 3.0 2.1 7.7 3.0 1.3 1 1 0 1 1 1 0 Interactor of ZYG-11 ALMT PF11744.8 KOG98968.1 - 1.6 7.5 12.9 1.8 7.3 12.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter TMPIT PF07851.13 KOG98968.1 - 1.9 7.6 13.4 2.3 7.4 13.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein ApoO PF09769.9 KOG98968.1 - 3.2 7.7 6.5 26 4.8 6.5 2.1 1 1 0 1 1 1 0 Apolipoprotein O Prominin PF05478.11 KOG98968.1 - 4.2 5.2 8.5 4.2 5.2 8.5 1.1 1 0 0 1 1 1 0 Prominin DUF4407 PF14362.6 KOG98968.1 - 5.1 6.4 15.6 5.7 6.2 15.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AIF-MLS PF14962.6 KOG98968.1 - 6.8 6.6 16.5 8 6.4 16.5 1.1 1 0 0 1 1 1 0 Mitochondria Localisation Sequence Ig_Tie2_1 PF10430.9 KOG98968.1 - 6.9 7.2 8.4 2.5 8.6 1.2 2.1 1 1 1 2 2 2 0 Tie-2 Ig-like domain 1 ATP11 PF06644.11 KOG98968.1 - 7.8 6.2 16.4 12 5.6 16.4 1.4 1 1 0 1 1 1 0 ATP11 protein DUF3810 PF12725.7 KOG98968.1 - 7.9 5.7 7.9 8.9 5.6 7.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) T3SS_needle_F PF09392.10 KOG98968.1 - 8.4 6.7 11.1 7.7 6.8 1.9 3.0 2 1 1 3 3 3 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Chisel PF15355.6 KOG98969.1 - 0.028 14.7 0.2 0.079 13.2 0.1 1.8 2 0 0 2 2 2 0 Stretch-responsive small skeletal muscle X protein, Chisel DUF1751 PF08551.10 KOG98970.1 - 3.2e-31 107.8 1.1 3.2e-31 107.8 1.1 2.3 3 0 0 3 3 3 1 Eukaryotic integral membrane protein (DUF1751) DUF2157 PF09925.9 KOG98970.1 - 0.023 14.5 3.8 0.29 10.9 3.9 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF3566 PF12089.8 KOG98970.1 - 3.8 7.9 8.0 14 6.1 0.8 2.8 3 0 0 3 3 3 0 Transmembrane domain of unknown function (DUF3566) WSC PF01822.19 KOG98971.1 - 1.3e-10 41.4 11.3 1.3e-10 41.4 11.3 2.5 2 1 0 2 2 2 1 WSC domain Syndecan PF01034.20 KOG98971.1 - 4.1e-06 26.6 0.0 1.1e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Syndecan domain SKG6 PF08693.10 KOG98971.1 - 0.00092 18.6 1.5 0.0039 16.6 1.5 2.2 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Podoplanin PF05808.11 KOG98971.1 - 0.0064 16.6 4.8 0.0064 16.6 4.8 3.3 1 1 2 3 3 3 1 Podoplanin SWI-SNF_Ssr4 PF08549.10 KOG98971.1 - 2.5 6.6 13.0 3.5 6.1 13.0 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) TNF PF00229.18 KOG98971.1 - 7.7 6.5 7.9 0.86 9.6 0.6 2.6 2 1 0 2 2 2 0 TNF(Tumour Necrosis Factor) family Sugar_tr PF00083.24 KOG98973.1 - 1.2e-136 456.2 30.4 1.5e-136 455.9 30.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG98973.1 - 1.4e-28 99.9 34.8 2.5e-26 92.5 26.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 KOG98973.1 - 1.1e-06 27.4 1.6 1.1e-06 27.4 1.6 1.9 2 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 KOG98973.1 - 0.0017 16.9 0.4 0.0017 16.9 0.4 1.9 2 0 0 2 2 2 1 Transmembrane secretion effector CKAP2_C PF15297.6 KOG98973.1 - 0.22 10.6 2.9 0.4 9.7 2.9 1.3 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus PTS_2-RNA PF01885.16 KOG98974.1 - 2.4e-58 197.2 0.8 2.9e-58 196.9 0.8 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family PARP PF00644.20 KOG98974.1 - 0.11 12.1 0.1 0.2 11.2 0.1 1.5 1 1 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain HlyIII PF03006.20 KOG98975.1 - 9.3e-15 54.9 21.9 2.1e-14 53.8 22.0 1.5 1 1 1 2 2 2 1 Haemolysin-III related Orf78 PF06024.12 KOG98975.1 - 0.37 11.1 0.0 0.37 11.1 0.0 3.9 2 1 3 5 5 5 0 Orf78 (ac78) E1-E2_ATPase PF00122.20 KOG98975.1 - 2.8 7.4 6.6 0.3 10.6 0.5 2.2 2 1 1 3 3 3 0 E1-E2 ATPase Pkinase PF00069.25 KOG98976.1 - 5.8e-61 206.2 0.0 5.8e-61 206.2 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG98976.1 - 1.5e-31 109.6 0.0 2.7e-31 108.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG98976.1 - 4.1e-06 26.3 0.0 1.1e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOG98976.1 - 0.00049 19.0 0.0 0.00049 19.0 0.0 3.7 4 0 0 4 4 4 1 Fungal protein kinase FTA2 PF13095.6 KOG98976.1 - 0.0093 15.6 1.2 0.52 9.9 0.0 3.1 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KOG98976.1 - 0.011 15.1 0.0 0.021 14.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOG98976.1 - 0.018 15.0 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_M16_C PF05193.21 KOG98977.1 - 2.2e-13 50.6 0.2 3.4e-12 46.7 0.0 2.9 3 1 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOG98977.1 - 1.7e-08 34.6 0.0 5.8e-08 32.8 0.0 1.9 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) IlvC PF01450.19 KOG98977.1 - 0.099 12.9 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain tRNA-synt_1b PF00579.25 KOG98978.1 - 4.4e-19 68.9 0.0 1.3e-12 47.7 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) Methyltransf_23 PF13489.6 KOG98979.1 - 5.6e-21 75.1 0.0 8e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOG98979.1 - 2e-15 57.2 0.0 4.1e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOG98979.1 - 7.6e-15 55.4 0.0 2.1e-14 54.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOG98979.1 - 1.1e-12 47.9 0.0 2.1e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOG98979.1 - 7.2e-12 45.9 0.0 1.8e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOG98979.1 - 3.8e-08 33.0 0.0 5.3e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 KOG98979.1 - 3e-07 30.3 0.0 4.5e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) PrmA PF06325.13 KOG98979.1 - 4.6e-07 29.5 0.0 6.5e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 KOG98979.1 - 1.1e-06 28.3 0.0 1.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 KOG98979.1 - 2.1e-05 24.2 0.1 6.1e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 KOG98979.1 - 0.00084 19.4 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 KOG98979.1 - 0.0016 18.4 0.0 0.0024 17.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 KOG98979.1 - 0.0017 17.5 0.0 0.0031 16.6 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase PCMT PF01135.19 KOG98979.1 - 0.031 14.0 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 KOG98979.1 - 0.039 12.9 0.0 0.062 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) CheR PF01739.18 KOG98979.1 - 0.077 12.5 0.0 1.1 8.7 0.0 2.2 1 1 0 2 2 2 0 CheR methyltransferase, SAM binding domain RrnaAD PF00398.20 KOG98979.1 - 0.1 11.6 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase UvrD-helicase PF00580.21 KOG98980.1 - 1.6e-38 133.0 4.0 1.5e-19 70.7 0.6 2.7 2 1 1 3 3 3 2 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 KOG98980.1 - 1.2e-31 110.0 0.0 2.8e-31 108.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD_C PF13361.6 KOG98980.1 - 3.4e-27 95.8 0.0 1.6e-26 93.6 0.0 2.1 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 KOG98980.1 - 8.8e-13 47.9 0.0 2.1e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 KOG98980.1 - 1.4e-10 41.3 0.2 0.00028 20.7 0.0 3.1 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 KOG98980.1 - 5.3e-09 36.3 0.1 2.2e-07 30.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOG98980.1 - 0.00046 20.0 0.0 0.11 12.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 KOG98980.1 - 0.016 15.5 0.0 2.4 8.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 KOG98980.1 - 0.076 12.2 1.3 1.1 8.4 0.0 2.9 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) Rep_fac_C PF08542.11 KOG98981.1 - 3.8e-21 75.3 0.2 2.6e-20 72.6 0.1 2.3 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 KOG98981.1 - 2.1e-14 53.7 0.1 1.1e-10 41.5 0.0 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 KOG98981.1 - 3.5e-13 50.1 0.0 7.2e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOG98981.1 - 8.4e-08 32.8 0.0 3.1e-05 24.4 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 KOG98981.1 - 4.1e-07 30.1 0.0 3.8e-06 27.0 0.0 2.2 1 1 0 2 2 2 1 Rad17 P-loop domain AAA_14 PF13173.6 KOG98981.1 - 2.6e-06 27.5 0.0 4.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOG98981.1 - 1.9e-05 24.9 0.1 0.011 16.0 0.1 2.4 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KOG98981.1 - 4.1e-05 23.4 0.0 0.00015 21.6 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TniB PF05621.11 KOG98981.1 - 0.00016 21.2 0.2 0.57 9.6 0.0 2.5 2 0 0 2 2 2 2 Bacterial TniB protein AAA_3 PF07726.11 KOG98981.1 - 0.00016 21.5 0.0 0.00039 20.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 KOG98981.1 - 0.00025 20.9 0.0 0.0005 19.9 0.0 1.5 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 KOG98981.1 - 0.0027 17.1 0.1 0.042 13.2 0.1 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 KOG98981.1 - 0.0035 17.3 0.1 0.034 14.0 0.1 2.2 1 1 1 2 2 2 1 NTPase AAA_assoc_2 PF16193.5 KOG98981.1 - 0.006 16.9 0.0 0.018 15.3 0.0 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_24 PF13479.6 KOG98981.1 - 0.011 15.5 0.0 0.026 14.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 KOG98981.1 - 0.024 13.6 0.1 0.17 10.8 0.0 2.2 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_19 PF13245.6 KOG98981.1 - 0.025 14.9 0.2 0.41 11.0 0.1 2.4 1 1 0 2 2 2 0 AAA domain DNA_pol3_delta PF06144.13 KOG98981.1 - 0.032 14.0 0.6 0.054 13.3 0.6 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit NB-ARC PF00931.22 KOG98981.1 - 0.037 13.2 0.0 0.069 12.3 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain FtsK_SpoIIIE PF01580.18 KOG98981.1 - 0.038 13.3 0.0 0.075 12.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_30 PF13604.6 KOG98981.1 - 0.043 13.5 0.0 0.11 12.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 KOG98981.1 - 0.05 13.4 0.2 0.063 13.1 0.2 1.4 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOG98981.1 - 0.12 12.9 0.0 0.23 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOG98981.1 - 0.12 12.2 0.1 0.48 10.3 0.1 1.9 1 1 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 KOG98981.1 - 0.15 12.4 0.1 0.31 11.4 0.1 1.7 1 1 0 1 1 1 0 RNA helicase tRNA_m1G_MT PF01746.21 KOG98982.1 - 5.2e-47 160.1 0.1 8.7e-47 159.4 0.1 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase PQ-loop PF04193.14 KOG98983.1 - 1.4e-38 130.5 22.9 1e-20 73.3 3.5 2.9 3 0 0 3 3 3 2 PQ loop repeat SlyX PF04102.12 KOG98984.1 - 1.3 9.7 13.9 3 8.5 0.8 4.7 3 1 2 5 5 5 0 SlyX DUF1664 PF07889.12 KOG98984.1 - 8.5 6.4 17.0 0.28 11.2 2.2 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) MutS_V PF00488.21 KOG98985.1 - 2.8e-85 285.1 0.2 6.3e-85 284.0 0.2 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KOG98985.1 - 5.2e-33 114.9 0.7 5.2e-33 114.9 0.7 2.5 3 0 0 3 3 3 1 MutS domain III MutS_II PF05188.17 KOG98985.1 - 2.5e-25 89.3 0.2 8.9e-25 87.6 0.1 2.1 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 KOG98985.1 - 1.7e-19 69.9 0.9 5.3e-19 68.4 0.9 1.9 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.20 KOG98985.1 - 1.4e-09 38.2 0.2 7.7e-09 35.8 0.0 2.2 2 0 0 2 2 2 1 MutS domain I Fungal_trans PF04082.18 KOG98986.1 - 2.2e-40 138.4 5.4 2.2e-40 138.4 5.4 3.1 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG98986.1 - 6.7e-09 35.7 13.6 1.3e-08 34.8 13.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2935 PF11155.8 KOG98986.1 - 0.088 13.1 0.5 0.75 10.1 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) Mit_KHE1 PF10173.9 KOG98986.1 - 0.66 10.0 6.2 0.93 9.6 1.9 2.7 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related Thioredoxin PF00085.20 KOG98987.1 - 1.4e-10 41.1 0.1 3.7e-10 39.7 0.1 1.6 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 KOG98987.1 - 0.074 13.4 0.1 0.23 11.8 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin-like ERp29 PF07749.12 KOG98987.1 - 0.11 13.5 1.5 0.74 10.8 0.1 2.3 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain AhpC-TSA PF00578.21 KOG98987.1 - 0.15 11.9 1.1 0.21 11.5 0.1 1.7 2 0 0 2 2 2 0 AhpC/TSA family DUF3337 PF11816.8 KOG98988.1 - 4.9e-30 104.7 2.2 1.4e-28 99.9 2.2 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 KOG98988.1 - 8.8e-05 23.2 2.4 1.3 10.0 0.1 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat RAWUL PF16207.5 KOG98988.1 - 0.003 18.2 0.1 0.0098 16.5 0.1 1.9 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like CENP-S PF15630.6 KOG98989.1 - 9.8e-22 77.1 0.0 1.2e-21 76.8 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 KOG98989.1 - 1.4e-09 38.0 0.1 1.5e-09 37.9 0.1 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 KOG98989.1 - 0.0014 18.6 0.0 0.0021 18.0 0.0 1.4 1 1 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 KOG98989.1 - 0.0097 16.0 0.0 0.011 15.7 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit ADH_N PF08240.12 KOG98990.1 - 1.7e-29 101.9 0.5 5.4e-29 100.3 0.5 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOG98990.1 - 3.8e-25 88.4 1.5 5.8e-25 87.8 1.5 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOG98990.1 - 2.7e-05 25.2 0.0 4.6e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ELFV_dehydrog PF00208.21 KOG98990.1 - 0.027 14.2 0.5 0.045 13.5 0.5 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase RSN1_7TM PF02714.15 KOG98991.1 - 1.9e-87 293.1 23.0 1.9e-87 293.1 23.0 1.6 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 KOG98991.1 - 2.1e-41 141.3 1.8 2.1e-41 141.3 1.8 2.9 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 KOG98991.1 - 1.9e-24 85.6 0.1 5e-24 84.3 0.1 1.8 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter PHM7_cyt PF14703.6 KOG98991.1 - 2e-22 80.3 0.2 3.6e-22 79.4 0.2 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter ATG19_autophagy PF12744.7 KOG98992.1 - 1.3e-64 217.7 0.1 3.2e-64 216.5 0.0 1.7 2 0 0 2 2 2 1 Autophagy protein Atg19, Atg8-binding CRISPR_Cse1 PF09481.10 KOG98992.1 - 0.14 11.2 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) ATG19_autophagy PF12744.7 KOG98993.1 - 7.2e-58 195.7 1.4 2.3e-57 194.0 0.2 2.3 2 1 0 2 2 2 1 Autophagy protein Atg19, Atg8-binding Snapin_Pallidin PF14712.6 KOG98993.1 - 0.082 13.3 1.4 0.37 11.2 0.1 2.2 2 0 0 2 2 2 0 Snapin/Pallidin RasGAP PF00616.19 KOG98994.1 - 1e-26 94.0 7.0 4.6e-18 65.7 0.8 3.5 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase RNase_T PF00929.24 KOG98995.1 - 3.5e-17 63.4 0.1 7.8e-17 62.3 0.0 1.6 2 0 0 2 2 2 1 Exonuclease DNA_pol_A_exo1 PF01612.20 KOG98995.1 - 0.0041 16.9 0.0 0.015 15.0 0.0 2.0 1 1 0 1 1 1 1 3'-5' exonuclease CRIM PF16978.5 KOG98996.1 - 1.7e-34 119.0 2.1 1.4e-33 116.0 0.8 2.8 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 KOG98996.1 - 1.8e-29 102.2 0.3 1.8e-29 102.2 0.3 3.4 4 0 0 4 4 4 2 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology TUG-UBL1 PF11470.8 KOG98996.1 - 0.0019 18.4 1.3 0.086 13.1 0.1 3.0 3 0 0 3 3 3 1 TUG ubiquitin-like domain RBD PF02196.15 KOG98996.1 - 0.01 15.9 0.0 0.029 14.4 0.0 1.8 1 0 0 1 1 1 0 Raf-like Ras-binding domain LVIVD PF08309.11 KOG98996.1 - 0.066 12.5 0.0 3.2 7.1 0.1 2.7 2 0 0 2 2 2 0 LVIVD repeat ATP19 PF11022.8 KOG98997.1 - 1e-22 80.2 0.0 1.2e-22 80.1 0.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit K Brix PF04427.18 KOG98998.1 - 7.6e-41 140.3 0.1 1.1e-40 139.8 0.1 1.2 1 0 0 1 1 1 1 Brix domain NatB_MDM20 PF09797.9 KOG98999.1 - 4.1e-47 160.9 8.4 3.5e-46 157.9 8.4 2.5 1 1 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_7 PF13176.6 KOG98999.1 - 0.041 13.9 0.0 0.18 11.9 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TFIIA_gamma_N PF02268.16 KOG98999.1 - 0.14 12.2 1.0 3.2 7.8 0.1 2.8 2 0 0 2 2 2 0 Transcription initiation factor IIA, gamma subunit, helical domain Ribosomal_60s PF00428.19 KOG98999.1 - 0.21 12.2 0.1 0.55 10.9 0.1 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein ENT PF03735.14 KOG98999.1 - 0.74 9.9 3.0 13 6.0 0.1 3.0 3 0 0 3 3 3 0 ENT domain ABC_tran PF00005.27 KOG99000.1 - 4.2e-50 169.8 2.8 5.9e-24 85.1 0.0 2.8 3 0 0 3 3 2 2 ABC transporter ABC2_membrane PF01061.24 KOG99000.1 - 1.3e-40 139.1 35.5 2e-24 86.2 14.9 2.4 2 0 0 2 2 2 2 ABC-2 type transporter AAA_21 PF13304.6 KOG99000.1 - 6.4e-11 42.6 13.3 0.00012 22.0 0.1 4.8 3 2 1 5 5 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOG99000.1 - 1.8e-09 37.4 1.7 3.3e-05 23.4 0.1 3.1 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KOG99000.1 - 4.6e-09 36.4 3.5 0.00026 20.9 0.0 2.7 3 0 0 3 3 2 2 RsgA GTPase AAA_16 PF13191.6 KOG99000.1 - 2.2e-07 31.4 0.4 0.014 15.8 0.0 3.1 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 KOG99000.1 - 2.5e-07 31.0 0.3 0.011 16.0 0.0 3.8 3 1 0 3 3 3 2 AAA domain AAA_29 PF13555.6 KOG99000.1 - 2.6e-06 27.0 2.4 0.063 13.0 0.1 3.0 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.6 KOG99000.1 - 1.5e-05 24.6 0.1 0.04 13.5 0.0 4.0 4 0 0 4 4 4 1 AAA domain AAA_18 PF13238.6 KOG99000.1 - 4.7e-05 23.9 0.1 0.34 11.5 0.0 2.9 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 KOG99000.1 - 9.4e-05 22.4 0.1 0.049 13.6 0.1 2.6 2 0 0 2 2 2 1 NACHT domain T2SSE PF00437.20 KOG99000.1 - 0.00046 19.3 0.2 0.13 11.3 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_28 PF13521.6 KOG99000.1 - 0.00059 20.1 0.4 0.085 13.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 KOG99000.1 - 0.0016 18.5 3.3 0.27 11.3 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 KOG99000.1 - 0.0018 18.7 0.3 2 8.9 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_30 PF13604.6 KOG99000.1 - 0.0018 18.0 0.5 0.62 9.8 0.2 2.4 2 0 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 KOG99000.1 - 0.004 16.6 0.2 0.055 12.9 0.1 2.3 2 0 0 2 2 2 1 Poxvirus A32 protein ATPase_2 PF01637.18 KOG99000.1 - 0.0051 16.7 0.2 1.1 9.1 0.0 2.8 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 KOG99000.1 - 0.0053 16.0 0.1 1.5 8.0 0.0 2.4 2 0 0 2 2 2 1 KAP family P-loop domain AAA PF00004.29 KOG99000.1 - 0.0096 16.3 1.2 4.1 7.8 0.0 3.6 4 1 0 4 4 2 1 ATPase family associated with various cellular activities (AAA) Cytidylate_kin PF02224.18 KOG99000.1 - 0.012 15.3 0.9 0.51 10.0 0.0 2.8 3 0 0 3 3 2 0 Cytidylate kinase AAA_24 PF13479.6 KOG99000.1 - 0.013 15.3 1.1 4.6 6.9 0.4 2.4 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 KOG99000.1 - 0.013 14.7 0.0 0.82 8.8 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain AAA_19 PF13245.6 KOG99000.1 - 0.015 15.6 0.1 0.48 10.7 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 KOG99000.1 - 0.016 15.6 0.2 4.6 7.7 0.2 2.9 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 KOG99000.1 - 0.019 14.9 0.2 13 5.7 0.1 3.3 3 0 0 3 3 3 0 NTPase Adeno_IVa2 PF02456.15 KOG99000.1 - 0.021 13.7 0.3 0.046 12.5 0.0 1.6 2 0 0 2 2 2 0 Adenovirus IVa2 protein cobW PF02492.19 KOG99000.1 - 0.029 13.9 1.3 2 8.0 0.3 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 KOG99000.1 - 0.04 14.0 0.1 9.3 6.3 0.0 3.0 3 0 0 3 3 2 0 AAA domain SbcCD_C PF13558.6 KOG99000.1 - 0.047 13.9 0.6 22 5.4 0.0 3.5 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 KOG99000.1 - 0.05 14.1 13.1 0.068 13.7 0.4 3.6 3 1 1 4 4 2 0 AAA domain AAA_5 PF07728.14 KOG99000.1 - 0.053 13.5 0.6 1.9 8.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) FtsK_SpoIIIE PF01580.18 KOG99000.1 - 0.061 12.7 2.0 0.81 9.0 0.4 2.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family PRK PF00485.18 KOG99000.1 - 0.063 13.0 0.9 6.8 6.4 0.1 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Siah-Interact_N PF09032.11 KOG99000.1 - 0.085 13.2 0.2 0.24 11.7 0.2 1.7 1 0 0 1 1 1 0 Siah interacting protein, N terminal dNK PF01712.19 KOG99000.1 - 0.099 12.5 0.0 8.6 6.2 0.0 2.6 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_33 PF13671.6 KOG99000.1 - 0.12 12.5 0.3 12 6.0 0.2 2.6 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 KOG99000.1 - 0.16 11.3 0.6 1.2 8.5 0.1 2.6 3 0 0 3 3 3 0 KaiC Zeta_toxin PF06414.12 KOG99000.1 - 0.18 11.1 0.4 4.3 6.5 0.1 2.3 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.17 KOG99000.1 - 0.2 11.7 12.3 2.1 8.4 0.6 4.0 2 1 2 4 4 4 0 Helicase HerA, central domain Wbp11 PF09429.10 KOG99000.1 - 0.3 11.5 3.2 0.78 10.2 3.2 1.7 1 0 0 1 1 1 0 WW domain binding protein 11 ATP_bind_1 PF03029.17 KOG99000.1 - 0.74 9.5 3.4 19 4.9 1.2 2.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PCI PF01399.27 KOG99002.1 - 2.4e-19 69.8 0.2 5e-18 65.5 0.0 2.7 2 0 0 2 2 2 1 PCI domain Dynein_heavy PF03028.15 KOG99002.1 - 0.13 12.3 0.4 0.38 10.9 0.4 1.7 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain Sdh5 PF03937.16 KOG99003.1 - 9.3e-27 92.8 0.9 1.6e-26 92.1 0.9 1.4 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase CAMSAP_CC1 PF17095.5 KOG99004.1 - 0.025 14.4 0.0 0.061 13.2 0.0 1.6 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin Nuf2 PF03800.14 KOG99005.1 - 9e-45 152.2 3.5 9e-45 152.2 3.5 2.0 2 0 0 2 2 2 1 Nuf2 family SIR2 PF02146.17 KOG99006.1 - 2.5e-66 222.9 0.0 3.9e-66 222.3 0.0 1.3 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 KOG99006.1 - 3.6e-56 189.2 3.7 6.6e-56 188.3 3.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 KOG99006.1 - 0.00076 19.2 0.1 0.32 10.7 0.0 2.7 3 0 0 3 3 3 2 Thiamine pyrophosphate enzyme, central domain HLH PF00010.26 KOG99007.1 - 3.7e-17 62.0 0.0 6e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Inv-AAD PF18785.1 KOG99008.1 - 3.5e-40 136.9 0.0 5.6e-40 136.2 0.0 1.3 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase PseudoU_synth_2 PF00849.22 KOG99008.1 - 3.2e-32 111.8 0.1 7.1e-32 110.7 0.1 1.6 1 0 0 1 1 1 1 RNA pseudouridylate synthase dCMP_cyt_deam_1 PF00383.23 KOG99008.1 - 3.3e-18 65.4 0.7 5.3e-18 64.8 0.1 1.7 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KOG99008.1 - 4.6e-05 23.2 0.0 8.6e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 MafB19-like deaminase Exo_endo_phos PF03372.23 KOG99009.1 - 2.4e-11 43.6 0.0 3.6e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Inositol_P PF00459.25 KOG99010.1 - 9.5e-66 222.1 0.1 4.9e-64 216.5 0.1 2.0 1 1 0 1 1 1 1 Inositol monophosphatase family CRT10 PF08728.10 KOG99011.1 - 7.5e-265 880.6 3.9 8.6e-265 880.4 3.9 1.0 1 0 0 1 1 1 1 CRT10 FAST_2 PF08368.12 KOG99011.1 - 0.1 13.4 0.2 12 6.7 0.0 2.6 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 2 Adap_comp_sub PF00928.21 KOG99012.1 - 8.8e-78 261.3 1.1 1.3e-77 260.7 1.1 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KOG99012.1 - 0.00055 19.9 0.3 0.0037 17.2 0.1 2.1 2 0 0 2 2 2 1 Clathrin adaptor complex small chain muHD PF10291.9 KOG99012.1 - 0.045 13.2 0.0 0.066 12.6 0.0 1.3 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain Pribosyl_synth PF14572.6 KOG99013.1 - 1.7e-41 142.3 1.8 1.4e-40 139.3 1.8 2.1 1 1 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 KOG99013.1 - 2.6e-35 120.9 0.1 1.2e-34 118.7 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 KOG99013.1 - 1.3e-12 47.5 0.5 2.2e-07 30.5 0.2 2.5 2 0 0 2 2 2 2 Phosphoribosyl transferase domain DUF21 PF01595.20 KOG99014.1 - 1.2e-33 116.3 2.1 1.5e-33 116.0 0.7 1.8 2 0 0 2 2 2 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 KOG99014.1 - 3.4e-05 24.2 0.0 0.17 12.3 0.1 2.8 2 0 0 2 2 2 2 CBS domain NAD_Gly3P_dh_N PF01210.23 KOG99015.1 - 4.4e-53 179.5 0.0 7.1e-53 178.8 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 KOG99015.1 - 9.7e-41 139.4 0.2 1.5e-40 138.7 0.2 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 KOG99015.1 - 0.048 14.2 0.0 3.6 8.2 0.0 2.6 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 KOG99015.1 - 0.11 12.4 0.0 4.3 7.2 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Arginosuc_synth PF00764.19 KOG99016.1 - 6.2e-166 552.5 0.0 7.2e-166 552.3 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 KOG99016.1 - 0.0002 20.9 0.0 0.0004 19.9 0.0 1.5 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 KOG99016.1 - 0.0037 16.1 0.0 0.0056 15.5 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase Peptidase_M49 PF03571.15 KOG99017.1 - 1.3e-226 753.3 0.1 3.3e-226 751.9 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M49 Phos_pyr_kin PF08543.12 KOG99018.1 - 2e-78 263.2 0.1 2.5e-78 262.9 0.1 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 KOG99018.1 - 8.7e-70 234.8 0.4 1.1e-69 234.4 0.4 1.1 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 KOG99018.1 - 0.044 13.1 0.0 0.1 11.9 0.0 1.5 1 1 0 1 1 1 0 pfkB family carbohydrate kinase zf-C3HC4_4 PF15227.6 KOG99019.1 - 2.4e-09 37.2 10.8 2.4e-09 37.2 10.8 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 KOG99019.1 - 1.9e-08 34.0 9.8 1.9e-08 34.0 9.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOG99019.1 - 3e-08 33.4 13.3 7e-08 32.2 5.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOG99019.1 - 6.7e-08 32.4 6.8 6.7e-08 32.4 6.8 1.9 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KOG99019.1 - 4.5e-07 30.1 8.9 4.5e-07 30.1 8.9 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOG99019.1 - 4.4e-06 26.4 9.8 4.4e-06 26.4 9.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOG99019.1 - 3.8e-05 23.5 8.5 3.8e-05 23.5 8.5 2.5 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KOG99019.1 - 0.00045 20.0 6.3 0.00045 20.0 6.3 2.5 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zinc_ribbon_2 PF13240.6 KOG99019.1 - 0.002 17.8 3.2 0.11 12.2 1.0 3.6 2 1 1 3 3 3 1 zinc-ribbon domain HypA PF01155.19 KOG99019.1 - 0.0036 17.3 6.3 0.099 12.7 0.1 2.3 1 1 1 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 KOG99019.1 - 0.024 14.7 10.2 0.27 11.3 0.2 2.6 2 0 0 2 2 2 0 Double zinc ribbon zf-rbx1 PF12678.7 KOG99019.1 - 0.11 12.8 11.0 0.039 14.2 6.4 2.4 2 0 0 2 2 2 0 RING-H2 zinc finger domain zinc-ribbons_6 PF07191.12 KOG99019.1 - 0.12 12.4 7.9 3 7.9 0.1 2.5 2 1 0 2 2 2 0 zinc-ribbons PhnA_Zn_Ribbon PF08274.12 KOG99019.1 - 0.34 10.9 6.1 9.8 6.2 0.0 4.0 4 0 0 4 4 4 0 PhnA Zinc-Ribbon zinc_ribbon_9 PF14369.6 KOG99019.1 - 0.51 10.6 18.3 0.44 10.9 2.9 3.5 3 1 0 3 3 2 0 zinc-ribbon Zn-ribbon_8 PF09723.10 KOG99019.1 - 0.8 9.9 10.1 5.2 7.3 1.1 2.9 2 1 0 2 2 2 0 Zinc ribbon domain zf-ANAPC11 PF12861.7 KOG99019.1 - 0.85 9.7 8.0 0.058 13.4 2.6 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RRN7 PF11781.8 KOG99019.1 - 1.5 8.6 8.2 8.5 6.2 0.3 3.7 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Cytochrom_c3_2 PF14537.6 KOG99019.1 - 2.5 8.6 7.4 3.6 8.1 0.1 3.4 2 1 0 2 2 2 0 Cytochrome c3 zf-ribbon_3 PF13248.6 KOG99019.1 - 4 7.0 9.8 14 5.2 5.4 3.3 2 1 0 2 2 2 0 zinc-ribbon domain Cytochrome_C7 PF14522.6 KOG99019.1 - 4.6 7.3 9.7 6.9 6.8 0.4 3.0 2 1 0 2 2 2 0 Cytochrome c7 and related cytochrome c zf-RING_4 PF14570.6 KOG99019.1 - 9 6.2 19.3 3.8 7.4 8.6 3.3 2 2 0 2 2 2 0 RING/Ubox like zinc-binding domain Colicin_V PF02674.16 KOG99020.1 - 0.08 12.9 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Colicin V production protein Ribosomal_S19 PF00203.21 KOG99020.1 - 0.084 12.8 1.1 14 5.6 0.0 3.2 2 1 1 3 3 3 0 Ribosomal protein S19 SAM_decarbox PF01536.16 KOG99022.1 - 1.7e-126 422.0 3.7 1.9e-126 421.8 3.7 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Tfb5 PF06331.12 KOG99022.1 - 0.045 13.7 0.1 0.51 10.4 0.0 2.5 2 0 0 2 2 2 0 Transcription factor TFIIH complex subunit Tfb5 Gal11_ABD1 PF18535.1 KOG99023.1 - 6.5e-39 131.9 19.8 6.5e-39 131.9 19.8 8.2 4 3 1 5 5 5 1 Gal11 activator-binding domain (ABD1) Med15_fungi PF05397.12 KOG99023.1 - 4.2e-32 110.8 4.8 4.2e-32 110.8 4.8 7.5 5 4 1 6 6 6 1 Mediator complex subunit 15 KIX_2 PF16987.5 KOG99023.1 - 8.3e-18 64.2 0.6 8.3e-18 64.2 0.6 6.7 5 3 0 5 5 5 1 KIX domain GSH_synth_ATP PF03917.17 KOG99024.1 - 7.6e-127 423.1 0.1 8.7e-127 422.9 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 KOG99024.1 - 4.1e-32 110.7 0.1 8.8e-32 109.6 0.1 1.6 1 0 0 1 1 1 1 Eukaryotic glutathione synthase PilO PF04350.13 KOG99024.1 - 0.059 13.5 0.3 0.65 10.2 0.0 2.5 3 0 0 3 3 3 0 Pilus assembly protein, PilO CppA_C PF14507.6 KOG99024.1 - 0.06 14.1 0.7 0.2 12.4 0.7 1.8 1 0 0 1 1 1 0 CppA C-terminal Pkinase PF00069.25 KOG99025.1 - 6.6e-61 206.0 0.1 1.3e-60 205.0 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99025.1 - 2.5e-22 79.4 0.0 4.3e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG99025.1 - 4.3e-10 39.4 0.0 7.5e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PAS PF00989.25 KOG99025.1 - 9.6e-05 22.4 0.0 0.77 9.8 0.0 2.6 2 0 0 2 2 2 2 PAS fold Pkinase_fungal PF17667.1 KOG99025.1 - 0.0037 16.1 0.0 0.011 14.6 0.0 1.7 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOG99025.1 - 0.0061 16.5 0.2 0.016 15.2 0.2 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KOG99025.1 - 0.0069 15.8 0.1 0.013 14.8 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KOG99025.1 - 0.06 13.0 0.1 0.18 11.4 0.1 1.8 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 HhH-GPD PF00730.25 KOG99027.1 - 4.6e-22 78.5 0.0 7.5e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 KOG99027.1 - 0.0014 18.4 0.0 0.0084 15.9 0.0 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix motif Exo_endo_phos PF03372.23 KOG99028.1 - 5.9e-14 52.1 1.0 1.7e-13 50.6 1.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RRM_1 PF00076.22 KOG99029.1 - 1.9e-19 69.3 2.2 6.2e-14 51.6 0.1 4.7 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOG99029.1 - 0.003 17.6 1.4 0.35 11.0 0.0 3.3 2 1 0 2 2 2 1 RNA recognition motif Nup35_RRM_2 PF14605.6 KOG99029.1 - 0.0039 17.2 0.0 0.33 11.0 0.0 2.8 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Ribosomal_S19 PF00203.21 KOG99030.1 - 4.6e-33 112.9 0.2 2.7e-32 110.5 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein S19 DUF86 PF01934.17 KOG99030.1 - 0.16 11.8 0.0 3.2 7.7 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF86 Ribosomal_60s PF00428.19 KOG99031.1 - 1.4e-24 86.5 13.5 1.6e-24 86.3 13.5 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Sugar-bind PF04198.13 KOG99031.1 - 0.0056 15.8 0.1 0.0071 15.5 0.1 1.2 1 0 0 1 1 1 1 Putative sugar-binding domain Proteasome PF00227.26 KOG99032.1 - 1.8e-57 193.9 0.0 2.4e-57 193.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOG99032.1 - 2.2e-13 49.6 0.2 5.9e-13 48.2 0.1 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature STAS PF01740.21 KOG99032.1 - 0.0066 16.1 0.2 0.018 14.7 0.1 1.8 2 0 0 2 2 2 1 STAS domain DUF956 PF06115.11 KOG99033.1 - 0.066 12.9 0.6 0.44 10.3 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF956) PSI_integrin PF17205.3 KOG99033.1 - 0.18 11.5 0.6 0.46 10.3 0.6 1.6 1 0 0 1 1 1 0 Integrin plexin domain DUF5558 PF17713.1 KOG99033.1 - 2.5 8.5 5.3 0.65 10.4 0.1 2.6 2 1 1 3 3 3 0 Family of unknown function (DUF5558) SMC_N PF02463.19 KOG99034.1 - 2.6e-28 99.0 0.0 5.2e-28 98.0 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOG99034.1 - 1.2e-17 65.0 20.9 1.2e-17 65.0 20.9 5.4 2 2 2 4 4 4 1 AAA domain AAA_29 PF13555.6 KOG99034.1 - 0.00039 20.1 0.0 0.00085 19.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Phe_tRNA-synt_N PF02912.18 KOG99034.1 - 0.00087 19.2 2.6 0.00087 19.2 2.6 4.4 5 1 0 5 5 5 1 Aminoacyl tRNA synthetase class II, N-terminal domain AAA_21 PF13304.6 KOG99034.1 - 0.0072 16.2 9.2 0.0072 16.2 0.0 3.3 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 KOG99034.1 - 0.035 13.7 0.2 0.24 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 KOG99034.1 - 0.054 13.4 0.1 0.18 11.7 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_27 PF13514.6 KOG99034.1 - 0.085 12.4 0.0 0.085 12.4 0.0 3.8 4 2 0 4 4 4 0 AAA domain tRNA-synt_1c PF00749.21 KOG99035.1 - 2.2e-118 394.7 0.0 2.9e-118 394.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain UBN_AB PF14075.6 KOG99035.1 - 0.074 12.8 0.0 2 8.1 0.0 2.4 2 0 0 2 2 2 0 Ubinuclein conserved middle domain DUF775 PF05603.12 KOG99036.1 - 2.4e-63 213.3 0.0 2.8e-63 213.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) SIL1 PF16782.5 KOG99037.1 - 6.2e-103 344.0 14.8 7.5e-103 343.7 14.8 1.1 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 Glyco_hydro_72 PF03198.14 KOG99038.1 - 1.1e-146 488.1 10.3 1.5e-146 487.6 10.3 1.2 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 KOG99038.1 - 3.2e-06 26.8 0.2 5.5e-05 22.7 0.2 2.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 KOG99038.1 - 0.0013 17.9 1.7 0.0034 16.5 1.7 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Nop14 PF04147.12 KOG99038.1 - 0.048 11.9 3.5 0.063 11.5 3.5 1.1 1 0 0 1 1 1 0 Nop14-like family Hid1 PF12722.7 KOG99038.1 - 0.28 9.2 2.2 0.33 9.0 2.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BUD22 PF09073.10 KOG99038.1 - 0.48 9.7 14.8 0.68 9.2 14.8 1.2 1 0 0 1 1 1 0 BUD22 Macoilin PF09726.9 KOG99038.1 - 0.71 8.4 13.8 0.94 8.0 13.8 1.1 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 KOG99038.1 - 3.6 6.4 17.3 5.2 5.8 17.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Tmemb_cc2 PF10267.9 KOG99038.1 - 5.1 6.1 6.5 7 5.7 6.5 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Peroxin-3 PF04882.12 KOG99038.1 - 7.6 5.4 9.7 10 5.0 9.7 1.1 1 0 0 1 1 1 0 Peroxin-3 Hap4_Hap_bind PF10297.9 KOG99039.1 - 1.3e-08 34.7 1.6 2.6e-08 33.7 1.6 1.6 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 KOG99039.1 - 1.9e-07 31.1 7.4 8.9e-07 28.9 7.4 2.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KOG99039.1 - 4.7e-05 23.4 6.3 0.00017 21.6 6.3 2.0 1 0 0 1 1 1 1 Basic region leucine zipper Tetraspanin PF00335.20 KOG99039.1 - 0.00089 19.0 0.0 1.7 8.3 0.0 2.2 1 1 1 2 2 2 1 Tetraspanin family bZIP_Maf PF03131.17 KOG99039.1 - 0.0086 16.6 8.0 0.017 15.6 7.3 1.9 1 1 0 1 1 1 1 bZIP Maf transcription factor ADIP PF11559.8 KOG99039.1 - 1 9.4 13.0 0.11 12.6 7.8 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.6 KOG99039.1 - 1.5 8.1 4.3 2.9 7.2 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Striatin PF08232.12 KOG99039.1 - 6 7.5 13.2 1.7 9.2 8.2 2.7 1 1 1 2 2 2 0 Striatin family LETM1 PF07766.13 KOG99040.1 - 9.3e-99 330.1 6.6 9.3e-99 330.1 6.6 1.7 2 0 0 2 2 2 1 LETM1-like protein DUF966 PF06136.13 KOG99040.1 - 1.9 8.1 16.0 4.4 6.9 16.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TOM13 PF08219.11 KOG99041.1 - 1.5e-25 88.9 0.0 2e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 Outer membrane protein TOM13 TIP120 PF08623.10 KOG99042.1 - 0.00046 20.0 2.4 0.00052 19.8 0.3 2.2 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) HEAT PF02985.22 KOG99042.1 - 0.15 12.4 0.0 0.62 10.5 0.0 2.2 1 0 0 1 1 1 0 HEAT repeat GTP_EFTU PF00009.27 KOG99044.1 - 3.3e-31 108.3 5.9 7.8e-30 103.9 4.5 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KOG99044.1 - 3e-26 91.6 0.6 8.6e-26 90.1 0.6 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 IF2_N PF04760.15 KOG99044.1 - 2e-09 37.1 0.0 6e-09 35.6 0.0 1.9 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region MMR_HSR1 PF01926.23 KOG99044.1 - 2.7e-09 37.1 0.4 9.4e-09 35.4 0.4 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG99044.1 - 0.0001 22.3 5.1 0.0045 16.9 1.0 2.8 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU_D2 PF03144.25 KOG99044.1 - 0.0015 18.9 0.3 0.78 10.2 0.1 3.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 FeoB_N PF02421.18 KOG99044.1 - 0.0016 18.0 0.6 0.0058 16.2 0.6 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 KOG99044.1 - 0.003 17.0 0.1 0.0078 15.7 0.1 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 KOG99044.1 - 0.0035 17.0 1.2 0.0065 16.1 0.1 2.1 2 1 0 2 2 2 1 Ras family GTP_EFTU_D4 PF14578.6 KOG99044.1 - 0.057 13.3 1.0 0.32 10.9 0.1 2.5 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Dynamin_N PF00350.23 KOG99044.1 - 0.42 10.6 7.5 9.4 6.3 0.0 3.9 4 1 1 5 5 5 0 Dynamin family PDCD2_C PF04194.13 KOG99045.1 - 5.9e-39 133.9 1.9 5.2e-38 130.8 0.0 2.7 3 0 0 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain RNB PF00773.19 KOG99046.1 - 1.5e-97 326.9 0.1 2.3e-97 326.2 0.1 1.3 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 KOG99046.1 - 5.1e-96 318.3 0.2 1.3e-95 316.9 0.2 1.8 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 KOG99046.1 - 8e-31 105.9 0.2 2.2e-30 104.5 0.2 1.8 1 0 0 1 1 1 1 S1 domain OB_Dis3 PF17849.1 KOG99046.1 - 3.7e-17 62.1 0.0 1.1e-16 60.6 0.0 1.9 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 KOG99046.1 - 1.6e-15 57.6 0.3 3.9e-15 56.3 0.3 1.6 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 KOG99046.1 - 0.00011 22.3 0.0 0.008 16.3 0.0 3.1 2 0 0 2 2 2 1 Cold shock domain Dis3l2_C_term PF17877.1 KOG99046.1 - 0.077 13.3 0.1 0.077 13.3 0.1 1.9 2 0 0 2 2 2 0 DIS3-like exonuclease 2 C terminal AA_permease PF00324.21 KOG99047.1 - 8.5e-122 407.1 41.5 1.1e-121 406.8 41.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG99047.1 - 3.1e-32 112.0 43.2 3.9e-32 111.6 43.2 1.2 1 0 0 1 1 1 1 Amino acid permease SUR7 PF06687.12 KOG99048.1 - 4.1e-17 62.5 18.4 8e-17 61.6 18.4 1.4 1 0 0 1 1 1 1 SUR7/PalI family EMP70 PF02990.16 KOG99048.1 - 2.5 6.7 8.0 4.2 5.9 8.0 1.3 1 0 0 1 1 1 0 Endomembrane protein 70 SNARE PF05739.19 KOG99049.1 - 6.2e-17 61.3 2.2 3.8e-16 58.8 0.4 2.3 2 0 0 2 2 2 1 SNARE domain DUF1980 PF09323.10 KOG99049.1 - 0.00014 21.9 1.2 0.00041 20.3 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1980) GRA6 PF05084.13 KOG99049.1 - 0.009 16.0 0.9 0.016 15.2 0.9 1.4 1 0 0 1 1 1 1 Granule antigen protein (GRA6) DUF2615 PF11027.8 KOG99049.1 - 0.024 14.8 0.1 0.058 13.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) DUF4834 PF16118.5 KOG99049.1 - 3.8 8.5 8.5 0.14 13.2 0.7 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4834) WHIM1 PF15612.6 KOG99050.1 - 0.00012 21.5 0.0 0.00029 20.3 0.0 1.6 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 Pkinase PF00069.25 KOG99051.1 - 2.3e-70 237.0 0.0 4.1e-70 236.2 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99051.1 - 1.2e-38 132.9 0.0 2e-38 132.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG99051.1 - 8e-05 22.1 0.0 0.0013 18.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOG99051.1 - 0.029 13.2 0.6 0.073 11.8 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase zf-RING_2 PF13639.6 KOG99054.1 - 7.3e-10 39.0 7.5 1.6e-09 37.9 7.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KOG99054.1 - 7.8e-08 32.5 9.2 1.6e-07 31.5 9.2 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KOG99054.1 - 1.5e-07 31.2 4.8 2.7e-07 30.4 4.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOG99054.1 - 6.5e-06 26.1 3.8 1.6e-05 24.9 3.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KOG99054.1 - 1.1e-05 25.2 5.9 3.6e-05 23.5 5.9 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOG99054.1 - 5.7e-05 22.9 8.0 5.7e-05 22.9 8.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOG99054.1 - 6.2e-05 22.8 4.9 0.00013 21.8 4.9 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 KOG99054.1 - 0.00038 20.0 0.4 0.00093 18.8 0.4 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 KOG99054.1 - 0.00048 19.9 10.4 0.0065 16.3 10.4 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KOG99054.1 - 0.025 14.7 1.4 0.025 14.7 1.4 2.8 3 0 0 3 3 2 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 KOG99054.1 - 0.079 13.0 4.7 0.2 11.7 4.6 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.11 KOG99054.1 - 0.25 11.7 1.7 0.54 10.6 1.7 1.6 1 0 0 1 1 1 0 RING-like domain CTU2 PF10288.9 KOG99054.1 - 0.57 10.4 11.6 0.46 10.7 5.3 2.9 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-P11 PF03854.14 KOG99054.1 - 1.2 8.9 6.1 0.22 11.2 2.0 1.9 2 0 0 2 2 2 0 P-11 zinc finger zf-RING_11 PF17123.5 KOG99054.1 - 1.3 8.8 8.0 2 8.2 3.7 2.8 2 1 0 2 2 2 0 RING-like zinc finger FANCL_C PF11793.8 KOG99054.1 - 1.9 8.7 5.8 2.1 8.6 3.9 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 KOG99054.1 - 2.6 8.2 8.6 9.5 6.4 8.5 2.0 1 1 0 1 1 1 0 RING-variant domain Histone PF00125.24 KOG99055.1 - 1.8e-16 60.7 0.0 2.3e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 KOG99055.1 - 2.1e-13 49.8 0.3 3.8e-13 48.9 0.3 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 KOG99055.1 - 0.00013 22.1 0.0 0.00018 21.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PLA2_B PF01735.18 KOG99056.1 - 1.6e-231 768.9 1.7 2e-231 768.7 1.7 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain IBR PF01485.21 KOG99056.1 - 0.063 13.5 1.3 0.13 12.5 1.3 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain RTC PF01137.21 KOG99057.1 - 1.4e-44 152.0 0.0 1.6e-44 151.8 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 KOG99057.1 - 5.6e-30 103.9 0.0 9.1e-30 103.2 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain MMM1 PF10296.9 KOG99058.1 - 1.1e-06 27.9 1.3 9.7e-05 21.6 1.3 2.5 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 Polyketide_cyc PF03364.20 KOG99059.1 - 3e-16 59.8 0.0 3.6e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport LapA_dom PF06305.11 KOG99060.1 - 0.027 14.3 0.3 0.049 13.5 0.3 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF3328 PF11807.8 KOG99060.1 - 4 7.1 5.8 6.7 6.4 1.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3328) Topoisom_I PF01028.20 KOG99061.1 - 3.6e-98 327.4 1.2 3.6e-98 327.4 1.2 2.9 3 1 1 4 4 4 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 KOG99061.1 - 4.9e-97 323.6 1.0 4.9e-97 323.6 1.0 3.4 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 KOG99061.1 - 1.1e-33 114.9 0.7 1.1e-33 114.9 0.7 2.3 2 0 0 2 2 2 1 C-terminal topoisomerase domain FlaC_arch PF05377.11 KOG99061.1 - 0.64 10.4 8.8 0.043 14.2 2.6 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) RNA_pol_L_2 PF13656.6 KOG99062.1 - 4.2e-25 87.3 0.0 5.7e-25 86.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 KOG99062.1 - 2e-09 36.7 0.0 4.5e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Thymidylate_kin PF02223.17 KOG99062.1 - 0.14 11.8 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Thymidylate kinase Sin3a_C PF16879.5 KOG99063.1 - 1.1e-76 258.3 4.5 1.1e-76 258.3 4.5 3.3 3 1 1 4 4 4 1 C-terminal domain of Sin3a protein PAH PF02671.21 KOG99063.1 - 3.5e-43 145.5 13.0 8e-18 64.3 2.5 4.9 4 0 0 4 4 4 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 KOG99063.1 - 2.1e-42 143.1 0.2 8.1e-42 141.3 0.2 2.1 1 0 0 1 1 1 1 Sin3 family co-repressor AAA_21 PF13304.6 KOG99063.1 - 0.45 10.3 9.0 0.21 11.4 2.2 3.4 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Cdh1_DBD_1 PF18196.1 KOG99063.1 - 2.5 8.5 6.9 20 5.5 6.9 2.7 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Bud13 PF09736.9 KOG99063.1 - 4.8 7.6 14.1 15 5.9 11.6 3.0 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex DHHC PF01529.20 KOG99064.1 - 1e-29 103.4 15.2 1e-29 103.4 15.2 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF3488 PF11992.8 KOG99064.1 - 0.25 10.2 2.8 0.48 9.3 2.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) HlyIII PF03006.20 KOG99065.1 - 2.5e-57 194.2 19.4 3e-57 193.9 19.4 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF1772 PF08592.11 KOG99065.1 - 3 8.1 5.7 1 9.7 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) Cyclin PF08613.11 KOG99066.1 - 4.8e-41 140.8 2.2 3.9e-40 137.8 2.2 2.2 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 KOG99066.1 - 0.068 12.9 0.4 0.12 12.2 0.0 1.6 2 0 0 2 2 2 0 Cyclin, N-terminal domain DNA_pol_A_exo1 PF01612.20 KOG99067.1 - 7.8e-48 162.5 2.5 3.1e-47 160.6 0.4 2.4 2 0 0 2 2 2 1 3'-5' exonuclease PMC2NT PF08066.12 KOG99067.1 - 1.1e-21 77.3 7.5 3.8e-21 75.6 3.7 2.8 2 0 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.23 KOG99067.1 - 3.9e-11 42.8 0.0 8.1e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 HRDC domain Exonuc_VII_L PF02601.15 KOG99067.1 - 0.031 13.9 3.5 0.43 10.1 0.1 2.6 3 1 0 3 3 3 0 Exonuclease VII, large subunit DUF5085 PF16895.5 KOG99067.1 - 0.055 13.8 0.2 0.12 12.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5085) Alg6_Alg8 PF03155.15 KOG99068.1 - 1.5e-143 479.3 30.5 1.8e-143 479.0 30.5 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Peptidase_S8 PF00082.22 KOG99069.1 - 1.8e-30 106.3 2.8 4.5e-30 104.9 2.8 1.6 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 KOG99069.1 - 3e-09 37.4 0.0 7.5e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 Fcf1 PF04900.12 KOG99070.1 - 4.4e-35 120.0 0.4 4.4e-35 120.0 0.4 1.6 2 0 0 2 2 2 1 Fcf1 CDC45 PF02724.14 KOG99070.1 - 0.058 11.7 6.0 0.073 11.4 6.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_ligase_A_M PF01068.21 KOG99071.1 - 1.2e-53 181.8 0.0 3.8e-53 180.2 0.0 1.8 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 KOG99071.1 - 1.5e-23 84.0 0.0 4.5e-23 82.4 0.0 1.9 1 0 0 1 1 1 1 DNA ligase N terminus BRCT_2 PF16589.5 KOG99071.1 - 1.8e-18 66.8 0.0 1.5e-09 38.2 0.0 2.7 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 KOG99071.1 - 2.3e-10 40.7 0.4 8.7e-05 22.8 0.0 3.0 2 1 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RNA_ligase PF09414.10 KOG99071.1 - 2.5e-10 40.9 0.0 5.8e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_C PF04679.15 KOG99071.1 - 0.001 19.6 0.0 0.0028 18.2 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region Fve PF09259.11 KOG99071.1 - 0.0031 17.6 0.0 0.51 10.5 0.0 2.6 2 0 0 2 2 2 1 Fungal immunomodulatory protein Fve mRNA_cap_enzyme PF01331.19 KOG99071.1 - 0.0051 16.7 0.7 1.5 8.6 0.0 2.6 2 0 0 2 2 2 2 mRNA capping enzyme, catalytic domain Ribo_biogen_C PF04034.13 KOG99072.1 - 7e-51 171.2 0.0 9.7e-51 170.8 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 KOG99072.1 - 5.2e-16 58.2 0.3 9e-16 57.4 0.3 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SDA1 PF05285.12 KOG99072.1 - 8.6 5.7 20.0 17 4.7 20.0 1.4 1 0 0 1 1 1 0 SDA1 DUF4746 PF15928.5 KOG99072.1 - 9.6 5.5 8.9 15 4.9 8.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SGTA_dimer PF16546.5 KOG99073.1 - 1e-19 70.1 1.6 2.7e-19 68.7 1.6 1.8 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 KOG99073.1 - 8.3e-19 66.5 6.1 5.7e-07 29.1 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOG99073.1 - 2.6e-16 58.4 7.7 1.8e-05 24.5 0.2 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOG99073.1 - 2.7e-14 52.6 8.9 1.6e-05 24.5 0.0 3.3 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 KOG99073.1 - 2.6e-08 33.4 9.6 0.00089 19.3 0.5 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOG99073.1 - 3.2e-07 30.5 3.7 0.011 16.0 0.0 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOG99073.1 - 5e-07 29.6 0.4 0.0032 17.8 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOG99073.1 - 6.8e-07 29.0 2.7 0.072 13.0 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOG99073.1 - 1.3e-06 28.9 4.3 0.00092 19.8 0.2 2.9 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOG99073.1 - 1.7e-06 28.4 0.4 0.058 14.2 0.0 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOG99073.1 - 3.4e-05 23.6 1.7 2.3 8.4 0.0 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOG99073.1 - 0.00019 21.9 7.8 0.3 11.6 0.1 3.6 2 1 1 4 4 3 2 Tetratricopeptide repeat BTAD PF03704.17 KOG99073.1 - 0.00082 19.8 0.1 0.003 18.0 0.1 1.9 1 1 0 1 1 1 1 Bacterial transcriptional activator domain TPR_6 PF13174.6 KOG99073.1 - 0.00092 19.7 1.3 0.078 13.6 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOG99073.1 - 0.0019 18.3 0.0 0.03 14.5 0.0 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat STI1 PF17830.1 KOG99073.1 - 0.0074 16.2 12.2 0.25 11.3 12.1 2.5 1 1 1 2 2 2 2 STI1 domain Fis1_TPR_C PF14853.6 KOG99073.1 - 0.013 15.6 2.6 2.4 8.3 0.1 3.6 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat GerD PF17898.1 KOG99073.1 - 0.024 14.6 0.5 0.093 12.7 0.5 1.9 1 1 0 1 1 1 0 Spore germination GerD central core domain DUF3856 PF12968.7 KOG99073.1 - 0.046 13.8 1.6 0.24 11.5 1.1 2.5 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) MIT PF04212.18 KOG99073.1 - 0.12 12.5 10.6 0.39 10.8 0.1 3.9 2 2 1 3 3 3 0 MIT (microtubule interacting and transport) domain WSC PF01822.19 KOG99074.1 - 1.1e-11 44.8 13.0 1.1e-11 44.8 13.0 3.0 2 1 0 2 2 1 1 WSC domain TMEM154 PF15102.6 KOG99074.1 - 0.0013 18.6 0.1 0.0013 18.6 0.1 2.7 1 1 1 2 2 1 1 TMEM154 protein family LAP1C PF05609.12 KOG99074.1 - 0.0051 16.0 7.7 0.0071 15.5 7.7 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) Gly-zipper_Omp PF13488.6 KOG99074.1 - 0.006 16.6 9.0 0.012 15.6 9.0 1.4 1 0 0 1 1 1 1 Glycine zipper DUF2207 PF09972.9 KOG99074.1 - 0.0068 15.2 0.0 0.011 14.5 0.0 1.3 1 1 0 1 1 1 1 Predicted membrane protein (DUF2207) Utp14 PF04615.13 KOG99074.1 - 0.03 12.9 3.3 0.036 12.7 3.3 1.2 1 0 0 1 1 1 0 Utp14 protein DUF4514 PF14986.6 KOG99074.1 - 0.034 14.1 0.3 0.062 13.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4514) Yip1 PF04893.17 KOG99074.1 - 0.06 13.1 0.2 0.11 12.3 0.2 1.4 1 0 0 1 1 1 0 Yip1 domain Gly-zipper_YMGG PF13441.6 KOG99074.1 - 0.11 12.3 8.3 0.2 11.4 8.3 1.3 1 0 0 1 1 1 0 YMGG-like Gly-zipper Romo1 PF10247.9 KOG99074.1 - 0.16 12.4 2.4 0.41 11.0 2.4 1.7 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 Bacteriocin_IIc PF10439.9 KOG99074.1 - 0.19 11.8 7.5 0.36 11.0 7.5 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide OSTbeta PF15048.6 KOG99074.1 - 0.21 11.7 0.7 0.78 9.9 0.0 2.0 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein Hamartin PF04388.12 KOG99074.1 - 0.35 9.5 15.6 0.4 9.3 15.6 1.3 1 0 0 1 1 1 0 Hamartin protein EphA2_TM PF14575.6 KOG99074.1 - 0.43 11.5 1.7 0.88 10.5 0.0 2.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SLC12 PF03522.15 KOG99074.1 - 0.87 8.5 6.4 0.83 8.6 5.3 1.5 2 0 0 2 2 2 0 Solute carrier family 12 DUF1275 PF06912.11 KOG99074.1 - 1.1 9.1 7.4 0.14 12.0 2.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1275) RIFIN PF02009.16 KOG99074.1 - 4.6 7.0 11.9 14 5.4 11.8 1.8 1 1 0 1 1 1 0 Rifin Toxin_3 PF00537.18 KOG99074.1 - 5 7.4 9.5 0.62 10.3 3.1 2.3 2 0 0 2 2 2 0 Scorpion toxin-like domain Hid1 PF12722.7 KOG99074.1 - 8.2 4.4 12.9 11 4.0 12.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SRP1_TIP1 PF00660.17 KOG99075.1 - 6.1e-34 116.1 0.2 6.1e-34 116.1 0.2 2.1 2 0 0 2 2 2 1 Seripauperin and TIP1 family Utp14 PF04615.13 KOG99075.1 - 2.2 6.8 18.9 2.8 6.4 18.9 1.3 1 0 0 1 1 1 0 Utp14 protein SRP1_TIP1 PF00660.17 KOG99076.1 - 1.3e-36 124.6 0.2 3.3e-36 123.3 0.2 1.7 1 0 0 1 1 1 1 Seripauperin and TIP1 family PIR PF00399.19 KOG99076.1 - 3.5e-08 32.8 6.8 3.6e-07 29.6 6.8 3.0 1 0 0 1 1 1 1 Yeast PIR protein repeat Spc42p PF11544.8 KOG99076.1 - 0.052 13.6 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Spindle pole body component Spc42p DDHD PF02862.17 KOG99076.1 - 0.29 11.3 7.4 0.42 10.7 7.4 1.4 1 0 0 1 1 1 0 DDHD domain DUF572 PF04502.13 KOG99076.1 - 2.7 7.6 7.5 2.9 7.4 7.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Tmemb_cc2 PF10267.9 KOG99076.1 - 3.2 6.8 11.8 5.2 6.1 11.8 1.4 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Hid1 PF12722.7 KOG99076.1 - 5.8 4.9 11.7 7.1 4.6 11.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ABC2_membrane PF01061.24 KOG99077.1 - 1e-64 217.8 63.3 4.1e-35 121.1 28.4 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 KOG99077.1 - 1.2e-29 103.6 0.0 8e-15 55.6 0.1 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 KOG99077.1 - 8.2e-27 93.0 15.3 1.7e-23 82.3 0.0 3.7 3 0 0 3 3 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 KOG99077.1 - 6e-09 35.5 50.8 3.8e-05 23.0 15.7 3.1 2 1 0 2 2 2 2 ABC-2 family transporter protein RsgA_GTPase PF03193.16 KOG99077.1 - 3.3e-05 23.9 0.1 7.1e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 KOG99077.1 - 8.3e-05 22.5 0.8 0.069 12.9 0.1 2.9 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system M11L PF11099.8 KOG99077.1 - 0.0044 17.3 0.5 0.011 16.0 0.5 1.7 1 0 0 1 1 1 1 Apoptosis regulator M11L like AAA_23 PF13476.6 KOG99077.1 - 0.0044 17.5 0.1 0.013 16.0 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOG99077.1 - 0.0064 16.9 0.1 0.015 15.7 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 KOG99077.1 - 0.01 15.3 0.9 0.45 9.9 0.1 2.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 KOG99077.1 - 0.014 16.0 0.0 0.035 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOG99077.1 - 0.052 13.3 0.4 0.14 11.9 0.4 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 KOG99077.1 - 0.065 13.5 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 KOG99077.1 - 0.1 12.7 0.2 0.69 10.0 0.1 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase SPC25 PF06703.11 KOG99077.1 - 0.11 12.3 0.1 0.11 12.3 0.1 2.8 3 0 0 3 3 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) AAA_25 PF13481.6 KOG99077.1 - 0.23 11.0 0.1 0.54 9.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain B56 PF01603.20 KOG99079.1 - 2.5e-174 580.1 10.2 4.4e-174 579.3 10.2 1.4 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) EMP24_GP25L PF01105.24 KOG99080.1 - 4e-36 124.7 0.1 5e-36 124.3 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Pet127 PF08634.10 KOG99081.1 - 3.9e-103 344.6 8.3 1.1e-102 343.1 8.3 1.8 1 1 0 1 1 1 1 Mitochondrial protein Pet127 TPK_catalytic PF04263.16 KOG99081.1 - 0.14 12.3 0.2 5.8 7.0 0.0 2.6 2 0 0 2 2 2 0 Thiamin pyrophosphokinase, catalytic domain Fib_alpha PF08702.10 KOG99081.1 - 10 6.3 10.0 0.67 10.1 0.4 3.3 4 0 0 4 4 4 0 Fibrinogen alpha/beta chain family Arrestin_C PF02752.22 KOG99082.1 - 2.8e-24 86.1 5.1 8.7e-24 84.5 0.0 3.5 3 1 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 KOG99082.1 - 2.4e-11 43.9 0.0 1.8e-09 37.8 0.0 2.7 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 KOG99082.1 - 0.00013 21.8 0.0 0.00033 20.4 0.0 1.7 1 0 0 1 1 1 1 Arrestin_N terminal like RRM_1 PF00076.22 KOG99083.1 - 1.9e-40 136.5 9.1 5.1e-16 58.3 0.3 4.3 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOG99083.1 - 9.9e-05 21.9 0.3 0.13 11.9 0.1 3.3 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PCI PF01399.27 KOG99083.1 - 0.0045 17.5 0.0 0.32 11.5 0.0 3.2 3 1 0 3 3 3 1 PCI domain Nup35_RRM_2 PF14605.6 KOG99083.1 - 0.018 15.0 0.0 0.79 9.8 0.0 2.6 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 KOG99083.1 - 0.019 15.1 0.3 2.7 8.1 0.0 3.9 3 1 0 3 3 3 0 Limkain b1 RRM_7 PF16367.5 KOG99083.1 - 0.033 14.3 0.5 2.9 8.1 0.0 3.5 3 1 0 3 3 3 0 RNA recognition motif RRM_occluded PF16842.5 KOG99083.1 - 0.047 13.6 0.0 0.29 11.0 0.0 2.3 3 0 0 3 3 3 0 Occluded RNA-recognition motif RL PF17797.1 KOG99083.1 - 0.069 13.1 0.0 0.24 11.4 0.0 1.9 1 0 0 1 1 1 0 RL domain Ysc84 PF04366.12 KOG99084.1 - 8.4e-41 138.7 0.1 8.4e-41 138.7 0.1 1.6 2 0 0 2 2 2 1 Las17-binding protein actin regulator SH3_1 PF00018.28 KOG99084.1 - 5.9e-18 64.2 0.1 1.3e-17 63.1 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KOG99084.1 - 5.6e-13 48.4 0.0 1.1e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KOG99084.1 - 7.3e-12 45.0 0.0 1.4e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.8 KOG99084.1 - 0.13 12.0 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) DUF1776 PF08643.10 KOG99085.1 - 3.3e-62 210.5 0.1 5.4e-62 209.8 0.1 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Lyase_1 PF00206.20 KOG99086.1 - 1.1e-96 323.9 0.0 1.5e-96 323.5 0.0 1.2 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 KOG99086.1 - 2e-22 79.7 0.0 4.6e-22 78.6 0.0 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal BBE PF08031.12 KOG99086.1 - 0.19 11.8 0.5 6.2 7.0 0.0 3.0 3 0 0 3 3 3 0 Berberine and berberine like tRNA-synt_2 PF00152.20 KOG99087.1 - 9.7e-89 297.5 0.0 1.5e-88 296.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOG99087.1 - 3.5e-13 49.3 0.1 7.8e-13 48.2 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Ins134_P3_kin PF05770.11 KOG99087.1 - 0.0053 16.3 0.0 0.0097 15.4 0.0 1.4 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain ProRS-C_1 PF09180.11 KOG99088.1 - 3.3e-26 91.3 0.8 8e-26 90.1 0.8 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 KOG99088.1 - 2.9e-19 69.0 0.2 7e-19 67.8 0.2 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KOG99088.1 - 5e-15 55.9 0.0 1e-14 54.9 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) DUF2482 PF10655.9 KOG99088.1 - 0.17 12.4 1.1 0.77 10.3 0.3 2.1 2 0 0 2 2 2 0 Hypothetical protein of unknown function (DUF2482) Myosin_head PF00063.21 KOG99089.1 - 7.1e-280 930.0 13.8 7.1e-280 930.0 13.8 4.2 4 2 2 6 6 6 1 Myosin head (motor domain) Myosin_N PF02736.19 KOG99089.1 - 0.00019 21.2 0.6 0.0013 18.5 0.1 2.4 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain HMMR_N PF15905.5 KOG99089.1 - 0.0029 17.1 18.9 0.0029 17.1 18.9 8.7 3 2 6 10 10 10 2 Hyaluronan mediated motility receptor N-terminal FlgN PF05130.12 KOG99089.1 - 0.0055 17.2 13.4 0.0055 17.2 13.4 9.9 4 2 4 9 9 9 1 FlgN protein TsaE PF02367.17 KOG99089.1 - 0.034 14.2 0.3 0.16 12.0 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 KOG99089.1 - 0.25 11.7 0.0 0.25 11.7 0.0 3.8 4 1 0 4 4 4 0 AAA ATPase domain AAA_22 PF13401.6 KOG99089.1 - 0.42 10.9 0.0 0.42 10.9 0.0 4.9 4 2 0 4 4 4 0 AAA domain AAA_19 PF13245.6 KOG99089.1 - 1.4 9.3 0.0 1.4 9.3 0.0 3.4 3 0 0 3 3 3 0 AAA domain Tox-REase-9 PF15650.6 KOG99089.1 - 3.6 7.9 6.2 1 9.7 0.6 3.1 3 0 0 3 3 3 0 Restriction endonuclease fold toxin 9 Peptidase_M16_C PF05193.21 KOG99090.1 - 4.2e-49 167.1 0.1 1.9e-48 164.9 0.0 2.1 3 0 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOG99090.1 - 4.8e-46 156.4 0.0 1.7e-43 148.1 0.0 2.2 2 0 0 2 2 2 2 Insulinase (Peptidase family M16) DUF3945 PF13101.6 KOG99090.1 - 0.13 12.0 0.1 0.33 10.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3945) GHMP_kinases_N PF00288.26 KOG99091.1 - 2.3e-09 37.4 0.0 4.4e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KOG99091.1 - 0.00026 21.3 0.0 0.00067 20.0 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal ATP-synt_C PF00137.21 KOG99092.1 - 3.7e-23 81.6 42.0 5.5e-17 61.9 12.6 2.7 3 0 0 3 3 3 2 ATP synthase subunit C RPN1_RPN2_N PF17781.1 KOG99093.1 - 1.6e-114 382.5 1.0 2.8e-114 381.7 0.7 1.6 2 0 0 2 2 2 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 KOG99093.1 - 9.1e-29 99.3 0.1 1.7e-28 98.4 0.1 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 KOG99093.1 - 1.2e-24 85.4 16.6 2e-07 31.1 0.1 7.8 8 0 0 8 8 8 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 KOG99093.1 - 2.4e-05 24.7 0.8 0.72 10.3 0.0 4.7 4 1 1 5 5 5 2 HEAT repeats DUF572 PF04502.13 KOG99093.1 - 1.5 8.4 22.4 0.17 11.5 7.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) RP-C_C PF11800.8 KOG99093.1 - 3.3 7.7 6.8 8.4 6.4 0.6 3.0 3 0 0 3 3 3 0 Replication protein C C-terminal region DPPIV_N PF00930.21 KOG99094.1 - 2.5e-103 345.5 5.6 3.4e-103 345.1 5.6 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 KOG99094.1 - 1.5e-52 178.2 1.4 2.8e-52 177.3 1.4 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 KOG99094.1 - 0.00025 21.7 0.0 0.025 15.2 0.0 2.3 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 KOG99094.1 - 0.07 12.9 0.1 6.7 6.4 0.1 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase PhzC-PhzF PF02567.16 KOG99095.1 - 1.8e-77 260.6 0.0 2e-77 260.4 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.11 KOG99095.1 - 0.12 11.4 0.0 2.2 7.3 0.0 2.1 2 0 0 2 2 2 0 Proline racemase Pkinase PF00069.25 KOG99096.1 - 1.1e-64 218.4 0.7 2.2e-64 217.4 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99096.1 - 1.3e-31 109.9 0.0 2.7e-31 108.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOG99096.1 - 0.0019 17.2 2.4 0.0042 16.1 0.0 2.2 2 1 0 2 2 2 1 Haspin like kinase domain Spt20 PF12090.8 KOG99096.1 - 0.0022 17.7 15.2 0.0041 16.8 15.2 1.4 1 0 0 1 1 1 1 Spt20 family APH PF01636.23 KOG99096.1 - 0.089 12.7 1.4 0.17 11.8 0.1 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family WD40 PF00400.32 KOG99096.1 - 0.12 13.3 0.0 0.74 10.8 0.0 2.4 2 0 0 2 2 2 0 WD domain, G-beta repeat SUIM_assoc PF16619.5 KOG99096.1 - 0.18 11.9 12.9 0.36 10.9 12.9 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PIF1 PF05970.14 KOG99097.1 - 2.6e-52 178.2 4.8 1.1e-45 156.4 1.8 2.2 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 KOG99097.1 - 1e-22 80.8 0.0 1.7e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOG99097.1 - 1.9e-10 41.3 0.1 4.7e-10 40.0 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KOG99097.1 - 4.7e-06 26.2 0.3 1.1e-05 25.1 0.3 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 KOG99097.1 - 3.9e-05 24.0 0.5 0.0002 21.7 0.3 2.3 2 1 0 2 2 1 1 AAA domain Herpes_Helicase PF02689.14 KOG99097.1 - 0.00019 19.5 0.2 0.011 13.7 0.0 2.2 2 0 0 2 2 2 1 Helicase AAA PF00004.29 KOG99097.1 - 0.00036 21.0 0.1 0.00092 19.6 0.1 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 KOG99097.1 - 0.00072 18.7 0.2 0.0013 17.9 0.2 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein SH3_13 PF18335.1 KOG99097.1 - 0.0032 17.3 0.0 0.0082 16.0 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent RecD-like DNA helicase SH3 domain Helicase_RecD PF05127.14 KOG99097.1 - 0.0048 16.8 0.2 0.015 15.2 0.2 1.8 1 1 0 1 1 1 1 Helicase Viral_helicase1 PF01443.18 KOG99097.1 - 0.0083 15.9 0.1 0.39 10.4 0.0 2.9 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 KOG99097.1 - 0.0091 15.5 0.1 0.023 14.1 0.1 1.7 1 0 0 1 1 1 1 PhoH-like protein DUF2075 PF09848.9 KOG99097.1 - 0.011 14.9 0.2 0.029 13.6 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 KOG99097.1 - 0.029 14.4 0.3 0.12 12.3 0.3 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KOG99097.1 - 0.03 13.7 0.2 0.073 12.4 0.1 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 KOG99097.1 - 0.051 14.1 0.8 0.15 12.5 0.4 1.9 1 1 0 1 1 1 0 ABC transporter FtsK_SpoIIIE PF01580.18 KOG99097.1 - 0.055 12.8 0.2 0.13 11.6 0.1 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family UvrD_C_2 PF13538.6 KOG99097.1 - 0.097 12.5 0.7 0.58 10.0 0.7 2.2 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain RNA_helicase PF00910.22 KOG99097.1 - 0.11 12.9 0.8 1.3 9.5 0.3 2.8 2 1 0 2 2 2 0 RNA helicase Parvo_NS1 PF01057.17 KOG99097.1 - 0.11 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 MatE PF01554.18 KOG99098.1 - 1.1e-69 233.2 26.6 1e-41 142.3 9.5 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 KOG99098.1 - 0.0002 21.4 26.3 0.00041 20.4 7.4 3.6 3 1 0 3 3 3 2 Polysaccharide biosynthesis C-terminal domain AA_kinase PF00696.28 KOG99099.1 - 1e-35 123.5 0.1 1.6e-35 122.8 0.1 1.3 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 KOG99099.1 - 5.7e-16 58.2 0.0 1.1e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 PUA domain PIH1 PF08190.12 KOG99100.1 - 1e-19 70.6 0.1 2e-19 69.7 0.1 1.5 1 0 0 1 1 1 1 PIH1 N-terminal domain Pih1_fungal_CS PF18482.1 KOG99100.1 - 4.6e-17 62.3 0.2 1e-16 61.2 0.0 1.7 2 0 0 2 2 2 1 Fungal Pih1 CS domain Sec23_trunk PF04811.15 KOG99101.1 - 6.9e-18 65.1 0.1 1.5e-17 64.0 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 KOG99101.1 - 0.036 13.9 0.0 0.097 12.5 0.0 1.8 1 0 0 1 1 1 0 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 KOG99101.1 - 0.094 12.8 5.0 0.04 14.0 1.9 2.1 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Brr6_like_C_C PF10104.9 KOG99102.1 - 8.6e-45 151.8 4.5 1.3e-44 151.2 4.5 1.3 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain RAI16-like PF10257.9 KOG99102.1 - 0.061 12.2 0.1 0.12 11.3 0.1 1.4 1 0 0 1 1 1 0 Retinoic acid induced 16-like protein Aldedh PF00171.22 KOG99103.1 - 9.4e-101 337.6 0.0 1.1e-100 337.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family RRF PF01765.19 KOG99104.1 - 2e-36 125.4 2.3 2e-36 125.4 2.3 1.5 1 1 1 2 2 2 1 Ribosome recycling factor DUF2884 PF11101.8 KOG99104.1 - 0.0011 18.6 2.5 0.01 15.4 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2884) Cor1 PF04803.12 KOG99104.1 - 1.3 9.2 12.7 0.32 11.2 2.6 2.9 2 1 0 2 2 2 0 Cor1/Xlr/Xmr conserved region Pox_polyA_pol_N PF12630.7 KOG99104.1 - 4.8 7.6 8.4 0.55 10.6 1.7 2.6 2 1 1 3 3 3 0 Poxvirus poly(A) polymerase N-terminal domain Aldedh PF00171.22 KOG99105.1 - 7.7e-129 430.2 0.0 9.2e-129 429.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family zf-HIT PF04438.16 KOG99106.1 - 6.7e-11 41.9 7.7 1.1e-10 41.1 7.7 1.4 1 0 0 1 1 1 1 HIT zinc finger Sec39 PF08314.11 KOG99106.1 - 0.0084 14.6 0.1 0.012 14.2 0.1 1.2 1 0 0 1 1 1 1 Secretory pathway protein Sec39 zf-MYND PF01753.18 KOG99106.1 - 4.3 7.5 11.1 12 6.1 11.1 1.8 1 0 0 1 1 1 0 MYND finger Med20 PF08612.11 KOG99107.1 - 8.3e-28 97.3 0.0 9.2e-28 97.1 0.0 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex FAD_binding_1 PF00667.20 KOG99108.1 - 8.5e-74 247.9 0.0 1.2e-73 247.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 KOG99108.1 - 1.2e-30 106.6 1.1 2.1e-30 105.8 1.1 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 KOG99108.1 - 1.9e-22 79.9 0.0 4e-22 78.9 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 KOG99108.1 - 0.021 15.0 0.0 0.047 13.9 0.0 1.6 1 0 0 1 1 1 0 Flavodoxin domain HAD_2 PF13419.6 KOG99109.1 - 4.4e-14 53.0 0.0 7.1e-14 52.3 0.0 1.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOG99109.1 - 1.4e-07 32.0 0.1 1.8e-05 25.1 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Inositol_P PF00459.25 KOG99111.1 - 3.9e-72 243.0 0.0 4.4e-72 242.9 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Peptidase_M1 PF01433.20 KOG99112.1 - 1.3e-88 296.2 6.5 1.8e-88 295.8 4.8 2.0 2 0 0 2 2 2 1 Peptidase family M1 domain ERAP1_C PF11838.8 KOG99112.1 - 3e-77 260.3 4.9 2.1e-76 257.5 1.0 2.8 2 1 1 3 3 3 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 KOG99112.1 - 7.5e-54 182.7 2.5 7.5e-54 182.7 2.5 1.7 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain HA2 PF04408.23 KOG99112.1 - 0.11 12.8 0.0 0.28 11.5 0.0 1.7 1 0 0 1 1 1 0 Helicase associated domain (HA2) MFS_1 PF07690.16 KOG99113.1 - 1.4e-40 139.4 25.7 1.4e-40 139.4 25.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG99113.1 - 5.4e-05 22.2 35.6 0.00035 19.6 35.6 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter FSH1 PF03959.13 KOG99114.1 - 9.7e-64 214.9 0.0 1.1e-63 214.7 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 KOG99114.1 - 0.0015 18.4 0.0 0.77 9.5 0.0 2.3 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase BAAT_C PF08840.11 KOG99114.1 - 0.021 14.7 0.3 0.3 11.0 0.0 2.1 1 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Nramp PF01566.18 KOG99115.1 - 2.4e-93 313.0 14.1 3.8e-93 312.3 14.1 1.3 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein DUF5345 PF17280.2 KOG99115.1 - 0.12 12.4 0.0 0.71 9.9 0.0 2.4 1 0 0 1 1 1 0 Family of unknown function (DUF5345) COX5A PF02284.16 KOG99116.1 - 2.4e-40 136.7 1.2 3.2e-40 136.3 1.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Nterm_IS4 PF13006.7 KOG99116.1 - 0.089 13.0 0.1 0.41 10.9 0.0 1.9 2 0 0 2 2 2 0 Insertion element 4 transposase N-terminal Ribosomal_L1 PF00687.21 KOG99117.1 - 1e-31 110.3 6.5 1e-31 110.3 6.5 2.1 1 1 1 2 2 2 1 Ribosomal protein L1p/L10e family Yeast_MT PF11403.8 KOG99118.1 - 2.9e-21 75.8 34.3 2.9e-21 75.8 34.3 1.5 2 0 0 2 2 2 1 Yeast metallothionein Zn_clus PF00172.18 KOG99119.1 - 6.2e-08 32.6 8.8 1.1e-07 31.8 8.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mucin PF01456.17 KOG99119.1 - 0.22 11.5 4.3 0.44 10.5 4.3 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Pro_isomerase PF00160.21 KOG99120.1 - 5e-47 160.1 0.5 5.9e-47 159.9 0.5 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD FTP PF07504.13 KOG99120.1 - 0.031 14.1 2.3 0.18 11.7 0.3 2.6 3 0 0 3 3 3 0 Fungalysin/Thermolysin Propeptide Motif Med6 PF04934.14 KOG99121.1 - 1.7e-50 170.3 1.0 2.2e-50 169.9 1.0 1.1 1 0 0 1 1 1 1 MED6 mediator sub complex component IGR PF09597.10 KOG99122.1 - 1.8e-23 82.3 0.4 2.9e-23 81.7 0.4 1.3 1 0 0 1 1 1 1 IGR protein motif zf_C2H2_10 PF18414.1 KOG99122.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger Laminin_G_2 PF02210.24 KOG99123.1 - 0.094 13.3 0.1 0.17 12.5 0.0 1.6 1 1 0 1 1 1 0 Laminin G domain RNase_P_p30 PF01876.16 KOG99125.1 - 1e-72 244.1 0.0 1.3e-72 243.8 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit p30 ApbA PF02558.16 KOG99126.1 - 6e-36 123.4 0.0 8.3e-36 122.9 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 KOG99126.1 - 4.5e-24 85.0 0.0 7.6e-24 84.3 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal NAD_Gly3P_dh_N PF01210.23 KOG99126.1 - 0.021 14.8 0.0 0.19 11.7 0.0 2.2 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus BBS2_C PF14782.6 KOG99126.1 - 0.037 12.8 0.5 0.055 12.2 0.5 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal HSP70 PF00012.20 KOG99127.1 - 8.5e-75 252.1 0.8 1.5e-73 248.0 0.3 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 KOG99127.1 - 8e-10 38.0 0.0 1.2e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein Actin PF00022.19 KOG99127.1 - 0.0051 15.5 0.1 0.091 11.4 0.1 2.5 2 1 1 3 3 3 1 Actin DEAD PF00270.29 KOG99128.1 - 5.1e-49 166.4 0.0 8.6e-49 165.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG99128.1 - 3.4e-30 104.6 0.2 3e-29 101.6 0.0 2.7 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG99128.1 - 1.8e-06 28.0 0.9 7.7e-06 26.0 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 KOG99128.1 - 0.0031 17.3 0.0 0.021 14.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOG99128.1 - 0.01 16.2 0.0 0.098 13.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain RBR PF17208.3 KOG99128.1 - 0.23 12.2 2.5 0.55 11.0 2.5 1.6 1 0 0 1 1 1 0 RNA binding Region RP-C_C PF11800.8 KOG99128.1 - 2.7 8.1 6.9 5.3 7.1 6.9 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region ATP11 PF06644.11 KOG99128.1 - 5.3 6.8 10.1 7.9 6.2 10.1 1.2 1 0 0 1 1 1 0 ATP11 protein Brix PF04427.18 KOG99129.1 - 9.4e-50 169.4 3.4 9.4e-50 169.4 3.4 1.5 2 0 0 2 2 2 1 Brix domain DUF2514 PF10721.9 KOG99129.1 - 9.5 6.2 15.0 0.1 12.6 5.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) MaoC_dehydrat_N PF13452.6 KOG99130.1 - 0.018 15.2 0.0 0.19 11.8 0.0 2.4 2 1 0 2 2 2 0 N-terminal half of MaoC dehydratase MaoC_dehydratas PF01575.19 KOG99130.1 - 0.042 13.4 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 MaoC like domain DS PF01916.17 KOG99131.1 - 1.4e-129 431.4 0.1 1.7e-129 431.2 0.1 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase ECR1_N PF14382.6 KOG99132.1 - 7.4e-17 60.9 0.9 1e-16 60.4 0.2 1.7 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 KOG99132.1 - 2e-10 40.9 0.1 3.9e-10 39.9 0.1 1.5 1 0 0 1 1 1 1 KH domain Met_10 PF02475.16 KOG99133.1 - 1.2e-78 263.4 0.0 1.9e-78 262.8 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 KOG99133.1 - 0.00062 19.1 0.1 0.0013 18.0 0.0 1.5 2 0 0 2 2 2 1 N2,N2-dimethylguanosine tRNA methyltransferase MethyltransfD12 PF02086.15 KOG99133.1 - 0.0033 17.1 0.0 0.0055 16.4 0.0 1.3 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase PrmA PF06325.13 KOG99133.1 - 0.033 13.6 0.0 0.054 12.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF4438 PF14505.6 KOG99133.1 - 0.13 11.2 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4438) Cyclin_N PF00134.23 KOG99134.1 - 2.2e-09 37.1 0.0 3.1e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 KOG99134.1 - 0.047 14.1 0.0 0.064 13.6 0.0 1.2 1 0 0 1 1 1 0 Cyclin SQHop_cyclase_C PF13243.6 KOG99135.1 - 1.3e-42 146.0 0.0 6.6e-42 143.7 0.0 1.9 2 0 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 KOG99135.1 - 1.4e-33 116.3 0.0 1.1e-29 103.5 0.0 3.2 2 1 1 3 3 3 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 KOG99135.1 - 3.6e-28 97.0 0.4 1.3e-08 34.4 0.1 4.0 3 0 0 3 3 3 3 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 KOG99135.1 - 0.0021 17.4 0.0 0.52 9.6 0.0 2.5 1 1 1 2 2 2 2 Pectic acid lyase TED_complement PF07678.14 KOG99135.1 - 0.023 13.7 0.1 0.099 11.6 0.0 1.9 2 1 0 2 2 2 0 A-macroglobulin TED domain Nop10p PF04135.12 KOG99136.1 - 7.8e-22 77.1 0.5 8.7e-22 76.9 0.5 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family Oxysterol_BP PF01237.18 KOG99137.1 - 6.8e-101 337.8 5.9 6.8e-101 337.8 5.9 2.5 2 1 0 2 2 2 1 Oxysterol-binding protein PH_8 PF15409.6 KOG99137.1 - 3.3e-33 113.8 4.3 2.2e-32 111.2 0.5 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 KOG99137.1 - 1.4e-07 32.0 0.6 1.4e-07 32.0 0.6 2.7 2 1 0 2 2 2 1 PH domain CAF20 PF17052.5 KOG99137.1 - 0.019 15.1 2.3 0.074 13.2 2.3 2.0 1 0 0 1 1 1 0 Cap associated factor PH_11 PF15413.6 KOG99137.1 - 0.1 13.0 10.3 0.2 12.1 3.9 3.6 2 1 0 2 2 2 0 Pleckstrin homology domain CN_hydrolase PF00795.22 KOG99138.1 - 3e-44 151.3 0.0 4e-44 150.9 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 KOG99138.1 - 1.2e-22 80.3 0.0 3.1e-22 78.9 0.0 1.6 1 1 0 1 1 1 1 NAD synthase Abhydrolase_1 PF00561.20 KOG99139.1 - 6.6e-21 75.1 0.1 1.2e-20 74.2 0.0 1.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOG99139.1 - 2.7e-18 67.4 0.0 4e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOG99139.1 - 5.5e-08 32.4 0.0 8.2e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 VirJ PF06057.11 KOG99139.1 - 0.00093 19.1 0.0 0.0057 16.6 0.0 2.0 2 0 0 2 2 2 1 Bacterial virulence protein (VirJ) Thioesterase PF00975.20 KOG99139.1 - 0.0023 18.1 0.1 0.017 15.2 0.1 2.3 1 1 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 KOG99139.1 - 0.011 15.5 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein Lipase_3 PF01764.25 KOG99139.1 - 0.013 15.4 0.0 0.032 14.1 0.0 1.7 2 0 0 2 2 2 0 Lipase (class 3) DUF2974 PF11187.8 KOG99139.1 - 0.013 15.1 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) AAA_35 PF14516.6 KOG99139.1 - 0.044 12.6 0.0 0.081 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain PAF-AH_p_II PF03403.13 KOG99139.1 - 0.049 12.1 0.0 3.5 6.0 0.0 2.2 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_2 PF02230.16 KOG99139.1 - 0.059 13.2 0.1 11 5.8 0.0 2.6 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DUF676 PF05057.14 KOG99139.1 - 0.071 12.6 0.0 0.19 11.2 0.0 1.7 2 0 0 2 2 2 0 Putative serine esterase (DUF676) LIDHydrolase PF10230.9 KOG99139.1 - 0.081 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase SpoIIE PF07228.12 KOG99141.1 - 4.5e-40 137.6 0.0 1.1e-39 136.4 0.0 1.6 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 KOG99141.1 - 2.4e-07 30.6 0.3 0.00033 20.4 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 KOG99141.1 - 0.00053 19.7 0.0 0.0011 18.7 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C MIF4G PF02854.19 KOG99142.1 - 1e-53 182.1 31.3 1.6e-42 145.6 5.3 4.0 3 1 0 3 3 3 2 MIF4G domain Upf2 PF04050.14 KOG99142.1 - 9.8e-27 94.3 16.5 9.8e-27 94.3 16.5 2.6 3 0 0 3 3 3 1 Up-frameshift suppressor 2 PPP4R2 PF09184.11 KOG99142.1 - 0.0018 17.9 28.9 0.0018 17.9 28.9 2.7 2 0 0 2 2 2 1 PPP4R2 HD_2 PF12917.7 KOG99142.1 - 0.03 14.1 8.1 1.4 8.6 0.1 2.7 2 0 0 2 2 2 0 HD containing hydrolase-like enzyme Nop14 PF04147.12 KOG99142.1 - 1.3 7.1 44.1 0.37 9.0 40.5 2.0 2 0 0 2 2 2 0 Nop14-like family ABA_GPCR PF12430.8 KOG99143.1 - 6.2e-61 205.3 3.2 6.2e-61 205.3 3.2 2.3 2 1 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 KOG99143.1 - 2.8e-17 62.5 0.1 8.2e-17 61.1 0.1 1.9 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal Sec20 PF03908.13 KOG99143.1 - 8 6.5 7.4 6.7 6.7 0.2 3.2 3 0 0 3 3 3 0 Sec20 Pkinase PF00069.25 KOG99144.1 - 5.5e-45 153.8 0.0 1.4e-31 109.8 0.0 2.2 1 1 0 2 2 2 2 Protein kinase domain Ribonuc_2-5A PF06479.12 KOG99144.1 - 3.4e-41 140.4 0.8 9.5e-41 138.9 0.0 2.2 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 KOG99144.1 - 3.3e-24 85.6 0.0 6.6e-23 81.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.21 KOG99144.1 - 0.0001 22.0 0.1 0.33 11.0 0.0 3.6 3 0 0 3 3 3 1 PQQ enzyme repeat Kdo PF06293.14 KOG99144.1 - 0.00021 20.7 0.0 0.00038 19.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOG99144.1 - 0.041 12.6 0.1 0.066 12.0 0.1 1.4 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 KOG99144.1 - 0.054 13.4 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sigma_1s PF02454.16 KOG99144.1 - 0.26 11.3 1.4 0.5 10.4 0.0 2.3 2 0 0 2 2 2 0 Sigma 1s protein Swi5 PF07061.11 KOG99145.1 - 1.4e-22 79.6 3.7 1.7e-22 79.3 3.7 1.1 1 0 0 1 1 1 1 Swi5 DUF2951 PF11166.8 KOG99145.1 - 0.0029 17.8 1.6 0.0034 17.6 1.4 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2951) Holin_BhlA PF10960.8 KOG99145.1 - 0.0094 15.9 1.7 0.018 15.0 1.6 1.5 1 1 0 1 1 1 1 BhlA holin family DUF4349 PF14257.6 KOG99145.1 - 0.098 12.1 1.2 0.13 11.7 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) S1-P1_nuclease PF02265.16 KOG99145.1 - 0.13 12.0 0.2 0.16 11.8 0.2 1.1 1 0 0 1 1 1 0 S1/P1 Nuclease BST2 PF16716.5 KOG99145.1 - 0.14 12.8 3.6 0.15 12.6 3.3 1.3 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 FapA PF03961.13 KOG99145.1 - 0.48 9.0 6.3 0.48 9.0 6.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A VASt PF16016.5 KOG99146.1 - 5.6e-73 244.4 0.3 4.4e-36 124.6 0.0 2.6 2 0 0 2 2 2 2 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 KOG99146.1 - 1.1e-27 96.2 0.0 2.8e-27 94.9 0.0 1.8 1 0 0 1 1 1 1 GRAM domain Peptidase_S49_N PF08496.10 KOG99146.1 - 1 9.4 4.3 9.1 6.3 0.8 3.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Sas10_Utp3 PF04000.15 KOG99147.1 - 2.9e-08 34.2 3.2 2.9e-08 34.2 3.2 1.9 2 1 0 2 2 2 1 Sas10/Utp3/C1D family Snapin_Pallidin PF14712.6 KOG99147.1 - 1 9.8 6.8 11 6.6 2.2 2.8 1 1 1 2 2 2 0 Snapin/Pallidin Pkinase PF00069.25 KOG99148.1 - 3.1e-42 144.8 2.2 9.4e-39 133.3 0.8 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99148.1 - 2.8e-20 72.7 0.2 9.9e-20 70.9 0.1 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG99148.1 - 3.4e-05 23.3 0.0 5.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOG99148.1 - 0.064 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SAM35 PF10806.8 KOG99149.1 - 1.1e-44 151.7 0.0 3.7e-44 150.0 0.0 1.9 2 1 1 3 3 3 1 SAM35, subunit of SAM coomplex STE PF02200.16 KOG99150.1 - 7.3e-59 197.0 2.5 1.1e-58 196.3 2.5 1.3 1 0 0 1 1 1 1 STE like transcription factor Ipi1_N PF12333.8 KOG99151.1 - 2.3e-25 89.1 0.1 2.3e-25 89.1 0.1 1.9 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation TPK_catalytic PF04263.16 KOG99151.1 - 0.017 15.2 1.0 0.035 14.2 0.5 1.8 2 0 0 2 2 2 0 Thiamin pyrophosphokinase, catalytic domain HEAT_2 PF13646.6 KOG99151.1 - 0.094 13.1 0.0 5.2 7.5 0.0 3.1 3 1 0 3 3 3 0 HEAT repeats RRM_1 PF00076.22 KOG99152.1 - 1e-41 140.6 0.0 8.5e-17 60.7 0.0 4.2 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOG99152.1 - 2.6e-05 24.3 0.0 0.056 13.6 0.0 3.6 3 0 0 3 3 3 1 RNA recognition motif Nup35_RRM_2 PF14605.6 KOG99152.1 - 0.0061 16.5 0.0 0.018 15.1 0.0 1.9 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KOG99152.1 - 0.15 12.2 0.0 0.42 10.7 0.0 1.7 1 0 0 1 1 1 0 RNA binding motif SBDS PF01172.18 KOG99153.1 - 3.5e-15 55.8 0.2 4e-15 55.7 0.2 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Brix PF04427.18 KOG99154.1 - 1.3e-24 87.4 0.5 2e-24 86.8 0.5 1.3 1 0 0 1 1 1 1 Brix domain Gar1 PF04410.14 KOG99155.1 - 6e-39 133.3 0.0 8e-39 132.9 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region ING PF12998.7 KOG99156.1 - 7e-21 74.7 3.5 7e-21 74.7 3.5 2.0 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 KOG99156.1 - 2.1e-06 27.5 8.1 2.1e-06 27.5 8.1 1.7 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.6 KOG99156.1 - 0.016 15.5 1.8 0.021 15.1 0.5 1.9 2 0 0 2 2 2 0 PHD-like zinc-binding domain tRNA-synt_1d PF00750.19 KOG99157.1 - 7.1e-143 475.8 7.0 8.8e-143 475.4 7.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 KOG99157.1 - 7.8e-26 90.6 0.1 7.8e-25 87.4 0.0 2.3 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 KOG99157.1 - 0.0003 21.3 0.0 0.0008 19.9 0.0 1.8 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain Sugar_tr PF00083.24 KOG99158.1 - 4e-173 576.4 34.3 4.6e-173 576.2 34.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG99158.1 - 1.2e-25 90.3 33.0 3.3e-25 88.7 24.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 KOG99158.1 - 0.2 10.0 6.6 0.038 12.4 2.2 1.8 2 0 0 2 2 2 0 Transmembrane secretion effector DUF4383 PF14325.6 KOG99158.1 - 4.4 7.6 12.7 1.7 8.9 1.3 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4383) Sugar_tr PF00083.24 KOG99159.1 - 1.4e-171 571.3 34.1 1.6e-171 571.1 34.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG99159.1 - 1.8e-30 106.0 30.6 2.3e-29 102.4 22.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG99160.1 - 2e-169 564.2 35.0 2.3e-169 564.0 35.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG99160.1 - 1.6e-35 122.7 39.3 9.6e-33 113.6 24.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4293 PF14126.6 KOG99160.1 - 0.27 11.5 8.8 0.43 10.8 1.7 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) Pal1 PF08316.11 KOG99161.1 - 3.1e-53 180.2 3.0 3.1e-53 180.2 3.0 2.6 3 1 0 3 3 3 1 Pal1 cell morphology protein TMEM51 PF15345.6 KOG99161.1 - 5.4 6.8 13.4 0.85 9.4 8.7 2.0 2 0 0 2 2 2 0 Transmembrane protein 51 Sec23_trunk PF04811.15 KOG99162.1 - 2.8e-66 223.5 0.2 6e-66 222.5 0.1 1.6 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 KOG99162.1 - 5.7e-19 67.9 0.1 1.5e-18 66.5 0.1 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 KOG99162.1 - 6e-14 52.5 0.0 1.3e-13 51.5 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 KOG99162.1 - 1.7e-11 44.0 2.9 3.6e-11 42.9 2.9 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KOG99162.1 - 8.8e-10 38.4 0.1 3.8e-09 36.3 0.0 2.1 2 0 0 2 2 2 1 Gelsolin repeat FAT PF02259.23 KOG99163.1 - 2.5e-70 237.4 9.3 6.8e-70 236.0 9.3 1.8 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 KOG99163.1 - 2.4e-61 207.7 2.2 2.4e-61 207.7 2.2 2.7 3 0 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 KOG99163.1 - 0.00019 21.2 0.0 0.00051 19.8 0.0 1.8 1 0 0 1 1 1 1 FATC domain 2-oxogl_dehyd_N PF16078.5 KOG99163.1 - 0.1 12.2 0.0 0.29 10.8 0.0 1.7 1 0 0 1 1 1 0 2-oxoglutarate dehydrogenase N-terminus TPR_2 PF07719.17 KOG99163.1 - 0.18 12.0 0.3 32 5.0 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat PXA PF02194.15 KOG99163.1 - 0.35 10.8 4.7 3.4 7.6 0.0 3.7 3 0 0 3 3 3 0 PXA domain PGP_phosphatase PF09419.10 KOG99164.1 - 3.4e-72 241.5 0.0 3.9e-72 241.3 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 KOG99164.1 - 2.1e-06 27.7 0.0 3.7e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Pkinase PF00069.25 KOG99166.1 - 6.9e-71 238.7 0.0 1.1e-70 238.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99166.1 - 2.1e-50 171.4 0.0 3.3e-50 170.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOG99166.1 - 4.3e-06 25.8 0.8 5.3e-05 22.2 0.0 2.6 3 0 0 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 KOG99166.1 - 0.00041 19.8 0.1 0.011 15.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KOG99166.1 - 0.52 9.2 4.1 0.4 9.6 0.1 2.7 3 0 0 3 3 3 0 Haspin like kinase domain SBE2 PF17076.5 KOG99167.1 - 0 1297.5 36.2 0 1297.2 36.2 1.0 1 0 0 1 1 1 1 SBE2, cell-wall formation Aldo_ket_red PF00248.21 KOG99168.1 - 6e-41 140.6 0.0 1.1e-40 139.7 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family PX PF00787.24 KOG99169.1 - 6.3e-19 68.0 0.2 8.3e-19 67.6 0.2 1.2 1 0 0 1 1 1 1 PX domain Pyr_redox_2 PF07992.14 KOG99170.1 - 2.7e-49 168.0 0.2 3e-49 167.8 0.2 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOG99170.1 - 4.2e-18 65.7 0.2 5.2e-15 55.8 0.1 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOG99170.1 - 2.3e-14 53.3 0.0 7.8e-13 48.3 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOG99170.1 - 6e-05 22.3 0.7 0.66 9.0 0.2 3.9 3 1 1 4 4 4 2 Glucose inhibited division protein A NAD_binding_7 PF13241.6 KOG99170.1 - 0.00013 22.3 0.1 0.065 13.7 0.0 2.3 2 0 0 2 2 2 2 Putative NAD(P)-binding NAD_binding_8 PF13450.6 KOG99170.1 - 0.00038 20.6 0.1 0.042 14.1 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KOG99170.1 - 0.0014 17.9 0.0 0.0072 15.6 0.0 2.0 2 0 0 2 2 2 1 Thi4 family K_oxygenase PF13434.6 KOG99170.1 - 0.012 14.8 0.0 1.2 8.2 0.0 2.9 2 1 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 KOG99170.1 - 0.029 13.1 0.4 1.2 7.7 0.1 2.8 2 1 1 3 3 3 0 HI0933-like protein FAD_binding_2 PF00890.24 KOG99170.1 - 0.049 12.7 0.9 0.82 8.7 0.3 2.8 3 1 1 4 4 4 0 FAD binding domain FAD_binding_3 PF01494.19 KOG99170.1 - 0.051 12.8 0.1 5.1 6.2 0.1 2.2 2 0 0 2 2 2 0 FAD binding domain Shikimate_DH PF01488.20 KOG99170.1 - 0.15 12.1 0.1 11 6.0 0.0 2.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Septin PF00735.18 KOG99171.1 - 1.3e-119 398.6 0.0 1.9e-119 398.1 0.0 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KOG99171.1 - 3e-07 30.5 0.0 6e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG99171.1 - 1.2e-06 28.5 1.8 2.2e-05 24.4 0.0 2.6 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 KOG99171.1 - 5.3e-05 22.9 0.3 0.014 15.0 0.0 2.6 2 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 KOG99171.1 - 0.0016 18.7 0.2 0.0051 17.1 0.1 2.1 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOG99171.1 - 0.004 17.6 0.2 0.0095 16.3 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain Roc PF08477.13 KOG99171.1 - 0.012 15.8 0.3 0.035 14.3 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 KOG99171.1 - 0.015 15.7 0.0 0.032 14.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Pox_A32 PF04665.12 KOG99171.1 - 0.018 14.5 0.1 0.032 13.7 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AIG1 PF04548.16 KOG99171.1 - 0.018 14.3 0.0 0.048 13.0 0.0 1.7 2 0 0 2 2 2 0 AIG1 family ABC_tran PF00005.27 KOG99171.1 - 0.022 15.3 0.0 0.07 13.6 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 KOG99171.1 - 0.028 14.1 0.2 0.07 12.8 0.2 1.8 1 1 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 KOG99171.1 - 0.033 13.4 0.0 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain NACHT PF05729.12 KOG99171.1 - 0.044 13.7 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Dynamin_N PF00350.23 KOG99171.1 - 0.046 13.8 3.6 18 5.3 0.0 3.3 2 1 1 3 3 3 0 Dynamin family AAA_7 PF12775.7 KOG99171.1 - 0.049 13.1 0.1 0.24 10.9 0.1 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 KOG99171.1 - 0.049 13.3 0.0 0.089 12.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain IIGP PF05049.13 KOG99171.1 - 0.084 11.9 0.0 0.17 10.9 0.0 1.6 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_33 PF13671.6 KOG99171.1 - 0.096 12.8 0.2 0.34 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 KOG99171.1 - 0.14 11.5 0.1 0.98 8.7 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region PGBA_C PF15437.6 KOG99171.1 - 0.55 10.6 4.8 1.6 9.1 4.8 1.9 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA C-terminal DUF3970 PF13113.6 KOG99171.1 - 1.8 8.8 4.3 10 6.4 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) VHS PF00790.19 KOG99172.1 - 2.8e-49 166.6 0.2 1.1e-48 164.7 0.0 2.0 2 0 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.20 KOG99172.1 - 8.2e-25 87.3 0.2 8.2e-25 87.3 0.2 2.3 2 1 0 2 2 2 1 Adaptin C-terminal domain GAT PF03127.14 KOG99172.1 - 3.2e-18 65.8 5.3 1.2e-17 64.0 5.3 2.1 1 0 0 1 1 1 1 GAT domain GGA_N-GAT PF18308.1 KOG99172.1 - 6.7e-06 25.6 3.9 9.1e-06 25.2 0.1 2.7 2 0 0 2 2 2 1 GGA N-GAT domain SOGA PF11365.8 KOG99172.1 - 0.38 11.9 7.3 0.56 11.4 2.4 2.8 1 1 2 3 3 3 0 Protein SOGA LMBR1 PF04791.16 KOG99172.1 - 7.2 5.4 6.9 11 4.8 6.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein EMP24_GP25L PF01105.24 KOG99174.1 - 4.6e-49 166.8 0.4 5.4e-49 166.6 0.4 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Synaptobrevin PF00957.21 KOG99174.1 - 4.2 7.2 6.4 0.16 11.8 0.8 1.5 2 0 0 2 2 2 0 Synaptobrevin ThiF PF00899.21 KOG99175.1 - 5.2e-62 209.4 0.0 1.3e-61 208.0 0.0 1.6 2 0 0 2 2 2 1 ThiF family Rhodanese PF00581.20 KOG99175.1 - 6e-15 55.7 0.1 2.1e-14 53.9 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain Shikimate_DH PF01488.20 KOG99175.1 - 0.0036 17.4 0.0 0.0097 16.0 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DUF4763 PF15960.5 KOG99175.1 - 0.021 14.2 0.9 0.045 13.1 0.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) CDKN3 PF05706.12 KOG99175.1 - 0.048 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) NAD_binding_7 PF13241.6 KOG99175.1 - 0.11 12.9 0.0 0.36 11.3 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding FlaC_arch PF05377.11 KOG99175.1 - 0.17 12.3 0.6 1.6 9.2 0.3 2.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Cys_Met_Meta_PP PF01053.20 KOG99176.1 - 4.2e-63 213.2 0.0 1.3e-62 211.6 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KOG99176.1 - 0.00032 19.8 0.0 0.00047 19.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Peptidase_M18 PF02127.15 KOG99177.1 - 4.8e-189 628.6 0.0 5.5e-189 628.4 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 KOG99177.1 - 4.6e-08 32.4 0.0 2.7e-05 23.3 0.0 2.4 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase SH3_9 PF14604.6 KOG99178.1 - 2e-26 91.6 0.3 2.4e-13 49.7 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 KOG99178.1 - 1.2e-24 85.7 0.3 7.4e-12 44.7 0.0 2.7 2 0 0 2 2 2 2 SH3 domain FCH PF00611.23 KOG99178.1 - 2.4e-20 72.6 0.6 1.2e-19 70.4 0.1 2.5 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 KOG99178.1 - 2.7e-13 49.4 0.0 1.6e-06 27.6 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain AflR PF08493.10 KOG99178.1 - 0.00093 18.8 0.5 0.046 13.2 0.2 2.3 2 0 0 2 2 2 1 Aflatoxin regulatory protein CK2S PF15011.6 KOG99178.1 - 0.059 13.2 2.3 3 7.7 0.1 3.0 3 0 0 3 3 3 0 Casein Kinase 2 substrate SH3_3 PF08239.11 KOG99178.1 - 0.11 12.7 0.8 0.81 10.0 0.1 2.4 2 0 0 2 2 2 0 Bacterial SH3 domain SH3BP5 PF05276.14 KOG99178.1 - 0.54 10.0 11.9 0.049 13.4 1.7 3.1 3 0 0 3 3 3 0 SH3 domain-binding protein 5 (SH3BP5) FHA PF00498.26 KOG99179.1 - 2.1e-15 56.8 0.4 4.1e-15 55.9 0.4 1.6 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 KOG99179.1 - 5.2e-11 42.1 9.8 9.5e-11 41.3 9.8 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 KOG99179.1 - 1.1e-06 28.9 11.1 1.8e-06 28.1 11.1 1.4 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 KOG99179.1 - 0.0004 20.7 0.0 0.0008 19.7 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-ANAPC11 PF12861.7 KOG99179.1 - 0.0043 17.1 4.2 0.0086 16.1 4.2 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 KOG99179.1 - 0.0068 16.3 8.5 0.012 15.6 8.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOG99179.1 - 0.01 15.7 10.8 0.018 14.9 10.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOG99179.1 - 0.017 14.9 10.5 0.03 14.2 10.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOG99179.1 - 0.051 13.9 10.1 0.14 12.4 10.1 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain NESP55 PF06390.12 KOG99179.1 - 0.1 12.2 2.2 0.27 10.8 2.2 1.6 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) zf-HC5HC2H PF13771.6 KOG99179.1 - 0.11 12.8 3.7 0.21 11.8 3.7 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain Sec_GG PF07549.14 KOG99179.1 - 0.12 12.0 0.1 0.23 11.0 0.1 1.5 1 0 0 1 1 1 0 SecD/SecF GG Motif C2-set PF05790.15 KOG99179.1 - 0.21 11.8 1.4 2.5 8.4 0.1 2.4 2 0 0 2 2 2 0 Immunoglobulin C2-set domain zf-C3HC4_3 PF13920.6 KOG99179.1 - 0.25 11.2 10.9 0.41 10.5 10.9 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOG99179.1 - 0.68 10.0 9.3 1.4 9.0 9.3 1.5 1 0 0 1 1 1 0 RING-type zinc-finger CHCH PF06747.13 KOG99180.1 - 7.2e-07 29.2 7.3 1.2e-06 28.4 7.3 1.4 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 KOG99180.1 - 7.9e-05 22.8 3.8 0.00013 22.1 3.8 1.3 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type Pet191_N PF10203.9 KOG99180.1 - 0.0059 16.9 2.8 0.0084 16.4 2.8 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 COX17 PF05051.13 KOG99180.1 - 0.075 13.4 1.9 0.12 12.7 1.9 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) TPR_1 PF00515.28 KOG99181.1 - 6.7e-31 104.8 20.1 1.3e-06 27.9 0.0 10.3 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_2 PF07719.17 KOG99181.1 - 8.8e-31 103.5 15.3 4.3e-05 23.3 0.0 10.6 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_8 PF13181.6 KOG99181.1 - 8e-24 81.8 11.8 4.4e-05 23.4 0.0 10.6 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOG99181.1 - 5.9e-19 68.3 15.2 0.001 19.5 0.8 7.8 5 3 2 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOG99181.1 - 1.4e-17 63.1 17.3 5.4e-06 26.0 0.3 7.4 5 2 2 7 7 7 5 TPR repeat TPR_16 PF13432.6 KOG99181.1 - 1.1e-16 61.2 0.0 0.00026 21.6 0.0 6.2 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOG99181.1 - 6.4e-16 57.5 14.4 0.0025 18.1 0.1 7.6 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOG99181.1 - 2.4e-14 52.8 1.4 0.4 11.6 0.0 9.5 5 3 7 12 12 12 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOG99181.1 - 3.4e-13 49.7 4.4 0.004 17.4 0.1 6.7 6 2 0 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOG99181.1 - 4.2e-11 42.8 0.0 0.00015 21.8 0.0 4.7 4 1 1 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOG99181.1 - 9.9e-11 41.7 8.3 0.0096 16.1 0.0 5.4 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KOG99181.1 - 2.1e-05 24.2 7.1 0.84 9.8 0.0 6.6 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOG99181.1 - 0.00093 19.7 9.2 26 5.8 0.0 7.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_3 PF07720.12 KOG99181.1 - 0.0015 18.4 15.3 0.038 14.0 0.4 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_21 PF09976.9 KOG99181.1 - 0.0017 18.1 11.4 0.58 9.8 0.0 5.5 4 1 1 5 5 5 1 Tetratricopeptide repeat-like domain Peptidase_C37 PF05416.12 KOG99181.1 - 0.025 13.1 1.5 0.039 12.5 1.5 1.2 1 0 0 1 1 1 0 Southampton virus-type processing peptidase Androgen_recep PF02166.16 KOG99181.1 - 0.091 11.6 4.0 0.15 10.9 4.0 1.3 1 0 0 1 1 1 0 Androgen receptor DUF4810 PF16068.5 KOG99181.1 - 0.26 11.9 5.7 19 5.9 0.1 4.6 4 1 2 6 6 6 0 Domain of unknown function (DUF4810) FAM176 PF14851.6 KOG99181.1 - 0.37 10.4 1.8 1 9.0 1.8 1.7 1 0 0 1 1 1 0 FAM176 family Spt20 PF12090.8 KOG99181.1 - 0.44 10.1 8.4 1.1 8.8 8.4 1.6 1 0 0 1 1 1 0 Spt20 family Exonuc_VII_S PF02609.16 KOG99181.1 - 0.49 10.5 4.2 1.9 8.6 0.4 3.5 3 0 0 3 3 3 0 Exonuclease VII small subunit TPR_10 PF13374.6 KOG99181.1 - 2.3 8.2 5.6 4.6 7.2 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat ORC6 PF05460.13 KOG99182.1 - 4.1e-105 352.0 3.1 4.8e-105 351.7 3.1 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) YL1 PF05764.13 KOG99182.1 - 0.046 13.8 10.4 0.083 13.0 10.4 1.4 1 0 0 1 1 1 0 YL1 nuclear protein CDC45 PF02724.14 KOG99182.1 - 2 6.6 11.9 3 6.0 11.9 1.1 1 0 0 1 1 1 0 CDC45-like protein N-SET PF11764.8 KOG99183.1 - 4.6e-50 170.1 5.5 4.6e-50 170.1 5.5 3.3 4 0 0 4 4 4 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.28 KOG99183.1 - 1.7e-18 67.6 0.1 1.7e-18 67.6 0.1 4.7 4 2 0 4 4 4 1 SET domain SET_assoc PF11767.8 KOG99183.1 - 2.2e-18 65.7 0.4 2.2e-18 65.7 0.4 2.2 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated MutS_V PF00488.21 KOG99184.1 - 3.8e-67 226.0 0.0 7e-67 225.1 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KOG99184.1 - 8.3e-32 111.0 5.0 2.6e-31 109.3 5.0 1.9 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 KOG99184.1 - 1.5e-28 99.3 0.0 3.5e-28 98.1 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 KOG99184.1 - 2.2e-11 44.2 0.6 7.8e-11 42.4 0.0 2.2 2 0 0 2 2 2 1 MutS domain II AAA_23 PF13476.6 KOG99184.1 - 0.26 11.8 0.0 0.26 11.8 0.0 3.0 2 1 1 3 3 3 0 AAA domain AD PF09793.9 KOG99185.1 - 2.5e-23 82.0 0.1 4e-23 81.4 0.1 1.3 1 0 0 1 1 1 1 Anticodon-binding domain FeS_assembly_P PF01883.19 KOG99186.1 - 1.9e-08 34.3 0.0 3.1e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein NDT80_PhoG PF05224.12 KOG99187.1 - 1.8e-69 233.7 0.1 4.7e-69 232.3 0.1 1.7 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Tau95 PF09734.9 KOG99187.1 - 0.19 12.5 1.7 0.56 11.0 1.7 1.8 1 0 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain ORC6 PF05460.13 KOG99187.1 - 0.65 9.2 8.8 1 8.6 8.8 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) PIR PF00399.19 KOG99188.1 - 3.5e-07 29.6 6.5 1.1e-06 28.0 6.5 1.8 1 0 0 1 1 1 1 Yeast PIR protein repeat UPRTase PF14681.6 KOG99190.1 - 7.9e-76 254.1 0.0 9.2e-76 253.9 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 KOG99190.1 - 0.0098 15.4 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Flu_C_NS1 PF03506.13 KOG99190.1 - 0.18 11.8 0.1 0.29 11.1 0.1 1.3 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) Actin PF00022.19 KOG99191.1 - 4.1e-110 368.2 0.0 2.5e-109 365.6 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 KOG99191.1 - 0.21 10.4 0.1 4 6.2 0.0 2.4 3 0 0 3 3 3 0 MreB/Mbl protein NOA36 PF06524.12 KOG99192.1 - 0.0017 17.8 14.4 0.0017 17.8 14.4 2.6 2 0 0 2 2 2 1 NOA36 protein PH PF00169.29 KOG99192.1 - 0.012 16.1 0.8 0.012 16.1 0.8 2.8 2 1 1 3 3 3 0 PH domain IL8 PF00048.20 KOG99192.1 - 0.04 14.1 0.1 0.13 12.4 0.1 1.8 1 0 0 1 1 1 0 Small cytokines (intecrine/chemokine), interleukin-8 like PH_9 PF15410.6 KOG99192.1 - 0.048 14.0 3.8 0.72 10.2 3.8 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain Peptidase_M14 PF00246.24 KOG99193.1 - 1.6e-78 264.4 0.0 2e-78 264.2 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Endosulfine PF04667.17 KOG99194.1 - 6.5e-33 112.7 0.3 8.9e-33 112.3 0.3 1.2 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region INSIG PF07281.12 KOG99195.1 - 1.8e-19 70.3 4.8 4.5e-18 65.7 4.8 2.1 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) MNHE PF01899.16 KOG99195.1 - 0.11 12.2 3.0 0.28 10.9 3.0 1.6 1 0 0 1 1 1 0 Na+/H+ ion antiporter subunit WLM PF08325.10 KOG99196.1 - 3.1e-63 213.3 0.0 3.7e-63 213.1 0.0 1.1 1 0 0 1 1 1 1 WLM domain Mesothelin PF06060.12 KOG99196.1 - 0.0095 14.2 0.0 0.012 13.8 0.0 1.1 1 0 0 1 1 1 1 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) DUF45 PF01863.17 KOG99196.1 - 0.055 13.5 0.1 0.09 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF45 Pkinase PF00069.25 KOG99197.1 - 1.6e-26 93.3 0.0 1.6e-26 93.3 0.0 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99197.1 - 7.8e-13 48.3 0.0 7.8e-13 48.3 0.0 2.5 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOG99197.1 - 4.8e-09 35.5 0.0 4.8e-09 35.5 0.0 2.8 2 1 0 2 2 2 1 Fungal protein kinase DUF3488 PF11992.8 KOG99197.1 - 0.017 14.1 0.1 0.095 11.6 0.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3488) Med15 PF09606.10 KOG99197.1 - 6.6 5.3 74.8 9.9 4.7 74.8 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4746 PF15928.5 KOG99197.1 - 9.2 5.6 20.6 19 4.6 20.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Erythro_esteras PF05139.14 KOG99198.1 - 0.099 12.4 3.2 0.11 12.3 3.2 1.0 1 0 0 1 1 1 0 Erythromycin esterase Inj_translocase PF16928.5 KOG99198.1 - 4.5 6.7 9.7 3.3 7.1 8.1 1.5 1 1 1 2 2 2 0 DNA/protein translocase of phage P22 injectosome DUF3863 PF12979.7 KOG99199.1 - 0.084 11.7 0.0 0.098 11.5 0.0 1.0 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3863) Asparaginase PF00710.20 KOG99200.1 - 0.027 14.0 2.6 0.13 11.8 2.6 2.1 1 1 0 1 1 1 0 Asparaginase, N-terminal Far-17a_AIG1 PF04750.14 KOG99201.1 - 1.2e-12 47.6 8.4 1.4e-12 47.3 8.4 1.1 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein NADH-u_ox-rdase PF10785.9 KOG99201.1 - 0.0029 18.3 0.5 0.0095 16.6 0.2 2.1 2 1 0 2 2 2 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit HDA2-3 PF11496.8 KOG99201.1 - 0.086 12.0 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 Chs7 PF12271.8 KOG99202.1 - 4.3e-115 384.0 20.7 5e-115 383.8 20.7 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone DNA_RNApol_7kD PF03604.13 KOG99204.1 - 1e-16 60.2 1.7 1.4e-16 59.9 1.7 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit zf_UBZ PF18439.1 KOG99204.1 - 0.004 16.7 0.8 1.5 8.5 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger DZR PF12773.7 KOG99204.1 - 0.0068 16.4 0.4 0.0092 16.0 0.4 1.3 1 0 0 1 1 1 1 Double zinc ribbon TFIIS_C PF01096.18 KOG99204.1 - 0.0092 15.8 0.6 3.9 7.4 0.1 2.3 2 0 0 2 2 2 2 Transcription factor S-II (TFIIS) HypA PF01155.19 KOG99204.1 - 0.017 15.1 0.2 0.018 15.1 0.2 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 KOG99204.1 - 0.018 15.0 0.3 0.024 14.6 0.3 1.2 1 0 0 1 1 1 0 zinc-ribbons MCM_OB PF17207.3 KOG99204.1 - 0.025 14.4 0.2 0.028 14.3 0.2 1.1 1 0 0 1 1 1 0 MCM OB domain zinc_ribbon_10 PF10058.9 KOG99204.1 - 0.054 13.2 0.2 0.53 10.1 0.0 2.0 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Zn_ribbon_SprT PF17283.2 KOG99204.1 - 0.11 12.5 3.3 0.18 11.7 1.9 1.9 1 1 2 3 3 3 0 SprT-like zinc ribbon domain DUF2197 PF09963.9 KOG99204.1 - 0.11 12.8 2.2 7.7 6.9 0.2 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) DUF4428 PF14471.6 KOG99204.1 - 0.11 12.4 1.6 1.6 8.7 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4428) Ribosomal_L40e PF01020.17 KOG99204.1 - 0.11 12.4 2.7 0.15 12.0 2.7 1.2 1 0 0 1 1 1 0 Ribosomal L40e family DUF951 PF06107.11 KOG99204.1 - 0.18 11.7 1.1 2.4 8.1 0.2 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF951) Zn-ribbon_8 PF09723.10 KOG99204.1 - 0.19 11.8 3.1 0.75 10.0 3.0 1.9 1 1 2 3 3 3 0 Zinc ribbon domain Zn_ribbon_recom PF13408.6 KOG99204.1 - 0.26 11.8 2.9 4.1 8.0 0.6 2.1 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain Rubredoxin_2 PF18073.1 KOG99204.1 - 0.53 10.1 2.7 9.7 6.0 0.3 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain Ribosomal_L44 PF00935.19 KOG99204.1 - 1.4 9.5 4.7 16 6.1 0.6 2.1 1 1 1 2 2 2 0 Ribosomal protein L44 dCMP_cyt_deam_1 PF00383.23 KOG99205.1 - 6.2e-27 93.4 2.5 9.1e-27 92.9 2.5 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KOG99205.1 - 4.2e-15 55.7 0.1 8e-15 54.8 0.1 1.4 1 0 0 1 1 1 1 MafB19-like deaminase AGS_C PF18134.1 KOG99205.1 - 0.0074 16.3 0.1 0.016 15.2 0.1 1.6 1 0 0 1 1 1 1 Adenylyl/Guanylyl and SMODS C-terminal sensor domain SNAD4 PF18750.1 KOG99205.1 - 0.032 14.4 1.2 0.11 12.6 1.2 2.0 1 1 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC_N PF08210.11 KOG99205.1 - 0.08 12.8 2.6 0.25 11.2 2.6 1.8 1 1 0 1 1 1 0 APOBEC-like N-terminal domain ArsC PF03960.15 KOG99205.1 - 0.14 12.2 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 ArsC family AMPK1_CBM PF16561.5 KOG99206.1 - 4.2e-15 55.7 0.1 9e-15 54.7 0.1 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase DUF1387 PF07139.11 KOG99206.1 - 3.6 7.2 34.2 0.074 12.8 5.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) Macoilin PF09726.9 KOG99206.1 - 9 4.7 22.5 4.5 5.7 15.3 2.0 2 0 0 2 2 2 0 Macoilin family Ribosomal_L6 PF00347.23 KOG99207.1 - 7.6e-26 90.6 1.2 4.1e-16 59.4 0.3 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_S4 PF00163.19 KOG99208.1 - 1.6e-12 48.2 2.6 2.3e-12 47.7 2.5 1.5 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 KOG99208.1 - 2.6e-12 46.2 0.0 7.2e-12 44.8 0.0 1.8 2 0 0 2 2 2 1 S4 domain Baculo_gp41 PF04700.12 KOG99208.1 - 0.0028 17.4 0.2 0.0041 16.9 0.2 1.2 1 0 0 1 1 1 1 Structural glycoprotein p40/gp41 conserved region THDPS_N_2 PF14805.6 KOG99208.1 - 0.053 13.8 0.0 0.091 13.0 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal Herpes_LAMP2 PF06126.11 KOG99208.1 - 0.17 10.4 0.1 0.2 10.2 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus Latent membrane protein 2 SKG6 PF08693.10 KOG99209.1 - 2.2e-16 59.0 8.5 3.8e-16 58.2 8.5 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 KOG99209.1 - 0.00014 21.7 1.3 0.00031 20.6 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) TMEM154 PF15102.6 KOG99209.1 - 0.0002 21.3 0.2 0.0002 21.3 0.2 2.5 2 0 0 2 2 2 1 TMEM154 protein family Orf78 PF06024.12 KOG99209.1 - 0.011 16.0 0.1 0.011 16.0 0.1 3.7 4 0 0 4 4 4 0 Orf78 (ac78) EphA2_TM PF14575.6 KOG99209.1 - 0.018 15.9 0.0 0.018 15.9 0.0 2.8 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Stevor PF17410.2 KOG99209.1 - 0.021 14.4 0.1 0.37 10.3 0.0 2.5 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame 7tm_1 PF00001.21 KOG99209.1 - 0.049 13.0 0.0 0.051 12.9 0.0 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Adeno_E3_CR2 PF02439.15 KOG99209.1 - 0.061 13.1 2.7 0.1 12.4 2.7 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Chordopox_A13L PF05961.11 KOG99209.1 - 0.24 11.7 0.5 1.2 9.4 0.0 2.5 2 0 0 2 2 2 0 Chordopoxvirus A13L protein RIFIN PF02009.16 KOG99209.1 - 6.6 6.5 6.3 0.98 9.3 0.4 2.3 2 1 0 2 2 2 0 Rifin Pex24p PF06398.11 KOG99210.1 - 7.1e-74 249.0 2.5 9e-74 248.6 2.5 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin PRT_C PF08372.10 KOG99210.1 - 0.031 14.0 0.1 0.06 13.1 0.1 1.4 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal Sir1 PF11603.8 KOG99211.1 - 0.24 11.9 1.3 0.65 10.5 0.3 2.2 2 1 1 3 3 3 0 Regulatory protein Sir1 Spo12 PF05032.12 KOG99212.1 - 6.4e-16 58.0 1.8 1.6e-15 56.7 1.8 1.7 1 0 0 1 1 1 1 Spo12 family Menin PF05053.13 KOG99212.1 - 0.51 8.6 6.5 0.59 8.4 6.5 1.1 1 0 0 1 1 1 0 Menin XAP5 PF04921.14 KOG99212.1 - 4.1 7.1 14.0 0.095 12.5 7.6 1.4 2 0 0 2 2 2 0 XAP5, circadian clock regulator RTT107_BRCT_6 PF16771.5 KOG99214.1 - 8.3e-39 132.3 6.0 8.3e-39 132.3 6.0 3.3 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 KOG99214.1 - 1.2e-29 102.4 8.2 1.9e-10 41.0 0.1 5.6 5 0 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 KOG99214.1 - 5.1e-24 84.0 3.4 6.6e-24 83.7 0.1 2.9 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 KOG99214.1 - 1.9e-16 59.7 0.1 2.4e-12 46.6 0.0 3.0 3 0 0 3 3 3 2 twin BRCT domain BRCT_2 PF16589.5 KOG99214.1 - 0.0011 19.3 3.3 7.1 7.1 0.0 5.0 5 0 0 5 5 5 2 BRCT domain, a BRCA1 C-terminus domain VASt PF16016.5 KOG99215.1 - 1.5e-12 48.2 2.7 4e-12 46.8 2.7 1.7 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain PH PF00169.29 KOG99215.1 - 1.4e-09 38.4 0.4 1.4e-09 38.4 0.4 3.4 4 0 0 4 4 4 1 PH domain BAR_3 PF16746.5 KOG99215.1 - 3.6e-09 36.7 0.3 1.5e-08 34.7 0.1 2.1 1 1 0 1 1 1 1 BAR domain of APPL family FAS_N PF17828.1 KOG99215.1 - 0.0039 17.2 1.5 0.01 15.9 0.4 2.3 2 0 0 2 2 2 1 N-terminal domain in fatty acid synthase subunit beta IL3 PF02059.15 KOG99215.1 - 0.13 12.3 3.8 2.6 8.1 0.8 3.1 2 1 0 2 2 2 0 Interleukin-3 GYF PF02213.16 KOG99216.1 - 3.9e-08 32.8 3.3 1e-07 31.5 3.3 1.8 1 0 0 1 1 1 1 GYF domain REC104 PF17378.2 KOG99217.1 - 2.4e-89 298.0 5.8 2.7e-89 297.8 5.8 1.0 1 0 0 1 1 1 1 Meiotic recombination protein REC104 MPDZ_u10 PF16667.5 KOG99217.1 - 0.081 13.8 0.5 0.23 12.4 0.1 1.9 2 0 0 2 2 2 0 Unstructured region 10 on multiple PDZ protein DUF2963 PF11178.8 KOG99217.1 - 0.34 10.6 2.4 0.49 10.1 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2963) Kelch_5 PF13854.6 KOG99218.1 - 3.9e-32 109.7 5.8 1.5e-06 28.0 0.2 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KOG99218.1 - 1.3e-29 101.9 1.6 1.2e-05 25.5 0.0 5.7 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 KOG99218.1 - 5.2e-29 100.0 7.1 1.4e-05 25.0 0.1 6.6 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 KOG99218.1 - 1.9e-26 91.4 6.9 9.5e-06 25.7 0.1 6.4 4 2 2 6 6 6 5 Kelch motif Kelch_1 PF01344.25 KOG99218.1 - 5.1e-21 74.0 2.9 0.00021 20.8 0.0 5.7 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KOG99218.1 - 6.7e-15 54.4 6.3 0.0028 17.6 0.0 6.7 6 1 0 6 6 6 5 Kelch motif HALZ PF02183.18 KOG99218.1 - 0.079 13.2 39.9 0.3 11.4 4.3 6.5 6 0 0 6 6 6 0 Homeobox associated leucine zipper Prefoldin_3 PF13758.6 KOG99218.1 - 3 8.0 15.8 3.9 7.6 0.4 4.4 3 1 0 3 3 3 0 Prefoldin subunit TDA11 PF17084.5 KOG99219.1 - 2.1e-135 452.2 19.6 2.7e-135 451.9 19.6 1.1 1 0 0 1 1 1 1 Topoisomerase I damage affected protein 11 CENP-Q PF13094.6 KOG99219.1 - 0.0016 18.7 0.3 0.0042 17.3 0.3 1.7 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Lzipper-MIP1 PF14389.6 KOG99219.1 - 0.018 15.3 0.2 0.018 15.3 0.2 1.8 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DUF3597 PF12200.8 KOG99219.1 - 0.12 12.9 1.0 0.35 11.4 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) LCD1 PF09798.9 KOG99219.1 - 0.28 9.7 1.7 0.41 9.1 1.7 1.3 1 0 0 1 1 1 0 DNA damage checkpoint protein ANTH PF07651.16 KOG99221.1 - 2.7e-70 236.5 1.0 2.7e-70 236.5 1.0 1.9 2 0 0 2 2 2 1 ANTH domain ENTH PF01417.20 KOG99221.1 - 2.5e-08 34.0 0.0 8.3e-08 32.3 0.0 1.9 1 0 0 1 1 1 1 ENTH domain Nrf1_DNA-bind PF10491.9 KOG99221.1 - 0.42 10.3 4.2 1.3 8.7 4.2 1.8 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 MerR-DNA-bind PF09278.11 KOG99221.1 - 3.7 8.2 8.0 6.6 7.4 0.0 3.7 3 0 0 3 3 3 0 MerR, DNA binding MPC PF03650.13 KOG99222.1 - 1e-46 157.6 0.1 1.2e-46 157.4 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers MtN3_slv PF03083.16 KOG99222.1 - 0.0052 16.8 0.1 0.0077 16.3 0.1 1.2 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange Glucosamine_iso PF01182.20 KOG99223.1 - 7.6e-61 205.9 0.0 8.6e-61 205.7 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Dna2 PF08696.11 KOG99224.1 - 3.5e-55 187.0 0.6 1.9e-54 184.6 0.1 2.6 2 0 0 2 2 2 1 DNA replication factor Dna2 AAA_12 PF13087.6 KOG99224.1 - 3e-50 170.6 0.1 8.4e-50 169.2 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOG99224.1 - 3.3e-28 99.2 0.1 4.7e-16 59.4 0.0 4.1 3 1 1 4 4 4 2 AAA domain AAA_30 PF13604.6 KOG99224.1 - 6.5e-14 52.1 0.0 1.4e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOG99224.1 - 3.9e-11 43.5 0.0 9.2e-11 42.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KOG99224.1 - 3e-05 23.9 0.1 0.23 11.2 0.3 3.9 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase PDDEXK_1 PF12705.7 KOG99224.1 - 3.2e-05 24.0 0.0 6.8e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily PIF1 PF05970.14 KOG99224.1 - 9.3e-05 21.8 0.0 0.00028 20.2 0.0 1.7 1 1 0 1 1 1 1 PIF1-like helicase Helicase_RecD PF05127.14 KOG99224.1 - 0.00027 20.9 0.0 0.00079 19.3 0.0 1.9 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 KOG99224.1 - 0.0013 18.4 0.0 0.0013 18.4 0.0 2.9 2 1 0 2 2 1 1 UvrD/REP helicase N-terminal domain SRP54 PF00448.22 KOG99224.1 - 0.002 17.8 0.0 0.0049 16.5 0.0 1.7 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain DUF2075 PF09848.9 KOG99224.1 - 0.01 15.1 0.0 0.024 13.9 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 KOG99224.1 - 0.011 16.1 0.0 0.031 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 KOG99224.1 - 0.032 14.2 0.3 0.098 12.6 0.3 1.9 1 0 0 1 1 1 0 NTPase AAA_24 PF13479.6 KOG99224.1 - 0.032 14.0 0.1 0.081 12.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain Cas_Cas4 PF01930.17 KOG99224.1 - 0.032 14.3 4.8 0.046 13.8 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function DUF83 AAA_7 PF12775.7 KOG99224.1 - 0.033 13.7 0.1 0.086 12.3 0.1 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 KOG99224.1 - 0.04 14.5 1.0 0.12 12.9 0.0 2.3 2 0 0 2 2 1 0 AAA domain ResIII PF04851.15 KOG99224.1 - 0.056 13.4 0.1 0.056 13.4 0.1 2.8 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit UvrD_C_2 PF13538.6 KOG99224.1 - 0.057 13.2 0.0 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain YkuI_C PF10388.9 KOG99224.1 - 0.06 13.1 0.1 0.26 11.1 0.1 2.1 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain AAA PF00004.29 KOG99224.1 - 0.065 13.7 0.0 0.28 11.6 0.0 2.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 KOG99224.1 - 0.068 12.6 0.1 2.5 7.5 0.0 2.6 3 0 0 3 3 2 0 PhoH-like protein MobB PF03205.14 KOG99224.1 - 0.079 12.9 0.1 0.19 11.6 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.23 KOG99224.1 - 0.08 13.0 0.0 0.29 11.2 0.0 2.0 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_5 PF07728.14 KOG99224.1 - 0.1 12.6 0.2 0.62 10.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOG99224.1 - 0.12 12.7 0.2 1.3 9.3 0.1 2.8 2 1 0 2 2 2 0 AAA domain MeaB PF03308.16 KOG99224.1 - 0.15 11.1 0.2 0.42 9.6 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_31 PF13614.6 KOG99224.1 - 0.57 10.1 4.2 0.29 11.0 0.8 2.3 2 0 0 2 2 1 0 AAA domain cobW PF02492.19 KOG99224.1 - 0.65 9.6 3.7 0.52 9.9 0.0 2.7 5 0 0 5 5 2 0 CobW/HypB/UreG, nucleotide-binding domain PROCN PF08083.11 KOG99226.1 - 8e-220 729.6 12.7 1.4e-219 728.8 12.7 1.4 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 KOG99226.1 - 1.3e-121 404.5 1.4 1.3e-121 404.5 1.4 1.9 2 0 0 2 2 2 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 KOG99226.1 - 7.2e-85 282.8 1.2 2.4e-84 281.1 1.2 2.0 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 KOG99226.1 - 1.6e-80 268.4 2.2 4.4e-80 267.0 2.2 1.9 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 KOG99226.1 - 1.6e-70 235.4 0.0 4.2e-70 234.0 0.0 1.8 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 KOG99226.1 - 2.6e-47 159.1 0.4 8.3e-47 157.5 0.4 2.0 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 KOG99226.1 - 1e-46 157.8 0.0 2.2e-46 156.8 0.0 1.6 1 0 0 1 1 1 1 PROCT (NUC072) domain TPD PF14811.6 KOG99226.1 - 0.0047 16.8 0.2 0.017 15.0 0.2 1.9 1 0 0 1 1 1 1 Protein of unknown function TPD sequence-motif ANAPC8 PF04049.13 KOG99227.1 - 1.5e-36 125.5 1.1 2.7e-36 124.7 0.0 2.0 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_8 PF13181.6 KOG99227.1 - 2.6e-27 92.7 15.8 6.3e-05 22.9 0.1 8.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.28 KOG99227.1 - 5.3e-26 89.3 14.6 0.00046 19.9 0.0 8.2 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOG99227.1 - 1.5e-20 71.6 13.7 0.045 13.9 0.1 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 KOG99227.1 - 8e-15 54.2 0.6 5.7e-08 32.3 0.0 5.0 3 2 2 5 5 5 2 TPR repeat TPR_14 PF13428.6 KOG99227.1 - 9.3e-15 54.1 0.3 0.00046 20.8 0.0 7.8 6 2 3 9 9 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOG99227.1 - 6.8e-11 42.3 11.3 0.00049 20.3 0.1 6.0 2 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOG99227.1 - 2e-09 37.2 10.6 0.0072 16.6 0.0 7.4 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOG99227.1 - 4.4e-08 33.6 2.8 0.0008 20.0 0.0 5.9 7 1 1 8 8 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOG99227.1 - 6.8e-08 32.9 1.9 0.58 10.7 0.0 6.4 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOG99227.1 - 9.4e-08 31.6 2.0 0.2 11.8 0.1 5.3 4 1 1 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOG99227.1 - 1.3e-06 28.5 21.7 0.05 13.8 0.1 6.4 5 1 3 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.10 KOG99227.1 - 4.9e-06 25.8 0.0 3.5e-05 23.0 0.0 2.1 1 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_15 PF13429.6 KOG99227.1 - 6.1e-05 22.4 0.3 0.27 10.4 0.1 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat RPN7 PF10602.9 KOG99227.1 - 9.6e-05 22.1 0.3 9.6e-05 22.1 0.3 3.2 3 1 0 3 3 3 1 26S proteasome subunit RPN7 TPR_6 PF13174.6 KOG99227.1 - 0.00089 19.7 15.5 3.7 8.4 0.1 8.3 9 0 0 9 9 9 1 Tetratricopeptide repeat BTAD PF03704.17 KOG99227.1 - 0.033 14.6 0.0 0.16 12.4 0.0 2.1 1 1 1 2 2 2 0 Bacterial transcriptional activator domain TPR_9 PF13371.6 KOG99227.1 - 0.037 14.2 0.1 0.33 11.1 0.0 2.6 1 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOG99227.1 - 0.08 12.8 3.4 3.9 7.5 0.0 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat Flp_N PF03930.14 KOG99227.1 - 0.31 11.0 2.6 1 9.4 0.2 2.5 2 0 0 2 2 2 0 Recombinase Flp protein N-terminus THP2 PF09432.10 KOG99228.1 - 3.1e-55 185.7 2.5 3.1e-55 185.7 2.5 1.7 2 0 0 2 2 2 1 Tho complex subunit THP2 Retrotrans_gag PF03732.17 KOG99228.1 - 0.035 14.4 2.4 0.14 12.5 0.3 2.7 2 1 0 2 2 2 0 Retrotransposon gag protein MRP-S28 PF10213.9 KOG99228.1 - 0.17 12.3 1.9 0.39 11.1 0.1 2.3 2 1 1 3 3 3 0 Mitochondrial ribosomal subunit protein BLI1 PF17324.2 KOG99228.1 - 5.3 7.8 10.3 22 5.8 0.1 4.0 3 1 0 3 3 3 0 BLOC-1 interactor 1 GTP1_OBG PF01018.22 KOG99229.1 - 3.5e-34 117.6 4.0 1.6e-24 86.3 2.3 2.5 3 0 0 3 3 3 2 GTP1/OBG MMR_HSR1 PF01926.23 KOG99229.1 - 2.8e-21 75.7 0.0 4.5e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOG99229.1 - 2.1e-11 43.6 0.0 3.2e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 KOG99229.1 - 8.1e-09 35.2 0.2 2.1e-08 33.8 0.2 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KOG99229.1 - 0.04 13.4 0.0 0.092 12.2 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ID PF18543.1 KOG99229.1 - 0.046 13.7 0.5 0.11 12.5 0.5 1.6 1 0 0 1 1 1 0 Intracellular delivery domain MMR_HSR1_Xtn PF16897.5 KOG99229.1 - 0.052 13.6 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 KOG99229.1 - 0.081 12.8 0.5 5.6 6.8 0.1 2.3 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 KOG99229.1 - 0.17 11.4 0.2 13 5.2 0.1 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DEAD PF00270.29 KOG99230.1 - 2.2e-40 138.3 0.1 6.7e-40 136.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG99230.1 - 1.3e-31 109.2 0.4 7e-31 106.9 0.1 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG99230.1 - 0.0008 19.5 0.1 0.0026 17.8 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit NMD3 PF04981.13 KOG99231.1 - 1.2e-81 273.7 1.7 2.1e-81 273.0 1.7 1.4 1 0 0 1 1 1 1 NMD3 family zf-Mss51 PF13824.6 KOG99231.1 - 0.092 12.9 1.2 3.3 7.9 0.4 2.9 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 DZR PF12773.7 KOG99231.1 - 0.12 12.5 6.0 9.3 6.4 6.0 2.7 1 1 0 1 1 1 0 Double zinc ribbon VPS11_C PF12451.8 KOG99231.1 - 0.75 10.1 2.3 2.1 8.7 2.3 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal HypA PF01155.19 KOG99231.1 - 2.2 8.3 6.4 14 5.7 0.0 2.6 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ATG7_N PF16420.5 KOG99232.1 - 2e-55 188.6 1.1 3.9e-55 187.6 1.1 1.5 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 KOG99232.1 - 1.3e-48 165.5 0.0 2e-48 164.9 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 KOG99232.1 - 0.0016 18.5 0.0 0.075 13.1 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase GCP_N_terminal PF17681.1 KOG99233.1 - 3.8e-31 108.8 1.4 3.8e-31 108.8 1.4 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 KOG99233.1 - 6.4e-15 55.4 2.7 1.3e-14 54.4 2.7 1.6 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal FTO_CTD PF12934.7 KOG99233.1 - 0.035 13.9 1.2 1.6 8.5 0.0 2.6 2 0 0 2 2 2 0 FTO C-terminal domain Enolase_C PF00113.22 KOG99234.1 - 8.5e-150 497.9 0.0 1.2e-149 497.4 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 KOG99234.1 - 4e-55 185.6 0.3 7.2e-55 184.7 0.3 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 KOG99234.1 - 8.6e-07 28.7 0.0 1.7e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 KOG99234.1 - 0.016 14.4 0.2 0.052 12.7 0.0 1.8 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus Ctr PF04145.15 KOG99235.1 - 3e-25 89.6 11.4 4.1e-23 82.7 11.4 2.0 1 1 0 1 1 1 1 Ctr copper transporter family DUF2070 PF09843.9 KOG99235.1 - 0.096 11.0 0.2 0.12 10.7 0.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Fzo_mitofusin PF04799.13 KOG99235.1 - 0.38 10.3 0.1 0.38 10.3 0.1 1.9 2 0 0 2 2 2 0 fzo-like conserved region FMO-like PF00743.19 KOG99236.1 - 1.2e-39 136.1 0.9 1.4e-31 109.6 0.1 2.2 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 KOG99236.1 - 8.6e-21 74.5 0.3 3.5e-18 65.9 0.3 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOG99236.1 - 2.9e-15 56.3 0.0 7.4e-14 51.7 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOG99236.1 - 4.2e-12 46.3 0.2 4.1e-09 36.6 0.0 3.3 2 2 1 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 KOG99236.1 - 3e-06 27.1 0.0 0.0079 15.8 0.0 3.2 3 0 0 3 3 3 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 KOG99236.1 - 4.9e-06 25.9 2.3 0.0012 18.0 0.1 3.2 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KOG99236.1 - 1.1e-05 25.5 0.0 3.8e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KOG99236.1 - 0.00093 18.5 0.0 0.059 12.6 0.0 2.2 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 KOG99236.1 - 0.0012 17.7 0.3 0.79 8.3 0.0 2.8 3 0 0 3 3 3 2 HI0933-like protein Pyr_redox PF00070.27 KOG99236.1 - 0.0018 18.8 0.2 9.4 6.9 0.0 3.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOG99236.1 - 0.043 12.9 0.6 0.99 8.4 0.0 2.5 3 0 0 3 3 3 0 Glucose inhibited division protein A Prenylcys_lyase PF07156.14 KOG99236.1 - 0.061 12.4 0.6 0.12 11.5 0.0 1.7 2 0 0 2 2 2 0 Prenylcysteine lyase Fungal_trans PF04082.18 KOG99237.1 - 1e-24 87.0 0.1 1e-24 87.0 0.1 2.7 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG99237.1 - 6.4e-08 32.6 11.2 1.2e-07 31.8 11.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Oxidored_FMN PF00724.20 KOG99238.1 - 5.9e-141 469.7 0.0 6.8e-141 469.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Ribosomal_L30_N PF08079.12 KOG99238.1 - 0.1 12.9 2.0 0.23 11.7 2.0 1.5 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain Erv26 PF04148.13 KOG99239.1 - 2.4e-87 292.1 3.5 2.7e-87 291.9 3.5 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 DUF996 PF06195.13 KOG99239.1 - 0.0021 18.4 1.6 0.0021 18.4 1.6 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF996) HOASN PF14515.6 KOG99239.1 - 0.17 12.3 0.0 0.33 11.4 0.0 1.4 1 0 0 1 1 1 0 Haem-oxygenase-associated N-terminal helices Cytochrom_C_asm PF01578.20 KOG99239.1 - 0.41 10.4 5.9 0.089 12.5 1.3 2.1 1 1 1 2 2 2 0 Cytochrome C assembly protein UbiA PF01040.18 KOG99239.1 - 8.9 5.5 14.6 1.5 8.1 9.6 2.0 1 1 1 2 2 2 0 UbiA prenyltransferase family RhoGAP PF00620.27 KOG99240.1 - 0.002 17.9 2.9 0.0022 17.8 0.1 2.5 3 0 0 3 3 3 1 RhoGAP domain AHSP PF09236.10 KOG99240.1 - 0.13 12.8 1.2 0.39 11.2 0.1 2.5 3 0 0 3 3 3 0 Alpha-haemoglobin stabilising protein 6PGD PF00393.19 KOG99241.1 - 1.4e-126 421.7 0.0 1.8e-126 421.4 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 KOG99241.1 - 5e-51 173.0 0.0 7.3e-51 172.5 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 KOG99241.1 - 0.053 14.1 0.1 0.11 13.1 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_11 PF14833.6 KOG99241.1 - 0.069 13.4 0.0 0.23 11.7 0.0 1.9 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.19 KOG99241.1 - 0.11 11.8 0.1 0.39 10.1 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TetR_C_27 PF17935.1 KOG99242.1 - 0.096 12.7 0.5 13 5.9 0.0 2.9 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Raptor_N PF14538.6 KOG99244.1 - 1.7e-66 222.7 0.0 1.7e-66 222.7 0.0 2.9 3 0 0 3 3 3 1 Raptor N-terminal CASPase like domain BBS2_Mid PF14783.6 KOG99244.1 - 2.4e-06 27.6 0.0 0.0016 18.4 0.0 3.1 2 0 0 2 2 2 2 Ciliary BBSome complex subunit 2, middle region HEAT PF02985.22 KOG99244.1 - 5.8e-06 26.1 0.0 0.012 15.8 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat WD40 PF00400.32 KOG99244.1 - 1.1e-05 26.1 3.2 0.36 11.8 0.0 6.1 5 2 1 6 6 6 1 WD domain, G-beta repeat HEAT_2 PF13646.6 KOG99244.1 - 0.027 14.9 0.0 0.23 11.9 0.0 2.5 2 0 0 2 2 2 0 HEAT repeats Cnd1 PF12717.7 KOG99244.1 - 0.42 10.6 5.2 1.1 9.2 2.4 2.5 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Mt_ATP-synt_D PF05873.12 KOG99244.1 - 1.2 8.9 6.5 3.7 7.4 6.5 1.8 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Exonuc_VII_L PF02601.15 KOG99244.1 - 2.1 7.8 15.9 0.021 14.4 4.7 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit Elong_Iki1 PF10483.9 KOG99245.1 - 9.1e-77 258.5 0.1 1e-76 258.3 0.1 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 Gpi16 PF04113.14 KOG99246.1 - 6e-176 586.2 0.0 7.7e-176 585.8 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Pept_tRNA_hydro PF01195.19 KOG99247.1 - 3.5e-36 124.7 0.0 4e-36 124.5 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase SQS_PSY PF00494.19 KOG99248.1 - 8.3e-41 140.2 0.0 1e-40 139.9 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase PAS_12 PF18095.1 KOG99248.1 - 0.087 12.5 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 UPF0242 C-terminal PAS-like domain DYW_deaminase PF14432.6 KOG99248.1 - 0.2 11.5 0.4 11 5.9 0.0 2.7 2 1 1 3 3 3 0 DYW family of nucleic acid deaminases Ctf8 PF09696.10 KOG99249.1 - 8.1e-23 81.3 1.6 1.6e-20 73.9 1.6 2.3 1 1 0 1 1 1 1 Ctf8 zinc_ribbon_10 PF10058.9 KOG99250.1 - 5.9e-14 51.5 0.4 1.1e-13 50.7 0.4 1.4 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein Adaptin_binding PF10199.9 KOG99250.1 - 0.021 15.4 0.2 0.082 13.5 0.0 1.9 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 DUF1772 PF08592.11 KOG99250.1 - 0.071 13.4 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) PhnA_Zn_Ribbon PF08274.12 KOG99250.1 - 0.097 12.6 3.5 2.1 8.4 0.2 2.4 2 0 0 2 2 2 0 PhnA Zinc-Ribbon Zn_Tnp_IS1595 PF12760.7 KOG99250.1 - 0.18 11.8 5.1 0.43 10.6 5.1 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DUF2197 PF09963.9 KOG99250.1 - 0.45 10.8 2.4 0.45 10.8 0.3 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) FYDLN_acid PF09538.10 KOG99250.1 - 0.55 10.9 10.0 0.077 13.7 2.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF641 PF04859.12 KOG99250.1 - 0.91 9.9 7.0 0.59 10.5 4.7 1.8 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) NBP1 PF08537.10 KOG99250.1 - 1.5 8.1 9.6 1 8.7 7.0 1.8 2 0 0 2 2 2 0 Fungal Nap binding protein NBP1 NAC PF01849.18 KOG99251.1 - 6.5e-19 67.7 1.4 9.3e-19 67.2 0.3 1.8 2 0 0 2 2 2 1 NAC domain UBA_4 PF14555.6 KOG99251.1 - 0.00063 19.5 0.1 0.0017 18.1 0.1 1.8 1 0 0 1 1 1 1 UBA-like domain TMF_DNA_bd PF12329.8 KOG99251.1 - 0.17 11.9 0.1 0.17 11.9 0.1 3.2 4 0 0 4 4 4 0 TATA element modulatory factor 1 DNA binding MDM31_MDM32 PF08118.11 KOG99252.1 - 6.8e-221 734.5 8.8 1.9e-220 733.0 8.8 1.6 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins PD40 PF07676.12 KOG99254.1 - 0.0016 18.3 0.3 10 6.2 0.0 3.5 3 0 0 3 3 3 3 WD40-like Beta Propeller Repeat Utp12 PF04003.12 KOG99254.1 - 0.0025 18.1 1.5 0.0045 17.3 1.5 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family RIX1 PF08167.12 KOG99255.1 - 3.4e-46 157.4 5.8 5.3e-46 156.7 3.8 2.1 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis Chalcone_2 PF16035.5 KOG99256.1 - 3.9e-61 206.4 0.2 4.9e-61 206.1 0.2 1.1 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 KOG99256.1 - 2.6e-05 24.4 2.1 0.0021 18.2 0.3 2.2 1 1 1 2 2 2 2 Chalcone isomerase-like Chalcone_2 PF16035.5 KOG99257.1 - 2.1e-49 168.1 0.0 2.6e-49 167.8 0.0 1.1 1 0 0 1 1 1 1 Chalcone isomerase like DUF2789 PF10982.8 KOG99258.1 - 0.059 13.5 0.9 0.074 13.2 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2789) DUF2205 PF10224.9 KOG99258.1 - 0.83 9.7 7.4 0.19 11.8 2.8 1.9 1 1 1 2 2 2 0 Short coiled-coil protein Fer4_24 PF18109.1 KOG99258.1 - 6.5 7.1 8.9 1 9.7 2.1 2.5 2 1 0 2 2 2 0 Ferredoxin I 4Fe-4S cluster domain VWA_2 PF13519.6 KOG99259.1 - 2.5e-19 69.9 1.2 8.1e-19 68.2 0.0 2.2 2 1 1 3 3 3 1 von Willebrand factor type A domain Ssl1 PF04056.14 KOG99259.1 - 2.6e-06 27.4 0.0 3.7e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like VWA PF00092.28 KOG99259.1 - 0.0016 18.7 0.1 0.0023 18.2 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Aminotran_1_2 PF00155.21 KOG99259.1 - 0.042 13.0 0.0 3 6.9 0.0 2.1 2 0 0 2 2 2 0 Aminotransferase class I and II DHHA2 PF02833.14 KOG99260.1 - 3.6e-32 111.5 0.2 6.6e-32 110.7 0.2 1.4 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 KOG99260.1 - 7e-08 32.6 0.0 1.3e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 DHH family PMT PF02366.18 KOG99261.1 - 1.1e-71 241.3 10.8 1.1e-71 241.3 10.8 1.8 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 KOG99261.1 - 2.6e-55 187.1 5.0 2.6e-55 187.1 5.0 2.9 2 1 1 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 KOG99261.1 - 2.9e-14 53.4 0.3 4.8e-14 52.6 0.3 1.4 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 KOG99261.1 - 9e-08 32.5 5.9 9e-08 32.5 5.9 2.6 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF5482 PF17579.2 KOG99262.1 - 0.064 13.1 0.5 0.16 11.9 0.2 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5482) MRI PF15325.6 KOG99262.1 - 0.071 14.2 0.1 0.13 13.4 0.1 1.4 1 0 0 1 1 1 0 Modulator of retrovirus infection Ribosomal_S4e PF00900.20 KOG99263.1 - 6.6e-40 134.9 0.7 3.7e-38 129.3 0.5 2.3 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 KOG99263.1 - 1.3e-26 91.9 0.1 2.7e-26 91.0 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus KOW PF00467.29 KOG99263.1 - 2.7e-06 27.1 1.8 2.7e-06 27.1 1.8 3.2 4 0 0 4 4 4 1 KOW motif S4 PF01479.25 KOG99263.1 - 0.00016 21.3 0.2 0.00038 20.1 0.0 1.8 2 0 0 2 2 2 1 S4 domain Sipho_tail PF05709.11 KOG99263.1 - 0.052 13.0 0.1 0.1 12.0 0.1 1.6 1 1 0 1 1 1 0 Phage tail protein dCache_2 PF08269.11 KOG99263.1 - 0.15 11.3 0.0 0.29 10.3 0.0 1.5 1 1 0 1 1 1 0 Cache domain Glyco_hydro_47 PF01532.20 KOG99264.1 - 1.6e-107 360.3 0.0 2.1e-107 359.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Pkinase PF00069.25 KOG99265.1 - 1.2e-67 228.1 0.1 3.3e-67 226.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99265.1 - 2.1e-30 105.9 0.0 3.1e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG99265.1 - 6.3e-10 38.8 0.0 5.8e-09 35.7 0.0 2.1 1 1 0 2 2 2 1 Kinase-like C2 PF00168.30 KOG99265.1 - 1.6e-09 38.0 0.0 0.001 19.3 0.0 2.7 2 0 0 2 2 2 2 C2 domain Pkinase_C PF00433.24 KOG99265.1 - 1.9e-09 38.1 2.2 1.9e-09 38.1 2.2 2.4 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 KOG99265.1 - 0.00053 19.0 6.4 0.0036 16.3 0.1 2.4 2 0 0 2 2 2 1 Haspin like kinase domain FTA2 PF13095.6 KOG99265.1 - 0.0076 15.9 0.2 0.39 10.3 0.1 2.4 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Adeno_E3_15_3 PF03307.14 KOG99265.1 - 0.043 13.8 0.1 0.081 12.9 0.1 1.4 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region Kdo PF06293.14 KOG99265.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HSF_DNA-bind PF00447.17 KOG99266.1 - 5.4e-29 100.7 3.0 1.2e-28 99.5 3.0 1.7 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.24 KOG99266.1 - 4.8e-27 94.4 0.3 1.9e-26 92.4 0.3 2.0 2 0 0 2 2 2 1 Response regulator receiver domain SET PF00856.28 KOG99267.1 - 2.3e-15 57.4 3.8 1.6e-13 51.4 3.8 2.7 1 1 0 1 1 1 1 SET domain Aminotran_4 PF01063.19 KOG99268.1 - 4.5e-34 118.3 0.0 5.7e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Zn_clus PF00172.18 KOG99269.1 - 8.3e-08 32.2 10.4 1.7e-07 31.2 10.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF554 PF04474.12 KOG99269.1 - 0.075 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF554) Methyltransf_11 PF08241.12 KOG99270.1 - 2.5e-18 66.5 0.0 4e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOG99270.1 - 3.8e-17 62.8 0.0 7.7e-17 61.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOG99270.1 - 7.5e-14 52.3 0.0 2.3e-13 50.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOG99270.1 - 1.8e-13 50.6 0.0 2.8e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOG99270.1 - 9.9e-09 35.2 0.0 1.6e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOG99270.1 - 1.7e-06 27.6 0.0 3.4e-06 26.6 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 KOG99270.1 - 7.7e-05 22.1 0.0 0.00016 21.0 0.0 1.4 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 KOG99270.1 - 0.015 14.9 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_9 PF08003.11 KOG99270.1 - 0.072 12.0 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_32 PF13679.6 KOG99270.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain RhoGEF PF00621.20 KOG99270.1 - 0.15 12.3 0.0 0.29 11.4 0.0 1.6 1 1 0 1 1 1 0 RhoGEF domain Alkyl_sulf_dimr PF14863.6 KOG99271.1 - 7.8e-58 194.9 0.8 1.3e-57 194.2 0.8 1.4 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Lactamase_B PF00753.27 KOG99271.1 - 2.5e-42 145.1 0.2 4.7e-42 144.2 0.2 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Alkyl_sulf_C PF14864.6 KOG99271.1 - 2.8e-32 111.6 0.5 4.9e-32 110.9 0.5 1.4 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2 PF02036.17 KOG99271.1 - 6e-06 26.7 0.0 1.5e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 SCP-2 sterol transfer family Lactamase_B_2 PF12706.7 KOG99271.1 - 9.8e-05 22.0 0.0 0.0002 20.9 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain MFS_1 PF07690.16 KOG99272.1 - 2e-16 59.9 15.3 2.7e-16 59.5 15.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4500 PF14937.6 KOG99272.1 - 0.077 13.0 0.0 0.25 11.4 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) Sugar_tr PF00083.24 KOG99273.1 - 1.7e-92 310.7 5.9 1.9e-92 310.5 5.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG99273.1 - 1.3e-19 70.4 8.7 1.7e-19 70.0 8.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 KOG99273.1 - 4.9e-05 22.0 2.4 6.7e-05 21.5 2.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 KOG99273.1 - 0.00021 20.0 1.3 0.00021 20.0 1.3 2.6 3 0 0 3 3 3 1 MFS/sugar transport protein MFS_3 PF05977.13 KOG99273.1 - 0.029 12.8 2.3 0.039 12.3 2.3 1.1 1 0 0 1 1 1 0 Transmembrane secretion effector Pox_A14 PF05767.12 KOG99273.1 - 0.17 12.0 2.1 0.44 10.7 0.0 2.2 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 ATG22 PF11700.8 KOG99273.1 - 0.46 9.1 6.6 0.71 8.4 6.6 1.3 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like Gpr1_Fun34_YaaH PF01184.19 KOG99274.1 - 3.1e-69 232.7 14.2 3.8e-69 232.4 14.2 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Asp PF00026.23 KOG99275.1 - 3.4e-59 200.8 6.4 3.4e-59 200.8 6.4 2.1 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOG99275.1 - 2.2e-10 41.1 3.1 2.2e-10 41.1 3.1 2.6 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 KOG99275.1 - 4.8e-07 30.3 0.1 0.16 12.7 0.0 3.5 3 0 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 KOG99275.1 - 6.7e-06 26.6 0.2 0.82 10.3 0.0 3.6 3 1 0 3 3 3 2 gag-polyprotein putative aspartyl protease Aldose_epim PF01263.20 KOG99276.1 - 5e-74 249.3 0.1 5.6e-74 249.2 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Pyr_redox_2 PF07992.14 KOG99277.1 - 6.5e-26 91.2 0.0 8.1e-26 90.9 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOG99277.1 - 2.7e-14 53.5 0.1 2.2e-10 41.0 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOG99277.1 - 0.0012 18.9 0.0 0.33 10.9 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 KOG99277.1 - 0.0055 16.3 0.0 0.15 11.6 0.2 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 KOG99277.1 - 0.0098 15.1 0.0 6.3 5.8 0.0 3.0 1 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Shikimate_DH PF01488.20 KOG99277.1 - 0.082 13.0 0.1 2.3 8.3 0.0 2.8 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase NAD_binding_8 PF13450.6 KOG99277.1 - 0.1 12.8 0.3 1.1 9.5 0.1 2.6 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain ABC2_membrane PF01061.24 KOG99278.1 - 3.4e-62 209.6 66.7 2.6e-38 131.6 21.3 2.8 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 KOG99278.1 - 2.6e-39 134.9 0.0 5.8e-19 69.0 0.1 2.9 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 KOG99278.1 - 4.6e-37 125.8 12.3 2e-31 107.7 0.0 3.7 3 0 0 3 3 3 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 KOG99278.1 - 2.9e-16 59.5 33.8 4.8e-14 52.2 7.5 3.1 2 1 0 2 2 2 2 ABC-2 family transporter protein ABC_trans_N PF14510.6 KOG99278.1 - 6.9e-07 29.8 0.1 2.2e-06 28.2 0.0 1.9 2 0 0 2 2 1 1 ABC-transporter N-terminal AAA_21 PF13304.6 KOG99278.1 - 8.2e-06 25.8 0.0 0.001 18.9 0.0 2.3 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KOG99278.1 - 1.3e-05 25.2 1.1 0.00082 19.3 0.1 2.6 2 1 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 KOG99278.1 - 7.3e-05 23.2 0.1 0.023 15.1 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 KOG99278.1 - 0.00046 20.3 0.1 0.087 12.9 0.2 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 KOG99278.1 - 0.0029 17.3 0.3 0.12 12.1 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 KOG99278.1 - 0.0029 17.9 0.6 0.011 16.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 KOG99278.1 - 0.0095 15.4 0.0 2.4 7.5 0.0 3.2 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain cobW PF02492.19 KOG99278.1 - 0.034 13.7 0.3 0.08 12.5 0.3 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 KOG99278.1 - 0.045 14.3 0.1 0.32 11.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KOG99278.1 - 0.056 13.0 0.1 0.15 11.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KOG99278.1 - 0.062 13.5 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Phage_holin_1 PF04531.13 KOG99278.1 - 0.073 13.6 0.1 0.67 10.5 0.1 2.6 2 0 0 2 2 2 0 Bacteriophage holin AAA_23 PF13476.6 KOG99278.1 - 0.078 13.5 0.7 0.18 12.3 0.0 1.9 2 0 0 2 2 1 0 AAA domain NACHT PF05729.12 KOG99278.1 - 0.1 12.5 0.4 0.32 10.9 0.1 2.0 2 0 0 2 2 2 0 NACHT domain Septin PF00735.18 KOG99278.1 - 0.13 11.5 0.0 0.27 10.5 0.0 1.5 1 0 0 1 1 1 0 Septin AAA_33 PF13671.6 KOG99278.1 - 0.14 12.4 0.0 0.36 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 KOG99278.1 - 0.15 12.1 1.1 0.25 11.4 0.1 1.9 2 0 0 2 2 1 0 Dynamin family TrpP PF17099.5 KOG99278.1 - 0.22 11.3 4.2 5.8 6.6 0.1 2.8 2 0 0 2 2 2 0 Tryptophan transporter TrpP AAA_30 PF13604.6 KOG99278.1 - 0.99 9.1 2.5 3.3 7.4 0.2 2.2 2 0 0 2 2 2 0 AAA domain Sir1 PF11603.8 KOG99280.1 - 3.8e-19 69.3 2.1 3.8e-19 69.3 2.1 1.5 2 0 0 2 2 2 1 Regulatory protein Sir1 DUF3381 PF11861.8 KOG99280.1 - 0.062 13.1 0.1 0.14 11.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) ADH_zinc_N PF00107.26 KOG99281.1 - 4e-14 52.7 0.0 6.6e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOG99281.1 - 0.0022 17.9 0.1 0.11 12.4 0.0 2.5 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 KOG99281.1 - 0.0048 18.0 0.0 0.0077 17.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Semialdhyde_dh PF01118.24 KOG99281.1 - 0.084 13.3 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Zip PF02535.22 KOG99282.1 - 1.4e-67 228.3 3.4 1.6e-67 228.1 3.4 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter zf-C2H2 PF00096.26 KOG99283.1 - 1.6e-09 37.7 33.1 2.9e-05 24.3 0.5 6.1 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG99283.1 - 1.8e-07 31.4 28.0 0.00053 20.6 0.9 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOG99283.1 - 3e-06 27.4 12.1 0.0033 17.6 0.2 4.1 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOG99283.1 - 5.7e-06 26.5 10.1 0.042 14.2 0.5 5.4 5 1 1 6 6 6 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 KOG99283.1 - 8.2e-06 26.0 25.7 0.0064 16.9 0.2 5.2 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 KOG99283.1 - 0.01 15.8 0.9 0.01 15.8 0.9 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.12 KOG99283.1 - 0.34 11.2 14.5 3.8 7.9 0.0 4.2 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Hexokinase_2 PF03727.16 KOG99284.1 - 4.3e-78 262.1 0.0 6.2e-78 261.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KOG99284.1 - 8.7e-71 237.9 0.0 1.2e-70 237.4 0.0 1.2 1 0 0 1 1 1 1 Hexokinase FGGY_N PF00370.21 KOG99284.1 - 0.035 13.7 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Sec63 PF02889.16 KOG99285.1 - 2e-30 105.8 0.4 3.4e-30 105.1 0.4 1.3 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 KOG99285.1 - 6.7e-27 94.4 0.1 7.9e-26 90.9 0.0 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 KOG99285.1 - 6.7e-14 52.2 0.1 5e-13 49.4 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOG99285.1 - 9.2e-11 42.1 0.1 2.5e-09 37.4 0.0 3.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOG99285.1 - 0.0012 19.1 0.0 0.0092 16.3 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOG99285.1 - 0.016 15.5 0.0 0.075 13.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 KOG99285.1 - 0.057 13.2 0.0 0.22 11.3 0.0 2.1 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 KOG99285.1 - 0.057 12.5 0.1 0.17 10.9 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF1160 PF06648.11 KOG99285.1 - 0.065 13.2 0.5 1 9.4 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1160) GAPT PF11770.8 KOG99285.1 - 0.072 12.9 0.5 3.4 7.5 0.0 3.4 3 0 0 3 3 3 0 GRB2-binding adapter (GAPT) UvrD-helicase PF00580.21 KOG99285.1 - 0.34 10.4 0.0 0.34 10.4 0.0 3.3 3 1 0 3 3 3 0 UvrD/REP helicase N-terminal domain DUF2420 PF10336.9 KOG99286.1 - 2.6e-38 130.4 0.9 4.7e-38 129.5 0.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) RNase_P_p30 PF01876.16 KOG99287.1 - 0.02 14.4 1.0 0.066 12.7 0.1 2.2 2 0 0 2 2 2 0 RNase P subunit p30 PDEase_II PF02112.15 KOG99288.1 - 3e-115 385.0 0.1 3.6e-115 384.7 0.1 1.0 1 0 0 1 1 1 1 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 KOG99288.1 - 0.0047 16.5 0.1 0.008 15.7 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Herpes_ICP4_N PF03584.15 KOG99288.1 - 0.17 11.7 0.0 0.45 10.3 0.0 1.6 1 1 0 1 1 1 0 Herpesvirus ICP4-like protein N-terminal region Brr6_like_C_C PF10104.9 KOG99289.1 - 3.3e-43 146.6 0.6 4e-43 146.4 0.6 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Baculo_11_kDa PF06143.11 KOG99289.1 - 0.015 14.9 0.3 0.015 14.9 0.3 1.9 2 0 0 2 2 2 0 Baculovirus 11 kDa family RAI1 PF08652.11 KOG99290.1 - 8.9e-27 93.1 0.4 1.7e-26 92.1 0.4 1.5 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease tRNA-synt_1c PF00749.21 KOG99291.1 - 8.8e-123 409.2 0.1 1.2e-122 408.8 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 KOG99291.1 - 1.5e-39 135.6 1.9 3.5e-39 134.4 0.8 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain GluRS_N PF18466.1 KOG99291.1 - 3.9e-09 36.8 2.2 1.4e-08 35.0 2.2 2.1 1 0 0 1 1 1 1 Glutamate--tRNA ligase N-terminal domain GST_C_2 PF13410.6 KOG99291.1 - 0.032 14.3 0.0 0.094 12.7 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain tRNA-synt_1e PF01406.19 KOG99291.1 - 0.074 12.4 0.1 0.16 11.3 0.1 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain GST_C PF00043.25 KOG99291.1 - 0.13 12.5 0.1 0.59 10.4 0.0 2.2 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Plus-3 PF03126.18 KOG99292.1 - 5.1e-29 101.0 1.3 5.3e-28 97.7 0.0 2.7 2 0 0 2 2 2 1 Plus-3 domain A_deamin PF02137.18 KOG99293.1 - 4.5e-25 88.8 0.0 5.7e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain Ank PF00023.30 KOG99294.1 - 4.9e-09 36.2 0.1 0.0052 17.2 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KOG99294.1 - 5.2e-07 29.5 0.0 0.0016 18.8 0.0 3.5 3 1 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 KOG99294.1 - 9.5e-07 29.3 0.0 2.3e-06 28.1 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOG99294.1 - 6.5e-06 26.3 0.1 0.0085 16.4 0.0 3.9 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOG99294.1 - 0.0001 22.8 0.7 0.017 15.7 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) PucR PF07905.11 KOG99294.1 - 0.075 13.3 0.0 5.3 7.3 0.0 2.6 2 1 1 3 3 3 0 Purine catabolism regulatory protein-like family YjzC PF14168.6 KOG99294.1 - 0.11 12.9 0.1 0.2 12.0 0.1 1.4 1 0 0 1 1 1 0 YjzC-like protein IBN_N PF03810.19 KOG99295.1 - 2.1e-10 40.4 1.9 5.6e-10 39.0 0.4 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain ANAPC10 PF03256.16 KOG99296.1 - 1e-36 126.3 0.0 1.4e-36 125.9 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 KOG99296.1 - 0.088 12.9 0.0 0.26 11.4 0.0 1.7 2 0 0 2 2 2 0 F5/8 type C domain Cse1 PF08506.10 KOG99297.1 - 9e-176 584.1 12.3 1.6e-175 583.3 12.3 1.4 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 KOG99297.1 - 3.7e-109 365.2 13.0 3.7e-109 365.2 13.0 1.8 3 0 0 3 3 3 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 KOG99297.1 - 4.8e-20 71.3 0.3 2.4e-18 65.8 0.0 3.6 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.12 KOG99297.1 - 0.0039 17.3 3.2 0.012 15.7 0.1 3.7 3 1 0 3 3 3 1 Exportin 1-like protein CBFB_NFYA PF02045.15 KOG99298.1 - 1.4e-27 96.0 9.0 3.9e-27 94.6 9.0 1.8 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B DUF2633 PF11119.8 KOG99298.1 - 2.2 8.3 7.1 8.4 6.4 7.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2633) GIDA PF01134.22 KOG99299.1 - 8.8e-159 528.8 0.0 1.2e-158 528.4 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 KOG99299.1 - 1.2e-65 221.7 0.0 1.7e-65 221.1 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain Pyr_redox_2 PF07992.14 KOG99299.1 - 1.2e-07 31.3 0.5 7e-07 28.8 0.5 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KOG99299.1 - 2.5e-05 23.8 0.5 3.9e-05 23.2 0.5 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOG99299.1 - 0.00054 20.5 0.3 0.0021 18.6 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOG99299.1 - 0.0017 17.7 0.0 0.0052 16.1 0.0 1.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOG99299.1 - 0.0017 17.7 0.1 0.0036 16.6 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 KOG99299.1 - 0.002 17.2 0.2 0.013 14.5 0.2 2.1 1 1 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 KOG99299.1 - 0.0079 15.3 3.7 0.02 14.0 2.6 1.9 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 KOG99299.1 - 0.022 13.5 1.5 0.17 10.5 0.7 2.1 2 0 0 2 2 2 0 HI0933-like protein DAO PF01266.24 KOG99299.1 - 0.028 14.0 0.9 2.3 7.7 0.7 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 KOG99299.1 - 0.065 13.2 0.6 0.12 12.4 0.0 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 KOG99299.1 - 0.088 13.1 0.8 0.24 11.7 0.8 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 KOG99299.1 - 0.14 12.6 0.0 0.43 11.0 0.1 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding GARS_A PF01071.19 KOG99300.1 - 2.1e-81 272.4 0.0 3.9e-81 271.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain AIRS_C PF02769.22 KOG99300.1 - 1.3e-33 116.3 0.0 2.8e-33 115.3 0.0 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.15 KOG99300.1 - 8.1e-32 109.9 0.0 3.7e-31 107.8 0.0 2.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 KOG99300.1 - 1.5e-27 95.7 0.7 3.6e-27 94.5 0.7 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 KOG99300.1 - 1.8e-15 57.3 1.3 7.4e-15 55.4 1.3 2.1 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ATP-grasp_3 PF02655.14 KOG99300.1 - 0.065 13.3 0.2 0.21 11.6 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain ATP-grasp_4 PF13535.6 KOG99300.1 - 0.072 12.7 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Sec15 PF04091.12 KOG99301.1 - 9.9e-105 350.4 3.4 9.9e-105 350.4 3.4 1.9 2 0 0 2 2 2 1 Exocyst complex subunit Sec15-like DUF1077 PF06417.12 KOG99302.1 - 2.8e-42 143.5 4.7 3.5e-42 143.1 4.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) DUF2207 PF09972.9 KOG99303.1 - 0.017 13.9 1.6 0.022 13.6 1.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SAPS PF04499.15 KOG99304.1 - 1.1e-152 509.2 8.2 1.9e-152 508.5 8.2 1.4 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Gp-FAR-1 PF05823.12 KOG99305.1 - 0.0056 17.0 1.7 0.0056 17.0 1.7 2.6 3 0 0 3 3 3 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) SPRY PF00622.28 KOG99306.1 - 8.4e-38 129.2 0.2 2e-37 127.9 0.2 1.7 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.9 KOG99306.1 - 9.1e-12 45.1 3.7 2.5e-11 43.7 4.0 1.6 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 KOG99306.1 - 0.0018 18.1 0.0 0.0064 16.4 0.0 2.0 1 0 0 1 1 1 1 LisH BUD22 PF09073.10 KOG99306.1 - 1.6 8.0 26.5 0.026 13.9 15.1 2.3 2 0 0 2 2 2 0 BUD22 CNDH2_C PF16858.5 KOG99306.1 - 3.4 7.5 13.3 7.9 6.3 7.5 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term COX4 PF02936.14 KOG99307.1 - 4.6e-07 29.9 0.0 5.7e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV SRP1_TIP1 PF00660.17 KOG99309.1 - 2.1e-26 91.9 0.0 2.8e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 Seripauperin and TIP1 family EamA PF00892.20 KOG99310.1 - 2.1e-09 37.7 31.7 4.7e-05 23.6 9.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 KOG99310.1 - 1.4 8.2 21.0 4.1 6.7 21.0 1.6 1 1 0 1 1 1 0 Triose-phosphate Transporter family HAD_2 PF13419.6 KOG99311.1 - 4.2e-07 30.2 0.0 1e-06 29.0 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOG99311.1 - 1.3e-06 28.9 0.0 0.00012 22.5 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 KOG99311.1 - 0.0079 16.1 0.0 0.19 11.6 0.0 2.4 2 1 0 2 2 2 1 Acid Phosphatase Vps51 PF08700.11 KOG99312.1 - 0.0023 18.0 3.9 0.0052 16.8 0.3 3.2 4 0 0 4 4 4 1 Vps51/Vps67 SOGA PF11365.8 KOG99312.1 - 0.058 14.5 0.3 11 7.3 0.1 2.6 2 0 0 2 2 2 0 Protein SOGA Spore_GerQ PF09671.10 KOG99312.1 - 0.13 12.2 1.0 0.21 11.6 0.2 1.8 2 0 0 2 2 2 0 Spore coat protein (Spore_GerQ) KLRAQ PF10205.9 KOG99312.1 - 5.5 7.3 6.4 1.5 9.1 1.6 2.5 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein PNRC PF15365.6 KOG99313.1 - 2.9e-05 23.7 0.3 2.9e-05 23.7 0.3 3.9 3 1 0 3 3 2 1 Proline-rich nuclear receptor coactivator motif SRP-alpha_N PF04086.13 KOG99313.1 - 0.16 11.8 10.1 0.22 11.4 10.1 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CCDC24 PF15669.5 KOG99313.1 - 0.16 11.8 7.2 0.25 11.2 7.2 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family SPX PF03105.19 KOG99313.1 - 0.59 10.0 16.5 0.67 9.8 16.5 1.1 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 KOG99313.1 - 0.92 8.0 14.4 1 7.8 14.4 1.0 1 0 0 1 1 1 0 Macoilin family SR-25 PF10500.9 KOG99313.1 - 1.4 8.5 30.4 2.9 7.4 30.4 1.6 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4698 PF15769.5 KOG99313.1 - 2.9 6.9 6.7 3.9 6.4 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Peroxin-3 PF04882.12 KOG99313.1 - 3.4 6.6 10.4 4.2 6.2 10.4 1.1 1 0 0 1 1 1 0 Peroxin-3 Ndc1_Nup PF09531.10 KOG99313.1 - 4.2 5.9 12.1 4.8 5.8 12.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GREB1 PF15782.5 KOG99313.1 - 5.2 4.0 8.8 5.7 3.9 8.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Apt1 PF10351.9 KOG99313.1 - 6.2 5.5 13.7 7.6 5.3 13.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain NIF3 PF01784.18 KOG99314.1 - 3.4e-65 220.1 0.0 4.1e-65 219.8 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) tRNA-synt_1c_C PF03950.18 KOG99315.1 - 0.068 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), anti-codon binding domain Kinesin PF00225.23 KOG99316.1 - 1e-114 383.0 1.5 1e-114 383.0 1.5 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOG99316.1 - 4.2e-28 98.2 0.1 1.8e-27 96.1 0.1 2.1 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 KOG99316.1 - 0.082 13.3 0.0 0.44 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Cyclin PF08613.11 KOG99317.1 - 9.8e-05 22.8 0.1 0.0002 21.8 0.1 1.5 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 KOG99317.1 - 0.039 13.7 0.0 0.11 12.2 0.0 1.8 1 1 0 1 1 1 0 Cyclin, N-terminal domain WD40 PF00400.32 KOG99318.1 - 5.7e-12 45.9 17.0 4.1e-06 27.4 2.8 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG99318.1 - 2.4e-09 37.4 0.0 0.0033 17.7 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOG99318.1 - 0.009 15.0 0.0 0.45 9.4 0.0 3.0 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KOG99318.1 - 0.016 15.1 0.0 7 6.5 0.0 2.3 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.6 KOG99318.1 - 0.073 13.1 0.0 6.3 6.9 0.0 2.7 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region PX PF00787.24 KOG99319.1 - 2.7e-14 53.1 0.5 7e-14 51.8 0.1 1.8 2 0 0 2 2 2 1 PX domain GrpE PF01025.19 KOG99319.1 - 4.1 7.0 7.3 9.5 5.9 2.0 2.3 2 0 0 2 2 2 0 GrpE ATP_bind_3 PF01171.20 KOG99320.1 - 3.3e-17 62.8 0.0 7e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 KOG99320.1 - 2.4e-16 58.9 4.9 2.4e-16 58.9 4.9 3.3 3 1 1 4 4 4 1 Zinc-ribbon tRNA_Me_trans PF03054.16 KOG99320.1 - 0.018 13.8 0.0 0.037 12.8 0.0 1.5 1 1 0 1 1 1 0 tRNA methyl transferase CTU2 PF10288.9 KOG99320.1 - 0.024 14.9 0.2 0.024 14.9 0.2 2.4 3 1 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 PAPS_reduct PF01507.19 KOG99320.1 - 0.075 13.1 0.0 0.34 10.9 0.0 2.0 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family Cytochrom_c3_2 PF14537.6 KOG99320.1 - 2.7 8.5 6.1 17 5.9 1.1 2.5 2 0 0 2 2 2 0 Cytochrome c3 Ras PF00071.22 KOG99321.1 - 1.2e-59 200.5 0.3 1.4e-59 200.3 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG99321.1 - 1.3e-34 119.0 0.1 1.9e-34 118.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG99321.1 - 4e-13 49.2 0.0 5.4e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOG99321.1 - 5e-07 29.8 0.1 7.8e-07 29.2 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOG99321.1 - 6.2e-05 22.6 0.2 0.00016 21.3 0.2 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain KAP_NTPase PF07693.14 KOG99321.1 - 0.0012 18.2 0.0 0.0018 17.6 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain Gtr1_RagA PF04670.12 KOG99321.1 - 0.0013 18.2 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KOG99321.1 - 0.0014 18.6 0.0 0.0091 15.9 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 KOG99321.1 - 0.0025 17.3 0.0 0.0036 16.7 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 KOG99321.1 - 0.017 15.5 0.0 0.026 14.9 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 KOG99321.1 - 0.032 13.8 0.0 0.055 13.0 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_22 PF13401.6 KOG99321.1 - 0.032 14.5 0.0 0.096 13.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOG99321.1 - 0.036 14.6 0.2 0.052 14.1 0.2 1.4 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 KOG99321.1 - 0.046 13.4 0.1 0.087 12.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 KOG99321.1 - 0.075 12.3 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Septin PduV-EutP PF10662.9 KOG99321.1 - 0.085 12.6 0.0 0.19 11.4 0.0 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 KOG99321.1 - 0.1 12.1 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region MCM PF00493.23 KOG99321.1 - 0.12 11.4 0.1 0.27 10.3 0.0 1.5 1 1 0 1 1 1 0 MCM P-loop domain AAA_21 PF13304.6 KOG99321.1 - 0.14 11.9 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system zf-C2H2 PF00096.26 KOG99322.1 - 1.2e-08 35.0 18.7 4.1e-06 27.0 3.7 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOG99322.1 - 1e-07 32.0 19.6 0.00045 20.5 7.0 3.4 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOG99322.1 - 1.5e-05 25.4 14.9 0.0016 19.1 2.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOG99322.1 - 0.00082 19.6 4.3 0.083 13.2 0.5 2.9 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 KOG99322.1 - 0.032 14.0 0.6 0.032 14.0 0.6 3.3 4 0 0 4 4 4 0 C2H2-type zinc-finger domain FOXP-CC PF16159.5 KOG99322.1 - 0.094 13.4 0.2 0.094 13.4 0.2 2.4 2 0 0 2 2 2 0 FOXP coiled-coil domain TFIIA PF03153.13 KOG99322.1 - 0.25 11.3 23.8 0.37 10.7 23.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RPAP2_Rtr1 PF04181.13 KOG99322.1 - 0.36 11.2 3.3 1.4 9.3 0.1 2.5 2 0 0 2 2 2 0 Rtr1/RPAP2 family zf-C2HE PF16278.5 KOG99322.1 - 0.37 11.3 5.5 0.87 10.1 0.7 2.9 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 KOG99322.1 - 2.2 8.4 20.2 0.15 12.1 0.5 3.6 3 1 0 3 3 3 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 KOG99322.1 - 4.3 7.4 7.9 2.5 8.1 0.3 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type AMPK1_CBM PF16561.5 KOG99323.1 - 4.5e-29 100.5 0.0 9.3e-29 99.5 0.0 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 KOG99323.1 - 2e-27 95.2 3.1 2e-27 95.2 3.1 2.0 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain IMUP PF15761.5 KOG99323.1 - 0.058 14.1 3.8 0.12 13.1 3.8 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein FACT-Spt16_Nlob PF14826.6 KOG99324.1 - 1.1e-48 165.1 0.3 1.1e-48 165.1 0.3 3.0 3 0 0 3 3 3 1 FACT complex subunit SPT16 N-terminal lobe domain SPT16 PF08644.11 KOG99324.1 - 1.1e-48 165.2 0.2 1.1e-48 165.2 0.2 2.2 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.24 KOG99324.1 - 1e-30 107.0 0.0 1.8e-30 106.2 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 KOG99324.1 - 3.5e-13 49.8 0.2 1.5e-12 47.7 0.1 2.2 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Clathrin PF00637.20 KOG99325.1 - 6.5e-196 642.1 54.8 1e-33 116.2 0.2 8.2 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 KOG99325.1 - 4.5e-26 90.5 1.8 1.1e-25 89.3 0.3 2.4 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.20 KOG99325.1 - 3.4e-25 87.1 5.7 4e-06 26.9 0.3 5.8 5 0 0 5 5 5 5 Clathrin propeller repeat Clathrin-link PF09268.10 KOG99325.1 - 6.3e-08 31.8 0.4 6.3e-08 31.8 0.4 3.1 3 0 0 3 3 3 1 Clathrin, heavy-chain linker TPR_7 PF13176.6 KOG99325.1 - 0.0032 17.4 2.8 21 5.4 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOG99325.1 - 0.32 11.3 3.0 4.8 7.6 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOG99325.1 - 0.85 10.0 6.9 1.9 8.9 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat ACOX PF01756.19 KOG99326.1 - 1.9e-43 148.2 0.0 3.8e-43 147.2 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 KOG99326.1 - 1e-22 80.1 0.0 2.2e-22 79.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 KOG99326.1 - 2.8e-10 40.8 0.0 1.5e-09 38.5 0.0 2.1 1 1 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 KOG99326.1 - 0.00075 19.7 0.0 0.011 15.9 0.0 2.3 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Peptidase_S10 PF00450.22 KOG99327.1 - 4e-111 372.4 0.1 7e-111 371.6 0.1 1.3 1 0 0 1 1 1 1 Serine carboxypeptidase SARAF PF06682.12 KOG99327.1 - 0.12 12.0 5.1 0.95 9.1 0.1 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Aminotran_1_2 PF00155.21 KOG99328.1 - 1.2e-18 67.4 0.0 1.7e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 KOG99328.1 - 0.18 11.1 0.2 0.62 9.3 0.0 1.7 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family MCM PF00493.23 KOG99329.1 - 6.4e-103 342.7 0.4 1e-102 342.0 0.4 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KOG99329.1 - 2.2e-40 137.4 0.1 9.5e-40 135.4 0.0 2.0 2 0 0 2 2 2 1 MCM OB domain MCM6_C PF18263.1 KOG99329.1 - 4.4e-31 107.3 1.7 1.1e-30 106.0 1.7 1.7 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_N PF14551.6 KOG99329.1 - 1.7e-26 92.8 0.3 7.5e-26 90.7 0.1 2.3 2 0 0 2 2 2 1 MCM N-terminal domain MCM_lid PF17855.1 KOG99329.1 - 2e-26 92.2 0.8 5.5e-26 90.8 0.8 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 KOG99329.1 - 2.4e-07 30.4 0.0 7.8e-07 28.7 0.0 1.9 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 KOG99329.1 - 0.0038 17.0 0.0 0.0079 15.9 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 KOG99329.1 - 0.009 15.9 0.1 0.031 14.1 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOG99329.1 - 0.061 13.3 0.0 0.15 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) GIDA_assoc PF13932.6 KOG99329.1 - 0.069 13.3 1.1 0.2 11.8 0.1 2.2 2 0 0 2 2 2 0 GidA associated domain RRN3 PF05327.11 KOG99329.1 - 7.9 4.9 8.3 0.21 10.1 1.5 1.8 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 EMP24_GP25L PF01105.24 KOG99330.1 - 2.3e-44 151.5 0.1 2.6e-44 151.3 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Lsr2 PF11774.8 KOG99330.1 - 0.0062 16.7 0.1 0.0099 16.0 0.1 1.2 1 0 0 1 1 1 1 Lsr2 Yip1 PF04893.17 KOG99331.1 - 1.1e-12 48.0 11.5 1.5e-12 47.6 11.5 1.2 1 0 0 1 1 1 1 Yip1 domain Kelch_6 PF13964.6 KOG99332.1 - 2.6e-15 56.1 2.2 1.9e-08 34.3 0.0 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 KOG99332.1 - 1.9e-14 53.4 5.7 1.4e-05 25.0 0.0 5.6 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KOG99332.1 - 1.1e-13 50.5 0.7 4.5e-05 22.9 0.0 4.1 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 KOG99332.1 - 3.4e-09 36.3 0.5 8.2e-06 25.6 0.0 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 KOG99332.1 - 8.5e-09 35.5 1.1 0.00016 21.9 0.0 5.4 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_5 PF13854.6 KOG99332.1 - 4e-06 26.7 0.2 0.0034 17.3 0.0 3.7 3 0 0 3 3 3 1 Kelch motif D-ser_dehydrat PF14031.6 KOG99333.1 - 1.7e-18 67.1 0.0 3.4e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 KOG99333.1 - 2.5e-11 43.7 0.0 4.9e-11 42.7 0.0 1.4 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain HEAT PF02985.22 KOG99334.1 - 5.7e-28 94.6 25.3 0.0043 17.2 0.0 19.0 24 0 0 24 24 22 6 HEAT repeat HEAT_EZ PF13513.6 KOG99334.1 - 1.9e-27 95.3 19.2 0.00023 21.6 0.0 15.5 15 3 3 18 18 17 6 HEAT-like repeat Gcn1_N PF12074.8 KOG99334.1 - 1.5e-26 93.6 1.8 2.7e-13 49.9 0.0 3.9 3 0 0 3 3 3 2 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT_2 PF13646.6 KOG99334.1 - 1.7e-24 86.0 17.3 7.5e-05 23.1 0.2 12.1 7 2 7 14 14 14 6 HEAT repeats CLASP_N PF12348.8 KOG99334.1 - 3.1e-15 56.4 7.2 0.0035 16.9 0.0 9.8 9 2 1 11 11 11 3 CLASP N terminal Cnd1 PF12717.7 KOG99334.1 - 2.5e-13 50.4 16.0 0.081 13.0 0.0 11.6 9 2 4 13 13 13 5 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KOG99334.1 - 3.8e-12 46.6 2.3 0.073 13.7 0.0 9.2 9 2 2 11 11 11 2 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 KOG99334.1 - 0.00087 19.2 5.3 47 3.9 0.3 8.3 7 2 1 8 8 8 0 Domain of unknown function (DUF3385) DUF3535 PF12054.8 KOG99334.1 - 0.0096 15.2 0.8 0.93 8.7 0.0 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF3535) SbsC_C PF18058.1 KOG99334.1 - 0.18 12.0 1.5 0.5 10.6 1.5 1.7 1 0 0 1 1 1 0 SbsC C-terminal domain GerD PF17898.1 KOG99334.1 - 0.19 11.7 1.8 1.2 9.2 1.8 2.5 1 0 0 1 1 1 0 Spore germination GerD central core domain RTP1_C1 PF10363.9 KOG99334.1 - 0.76 10.0 4.2 3e+02 1.6 0.0 6.7 7 1 0 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 Hist_deacetyl PF00850.19 KOG99336.1 - 2.3e-83 280.2 0.0 2.9e-83 279.9 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain MT-A70 PF05063.14 KOG99337.1 - 1.5e-57 194.3 0.2 1.5e-57 194.3 0.2 1.8 2 0 0 2 2 2 1 MT-A70 COX6A PF02046.15 KOG99338.1 - 1.5e-37 128.5 0.2 1.7e-37 128.3 0.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa WD40 PF00400.32 KOG99339.1 - 6.2e-15 55.3 0.2 0.0042 17.9 0.0 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG99339.1 - 0.0001 22.6 0.1 21 5.5 0.0 5.0 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Macoilin PF09726.9 KOG99339.1 - 4.9 5.6 17.6 0.33 9.5 12.5 1.5 2 0 0 2 2 2 0 Macoilin family Ribosomal_S26e PF01283.19 KOG99340.1 - 6.7e-51 171.3 10.2 7.8e-51 171.0 10.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e COX5B PF01215.19 KOG99341.1 - 5.2e-65 217.0 0.0 6.2e-65 216.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb Transp_cyt_pur PF02133.15 KOG99342.1 - 3.9e-17 62.2 35.4 3.9e-17 62.2 35.4 2.0 2 0 0 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin 2-Hacid_dh_C PF02826.19 KOG99343.1 - 1.1e-30 106.3 0.0 1.7e-30 105.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOG99343.1 - 1.7e-05 24.5 0.0 3.2e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KOG99343.1 - 0.0012 19.1 0.0 0.002 18.3 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 KOG99343.1 - 0.0076 15.9 0.0 0.017 14.8 0.0 1.7 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Cys_Met_Meta_PP PF01053.20 KOG99344.1 - 3.1e-130 434.1 0.0 3.6e-130 433.9 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Mnd1 PF03962.15 KOG99345.1 - 3e-12 46.6 0.8 3e-12 46.6 0.8 2.5 2 0 0 2 2 2 1 Mnd1 HTH domain LZ3wCH PF18517.1 KOG99345.1 - 1.1e-05 25.4 2.8 1.1e-05 25.4 2.8 2.3 2 0 0 2 2 2 1 Leucine zipper with capping helix domain CHASE3 PF05227.13 KOG99345.1 - 0.006 16.5 1.9 0.006 16.5 1.9 1.5 1 1 0 1 1 1 1 CHASE3 domain DUF2684 PF10885.8 KOG99345.1 - 0.04 14.0 0.0 12 6.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2684) RL11D PF11088.8 KOG99345.1 - 0.082 13.2 0.4 0.21 11.9 0.1 1.8 2 1 0 2 2 2 0 Glycoprotein encoding membrane proteins RL5A and RL6 DUF4407 PF14362.6 KOG99345.1 - 0.098 12.0 2.9 0.11 11.8 2.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Img2 PF05046.14 KOG99345.1 - 0.36 11.2 3.3 1.2 9.5 3.3 2.0 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) PRKG1_interact PF15898.5 KOG99345.1 - 0.51 11.3 9.0 0.35 11.8 6.8 1.8 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain KxDL PF10241.9 KOG99345.1 - 4.8 7.5 15.4 3 8.2 0.9 3.0 2 1 0 2 2 2 0 Uncharacterized conserved protein ArfGap PF01412.18 KOG99346.1 - 9.1e-29 99.9 0.0 9.1e-29 99.9 0.0 2.9 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf UBA PF00627.31 KOG99346.1 - 1e-08 34.9 0.0 1e-08 34.9 0.0 2.3 3 0 0 3 3 3 1 UBA/TS-N domain Med15 PF09606.10 KOG99346.1 - 8e-05 21.6 61.3 0.00013 20.9 61.3 1.3 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 KOG99346.1 - 0.064 13.2 51.5 0.099 12.6 51.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 KOG99346.1 - 0.068 10.3 14.8 0.077 10.1 14.8 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Cellulose_synt PF03552.14 KOG99346.1 - 3 6.2 4.4 3.9 5.9 4.4 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF3543 PF12063.8 KOG99347.1 - 2.1e-85 286.1 8.0 4.1e-85 285.2 8.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 KOG99347.1 - 4.2e-59 200.1 0.0 1.1e-58 198.7 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99347.1 - 6.1e-45 153.5 0.0 1.1e-44 152.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG99347.1 - 0.05 12.9 0.0 1.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Pkinase PF00069.25 KOG99348.1 - 4.6e-63 213.0 0.0 6e-63 212.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99348.1 - 2.1e-33 115.7 0.0 3.3e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG99348.1 - 2.1e-08 33.9 0.0 5.5e-08 32.5 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOG99348.1 - 2.6e-05 23.2 0.0 3.8e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 KOG99348.1 - 0.043 12.9 0.0 0.18 10.8 0.0 1.9 2 0 0 2 2 2 0 Seadornavirus VP7 Kdo PF06293.14 KOG99348.1 - 0.1 11.9 0.0 1.1 8.6 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PUF PF00806.19 KOG99349.1 - 2e-58 190.9 31.5 2.7e-08 33.0 0.2 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Miff PF05644.11 KOG99349.1 - 0.95 9.0 8.6 1.9 8.0 8.6 1.4 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Lectin_C_term PF18022.1 KOG99350.1 - 0.044 14.3 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin C-terminal domain DUF4588 PF15251.6 KOG99351.1 - 0.041 13.6 5.1 0.074 12.8 5.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) SAE2 PF08573.10 KOG99351.1 - 3.5 8.8 0.0 3.5 8.8 0.0 3.1 3 1 0 3 3 3 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Bud13 PF09736.9 KOG99352.1 - 1.5e-21 77.3 10.4 5.3e-20 72.3 5.2 3.0 2 1 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex TOM20_plant PF06552.12 KOG99352.1 - 0.94 9.2 6.0 1.3 8.8 0.1 3.3 2 1 2 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 XRN_N PF03159.18 KOG99353.1 - 2.8e-96 321.6 0.2 2.8e-96 321.6 0.2 2.0 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 KOG99353.1 - 3e-85 286.8 7.9 3e-85 286.8 7.9 3.2 4 0 0 4 4 4 1 Xrn1 helical domain XRN1_D1 PF18332.1 KOG99353.1 - 9.8e-66 221.2 4.0 1.1e-65 221.0 0.0 2.8 2 1 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 KOG99353.1 - 1.1e-31 108.9 0.2 8.9e-31 106.0 0.1 2.6 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D2/D3 domain Xrn1_D3 PF18194.1 KOG99353.1 - 7.8e-24 83.6 0.1 3.4e-23 81.5 0.1 2.2 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 SH3_12 PF18129.1 KOG99353.1 - 6.1e-20 71.1 0.1 1.1e-19 70.3 0.1 1.4 1 0 0 1 1 1 1 Xrn1 SH3-like domain DUF5633 PF18656.1 KOG99353.1 - 0.27 11.2 0.0 0.27 11.2 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5633) Nucleoporin_FG PF13634.6 KOG99354.1 - 3.4e-20 72.7 108.9 7.1e-09 36.4 24.1 4.9 2 1 3 5 5 5 4 Nucleoporin FG repeat region Fibin PF15819.5 KOG99354.1 - 0.029 14.1 1.6 0.078 12.7 1.2 1.7 1 1 1 2 2 2 0 Fin bud initiation factor homologue DUF1664 PF07889.12 KOG99354.1 - 0.03 14.3 1.0 2 8.4 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 KOG99354.1 - 0.068 13.6 4.6 3.3 8.3 0.0 2.6 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DEAD PF00270.29 KOG99355.1 - 4.3e-43 147.1 0.4 1.3e-42 145.5 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG99355.1 - 6.9e-32 110.1 0.7 3.3e-27 95.0 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 KOG99355.1 - 1.1e-05 25.5 0.0 1.1e-05 25.5 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOG99355.1 - 0.29 11.4 1.9 5.9 7.2 1.9 2.6 1 1 0 1 1 1 0 AAA domain P68HR PF08061.11 KOG99356.1 - 0.011 15.9 3.1 0.014 15.5 1.2 2.2 2 0 0 2 2 2 0 P68HR (NUC004) repeat Sua5_yciO_yrdC PF01300.18 KOG99357.1 - 1.2e-46 158.5 0.0 3.1e-46 157.1 0.0 1.7 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 KOG99357.1 - 1.2e-31 110.1 0.0 1.8e-31 109.5 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding E1-E2_ATPase PF00122.20 KOG99358.1 - 7.8e-48 162.4 0.2 7.8e-48 162.4 0.2 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 KOG99358.1 - 8.3e-47 159.2 1.2 8.3e-47 159.2 1.2 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 KOG99358.1 - 7e-20 72.2 0.0 2e-19 70.7 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOG99358.1 - 8e-18 64.3 0.0 1.7e-17 63.2 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KOG99358.1 - 3.8e-16 58.5 0.0 9.1e-16 57.3 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOG99358.1 - 0.00015 21.6 0.3 0.012 15.4 0.3 2.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3784 PF12650.7 KOG99358.1 - 0.029 14.6 2.1 1.7 8.9 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3784) Copper-fist PF00649.18 KOG99359.1 - 6.2e-21 73.6 2.1 6.2e-21 73.6 2.1 2.0 1 1 1 2 2 2 1 Copper fist DNA binding domain Ran-binding PF05508.11 KOG99360.1 - 1.4e-113 379.0 6.2 1.4e-113 379.0 6.2 1.5 2 0 0 2 2 2 1 RanGTP-binding protein TRAP-gamma PF07074.12 KOG99360.1 - 0.02 14.5 1.2 0.039 13.5 0.1 2.0 1 1 1 2 2 2 0 Translocon-associated protein, gamma subunit (TRAP-gamma) CobT PF06213.12 KOG99360.1 - 0.17 11.3 16.0 0.47 9.8 16.0 1.8 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF913 PF06025.12 KOG99360.1 - 1.1 8.2 6.9 0.76 8.7 3.8 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Laminin_II PF06009.12 KOG99360.1 - 1.3 9.1 8.1 0.085 12.9 0.6 2.8 3 0 0 3 3 3 0 Laminin Domain II CPSF100_C PF13299.6 KOG99360.1 - 1.8 8.7 9.6 0.085 13.0 3.1 2.1 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 KOG99360.1 - 5.8 6.6 6.2 0.9 9.2 1.4 2.0 3 0 0 3 3 3 0 Connexin DNA_pol_phi PF04931.13 KOG99360.1 - 9.6 4.2 29.6 3.3 5.7 26.3 1.8 2 0 0 2 2 2 0 DNA polymerase phi SNF2_N PF00176.23 KOG99361.1 - 5e-56 189.9 0.0 7.7e-56 189.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 KOG99361.1 - 1.3e-49 168.8 1.1 6.1e-49 166.6 1.1 2.1 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.31 KOG99361.1 - 1.7e-16 60.5 0.0 4.1e-16 59.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG99361.1 - 7.2e-08 32.6 0.3 2.3e-07 31.0 0.0 2.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KOG99361.1 - 6.7e-06 25.5 2.1 2.6e-05 23.5 0.1 2.7 2 2 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 Zn_clus PF00172.18 KOG99363.1 - 0.0012 18.9 3.6 0.0012 18.9 3.6 3.0 3 0 0 3 3 3 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Yip1 PF04893.17 KOG99364.1 - 1.9e-07 30.9 0.3 3.7e-07 30.0 0.2 1.6 1 1 0 1 1 1 1 Yip1 domain DUF2427 PF10348.9 KOG99364.1 - 0.00013 21.7 0.3 0.00032 20.4 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF2427) IBD PF10416.9 KOG99364.1 - 0.035 14.1 0.0 0.074 13.1 0.0 1.5 1 0 0 1 1 1 0 Transcription-initiator DNA-binding domain IBD Ferric_reduct PF01794.19 KOG99365.1 - 7.5e-22 77.8 10.4 7.5e-22 77.8 10.4 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 KOG99365.1 - 2.4e-20 73.3 0.0 3.6e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 KOG99365.1 - 1.1e-15 57.6 0.1 3.8e-15 55.9 0.1 1.8 2 0 0 2 2 2 1 FAD-binding domain OCD_Mu_crystall PF02423.15 KOG99366.1 - 1.4e-08 34.0 0.0 7.4e-07 28.4 0.0 2.4 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Pkinase PF00069.25 KOG99367.1 - 1.9e-58 197.9 0.0 3.5e-58 197.1 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99367.1 - 2.7e-24 85.9 0.0 3.4e-23 82.2 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG99367.1 - 3.8e-06 26.4 0.2 5.9e-05 22.5 0.1 2.4 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 KOG99367.1 - 0.0001 21.7 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KOG99367.1 - 0.15 11.7 0.0 6.2 6.4 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 IL17R_fnIII_D2 PF16578.5 KOG99367.1 - 1.7 9.2 3.8 3 8.4 0.1 3.0 4 0 0 4 4 4 0 Interleukin 17 receptor D Epimerase PF01370.21 KOG99368.1 - 2.9e-13 49.9 0.0 5e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOG99368.1 - 5e-11 42.1 0.0 6.8e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 KOG99368.1 - 9.6e-09 34.8 0.4 1.9e-05 23.9 0.1 2.1 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 KOG99368.1 - 3.7e-08 33.1 0.1 6.6e-08 32.3 0.0 1.4 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 KOG99368.1 - 1.1e-05 25.5 0.0 1.6e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 KOG99368.1 - 2.4e-05 24.3 0.0 4.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 KOG99368.1 - 3.8e-05 23.2 0.2 0.0013 18.3 0.1 2.5 2 1 0 2 2 2 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 KOG99368.1 - 0.00027 20.2 0.2 0.00059 19.1 0.1 1.5 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.13 KOG99368.1 - 0.027 14.0 0.0 0.13 11.8 0.1 2.0 2 0 0 2 2 2 0 NmrA-like family Glyco_hydro_38N PF01074.22 KOG99369.1 - 2.2e-85 286.5 0.4 3.5e-85 285.9 0.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 KOG99369.1 - 4.6e-56 190.3 0.5 9.7e-56 189.2 0.1 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 KOG99369.1 - 1.5e-26 92.4 0.0 3.1e-26 91.4 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 KOG99369.1 - 7.6e-09 35.6 0.2 3e-08 33.6 0.2 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Prenyltrans PF00432.21 KOG99370.1 - 3.2e-33 113.1 5.1 8.3e-08 31.8 0.0 4.6 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat U3_assoc_6 PF08640.11 KOG99370.1 - 0.087 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 6 DUF5098 PF17023.5 KOG99370.1 - 0.11 11.4 0.2 0.15 11.0 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5098) ACPS PF01648.20 KOG99371.1 - 6.5e-10 39.2 0.0 1.3e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Pex14_N PF04695.13 KOG99372.1 - 2.9e-25 89.7 5.6 2.9e-25 89.7 5.6 3.4 3 1 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region zf-C4H2 PF10146.9 KOG99372.1 - 0.00076 19.9 9.8 0.0015 18.9 9.8 1.5 1 0 0 1 1 1 1 Zinc finger-containing protein Nsp1_C PF05064.13 KOG99372.1 - 0.0021 17.9 13.9 0.23 11.3 4.4 3.2 1 1 2 3 3 3 2 Nsp1-like C-terminal region DUF1216 PF06746.11 KOG99372.1 - 0.0037 17.3 0.2 0.0037 17.3 0.2 2.2 2 1 1 3 3 2 1 Protein of unknown function (DUF1216) Mating_N PF12731.7 KOG99372.1 - 0.0065 16.5 0.6 0.016 15.3 0.6 1.7 1 0 0 1 1 1 1 Mating-type protein beta 1 DUF1043 PF06295.12 KOG99372.1 - 0.021 14.9 3.9 0.021 14.9 3.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) DUF3800 PF12686.7 KOG99372.1 - 0.078 13.6 0.2 0.39 11.4 0.0 2.1 2 1 0 2 2 1 0 Protein of unknown function (DUF3800) V_ATPase_I PF01496.19 KOG99372.1 - 0.084 10.8 8.3 0.11 10.4 8.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cation_ATPase_N PF00690.26 KOG99372.1 - 0.1 12.3 0.1 1.3 8.8 0.1 2.6 2 0 0 2 2 2 0 Cation transporter/ATPase, N-terminus Exonuc_VII_L PF02601.15 KOG99372.1 - 0.11 12.1 2.7 0.14 11.7 2.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit GTP-bdg_M PF16360.5 KOG99372.1 - 0.16 12.6 4.7 0.18 12.4 0.8 2.6 2 1 0 2 2 2 0 GTP-binding GTPase Middle Region DUF1664 PF07889.12 KOG99372.1 - 0.18 11.8 5.7 0.58 10.2 4.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TssO PF17561.2 KOG99372.1 - 0.44 10.7 14.5 0.089 12.9 5.9 2.6 1 1 1 2 2 2 0 Type VI secretion system, TssO DUF4407 PF14362.6 KOG99372.1 - 0.48 9.7 9.0 0.015 14.6 3.2 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.12 KOG99372.1 - 0.49 10.4 10.2 1.2 9.1 10.2 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 KOG99372.1 - 0.56 9.0 18.7 0.064 12.1 13.8 1.9 2 0 0 2 2 2 0 Spc7 kinetochore protein TLE_N PF03920.15 KOG99372.1 - 0.92 9.6 8.3 0.11 12.6 1.0 2.3 1 1 1 2 2 2 0 Groucho/TLE N-terminal Q-rich domain Fez1 PF06818.15 KOG99372.1 - 1.3 9.5 14.5 0.36 11.2 7.3 2.2 1 1 1 2 2 2 0 Fez1 LMBR1 PF04791.16 KOG99372.1 - 1.8 7.4 3.6 2.3 7.0 3.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Cytochrom_B562 PF07361.11 KOG99372.1 - 2.1 9.1 8.4 2.1 9.0 2.4 2.7 2 0 0 2 2 2 0 Cytochrome b562 CCDC-167 PF15188.6 KOG99372.1 - 2.9 8.3 11.4 2.2 8.7 1.5 2.7 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Cep57_MT_bd PF06657.13 KOG99372.1 - 3.3 8.2 10.7 1.8 9.1 0.8 2.6 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 APG6_N PF17675.1 KOG99372.1 - 4.1 8.0 23.5 0.58 10.7 18.3 2.2 2 1 0 2 2 1 0 Apg6 coiled-coil region TMPIT PF07851.13 KOG99372.1 - 5.1 6.2 11.6 23 4.1 11.5 2.0 1 1 0 1 1 1 0 TMPIT-like protein Sec34 PF04136.15 KOG99372.1 - 6.6 6.6 13.6 1.4 8.7 3.6 2.7 2 1 1 3 3 3 0 Sec34-like family EMP24_GP25L PF01105.24 KOG99372.1 - 6.7 6.6 8.8 1 9.3 3.4 2.1 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD SlyX PF04102.12 KOG99372.1 - 6.8 7.4 13.6 0.37 11.4 1.3 3.5 2 1 2 4 4 3 0 SlyX Med5 PF08689.10 KOG99373.1 - 0 1501.1 65.5 0 1500.9 65.5 1.0 1 0 0 1 1 1 1 Mediator complex subunit Med5 SNF2_N PF00176.23 KOG99374.1 - 7.9e-68 228.7 2.5 2.5e-67 227.1 2.5 1.9 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 KOG99374.1 - 1.5e-47 161.3 22.9 1.5e-47 161.3 22.9 4.1 4 1 1 5 5 5 1 DNA-binding domain Helicase_C PF00271.31 KOG99374.1 - 2.8e-18 66.3 0.0 1.3e-17 64.1 0.0 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG99374.1 - 1.7e-06 28.1 0.0 1.7e-06 28.1 0.0 4.0 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOG99374.1 - 0.00043 20.1 0.0 0.0019 18.0 0.0 2.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Chorismate_synt PF01264.21 KOG99375.1 - 1.8e-140 467.3 0.0 2e-140 467.1 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Ribosomal_L6 PF00347.23 KOG99376.1 - 6.3e-31 106.9 9.9 4.7e-16 59.2 3.9 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 LRR_6 PF13516.6 KOG99376.1 - 0.026 14.6 2.0 0.17 12.0 0.4 2.9 3 0 0 3 3 3 0 Leucine Rich repeat EMP24_GP25L PF01105.24 KOG99377.1 - 1.1e-08 35.3 0.1 2e-08 34.4 0.1 1.4 1 1 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF760 PF05542.11 KOG99377.1 - 0.11 12.8 0.2 0.28 11.6 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF760) RINT1_TIP1 PF04437.13 KOG99378.1 - 9.2e-88 295.3 26.5 9.2e-88 295.3 26.5 1.8 2 0 0 2 2 2 1 RINT-1 / TIP-1 family PrkA PF06798.12 KOG99378.1 - 0.02 14.5 1.1 0.02 14.5 1.1 2.4 2 1 1 3 3 3 0 PrkA serine protein kinase C-terminal domain DUF4407 PF14362.6 KOG99378.1 - 0.46 9.8 4.7 0.76 9.1 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF676 PF05057.14 KOG99379.1 - 4.9e-60 202.8 0.0 8.1e-60 202.0 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 KOG99379.1 - 0.0058 16.5 0.0 0.009 15.9 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase LCAT PF02450.15 KOG99379.1 - 0.021 14.0 0.8 0.033 13.4 0.0 1.7 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase Abhydrolase_5 PF12695.7 KOG99379.1 - 0.047 13.5 0.1 0.088 12.6 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 KOG99379.1 - 0.058 13.3 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.13 KOG99379.1 - 0.11 12.2 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein PCRF PF03462.18 KOG99380.1 - 3e-53 180.6 1.6 1e-52 178.9 0.0 2.4 2 1 1 3 3 3 1 PCRF domain RF-1 PF00472.20 KOG99380.1 - 1.3e-38 131.5 3.5 1.3e-38 131.5 3.5 1.7 2 0 0 2 2 2 1 RF-1 domain Dynamin_N PF00350.23 KOG99380.1 - 0.094 12.8 0.1 0.094 12.8 0.1 2.1 2 1 0 2 2 2 0 Dynamin family Glyco_transf_22 PF03901.17 KOG99381.1 - 5.5e-133 444.2 31.9 6.5e-133 444.0 31.9 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family HECT PF00632.25 KOG99382.1 - 3.2e-87 292.9 0.4 6e-87 292.0 0.4 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ArAE_2_N PF10337.9 KOG99383.1 - 4.9e-105 352.3 0.7 4.9e-105 352.3 0.7 2.7 3 0 0 3 3 3 1 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 KOG99383.1 - 6.3e-15 55.4 12.8 6.3e-15 55.4 12.8 2.8 2 1 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.8 KOG99383.1 - 1.5e-09 37.3 0.4 4.2e-07 29.2 0.1 2.5 2 0 0 2 2 2 2 Aluminium activated malate transporter ArAE_2 PF10334.9 KOG99383.1 - 0.00065 19.6 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 H2TH PF06831.14 KOG99383.1 - 0.12 12.4 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase H2TH domain Pox_A_type_inc PF04508.12 KOG99383.1 - 0.19 11.6 0.4 0.49 10.3 0.4 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat ArAE_1 PF06081.11 KOG99383.1 - 4.8 7.3 6.2 2.2 8.4 1.9 2.6 2 1 0 2 2 2 0 Aromatic acid exporter family member 1 TRP PF06011.12 KOG99384.1 - 4.1e-155 516.7 40.4 6.2e-155 516.1 40.4 1.3 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 KOG99384.1 - 7.6e-40 136.5 0.6 1.3e-39 135.8 0.6 1.4 1 0 0 1 1 1 1 ML-like domain E1_DerP2_DerF2 PF02221.15 KOG99384.1 - 0.052 14.0 0.1 0.092 13.2 0.1 1.4 1 0 0 1 1 1 0 ML domain DUF1885 PF08968.10 KOG99385.1 - 0.036 14.2 0.4 0.11 12.6 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1885) Coatomer_WDAD PF04053.14 KOG99386.1 - 8.7e-167 555.7 0.1 1.4e-166 555.0 0.1 1.3 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 KOG99386.1 - 1.9e-35 120.3 5.7 9.7e-07 29.4 0.0 8.3 8 0 0 8 8 8 6 WD domain, G-beta repeat TPR_2 PF07719.17 KOG99386.1 - 0.00037 20.4 1.3 0.39 10.9 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat BBS2_Mid PF14783.6 KOG99386.1 - 0.00078 19.5 0.0 0.53 10.4 0.0 4.2 2 2 2 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 KOG99386.1 - 0.0049 15.6 3.5 0.71 8.4 0.0 4.2 2 2 2 5 5 5 1 Nucleoporin Nup120/160 TPR_1 PF00515.28 KOG99386.1 - 0.0061 16.3 0.0 2.2 8.3 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOG99386.1 - 0.03 14.5 0.4 9.9 6.7 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat MetallophosC PF16370.5 KOG99386.1 - 0.055 13.7 0.2 0.65 10.2 0.0 2.8 1 1 1 2 2 2 0 C terminal of Calcineurin-like phosphoesterase FtsJ PF01728.19 KOG99387.1 - 2.1e-49 168.0 0.0 2.7e-49 167.7 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 KOG99387.1 - 0.00036 20.4 0.0 0.00063 19.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOG99387.1 - 0.066 13.0 0.0 8.4 6.2 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Ribosomal_L1 PF00687.21 KOG99388.1 - 5.2e-40 137.4 0.6 6.1e-40 137.1 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Cyclin PF08613.11 KOG99389.1 - 3.1e-18 66.6 0.4 6.8e-18 65.6 0.4 1.5 1 0 0 1 1 1 1 Cyclin WAC_Acf1_DNA_bd PF10537.9 KOG99390.1 - 4.5e-34 117.0 0.3 4.5e-34 117.0 0.3 3.0 3 0 0 3 3 3 1 ATP-utilising chromatin assembly and remodelling N-terminal DDT PF02791.17 KOG99390.1 - 2e-12 47.3 0.1 7.9e-11 42.1 0.0 2.5 2 0 0 2 2 2 1 DDT domain WSD PF15613.6 KOG99390.1 - 7.4e-12 45.6 0.0 7.4e-12 45.6 0.0 4.1 4 0 0 4 4 4 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif INTS5_N PF14837.6 KOG99390.1 - 0.17 11.5 1.2 0.36 10.4 0.1 2.1 2 0 0 2 2 2 0 Integrator complex subunit 5 N-terminus BAH PF01426.18 KOG99391.1 - 3.3e-20 72.2 0.3 1.2e-19 70.3 0.1 2.0 2 0 0 2 2 2 1 BAH domain PHD PF00628.29 KOG99391.1 - 1.7e-11 43.8 66.6 1.4e-06 28.0 8.1 6.1 7 0 0 7 7 7 3 PHD-finger zf-HC5HC2H_2 PF13832.6 KOG99391.1 - 6.7e-11 42.3 7.8 6.7e-11 42.3 7.8 5.0 3 2 0 5 5 5 1 PHD-zinc-finger like domain PHD_2 PF13831.6 KOG99391.1 - 0.00095 18.7 25.5 0.0036 16.8 4.5 4.8 3 1 0 3 3 3 2 PHD-finger Myb_DNA-binding PF00249.31 KOG99391.1 - 0.054 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF4874 PF16173.5 KOG99391.1 - 0.1 12.3 0.4 0.86 9.3 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4874) mRNA_cap_enzyme PF01331.19 KOG99392.1 - 1.4e-69 233.9 0.0 1.2e-68 230.7 0.0 2.0 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 KOG99392.1 - 5e-33 114.0 0.4 8.6e-33 113.2 0.4 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 KOG99392.1 - 2.6e-07 30.5 0.0 0.00058 19.6 0.0 2.5 1 1 1 2 2 2 2 ATP dependent DNA ligase domain DAP3 PF10236.9 KOG99393.1 - 9.6e-91 304.2 1.8 1.2e-90 303.8 1.8 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 KOG99393.1 - 0.00065 20.1 0.0 0.0015 19.0 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOG99393.1 - 0.0032 17.7 0.1 0.025 14.8 0.1 2.3 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 KOG99393.1 - 0.0091 15.7 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_7 PF12775.7 KOG99393.1 - 0.0099 15.4 0.0 0.025 14.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_29 PF13555.6 KOG99393.1 - 0.012 15.4 0.1 0.026 14.3 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 KOG99393.1 - 0.027 13.5 0.0 0.054 12.6 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein RsgA_GTPase PF03193.16 KOG99393.1 - 0.029 14.3 0.1 0.081 12.8 0.1 1.8 1 0 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 KOG99393.1 - 0.068 12.3 0.1 0.17 11.0 0.1 1.9 1 1 0 1 1 1 0 NB-ARC domain NTPase_1 PF03266.15 KOG99393.1 - 0.12 12.3 2.0 0.34 10.8 0.0 2.7 3 1 1 4 4 4 0 NTPase IstB_IS21 PF01695.17 KOG99393.1 - 0.16 11.7 0.0 0.89 9.3 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein DnaJ PF00226.31 KOG99394.1 - 6e-18 64.7 0.4 1.3e-17 63.7 0.4 1.6 1 0 0 1 1 1 1 DnaJ domain Acyl-CoA_ox_N PF14749.6 KOG99394.1 - 0.017 15.6 0.5 0.035 14.7 0.5 1.5 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal Med31 PF05669.12 KOG99395.1 - 7.3e-26 90.0 1.5 9.4e-26 89.6 1.5 1.2 1 0 0 1 1 1 1 SOH1 Dam PF05869.11 KOG99395.1 - 0.084 12.4 0.1 0.1 12.2 0.1 1.2 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) Scs3p PF10261.9 KOG99396.1 - 4.4e-39 134.5 2.0 5.4e-39 134.2 2.0 1.1 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM MTHFR PF02219.17 KOG99397.1 - 1.3e-124 415.1 0.0 1.9e-124 414.7 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Mon1 PF03164.14 KOG99398.1 - 8.4e-143 476.3 5.6 1.2e-142 475.8 5.6 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 Ribosomal_S5 PF00333.20 KOG99399.1 - 1.2e-26 92.5 3.1 5.5e-26 90.3 1.6 2.4 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 KOG99399.1 - 2.4e-23 81.4 0.0 3.8e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Nab2 PF11517.8 KOG99400.1 - 1e-48 163.8 3.2 1.8e-48 163.0 3.2 1.4 1 0 0 1 1 1 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) zf-CCCH_2 PF14608.6 KOG99400.1 - 5e-20 71.2 72.2 3.9e-05 24.0 3.8 7.3 7 0 0 7 7 7 4 RNA-binding, Nab2-type zinc finger Nab2p_Zf1 PF18260.1 KOG99400.1 - 8.7e-17 60.7 8.6 8.7e-17 60.7 8.6 3.3 3 0 0 3 3 3 1 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 TFIIA PF03153.13 KOG99400.1 - 7.7e-05 22.9 32.2 0.00012 22.2 32.2 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CAC1F_C PF16885.5 KOG99400.1 - 0.00057 19.7 3.4 0.0011 18.7 3.4 1.4 1 0 0 1 1 1 1 Voltage-gated calcium channel subunit alpha, C-term EPL1 PF10513.9 KOG99400.1 - 0.0014 19.1 4.6 0.0022 18.4 4.6 1.5 1 0 0 1 1 1 1 Enhancer of polycomb-like DDHD PF02862.17 KOG99400.1 - 0.0045 17.2 5.4 0.0075 16.5 5.4 1.4 1 0 0 1 1 1 1 DDHD domain FAM222A PF15258.6 KOG99400.1 - 0.0067 15.6 24.1 0.012 14.7 24.1 1.4 1 0 0 1 1 1 1 Protein family of FAM222A Pex14_N PF04695.13 KOG99400.1 - 0.063 13.9 25.1 0.15 12.7 25.1 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TERB2 PF15101.6 KOG99400.1 - 0.13 12.4 14.8 0.22 11.5 14.8 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SHOCT PF09851.9 KOG99400.1 - 0.14 11.9 1.0 0.37 10.6 1.0 1.8 1 0 0 1 1 1 0 Short C-terminal domain Med15 PF09606.10 KOG99400.1 - 0.17 10.5 42.7 0.23 10.1 42.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.9 KOG99400.1 - 0.19 10.0 25.5 0.27 9.5 25.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 KOG99400.1 - 0.19 10.5 14.1 0.28 9.9 14.1 1.2 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 KOG99400.1 - 0.28 9.1 9.2 0.39 8.6 9.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Band_3_cyto PF07565.13 KOG99400.1 - 0.42 10.4 10.2 0.72 9.6 10.2 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Neur_chan_memb PF02932.16 KOG99400.1 - 0.65 10.0 11.6 0.15 12.1 6.9 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF4834 PF16118.5 KOG99400.1 - 0.73 10.8 12.4 1.7 9.6 12.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SpoIIP PF07454.11 KOG99400.1 - 1.1 8.7 13.9 1.8 8.0 13.9 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Lin-8 PF03353.15 KOG99400.1 - 1.1 8.7 19.4 2 7.9 19.4 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4407 PF14362.6 KOG99400.1 - 1.4 8.2 14.3 2.6 7.3 14.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spt20 PF12090.8 KOG99400.1 - 1.6 8.3 43.9 3.1 7.4 43.9 1.4 1 0 0 1 1 1 0 Spt20 family CobT PF06213.12 KOG99400.1 - 1.9 7.8 21.5 3 7.1 21.5 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Radical_SAM_N PF08497.10 KOG99400.1 - 2 7.6 7.0 3 7.0 7.0 1.2 1 0 0 1 1 1 0 Radical SAM N-terminal SLC12 PF03522.15 KOG99400.1 - 2.3 7.2 12.4 3.6 6.5 12.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Baculo_PP31 PF05311.11 KOG99400.1 - 2.5 7.5 10.3 4.7 6.6 10.3 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) ALMT PF11744.8 KOG99400.1 - 2.5 6.8 8.9 3.7 6.3 8.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Serinc PF03348.15 KOG99400.1 - 2.7 6.8 4.9 3.8 6.3 4.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) GREB1 PF15782.5 KOG99400.1 - 2.8 4.9 13.5 3.7 4.6 13.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RR_TM4-6 PF06459.12 KOG99400.1 - 3 7.6 13.6 6 6.6 13.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Rxt3 PF08642.10 KOG99400.1 - 3.5 8.4 6.1 7.8 7.3 6.1 1.6 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 SID-1_RNA_chan PF13965.6 KOG99400.1 - 3.7 5.8 4.6 4.9 5.4 4.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PepSY_TM PF03929.16 KOG99400.1 - 4.1 7.0 6.3 6.3 6.4 6.3 1.3 1 0 0 1 1 1 0 PepSY-associated TM region Kei1 PF08552.11 KOG99400.1 - 4.6 7.1 7.1 7.5 6.4 7.1 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 EOS1 PF12326.8 KOG99400.1 - 4.9 7.0 4.8 8.7 6.2 4.8 1.3 1 0 0 1 1 1 0 N-glycosylation protein CPSF100_C PF13299.6 KOG99400.1 - 5 7.3 11.0 9.4 6.4 11.0 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Membralin PF09746.9 KOG99400.1 - 5 6.1 8.5 7.6 5.5 8.5 1.2 1 0 0 1 1 1 0 Tumour-associated protein DUF4175 PF13779.6 KOG99400.1 - 5.2 4.9 35.0 8.1 4.2 35.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Ctr PF04145.15 KOG99400.1 - 6.9 7.3 5.5 15 6.2 5.5 1.5 1 0 0 1 1 1 0 Ctr copper transporter family Het-C PF07217.11 KOG99400.1 - 8 4.9 11.7 12 4.3 11.7 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Sec62 PF03839.16 KOG99400.1 - 8 5.9 8.1 15 5.0 8.1 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 HA2 PF04408.23 KOG99402.1 - 1.4e-22 80.0 0.0 3.1e-22 78.9 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KOG99402.1 - 1.7e-22 79.6 0.0 6.6e-22 77.7 0.0 2.0 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KOG99402.1 - 3.9e-12 46.5 0.0 1.2e-11 45.0 0.0 1.8 2 0 0 2 2 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOG99402.1 - 8e-10 38.8 0.1 1.5e-09 37.9 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOG99402.1 - 1.8e-06 28.3 0.0 6e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 KOG99402.1 - 0.00022 20.9 0.1 0.00058 19.6 0.1 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 KOG99402.1 - 0.00045 20.6 0.1 0.00084 19.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOG99402.1 - 0.0009 19.0 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 KOG99402.1 - 0.0015 18.5 0.1 0.003 17.5 0.1 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_23 PF13476.6 KOG99402.1 - 0.0034 17.9 0.0 0.023 15.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 KOG99402.1 - 0.0034 17.4 0.3 0.32 11.0 0.2 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_7 PF12775.7 KOG99402.1 - 0.024 14.2 0.0 0.079 12.5 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region T2SSE PF00437.20 KOG99402.1 - 0.047 12.8 0.0 0.1 11.6 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 KOG99402.1 - 0.08 12.7 0.1 2.1 8.0 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF2075 PF09848.9 KOG99402.1 - 0.087 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ABC1 PF03109.16 KOG99403.1 - 2.5e-36 124.5 0.0 4.7e-36 123.6 0.0 1.5 1 0 0 1 1 1 1 ABC1 family Abhydrolase_8 PF06259.12 KOG99403.1 - 0.028 14.0 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase Arfaptin PF06456.13 KOG99404.1 - 0.00031 20.4 0.2 0.00057 19.5 0.2 1.4 1 0 0 1 1 1 1 Arfaptin-like domain GCN5L1 PF06320.13 KOG99404.1 - 0.012 15.8 0.1 0.65 10.2 0.0 2.4 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) WD40 PF00400.32 KOG99405.1 - 1.7e-13 50.8 16.2 0.00011 22.9 0.2 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG99405.1 - 2.2e-13 50.3 3.1 0.00012 22.3 0.1 4.6 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOG99405.1 - 4e-07 29.3 0.1 0.00017 20.7 0.0 3.6 3 1 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF2790 PF10976.8 KOG99405.1 - 0.21 11.6 0.4 0.59 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2790) CBS PF00571.28 KOG99406.1 - 1.5e-25 89.4 4.7 1.5e-11 44.5 0.2 4.3 4 0 0 4 4 4 4 CBS domain OPT PF03169.15 KOG99407.1 - 1.7e-173 578.6 21.3 1.9e-173 578.5 21.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF1189 PF06691.11 KOG99407.1 - 3.3 7.2 9.7 0.88 9.1 5.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) SLD3 PF08639.10 KOG99408.1 - 6.5e-58 196.8 19.4 6.3e-55 187.0 19.4 2.2 1 1 0 1 1 1 1 DNA replication regulator SLD3 Sld3_N PF18523.1 KOG99408.1 - 4.8e-33 113.7 2.0 7.1e-33 113.2 0.7 2.1 2 0 0 2 2 2 1 Sld3 N-terminal domain TAF PF02969.17 KOG99409.1 - 5.2e-30 103.4 0.2 1.4e-29 102.1 0.2 1.8 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TAF6_C PF07571.13 KOG99409.1 - 1.3e-28 99.1 0.0 3.7e-28 97.7 0.0 1.8 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain Histone PF00125.24 KOG99409.1 - 0.00038 20.8 1.2 0.024 15.0 0.1 2.3 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 KOG99409.1 - 0.0048 17.2 1.2 1.2 9.5 0.1 3.3 3 0 0 3 3 3 1 CENP-S protein TAF4 PF05236.14 KOG99409.1 - 0.0075 16.1 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family TFIID-31kDa PF02291.15 KOG99409.1 - 0.008 16.2 0.3 0.024 14.7 0.3 1.8 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit DUF348 PF03990.14 KOG99409.1 - 0.035 13.8 0.0 0.095 12.5 0.0 1.7 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain CBFD_NFYB_HMF PF00808.23 KOG99409.1 - 0.18 12.1 0.3 0.74 10.1 0.1 2.2 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PQQ PF01011.21 KOG99410.1 - 0.045 13.7 0.1 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 PQQ enzyme repeat zf-CHC2 PF01807.20 KOG99410.1 - 0.094 12.5 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 CHC2 zinc finger CUE PF02845.16 KOG99411.1 - 5.4e-09 35.6 0.3 1.4e-08 34.3 0.3 1.8 1 0 0 1 1 1 1 CUE domain Asp-B-Hydro_N PF05279.11 KOG99412.1 - 4.3 7.3 15.1 4.7 7.2 15.1 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region PPR PF01535.20 KOG99413.1 - 0.003 17.7 0.1 0.03 14.6 0.1 2.8 2 0 0 2 2 2 1 PPR repeat Rsa3 PF14615.6 KOG99413.1 - 0.006 16.1 0.1 0.078 12.6 0.0 2.6 2 0 0 2 2 2 1 Ribosome-assembly protein 3 Acid_phosphat_B PF03767.14 KOG99413.1 - 0.034 13.7 0.1 0.2 11.2 0.0 2.0 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) EF-hand_7 PF13499.6 KOG99414.1 - 9.7e-13 48.4 2.1 9.2e-09 35.6 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOG99414.1 - 6.7e-10 38.1 5.1 0.00022 20.9 0.1 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KOG99414.1 - 6.8e-10 38.7 0.4 1.1e-07 31.6 0.1 2.9 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 KOG99414.1 - 2.4e-09 36.1 6.2 0.00049 19.4 0.1 3.3 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 KOG99414.1 - 1.2e-07 32.0 0.1 0.013 15.8 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain EF-hand_14 PF17959.1 KOG99414.1 - 0.007 16.7 0.1 0.65 10.4 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_11 PF08976.11 KOG99414.1 - 0.03 15.2 0.0 0.051 14.4 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain tRNA_bind PF01588.20 KOG99415.1 - 4.4e-28 97.2 0.0 7.8e-28 96.4 0.0 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain GP4 PF03010.14 KOG99415.1 - 0.028 14.3 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 GP4 DUF913 PF06025.12 KOG99415.1 - 0.13 11.3 1.0 0.18 10.8 1.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TP53IP5 PF15331.6 KOG99415.1 - 0.14 12.3 3.3 0.25 11.5 3.3 1.5 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 NARP1 PF12569.8 KOG99415.1 - 0.26 10.2 13.3 0.36 9.7 13.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RR_TM4-6 PF06459.12 KOG99415.1 - 0.93 9.3 8.4 1.5 8.6 8.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 KOG99415.1 - 4.6 5.9 5.6 6.8 5.3 5.6 1.2 1 0 0 1 1 1 0 Presenilin Sugar_tr PF00083.24 KOG99416.1 - 4.5e-91 306.0 21.4 5.6e-91 305.7 21.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG99416.1 - 1.3e-23 83.5 24.4 9.1e-18 64.3 8.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 KOG99416.1 - 0.013 14.9 15.4 0.083 12.2 1.1 4.3 2 2 3 5 5 5 0 Uncharacterised MFS-type transporter YbfB Mntp PF02659.15 KOG99416.1 - 5.8 6.7 21.3 0.035 13.8 2.9 3.9 2 2 2 4 4 4 0 Putative manganese efflux pump Ribosomal_L27A PF00828.19 KOG99417.1 - 2.2e-22 80.1 0.1 3.6e-22 79.4 0.0 1.4 1 1 1 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A HD_3 PF13023.6 KOG99418.1 - 1.3e-36 126.0 0.4 1.3e-36 126.0 0.4 1.6 2 0 0 2 2 2 1 HD domain HD_2 PF12917.7 KOG99418.1 - 1.1e-09 38.3 0.2 1.7e-09 37.7 0.2 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 KOG99418.1 - 4.9e-06 26.8 0.0 9.8e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 HD domain DUF1819 PF08849.11 KOG99418.1 - 0.057 13.2 0.3 0.057 13.2 0.3 1.6 2 0 0 2 2 2 0 Putative inner membrane protein (DUF1819) WD40 PF00400.32 KOG99419.1 - 1.3e-21 76.5 16.1 7.5e-05 23.4 0.4 5.8 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG99419.1 - 7.4e-13 48.6 0.5 0.011 16.0 0.1 4.3 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain MMR_HSR1 PF01926.23 KOG99420.1 - 2.2e-16 60.0 0.3 1.3e-14 54.2 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOG99420.1 - 7e-08 32.1 0.5 6.2e-06 25.8 0.1 2.5 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KOG99420.1 - 2.5e-07 30.8 0.3 0.004 17.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 KOG99420.1 - 0.0029 17.0 0.1 0.0061 15.9 0.1 1.5 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 KOG99420.1 - 0.024 14.7 3.0 0.089 12.8 1.4 2.8 2 1 0 2 2 2 0 Dynamin family Use1 PF09753.9 KOG99421.1 - 2e-12 47.4 1.7 3.4e-12 46.6 1.7 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 DUF1980 PF09323.10 KOG99421.1 - 0.019 14.9 2.1 0.063 13.2 2.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) adh_short PF00106.25 KOG99422.1 - 2.3e-18 66.4 0.1 2.5e-16 59.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOG99422.1 - 6.3e-10 39.0 0.0 9.5e-10 38.4 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOG99422.1 - 1.5e-07 31.5 0.0 2.3e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOG99422.1 - 0.00033 20.2 0.0 0.00046 19.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KOG99422.1 - 0.0067 16.3 0.1 0.068 13.0 0.0 2.1 2 0 0 2 2 2 1 NAD(P)H-binding THF_DHG_CYH_C PF02882.19 KOG99422.1 - 0.021 14.1 1.8 0.049 12.9 1.8 1.5 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 KOG99422.1 - 0.1 12.7 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GDP_Man_Dehyd PF16363.5 KOG99422.1 - 0.16 11.3 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RCC1 PF00415.18 KOG99423.1 - 1.7e-62 207.9 0.0 1.3e-07 32.1 0.0 7.4 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOG99423.1 - 3.3e-39 131.9 20.6 5.4e-08 32.4 0.0 7.4 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Homeobox_KN PF05920.11 KOG99424.1 - 6.9e-20 70.7 1.2 1.3e-19 69.8 1.2 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KOG99424.1 - 3.8e-07 29.8 0.1 8.9e-07 28.7 0.1 1.6 1 0 0 1 1 1 1 Homeodomain Sec1 PF00995.23 KOG99425.1 - 1.2e-123 414.3 18.8 1.4e-123 414.2 18.8 1.0 1 0 0 1 1 1 1 Sec1 family MADF_DNA_bdg PF10545.9 KOG99425.1 - 0.073 13.4 0.1 0.27 11.6 0.1 2.0 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like 3H PF02829.14 KOG99425.1 - 0.21 11.9 2.2 8.3 6.8 0.1 2.9 3 0 0 3 3 3 0 3H domain YxiJ PF14176.6 KOG99425.1 - 0.25 11.8 4.6 0.23 12.0 0.4 2.9 2 2 0 2 2 2 0 YxiJ-like protein UCH_1 PF13423.6 KOG99426.1 - 1.4e-56 192.5 3.2 1.9e-56 192.0 3.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 KOG99426.1 - 8.1e-27 94.8 0.0 3.2e-26 92.8 0.0 2.1 3 0 0 3 3 3 1 Exonuclease UCH PF00443.29 KOG99426.1 - 2.8e-06 27.0 1.7 6.6e-06 25.8 1.7 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ANAPC4_WD40 PF12894.7 KOG99426.1 - 0.0034 17.6 0.0 0.27 11.6 0.0 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Spc7 PF08317.11 KOG99427.1 - 1.7e-49 168.4 7.7 3.2e-49 167.5 7.7 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein ParA PF10609.9 KOG99428.1 - 5e-93 311.1 0.0 5.8e-93 310.9 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 KOG99428.1 - 3e-10 40.2 0.0 6.5e-10 39.1 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 KOG99428.1 - 8.9e-07 29.0 0.4 1.1e-05 25.4 0.4 2.1 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 KOG99428.1 - 6.3e-06 25.7 0.0 9.6e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 KOG99428.1 - 0.00024 20.4 1.5 0.0027 16.9 0.5 2.3 1 1 1 2 2 2 1 Anion-transporting ATPase TF_Zn_Ribbon PF08271.12 KOG99428.1 - 0.02 14.4 0.4 0.048 13.2 0.4 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding AAA_26 PF13500.6 KOG99428.1 - 0.022 14.6 0.0 0.15 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 KOG99428.1 - 0.025 14.5 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase CBP_BcsQ PF06564.12 KOG99428.1 - 0.027 14.0 0.1 0.053 13.0 0.1 1.6 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 KOG99428.1 - 0.038 13.6 0.0 0.068 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 KOG99428.1 - 0.1 12.3 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain CLP1_P PF16575.5 KOG99428.1 - 0.11 12.2 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop NB-ARC PF00931.22 KOG99428.1 - 0.12 11.5 0.1 0.19 10.9 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 KOG99428.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KOG99428.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_16 PF13191.6 KOG99428.1 - 0.16 12.3 0.0 0.23 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain XLF PF09302.11 KOG99429.1 - 4.3e-07 30.3 1.0 0.011 15.9 0.2 2.5 1 1 1 2 2 2 2 XLF-Cernunnos, XRcc4-like factor, NHEJ component MF_alpha_N PF05436.11 KOG99430.1 - 1.6e-29 101.6 0.3 2.2e-29 101.2 0.3 1.2 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus MF_alpha PF04648.12 KOG99430.1 - 1.5e-19 69.4 37.0 2.7e-06 27.4 7.6 3.2 3 0 0 3 3 3 3 Yeast mating factor alpha hormone UQ_con PF00179.26 KOG99431.1 - 1.9e-17 63.2 0.1 2.1e-17 63.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOG99431.1 - 0.0017 18.6 0.0 0.0019 18.5 0.0 1.1 1 0 0 1 1 1 1 RWD domain MAD PF05557.13 KOG99432.1 - 8.8e-24 83.9 79.1 1.4e-23 83.2 79.1 1.2 1 0 0 1 1 1 1 Mitotic checkpoint protein Tombus_P19 PF03220.13 KOG99432.1 - 0.17 11.6 1.1 14 5.3 0.0 2.9 3 0 0 3 3 3 0 Tombusvirus P19 core protein FAA_hydro_N_2 PF18288.1 KOG99432.1 - 5.9 7.4 6.0 7.8 7.0 0.2 3.6 3 0 0 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 SNase PF00565.17 KOG99433.1 - 2.1e-28 98.9 0.0 3.4e-28 98.3 0.0 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue MBOAT PF03062.19 KOG99434.1 - 7.4e-81 272.2 27.4 7.4e-81 272.2 27.4 1.5 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Pkinase PF00069.25 KOG99435.1 - 3.3e-21 75.8 0.1 6e-21 75.0 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99435.1 - 2.1e-09 37.1 0.0 3.7e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DCB PF16213.5 KOG99435.1 - 0.00044 20.0 1.5 0.00092 18.9 1.5 1.5 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 MINDY_DUB PF04424.13 KOG99436.1 - 9.5e-29 99.8 0.0 1.8e-28 98.9 0.0 1.5 1 0 0 1 1 1 1 MINDY deubiquitinase FHA PF00498.26 KOG99437.1 - 5.3e-07 29.9 0.1 1.9e-06 28.1 0.1 2.0 2 0 0 2 2 2 1 FHA domain Myc_N PF01056.18 KOG99437.1 - 0.082 12.8 3.7 0.1 12.5 3.7 1.2 1 0 0 1 1 1 0 Myc amino-terminal region MPC PF03650.13 KOG99438.1 - 1.4e-41 141.0 0.0 1.7e-41 140.8 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers KxDL PF10241.9 KOG99439.1 - 4.8e-23 81.2 0.9 3.7e-22 78.4 0.8 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein DEAD PF00270.29 KOG99440.1 - 2.9e-54 183.5 0.1 2.6e-53 180.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG99440.1 - 2.5e-37 127.6 0.5 1.8e-31 108.7 0.0 3.2 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 KOG99440.1 - 1.4e-08 34.9 5.1 5.5e-08 33.0 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOG99440.1 - 9.8e-05 21.7 0.0 9.8e-05 21.7 0.0 2.7 3 0 0 3 3 2 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 KOG99440.1 - 0.00091 18.6 13.1 0.0029 17.0 0.0 2.5 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit AAA_30 PF13604.6 KOG99440.1 - 0.0028 17.4 0.0 0.14 11.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOG99440.1 - 0.0061 16.9 0.1 0.38 11.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain UTP25 PF06862.12 KOG99440.1 - 0.0068 15.2 0.1 0.0068 15.2 0.1 2.8 3 1 0 3 3 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CAMSAP_CKK PF08683.11 KOG99440.1 - 0.017 15.3 0.6 4.3 7.5 0.0 3.1 3 0 0 3 3 3 0 Microtubule-binding calmodulin-regulated spectrin-associated Zip PF02535.22 KOG99440.1 - 0.32 10.2 2.1 0.42 9.8 2.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3438 PF11920.8 KOG99440.1 - 2 7.6 5.2 3.5 6.8 5.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) Vfa1 PF08432.10 KOG99440.1 - 4.7 7.5 21.1 11 6.3 21.1 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 AA_permease_2 PF13520.6 KOG99441.1 - 2.4e-50 171.6 47.2 2.7e-50 171.4 47.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOG99441.1 - 1.3e-17 63.6 38.8 1.8e-17 63.1 38.8 1.0 1 0 0 1 1 1 1 Amino acid permease MPS2 PF17060.5 KOG99442.1 - 5e-120 401.2 12.8 5.7e-120 401.0 12.8 1.0 1 0 0 1 1 1 1 Monopolar spindle protein 2 LMBR1 PF04791.16 KOG99442.1 - 0.012 14.6 5.7 0.015 14.2 5.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein HOOK PF05622.12 KOG99442.1 - 0.016 13.4 12.4 0.021 13.0 12.4 1.1 1 0 0 1 1 1 0 HOOK protein CENP-Q PF13094.6 KOG99442.1 - 0.027 14.7 14.4 0.22 11.7 14.4 2.0 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit HJURP_C PF12347.8 KOG99442.1 - 0.042 13.9 0.8 0.1 12.7 0.4 1.8 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat Fez1 PF06818.15 KOG99442.1 - 0.065 13.7 13.0 0.11 12.9 13.0 1.3 1 0 0 1 1 1 0 Fez1 DUF4407 PF14362.6 KOG99442.1 - 0.089 12.1 4.7 0.13 11.6 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Vir_act_alpha_C PF10400.9 KOG99442.1 - 0.16 12.6 3.3 4.2 8.1 0.1 2.5 2 0 0 2 2 2 0 Virulence activator alpha C-term ALMT PF11744.8 KOG99442.1 - 0.2 10.4 6.4 0.27 10.0 6.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DHR10 PF18595.1 KOG99442.1 - 0.25 11.4 18.2 0.37 10.9 11.0 2.9 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain Exonuc_VII_L PF02601.15 KOG99442.1 - 0.3 10.6 10.0 0.49 9.9 10.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit MciZ PF13072.6 KOG99442.1 - 0.32 10.8 1.0 0.73 9.7 1.0 1.6 1 0 0 1 1 1 0 Mother cell inhibitor of FtsZ DUF2951 PF11166.8 KOG99442.1 - 0.39 11.0 12.8 1.5 9.1 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2951) DUF1664 PF07889.12 KOG99442.1 - 0.52 10.3 9.4 0.26 11.3 4.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) MAD PF05557.13 KOG99442.1 - 0.66 8.3 20.1 2.8 6.2 20.2 1.8 1 1 0 1 1 1 0 Mitotic checkpoint protein NPV_P10 PF05531.12 KOG99442.1 - 0.8 10.2 5.3 2.7 8.5 0.4 2.8 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 KOG99442.1 - 1.3 9.2 12.1 4.2 7.6 12.0 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Uso1_p115_C PF04871.13 KOG99442.1 - 1.4 9.3 10.8 2.4 8.5 10.8 1.4 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Bap31_Bap29_C PF18035.1 KOG99442.1 - 1.9 8.6 9.1 8.2 6.5 0.0 3.3 3 0 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain FAM76 PF16046.5 KOG99442.1 - 8.8 5.6 17.2 0.37 10.1 8.1 2.1 1 1 1 2 2 2 0 FAM76 protein HSF_DNA-bind PF00447.17 KOG99443.1 - 8.8e-31 106.4 3.6 2.9e-30 104.7 3.6 1.9 1 0 0 1 1 1 1 HSF-type DNA-binding AFT PF08731.11 KOG99444.1 - 6e-48 161.9 3.5 6e-48 161.9 3.5 2.3 2 0 0 2 2 2 1 Transcription factor AFT DBD_Tnp_Mut PF03108.15 KOG99444.1 - 0.1 12.6 2.2 5.7 7.0 0.9 2.5 2 0 0 2 2 2 0 MuDR family transposase FAD_binding_3 PF01494.19 KOG99444.1 - 0.15 11.3 0.7 0.26 10.5 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain UPF0449 PF15136.6 KOG99444.1 - 6.6 7.3 11.3 1.8 9.1 5.0 2.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 RNA_POL_M_15KD PF02150.16 KOG99445.1 - 1.4e-17 63.3 4.4 1.4e-17 63.3 4.4 3.0 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 KOG99445.1 - 1.5e-14 53.6 2.3 1.5e-14 53.6 2.3 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Zn_Tnp_IS1595 PF12760.7 KOG99445.1 - 0.026 14.5 10.7 0.19 11.7 2.6 2.6 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zf-UBP PF02148.19 KOG99445.1 - 0.027 14.8 4.5 0.35 11.2 0.5 2.3 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein DUF2387 PF09526.10 KOG99445.1 - 0.033 14.4 4.8 1.2 9.3 0.2 2.5 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) DZR PF12773.7 KOG99445.1 - 0.065 13.3 7.4 1.5 8.9 0.4 2.5 2 1 0 2 2 2 0 Double zinc ribbon Lar_restr_allev PF14354.6 KOG99445.1 - 0.13 12.7 0.3 0.13 12.7 0.3 2.5 2 1 0 2 2 2 0 Restriction alleviation protein Lar zinc_ribbon_10 PF10058.9 KOG99445.1 - 0.29 10.9 7.6 1.3 8.8 0.5 2.5 2 1 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Cytochrom_c3_2 PF14537.6 KOG99445.1 - 0.34 11.4 3.8 0.53 10.8 0.6 2.2 2 0 0 2 2 2 0 Cytochrome c3 Rubredoxin PF00301.20 KOG99445.1 - 1 9.4 4.7 35 4.5 0.2 3.3 4 0 0 4 4 4 0 Rubredoxin Nudix_N_2 PF14803.6 KOG99445.1 - 1.2 9.1 10.7 0.89 9.5 1.1 3.2 3 0 0 3 3 3 0 Nudix N-terminal RPA_interact_C PF14768.6 KOG99445.1 - 2.1 9.0 9.0 3.4 8.3 0.8 2.5 2 1 0 2 2 2 0 Replication protein A interacting C-terminal Cytochrome_C7 PF14522.6 KOG99445.1 - 7.4 6.7 8.3 63 3.7 8.3 2.4 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c Ribosomal_L12 PF00542.19 KOG99446.1 - 7e-24 84.0 12.9 2.5e-23 82.2 9.3 2.4 2 1 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 KOG99446.1 - 1.2e-11 44.1 10.7 1.2e-10 41.0 6.8 3.1 2 1 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain DUF2624 PF11116.8 KOG99446.1 - 0.29 12.1 3.3 14 6.7 0.2 2.9 2 1 0 3 3 3 0 Protein of unknown function (DUF2624) NUDIX PF00293.28 KOG99447.1 - 1e-14 54.7 0.0 2.2e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain zf-NADH-PPase PF09297.11 KOG99447.1 - 1.3e-06 27.9 0.1 2.7e-06 26.9 0.1 1.6 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain TGT_C2 PF14810.6 KOG99447.1 - 0.011 15.9 0.0 0.075 13.2 0.0 2.3 2 0 0 2 2 2 0 Patch-forming domain C2 of tRNA-guanine transglycosylase SCA7 PF08313.12 KOG99448.1 - 2.1e-30 104.4 0.4 9e-30 102.4 0.4 2.1 1 0 0 1 1 1 1 SCA7, zinc-binding domain zf_C2H2_13 PF18508.1 KOG99448.1 - 1.8e-22 78.7 0.4 3.5e-22 77.7 0.4 1.5 1 0 0 1 1 1 1 Zinc finger domain BUD22 PF09073.10 KOG99448.1 - 3.6 6.8 77.1 0.019 14.4 29.7 3.2 3 0 0 3 3 3 0 BUD22 Glycos_transf_1 PF00534.20 KOG99449.1 - 5.4e-53 179.1 0.1 9e-53 178.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KOG99449.1 - 4.8e-17 62.5 0.0 8.7e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 KOG99449.1 - 6.1e-10 39.7 0.0 3.1e-09 37.3 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 KOG99449.1 - 0.004 17.6 0.0 0.03 14.8 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain ALG11_N PF15924.5 KOG99449.1 - 0.045 13.8 1.9 13 5.8 0.0 2.9 1 1 1 2 2 2 0 ALG11 mannosyltransferase N-terminus DEAD PF00270.29 KOG99450.1 - 3e-35 121.6 0.3 8.1e-35 120.2 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG99450.1 - 1.7e-18 67.0 0.3 1.6e-13 51.0 0.0 3.1 3 1 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 KOG99450.1 - 2.8e-09 37.2 0.8 9.4e-09 35.5 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOG99450.1 - 0.061 13.6 0.4 0.56 10.5 0.4 2.4 1 1 0 1 1 1 0 AAA domain Helicase_C_2 PF13307.6 KOG99450.1 - 0.13 12.5 0.1 9.2 6.4 0.1 2.7 2 1 0 2 2 2 0 Helicase C-terminal domain PseudoU_synth_1 PF01416.20 KOG99451.1 - 1.1e-21 77.3 0.0 1.7e-17 63.9 0.1 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase PG_binding_2 PF08823.11 KOG99451.1 - 0.038 14.3 0.0 0.27 11.6 0.0 2.2 2 0 0 2 2 2 0 Putative peptidoglycan binding domain DUF2267 PF10025.9 KOG99451.1 - 0.095 13.0 0.0 12 6.2 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2267) HoxA13_N PF12284.8 KOG99451.1 - 0.11 13.1 0.0 0.21 12.2 0.0 1.5 1 0 0 1 1 1 0 Hox protein A13 N terminal CPSase_L_D2 PF02786.17 KOG99452.1 - 1.1e-84 283.2 0.1 1.9e-84 282.4 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 KOG99452.1 - 1.1e-67 227.7 0.0 1.8e-67 226.9 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 KOG99452.1 - 3.5e-39 133.7 0.1 8e-39 132.6 0.1 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KOG99452.1 - 9.8e-31 106.1 0.0 2.6e-30 104.7 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 KOG99452.1 - 1e-28 100.7 0.1 2e-28 99.7 0.1 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 KOG99452.1 - 1.7e-19 69.4 2.5 1.7e-19 69.4 2.5 2.2 3 0 0 3 3 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 KOG99452.1 - 4.6e-08 32.8 1.5 0.002 17.9 0.2 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.22 KOG99452.1 - 1.1e-07 31.6 0.0 2.3e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KOG99452.1 - 1.9e-06 27.6 0.0 3.9e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 KOG99452.1 - 2.3e-05 24.5 0.0 7.5e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain HlyD_D23 PF16576.5 KOG99452.1 - 3.6e-05 23.1 0.1 0.0027 17.0 0.1 2.5 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 KOG99452.1 - 0.0019 18.9 0.5 0.73 10.6 0.1 3.3 1 1 1 2 2 2 1 HlyD family secretion protein ATP-grasp_4 PF13535.6 KOG99452.1 - 0.0025 17.4 0.0 0.0059 16.2 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 KOG99452.1 - 0.0042 16.4 0.0 0.0095 15.2 0.0 1.5 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp RnfC_N PF13375.6 KOG99452.1 - 0.0043 17.0 2.0 0.067 13.2 0.4 2.8 2 0 0 2 2 2 1 RnfC Barrel sandwich hybrid domain NQRA PF05896.11 KOG99452.1 - 0.017 14.5 0.2 0.032 13.7 0.2 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) DASH_Duo1 PF08651.10 KOG99453.1 - 6.4e-21 73.9 0.4 6.4e-21 73.9 0.4 2.3 1 1 1 2 2 2 1 DASH complex subunit Duo1 DUF948 PF06103.11 KOG99453.1 - 0.47 10.7 2.7 1.9 8.8 2.0 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) BCDHK_Adom3 PF10436.9 KOG99454.1 - 2.7e-29 102.1 1.8 4.1e-29 101.5 0.8 1.8 1 1 1 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 KOG99454.1 - 0.00041 20.8 0.0 0.16 12.5 0.0 2.6 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4170 PF13773.6 KOG99454.1 - 0.09 12.9 0.0 0.26 11.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4170) UQ_con PF00179.26 KOG99455.1 - 4.1e-51 172.3 0.1 4.8e-51 172.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOG99455.1 - 0.012 15.3 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 KOG99455.1 - 0.038 14.3 0.1 0.081 13.2 0.1 1.7 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 KOG99455.1 - 0.063 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 UEV domain Leuk-A4-hydro_C PF09127.11 KOG99455.1 - 0.066 13.3 0.1 0.9 9.6 0.1 2.1 1 1 0 1 1 1 0 Leukotriene A4 hydrolase, C-terminal PBP1_TM PF14812.6 KOG99455.1 - 8.1 6.9 12.0 15 6.0 12.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CBS PF00571.28 KOG99457.1 - 1.3e-19 70.4 2.1 0.00025 21.4 0.0 5.3 5 0 0 5 5 5 5 CBS domain FA_desaturase PF00487.24 KOG99458.1 - 1.1e-18 68.0 18.8 1.1e-18 68.0 18.8 1.6 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 KOG99458.1 - 3.6e-15 55.9 0.1 1.3e-14 54.1 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Cornichon PF03311.14 KOG99459.1 - 3.2e-48 163.1 8.9 3.8e-48 162.8 8.9 1.0 1 0 0 1 1 1 1 Cornichon protein TYW3 PF02676.14 KOG99460.1 - 9e-66 221.3 0.0 1.3e-65 220.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase TYW3 MIF4G PF02854.19 KOG99461.1 - 8.1e-51 172.7 0.3 1.5e-50 171.8 0.3 1.4 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 KOG99461.1 - 1.2e-23 83.1 0.4 3.5e-23 81.5 0.4 1.8 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 AAA PF00004.29 KOG99462.1 - 2.5e-43 147.7 0.0 4.7e-43 146.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG99462.1 - 4e-14 52.1 0.5 1.2e-13 50.7 0.0 2.0 3 0 0 3 3 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 KOG99462.1 - 3.6e-07 30.0 1.0 8.7e-07 28.8 1.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 KOG99462.1 - 6.1e-07 29.7 0.0 1.4e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KOG99462.1 - 1.7e-06 28.1 0.0 7.3e-06 26.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOG99462.1 - 2.4e-05 24.8 0.1 0.00031 21.1 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KOG99462.1 - 2.9e-05 24.4 0.2 0.009 16.3 0.0 2.5 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 KOG99462.1 - 0.0001 22.1 0.0 0.00021 21.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 KOG99462.1 - 0.0015 18.3 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 KOG99462.1 - 0.0015 19.0 0.3 0.021 15.3 0.0 2.7 3 1 0 3 3 3 1 AAA domain AAA_33 PF13671.6 KOG99462.1 - 0.0021 18.2 0.0 0.0048 17.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOG99462.1 - 0.0044 17.3 0.0 0.0087 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 KOG99462.1 - 0.0069 16.2 0.0 0.019 14.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF2072 PF09845.9 KOG99462.1 - 0.0075 16.5 0.7 0.017 15.4 0.7 1.6 1 0 0 1 1 1 1 Zn-ribbon containing protein TIP49 PF06068.13 KOG99462.1 - 0.0098 15.1 0.0 0.028 13.6 0.0 1.7 1 1 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 KOG99462.1 - 0.013 14.9 0.0 0.028 13.8 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 KOG99462.1 - 0.015 15.4 0.0 0.033 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KOG99462.1 - 0.018 14.5 0.0 0.077 12.4 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein TsaE PF02367.17 KOG99462.1 - 0.019 15.0 0.0 0.038 14.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 KOG99462.1 - 0.034 13.9 0.0 0.17 11.6 0.0 2.1 3 0 0 3 3 3 0 Sigma-54 interaction domain RNA_helicase PF00910.22 KOG99462.1 - 0.039 14.3 0.0 0.085 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 KOG99462.1 - 0.049 13.2 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KOG99462.1 - 0.049 13.3 0.0 0.19 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KOG99462.1 - 0.086 12.3 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 KOG99462.1 - 0.096 11.8 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Parvo_NS1 PF01057.17 KOG99462.1 - 0.1 11.6 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATG16 PF08614.11 KOG99462.1 - 0.11 12.7 2.3 0.19 11.9 2.3 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) AAA_30 PF13604.6 KOG99462.1 - 0.14 11.8 0.0 0.33 10.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF3372 PF11852.8 KOG99462.1 - 0.15 11.6 0.2 0.26 10.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3372) NACHT PF05729.12 KOG99462.1 - 0.15 12.0 0.0 0.44 10.5 0.0 1.8 2 0 0 2 2 2 0 NACHT domain Glyco_tran_28_C PF04101.16 KOG99463.1 - 1.7e-31 109.4 0.0 3.5e-31 108.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Arrestin_N PF00339.29 KOG99464.1 - 3.5e-28 98.5 0.0 1.2e-27 96.8 0.0 2.0 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 KOG99464.1 - 1.3e-09 38.6 0.2 1.3e-09 38.6 0.2 3.0 2 1 1 3 3 3 1 Arrestin (or S-antigen), C-terminal domain DUF4692 PF15763.5 KOG99464.1 - 0.17 12.3 4.6 0.5 10.8 4.6 1.7 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) ERp29 PF07749.12 KOG99464.1 - 0.52 11.3 2.5 4.9 8.1 0.0 3.0 3 0 0 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain RRM_1 PF00076.22 KOG99465.1 - 2.7e-20 72.0 0.0 4.6e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 KOG99465.1 - 1.7e-10 40.3 1.0 3.4e-10 39.3 1.0 1.5 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal CSTF2_hinge PF14327.6 KOG99465.1 - 5.7e-05 23.5 0.3 0.00015 22.2 0.0 1.8 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_occluded PF16842.5 KOG99465.1 - 0.014 15.2 0.0 0.037 13.9 0.0 1.7 2 0 0 2 2 2 0 Occluded RNA-recognition motif RRM_7 PF16367.5 KOG99465.1 - 0.055 13.6 0.0 0.23 11.6 0.0 2.0 1 1 0 1 1 1 0 RNA recognition motif Med30 PF11315.8 KOG99465.1 - 0.13 12.5 0.3 0.13 12.5 0.3 1.6 2 0 0 2 2 2 0 Mediator complex subunit 30 Menin PF05053.13 KOG99465.1 - 8.2 4.7 10.6 11 4.2 10.6 1.1 1 0 0 1 1 1 0 Menin TFIIS_M PF07500.14 KOG99466.1 - 5.4e-23 81.6 0.1 5.4e-23 81.6 0.1 1.9 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 KOG99466.1 - 1.7e-17 62.9 6.4 3.2e-17 62.1 6.4 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 KOG99466.1 - 4.1e-10 39.5 0.8 1.1e-09 38.1 0.8 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain DUF4484 PF14831.6 KOG99466.1 - 0.0034 17.5 0.8 0.0049 16.9 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) ComZ PF10815.8 KOG99467.1 - 0.0019 18.2 0.4 0.004 17.1 0.4 1.6 1 0 0 1 1 1 1 ComZ LEM PF03020.15 KOG99467.1 - 0.45 10.1 4.5 38 3.9 0.1 4.1 3 2 1 4 4 4 0 LEM domain ALAD PF00490.21 KOG99468.1 - 2.2e-118 395.1 0.0 2.6e-118 394.8 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Epimerase PF01370.21 KOG99469.1 - 9.2e-13 48.2 0.0 1.3e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOG99469.1 - 1.8e-12 46.9 0.0 2.3e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 KOG99469.1 - 1e-08 34.7 0.1 2e-07 30.5 0.1 2.0 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 KOG99469.1 - 2.4e-08 33.8 0.1 5.4e-08 32.6 0.1 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase KR PF08659.10 KOG99469.1 - 9.5e-06 25.6 0.0 1.9e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 KOG99469.1 - 1.7e-05 24.4 0.1 0.00023 20.7 0.0 2.4 2 1 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 KOG99469.1 - 6.7e-05 22.9 0.0 9.5e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 KOG99469.1 - 0.00027 20.2 0.2 0.00037 19.7 0.2 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 KOG99469.1 - 0.0058 16.2 0.1 0.027 14.0 0.1 1.9 2 0 0 2 2 2 1 NmrA-like family Gly_transf_sug PF04488.15 KOG99470.1 - 1.3e-14 54.6 0.0 3.4e-14 53.3 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 KOG99470.1 - 0.052 12.9 1.1 0.18 11.2 1.0 2.1 1 1 0 1 1 1 0 Capsular polysaccharide synthesis protein Isochorismatase PF00857.20 KOG99471.1 - 2e-28 99.7 0.2 3.2e-28 99.1 0.2 1.3 1 1 0 1 1 1 1 Isochorismatase family DUF771 PF05595.11 KOG99471.1 - 0.069 13.1 0.3 0.15 12.1 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF771) Pyr_redox_2 PF07992.14 KOG99471.1 - 0.098 11.9 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase zf-C2H2 PF00096.26 KOG99473.1 - 1.7e-06 28.2 13.6 0.0036 17.7 1.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOG99473.1 - 3.6e-06 27.1 15.6 6.1e-05 23.3 1.9 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOG99473.1 - 0.0015 19.2 11.1 0.28 12.1 3.4 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger DUF243 PF03103.17 KOG99473.1 - 0.3 11.4 4.3 0.32 11.3 0.7 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF243) AGA2 PF17366.2 KOG99475.1 - 2.5e-27 94.3 5.6 3e-27 94.1 5.6 1.1 1 0 0 1 1 1 1 A-agglutinin-binding subunit Aga2 Ribosomal_L24e PF01246.20 KOG99476.1 - 8.5e-29 99.6 0.3 8.5e-29 99.6 0.3 1.9 2 0 0 2 2 2 1 Ribosomal protein L24e Ribosomal_L7Ae PF01248.26 KOG99477.1 - 9.4e-07 28.5 0.0 9.5e-07 28.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Cgr1 PF03879.14 KOG99478.1 - 3.3e-33 114.3 27.1 4e-33 114.0 27.1 1.1 1 0 0 1 1 1 1 Cgr1 family DUF2048 PF09752.9 KOG99478.1 - 0.062 12.4 3.8 0.076 12.1 3.8 1.1 1 0 0 1 1 1 0 Abhydrolase domain containing 18 DUF5401 PF17380.2 KOG99478.1 - 0.14 10.2 16.0 0.15 10.1 16.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) FapA PF03961.13 KOG99478.1 - 1.3 7.5 10.0 1.4 7.5 10.0 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A SOG2 PF10428.9 KOG99479.1 - 0.079 12.1 35.7 0.13 11.5 35.7 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Macoilin PF09726.9 KOG99479.1 - 1.9 6.9 27.4 2.6 6.5 27.4 1.1 1 0 0 1 1 1 0 Macoilin family Membralin PF09746.9 KOG99479.1 - 2.1 7.3 3.7 3.1 6.7 3.7 1.2 1 0 0 1 1 1 0 Tumour-associated protein TFIIA PF03153.13 KOG99479.1 - 6.2 6.7 21.8 9.1 6.2 21.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF812 PF05667.11 KOG99479.1 - 9.1 5.0 12.6 12 4.7 12.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Glyco_hydro_63 PF03200.16 KOG99480.1 - 2e-180 600.8 2.5 2e-180 600.8 2.5 1.9 2 1 0 2 2 2 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 KOG99480.1 - 8.9e-63 212.4 0.0 1.5e-62 211.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain FlaE PF07559.14 KOG99480.1 - 0.0073 16.9 0.0 0.017 15.7 0.0 1.7 1 1 0 1 1 1 1 Flagellar basal body protein FlaE Trp_syntA PF00290.20 KOG99481.1 - 7.8e-102 339.6 0.2 1.2e-101 339.0 0.2 1.2 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 KOG99481.1 - 1.2e-45 156.2 2.1 3.5e-45 154.7 0.8 2.0 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Med3 PF11593.8 KOG99482.1 - 3.8e-160 533.5 44.7 4.4e-160 533.3 44.7 1.0 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal DUF973 PF06157.11 KOG99482.1 - 1.5 7.8 3.1 3 6.8 3.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF973) FYVE PF01363.21 KOG99483.1 - 3.5e-15 55.9 6.4 8.4e-15 54.7 6.4 1.7 1 0 0 1 1 1 1 FYVE zinc finger IATP PF04568.12 KOG99483.1 - 0.29 11.6 2.9 2.1 8.8 2.0 2.5 1 1 1 2 2 2 0 Mitochondrial ATPase inhibitor, IATP zf_C2HC_14 PF18574.1 KOG99483.1 - 5.1 7.0 6.5 10 6.0 6.5 1.4 1 0 0 1 1 1 0 C2HC Zing finger domain STT3 PF02516.14 KOG99484.1 - 4.6e-158 527.2 48.0 7.3e-156 519.9 44.4 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit Haspin_kinase PF12330.8 KOG99485.1 - 3.3e-122 408.0 13.8 3.3e-122 408.0 13.8 2.5 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 KOG99485.1 - 0.0016 18.4 0.0 0.0027 17.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 KOG99485.1 - 0.0033 17.0 0.2 0.011 15.4 0.2 1.9 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 KOG99485.1 - 0.029 13.8 0.1 0.062 12.7 0.1 1.6 1 0 0 1 1 1 0 Protein kinase domain L_protein_N PF15518.6 KOG99485.1 - 0.068 13.0 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 L protein N-terminus MADF_DNA_bdg PF10545.9 KOG99485.1 - 2.7 8.4 5.9 0.61 10.4 1.4 2.3 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like CHD5 PF04420.14 KOG99486.1 - 6e-44 149.7 4.1 8.6e-44 149.2 4.1 1.2 1 0 0 1 1 1 1 CHD5-like protein Tmemb_40 PF10160.9 KOG99486.1 - 0.018 14.5 0.9 0.034 13.6 0.8 1.5 1 1 0 1 1 1 0 Predicted membrane protein DUF16 PF01519.16 KOG99486.1 - 0.024 15.1 0.4 0.043 14.3 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 Seryl_tRNA_N PF02403.22 KOG99486.1 - 0.028 14.6 0.6 0.046 13.9 0.6 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Syntaxin_2 PF14523.6 KOG99486.1 - 0.062 13.7 2.1 0.1 12.9 2.1 1.3 1 0 0 1 1 1 0 Syntaxin-like protein DUF4407 PF14362.6 KOG99486.1 - 0.097 12.0 0.2 0.14 11.5 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5446 PF17522.2 KOG99486.1 - 0.15 12.3 0.8 0.33 11.2 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5446) DUF4446 PF14584.6 KOG99486.1 - 0.52 10.3 2.8 4.9 7.1 2.2 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) CK_II_beta PF01214.18 KOG99487.1 - 2e-69 233.0 0.9 5.5e-69 231.6 0.9 1.6 1 1 0 1 1 1 1 Casein kinase II regulatory subunit Drc1-Sld2 PF11719.8 KOG99487.1 - 0.069 12.7 2.0 0.092 12.3 2.0 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein CDC45 PF02724.14 KOG99487.1 - 6 5.0 6.6 8.2 4.6 6.6 1.1 1 0 0 1 1 1 0 CDC45-like protein HSCB_C PF07743.13 KOG99488.1 - 4.4e-18 65.6 5.4 1.8e-16 60.4 1.4 2.2 2 0 0 2 2 2 2 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 KOG99488.1 - 2e-09 37.4 0.3 6.8e-09 35.7 0.3 1.8 1 0 0 1 1 1 1 DnaJ domain Ran_BP1 PF00638.18 KOG99488.1 - 0.06 13.6 0.0 0.093 13.0 0.0 1.3 1 0 0 1 1 1 0 RanBP1 domain ATE_C PF04377.15 KOG99489.1 - 4.6e-45 153.5 1.0 9.7e-45 152.5 1.0 1.5 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 KOG99489.1 - 2.9e-24 85.2 1.1 6e-24 84.2 1.1 1.6 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus UME PF08064.13 KOG99490.1 - 6.9 6.6 6.5 8.1 6.4 0.0 4.0 6 0 0 6 6 6 0 UME (NUC010) domain IBN_N PF03810.19 KOG99490.1 - 9.5 6.2 8.9 0.51 10.3 0.3 3.4 4 0 0 4 4 4 0 Importin-beta N-terminal domain PUF PF00806.19 KOG99492.1 - 9.2e-67 217.2 18.8 8.2e-10 37.8 0.1 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 KOG99492.1 - 0.0017 18.7 0.4 1.3 9.4 0.1 4.0 2 2 1 3 3 3 1 CPL (NUC119) domain Virul_Fac PF10139.9 KOG99492.1 - 0.01 14.1 0.4 0.015 13.5 0.4 1.2 1 0 0 1 1 1 0 Putative bacterial virulence factor Fungal_trans PF04082.18 KOG99493.1 - 4.7e-60 202.9 6.6 4.7e-60 202.9 6.6 2.5 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOG99493.1 - 4.7e-09 36.2 15.3 4.7e-09 36.2 15.3 2.5 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MAGE_N PF12440.8 KOG99493.1 - 0.18 12.5 1.0 22 5.8 0.1 2.8 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal ERG4_ERG24 PF01222.17 KOG99494.1 - 8.4e-191 634.4 31.5 9.5e-191 634.2 31.5 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Proteasome PF00227.26 KOG99495.1 - 6.2e-47 159.5 0.0 9.4e-47 159.0 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOG99495.1 - 2.1e-15 56.1 0.1 3.8e-15 55.2 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature pP_pnuc_2 PF18166.1 KOG99495.1 - 0.1 12.7 0.1 0.19 11.8 0.1 1.4 1 0 0 1 1 1 0 Predicted pPIWI-associating nuclease Phage_holin_6_1 PF09682.10 KOG99495.1 - 0.16 12.4 0.7 0.25 11.8 0.2 1.6 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) DUF962 PF06127.11 KOG99496.1 - 1.5e-28 98.8 0.1 2.6e-28 97.9 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Aconitase PF00330.20 KOG99497.1 - 2.8e-159 531.0 0.1 3.6e-159 530.7 0.1 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KOG99497.1 - 2.2e-46 157.4 0.0 4.8e-46 156.3 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain E1-E2_ATPase PF00122.20 KOG99498.1 - 9.9e-50 168.6 4.3 4.1e-49 166.6 3.4 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KOG99498.1 - 1.2e-18 68.2 0.1 3.7e-18 66.6 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOG99498.1 - 1.7e-10 40.4 0.7 3.3e-10 39.5 0.0 1.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOG99498.1 - 0.0025 17.6 0.1 0.0056 16.5 0.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOG99498.1 - 0.0041 17.2 0.0 0.0078 16.3 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_C PF00689.21 KOG99500.1 - 9.5e-43 146.0 9.5 9.5e-43 146.0 9.5 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KOG99500.1 - 9.7e-36 123.0 0.1 9.7e-36 123.0 0.1 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 KOG99500.1 - 2.1e-17 63.0 0.0 5.7e-17 61.6 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOG99500.1 - 1.2e-15 58.4 0.1 2.7e-14 54.0 0.1 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOG99500.1 - 9.8e-07 28.4 0.0 3.2e-06 26.7 0.0 2.0 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOG99500.1 - 0.0009 19.0 0.3 0.0009 19.0 0.3 2.5 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase DUF2207 PF09972.9 KOG99500.1 - 0.43 9.3 3.7 1.7 7.3 0.4 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) SR-25 PF10500.9 KOG99500.1 - 3.7 7.1 7.7 7.4 6.1 7.7 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med11 PF10280.9 KOG99501.1 - 0.00098 19.6 2.5 0.0027 18.2 2.5 1.8 1 0 0 1 1 1 1 Mediator complex protein Syntaxin-6_N PF09177.11 KOG99501.1 - 0.03 14.9 12.4 0.54 10.8 1.2 3.4 1 1 2 3 3 3 0 Syntaxin 6, N-terminal Peptidase_M19 PF01244.21 KOG99501.1 - 0.033 13.3 0.1 0.043 13.0 0.1 1.2 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) Laminin_II PF06009.12 KOG99501.1 - 0.35 10.9 8.5 0.059 13.4 2.9 2.2 1 1 1 2 2 2 0 Laminin Domain II TMF_TATA_bd PF12325.8 KOG99501.1 - 0.78 10.0 8.7 0.21 11.8 1.7 3.0 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding BLOC1_2 PF10046.9 KOG99501.1 - 2.3 8.5 12.0 1.1 9.7 2.6 3.5 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 KOG99501.1 - 2.8 8.5 9.5 0.17 12.3 1.2 3.0 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein WD40 PF00400.32 KOG99502.1 - 1.7e-16 60.2 0.7 0.00018 22.2 0.0 5.8 5 1 1 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG99502.1 - 3.8e-07 30.3 0.0 0.0082 16.4 0.0 3.7 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOG99502.1 - 0.015 14.6 0.3 1.7 7.9 0.0 2.8 2 1 1 3 3 3 0 WD40-like domain WD40 PF00400.32 KOG99503.1 - 1.8e-18 66.5 12.0 0.0015 19.3 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG99503.1 - 5.3e-15 55.5 6.5 1.1e-07 32.1 0.2 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOG99503.1 - 4.7e-07 29.9 0.6 0.006 16.5 0.1 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOG99503.1 - 0.11 11.4 0.1 1.5 7.7 0.0 2.3 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein EMP24_GP25L PF01105.24 KOG99504.1 - 1.4e-48 165.2 1.2 1.6e-48 165.0 1.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF1761 PF08570.10 KOG99504.1 - 0.072 13.3 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1761) DUF4106 PF13388.6 KOG99504.1 - 0.14 11.4 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) 3Beta_HSD PF01073.19 KOG99505.1 - 1.8e-101 338.9 0.0 2.1e-101 338.6 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KOG99505.1 - 1e-31 110.2 0.0 1.4e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOG99505.1 - 5.6e-20 72.0 0.0 2.1e-19 70.1 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 KOG99505.1 - 8.3e-14 51.4 0.0 1.3e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 KOG99505.1 - 3.6e-13 49.3 0.0 4.9e-12 45.6 0.0 2.3 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 KOG99505.1 - 1.7e-11 44.3 0.0 2.4e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 KOG99505.1 - 2.9e-10 39.8 0.0 6e-10 38.7 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 KOG99505.1 - 0.00074 19.5 0.0 0.0099 15.8 0.0 2.2 1 1 0 1 1 1 1 KR domain NmrA PF05368.13 KOG99505.1 - 0.07 12.7 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family SANT_DAMP1_like PF16282.5 KOG99506.1 - 1e-25 89.7 9.7 3.4e-25 88.0 9.7 2.0 1 1 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Myb_DNA-binding PF00249.31 KOG99506.1 - 0.064 13.5 1.4 0.084 13.1 0.1 2.0 2 0 0 2 2 2 0 Myb-like DNA-binding domain DMAP1_like PF17024.5 KOG99506.1 - 0.076 13.1 3.0 0.14 12.3 0.5 2.3 2 0 0 2 2 2 0 Putative DMAP1-like Myb_DNA-bind_6 PF13921.6 KOG99506.1 - 0.26 11.5 5.3 0.11 12.8 1.2 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain Cullin PF00888.22 KOG99507.1 - 1.2e-115 387.5 15.0 1.8e-115 387.0 15.0 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KOG99507.1 - 1e-17 63.9 1.1 5.3e-17 61.6 1.1 2.4 1 0 0 1 1 1 1 Cullin protein neddylation domain Sigma70_r4 PF04545.16 KOG99507.1 - 0.057 13.0 0.0 0.17 11.4 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 PCI PF01399.27 KOG99507.1 - 0.44 11.1 3.2 3.4 8.2 0.1 3.7 3 1 0 3 3 3 0 PCI domain Pex24p PF06398.11 KOG99508.1 - 8.5e-85 284.9 9.6 1.1e-84 284.5 9.6 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin TFIIF_beta_N PF17683.1 KOG99509.1 - 3.1e-36 125.1 8.8 1.8e-35 122.6 8.8 2.2 1 1 0 1 1 1 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 KOG99509.1 - 1.5e-26 92.3 0.9 3.5e-26 91.1 0.9 1.6 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Tau95 PF09734.9 KOG99509.1 - 0.062 14.1 13.6 18 6.1 13.6 2.3 1 1 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain YqaH PF17448.2 KOG99509.1 - 0.11 12.9 1.3 12 6.2 0.1 2.9 1 1 1 2 2 2 0 Uncharacterized YqaH-like GAGA_bind PF06217.12 KOG99509.1 - 0.37 11.0 11.3 0.41 10.9 4.5 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family UPF0242 PF06785.11 KOG99509.1 - 3.2 7.8 14.8 0.51 10.4 8.7 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus E7 PF00527.18 KOG99509.1 - 6 7.1 6.8 27 5.0 6.8 2.2 1 1 0 1 1 1 0 E7 protein, Early protein Prp18 PF02840.15 KOG99510.1 - 3.6e-35 121.1 0.2 1e-34 119.6 0.0 1.8 2 1 0 2 2 2 1 Prp18 domain GnHR_trans PF12369.8 KOG99510.1 - 0.27 12.0 0.4 0.27 12.0 0.4 1.7 2 0 0 2 2 2 0 Gonadotropin hormone receptor transmembrane region CTP_transf_like PF01467.26 KOG99511.1 - 9.4e-33 113.4 0.1 3.8e-24 85.5 0.1 2.1 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 KOG99511.1 - 0.0049 16.8 0.2 6.5 6.6 0.2 3.2 3 0 0 3 3 3 2 FAD synthetase HABP4_PAI-RBP1 PF04774.15 KOG99512.1 - 0.00057 20.7 0.9 0.00065 20.5 0.5 1.4 1 1 0 1 1 1 1 Hyaluronan / mRNA binding family Sharpin_PH PF16764.5 KOG99513.1 - 0.095 12.5 0.4 0.27 11.0 0.1 1.9 2 0 0 2 2 2 0 Sharpin PH domain CTP_transf_like PF01467.26 KOG99514.1 - 3.8e-32 111.4 0.0 5.7e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like PALP PF00291.25 KOG99515.1 - 2.2e-68 230.9 0.4 2.5e-68 230.7 0.4 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme LacAB_rpiB PF02502.18 KOG99515.1 - 1.7 8.6 8.9 0.25 11.3 0.7 3.3 3 2 1 4 4 4 0 Ribose/Galactose Isomerase FOP_dimer PF09398.10 KOG99516.1 - 0.003 17.8 0.0 0.011 15.9 0.0 2.0 1 0 0 1 1 1 1 FOP N terminal dimerisation domain Med30 PF11315.8 KOG99516.1 - 0.077 13.2 12.7 2.4 8.4 0.0 2.9 2 0 0 2 2 2 0 Mediator complex subunit 30 CobS PF02654.15 KOG99516.1 - 0.25 11.5 0.0 0.36 11.0 0.0 1.1 1 0 0 1 1 1 0 Cobalamin-5-phosphate synthase Orf78 PF06024.12 KOG99517.1 - 0.0078 16.5 0.0 0.066 13.5 0.0 2.7 1 0 0 1 1 1 1 Orf78 (ac78) ALS2CR11 PF15729.5 KOG99517.1 - 5.2 6.1 14.5 15 4.6 14.5 1.8 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 Abhydrolase_1 PF00561.20 KOG99518.1 - 3e-26 92.6 0.0 3.5e-26 92.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOG99518.1 - 2.3e-08 34.9 0.0 2.9e-08 34.6 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOG99518.1 - 2e-07 30.6 0.0 3.3e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 KOG99518.1 - 1.1e-06 29.0 0.0 1.7e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 KOG99518.1 - 0.00091 19.0 0.0 0.0025 17.6 0.0 1.7 1 1 0 1 1 1 1 PGAP1-like protein Esterase PF00756.20 KOG99518.1 - 0.0021 17.8 0.0 0.0039 16.9 0.0 1.4 1 0 0 1 1 1 1 Putative esterase FeoB_C PF07664.12 KOG99518.1 - 0.074 12.8 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B C terminus BAAT_C PF08840.11 KOG99518.1 - 0.079 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF2974 PF11187.8 KOG99518.1 - 0.081 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Pyridox_oxase_2 PF12766.7 KOG99520.1 - 1.3e-30 105.9 0.1 1.3e-30 105.9 0.1 1.6 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase GCIP PF13324.6 KOG99520.1 - 5.3 6.6 8.5 8.8 5.8 8.5 1.4 1 1 0 1 1 1 0 Grap2 and cyclin-D-interacting IFT57 PF10498.9 KOG99520.1 - 5.6 5.8 11.0 12 4.8 11.0 1.5 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 Roughex PF06020.11 KOG99520.1 - 7.6 5.5 8.7 4.6 6.2 7.0 1.4 2 0 0 2 2 2 0 Drosophila roughex protein Aminotran_3 PF00202.21 KOG99521.1 - 8.2e-103 344.2 0.0 9.3e-103 344.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III ATP-synt_F PF01990.17 KOG99522.1 - 2.6e-32 111.0 0.3 3e-32 110.8 0.3 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DUF325 PF03804.13 KOG99522.1 - 0.059 13.4 0.1 0.083 12.9 0.1 1.3 1 0 0 1 1 1 0 Viral proteins of unknown function Transcrip_reg PF01709.20 KOG99523.1 - 4.3e-74 248.9 1.3 5.1e-74 248.7 1.3 1.1 1 0 0 1 1 1 1 Transcriptional regulator Mid2 PF04478.12 KOG99524.1 - 3.3e-67 225.0 0.7 3.3e-67 225.0 0.7 3.5 2 1 0 2 2 2 1 Mid2 like cell wall stress sensor SKG6 PF08693.10 KOG99524.1 - 0.0062 15.9 1.0 0.0062 15.9 1.0 3.7 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Thg1 PF04446.12 KOG99525.1 - 5.2e-48 162.2 0.3 7.7e-48 161.6 0.3 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 KOG99525.1 - 2.6e-38 130.9 0.2 5e-38 130.0 0.2 1.4 1 0 0 1 1 1 1 Thg1 C terminal domain Ribosomal_S25 PF03297.15 KOG99527.1 - 2.2e-38 130.5 5.2 2.5e-38 130.3 5.2 1.0 1 0 0 1 1 1 1 S25 ribosomal protein FtsK_gamma PF09397.10 KOG99527.1 - 0.00017 21.3 0.0 0.00024 20.8 0.0 1.3 1 0 0 1 1 1 1 Ftsk gamma domain EAP30 PF04157.16 KOG99527.1 - 0.029 13.7 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family HTH_CodY PF08222.11 KOG99527.1 - 0.075 12.6 0.1 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain AAA PF00004.29 KOG99528.1 - 7.6e-39 133.2 0.0 1.2e-38 132.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG99528.1 - 1.1e-11 44.3 0.1 2.4e-11 43.2 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_14 PF13173.6 KOG99528.1 - 1.2e-06 28.6 0.0 2.8e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOG99528.1 - 1.5e-06 28.2 0.1 2.7e-05 24.2 0.1 2.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KOG99528.1 - 2.5e-06 27.3 0.0 7.6e-06 25.8 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOG99528.1 - 3.2e-06 27.6 0.1 0.00022 21.7 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 KOG99528.1 - 5.4e-06 26.6 0.0 1.1e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOG99528.1 - 4.4e-05 23.8 0.4 0.0038 17.5 0.0 2.9 1 1 2 3 3 3 1 AAA domain AAA_18 PF13238.6 KOG99528.1 - 6.4e-05 23.5 0.0 0.00013 22.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOG99528.1 - 0.00028 21.1 0.0 0.00065 19.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.6 KOG99528.1 - 0.0006 19.9 0.0 0.0013 18.9 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 KOG99528.1 - 0.00067 19.1 0.2 0.0018 17.7 0.2 1.6 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 KOG99528.1 - 0.00068 19.4 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein TniB PF05621.11 KOG99528.1 - 0.00077 18.9 0.0 0.93 8.9 0.0 2.3 1 1 1 2 2 2 2 Bacterial TniB protein RNA_helicase PF00910.22 KOG99528.1 - 0.001 19.4 0.0 0.0023 18.3 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Rad17 PF03215.15 KOG99528.1 - 0.0011 18.9 0.1 0.0047 16.9 0.0 1.9 1 1 0 1 1 1 1 Rad17 P-loop domain DUF815 PF05673.13 KOG99528.1 - 0.0012 18.1 0.0 0.0019 17.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 KOG99528.1 - 0.0029 17.4 0.0 0.0049 16.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 KOG99528.1 - 0.0057 16.6 0.1 0.015 15.2 0.1 1.7 1 0 0 1 1 1 1 NACHT domain AAA_7 PF12775.7 KOG99528.1 - 0.0071 15.9 0.0 0.029 13.9 0.0 2.0 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_17 PF13207.6 KOG99528.1 - 0.0071 16.8 0.0 0.02 15.3 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_28 PF13521.6 KOG99528.1 - 0.0087 16.3 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Bac_DnaA PF00308.18 KOG99528.1 - 0.0091 15.9 0.0 0.021 14.7 0.0 1.5 1 1 0 1 1 1 1 Bacterial dnaA protein Zeta_toxin PF06414.12 KOG99528.1 - 0.0092 15.3 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin TIP49 PF06068.13 KOG99528.1 - 0.0094 15.2 0.1 0.025 13.8 0.1 1.7 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_25 PF13481.6 KOG99528.1 - 0.011 15.3 0.1 0.06 12.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KOG99528.1 - 0.013 16.0 0.0 0.034 14.7 0.0 1.9 1 1 0 1 1 1 0 ABC transporter Hydin_ADK PF17213.3 KOG99528.1 - 0.014 15.7 0.3 0.91 9.8 0.0 2.6 3 0 0 3 3 2 0 Hydin Adenylate kinase-like domain Sigma54_activat PF00158.26 KOG99528.1 - 0.014 15.1 0.0 0.046 13.4 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.11 KOG99528.1 - 0.03 14.2 0.0 0.069 13.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 KOG99528.1 - 0.032 14.2 0.1 0.16 11.9 0.0 2.0 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea TsaE PF02367.17 KOG99528.1 - 0.034 14.2 0.0 0.064 13.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE KAP_NTPase PF07693.14 KOG99528.1 - 0.04 13.2 1.0 1.5 7.9 0.0 2.5 2 1 1 3 3 3 0 KAP family P-loop domain Parvo_NS1 PF01057.17 KOG99528.1 - 0.044 12.9 0.1 0.087 11.9 0.0 1.4 2 0 0 2 2 1 0 Parvovirus non-structural protein NS1 Viral_helicase1 PF01443.18 KOG99528.1 - 0.053 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase tRNA_lig_kinase PF08303.11 KOG99528.1 - 0.15 12.2 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 tRNA ligase kinase domain SKI PF01202.22 KOG99528.1 - 0.18 12.0 0.1 0.63 10.2 0.1 1.9 2 0 0 2 2 2 0 Shikimate kinase IPT PF01745.16 KOG99528.1 - 0.18 11.2 0.0 0.33 10.3 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase Alba PF01918.21 KOG99529.1 - 8.4e-11 41.5 0.0 1.3e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Alba T3SchapCesA PF11439.8 KOG99529.1 - 0.019 15.1 0.9 3.6 7.8 0.1 2.4 2 1 1 3 3 3 0 Type III secretion system filament chaperone CesA Abhydrolase_1 PF00561.20 KOG99530.1 - 2.5e-29 102.7 0.0 3.1e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOG99530.1 - 8.4e-13 49.4 0.0 1.2e-12 48.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOG99530.1 - 1.4e-12 47.4 0.0 1.8e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 KOG99530.1 - 4.4e-07 29.9 0.2 3.6e-05 23.6 0.2 2.3 1 1 0 1 1 1 1 PGAP1-like protein Esterase PF00756.20 KOG99530.1 - 0.00013 21.8 0.0 0.00024 20.8 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Thioesterase PF00975.20 KOG99530.1 - 0.0024 18.0 0.0 0.0046 17.1 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain Palm_thioest PF02089.15 KOG99530.1 - 0.011 15.5 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF676 PF05057.14 KOG99530.1 - 0.014 14.9 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Glucan_synthase PF02364.15 KOG99531.1 - 0 1340.1 0.0 0 1339.5 0.0 1.3 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 KOG99531.1 - 4.4e-41 140.2 0.2 1.9e-40 138.2 0.2 2.2 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 DUF3671 PF12420.8 KOG99531.1 - 0.068 13.3 0.0 0.068 13.3 0.0 3.3 3 1 0 3 3 3 0 Protein of unknown function DUF4179 PF13786.6 KOG99531.1 - 0.13 12.7 0.4 1.4 9.5 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) TIM21 PF08294.11 KOG99532.1 - 9.6e-60 200.7 0.1 1.2e-59 200.3 0.1 1.1 1 0 0 1 1 1 1 TIM21 GxGYxYP_C PF14323.6 KOG99532.1 - 0.084 12.7 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain Ribosomal_L26 PF16906.5 KOG99533.1 - 2.2e-36 124.2 2.1 2.6e-36 123.9 2.1 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 KOG99533.1 - 7.9e-05 22.5 2.0 0.00017 21.4 2.0 1.6 1 0 0 1 1 1 1 KOW motif PAP2 PF01569.21 KOG99535.1 - 4.1e-19 68.7 0.9 4.1e-19 68.7 0.9 1.6 2 0 0 2 2 2 1 PAP2 superfamily DUF212 PF02681.14 KOG99535.1 - 0.12 12.5 0.2 0.57 10.3 0.0 2.0 2 0 0 2 2 2 0 Divergent PAP2 family ACBP PF00887.19 KOG99536.1 - 4.9e-28 97.2 0.8 6.9e-28 96.7 0.8 1.2 1 0 0 1 1 1 1 Acyl CoA binding protein ORMDL PF04061.14 KOG99537.1 - 5.7e-57 191.3 6.4 6.9e-57 191.0 6.4 1.1 1 0 0 1 1 1 1 ORMDL family Pkinase PF00069.25 KOG99538.1 - 4.6e-68 229.4 0.0 5.5e-68 229.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99538.1 - 2.4e-32 112.2 0.1 4.1e-32 111.5 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG99538.1 - 3.4e-05 23.3 0.0 6.9e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOG99538.1 - 0.00045 19.6 0.0 0.00074 18.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOG99538.1 - 0.01 15.8 0.3 0.054 13.4 0.0 2.1 2 1 0 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 KOG99538.1 - 0.052 13.2 0.2 0.12 12.0 0.1 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF2439 PF10382.9 KOG99540.1 - 6.5e-23 80.9 0.8 1.3e-22 80.0 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) DUF4284 PF14112.6 KOG99540.1 - 0.08 13.9 0.1 0.3 12.0 0.1 1.9 1 1 1 2 2 2 0 Immunity protein 22 TAL_FSA PF00923.19 KOG99541.1 - 1.1e-94 317.0 0.2 1.3e-94 316.8 0.2 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase InvH PF04741.12 KOG99541.1 - 0.067 13.1 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 InvH outer membrane lipoprotein zf-C2H2_4 PF13894.6 KOG99542.1 - 4.2e-05 24.0 14.5 0.005 17.6 0.6 4.1 3 1 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KOG99542.1 - 0.00091 19.6 0.6 0.00091 19.6 0.6 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KOG99542.1 - 0.032 14.5 1.8 0.38 11.1 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 KOG99542.1 - 0.075 13.2 1.3 4 7.5 0.3 2.3 1 1 0 2 2 2 0 Aberrant zinc-finger zf-Di19 PF05605.12 KOG99542.1 - 0.079 13.3 4.4 8.8 6.7 0.1 3.4 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 KOG99542.1 - 0.43 11.1 16.7 0.96 10.0 1.4 4.6 4 1 0 4 4 4 0 Zinc-finger double domain Tam41_Mmp37 PF09139.11 KOG99543.1 - 2.4e-90 303.2 7.9 3.3e-83 279.8 1.1 2.2 1 1 1 2 2 2 2 Phosphatidate cytidylyltransferase, mitochondrial TPR_19 PF14559.6 KOG99544.1 - 4e-14 52.9 11.4 0.0053 17.2 0.0 7.4 5 2 3 8 8 8 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOG99544.1 - 4.1e-13 48.4 16.3 0.15 12.2 0.2 10.9 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOG99544.1 - 9.6e-11 41.0 11.8 1.8 8.5 0.0 9.2 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOG99544.1 - 3.2e-10 40.5 11.4 0.002 18.7 0.2 6.7 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOG99544.1 - 3e-09 36.6 8.3 1 9.9 0.0 7.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOG99544.1 - 9.8e-08 31.6 13.5 0.074 13.3 0.2 8.9 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOG99544.1 - 1.3e-07 31.6 0.3 0.012 15.7 0.1 5.4 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOG99544.1 - 2.2e-07 31.0 16.6 0.016 15.4 0.3 6.8 5 3 1 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOG99544.1 - 8.8e-07 29.1 10.2 0.031 14.5 0.1 5.2 3 2 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KOG99544.1 - 3.3e-06 27.4 15.3 0.13 13.0 0.0 7.1 9 0 0 9 9 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOG99544.1 - 2.2e-05 24.9 9.7 34 5.6 0.0 7.7 5 2 3 8 8 7 0 Tetratricopeptide repeat TPR_20 PF14561.6 KOG99544.1 - 0.00015 22.0 0.1 2 8.8 0.0 4.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOG99544.1 - 0.049 13.3 10.8 1.1 9.0 0.1 5.2 4 1 1 5 5 5 0 TPR repeat DUF3273 PF11677.8 KOG99544.1 - 0.14 11.4 0.1 0.32 10.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3273) Alkyl_sulf_dimr PF14863.6 KOG99544.1 - 0.16 12.4 0.8 0.85 10.1 0.1 2.5 3 0 0 3 3 2 0 Alkyl sulfatase dimerisation TPR_10 PF13374.6 KOG99544.1 - 0.25 11.3 6.3 55 3.8 0.1 5.7 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOG99544.1 - 4.4 7.6 10.4 37 4.7 0.1 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat UFD1 PF03152.14 KOG99545.1 - 3.4e-70 235.0 0.0 4.5e-70 234.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Pkinase PF00069.25 KOG99547.1 - 2.2e-46 158.4 0.0 3.7e-46 157.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99547.1 - 8e-26 90.9 0.0 1.9e-25 89.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG99547.1 - 7.6e-07 28.7 0.0 1.6e-06 27.7 0.0 1.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KOG99547.1 - 0.00018 21.5 0.0 0.61 10.0 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family WYL_3 PF18488.1 KOG99547.1 - 0.071 13.5 0.0 0.59 10.5 0.0 2.5 2 0 0 2 2 2 0 WYL domain MMU163 PF17119.5 KOG99548.1 - 6.2e-20 71.4 1.2 6.4e-19 68.1 1.2 2.0 1 1 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis eIF2A PF08662.11 KOG99549.1 - 8.6e-76 254.1 0.1 3.2e-75 252.3 0.0 2.0 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 KOG99549.1 - 0.0015 19.3 2.5 2.7 9.0 0.1 4.6 3 2 1 4 4 4 2 WD domain, G-beta repeat AA_permease_2 PF13520.6 KOG99550.1 - 6.8e-82 275.6 46.5 8.6e-82 275.2 46.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOG99550.1 - 2.9e-15 55.9 44.4 5.6e-15 54.9 44.4 1.4 1 1 0 1 1 1 1 Amino acid permease Bromodomain PF00439.25 KOG99551.1 - 1.8e-30 104.8 11.4 6.7e-15 54.9 1.1 3.1 3 0 0 3 3 3 2 Bromodomain BAH PF01426.18 KOG99551.1 - 5.2e-28 97.3 0.1 1.1e-27 96.3 0.1 1.6 1 0 0 1 1 1 1 BAH domain CENP-B_dimeris PF09026.10 KOG99551.1 - 0.15 12.4 6.8 0.4 11.1 6.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Folliculin PF11704.8 KOG99552.1 - 7.5e-43 146.6 0.4 1e-42 146.1 0.4 1.2 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport DUF2321 PF10083.9 KOG99552.1 - 0.054 13.1 0.0 0.082 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) EF-hand_7 PF13499.6 KOG99553.1 - 1.8e-09 37.9 0.7 0.00016 22.1 0.0 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOG99553.1 - 6.2e-07 28.8 2.2 0.053 13.5 0.1 4.3 3 1 1 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 KOG99553.1 - 0.00016 21.0 0.1 9.2 6.1 0.0 4.7 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 KOG99553.1 - 0.00037 20.3 0.3 2.9 7.8 0.0 4.1 3 2 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 KOG99553.1 - 0.0088 15.5 0.2 8.8 6.0 0.0 3.6 3 0 0 3 3 3 2 EF hand Septin PF00735.18 KOG99554.1 - 2e-99 332.5 2.0 2e-99 332.5 2.0 1.8 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 KOG99554.1 - 0.00013 22.0 0.1 0.00049 20.2 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG99554.1 - 0.00053 19.9 5.0 0.0026 17.7 0.4 3.3 3 1 0 3 3 3 1 RsgA GTPase CCDC92 PF14916.6 KOG99554.1 - 0.04 13.7 4.2 0.11 12.3 4.2 1.8 1 0 0 1 1 1 0 Coiled-coil domain of unknown function S6PP PF05116.13 KOG99554.1 - 0.044 13.3 0.8 0.08 12.5 0.8 1.3 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase AAA_16 PF13191.6 KOG99554.1 - 0.19 12.1 0.0 0.44 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 KOG99554.1 - 0.2 12.1 2.5 3 8.3 0.0 3.0 3 0 0 3 3 3 0 RNA helicase GTP_EFTU PF00009.27 KOG99554.1 - 1.3 8.5 4.3 11 5.5 0.1 3.1 2 2 0 2 2 2 0 Elongation factor Tu GTP binding domain FA_hydroxylase PF04116.13 KOG99555.1 - 2.9e-26 92.4 21.1 2.9e-26 92.4 21.1 2.2 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily GATase_5 PF13507.6 KOG99556.1 - 1e-99 332.9 0.0 1.5e-99 332.3 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 KOG99556.1 - 1.7e-44 151.7 0.1 6e-31 107.7 0.0 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 KOG99556.1 - 5.9e-28 97.2 0.0 1.1e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 KOG99556.1 - 1.5e-21 76.6 0.0 5.1e-21 75.0 0.0 2.0 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain 60KD_IMP PF02096.20 KOG99557.1 - 1.2e-09 38.2 10.2 1.7e-09 37.8 3.0 2.2 2 0 0 2 2 2 2 60Kd inner membrane protein Spt4 PF06093.13 KOG99558.1 - 6.3e-29 99.9 0.6 7.4e-29 99.7 0.6 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger TackOD1 PF18551.1 KOG99558.1 - 0.062 13.0 1.2 0.084 12.5 1.2 1.2 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 MFS_1 PF07690.16 KOG99559.1 - 1.6e-20 73.3 22.2 4.1e-19 68.7 20.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Vac_ImportDeg PF09783.9 KOG99560.1 - 6.3e-47 159.4 0.4 8.2e-47 159.0 0.4 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein zf-C2H2 PF00096.26 KOG99561.1 - 2.7e-07 30.7 13.2 5.5e-05 23.4 2.4 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG99561.1 - 4.4e-05 24.0 11.8 0.015 16.1 2.3 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOG99561.1 - 0.00044 20.6 1.3 0.00044 20.6 1.3 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-MYST PF17772.1 KOG99561.1 - 0.097 12.3 0.1 0.36 10.5 0.1 1.9 1 0 0 1 1 1 0 MYST family zinc finger domain Arrestin_C PF02752.22 KOG99562.1 - 4.4e-19 69.3 0.3 1.1e-18 68.0 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 KOG99562.1 - 0.00012 22.2 0.0 0.0059 16.7 0.0 2.5 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain CNH PF00780.22 KOG99563.1 - 9.6e-59 199.2 1.2 1.8e-58 198.4 1.2 1.4 1 0 0 1 1 1 1 CNH domain PH_5 PF15405.6 KOG99563.1 - 9.1e-37 126.2 0.1 9.1e-37 126.2 0.1 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain RhoGEF PF00621.20 KOG99563.1 - 2.2e-26 93.2 0.2 2.2e-26 93.2 0.2 2.2 3 0 0 3 3 3 1 RhoGEF domain DEP PF00610.21 KOG99563.1 - 1.1e-10 41.4 0.0 3e-10 40.0 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) zf-BED PF02892.15 KOG99564.1 - 5.6e-10 39.1 1.3 1.2e-09 38.0 1.3 1.6 1 0 0 1 1 1 1 BED zinc finger RSS_P20 PF11757.8 KOG99564.1 - 0.1 13.1 2.4 0.98 9.9 2.3 2.9 1 1 0 1 1 1 0 Suppressor of RNA silencing P21-like N-terminal domain Smg4_UPF3 PF03467.15 KOG99565.1 - 6e-30 104.5 25.1 6e-30 104.5 25.1 3.5 2 1 0 2 2 2 1 Smg-4/UPF3 family DUF4278 PF14105.6 KOG99565.1 - 0.052 14.0 0.4 0.2 12.1 0.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4278) LSM PF01423.22 KOG99566.1 - 1.4e-25 88.8 0.1 2e-25 88.2 0.1 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KOG99566.1 - 0.0025 17.9 0.0 0.0037 17.4 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF148 PF02520.17 KOG99566.1 - 0.023 14.8 0.1 0.039 14.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF148 PRP38 PF03371.15 KOG99567.1 - 3e-41 141.2 2.6 3.5e-41 141.0 2.6 1.0 1 0 0 1 1 1 1 PRP38 family Mitoc_mL59 PF18126.1 KOG99568.1 - 9.1e-27 93.9 0.6 1.3e-26 93.5 0.2 1.4 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 Prefoldin PF02996.17 KOG99570.1 - 1.8e-36 124.7 0.2 2.8e-36 124.0 0.2 1.3 1 0 0 1 1 1 1 Prefoldin subunit Pox_A_type_inc PF04508.12 KOG99570.1 - 0.088 12.7 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat DUF1147 PF06615.11 KOG99570.1 - 0.17 11.9 0.2 2 8.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1147) Lebercilin PF15619.6 KOG99570.1 - 0.2 11.3 5.2 2.8 7.6 1.8 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Prefoldin_2 PF01920.20 KOG99570.1 - 0.2 11.6 7.5 0.25 11.3 0.1 2.5 3 0 0 3 3 3 0 Prefoldin subunit TSC22 PF01166.18 KOG99570.1 - 0.27 11.6 1.7 4 7.8 0.9 2.6 2 1 0 2 2 2 0 TSC-22/dip/bun family CC2-LZ PF16516.5 KOG99570.1 - 0.34 11.3 4.2 0.3 11.5 0.5 2.4 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator MtrF PF09472.10 KOG99571.1 - 0.064 12.7 0.0 0.22 10.9 0.0 1.8 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Cofilin_ADF PF00241.20 KOG99572.1 - 3.1e-27 94.8 0.2 2.7e-12 46.6 0.1 2.4 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Med25 PF11232.8 KOG99572.1 - 0.81 9.7 3.3 13 5.7 0.0 2.9 3 0 0 3 3 3 0 Mediator complex subunit 25 PTOV activation and synapsin 2 SLX9 PF15341.6 KOG99573.1 - 9e-23 81.1 11.1 1.3e-22 80.6 11.1 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 MAS20 PF02064.15 KOG99574.1 - 1.8e-37 128.3 1.4 2.2e-37 128.0 1.4 1.1 1 0 0 1 1 1 1 MAS20 protein import receptor IF-2B PF01008.17 KOG99575.1 - 7.6e-111 369.8 0.0 7.6e-111 369.8 0.0 2.1 2 0 0 2 2 2 1 Initiation factor 2 subunit family CobN-Mg_chel PF02514.16 KOG99575.1 - 0.036 11.8 8.4 0.03 12.1 6.7 1.5 2 0 0 2 2 2 0 CobN/Magnesium Chelatase STb_secrete PF09075.10 KOG99575.1 - 0.037 14.1 0.1 0.28 11.3 0.1 2.2 2 0 0 2 2 2 0 Heat-stable enterotoxin B, secretory Membralin PF09746.9 KOG99575.1 - 1.7 7.6 6.1 3.5 6.6 6.1 1.4 1 0 0 1 1 1 0 Tumour-associated protein DUF4407 PF14362.6 KOG99575.1 - 4.1 6.7 14.5 9 5.5 14.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ribosomal_L5_C PF00673.21 KOG99577.1 - 1.8e-22 79.3 0.0 3e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 KOG99577.1 - 2.4e-19 69.4 0.1 7.4e-19 67.8 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L5 Pil1 PF13805.6 KOG99578.1 - 2.9e-123 410.5 0.0 3.6e-123 410.2 0.0 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 SLT_beta PF02258.16 KOG99578.1 - 0.18 11.8 0.0 0.53 10.3 0.0 1.7 1 0 0 1 1 1 0 Shiga-like toxin beta subunit TPP_enzyme_N PF02776.18 KOG99579.1 - 1.3e-30 106.3 0.0 2e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 KOG99579.1 - 1.2e-25 89.9 0.0 7.1e-25 87.3 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 KOG99579.1 - 2.6e-14 53.3 0.0 5.6e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Catalase PF00199.19 KOG99581.1 - 7.6e-167 555.2 0.3 1e-166 554.8 0.3 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 KOG99581.1 - 1.8e-11 44.1 0.1 9.5e-11 41.8 0.0 2.3 3 0 0 3 3 3 1 Catalase-related immune-responsive DivIC PF04977.15 KOG99582.1 - 0.00042 20.0 1.8 0.00042 20.0 1.8 4.9 5 0 0 5 5 5 1 Septum formation initiator NPM1-C PF16276.5 KOG99582.1 - 0.003 17.5 5.2 0.16 11.9 0.0 3.9 3 0 0 3 3 3 2 Nucleophosmin C-terminal domain DUF1664 PF07889.12 KOG99582.1 - 0.13 12.3 17.5 0.23 11.5 6.7 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) RasGAP_C PF03836.15 KOG99582.1 - 0.22 11.7 30.9 0.11 12.7 7.5 3.8 1 1 2 3 3 3 0 RasGAP C-terminus Laminin_II PF06009.12 KOG99582.1 - 0.3 11.1 21.2 3.7 7.6 9.6 2.8 1 1 1 2 2 2 0 Laminin Domain II SpecificRecomb PF10136.9 KOG99582.1 - 0.58 8.4 7.8 0.094 11.0 0.5 2.2 2 0 0 2 2 2 0 Site-specific recombinase Cluap1 PF10234.9 KOG99582.1 - 2 7.7 26.9 6.7 6.0 25.1 2.3 1 1 1 2 2 2 0 Clusterin-associated protein-1 Nrap_D5 PF17406.2 KOG99583.1 - 1.7e-51 174.2 0.0 3.5e-51 173.2 0.0 1.6 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D2 PF17403.2 KOG99583.1 - 1.7e-49 167.5 1.8 1.9e-48 164.1 0.8 2.6 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain Nrap_D4 PF17405.2 KOG99583.1 - 2.9e-48 164.0 0.1 5.6e-48 163.1 0.1 1.5 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap PF03813.14 KOG99583.1 - 2.5e-44 151.0 3.3 5.6e-44 149.9 3.3 1.6 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D3 PF17404.2 KOG99583.1 - 1.7e-40 138.7 0.0 3.4e-40 137.7 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 KOG99583.1 - 4.7e-28 98.1 0.1 1.5e-27 96.5 0.1 1.9 1 0 0 1 1 1 1 Nrap protein domain 6 Nop PF01798.18 KOG99584.1 - 4e-62 209.7 0.0 6.7e-62 209.0 0.0 1.4 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 KOG99584.1 - 1.8e-26 93.4 1.4 3.6e-26 92.4 1.4 1.5 1 0 0 1 1 1 1 Prp31 C terminal domain Pkinase PF00069.25 KOG99585.1 - 5.8e-57 193.1 0.0 3.3e-56 190.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99585.1 - 6.4e-28 97.7 0.5 2.7e-19 69.5 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 KOG99585.1 - 0.00019 22.0 1.4 0.00085 20.0 1.4 2.1 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 KOG99585.1 - 0.0031 16.5 0.8 0.017 14.1 0.7 1.9 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOG99585.1 - 0.0043 16.4 0.0 0.0097 15.3 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOG99585.1 - 0.0094 15.3 0.0 0.075 12.3 0.0 2.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KOG99585.1 - 0.42 10.5 3.3 0.84 9.5 1.2 2.7 3 1 0 3 3 3 0 Phosphotransferase enzyme family CwfJ_C_1 PF04677.15 KOG99586.1 - 2.9e-37 127.3 0.2 7e-37 126.0 0.2 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 KOG99586.1 - 1.5e-15 57.8 0.6 7.1e-15 55.7 0.6 2.2 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 tRNA-synt_1 PF00133.22 KOG99587.1 - 1.4e-238 793.1 0.1 1.7e-237 789.5 0.1 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KOG99587.1 - 1.1e-30 106.6 2.4 3.2e-30 105.1 2.4 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KOG99587.1 - 2e-15 56.5 0.5 9e-09 34.5 0.0 4.2 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 KOG99587.1 - 1.6e-07 31.0 0.1 3e-06 26.9 0.0 3.6 3 1 1 4 4 4 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 KOG99587.1 - 0.00073 19.8 6.1 0.00073 19.8 6.1 3.0 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1e PF01406.19 KOG99587.1 - 0.0043 16.5 4.1 0.4 10.0 0.0 3.3 4 1 0 4 4 4 2 tRNA synthetases class I (C) catalytic domain Lzipper-MIP1 PF14389.6 KOG99587.1 - 0.12 12.7 1.1 0.3 11.4 1.1 1.6 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 DUF3450 PF11932.8 KOG99587.1 - 0.17 11.2 8.1 1.8 7.8 3.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF3807 PF12720.7 KOG99587.1 - 0.21 11.8 5.0 0.88 9.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) tRNA-synt_1b PF00579.25 KOG99587.1 - 0.54 9.5 4.0 1.1 8.5 0.0 3.0 3 0 0 3 3 3 0 tRNA synthetases class I (W and Y) RNase_PH PF01138.21 KOG99588.1 - 1.5e-18 67.6 0.0 2.3e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KOG99588.1 - 1.6e-07 31.2 1.3 2.9e-07 30.4 0.2 1.9 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Mito_carr PF00153.27 KOG99589.1 - 3.5e-61 203.1 4.1 3.4e-21 75.0 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOG99589.1 - 0.00078 18.7 0.1 0.33 10.0 0.0 3.1 3 0 0 3 3 3 2 Gammaproteobacterial serine protease PH PF00169.29 KOG99590.1 - 0.0096 16.4 0.2 0.076 13.5 0.0 2.6 3 0 0 3 3 3 1 PH domain Peptidase_C50 PF03568.17 KOG99591.1 - 3.1e-134 448.0 0.1 6.9e-134 446.9 0.1 1.7 1 0 0 1 1 1 1 Peptidase family C50 P_gingi_FimA PF06321.11 KOG99591.1 - 0.23 11.6 1.3 1.1 9.3 0.0 2.6 3 0 0 3 3 3 0 Major fimbrial subunit protein (FimA) Telomere_reg-2 PF10193.9 KOG99592.1 - 1.8e-21 76.6 0.7 4.6e-21 75.3 0.2 2.0 2 0 0 2 2 2 1 Telomere length regulation protein Ada3 PF10198.9 KOG99592.1 - 0.0038 17.4 0.3 0.019 15.1 0.1 2.3 2 1 0 2 2 2 1 Histone acetyltransferases subunit 3 RabGAP-TBC PF00566.18 KOG99593.1 - 7.7e-52 176.1 0.4 7.7e-52 176.1 0.4 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GRAM PF02893.20 KOG99593.1 - 6.8e-20 71.1 0.1 1.6e-19 69.9 0.1 1.7 1 0 0 1 1 1 1 GRAM domain EF-hand_6 PF13405.6 KOG99593.1 - 1.1e-06 28.1 0.9 0.00027 20.6 0.1 3.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOG99593.1 - 3e-05 24.4 0.4 0.0016 18.9 0.3 3.4 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.32 KOG99593.1 - 0.0018 17.7 0.0 0.0056 16.1 0.0 2.0 1 0 0 1 1 1 1 EF hand DUF2252 PF10009.9 KOG99593.1 - 0.093 11.8 2.8 0.29 10.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) Rhomboid PF01694.22 KOG99594.1 - 2.1e-32 112.2 16.9 2.1e-32 112.2 16.9 1.7 2 0 0 2 2 2 1 Rhomboid family Pescadillo_N PF06732.11 KOG99596.1 - 3.5e-124 413.8 0.9 3.5e-124 413.8 0.9 2.5 3 0 0 3 3 3 1 Pescadillo N-terminus BRCT_2 PF16589.5 KOG99596.1 - 1.6e-10 41.3 0.0 9.6e-10 38.7 0.0 2.4 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 KOG99596.1 - 0.00081 19.7 0.1 0.0094 16.3 0.0 2.5 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 KOG99596.1 - 0.12 12.7 0.0 0.64 10.4 0.0 2.3 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain Dockerin_1 PF00404.18 KOG99596.1 - 0.14 12.4 0.1 0.33 11.2 0.1 1.6 1 0 0 1 1 1 0 Dockerin type I domain Med18 PF09637.10 KOG99597.1 - 8.2e-52 176.5 0.3 5.3e-50 170.6 0.3 2.0 1 1 0 1 1 1 1 Med18 protein VMA21 PF09446.10 KOG99598.1 - 4.4e-10 39.5 17.5 4.1e-09 36.4 17.5 1.9 1 1 0 1 1 1 1 VMA21-like domain DAD PF02109.16 KOG99598.1 - 0.011 16.0 0.6 0.012 15.9 0.6 1.1 1 0 0 1 1 1 0 DAD family Syndecan PF01034.20 KOG99598.1 - 4.1 7.4 5.8 0.45 10.5 0.4 1.9 1 1 1 2 2 2 0 Syndecan domain ATP-synt_S1 PF05827.12 KOG99599.1 - 0.0036 17.1 0.5 0.0072 16.2 0.5 1.4 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) DUF4064 PF13273.6 KOG99599.1 - 2.9 8.2 6.9 0.74 10.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Cyclin_N PF00134.23 KOG99600.1 - 4.4e-40 136.4 0.1 2e-39 134.3 0.1 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOG99600.1 - 2.4e-29 101.8 0.2 1.2e-28 99.6 0.0 2.1 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 KOG99601.1 - 1e-41 141.6 2.2 9.8e-39 132.0 1.4 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOG99601.1 - 1.2e-20 73.7 0.0 2.7e-20 72.6 0.0 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain Abhydrolase_1 PF00561.20 KOG99602.1 - 3.3e-31 108.8 0.3 4.2e-31 108.5 0.3 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOG99602.1 - 3.1e-15 57.4 0.0 5.1e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOG99602.1 - 2.4e-10 40.1 0.0 6.1e-10 38.8 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 KOG99602.1 - 0.00069 19.5 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase LIDHydrolase PF10230.9 KOG99602.1 - 0.035 13.6 0.0 0.097 12.2 0.0 1.7 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Acetyltransf_7 PF13508.7 KOG99603.1 - 0.0016 18.8 0.0 0.0029 18.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TLD PF07534.16 KOG99603.1 - 0.01 16.0 0.1 0.029 14.6 0.1 1.7 1 0 0 1 1 1 0 TLD Acetyltransf_9 PF13527.7 KOG99603.1 - 0.072 13.2 0.0 0.36 10.9 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain SURF1 PF02104.15 KOG99604.1 - 9.7e-43 146.4 0.0 1.4e-42 145.9 0.0 1.2 1 0 0 1 1 1 1 SURF1 family DASH_Dam1 PF08653.10 KOG99605.1 - 5e-24 83.9 0.2 5e-24 83.9 0.2 2.3 3 0 0 3 3 3 1 DASH complex subunit Dam1 DUF3246 PF11596.8 KOG99605.1 - 0.033 13.6 0.4 0.052 13.0 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Suppressor_APC PF11414.8 KOG99605.1 - 0.033 14.2 0.6 0.11 12.5 0.3 2.0 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein YqgF PF14639.6 KOG99606.1 - 6.4e-69 230.5 0.0 2e-68 228.9 0.0 1.9 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 SH2_2 PF14633.6 KOG99606.1 - 8.8e-69 231.2 1.9 3e-68 229.5 1.9 2.0 1 0 0 1 1 1 1 SH2 domain HHH_7 PF14635.6 KOG99606.1 - 2.8e-49 165.8 0.2 9e-49 164.2 0.2 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.6 KOG99606.1 - 5.3e-36 123.6 2.1 5.3e-36 123.6 2.1 2.6 2 0 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 KOG99606.1 - 5.1e-20 71.9 22.7 5.1e-20 71.9 22.7 5.8 5 1 1 6 6 6 1 Acidic N-terminal SPT6 SH2 PF00017.24 KOG99606.1 - 5.6e-14 52.0 0.1 2.1e-13 50.1 0.1 2.1 1 0 0 1 1 1 1 SH2 domain HHH_9 PF17674.1 KOG99606.1 - 0.00054 20.8 0.2 0.00054 20.8 0.2 3.6 3 0 0 3 3 3 1 HHH domain Tex_YqgF PF16921.5 KOG99606.1 - 0.12 12.8 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 Tex protein YqgF-like domain DUF3417 PF11897.8 KOG99606.1 - 0.22 12.0 5.2 5.1 7.6 0.2 4.4 3 1 1 4 4 4 0 Protein of unknown function (DUF3417) RGS PF00615.19 KOG99606.1 - 0.93 9.8 6.1 2.5 8.4 1.9 3.2 2 0 0 2 2 2 0 Regulator of G protein signaling domain LisH PF08513.11 KOG99607.1 - 0.0052 16.7 0.0 0.013 15.5 0.0 1.7 1 0 0 1 1 1 1 LisH CNH PF00780.22 KOG99607.1 - 0.012 15.2 0.1 0.11 12.0 0.0 2.2 2 0 0 2 2 2 0 CNH domain WD40 PF00400.32 KOG99607.1 - 0.14 13.1 0.1 33 5.6 0.0 3.3 2 0 0 2 2 2 0 WD domain, G-beta repeat Ribosom_S12_S23 PF00164.25 KOG99608.1 - 1.8e-51 172.5 0.3 2.3e-51 172.2 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Nup54 PF13874.6 KOG99609.1 - 3.8e-35 121.0 4.9 3.8e-35 121.0 4.9 2.6 3 0 0 3 3 3 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 KOG99609.1 - 5.3e-13 49.6 111.4 4e-08 34.0 25.6 4.6 1 1 3 4 4 4 4 Nucleoporin FG repeat region COG2 PF06148.11 KOG99610.1 - 4.7e-09 36.4 4.8 8.3e-09 35.6 3.1 2.1 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Syntaxin_2 PF14523.6 KOG99610.1 - 0.0023 18.3 6.1 0.65 10.4 2.8 3.1 3 1 0 3 3 3 2 Syntaxin-like protein PhaP_Bmeg PF09602.10 KOG99610.1 - 0.042 13.8 5.1 0.13 12.2 5.1 1.8 1 1 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) COX5A PF02284.16 KOG99610.1 - 0.045 13.8 0.0 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 Cytochrome c oxidase subunit Va Spore_III_AB PF09548.10 KOG99610.1 - 0.054 13.6 0.6 0.12 12.4 0.5 1.7 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) zf-C3HC PF07967.13 KOG99610.1 - 0.068 13.2 0.4 0.23 11.5 0.2 1.9 1 1 1 2 2 2 0 C3HC zinc finger-like DUF948 PF06103.11 KOG99610.1 - 0.11 12.7 1.1 0.5 10.7 1.1 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DHR10 PF18595.1 KOG99610.1 - 0.36 10.9 3.0 0.21 11.6 0.9 1.7 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain RecG_N PF17190.4 KOG99610.1 - 0.69 10.7 7.6 5.5 7.8 2.8 2.9 1 1 2 3 3 3 0 RecG N-terminal helical domain Ammonium_transp PF00909.21 KOG99611.1 - 3e-127 424.6 22.8 3.5e-127 424.4 22.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3180 PF11377.8 KOG99611.1 - 0.028 14.6 12.5 0.15 12.2 1.5 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3180) Phage_holin_2_1 PF04971.12 KOG99611.1 - 0.051 13.6 0.2 0.051 13.6 0.2 3.1 3 0 0 3 3 3 0 Bacteriophage P21 holin S Slp PF03843.13 KOG99611.1 - 0.16 11.3 0.1 0.28 10.6 0.1 1.2 1 0 0 1 1 1 0 Outer membrane lipoprotein Slp family DUF5355 PF17306.2 KOG99612.1 - 9.1e-104 347.0 10.2 1.1e-103 346.7 10.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5355) Metallophos PF00149.28 KOG99613.1 - 3.8e-34 119.0 0.1 6.4e-34 118.2 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 KOG99613.1 - 1e-25 89.8 0.2 2.8e-24 85.2 0.0 2.4 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_2 PF07719.17 KOG99613.1 - 7e-15 53.9 1.2 3.2e-05 23.7 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOG99613.1 - 1.5e-13 49.9 1.8 3.7e-06 26.5 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOG99613.1 - 9e-09 34.9 0.0 0.00038 20.1 0.0 2.6 2 0 0 2 2 2 2 TPR repeat TPR_9 PF13371.6 KOG99613.1 - 6.4e-05 23.0 0.0 0.016 15.4 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOG99613.1 - 0.00026 21.5 0.2 0.00094 19.7 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOG99613.1 - 0.00032 20.7 0.5 0.02 15.0 0.0 2.9 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 KOG99613.1 - 0.00064 19.7 1.8 2.4 8.6 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOG99613.1 - 0.0012 19.1 0.2 0.61 10.6 0.1 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Asn_synthase PF00733.21 KOG99614.1 - 8.6e-93 311.8 0.5 9.1e-55 186.7 0.1 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 KOG99614.1 - 2e-33 114.9 0.0 3.2e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 KOG99614.1 - 2.6e-26 92.4 0.0 6.3e-26 91.2 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 KOG99614.1 - 8.3e-08 32.0 0.0 1.6e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 KOG99614.1 - 0.0074 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 NAD synthase Sulfate_transp PF00916.20 KOG99615.1 - 1e-89 301.0 23.9 1.7e-89 300.3 23.9 1.3 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 KOG99615.1 - 2e-16 59.7 1.3 4.1e-16 58.7 1.3 1.6 1 0 0 1 1 1 1 STAS domain cNMP_binding PF00027.29 KOG99615.1 - 0.0035 17.4 0.0 0.0061 16.6 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HAS-barrel PF09378.10 KOG99615.1 - 0.12 12.6 0.6 3.9 7.7 0.2 3.1 3 0 0 3 3 3 0 HAS barrel domain TANGO2 PF05742.12 KOG99617.1 - 8.3e-63 212.8 0.0 9.5e-63 212.6 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 Utp8 PF10395.9 KOG99618.1 - 5.4e-233 775.5 28.7 6.3e-233 775.2 28.7 1.0 1 0 0 1 1 1 1 Utp8 family SYF2 PF08231.12 KOG99619.1 - 3.6e-13 50.2 15.6 3.6e-13 50.2 15.6 1.5 2 0 0 2 2 2 1 SYF2 splicing factor MtrE PF04206.12 KOG99620.1 - 0.27 10.5 0.6 0.45 9.8 0.6 1.2 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit E HSBP1 PF06825.12 KOG99620.1 - 2.1 8.3 15.2 0.64 9.9 0.4 4.4 4 0 0 4 4 4 0 Heat shock factor binding protein 1 MARVEL PF01284.23 KOG99621.1 - 6e-27 94.4 14.2 7.5e-27 94.1 14.2 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF3844 PF12955.7 KOG99621.1 - 0.062 13.4 0.3 0.062 13.4 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3844) DUF1218 PF06749.12 KOG99621.1 - 0.39 11.3 7.0 0.1 13.1 2.5 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1218) Band_7 PF01145.25 KOG99622.1 - 7.2e-24 84.8 5.5 1.5e-23 83.8 5.5 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 KOG99622.1 - 0.001 18.2 1.2 0.0013 17.8 1.2 1.2 1 0 0 1 1 1 1 SigmaW regulon antibacterial Band_7_1 PF13421.6 KOG99622.1 - 0.0062 16.3 0.1 0.01 15.6 0.1 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family UQ_con PF00179.26 KOG99623.1 - 1.5e-36 125.1 0.0 1.7e-36 125.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 KOG99623.1 - 0.0017 18.0 0.0 0.0027 17.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 KOG99623.1 - 0.046 14.0 0.1 0.062 13.6 0.1 1.4 1 1 0 1 1 1 0 RWD domain Proteasome PF00227.26 KOG99625.1 - 5e-58 195.7 0.6 6.2e-58 195.4 0.6 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOG99625.1 - 4.7e-12 45.4 1.2 8.4e-12 44.5 0.2 2.1 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature Nitrate_red_gam PF02665.14 KOG99625.1 - 0.22 11.0 0.0 0.33 10.4 0.0 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit SH3_1 PF00018.28 KOG99626.1 - 1.3e-15 56.8 0.0 2.5e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KOG99626.1 - 6.5e-12 44.9 0.0 1.6e-10 40.5 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 KOG99626.1 - 4.2e-10 39.3 0.0 6.9e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Pro-rich PF15240.6 KOG99626.1 - 0.018 15.4 31.8 0.022 15.1 31.8 1.2 1 0 0 1 1 1 0 Proline-rich TFIIA PF03153.13 KOG99626.1 - 1.6 8.6 11.0 1.8 8.4 11.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MFS_1 PF07690.16 KOG99627.1 - 1.2e-32 113.2 32.5 1.2e-32 113.2 32.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOG99627.1 - 2.1e-14 53.3 9.5 2.1e-14 53.3 9.5 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter TRI5 PF06330.11 KOG99628.1 - 0.1 11.4 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) NDC10_II PF16787.5 KOG99629.1 - 1.3e-111 372.7 4.6 2.4e-111 371.8 4.6 1.4 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 KOG99629.1 - 1.2e-16 60.8 0.1 3.1e-16 59.4 0.1 1.8 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes TAFH PF07531.14 KOG99629.1 - 0.065 13.3 3.0 5.6 7.1 0.2 2.6 2 0 0 2 2 2 0 NHR1 homology to TAF KIND PF16474.5 KOG99629.1 - 0.098 12.5 3.8 0.5 10.2 0.0 2.7 3 0 0 3 3 3 0 Kinase non-catalytic C-lobe domain Vps62 PF06101.11 KOG99630.1 - 3.1e-06 25.8 1.7 9.8e-06 24.1 1.2 1.9 2 0 0 2 2 2 1 Vacuolar protein sorting-associated protein 62 CagE_TrbE_VirB PF03135.14 KOG99630.1 - 0.17 12.0 0.0 13 5.8 0.0 2.1 2 0 0 2 2 2 0 CagE, TrbE, VirB family, component of type IV transporter system GAGA_bind PF06217.12 KOG99631.1 - 1.3 9.3 15.7 0.16 12.3 11.5 1.7 2 0 0 2 2 2 0 GAGA binding protein-like family V_ATPase_I PF01496.19 KOG99631.1 - 2 6.2 13.5 2.5 5.9 13.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF763 PF05559.11 KOG99631.1 - 2.8 7.0 7.6 4.3 6.4 7.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF763) SKN1 PF03935.15 KOG99632.1 - 7.1e-252 836.2 6.1 9.9e-252 835.7 6.1 1.2 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Thi4 PF01946.17 KOG99633.1 - 1.7e-115 384.2 0.1 2.1e-115 383.9 0.1 1.0 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 KOG99633.1 - 3.9e-07 30.0 0.4 8.2e-07 28.9 0.3 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOG99633.1 - 9.7e-06 25.7 0.1 3.3e-05 24.0 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOG99633.1 - 1e-05 24.8 1.1 0.00024 20.3 0.6 2.1 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 KOG99633.1 - 2e-05 23.8 0.2 3.4e-05 23.1 0.2 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 KOG99633.1 - 0.00012 21.6 0.1 0.00017 21.0 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 KOG99633.1 - 0.0014 18.6 0.1 0.0069 16.4 0.1 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 KOG99633.1 - 0.0016 17.2 0.0 0.0056 15.4 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 KOG99633.1 - 0.0041 16.4 0.0 0.0051 16.1 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOG99633.1 - 0.0045 16.3 0.0 0.01 15.1 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOG99633.1 - 0.012 14.7 0.1 0.052 12.6 0.1 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A K_oxygenase PF13434.6 KOG99633.1 - 0.056 12.6 0.0 0.082 12.0 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 KOG99633.1 - 0.11 11.3 0.1 0.15 10.8 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_3 PF01494.19 KOG99633.1 - 0.12 11.6 0.1 0.17 11.1 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain EF_assoc_1 PF08355.12 KOG99633.1 - 0.17 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 EF hand associated NUC153 PF08159.12 KOG99634.1 - 9.5e-11 41.3 4.6 1.9e-10 40.3 4.6 1.6 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 KOG99634.1 - 0.0065 17.3 0.5 15 6.6 0.0 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat Ecl1 PF12855.7 KOG99635.1 - 4.4e-07 31.2 12.8 0.00017 22.8 9.0 2.3 2 1 0 2 2 2 2 ECL1/2/3 zinc binding proteins zf_PR_Knuckle PF18445.1 KOG99635.1 - 0.022 14.5 0.6 0.043 13.6 0.1 1.7 2 0 0 2 2 2 0 PR zinc knuckle motif DUF1279 PF06916.13 KOG99637.1 - 2.5e-21 76.0 0.0 5.1e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Ribosomal_L24e PF01246.20 KOG99638.1 - 8.5e-29 99.6 0.3 8.5e-29 99.6 0.3 1.9 2 0 0 2 2 2 1 Ribosomal protein L24e DUF2838 PF10998.8 KOG99639.1 - 6.7e-43 145.4 16.9 6.7e-43 145.4 16.9 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF2838) PPR_2 PF13041.6 KOG99640.1 - 4.6e-14 52.3 2.2 2.2e-09 37.4 0.1 4.2 4 0 0 4 4 4 2 PPR repeat family PPR PF01535.20 KOG99640.1 - 1.8e-06 27.8 0.0 0.00011 22.1 0.0 3.6 3 0 0 3 3 3 1 PPR repeat PPR_3 PF13812.6 KOG99640.1 - 9.3e-06 25.6 2.3 0.00013 22.0 0.1 3.7 4 0 0 4 4 4 1 Pentatricopeptide repeat domain PPR_long PF17177.4 KOG99640.1 - 2.6e-05 23.7 0.1 0.00018 21.0 0.0 2.4 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP DUF2258 PF10015.9 KOG99640.1 - 0.04 14.0 1.2 2 8.6 0.6 2.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2258) PPR_1 PF12854.7 KOG99640.1 - 0.07 12.9 0.0 1 9.1 0.0 3.0 2 0 0 2 2 2 0 PPR repeat Ras PF00071.22 KOG99641.1 - 1.1e-50 171.4 0.0 1.7e-50 170.8 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG99641.1 - 1.1e-16 61.1 0.0 2.9e-16 59.8 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG99641.1 - 1.2e-07 31.4 0.1 1.8e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOG99641.1 - 2e-05 24.2 0.2 6.1e-05 22.6 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KOG99641.1 - 0.00089 19.2 0.0 1 9.2 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase PALP PF00291.25 KOG99643.1 - 3e-60 204.2 0.0 3.7e-60 203.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 KOG99643.1 - 1.5e-20 73.4 0.1 2.8e-11 43.7 0.1 2.6 2 0 0 2 2 2 2 CBS domain GHMP_kinases_C PF08544.13 KOG99643.1 - 0.046 14.1 0.0 2 8.9 0.0 2.7 3 0 0 3 3 3 0 GHMP kinases C terminal CSTF2_hinge PF14327.6 KOG99644.1 - 7.5e-25 87.2 2.0 7.5e-25 87.2 2.0 2.6 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.6 KOG99644.1 - 5.8e-05 22.6 5.5 5.8e-05 22.6 5.5 3.4 3 1 1 4 4 4 1 Transcription termination and cleavage factor C-terminal RRM_1 PF00076.22 KOG99644.1 - 0.023 14.5 0.0 0.14 12.0 0.0 2.3 2 1 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MarR PF01047.22 KOG99644.1 - 0.054 13.4 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 MarR family PEMT PF04191.13 KOG99645.1 - 1.8e-55 185.8 8.5 1.3e-33 115.6 1.5 4.1 4 1 1 5 5 5 2 Phospholipid methyltransferase SKICH PF17751.1 KOG99645.1 - 0.012 16.1 0.4 4.7 7.8 0.0 2.8 2 0 0 2 2 2 0 SKICH domain RNase_PH PF01138.21 KOG99646.1 - 1.2e-17 64.6 0.0 1.9e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RRM_1 PF00076.22 KOG99647.1 - 5.1e-43 144.8 0.0 1.5e-20 72.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.15 KOG99647.1 - 0.011 15.7 0.0 2.6 8.1 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain RRM_7 PF16367.5 KOG99647.1 - 0.012 15.7 0.0 6.2 7.0 0.0 2.7 2 1 0 2 2 2 0 RNA recognition motif Nup35_RRM_2 PF14605.6 KOG99647.1 - 0.012 15.6 0.0 0.45 10.6 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif GOLD_2 PF13897.6 KOG99647.1 - 0.53 10.8 0.1 0.53 10.8 0.1 3.8 2 1 1 3 3 3 0 Golgi-dynamics membrane-trafficking SOBP PF15279.6 KOG99647.1 - 0.59 10.7 14.7 0.8 10.3 14.7 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein ORC6 PF05460.13 KOG99647.1 - 2.6 7.2 23.6 3.9 6.7 23.6 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Ndc1_Nup PF09531.10 KOG99647.1 - 6.7 5.3 16.4 7.5 5.1 16.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CDC27 PF09507.10 KOG99647.1 - 7.3 5.9 45.0 9.8 5.4 45.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF2046 PF09755.9 KOG99648.1 - 0.00035 19.9 0.1 0.00045 19.5 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) PRKG1_interact PF15898.5 KOG99648.1 - 0.0064 17.4 3.1 0.013 16.4 3.1 1.6 1 0 0 1 1 1 1 cGMP-dependent protein kinase interacting domain CCDC92 PF14916.6 KOG99648.1 - 0.04 13.7 0.6 0.083 12.7 0.6 1.5 1 0 0 1 1 1 0 Coiled-coil domain of unknown function MerR_2 PF13591.6 KOG99648.1 - 0.048 13.5 0.7 0.099 12.5 0.7 1.6 1 0 0 1 1 1 0 MerR HTH family regulatory protein DHC_N1 PF08385.12 KOG99648.1 - 0.059 12.0 0.1 0.076 11.6 0.1 1.1 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 APC_N_CC PF16689.5 KOG99648.1 - 0.072 13.2 1.1 0.17 12.0 1.1 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain Sas6_CC PF18594.1 KOG99648.1 - 0.12 12.2 0.2 0.22 11.4 0.2 1.4 1 0 0 1 1 1 0 Sas6/XLF/XRCC4 coiled-coil domain NYD-SP28_assoc PF14775.6 KOG99648.1 - 0.17 12.0 0.6 0.4 10.8 0.6 1.6 1 0 0 1 1 1 0 Sperm tail C-terminal domain MCM3AP_GANP PF16769.5 KOG99648.1 - 0.26 9.5 4.4 0.36 9.0 4.4 1.1 1 0 0 1 1 1 0 MCM3AP domain of GANP HALZ PF02183.18 KOG99648.1 - 0.38 11.0 1.5 0.75 10.1 1.5 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper UL41A PF17591.2 KOG99649.1 - 0.0019 18.3 5.4 0.0042 17.2 5.4 1.5 1 0 0 1 1 1 1 Herpesvirus UL41A ABC_export PF16962.5 KOG99649.1 - 0.15 10.4 3.0 0.18 10.2 3.0 1.1 1 0 0 1 1 1 0 Putative ABC exporter MIF4G PF02854.19 KOG99650.1 - 2.2e-51 174.5 0.1 3.7e-51 173.8 0.1 1.4 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 KOG99650.1 - 8.9e-25 86.7 0.1 2.7e-24 85.1 0.1 1.9 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 Fucose_iso_N2 PF07882.12 KOG99650.1 - 0.013 15.1 0.1 0.044 13.4 0.1 1.9 1 0 0 1 1 1 0 L-fucose isomerase, second N-terminal domain Gtr1_RagA PF04670.12 KOG99651.1 - 3.7e-68 229.3 1.4 4.8e-68 229.0 1.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_14 PF13173.6 KOG99651.1 - 0.00034 20.6 0.0 0.0008 19.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 KOG99651.1 - 0.0097 15.1 0.0 0.026 13.7 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) SRPRB PF09439.10 KOG99651.1 - 0.035 13.5 0.1 0.095 12.1 0.0 1.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 KOG99651.1 - 0.064 13.6 0.0 0.11 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain Arf PF00025.21 KOG99651.1 - 0.077 12.4 0.1 0.25 10.8 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family GTP_cyclohydro2 PF00925.20 KOG99651.1 - 0.15 11.6 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 GTP cyclohydrolase II Bot1p PF12298.8 KOG99652.1 - 1.3e-60 204.5 0.0 1.9e-60 203.9 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein Trs65 PF12735.7 KOG99653.1 - 8.6e-46 156.8 1.0 1.5e-45 156.0 1.0 1.4 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 Clathrin_lg_ch PF01086.17 KOG99654.1 - 6.9e-51 173.5 25.5 8.1e-51 173.3 25.5 1.1 1 0 0 1 1 1 1 Clathrin light chain DUF4521 PF15021.6 KOG99654.1 - 0.0032 17.4 7.5 0.004 17.1 7.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF4521) Dna2 PF08696.11 KOG99654.1 - 0.087 12.6 2.3 0.14 12.0 2.3 1.3 1 0 0 1 1 1 0 DNA replication factor Dna2 Bcl-2 PF00452.19 KOG99654.1 - 0.17 12.6 0.1 0.34 11.6 0.1 1.5 1 0 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family O-antigen_lig PF13425.6 KOG99654.1 - 3.6 6.3 4.3 4.8 5.9 4.3 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RsbRD_N PF14361.6 KOG99654.1 - 5.9 7.6 9.1 2.6 8.8 4.7 2.2 2 0 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain SAM_3 PF18016.1 KOG99655.1 - 0.013 15.3 0.2 0.04 13.7 0.2 1.9 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PseudoU_synth_2 PF00849.22 KOG99656.1 - 1.3e-25 90.3 0.0 2.2e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase partial_CstF PF15861.5 KOG99656.1 - 0.1 12.4 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain DUF1764 PF08576.10 KOG99657.1 - 9 7.3 14.7 11 7.0 14.7 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Zip PF02535.22 KOG99657.1 - 9.8 5.3 5.5 10 5.2 5.5 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter PS_Dcarbxylase PF02666.15 KOG99658.1 - 1.4e-54 184.7 0.0 2.3e-54 184.0 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 KOG99658.1 - 2.8e-20 72.5 1.9 3e-12 46.7 0.1 3.5 4 0 0 4 4 4 2 C2 domain tRNA-synt_1g PF09334.11 KOG99659.1 - 2.4e-85 286.6 0.4 2.6e-83 280.0 0.4 2.6 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 KOG99659.1 - 5.1e-19 68.0 2.1 4.3e-10 38.5 0.0 4.1 2 1 1 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 KOG99659.1 - 6.4e-08 32.3 0.0 0.0001 21.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 KOG99659.1 - 0.0076 15.2 0.0 0.012 14.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (K) Fascin PF06268.13 KOG99659.1 - 0.053 13.7 0.0 0.17 12.1 0.0 1.8 2 0 0 2 2 2 0 Fascin domain Yip1 PF04893.17 KOG99660.1 - 1.8e-12 47.3 14.7 2.6e-12 46.8 14.7 1.3 1 0 0 1 1 1 1 Yip1 domain MMR_HSR1_Xtn PF16897.5 KOG99661.1 - 8.2e-37 125.5 1.0 1.8e-36 124.4 1.0 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 KOG99661.1 - 1.4e-21 76.7 0.1 2.9e-21 75.7 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 KOG99661.1 - 4.8e-19 68.2 0.1 1.3e-18 66.7 0.0 1.8 2 0 0 2 2 2 1 TGS domain FeoB_N PF02421.18 KOG99661.1 - 2.5e-13 49.9 0.0 4.1e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOG99661.1 - 0.00025 21.2 0.5 0.084 12.9 0.0 2.5 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 KOG99661.1 - 0.0012 18.3 0.1 0.002 17.5 0.1 1.3 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 KOG99661.1 - 0.0091 15.4 0.7 0.037 13.5 0.1 2.1 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KOG99661.1 - 0.022 15.0 1.2 0.12 12.6 0.1 2.6 1 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 KOG99661.1 - 0.037 13.1 0.1 0.11 11.6 0.0 1.8 2 0 0 2 2 2 0 MCM P-loop domain Ras PF00071.22 KOG99661.1 - 0.041 13.5 0.5 1.1 8.8 0.0 2.3 2 0 0 2 2 2 0 Ras family AAA_16 PF13191.6 KOG99661.1 - 0.066 13.6 0.2 0.11 12.8 0.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain CBP4 PF07960.11 KOG99662.1 - 1.9e-56 189.4 1.4 2.3e-56 189.2 1.4 1.0 1 0 0 1 1 1 1 CBP4 DUF4574 PF15141.6 KOG99662.1 - 0.00097 19.0 0.9 0.0028 17.5 0.0 1.9 2 0 0 2 2 2 1 Ubiquinol-cytochrome-c reductase complex assembly factor 3 LAMTOR PF15454.6 KOG99662.1 - 0.1 13.2 1.0 0.1 13.2 1.0 2.2 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator SE PF08491.10 KOG99663.1 - 6.6e-125 415.7 0.0 8.6e-125 415.3 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 KOG99663.1 - 9.3e-14 51.4 0.0 1.3e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOG99663.1 - 8.6e-07 28.8 0.2 0.00014 21.6 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOG99663.1 - 0.0018 18.8 0.3 0.0059 17.1 0.1 2.0 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOG99663.1 - 0.0068 15.5 0.7 0.015 14.4 0.7 1.5 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 KOG99663.1 - 0.009 16.2 0.1 0.019 15.2 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KOG99663.1 - 0.014 14.6 0.2 0.049 12.9 0.1 1.9 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 KOG99663.1 - 0.022 14.8 0.1 0.039 14.0 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 KOG99663.1 - 0.025 13.8 0.5 0.082 12.1 0.1 1.9 2 0 0 2 2 2 0 Thi4 family 3HCDH_N PF02737.18 KOG99663.1 - 0.025 14.4 0.2 0.041 13.8 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 KOG99663.1 - 0.044 13.1 0.3 0.078 12.3 0.3 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 KOG99663.1 - 0.13 10.9 0.6 0.73 8.5 0.1 1.9 2 0 0 2 2 2 0 HI0933-like protein GDI PF00996.18 KOG99663.1 - 0.14 10.6 0.0 0.24 9.9 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor ApbA PF02558.16 KOG99663.1 - 0.16 11.6 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 KOG99663.1 - 0.18 11.4 0.2 0.46 10.0 0.1 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 KOG99663.1 - 0.25 11.6 1.6 0.42 10.9 0.1 2.1 3 0 0 3 3 2 0 Saccharopine dehydrogenase NADP binding domain AATase PF07247.12 KOG99664.1 - 3e-198 659.4 0.6 3.4e-198 659.2 0.6 1.0 1 0 0 1 1 1 1 Alcohol acetyltransferase Tri3 PF07428.11 KOG99664.1 - 0.031 13.2 0.0 0.065 12.1 0.0 1.4 1 1 0 1 1 1 0 15-O-acetyltransferase Tri3 LsmAD PF06741.13 KOG99665.1 - 4.8e-29 100.7 1.4 1e-28 99.6 0.0 2.4 2 0 0 2 2 2 1 LsmAD domain SM-ATX PF14438.6 KOG99665.1 - 3.5e-14 52.7 0.1 8.2e-14 51.5 0.1 1.7 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 KOG99665.1 - 0.037 14.1 0.0 0.077 13.1 0.0 1.6 1 0 0 1 1 1 0 Scd6-like Sm domain CENP-Q PF13094.6 KOG99666.1 - 1.8e-05 25.0 7.3 1.8e-05 25.0 7.3 2.9 2 2 1 3 3 3 1 CENP-Q, a CENPA-CAD centromere complex subunit Connexin40_C PF16791.5 KOG99666.1 - 1 10.7 6.2 0.22 12.8 1.3 2.5 2 1 0 2 2 2 0 Connexin 40 C-terminal domain Tantalus PF15386.6 KOG99666.1 - 3.3 7.9 8.1 39 4.4 0.1 3.6 2 1 1 3 3 3 0 Drosophila Tantalus-like Ribonuc_red_sm PF00268.21 KOG99667.1 - 1.4e-86 290.5 4.6 1.7e-86 290.2 4.6 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain zf-Tim10_DDP PF02953.15 KOG99669.1 - 6.9e-19 67.3 0.5 9.5e-19 66.8 0.5 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger UCR_UQCRX_QCR9 PF05365.12 KOG99670.1 - 5.3e-27 93.5 4.7 6e-27 93.4 4.7 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like DUF2976 PF11190.8 KOG99670.1 - 0.0072 16.1 0.1 0.0075 16.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2976) DUF5455 PF17537.2 KOG99670.1 - 0.054 13.9 0.2 0.068 13.6 0.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5455) zf-UBR PF02207.20 KOG99671.1 - 9.3e-14 51.4 20.5 9.3e-14 51.4 20.5 2.6 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 KOG99671.1 - 0.00023 20.9 0.0 0.00064 19.5 0.0 1.7 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS zf-RING_2 PF13639.6 KOG99671.1 - 0.0006 20.1 2.7 0.0006 20.1 2.7 3.2 3 0 0 3 3 3 1 Ring finger domain tRNA-synt_1b PF00579.25 KOG99672.1 - 3.6e-78 262.8 0.0 4.6e-78 262.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TFIIF_alpha PF05793.12 KOG99673.1 - 1e-09 37.6 0.5 1e-09 37.6 0.5 3.0 3 1 1 4 4 4 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF383 PF04063.14 KOG99674.1 - 3.2e-63 212.9 3.0 6.7e-63 211.8 0.6 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.13 KOG99674.1 - 3.4e-22 78.1 0.1 9.3e-22 76.6 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF384) NOA36 PF06524.12 KOG99674.1 - 0.35 10.2 7.1 0.5 9.6 7.1 1.2 1 0 0 1 1 1 0 NOA36 protein Mad3_BUB1_I PF08311.12 KOG99675.1 - 4.1e-33 114.0 0.7 8.6e-33 113.0 0.7 1.6 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.11 KOG99675.1 - 3.6e-23 81.5 1.0 1.7e-22 79.4 0.2 2.4 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase PF00069.25 KOG99675.1 - 6.3e-15 55.2 0.0 1.1e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99675.1 - 0.0023 17.3 0.0 0.0043 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Mad3_BUB1_I_2 PF17014.5 KOG99675.1 - 0.0039 17.3 1.0 0.011 15.9 1.0 1.7 1 0 0 1 1 1 1 Putative Mad3/BUB1 like region 1 protein Glyco_hydro_16 PF00722.21 KOG99676.1 - 8.8e-47 158.9 2.7 8.8e-47 158.9 2.7 2.6 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 AA_permease PF00324.21 KOG99677.1 - 1.5e-140 469.0 32.1 1.7e-140 468.8 32.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG99677.1 - 3.6e-37 128.2 35.1 4.3e-37 127.9 35.1 1.0 1 0 0 1 1 1 1 Amino acid permease Pet100 PF09803.9 KOG99677.1 - 0.18 12.3 0.0 0.45 11.1 0.0 1.6 1 0 0 1 1 1 0 Pet100 UPF0139 PF03669.13 KOG99677.1 - 5.6 6.9 5.7 2.6 8.0 0.3 3.0 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0139) Gp_dh_C PF02800.20 KOG99678.1 - 4.8e-72 240.7 0.1 8.4e-72 239.9 0.1 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 KOG99678.1 - 1.1e-38 131.6 0.0 2.7e-38 130.4 0.0 1.7 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 KOG99678.1 - 0.011 15.9 1.7 0.017 15.3 0.4 2.2 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.19 KOG99678.1 - 0.079 12.3 0.1 0.22 10.9 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Biotin_lipoyl PF00364.22 KOG99679.1 - 5.8e-18 64.5 0.1 9.6e-18 63.8 0.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 KOG99679.1 - 4.7e-06 26.8 0.0 1.4e-05 25.4 0.0 1.8 1 0 0 1 1 1 1 e3 binding domain HlyD_3 PF13437.6 KOG99679.1 - 0.0026 18.4 0.4 2.4 8.9 0.0 2.7 1 1 1 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 KOG99679.1 - 0.057 13.3 0.1 0.46 10.4 0.0 2.3 2 0 0 2 2 2 0 Biotin-lipoyl like FGGY_N PF00370.21 KOG99680.1 - 9.4e-26 90.9 0.0 6.2e-16 58.7 0.0 2.4 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 KOG99680.1 - 2.1e-16 60.3 0.0 3.2e-14 53.1 0.0 3.3 3 1 0 3 3 3 1 FGGY family of carbohydrate kinases, C-terminal domain RNase_PH PF01138.21 KOG99681.1 - 4e-25 88.8 0.0 5.6e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KOG99681.1 - 5.5e-06 26.3 0.4 2.2e-05 24.4 0.1 2.1 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 DUF3533 PF12051.8 KOG99683.1 - 1.3e-129 432.5 17.8 1.5e-129 432.2 17.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) PDR_CDR PF06422.12 KOG99683.1 - 0.1 12.5 0.1 0.4 10.6 0.1 2.0 1 0 0 1 1 1 0 CDR ABC transporter DUF1003 PF06210.11 KOG99683.1 - 0.79 9.9 2.9 26 5.0 1.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) TPR_2 PF07719.17 KOG99684.1 - 0.19 11.9 3.6 6.1 7.2 0.0 4.8 6 1 0 6 6 6 0 Tetratricopeptide repeat PMT PF02366.18 KOG99685.1 - 8.2e-93 310.5 21.0 8.2e-93 310.5 21.0 1.8 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 KOG99685.1 - 2.4e-54 184.0 15.8 2.4e-54 184.0 15.8 2.4 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 KOG99685.1 - 1.1e-23 84.1 0.0 2e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 MIR domain HTH_Tnp_1 PF01527.20 KOG99685.1 - 0.23 11.8 0.1 6.5 7.1 0.0 2.4 2 0 0 2 2 2 0 Transposase WD40 PF00400.32 KOG99686.1 - 7.5e-39 131.0 11.1 3e-06 27.8 0.0 10.2 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG99686.1 - 9e-15 54.8 4.3 0.25 11.7 0.0 8.2 5 4 4 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 KOG99686.1 - 0.056 13.4 0.2 23 4.8 0.1 3.4 2 1 0 2 2 2 0 Transcription factor IIIC subunit delta N-term GST_C PF00043.25 KOG99687.1 - 8.9e-08 32.2 0.0 1.5e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KOG99687.1 - 3.1e-05 24.2 0.0 5.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOG99687.1 - 0.036 14.1 0.0 0.063 13.3 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain CTP_transf_like PF01467.26 KOG99688.1 - 3.5e-33 114.8 0.0 7.3e-33 113.8 0.0 1.6 1 0 0 1 1 1 1 Cytidylyltransferase-like C_Hendra PF16821.5 KOG99688.1 - 0.027 14.3 4.5 0.084 12.7 4.5 1.8 1 0 0 1 1 1 0 C protein from hendra and measles viruses Trefoil PF00088.18 KOG99688.1 - 0.13 12.2 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 Trefoil (P-type) domain Rhodanese PF00581.20 KOG99689.1 - 4e-08 33.7 0.0 6.4e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain FTHFS PF01268.19 KOG99690.1 - 2.7e-251 834.6 1.0 3.8e-251 834.1 1.0 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 KOG99690.1 - 9.4e-60 200.5 2.2 1.6e-59 199.8 0.2 2.2 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 KOG99690.1 - 9.7e-38 129.0 0.0 8.4e-37 126.0 0.0 2.4 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Glyco_trans_1_4 PF13692.6 KOG99690.1 - 0.045 14.2 0.0 0.24 11.8 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferases group 1 Shikimate_DH PF01488.20 KOG99690.1 - 0.099 12.7 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase RNA_helicase PF00910.22 KOG99691.1 - 0.021 15.2 0.1 0.054 13.9 0.0 1.8 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.6 KOG99691.1 - 0.039 14.0 0.0 0.088 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOG99691.1 - 0.097 13.2 0.0 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 KOG99691.1 - 0.12 12.4 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NB-ARC PF00931.22 KOG99691.1 - 0.16 11.2 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Mvb12 PF09452.10 KOG99692.1 - 2.1e-38 130.6 0.8 2.4e-38 130.4 0.8 1.0 1 0 0 1 1 1 1 ESCRT-I subunit Mvb12 ETF PF01012.21 KOG99693.1 - 1.1e-40 139.5 0.0 1.4e-40 139.2 0.0 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Hydrolase PF00702.26 KOG99694.1 - 7.9e-16 59.0 0.0 1.3e-15 58.2 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOG99694.1 - 2.8e-12 47.4 0.0 4e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KOG99694.1 - 1.3e-08 34.9 0.6 6e-06 26.2 0.0 2.9 1 1 2 3 3 3 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOG99694.1 - 2.5e-05 24.4 0.3 0.018 15.1 0.4 2.5 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 KOG99694.1 - 6.3e-05 22.5 0.2 0.00014 21.3 0.2 1.6 1 1 0 1 1 1 1 Putative Phosphatase Thioredoxin PF00085.20 KOG99695.1 - 1.5e-31 108.4 0.1 2.1e-31 107.9 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KOG99695.1 - 1.4e-07 31.9 0.3 1.7e-06 28.5 0.3 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 KOG99695.1 - 8e-07 28.9 0.0 1e-06 28.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KOG99695.1 - 7.9e-06 26.1 0.0 0.00027 21.2 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.21 KOG99695.1 - 9.2e-06 25.6 0.0 1.1e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family DIM1 PF02966.16 KOG99695.1 - 4.3e-05 23.3 0.0 6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Mitosis protein DIM1 Redoxin PF08534.10 KOG99695.1 - 0.00032 20.4 0.1 0.00041 20.1 0.1 1.3 1 0 0 1 1 1 1 Redoxin OST3_OST6 PF04756.13 KOG99695.1 - 0.00045 19.7 0.0 0.0005 19.5 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family TraF PF13728.6 KOG99695.1 - 0.042 13.7 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein DUF4290 PF14123.6 KOG99695.1 - 0.054 13.1 0.0 0.082 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4290) Thioredoxin_7 PF13899.6 KOG99695.1 - 0.073 13.3 0.1 0.18 12.0 0.1 1.8 1 1 0 1 1 1 0 Thioredoxin-like MMR_HSR1_C PF08438.10 KOG99696.1 - 2.9e-34 118.0 0.0 4.5e-34 117.4 0.0 1.3 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 KOG99696.1 - 4.4e-20 71.9 0.0 8.3e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOG99696.1 - 2.9e-06 26.9 0.2 1.3e-05 24.8 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOG99696.1 - 0.012 15.7 0.2 0.048 13.7 0.1 2.1 3 0 0 3 3 3 0 Dynamin family GTP_EFTU PF00009.27 KOG99696.1 - 0.018 14.6 0.2 6.9 6.1 0.0 2.5 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.18 KOG99696.1 - 0.026 13.9 0.4 0.54 9.6 0.2 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family KTI12 PF08433.10 KOG99696.1 - 0.12 11.8 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 RsgA_GTPase PF03193.16 KOG99696.1 - 0.13 12.2 0.1 5.5 6.9 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase zf-ZPR1 PF03367.13 KOG99697.1 - 1.4e-115 382.5 7.5 1.5e-57 193.9 2.5 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Terminase_GpA PF05876.12 KOG99697.1 - 0.068 11.7 0.4 0.12 10.9 0.4 1.3 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) DUF2294 PF10057.9 KOG99697.1 - 0.15 12.2 0.8 0.6 10.3 0.2 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2294) Gal4_dimer PF03902.13 KOG99697.1 - 0.28 11.4 1.5 14 6.0 0.1 2.8 3 0 0 3 3 3 0 Gal4-like dimerisation domain zinc-ribbons_6 PF07191.12 KOG99697.1 - 8 6.5 10.4 0.31 11.0 1.9 2.6 2 1 0 2 2 2 0 zinc-ribbons AATase PF07247.12 KOG99698.1 - 6.2e-60 203.2 6.4 5.7e-59 200.0 6.4 1.9 1 1 0 1 1 1 1 Alcohol acetyltransferase Casc1_N PF15927.5 KOG99698.1 - 0.16 11.7 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus RTA1 PF04479.13 KOG99699.1 - 1.3e-60 204.6 16.2 1.3e-60 204.6 16.2 1.4 2 0 0 2 2 2 1 RTA1 like protein Ribosomal_S2 PF00318.20 KOG99700.1 - 8.8e-26 90.5 0.5 5.6e-14 51.9 0.0 2.4 2 1 1 3 3 3 2 Ribosomal protein S2 40S_SA_C PF16122.5 KOG99700.1 - 0.0034 18.7 13.2 0.0071 17.7 13.2 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus DUF4786 PF16027.5 KOG99700.1 - 0.15 12.6 0.0 0.3 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4786) MRP-S33 PF08293.11 KOG99701.1 - 3e-33 113.9 0.1 3e-33 113.9 0.1 1.9 1 1 1 2 2 2 1 Mitochondrial ribosomal subunit S27 Gpi1 PF05024.15 KOG99702.1 - 4.7e-60 202.9 17.0 4.7e-60 202.9 17.0 1.7 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) Ion_trans PF00520.31 KOG99703.1 - 3.7e-109 363.7 101.8 3.4e-37 128.0 13.7 5.0 4 1 0 4 4 4 4 Ion transport protein EF-hand_1 PF00036.32 KOG99703.1 - 0.07 12.7 0.0 0.28 10.8 0.0 2.1 2 0 0 2 2 2 0 EF hand DUF2516 PF10724.9 KOG99703.1 - 1.5 9.2 5.0 0.99 9.7 1.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2516) CRM1_C PF08767.11 KOG99704.1 - 1.2e-130 435.4 7.2 1.2e-130 435.4 7.2 3.2 3 1 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 KOG99704.1 - 1.2e-37 129.3 6.9 1.2e-37 129.3 6.9 3.8 4 1 0 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 KOG99704.1 - 2.5e-31 107.1 3.5 6.6e-31 105.8 3.5 1.8 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 KOG99704.1 - 2.1e-27 95.0 0.5 6.2e-26 90.3 0.3 3.6 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 KOG99704.1 - 1.5e-16 59.6 0.6 1.5e-16 59.6 0.6 2.9 3 0 0 3 3 3 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 KOG99704.1 - 6.9e-16 57.9 2.2 1.8e-15 56.6 0.2 2.9 3 0 0 3 3 3 1 Importin-beta N-terminal domain V-ATPase_H_C PF11698.8 KOG99704.1 - 0.051 13.7 3.1 0.65 10.1 0.1 3.6 3 0 0 3 3 3 0 V-ATPase subunit H DALR_1 PF05746.15 KOG99704.1 - 0.12 12.5 0.6 31 4.8 0.0 3.7 3 0 0 3 3 3 0 DALR anticodon binding domain Ribosomal_L3 PF00297.22 KOG99705.1 - 1.7e-20 73.4 1.5 7.5e-17 61.4 0.7 2.2 1 1 1 2 2 2 2 Ribosomal protein L3 SKG6 PF08693.10 KOG99706.1 - 9.1e-13 47.4 6.9 1.5e-12 46.7 6.9 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 KOG99706.1 - 0.0022 17.9 0.9 0.0091 15.9 0.0 2.5 2 0 0 2 2 2 1 TMEM154 protein family ILEI PF15711.5 KOG99706.1 - 0.096 13.2 0.3 2.2 8.8 0.1 2.5 2 0 0 2 2 2 0 Interleukin-like EMT inducer STE2 PF02116.15 KOG99706.1 - 0.097 12.0 0.1 0.15 11.4 0.1 1.2 1 0 0 1 1 1 0 Fungal pheromone mating factor STE2 GPCR Syndecan PF01034.20 KOG99706.1 - 0.13 12.2 0.1 0.33 10.9 0.1 1.6 1 0 0 1 1 1 0 Syndecan domain RRM_1 PF00076.22 KOG99707.1 - 0.01 15.7 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 KOG99707.1 - 0.019 15.1 0.1 0.05 13.8 0.1 1.6 1 0 0 1 1 1 0 BRCA1-associated protein 2 EthD PF07110.11 KOG99707.1 - 0.13 13.4 0.0 1.8 9.8 0.0 2.6 2 1 0 2 2 2 0 EthD domain ANAPC4_WD40 PF12894.7 KOG99708.1 - 0.021 15.1 0.0 1.2 9.5 0.0 3.4 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOG99708.1 - 0.032 13.2 2.3 0.047 12.7 0.2 2.2 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 KOG99708.1 - 0.094 13.6 0.0 8.3 7.5 0.0 3.3 1 1 1 2 2 2 0 WD domain, G-beta repeat DIE2_ALG10 PF04922.12 KOG99709.1 - 1.3e-111 373.7 32.7 1.8e-111 373.2 32.7 1.2 1 0 0 1 1 1 1 DIE2/ALG10 family SMI1_KNR4 PF09346.10 KOG99710.1 - 1.6e-32 112.7 2.1 1.4e-31 109.7 0.0 3.1 2 1 1 3 3 3 1 SMI1 / KNR4 family (SUKH-1) SLT_L PF14718.6 KOG99710.1 - 0.017 15.2 1.3 0.1 12.7 0.0 2.7 3 0 0 3 3 3 0 Soluble lytic murein transglycosylase L domain DUF5436 PF17504.2 KOG99711.1 - 0.35 11.2 2.2 0.38 11.1 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5436) Spo12 PF05032.12 KOG99712.1 - 6.8e-17 61.1 2.2 6.8e-17 61.1 2.2 1.9 2 0 0 2 2 2 1 Spo12 family Band_7 PF01145.25 KOG99713.1 - 9.7e-22 77.8 1.9 9.7e-22 77.8 1.9 1.8 2 0 0 2 2 2 1 SPFH domain / Band 7 family Ank_2 PF12796.7 KOG99714.1 - 2.6e-35 120.9 0.0 1.1e-12 48.4 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOG99714.1 - 2.1e-22 76.8 0.0 0.00033 20.8 0.0 6.2 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.6 KOG99714.1 - 1.9e-21 76.1 1.3 1.7e-05 25.3 0.0 5.2 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 KOG99714.1 - 8.5e-19 67.1 0.0 0.0027 18.1 0.0 5.8 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 KOG99714.1 - 1.2e-18 66.9 0.2 7.5e-05 22.9 0.0 5.6 1 1 5 6 6 6 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOG99715.1 - 1.2e-26 93.1 0.2 2.2e-12 47.4 0.0 4.1 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 KOG99715.1 - 3.6e-16 58.8 3.6 0.035 14.5 0.0 6.8 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 KOG99715.1 - 4.9e-16 58.9 4.5 3.3e-05 24.3 0.0 5.2 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOG99715.1 - 2.1e-15 56.5 2.2 0.0051 17.1 0.0 5.8 3 2 1 5 5 5 5 Ankyrin repeats (many copies) SPX PF03105.19 KOG99715.1 - 4.9e-15 56.4 23.9 3e-07 30.7 4.8 3.8 2 1 2 4 4 4 3 SPX domain Ank_3 PF13606.6 KOG99715.1 - 7.3e-15 53.6 2.9 0.015 15.8 0.0 7.1 7 0 0 7 7 7 4 Ankyrin repeat Nrap_D4 PF17405.2 KOG99715.1 - 0.015 14.7 2.2 0.38 10.1 0.4 2.5 1 1 1 2 2 2 0 Nrap protein nucleotidyltransferase domain 4 Globin PF00042.22 KOG99716.1 - 2.9e-10 40.7 0.2 5e-09 36.7 0.0 2.3 2 0 0 2 2 2 1 Globin FAD_binding_6 PF00970.24 KOG99716.1 - 1.2e-09 38.4 0.0 2e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KOG99716.1 - 2.8e-05 24.7 0.0 7.9e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Protoglobin PF11563.8 KOG99716.1 - 0.0067 16.3 0.3 0.024 14.6 0.3 1.9 1 1 0 1 1 1 1 Protoglobin DUF3695 PF12494.8 KOG99716.1 - 0.35 10.7 1.4 3.4 7.6 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3695) ApoO PF09769.9 KOG99717.1 - 1.5e-30 105.9 0.0 4.1e-30 104.4 0.0 1.7 2 0 0 2 2 2 1 Apolipoprotein O Kelch_5 PF13854.6 KOG99720.1 - 2.3e-31 107.2 2.2 1.8e-06 27.8 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KOG99720.1 - 4.4e-31 106.5 0.4 4.5e-06 26.8 0.0 5.8 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 KOG99720.1 - 6.5e-30 102.9 8.5 2.2e-09 37.2 0.1 6.5 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 KOG99720.1 - 7e-28 96.0 7.2 3.3e-08 33.5 0.1 6.5 5 1 1 6 6 6 6 Kelch motif Kelch_1 PF01344.25 KOG99720.1 - 6e-19 67.4 0.1 1.2e-07 31.2 0.0 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 KOG99720.1 - 2.5e-17 62.1 4.7 0.047 13.7 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Cytochrom_B562 PF07361.11 KOG99720.1 - 0.012 16.2 13.0 0.29 11.8 0.2 3.5 2 2 1 3 3 3 0 Cytochrome b562 ComK PF06338.11 KOG99720.1 - 0.048 13.3 0.2 0.12 11.9 0.2 1.7 1 0 0 1 1 1 0 ComK protein HALZ PF02183.18 KOG99720.1 - 0.55 10.5 0.1 0.55 10.5 0.1 5.9 7 0 0 7 7 7 0 Homeobox associated leucine zipper DUF4019 PF13211.6 KOG99721.1 - 0.048 14.1 0.8 0.11 12.9 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4019) PFK PF00365.20 KOG99722.1 - 1e-184 612.4 1.5 4.4e-105 351.1 0.3 2.1 2 0 0 2 2 2 2 Phosphofructokinase Pfk_N PF18468.1 KOG99722.1 - 2.4e-27 95.2 0.2 6.4e-27 93.8 0.2 1.8 1 0 0 1 1 1 1 Phosphofructokinase N-terminal domain yeast DAGK_cat PF00781.24 KOG99722.1 - 0.016 14.8 0.1 0.085 12.5 0.1 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain ANTH PF07651.16 KOG99723.1 - 6.8e-70 235.2 3.4 6.8e-70 235.2 3.4 2.6 3 0 0 3 3 3 1 ANTH domain ENTH PF01417.20 KOG99723.1 - 2.7e-09 37.2 0.2 2.7e-09 37.2 0.2 2.5 3 0 0 3 3 3 1 ENTH domain 2-oxoacid_dh PF00198.23 KOG99723.1 - 0.0029 17.1 0.0 0.007 15.8 0.0 1.7 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) eIF3_subunit PF08597.10 KOG99723.1 - 4.7 7.0 15.5 0.7 9.8 6.7 3.3 3 1 0 3 3 3 0 Translation initiation factor eIF3 subunit LMBR1 PF04791.16 KOG99723.1 - 9.1 5.1 12.6 15 4.3 12.6 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein MPC PF03650.13 KOG99724.1 - 2.1e-47 159.8 0.1 2.6e-47 159.5 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers DUF4396 PF14342.6 KOG99724.1 - 0.035 14.4 0.3 0.12 12.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4396) ATP-grasp_2 PF08442.10 KOG99725.1 - 9.1e-80 267.0 0.6 1.5e-79 266.3 0.6 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 KOG99725.1 - 4.5e-27 94.8 0.2 1.6e-26 92.9 0.1 2.0 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.6 KOG99725.1 - 7e-07 28.9 0.3 1.2e-06 28.1 0.3 1.5 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 KOG99725.1 - 0.00083 19.2 0.1 0.0027 17.5 0.1 1.8 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain SDA1 PF05285.12 KOG99726.1 - 2.5e-90 303.4 32.6 2.5e-90 303.4 32.6 2.0 2 0 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 KOG99726.1 - 3.9e-21 75.1 0.7 3.9e-21 75.1 0.7 2.1 2 0 0 2 2 2 1 NUC130/3NT domain TFIIB PF00382.19 KOG99727.1 - 2.9e-56 187.4 1.3 3.9e-28 97.3 0.3 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 KOG99727.1 - 3.6e-29 101.1 4.4 3.6e-29 101.1 4.4 3.5 2 1 1 3 3 3 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 KOG99727.1 - 2.6e-11 42.9 2.6 5.5e-11 41.8 2.6 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 KOG99727.1 - 0.0012 18.6 0.4 0.69 9.7 0.1 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain CPDase PF07823.11 KOG99728.1 - 4.4e-87 290.9 0.2 5.1e-87 290.7 0.2 1.0 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 KOG99728.1 - 0.0011 18.9 0.1 0.0022 17.9 0.1 1.5 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily Glucosamine_iso PF01182.20 KOG99729.1 - 1.2e-58 198.7 0.0 1.3e-58 198.6 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase HSF_DNA-bind PF00447.17 KOG99731.1 - 3.3e-21 75.7 1.7 3.3e-21 75.7 1.7 1.9 2 0 0 2 2 2 1 HSF-type DNA-binding RRM_1 PF00076.22 KOG99732.1 - 2.3e-33 113.8 0.7 1e-11 44.5 0.0 5.7 5 1 1 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOG99732.1 - 0.035 14.2 0.3 57 3.9 0.0 3.7 3 0 0 3 3 3 0 RNA recognition motif gp45-slide_C PF09116.10 KOG99732.1 - 0.11 12.6 0.2 0.24 11.4 0.2 1.5 1 0 0 1 1 1 0 gp45 sliding clamp, C terminal NOP19 PF10863.8 KOG99733.1 - 1.4e-60 203.3 6.7 1.4e-60 203.3 6.7 1.4 2 0 0 2 2 2 1 Nucleolar protein 19 DUF943 PF06092.12 KOG99733.1 - 0.063 13.0 0.3 0.094 12.4 0.3 1.2 1 0 0 1 1 1 0 Enterobacterial putative membrane protein (DUF943) Bromodomain PF00439.25 KOG99734.1 - 1.4e-27 95.6 2.5 2.9e-27 94.5 2.5 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 KOG99734.1 - 2e-09 37.7 0.0 3.8e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOG99734.1 - 4.2e-06 26.7 0.0 7.9e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOG99734.1 - 0.00033 21.0 0.1 0.00069 20.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Proteasome PF00227.26 KOG99735.1 - 7.3e-53 178.9 0.0 9.5e-53 178.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOG99735.1 - 1.9e-12 46.6 0.0 5.3e-12 45.2 0.0 1.8 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Enolase_C PF00113.22 KOG99736.1 - 5.1e-150 498.7 0.0 7.4e-150 498.1 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 KOG99736.1 - 4.7e-55 185.3 0.2 8.6e-55 184.5 0.2 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 KOG99736.1 - 8.1e-07 28.8 0.0 1.5e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 KOG99736.1 - 0.015 14.5 0.2 0.051 12.7 0.0 1.8 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus FAD_binding_3 PF01494.19 KOG99737.1 - 2e-19 70.1 0.2 8e-18 64.8 0.2 2.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 KOG99737.1 - 6.7e-05 22.3 0.0 0.0023 17.2 0.0 2.1 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 KOG99737.1 - 0.00023 20.3 0.0 0.0004 19.5 0.0 1.3 1 0 0 1 1 1 1 Squalene epoxidase Lycopene_cycl PF05834.12 KOG99737.1 - 0.00054 19.1 0.0 0.0067 15.5 0.1 2.4 3 0 0 3 3 3 1 Lycopene cyclase protein Thi4 PF01946.17 KOG99737.1 - 0.0031 16.8 0.0 0.0075 15.5 0.0 1.6 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 KOG99737.1 - 0.025 14.8 0.0 0.062 13.5 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KOG99737.1 - 0.026 13.8 0.0 0.35 10.1 0.0 2.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOG99737.1 - 0.026 13.6 0.0 0.057 12.5 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 KOG99737.1 - 0.029 14.9 0.0 3.9 8.1 0.0 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOG99737.1 - 0.1 11.3 0.0 0.16 10.6 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_9 PF13454.6 KOG99737.1 - 0.11 12.4 0.0 0.38 10.7 0.0 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 KOG99737.1 - 0.12 11.2 0.0 0.63 8.8 0.0 2.1 3 0 0 3 3 3 0 Tryptophan halogenase DAO PF01266.24 KOG99737.1 - 0.14 11.7 0.0 0.64 9.5 0.0 2.1 2 1 1 3 3 3 0 FAD dependent oxidoreductase HU-HIG PF18291.1 KOG99737.1 - 0.14 12.2 0.0 8.8 6.4 0.0 2.3 2 0 0 2 2 2 0 HU domain fused to wHTH, Ig, or Glycine-rich motif 6PGD PF00393.19 KOG99738.1 - 1.3e-124 415.3 0.0 1.6e-124 415.0 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 KOG99738.1 - 9.9e-50 168.8 0.0 1.4e-49 168.3 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 KOG99738.1 - 0.087 12.2 0.1 0.23 10.8 0.1 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_11 PF14833.6 KOG99738.1 - 0.11 12.8 0.0 0.38 11.0 0.0 1.9 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 KOG99738.1 - 0.15 12.7 0.2 0.28 11.8 0.2 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Mito_carr PF00153.27 KOG99739.1 - 7.2e-59 195.7 1.4 3.5e-22 78.1 0.0 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOG99739.1 - 0.068 12.3 0.0 0.18 10.9 0.0 1.7 1 0 0 1 1 1 0 Gammaproteobacterial serine protease XPG_N PF00752.17 KOG99740.1 - 1.7e-37 128.0 0.1 5.5e-37 126.3 0.0 2.0 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 KOG99740.1 - 1.1e-26 93.0 0.0 5.2e-26 90.8 0.0 2.3 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 KOG99740.1 - 0.00066 19.2 0.0 0.0022 17.5 0.0 2.0 1 1 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 KOG99740.1 - 0.0022 18.6 0.0 0.0072 16.9 0.0 1.9 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold MFS_1 PF07690.16 KOG99741.1 - 1.6e-32 112.8 25.2 2.6e-32 112.1 24.7 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Adaptin_N PF01602.20 KOG99742.1 - 1.5e-133 446.1 14.0 1.9e-133 445.8 14.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KOG99742.1 - 1.6e-13 51.0 20.9 1.9e-13 50.7 0.2 5.0 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOG99742.1 - 8.9e-13 48.4 0.2 4.8e-08 33.3 0.0 5.3 5 0 0 5 5 5 1 HEAT repeats HEAT PF02985.22 KOG99742.1 - 2e-09 36.9 6.5 0.048 13.9 0.0 6.6 6 0 0 6 6 6 3 HEAT repeat UNC45-central PF11701.8 KOG99742.1 - 0.00064 19.7 5.7 0.0026 17.7 0.0 3.4 4 1 1 5 5 5 1 Myosin-binding striated muscle assembly central Cohesin_HEAT PF12765.7 KOG99742.1 - 0.0014 18.9 0.6 0.066 13.5 0.1 3.2 1 1 1 2 2 2 1 HEAT repeat associated with sister chromatid cohesion HEAT_EZ PF13513.6 KOG99742.1 - 0.0022 18.5 3.1 4.6 7.8 0.0 5.1 5 0 0 5 5 5 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 KOG99742.1 - 0.043 14.4 0.1 0.99 10.0 0.0 3.2 2 1 0 2 2 2 0 Vacuolar 14 Fab1-binding region FAST_1 PF06743.15 KOG99742.1 - 0.083 12.9 0.2 0.67 9.9 0.1 2.8 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 Kdo PF06293.14 KOG99743.1 - 1.2e-07 31.4 0.0 1.8e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 KOG99743.1 - 0.00056 19.4 0.0 0.00071 19.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 KOG99743.1 - 0.0011 18.9 0.3 0.13 12.2 0.2 2.2 1 1 0 2 2 2 2 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 KOG99743.1 - 0.027 13.8 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase DUF1679 PF07914.11 KOG99743.1 - 0.089 11.6 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Say1_Mug180 PF10340.9 KOG99744.1 - 2.2e-158 527.0 1.9 2.5e-158 526.8 1.9 1.0 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 KOG99744.1 - 1.6e-13 51.0 0.0 2.3e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold tRNA-synt_1g PF09334.11 KOG99745.1 - 7.4e-157 522.1 0.5 1.1e-156 521.5 0.5 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) MetRS-N PF09635.10 KOG99745.1 - 1.2e-52 177.5 6.0 2.4e-52 176.6 6.0 1.5 1 0 0 1 1 1 1 MetRS-N binding domain tRNA-synt_1 PF00133.22 KOG99745.1 - 2e-09 36.3 0.6 0.00065 18.1 0.4 2.4 1 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Sigma54_CBD PF04963.13 KOG99745.1 - 0.025 14.4 0.4 0.36 10.7 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 factor, core binding domain PhoD PF09423.10 KOG99746.1 - 0.00094 18.3 1.9 0.0066 15.5 0.7 2.5 2 1 0 2 2 2 1 PhoD-like phosphatase GTP_cyclohydroI PF01227.22 KOG99747.1 - 4.3e-75 251.1 0.2 5.2e-75 250.8 0.2 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 KOG99747.1 - 1.8e-05 24.8 0.0 5.7e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 QueF-like protein OmpH PF03938.14 KOG99747.1 - 0.008 16.5 0.8 1.1 9.6 0.1 2.1 2 0 0 2 2 2 2 Outer membrane protein (OmpH-like) DnaJ_CXXCXGXG PF00684.19 KOG99748.1 - 1e-05 25.8 7.7 0.004 17.5 0.9 2.4 2 0 0 2 2 2 2 DnaJ central domain HypA PF01155.19 KOG99748.1 - 0.09 12.8 3.0 1.1 9.2 0.5 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 KOG99748.1 - 0.11 12.5 6.6 0.55 10.3 0.9 2.4 2 0 0 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 KOG99748.1 - 0.21 11.6 2.9 3.3 7.7 0.7 2.3 2 0 0 2 2 2 0 zinc-ribbons Pap_E4 PF02711.14 KOG99748.1 - 0.48 11.4 13.0 0.85 10.6 13.0 1.3 1 0 0 1 1 1 0 E4 protein zf-RING_5 PF14634.6 KOG99748.1 - 4.8 7.2 7.6 21 5.1 0.2 3.1 2 1 1 3 3 3 0 zinc-RING finger domain AAA PF00004.29 KOG99749.1 - 4.7e-50 169.4 0.0 1.3e-42 145.4 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG99749.1 - 4e-08 32.9 0.0 1.6e-07 31.0 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 KOG99749.1 - 4.1e-07 30.3 0.0 1.1e-05 25.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KOG99749.1 - 5.2e-06 27.0 0.3 0.0001 22.8 0.1 3.1 3 1 0 3 3 2 1 AAA ATPase domain IstB_IS21 PF01695.17 KOG99749.1 - 2.8e-05 23.9 0.0 8.4e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_5 PF07728.14 KOG99749.1 - 0.00025 21.1 0.0 0.0008 19.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ResIII PF04851.15 KOG99749.1 - 0.00075 19.5 0.0 0.0044 17.0 0.0 2.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Bromodomain PF00439.25 KOG99749.1 - 0.0012 18.8 0.0 0.0043 17.1 0.0 1.9 1 0 0 1 1 1 1 Bromodomain Sigma54_activ_2 PF14532.6 KOG99749.1 - 0.0041 17.2 0.0 1 9.5 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 KOG99749.1 - 0.0048 16.9 0.0 0.037 14.1 0.0 2.6 2 0 0 2 2 1 1 AAA domain TIP49 PF06068.13 KOG99749.1 - 0.0085 15.3 0.0 0.029 13.6 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_33 PF13671.6 KOG99749.1 - 0.0097 16.1 0.0 0.076 13.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOG99749.1 - 0.011 16.1 1.6 0.18 12.1 0.2 3.0 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KOG99749.1 - 0.02 15.3 0.0 0.087 13.2 0.0 2.2 2 0 0 2 2 1 0 RNA helicase AAA_7 PF12775.7 KOG99749.1 - 0.027 14.0 0.0 0.23 11.0 0.0 2.4 3 0 0 3 3 2 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 KOG99749.1 - 0.03 14.0 0.0 0.71 9.6 0.0 2.9 2 1 0 2 2 2 0 Sigma-54 interaction domain Shugoshin_C PF07557.11 KOG99749.1 - 0.041 13.7 0.7 0.5 10.2 0.1 2.7 2 0 0 2 2 2 0 Shugoshin C terminus Mg_chelatase PF01078.21 KOG99749.1 - 0.043 13.2 0.0 0.15 11.4 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 KOG99749.1 - 0.051 14.1 0.0 0.051 14.1 0.0 3.8 4 1 0 4 4 2 0 ABC transporter AAA_18 PF13238.6 KOG99749.1 - 0.053 14.1 0.6 0.28 11.7 0.0 2.7 2 0 0 2 2 1 0 AAA domain RuvB_N PF05496.12 KOG99749.1 - 0.073 12.8 0.0 0.24 11.1 0.0 1.7 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 KOG99749.1 - 0.092 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 KOG99749.1 - 0.11 12.7 0.6 0.38 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KOG99749.1 - 0.13 11.8 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KOG99749.1 - 0.14 11.9 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KOG99749.1 - 0.15 11.5 0.0 0.33 10.4 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.6 KOG99749.1 - 0.57 9.9 0.0 0.57 9.9 0.0 4.0 4 1 0 4 4 2 0 AAA domain Sec63 PF02889.16 KOG99750.1 - 4.9e-121 402.7 2.7 2.9e-82 275.7 0.1 2.4 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 KOG99750.1 - 2.2e-48 164.4 7.2 1.2e-25 90.3 1.0 4.2 5 0 0 5 5 5 2 DEAD/DEAH box helicase ResIII PF04851.15 KOG99750.1 - 2e-30 106.0 0.0 6.5e-15 55.5 0.0 2.9 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOG99750.1 - 1.3e-18 67.3 0.2 7.5e-08 32.7 0.0 4.1 3 2 0 3 3 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOG99750.1 - 9.2e-05 22.7 10.8 0.07 13.4 0.3 5.1 3 2 1 4 4 3 2 AAA domain Helicase_PWI PF18149.1 KOG99750.1 - 0.00032 20.8 1.3 0.0015 18.7 1.3 2.2 1 0 0 1 1 1 1 N-terminal helicase PWI domain AAA PF00004.29 KOG99750.1 - 0.00056 20.4 8.4 0.091 13.2 0.0 4.7 5 2 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 KOG99750.1 - 0.00056 20.3 2.2 0.074 13.4 0.2 3.3 3 0 0 3 3 3 1 AAA domain PhoH PF02562.16 KOG99750.1 - 0.0026 17.2 0.1 0.49 9.8 0.0 2.8 3 0 0 3 3 3 1 PhoH-like protein IstB_IS21 PF01695.17 KOG99750.1 - 0.0095 15.7 1.3 2.7 7.7 0.0 4.3 5 0 0 5 5 5 1 IstB-like ATP binding protein TniB PF05621.11 KOG99750.1 - 0.022 14.2 0.4 22 4.4 0.1 3.7 3 0 0 3 3 3 0 Bacterial TniB protein MotA_ExbB PF01618.16 KOG99750.1 - 0.16 11.8 0.0 0.45 10.3 0.0 1.7 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family Efg1 PF10153.9 KOG99751.1 - 2.9e-33 114.6 13.4 5.2e-33 113.8 13.4 1.4 1 0 0 1 1 1 1 rRNA-processing protein Efg1 tRNA-synt_2 PF00152.20 KOG99751.1 - 0.027 13.5 0.2 0.033 13.3 0.2 1.2 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) LUD_dom PF02589.15 KOG99751.1 - 0.1 12.3 0.1 0.81 9.4 0.0 2.0 1 1 1 2 2 2 0 LUD domain Pox_A_type_inc PF04508.12 KOG99751.1 - 1.8 8.6 5.8 1.4 8.9 3.0 2.3 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DUF2406 PF10295.9 KOG99752.1 - 1.4e-24 86.6 0.2 2.7e-24 85.6 0.2 1.5 1 0 0 1 1 1 1 Uncharacterised protein (DUF2406) DUF3591 PF12157.8 KOG99753.1 - 2.8e-169 563.5 3.3 4.8e-169 562.7 3.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 KOG99753.1 - 3.7e-06 26.7 0.4 7.4e-06 25.7 0.4 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 KOG99753.1 - 0.16 12.1 1.8 0.16 12.1 0.4 1.7 2 0 0 2 2 2 0 Zinc knuckle Rtt102p PF09510.10 KOG99754.1 - 2e-44 151.0 0.1 2.4e-44 150.7 0.1 1.1 1 0 0 1 1 1 1 Rtt102p-like transcription regulator protein RNase_T PF00929.24 KOG99755.1 - 8.7e-13 49.1 0.0 1.9e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 KOG99755.1 - 0.021 14.5 0.2 0.37 10.5 0.2 2.9 2 1 0 2 2 2 0 3'-5' exonuclease EloA-BP1 PF15870.5 KOG99755.1 - 0.062 13.5 1.5 4.7 7.4 0.0 2.6 2 0 0 2 2 2 0 ElonginA binding-protein 1 DUF5051 PF16473.5 KOG99755.1 - 0.095 12.7 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like CTP_transf_like PF01467.26 KOG99756.1 - 5.2e-14 52.6 0.0 7.3e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like Glyco_hydro_17 PF00332.18 KOG99757.1 - 1e-11 45.0 3.5 2.2e-11 43.9 2.6 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 Herpes_UL4 PF03277.13 KOG99757.1 - 0.087 12.4 2.6 0.2 11.2 2.6 1.6 1 0 0 1 1 1 0 Herpesvirus UL4 family DUF5593 PF18007.1 KOG99757.1 - 0.62 10.8 4.9 1.7 9.4 4.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5593) NUDE_C PF04880.13 KOG99757.1 - 1.8 9.0 5.6 3 8.3 5.6 1.5 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region RAP1 PF07218.11 KOG99757.1 - 7 4.8 7.4 9.8 4.3 7.4 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) G-patch PF01585.23 KOG99758.1 - 9.3e-12 44.6 0.0 1.8e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KOG99758.1 - 0.0016 18.5 0.0 0.0016 18.5 0.0 3.3 2 1 0 2 2 1 1 G-patch domain DUF2052 PF09747.9 KOG99758.1 - 0.0039 17.3 13.9 0.0054 16.9 13.9 1.2 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 KOG99758.1 - 0.01 14.2 23.9 0.013 13.8 23.9 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 KOG99758.1 - 0.017 15.0 16.6 0.021 14.7 16.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF3_subunit PF08597.10 KOG99758.1 - 0.036 14.0 33.8 0.057 13.3 33.8 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Spt5_N PF11942.8 KOG99758.1 - 0.051 14.5 17.2 0.13 13.3 17.2 1.7 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal RRN3 PF05327.11 KOG99758.1 - 0.16 10.5 10.3 0.18 10.3 10.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Tim54 PF11711.8 KOG99758.1 - 0.18 10.6 16.1 0.27 10.0 16.1 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SAPS PF04499.15 KOG99758.1 - 0.41 9.4 13.0 0.48 9.2 13.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein VIR_N PF15912.5 KOG99758.1 - 0.44 10.1 14.0 0.63 9.6 14.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal PTPRCAP PF15713.5 KOG99758.1 - 0.5 10.7 19.0 0.98 9.7 19.0 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated MCM_bind PF09739.9 KOG99758.1 - 0.52 8.7 17.8 0.74 8.2 17.8 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor YL1 PF05764.13 KOG99758.1 - 0.61 10.2 42.5 1 9.5 42.6 1.4 1 1 0 1 1 1 0 YL1 nuclear protein GREB1 PF15782.5 KOG99758.1 - 0.61 7.1 8.6 0.63 7.1 8.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4775 PF16001.5 KOG99758.1 - 0.73 9.2 32.8 1 8.7 32.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Neur_chan_memb PF02932.16 KOG99758.1 - 0.94 9.5 8.3 1.1 9.2 8.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 KOG99758.1 - 1.6 7.5 11.1 1.9 7.2 11.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Hid1 PF12722.7 KOG99758.1 - 2.6 6.1 16.0 3 5.9 16.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SLC12 PF03522.15 KOG99758.1 - 3.4 6.6 18.1 4.3 6.3 18.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 NPR3 PF03666.13 KOG99758.1 - 4.5 5.9 20.4 6.3 5.5 20.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3987 PF13148.6 KOG99758.1 - 7.1 5.5 14.0 10 5.0 14.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) TRAP_alpha PF03896.16 KOG99758.1 - 8.9 5.4 10.8 15 4.7 10.8 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit ABC_membrane PF00664.23 KOG99759.1 - 4e-84 282.5 39.8 2e-48 165.4 14.9 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOG99759.1 - 1.1e-45 155.5 4.7 2.6e-28 99.2 0.0 3.6 3 1 0 3 3 2 2 ABC transporter SMC_N PF02463.19 KOG99759.1 - 2.4e-09 36.9 6.8 0.058 12.8 0.5 4.4 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOG99759.1 - 1.5e-08 34.2 1.6 0.00042 20.0 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 KOG99759.1 - 4.9e-07 30.5 16.9 0.0037 17.8 7.2 4.0 3 1 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 KOG99759.1 - 5e-07 29.8 0.4 0.0023 17.9 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 KOG99759.1 - 1.3e-06 28.5 6.7 0.037 13.8 0.0 4.7 5 1 1 6 6 5 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 KOG99759.1 - 4.4e-06 26.8 0.4 0.12 12.5 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 KOG99759.1 - 1.2e-05 25.9 0.7 0.24 11.9 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_15 PF13175.6 KOG99759.1 - 1.7e-05 24.7 0.0 0.81 9.3 0.0 3.8 3 1 1 4 4 3 2 AAA ATPase domain T2SSE PF00437.20 KOG99759.1 - 0.00017 20.8 0.0 0.02 14.0 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_7 PF12775.7 KOG99759.1 - 0.00058 19.4 0.1 1.1 8.7 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region Zeta_toxin PF06414.12 KOG99759.1 - 0.00064 19.0 0.0 0.048 12.9 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.6 KOG99759.1 - 0.00073 20.0 0.0 0.038 14.4 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 KOG99759.1 - 0.00089 19.0 0.2 0.29 10.8 0.0 3.3 4 0 0 4 4 3 1 IstB-like ATP binding protein AAA_22 PF13401.6 KOG99759.1 - 0.0014 19.0 6.9 0.73 10.1 0.1 3.9 3 1 0 3 3 3 2 AAA domain AAA_30 PF13604.6 KOG99759.1 - 0.0015 18.3 0.6 0.99 9.1 0.0 2.8 3 0 0 3 3 2 1 AAA domain MeaB PF03308.16 KOG99759.1 - 0.0019 17.2 1.8 2 7.3 0.1 3.2 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 KOG99759.1 - 0.0076 16.6 0.1 12 6.3 0.0 3.7 3 0 0 3 3 3 0 RNA helicase cobW PF02492.19 KOG99759.1 - 0.011 15.3 2.0 1.1 8.9 0.0 3.1 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 KOG99759.1 - 0.02 15.1 0.7 0.79 9.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_27 PF13514.6 KOG99759.1 - 0.022 14.4 0.4 1.3 8.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 KOG99759.1 - 0.027 13.8 0.6 4.6 6.5 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family NTPase_1 PF03266.15 KOG99759.1 - 0.04 13.8 0.3 3.7 7.4 0.1 2.6 2 0 0 2 2 2 0 NTPase ATP-synt_ab PF00006.25 KOG99759.1 - 0.04 13.6 0.1 7.7 6.1 0.0 2.7 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.29 KOG99759.1 - 0.042 14.3 0.9 0.72 10.3 0.1 3.2 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 KOG99759.1 - 0.055 13.1 0.1 1.7 8.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 KOG99759.1 - 0.077 13.1 0.1 0.077 13.1 0.1 2.5 4 0 0 4 4 1 0 Helicase HerA, central domain DUF815 PF05673.13 KOG99759.1 - 0.084 12.0 0.1 1.6 7.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TrwB_AAD_bind PF10412.9 KOG99759.1 - 0.084 11.8 0.3 5.3 5.8 0.2 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain PRK PF00485.18 KOG99759.1 - 0.42 10.3 1.7 3.9 7.2 0.0 2.8 3 0 0 3 3 2 0 Phosphoribulokinase / Uridine kinase family ATPase_2 PF01637.18 KOG99759.1 - 0.43 10.4 4.4 1.2 9.0 0.0 3.5 3 1 0 3 3 2 0 ATPase domain predominantly from Archaea Dynamin_N PF00350.23 KOG99759.1 - 2 8.5 12.2 0.81 9.7 0.0 3.5 4 0 0 4 4 3 0 Dynamin family Glyco_hydro_17 PF00332.18 KOG99760.1 - 5.4e-98 328.5 4.3 6.1e-98 328.3 4.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 Methyltrn_RNA_3 PF02598.17 KOG99761.1 - 8.4e-62 209.3 0.0 9.9e-62 209.0 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase SURF4 PF02077.15 KOG99762.1 - 2.8e-110 368.1 11.3 3.3e-110 367.9 11.3 1.0 1 0 0 1 1 1 1 SURF4 family TMEM43 PF07787.12 KOG99762.1 - 0.36 10.2 3.7 0.8 9.0 3.7 1.5 1 0 0 1 1 1 0 Transmembrane protein 43 RAC_head PF16717.5 KOG99763.1 - 1.6e-21 77.1 6.5 1.6e-21 77.1 6.5 3.7 4 1 0 4 4 4 1 Ribosome-associated complex head domain DnaJ PF00226.31 KOG99763.1 - 2.4e-15 56.4 0.2 7.7e-15 54.8 0.2 2.0 1 0 0 1 1 1 1 DnaJ domain DEPP PF15343.6 KOG99763.1 - 1.3 9.0 7.8 3.1 7.8 7.8 1.6 1 0 0 1 1 1 0 Decidual protein induced by progesterone family Neur_chan_memb PF02932.16 KOG99763.1 - 2.3 8.2 10.7 13 5.7 0.0 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CemA PF03040.14 KOG99763.1 - 5.7 6.8 5.2 11 5.9 5.2 1.4 1 0 0 1 1 1 0 CemA family BATS PF06968.13 KOG99764.1 - 1.3e-23 82.9 0.2 3.9e-23 81.4 0.1 1.9 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 KOG99764.1 - 5.3e-17 62.7 0.3 3e-16 60.3 0.2 1.9 2 0 0 2 2 2 1 Radical SAM superfamily INPP5B_PH PF16776.5 KOG99764.1 - 0.036 13.8 0.0 0.068 12.9 0.0 1.4 1 0 0 1 1 1 0 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain DegV PF02645.16 KOG99764.1 - 0.092 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein, DegV family COG1307 SRP1_TIP1 PF00660.17 KOG99765.1 - 4.7e-26 90.7 0.0 6.4e-26 90.3 0.0 1.2 1 0 0 1 1 1 1 Seripauperin and TIP1 family CorA PF01544.18 KOG99766.1 - 1.2e-35 123.3 1.9 4e-20 72.3 0.0 2.3 1 1 1 2 2 2 2 CorA-like Mg2+ transporter protein S-methyl_trans PF02574.16 KOG99767.1 - 4.3e-58 197.2 0.0 5e-58 197.0 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase DUF2675 PF11247.8 KOG99767.1 - 0.078 13.1 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2675) AA_permease PF00324.21 KOG99768.1 - 9.2e-36 123.4 7.7 1.1e-35 123.2 7.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG99768.1 - 1e-11 44.3 7.9 1.2e-11 44.1 7.9 1.1 1 0 0 1 1 1 1 Amino acid permease YwiC PF14256.6 KOG99768.1 - 0.031 14.6 0.7 0.031 14.6 0.7 1.8 1 1 0 2 2 2 0 YwiC-like protein ATP_synt_H PF05493.13 KOG99768.1 - 0.063 13.8 1.5 0.063 13.8 1.5 2.2 2 0 0 2 2 2 0 ATP synthase subunit H Asp PF00026.23 KOG99769.1 - 5.8e-58 196.8 9.3 8.4e-58 196.3 9.3 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOG99769.1 - 2.9e-11 43.9 0.3 2.9e-11 43.9 0.3 2.0 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 KOG99769.1 - 9.1e-07 29.4 0.2 0.27 11.9 0.0 3.5 3 0 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 KOG99769.1 - 0.00023 21.7 0.0 4.4 7.9 0.0 3.4 3 0 0 3 3 3 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 KOG99769.1 - 0.01 15.6 0.1 0.55 10.0 0.1 2.4 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal ADH_zinc_N PF00107.26 KOG99770.1 - 1.4e-13 50.9 0.1 2.1e-13 50.4 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOG99770.1 - 0.0034 17.2 0.1 0.042 13.7 0.1 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 KOG99770.1 - 0.0078 17.3 0.0 0.013 16.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Semialdhyde_dh PF01118.24 KOG99770.1 - 0.011 16.1 0.0 0.017 15.5 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Flocculin_t3 PF13928.6 KOG99771.1 - 3.1e-52 174.8 112.5 3e-15 56.4 19.5 6.8 7 0 0 7 7 7 4 Flocculin type 3 repeat PRR20 PF15708.5 KOG99771.1 - 0.0038 17.2 0.1 6.9 6.5 0.0 3.6 1 1 2 3 3 3 1 Proline-rich protein family 20 IBR PF01485.21 KOG99771.1 - 0.28 11.5 12.7 14 6.0 0.2 4.5 5 0 0 5 5 5 0 IBR domain, a half RING-finger domain ArsD PF06953.11 KOG99771.1 - 2.6 8.4 13.6 35 4.8 0.5 4.3 4 0 0 4 4 4 0 Arsenical resistance operon trans-acting repressor ArsD EMI PF07546.13 KOG99771.1 - 6.4 7.6 36.2 0.71 10.7 1.1 5.1 5 0 0 5 5 5 0 EMI domain Ivy PF08816.11 KOG99771.1 - 8.2 6.7 7.3 5 7.3 0.4 2.8 1 1 3 4 4 4 0 Inhibitor of vertebrate lysozyme (Ivy) PA14 PF07691.12 KOG99772.1 - 1.3e-23 83.4 0.0 3.2e-23 82.2 0.0 1.7 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 KOG99772.1 - 5.7e-22 77.9 0.2 5.7e-22 77.9 0.2 2.5 2 1 1 3 3 3 1 GLEYA domain Flocculin PF00624.18 KOG99772.1 - 1e-07 32.0 13.5 1e-07 32.0 13.5 4.8 4 1 1 5 5 5 1 Flocculin repeat CorA PF01544.18 KOG99773.1 - 1.1e-37 130.0 1.0 7.1e-23 81.3 0.0 2.2 1 1 1 2 2 2 2 CorA-like Mg2+ transporter protein CRC_subunit PF08624.10 KOG99774.1 - 1.9e-36 125.5 0.2 4.2e-36 124.4 0.2 1.6 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Lectin_leg-like PF03388.13 KOG99775.1 - 2.2e-60 203.9 0.1 3.4e-60 203.2 0.1 1.3 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 KOG99775.1 - 1.7e-07 31.4 0.4 1.6e-06 28.3 0.4 2.2 1 1 0 1 1 1 1 Bacterial lectin DEP PF00610.21 KOG99776.1 - 6.6e-10 38.9 0.0 2.4e-09 37.1 0.0 2.0 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 KOG99776.1 - 1.3e-08 35.0 0.8 3.9e-07 30.3 0.0 2.7 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain RhoGAP PF00620.27 KOG99776.1 - 1.1e-07 31.8 5.5 2.6e-07 30.6 0.1 3.1 3 1 0 3 3 3 1 RhoGAP domain DUF1640 PF07798.11 KOG99777.1 - 3.3e-53 180.3 8.8 4.1e-53 180.0 8.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) FTA4 PF13093.6 KOG99777.1 - 0.0067 16.3 4.2 0.0077 16.1 4.2 1.1 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 FlaC_arch PF05377.11 KOG99777.1 - 0.039 14.4 4.0 2 8.9 0.3 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Sulfatase_C PF14707.6 KOG99777.1 - 0.071 13.8 1.5 13 6.5 0.1 2.7 1 1 1 2 2 2 0 C-terminal region of aryl-sulfatase OspE PF02471.17 KOG99777.1 - 0.083 13.1 0.5 0.21 11.8 0.3 1.9 2 0 0 2 2 2 0 Borrelia outer surface protein E XhlA PF10779.9 KOG99777.1 - 0.12 12.6 0.2 0.12 12.6 0.2 2.2 2 0 0 2 2 2 0 Haemolysin XhlA DUF5082 PF16888.5 KOG99777.1 - 0.14 12.5 8.2 3.3 8.0 0.5 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF5082) DUF4407 PF14362.6 KOG99777.1 - 0.2 11.0 3.2 0.27 10.6 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ZnuA PF01297.17 KOG99777.1 - 0.21 11.0 1.6 0.43 9.9 1.6 1.6 1 1 0 1 1 1 0 Zinc-uptake complex component A periplasmic Uso1_p115_C PF04871.13 KOG99777.1 - 0.32 11.4 7.8 0.22 11.9 3.2 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Fib_alpha PF08702.10 KOG99777.1 - 0.41 10.8 8.8 0.24 11.6 6.4 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 KOG99777.1 - 0.48 10.5 4.3 5 7.2 4.3 2.2 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4200 PF13863.6 KOG99777.1 - 0.59 10.5 11.8 1.5 9.2 11.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Phage_lysis PF03245.13 KOG99777.1 - 0.74 9.9 7.8 0.51 10.5 0.8 2.2 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein HU-CCDC81_bac_2 PF18175.1 KOG99777.1 - 1.6 8.6 4.3 3 7.8 0.4 2.9 2 1 2 4 4 4 0 CCDC81-like prokaryotic HU domain 2 DUF1664 PF07889.12 KOG99777.1 - 2.5 8.2 8.6 6.2 6.9 0.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PMM PF03332.13 KOG99778.1 - 1.5e-114 381.3 0.3 1.8e-114 381.1 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 KOG99778.1 - 3.5e-05 23.7 0.0 0.0018 18.1 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase OTU PF02338.19 KOG99779.1 - 5e-08 33.5 0.0 8.8e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Nab2 PF11517.8 KOG99779.1 - 0.057 13.7 0.3 0.13 12.5 0.3 1.6 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) FeoA PF04023.14 KOG99779.1 - 0.078 13.2 0.0 0.23 11.7 0.0 1.9 1 1 0 1 1 1 0 FeoA domain VASt PF16016.5 KOG99780.1 - 1.1e-32 113.5 0.0 2.2e-32 112.6 0.0 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 KOG99780.1 - 2.6e-26 91.7 0.0 5.2e-26 90.8 0.0 1.5 1 0 0 1 1 1 1 GRAM domain C_Hendra PF16821.5 KOG99780.1 - 0.33 10.8 1.6 0.66 9.8 1.6 1.5 1 0 0 1 1 1 0 C protein from hendra and measles viruses Cu-oxidase_2 PF07731.14 KOG99781.1 - 5.1e-43 146.1 7.8 3.2e-39 133.8 0.6 2.9 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 KOG99781.1 - 9.8e-39 132.1 4.3 2.1e-36 124.5 0.4 2.9 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 KOG99781.1 - 1.2e-36 126.2 5.1 1.6e-33 116.1 0.6 3.5 3 1 0 3 3 3 2 Multicopper oxidase ADH_zinc_N PF00107.26 KOG99781.1 - 0.018 15.0 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase HeH PF12949.7 KOG99781.1 - 0.19 11.5 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 HeH/LEM domain Sugar_tr PF00083.24 KOG99782.1 - 6.1e-63 213.2 25.5 7.6e-63 212.9 25.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG99782.1 - 6.2e-16 58.3 33.8 3e-14 52.7 15.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Actin PF00022.19 KOG99783.1 - 2.3e-145 484.3 0.0 6.7e-145 482.8 0.0 1.6 1 1 0 1 1 1 1 Actin GerD PF17898.1 KOG99783.1 - 0.14 12.2 0.1 0.38 10.7 0.1 1.7 1 0 0 1 1 1 0 Spore germination GerD central core domain Ras PF00071.22 KOG99784.1 - 4.8e-64 214.8 0.5 6e-64 214.5 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG99784.1 - 7.5e-36 123.0 0.2 1.4e-35 122.1 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG99784.1 - 9.5e-17 61.0 0.4 1.3e-16 60.6 0.4 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOG99784.1 - 1.4e-05 24.5 0.2 2.1e-05 24.0 0.2 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOG99784.1 - 3.5e-05 23.4 0.2 0.00011 21.8 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOG99784.1 - 0.00026 21.1 0.1 0.00051 20.1 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG99784.1 - 0.0023 17.8 0.4 0.056 13.3 0.0 2.3 1 1 1 2 2 2 1 RsgA GTPase SRPRB PF09439.10 KOG99784.1 - 0.0037 16.7 0.7 0.0045 16.4 0.1 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 KOG99784.1 - 0.012 15.1 0.8 0.12 11.9 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 KOG99784.1 - 0.089 12.8 0.1 0.18 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 KOG99784.1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 KOG99784.1 - 0.13 12.6 0.0 0.2 12.0 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 KOG99784.1 - 0.14 12.7 1.5 0.69 10.4 1.5 2.1 1 1 0 1 1 1 0 ABC transporter PcfK PF14058.6 KOG99784.1 - 2.1 8.6 5.8 0.19 12.0 0.2 1.9 2 0 0 2 2 2 0 PcfK-like protein Tubulin PF00091.25 KOG99785.1 - 3.7e-69 232.9 0.0 6.7e-69 232.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOG99785.1 - 2.9e-42 143.8 0.1 5.3e-42 142.9 0.1 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KOG99785.1 - 0.0024 17.6 0.0 0.0043 16.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 KOG99785.1 - 0.0043 16.3 0.0 0.011 15.0 0.0 1.6 2 0 0 2 2 2 1 Tubulin like Misat_Tub_SegII PF10644.9 KOG99785.1 - 0.021 15.2 0.0 0.055 13.8 0.0 1.8 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain RNA_pol PF00940.19 KOG99786.1 - 9.4e-180 597.9 0.0 1.3e-179 597.4 0.0 1.2 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 KOG99786.1 - 1.2e-106 357.0 0.1 2.1e-106 356.1 0.1 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal ACDC PF14733.6 KOG99786.1 - 0.089 13.1 1.0 1.4 9.3 0.1 2.7 2 0 0 2 2 2 0 AP2-coincident C-terminal Mob1_phocein PF03637.17 KOG99787.1 - 7.3e-67 224.6 1.4 1.1e-66 224.0 1.4 1.3 1 0 0 1 1 1 1 Mob1/phocein family DUF726 PF05277.12 KOG99788.1 - 9.6e-143 475.2 2.9 9.6e-143 475.2 2.9 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF726) UPF0565 PF10561.9 KOG99788.1 - 0.029 13.6 0.1 0.21 10.8 0.0 2.4 2 1 0 2 2 2 0 Uncharacterised protein family UPF0565 Kinocilin PF15033.6 KOG99788.1 - 7.9 6.1 7.7 1.8 8.2 3.3 2.2 2 0 0 2 2 2 0 Kinocilin protein Pkinase PF00069.25 KOG99789.1 - 8.1e-61 205.7 0.0 3.4e-37 128.3 0.1 3.1 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99789.1 - 2.1e-23 83.0 0.0 6.3e-19 68.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 KOG99789.1 - 1.1e-06 28.8 0.0 2.1e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 KOG99789.1 - 8e-05 22.1 0.0 0.0056 16.0 0.0 2.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KOG99789.1 - 0.00024 20.5 0.0 0.00047 19.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOG99789.1 - 0.0015 18.5 0.1 0.17 11.8 0.3 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family CopG_antitoxin PF12441.8 KOG99789.1 - 8.8 7.0 8.7 32 5.1 0.5 4.1 4 0 0 4 4 4 0 CopG antitoxin of type II toxin-antitoxin system bZIP_2 PF07716.15 KOG99790.1 - 1.6e-05 24.9 7.6 1.6e-05 24.9 7.6 1.7 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 KOG99790.1 - 3.8e-05 23.7 7.6 6.5e-05 22.9 7.6 1.4 1 0 0 1 1 1 1 bZIP transcription factor Aminotran_5 PF00266.19 KOG99791.1 - 5.2e-22 78.3 0.0 6.8e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Pkinase PF00069.25 KOG99792.1 - 1.6e-24 86.7 0.0 1.1e-23 84.0 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99792.1 - 7.3e-14 51.7 0.0 1e-13 51.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOG99792.1 - 7.1e-06 25.1 0.0 9.6e-06 24.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOG99792.1 - 0.003 17.5 0.0 0.0044 17.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 KOG99792.1 - 0.0074 15.8 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.14 KOG99792.1 - 0.017 14.5 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family THEG4 PF15834.5 KOG99792.1 - 0.14 12.1 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Testis highly expressed protein 4 Lambda_Bor PF06291.11 KOG99792.1 - 0.2 11.7 0.0 0.82 9.7 0.0 1.9 2 0 0 2 2 2 0 Bor protein ABC_tran PF00005.27 KOG99793.1 - 4.4e-17 62.9 0.0 1e-16 61.7 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOG99793.1 - 4.9e-10 39.7 0.2 0.0012 18.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOG99793.1 - 5.2e-05 22.8 0.0 0.13 11.7 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOG99793.1 - 0.0044 16.7 0.0 0.0086 15.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOG99793.1 - 0.022 14.7 0.1 0.059 13.3 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase AAA_15 PF13175.6 KOG99793.1 - 0.024 14.4 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 KOG99793.1 - 0.031 14.0 0.1 0.33 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KOG99793.1 - 0.033 14.7 0.0 0.044 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 KOG99793.1 - 0.035 14.2 0.0 0.058 13.5 0.0 1.3 1 0 0 1 1 1 0 Dynamin family AAA_18 PF13238.6 KOG99793.1 - 0.059 13.9 0.0 0.13 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 KOG99793.1 - 0.09 11.7 0.0 0.16 10.9 0.0 1.4 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 KOG99793.1 - 0.12 12.4 0.1 0.22 11.6 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF3584 PF12128.8 KOG99793.1 - 0.14 9.7 0.1 0.18 9.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_27 PF13514.6 KOG99793.1 - 0.21 11.1 0.0 0.33 10.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain RabGAP-TBC PF00566.18 KOG99794.1 - 1.6e-11 44.3 4.6 3.9e-11 43.0 4.4 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PGAP1 PF07819.13 KOG99795.1 - 2.2e-96 322.1 0.0 3.7e-96 321.3 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 KOG99795.1 - 0.00086 19.2 0.0 0.0019 18.1 0.0 1.6 1 1 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 KOG99795.1 - 0.0011 19.6 0.0 0.0018 18.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOG99795.1 - 0.0011 18.6 0.0 0.0032 17.1 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOG99795.1 - 0.0072 15.6 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 KOG99795.1 - 0.029 14.2 0.0 0.058 13.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF676 PF05057.14 KOG99795.1 - 0.062 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) LCAT PF02450.15 KOG99795.1 - 0.15 11.2 0.0 0.32 10.1 0.0 1.5 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase EPL1 PF10513.9 KOG99796.1 - 7.7e-22 78.4 3.4 7.7e-22 78.4 3.4 4.2 3 1 0 3 3 3 1 Enhancer of polycomb-like Spt20 PF12090.8 KOG99796.1 - 0.057 13.0 59.2 0.03 14.0 39.9 2.5 2 0 0 2 2 2 0 Spt20 family DDHD PF02862.17 KOG99796.1 - 0.45 10.7 25.4 1.3 9.1 15.4 2.5 2 0 0 2 2 2 0 DDHD domain Neur_chan_memb PF02932.16 KOG99796.1 - 0.76 9.8 19.4 0.62 10.1 7.7 2.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region RskA PF10099.9 KOG99796.1 - 2.4 8.4 12.8 6.1 7.1 0.3 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF3835 PF12927.7 KOG99797.1 - 3.3e-18 66.3 0.3 3.3e-18 66.3 0.3 5.9 4 2 1 5 5 5 2 Domain of unknown function (DUF3835) Prefoldin PF02996.17 KOG99797.1 - 5.6e-15 55.3 0.5 2.2e-14 53.4 0.5 2.1 1 0 0 1 1 1 1 Prefoldin subunit tRNA-synt_2d PF01409.20 KOG99798.1 - 7.7e-92 307.2 0.0 1e-91 306.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 KOG99798.1 - 3.2e-13 49.8 1.8 6e-13 48.9 0.4 2.2 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 KOG99798.1 - 5e-08 32.6 0.0 1.3e-05 24.8 0.0 2.3 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain PheRS_DBD2 PF18554.1 KOG99798.1 - 1.1e-06 28.5 2.2 1.1e-06 28.5 2.2 2.2 2 0 0 2 2 2 1 PheRS DNA binding domain 2 tRNA-synt_2 PF00152.20 KOG99798.1 - 5.1e-05 22.5 0.1 0.0016 17.6 0.0 2.8 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 KOG99798.1 - 5.2e-05 23.3 0.0 0.00011 22.3 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_His PF13393.6 KOG99798.1 - 0.011 15.1 0.2 0.042 13.1 0.0 2.0 2 1 1 3 3 3 0 Histidyl-tRNA synthetase GATA PF00320.27 KOG99799.1 - 5.6e-16 57.9 3.5 1.7e-14 53.1 3.1 2.6 2 0 0 2 2 2 1 GATA zinc finger DUF1752 PF08550.10 KOG99799.1 - 1.3e-07 31.4 0.7 3.5e-07 29.9 0.7 1.8 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DUF4668 PF15701.5 KOG99800.1 - 1.3e-16 60.9 0.4 1.5e-16 60.7 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4668) Pyr_redox_2 PF07992.14 KOG99801.1 - 1.9e-66 224.3 5.2 1.9e-66 224.3 5.2 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KOG99801.1 - 2.8e-44 149.9 0.1 9.2e-44 148.2 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOG99801.1 - 1.8e-23 82.9 4.7 9.7e-20 70.9 0.6 3.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOG99801.1 - 1.3e-12 47.7 0.5 8.3e-06 25.9 0.2 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 KOG99801.1 - 2.4e-10 40.4 8.6 5.4e-10 39.2 0.1 2.9 3 1 1 4 4 4 1 FAD dependent oxidoreductase GIDA PF01134.22 KOG99801.1 - 1.1e-09 38.0 1.9 1.1e-09 38.0 1.9 2.5 2 2 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 KOG99801.1 - 2.4e-09 36.9 5.3 3.8e-05 23.1 0.2 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOG99801.1 - 6.2e-08 32.2 1.0 0.0077 15.6 0.0 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 KOG99801.1 - 1.2e-07 31.1 2.1 1.2e-07 31.1 2.1 2.9 2 1 1 3 3 3 1 FAD binding domain HI0933_like PF03486.14 KOG99801.1 - 2.1e-06 26.7 15.3 3.2e-05 22.8 0.9 4.4 4 1 1 5 5 5 3 HI0933-like protein FAD_binding_3 PF01494.19 KOG99801.1 - 1.3e-05 24.7 7.8 0.00079 18.8 0.2 3.4 2 1 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 KOG99801.1 - 4e-05 23.0 0.8 0.0025 17.1 0.0 2.4 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 KOG99801.1 - 0.00023 20.9 16.3 0.083 12.5 2.7 4.2 2 2 2 4 4 4 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 KOG99801.1 - 0.0004 19.7 0.9 0.14 11.3 0.1 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.18 KOG99801.1 - 0.0024 17.8 0.6 0.0024 17.8 0.6 2.9 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 KOG99801.1 - 0.0073 15.6 0.8 0.016 14.6 0.2 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain XdhC_C PF13478.6 KOG99801.1 - 0.0073 16.8 0.0 6.9 7.2 0.0 2.6 2 0 0 2 2 2 2 XdhC Rossmann domain Lycopene_cycl PF05834.12 KOG99801.1 - 0.047 12.7 3.5 0.33 9.9 0.3 2.6 3 0 0 3 3 3 0 Lycopene cyclase protein Trp_halogenase PF04820.14 KOG99801.1 - 0.16 10.8 3.5 0.12 11.2 0.3 2.2 3 0 0 3 3 3 0 Tryptophan halogenase 2-Hacid_dh_C PF02826.19 KOG99801.1 - 0.28 10.5 2.5 2.4 7.5 0.2 2.8 3 1 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Mqo PF06039.15 KOG99801.1 - 0.29 9.6 2.6 0.28 9.7 0.8 1.8 1 1 1 2 2 2 0 Malate:quinone oxidoreductase (Mqo) UDPG_MGDP_dh_N PF03721.14 KOG99801.1 - 0.38 10.3 5.1 1.5 8.3 0.8 2.7 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain LSM PF01423.22 KOG99802.1 - 1.6e-16 59.7 0.0 1.8e-16 59.6 0.0 1.0 1 0 0 1 1 1 1 LSM domain Acetyltransf_1 PF00583.25 KOG99803.1 - 4.1e-17 62.5 0.0 5.1e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOG99803.1 - 9.3e-13 48.4 0.0 1.3e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOG99803.1 - 2.2e-10 40.6 0.0 2.9e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOG99803.1 - 0.00025 21.1 0.0 0.0011 19.1 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 KOG99803.1 - 0.009 16.7 0.0 0.02 15.6 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 KOG99803.1 - 0.012 15.1 0.0 0.058 12.9 0.0 2.0 2 1 0 2 2 2 0 Putative acetyl-transferase SNAP-25 PF00835.19 KOG99803.1 - 0.015 15.6 0.1 0.088 13.1 0.1 2.0 2 0 0 2 2 2 0 SNAP-25 family FR47 PF08445.10 KOG99803.1 - 0.022 14.7 0.0 0.077 13.0 0.0 1.9 1 1 0 1 1 1 0 FR47-like protein Acetyltransf_4 PF13420.7 KOG99803.1 - 0.058 13.5 0.3 0.23 11.6 0.3 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain ETM PF17577.2 KOG99803.1 - 0.059 13.9 0.8 5.1 7.7 0.1 2.1 2 0 0 2 2 2 0 ECORI-T site Acetyltransf_CG PF14542.6 KOG99803.1 - 0.079 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DnaJ_C PF01556.18 KOG99804.1 - 6e-26 91.3 0.1 9.8e-26 90.6 0.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOG99804.1 - 5.8e-25 87.2 5.1 1.3e-24 86.1 5.1 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KOG99804.1 - 2.8e-11 43.6 20.3 5.1e-11 42.8 20.3 1.5 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 KOG99804.1 - 0.05 13.6 8.8 0.073 13.1 1.8 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2318 PF10080.9 KOG99804.1 - 0.6 10.3 6.2 0.17 12.0 0.4 2.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) Cytochrome_C7 PF14522.6 KOG99804.1 - 1.5 8.9 14.0 17 5.5 14.0 2.5 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c Cytochrome_CBB3 PF13442.6 KOG99804.1 - 1.7 9.0 11.6 1.2 9.6 1.0 3.0 1 1 1 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III zinc-ribbons_6 PF07191.12 KOG99804.1 - 8.5 6.4 8.4 1.6 8.8 2.9 2.0 1 1 1 2 2 2 0 zinc-ribbons HSP9_HSP12 PF04119.12 KOG99805.1 - 1.8e-25 89.1 4.0 4.7e-25 87.7 1.5 2.2 2 1 0 2 2 2 1 Heat shock protein 9/12 DUF357 PF04010.13 KOG99805.1 - 0.086 12.9 0.4 1.4 9.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF357) YtxH PF12732.7 KOG99805.1 - 0.6 10.7 6.6 50 4.5 6.6 2.2 1 1 0 1 1 1 0 YtxH-like protein Sugar_tr PF00083.24 KOG99808.1 - 6.3e-171 569.2 34.0 7.2e-171 569.0 34.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOG99808.1 - 1.5e-34 119.4 33.0 9.7e-32 110.2 20.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 KOG99808.1 - 0.0057 15.1 5.7 0.031 12.7 1.9 2.2 2 0 0 2 2 2 2 Transmembrane secretion effector WW PF00397.26 KOG99809.1 - 1.3e-10 41.2 1.1 1.3e-10 41.2 1.1 2.1 2 0 0 2 2 2 1 WW domain Pex14_N PF04695.13 KOG99809.1 - 0.00053 20.7 11.1 0.00081 20.1 11.1 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Med3 PF11593.8 KOG99809.1 - 0.12 11.6 9.1 0.14 11.3 9.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal vMSA PF00695.19 KOG99809.1 - 0.91 8.6 4.5 1.2 8.2 4.5 1.1 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus WD40 PF00400.32 KOG99810.1 - 2.4e-35 119.9 24.2 1.5e-06 28.8 0.6 8.2 9 0 0 9 9 9 6 WD domain, G-beta repeat CDC4_D PF16856.5 KOG99810.1 - 9.3e-21 73.4 0.6 2.2e-20 72.3 0.6 1.6 1 0 0 1 1 1 1 Cell division control protein 4 dimerisation domain F-box-like PF12937.7 KOG99810.1 - 1.3e-08 34.5 0.1 2.9e-08 33.5 0.1 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 KOG99810.1 - 1.2e-06 28.7 1.6 0.85 10.0 0.1 5.4 3 3 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 KOG99810.1 - 5.5e-05 22.9 0.6 0.00014 21.6 0.6 1.8 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.6 KOG99810.1 - 0.01 15.4 1.2 0.11 12.0 0.0 3.0 4 0 0 4 4 4 0 PQQ-like domain SMC_N PF02463.19 KOG99811.1 - 3e-54 183.8 42.2 8.1e-54 182.4 42.2 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KOG99811.1 - 5.5e-24 84.7 0.0 1.8e-23 83.1 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 KOG99811.1 - 3.7e-13 50.4 19.9 3.7e-13 50.4 19.9 6.6 2 2 4 6 6 6 1 AAA domain AAA_21 PF13304.6 KOG99811.1 - 1.7e-10 41.2 8.4 2e-06 27.9 0.6 4.4 4 1 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOG99811.1 - 2.4e-08 33.6 0.1 4.6e-08 32.7 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 KOG99811.1 - 0.00012 21.9 40.1 0.00012 21.9 40.1 4.3 2 2 2 4 4 4 1 AAA ATPase domain ABC_tran PF00005.27 KOG99811.1 - 0.086 13.4 0.1 0.086 13.4 0.1 6.2 4 3 0 4 4 4 0 ABC transporter FUSC PF04632.12 KOG99811.1 - 0.46 9.0 3.1 1.1 7.7 3.1 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein family BLM10_mid PF16507.5 KOG99812.1 - 9.9e-171 568.9 13.8 9.9e-171 568.9 13.8 1.7 2 0 0 2 2 2 1 Proteasome-substrate-size regulator, mid region BLM10_N PF16547.5 KOG99812.1 - 2.6e-33 114.1 1.0 9.2e-33 112.4 0.3 2.3 2 0 0 2 2 2 1 Proteasome-substrate-size regulator, N-terminal DUF3437 PF11919.8 KOG99812.1 - 1.1e-26 92.6 0.0 9.7e-26 89.5 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) HEAT PF02985.22 KOG99812.1 - 0.1 12.9 0.0 4.8 7.7 0.0 3.1 2 0 0 2 2 2 0 HEAT repeat Ras PF00071.22 KOG99813.1 - 1.8e-63 213.0 0.4 2.2e-63 212.7 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG99813.1 - 3.3e-37 127.4 0.3 6e-37 126.5 0.3 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG99813.1 - 5e-19 68.4 0.1 6.2e-19 68.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KOG99813.1 - 1.3e-07 31.2 0.2 1.6e-07 30.9 0.2 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KOG99813.1 - 6.1e-07 29.0 0.1 6.9e-07 28.8 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOG99813.1 - 1.7e-06 28.1 0.1 2.7e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG99813.1 - 1.6e-05 24.9 0.8 0.1 12.5 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KOG99813.1 - 1.8e-05 24.4 0.4 0.00036 20.1 0.2 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KOG99813.1 - 0.0023 17.5 0.3 0.022 14.3 0.3 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B MCM PF00493.23 KOG99813.1 - 0.013 14.6 0.1 0.045 12.8 0.0 1.8 2 1 0 2 2 2 0 MCM P-loop domain AAA_7 PF12775.7 KOG99813.1 - 0.021 14.3 0.1 0.046 13.2 0.1 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 KOG99813.1 - 0.03 14.6 0.1 0.15 12.3 0.0 2.3 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.6 KOG99813.1 - 0.052 13.3 2.0 0.16 11.7 0.8 2.4 1 1 1 2 2 2 0 P-loop containing region of AAA domain AAA PF00004.29 KOG99813.1 - 0.07 13.6 0.1 0.9 10.0 0.0 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOG99813.1 - 0.1 13.0 0.0 0.14 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain DUF4938 PF16292.5 KOG99813.1 - 0.11 11.8 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4938) VTC PF09359.10 KOG99814.1 - 2.2e-97 325.7 0.4 2.2e-97 325.7 0.4 2.1 3 0 0 3 3 3 1 VTC domain DUF202 PF02656.15 KOG99814.1 - 3.4e-11 43.4 0.6 3.4e-11 43.4 0.6 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 KOG99814.1 - 6.7e-11 42.7 27.2 0.00059 19.9 1.6 4.5 2 1 2 4 4 4 4 SPX domain MBOAT PF03062.19 KOG99814.1 - 0.00062 19.2 1.1 0.0012 18.3 1.1 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family CYTH PF01928.21 KOG99814.1 - 0.018 15.0 0.1 0.043 13.8 0.1 1.6 1 0 0 1 1 1 0 CYTH domain CPSase_L_D3 PF02787.19 KOG99814.1 - 0.066 13.6 1.6 0.23 11.8 0.1 2.4 2 0 0 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain MutS_V PF00488.21 KOG99815.1 - 4.2e-58 196.5 0.5 1.2e-57 195.0 0.2 2.0 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 KOG99815.1 - 5.2e-30 105.1 7.0 5.2e-30 105.1 7.0 2.7 3 0 0 3 3 3 1 MutS domain III MutS_II PF05188.17 KOG99815.1 - 5.3e-22 78.6 0.2 5.3e-22 78.6 0.2 2.0 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 KOG99815.1 - 1.3e-16 60.7 1.0 5.4e-16 58.7 1.0 2.2 1 0 0 1 1 1 1 MutS family domain IV DEAD PF00270.29 KOG99816.1 - 3e-40 137.9 0.0 5.5e-40 137.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOG99816.1 - 3.1e-24 85.4 0.1 3.9e-23 81.9 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KOG99816.1 - 3.6e-18 65.5 0.1 9.9e-18 64.1 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KOG99816.1 - 5e-06 26.6 2.0 0.00045 20.3 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOG99816.1 - 5.4e-05 22.5 0.0 5.4e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Ntox21 PF15526.6 KOG99816.1 - 0.12 12.7 0.9 0.28 11.5 0.4 1.9 2 0 0 2 2 2 0 Novel toxin 21 PseudoU_synth_1 PF01416.20 KOG99817.1 - 1.2e-32 112.6 0.0 1.7e-29 102.4 0.0 2.9 2 1 1 3 3 3 2 tRNA pseudouridine synthase JIP_LZII PF16471.5 KOG99817.1 - 0.056 13.6 0.4 0.11 12.6 0.4 1.4 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II Sec62 PF03839.16 KOG99817.1 - 0.07 12.6 1.3 0.13 11.8 1.3 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 PIN_6 PF17146.4 KOG99818.1 - 0.56 10.7 5.1 4.3 7.9 0.1 2.5 2 1 0 2 2 2 0 PIN domain of ribonuclease Nic96 PF04097.14 KOG99819.1 - 6e-195 649.3 5.9 9.2e-195 648.7 5.9 1.2 1 0 0 1 1 1 1 Nup93/Nic96 HHH_4 PF14490.6 KOG99819.1 - 0.0076 16.2 0.1 0.27 11.2 0.0 2.9 3 0 0 3 3 3 1 Helix-hairpin-helix containing domain PPI_Ypi1 PF07491.11 KOG99820.1 - 2.9e-22 78.2 13.7 1.1e-21 76.4 13.7 2.0 1 1 0 1 1 1 1 Protein phosphatase inhibitor SR-25 PF10500.9 KOG99820.1 - 0.018 14.7 15.4 0.023 14.3 15.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 KOG99820.1 - 9.3 4.4 14.0 11 4.2 14.0 1.2 1 0 0 1 1 1 0 CDC45-like protein JAB PF01398.21 KOG99821.1 - 6.5e-32 110.0 0.2 6.5e-32 110.0 0.2 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 KOG99821.1 - 6.6e-11 42.6 1.6 1.6e-10 41.4 1.6 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 KOG99821.1 - 2.6e-07 30.4 0.0 4.2e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF4138 PF13595.6 KOG99821.1 - 0.028 13.7 1.0 0.054 12.8 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4138) UPF0172 PF03665.13 KOG99821.1 - 0.089 12.8 2.0 0.2 11.7 0.0 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0172) UCH PF00443.29 KOG99822.1 - 6e-08 32.5 0.1 1.5e-07 31.2 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KOG99822.1 - 8.7e-08 32.4 4.7 2.2e-07 31.1 4.7 1.7 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein GHD PF17834.1 KOG99822.1 - 0.086 12.9 0.2 0.26 11.3 0.0 1.9 2 0 0 2 2 2 0 Beta-sandwich domain in beta galactosidase Peptidase_M24 PF00557.24 KOG99823.1 - 7.2e-60 202.3 0.0 9.9e-60 201.8 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 KOG99823.1 - 7.6e-22 77.3 0.0 2.3e-21 75.8 0.0 2.0 1 1 0 1 1 1 1 Aminopeptidase P, N-terminal domain AAA_16 PF13191.6 KOG99824.1 - 1e-06 29.3 0.0 1.7e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 KOG99824.1 - 0.00013 21.9 0.0 0.0005 20.1 0.0 2.0 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 KOG99824.1 - 0.00033 20.0 0.0 0.00057 19.2 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 KOG99824.1 - 0.00035 20.8 0.0 0.0017 18.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain PRK PF00485.18 KOG99824.1 - 0.00045 20.0 0.0 0.93 9.2 0.0 2.4 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family 6PF2K PF01591.18 KOG99824.1 - 0.0027 17.0 0.0 0.0046 16.3 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase KTI12 PF08433.10 KOG99824.1 - 0.0035 16.8 0.0 0.0056 16.2 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 KOG99824.1 - 0.0049 17.4 0.0 0.01 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KOG99824.1 - 0.0058 17.0 0.0 0.011 16.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase NB-ARC PF00931.22 KOG99824.1 - 0.0066 15.7 0.0 0.013 14.6 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 KOG99824.1 - 0.0078 16.5 0.0 0.02 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Microtub_bd PF16796.5 KOG99824.1 - 0.01 15.8 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 Microtubule binding AAA PF00004.29 KOG99824.1 - 0.012 16.0 0.0 0.025 15.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOG99824.1 - 0.025 14.3 0.0 0.057 13.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 KOG99824.1 - 0.033 13.2 0.0 0.065 12.2 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 KOG99824.1 - 0.034 14.4 0.0 0.065 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOG99824.1 - 0.038 13.5 0.0 0.11 12.0 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region RuvB_N PF05496.12 KOG99824.1 - 0.042 13.6 0.0 0.087 12.6 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 KOG99824.1 - 0.045 13.5 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 KOG99824.1 - 0.061 13.8 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.6 KOG99824.1 - 0.062 13.7 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KOG99824.1 - 0.065 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Ploopntkinase3 PF18751.1 KOG99824.1 - 0.071 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 MMR_HSR1 PF01926.23 KOG99824.1 - 0.077 13.1 0.0 0.27 11.3 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.12 KOG99824.1 - 0.082 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain TrwB_AAD_bind PF10412.9 KOG99824.1 - 0.11 11.4 0.0 0.23 10.3 0.0 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_24 PF13479.6 KOG99824.1 - 0.12 12.1 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 KOG99824.1 - 0.12 12.3 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 NTPase AAA_19 PF13245.6 KOG99824.1 - 0.12 12.7 0.0 0.28 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 KOG99824.1 - 0.15 11.1 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF3987 PF13148.6 KOG99824.1 - 0.15 11.0 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) GTSE1_N PF15259.6 KOG99825.1 - 0.23 11.6 7.2 0.038 14.2 1.5 2.2 2 1 1 3 3 3 0 G-2 and S-phase expressed 1 FAM195 PF14799.6 KOG99825.1 - 0.82 10.0 8.1 1.7 9.0 2.1 2.4 2 1 0 2 2 2 0 FAM195 family SIR2 PF02146.17 KOG99825.1 - 4.8 7.1 8.1 1.8 8.4 2.6 2.3 2 1 0 2 2 2 0 Sir2 family Plasmodium_HRP PF05403.11 KOG99826.1 - 4e-05 23.5 9.0 4e-05 23.5 9.0 2.2 1 1 1 2 2 2 1 Plasmodium histidine-rich protein (HRPII/III) SH3BGR PF04908.15 KOG99827.1 - 0.033 14.3 0.1 0.18 12.0 0.0 2.3 2 1 1 3 3 3 0 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 KOG99827.1 - 0.036 14.3 0.0 0.11 12.7 0.0 1.9 1 0 0 1 1 1 0 Glutaredoxin Inhibitor_I69 PF13734.6 KOG99827.1 - 0.22 11.9 0.1 0.22 11.9 0.1 3.0 3 0 0 3 3 3 0 Spi protease inhibitor Glycogen_syn PF05693.13 KOG99828.1 - 0 1164.1 0.0 0 1163.9 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 KOG99828.1 - 3.9e-09 36.3 0.0 5.2e-07 29.4 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOG99828.1 - 1.1e-06 29.1 0.0 0.00066 20.1 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KOG99828.1 - 0.00014 21.9 0.4 0.00031 20.8 0.1 1.8 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.11 KOG99828.1 - 0.00042 20.1 0.0 0.00081 19.2 0.0 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_4 PF13579.6 KOG99828.1 - 0.0025 18.3 0.1 0.0048 17.4 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Pkinase PF00069.25 KOG99829.1 - 8.8e-71 238.4 0.1 1.6e-70 237.5 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOG99829.1 - 2.1e-38 132.1 0.0 2.9e-38 131.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOG99829.1 - 3e-06 26.7 0.0 0.02 14.2 0.0 2.3 1 1 0 2 2 2 2 Kinase-like WHIM1 PF15612.6 KOG99830.1 - 6.1e-05 22.5 0.0 0.0002 20.8 0.0 1.9 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 Ribosomal_S21 PF01165.20 KOG99830.1 - 0.024 14.3 0.3 0.28 11.0 0.1 2.6 2 0 0 2 2 2 0 Ribosomal protein S21 Astro_capsid_p PF12226.8 KOG99830.1 - 0.49 9.5 15.2 0.93 8.6 15.2 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein SUR7 PF06687.12 KOG99831.1 - 7.1e-11 42.1 18.5 7.1e-11 42.1 18.5 1.6 2 0 0 2 2 2 1 SUR7/PalI family TspO_MBR PF03073.15 KOG99831.1 - 0.037 14.1 5.3 0.087 12.9 5.3 1.6 1 0 0 1 1 1 0 TspO/MBR family Virul_fac_BrkB PF03631.15 KOG99831.1 - 0.088 12.4 5.3 0.26 10.8 5.5 1.6 1 1 0 1 1 1 0 Virulence factor BrkB DUF1690 PF07956.11 KOG99832.1 - 5.3e-42 143.5 7.9 7.6e-42 143.0 7.9 1.2 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) DUF4747 PF15931.5 KOG99832.1 - 0.0061 16.3 1.4 0.0097 15.6 1.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4747) STN1_2 PF09170.10 KOG99832.1 - 0.34 11.1 4.4 0.49 10.6 4.4 1.3 1 1 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 UCH PF00443.29 KOG99833.1 - 8.6e-49 166.3 6.5 1.2e-48 165.8 6.5 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOG99833.1 - 5.9e-11 42.5 15.3 8.7e-10 38.7 15.3 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 KOG99833.1 - 4.6e-05 23.1 0.4 0.00057 19.6 0.0 2.7 2 0 0 2 2 2 1 Ubiquitin family Phage_Gp23 PF10669.9 KOG99833.1 - 1.8 8.9 8.9 0.75 10.1 3.7 2.4 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) ABC_tran PF00005.27 KOG99834.1 - 1.3e-47 161.8 0.2 3.3e-23 82.7 0.0 3.1 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 KOG99834.1 - 3.1e-19 68.8 9.2 3.1e-19 68.8 9.2 2.2 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 KOG99834.1 - 4.8e-15 56.2 15.0 7.3e-05 22.7 0.0 5.4 3 2 1 6 6 5 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOG99834.1 - 1.3e-10 41.1 0.0 0.0017 17.8 0.0 3.5 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 KOG99834.1 - 3.1e-07 30.8 1.0 0.033 14.4 0.1 3.1 3 1 0 3 3 2 2 AAA domain AAA_16 PF13191.6 KOG99834.1 - 8.8e-07 29.5 0.0 0.075 13.4 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 KOG99834.1 - 2.2e-06 28.0 0.3 0.13 12.5 0.1 3.6 3 1 0 3 3 3 2 AAA domain AAA_29 PF13555.6 KOG99834.1 - 2.6e-06 27.1 0.0 0.13 12.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOG99834.1 - 5.3e-06 26.4 0.0 0.076 12.9 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 KOG99834.1 - 7.1e-06 26.6 3.2 0.081 13.5 0.1 4.1 5 0 0 5 5 3 2 AAA domain AAA_15 PF13175.6 KOG99834.1 - 7.3e-06 25.9 19.9 0.014 15.2 0.0 4.8 4 1 0 4 4 4 2 AAA ATPase domain NACHT PF05729.12 KOG99834.1 - 7.6e-06 25.9 0.2 0.045 13.7 0.0 2.7 2 1 0 2 2 2 2 NACHT domain MMR_HSR1 PF01926.23 KOG99834.1 - 3.2e-05 24.0 0.3 0.097 12.8 0.2 3.1 2 1 0 2 2 2 2 50S ribosome-binding GTPase AAA_14 PF13173.6 KOG99834.1 - 4.1e-05 23.6 0.1 0.52 10.3 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA PF00004.29 KOG99834.1 - 5.5e-05 23.6 0.0 0.16 12.4 0.0 3.4 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KOG99834.1 - 0.00017 21.8 0.1 0.28 11.4 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.6 KOG99834.1 - 0.00025 21.6 25.9 0.12 12.9 0.0 5.2 5 0 0 5 5 5 2 AAA domain AAA_24 PF13479.6 KOG99834.1 - 0.00029 20.6 0.0 0.86 9.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain ATP-synt_ab PF00006.25 KOG99834.1 - 0.00036 20.3 0.0 0.1 12.2 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain RNA_helicase PF00910.22 KOG99834.1 - 0.00038 20.8 1.0 0.4 11.1 0.0 3.3 4 0 0 4 4 2 1 RNA helicase PduV-EutP PF10662.9 KOG99834.1 - 0.00044 20.0 0.2 0.44 10.3 0.1 2.9 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 KOG99834.1 - 0.001 18.6 0.0 0.48 9.9 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Roc PF08477.13 KOG99834.1 - 0.0016 18.7 0.0 2.2 8.5 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 KOG99834.1 - 0.0018 17.3 0.0 0.28 10.1 0.0 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB TsaE PF02367.17 KOG99834.1 - 0.0019 18.2 0.0 0.53 10.3 0.0 2.7 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 KOG99834.1 - 0.002 18.1 0.0 3.8 7.5 0.0 2.8 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 KOG99834.1 - 0.0021 17.8 0.0 0.53 10.0 0.0 3.2 3 1 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 KOG99834.1 - 0.0022 17.3 0.0 0.56 9.5 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin NB-ARC PF00931.22 KOG99834.1 - 0.0024 17.1 0.6 0.7 9.0 0.0 2.7 2 1 0 2 2 2 1 NB-ARC domain NTPase_1 PF03266.15 KOG99834.1 - 0.0026 17.7 0.0 0.79 9.6 0.0 2.6 2 0 0 2 2 2 1 NTPase ATPase_2 PF01637.18 KOG99834.1 - 0.0068 16.3 2.2 1.7 8.5 0.0 3.0 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea DUF815 PF05673.13 KOG99834.1 - 0.0072 15.5 0.0 3.6 6.7 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Septin PF00735.18 KOG99834.1 - 0.012 14.9 0.5 3.6 6.8 0.1 2.8 2 1 0 2 2 2 0 Septin MobB PF03205.14 KOG99834.1 - 0.013 15.4 0.0 0.34 10.8 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Pox_A32 PF04665.12 KOG99834.1 - 0.017 14.6 1.4 0.91 8.9 0.0 3.1 3 0 0 3 3 3 0 Poxvirus A32 protein AAA_25 PF13481.6 KOG99834.1 - 0.023 14.3 0.0 1.9 8.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 KOG99834.1 - 0.023 13.9 5.5 0.35 10.0 0.0 3.0 3 0 0 3 3 3 0 G-protein alpha subunit FeoB_N PF02421.18 KOG99834.1 - 0.025 14.1 0.0 8.3 5.9 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_27 PF13514.6 KOG99834.1 - 0.025 14.1 0.3 13 5.3 0.0 3.4 2 1 1 3 3 3 0 AAA domain SbcCD_C PF13558.6 KOG99834.1 - 0.032 14.5 0.1 26 5.1 0.0 3.4 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 KOG99834.1 - 0.032 13.9 0.0 2.1 7.9 0.1 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Arf PF00025.21 KOG99834.1 - 0.056 12.9 0.0 0.73 9.3 0.0 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family DUF2813 PF11398.8 KOG99834.1 - 0.056 12.7 7.2 0.25 10.6 0.0 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF2813) cobW PF02492.19 KOG99834.1 - 0.061 12.9 0.2 6.1 6.4 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.9 KOG99834.1 - 0.064 12.2 0.1 0.27 10.1 0.0 1.9 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Ras PF00071.22 KOG99834.1 - 0.099 12.2 0.5 13 5.4 0.0 3.0 3 0 0 3 3 3 0 Ras family Viral_helicase1 PF01443.18 KOG99834.1 - 0.11 12.2 0.0 3.4 7.3 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Dynamin_N PF00350.23 KOG99834.1 - 0.15 12.1 8.4 0.13 12.3 0.2 3.5 3 1 0 4 4 3 0 Dynamin family AAA_17 PF13207.6 KOG99834.1 - 1.4 9.4 6.9 19 5.6 0.1 3.8 3 1 1 4 4 3 0 AAA domain Troponin-I_N PF11636.8 KOG99835.1 - 1.1 9.2 16.6 6.2 6.9 0.3 3.9 3 0 0 3 3 3 0 Troponin I residues 1-32 Peptidase_M28 PF04389.17 KOG99836.1 - 1.2e-45 155.6 0.0 1.9e-45 155.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PIP5K PF01504.18 KOG99837.1 - 3.7e-41 141.2 3.6 3.1e-36 125.0 2.2 4.1 2 2 1 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 KOG99837.1 - 7.2e-25 87.6 0.0 1.3e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 KOG99837.1 - 1.7e-15 56.9 15.0 4.8e-15 55.4 15.0 1.9 1 0 0 1 1 1 1 FYVE zinc finger WD40 PF00400.32 KOG99838.1 - 1.6e-06 28.7 0.0 0.097 13.6 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOG99838.1 - 1e-05 25.8 0.0 0.18 12.1 0.0 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain CNH PF00780.22 KOG99838.1 - 0.04 13.5 0.0 0.18 11.4 0.0 1.9 2 1 0 2 2 2 0 CNH domain Ge1_WD40 PF16529.5 KOG99838.1 - 0.15 11.0 0.2 0.59 9.0 0.1 1.9 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Arrestin_C PF02752.22 KOG99839.1 - 1.3e-24 87.2 0.1 4.1e-24 85.5 0.0 2.0 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 KOG99839.1 - 4.6e-09 36.5 0.0 4.1e-08 33.4 0.0 2.2 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 KOG99839.1 - 0.0012 18.6 0.0 0.0025 17.6 0.0 1.5 1 0 0 1 1 1 1 Arrestin_N terminal like RRM_1 PF00076.22 KOG99840.1 - 1.3e-50 169.1 11.2 1.4e-19 69.7 0.1 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KOG99840.1 - 1.7e-06 28.0 0.8 8.7 6.5 0.1 4.9 4 1 0 4 4 4 3 Limkain b1 RRM_3 PF08777.11 KOG99840.1 - 7.5e-06 25.9 2.8 4.4 7.4 0.2 4.7 4 1 0 4 4 4 3 RNA binding motif RRM_occluded PF16842.5 KOG99840.1 - 8.7e-06 25.5 0.0 0.93 9.4 0.0 3.6 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 KOG99840.1 - 3.7e-05 23.3 0.3 0.04 13.5 0.0 3.4 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KOG99840.1 - 4.2e-05 23.5 2.5 0.0025 17.8 0.0 3.6 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif RRM_Rrp7 PF17799.1 KOG99840.1 - 0.00045 20.1 2.5 0.0049 16.7 0.1 3.3 4 0 0 4 4 4 1 Rrp7 RRM-like N-terminal domain SET_assoc PF11767.8 KOG99840.1 - 0.011 15.3 1.8 21 4.9 0.1 3.6 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated Cas_NE0113 PF09623.10 KOG99840.1 - 0.14 11.9 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 CRISPR-associated protein NE0113 (Cas_NE0113) Ysc84 PF04366.12 KOG99841.1 - 1.4e-41 141.2 0.1 2.5e-41 140.4 0.1 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 KOG99841.1 - 4.6e-17 61.4 0.0 9.9e-17 60.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOG99841.1 - 1.3e-12 47.4 1.7 1.3e-12 47.4 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 KOG99841.1 - 5.4e-12 45.2 0.0 1.2e-11 44.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PHP PF02811.19 KOG99842.1 - 1.8e-10 41.4 0.0 2.9e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 PHP domain Acetyltransf_13 PF13880.6 KOG99843.1 - 2.2e-22 78.8 0.0 6.5e-22 77.3 0.0 1.7 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 KOG99843.1 - 3.6e-11 42.7 0.3 6.4e-11 41.9 0.3 1.4 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_7 PF13508.7 KOG99843.1 - 0.012 16.0 0.1 0.04 14.3 0.1 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOG99843.1 - 0.047 13.9 0.0 0.092 13.0 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family BIR PF00653.21 KOG99843.1 - 0.069 13.8 0.1 0.14 12.9 0.1 1.4 1 0 0 1 1 1 0 Inhibitor of Apoptosis domain ECH_1 PF00378.20 KOG99843.1 - 0.097 12.0 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase DSPn PF14671.6 KOG99844.1 - 6.4e-46 156.3 0.1 1.6e-45 155.0 0.1 1.7 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 KOG99844.1 - 1.3e-26 93.0 0.0 1.3e-25 89.8 0.0 2.4 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOG99844.1 - 0.00049 19.7 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 KOG99844.1 - 0.00087 19.0 0.6 0.0019 17.9 0.1 1.7 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 KOG99844.1 - 0.027 14.6 0.0 0.059 13.5 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate FAD_binding_1 PF00667.20 KOG99846.1 - 7.3e-76 254.6 0.0 1.5e-75 253.6 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 KOG99846.1 - 5.7e-08 33.4 0.0 1.6e-07 31.9 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOG99846.1 - 0.079 13.3 0.0 0.5 10.7 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain PFOR_II PF17147.4 KOG99846.1 - 0.15 12.4 0.0 0.39 11.1 0.0 1.7 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II SMC_N PF02463.19 KOG99847.1 - 5.9e-71 238.4 11.5 2.1e-69 233.3 11.5 2.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KOG99847.1 - 1.4e-23 83.4 0.0 4.2e-23 81.9 0.0 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 KOG99847.1 - 4.6e-16 59.9 1.9 4.6e-16 59.9 1.9 6.9 2 2 2 4 4 4 1 AAA domain AAA_15 PF13175.6 KOG99847.1 - 1.3e-13 51.5 0.7 1.3e-13 51.5 0.7 4.3 2 2 2 4 4 4 1 AAA ATPase domain AAA_21 PF13304.6 KOG99847.1 - 6.2e-07 29.5 18.9 6.1e-05 23.0 0.3 3.9 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system GAS PF13851.6 KOG99847.1 - 8e-06 25.3 22.9 0.00021 20.7 1.9 7.9 3 2 5 8 8 8 3 Growth-arrest specific micro-tubule binding AAA_29 PF13555.6 KOG99847.1 - 5.1e-05 22.9 0.1 0.00013 21.7 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Hema_HEFG PF02710.14 KOG99847.1 - 0.0065 16.7 0.0 0.017 15.3 0.0 1.7 1 0 0 1 1 1 1 Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein ABC_tran PF00005.27 KOG99847.1 - 0.58 10.7 0.0 0.58 10.7 0.0 6.2 3 2 0 3 3 3 0 ABC transporter DUF3866 PF12982.7 KOG99847.1 - 1.5 7.8 4.4 7 5.7 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3866) Ribosomal_L2_C PF03947.18 KOG99848.1 - 0.00017 21.8 2.4 0.00022 21.4 2.4 1.3 1 1 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain RRM_1 PF00076.22 KOG99849.1 - 6e-15 54.8 0.0 1.4e-09 37.7 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOG99849.1 - 4.5e-05 23.2 0.2 0.38 10.6 0.1 2.8 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_7 PF16367.5 KOG99849.1 - 0.00012 22.2 0.0 0.071 13.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif PHM7_cyt PF14703.6 KOG99849.1 - 0.032 14.5 0.3 3.9 7.7 0.1 3.4 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Ribosomal_L29e PF01779.17 KOG99850.1 - 6.8e-24 83.9 9.4 8.9e-24 83.5 9.4 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family UCR_hinge PF02320.16 KOG99851.1 - 8.7e-23 80.3 5.2 1.6e-22 79.5 5.2 1.4 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Sigma70_ner PF04546.13 KOG99851.1 - 0.00016 21.6 15.6 0.00018 21.5 15.6 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region DNA_pol_phi PF04931.13 KOG99851.1 - 0.0064 14.7 27.6 0.0068 14.6 27.6 1.1 1 0 0 1 1 1 1 DNA polymerase phi Nop14 PF04147.12 KOG99851.1 - 0.012 13.9 22.4 0.013 13.8 22.4 1.0 1 0 0 1 1 1 0 Nop14-like family RPN2_C PF18004.1 KOG99851.1 - 0.019 14.9 8.0 0.023 14.6 8.0 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain RAB3GAP2_C PF14656.6 KOG99851.1 - 0.019 13.2 2.9 0.025 12.8 2.9 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus Mpp10 PF04006.12 KOG99851.1 - 0.038 12.5 20.9 0.043 12.3 20.9 1.0 1 0 0 1 1 1 0 Mpp10 protein CDC45 PF02724.14 KOG99851.1 - 0.07 11.4 14.1 0.073 11.4 14.1 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.14 KOG99851.1 - 0.17 12.3 5.6 0.26 11.7 5.6 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Cwf_Cwc_15 PF04889.12 KOG99851.1 - 0.18 11.5 22.4 0.23 11.2 22.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RRN3 PF05327.11 KOG99851.1 - 0.48 8.9 15.5 0.49 8.9 15.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PDDEXK_6 PF04720.12 KOG99851.1 - 0.5 10.3 8.5 0.58 10.1 8.5 1.1 1 0 0 1 1 1 0 PDDEXK-like family of unknown function DUF913 PF06025.12 KOG99851.1 - 0.52 9.2 3.5 0.51 9.3 3.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CobT PF06213.12 KOG99851.1 - 0.99 8.7 19.2 1.1 8.6 19.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT BUD22 PF09073.10 KOG99851.1 - 2.4 7.4 20.9 2.7 7.2 20.9 1.0 1 0 0 1 1 1 0 BUD22 TRAP_alpha PF03896.16 KOG99851.1 - 2.8 7.1 12.7 3.2 6.9 12.7 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Presenilin PF01080.17 KOG99851.1 - 2.8 6.6 4.9 3.1 6.5 4.9 1.0 1 0 0 1 1 1 0 Presenilin GCIP PF13324.6 KOG99851.1 - 2.9 7.4 10.1 3.8 7.0 10.1 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Myc_N PF01056.18 KOG99851.1 - 3.7 7.3 10.8 5.1 6.9 10.8 1.2 1 0 0 1 1 1 0 Myc amino-terminal region YL1 PF05764.13 KOG99851.1 - 4.5 7.3 23.5 5 7.2 23.5 1.1 1 0 0 1 1 1 0 YL1 nuclear protein DUF2428 PF10350.9 KOG99851.1 - 5 6.3 7.4 6.1 6.0 7.1 1.3 1 1 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) GEMIN8 PF15348.6 KOG99851.1 - 7.8 6.7 14.6 9.6 6.4 14.6 1.2 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 SDA1 PF05285.12 KOG99851.1 - 8.3 5.7 25.9 9.4 5.6 25.9 1.1 1 0 0 1 1 1 0 SDA1 CRA PF06589.11 KOG99851.1 - 9.3 6.4 7.4 14 5.8 7.4 1.3 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) Pinin_SDK_memA PF04696.13 KOG99852.1 - 0.18 11.9 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region NOA36 PF06524.12 KOG99852.1 - 5.6 6.2 9.5 8.3 5.6 9.5 1.2 1 0 0 1 1 1 0 NOA36 protein ANAPC_CDC26 PF10471.9 KOG99854.1 - 5.9e-10 39.8 6.7 1.4e-09 38.7 6.7 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 SWIRM PF04433.17 KOG99855.1 - 7.9e-28 96.6 0.2 2.4e-27 95.1 0.2 1.9 1 0 0 1 1 1 1 SWIRM domain ZZ PF00569.17 KOG99855.1 - 1.2e-17 63.5 3.5 1.9e-17 62.8 3.5 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 KOG99855.1 - 2.8e-09 37.0 0.1 6.6e-09 35.8 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM-assoc_1 PF16495.5 KOG99855.1 - 4.4e-08 33.0 8.0 9.8e-08 31.9 8.0 1.6 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-bind_6 PF13921.6 KOG99855.1 - 1.7e-06 28.2 1.7 6.4e-06 26.3 0.1 2.8 4 0 0 4 4 4 1 Myb-like DNA-binding domain zf-UBR PF02207.20 KOG99855.1 - 0.007 16.5 0.8 0.014 15.5 0.8 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-CCHC_2 PF13696.6 KOG99855.1 - 0.0088 15.8 2.9 0.55 10.1 0.1 2.5 2 0 0 2 2 2 2 Zinc knuckle Elf1 PF05129.13 KOG99855.1 - 0.058 13.5 0.3 0.15 12.1 0.3 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like SNF2_N PF00176.23 KOG99856.1 - 2.3e-69 233.8 0.2 3.7e-69 233.1 0.2 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOG99856.1 - 4.7e-19 68.8 0.0 2.5e-18 66.5 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOG99856.1 - 1.7e-08 34.6 0.0 1.7e-08 34.6 0.0 2.6 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOG99856.1 - 6e-07 29.4 0.0 1.4e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 KOG99856.1 - 0.00086 18.6 0.1 0.00086 18.6 0.1 2.2 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase ING PF12998.7 KOG99857.1 - 0.12 12.9 0.2 0.12 12.9 0.2 2.9 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding Pox_Ag35 PF03286.14 KOG99857.1 - 0.79 9.5 4.5 0.58 9.9 2.6 1.8 2 0 0 2 2 2 0 Pox virus Ag35 surface protein SAPS PF04499.15 KOG99858.1 - 1.9e-177 590.9 11.4 1.9e-177 590.9 11.4 3.9 3 1 0 3 3 3 1 SIT4 phosphatase-associated protein DnaJ PF00226.31 KOG99859.1 - 3.9e-14 52.5 2.2 7.6e-14 51.6 2.2 1.5 1 0 0 1 1 1 1 DnaJ domain RNA_pol_Rbc25 PF08292.12 KOG99859.1 - 0.015 15.5 0.2 0.03 14.6 0.2 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 Adaptin_binding PF10199.9 KOG99861.1 - 3.6e-06 27.6 2.6 0.03 14.9 0.1 2.4 1 1 1 2 2 2 2 Alpha and gamma adaptin binding protein p34 NKWYS PF10364.9 KOG99861.1 - 0.028 14.6 0.2 0.074 13.2 0.2 1.8 1 0 0 1 1 1 0 Putative capsular polysaccharide synthesis protein Peptidase_M20 PF01546.28 KOG99862.1 - 5.7e-29 101.3 0.0 7.6e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KOG99862.1 - 9.7e-12 44.8 0.0 1.6e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 KOG99862.1 - 0.045 13.4 0.0 0.081 12.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 Mito_carr PF00153.27 KOG99863.1 - 4.7e-36 122.6 7.7 2.4e-17 62.6 1.2 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein TetR_C_22 PF17928.1 KOG99864.1 - 0.063 13.6 0.2 0.22 11.8 0.0 1.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Radial_spoke PF04712.12 KOG99864.1 - 0.093 11.7 13.2 0.022 13.7 4.6 2.3 2 0 0 2 2 2 0 Radial spokehead-like protein RXT2_N PF08595.11 KOG99864.1 - 0.28 11.2 13.2 0.29 11.2 3.8 2.7 2 0 0 2 2 2 0 RXT2-like, N-terminal Ribosomal_60s PF00428.19 KOG99864.1 - 0.53 10.9 11.9 1.4 9.5 11.9 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein PBP_sp32 PF07222.12 KOG99864.1 - 2.3 7.6 7.3 4.5 6.7 7.3 1.5 1 0 0 1 1 1 0 Proacrosin binding protein sp32 MRNIP PF15749.5 KOG99864.1 - 5.8 7.7 9.5 7.7 7.3 1.0 2.5 2 0 0 2 2 2 0 MRN-interacting protein Menin PF05053.13 KOG99864.1 - 7.8 4.7 9.9 0.13 10.6 2.2 1.7 2 0 0 2 2 2 0 Menin QRPTase_C PF01729.19 KOG99865.1 - 4.8e-60 202.2 0.0 5.9e-60 201.9 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 KOG99865.1 - 4.1e-18 65.2 0.0 1.2e-17 63.8 0.0 1.8 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain DUF155 PF02582.14 KOG99866.1 - 3.6e-52 177.0 0.2 7.5e-52 176.0 0.2 1.6 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 S36_mt PF10937.8 KOG99867.1 - 3.4e-28 99.5 0.1 4.4e-28 99.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial Proteasome PF00227.26 KOG99868.1 - 1.2e-23 83.6 0.0 1.6e-23 83.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Clat_adaptor_s PF01217.20 KOG99869.1 - 1.5e-08 34.7 2.3 2.9e-08 33.8 2.3 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Adap_comp_sub PF00928.21 KOG99869.1 - 5.1e-08 32.6 0.0 7.6e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family muHD PF10291.9 KOG99869.1 - 0.013 15.0 0.0 0.043 13.3 0.0 1.8 1 1 0 1 1 1 0 Muniscin C-terminal mu homology domain AAA_assoc PF14363.6 KOG99869.1 - 0.058 13.7 0.4 0.23 11.8 0.4 2.1 1 0 0 1 1 1 0 Domain associated at C-terminal with AAA CDC37_N PF03234.14 KOG99869.1 - 0.15 13.0 2.9 0.77 10.7 0.1 2.5 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding CSN8_PSD8_EIF3K PF10075.9 KOG99870.1 - 9.2e-20 71.1 3.7 1.7e-19 70.3 3.7 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 KOG99870.1 - 0.00043 19.8 0.3 0.0006 19.3 0.3 1.2 1 0 0 1 1 1 1 SAC3/GANP family Hexokinase_2 PF03727.16 KOG99871.1 - 8.4e-78 261.1 0.0 2.2e-77 259.7 0.0 1.7 2 0 0 2 2 2 1 Hexokinase Hexokinase_1 PF00349.21 KOG99871.1 - 6.4e-73 244.9 0.0 1.1e-72 244.2 0.0 1.4 1 0 0 1 1 1 1 Hexokinase FGGY_N PF00370.21 KOG99871.1 - 0.002 17.7 0.0 0.0036 16.9 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Apolipoprotein PF01442.18 KOG99871.1 - 0.051 13.4 0.0 0.083 12.8 0.0 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF1759 PF03564.15 KOG99871.1 - 0.2 11.6 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) Flocculin_t3 PF13928.6 KOG99873.1 - 5.9e-13 49.1 19.9 5.9e-13 49.1 19.9 6.4 4 2 0 4 4 4 1 Flocculin type 3 repeat Flocculin PF00624.18 KOG99873.1 - 3.8e-11 43.1 17.3 3.8e-11 43.1 17.3 7.4 4 4 2 6 6 6 1 Flocculin repeat Hyphal_reg_CWP PF11765.8 KOG99874.1 - 1.5e-27 96.4 13.9 1.5e-27 96.4 13.9 1.9 2 1 0 2 2 2 1 Hyphally regulated cell wall protein N-terminal FMN_bind_2 PF04299.12 KOG99875.1 - 6.5e-56 188.6 0.0 8e-56 188.4 0.0 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain Cys_Met_Meta_PP PF01053.20 KOG99876.1 - 1.5e-91 306.8 0.0 1.8e-91 306.6 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KOG99876.1 - 8.3e-07 28.5 0.0 1.2e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KOG99876.1 - 0.00065 18.8 0.0 0.00092 18.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KOG99876.1 - 0.00092 18.6 0.0 0.007 15.7 0.0 1.9 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 KOG99876.1 - 0.012 15.0 0.0 0.024 13.9 0.0 1.5 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Glyco_hydro_28 PF00295.17 KOG99877.1 - 2.8e-75 253.4 15.9 3.2e-75 253.2 15.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 KOG99877.1 - 0.0022 17.9 20.5 0.0027 17.6 18.6 1.9 1 1 0 2 2 2 1 Right handed beta helix region DUP PF00674.18 KOG99878.1 - 1.2e-47 160.3 12.3 2.2e-26 92.0 3.7 2.3 2 0 0 2 2 2 2 DUP family Aldo_ket_red PF00248.21 KOG99879.1 - 3.2e-44 151.3 0.0 3.6e-44 151.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family S-methyl_trans PF02574.16 KOG99880.1 - 5.3e-60 203.5 0.0 6e-60 203.3 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Kelch_1 PF01344.25 KOG99880.1 - 0.0031 17.1 0.1 0.012 15.1 0.0 2.0 2 0 0 2 2 2 1 Kelch motif AA_permease PF00324.21 KOG99881.1 - 2.4e-107 359.5 36.6 2.8e-107 359.3 36.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG99881.1 - 4.6e-37 127.9 38.6 6.3e-37 127.4 38.6 1.2 1 0 0 1 1 1 1 Amino acid permease FAD_binding_7 PF03441.14 KOG99882.1 - 5.4e-63 212.1 1.1 9.9e-62 208.0 1.1 2.4 1 1 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 KOG99882.1 - 1.6e-28 99.8 0.1 2.9e-28 98.9 0.1 1.4 1 0 0 1 1 1 1 DNA photolyase T6PP_N PF18572.1 KOG99882.1 - 0.14 12.0 0.3 0.37 10.6 0.3 1.7 1 0 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Acetyltransf_1 PF00583.25 KOG99883.1 - 1.2e-10 41.6 0.1 1.4e-10 41.4 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOG99883.1 - 2.3e-05 24.7 0.2 2.8e-05 24.5 0.2 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOG99883.1 - 0.0003 20.7 0.1 0.00039 20.4 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOG99883.1 - 0.00049 20.0 0.0 0.00071 19.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 KOG99883.1 - 0.002 18.8 0.2 0.0024 18.5 0.2 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 KOG99883.1 - 0.0028 17.4 0.1 0.04 13.6 0.1 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_CG PF14542.6 KOG99883.1 - 0.0057 16.8 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase MFS_1 PF07690.16 KOG99884.1 - 2e-11 43.4 47.2 1.5e-07 30.7 17.2 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 KOG99884.1 - 9.2e-06 24.4 27.6 0.00011 20.8 27.6 1.9 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 KOG99884.1 - 1.4e-05 24.2 34.8 1.6e-05 24.0 8.3 2.8 3 0 0 3 3 3 2 Sugar (and other) transporter DUF3796 PF12676.7 KOG99884.1 - 0.018 15.5 1.4 0.018 15.5 1.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3796) Aa_trans PF01490.18 KOG99885.1 - 1.3e-97 327.1 33.3 1.5e-97 327.0 33.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease PF00324.21 KOG99886.1 - 1.2e-143 479.3 52.1 1.3e-143 479.1 52.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOG99886.1 - 1.2e-24 86.9 56.0 1.8e-24 86.4 56.0 1.2 1 0 0 1 1 1 1 Amino acid permease NPR2 PF06218.11 KOG99887.1 - 2.8e-128 428.4 2.8 4.3e-128 427.8 2.8 1.3 1 1 0 1 1 1 1 Nitrogen permease regulator 2 Kinesin PF00225.23 KOG99888.1 - 1.9e-94 316.3 13.6 5.3e-62 209.7 9.6 4.0 4 1 0 4 4 4 2 Kinesin motor domain Microtub_bd PF16796.5 KOG99888.1 - 5e-21 75.2 0.0 5e-21 75.2 0.0 3.0 3 1 0 3 3 3 1 Microtubule binding DUF2730 PF10805.8 KOG99888.1 - 9.6 6.4 13.0 0.4 10.8 0.6 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) Peptidase_S8 PF00082.22 KOG99889.1 - 1.3e-33 116.6 5.3 1.3e-33 116.6 5.3 2.0 2 1 0 2 2 2 1 Subtilase family Inhibitor_I9 PF05922.16 KOG99889.1 - 6.7e-13 49.1 0.3 6.7e-13 49.1 0.3 2.5 3 0 0 3 3 3 1 Peptidase inhibitor I9 Zip PF02535.22 KOG99889.1 - 1.9 7.6 7.0 3.6 6.7 7.0 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter Mitochondr_Som1 PF11093.8 KOG99890.1 - 1.8e-11 43.8 0.2 2.4e-11 43.5 0.2 1.3 1 1 0 1 1 1 1 Mitochondrial export protein Som1 PGM_PMM_I PF02878.16 KOG99891.1 - 6.5e-16 58.3 0.1 3.4e-08 33.3 0.0 2.7 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 KOG99891.1 - 1.7e-09 37.7 0.0 5.2e-09 36.1 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 KOG99891.1 - 0.043 14.4 0.1 0.33 11.6 0.1 2.4 1 1 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II DUF4250 PF14056.6 KOG99892.1 - 0.15 12.0 3.6 6.5 6.8 0.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4250) CAF1C_H4-bd PF12265.8 KOG99893.1 - 4.9e-24 84.4 0.4 4.1e-23 81.4 0.1 2.5 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 KOG99893.1 - 2.2e-15 56.8 0.9 0.00026 21.7 0.1 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat CNH PF00780.22 KOG99893.1 - 0.0078 15.8 0.0 0.031 13.9 0.0 1.8 2 0 0 2 2 2 1 CNH domain ANAPC4_WD40 PF12894.7 KOG99893.1 - 0.017 15.4 0.0 0.1 12.9 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DNA_pol_phi PF04931.13 KOG99894.1 - 2.1e-215 717.3 24.4 2.8e-215 716.9 24.4 1.2 1 0 0 1 1 1 1 DNA polymerase phi COMPASS-Shg1 PF05205.12 KOG99894.1 - 0.0069 17.1 1.1 2.4 8.9 0.1 3.0 2 0 0 2 2 2 2 COMPASS (Complex proteins associated with Set1p) component shg1 Utp12 PF04003.12 KOG99894.1 - 0.015 15.6 0.2 0.084 13.2 0.2 2.3 1 0 0 1 1 1 0 Dip2/Utp12 Family GET2 PF08690.10 KOG99894.1 - 0.16 11.6 6.4 0.35 10.5 6.4 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 SDA1 PF05285.12 KOG99894.1 - 0.33 10.3 19.3 0.83 9.0 19.3 1.6 1 0 0 1 1 1 0 SDA1 DUF3347 PF11827.8 KOG99894.1 - 1.2 9.3 6.9 3.1 7.9 6.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Ribosomal_L11_N PF03946.14 KOG99895.1 - 2.5e-21 75.2 0.3 4.6e-21 74.4 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 KOG99895.1 - 4.2e-17 62.4 0.9 9.4e-17 61.3 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain NusA_N PF08529.11 KOG99895.1 - 0.097 13.0 0.9 0.15 12.4 0.9 1.3 1 1 0 1 1 1 0 NusA N-terminal domain Mak10 PF04112.13 KOG99896.1 - 2.2e-43 147.7 0.0 6.3e-43 146.2 0.0 1.8 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase DUF2489 PF10675.9 KOG99896.1 - 0.018 14.9 2.1 0.028 14.3 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) DUF5082 PF16888.5 KOG99896.1 - 0.095 13.0 2.1 2.6 8.3 1.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Occludin_ELL PF07303.13 KOG99896.1 - 0.85 10.4 5.3 18 6.1 0.1 3.0 2 0 0 2 2 2 0 Occludin homology domain Syntaxin_2 PF14523.6 KOG99896.1 - 5 7.6 7.6 21 5.6 0.4 3.6 4 0 0 4 4 4 0 Syntaxin-like protein AFG1_ATPase PF03969.16 KOG99897.1 - 2.5e-74 250.4 0.0 4.2e-68 229.9 0.0 3.8 2 1 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 KOG99897.1 - 4.7e-06 27.1 0.1 6.8e-05 23.3 0.1 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 KOG99897.1 - 0.00076 19.9 0.0 0.0016 18.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 KOG99897.1 - 0.0011 18.9 0.0 0.0019 18.1 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Bac_DnaA PF00308.18 KOG99897.1 - 0.0062 16.4 0.1 0.014 15.2 0.1 1.7 1 1 0 1 1 1 1 Bacterial dnaA protein RNA_helicase PF00910.22 KOG99897.1 - 0.028 14.8 0.0 0.095 13.1 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 KOG99897.1 - 0.033 14.5 0.1 0.085 13.1 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KOG99897.1 - 0.047 13.7 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 KOG99897.1 - 0.095 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP-synt_D PF01813.17 KOG99898.1 - 6.7e-69 231.7 4.0 8.6e-69 231.3 4.0 1.1 1 0 0 1 1 1 1 ATP synthase subunit D NARP1 PF12569.8 KOG99898.1 - 0.03 13.3 6.1 0.054 12.4 6.1 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 HtrL_YibB PF09612.10 KOG99898.1 - 0.033 13.7 0.6 0.052 13.1 0.6 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (HtrL_YibB) RICH PF05062.12 KOG99898.1 - 0.11 12.8 5.0 0.12 12.7 1.6 2.3 2 0 0 2 2 2 0 RICH domain Ribosomal_L2_C PF03947.18 KOG99899.1 - 1.2e-53 180.6 2.0 1.2e-53 180.6 2.0 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 KOG99899.1 - 1.1e-26 92.6 0.1 3.5e-26 91.0 0.0 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain SH3_15 PF18346.1 KOG99899.1 - 0.084 13.2 0.0 0.26 11.7 0.0 1.9 1 0 0 1 1 1 0 Mind bomb SH3 repeat domain SRP1_TIP1 PF00660.17 KOG99900.1 - 3.8e-27 94.3 0.0 5.1e-27 93.8 0.0 1.2 1 0 0 1 1 1 1 Seripauperin and TIP1 family Sedlin_N PF04628.13 KOG99901.1 - 1.4e-11 44.6 0.0 1.7e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region FAD_binding_2 PF00890.24 KOG99902.1 - 1.9e-74 251.2 0.0 2.2e-74 251.1 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOG99902.1 - 1.4e-11 44.6 0.1 4.8e-08 33.0 0.1 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOG99902.1 - 2.9e-08 33.8 0.0 1.2e-07 31.8 0.0 2.1 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 KOG99902.1 - 9.1e-08 31.7 0.0 1.8e-07 30.7 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 KOG99902.1 - 7e-07 28.6 0.1 0.0059 15.7 0.2 2.9 3 0 0 3 3 3 2 Lycopene cyclase protein Pyr_redox_2 PF07992.14 KOG99902.1 - 2.5e-06 26.9 3.5 4.7e-06 26.0 1.6 2.1 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOG99902.1 - 1.2e-05 24.7 1.5 0.00086 18.6 0.3 2.4 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 KOG99902.1 - 1.6e-05 24.4 0.1 0.069 12.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOG99902.1 - 0.00044 20.8 0.3 0.2 12.3 0.1 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOG99902.1 - 0.00049 20.1 0.0 0.34 10.9 0.0 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding HI0933_like PF03486.14 KOG99902.1 - 0.00058 18.7 4.9 0.039 12.7 0.1 3.3 4 0 0 4 4 4 2 HI0933-like protein Amino_oxidase PF01593.24 KOG99902.1 - 0.0009 18.6 0.0 0.027 13.8 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase MCRA PF06100.11 KOG99902.1 - 0.004 16.0 0.1 0.22 10.3 0.0 2.1 2 0 0 2 2 2 1 MCRA family SurA_N_3 PF13624.6 KOG99902.1 - 0.0065 16.3 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 SurA N-terminal domain FAD_oxidored PF12831.7 KOG99902.1 - 0.0095 15.3 0.8 0.072 12.4 0.8 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase SurA_N_2 PF13623.6 KOG99902.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 SurA N-terminal domain 3HCDH_N PF02737.18 KOG99902.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 KOG99902.1 - 0.23 10.5 1.4 0.94 8.5 0.1 2.4 3 0 0 3 3 3 0 Glucose inhibited division protein A Beta_elim_lyase PF01212.21 KOG99903.1 - 1.2e-79 267.7 0.0 1.4e-79 267.5 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 KOG99903.1 - 0.0029 16.8 0.0 0.004 16.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II YL1_C PF08265.11 KOG99904.1 - 2.8e-11 43.0 0.2 2.8e-11 43.0 0.2 2.0 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain GDA1_CD39 PF01150.17 KOG99906.1 - 2.6e-127 425.0 0.0 3.2e-127 424.7 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family NAD_kinase PF01513.21 KOG99907.1 - 2.3e-91 306.0 0.0 3.2e-91 305.6 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 KOG99907.1 - 0.014 15.0 0.0 0.073 12.7 0.0 2.0 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain Collectrin PF16959.5 KOG99907.1 - 0.055 13.2 2.2 0.88 9.3 0.0 2.9 3 0 0 3 3 3 0 Renal amino acid transporter eIF-1a PF01176.19 KOG99907.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 Glyco_hydro_16 PF00722.21 KOG99908.1 - 1e-43 148.8 5.1 1e-43 148.8 5.1 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 YcgR_2 PF12945.7 KOG99908.1 - 0.03 14.5 0.0 0.064 13.4 0.0 1.5 1 0 0 1 1 1 0 Flagellar protein YcgR Chitin_bind_1 PF00187.19 KOG99908.1 - 0.15 12.5 13.3 0.35 11.4 13.3 1.6 1 0 0 1 1 1 0 Chitin recognition protein Lin-8 PF03353.15 KOG99908.1 - 5.7 6.4 8.2 8.7 5.8 8.2 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SPX PF03105.19 KOG99908.1 - 5.8 6.7 17.7 7.9 6.3 17.7 1.1 1 0 0 1 1 1 0 SPX domain Cytochrom_C PF00034.21 KOG99909.1 - 3.7e-10 40.8 1.1 8.6e-10 39.6 1.1 1.6 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 KOG99909.1 - 5.2e-07 29.9 1.8 6e-06 26.5 1.8 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 KOG99909.1 - 0.016 14.9 0.6 0.05 13.3 0.1 1.9 2 0 0 2 2 2 0 Cytochrome c-550 domain HAD_2 PF13419.6 KOG99910.1 - 0.029 14.5 0.0 0.094 12.8 0.0 1.7 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase UBA PF00627.31 KOG99911.1 - 1.1e-30 105.1 2.8 3.9e-16 58.6 0.2 2.4 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.23 KOG99911.1 - 2e-18 65.9 0.4 3.9e-18 65.0 0.3 1.5 2 0 0 2 2 2 1 Ubiquitin family XPC-binding PF09280.11 KOG99911.1 - 2.4e-11 43.2 0.3 4.2e-11 42.4 0.3 1.4 1 0 0 1 1 1 1 XPC-binding domain Rad60-SLD PF11976.8 KOG99911.1 - 1.7e-06 27.8 0.0 5.2e-06 26.2 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 KOG99911.1 - 4e-06 26.9 0.0 8.5e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 KOG99911.1 - 2.8e-05 24.4 0.2 4.5e-05 23.7 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 KOG99911.1 - 0.0011 19.5 0.0 0.0025 18.4 0.0 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain CUE PF02845.16 KOG99911.1 - 0.0046 16.6 1.1 2.6 7.8 0.0 4.3 3 2 1 4 4 4 1 CUE domain DUF444 PF04285.12 KOG99911.1 - 0.041 13.0 1.7 0.076 12.1 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF444) DUF1421 PF07223.11 KOG99911.1 - 0.05 13.4 0.0 0.55 10.1 0.0 2.4 2 0 0 2 2 2 0 UBA-like domain (DUF1421) RepB PF07506.11 KOG99911.1 - 0.097 12.8 0.2 0.42 10.7 0.0 2.0 1 1 1 2 2 2 0 RepB plasmid partitioning protein UBA_2 PF08587.11 KOG99911.1 - 0.12 12.5 0.1 0.76 9.9 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) Ashwin PF15323.6 KOG99911.1 - 0.29 11.1 4.0 0.5 10.4 4.0 1.4 1 0 0 1 1 1 0 Developmental protein DUF3306 PF11748.8 KOG99911.1 - 7 7.5 13.3 0.42 11.5 3.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) HNF-1_N PF04814.13 KOG99911.1 - 9.9 6.7 7.6 4.1 8.0 4.5 1.8 1 1 1 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Anp1 PF03452.14 KOG99912.1 - 8.7e-113 376.1 0.1 2.2e-112 374.8 0.0 1.7 2 0 0 2 2 2 1 Anp1 GldH_lipo PF14109.6 KOG99912.1 - 0.0031 18.3 0.0 0.0086 16.8 0.0 1.7 1 0 0 1 1 1 1 GldH lipoprotein SUIM_assoc PF16619.5 KOG99912.1 - 0.0036 17.3 2.3 0.0036 17.3 2.3 2.0 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 KOG99912.1 - 0.39 10.3 11.9 1 8.9 11.0 2.0 2 0 0 2 2 2 0 Spt20 family eIF-5a PF01287.20 KOG99913.1 - 1.9e-30 104.8 0.7 2.6e-30 104.3 0.7 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 KOG99913.1 - 0.0019 18.2 0.0 0.003 17.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain MCM PF00493.23 KOG99914.1 - 1.3e-97 325.3 0.4 2.2e-97 324.5 0.4 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KOG99914.1 - 2.3e-32 111.5 0.0 4.8e-32 110.5 0.0 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KOG99914.1 - 1.8e-24 86.0 1.6 3.8e-24 84.9 1.6 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 KOG99914.1 - 1.4e-07 31.1 0.0 1.8e-06 27.5 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 KOG99914.1 - 1.5e-07 31.9 0.8 1.5e-06 28.7 0.1 2.9 2 1 0 2 2 2 1 MCM N-terminal domain AAA_3 PF07726.11 KOG99914.1 - 0.002 18.0 0.3 0.0088 15.9 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ORC6 PF05460.13 KOG99914.1 - 0.011 15.0 3.5 0.023 14.0 3.5 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Sigma54_activat PF00158.26 KOG99914.1 - 0.018 14.7 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.14 KOG99914.1 - 0.13 12.3 0.0 0.45 10.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) E1-E2_ATPase PF00122.20 KOG99915.1 - 2.5e-18 66.3 0.3 5.6e-18 65.1 0.1 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KOG99915.1 - 1.9e-17 64.3 0.0 1.1e-10 42.2 0.0 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOG99915.1 - 1.2e-05 25.3 0.0 2.4e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KOG99915.1 - 0.0025 17.6 0.1 0.029 14.1 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 KOG99915.1 - 0.096 12.2 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase BES1_N PF05687.13 KOG99915.1 - 0.17 12.2 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal HSP70 PF00012.20 KOG99916.1 - 4.2e-260 864.1 11.6 4.8e-260 863.9 11.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOG99916.1 - 2e-16 59.8 2.5 2.6e-14 52.8 0.8 2.5 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 KOG99916.1 - 0.00023 21.0 0.0 0.00054 19.7 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 KOG99916.1 - 0.0074 16.7 7.6 1.3 9.5 0.8 4.1 3 2 0 3 3 3 1 Cell division protein FtsA DUF4876 PF16215.5 KOG99916.1 - 0.023 14.7 1.6 0.074 13.0 1.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4876) Ploopntkinase3 PF18751.1 KOG99916.1 - 0.033 14.1 0.2 0.64 9.9 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 DUF16 PF01519.16 KOG99916.1 - 0.58 10.7 4.3 1.8 9.1 4.3 1.8 1 0 0 1 1 1 0 Protein of unknown function DUF16 Prominin PF05478.11 KOG99916.1 - 5.2 4.9 7.1 7.2 4.4 5.9 1.6 2 0 0 2 2 2 0 Prominin Phos_pyr_kin PF08543.12 KOG99917.1 - 3.3e-11 43.0 0.0 4.2e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 KOG99917.1 - 9.1e-07 28.5 0.0 1.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase ATP-synt_C PF00137.21 KOG99918.1 - 4.6e-34 116.6 30.8 6.4e-22 77.7 12.8 2.2 2 0 0 2 2 2 2 ATP synthase subunit C DUF2970 PF11174.8 KOG99918.1 - 1.8 8.5 9.4 0.87 9.5 1.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Ribosomal_L7Ae PF01248.26 KOG99919.1 - 1e-27 95.7 0.1 1.2e-27 95.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 KOG99919.1 - 0.0019 18.1 0.0 0.0025 17.6 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 KOG99919.1 - 0.014 15.4 0.0 0.015 15.4 0.0 1.1 1 0 0 1 1 1 0 RNase P subunit Pop3 Pico_P2B PF01552.17 KOG99919.1 - 0.071 13.3 0.0 0.14 12.3 0.0 1.4 1 1 0 1 1 1 0 Picornavirus 2B protein Rieske PF00355.26 KOG99921.1 - 7.9e-11 41.8 0.0 1.3e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 KOG99921.1 - 2.9e-09 37.2 0.4 7.5e-09 35.9 0.4 1.7 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region DUF2235 PF09994.9 KOG99922.1 - 2.2e-82 276.7 0.0 3.3e-82 276.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Sec7 PF01369.20 KOG99923.1 - 7.9e-68 227.7 1.1 2.1e-67 226.4 0.5 2.2 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 KOG99923.1 - 3.4e-13 49.8 3.8 3.4e-13 49.8 3.8 3.6 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 KOG99923.1 - 0.0018 17.9 1.2 0.0018 17.9 1.2 4.1 4 0 0 4 4 4 1 Dimerisation and cyclophilin-binding domain of Mon2 DUF2683 PF10884.8 KOG99923.1 - 0.02 15.1 1.7 0.095 13.0 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2683) Fucose_iso_N2 PF07882.12 KOG99923.1 - 0.046 13.3 0.0 0.24 10.9 0.0 2.2 2 0 0 2 2 2 0 L-fucose isomerase, second N-terminal domain DnaB_2 PF07261.11 KOG99923.1 - 0.061 13.1 0.2 0.69 9.7 0.0 2.8 2 0 0 2 2 2 0 Replication initiation and membrane attachment Alpha-amylase_C PF02806.18 KOG99924.1 - 4.7e-28 97.5 0.7 2.5e-27 95.2 0.1 2.4 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 KOG99924.1 - 3.6e-17 62.5 0.0 1e-16 61.0 0.0 1.9 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 KOG99924.1 - 1.7e-13 50.9 0.2 1.2e-12 48.1 0.1 2.3 1 1 1 2 2 2 1 Alpha amylase, catalytic domain Tenui_N PF05733.11 KOG99924.1 - 0.025 14.1 0.0 2.2 7.8 0.0 2.1 2 0 0 2 2 2 0 Tenuivirus/Phlebovirus nucleocapsid protein Glyco_hydro_66 PF13199.6 KOG99924.1 - 0.033 12.9 0.0 0.052 12.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 AMPK1_CBM PF16561.5 KOG99924.1 - 0.053 13.7 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase UQ_con PF00179.26 KOG99925.1 - 2e-39 134.5 0.1 2.3e-39 134.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOG99925.1 - 0.056 13.7 0.5 0.13 12.5 0.5 1.8 1 1 0 1 1 1 0 RWD domain BUD22 PF09073.10 KOG99925.1 - 0.14 11.4 6.9 0.18 11.1 6.9 1.0 1 0 0 1 1 1 0 BUD22 Arm PF00514.23 KOG99926.1 - 9.2e-73 238.3 25.6 1.9e-12 46.7 0.0 10.6 11 0 0 11 11 11 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOG99926.1 - 1.2e-20 73.5 16.0 4.6e-05 23.8 0.1 8.4 6 2 2 8 8 8 5 HEAT-like repeat HEAT_2 PF13646.6 KOG99926.1 - 6e-17 61.8 8.5 0.00043 20.6 0.0 7.0 3 2 3 7 7 7 4 HEAT repeats Adaptin_N PF01602.20 KOG99926.1 - 6.1e-12 44.9 12.6 3.3e-08 32.6 3.5 3.1 1 1 1 2 2 2 2 Adaptin N terminal region HEAT PF02985.22 KOG99926.1 - 3.1e-11 42.5 28.0 0.063 13.6 0.2 10.3 12 0 0 12 12 11 3 HEAT repeat KAP PF05804.12 KOG99926.1 - 1.8e-10 39.7 0.6 1.3e-09 36.9 0.6 2.0 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) Arm_2 PF04826.13 KOG99926.1 - 4.2e-09 36.3 8.2 1.5e-06 27.9 2.1 3.0 2 1 0 3 3 3 2 Armadillo-like DUF3361 PF11841.8 KOG99926.1 - 2e-06 27.8 5.7 0.0029 17.6 0.2 4.3 1 1 2 5 5 5 1 Domain of unknown function (DUF3361) V-ATPase_H_C PF11698.8 KOG99926.1 - 3e-06 27.3 1.8 0.14 12.3 0.1 4.8 3 2 2 5 5 5 2 V-ATPase subunit H Cnd1 PF12717.7 KOG99926.1 - 7.4e-06 26.1 10.4 0.36 10.9 0.2 5.2 1 1 4 5 5 5 3 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 KOG99926.1 - 4.6e-05 22.9 3.4 0.0033 16.8 0.5 3.4 1 1 3 4 4 4 2 V-ATPase subunit H Vac14_Fab1_bd PF12755.7 KOG99926.1 - 5.4e-05 23.7 0.3 0.29 11.7 0.0 3.9 3 2 1 4 4 4 2 Vacuolar 14 Fab1-binding region Tti2 PF10521.9 KOG99926.1 - 0.0011 18.6 0.0 0.17 11.4 0.0 3.2 3 0 0 3 3 3 1 Tti2 family Proteasom_PSMB PF10508.9 KOG99926.1 - 0.0032 16.0 1.8 4.1 5.8 0.0 3.3 1 1 1 3 3 3 1 Proteasome non-ATPase 26S subunit RIF5_SNase_1 PF18187.1 KOG99926.1 - 0.021 14.6 0.0 0.047 13.4 0.0 1.6 1 0 0 1 1 1 0 TbRIF5 SNase domain 1 DUF5578 PF17741.1 KOG99926.1 - 0.069 12.6 7.6 2.7 7.3 0.3 4.0 2 2 2 4 4 4 0 Family of unknown function (DUF5578) UNC45-central PF11701.8 KOG99926.1 - 0.09 12.7 9.3 16 5.5 0.0 4.7 3 1 0 5 5 5 0 Myosin-binding striated muscle assembly central RasGEF_N_2 PF14663.6 KOG99926.1 - 0.094 13.1 4.3 58 4.1 0.1 4.8 3 1 1 5 5 5 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain YjeF_N PF03853.15 KOG99927.1 - 3.2e-37 128.0 0.0 5.4e-37 127.3 0.0 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 KOG99927.1 - 3.4e-17 63.2 7.5 3.4e-17 63.2 7.5 2.4 2 0 0 2 2 2 1 FDF domain Ripply PF14998.6 KOG99927.1 - 0.38 11.4 5.7 0.41 11.3 0.0 2.8 3 0 0 3 3 3 0 Transcription Regulator RITA PF17066.5 KOG99927.1 - 8.6 5.9 9.0 0.27 10.8 2.0 1.9 2 0 0 2 2 2 0 RBPJ-interacting and tubulin associated protein Phosphodiest PF01663.22 KOG99928.1 - 2.1e-74 251.3 0.7 2.5e-74 251.0 0.7 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KOG99928.1 - 0.077 12.4 0.0 0.26 10.7 0.0 1.8 1 1 1 2 2 2 0 Sulfatase Dynactin_p62 PF05502.13 KOG99929.1 - 0.042 12.6 0.4 0.057 12.2 0.4 1.2 1 0 0 1 1 1 0 Dynactin p62 family PMP1_2 PF08114.11 KOG99930.1 - 3.8e-27 93.7 3.6 4.1e-27 93.6 3.6 1.0 1 0 0 1 1 1 1 ATPase proteolipid family CD34_antigen PF06365.12 KOG99930.1 - 0.037 13.6 0.3 0.039 13.5 0.3 1.0 1 0 0 1 1 1 0 CD34/Podocalyxin family Vpu PF00558.19 KOG99930.1 - 0.098 12.4 0.9 0.095 12.5 0.9 1.0 1 0 0 1 1 1 0 Vpu protein PCI PF01399.27 KOG99931.1 - 0.093 13.2 0.0 0.4 11.2 0.0 1.8 1 1 0 1 1 1 0 PCI domain RVT_connect PF06815.13 KOG99931.1 - 0.1 12.9 0.2 0.74 10.1 0.0 2.1 2 0 0 2 2 2 0 Reverse transcriptase connection domain zf-Nse PF11789.8 KOG99932.1 - 6.3e-23 80.4 0.7 2.2e-22 78.7 0.5 2.1 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 KOG99932.1 - 0.00021 21.1 2.2 0.00031 20.5 0.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOG99932.1 - 0.00082 19.3 1.2 0.00082 19.3 1.2 2.0 2 0 0 2 2 2 1 RING-type zinc-finger Ku_PK_bind PF08785.11 KOG99932.1 - 0.0049 17.0 0.0 0.0092 16.1 0.0 1.4 1 0 0 1 1 1 1 Ku C terminal domain like zf-ANAPC11 PF12861.7 KOG99932.1 - 0.0056 16.7 0.3 0.014 15.4 0.3 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 KOG99932.1 - 0.01 15.7 0.5 0.032 14.1 0.5 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.20 KOG99932.1 - 0.013 15.3 1.6 0.029 14.1 0.6 2.2 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-rbx1 PF12678.7 KOG99932.1 - 0.026 14.8 1.1 0.061 13.6 0.3 2.1 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 KOG99932.1 - 0.033 14.5 2.5 0.053 13.9 1.0 2.2 2 0 0 2 2 2 0 Ring finger domain Fzo_mitofusin PF04799.13 KOG99932.1 - 0.14 11.7 0.6 0.47 10.0 0.1 1.8 2 0 0 2 2 2 0 fzo-like conserved region TPP_enzyme_N PF02776.18 KOG99933.1 - 3.2e-43 147.3 0.0 1.7e-41 141.7 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 KOG99933.1 - 2.2e-27 95.5 0.0 4.2e-27 94.6 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 KOG99933.1 - 8.8e-21 74.3 0.1 8.7e-20 71.1 0.0 2.5 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Maff2 PF12750.7 KOG99933.1 - 0.41 10.5 2.2 1.1 9.2 0.1 2.7 3 0 0 3 3 3 0 Maff2 family zf-Tim10_DDP PF02953.15 KOG99934.1 - 3.5e-20 71.4 7.8 5.4e-20 70.8 7.8 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Phasin_2 PF09361.10 KOG99934.1 - 0.026 14.8 0.1 0.3 11.4 0.0 2.0 1 1 1 2 2 2 0 Phasin protein Tam41_Mmp37 PF09139.11 KOG99934.1 - 0.044 13.2 0.5 0.048 13.1 0.5 1.0 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial OMPdecase PF00215.24 KOG99935.1 - 2.1e-75 253.2 0.0 2.4e-75 253.0 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family DUF4668 PF15701.5 KOG99936.1 - 2.2e-34 118.6 6.9 2.6e-34 118.4 6.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4668) bZIP_2 PF07716.15 KOG99937.1 - 4.1e-12 46.0 12.5 7.3e-12 45.2 12.5 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 KOG99937.1 - 1.1e-11 44.7 9.5 2.4e-11 43.5 9.5 1.5 1 0 0 1 1 1 1 bZIP transcription factor DUF1843 PF08898.10 KOG99937.1 - 0.021 15.3 1.0 0.045 14.3 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1843) FA_desaturase PF00487.24 KOG99937.1 - 0.14 12.0 1.7 0.19 11.5 1.7 1.1 1 0 0 1 1 1 0 Fatty acid desaturase ZapB PF06005.12 KOG99937.1 - 0.25 11.8 7.5 0.073 13.5 4.3 1.8 2 0 0 2 2 2 0 Cell division protein ZapB DivIC PF04977.15 KOG99937.1 - 0.83 9.5 3.8 1.7 8.5 3.8 1.5 1 0 0 1 1 1 0 Septum formation initiator bZIP_Maf PF03131.17 KOG99937.1 - 0.97 10.0 13.3 0.1 13.1 8.2 1.9 2 0 0 2 2 2 0 bZIP Maf transcription factor Gti1_Pac2 PF09729.9 KOG99939.1 - 8.6e-56 188.9 0.0 8.6e-56 188.9 0.0 4.4 4 1 0 4 4 4 2 Gti1/Pac2 family Mito_carr PF00153.27 KOG99940.1 - 1.7e-69 229.8 2.8 3.6e-23 81.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2284 PF10050.9 KOG99941.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2284) FlaC_arch PF05377.11 KOG99941.1 - 1.3 9.4 7.3 4.5 7.7 0.5 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) UAA PF08449.11 KOG99942.1 - 1.3e-101 339.8 16.6 1.4e-101 339.7 16.6 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 KOG99942.1 - 7.4e-05 22.2 4.3 7.4e-05 22.2 4.3 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family Ycf66_N PF07444.11 KOG99942.1 - 0.013 15.6 0.1 0.074 13.2 0.1 2.3 1 0 0 1 1 1 0 Ycf66 protein N-terminus DUF996 PF06195.13 KOG99942.1 - 6.4 7.1 10.9 3.1 8.1 1.2 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF996) Prefoldin_2 PF01920.20 KOG99943.1 - 2.4e-21 75.7 6.2 2.8e-21 75.5 6.2 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF2383 PF09537.10 KOG99943.1 - 0.0078 16.6 0.4 0.017 15.5 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2383) Prefoldin PF02996.17 KOG99943.1 - 0.0088 16.0 3.2 1.3 9.0 0.3 2.2 1 1 1 2 2 2 2 Prefoldin subunit Occludin_ELL PF07303.13 KOG99943.1 - 0.13 13.1 6.1 2.2 9.1 0.7 2.1 1 1 1 2 2 2 0 Occludin homology domain BLOC1_2 PF10046.9 KOG99943.1 - 0.15 12.4 4.6 0.17 12.2 0.7 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG6_N PF17675.1 KOG99943.1 - 0.27 11.8 5.4 3.7 8.1 5.4 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region DDOST_48kD PF03345.14 KOG99944.1 - 9.7e-123 410.1 3.2 1.1e-122 409.8 3.2 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Nop16 PF09420.10 KOG99946.1 - 3.9e-70 236.2 11.7 5.3e-70 235.7 11.7 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 PCNP PF15473.6 KOG99946.1 - 0.0057 17.4 1.2 0.013 16.3 1.2 1.6 1 0 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family GOLD_2 PF13897.6 KOG99946.1 - 0.52 10.8 3.0 0.87 10.1 3.0 1.4 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking PMI_typeI PF01238.21 KOG99947.1 - 8e-141 469.6 0.0 9.1e-141 469.4 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 KOG99947.1 - 1.4e-08 34.7 0.0 2.7e-05 24.1 0.0 2.9 3 0 0 3 3 3 2 AraC-like ligand binding domain Cupin_2 PF07883.11 KOG99947.1 - 0.0014 18.3 0.0 2.1 8.1 0.0 2.4 2 0 0 2 2 2 2 Cupin domain AraC_binding_2 PF14525.6 KOG99947.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 AraC-binding-like domain HIM1 PF08732.10 KOG99948.1 - 1.5e-10 40.9 0.0 1.2e-09 37.9 0.0 2.0 1 1 1 2 2 2 1 HIM1 NAD_binding_10 PF13460.6 KOG99948.1 - 3.2e-06 27.2 0.0 4.3e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOG99948.1 - 4.3e-06 26.4 0.0 6.3e-05 22.6 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 KOG99948.1 - 0.014 15.9 0.0 0.46 10.9 0.0 2.1 1 1 1 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 KOG99948.1 - 0.017 14.7 0.0 0.039 13.5 0.0 1.5 1 1 0 1 1 1 0 NmrA-like family GDA1_CD39 PF01150.17 KOG99949.1 - 2.3e-166 553.7 0.0 4.6e-166 552.7 0.0 1.4 2 0 0 2 2 2 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 KOG99949.1 - 0.037 13.4 0.0 0.086 12.3 0.0 1.5 1 0 0 1 1 1 0 Ppx/GppA phosphatase family CAP_GLY PF01302.25 KOG99950.1 - 7.6e-14 51.5 0.3 1.3e-13 50.8 0.3 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 KOG99950.1 - 9.6e-10 38.6 34.8 0.0075 16.7 2.1 5.9 3 1 0 5 5 5 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOG99950.1 - 1.1e-07 31.3 26.8 0.37 11.0 0.1 8.8 8 0 0 8 8 8 5 Leucine Rich repeat LRR_8 PF13855.6 KOG99950.1 - 2.5e-07 30.3 31.2 1.1e-05 25.0 4.8 6.2 1 1 7 8 8 8 6 Leucine rich repeat LRR_1 PF00560.33 KOG99950.1 - 0.25 12.0 26.0 5.4 8.0 0.0 8.1 4 3 1 5 5 5 0 Leucine Rich Repeat PUA PF01472.20 KOG99951.1 - 2.7e-14 52.9 0.0 3.1e-14 52.7 0.0 1.0 1 0 0 1 1 1 1 PUA domain Sec3_C PF09763.9 KOG99953.1 - 3.1e-173 577.9 31.7 3.1e-173 577.9 31.7 2.2 2 0 0 2 2 2 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 KOG99953.1 - 2.6e-25 88.4 0.2 1.1e-24 86.4 0.2 2.2 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH FAM222A PF15258.6 KOG99953.1 - 3 6.9 11.4 6.6 5.7 11.4 1.5 1 0 0 1 1 1 0 Protein family of FAM222A TFIIA PF03153.13 KOG99953.1 - 4.1 7.3 32.6 1.1 9.2 29.0 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit NTF2 PF02136.20 KOG99954.1 - 1.1e-36 126.0 0.6 1.3e-36 125.8 0.6 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4518 PF15008.6 KOG99954.1 - 0.00013 21.2 0.7 0.00072 18.8 0.7 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4518) Glyco_transf_52 PF07922.11 KOG99954.1 - 0.035 13.4 0.4 0.28 10.4 0.0 1.9 1 1 1 2 2 2 0 Glycosyltransferase family 52 DUF4440 PF14534.6 KOG99954.1 - 0.16 12.4 0.0 0.19 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) RraA-like PF03737.15 KOG99955.1 - 1.4e-32 113.0 0.0 1.8e-32 112.6 0.0 1.1 1 0 0 1 1 1 1 Aldolase/RraA SRP1_TIP1 PF00660.17 KOG99956.1 - 1.4e-37 127.7 0.4 1.4e-37 127.7 0.4 2.0 2 0 0 2 2 2 1 Seripauperin and TIP1 family PIR PF00399.19 KOG99956.1 - 4e-07 29.4 7.2 4e-07 29.4 7.2 2.7 2 0 0 2 2 2 1 Yeast PIR protein repeat PARM PF17061.5 KOG99956.1 - 0.0066 16.6 32.2 0.0077 16.4 32.2 1.2 1 0 0 1 1 1 1 PARM Spc42p PF11544.8 KOG99956.1 - 0.013 15.5 0.0 0.044 13.8 0.0 1.8 1 0 0 1 1 1 0 Spindle pole body component Spc42p TFIIA PF03153.13 KOG99956.1 - 0.51 10.3 10.2 0.58 10.1 10.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 KOG99956.1 - 0.64 8.7 10.7 0.89 8.2 10.7 1.3 1 0 0 1 1 1 0 Presenilin Hamartin PF04388.12 KOG99956.1 - 0.92 8.1 13.9 0.96 8.0 13.9 1.1 1 0 0 1 1 1 0 Hamartin protein DUF572 PF04502.13 KOG99956.1 - 1.7 8.2 9.9 1.9 8.0 9.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DDHD PF02862.17 KOG99956.1 - 1.8 8.7 12.6 3 7.9 12.6 1.4 1 0 0 1 1 1 0 DDHD domain SOG2 PF10428.9 KOG99956.1 - 1.8 7.7 26.7 2.2 7.4 26.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein SOBP PF15279.6 KOG99956.1 - 2.8 8.5 16.8 3.9 8.0 16.8 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein CytochromB561_N PF09786.9 KOG99956.1 - 3.7 6.4 20.3 3.8 6.4 20.3 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal Utp14 PF04615.13 KOG99956.1 - 4.3 5.8 18.2 5.5 5.4 18.2 1.1 1 0 0 1 1 1 0 Utp14 protein Hid1 PF12722.7 KOG99956.1 - 4.3 5.3 13.0 5.1 5.1 13.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Proteasome PF00227.26 KOG99957.1 - 8.1e-45 152.6 0.0 9.3e-45 152.5 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit HA2 PF04408.23 KOG99958.1 - 1.1e-22 80.4 1.8 2.7e-22 79.1 0.0 2.6 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KOG99958.1 - 1.7e-18 66.7 0.0 4.2e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KOG99958.1 - 5.5e-14 52.5 0.0 2.8e-13 50.2 0.0 2.3 1 1 1 2 2 2 1 Helicase conserved C-terminal domain S1 PF00575.23 KOG99958.1 - 3.2e-12 46.6 0.3 1.4e-11 44.6 0.3 2.1 1 0 0 1 1 1 1 S1 RNA binding domain PWI PF01480.17 KOG99958.1 - 4.2e-05 23.8 1.1 0.027 14.8 0.1 2.7 2 0 0 2 2 2 2 PWI domain AAA_22 PF13401.6 KOG99958.1 - 7.1e-05 23.1 0.0 0.00023 21.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 KOG99958.1 - 0.00012 21.9 0.6 0.00056 19.7 0.6 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 KOG99958.1 - 0.0021 17.2 0.0 0.0094 15.0 0.0 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 KOG99958.1 - 0.0032 17.2 0.1 0.0062 16.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 KOG99958.1 - 0.0063 17.0 5.4 0.39 11.2 0.0 4.3 3 1 1 4 4 4 1 ABC transporter AAA_14 PF13173.6 KOG99958.1 - 0.013 15.5 0.1 0.2 11.7 0.1 2.8 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOG99958.1 - 0.02 14.4 0.0 0.055 13.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 KOG99958.1 - 0.031 14.6 0.1 0.063 13.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 KOG99958.1 - 0.04 13.5 0.1 0.091 12.4 0.1 1.6 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA PF00004.29 KOG99958.1 - 0.13 12.6 2.1 0.6 10.5 0.1 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 KOG99958.1 - 0.84 10.1 0.0 0.84 10.1 0.0 3.5 3 0 0 3 3 3 0 AAA domain Amino_oxidase PF01593.24 KOG99959.1 - 5.3e-15 55.7 0.0 6.6e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOG99959.1 - 7.2e-13 48.6 0.0 1.5e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KOG99959.1 - 4e-05 24.1 0.8 0.009 16.6 0.0 3.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOG99959.1 - 5.9e-05 22.8 0.0 0.00013 21.6 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 KOG99959.1 - 0.00014 21.2 0.0 0.00029 20.2 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 KOG99959.1 - 0.0017 17.6 0.0 0.019 14.2 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOG99959.1 - 0.0027 17.7 0.0 0.0095 15.9 0.0 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding Globin PF00042.22 KOG99959.1 - 0.091 13.3 0.1 0.22 12.1 0.1 1.6 1 0 0 1 1 1 0 Globin Mqo PF06039.15 KOG99959.1 - 0.13 10.8 0.0 0.25 9.8 0.0 1.4 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) AMP-binding PF00501.28 KOG99960.1 - 3.7e-70 236.6 0.0 4.7e-70 236.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme SRP1_TIP1 PF00660.17 KOG99961.1 - 2.8e-26 91.5 0.0 3.8e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 Seripauperin and TIP1 family EB1 PF03271.17 KOG99962.1 - 8.4e-16 57.9 0.1 1.7e-15 56.9 0.1 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 KOG99962.1 - 2.6e-05 24.3 0.2 5.2e-05 23.4 0.2 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain ATG16 PF08614.11 KOG99962.1 - 0.012 15.8 0.2 0.022 15.0 0.2 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) zf-C4H2 PF10146.9 KOG99962.1 - 0.025 14.9 0.7 0.046 14.0 0.2 1.5 2 0 0 2 2 2 0 Zinc finger-containing protein DivIC PF04977.15 KOG99962.1 - 0.039 13.7 0.1 0.07 12.9 0.1 1.4 1 0 0 1 1 1 0 Septum formation initiator CENP-F_leu_zip PF10473.9 KOG99962.1 - 0.043 13.8 0.3 0.068 13.2 0.3 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FliJ PF02050.16 KOG99962.1 - 0.066 13.4 0.2 0.12 12.7 0.2 1.3 1 0 0 1 1 1 0 Flagellar FliJ protein CH_2 PF06294.11 KOG99962.1 - 0.075 13.2 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 CH-like domain in sperm protein Laminin_II PF06009.12 KOG99962.1 - 0.089 12.8 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 Laminin Domain II HR1 PF02185.16 KOG99962.1 - 0.1 12.7 0.1 0.21 11.8 0.1 1.4 1 0 0 1 1 1 0 Hr1 repeat Peptidase_M41 PF01434.18 KOG99963.1 - 9.7e-68 227.8 0.0 1.5e-67 227.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KOG99963.1 - 1.2e-42 145.5 0.0 2.3e-42 144.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG99963.1 - 3.1e-12 46.1 0.0 9.3e-12 44.6 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 KOG99963.1 - 1.6e-06 28.4 0.7 5.3e-06 26.7 0.7 1.9 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 KOG99963.1 - 0.00012 22.1 0.1 0.0005 20.1 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KOG99963.1 - 0.0043 16.8 0.0 0.0095 15.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOG99963.1 - 0.0051 17.1 0.3 0.53 10.6 0.1 2.9 2 1 0 3 3 3 1 AAA domain TIP49 PF06068.13 KOG99963.1 - 0.0067 15.7 0.0 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 KOG99963.1 - 0.012 16.0 0.1 0.057 13.8 0.1 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_2 PF07724.14 KOG99963.1 - 0.013 15.6 0.0 0.069 13.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 KOG99963.1 - 0.027 14.2 0.0 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.6 KOG99963.1 - 0.039 14.4 0.2 0.12 12.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain APG6_N PF17675.1 KOG99964.1 - 3.2e-05 24.4 12.8 4e-05 24.1 12.8 1.1 1 0 0 1 1 1 1 Apg6 coiled-coil region Filament PF00038.21 KOG99964.1 - 6e-05 22.8 11.7 7e-05 22.5 11.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein Phasin_2 PF09361.10 KOG99964.1 - 0.00063 20.0 1.8 0.00063 20.0 1.8 2.3 1 1 1 2 2 2 1 Phasin protein GAS PF13851.6 KOG99964.1 - 0.011 15.2 7.8 0.016 14.6 7.8 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding KASH_CCD PF14662.6 KOG99964.1 - 0.011 15.6 9.8 0.013 15.3 9.8 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Citrate_synt PF00285.21 KOG99964.1 - 0.013 14.6 2.8 0.014 14.5 2.8 1.0 1 0 0 1 1 1 0 Citrate synthase, C-terminal domain DUF4407 PF14362.6 KOG99964.1 - 0.019 14.3 10.8 0.024 14.0 10.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF713 PF05218.14 KOG99964.1 - 0.031 14.0 1.1 0.042 13.6 0.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF713) TMF_TATA_bd PF12325.8 KOG99964.1 - 0.032 14.4 10.7 0.11 12.8 10.0 2.2 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding YabA PF06156.13 KOG99964.1 - 0.04 14.5 5.9 0.078 13.6 5.8 1.7 1 1 0 1 1 1 0 Initiation control protein YabA Lebercilin PF15619.6 KOG99964.1 - 0.046 13.4 17.0 0.055 13.1 17.0 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Baculo_PEP_C PF04513.12 KOG99964.1 - 0.047 13.7 2.5 0.076 13.0 2.5 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-C4H2 PF10146.9 KOG99964.1 - 0.054 13.8 2.9 0.062 13.6 2.9 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein Spc7 PF08317.11 KOG99964.1 - 0.06 12.2 9.4 0.042 12.7 7.8 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein NTPase_1 PF03266.15 KOG99964.1 - 0.07 13.0 0.1 0.35 10.7 0.1 2.0 1 1 0 1 1 1 0 NTPase DUF2884 PF11101.8 KOG99964.1 - 0.073 12.6 6.6 0.048 13.2 3.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2884) FapA PF03961.13 KOG99964.1 - 0.083 11.5 1.0 0.086 11.4 1.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMPIT PF07851.13 KOG99964.1 - 0.13 11.5 4.1 0.15 11.3 4.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein ATG16 PF08614.11 KOG99964.1 - 0.17 12.1 19.0 0.41 10.9 10.7 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 KOG99964.1 - 0.17 11.9 3.1 0.24 11.4 3.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.19 KOG99964.1 - 0.18 9.7 5.2 0.2 9.6 5.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Phage_GPO PF05929.11 KOG99964.1 - 0.18 11.4 6.3 0.21 11.2 6.3 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase IFT57 PF10498.9 KOG99964.1 - 0.24 10.3 7.7 0.29 10.1 7.7 1.3 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 HAUS-augmin3 PF14932.6 KOG99964.1 - 0.3 10.6 12.2 0.39 10.2 12.1 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 Prominin PF05478.11 KOG99964.1 - 0.31 8.9 2.1 0.31 8.9 2.1 1.0 1 0 0 1 1 1 0 Prominin Exonuc_VII_L PF02601.15 KOG99964.1 - 0.32 10.5 12.6 0.38 10.3 12.6 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 KOG99964.1 - 0.45 9.5 10.4 0.54 9.3 10.4 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Seryl_tRNA_N PF02403.22 KOG99964.1 - 0.46 10.7 5.9 1.2 9.3 5.7 1.7 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain CENP-H PF05837.12 KOG99964.1 - 0.48 10.9 13.1 0.18 12.2 9.9 1.7 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Sec34 PF04136.15 KOG99964.1 - 0.5 10.2 7.0 1.6 8.6 5.1 2.1 1 1 1 2 2 2 0 Sec34-like family JIP_LZII PF16471.5 KOG99964.1 - 0.6 10.3 5.4 0.19 11.9 0.8 2.3 2 1 1 3 3 2 0 JNK-interacting protein leucine zipper II UPF0242 PF06785.11 KOG99964.1 - 0.65 10.1 10.8 0.77 9.8 10.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FUSC PF04632.12 KOG99964.1 - 1.1 7.8 15.2 1.2 7.6 15.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Jnk-SapK_ap_N PF09744.9 KOG99964.1 - 1.1 9.5 13.4 1.8 8.7 13.1 1.5 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Cep57_MT_bd PF06657.13 KOG99964.1 - 1.1 9.8 11.3 0.17 12.4 5.7 2.5 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 TipAS PF07739.13 KOG99964.1 - 1.2 9.7 8.4 5.3 7.6 2.6 2.2 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain T3SSipB PF16535.5 KOG99964.1 - 1.2 9.6 10.2 1.8 9.0 10.2 1.3 1 1 0 1 1 1 0 Type III cell invasion protein SipB Prefoldin PF02996.17 KOG99964.1 - 1.4 8.9 6.5 0.51 10.3 0.8 2.4 1 1 1 2 2 2 0 Prefoldin subunit YlqD PF11068.8 KOG99964.1 - 1.5 9.2 14.2 1.2 9.5 12.9 1.6 1 1 0 1 1 1 0 YlqD protein NPV_P10 PF05531.12 KOG99964.1 - 1.6 9.2 7.2 3.4 8.2 3.1 2.5 2 1 0 2 2 1 0 Nucleopolyhedrovirus P10 protein 5_nucleotid PF05761.14 KOG99964.1 - 2.4 7.0 6.0 2.8 6.8 6.0 1.1 1 0 0 1 1 1 0 5' nucleotidase family Spc24 PF08286.11 KOG99964.1 - 2.9 8.2 7.5 13 6.1 7.4 2.1 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 SlyX PF04102.12 KOG99964.1 - 3.7 8.2 22.4 0.89 10.2 8.3 3.0 1 1 2 3 3 3 0 SlyX TEX13 PF15186.6 KOG99964.1 - 4.7 6.9 14.0 5.1 6.8 13.3 1.4 1 1 0 1 1 1 0 Testis-expressed sequence 13 protein family HAUS6_N PF14661.6 KOG99964.1 - 7.1 6.1 12.9 16 5.0 12.9 1.6 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus ZapB PF06005.12 KOG99964.1 - 9.3 6.8 17.1 8.2e+02 0.5 17.1 2.6 1 1 0 1 1 1 0 Cell division protein ZapB Exo_endo_phos PF03372.23 KOG99965.1 - 5.5e-16 58.8 0.0 7.9e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family S_4TM PF18159.1 KOG99965.1 - 0.067 12.5 1.3 0.12 11.6 1.3 1.4 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain Sec61_beta PF03911.16 KOG99966.1 - 1.2e-14 54.0 0.6 1.5e-14 53.8 0.6 1.1 1 0 0 1 1 1 1 Sec61beta family G-alpha PF00503.20 KOG99967.1 - 4.5e-106 355.0 1.2 5.7e-106 354.6 1.2 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KOG99967.1 - 5.3e-16 58.6 1.1 2.6e-10 40.0 0.3 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 KOG99967.1 - 0.00058 20.1 0.3 1.5 9.1 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KOG99967.1 - 0.0008 18.8 0.4 0.083 12.2 0.1 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region FtsK_SpoIIIE PF01580.18 KOG99967.1 - 0.085 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 KOG99967.1 - 0.13 12.0 0.1 0.46 10.3 0.1 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain Ras PF00071.22 KOG99967.1 - 0.14 11.7 0.6 20 4.7 0.2 2.6 2 1 0 2 2 2 0 Ras family Spt20 PF12090.8 KOG99967.1 - 3.1 7.3 11.9 6.8 6.2 11.9 1.6 1 0 0 1 1 1 0 Spt20 family PCI PF01399.27 KOG99968.1 - 1.1e-20 74.1 2.4 2.6e-20 72.9 0.5 2.5 2 0 0 2 2 2 1 PCI domain Rpn3_C PF08375.11 KOG99968.1 - 7.4e-19 67.9 4.2 7.4e-19 67.9 4.2 2.0 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal HTH_27 PF13463.6 KOG99968.1 - 0.075 13.5 0.3 0.22 12.1 0.1 2.0 2 0 0 2 2 2 0 Winged helix DNA-binding domain DUF2209 PF09974.9 KOG99968.1 - 0.15 12.4 0.0 0.39 11.0 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Med17 PF10156.9 KOG99969.1 - 1.7e-175 584.2 25.4 1.7e-175 584.2 25.4 1.5 1 1 0 1 1 1 1 Subunit 17 of Mediator complex P5CR_dimer PF14748.6 KOG99970.1 - 8.5e-33 112.7 1.2 1.4e-32 112.0 0.5 1.7 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 KOG99970.1 - 5.7e-11 42.9 0.3 1.6e-10 41.4 0.3 1.8 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Carn_acyltransf PF00755.20 KOG99971.1 - 6e-113 378.5 0.2 2.3e-112 376.6 0.0 1.8 2 0 0 2 2 2 1 Choline/Carnitine o-acyltransferase Rrp44_CSD1 PF17216.3 KOG99971.1 - 2 8.1 5.8 0.62 9.8 1.3 2.6 2 1 0 2 2 2 0 Rrp44-like cold shock domain eIF2_C PF09173.11 KOG99972.1 - 1.2e-34 118.4 0.3 2.8e-34 117.2 0.3 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 KOG99972.1 - 3.5e-23 82.2 0.1 3.6e-22 78.9 0.1 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KOG99972.1 - 8e-12 45.4 0.5 2.9e-11 43.6 0.5 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOG99972.1 - 0.0029 17.6 0.0 0.0061 16.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOG99972.1 - 0.0044 16.9 0.1 0.049 13.5 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1_Xtn PF16897.5 KOG99972.1 - 0.037 14.0 0.1 0.089 12.8 0.1 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain CDP-OH_P_transf PF01066.21 KOG99973.1 - 4.6e-11 43.3 0.3 4.6e-11 43.3 0.3 2.0 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase CclA_1 PF16942.5 KOG99973.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Putative cyclic bacteriocin AMPKBI PF04739.15 KOG99974.1 - 8.7e-29 99.6 3.3 4.1e-28 97.4 3.3 2.2 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 KOG99974.1 - 1.5e-28 98.8 0.0 4.3e-28 97.4 0.0 1.8 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase zf-C2H2 PF00096.26 KOG99975.1 - 1.2e-06 28.7 17.3 0.00024 21.4 2.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOG99975.1 - 4.7e-06 27.0 14.3 0.0036 18.0 1.7 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOG99975.1 - 3.9e-05 23.9 17.6 0.00011 22.4 7.0 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KOG99975.1 - 0.00057 20.1 4.8 0.31 11.4 2.1 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding PreAtp-grasp PF18604.1 KOG99975.1 - 0.24 11.0 0.7 5.6 6.6 0.1 2.2 2 0 0 2 2 2 0 Pre ATP-grasp domain zf-C2HE PF16278.5 KOG99975.1 - 0.86 10.1 4.8 15 6.2 0.8 2.5 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger LSM PF01423.22 KOG99976.1 - 4.8e-21 74.2 0.2 7.5e-21 73.6 0.2 1.3 1 0 0 1 1 1 1 LSM domain Presenilin PF01080.17 KOG99976.1 - 5.3 5.7 4.2 6.3 5.4 4.2 1.1 1 0 0 1 1 1 0 Presenilin CHZ PF09649.10 KOG99977.1 - 1.3e-19 69.3 2.8 1.3e-19 69.3 2.8 2.4 3 0 0 3 3 3 1 Histone chaperone domain CHZ TT_ORF2 PF02957.15 KOG99977.1 - 0.99 10.3 16.0 0.28 12.1 7.6 2.2 2 0 0 2 2 2 0 TT viral ORF2 Ras PF00071.22 KOG99978.1 - 1.5e-61 206.8 0.2 1.7e-61 206.5 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOG99978.1 - 2.1e-34 118.3 0.1 3.5e-34 117.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOG99978.1 - 1.1e-13 51.0 0.0 1.5e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOG99978.1 - 1.1e-06 28.6 0.1 2.3e-06 27.7 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase KAP_NTPase PF07693.14 KOG99978.1 - 0.00032 20.0 0.0 0.00047 19.5 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain Gtr1_RagA PF04670.12 KOG99978.1 - 0.00038 19.9 0.1 0.00049 19.5 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOG99978.1 - 0.00046 19.8 0.0 0.0027 17.3 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KOG99978.1 - 0.0016 18.4 0.1 0.018 14.9 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 KOG99978.1 - 0.0079 16.5 0.1 0.069 13.4 0.0 2.2 1 1 1 2 2 2 1 AAA domain PduV-EutP PF10662.9 KOG99978.1 - 0.024 14.4 0.0 0.042 13.6 0.0 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 KOG99978.1 - 0.027 14.2 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 KOG99978.1 - 0.028 13.9 0.2 0.15 11.4 0.0 1.9 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 KOG99978.1 - 0.029 14.9 1.3 0.1 13.1 1.3 1.9 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 KOG99978.1 - 0.031 14.7 0.1 0.051 13.9 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 KOG99978.1 - 0.054 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Septin GCP_N_terminal PF17681.1 KOG99978.1 - 0.061 13.0 0.0 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 Gamma tubulin complex component N-terminal FeoB_N PF02421.18 KOG99978.1 - 0.076 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_7 PF12775.7 KOG99978.1 - 0.09 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 KOG99978.1 - 0.09 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein MCM PF00493.23 KOG99978.1 - 0.1 11.7 0.0 0.22 10.6 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain AAA_18 PF13238.6 KOG99978.1 - 0.12 12.9 0.4 0.85 10.2 0.1 2.2 1 1 1 2 2 2 0 AAA domain AAA_21 PF13304.6 KOG99978.1 - 0.15 11.8 0.6 0.23 11.2 0.5 1.3 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ATPgrasp_YheCD PF14398.6 KOG99979.1 - 0.0029 16.9 0.2 0.015 14.6 0.0 2.2 3 0 0 3 3 3 1 YheC/D like ATP-grasp DUF5364 PF17322.2 KOG99981.1 - 7.5e-57 192.6 18.4 8.5e-57 192.5 18.4 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5364) TipE PF16972.5 KOG99981.1 - 0.086 12.0 5.0 0.11 11.7 5.0 1.0 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE PNRC PF15365.6 KOG99982.1 - 0.00041 20.1 0.2 0.00041 20.1 0.2 2.1 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator motif BRF1 PF07741.13 KOG99982.1 - 1.4 9.3 4.9 2.6 8.4 4.9 1.6 1 1 0 1 1 1 0 Brf1-like TBP-binding domain ABC_tran PF00005.27 KOG99983.1 - 1.6e-49 168.0 0.0 3.9e-25 88.9 0.0 2.8 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 KOG99983.1 - 2.5e-21 75.5 2.8 2.5e-21 75.5 2.8 2.9 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.6 KOG99983.1 - 1.7e-20 74.1 4.2 5.4e-07 29.7 0.0 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOG99983.1 - 6.6e-10 38.8 0.9 0.58 9.5 0.0 4.5 3 1 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOG99983.1 - 3.6e-08 34.2 6.2 0.0078 16.7 0.0 4.0 4 0 0 4 4 4 2 AAA domain RsgA_GTPase PF03193.16 KOG99983.1 - 5.8e-08 32.8 0.1 0.0006 19.8 0.0 3.3 3 0 0 3 3 3 1 RsgA GTPase AAA_29 PF13555.6 KOG99983.1 - 1.1e-07 31.5 0.0 0.0043 16.8 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 KOG99983.1 - 2.2e-06 27.6 3.7 0.089 12.5 0.0 4.0 4 1 0 5 5 5 2 AAA ATPase domain AAA_22 PF13401.6 KOG99983.1 - 3.6e-06 27.3 0.0 0.052 13.8 0.0 3.0 3 1 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 KOG99983.1 - 3.6e-06 27.0 0.0 0.0092 16.1 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 KOG99983.1 - 9.9e-06 26.0 0.0 0.026 14.9 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.6 KOG99983.1 - 1.3e-05 25.8 0.1 0.037 14.6 0.0 3.4 4 0 0 4 4 2 1 AAA domain RNA_helicase PF00910.22 KOG99983.1 - 2.9e-05 24.4 0.0 0.3 11.5 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 KOG99983.1 - 3.4e-05 24.1 0.0 0.14 12.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 KOG99983.1 - 3.7e-05 24.2 0.1 0.21 12.0 0.0 3.2 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KOG99983.1 - 4.5e-05 23.6 0.0 0.14 12.3 0.0 3.0 3 0 0 3 3 3 2 AAA domain NACHT PF05729.12 KOG99983.1 - 5.5e-05 23.1 1.0 0.32 10.9 0.0 3.0 3 0 0 3 3 2 2 NACHT domain AAA_24 PF13479.6 KOG99983.1 - 0.00014 21.6 0.3 0.28 10.9 0.0 3.3 3 0 0 3 3 3 1 AAA domain MCM PF00493.23 KOG99983.1 - 0.0003 20.0 0.1 0.45 9.6 0.0 2.9 3 0 0 3 3 2 2 MCM P-loop domain Rad17 PF03215.15 KOG99983.1 - 0.00036 20.5 0.0 0.38 10.7 0.0 2.7 3 0 0 3 3 2 1 Rad17 P-loop domain AAA_14 PF13173.6 KOG99983.1 - 0.0011 19.0 0.0 3.2 7.8 0.0 3.0 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 KOG99983.1 - 0.0013 18.8 1.7 9.3 6.3 0.0 4.1 3 1 0 4 4 4 0 Dynamin family Roc PF08477.13 KOG99983.1 - 0.003 17.8 0.0 1.2 9.4 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 KOG99983.1 - 0.0031 17.5 0.0 3.3 7.7 0.1 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 KOG99983.1 - 0.0069 16.0 0.0 1.1 8.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain VirE PF05272.11 KOG99983.1 - 0.0072 16.1 0.1 1.3 8.8 0.0 3.0 3 0 0 3 3 3 1 Virulence-associated protein E NB-ARC PF00931.22 KOG99983.1 - 0.0083 15.3 0.1 0.77 8.9 0.0 3.2 3 0 0 3 3 3 1 NB-ARC domain DUF815 PF05673.13 KOG99983.1 - 0.011 14.9 0.1 6.3 5.9 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF815) G-alpha PF00503.20 KOG99983.1 - 0.012 14.9 0.2 2.6 7.1 0.0 3.0 3 0 0 3 3 3 0 G-protein alpha subunit MeaB PF03308.16 KOG99983.1 - 0.014 14.4 0.2 1.9 7.4 0.0 2.6 3 0 0 3 3 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_7 PF12775.7 KOG99983.1 - 0.018 14.6 0.1 1.2 8.6 0.0 2.7 3 0 0 3 3 2 0 P-loop containing dynein motor region TsaE PF02367.17 KOG99983.1 - 0.021 14.9 1.7 2.2 8.3 0.0 3.2 3 1 1 4 4 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 KOG99983.1 - 0.021 14.6 0.0 0.47 10.2 0.0 2.7 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_27 PF13514.6 KOG99983.1 - 0.022 14.3 0.7 9.7 5.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain dNK PF01712.19 KOG99983.1 - 0.033 14.0 0.4 10 5.9 0.0 2.6 3 0 0 3 3 2 0 Deoxynucleoside kinase DUF87 PF01935.17 KOG99983.1 - 0.04 14.0 0.9 22 5.0 0.0 3.5 3 1 1 4 4 4 0 Helicase HerA, central domain CLP1_P PF16575.5 KOG99983.1 - 0.043 13.6 0.9 23 4.7 0.0 3.4 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop PduV-EutP PF10662.9 KOG99983.1 - 0.048 13.4 0.3 18 5.0 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 KOG99983.1 - 0.052 13.3 0.2 2.7 7.6 0.1 3.0 2 1 0 2 2 2 0 AAA domain FeoB_N PF02421.18 KOG99983.1 - 0.056 13.0 0.0 2.9 7.4 0.0 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B DUF2813 PF11398.8 KOG99983.1 - 0.092 12.0 0.5 5.5 6.1 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2813) NTPase_1 PF03266.15 KOG99983.1 - 0.1 12.5 1.5 1.7 8.5 0.1 2.9 3 0 0 3 3 3 0 NTPase AAA_17 PF13207.6 KOG99983.1 - 0.2 12.1 3.0 20 5.6 0.0 3.7 4 0 0 4 4 4 0 AAA domain HAD_2 PF13419.6 KOG99984.1 - 9.8e-08 32.3 0.1 1.8e-07 31.4 0.1 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOG99984.1 - 3.8e-06 27.4 0.0 2.5e-05 24.7 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Nse5 PF08691.10 KOG99985.1 - 9.8e-61 206.0 24.3 1.1e-60 205.7 24.3 1.0 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 EamA PF00892.20 KOG99986.1 - 2.6e-09 37.4 28.7 6.5e-05 23.1 7.5 2.1 2 0 0 2 2 2 2 EamA-like transporter family GATA PF00320.27 KOG99987.1 - 1.1e-15 56.9 4.0 1.1e-15 56.9 4.0 1.9 2 0 0 2 2 2 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 KOG99987.1 - 0.15 11.6 0.6 0.3 10.7 0.6 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding XPG_I PF00867.18 KOG99988.1 - 2.7e-22 78.9 0.0 7.7e-22 77.5 0.0 1.9 1 0 0 1 1 1 1 XPG I-region PMSR PF01625.21 KOG99989.1 - 5.6e-52 176.0 0.1 7e-52 175.7 0.1 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Edc3_linker PF16598.5 KOG99989.1 - 0.17 12.6 0.0 0.31 11.7 0.0 1.4 1 0 0 1 1 1 0 Linker region of enhancer of mRNA-decapping protein 3 AdoHcyase PF05221.17 KOG99990.1 - 1.5e-130 434.7 0.0 2e-74 250.4 0.2 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KOG99990.1 - 1.3e-84 282.2 2.7 2e-84 281.6 2.7 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 KOG99990.1 - 1.3e-06 27.9 0.1 2.5e-06 27.0 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 KOG99990.1 - 0.0007 19.8 0.1 0.0013 18.9 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain IlvN PF07991.12 KOG99990.1 - 0.0012 18.4 0.3 0.0022 17.6 0.3 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain PALP PF00291.25 KOG99990.1 - 0.12 11.8 0.9 0.36 10.2 0.4 1.8 2 0 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme Erg28 PF03694.13 KOG99991.1 - 5.6e-44 149.0 1.9 7.3e-44 148.7 1.9 1.1 1 0 0 1 1 1 1 Erg28 like protein MtN3_slv PF03083.16 KOG99991.1 - 0.0017 18.3 1.5 0.0035 17.3 0.8 1.9 1 1 1 2 2 2 1 Sugar efflux transporter for intercellular exchange Mei4 PF13971.6 KOG99992.1 - 1.1e-36 127.0 5.9 1.4e-36 126.8 5.9 1.0 1 0 0 1 1 1 1 Meiosis-specific protein Mei4 THAP PF05485.12 KOG99992.1 - 0.02 15.8 0.2 0.037 15.0 0.2 1.4 1 0 0 1 1 1 0 THAP domain bZIP_1 PF00170.21 KOG99993.1 - 2.8e-17 62.6 11.6 5.1e-17 61.7 11.6 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KOG99993.1 - 8.9e-07 28.9 6.7 2.3e-06 27.6 6.7 1.7 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 KOG99993.1 - 0.014 15.9 5.2 0.043 14.3 5.2 1.8 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF3446 PF11928.8 KOG99993.1 - 0.027 14.8 12.7 0.027 14.8 12.7 4.8 4 1 2 6 6 6 0 Early growth response N-terminal domain AAA PF00004.29 KOG99995.1 - 2.4e-39 134.8 0.0 5.6e-39 133.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOG99995.1 - 5.9e-09 35.6 0.0 1.2e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 KOG99995.1 - 1.4e-07 31.4 0.0 8.5e-07 28.9 0.0 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.6 KOG99995.1 - 2.3e-05 24.7 0.2 0.001 19.4 0.2 2.8 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KOG99995.1 - 7.2e-05 22.6 0.0 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 KOG99995.1 - 0.00011 22.4 0.2 0.00049 20.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KOG99995.1 - 0.00085 19.8 0.2 0.0072 16.7 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 KOG99995.1 - 0.00096 18.5 0.0 0.0019 17.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain TFIIA PF03153.13 KOG99995.1 - 0.0014 18.7 6.8 0.0014 18.7 6.8 2.3 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit AAA_5 PF07728.14 KOG99995.1 - 0.0018 18.3 1.3 0.0055 16.7 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KOG99995.1 - 0.0028 17.7 1.1 0.02 14.9 0.0 2.8 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 KOG99995.1 - 0.0035 16.8 0.1 0.012 15.0 0.1 1.9 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 KOG99995.1 - 0.0039 16.8 0.2 0.41 10.2 0.0 2.4 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KOG99995.1 - 0.0084 15.9 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 KOG99995.1 - 0.013 14.7 0.0 0.028 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 KOG99995.1 - 0.015 15.9 0.1 0.18 12.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KOG99995.1 - 0.029 14.5 0.0 0.1 12.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain Chromo PF00385.24 KOG99995.1 - 0.084 12.8 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain NACHT PF05729.12 KOG99995.1 - 0.12 12.3 0.0 0.38 10.7 0.0 1.9 1 0 0 1 1 1 0 NACHT domain DnaJ-X PF14308.6 KOG99996.1 - 4.3e-59 199.5 10.0 8e-59 198.6 10.0 1.4 1 0 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.31 KOG99996.1 - 2.1e-25 88.6 3.5 5.8e-25 87.2 0.9 3.0 3 0 0 3 3 3 1 DnaJ domain DSPn PF14671.6 KOG99996.1 - 0.13 12.8 0.3 0.39 11.2 0.1 1.9 2 1 0 2 2 2 0 Dual specificity protein phosphatase, N-terminal half YkuI_C PF10388.9 KOG99996.1 - 0.13 12.0 2.9 0.26 11.1 2.9 1.5 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain DUF3456 PF11938.8 KOG99996.1 - 0.81 10.2 5.4 7.5 7.0 1.0 2.3 2 0 0 2 2 2 0 TLR4 regulator and MIR-interacting MSAP YtxH PF12732.7 KOG99996.1 - 3.2 8.3 9.1 0.95 10.0 4.0 2.7 3 0 0 3 3 3 0 YtxH-like protein TipAS PF07739.13 KOG99996.1 - 7.5 7.1 8.2 1 9.9 1.4 2.9 2 2 1 3 3 3 0 TipAS antibiotic-recognition domain Complex1_LYR PF05347.15 KOG99997.1 - 6.4e-19 67.8 0.5 7.8e-19 67.5 0.5 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KOG99997.1 - 0.0025 18.5 0.8 0.0028 18.4 0.8 1.1 1 0 0 1 1 1 1 Complex1_LYR-like MIF4G PF02854.19 KOG99997.1 - 0.019 14.6 0.2 0.02 14.6 0.2 1.1 1 0 0 1 1 1 0 MIF4G domain Complex1_LYR_1 PF13232.6 KOG99997.1 - 0.027 15.1 0.0 0.032 14.8 0.0 1.2 1 0 0 1 1 1 0 Complex1_LYR-like DUF3038 PF11237.8 KOG99997.1 - 0.11 12.5 0.6 0.12 12.5 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3038) Ofd1_CTDD PF10637.9 KOG99998.1 - 2.1e-96 322.2 1.2 1.4e-94 316.3 1.0 2.3 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 KOG99998.1 - 1.2e-25 90.0 0.0 4.1e-25 88.3 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 KOG99998.1 - 1.1e-13 51.9 0.0 2.4e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KOG99998.1 - 0.0064 17.0 0.1 0.036 14.6 0.0 2.3 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Ribosomal_S18 PF01084.20 KOG99999.1 - 4.8e-17 61.9 0.3 9e-17 61.0 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 Cupin_8 PF13621.6 KOH00001.1 - 1.4e-06 28.2 2.2 2.6e-05 24.1 2.2 2.2 1 1 0 1 1 1 1 Cupin-like domain PHD PF00628.29 KOH00001.1 - 2.6e-05 24.0 2.4 5.3e-05 23.0 2.4 1.6 1 0 0 1 1 1 1 PHD-finger JmjC PF02373.22 KOH00001.1 - 0.00023 21.6 0.3 0.19 12.2 0.0 3.9 3 1 0 3 3 3 1 JmjC domain, hydroxylase C1_1 PF00130.22 KOH00001.1 - 0.0086 15.9 5.2 0.019 14.8 5.2 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) JHD PF17811.1 KOH00001.1 - 0.019 15.5 0.1 0.076 13.6 0.0 2.0 2 0 0 2 2 2 0 Jumonji helical domain Cupin_4 PF08007.12 KOH00001.1 - 0.031 13.8 0.0 0.066 12.7 0.0 1.5 1 0 0 1 1 1 0 Cupin superfamily protein PHD_Oberon PF07227.11 KOH00001.1 - 0.035 14.0 0.7 0.071 13.0 0.7 1.5 1 0 0 1 1 1 0 PHD - plant homeodomain finger protein Cupin_1 PF00190.22 KOH00001.1 - 0.045 13.4 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 Cupin Cupin_2 PF07883.11 KOH00001.1 - 0.069 12.9 0.0 0.26 11.0 0.0 1.9 2 0 0 2 2 2 0 Cupin domain AA_kinase PF00696.28 KOH00002.1 - 2.6e-40 138.6 0.0 4.5e-40 137.8 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.25 KOH00002.1 - 1.9e-11 43.5 1.5 0.00019 21.1 0.3 3.1 2 1 0 2 2 2 2 ACT domain ACT_7 PF13840.6 KOH00002.1 - 1.1e-08 34.7 1.2 1.5e-06 27.9 0.2 2.5 2 0 0 2 2 2 2 ACT domain Mito_carr PF00153.27 KOH00003.1 - 4.7e-44 148.2 5.3 3e-16 59.1 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein CBM_21 PF03370.13 KOH00005.1 - 2e-29 102.0 1.0 6.7e-29 100.3 1.0 2.0 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 KOH00005.1 - 2.6e-12 47.1 1.1 2.6e-12 47.1 1.1 3.2 4 0 0 4 4 4 1 Starch/carbohydrate-binding module (family 53) Stm1_N PF09598.10 KOH00005.1 - 0.87 10.5 4.8 14 6.6 0.3 2.9 3 0 0 3 3 3 0 Stm1 HisG PF01634.18 KOH00006.1 - 9.2e-52 175.2 0.1 1.2e-51 174.9 0.1 1.1 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 KOH00006.1 - 2.5e-25 88.4 0.0 4.2e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 HisG, C-terminal domain Transp_cyt_pur PF02133.15 KOH00007.1 - 3.1e-116 388.7 45.1 3.6e-116 388.5 45.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin VIT1 PF01988.19 KOH00007.1 - 2.1 8.2 9.3 0.046 13.6 0.4 2.6 3 0 0 3 3 3 0 VIT family Ribonuc_L-PSP PF01042.21 KOH00008.1 - 4.6e-43 146.1 0.9 5.1e-43 145.9 0.9 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP PET117 PF15786.5 KOH00009.1 - 6.8e-33 112.8 0.4 9e-33 112.4 0.4 1.2 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial Phage_cap_E PF03864.15 KOH00009.1 - 0.0056 15.9 0.2 0.0062 15.8 0.2 1.0 1 0 0 1 1 1 1 Phage major capsid protein E Cyclin PF08613.11 KOH00010.1 - 3.1e-46 157.7 7.7 4.3e-26 92.2 0.1 3.2 3 1 1 4 4 4 2 Cyclin Transp_cyt_pur PF02133.15 KOH00011.1 - 6.7e-118 394.2 42.9 8.2e-118 393.9 42.9 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF2678 PF10856.8 KOH00011.1 - 0.43 10.5 6.1 0.4 10.6 2.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) Transp_cyt_pur PF02133.15 KOH00012.1 - 2.5e-115 385.8 43.4 2.9e-115 385.6 43.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin ketoacyl-synt PF00109.26 KOH00013.1 - 3.1e-58 197.3 0.0 1e-57 195.6 0.0 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 KOH00013.1 - 1.2e-34 118.8 0.1 2e-34 118.1 0.1 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 KOH00013.1 - 0.0091 15.4 0.2 0.035 13.5 0.1 1.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain HAD_2 PF13419.6 KOH00014.1 - 1.6e-15 57.7 0.0 2.1e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOH00014.1 - 3.1e-12 47.2 0.0 3.8e-10 40.4 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOH00014.1 - 0.0015 19.0 0.0 0.0026 18.2 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOH00014.1 - 0.0072 16.4 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Tho1_MOS11_C PF18592.1 KOH00015.1 - 1.1e-26 92.4 0.9 2.1e-26 91.5 0.9 1.5 1 0 0 1 1 1 1 Tho1/MOS11 C-terminal domain SAP PF02037.27 KOH00015.1 - 2.7e-12 46.1 0.6 4.5e-12 45.4 0.6 1.4 1 0 0 1 1 1 1 SAP domain DUF2868 PF11067.8 KOH00015.1 - 4.7 6.6 5.5 7.7 5.9 5.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2868) CENP-H PF05837.12 KOH00015.1 - 6.8 7.1 9.4 6.6 7.2 0.9 2.4 2 1 0 2 2 2 0 Centromere protein H (CENP-H) Vhr1 PF04001.13 KOH00016.1 - 3e-45 152.4 1.3 5.8e-45 151.5 1.3 1.5 1 0 0 1 1 1 1 Transcription factor Vhr1 PHC2_SAM_assoc PF16616.5 KOH00016.1 - 4.3 8.2 13.2 0.13 13.1 6.4 1.9 2 0 0 2 2 2 0 Unstructured region on Polyhomeotic-like protein 1 and 2 ICL PF00463.21 KOH00017.1 - 2.7e-301 999.6 0.3 3.1e-301 999.4 0.3 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 KOH00017.1 - 1.4e-09 37.8 0.0 2.5e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase RGI1 PF10843.8 KOH00018.1 - 2e-34 118.9 9.0 3.7e-34 118.1 9.0 1.4 1 1 0 1 1 1 1 Respiratory growth induced protein 1 DIX PF00778.17 KOH00018.1 - 0.0059 16.4 1.7 0.0083 15.9 0.2 2.0 2 0 0 2 2 2 1 DIX domain Adeno_100 PF02438.16 KOH00018.1 - 0.01 14.0 0.0 0.015 13.5 0.0 1.2 1 0 0 1 1 1 0 Late 100kD protein zf-RING_4 PF14570.6 KOH00019.1 - 1.9e-20 72.4 13.5 3.6e-20 71.5 13.5 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 KOH00019.1 - 2.5e-07 30.4 7.8 5.3e-07 29.4 7.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 KOH00019.1 - 2.6e-06 27.0 0.7 5.7e-06 25.9 0.7 1.5 1 0 0 1 1 1 1 Rtf2 RING-finger RRM_1 PF00076.22 KOH00019.1 - 6.1e-06 26.0 0.1 0.0001 22.1 0.1 2.4 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Baculo_IE-1 PF05290.11 KOH00019.1 - 5e-05 23.3 3.0 0.00011 22.1 3.0 1.5 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_2 PF13639.6 KOH00019.1 - 0.0007 19.9 10.1 0.0015 18.9 10.1 1.6 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KOH00019.1 - 0.005 16.7 8.7 0.13 12.2 9.6 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 SET_assoc PF11767.8 KOH00019.1 - 0.0068 16.0 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated zf-C3HC4 PF00097.25 KOH00019.1 - 0.0085 15.9 10.9 0.019 14.8 10.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.6 KOH00019.1 - 0.13 12.4 5.3 0.31 11.2 5.3 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_5 PF14634.6 KOH00019.1 - 0.24 11.4 9.7 0.52 10.3 9.7 1.6 1 0 0 1 1 1 0 zinc-RING finger domain PocR PF10114.9 KOH00019.1 - 0.25 11.1 3.8 0.35 10.6 1.8 2.1 2 0 0 2 2 2 0 Sensory domain found in PocR zf-RING_UBOX PF13445.6 KOH00019.1 - 2.1 8.5 8.9 3.2 7.8 8.0 1.8 1 1 0 1 1 1 0 RING-type zinc-finger NAT PF04768.13 KOH00020.1 - 1.4e-53 181.0 0.3 4e-53 179.6 0.1 1.9 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 KOH00020.1 - 2.7e-31 108.5 0.0 5.4e-31 107.5 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 KOH00020.1 - 5.9e-25 88.3 0.0 1.2e-24 87.2 0.0 1.5 1 0 0 1 1 1 1 Amino acid kinase family DapB_N PF01113.20 KOH00020.1 - 0.019 15.0 0.0 0.056 13.6 0.0 1.8 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus vATP-synt_E PF01991.18 KOH00020.1 - 0.11 12.0 0.0 0.26 10.7 0.0 1.6 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Ribonuc_red_lgC PF02867.15 KOH00021.1 - 3.6e-184 613.2 0.0 4.6e-184 612.8 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 KOH00021.1 - 1.8e-23 82.3 0.0 5e-23 80.9 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 KOH00021.1 - 5.7e-16 58.9 0.0 1.9e-15 57.2 0.0 2.0 1 0 0 1 1 1 1 ATP cone domain Tctex-1 PF03645.13 KOH00022.1 - 7.2e-07 29.4 0.1 8.4e-07 29.2 0.1 1.1 1 0 0 1 1 1 1 Tctex-1 family DUF202 PF02656.15 KOH00023.1 - 2.5e-14 53.5 4.4 3.3e-14 53.1 3.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF5337 PF17272.2 KOH00023.1 - 0.33 10.8 2.8 0.86 9.5 2.8 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5337) Aldedh PF00171.22 KOH00024.1 - 2.9e-184 612.9 0.9 3.2e-184 612.7 0.9 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Beta_lactamase3 PF17030.5 KOH00024.1 - 0.086 12.1 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Putative beta-lactamase-like family CitG PF01874.16 KOH00024.1 - 0.11 12.2 0.1 0.26 10.9 0.0 1.6 2 0 0 2 2 2 0 ATP:dephospho-CoA triphosphoribosyl transferase Ribosomal_S24e PF01282.19 KOH00025.1 - 2.8e-35 120.1 0.1 4.5e-35 119.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e RAMPs PF03787.15 KOH00025.1 - 0.026 14.6 0.4 1.5 8.8 0.0 2.1 2 0 0 2 2 2 0 RAMP superfamily Yos1 PF08571.10 KOH00026.1 - 4.6e-16 58.8 0.2 4.8e-16 58.8 0.2 1.0 1 0 0 1 1 1 1 Yos1-like TMEM191C PF15194.6 KOH00026.1 - 0.039 14.1 0.0 0.041 14.1 0.0 1.0 1 0 0 1 1 1 0 TMEM191C family Y_phosphatase PF00102.27 KOH00027.1 - 1.5e-48 165.4 0.0 1.5e-47 162.1 0.0 2.1 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 KOH00027.1 - 1.6e-08 35.0 0.0 7e-08 32.9 0.0 2.1 1 0 0 1 1 1 1 Rhodanese-like domain DSPc PF00782.20 KOH00027.1 - 0.0024 17.7 0.0 0.011 15.6 0.0 2.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KOH00027.1 - 0.061 13.3 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family PPR_2 PF13041.6 KOH00028.1 - 5.2e-13 49.0 4.9 2.8e-09 37.0 0.0 4.1 3 1 1 4 4 4 2 PPR repeat family Peptidase_M24 PF00557.24 KOH00029.1 - 2.5e-51 174.3 0.0 3.4e-51 173.9 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 KOH00029.1 - 1.4e-35 121.7 0.0 4.3e-35 120.1 0.0 1.8 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain APH PF01636.23 KOH00031.1 - 9.1e-08 32.3 0.0 8.2e-07 29.2 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family LidA_Long_CC PF18641.1 KOH00031.1 - 0.0025 17.9 0.7 0.0071 16.4 0.7 1.8 1 0 0 1 1 1 1 LidA long coiled-coil domain Choline_kinase PF01633.20 KOH00031.1 - 0.014 15.0 0.1 0.048 13.2 0.0 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.14 KOH00031.1 - 0.021 14.2 0.0 4.7 6.5 0.0 2.7 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L21e PF01157.18 KOH00031.1 - 0.13 12.2 0.1 0.29 11.0 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein L21e 2-Hacid_dh_C PF02826.19 KOH00032.1 - 3.3e-52 176.4 0.0 5.4e-52 175.7 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOH00032.1 - 6.4e-39 132.7 0.0 8.5e-39 132.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KOH00032.1 - 1.1e-05 25.7 1.4 1.9e-05 24.9 0.2 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 KOH00032.1 - 0.00044 20.4 0.0 0.00087 19.4 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ACT PF01842.25 KOH00032.1 - 0.0037 17.0 0.0 0.011 15.4 0.0 1.8 1 0 0 1 1 1 1 ACT domain DUF262 PF03235.14 KOH00032.1 - 0.033 14.4 0.1 0.055 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF262 XdhC_C PF13478.6 KOH00032.1 - 0.043 14.3 0.0 0.11 13.0 0.0 1.7 2 0 0 2 2 2 0 XdhC Rossmann domain 3HCDH_N PF02737.18 KOH00032.1 - 0.13 12.1 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain BING4CT PF08149.11 KOH00033.1 - 2.4e-38 129.8 0.2 1.3e-35 121.0 0.0 3.9 4 0 0 4 4 4 1 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 KOH00033.1 - 2.7e-06 27.6 0.0 1.5 9.2 0.0 5.3 3 1 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOH00033.1 - 9.7e-05 23.1 0.3 0.085 13.8 0.0 4.4 4 1 0 4 4 4 1 WD domain, G-beta repeat GET2 PF08690.10 KOH00034.1 - 3.3e-91 306.2 0.6 1e-65 222.4 0.0 2.0 1 1 1 2 2 2 2 GET complex subunit GET2 PALP PF00291.25 KOH00036.1 - 3.1e-78 263.2 0.1 4.3e-78 262.7 0.1 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 KOH00036.1 - 5.1e-42 141.6 0.0 1.4e-28 98.4 0.0 2.6 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase tRNA-synt_2b PF00587.25 KOH00037.1 - 1.1e-36 126.5 0.0 1.8e-36 125.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 KOH00037.1 - 0.036 14.2 0.0 0.081 13.1 0.0 1.5 1 0 0 1 1 1 0 Anticodon binding domain Sec61_beta PF03911.16 KOH00038.1 - 5.3e-16 58.4 1.1 6.4e-16 58.1 1.1 1.1 1 0 0 1 1 1 1 Sec61beta family Myb_DNA-binding PF00249.31 KOH00039.1 - 1.2e-13 51.0 1.3 1.3e-11 44.5 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOH00039.1 - 2.3e-11 43.8 1.4 8.7e-09 35.5 0.3 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain PP2C PF00481.21 KOH00041.1 - 6.4e-84 281.6 0.0 1e-83 281.0 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Chorismate_bind PF00425.18 KOH00042.1 - 7.3e-90 301.0 0.0 1.3e-88 296.9 0.0 2.1 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 KOH00042.1 - 2e-32 112.4 0.2 5.5e-30 104.5 0.0 3.6 3 1 1 4 4 4 1 Anthranilate synthase component I, N terminal region POR PF01558.18 KOH00042.1 - 0.089 12.9 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase RNase_P_pop3 PF08228.11 KOH00042.1 - 0.16 12.0 0.1 0.31 11.1 0.1 1.4 1 0 0 1 1 1 0 RNase P subunit Pop3 Meth_synt_2 PF01717.18 KOH00043.1 - 9.8e-154 511.4 0.0 8.7e-150 498.4 0.0 2.4 2 1 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 KOH00043.1 - 2.6e-124 414.8 0.0 3e-116 388.3 0.0 2.5 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain IES5 PF17335.2 KOH00044.1 - 3.1e-46 156.3 2.9 3.5e-46 156.1 2.9 1.0 1 0 0 1 1 1 1 Ino80 complex subunit 5 RICTOR_N PF14664.6 KOH00045.1 - 7.8e-100 334.5 12.0 1.4e-99 333.6 12.0 1.4 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 KOH00045.1 - 6.3e-32 109.4 7.0 1.7e-29 101.7 0.1 5.7 6 0 0 6 6 6 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 KOH00045.1 - 5.1e-31 106.7 0.8 2e-29 101.6 0.2 3.7 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 KOH00045.1 - 3.8e-30 104.4 3.1 3.1e-28 98.3 0.2 3.8 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF1664 PF07889.12 KOH00045.1 - 0.5 10.4 3.9 0.58 10.2 1.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Proteasome PF00227.26 KOH00046.1 - 8.6e-41 139.5 0.0 1e-40 139.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Rad51 PF08423.11 KOH00047.1 - 5.3e-127 422.4 0.0 6.5e-127 422.1 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 KOH00047.1 - 2.1e-12 47.1 0.0 3.2e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 KOH00047.1 - 2.1e-09 37.2 0.0 3.4e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 KOH00047.1 - 1e-08 35.7 0.6 2e-08 34.7 0.6 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 KOH00047.1 - 2.9e-05 23.5 0.0 6.5e-05 22.4 0.0 1.6 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 KOH00047.1 - 0.0098 15.3 0.0 0.04 13.2 0.0 1.8 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 KOH00047.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sel1 PF08238.12 KOH00048.1 - 5.5e-20 71.4 0.5 0.00015 22.3 0.1 4.5 4 0 0 4 4 4 4 Sel1 repeat UCH PF00443.29 KOH00049.1 - 6.9e-71 238.8 8.0 6.9e-71 238.8 8.0 1.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOH00049.1 - 2.4e-19 70.1 15.9 8.4e-16 58.4 4.9 3.2 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase SelP_N PF04592.14 KOH00049.1 - 0.98 8.8 22.6 1.7 8.0 8.9 2.4 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Pribosyltran_N PF13793.6 KOH00050.1 - 6.9e-44 148.5 0.1 8.9e-41 138.5 0.0 2.2 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 KOH00050.1 - 9.4e-37 126.8 1.8 4.1e-30 105.2 0.6 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 KOH00050.1 - 3.4e-16 59.2 0.7 1.9e-15 56.7 0.5 2.1 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KOH00050.1 - 0.0043 16.5 0.1 0.0062 16.0 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF2007 PF09413.10 KOH00050.1 - 0.16 12.2 0.0 0.4 10.9 0.0 1.7 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein UQ_con PF00179.26 KOH00051.1 - 1.4e-21 76.6 0.1 2.2e-21 76.0 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ADH_zinc_N_2 PF13602.6 KOH00052.1 - 1.3e-13 52.2 0.0 2.5e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOH00052.1 - 0.00019 21.3 0.0 0.00033 20.5 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Ribosomal_S8e PF01201.22 KOH00053.1 - 4.8e-57 192.0 2.4 6.5e-57 191.5 2.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e HSP70 PF00012.20 KOH00054.1 - 1.7e-259 862.1 10.9 1.9e-259 861.9 10.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOH00054.1 - 2.7e-18 65.9 0.0 3.3e-17 62.3 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 KOH00054.1 - 0.00017 21.4 0.0 0.00043 20.1 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 KOH00054.1 - 0.0039 16.5 0.0 0.014 14.7 0.0 2.1 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase BcrAD_BadFG PF01869.20 KOH00054.1 - 0.044 13.3 0.0 4.2 6.8 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family SOBP PF15279.6 KOH00055.1 - 1.1 9.9 7.9 1.3 9.5 7.9 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Nucleoporin_N PF08801.11 KOH00056.1 - 2.9e-109 365.7 11.7 2.9e-109 365.7 11.7 1.6 2 0 0 2 2 2 1 Nup133 N terminal like Nucleoporin_C PF03177.14 KOH00056.1 - 2.2e-88 297.5 1.8 2.2e-86 290.9 0.2 3.0 2 1 0 2 2 2 1 Non-repetitive/WGA-negative nucleoporin C-terminal MAM1 PF10434.9 KOH00057.1 - 3.6e-74 249.8 21.0 5.3e-74 249.2 21.0 1.2 1 0 0 1 1 1 1 Monopolin complex protein MAM1 Curto_V2 PF07325.11 KOH00057.1 - 3.4 7.6 7.0 2 8.3 1.8 2.8 1 1 2 3 3 3 0 Curtovirus V2 protein WD40 PF00400.32 KOH00058.1 - 1.8e-18 66.5 4.6 0.00013 22.6 0.2 4.8 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00058.1 - 1.2e-07 32.0 0.0 0.0036 17.6 0.0 4.2 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOH00058.1 - 0.0021 16.8 0.1 1.5 7.4 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KOH00058.1 - 0.053 12.5 0.0 2.2 7.2 0.0 2.4 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 KOH00058.1 - 0.11 10.8 0.1 0.31 9.3 0.1 1.6 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz LisH PF08513.11 KOH00059.1 - 0.00018 21.3 0.1 0.00033 20.5 0.1 1.5 1 0 0 1 1 1 1 LisH IBN_N PF03810.19 KOH00060.1 - 4e-16 58.7 4.7 2.1e-13 50.0 0.1 4.6 3 1 1 4 4 4 2 Importin-beta N-terminal domain HEAT_EZ PF13513.6 KOH00060.1 - 7.6e-16 58.2 0.0 0.0012 19.3 0.0 8.3 8 0 0 8 8 8 2 HEAT-like repeat HEAT PF02985.22 KOH00060.1 - 1e-11 44.0 0.7 0.21 11.9 0.0 8.2 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 KOH00060.1 - 3.6e-09 36.9 0.6 0.054 13.9 0.0 6.0 5 0 0 5 5 5 2 HEAT repeats RIX1 PF08167.12 KOH00060.1 - 1e-05 25.3 0.2 0.049 13.4 0.0 4.7 3 2 1 4 4 4 1 rRNA processing/ribosome biogenesis Vac14_Fab1_bd PF12755.7 KOH00060.1 - 3.4e-05 24.4 1.5 25 5.6 0.1 6.6 5 1 1 7 7 7 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 KOH00060.1 - 0.0001 22.0 0.4 5.3 6.5 0.0 5.0 5 1 1 6 6 6 2 CLASP N terminal Cnd1 PF12717.7 KOH00060.1 - 0.0009 19.3 10.2 1.3 9.1 0.1 5.6 6 1 1 7 7 7 2 non-SMC mitotic condensation complex subunit 1 G-alpha PF00503.20 KOH00060.1 - 0.014 14.6 0.4 0.033 13.4 0.3 1.7 1 1 0 1 1 1 0 G-protein alpha subunit HHV-5_US34A PF17087.5 KOH00060.1 - 0.043 14.0 0.0 0.087 13.0 0.0 1.5 1 0 0 1 1 1 0 Herpesvirus US34A protein family DGF-1_C PF11040.8 KOH00060.1 - 0.083 12.9 0.1 21 5.2 0.0 3.1 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus RTP1_C1 PF10363.9 KOH00060.1 - 0.12 12.6 1.3 2.8 8.1 0.2 3.5 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 PAD_M PF08527.10 KOH00060.1 - 0.15 11.7 0.3 2 8.1 0.0 2.4 2 1 0 2 2 2 0 Protein-arginine deiminase (PAD) middle domain KilA-N PF04383.13 KOH00061.1 - 4.4e-07 29.7 0.9 4.4e-07 29.7 0.9 5.5 5 1 0 5 5 5 1 KilA-N domain Ank_2 PF12796.7 KOH00061.1 - 4.7e-07 30.3 1.2 0.047 14.3 0.0 2.9 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOH00061.1 - 1.1e-06 29.0 2.1 0.068 13.8 0.4 3.5 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KOH00061.1 - 0.00034 20.9 2.2 0.4 11.2 0.2 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 KOH00061.1 - 0.00053 20.2 1.6 0.11 13.2 0.1 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 KOH00061.1 - 0.004 17.4 1.6 0.18 12.1 0.2 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) LSM PF01423.22 KOH00062.1 - 1.9e-17 62.7 0.2 4e-17 61.7 0.2 1.6 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KOH00062.1 - 1.5e-05 25.0 0.3 4.7e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 Ataxin 2 SM domain ALMT PF11744.8 KOH00062.1 - 1 8.1 5.3 1.1 8.0 5.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 KOH00062.1 - 5 5.8 6.9 6.4 5.4 6.9 1.1 1 0 0 1 1 1 0 Presenilin EMP70 PF02990.16 KOH00063.1 - 5.3e-143 477.4 17.9 7.9e-143 476.9 17.9 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 RCR PF12273.8 KOH00063.1 - 0.13 12.9 0.2 0.62 10.7 0.0 2.3 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red PH PF00169.29 KOH00064.1 - 2.4e-18 66.6 0.0 2.4e-18 66.6 0.0 2.5 3 0 0 3 3 3 1 PH domain SH3_1 PF00018.28 KOH00064.1 - 2e-12 46.5 0.2 4.2e-12 45.5 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SAM_2 PF07647.17 KOH00064.1 - 1.7e-11 44.1 0.0 3.5e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 KOH00064.1 - 6.4e-06 25.9 0.1 1.2e-05 25.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_8 PF15409.6 KOH00064.1 - 0.00032 20.9 0.0 0.0081 16.4 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain SAM_1 PF00536.30 KOH00064.1 - 0.0013 19.2 0.1 0.0027 18.1 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_11 PF15413.6 KOH00064.1 - 0.0087 16.5 0.0 0.0087 16.5 0.0 3.3 4 1 0 4 4 4 1 Pleckstrin homology domain SH3_2 PF07653.17 KOH00064.1 - 0.02 14.6 0.0 0.044 13.5 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain zf-C3HC4 PF00097.25 KOH00066.1 - 4.1e-07 29.8 14.4 8e-07 28.8 14.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOH00066.1 - 7.1e-06 25.8 9.1 7.1e-06 25.8 9.1 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOH00066.1 - 9.5e-06 25.4 12.0 1.9e-05 24.4 12.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOH00066.1 - 5.9e-05 23.3 14.8 0.00011 22.4 14.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 KOH00066.1 - 0.0001 22.2 12.2 0.00023 21.1 12.2 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOH00066.1 - 0.00083 19.3 13.5 0.0028 17.6 13.6 1.8 1 1 1 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KOH00066.1 - 0.63 9.9 14.0 3.3 7.7 14.5 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KOH00066.1 - 0.66 10.2 16.6 0.49 10.6 14.9 1.7 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Ribosomal_L14 PF00238.19 KOH00067.1 - 2e-33 115.1 0.0 2.4e-33 114.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e SH3_1 PF00018.28 KOH00068.1 - 4.9e-12 45.2 0.2 9.4e-12 44.4 0.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOH00068.1 - 1.9e-10 40.4 0.1 3.1e-10 39.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOH00068.1 - 1.6e-07 30.9 0.0 3e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain TctB PF07331.11 KOH00068.1 - 0.0031 17.8 3.0 0.0046 17.2 3.0 1.2 1 0 0 1 1 1 1 Tripartite tricarboxylate transporter TctB family Aa_trans PF01490.18 KOH00069.1 - 2.5e-119 398.6 27.9 3e-119 398.4 27.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KOH00069.1 - 3e-09 36.4 15.9 3e-09 36.4 15.9 1.7 1 1 1 2 2 2 1 Tryptophan/tyrosine permease family Motile_Sperm PF00635.26 KOH00070.1 - 6.8e-27 93.5 0.4 1.7e-26 92.2 0.0 1.8 2 0 0 2 2 2 1 MSP (Major sperm protein) domain TMEM131_like PF12371.8 KOH00070.1 - 7.1e-05 23.0 0.1 0.00016 21.9 0.1 1.5 1 0 0 1 1 1 1 Transmembrane protein 131-like Big_2 PF02368.18 KOH00070.1 - 0.012 15.5 0.9 0.58 10.1 0.6 2.5 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 2) DUF5001 PF16392.5 KOH00070.1 - 0.045 13.7 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 Ig-like domain ArfGap PF01412.18 KOH00071.1 - 1.7e-33 115.2 0.4 1.7e-33 115.2 0.4 2.4 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf Pkinase PF00069.25 KOH00072.1 - 6.5e-18 65.0 0.4 1e-16 61.1 0.0 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00072.1 - 4.4e-07 29.4 0.0 7.8e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOH00072.1 - 6.4e-06 25.2 2.2 7.2e-06 25.0 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase WD40 PF00400.32 KOH00073.1 - 0.055 14.4 3.6 4.7 8.2 0.0 4.3 5 0 0 5 5 5 0 WD domain, G-beta repeat HECT PF00632.25 KOH00074.1 - 1.1e-94 317.4 0.0 1.4e-94 317.1 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 KOH00074.1 - 4.2e-34 116.3 22.8 4.2e-12 45.9 1.3 4.1 4 0 0 4 4 4 3 WW domain C2 PF00168.30 KOH00074.1 - 1.5e-19 70.2 0.1 4e-19 68.8 0.1 1.8 1 0 0 1 1 1 1 C2 domain CDC27 PF09507.10 KOH00074.1 - 0.096 12.1 4.3 0.15 11.4 4.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Ribosomal_S8e PF01201.22 KOH00075.1 - 8e-43 145.9 3.3 1.2e-42 145.4 3.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S8e Sas10_Utp3 PF04000.15 KOH00076.1 - 2.5e-12 47.2 0.6 2.5e-12 47.2 0.6 2.2 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Vfa1 PF08432.10 KOH00077.1 - 2.4e-38 132.3 4.0 2.9e-38 132.0 4.0 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 BCIP PF13862.6 KOH00077.1 - 0.0038 17.0 1.7 0.0038 17.0 1.7 1.7 2 0 0 2 2 2 1 p21-C-terminal region-binding protein DUF5611 PF18446.1 KOH00077.1 - 0.035 15.0 0.5 0.035 15.0 0.5 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5611) V_ATPase_I PF01496.19 KOH00077.1 - 0.17 9.8 2.7 0.19 9.6 2.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pkinase PF00069.25 KOH00078.1 - 1.6e-56 191.6 0.2 2.6e-56 190.9 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00078.1 - 9.1e-26 90.7 0.2 4.6e-25 88.4 0.2 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOH00078.1 - 3.5e-05 23.3 0.0 6.6e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOH00078.1 - 0.00014 20.8 0.0 0.00014 20.8 0.0 1.9 2 1 0 2 2 2 1 Fungal protein kinase zf-C2H2 PF00096.26 KOH00079.1 - 7e-11 42.0 16.4 7.1e-06 26.2 3.4 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOH00079.1 - 7.3e-08 32.6 16.4 0.00013 22.5 2.0 3.1 3 0 0 3 3 2 2 C2H2-type zinc finger zf-met PF12874.7 KOH00079.1 - 1.9e-06 28.1 6.8 0.02 15.3 0.1 2.9 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KOH00079.1 - 4.3e-05 23.7 9.3 0.0018 18.5 0.9 3.2 4 0 0 4 4 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 KOH00079.1 - 0.00037 20.8 19.2 0.0018 18.6 6.8 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 KOH00079.1 - 0.0029 17.6 1.7 0.0029 17.6 1.7 3.1 3 0 0 3 3 3 1 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KOH00079.1 - 0.025 14.3 6.7 0.9 9.4 0.4 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-Di19 PF05605.12 KOH00079.1 - 0.032 14.5 7.2 0.053 13.8 7.2 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.11 KOH00079.1 - 0.091 12.6 1.1 0.2 11.5 1.1 1.6 1 0 0 1 1 1 0 GAGA factor zf-C2H2_2 PF12756.7 KOH00079.1 - 0.36 11.2 8.1 6.1 7.2 0.9 2.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 KOH00079.1 - 0.57 10.3 11.5 1 9.4 7.5 2.8 2 1 1 3 3 3 0 BED zinc finger Elf1 PF05129.13 KOH00079.1 - 0.87 9.7 9.3 1.6 8.8 2.7 2.5 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-C2HE PF16278.5 KOH00079.1 - 3.2 8.3 10.0 97 3.5 10.0 2.7 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.6 KOH00079.1 - 5.2 7.1 8.9 9.8 6.2 2.8 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Ribosomal_S26e PF01283.19 KOH00080.1 - 2.9e-51 172.4 9.7 3.4e-51 172.2 9.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e Kelch_6 PF13964.6 KOH00081.1 - 9.9e-12 44.7 1.9 6.4e-05 23.1 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 KOH00081.1 - 1.6e-11 44.0 0.8 0.0044 17.0 0.0 5.1 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KOH00081.1 - 1.4e-09 37.4 0.0 0.0036 16.8 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 KOH00081.1 - 2.4e-05 24.1 0.8 0.46 10.5 0.0 3.2 2 1 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 KOH00081.1 - 0.00022 21.4 0.5 0.15 12.4 0.0 4.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 KOH00081.1 - 0.00024 21.0 0.0 0.00096 19.1 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Acid_PPase PF12689.7 KOH00083.1 - 9.4e-43 146.0 0.0 1.1e-42 145.8 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase GDI PF00996.18 KOH00084.1 - 5e-232 770.0 0.2 5.7e-232 769.8 0.2 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 KOH00084.1 - 0.0018 18.5 0.0 0.0036 17.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain zf-C2H2_10 PF16588.5 KOH00085.1 - 7.2e-15 54.4 4.5 1.1e-14 53.8 4.5 1.3 1 0 0 1 1 1 1 C2H2 zinc-finger ParcG PF10274.9 KOH00085.1 - 0.064 13.4 0.2 0.077 13.1 0.2 1.1 1 0 0 1 1 1 0 Parkin co-regulated protein RPAP2_Rtr1 PF04181.13 KOH00088.1 - 1.7e-17 63.5 0.3 3.4e-17 62.5 0.3 1.5 1 0 0 1 1 1 1 Rtr1/RPAP2 family DUF747 PF05346.11 KOH00089.1 - 1.5e-81 274.3 19.3 2.4e-81 273.7 19.3 1.3 1 0 0 1 1 1 1 Eukaryotic membrane protein family COX15-CtaA PF02628.15 KOH00090.1 - 1.1e-114 382.9 6.6 1.4e-114 382.6 6.6 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Cytochrom_B561 PF03188.16 KOH00090.1 - 0.12 12.5 5.3 0.059 13.5 2.3 2.0 2 0 0 2 2 2 0 Eukaryotic cytochrome b561 HhH-GPD PF00730.25 KOH00091.1 - 2.2e-12 47.4 0.0 4.3e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Asp_protease PF09668.10 KOH00092.1 - 1.5e-49 166.9 0.1 2.4e-49 166.3 0.1 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KOH00092.1 - 2.1e-18 66.7 0.1 4e-18 65.8 0.1 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease UBA PF00627.31 KOH00092.1 - 3.8e-09 36.3 0.0 9.8e-09 34.9 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Asp_protease_2 PF13650.6 KOH00092.1 - 4.3e-09 36.9 0.4 1.1e-08 35.6 0.2 1.9 2 0 0 2 2 2 1 Aspartyl protease RVP PF00077.20 KOH00092.1 - 0.00015 22.0 0.2 0.00034 20.9 0.2 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 KOH00092.1 - 0.001 18.8 0.0 0.0022 17.8 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease UN_NPL4 PF11543.8 KOH00092.1 - 0.0036 17.7 0.0 0.014 15.9 0.0 1.9 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 UBA_3 PF09288.10 KOH00092.1 - 0.08 12.8 0.4 0.3 10.9 0.0 2.2 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain UCH PF00443.29 KOH00093.1 - 1e-58 198.9 1.2 1.4e-58 198.4 1.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOH00093.1 - 1.8e-22 80.3 2.2 1e-21 77.9 2.2 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 KOH00093.1 - 2e-08 34.7 0.0 3.8e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain HAUS4 PF14735.6 KOH00093.1 - 0.14 11.9 2.0 0.11 12.2 0.2 1.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 4 FTR1 PF03239.14 KOH00094.1 - 2.9e-104 348.5 7.3 3.6e-104 348.2 7.3 1.1 1 0 0 1 1 1 1 Iron permease FTR1 family DUF839 PF05787.13 KOH00094.1 - 0.01 15.1 0.2 0.014 14.6 0.2 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF839) DUF1542 PF07564.11 KOH00094.1 - 1 9.5 5.5 1.6 8.9 5.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) VIT1 PF01988.19 KOH00094.1 - 5 6.9 7.2 3.3 7.5 1.7 2.3 2 0 0 2 2 2 0 VIT family LSM PF01423.22 KOH00095.1 - 1.5e-19 69.4 0.4 2e-19 69.0 0.4 1.2 1 0 0 1 1 1 1 LSM domain BPL_C PF02237.17 KOH00095.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Cohesin_load PF10345.9 KOH00096.1 - 2.5e-98 330.1 5.6 3.3e-98 329.7 5.6 1.0 1 0 0 1 1 1 1 Cohesin loading factor TBP PF00352.21 KOH00097.1 - 6.7e-68 224.7 0.4 1.1e-32 111.8 0.0 2.5 3 0 0 3 3 3 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 KOH00097.1 - 1.8e-05 24.8 0.1 0.25 11.5 0.0 2.8 2 1 1 3 3 3 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 KOH00097.1 - 0.034 14.0 0.2 0.26 11.1 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) CALCOCO1 PF07888.11 KOH00098.1 - 0.00012 21.1 6.0 0.00012 21.1 6.0 2.2 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like ADIP PF11559.8 KOH00098.1 - 0.0048 17.0 8.1 0.0048 17.0 8.1 2.7 2 1 0 2 2 2 1 Afadin- and alpha -actinin-Binding NYD-SP28_assoc PF14775.6 KOH00098.1 - 0.041 14.0 0.9 0.041 14.0 0.9 3.1 3 1 1 4 4 4 0 Sperm tail C-terminal domain TPR_MLP1_2 PF07926.12 KOH00098.1 - 0.37 10.8 23.1 2.1 8.4 0.8 3.6 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Nup54 PF13874.6 KOH00098.1 - 1.8 8.7 8.9 0.074 13.2 2.5 2.0 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Prominin PF05478.11 KOH00098.1 - 2.2 6.1 7.5 2.7 5.9 6.9 1.4 1 1 0 1 1 1 0 Prominin Val_tRNA-synt_C PF10458.9 KOH00098.1 - 3.1 8.1 8.4 17 5.8 0.6 2.9 2 1 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm HIP1_clath_bdg PF16515.5 KOH00098.1 - 5.1 7.8 19.0 1.5 9.4 4.3 3.4 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4140 PF13600.6 KOH00098.1 - 5.2 7.6 7.0 54 4.3 1.8 3.2 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) UCH PF00443.29 KOH00100.1 - 5.7e-51 173.5 3.5 5.7e-51 173.5 3.5 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Aminotran_1_2 PF00155.21 KOH00101.1 - 3.5e-22 79.1 0.0 4.2e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 KOH00101.1 - 0.00012 21.0 0.0 0.00014 20.8 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase PET122 PF05476.11 KOH00102.1 - 1.9e-44 151.9 0.0 2.4e-44 151.6 0.0 1.0 1 0 0 1 1 1 1 PET122 60KD_IMP PF02096.20 KOH00103.1 - 1.7e-21 76.9 0.3 1.7e-21 76.9 0.3 2.1 2 0 0 2 2 2 1 60Kd inner membrane protein RhoGAP PF00620.27 KOH00104.1 - 2.1e-40 138.0 0.3 3e-39 134.3 0.0 2.9 2 0 0 2 2 2 1 RhoGAP domain RasGEF_N PF00618.20 KOH00104.1 - 3.3e-20 72.3 0.7 4.7e-19 68.6 0.7 3.2 1 0 0 1 1 1 1 RasGEF N-terminal motif RasGEF PF00617.19 KOH00104.1 - 2.1e-11 44.3 6.3 1.4e-07 31.9 0.3 3.6 3 0 0 3 3 3 2 RasGEF domain PH PF00169.29 KOH00104.1 - 8e-07 29.5 1.1 3.5e-06 27.5 0.1 2.7 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 KOH00104.1 - 0.0099 16.2 0.0 0.074 13.4 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain UPF0160 PF03690.13 KOH00105.1 - 7e-129 430.0 0.0 7.9e-129 429.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Sec34 PF04136.15 KOH00106.1 - 8.5e-45 152.3 4.9 8.5e-45 152.3 4.9 3.3 2 1 0 2 2 2 1 Sec34-like family UPF0184 PF03670.13 KOH00106.1 - 0.0085 16.5 0.2 0.087 13.2 0.1 2.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0184) Med2 PF11214.8 KOH00106.1 - 0.043 14.0 1.2 0.41 10.8 1.2 2.8 1 1 0 1 1 1 0 Mediator complex subunit 2 DUF5446 PF17522.2 KOH00106.1 - 0.092 12.9 0.0 0.31 11.3 0.0 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5446) CENP-Q PF13094.6 KOH00106.1 - 0.1 12.8 0.6 0.75 10.0 0.0 2.5 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Erf4 PF10256.9 KOH00106.1 - 1.1 9.3 4.6 4.3 7.5 0.1 3.7 4 0 0 4 4 4 0 Golgin subfamily A member 7/ERF4 family CBFD_NFYB_HMF PF00808.23 KOH00108.1 - 5.6e-11 42.6 0.1 8.6e-11 42.0 0.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SPT2 PF08243.11 KOH00109.1 - 2e-29 102.4 32.3 2e-29 102.4 32.3 1.9 2 0 0 2 2 2 1 SPT2 chromatin protein Rad4 PF03835.15 KOH00110.1 - 5.3e-37 126.7 1.8 1.2e-36 125.6 1.8 1.6 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 KOH00110.1 - 1.5e-23 83.0 0.1 2.9e-23 82.1 0.1 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 KOH00110.1 - 3.2e-15 55.7 0.0 9.3e-15 54.2 0.0 1.8 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.19 KOH00110.1 - 4.1e-06 27.2 0.0 1.1e-05 25.8 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily BHD_2 PF10404.9 KOH00110.1 - 1.3e-05 26.0 3.5 2e-05 25.4 0.1 3.1 3 0 0 3 3 3 1 Rad4 beta-hairpin domain 2 SNF2_N PF00176.23 KOH00111.1 - 3.5e-61 206.8 0.0 6.1e-61 206.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Cdh1_DBD_1 PF18196.1 KOH00111.1 - 6.3e-42 142.7 2.2 6.3e-42 142.7 2.2 3.3 3 0 0 3 3 3 1 Chromodomain helicase DNA-binding domain 1 DUF4208 PF13907.6 KOH00111.1 - 1.1e-29 102.6 1.8 1.1e-29 102.6 1.8 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4208) Chromo PF00385.24 KOH00111.1 - 2.8e-23 81.6 2.0 1.1e-14 54.0 0.1 3.3 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 KOH00111.1 - 2.9e-20 72.6 0.0 1.2e-19 70.7 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOH00111.1 - 9.9e-09 35.4 0.0 4.9e-08 33.2 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KOH00111.1 - 5.3e-08 32.4 0.1 2.1e-07 30.4 0.1 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-binding PF00249.31 KOH00111.1 - 3.1e-05 24.1 0.0 0.00012 22.2 0.0 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOH00111.1 - 9.4e-05 22.6 0.0 0.00041 20.6 0.0 2.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain ERCC3_RAD25_C PF16203.5 KOH00111.1 - 0.00068 18.9 0.0 0.0016 17.7 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SLIDE PF09111.10 KOH00111.1 - 0.002 18.2 0.0 0.002 18.2 0.0 3.1 3 1 0 3 3 2 1 SLIDE CHDCT2 PF08074.11 KOH00111.1 - 0.014 15.5 0.0 0.086 13.0 0.0 2.4 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain RRM_1 PF00076.22 KOH00112.1 - 2.1e-85 280.6 5.3 9.6e-22 76.6 0.2 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 KOH00112.1 - 1.5e-18 66.7 3.2 2.5e-18 66.0 0.2 2.6 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 KOH00112.1 - 3.8e-11 42.7 0.0 0.036 13.6 0.0 4.2 1 1 3 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOH00112.1 - 1.8e-06 27.9 1.0 0.044 13.9 0.0 4.9 4 3 0 4 4 4 1 RNA recognition motif RRM_3 PF08777.11 KOH00112.1 - 1e-05 25.5 4.6 0.18 11.8 1.3 4.7 3 1 1 4 4 4 1 RNA binding motif RRM_occluded PF16842.5 KOH00112.1 - 2.9e-05 23.8 0.0 0.1 12.5 0.0 4.1 4 0 0 4 4 4 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 KOH00112.1 - 0.0005 20.0 0.8 9.7 6.3 0.0 3.7 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif YflT PF11181.8 KOH00112.1 - 0.0021 18.5 11.4 0.022 15.3 1.0 3.9 3 1 1 4 4 4 1 Heat induced stress protein YflT OB_RNB PF08206.11 KOH00112.1 - 0.0042 16.7 2.4 4.4 7.1 0.1 3.5 3 0 0 3 3 3 1 Ribonuclease B OB domain DUF4523 PF15023.6 KOH00112.1 - 0.0054 16.6 0.0 3.3 7.5 0.0 3.4 2 1 1 3 3 3 1 Protein of unknown function (DUF4523) PhoLip_ATPase_C PF16212.5 KOH00113.1 - 2.7e-77 259.9 27.8 2.7e-77 259.9 27.8 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KOH00113.1 - 4.8e-19 67.8 0.5 4.8e-19 67.8 0.5 2.6 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 KOH00113.1 - 9e-13 48.1 0.0 4.9e-12 45.8 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOH00113.1 - 7.9e-11 42.6 0.1 2.3e-06 28.1 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KOH00113.1 - 0.00087 18.9 3.1 0.0017 17.9 0.1 2.6 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KOH00113.1 - 0.0042 16.9 0.2 0.0099 15.6 0.2 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PolyA_pol PF01743.20 KOH00115.1 - 9.9e-34 116.5 0.0 1.8e-33 115.7 0.0 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 KOH00115.1 - 3.2e-05 23.6 0.0 8e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 KOH00115.1 - 0.0055 16.7 0.0 0.014 15.4 0.0 1.6 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative Ldi PF18566.1 KOH00115.1 - 0.19 11.2 0.0 0.69 9.3 0.0 1.7 2 0 0 2 2 2 0 Linalool dehydratase/isomerase Mistic PF11458.8 KOH00115.1 - 0.34 10.9 2.7 0.39 10.7 0.2 2.4 2 0 0 2 2 2 0 Membrane-integrating protein Mistic JmjC PF02373.22 KOH00116.1 - 7.1e-42 142.4 0.8 7.1e-42 142.4 0.8 2.7 2 0 0 2 2 2 1 JmjC domain, hydroxylase JmjN PF02375.17 KOH00116.1 - 4e-14 52.3 3.1 8.2e-14 51.3 1.7 2.3 2 0 0 2 2 2 1 jmjN domain zf-H2C2_2 PF13465.6 KOH00116.1 - 1.9e-07 31.2 13.5 1.6e-06 28.3 6.7 2.9 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 KOH00116.1 - 5.3e-06 26.6 16.0 0.0084 16.5 2.6 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOH00116.1 - 6.6e-05 23.4 15.6 0.076 13.9 5.7 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KOH00116.1 - 0.0018 18.3 3.3 0.0057 16.7 3.3 1.9 1 0 0 1 1 1 1 Zinc ribbon domain zf-C2H2_6 PF13912.6 KOH00116.1 - 0.011 15.7 13.8 0.017 15.1 5.3 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger zf-MYST PF17772.1 KOH00116.1 - 0.06 13.0 0.1 0.18 11.5 0.1 1.8 1 0 0 1 1 1 0 MYST family zinc finger domain DZR PF12773.7 KOH00116.1 - 0.13 12.3 0.6 0.39 10.8 0.6 1.8 1 0 0 1 1 1 0 Double zinc ribbon SUIM_assoc PF16619.5 KOH00116.1 - 0.22 11.6 14.2 0.1 12.7 11.3 2.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 zf_UBZ PF18439.1 KOH00116.1 - 0.43 10.2 3.5 8.9 6.0 0.3 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF3533 PF12051.8 KOH00116.1 - 0.45 9.4 2.3 0.76 8.6 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) zf-C2H2_11 PF16622.5 KOH00116.1 - 6.9 6.5 8.9 0.91 9.3 3.9 2.1 2 0 0 2 2 2 0 zinc-finger C2H2-type ADK PF00406.22 KOH00117.1 - 1.4e-41 142.1 0.0 1.7e-41 141.8 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOH00117.1 - 4.7e-19 69.2 0.0 7.1e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 KOH00117.1 - 7e-13 48.3 0.0 1.6e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 KOH00117.1 - 0.00083 19.5 0.0 0.0021 18.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOH00117.1 - 0.0055 17.2 0.0 0.02 15.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain DUF3420 PF11900.8 KOH00117.1 - 0.029 14.5 0.0 0.085 13.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3420) ABC_tran PF00005.27 KOH00117.1 - 0.1 13.1 0.0 0.2 12.2 0.0 1.3 1 1 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.12 KOH00117.1 - 0.1 11.8 0.1 0.19 11.0 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin DEAD_2 PF06733.15 KOH00118.1 - 2.3e-58 196.7 3.5 4.9e-58 195.6 3.5 1.6 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.6 KOH00118.1 - 1.5e-44 152.2 0.1 5.5e-44 150.3 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain HBB PF06777.11 KOH00118.1 - 4.4e-44 150.5 2.9 2.6e-40 138.2 0.9 2.5 2 0 0 2 2 2 2 Helical and beta-bridge domain ResIII PF04851.15 KOH00118.1 - 0.00073 19.6 0.1 0.02 14.9 0.1 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOH00118.1 - 0.014 15.2 0.0 3.4 7.4 0.0 2.7 2 0 0 2 2 2 0 DEAD/DEAH box helicase Sec63 PF02889.16 KOH00119.1 - 1.2e-141 470.3 5.9 2e-76 256.5 0.1 2.5 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 KOH00119.1 - 5.9e-47 159.7 0.0 7.9e-29 100.7 0.0 3.7 4 0 0 4 4 4 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 KOH00119.1 - 1.3e-20 73.6 1.4 4.1e-20 72.0 0.4 2.6 2 0 0 2 2 2 1 N-terminal helicase PWI domain ResIII PF04851.15 KOH00119.1 - 4.6e-19 69.1 0.0 1.5e-13 51.1 0.0 2.9 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOH00119.1 - 2.9e-09 37.3 0.2 1.5e-07 31.7 0.0 3.3 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOH00119.1 - 1.7e-05 25.1 0.8 0.053 13.8 0.0 3.4 3 0 0 3 3 3 2 AAA domain PhoH PF02562.16 KOH00119.1 - 0.0012 18.3 0.0 0.43 10.0 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_16 PF13191.6 KOH00119.1 - 0.045 14.1 0.0 4.2 7.7 0.0 2.9 2 0 0 2 2 2 0 AAA ATPase domain Helicase_RecD PF05127.14 KOH00119.1 - 0.066 13.1 0.0 4.3 7.2 0.0 2.9 3 0 0 3 3 3 0 Helicase AAA PF00004.29 KOH00119.1 - 0.083 13.3 0.2 7.6 7.0 0.2 3.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 KOH00120.1 - 9.4e-68 227.8 3.8 6.4e-67 225.1 0.2 3.1 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_16 PF13191.6 KOH00120.1 - 0.0002 21.8 0.0 0.00045 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 KOH00120.1 - 0.0012 18.8 0.0 0.0045 16.9 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 KOH00120.1 - 0.0015 18.2 0.0 0.0046 16.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 KOH00120.1 - 0.0045 17.4 0.0 0.014 15.7 0.0 1.9 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 KOH00120.1 - 0.01 15.2 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOH00120.1 - 0.019 15.0 0.0 0.039 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 KOH00120.1 - 0.025 15.0 0.0 0.084 13.3 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Methyltransf_31 PF13847.6 KOH00121.1 - 3.4e-13 49.6 0.0 5.1e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOH00121.1 - 6.9e-10 39.5 0.0 1.1e-09 38.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOH00121.1 - 1.1e-09 38.9 0.0 1.9e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOH00121.1 - 1.1e-08 35.6 0.0 2.1e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOH00121.1 - 1.6e-05 24.8 0.0 3e-05 23.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOH00121.1 - 0.00098 18.5 0.0 0.0015 17.9 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 KOH00121.1 - 0.0011 18.3 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 KOH00121.1 - 0.0095 15.4 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.6 KOH00121.1 - 0.067 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KOH00121.1 - 0.2 11.2 0.0 0.34 10.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain AAA_12 PF13087.6 KOH00122.1 - 5.5e-60 202.4 0.1 5.5e-60 202.4 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 KOH00122.1 - 1.4e-32 113.6 0.5 3e-17 63.3 0.1 4.6 2 2 2 4 4 4 2 AAA domain AAA_19 PF13245.6 KOH00122.1 - 2.4e-12 47.4 0.2 1.8e-11 44.5 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 KOH00122.1 - 1.3e-10 41.3 0.0 1.6e-09 37.8 0.0 2.3 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KOH00122.1 - 2.2e-05 24.3 7.4 0.079 12.7 0.0 4.8 5 0 0 5 5 5 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 KOH00122.1 - 0.0054 16.5 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain PhoH PF02562.16 KOH00122.1 - 0.0075 15.7 0.0 0.024 14.1 0.0 1.8 1 0 0 1 1 1 1 PhoH-like protein AAA PF00004.29 KOH00122.1 - 0.011 16.2 0.1 0.05 14.0 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOH00122.1 - 0.026 14.9 0.0 0.062 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 KOH00122.1 - 0.12 12.6 0.0 0.42 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain 14-3-3 PF00244.20 KOH00123.1 - 8.8e-106 352.4 6.1 1.1e-105 352.1 6.1 1.1 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.11 KOH00123.1 - 0.008 16.2 0.6 0.023 14.7 0.6 1.7 1 0 0 1 1 1 1 Flagellar protein FlaF FRG PF08867.11 KOH00123.1 - 0.5 11.3 0.2 0.5 11.3 0.2 2.2 3 1 1 4 4 4 0 FRG domain MCM6_C PF18263.1 KOH00123.1 - 3.6 7.9 11.6 1.2 9.4 0.8 3.1 3 0 0 3 3 3 0 MCM6 C-terminal winged-helix domain E1_dh PF00676.20 KOH00124.1 - 3.9e-122 406.9 0.0 4.8e-122 406.6 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 KOH00124.1 - 0.0051 16.0 0.0 0.0083 15.4 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase KRTAP7 PF15034.6 KOH00124.1 - 0.043 14.8 4.2 0.34 11.9 0.1 3.1 3 2 0 3 3 3 0 KRTAP type 7 family Rad51 PF08423.11 KOH00125.1 - 1e-100 336.3 0.0 1.1e-100 336.1 0.0 1.0 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 KOH00125.1 - 1.4e-06 28.1 0.0 1.9e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 KOH00125.1 - 0.00014 21.4 0.0 0.00018 21.0 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_24 PF13479.6 KOH00125.1 - 0.21 11.3 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF2205 PF10224.9 KOH00127.1 - 4.4e-08 33.0 3.0 5.8e-08 32.6 3.0 1.2 1 0 0 1 1 1 1 Short coiled-coil protein RBD-FIP PF09457.10 KOH00127.1 - 0.25 11.3 4.3 0.25 11.3 0.7 2.1 1 1 1 2 2 2 0 FIP domain DivIC PF04977.15 KOH00127.1 - 1.1 9.1 4.5 3.9 7.3 0.2 2.1 1 1 1 2 2 2 0 Septum formation initiator Phage_holin_5_2 PF16079.5 KOH00128.1 - 0.041 14.2 0.2 0.11 12.8 0.0 1.7 2 0 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V Synaptonemal_3 PF15191.6 KOH00128.1 - 0.091 12.5 0.1 0.53 10.1 0.0 2.0 2 0 0 2 2 2 0 Synaptonemal complex central element protein 3 5-FTHF_cyc-lig PF01812.20 KOH00129.1 - 1.1e-57 195.0 0.0 1.4e-57 194.6 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Fe-ADH PF00465.19 KOH00130.1 - 1.4e-119 399.2 1.1 1.7e-119 398.9 1.1 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 KOH00130.1 - 6.7e-21 75.1 2.2 2e-18 67.0 2.2 2.2 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase GTP-bdg_N PF13167.6 KOH00130.1 - 0.15 12.8 0.0 1.6 9.5 0.0 2.3 2 0 0 2 2 2 0 GTP-binding GTPase N-terminal Mannosyl_trans3 PF11051.8 KOH00131.1 - 8.2e-70 235.3 0.2 1.2e-69 234.7 0.2 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative DUF5461 PF17545.2 KOH00131.1 - 0.038 14.3 0.1 0.1 12.9 0.1 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5461) Zn_clus PF00172.18 KOH00132.1 - 1.1e-07 31.9 13.9 2.5e-07 30.7 13.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 KOH00132.1 - 0.026 13.6 9.1 0.0077 15.3 6.2 1.6 2 0 0 2 2 2 0 Fungal specific transcription factor domain Sugar_tr PF00083.24 KOH00133.1 - 1.9e-100 336.9 19.7 2.2e-100 336.6 19.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOH00133.1 - 2.6e-11 43.1 27.9 3.5e-08 32.8 8.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KOH00133.1 - 3.5e-06 25.8 0.4 3.5e-06 25.8 0.4 2.3 2 0 0 2 2 2 1 MFS/sugar transport protein Alpha-amylase PF00128.24 KOH00134.1 - 4.9e-125 417.6 0.1 8.1e-125 416.8 0.1 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 KOH00134.1 - 0.0071 16.4 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 KOH00134.1 - 0.034 13.2 0.1 0.069 12.2 0.0 1.4 2 0 0 2 2 2 0 Glycogen debranching enzyme, glucanotransferase domain Sugar_tr PF00083.24 KOH00135.1 - 3.3e-168 560.2 35.1 3.8e-168 560.0 35.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOH00135.1 - 5.3e-25 88.1 35.9 1.7e-22 79.8 21.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1772 PF08592.11 KOH00135.1 - 0.22 11.8 10.3 0.7 10.2 0.3 3.8 3 2 1 4 4 4 0 Domain of unknown function (DUF1772) Alpha-amylase PF00128.24 KOH00136.1 - 2.2e-128 428.5 0.5 3.7e-128 427.8 0.5 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 KOH00136.1 - 1.4e-05 25.1 0.0 3.3e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 KOH00136.1 - 0.0062 15.7 0.1 0.019 14.1 0.0 1.7 2 0 0 2 2 2 1 Glycogen debranching enzyme, glucanotransferase domain IL17R_fnIII_D2 PF16578.5 KOH00136.1 - 0.071 13.6 0.0 8.9 6.9 0.0 2.9 2 0 0 2 2 2 0 Interleukin 17 receptor D MFS_1 PF07690.16 KOH00137.1 - 1.7e-17 63.4 46.3 1.4e-16 60.4 39.3 3.5 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 KOH00137.1 - 1.6e-07 30.2 19.9 2.1e-07 29.8 19.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) SRP1_TIP1 PF00660.17 KOH00138.1 - 8.9e-27 93.1 0.0 1.2e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family MFS_1 PF07690.16 KOH00139.1 - 4.4e-17 62.0 45.5 5.2e-16 58.5 42.9 3.2 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 KOH00139.1 - 1.8e-07 30.0 19.9 2.3e-07 29.6 19.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) SRP1_TIP1 PF00660.17 KOH00140.1 - 8.9e-27 93.1 0.0 1.2e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family Sugar_tr PF00083.24 KOH00141.1 - 3.6e-87 293.1 20.4 4.4e-87 292.8 20.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOH00141.1 - 2.5e-32 112.2 25.4 2.5e-32 112.2 25.4 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 KOH00141.1 - 0.001 17.6 10.4 0.0023 16.5 3.4 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) RhoGAP PF00620.27 KOH00143.1 - 9e-36 123.0 1.8 1.8e-35 122.0 0.2 2.4 3 0 0 3 3 3 1 RhoGAP domain LIM PF00412.22 KOH00143.1 - 1.3e-32 111.8 52.4 4.8e-15 55.5 7.0 4.5 4 0 0 4 4 4 4 LIM domain Gin PF10764.9 KOH00143.1 - 0.53 10.3 11.4 0.43 10.6 0.2 4.0 4 0 0 4 4 4 0 Inhibitor of sigma-G Gin PriA_CRR PF18319.1 KOH00143.1 - 2.9 8.0 14.4 0.79 9.8 0.2 3.9 4 0 0 4 4 4 0 PriA DNA helicase Cys-rich region (CRR) domain Mut7-C PF01927.16 KOH00143.1 - 5.5 7.1 13.9 0.048 13.8 2.2 3.1 3 0 0 3 3 3 0 Mut7-C RNAse domain SID PF11778.8 KOH00144.1 - 1.6e-40 138.3 2.5 1.6e-40 138.3 2.5 2.5 2 0 0 2 2 2 1 Septation initiation HTH_1 PF00126.27 KOH00144.1 - 0.031 14.2 0.6 0.074 13.0 0.6 1.7 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family Cep57_CLD_2 PF14197.6 KOH00144.1 - 0.042 13.9 1.1 0.042 13.9 1.1 5.4 4 1 1 5 5 5 0 Centrosome localisation domain of PPC89 DUF4200 PF13863.6 KOH00144.1 - 4.1 7.8 49.6 0.22 11.9 21.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Amidohydro_1 PF01979.20 KOH00145.1 - 7.7e-101 337.8 0.0 9e-101 337.6 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KOH00145.1 - 4.8e-11 42.8 0.1 9.6e-09 35.2 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Hydrolase_6 PF13344.6 KOH00147.1 - 1.6e-27 95.5 0.0 5.7e-27 93.8 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOH00147.1 - 2.5e-15 57.4 0.0 3.3e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOH00147.1 - 3.7e-14 52.5 0.0 6.3e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 KOH00147.1 - 5.9e-06 26.5 0.2 0.0009 19.4 0.0 2.5 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hpt PF01627.23 KOH00148.1 - 2e-11 44.0 0.1 3.2e-11 43.3 0.1 1.3 1 0 0 1 1 1 1 Hpt domain RabGAP-TBC PF00566.18 KOH00149.1 - 3.6e-31 108.5 11.0 3.6e-31 108.5 11.0 4.2 3 2 1 4 4 4 2 Rab-GTPase-TBC domain DUF1451 PF07295.11 KOH00149.1 - 0.081 13.0 0.9 0.35 10.9 0.5 2.2 2 0 0 2 2 2 0 Zinc-ribbon containing domain HTH_50 PF18024.1 KOH00149.1 - 0.16 11.6 0.1 0.49 10.0 0.1 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain TSC22 PF01166.18 KOH00149.1 - 3.3 8.1 6.3 25 5.3 0.6 3.4 3 0 0 3 3 3 0 TSC-22/dip/bun family LIM_bind PF01803.16 KOH00150.1 - 1.3e-56 191.8 2.0 1.8e-56 191.4 2.0 1.2 1 0 0 1 1 1 1 LIM-domain binding protein Ost4 PF10215.9 KOH00151.1 - 4.3e-18 64.8 3.5 4.6e-18 64.8 3.5 1.0 1 0 0 1 1 1 1 Oligosaccaryltransferase FUSC_2 PF13515.6 KOH00152.1 - 5.6e-10 39.4 25.1 8e-10 38.9 5.2 2.4 2 0 0 2 2 2 2 Fusaric acid resistance protein-like ArAE_2 PF10334.9 KOH00152.1 - 5.5e-05 23.1 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 ArAE_2_N PF10337.9 KOH00152.1 - 6.9e-05 22.1 20.2 0.00015 20.9 2.3 4.0 3 1 1 4 4 4 2 Putative ER transporter, 6TM, N-terminal ALMT PF11744.8 KOH00152.1 - 0.24 10.2 1.7 0.5 9.2 0.1 2.3 2 1 0 2 2 2 0 Aluminium activated malate transporter CPBP PF02517.16 KOH00152.1 - 0.34 11.3 0.0 0.34 11.3 0.0 2.8 2 0 0 2 2 2 0 CPBP intramembrane metalloprotease FUSC PF04632.12 KOH00152.1 - 0.4 9.2 0.0 0.4 9.2 0.0 2.5 2 1 1 3 3 3 0 Fusaric acid resistance protein family EF-hand_14 PF17959.1 KOH00152.1 - 2 8.8 4.9 2.5 8.5 0.3 2.9 3 0 0 3 3 3 0 EF-hand domain Y_phosphatase PF00102.27 KOH00153.1 - 6.8e-53 179.6 0.4 3.9e-52 177.1 0.4 2.0 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KOH00153.1 - 7.7e-05 22.5 0.0 0.00013 21.8 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KOH00153.1 - 0.00081 19.4 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KOH00153.1 - 0.011 15.8 0.1 0.036 14.2 0.0 1.8 2 0 0 2 2 2 0 Inositol hexakisphosphate Myotub-related PF06602.14 KOH00153.1 - 0.082 11.8 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain HSP70 PF00012.20 KOH00154.1 - 3.9e-220 732.1 9.4 4.4e-220 731.9 9.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOH00154.1 - 1.1e-16 60.6 0.2 1.8e-16 59.9 0.2 1.2 1 0 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.16 KOH00154.1 - 0.0042 16.8 0.0 0.008 15.9 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Zincin_2 PF10103.9 KOH00154.1 - 0.015 14.6 0.0 0.03 13.6 0.0 1.5 1 0 0 1 1 1 0 Zincin-like metallopeptidase Hom_end PF05204.14 KOH00155.1 - 1.3e-45 154.0 0.0 6.9e-39 132.4 0.0 2.5 2 0 0 2 2 2 2 Homing endonuclease Hom_end_hint PF05203.16 KOH00155.1 - 1.9e-44 152.4 0.0 2.3e-44 152.0 0.0 1.1 1 0 0 1 1 1 1 Hom_end-associated Hint LAGLIDADG_3 PF14528.6 KOH00155.1 - 3.2e-08 33.8 0.0 8.3e-06 26.0 0.0 2.6 2 0 0 2 2 2 2 LAGLIDADG-like domain ArfGap PF01412.18 KOH00156.1 - 9e-30 103.2 0.3 2.3e-29 101.8 0.0 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PHA_synth_III_E PF09712.10 KOH00156.1 - 0.042 12.9 3.0 0.063 12.4 3.0 1.2 1 0 0 1 1 1 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) Septin PF00735.18 KOH00157.1 - 7.5e-72 242.0 5.6 1.1e-66 225.1 0.9 2.6 3 0 0 3 3 3 2 Septin AIG1 PF04548.16 KOH00157.1 - 0.011 15.1 1.9 0.015 14.7 0.0 2.1 2 0 0 2 2 2 0 AIG1 family AAA_22 PF13401.6 KOH00157.1 - 0.011 16.0 0.0 0.036 14.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KOH00157.1 - 0.011 15.7 0.0 0.17 11.8 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 KOH00157.1 - 0.012 15.6 0.0 0.012 15.6 0.0 3.5 2 2 0 2 2 1 0 Dynamin family Guanylate_kin PF00625.21 KOH00157.1 - 0.013 15.2 1.0 4.6 6.9 0.0 2.9 2 0 0 2 2 2 0 Guanylate kinase AAA_7 PF12775.7 KOH00157.1 - 0.014 14.9 0.0 0.032 13.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 KOH00157.1 - 0.018 14.8 0.1 0.17 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KOH00157.1 - 0.019 15.1 0.0 0.07 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOH00157.1 - 0.024 15.1 0.9 0.18 12.2 0.0 2.6 3 1 0 3 3 2 0 AAA ATPase domain RNA_helicase PF00910.22 KOH00157.1 - 0.076 13.4 0.0 0.23 11.8 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA PF00004.29 KOH00157.1 - 0.091 13.2 0.3 0.39 11.1 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KOH00157.1 - 0.1 13.2 2.5 0.19 12.3 0.0 2.7 3 1 0 3 3 3 0 AAA domain DUF5395 PF17373.2 KOH00157.1 - 0.26 11.9 1.2 3.3 8.4 0.3 3.1 3 1 1 4 4 3 0 Family of unknown function (DUF5395) Synaptobrevin PF00957.21 KOH00157.1 - 0.31 10.9 4.9 0.58 10.0 3.9 2.1 1 1 0 1 1 1 0 Synaptobrevin PRKG1_interact PF15898.5 KOH00157.1 - 1.1 10.3 17.1 6.1 7.8 4.0 2.9 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain RRM_1 PF00076.22 KOH00158.1 - 7.7e-18 64.1 0.0 3.6e-14 52.3 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUR7 PF06687.12 KOH00160.1 - 9.8e-44 149.5 5.7 1.3e-43 149.1 5.7 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF2207 PF09972.9 KOH00160.1 - 0.33 9.7 5.7 0.047 12.5 1.4 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Fig1 PF12351.8 KOH00160.1 - 0.36 10.7 10.7 0.74 9.7 10.7 1.5 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 CDC13_N PF16853.5 KOH00161.1 - 2e-72 243.1 2.6 4.4e-72 242.0 2.6 1.6 1 0 0 1 1 1 1 Cell division control protein 13 N-terminus Cdc13_OB2 PF18691.1 KOH00161.1 - 1.7e-34 118.2 0.0 4.3e-34 116.9 0.0 1.7 1 0 0 1 1 1 1 Cell division control protein 13, OB2 domain POT1 PF02765.17 KOH00161.1 - 3.6e-20 72.2 0.4 7.4e-20 71.2 0.4 1.5 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 Cdc13_OB4_dimer PF18233.1 KOH00161.1 - 4.4e-11 42.9 0.0 9.9e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 Cdc13 OB4 dimerization domain DUF4110 PF13422.6 KOH00161.1 - 0.029 14.4 0.9 0.72 10.0 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4110) Tyr_Deacylase PF02580.16 KOH00162.1 - 1.1e-49 168.6 0.1 1.3e-49 168.5 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase MARVEL PF01284.23 KOH00163.1 - 1.4e-25 90.0 11.4 2.1e-25 89.4 11.4 1.2 1 0 0 1 1 1 1 Membrane-associating domain BCD PF15461.6 KOH00163.1 - 0.027 14.0 6.5 0.082 12.4 6.5 1.8 1 1 0 1 1 1 0 Beta-carotene 15,15'-dioxygenase Bunya_G2 PF03563.13 KOH00163.1 - 0.027 13.7 1.7 0.05 12.8 1.7 1.4 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 Penaeidin PF05927.11 KOH00163.1 - 0.067 13.9 0.1 0.15 12.8 0.1 1.6 1 0 0 1 1 1 0 Penaeidin UbiA PF01040.18 KOH00163.1 - 0.37 10.0 9.3 0.2 10.9 5.4 2.0 2 0 0 2 2 2 0 UbiA prenyltransferase family Dexa_ind PF15198.6 KOH00163.1 - 0.42 10.7 3.3 0.98 9.6 3.3 1.5 1 0 0 1 1 1 0 Dexamethasone-induced DUF3488 PF11992.8 KOH00163.1 - 0.46 9.4 3.3 0.47 9.3 1.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3488) KASH PF10541.9 KOH00163.1 - 1 9.7 4.8 1.1 9.6 0.1 2.9 2 1 1 3 3 3 0 Nuclear envelope localisation domain DUF1772 PF08592.11 KOH00163.1 - 1.2 9.4 6.2 13 6.1 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) DUF4870 PF09685.10 KOH00163.1 - 3.4 7.8 9.2 0.61 10.2 4.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4870) DHHC PF01529.20 KOH00163.1 - 5.7 7.1 9.7 16 5.6 0.5 2.3 1 1 1 2 2 2 0 DHHC palmitoyltransferase Tim17 PF02466.19 KOH00164.1 - 7.2e-36 122.9 6.6 1e-35 122.5 6.6 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family CbtA PF09490.10 KOH00164.1 - 0.074 12.8 2.0 5.8 6.6 0.0 2.2 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) JAB PF01398.21 KOH00165.1 - 9.9e-30 102.9 0.1 3.2e-29 101.3 0.1 1.9 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 KOH00165.1 - 0.0088 15.8 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain EF1_GNE PF00736.19 KOH00165.1 - 0.13 12.4 0.1 0.35 11.1 0.1 1.7 1 0 0 1 1 1 0 EF-1 guanine nucleotide exchange domain ELFV_dehydrog PF00208.21 KOH00166.1 - 2.7e-65 220.5 0.0 1.1e-64 218.5 0.0 1.9 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 KOH00166.1 - 4.1e-18 64.4 0.1 1.4e-12 46.1 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 KOH00166.1 - 0.00098 19.0 0.0 0.0098 15.8 0.0 2.3 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain DUF2564 PF10819.8 KOH00166.1 - 0.041 14.3 0.0 0.097 13.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2564) DUF5097 PF17020.5 KOH00166.1 - 0.49 10.7 6.2 0.38 11.1 3.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5097) Pkinase PF00069.25 KOH00167.1 - 7.6e-45 153.3 0.0 1.2e-44 152.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00167.1 - 1.2e-21 77.2 0.0 2.2e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOH00167.1 - 0.0029 17.0 0.9 0.019 14.3 0.9 2.2 1 1 0 1 1 1 1 Kinase-like RRM_1 PF00076.22 KOH00168.1 - 0.00097 18.9 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOH00168.1 - 0.083 13.0 0.0 0.28 11.3 0.0 1.8 1 1 0 1 1 1 0 RNA recognition motif SHR3_chaperone PF08229.11 KOH00169.1 - 3.5e-74 247.9 0.4 4.4e-74 247.5 0.4 1.1 1 0 0 1 1 1 1 ER membrane protein SH3 DUF2681 PF10883.8 KOH00169.1 - 0.14 12.6 4.4 0.26 11.7 4.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Romo1 PF10247.9 KOH00170.1 - 0.023 15.0 0.1 0.05 14.0 0.1 1.5 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 Amnionless PF14828.6 KOH00170.1 - 0.035 13.0 0.0 0.054 12.3 0.0 1.2 1 0 0 1 1 1 0 Amnionless EphA2_TM PF14575.6 KOH00170.1 - 0.061 14.2 0.0 0.11 13.4 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Mucin15 PF15672.5 KOH00170.1 - 0.12 11.8 24.0 0.42 10.1 24.0 1.8 1 1 0 1 1 1 0 Cell-membrane associated Mucin15 DUF2613 PF11021.8 KOH00170.1 - 0.26 11.4 2.0 0.68 10.1 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) DPM2 PF07297.12 KOH00170.1 - 0.94 9.8 3.6 0.49 10.7 1.0 1.7 2 0 0 2 2 2 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PTP_tm PF18861.1 KOH00170.1 - 4.4 7.3 10.2 0.3 11.0 1.0 2.6 3 0 0 3 3 3 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J AA_permease_2 PF13520.6 KOH00171.1 - 5.7e-70 236.3 41.6 6.9e-70 236.0 41.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOH00171.1 - 3.6e-19 68.7 37.4 7e-19 67.8 37.4 1.4 1 1 0 1 1 1 1 Amino acid permease DUF1129 PF06570.11 KOH00171.1 - 4 6.9 6.5 0.36 10.3 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) Torus PF16131.5 KOH00172.1 - 3.8e-32 111.2 0.0 8e-32 110.2 0.0 1.5 1 0 0 1 1 1 1 Torus domain RRM_1 PF00076.22 KOH00172.1 - 1.1e-06 28.4 0.0 2.4e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 KOH00172.1 - 0.01 15.8 5.2 0.023 14.8 5.2 1.6 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH_4 PF18044.1 KOH00172.1 - 0.03 14.1 7.7 0.057 13.2 7.7 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger RRM_3 PF08777.11 KOH00172.1 - 0.042 13.9 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 RNA binding motif RRM_occluded PF16842.5 KOH00172.1 - 0.081 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF4523 PF15023.6 KOH00172.1 - 0.11 12.4 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) Ribosomal_L7Ae PF01248.26 KOH00173.1 - 6.9e-28 96.2 0.8 1.2e-27 95.5 0.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Citrate_synt PF00285.21 KOH00173.1 - 0.095 11.8 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Citrate synthase, C-terminal domain GLE1 PF07817.13 KOH00174.1 - 3e-87 292.0 0.1 3e-87 292.0 0.1 1.9 2 1 0 2 2 2 1 GLE1-like protein WDCP PF15390.6 KOH00174.1 - 0.02 13.3 20.6 0.029 12.8 20.6 1.3 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family RR_TM4-6 PF06459.12 KOH00174.1 - 3 7.6 24.2 5.1 6.9 24.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Asp-B-Hydro_N PF05279.11 KOH00174.1 - 3 7.8 24.9 5 7.1 24.9 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Neur_chan_memb PF02932.16 KOH00174.1 - 4.8 7.2 16.3 8.7 6.3 16.3 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 KOH00174.1 - 8.1 5.1 19.9 12 4.5 19.9 1.2 1 0 0 1 1 1 0 Presenilin Bud13 PF09736.9 KOH00174.1 - 8.6 6.8 30.9 19 5.6 30.9 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Na_Ca_ex PF01699.24 KOH00175.1 - 3.4e-58 195.9 37.8 1.3e-36 125.8 8.7 2.7 3 0 0 3 3 3 2 Sodium/calcium exchanger protein YwiC PF14256.6 KOH00175.1 - 0.0033 17.7 1.0 0.0082 16.5 0.0 2.1 2 0 0 2 2 2 1 YwiC-like protein WBP-1 PF11669.8 KOH00175.1 - 0.0038 17.8 0.1 0.56 10.9 0.1 2.8 2 0 0 2 2 2 1 WW domain-binding protein 1 Mucin PF01456.17 KOH00175.1 - 0.094 12.7 0.1 0.25 11.3 0.0 1.6 2 0 0 2 2 2 0 Mucin-like glycoprotein Porphobil_deam PF01379.20 KOH00176.1 - 1.1e-73 247.1 0.0 1.4e-73 246.7 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 KOH00176.1 - 5.1e-23 81.2 2.3 8.3e-23 80.6 2.3 1.3 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Reticulon PF02453.17 KOH00177.1 - 1.4e-25 90.1 0.1 2.5e-25 89.3 0.1 1.4 1 0 0 1 1 1 1 Reticulon SCFA_trans PF02667.14 KOH00177.1 - 0.023 13.7 0.2 0.035 13.1 0.2 1.2 1 0 0 1 1 1 0 Short chain fatty acid transporter ECM1 PF05782.11 KOH00177.1 - 0.32 9.9 2.8 0.19 10.6 0.9 1.5 1 1 1 2 2 2 0 Extracellular matrix protein 1 (ECM1) Sel1 PF08238.12 KOH00178.1 - 9.2e-32 108.8 22.1 4.1e-06 27.3 0.1 7.9 7 2 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.6 KOH00178.1 - 0.58 10.9 8.2 45 5.0 0.0 5.9 6 2 0 6 6 6 0 Tetratricopeptide repeat Ribosomal_L10 PF00466.20 KOH00179.1 - 1.6e-09 37.8 0.0 2.7e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Methyltransf_4 PF02390.17 KOH00180.1 - 5.9e-63 211.4 0.1 8.2e-63 211.0 0.1 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 KOH00180.1 - 0.00028 21.5 0.0 0.00092 19.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KOH00180.1 - 0.0011 18.5 0.0 0.0043 16.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 KOH00180.1 - 0.012 15.4 0.0 0.028 14.2 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 KOH00180.1 - 0.014 16.1 0.0 0.041 14.6 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.18 KOH00180.1 - 0.025 13.9 0.0 0.073 12.4 0.0 1.7 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DNA_binding_1 PF01035.20 KOH00181.1 - 4.1e-30 103.7 0.0 5.8e-30 103.3 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N PF02870.15 KOH00181.1 - 4.9e-10 40.1 0.1 7.9e-10 39.4 0.1 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain Thioredoxin_11 PF18078.1 KOH00181.1 - 0.056 13.6 0.1 0.085 13.0 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin-like SNTX domain Sugar_tr PF00083.24 KOH00182.1 - 4.3e-41 141.2 21.9 5.4e-41 140.9 21.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOH00182.1 - 5.3e-12 45.3 20.2 5.3e-12 45.3 20.2 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Gcd10p PF04189.13 KOH00182.1 - 0.094 11.8 0.1 0.16 11.0 0.1 1.3 1 0 0 1 1 1 0 Gcd10p family Abhydrolase_9_N PF15420.6 KOH00182.1 - 5.3 7.0 7.8 17 5.3 0.2 3.0 3 1 0 3 3 3 0 Alpha/beta-hydrolase family N-terminus Mito_carr PF00153.27 KOH00183.1 - 6.8e-33 112.5 0.1 1.4e-14 53.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein NHR2 PF08788.11 KOH00184.1 - 0.098 12.4 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 NHR2 domain like ANAPC1 PF12859.7 KOH00184.1 - 1.3 9.6 8.4 5.7 7.5 0.0 3.1 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 1 DUF3972 PF13118.6 KOH00184.1 - 3.1 8.2 15.8 0.046 14.2 4.8 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3972) Sec31 PF11549.8 KOH00185.1 - 2e-25 88.4 3.1 2e-25 88.4 3.1 2.5 2 0 0 2 2 2 1 Protein transport protein SEC31 WD40 PF00400.32 KOH00185.1 - 4.8e-11 43.0 17.1 0.00057 20.6 0.1 7.2 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00185.1 - 5.2e-09 36.3 4.9 0.36 11.1 0.0 4.9 2 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain SRA1 PF07304.11 KOH00185.1 - 6.4e-08 32.5 0.0 6.4e-08 32.5 0.0 2.7 2 1 0 2 2 2 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.7 KOH00185.1 - 1.1e-05 25.2 0.4 3.3e-05 23.7 0.3 1.8 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 eIF2A PF08662.11 KOH00185.1 - 2.1e-05 24.5 0.5 0.00055 19.9 0.1 2.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Prp18 PF02840.15 KOH00185.1 - 0.0061 16.6 3.8 0.0078 16.3 0.3 2.9 3 1 0 3 3 3 1 Prp18 domain Sugar_tr PF00083.24 KOH00186.1 - 1.2e-133 446.3 29.8 1.5e-133 446.0 29.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOH00186.1 - 1e-18 67.4 39.4 5.7e-15 55.1 12.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex14_N PF04695.13 KOH00186.1 - 5.1 7.7 7.0 0.31 11.7 0.2 2.4 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Arf PF00025.21 KOH00188.1 - 5.4e-78 260.4 0.0 6.2e-78 260.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KOH00188.1 - 2.5e-14 53.5 0.1 3.4e-14 53.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOH00188.1 - 4.9e-14 52.2 0.0 5.7e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KOH00188.1 - 3.4e-13 49.4 0.0 4.1e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KOH00188.1 - 3.8e-12 46.0 0.6 3.6e-08 33.0 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KOH00188.1 - 9e-10 38.3 0.0 1.1e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOH00188.1 - 2.4e-05 24.4 0.0 3.7e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.22 KOH00188.1 - 0.0082 15.8 0.2 0.015 14.9 0.2 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain cobW PF02492.19 KOH00188.1 - 0.018 14.6 0.1 5.5 6.5 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 KOH00188.1 - 0.035 14.0 0.1 4.9 7.0 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 KOH00188.1 - 0.039 14.1 0.7 0.1 12.7 0.7 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOH00188.1 - 0.044 14.3 0.1 0.079 13.5 0.1 1.5 1 1 0 1 1 1 0 ABC transporter GTP_EFTU PF00009.27 KOH00188.1 - 0.05 13.1 0.1 0.17 11.4 0.0 1.6 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain 6PF2K PF01591.18 KOH00188.1 - 0.057 12.7 0.1 0.077 12.3 0.1 1.4 1 1 0 1 1 1 0 6-phosphofructo-2-kinase NACHT PF05729.12 KOH00188.1 - 0.1 12.5 0.4 9.6 6.1 0.0 2.1 2 0 0 2 2 2 0 NACHT domain Thymidylate_kin PF02223.17 KOH00188.1 - 0.21 11.2 0.9 0.97 9.1 0.3 1.9 2 0 0 2 2 2 0 Thymidylate kinase Ribosomal_L29 PF00831.23 KOH00189.1 - 2.3e-15 56.3 1.6 2.3e-15 56.3 1.6 2.2 2 0 0 2 2 2 1 Ribosomal L29 protein FAM167 PF11652.8 KOH00189.1 - 0.046 14.2 1.3 0.076 13.5 1.4 1.7 1 1 0 1 1 1 0 FAM167 Hydantoinase_A PF01968.18 KOH00189.1 - 0.17 11.1 0.3 0.24 10.6 0.3 1.1 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase MRP-L47 PF06984.13 KOH00189.1 - 0.39 10.8 3.2 0.38 10.9 0.5 2.3 2 2 0 2 2 2 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ufd2P_core PF10408.9 KOH00190.1 - 9.4e-199 662.1 4.6 1.4e-198 661.5 4.6 1.2 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 KOH00190.1 - 4.7e-27 94.0 2.0 1.5e-26 92.4 2.0 1.9 1 0 0 1 1 1 1 U-box domain R3H PF01424.22 KOH00191.1 - 1.8e-09 37.4 0.1 3.5e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 R3H domain MAP7 PF05672.11 KOH00191.1 - 5.8 6.6 13.7 0.42 10.3 8.8 1.6 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Metallophos PF00149.28 KOH00192.1 - 4e-21 76.5 0.4 7.1e-21 75.6 0.1 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase gpW PF02831.15 KOH00192.1 - 0.031 14.2 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 gpW WTX PF09422.10 KOH00192.1 - 0.059 12.4 0.3 0.071 12.2 0.3 1.1 1 0 0 1 1 1 0 WTX protein SUIM_assoc PF16619.5 KOH00193.1 - 0.003 17.6 1.5 0.011 15.8 1.5 2.0 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Cas9_Topo PF17894.1 KOH00193.1 - 0.072 13.2 0.2 1.1 9.3 0.0 2.7 3 0 0 3 3 3 0 Topo homolgy domain in CRISPR-associated endonuclease Cas9 ATP-synt_ab PF00006.25 KOH00194.1 - 2.1e-117 390.3 0.0 3.1e-117 389.7 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 KOH00194.1 - 5.6e-46 155.3 0.0 1e-45 154.5 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 KOH00194.1 - 7.4e-17 61.6 1.7 1.6e-16 60.5 1.7 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_14 PF13173.6 KOH00194.1 - 0.091 12.8 0.0 0.35 10.9 0.0 2.1 1 0 0 1 1 1 0 AAA domain Mit_KHE1 PF10173.9 KOH00195.1 - 7.7e-54 182.7 3.4 1e-53 182.3 3.4 1.2 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related HMGL-like PF00682.19 KOH00196.1 - 7.2e-86 288.0 0.1 1.2e-85 287.3 0.1 1.4 1 0 0 1 1 1 1 HMGL-like SidE PF12252.8 KOH00196.1 - 0.038 11.5 0.1 0.053 11.1 0.1 1.1 1 0 0 1 1 1 0 Dot/Icm substrate protein Trp_syntA PF00290.20 KOH00196.1 - 0.061 12.2 0.0 7.5 5.3 0.0 2.4 2 0 0 2 2 2 0 Tryptophan synthase alpha chain IATP PF04568.12 KOH00197.1 - 1.2e-16 60.9 0.3 1.4e-16 60.7 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Fib_alpha PF08702.10 KOH00197.1 - 0.0051 17.0 0.6 0.0056 16.9 0.6 1.1 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family TRAF_BIRC3_bd PF16673.5 KOH00197.1 - 0.031 14.1 2.9 0.051 13.4 2.7 1.5 1 1 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain DivIC PF04977.15 KOH00197.1 - 0.043 13.6 3.3 0.06 13.1 3.3 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF5339 PF17274.2 KOH00197.1 - 0.055 14.3 0.4 0.067 14.1 0.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5339) DUF4140 PF13600.6 KOH00197.1 - 0.12 12.8 2.5 0.12 12.8 2.5 1.3 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) XhlA PF10779.9 KOH00197.1 - 0.74 10.1 3.9 1 9.6 3.9 1.2 1 0 0 1 1 1 0 Haemolysin XhlA CitMHS PF03600.16 KOH00198.1 - 0.033 13.4 1.0 0.048 12.9 0.1 1.7 2 0 0 2 2 2 0 Citrate transporter Cyclin_N PF00134.23 KOH00199.1 - 5.7e-17 61.7 0.0 8.9e-17 61.0 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 KOH00199.1 - 0.00045 20.6 0.0 0.00076 19.9 0.0 1.4 1 0 0 1 1 1 1 Cyclin FAD-oxidase_C PF02913.19 KOH00200.1 - 3.3e-65 220.2 0.0 4.3e-65 219.8 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KOH00200.1 - 1.2e-33 115.8 0.2 2.6e-33 114.7 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain UPF0029 PF01205.19 KOH00201.1 - 2.1e-32 111.6 1.4 5.8e-32 110.2 1.4 1.6 1 1 0 1 1 1 1 Uncharacterized protein family UPF0029 zf-CCHC PF00098.23 KOH00203.1 - 2.6e-11 43.1 44.0 4.2e-05 23.4 4.9 5.4 5 1 0 5 5 5 3 Zinc knuckle zf-C2H2_10 PF16588.5 KOH00203.1 - 0.0002 21.0 2.1 0.0002 21.0 2.1 5.2 4 1 1 5 5 5 1 C2H2 zinc-finger zf-CCHC_2 PF13696.6 KOH00203.1 - 0.043 13.6 41.7 0.18 11.7 3.3 5.4 5 0 0 5 5 5 0 Zinc knuckle FAD-oxidase_C PF02913.19 KOH00204.1 - 9.7e-60 202.3 0.6 1.4e-59 201.8 0.6 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KOH00204.1 - 8e-36 122.8 0.0 2.4e-35 121.3 0.0 1.9 1 0 0 1 1 1 1 FAD binding domain DUF3602 PF12223.8 KOH00205.1 - 8.4e-19 68.0 19.2 7.3e-10 39.3 2.8 4.3 3 1 1 4 4 4 4 Protein of unknown function (DUF3602) PBP1_TM PF14812.6 KOH00205.1 - 0.0028 18.0 2.3 0.044 14.2 2.0 2.6 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Nucleoporin2 PF04096.14 KOH00205.1 - 0.015 15.4 1.8 5.4 7.1 0.0 3.8 3 1 1 4 4 4 0 Nucleoporin autopeptidase TSGP1 PF07771.11 KOH00205.1 - 6.3 7.0 11.0 0.96 9.6 6.7 1.8 2 0 0 2 2 2 0 Tick salivary peptide group 1 SR-25 PF10500.9 KOH00205.1 - 9.5 5.8 18.9 0.25 10.9 12.1 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein GATase_2 PF00310.21 KOH00206.1 - 2.2e-169 563.6 0.0 3.2e-169 563.1 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 KOH00206.1 - 7.5e-157 522.2 0.0 2.8e-156 520.3 0.0 1.9 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 KOH00206.1 - 6.7e-114 380.1 0.0 2.3e-111 371.7 0.0 2.4 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 KOH00206.1 - 2.8e-71 239.1 2.7 5.3e-71 238.2 2.7 1.5 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.6 KOH00206.1 - 9.9e-23 80.1 0.0 1.8e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 KOH00206.1 - 9e-19 67.8 0.2 1.4e-17 63.8 0.2 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOH00206.1 - 1.2e-08 35.0 0.0 3.6e-08 33.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KOH00206.1 - 2e-08 34.7 1.5 1.1e-06 29.1 0.1 3.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 KOH00206.1 - 2.7e-06 26.9 0.0 1.2e-05 24.8 0.0 2.0 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 KOH00206.1 - 0.00018 20.9 0.3 0.085 12.1 0.1 2.8 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KOH00206.1 - 0.00025 20.5 0.0 0.00043 19.8 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOH00206.1 - 0.00031 19.6 0.1 0.00069 18.4 0.1 1.6 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 KOH00206.1 - 0.00043 19.6 0.2 0.0024 17.2 0.0 2.2 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 KOH00206.1 - 0.0015 17.8 0.1 0.0032 16.8 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain 2-Hacid_dh_C PF02826.19 KOH00206.1 - 0.0017 17.8 0.0 0.025 13.9 0.0 2.6 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 KOH00206.1 - 0.0027 16.8 0.1 0.0049 16.0 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOH00206.1 - 0.01 15.5 0.1 0.028 14.0 0.1 1.8 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 KOH00206.1 - 0.032 13.3 0.4 0.11 11.5 0.0 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_Gly3P_dh_N PF01210.23 KOH00206.1 - 0.044 13.8 0.0 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GATase_6 PF13522.6 KOH00206.1 - 0.067 13.4 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 Glutamine amidotransferase domain Rossmann-like PF10727.9 KOH00206.1 - 0.086 12.7 0.5 0.3 10.9 0.0 2.1 2 0 0 2 2 2 0 Rossmann-like domain NAD_binding_7 PF13241.6 KOH00206.1 - 0.1 13.1 1.3 15 6.1 0.0 3.0 3 0 0 3 3 2 0 Putative NAD(P)-binding FMN_dh PF01070.18 KOH00206.1 - 0.13 11.2 1.9 0.36 9.8 0.8 2.2 3 0 0 3 3 3 0 FMN-dependent dehydrogenase 3HCDH_N PF02737.18 KOH00206.1 - 0.18 11.7 0.0 0.18 11.7 0.0 1.9 2 0 0 2 2 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 KOH00206.1 - 0.21 10.9 0.4 2.5 7.3 0.1 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain AdoHcyase_NAD PF00670.21 KOH00206.1 - 0.41 10.7 3.9 12 5.9 0.1 2.8 1 1 1 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Fungal_trans_2 PF11951.8 KOH00207.1 - 1.7e-63 214.8 2.8 2e-63 214.5 2.8 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOH00207.1 - 8.2e-08 32.3 9.0 1.4e-07 31.5 9.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RAP1 PF07218.11 KOH00208.1 - 0.075 11.3 1.6 0.088 11.1 1.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Attachment_P66 PF11263.8 KOH00208.1 - 0.086 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi attachment protein P66 DUF848 PF05852.11 KOH00208.1 - 0.088 12.9 0.3 0.14 12.3 0.3 1.3 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) LEA_3 PF03242.13 KOH00208.1 - 0.17 12.6 1.5 1.2 10.0 0.0 2.6 1 1 1 2 2 2 0 Late embryogenesis abundant protein ADH_N PF08240.12 KOH00209.1 - 1.1e-25 89.6 2.5 2.3e-25 88.6 2.5 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOH00209.1 - 1.7e-22 79.8 1.4 1.8e-22 79.7 0.3 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOH00209.1 - 0.0012 19.9 0.0 0.0023 19.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 KOH00209.1 - 0.0013 18.1 0.5 0.002 17.4 0.5 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Glu_dehyd_C PF16912.5 KOH00209.1 - 0.0016 17.9 0.0 0.011 15.2 0.0 2.1 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus 2-Hacid_dh_C PF02826.19 KOH00209.1 - 0.0031 16.9 0.1 0.0051 16.2 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 KOH00209.1 - 0.023 14.3 0.4 0.043 13.4 0.4 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 KOH00209.1 - 0.084 13.1 0.1 0.21 11.9 0.1 1.7 1 0 0 1 1 1 0 TrkA-N domain HAV_VP PF12944.7 KOH00209.1 - 0.18 11.7 0.0 0.81 9.6 0.0 2.0 2 0 0 2 2 2 0 Hepatitis A virus viral protein VP zf-RanBP PF00641.18 KOH00210.1 - 3.2e-23 80.7 14.8 5.2e-12 44.9 2.3 3.3 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 KOH00210.1 - 2.6e-08 33.6 0.0 0.00096 18.9 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1480 PF07351.13 KOH00210.1 - 0.15 12.4 0.1 0.41 10.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1480) zinc-ribbon_6 PF10005.9 KOH00210.1 - 0.91 10.2 7.1 7.9 7.2 0.7 2.8 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.7 KOH00210.1 - 0.98 9.5 7.9 5.2 7.2 1.3 2.4 2 0 0 2 2 2 0 Double zinc ribbon AAA_18 PF13238.6 KOH00211.1 - 3.4e-30 105.3 0.0 4.9e-30 104.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KOH00211.1 - 1.4e-06 28.8 0.1 7.2e-06 26.5 0.0 2.2 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.22 KOH00211.1 - 0.00025 21.4 0.3 0.00067 20.0 0.1 1.7 2 0 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 KOH00211.1 - 0.00077 19.7 0.0 0.0015 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOH00211.1 - 0.0011 19.2 0.0 0.0021 18.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOH00211.1 - 0.003 18.0 0.0 0.0039 17.6 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain KTI12 PF08433.10 KOH00211.1 - 0.0035 16.8 0.0 0.029 13.8 0.0 2.0 1 1 0 2 2 2 1 Chromatin associated protein KTI12 Thymidylate_kin PF02223.17 KOH00211.1 - 0.0087 15.7 0.1 3.2 7.4 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase Zeta_toxin PF06414.12 KOH00211.1 - 0.01 15.1 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin dNK PF01712.19 KOH00211.1 - 0.014 15.3 0.0 2.5 7.9 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA PF00004.29 KOH00211.1 - 0.015 15.8 0.0 0.023 15.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 KOH00211.1 - 0.042 13.8 0.0 0.09 12.7 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_5 PF07728.14 KOH00211.1 - 0.053 13.5 0.0 0.086 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ADK PF00406.22 KOH00211.1 - 0.076 13.1 0.1 3 7.9 0.1 2.2 1 1 0 2 2 2 0 Adenylate kinase AAA_33 PF13671.6 KOH00211.1 - 0.086 13.0 0.1 10 6.3 0.1 2.4 1 1 1 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 KOH00211.1 - 0.086 12.6 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 KOH00211.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain NOT2_3_5 PF04153.18 KOH00212.1 - 1.8e-30 105.7 1.3 2.3e-30 105.4 1.3 1.1 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family DNA_ligase_A_M PF01068.21 KOH00213.1 - 7.1e-66 221.7 0.2 1e-65 221.2 0.2 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 KOH00213.1 - 3e-47 161.2 0.1 6.6e-47 160.0 0.1 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 KOH00213.1 - 7.4e-26 90.7 0.0 2.7e-25 88.8 0.0 2.0 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 KOH00213.1 - 8e-06 26.3 0.1 1.3e-05 25.6 0.1 1.4 1 0 0 1 1 1 1 RNA ligase DNA_ligase_OB_2 PF14743.6 KOH00213.1 - 0.007 16.4 0.5 2.4 8.3 0.1 2.7 2 0 0 2 2 2 2 DNA ligase OB-like domain Phasin PF05597.11 KOH00213.1 - 0.018 15.1 0.0 0.052 13.6 0.0 1.7 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) ENTH PF01417.20 KOH00214.1 - 2.7e-41 140.5 0.3 6.2e-41 139.3 0.3 1.6 1 0 0 1 1 1 1 ENTH domain DUF2406 PF10295.9 KOH00214.1 - 0.27 11.9 10.1 3.4 8.4 0.2 3.7 2 2 1 3 3 3 0 Uncharacterised protein (DUF2406) EFTUD2 PF16004.5 KOH00214.1 - 0.51 10.9 0.1 0.38 11.3 6.2 4.3 1 1 2 3 3 3 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Guanylin PF02058.15 KOH00214.1 - 1.9 9.0 6.9 12 6.5 0.9 2.7 1 1 1 2 2 2 0 Guanylin precursor Cytochrom_B559a PF00284.20 KOH00214.1 - 3.9 7.3 7.2 5 7.0 0.1 3.7 4 0 0 4 4 4 0 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit CENP-X PF09415.10 KOH00215.1 - 7.9e-17 61.3 0.1 1e-16 61.0 0.1 1.1 1 0 0 1 1 1 1 CENP-S associating Centromere protein X DEAD PF00270.29 KOH00216.1 - 1.9e-44 151.5 0.1 3.2e-44 150.8 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOH00216.1 - 4.2e-30 104.3 0.6 8e-29 100.2 0.4 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Phage_integrase PF00589.22 KOH00216.1 - 0.1 12.4 0.0 0.3 10.9 0.0 1.7 2 0 0 2 2 2 0 Phage integrase family AAA_30 PF13604.6 KOH00216.1 - 0.15 11.8 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 KOH00217.1 - 1.6e-70 237.5 0.1 2.3e-70 237.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00217.1 - 3.4e-38 131.4 0.0 4.6e-38 131.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOH00217.1 - 4.9e-06 25.7 3.7 1.3e-05 24.3 3.7 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KOH00217.1 - 2.3e-05 23.3 0.0 5.5e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOH00217.1 - 0.00019 20.8 0.0 0.00038 19.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like WD40 PF00400.32 KOH00219.1 - 4.3e-08 33.7 1.8 0.23 12.4 0.0 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00219.1 - 0.00056 20.2 0.0 0.78 10.1 0.0 2.9 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF870 PF05912.11 KOH00219.1 - 0.031 14.3 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 Caenorhabditis elegans protein of unknown function (DUF870) TTR-52 PF01060.23 KOH00219.1 - 0.062 14.0 0.0 0.26 12.0 0.0 2.0 1 1 0 1 1 1 0 Transthyretin-like family Cyclin_N PF00134.23 KOH00220.1 - 7.2e-45 151.8 0.1 1.5e-44 150.8 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOH00220.1 - 5.8e-34 116.7 0.1 1.1e-33 115.8 0.1 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain MutS_V PF00488.21 KOH00221.1 - 1.2e-47 162.4 0.1 2.4e-47 161.4 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KOH00221.1 - 8e-18 65.3 0.9 3.3e-17 63.3 0.4 2.1 2 0 0 2 2 2 1 MutS domain III AAA_29 PF13555.6 KOH00221.1 - 0.074 12.8 0.6 0.28 10.9 0.1 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_14 PF13173.6 KOH00221.1 - 0.78 9.8 5.2 0.45 10.6 0.1 3.1 3 1 1 4 4 4 0 AAA domain Sas10 PF09368.10 KOH00222.1 - 2.4e-28 98.4 11.1 2.4e-28 98.4 11.1 2.1 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 KOH00222.1 - 5.2e-07 30.2 0.1 5.2e-07 30.2 0.1 3.0 4 0 0 4 4 4 1 Sas10/Utp3/C1D family RNA_pol_Rpc4 PF05132.14 KOH00223.1 - 1.8e-24 86.9 2.4 1.8e-24 86.9 2.4 3.8 4 1 0 4 4 4 1 RNA polymerase III RPC4 APG9 PF04109.16 KOH00224.1 - 3.3e-195 649.6 20.3 4e-195 649.4 20.3 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 Nop14 PF04147.12 KOH00225.1 - 7.1e-179 597.0 68.5 2.3e-102 343.8 13.3 2.1 1 1 1 2 2 2 2 Nop14-like family Carbpep_Y_N PF05388.11 KOH00225.1 - 0.31 11.6 6.4 4.4 7.9 0.1 3.6 3 0 0 3 3 3 0 Carboxypeptidase Y pro-peptide PCI PF01399.27 KOH00226.1 - 4.1e-24 85.1 1.9 8.7e-24 84.0 0.2 2.5 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 KOH00226.1 - 7.1e-15 54.8 5.1 7.1e-15 54.8 5.1 2.4 3 0 0 3 3 3 1 26S proteasome regulatory subunit RPN5 C-terminal domain DUF2013 PF09431.10 KOH00227.1 - 6.3e-43 146.3 8.3 6.3e-43 146.3 8.3 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) Coatomer_WDAD PF04053.14 KOH00228.1 - 1.3e-135 452.9 3.6 1.9e-135 452.4 3.6 1.2 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 KOH00228.1 - 5.9e-82 275.6 0.0 8.5e-82 275.0 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 KOH00228.1 - 5.3e-39 131.5 17.3 4.8e-08 33.5 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00228.1 - 1.5e-13 50.9 0.2 7.7e-06 26.1 0.0 6.2 5 2 1 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOH00228.1 - 3.2e-06 27.2 0.7 0.023 14.6 0.1 4.1 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KOH00228.1 - 4.6e-06 25.6 6.4 0.076 11.7 0.1 4.2 1 1 2 4 4 4 3 Nucleoporin Nup120/160 SH3_10 PF17902.1 KOH00228.1 - 0.15 12.2 0.0 0.39 10.8 0.0 1.7 1 0 0 1 1 1 0 SH3 domain TPR_2 PF07719.17 KOH00228.1 - 1.2 9.4 3.3 0.84 9.9 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ApbA_C PF08546.11 KOH00229.1 - 4.7e-28 97.9 0.0 7.4e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 KOH00229.1 - 3.2e-20 72.3 0.0 4.6e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 KOH00229.1 - 0.1 11.9 0.1 0.19 11.0 0.1 1.5 1 0 0 1 1 1 0 ThiF family Cpn60_TCP1 PF00118.24 KOH00230.1 - 2.9e-146 487.9 10.3 3.3e-146 487.8 10.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CDP-OH_P_transf PF01066.21 KOH00231.1 - 1e-15 58.2 1.5 1e-15 58.2 1.5 2.4 3 0 0 3 3 3 1 CDP-alcohol phosphatidyltransferase BPL_N PF09825.9 KOH00232.1 - 1.9e-125 418.9 0.0 2.3e-125 418.6 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 KOH00232.1 - 2.1e-30 105.3 0.5 9.8e-30 103.1 0.5 2.1 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 KOH00232.1 - 7.6e-16 57.7 0.0 1.9e-15 56.5 0.0 1.8 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain RNA_pol_Rpb1_1 PF04997.12 KOH00233.1 - 6.5e-114 380.5 0.0 1.3e-113 379.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 KOH00233.1 - 4.1e-107 357.6 0.1 6e-107 357.0 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 KOH00233.1 - 6.3e-78 260.7 0.0 2.3e-77 258.9 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 KOH00233.1 - 6.1e-62 208.8 0.3 1.1e-61 208.0 0.3 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 KOH00233.1 - 1.5e-46 158.2 0.0 3.8e-46 156.9 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 KOH00233.1 - 1.5e-46 157.7 3.1 3.3e-46 156.6 3.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 KOH00233.1 - 8.2e-35 119.0 0.1 2.3e-34 117.6 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 KOH00233.1 - 5.2e-19 67.5 278.8 0.011 16.1 11.1 14.4 2 1 0 13 13 13 11 RNA polymerase Rpb1 C-terminal repeat Sugar_tr PF00083.24 KOH00234.1 - 4.3e-131 437.9 26.1 5.3e-131 437.6 26.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOH00234.1 - 4.7e-22 78.4 40.9 8.6e-14 51.2 14.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Arf PF00025.21 KOH00235.1 - 1.2e-77 259.4 0.0 1.3e-77 259.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KOH00235.1 - 1.4e-14 54.3 0.1 1.9e-14 53.9 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOH00235.1 - 4.2e-14 52.5 0.0 4.6e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KOH00235.1 - 1.1e-13 51.1 0.0 1.3e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KOH00235.1 - 1.8e-11 43.8 0.9 1.4e-07 31.1 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KOH00235.1 - 1.5e-09 37.5 0.0 1.9e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOH00235.1 - 3.9e-05 23.7 0.0 6.1e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.22 KOH00235.1 - 0.008 15.8 0.2 0.015 14.9 0.2 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain GTP_EFTU PF00009.27 KOH00235.1 - 0.037 13.6 0.1 0.11 12.0 0.0 1.6 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 KOH00235.1 - 0.04 14.4 0.0 0.072 13.6 0.0 1.5 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 KOH00235.1 - 0.045 13.9 0.6 0.11 12.6 0.6 1.9 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 KOH00235.1 - 0.047 13.0 0.2 0.082 12.2 0.2 1.6 1 1 1 2 2 2 0 6-phosphofructo-2-kinase cobW PF02492.19 KOH00235.1 - 0.052 13.1 0.1 7.7 6.1 0.2 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 KOH00235.1 - 0.068 13.1 0.1 9.7 6.1 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 KOH00235.1 - 0.12 12.3 0.4 11 5.9 0.0 2.1 2 0 0 2 2 2 0 NACHT domain Rho_GDI PF02115.17 KOH00236.1 - 4.5e-63 212.5 3.7 5.1e-63 212.4 3.7 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Metallophos PF00149.28 KOH00237.1 - 4e-34 118.9 0.5 7.2e-34 118.1 0.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase MARVEL PF01284.23 KOH00238.1 - 0.097 12.7 3.7 0.2 11.7 3.7 1.5 1 0 0 1 1 1 0 Membrane-associating domain Cullin PF00888.22 KOH00239.1 - 1.7e-149 499.3 15.3 2.3e-149 498.9 15.3 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KOH00239.1 - 4.4e-23 81.1 0.2 4.4e-23 81.1 0.2 2.9 4 0 0 4 4 4 1 Cullin protein neddylation domain HTH_36 PF13730.6 KOH00239.1 - 0.014 15.3 0.1 2.2 8.3 0.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain Penicillinase_R PF03965.16 KOH00239.1 - 0.025 14.9 0.0 0.21 12.0 0.0 2.7 2 0 0 2 2 2 0 Penicillinase repressor HMGL-like PF00682.19 KOH00240.1 - 3.8e-51 174.2 0.2 4.3e-51 174.0 0.2 1.0 1 0 0 1 1 1 1 HMGL-like Oxidored_FMN PF00724.20 KOH00240.1 - 0.11 11.7 0.3 0.46 9.7 0.3 1.9 1 1 0 1 1 1 0 NADH:flavin oxidoreductase / NADH oxidase family IATP PF04568.12 KOH00241.1 - 1.8e-10 41.1 0.4 1.9e-10 41.1 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP DUF4140 PF13600.6 KOH00241.1 - 0.035 14.5 0.1 0.044 14.2 0.1 1.1 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) TRAF_BIRC3_bd PF16673.5 KOH00241.1 - 0.036 13.9 2.2 0.06 13.1 2.2 1.4 1 1 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain DUF2730 PF10805.8 KOH00241.1 - 0.036 14.1 1.1 0.05 13.7 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) XhlA PF10779.9 KOH00241.1 - 0.21 11.8 2.1 0.3 11.3 2.1 1.3 1 0 0 1 1 1 0 Haemolysin XhlA DivIC PF04977.15 KOH00241.1 - 0.76 9.6 5.1 1.1 9.1 5.1 1.3 1 0 0 1 1 1 0 Septum formation initiator Na_Ca_ex PF01699.24 KOH00243.1 - 8e-48 162.2 35.9 8.3e-26 90.7 9.1 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF3169 PF11368.8 KOH00243.1 - 0.23 11.0 11.1 1.1 8.8 2.2 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3169) Cyclin_N PF00134.23 KOH00244.1 - 2.4e-14 53.2 0.0 4.3e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 KOH00244.1 - 3.1e-06 27.6 0.0 3.1e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 Cyclin AAA PF00004.29 KOH00245.1 - 7.8e-98 324.0 0.0 5.8e-48 162.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOH00245.1 - 6.3e-23 80.3 8.5 7.5e-14 51.3 1.8 2.8 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 KOH00245.1 - 6.5e-19 67.9 0.4 1.9e-18 66.4 0.4 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 KOH00245.1 - 4.5e-14 52.5 0.1 1.2e-05 25.1 0.0 3.3 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 KOH00245.1 - 1.2e-13 51.5 0.0 3.3e-07 30.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KOH00245.1 - 6.6e-13 49.4 0.0 8.6e-05 23.0 0.0 4.4 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 KOH00245.1 - 1.4e-11 44.5 0.6 7.9e-06 25.9 0.1 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 KOH00245.1 - 1.5e-11 44.7 0.0 7.8e-06 26.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.17 KOH00245.1 - 3.1e-09 36.5 0.0 9.3e-09 34.9 0.0 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 TIP49 PF06068.13 KOH00245.1 - 3.5e-09 36.3 0.0 0.0016 17.7 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 KOH00245.1 - 9.9e-09 35.6 0.8 0.071 13.4 0.0 4.3 2 2 1 3 3 3 2 AAA domain RNA_helicase PF00910.22 KOH00245.1 - 2.9e-07 30.8 0.0 0.013 15.9 0.0 3.0 3 0 0 3 3 2 2 RNA helicase AAA_14 PF13173.6 KOH00245.1 - 3.2e-07 30.4 0.0 0.026 14.6 0.0 3.2 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.21 KOH00245.1 - 5.2e-07 29.2 0.5 0.037 13.4 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Vps4_C PF09336.10 KOH00245.1 - 7.7e-07 29.0 0.4 5.8e-05 23.0 0.0 3.0 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.17 KOH00245.1 - 1e-06 28.6 0.1 0.032 14.0 0.0 2.9 3 0 0 3 3 2 2 IstB-like ATP binding protein ATPase PF06745.13 KOH00245.1 - 1.6e-06 27.6 0.9 0.38 10.1 0.0 3.6 2 1 0 3 3 3 2 KaiC AAA_18 PF13238.6 KOH00245.1 - 5.7e-06 26.9 0.0 0.21 12.1 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 KOH00245.1 - 6e-06 26.1 0.1 0.089 12.5 0.0 3.0 3 1 0 3 3 2 2 AAA domain AAA_7 PF12775.7 KOH00245.1 - 7.9e-06 25.5 0.1 0.071 12.6 0.0 2.8 2 1 0 2 2 2 2 P-loop containing dynein motor region ABC_tran PF00005.27 KOH00245.1 - 8.8e-06 26.3 0.0 0.057 13.9 0.0 4.1 3 1 0 3 3 3 1 ABC transporter Sigma54_activat PF00158.26 KOH00245.1 - 1.8e-05 24.5 0.1 0.21 11.3 0.0 3.4 3 1 0 3 3 2 2 Sigma-54 interaction domain Parvo_NS1 PF01057.17 KOH00245.1 - 3.3e-05 23.1 0.1 0.13 11.3 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 PhoH PF02562.16 KOH00245.1 - 4.5e-05 23.0 0.4 0.19 11.2 0.1 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_28 PF13521.6 KOH00245.1 - 5.5e-05 23.5 0.0 0.57 10.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 KOH00245.1 - 6.3e-05 22.6 6.5 0.37 10.4 0.2 4.2 2 2 2 4 4 4 1 AAA domain Bac_DnaA PF00308.18 KOH00245.1 - 6.3e-05 22.9 0.1 0.19 11.6 0.0 3.2 4 0 0 4 4 3 1 Bacterial dnaA protein AAA_17 PF13207.6 KOH00245.1 - 0.00011 22.7 0.0 0.57 10.6 0.0 3.2 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.13 KOH00245.1 - 0.00015 21.1 0.0 0.15 11.2 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_3 PF07726.11 KOH00245.1 - 0.00017 21.5 0.0 0.76 9.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 KOH00245.1 - 0.00034 20.6 0.0 0.6 10.1 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 KOH00245.1 - 0.00038 20.5 0.0 0.15 12.1 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 KOH00245.1 - 0.00078 18.8 0.8 1.1 8.5 0.0 2.7 3 0 0 3 3 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 KOH00245.1 - 0.0013 18.5 0.4 2.1 8.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 KOH00245.1 - 0.0014 18.6 0.1 2.2 8.1 0.0 3.3 3 0 0 3 3 3 1 NACHT domain AAA_11 PF13086.6 KOH00245.1 - 0.0028 17.5 5.2 0.97 9.2 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOH00245.1 - 0.0033 17.8 0.7 3.6 7.9 0.0 3.2 2 1 0 3 3 2 0 AAA domain ATPase_2 PF01637.18 KOH00245.1 - 0.0093 15.9 3.1 2.8 7.8 0.0 3.9 3 1 0 3 3 2 1 ATPase domain predominantly from Archaea Sigma54_activ_2 PF14532.6 KOH00245.1 - 0.016 15.4 0.0 1.6 8.8 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain IPT PF01745.16 KOH00245.1 - 0.017 14.5 0.1 2.3 7.6 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Zeta_toxin PF06414.12 KOH00245.1 - 0.019 14.3 0.3 7.4 5.8 0.0 3.1 3 0 0 3 3 2 0 Zeta toxin NB-ARC PF00931.22 KOH00245.1 - 0.028 13.6 0.0 5 6.2 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain UFD1 PF03152.14 KOH00245.1 - 0.03 13.8 0.0 0.089 12.3 0.0 1.7 1 1 1 2 2 2 0 Ubiquitin fusion degradation protein UFD1 NTPase_1 PF03266.15 KOH00245.1 - 0.033 14.1 1.4 8.3 6.3 0.0 4.1 4 0 0 4 4 4 0 NTPase Zot PF05707.12 KOH00245.1 - 0.043 13.5 0.0 2.8 7.6 0.0 3.1 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) KAP_NTPase PF07693.14 KOH00245.1 - 0.055 12.7 0.3 2.2 7.4 0.0 2.8 2 2 1 3 3 3 0 KAP family P-loop domain Cytidylate_kin PF02224.18 KOH00245.1 - 0.055 13.2 0.0 8 6.1 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase eIF-1a PF01176.19 KOH00245.1 - 0.056 13.3 0.5 0.48 10.3 0.2 2.5 1 1 1 2 2 2 0 Translation initiation factor 1A / IF-1 AAA_6 PF12774.7 KOH00245.1 - 0.11 11.4 0.3 5.3 5.9 0.0 2.4 3 0 0 3 3 2 0 Hydrolytic ATP binding site of dynein motor region DUF4637 PF15470.6 KOH00245.1 - 1.7 8.4 3.6 3.2 7.4 3.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) HIT PF01230.23 KOH00246.1 - 2.8e-09 37.6 0.2 3.7e-09 37.2 0.2 1.2 1 0 0 1 1 1 1 HIT domain Pmp3 PF01679.17 KOH00247.1 - 2.8e-20 72.2 6.1 4.5e-20 71.6 6.1 1.3 1 0 0 1 1 1 1 Proteolipid membrane potential modulator UCH PF00443.29 KOH00248.1 - 4.8e-46 157.3 2.3 4.8e-46 157.3 2.3 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOH00248.1 - 0.00072 19.2 9.3 0.0076 15.9 9.3 2.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase LRIF1 PF15741.5 KOH00248.1 - 0.039 12.5 1.5 0.078 11.5 1.5 1.4 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 Mso1_Sec1_bdg PF14475.6 KOH00249.1 - 0.025 14.2 0.2 0.063 12.9 0.2 1.6 1 0 0 1 1 1 0 Sec1-binding region of Mso1 Frataxin_Cyay PF01491.16 KOH00250.1 - 2.1e-36 124.3 0.0 2.6e-36 124.0 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain Mito_carr PF00153.27 KOH00251.1 - 3.6e-48 161.4 4.0 1.7e-17 63.1 0.0 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein SH3_1 PF00018.28 KOH00252.1 - 0.00012 21.6 0.0 0.00029 20.4 0.0 1.7 1 0 0 1 1 1 1 SH3 domain Transglut_core PF01841.19 KOH00252.1 - 0.0014 19.1 0.0 0.0031 18.0 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_9 PF14604.6 KOH00252.1 - 0.0019 18.0 0.0 0.0039 17.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOH00252.1 - 0.0024 17.5 0.1 0.0055 16.4 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SCIMP PF15050.6 KOH00252.1 - 5.7 7.4 12.2 3.6 8.0 4.3 2.8 1 1 1 2 2 2 0 SCIMP protein Nup84_Nup100 PF04121.13 KOH00253.1 - 7.2e-187 622.8 18.9 8.6e-187 622.5 18.9 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 TPH PF13868.6 KOH00253.1 - 1 7.8 6.0 1.7 7.1 6.0 1.2 1 0 0 1 1 1 0 Trichohyalin-plectin-homology domain Iwr1 PF08574.10 KOH00254.1 - 3.1e-15 57.0 14.0 3.1e-15 57.0 14.0 3.5 3 0 0 3 3 3 1 Transcription factor Iwr1 Nucleoporin_FG2 PF15967.5 KOH00254.1 - 0.24 9.9 0.1 0.33 9.4 0.1 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region adh_short PF00106.25 KOH00255.1 - 3.4e-42 144.1 0.0 4.6e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOH00255.1 - 4.3e-27 95.2 0.0 6.3e-27 94.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOH00255.1 - 4.7e-11 42.9 0.2 2.7e-10 40.5 0.2 1.9 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 KOH00255.1 - 0.0002 20.9 0.0 0.00036 20.1 0.0 1.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family PAC4 PF16093.5 KOH00255.1 - 0.012 15.8 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 PX PF00787.24 KOH00256.1 - 2.1e-22 79.2 0.1 2.1e-22 79.2 0.1 2.4 3 0 0 3 3 3 1 PX domain Vps5 PF09325.10 KOH00256.1 - 0.0035 16.9 14.5 0.14 11.7 3.2 2.7 2 1 0 2 2 2 2 Vps5 C terminal like HTH_16 PF12645.7 KOH00256.1 - 0.041 13.9 0.8 0.093 12.8 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain DUF4691 PF15762.5 KOH00256.1 - 0.059 13.5 3.3 0.15 12.2 3.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4691) DUF1938 PF09153.10 KOH00256.1 - 0.16 12.1 0.9 0.93 9.6 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1938) Syntaxin-6_N PF09177.11 KOH00256.1 - 6.6 7.4 7.9 83 3.8 0.5 3.7 2 1 0 2 2 2 0 Syntaxin 6, N-terminal SpoU_methylase PF00588.19 KOH00257.1 - 2.6e-25 89.2 0.0 5.6e-25 88.2 0.0 1.6 1 0 0 1 1 1 1 SpoU rRNA Methylase family CLASP_N PF12348.8 KOH00257.1 - 0.064 12.8 0.2 0.49 9.9 0.0 2.4 2 0 0 2 2 2 0 CLASP N terminal RNase_PH PF01138.21 KOH00258.1 - 1.8e-06 28.5 0.1 3.1e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KOH00258.1 - 5.1e-06 26.4 0.0 1e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Spc7 PF08317.11 KOH00259.1 - 0.0069 15.3 2.3 0.0089 14.9 2.3 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Use1 PF09753.9 KOH00259.1 - 0.0095 15.7 0.4 0.025 14.3 0.4 1.7 1 1 0 1 1 1 1 Membrane fusion protein Use1 Cluap1 PF10234.9 KOH00259.1 - 0.066 12.6 0.2 0.066 12.6 0.2 1.5 2 0 0 2 2 2 0 Clusterin-associated protein-1 SGT1 PF07093.11 KOH00259.1 - 0.17 10.3 3.3 0.19 10.1 3.3 1.0 1 0 0 1 1 1 0 SGT1 protein DUF676 PF05057.14 KOH00260.1 - 3.1e-61 206.7 0.1 5.6e-61 205.8 0.1 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 KOH00260.1 - 0.0098 15.8 0.0 0.021 14.7 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.7 KOH00260.1 - 0.056 13.2 0.1 0.16 11.7 0.1 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family Pkinase PF00069.25 KOH00261.1 - 8.9e-61 205.5 0.0 1e-60 205.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00261.1 - 9.3e-24 84.1 0.0 1.8e-23 83.1 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 KOH00261.1 - 8.5e-05 22.6 0.1 0.00012 22.1 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOH00261.1 - 0.0013 18.2 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like TPR_8 PF13181.6 KOH00262.1 - 0.013 15.7 11.8 0.1 12.9 0.9 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF19 PF01579.18 KOH00262.1 - 0.02 14.7 0.9 0.02 14.7 0.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF19) TPR_19 PF14559.6 KOH00262.1 - 0.021 15.3 0.1 7 7.2 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOH00262.1 - 0.025 14.7 8.7 0.075 13.2 0.3 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat CbtA_toxin PF06755.12 KOH00262.1 - 0.028 14.4 0.0 0.054 13.5 0.0 1.5 1 0 0 1 1 1 0 CbtA_toxin of type IV toxin-antitoxin system ANAPC3 PF12895.7 KOH00262.1 - 0.043 14.0 4.8 0.99 9.7 0.3 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KOH00262.1 - 0.081 13.2 1.5 3.1 8.1 0.0 3.4 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOH00262.1 - 0.097 12.5 6.9 0.13 12.2 0.9 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Homeodomain PF00046.29 KOH00263.1 - 1.3e-17 63.4 0.5 2.7e-17 62.3 0.5 1.6 1 0 0 1 1 1 1 Homeodomain TFIIA PF03153.13 KOH00263.1 - 0.068 13.2 36.4 0.089 12.8 18.6 2.8 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 KOH00263.1 - 9.6 7.2 20.7 4.6 8.3 0.4 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Nse4_C PF08743.10 KOH00264.1 - 1.1e-29 102.5 0.8 1.1e-29 102.5 0.8 2.5 2 0 0 2 2 2 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 KOH00264.1 - 1.3e-14 54.0 1.7 3.4e-14 52.7 1.7 1.8 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE DUF2497 PF10691.9 KOH00264.1 - 0.042 14.3 0.2 0.84 10.1 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2497) Peptidase_M22 PF00814.25 KOH00265.1 - 2.4e-74 250.5 0.0 2.8e-74 250.2 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family BcrAD_BadFG PF01869.20 KOH00265.1 - 0.079 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family hnRNP_Q_AcD PF18360.1 KOH00265.1 - 0.12 12.3 0.2 4.3 7.4 0.0 2.4 2 0 0 2 2 2 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain UDPGP PF01704.18 KOH00266.1 - 6.7e-46 156.8 0.0 9.5e-46 156.3 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 KOH00266.1 - 0.1 12.9 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain DNA_pol_B PF00136.21 KOH00267.1 - 3.1e-144 481.1 0.3 4.3e-144 480.6 0.3 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 KOH00267.1 - 4.2e-92 308.9 0.2 8.9e-92 307.8 0.2 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 KOH00267.1 - 1.1e-16 61.0 6.7 2.3e-16 60.0 6.7 1.5 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 KOH00267.1 - 3.7e-05 22.8 0.2 0.00078 18.4 0.0 2.4 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 KOH00267.1 - 0.0019 17.9 0.0 0.0049 16.6 0.0 1.7 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB Pkinase PF00069.25 KOH00268.1 - 1.5e-70 237.6 0.0 2.1e-70 237.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00268.1 - 3.2e-36 124.9 0.0 4.6e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 KOH00268.1 - 1.1e-17 64.2 1.7 1.5e-17 63.7 0.6 1.9 2 0 0 2 2 2 1 FHA domain Pkinase_fungal PF17667.1 KOH00268.1 - 4.4e-06 25.7 0.1 7.7e-06 24.9 0.1 1.5 1 1 0 1 1 1 1 Fungal protein kinase Yop-YscD_cpl PF16697.5 KOH00268.1 - 1.9e-05 24.9 0.0 5.7e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Kdo PF06293.14 KOH00268.1 - 0.00074 18.9 0.3 0.0012 18.2 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOH00268.1 - 0.00098 18.5 3.4 0.93 8.7 0.7 3.3 2 1 1 3 3 3 2 Kinase-like YrbL-PhoP_reg PF10707.9 KOH00268.1 - 0.059 12.9 1.4 0.17 11.4 1.4 1.7 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 KOH00268.1 - 0.15 11.6 1.8 1.6 8.3 0.0 2.3 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 ArsA_ATPase PF02374.15 KOH00269.1 - 5.4e-120 400.2 0.0 6.2e-120 400.0 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 KOH00269.1 - 1e-09 38.6 0.4 9.4e-09 35.4 0.0 2.5 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 KOH00269.1 - 1.6e-08 34.7 0.0 3.9e-08 33.4 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 KOH00269.1 - 0.00095 18.7 0.8 0.0062 16.0 0.3 2.3 2 1 1 3 3 3 1 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 KOH00269.1 - 0.002 17.6 0.0 0.0037 16.7 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 KOH00269.1 - 0.018 14.7 0.0 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 KOH00269.1 - 0.032 13.8 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KOH00269.1 - 0.041 13.6 0.1 0.43 10.3 0.0 2.5 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 KOH00269.1 - 0.068 13.1 0.2 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.16 KOH00269.1 - 0.12 11.8 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein PolyA_pol PF01743.20 KOH00270.1 - 0.025 15.0 3.1 0.025 15.0 3.1 2.8 2 1 1 3 3 3 0 Poly A polymerase head domain Baculo_PEP_C PF04513.12 KOH00270.1 - 0.1 12.6 5.2 0.18 11.8 5.2 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lectin_N PF03954.14 KOH00270.1 - 0.31 10.8 6.0 0.73 9.6 6.0 1.6 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain zf-met PF12874.7 KOH00271.1 - 2.5e-05 24.5 1.0 5.8e-05 23.3 1.0 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KOH00271.1 - 3.5e-05 24.0 0.9 7.4e-05 22.9 0.9 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KOH00271.1 - 0.063 14.2 0.5 0.17 12.8 0.5 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-DBF PF07535.12 KOH00271.1 - 0.063 13.4 1.5 0.14 12.3 0.9 1.9 2 0 0 2 2 2 0 DBF zinc finger FTA4 PF13093.6 KOH00271.1 - 0.065 13.1 2.1 0.15 11.9 2.1 1.7 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 SNRNP27 PF08648.12 KOH00271.1 - 0.11 12.6 0.4 0.11 12.6 0.4 2.3 2 0 0 2 2 2 0 U4/U6.U5 small nuclear ribonucleoproteins zf-C2H2 PF00096.26 KOH00271.1 - 0.13 12.8 1.6 0.25 11.9 1.6 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type RPN6_N PF18055.1 KOH00272.1 - 6.4e-36 123.3 1.0 6.4e-36 123.3 1.0 2.8 3 1 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 KOH00272.1 - 1.6e-18 67.1 2.2 2.3e-18 66.7 0.1 2.3 3 0 0 3 3 3 1 PCI domain RPN6_C_helix PF18503.1 KOH00272.1 - 1.1e-12 47.5 1.4 2.3e-12 46.4 0.2 2.2 2 0 0 2 2 2 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_16 PF13432.6 KOH00272.1 - 0.00039 21.0 0.4 0.51 11.0 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.6 KOH00272.1 - 0.00051 19.3 2.6 0.00051 19.3 2.6 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOH00272.1 - 0.0023 18.2 5.7 0.02 15.2 0.3 3.8 5 0 0 5 5 4 1 Tetratricopeptide repeat DDRGK PF09756.9 KOH00272.1 - 0.017 14.7 0.2 0.017 14.7 0.2 2.0 2 1 1 3 3 3 0 DDRGK domain TPR_19 PF14559.6 KOH00272.1 - 0.091 13.3 2.9 37 4.9 0.2 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF4606 PF15379.6 KOH00272.1 - 0.1 12.9 1.3 0.25 11.6 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4606) TPR_2 PF07719.17 KOH00272.1 - 0.98 9.7 12.1 4 7.8 0.3 5.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOH00272.1 - 2.1 9.1 5.7 14 6.6 0.2 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat PMT PF02366.18 KOH00273.1 - 6.6e-91 304.2 21.3 6.6e-91 304.2 21.3 2.1 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 KOH00273.1 - 2.2e-63 213.5 17.7 2.2e-63 213.5 17.7 2.4 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 KOH00273.1 - 4.8e-51 173.3 0.3 4.8e-51 173.3 0.3 1.7 2 0 0 2 2 2 1 MIR domain PMT PF02366.18 KOH00274.1 - 5.9e-75 252.0 18.0 5.9e-75 252.0 18.0 2.3 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.19 KOH00274.1 - 1.1e-49 168.8 0.0 1.7e-49 168.2 0.0 1.2 1 0 0 1 1 1 1 MIR domain PMT_4TMC PF16192.5 KOH00274.1 - 5.1e-49 166.6 20.1 5.1e-49 166.6 20.1 2.1 2 1 1 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase SRP14 PF02290.15 KOH00275.1 - 8.8e-25 86.9 0.1 2.1e-24 85.7 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle 14kD protein UBX PF00789.20 KOH00276.1 - 3.6e-21 75.1 0.0 7e-21 74.2 0.0 1.5 1 0 0 1 1 1 1 UBX domain DUF2418 PF10332.9 KOH00277.1 - 5.1e-19 68.6 1.5 1.4e-18 67.2 1.5 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) Nup35_RRM PF05172.13 KOH00278.1 - 3.2e-37 126.5 1.0 1.2e-36 124.7 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 KOH00278.1 - 7.4e-05 22.7 0.1 0.0012 18.8 0.1 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif CAML PF14963.6 KOH00278.1 - 2.6 8.1 6.1 6.8 6.7 6.1 1.6 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand LUC7 PF03194.15 KOH00279.1 - 8e-58 196.0 5.0 9.5e-58 195.8 5.0 1.0 1 0 0 1 1 1 1 LUC7 N_terminus CREPT PF16566.5 KOH00279.1 - 0.1 12.8 1.1 1.9 8.6 0.2 2.3 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DLH PF01738.18 KOH00280.1 - 1.5e-22 80.2 0.0 1.9e-22 79.9 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 KOH00280.1 - 0.0016 17.9 0.0 0.035 13.6 0.0 2.4 3 0 0 3 3 3 1 Prolyl oligopeptidase family 6PF2K PF01591.18 KOH00280.1 - 0.041 13.2 0.0 0.057 12.7 0.0 1.1 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Chlorophyllase PF07224.11 KOH00280.1 - 0.084 11.9 0.1 0.12 11.3 0.1 1.2 1 0 0 1 1 1 0 Chlorophyllase Chlorophyllase2 PF12740.7 KOH00280.1 - 0.14 11.1 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme LIDHydrolase PF10230.9 KOH00280.1 - 0.16 11.5 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase 4F5 PF04419.14 KOH00281.1 - 7.9e-08 33.0 13.6 7.9e-08 33.0 13.6 2.6 3 1 0 3 3 3 1 4F5 protein family PPL5 PF18168.1 KOH00281.1 - 0.00077 18.8 0.2 0.00086 18.7 0.2 1.1 1 0 0 1 1 1 1 Prim-pol family 5 DUF4407 PF14362.6 KOH00281.1 - 1.7 8.0 9.6 2 7.7 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pyr_redox_2 PF07992.14 KOH00282.1 - 9.4e-47 159.6 0.0 1.2e-46 159.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOH00282.1 - 1.4e-10 41.5 0.0 8e-09 35.9 0.0 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOH00282.1 - 0.019 14.2 0.0 1.3 8.2 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DEAD PF00270.29 KOH00283.1 - 4.5e-35 121.0 0.0 8.8e-35 120.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOH00283.1 - 7.7e-27 93.8 0.3 6.7e-25 87.6 0.3 2.7 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOH00283.1 - 6.4e-08 32.8 0.0 1.3e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Ribosomal_L13e PF01294.18 KOH00284.1 - 1.9e-67 226.6 5.3 2.9e-67 226.0 5.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L13e Tex_YqgF PF16921.5 KOH00284.1 - 0.087 13.3 0.0 0.13 12.7 0.0 1.2 1 0 0 1 1 1 0 Tex protein YqgF-like domain Ribosomal_60s PF00428.19 KOH00285.1 - 3.1e-23 82.1 5.5 3.7e-23 81.9 5.5 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein TPP_enzyme_N PF02776.18 KOH00286.1 - 3.4e-26 91.9 0.0 4.9e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 KOH00286.1 - 4.7e-22 78.2 0.0 9e-22 77.3 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 KOH00286.1 - 1.2e-14 54.4 0.0 2e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Ldh_1_C PF02866.18 KOH00287.1 - 3.9e-55 186.3 0.1 5.4e-55 185.9 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KOH00287.1 - 4.2e-44 150.1 0.1 7.4e-44 149.3 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 KOH00287.1 - 0.00045 20.6 0.1 0.0014 19.1 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 KOH00287.1 - 0.037 13.0 0.0 0.054 12.5 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Vps39_1 PF10366.9 KOH00288.1 - 2.7e-35 120.9 3.1 5.8e-35 119.8 0.5 3.1 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 KOH00288.1 - 2.2e-11 44.2 0.0 6.1e-11 42.7 0.0 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 KOH00288.1 - 0.00019 21.3 13.5 0.33 10.8 0.1 4.6 2 1 1 3 3 3 2 Region in Clathrin and VPS DUF3330 PF11809.8 KOH00288.1 - 0.06 13.4 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3330) Rxt3 PF08642.10 KOH00289.1 - 5.3e-24 85.4 0.3 3.4e-22 79.6 0.0 2.8 2 1 0 2 2 2 1 Histone deacetylation protein Rxt3 Ribosomal_L31e PF01198.19 KOH00290.1 - 5.3e-41 138.7 0.9 6.4e-41 138.5 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e BRE1 PF08647.11 KOH00291.1 - 9.2e-27 93.0 10.6 9.2e-27 93.0 10.6 6.5 4 2 1 6 6 6 2 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 KOH00291.1 - 9.6e-08 31.8 11.5 1.7e-07 30.9 11.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOH00291.1 - 9.6e-07 28.6 10.0 1.8e-06 27.7 10.0 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KOH00291.1 - 4.5e-06 26.4 12.6 8.9e-06 25.5 12.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOH00291.1 - 8.9e-06 25.6 13.6 1.7e-05 24.7 13.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOH00291.1 - 6.3e-05 22.8 14.4 0.00013 21.7 14.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOH00291.1 - 0.0013 19.1 12.2 0.0026 18.0 12.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C2H2 PF00096.26 KOH00291.1 - 0.0034 17.8 0.2 0.0034 17.8 0.2 2.8 3 0 0 3 3 2 1 Zinc finger, C2H2 type zf-RING_UBOX PF13445.6 KOH00291.1 - 0.0048 16.9 10.1 0.014 15.4 10.1 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C2H2_jaz PF12171.8 KOH00291.1 - 0.016 15.4 1.5 0.84 10.0 0.0 3.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-RING_6 PF14835.6 KOH00291.1 - 0.11 12.3 4.7 0.26 11.2 4.7 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DUF3410 PF11890.8 KOH00291.1 - 0.12 12.2 2.6 0.33 10.8 0.3 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3410) DUF4530 PF15039.6 KOH00291.1 - 0.46 10.6 0.1 0.46 10.6 0.1 2.9 2 1 1 3 3 2 0 Domain of unknown function (DUF4530) VWA_2 PF13519.6 KOH00291.1 - 4 8.1 7.6 1.6 9.4 0.2 3.8 3 2 0 4 4 4 0 von Willebrand factor type A domain zf-RING_4 PF14570.6 KOH00291.1 - 4.1 7.3 10.9 8.4 6.3 10.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FYVE PF01363.21 KOH00291.1 - 4.9 7.4 14.5 83 3.4 14.5 2.5 1 1 0 1 1 1 0 FYVE zinc finger zf-C3HC4_4 PF15227.6 KOH00291.1 - 7 6.9 10.3 21 5.4 10.3 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF1765 PF08578.10 KOH00292.1 - 1.7e-20 73.7 6.5 1.7e-20 73.7 6.5 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1765) Bap31 PF05529.12 KOH00293.1 - 5.3e-40 136.4 5.9 7.2e-40 136.0 5.9 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Spc24 PF08286.11 KOH00293.1 - 0.044 14.0 1.2 0.075 13.3 1.2 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Osmo_CC PF08946.10 KOH00293.1 - 0.045 14.0 2.0 0.087 13.1 2.0 1.4 1 0 0 1 1 1 0 Osmosensory transporter coiled coil FliT PF05400.13 KOH00293.1 - 0.099 13.5 0.7 0.18 12.7 0.7 1.4 1 0 0 1 1 1 0 Flagellar protein FliT Bromodomain PF00439.25 KOH00294.1 - 1.5e-38 130.7 3.4 2.9e-20 72.1 0.4 2.6 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 KOH00294.1 - 2.9e-10 40.1 5.6 2.9e-10 40.1 5.6 2.6 3 0 0 3 3 3 1 Bromodomain extra-terminal - transcription regulation BRCC36_C PF18110.1 KOH00294.1 - 0.083 13.1 0.5 0.33 11.1 0.5 2.0 1 0 0 1 1 1 0 BRCC36 C-terminal helical domain SWIRM-assoc_1 PF16495.5 KOH00294.1 - 0.23 11.4 3.8 0.54 10.3 3.8 1.6 1 0 0 1 1 1 0 SWIRM-associated region 1 DUF4094 PF13334.6 KOH00294.1 - 1 9.8 3.6 0.69 10.4 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) ENTH PF01417.20 KOH00295.1 - 0.045 13.8 0.1 0.045 13.8 0.1 2.2 2 1 0 2 2 2 0 ENTH domain FSH1 PF03959.13 KOH00296.1 - 0.0071 16.0 0.0 0.0071 16.0 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Iso_dh PF00180.20 KOH00297.1 - 5.6e-71 239.5 0.0 6.6e-71 239.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase NTP_transf_6 PF06042.11 KOH00297.1 - 0.077 12.8 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase DUF4355 PF14265.6 KOH00297.1 - 0.63 10.3 3.0 9.5 6.5 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) Pex19 PF04614.12 KOH00298.1 - 3.4e-60 203.8 15.2 5.1e-60 203.3 15.2 1.2 1 0 0 1 1 1 1 Pex19 protein family RsbRD_N PF14361.6 KOH00298.1 - 0.008 16.9 2.4 2.5 8.8 0.1 2.9 3 0 0 3 3 3 2 RsbT co-antagonist protein rsbRD N-terminal domain GET2 PF08690.10 KOH00298.1 - 0.023 14.4 0.9 0.023 14.4 0.9 2.2 1 1 0 2 2 2 0 GET complex subunit GET2 Eno-Rase_FAD_bd PF07055.12 KOH00298.1 - 0.052 14.0 1.6 0.46 10.9 0.1 2.8 2 1 1 3 3 3 0 Enoyl reductase FAD binding domain Myb_DNA-bind_3 PF12776.7 KOH00298.1 - 0.097 13.7 1.6 1.3 10.1 0.2 2.6 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain BCDHK_Adom3 PF10436.9 KOH00298.1 - 0.099 12.5 0.2 0.37 10.6 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase D5_N PF08706.11 KOH00298.1 - 0.32 11.2 2.8 21 5.4 2.9 3.1 1 1 0 1 1 1 0 D5 N terminal like zf-ZPR1 PF03367.13 KOH00298.1 - 0.92 9.3 3.1 1.3 8.8 0.2 2.4 2 1 0 2 2 2 0 ZPR1 zinc-finger domain RTP1_C1 PF10363.9 KOH00299.1 - 0.034 14.3 0.9 0.66 10.2 0.2 2.9 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Ribosomal_S14 PF00253.21 KOH00300.1 - 7.2e-15 54.5 3.6 8e-15 54.4 3.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e RIBIOP_C PF04950.12 KOH00301.1 - 2e-107 359.0 0.0 2e-107 359.0 0.0 1.7 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 KOH00301.1 - 9.2e-23 80.1 0.0 2.8e-22 78.6 0.0 1.9 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Rad52_Rad22 PF04098.15 KOH00302.1 - 7.7e-47 159.0 0.1 9.9e-47 158.7 0.1 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Uso1_p115_head PF04869.14 KOH00303.1 - 1.6e-103 346.1 4.0 1.6e-103 346.1 4.0 2.5 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 KOH00303.1 - 3.6e-15 56.5 35.2 3.6e-15 56.5 35.2 14.4 2 1 12 14 14 14 3 Uso1 / p115 like vesicle tethering protein, C terminal region SHE3 PF17078.5 KOH00303.1 - 0.0018 18.0 24.1 0.0018 18.0 24.1 10.0 1 1 9 10 10 10 2 SWI5-dependent HO expression protein 3 TPR_MLP1_2 PF07926.12 KOH00303.1 - 0.002 18.2 54.0 0.0033 17.5 21.8 12.2 1 1 10 12 12 12 7 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 KOH00303.1 - 0.0025 18.3 52.0 0.0042 17.6 20.0 13.9 2 1 12 14 14 14 3 Apg6 coiled-coil region DUF1664 PF07889.12 KOH00303.1 - 0.0035 17.4 5.4 0.0035 17.4 5.4 13.3 3 2 14 17 17 17 5 Protein of unknown function (DUF1664) Spc7 PF08317.11 KOH00303.1 - 0.0042 16.0 254.4 0.0036 16.2 27.5 10.5 1 1 10 11 11 11 8 Spc7 kinetochore protein GAS PF13851.6 KOH00303.1 - 0.0048 16.3 22.1 0.0048 16.3 22.1 11.4 1 1 8 10 10 10 6 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 KOH00303.1 - 0.062 10.8 211.9 0.018 12.6 28.4 5.8 1 1 3 5 5 5 0 Protein of unknown function (DUF3584) Hydrolase_4 PF12146.8 KOH00304.1 - 4e-10 39.4 0.0 4.1e-08 32.8 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOH00304.1 - 2.2e-06 28.4 0.0 2.1e-05 25.3 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOH00304.1 - 0.0011 18.7 0.0 0.99 9.0 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold AAA_31 PF13614.6 KOH00304.1 - 0.014 15.3 0.0 0.029 14.3 0.0 1.5 2 0 0 2 2 2 0 AAA domain SurA_N_2 PF13623.6 KOH00304.1 - 0.09 12.6 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 SurA N-terminal domain Peptidase_S15 PF02129.18 KOH00304.1 - 0.13 11.8 0.0 0.33 10.5 0.0 1.7 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Ank_4 PF13637.6 KOH00305.1 - 1.9e-11 44.3 0.2 5.2e-07 30.1 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOH00305.1 - 6.2e-11 42.3 0.0 0.00093 19.5 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOH00305.1 - 1.1e-09 38.8 0.0 0.00065 20.2 0.0 3.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) KilA-N PF04383.13 KOH00305.1 - 5.3e-08 32.7 2.0 2.3e-07 30.7 0.5 2.8 2 1 0 2 2 2 1 KilA-N domain Ank_3 PF13606.6 KOH00305.1 - 0.00064 20.0 0.1 0.099 13.2 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 KOH00305.1 - 0.00072 19.9 0.0 23 5.6 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat NTP_transferase PF00483.23 KOH00306.1 - 1.2e-54 185.6 0.0 1.4e-54 185.3 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 KOH00306.1 - 1.5e-10 41.6 0.0 1.9e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 KOH00306.1 - 5.5e-10 38.6 6.7 2.2e-07 30.3 2.1 3.6 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 KOH00306.1 - 0.0021 16.3 0.6 0.0032 15.7 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 KOH00306.1 - 0.0042 16.8 4.3 0.062 13.1 0.9 3.1 4 0 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 KOH00306.1 - 0.034 13.1 0.1 0.35 9.7 0.1 2.0 2 0 0 2 2 2 0 L-fucokinase CTP_transf_3 PF02348.19 KOH00306.1 - 0.091 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase MFS_1 PF07690.16 KOH00307.1 - 2.6e-15 56.2 24.8 4.4e-15 55.5 24.8 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily EphA2_TM PF14575.6 KOH00307.1 - 0.18 12.7 0.0 0.9 10.5 0.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DivIVA PF05103.13 KOH00308.1 - 0.057 13.5 0.1 0.057 13.5 0.1 1.6 2 0 0 2 2 2 0 DivIVA protein DUF2742 PF10888.8 KOH00308.1 - 0.083 13.1 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2742) Striatin PF08232.12 KOH00308.1 - 6.9 7.2 8.4 6.9 7.2 7.3 1.7 1 1 0 1 1 1 0 Striatin family Acyltransferase PF01553.21 KOH00309.1 - 1.7e-32 111.8 0.0 2.7e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase La PF05383.17 KOH00310.1 - 1e-21 76.7 0.0 2.4e-21 75.5 0.0 1.7 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 KOH00310.1 - 2.8e-07 30.2 0.1 1.2e-06 28.2 0.1 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Thr_dehydrat_C PF00585.18 KOH00310.1 - 0.052 13.3 0.1 0.1 12.4 0.1 1.5 1 0 0 1 1 1 0 C-terminal regulatory domain of Threonine dehydratase RXT2_N PF08595.11 KOH00310.1 - 0.09 12.8 7.4 0.17 11.9 7.4 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal KRE9 PF05390.11 KOH00311.1 - 4.5e-48 162.2 6.9 1e-47 161.0 6.9 1.7 1 0 0 1 1 1 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.9 KOH00311.1 - 1.7e-10 41.5 0.5 1.7e-10 41.5 0.5 2.3 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family zf-C2H2_4 PF13894.6 KOH00312.1 - 3.7e-07 30.4 20.5 0.00075 20.1 1.1 5.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOH00312.1 - 0.00048 20.1 0.4 0.00048 20.1 0.4 4.2 3 1 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.26 KOH00312.1 - 0.00079 19.7 1.9 0.00079 19.7 1.9 5.1 4 1 0 4 4 4 1 Zinc finger, C2H2 type Zn-C2H2_12 PF18112.1 KOH00312.1 - 0.0021 18.5 1.8 1.7 9.2 0.1 3.7 3 0 0 3 3 3 1 Autophagy receptor zinc finger-C2H2 domain Rad50_zn_hook PF04423.14 KOH00312.1 - 0.0046 16.8 1.6 0.15 11.9 0.2 2.7 2 0 0 2 2 2 1 Rad50 zinc hook motif zf-H2C2_2 PF13465.6 KOH00312.1 - 0.04 14.4 2.4 0.04 14.4 2.4 4.3 4 1 1 5 5 5 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KOH00312.1 - 0.04 14.2 0.1 0.04 14.2 0.1 3.7 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C3HC4_3 PF13920.6 KOH00312.1 - 0.11 12.4 4.6 6 6.8 0.2 3.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-Di19 PF05605.12 KOH00312.1 - 0.28 11.5 9.9 0.15 12.3 4.9 3.1 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Prok-RING_4 PF14447.6 KOH00312.1 - 3 7.8 6.4 14 5.6 0.1 2.9 3 0 0 3 3 2 0 Prokaryotic RING finger family 4 Prok-RING_1 PF14446.6 KOH00312.1 - 3.3 7.7 6.1 4.2 7.4 0.0 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Metallophos PF00149.28 KOH00313.1 - 1.4e-38 133.5 0.1 1.8e-38 133.1 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KOH00313.1 - 0.001 19.5 0.6 0.0022 18.4 0.6 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 KOH00313.1 - 0.04 14.1 0.0 0.064 13.4 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Glyco_hydro_65N PF03636.15 KOH00313.1 - 0.091 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain E1_DerP2_DerF2 PF02221.15 KOH00314.1 - 3.3e-29 102.0 0.0 3.9e-29 101.8 0.0 1.1 1 0 0 1 1 1 1 ML domain CHCH PF06747.13 KOH00315.1 - 4.8e-06 26.5 0.3 6.5e-06 26.1 0.3 1.2 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 KOH00315.1 - 0.00025 21.0 0.5 0.00029 20.8 0.5 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 KOH00315.1 - 0.13 12.3 1.5 0.24 11.5 1.5 1.5 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, PAPS_reduct PF01507.19 KOH00316.1 - 8.9e-40 136.6 0.0 1.2e-39 136.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family HTH_45 PF14947.6 KOH00316.1 - 0.087 12.8 0.4 0.18 11.8 0.1 1.6 2 0 0 2 2 2 0 Winged helix-turn-helix SF3A2 PF16835.5 KOH00318.1 - 3.8e-20 72.0 0.0 7.1e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 KOH00318.1 - 3e-06 27.4 1.5 3e-06 27.4 1.5 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type PAS_6 PF08348.11 KOH00318.1 - 0.054 13.3 0.3 0.39 10.6 0.0 2.0 1 1 1 2 2 2 0 YheO-like PAS domain zf-U1 PF06220.12 KOH00318.1 - 0.057 13.2 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 U1 zinc finger zf-C2H2_2 PF12756.7 KOH00318.1 - 0.058 13.7 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) SIR2 PF02146.17 KOH00319.1 - 2.5e-67 226.2 0.0 5.7e-67 225.1 0.0 1.6 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 KOH00319.1 - 6.6e-65 217.6 0.4 1.6e-64 216.3 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 KOH00319.1 - 0.0011 18.7 0.0 0.51 10.1 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain zf-RING_7 PF02591.15 KOH00319.1 - 0.17 12.1 1.1 6.2 7.1 0.3 3.4 3 0 0 3 3 3 0 C4-type zinc ribbon domain NARP1 PF12569.8 KOH00320.1 - 1.7e-115 386.9 20.7 2e-81 274.5 1.5 3.0 3 0 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 KOH00320.1 - 8.6e-13 47.4 7.8 0.015 15.4 0.0 7.4 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOH00320.1 - 4.2e-10 39.6 0.1 0.12 13.3 0.0 6.8 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOH00320.1 - 1.7e-09 38.2 1.0 0.0043 17.7 0.0 5.5 7 0 0 7 7 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOH00320.1 - 8.8e-09 34.9 7.7 0.0038 17.3 0.0 7.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOH00320.1 - 1.5e-07 31.9 4.8 0.44 11.1 0.0 5.9 5 2 2 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KOH00320.1 - 1.6e-06 28.3 8.1 0.0027 17.9 0.4 4.4 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KOH00320.1 - 5e-05 23.4 5.2 1.6 9.2 0.0 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOH00320.1 - 6.3e-05 23.2 2.0 3.6 7.9 0.1 5.8 6 2 0 6 6 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOH00320.1 - 0.0035 17.0 3.5 0.048 13.4 0.1 3.6 4 0 0 4 4 4 1 TPR repeat Vesiculo_matrix PF06326.12 KOH00320.1 - 0.012 15.4 0.4 0.21 11.3 0.1 2.4 2 0 0 2 2 2 0 Vesiculovirus matrix protein Fis1_TPR_C PF14853.6 KOH00320.1 - 0.017 15.2 7.0 3.2 7.9 0.2 4.7 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_MalT PF17874.1 KOH00320.1 - 0.055 12.8 0.1 1.2 8.5 0.0 2.5 2 1 0 2 2 2 0 MalT-like TPR region TPR_20 PF14561.6 KOH00320.1 - 0.069 13.5 2.0 7.2 7.0 0.4 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOH00320.1 - 0.11 13.2 6.5 1.9 9.3 0.0 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOH00320.1 - 0.12 12.2 15.9 0.32 10.9 0.0 7.8 11 1 1 12 12 12 0 Tetratricopeptide repeat PseudoU_synth_2 PF00849.22 KOH00321.1 - 2.4e-31 109.0 1.1 5.6e-31 107.8 0.0 2.1 2 1 0 2 2 2 1 RNA pseudouridylate synthase DUF2024 PF09630.10 KOH00321.1 - 0.034 14.0 0.0 0.1 12.5 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) G6PD_N PF00479.22 KOH00321.1 - 0.13 12.9 0.5 5.5 7.6 0.0 2.5 2 0 0 2 2 2 0 Glucose-6-phosphate dehydrogenase, NAD binding domain PQQ PF01011.21 KOH00321.1 - 0.16 12.0 0.1 0.58 10.2 0.1 1.9 1 0 0 1 1 1 0 PQQ enzyme repeat DUF3919 PF13057.6 KOH00321.1 - 0.19 11.3 4.6 0.33 10.5 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) Git3 PF11710.8 KOH00322.1 - 1.9e-87 292.3 7.8 3.4e-87 291.5 7.8 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 KOH00322.1 - 1.1e-33 115.1 2.5 3.5e-33 113.5 2.5 1.9 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term LRR19-TM PF15176.6 KOH00322.1 - 0.092 12.8 0.0 0.092 12.8 0.0 3.1 2 1 0 2 2 2 0 Leucine-rich repeat family 19 TM domain PNTB PF02233.16 KOH00322.1 - 0.57 9.0 1.7 0.91 8.4 1.7 1.2 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit Tim54 PF11711.8 KOH00322.1 - 0.63 8.8 7.0 1.8 7.3 7.0 1.8 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 2TM PF13239.6 KOH00322.1 - 0.69 10.3 8.7 0.23 11.8 2.5 3.0 3 0 0 3 3 3 0 2TM domain Menin PF05053.13 KOH00322.1 - 0.88 7.9 13.2 1.6 7.0 13.2 1.3 1 0 0 1 1 1 0 Menin DEAD PF00270.29 KOH00323.1 - 1.4e-50 171.4 0.0 2.4e-49 167.5 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOH00323.1 - 2.8e-23 82.4 0.2 1.9e-21 76.5 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 KOH00323.1 - 9.9e-19 67.4 6.1 9.9e-19 67.4 6.1 3.2 3 0 0 3 3 3 1 DBP10CT (NUC160) domain ERCC3_RAD25_C PF16203.5 KOH00323.1 - 0.025 13.8 0.0 0.025 13.8 0.0 3.1 5 0 0 5 5 5 0 ERCC3/RAD25/XPB C-terminal helicase DUF3449 PF11931.8 KOH00324.1 - 4.6e-62 209.1 0.5 4.6e-62 209.1 0.5 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) PRP9_N PF16958.5 KOH00324.1 - 3.7e-47 160.1 11.9 3.7e-47 160.1 11.9 2.3 2 0 0 2 2 2 1 Pre-mRNA-splicing factor PRP9 N-terminus SF3A3 PF16837.5 KOH00324.1 - 1.6e-14 54.2 2.6 1.6e-14 54.2 2.6 2.7 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-C2H2_jaz PF12171.8 KOH00324.1 - 7e-11 42.1 1.8 2.9e-07 30.6 0.1 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOH00324.1 - 2.5e-07 30.9 0.8 0.016 15.6 0.1 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 KOH00324.1 - 0.00013 22.5 1.4 0.52 11.3 0.1 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KOH00324.1 - 0.0054 17.0 3.3 0.15 12.4 0.2 2.7 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 KOH00324.1 - 0.13 12.8 2.9 8.7 7.0 0.5 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type Zn-C2H2_12 PF18112.1 KOH00324.1 - 0.23 12.0 2.0 0.27 11.7 0.1 2.1 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Pkinase PF00069.25 KOH00325.1 - 3.8e-51 174.0 0.0 7.7e-51 173.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00325.1 - 1e-21 77.4 0.0 2.3e-21 76.2 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 KOH00325.1 - 6.5e-05 22.7 0.1 0.12 12.0 0.0 2.8 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KOH00325.1 - 0.00045 20.2 0.0 0.39 10.6 0.0 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family PerC PF06069.11 KOH00325.1 - 0.016 15.4 0.1 0.32 11.3 0.1 3.0 3 0 0 3 3 3 0 PerC transcriptional activator RIO1 PF01163.22 KOH00325.1 - 0.02 14.5 0.2 0.049 13.2 0.2 1.7 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 KOH00327.1 - 8.7e-51 172.8 0.0 1.4e-50 172.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00327.1 - 3.1e-22 79.1 0.0 5e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOH00327.1 - 0.023 14.6 0.1 0.046 13.6 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 KOH00327.1 - 0.077 12.6 0.0 8.6 5.9 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 His_Phos_2 PF00328.22 KOH00328.1 - 4.6e-47 161.2 0.1 5.5e-47 160.9 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF4918 PF16265.5 KOH00328.1 - 0.0093 15.5 0.0 0.024 14.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4918) NAD_Gly3P_dh_N PF01210.23 KOH00329.1 - 7.3e-53 178.7 0.1 1.1e-52 178.2 0.1 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 KOH00329.1 - 5.6e-41 140.1 0.0 9.4e-41 139.4 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus His_Phos_1 PF00300.22 KOH00330.1 - 2.3e-32 112.3 0.0 3e-16 59.7 0.0 3.0 2 1 1 3 3 3 3 Histidine phosphatase superfamily (branch 1) zf-C2H2 PF00096.26 KOH00331.1 - 0.0055 17.1 14.7 0.023 15.1 0.2 3.5 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOH00331.1 - 0.2 12.6 10.3 1.4 9.9 0.1 3.7 4 0 0 4 4 4 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOH00331.1 - 0.44 11.1 4.7 2 9.0 0.2 3.0 3 0 0 3 3 3 0 Zinc-finger double domain Oxysterol_BP PF01237.18 KOH00332.1 - 2.1e-135 451.4 1.4 2.1e-135 451.4 1.4 2.2 2 1 0 2 2 2 1 Oxysterol-binding protein PH PF00169.29 KOH00332.1 - 7.8e-12 45.6 0.1 4e-11 43.3 0.1 2.4 1 0 0 1 1 1 1 PH domain Ank_5 PF13857.6 KOH00332.1 - 3.1e-11 43.3 0.1 0.0002 21.6 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOH00332.1 - 5.4e-09 36.4 0.1 0.0002 21.9 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOH00332.1 - 6.4e-09 36.3 0.0 0.00015 22.3 0.0 2.8 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOH00332.1 - 8.6e-09 34.9 0.0 0.003 17.9 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KOH00332.1 - 8.2e-07 29.2 0.2 0.00031 21.1 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat PH_8 PF15409.6 KOH00332.1 - 7.1e-06 26.2 0.0 2.3e-05 24.6 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KOH00332.1 - 9.7e-05 22.7 0.3 0.0013 19.2 0.3 3.0 1 1 0 1 1 1 1 Pleckstrin homology domain Carn_acyltransf PF00755.20 KOH00333.1 - 3.6e-196 653.3 0.1 4.2e-196 653.1 0.1 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase EMP24_GP25L PF01105.24 KOH00334.1 - 3.4e-35 121.6 0.3 4.5e-35 121.2 0.3 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Syntaxin-6_N PF09177.11 KOH00334.1 - 0.063 13.8 0.8 0.1 13.2 0.8 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF999 PF06198.11 KOH00334.1 - 0.14 12.2 0.3 0.21 11.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF999) Pkinase PF00069.25 KOH00335.1 - 1.1e-37 129.8 0.0 1.3e-20 73.9 0.0 3.3 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00335.1 - 7.3e-14 51.7 0.0 2e-08 33.8 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 KOH00335.1 - 0.0033 16.8 0.0 1.3 8.3 0.0 2.6 4 0 0 4 4 4 2 Kinase-like APH PF01636.23 KOH00335.1 - 0.0088 16.0 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 KOH00335.1 - 0.04 13.5 0.0 0.14 11.8 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 KOH00335.1 - 0.044 12.6 0.0 0.066 12.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Steroid_dh PF02544.16 KOH00336.1 - 2e-46 157.7 14.6 3.4e-46 156.9 14.6 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1304 PF06993.12 KOH00336.1 - 0.027 14.5 0.1 0.054 13.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1304) Fibrillarin PF01269.17 KOH00337.1 - 1.8e-107 357.6 0.0 2.3e-107 357.3 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 KOH00337.1 - 8.3e-06 25.7 0.1 1.6e-05 24.8 0.1 1.3 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit FtsJ PF01728.19 KOH00337.1 - 0.0081 16.3 0.0 0.01 15.9 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 KOH00337.1 - 0.068 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 KOH00337.1 - 0.082 12.5 0.0 0.17 11.5 0.0 1.5 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F zf-RING_UBOX PF13445.6 KOH00338.1 - 0.0068 16.4 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOH00338.1 - 0.016 15.1 0.1 0.042 13.7 0.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOH00338.1 - 0.017 15.0 0.1 0.046 13.6 0.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOH00338.1 - 0.018 15.0 1.4 0.027 14.4 0.0 1.9 2 0 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 KOH00338.1 - 0.11 12.4 1.8 0.11 12.3 0.1 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Apolipoprotein PF01442.18 KOH00338.1 - 1.3 8.8 16.5 0.12 12.2 11.3 1.9 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF496 PF04363.12 KOH00338.1 - 1.7 8.7 8.0 0.14 12.2 0.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF496) zf-C3HC4_3 PF13920.6 KOH00338.1 - 4.1 7.3 6.0 0.23 11.4 0.2 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Glutaredoxin PF00462.24 KOH00339.1 - 7.3e-11 42.1 0.0 1.8e-10 40.9 0.0 1.7 1 0 0 1 1 1 1 Glutaredoxin zf-ANAPC11 PF12861.7 KOH00340.1 - 2.9e-46 155.5 6.6 3.8e-46 155.1 6.6 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 KOH00340.1 - 2e-21 76.0 10.2 3.1e-21 75.4 10.2 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 KOH00340.1 - 2.4e-07 31.0 15.7 3.2e-06 27.4 15.7 2.5 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOH00340.1 - 1.7e-05 24.5 3.3 1.7e-05 24.5 3.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOH00340.1 - 0.0027 17.7 9.2 0.026 14.5 6.6 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOH00340.1 - 0.0058 16.6 12.3 0.087 12.8 13.1 2.4 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOH00340.1 - 0.017 15.0 14.5 0.13 12.1 14.6 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KOH00340.1 - 0.019 14.6 5.4 0.019 14.6 5.4 1.7 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 KOH00340.1 - 0.095 12.6 11.9 5.5 6.9 11.9 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 KOH00340.1 - 0.36 10.7 14.3 0.12 12.2 2.2 3.1 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 KOH00340.1 - 0.44 10.7 8.4 1.8 8.7 8.4 2.1 1 1 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 KOH00340.1 - 0.9 9.8 15.9 15 5.8 15.9 3.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-HC5HC2H_2 PF13832.6 KOH00340.1 - 1 9.5 7.2 0.52 10.5 4.2 1.9 1 1 1 2 2 2 0 PHD-zinc-finger like domain zf-RING_11 PF17123.5 KOH00340.1 - 1.7 8.4 10.2 10 6.0 10.2 2.3 1 1 0 1 1 1 0 RING-like zinc finger zf-HIT PF04438.16 KOH00340.1 - 4.6 7.2 9.4 0.84 9.6 4.6 2.0 2 0 0 2 2 2 0 HIT zinc finger zf-RING-like PF08746.11 KOH00340.1 - 6.8 7.1 11.3 39 4.7 11.3 2.2 1 1 0 1 1 1 0 RING-like domain AAA PF00004.29 KOH00342.1 - 2.3e-40 138.1 0.0 3.9e-40 137.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOH00342.1 - 2e-10 40.3 0.2 3.8e-10 39.4 0.2 1.4 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 KOH00342.1 - 7.5e-10 38.6 0.0 1.4e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 KOH00342.1 - 9.7e-06 25.8 0.0 2.8e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 KOH00342.1 - 2.3e-05 23.7 0.0 3.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 KOH00342.1 - 2.9e-05 24.4 0.1 0.019 15.3 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 KOH00342.1 - 0.00023 21.2 0.1 0.001 19.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOH00342.1 - 0.00055 20.3 0.0 0.0065 16.9 0.1 2.1 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 KOH00342.1 - 0.0011 18.7 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 KOH00342.1 - 0.0042 17.4 0.4 0.0086 16.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 KOH00342.1 - 0.012 16.2 0.6 0.054 14.0 0.0 2.3 3 0 0 3 3 2 0 AAA domain AAA_33 PF13671.6 KOH00342.1 - 0.015 15.5 0.0 0.032 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 KOH00342.1 - 0.016 15.1 0.0 0.038 13.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 KOH00342.1 - 0.016 15.3 0.0 0.035 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 KOH00342.1 - 0.018 14.8 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 KOH00342.1 - 0.027 13.7 0.0 0.052 12.7 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_25 PF13481.6 KOH00342.1 - 0.033 13.8 0.2 0.35 10.4 0.0 2.5 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 KOH00342.1 - 0.04 14.3 0.0 0.1 13.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 KOH00342.1 - 0.04 13.8 0.2 0.22 11.4 0.0 2.2 2 0 0 2 2 2 0 NTPase Mg_chelatase PF01078.21 KOH00342.1 - 0.055 12.8 0.1 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 KOH00342.1 - 0.06 12.5 0.1 0.6 9.2 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain PhoH PF02562.16 KOH00342.1 - 0.067 12.6 0.2 0.46 9.9 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein Zeta_toxin PF06414.12 KOH00342.1 - 0.098 11.9 0.1 0.18 11.1 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 KOH00342.1 - 0.12 12.1 0.8 0.35 10.6 0.1 2.1 3 0 0 3 3 3 0 AAA domain PP2C PF00481.21 KOH00343.1 - 5.8e-78 262.1 0.3 1.5e-77 260.7 0.3 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOH00343.1 - 0.0084 16.0 0.2 0.057 13.3 0.2 2.0 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Med2 PF11214.8 KOH00344.1 - 7.1e-34 116.0 8.7 7.1e-34 116.0 8.7 3.0 2 1 1 3 3 3 1 Mediator complex subunit 2 Utp14 PF04615.13 KOH00344.1 - 2.8 6.4 29.8 3.5 6.1 29.8 1.2 1 0 0 1 1 1 0 Utp14 protein TFIIA PF03153.13 KOH00344.1 - 5.4 6.9 37.8 8.7 6.2 37.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1682 PF07946.14 KOH00344.1 - 6.4 5.9 17.6 9.3 5.4 17.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) ATP-synt_DE_N PF02823.16 KOH00345.1 - 7.4e-18 64.2 0.0 1e-17 63.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Rad21_Rec8_N PF04825.13 KOH00346.1 - 2.2e-21 76.1 0.1 6.3e-21 74.6 0.1 1.7 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 KOH00346.1 - 1.1e-15 56.7 0.0 2.1e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein S-AdoMet_synt_N PF00438.20 KOH00346.1 - 0.15 12.8 0.5 0.53 11.0 0.2 2.0 2 0 0 2 2 2 0 S-adenosylmethionine synthetase, N-terminal domain HMG_box PF00505.19 KOH00347.1 - 4e-13 49.6 1.6 4e-13 49.6 1.6 2.6 3 1 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOH00347.1 - 2.4e-12 47.2 1.0 7.2e-12 45.7 1.0 1.8 1 0 0 1 1 1 1 HMG-box domain DUF155 PF02582.14 KOH00348.1 - 2e-56 190.9 1.7 3.2e-56 190.2 1.7 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.6 KOH00348.1 - 0.021 15.3 0.0 0.063 13.8 0.0 1.9 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Trehalase PF01204.18 KOH00349.1 - 1.1e-194 648.1 0.2 1.3e-194 647.8 0.2 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 KOH00349.1 - 4.7e-16 58.2 0.3 8.5e-16 57.4 0.3 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain OCRE PF17780.1 KOH00349.1 - 0.099 12.7 0.3 0.31 11.1 0.3 1.9 1 0 0 1 1 1 0 OCRE domain Ran_BP1 PF00638.18 KOH00350.1 - 8.8e-57 190.7 2.3 1.3e-56 190.1 2.3 1.3 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 KOH00350.1 - 5.1e-05 23.2 1.6 0.00057 19.8 1.6 2.1 1 1 0 1 1 1 1 WH1 domain VID27_PH PF17747.1 KOH00350.1 - 0.079 13.2 0.2 0.39 11.0 0.2 2.0 1 1 0 1 1 1 0 VID27 PH-like domain RCR PF12273.8 KOH00351.1 - 1.3e-28 100.1 0.0 1.7e-28 99.7 0.0 1.2 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red SNARE PF05739.19 KOH00351.1 - 0.4 10.7 3.2 0.74 9.9 3.2 1.4 1 0 0 1 1 1 0 SNARE domain Rad51 PF08423.11 KOH00352.1 - 2.3e-43 148.3 0.0 2.6e-39 135.0 0.0 2.5 2 1 0 2 2 2 2 Rad51 AAA_25 PF13481.6 KOH00352.1 - 2.2e-10 40.5 0.0 3.8e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 KOH00352.1 - 4.6e-07 29.4 0.5 1.3e-06 28.0 0.2 1.9 2 1 0 2 2 2 1 KaiC RecA PF00154.21 KOH00352.1 - 1.1e-05 25.1 0.1 2e-05 24.2 0.1 1.4 1 0 0 1 1 1 1 recA bacterial DNA recombination protein CobU PF02283.16 KOH00352.1 - 0.036 13.6 0.7 0.12 11.9 0.0 2.2 3 0 0 3 3 3 0 Cobinamide kinase / cobinamide phosphate guanyltransferase KIX_2 PF16987.5 KOH00352.1 - 0.088 12.8 0.3 0.22 11.5 0.3 1.6 1 0 0 1 1 1 0 KIX domain AAA_22 PF13401.6 KOH00352.1 - 0.12 12.6 2.1 0.52 10.6 1.1 2.5 2 1 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 KOH00352.1 - 0.88 9.2 3.1 5.9 6.5 0.1 2.7 3 0 0 3 3 3 0 Thymidylate kinase Maf1 PF09174.10 KOH00353.1 - 5.7e-38 130.8 2.4 8.4e-38 130.2 2.4 1.3 1 0 0 1 1 1 1 Maf1 regulator GST_C_3 PF14497.6 KOH00353.1 - 0.097 12.9 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Tcp11 PF05794.13 KOH00354.1 - 3.6e-138 461.4 0.5 7.5e-138 460.3 0.5 1.5 1 0 0 1 1 1 1 T-complex protein 11 SRP9-21 PF05486.12 KOH00354.1 - 2.3 8.7 6.4 0.24 11.8 0.5 2.5 2 0 0 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) PRAI PF00697.22 KOH00355.1 - 2.2e-62 210.3 0.0 2.8e-62 209.9 0.0 1.1 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GalKase_gal_bdg PF10509.9 KOH00356.1 - 4.9e-21 74.0 0.0 9.8e-21 73.1 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 KOH00356.1 - 3.7e-15 55.9 0.1 8.3e-15 54.8 0.1 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KOH00356.1 - 1.2e-09 38.4 0.0 2.6e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal DUF1748 PF08520.10 KOH00356.1 - 0.0043 16.9 0.0 0.01 15.7 0.0 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Ribosomal_L4 PF00573.22 KOH00357.1 - 1.5e-43 148.7 0.9 3e-43 147.8 0.9 1.5 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 KOH00357.1 - 1.1e-29 102.3 0.4 1.2e-28 98.9 0.2 2.3 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain PrmA PF06325.13 KOH00358.1 - 7e-12 45.3 0.0 1.4e-11 44.3 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 KOH00358.1 - 1.4e-11 45.0 0.0 3.4e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOH00358.1 - 4.5e-09 36.3 0.0 1.1e-08 35.0 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOH00358.1 - 1.8e-08 34.9 0.0 5.7e-08 33.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOH00358.1 - 3.8e-07 30.1 0.0 6.1e-07 29.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 KOH00358.1 - 8e-06 25.0 0.1 1.1e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 KOH00358.1 - 2.4e-05 23.8 0.0 3.3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 KOH00358.1 - 2.8e-05 23.7 0.0 5.9e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 KOH00358.1 - 0.00012 22.0 0.0 0.0002 21.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 KOH00358.1 - 0.00036 20.3 0.0 0.00056 19.7 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_12 PF08242.12 KOH00358.1 - 0.00067 20.3 0.0 0.002 18.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 KOH00358.1 - 0.00074 18.9 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain FtsJ PF01728.19 KOH00358.1 - 0.0044 17.1 0.0 0.014 15.6 0.0 1.7 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 KOH00358.1 - 0.015 15.3 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 KOH00358.1 - 0.018 14.8 0.0 0.027 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PRMT5 PF05185.16 KOH00358.1 - 0.054 13.3 0.0 0.094 12.6 0.0 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Met_10 PF02475.16 KOH00358.1 - 0.056 13.2 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein DOT1 PF08123.13 KOH00358.1 - 0.078 12.5 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Histone methylation protein DOT1 Cons_hypoth95 PF03602.15 KOH00358.1 - 0.094 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PNP_phzG_C PF10590.9 KOH00359.1 - 2.9e-21 75.3 2.7 7e-21 74.0 2.7 1.7 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 KOH00359.1 - 2.6e-14 53.2 0.0 3.7e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 KOH00359.1 - 0.017 15.7 0.0 0.028 15.0 0.0 1.5 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 KOH00359.1 - 0.2 11.2 1.1 3 7.4 0.0 2.5 2 1 1 3 3 3 0 Pyridoxamine 5'-phosphate oxidase like CSG2 PF16965.5 KOH00360.1 - 4.5e-182 605.4 10.4 5.1e-182 605.2 10.4 1.0 1 0 0 1 1 1 1 Ceramide synthase regulator EamA PF00892.20 KOH00360.1 - 4.7 7.4 28.9 1.8 8.7 5.2 4.1 4 1 1 5 5 5 0 EamA-like transporter family SCO1-SenC PF02630.14 KOH00361.1 - 7.6e-45 152.1 0.0 1.1e-44 151.6 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 KOH00361.1 - 0.00052 19.9 0.0 0.0012 18.8 0.0 1.6 1 1 0 1 1 1 1 AhpC/TSA family Chitin_synth_1 PF01644.17 KOH00362.1 - 4.7e-69 231.5 0.3 7.2e-69 230.9 0.3 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.15 KOH00362.1 - 1.2e-23 83.6 3.8 6.8e-19 67.9 0.0 3.0 3 0 0 3 3 3 2 Chitin synthase Chitin_synth_1N PF08407.11 KOH00362.1 - 7.3e-22 77.1 0.1 1.9e-21 75.8 0.1 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Glyco_trans_2_3 PF13632.6 KOH00362.1 - 2.3e-07 31.0 1.1 2.3e-07 31.0 1.1 2.2 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 KOH00362.1 - 2.6e-07 30.8 0.0 9.9e-07 28.9 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Ant_C PF05586.11 KOH00362.1 - 0.1 13.2 0.7 1.1 9.9 0.7 2.4 1 1 0 1 1 1 0 Anthrax receptor C-terminus region ATP-synt PF00231.19 KOH00363.1 - 2.8e-73 247.1 6.1 3.3e-73 246.8 6.1 1.0 1 0 0 1 1 1 1 ATP synthase MecA_N PF05223.11 KOH00363.1 - 0.013 15.7 3.6 0.031 14.5 3.6 1.6 1 0 0 1 1 1 0 NTF2-like N-terminal transpeptidase domain Fig1 PF12351.8 KOH00364.1 - 1.2e-57 194.9 3.3 1.2e-57 194.9 3.3 1.9 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 KOH00364.1 - 0.00015 21.4 11.9 0.00021 21.0 11.9 1.2 1 0 0 1 1 1 1 SUR7/PalI family PIG-P PF08510.12 KOH00364.1 - 0.46 10.4 6.5 0.52 10.2 2.5 2.4 2 0 0 2 2 2 0 PIG-P AMP-binding PF00501.28 KOH00365.1 - 5.6e-54 183.3 0.0 7e-54 183.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOH00365.1 - 0.0044 18.0 0.0 0.0082 17.1 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Renin_r PF07850.14 KOH00365.1 - 0.047 14.3 0.0 0.2 12.3 0.0 2.0 2 0 0 2 2 2 0 Renin receptor-like protein Acyltransferase PF01553.21 KOH00366.1 - 6.4e-36 122.9 0.0 9.9e-36 122.3 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 KOH00366.1 - 2.4e-13 50.0 0.0 4.8e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus MFS_1 PF07690.16 KOH00367.1 - 9.1e-29 100.5 21.6 9.1e-29 100.5 21.6 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sperm_Ag_HE2 PF05324.13 KOH00367.1 - 0.081 13.4 0.1 0.41 11.1 0.1 2.2 2 0 0 2 2 2 0 Sperm antigen HE2 BNR_6 PF15899.5 KOH00367.1 - 0.09 12.9 0.0 0.31 11.2 0.0 1.9 1 0 0 1 1 1 0 BNR-Asp box repeat INTS2 PF14750.6 KOH00368.1 - 0.027 12.0 0.0 0.044 11.4 0.0 1.2 1 0 0 1 1 1 0 Integrator complex subunit 2 SecD-TM1 PF13721.6 KOH00369.1 - 0.036 14.5 0.3 0.5 10.8 0.0 2.3 2 0 0 2 2 2 0 SecD export protein N-terminal TM region ADH_zinc_N PF00107.26 KOH00370.1 - 1.9e-24 86.1 0.0 3.1e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOH00370.1 - 2e-15 58.0 0.0 4e-15 57.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOH00370.1 - 1.2e-08 34.7 0.0 2.2e-08 33.9 0.0 1.5 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 KOH00370.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase FMP23 PF17315.2 KOH00371.1 - 3.9e-66 221.9 1.3 4.6e-66 221.6 1.3 1.0 1 0 0 1 1 1 1 Found in mitochondrial proteome Ribosomal_S17_N PF16205.5 KOH00372.1 - 7.4e-32 109.5 0.8 1.4e-31 108.7 0.8 1.5 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 KOH00372.1 - 2.3e-27 94.9 4.7 2.3e-27 94.9 4.7 1.7 2 0 0 2 2 2 1 Ribosomal protein S17 DUF922 PF06037.11 KOH00372.1 - 0.04 13.7 0.0 0.065 13.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) Myb_DNA-binding PF00249.31 KOH00373.1 - 7.1e-18 64.5 23.7 6.8e-12 45.4 1.6 5.0 5 0 0 5 5 5 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOH00373.1 - 1.4e-16 60.5 11.7 1.3e-12 47.8 2.1 4.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain RskA PF10099.9 KOH00373.1 - 0.0046 17.3 0.6 0.089 13.1 1.6 2.3 2 0 0 2 2 2 1 Anti-sigma-K factor rskA SANT_DAMP1_like PF16282.5 KOH00373.1 - 0.03 14.5 0.1 0.1 12.8 0.1 1.9 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_4 PF13837.6 KOH00373.1 - 0.089 13.2 0.4 0.089 13.2 0.4 5.1 5 1 0 5 5 5 0 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 KOH00373.1 - 0.39 11.1 8.6 2.2 8.6 0.5 4.5 2 2 1 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF1752 PF08550.10 KOH00374.1 - 4e-06 26.6 0.8 1.2e-05 25.1 0.1 2.2 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) FMN_red PF03358.15 KOH00375.1 - 0.068 12.9 0.0 0.094 12.5 0.0 1.2 1 0 0 1 1 1 0 NADPH-dependent FMN reductase SGL PF08450.12 KOH00376.1 - 3.2e-50 171.0 0.0 3.8e-50 170.8 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 KOH00376.1 - 0.0049 17.1 0.0 3.3 8.0 0.0 2.8 3 0 0 3 3 3 2 Arylesterase Bac_rhodopsin PF01036.18 KOH00377.1 - 3e-39 134.9 17.1 3.9e-39 134.5 17.1 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein Phage_holin_1 PF04531.13 KOH00377.1 - 0.091 13.3 0.1 0.37 11.4 0.1 2.0 1 0 0 1 1 1 0 Bacteriophage holin RNA_polI_A34 PF08208.11 KOH00377.1 - 0.17 11.9 14.0 0.24 11.5 14.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 SR-25 PF10500.9 KOH00377.1 - 1 8.9 18.7 1.4 8.5 18.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.11 KOH00377.1 - 4.6 7.5 15.6 6.1 7.0 15.6 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 GpcrRhopsn4 PF10192.9 KOH00377.1 - 6.6 6.0 16.6 1.1 8.6 5.6 2.2 1 1 1 2 2 2 0 Rhodopsin-like GPCR transmembrane domain PRP1_N PF06424.12 KOH00378.1 - 8.3e-21 74.9 15.3 8.3e-21 74.9 15.3 3.1 2 1 0 2 2 2 1 PRP1 splicing factor, N-terminal TPR_19 PF14559.6 KOH00378.1 - 3.8e-18 65.8 0.0 0.0059 17.1 0.8 7.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOH00378.1 - 1.1e-17 63.1 0.1 0.017 15.9 0.1 10.6 9 4 2 11 11 10 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOH00378.1 - 1.9e-06 27.6 6.0 3.7 7.9 0.0 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOH00378.1 - 3.7e-06 26.9 1.4 18 6.0 0.0 7.3 7 0 0 7 7 6 0 Tetratricopeptide repeat SPO22 PF08631.10 KOH00378.1 - 1.4e-05 24.7 4.6 0.19 11.2 0.1 4.0 2 1 0 3 3 3 2 Meiosis protein SPO22/ZIP4 like TPR_16 PF13432.6 KOH00378.1 - 0.00044 20.8 0.0 34 5.2 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOH00378.1 - 0.0018 18.0 1.7 11 6.1 0.0 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOH00378.1 - 0.008 16.1 1.4 26 5.1 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOH00378.1 - 0.024 14.9 3.3 13 6.2 0.0 5.3 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOH00378.1 - 0.091 13.0 14.3 0.74 10.2 0.0 6.5 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOH00378.1 - 0.15 12.7 9.5 1.1e+02 3.8 0.0 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat Wtap PF17098.5 KOH00380.1 - 4.6e-08 33.1 14.4 1.6e-07 31.4 14.1 1.9 1 1 0 1 1 1 1 WTAP/Mum2p family TMF_TATA_bd PF12325.8 KOH00380.1 - 0.28 11.4 14.5 1.8 8.8 1.0 2.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4407 PF14362.6 KOH00380.1 - 0.45 9.8 4.6 0.68 9.2 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prefoldin_2 PF01920.20 KOH00380.1 - 0.97 9.4 15.9 0.25 11.3 4.6 3.1 3 0 0 3 3 3 0 Prefoldin subunit DUF641 PF04859.12 KOH00380.1 - 4.2 7.7 14.8 1.1 9.6 0.9 3.1 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) UCH PF00443.29 KOH00381.1 - 1.6e-45 155.6 0.3 3.1e-45 154.7 0.3 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KOH00381.1 - 1.9e-19 69.7 7.4 1.9e-19 69.7 7.4 3.2 3 1 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 KOH00381.1 - 7.2e-19 68.5 0.1 7.2e-19 68.5 0.1 3.2 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 KOH00381.1 - 3.1e-13 49.3 0.0 2.1e-08 33.9 0.1 2.7 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP_var PF17807.1 KOH00381.1 - 5.3e-10 38.9 11.4 7.8e-10 38.4 5.3 3.0 2 1 0 2 2 2 1 Variant UBP zinc finger UBA_5 PF16577.5 KOH00381.1 - 0.12 12.6 0.1 27 5.0 0.0 2.6 2 0 0 2 2 2 0 UBA domain TFIIS_C PF01096.18 KOH00381.1 - 2.3 8.1 5.5 15 5.5 0.2 3.8 4 0 0 4 4 4 0 Transcription factor S-II (TFIIS) Pkinase PF00069.25 KOH00383.1 - 1.1e-35 123.3 0.2 1.1e-35 123.3 0.2 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00383.1 - 7.3e-23 81.2 0.0 1.5e-22 80.1 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOH00383.1 - 0.0027 17.7 0.0 0.71 9.8 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family ORC2 PF04084.14 KOH00384.1 - 1.7e-110 369.0 0.6 2.2e-110 368.7 0.6 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 AT_hook PF02178.19 KOH00384.1 - 0.085 12.8 2.7 0.27 11.3 2.7 1.9 1 0 0 1 1 1 0 AT hook motif tRNA-synt_2 PF00152.20 KOH00385.1 - 7.7e-76 255.2 0.1 1.1e-75 254.6 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOH00385.1 - 2.1e-12 46.9 0.2 5.1e-12 45.6 0.2 1.7 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KOH00385.1 - 4.8e-07 29.5 0.0 0.0039 16.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FtsJ PF01728.19 KOH00386.1 - 6.1e-67 225.2 0.0 7.8e-67 224.8 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 KOH00386.1 - 0.06 13.2 0.0 0.088 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltr_RsmB-F PF01189.17 KOH00386.1 - 0.17 11.5 0.2 0.64 9.6 0.1 2.1 2 1 0 2 2 2 0 16S rRNA methyltransferase RsmB/F zf-C2H2 PF00096.26 KOH00390.1 - 0.00059 20.1 20.0 0.014 15.8 4.5 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOH00390.1 - 0.0016 19.1 15.4 0.19 12.7 2.8 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOH00390.1 - 0.0021 18.4 2.5 0.0021 18.4 2.5 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.7 KOH00390.1 - 1.2 9.7 8.3 0.29 11.6 1.1 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type SRP1_TIP1 PF00660.17 KOH00391.1 - 2.5e-34 117.3 0.4 4.5e-34 116.5 0.4 1.4 1 0 0 1 1 1 1 Seripauperin and TIP1 family SPX PF03105.19 KOH00391.1 - 0.34 10.8 5.7 0.32 10.9 5.7 1.1 1 0 0 1 1 1 0 SPX domain QWRF PF04484.12 KOH00391.1 - 0.8 9.4 13.5 1 9.0 13.5 1.3 1 0 0 1 1 1 0 QWRF family DUF3275 PF11679.8 KOH00391.1 - 2.6 8.0 4.6 4.5 7.2 4.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) Miga PF10265.9 KOH00391.1 - 3.3 6.6 8.0 3.9 6.3 8.0 1.2 1 0 0 1 1 1 0 Mitoguardin Apt1 PF10351.9 KOH00391.1 - 8.9 5.0 9.6 10 4.9 9.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain AA_permease PF00324.21 KOH00392.1 - 3e-142 474.6 36.8 3.8e-142 474.3 36.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOH00392.1 - 1.3e-34 119.8 33.5 1.7e-34 119.4 33.5 1.0 1 0 0 1 1 1 1 Amino acid permease DUF2207 PF09972.9 KOH00392.1 - 0.34 9.6 0.0 0.34 9.6 0.0 3.4 3 1 0 3 3 3 0 Predicted membrane protein (DUF2207) AA_permease PF00324.21 KOH00393.1 - 4e-126 421.4 38.1 4.7e-126 421.2 38.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOH00393.1 - 1.4e-40 139.4 37.3 1.8e-40 139.1 37.3 1.1 1 0 0 1 1 1 1 Amino acid permease ROK PF00480.20 KOH00393.1 - 0.26 10.7 1.2 0.42 10.0 1.2 1.2 1 0 0 1 1 1 0 ROK family Alg14 PF08660.11 KOH00394.1 - 5.1e-55 186.1 0.9 5.5e-55 186.0 0.1 1.4 2 0 0 2 2 2 1 Oligosaccharide biosynthesis protein Alg14 like HSP20 PF00011.21 KOH00396.1 - 1e-26 93.0 2.5 1.4e-26 92.6 2.5 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KOH00396.1 - 8e-07 28.5 0.0 1.4e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Ntox50 PF15542.6 KOH00396.1 - 0.024 15.4 0.1 0.046 14.5 0.1 1.4 1 0 0 1 1 1 0 Bacterial toxin 50 Pih1_fungal_CS PF18482.1 KOH00396.1 - 0.029 14.9 1.1 0.05 14.1 0.5 1.9 1 1 0 1 1 1 0 Fungal Pih1 CS domain SNF2_N PF00176.23 KOH00397.1 - 1.9e-66 224.2 0.0 2.8e-66 223.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOH00397.1 - 5.1e-15 55.8 0.0 1.7e-14 54.1 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOH00397.1 - 3.2e-11 43.5 0.9 1.8e-10 41.1 0.0 2.7 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KOH00397.1 - 9.7e-08 31.5 0.2 0.00033 19.9 0.1 2.5 2 0 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 DUF2439 PF10382.9 KOH00397.1 - 1.4e-05 25.3 0.1 4.9e-05 23.6 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) Peptidase_M28 PF04389.17 KOH00398.1 - 2.1e-41 141.8 0.0 3.6e-41 141.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M42 PF05343.14 KOH00398.1 - 0.0086 15.1 0.0 0.025 13.6 0.0 1.6 1 1 0 2 2 2 1 M42 glutamyl aminopeptidase Peptidase_M20 PF01546.28 KOH00398.1 - 0.013 15.2 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 DUF2189 PF09955.9 KOH00398.1 - 0.02 15.2 1.9 0.028 14.7 0.0 2.2 3 0 0 3 3 3 0 Predicted integral membrane protein (DUF2189) DUF4451 PF14616.6 KOH00399.1 - 7.1e-07 29.5 3.4 7.1e-07 29.5 3.4 2.8 3 2 0 3 3 3 1 Domain of unknown function (DUF4451) SLM4 PF16818.5 KOH00400.1 - 2.5e-60 203.1 1.8 2.8e-60 203.0 1.8 1.0 1 0 0 1 1 1 1 Protein SLM4 DUF2322 PF10084.9 KOH00400.1 - 0.1 12.6 0.0 2 8.5 0.0 2.2 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2322) Recep_L_domain PF01030.24 KOH00401.1 - 5.7e-06 26.4 3.5 0.018 15.1 0.4 3.3 1 1 2 3 3 3 2 Receptor L domain LRR_9 PF14580.6 KOH00401.1 - 0.0089 15.5 0.3 0.02 14.4 0.2 1.6 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KOH00401.1 - 0.51 10.8 12.4 0.22 12.0 1.2 4.4 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) Ashwin PF15323.6 KOH00401.1 - 3.7 7.5 9.3 7.4 6.5 9.3 1.5 1 0 0 1 1 1 0 Developmental protein PCI PF01399.27 KOH00402.1 - 4.4e-08 33.6 3.5 7.3e-07 29.7 0.6 3.6 2 1 1 3 3 3 1 PCI domain AAA PF00004.29 KOH00403.1 - 3.3e-50 169.9 0.0 1.7e-37 128.8 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.17 KOH00403.1 - 4.7e-11 42.3 1.2 1.6e-10 40.6 0.2 2.2 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_lid_3 PF17862.1 KOH00403.1 - 2e-10 40.3 0.1 5.6e-10 38.9 0.1 1.9 1 1 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 KOH00403.1 - 4.3e-10 40.0 0.2 8.9e-05 22.8 0.0 3.3 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KOH00403.1 - 1.7e-09 38.3 0.0 0.00089 19.7 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain CDC48_N PF02359.18 KOH00403.1 - 2.4e-07 30.8 0.0 1.1e-06 28.7 0.0 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain TIP49 PF06068.13 KOH00403.1 - 7.1e-07 28.7 0.1 0.034 13.4 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 KOH00403.1 - 8.5e-07 29.2 0.0 0.0064 16.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 KOH00403.1 - 1.3e-06 28.5 0.2 0.0022 18.0 0.0 3.0 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KOH00403.1 - 1.5e-06 27.8 0.2 0.002 17.6 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 KOH00403.1 - 1.1e-05 25.3 0.2 0.095 12.4 0.0 2.8 2 1 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 KOH00403.1 - 1.1e-05 25.7 0.1 0.1 13.0 0.0 3.5 3 0 0 3 3 3 2 RNA helicase NACHT PF05729.12 KOH00403.1 - 1.8e-05 24.7 2.4 0.023 14.6 0.1 3.4 4 0 0 4 4 3 2 NACHT domain AAA_18 PF13238.6 KOH00403.1 - 2.1e-05 25.0 0.0 0.54 10.8 0.0 3.2 3 0 0 3 3 2 2 AAA domain RuvB_N PF05496.12 KOH00403.1 - 3.5e-05 23.6 0.7 0.092 12.5 0.1 3.0 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain PhoH PF02562.16 KOH00403.1 - 4.1e-05 23.1 0.0 0.047 13.1 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein NB-ARC PF00931.22 KOH00403.1 - 4.7e-05 22.7 0.1 0.03 13.5 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain AAA_2 PF07724.14 KOH00403.1 - 7.4e-05 22.9 0.0 0.0027 17.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TsaE PF02367.17 KOH00403.1 - 7.6e-05 22.7 0.0 0.76 9.8 0.0 3.1 3 0 0 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2075 PF09848.9 KOH00403.1 - 0.00026 20.4 0.0 0.34 10.1 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) Sigma54_activat PF00158.26 KOH00403.1 - 0.00026 20.7 0.0 0.66 9.7 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_7 PF12775.7 KOH00403.1 - 0.00031 20.3 0.0 0.071 12.6 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 KOH00403.1 - 0.00037 20.3 0.0 0.26 11.0 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_30 PF13604.6 KOH00403.1 - 0.00042 20.1 0.0 0.72 9.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 KOH00403.1 - 0.00055 20.0 0.0 0.85 9.6 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit ABC_tran PF00005.27 KOH00403.1 - 0.00087 19.8 1.0 0.11 13.0 0.1 2.7 3 0 0 3 3 2 1 ABC transporter ATPase_2 PF01637.18 KOH00403.1 - 0.001 19.1 0.4 0.6 10.0 0.0 3.2 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_11 PF13086.6 KOH00403.1 - 0.0019 18.0 0.0 0.62 9.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 KOH00403.1 - 0.0021 17.5 0.0 2.8 7.3 0.0 3.2 2 1 0 2 2 2 1 Bacterial TniB protein ATPase PF06745.13 KOH00403.1 - 0.0024 17.3 0.4 0.28 10.5 0.1 2.6 2 0 0 2 2 2 1 KaiC AAA_14 PF13173.6 KOH00403.1 - 0.0043 17.1 0.0 4.4 7.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KOH00403.1 - 0.0073 16.8 2.0 5 7.6 0.3 3.0 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 KOH00403.1 - 0.01 16.1 0.1 1.2 9.4 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 KOH00403.1 - 0.014 15.9 0.4 4.7 7.6 0.0 2.9 3 0 0 3 3 2 0 AAA domain AAA_28 PF13521.6 KOH00403.1 - 0.017 15.4 0.0 3.6 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain IPT PF01745.16 KOH00403.1 - 0.017 14.5 0.1 0.13 11.6 0.0 2.1 2 0 0 2 2 2 0 Isopentenyl transferase Rad17 PF03215.15 KOH00403.1 - 0.017 15.1 0.1 4 7.3 0.0 2.8 2 1 0 2 2 2 0 Rad17 P-loop domain AAA_25 PF13481.6 KOH00403.1 - 0.02 14.5 2.2 4.5 6.8 0.1 2.9 2 1 1 3 3 3 0 AAA domain Cytidylate_kin PF02224.18 KOH00403.1 - 0.022 14.5 0.1 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase AAA_3 PF07726.11 KOH00403.1 - 0.033 14.1 0.0 0.26 11.1 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 KOH00403.1 - 0.034 13.2 0.0 3.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 T2SSE PF00437.20 KOH00403.1 - 0.04 13.0 0.0 7.2 5.6 0.0 2.6 2 0 0 2 2 2 0 Type II/IV secretion system protein Bac_DnaA PF00308.18 KOH00403.1 - 0.047 13.5 0.0 13 5.5 0.0 2.8 3 0 0 3 3 3 0 Bacterial dnaA protein AAA_29 PF13555.6 KOH00403.1 - 0.069 12.9 0.1 5.7 6.8 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Vps4_C PF09336.10 KOH00403.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain Bromodomain PF00439.25 KOH00404.1 - 1.2e-15 57.3 0.2 4.8e-15 55.4 0.2 2.1 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 KOH00404.1 - 0.00095 19.1 0.0 0.0028 17.6 0.0 1.8 1 0 0 1 1 1 1 Bromodomain associated UQ_con PF00179.26 KOH00405.1 - 6.9e-44 148.9 0.0 7.6e-44 148.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOH00405.1 - 0.00058 20.1 0.0 0.00095 19.4 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 KOH00405.1 - 0.0021 17.7 0.0 0.0025 17.5 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 KOH00405.1 - 0.0048 16.8 0.0 0.0072 16.2 0.0 1.3 1 0 0 1 1 1 1 UEV domain TEA PF01285.18 KOH00406.1 - 2.9e-24 84.9 0.3 6.5e-24 83.8 0.3 1.6 1 0 0 1 1 1 1 TEA/ATTS domain MCM6_C PF18263.1 KOH00406.1 - 0.0065 16.7 1.1 0.0065 16.7 1.1 1.9 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain FTHFS PF01268.19 KOH00407.1 - 3.8e-253 840.7 0.6 5.1e-253 840.3 0.6 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 KOH00407.1 - 2.3e-70 235.0 0.8 2.3e-70 235.0 0.8 2.4 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 KOH00407.1 - 3.1e-35 120.9 0.4 9.5e-35 119.4 0.2 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.15 KOH00407.1 - 0.0066 15.4 0.4 0.013 14.5 0.4 1.4 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Mito_carr PF00153.27 KOH00408.1 - 1e-68 227.3 7.5 2.3e-24 85.2 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein KH_1 PF00013.29 KOH00409.1 - 4.8e-25 87.2 1.5 2.6e-12 46.4 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 KOH00409.1 - 2e-05 24.3 0.2 0.1 12.4 0.1 2.5 2 0 0 2 2 2 2 KH domain KH_5 PF13184.6 KOH00409.1 - 0.026 14.6 0.4 2.1 8.5 0.1 2.6 2 0 0 2 2 2 0 NusA-like KH domain KH_4 PF13083.6 KOH00409.1 - 0.074 12.9 0.0 2.9 7.8 0.0 2.4 2 0 0 2 2 2 0 KH domain Spt5-NGN PF03439.13 KOH00410.1 - 0.077 12.9 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Early transcription elongation factor of RNA pol II, NGN section Anoctamin PF04547.12 KOH00411.1 - 2.1e-43 148.8 28.9 4.2e-43 147.8 28.9 1.5 1 1 0 1 1 1 1 Calcium-activated chloride channel RAMP4 PF06624.12 KOH00411.1 - 0.054 13.6 2.5 0.12 12.4 0.5 2.7 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 SelP_N PF04592.14 KOH00411.1 - 7.3 5.9 13.1 14 5.0 13.1 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DNA_pol3_delta2 PF13177.6 KOH00412.1 - 2.3e-09 37.2 3.0 3.6e-09 36.6 0.2 2.5 2 1 0 2 2 2 1 DNA polymerase III, delta subunit AAA PF00004.29 KOH00412.1 - 3.9e-06 27.3 0.1 1.1e-05 25.8 0.1 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 KOH00412.1 - 0.00051 19.9 0.5 0.0015 18.3 0.2 2.0 2 0 0 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.15 KOH00412.1 - 0.0033 17.4 0.0 0.0061 16.5 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 KOH00412.1 - 0.015 15.7 0.0 0.035 14.5 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain NYD-SP12_N PF15015.6 KOH00412.1 - 0.015 13.7 0.0 0.023 13.1 0.0 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal AAA_assoc_2 PF16193.5 KOH00412.1 - 0.023 15.0 0.2 0.15 12.5 0.0 2.2 2 0 0 2 2 2 0 AAA C-terminal domain Rep_fac_C PF08542.11 KOH00412.1 - 0.03 14.7 0.9 0.082 13.3 0.1 2.2 3 0 0 3 3 3 0 Replication factor C C-terminal domain RuvB_N PF05496.12 KOH00412.1 - 0.069 12.9 0.0 0.25 11.1 0.0 1.9 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_27 PF13514.6 KOH00412.1 - 0.093 12.3 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOH00412.1 - 0.16 12.3 0.9 1 9.6 0.2 2.6 3 1 0 3 3 3 0 AAA domain PCNA_N PF00705.18 KOH00413.1 - 3.1e-55 185.3 1.3 6.5e-55 184.3 1.3 1.5 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 KOH00413.1 - 1.2e-54 183.9 0.1 3.2e-54 182.5 0.1 1.7 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 KOH00413.1 - 0.0017 17.8 0.1 0.0022 17.5 0.1 1.2 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 KOH00413.1 - 0.0032 16.6 0.6 0.024 13.7 0.6 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 HMG_box PF00505.19 KOH00414.1 - 1.2e-23 83.2 0.1 2.2e-23 82.4 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOH00414.1 - 6.6e-17 61.9 0.2 6.6e-17 61.9 0.2 1.5 2 0 0 2 2 2 1 HMG-box domain CHDNT PF08073.12 KOH00414.1 - 0.0031 17.4 0.0 0.0053 16.7 0.0 1.3 1 0 0 1 1 1 1 CHDNT (NUC034) domain HMG_box_5 PF14887.6 KOH00414.1 - 0.024 14.6 0.2 0.024 14.6 0.2 1.6 2 0 0 2 2 2 0 HMG (high mobility group) box 5 zf-Tim10_DDP PF02953.15 KOH00415.1 - 1.5e-13 50.1 1.6 2.2e-13 49.6 1.6 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger TTL PF03133.15 KOH00416.1 - 7.7e-90 301.0 4.4 1e-89 300.6 4.4 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.17 KOH00416.1 - 2.7e-44 151.3 0.0 4.5e-44 150.6 0.0 1.4 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.6 KOH00416.1 - 0.00029 20.2 0.1 0.058 12.6 0.0 2.4 2 0 0 2 2 2 2 YheC/D like ATP-grasp Herpes_BLLF1 PF05109.13 KOH00416.1 - 0.073 11.1 0.0 0.1 10.6 0.0 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) RXT2_N PF08595.11 KOH00417.1 - 5.3e-43 146.7 2.1 5.3e-43 146.7 2.1 2.9 3 1 0 3 3 3 1 RXT2-like, N-terminal RPT PF13446.6 KOH00417.1 - 0.046 13.6 0.4 10 6.1 0.3 2.8 2 0 0 2 2 2 0 A repeated domain in UCH-protein CENP-B_dimeris PF09026.10 KOH00417.1 - 0.061 13.7 7.7 0.091 13.2 0.1 3.1 3 0 0 3 3 3 0 Centromere protein B dimerisation domain 4HBT_2 PF13279.6 KOH00418.1 - 2.7e-07 31.1 0.0 4e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily Pkinase PF00069.25 KOH00419.1 - 2.3e-23 82.9 0.8 4.1e-23 82.1 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00419.1 - 5.6e-12 45.5 0.0 1.1e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT PF02985.22 KOH00419.1 - 0.0001 22.3 2.0 5.2 7.6 0.0 5.1 5 0 0 5 5 5 2 HEAT repeat Kinase-like PF14531.6 KOH00419.1 - 0.0038 16.6 0.2 0.011 15.1 0.0 1.9 2 0 0 2 2 2 1 Kinase-like HEAT_2 PF13646.6 KOH00419.1 - 0.023 15.1 0.0 0.14 12.5 0.0 2.3 3 0 0 3 3 3 0 HEAT repeats NopRA1 PF16201.5 KOH00419.1 - 0.027 14.1 0.5 0.087 12.4 0.1 2.2 2 0 0 2 2 2 0 Nucleolar pre-ribosomal-associated protein 1 WD40 PF00400.32 KOH00419.1 - 0.04 14.8 2.5 1.4 9.9 0.0 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat HEAT_EZ PF13513.6 KOH00419.1 - 0.089 13.3 0.1 6.4 7.4 0.0 3.1 2 0 0 2 2 2 0 HEAT-like repeat RTP1_C1 PF10363.9 KOH00419.1 - 1.2 9.3 5.3 1.3 9.2 0.4 2.8 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 ERCC4 PF02732.15 KOH00420.1 - 3e-20 73.0 2.5 3e-20 73.0 2.5 2.2 2 1 1 3 3 3 1 ERCC4 domain Fes1 PF08609.10 KOH00421.1 - 8.8e-24 84.2 0.2 1.2e-22 80.6 0.1 2.6 2 1 0 2 2 2 1 Nucleotide exchange factor Fes1 DUF4704 PF15787.5 KOH00421.1 - 0.00093 18.5 1.1 0.05 12.9 0.0 2.6 1 1 2 3 3 3 1 Domain of unknown function (DUF4704) HEAT_2 PF13646.6 KOH00421.1 - 0.0013 19.1 0.0 0.029 14.8 0.0 2.7 2 1 1 3 3 3 1 HEAT repeats IBN_N PF03810.19 KOH00421.1 - 0.003 17.4 0.2 0.82 9.6 0.1 3.3 1 1 3 4 4 4 1 Importin-beta N-terminal domain Uso1_p115_head PF04869.14 KOH00421.1 - 0.0062 15.7 0.5 0.14 11.2 0.0 2.4 1 1 1 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region HEAT_EZ PF13513.6 KOH00421.1 - 0.012 16.2 0.2 0.19 12.3 0.2 2.7 1 1 0 1 1 1 0 HEAT-like repeat Atx10homo_assoc PF09759.9 KOH00421.1 - 0.071 13.1 0.3 0.91 9.6 0.0 2.4 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Exo84_C PF16528.5 KOH00422.1 - 3.9e-75 252.2 4.3 3.9e-75 252.2 4.3 2.2 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 KOH00422.1 - 1.9e-08 34.3 3.4 1.9e-08 34.3 3.4 2.5 2 0 0 2 2 2 1 Vps51/Vps67 Isochorismatase PF00857.20 KOH00422.1 - 0.032 14.4 0.3 0.11 12.7 0.2 1.8 2 0 0 2 2 2 0 Isochorismatase family COG2 PF06148.11 KOH00422.1 - 0.14 12.3 13.1 0.062 13.4 4.8 3.4 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DASH_Dad1 PF08649.10 KOH00422.1 - 1.5 9.1 7.9 36 4.6 0.2 4.1 2 1 1 3 3 3 0 DASH complex subunit Dad1 DASH_Duo1 PF08651.10 KOH00422.1 - 3.3 7.5 8.5 0.92 9.3 3.4 2.9 3 0 0 3 3 3 0 DASH complex subunit Duo1 Fzo_mitofusin PF04799.13 KOH00422.1 - 3.5 7.2 7.7 0.69 9.4 3.4 2.1 2 0 0 2 2 2 0 fzo-like conserved region WD40 PF00400.32 KOH00423.1 - 9.3e-20 70.6 15.6 1.8e-05 25.4 0.1 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00423.1 - 5.4e-14 52.3 5.9 0.0035 17.6 0.1 6.7 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 KOH00423.1 - 2.8e-08 33.4 0.1 6e-08 32.4 0.1 1.6 1 0 0 1 1 1 1 LisH WD40_like PF17005.5 KOH00423.1 - 5.7e-06 25.9 0.5 0.14 11.5 0.1 3.3 1 1 2 3 3 3 2 WD40-like domain RAB3GAP2_N PF14655.6 KOH00423.1 - 0.0036 16.6 0.0 0.0071 15.7 0.0 1.5 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Ge1_WD40 PF16529.5 KOH00423.1 - 0.071 12.1 0.0 7.2 5.5 0.0 2.9 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Mito_carr PF00153.27 KOH00424.1 - 2.4e-61 203.7 1.5 6.4e-22 77.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein P5CR_dimer PF14748.6 KOH00424.1 - 0.037 14.3 0.3 1.4 9.2 0.1 2.3 2 0 0 2 2 2 0 Pyrroline-5-carboxylate reductase dimerisation Vac_ImportDeg PF09783.9 KOH00425.1 - 1.8e-57 193.7 1.7 2.6e-57 193.2 1.7 1.2 1 0 0 1 1 1 1 Vacuolar import and degradation protein Pho88 PF10032.9 KOH00427.1 - 2.4e-81 271.4 0.5 2.7e-81 271.2 0.5 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) CENP-L PF13092.6 KOH00428.1 - 0.0003 21.1 0.0 0.00063 20.0 0.0 1.6 1 1 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 AIM3 PF17096.5 KOH00429.1 - 2.8e-31 108.3 9.3 2.8e-31 108.3 9.3 8.8 7 1 1 8 8 8 2 Altered inheritance of mitochondria protein 3 EF-hand_1 PF00036.32 KOH00430.1 - 6.7e-31 103.5 4.1 1.4e-08 33.7 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOH00430.1 - 5e-27 94.1 0.3 2.3e-14 53.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KOH00430.1 - 2.5e-26 89.3 3.7 5.5e-08 32.1 0.0 4.5 4 1 1 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 KOH00430.1 - 5e-18 63.7 4.2 4.9e-07 29.0 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOH00430.1 - 3.1e-16 58.9 5.3 3.6e-08 33.1 0.1 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 KOH00430.1 - 7.2e-13 48.7 0.0 7e-09 35.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOH00430.1 - 1.5e-06 28.5 0.1 0.0011 19.3 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 KOH00430.1 - 1.6e-05 25.2 0.1 0.21 12.0 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain UPF0154 PF03672.13 KOH00430.1 - 5.1e-05 23.2 0.0 0.015 15.3 0.0 2.9 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0154) Dockerin_1 PF00404.18 KOH00430.1 - 0.0012 18.9 0.6 0.45 10.7 0.2 2.5 1 1 1 2 2 2 2 Dockerin type I domain Caleosin PF05042.13 KOH00430.1 - 0.002 18.1 0.0 0.91 9.4 0.0 3.0 1 1 2 3 3 3 1 Caleosin related protein TerB PF05099.13 KOH00430.1 - 0.0038 17.2 0.1 0.081 12.9 0.0 2.2 2 1 0 2 2 2 1 Tellurite resistance protein TerB DUF853 PF05872.12 KOH00430.1 - 0.0044 15.7 0.3 0.11 11.0 0.1 2.0 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF853) EF-hand_4 PF12763.7 KOH00430.1 - 0.0046 16.9 0.4 0.012 15.6 0.2 1.8 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SurA_N_3 PF13624.6 KOH00430.1 - 0.017 14.9 0.5 0.7 9.7 0.2 2.0 1 1 1 2 2 2 0 SurA N-terminal domain GPHH PF16905.5 KOH00430.1 - 0.077 12.8 0.0 0.89 9.4 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated RNA_pol_Rpb4 PF03874.16 KOH00430.1 - 0.099 13.0 1.0 1.7 9.0 0.1 2.5 2 1 1 3 3 3 0 RNA polymerase Rpb4 Glycos_trans_3N PF02885.17 KOH00430.1 - 0.1 12.5 3.0 3.2 7.7 0.1 3.4 1 1 0 2 2 2 0 Glycosyl transferase family, helical bundle domain Glycos_transf_1 PF00534.20 KOH00431.1 - 3.1e-12 46.4 0.0 6e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOH00431.1 - 3.8e-06 27.4 0.0 1.1e-05 25.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KOH00431.1 - 0.0001 22.4 0.0 0.0002 21.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 KOH00431.1 - 0.0015 18.9 0.0 0.0027 18.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 KOH00431.1 - 0.048 14.1 0.0 0.068 13.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain NUDIX PF00293.28 KOH00432.1 - 1.7e-15 57.3 0.0 1e-14 54.7 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain TPR_1 PF00515.28 KOH00433.1 - 3.3e-48 159.6 21.0 2.5e-07 30.2 0.0 11.0 10 1 0 10 10 10 10 Tetratricopeptide repeat TPR_2 PF07719.17 KOH00433.1 - 2.6e-42 139.5 21.6 0.00014 21.7 0.0 10.7 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_17 PF13431.6 KOH00433.1 - 4.4e-26 89.3 31.0 0.00015 21.9 0.1 11.3 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 KOH00433.1 - 2.3e-25 86.7 17.6 0.21 11.9 0.1 11.0 10 1 0 10 10 10 6 Tetratricopeptide repeat TPR_12 PF13424.6 KOH00433.1 - 3.5e-19 68.9 29.0 0.0003 21.0 0.2 8.5 4 3 2 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 KOH00433.1 - 5e-18 63.7 18.6 0.00064 19.6 0.2 9.4 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOH00433.1 - 2.8e-17 62.1 23.1 0.0014 18.3 1.2 9.8 4 2 6 10 10 10 6 TPR repeat TPR_14 PF13428.6 KOH00433.1 - 1.4e-12 47.3 60.0 0.03 15.2 0.6 11.8 6 4 5 11 11 9 7 Tetratricopeptide repeat TPR_16 PF13432.6 KOH00433.1 - 6.5e-10 39.5 10.6 0.00063 20.3 0.1 8.0 5 3 0 7 7 6 4 Tetratricopeptide repeat TPR_9 PF13371.6 KOH00433.1 - 3.9e-09 36.5 44.2 0.00036 20.6 0.0 8.0 4 2 3 7 7 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 KOH00433.1 - 0.00046 20.0 18.1 0.24 11.3 0.7 7.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 KOH00433.1 - 0.011 16.4 52.3 0.62 10.8 0.0 12.0 11 1 0 11 11 10 0 Tetratricopeptide repeat Transmemb_17 PF09799.9 KOH00434.1 - 0.012 16.1 2.4 0.025 15.1 2.4 1.5 1 0 0 1 1 1 0 Predicted membrane protein SNF2_N PF00176.23 KOH00435.1 - 1.7e-54 184.9 0.1 5.7e-54 183.2 0.1 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOH00435.1 - 8.1e-16 58.4 0.0 9.1e-15 55.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOH00435.1 - 7e-10 39.2 0.1 1.6e-09 38.0 0.1 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOH00435.1 - 2.3e-09 37.2 0.0 5.2e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4 PF00097.25 KOH00435.1 - 7.1e-08 32.2 11.3 7.1e-08 32.2 11.3 2.4 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOH00435.1 - 0.00043 20.0 9.1 0.00043 20.0 9.1 2.5 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOH00435.1 - 0.00054 19.9 5.7 0.00054 19.9 5.7 2.1 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KOH00435.1 - 0.0022 17.8 8.3 0.0022 17.8 8.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOH00435.1 - 0.0032 17.8 9.5 0.0032 17.8 9.5 2.5 2 0 0 2 2 2 1 Ring finger domain Zn_Tnp_IS91 PF14319.6 KOH00435.1 - 0.0039 17.2 1.2 0.0039 17.2 1.2 2.5 2 0 0 2 2 2 1 Transposase zinc-binding domain MH2 PF03166.14 KOH00435.1 - 0.0051 17.1 0.0 0.023 14.9 0.0 2.0 1 1 1 2 2 2 1 MH2 domain zf-C3HC4_4 PF15227.6 KOH00435.1 - 0.0051 16.9 9.8 0.0051 16.9 9.8 2.2 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 KOH00435.1 - 0.069 13.0 5.6 0.22 11.4 5.6 1.9 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit ID PF18543.1 KOH00435.1 - 0.14 12.2 0.1 0.45 10.6 0.1 1.9 1 0 0 1 1 1 0 Intracellular delivery domain zf-RING_10 PF16685.5 KOH00435.1 - 5.3 7.3 12.8 0.034 14.3 3.2 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 KOH00435.1 - 8.3 6.4 20.2 0.023 14.6 8.1 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 NAD_binding_4 PF07993.12 KOH00436.1 - 1.1e-70 237.8 0.0 1.9e-70 237.0 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 KOH00436.1 - 3.8e-67 226.7 0.0 5.1e-67 226.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 KOH00436.1 - 2e-15 56.9 0.0 4.5e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 KOH00436.1 - 5.2e-09 35.9 0.0 9.6e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Condensation PF00668.20 KOH00436.1 - 3.4e-07 29.3 3.9 0.00011 21.0 3.9 2.2 1 1 0 1 1 1 1 Condensation domain 3Beta_HSD PF01073.19 KOH00436.1 - 1.1e-05 24.6 0.0 3.3e-05 23.0 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.6 KOH00436.1 - 9.5e-05 23.3 0.0 0.00032 21.6 0.0 2.0 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain GDP_Man_Dehyd PF16363.5 KOH00436.1 - 0.021 14.2 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Transketolase_N PF00456.21 KOH00437.1 - 2e-157 523.4 0.0 2.6e-157 523.0 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 KOH00437.1 - 2.3e-49 167.5 0.0 3.7e-49 166.8 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KOH00437.1 - 1.5e-11 44.3 0.0 3e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.21 KOH00437.1 - 0.00036 20.3 0.2 0.004 17.0 0.2 2.4 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.20 KOH00437.1 - 0.00038 19.5 0.0 0.0011 18.0 0.0 1.7 2 0 0 2 2 2 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 KOH00437.1 - 0.00057 19.2 0.1 0.002 17.4 0.1 1.8 1 1 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase XFP_C PF09363.10 KOH00437.1 - 0.027 13.9 0.0 0.058 12.9 0.0 1.4 1 0 0 1 1 1 0 XFP C-terminal domain ThiP_synth PF10120.9 KOH00437.1 - 0.035 13.7 0.0 0.13 11.9 0.0 1.8 2 0 0 2 2 2 0 Thiamine-phosphate synthase GTP_EFTU PF00009.27 KOH00438.1 - 4e-54 183.1 0.1 6.1e-54 182.5 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KOH00438.1 - 2.8e-40 137.1 0.0 6.6e-40 135.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KOH00438.1 - 3.1e-14 53.1 1.8 3.1e-14 53.1 1.8 2.6 4 0 0 4 4 4 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOH00438.1 - 0.00025 21.1 0.1 0.0064 16.6 0.2 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 KOH00438.1 - 0.14 12.1 4.7 0.062 13.2 0.9 2.2 2 0 0 2 2 2 0 Elongation factor Tu domain 4 RRM_1 PF00076.22 KOH00439.1 - 2.2e-11 43.4 0.0 1e-07 31.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOH00439.1 - 0.049 13.5 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Occluded RNA-recognition motif Nha1_C PF08619.10 KOH00439.1 - 0.13 11.5 5.6 0.17 11.1 5.6 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus CHD5 PF04420.14 KOH00439.1 - 0.23 11.3 6.4 0.096 12.5 3.4 1.8 1 1 1 2 2 2 0 CHD5-like protein HGTP_anticodon PF03129.20 KOH00441.1 - 1.4e-20 73.2 1.9 1.7e-20 73.0 0.1 2.1 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KOH00441.1 - 4.4e-07 30.0 0.0 1.9e-06 28.0 0.0 2.1 2 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) SPOUT_MTase PF02590.17 KOH00442.1 - 0.003 17.6 0.1 0.0043 17.0 0.1 1.3 1 0 0 1 1 1 1 Predicted SPOUT methyltransferase Ribosomal_L31 PF01197.18 KOH00442.1 - 0.0032 17.6 0.0 0.0057 16.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L31 Tau95 PF09734.9 KOH00443.1 - 4e-34 118.4 0.4 1.6e-33 116.5 0.6 1.9 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 KOH00443.1 - 1.9e-25 89.5 0.1 3.2e-25 88.8 0.1 1.4 1 0 0 1 1 1 1 Tau95 Triple barrel domain PP2C PF00481.21 KOH00444.1 - 3.4e-75 253.0 0.0 5.4e-71 239.2 0.0 2.1 1 1 1 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 KOH00444.1 - 0.0016 18.4 0.0 0.5 10.2 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KOH00444.1 - 0.11 12.1 0.0 0.48 10.0 0.0 2.1 1 1 0 1 1 1 0 Protein phosphatase 2C Glyco_transf_20 PF00982.21 KOH00445.1 - 4.6e-203 675.2 0.1 5.2e-203 675.0 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glycos_transf_1 PF00534.20 KOH00445.1 - 0.00059 19.4 2.0 0.053 13.1 0.1 3.5 3 1 0 3 3 3 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOH00445.1 - 0.00082 19.8 0.1 0.0025 18.2 0.0 1.9 2 1 0 2 2 2 1 Glycosyl transferases group 1 ATP-synt_ab PF00006.25 KOH00446.1 - 1.3e-66 224.3 0.0 1.9e-66 223.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KOH00446.1 - 4.6e-16 59.1 1.1 9.6e-16 58.1 1.1 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Atg14 PF10186.9 KOH00447.1 - 2.4e-28 99.2 4.4 3.3e-28 98.7 4.4 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Leu_zip PF15294.6 KOH00447.1 - 0.00095 18.8 6.8 0.0014 18.2 6.8 1.2 1 0 0 1 1 1 1 Leucine zipper Laminin_II PF06009.12 KOH00447.1 - 0.023 14.7 5.4 0.034 14.1 4.6 1.6 1 1 0 1 1 1 0 Laminin Domain II DUF4763 PF15960.5 KOH00447.1 - 0.032 13.5 5.2 0.023 14.0 3.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) TetR_C_4 PF08359.11 KOH00447.1 - 0.12 12.5 1.3 0.26 11.4 1.3 1.5 1 0 0 1 1 1 0 YsiA-like protein, C-terminal region VGPC1_C PF16799.5 KOH00447.1 - 0.38 10.8 5.0 0.27 11.2 1.4 2.5 3 0 0 3 3 3 0 C-terminal membrane-localisation domain of ion-channel, VCN1 Fib_alpha PF08702.10 KOH00447.1 - 0.62 10.2 12.4 0.22 11.7 4.7 2.8 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF724 PF05266.14 KOH00447.1 - 1.5 8.6 6.4 3.3 7.5 6.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) zf-C4pol PF14260.6 KOH00447.1 - 4.5 7.8 6.9 8.1 7.0 0.3 3.1 4 0 0 4 4 4 0 C4-type zinc-finger of DNA polymerase delta PH PF00169.29 KOH00448.1 - 1.2e-10 41.8 6.8 7.9e-08 32.8 1.4 2.7 2 1 0 2 2 2 2 PH domain PH_11 PF15413.6 KOH00448.1 - 0.012 16.0 8.3 1.3 9.5 0.1 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain SHE3 PF17078.5 KOH00449.1 - 8.9e-70 234.9 38.5 8.9e-70 234.9 38.5 2.0 2 0 0 2 2 2 1 SWI5-dependent HO expression protein 3 Spc7 PF08317.11 KOH00449.1 - 2.3 7.0 33.3 0.012 14.5 22.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF1712 PF08217.11 KOH00450.1 - 2.7e-204 680.1 19.3 3.1e-204 679.9 19.3 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) AA_permease PF00324.21 KOH00451.1 - 8.1e-140 466.6 25.1 9.2e-140 466.4 25.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOH00451.1 - 1.6e-26 93.1 27.4 2.1e-26 92.8 27.4 1.1 1 0 0 1 1 1 1 Amino acid permease PRMT5_TIM PF17285.2 KOH00452.1 - 7.8e-76 254.7 0.1 1.4e-75 253.8 0.1 1.4 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5_C PF17286.2 KOH00452.1 - 1.5e-64 217.1 0.5 2.9e-64 216.2 0.5 1.5 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5 PF05185.16 KOH00452.1 - 1.6e-59 200.6 0.0 2.7e-59 199.9 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase CKS PF01111.19 KOH00453.1 - 4e-35 119.9 0.2 6.4e-35 119.2 0.2 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit SUIM_assoc PF16619.5 KOH00453.1 - 0.00052 20.0 1.7 0.00068 19.6 1.7 1.3 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Med3 PF11593.8 KOH00453.1 - 7.5 5.6 16.7 9 5.4 16.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PI3_PI4_kinase PF00454.27 KOH00454.1 - 6.4e-59 199.8 1.5 2.4e-58 197.9 0.1 2.7 3 0 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.13 KOH00454.1 - 1.9e-28 98.3 0.4 3.6e-27 94.2 0.2 3.3 2 0 0 2 2 2 1 UME (NUC010) domain FATC PF02260.20 KOH00454.1 - 2.3e-14 52.9 0.1 4.6e-14 51.9 0.1 1.5 1 0 0 1 1 1 1 FATC domain FAT PF02259.23 KOH00454.1 - 1.3e-06 27.9 8.7 4.3e-06 26.2 6.3 2.6 2 0 0 2 2 2 1 FAT domain TPR_19 PF14559.6 KOH00454.1 - 0.06 13.9 0.3 0.34 11.4 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Lyase_8_N PF08124.11 KOH00454.1 - 0.073 12.0 4.9 1.8 7.4 0.1 3.7 4 0 0 4 4 4 0 Polysaccharide lyase family 8, N terminal alpha-helical domain Med27 PF11571.8 KOH00454.1 - 0.12 12.8 0.4 1.6 9.1 0.1 3.1 2 0 0 2 2 2 0 Mediator complex subunit 27 TPR_12 PF13424.6 KOH00454.1 - 0.14 12.5 0.0 0.54 10.6 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat Haem_degrading PF03928.14 KOH00455.1 - 3.1e-27 95.0 0.0 4e-27 94.6 0.0 1.1 1 0 0 1 1 1 1 Haem-degrading Cript PF10235.9 KOH00456.1 - 0.51 10.9 0.1 0.51 10.9 0.1 2.7 4 0 0 4 4 4 0 Microtubule-associated protein CRIPT KKLCAg1 PF15204.6 KOH00456.1 - 1.1 9.4 12.8 2.2 8.4 5.3 3.2 2 1 1 3 3 3 0 Kita-kyushu lung cancer antigen 1 Peptidase_S10 PF00450.22 KOH00457.1 - 4.9e-129 431.4 0.2 5.8e-129 431.2 0.2 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase RasGAP PF00616.19 KOH00458.1 - 3e-22 79.4 0.4 1.2e-11 44.8 0.1 3.1 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase DUF2717 PF10911.8 KOH00458.1 - 0.055 13.2 0.0 3.2 7.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2717) DUF1548 PF07579.11 KOH00458.1 - 1.7 9.0 6.5 0.85 10.0 0.0 3.9 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1548) Bmt2 PF11968.8 KOH00459.1 - 1.4e-73 247.4 0.0 2.1e-73 246.9 0.0 1.3 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 KOH00459.1 - 3.1e-06 27.1 0.0 9.6e-06 25.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOH00459.1 - 0.0013 19.5 0.0 0.065 14.0 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOH00459.1 - 0.0023 18.5 0.0 0.0064 17.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOH00459.1 - 0.0032 17.3 0.0 0.0077 16.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOH00459.1 - 0.014 16.1 0.0 0.043 14.5 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain CheR PF01739.18 KOH00459.1 - 0.016 14.7 0.1 0.053 13.0 0.0 1.8 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain NodS PF05401.11 KOH00459.1 - 0.068 12.8 0.0 0.18 11.4 0.0 1.7 2 0 0 2 2 2 0 Nodulation protein S (NodS) DEAD PF00270.29 KOH00460.1 - 3.7e-40 137.5 0.2 7.1e-40 136.6 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOH00460.1 - 2.6e-33 114.7 1.6 2.2e-29 102.0 0.1 3.1 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 KOH00460.1 - 4.6e-08 33.2 0.4 4.6e-08 33.2 0.4 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit SDA1 PF05285.12 KOH00460.1 - 0.0055 16.2 14.6 0.0055 16.2 14.6 2.4 2 0 0 2 2 2 1 SDA1 UPF0524 PF15823.5 KOH00460.1 - 1.6 8.1 7.5 3.6 6.9 7.5 1.5 1 0 0 1 1 1 0 UPF0524 of C3orf70 BIRC6 PF12356.8 KOH00460.1 - 3.6 7.0 11.8 0.52 9.7 6.1 2.4 1 1 1 2 2 2 0 Baculoviral IAP repeat-containing protein 6 eRF1_2 PF03464.15 KOH00461.1 - 7.7e-46 155.7 0.0 1.6e-45 154.7 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 KOH00461.1 - 7.5e-38 129.5 0.2 1.7e-37 128.4 0.2 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 KOH00461.1 - 3.8e-19 69.0 0.0 6.3e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 KOH00461.1 - 2.6e-10 40.7 0.0 4.1e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 KOH00461.1 - 1.6e-08 34.9 0.0 2.8e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 PTSIIB_sorb PF03830.15 KOH00461.1 - 0.19 11.9 0.7 1.1 9.5 0.1 2.3 2 1 1 3 3 3 0 PTS system sorbose subfamily IIB component ADH_N PF08240.12 KOH00462.1 - 1.2e-29 102.4 1.1 1.2e-29 102.4 1.1 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOH00462.1 - 5.3e-26 91.1 0.5 7.5e-26 90.6 0.5 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOH00462.1 - 1.6e-05 26.0 0.0 2.7e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 KOH00462.1 - 0.07 12.6 0.2 0.12 11.9 0.2 1.3 1 0 0 1 1 1 0 short chain dehydrogenase NqrM PF04400.13 KOH00462.1 - 0.1 12.4 0.2 0.1 12.4 0.2 2.2 2 0 0 2 2 2 0 (Na+)-NQR maturation NqrM Ribosomal_S9 PF00380.19 KOH00463.1 - 1.6e-41 141.6 0.3 2.4e-41 141.0 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S9/S16 PQ-loop PF04193.14 KOH00464.1 - 1.5e-41 140.0 10.9 1.4e-23 82.4 2.4 3.1 4 0 0 4 4 4 2 PQ loop repeat Steroid_dh PF02544.16 KOH00464.1 - 0.02 14.9 0.8 0.065 13.2 0.1 2.1 2 0 0 2 2 2 0 3-oxo-5-alpha-steroid 4-dehydrogenase MtN3_slv PF03083.16 KOH00464.1 - 1.3 9.1 8.8 1.5 8.9 0.8 3.4 2 1 1 3 3 3 0 Sugar efflux transporter for intercellular exchange DUF4191 PF13829.6 KOH00465.1 - 0.00023 20.6 2.1 0.00023 20.6 2.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4191) HALZ PF02183.18 KOH00465.1 - 5 7.4 13.1 0.37 11.1 3.5 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper Aldo_ket_red PF00248.21 KOH00466.1 - 1.3e-38 132.9 0.0 4.8e-37 127.7 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Fungal_trans PF04082.18 KOH00467.1 - 8.3e-30 103.7 4.9 2.7e-29 102.0 4.9 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOH00467.1 - 1.1e-08 35.1 11.2 2e-08 34.2 11.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RNA_pol_3_Rpc31 PF11705.8 KOH00467.1 - 0.0032 17.8 24.7 0.0032 17.8 24.7 2.2 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 CRS1_YhbY PF01985.21 KOH00467.1 - 0.07 13.3 0.3 0.17 12.1 0.3 1.6 1 0 0 1 1 1 0 CRS1 / YhbY (CRM) domain CobT PF06213.12 KOH00467.1 - 0.17 11.2 19.9 0.32 10.3 19.9 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 KOH00467.1 - 0.4 8.9 18.8 0.86 7.8 18.8 1.6 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 KOH00467.1 - 3.9 6.6 9.3 9.3 5.4 9.3 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter DNA_pol_phi PF04931.13 KOH00467.1 - 4.9 5.1 45.1 5.2 5.0 42.9 1.9 2 0 0 2 2 2 0 DNA polymerase phi Astro_capsid_p PF12226.8 KOH00467.1 - 7 5.7 19.9 14 4.7 19.9 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein SDA1 PF05285.12 KOH00467.1 - 7.5 5.9 36.7 0.1 12.0 26.6 2.5 3 0 0 3 3 3 0 SDA1 Suc_Fer-like PF06999.12 KOH00468.1 - 1.3e-47 162.2 0.0 1.6e-47 162.0 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like DUF4679 PF15728.5 KOH00468.1 - 0.08 12.0 0.2 0.24 10.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4679) MFAP1 PF06991.11 KOH00469.1 - 4.9e-05 23.3 18.7 4.9e-05 23.3 18.7 2.9 1 1 2 3 3 3 1 Microfibril-associated/Pre-mRNA processing RibD_C PF01872.17 KOH00470.1 - 1.6e-39 135.9 0.0 1.8e-39 135.7 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain RNA_pol_Rpb5_C PF01191.19 KOH00471.1 - 5.3e-31 106.3 0.2 1.1e-30 105.3 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 KOH00471.1 - 6.9e-29 100.3 0.2 1.2e-28 99.5 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 KOH00471.1 - 0.022 14.8 0.0 0.066 13.2 0.0 1.7 2 0 0 2 2 2 0 Restriction endonuclease TPR_1 PF00515.28 KOH00472.1 - 1.1e-09 37.6 6.0 5.2e-06 26.0 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOH00472.1 - 7.7e-09 35.0 4.7 0.0051 16.8 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOH00472.1 - 0.00042 20.5 3.1 0.00096 19.3 2.7 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KOH00472.1 - 0.0046 17.2 0.6 3.2 8.1 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOH00472.1 - 0.027 14.7 9.8 0.53 10.6 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 KOH00472.1 - 0.028 14.1 0.6 4.4 7.1 0.0 2.9 2 1 0 2 2 2 0 TPR repeat LRR_4 PF12799.7 KOH00474.1 - 0.0002 21.7 16.6 0.054 13.9 2.8 4.6 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOH00474.1 - 0.012 15.6 10.5 0.033 14.2 0.1 4.7 6 0 0 6 6 6 0 Leucine Rich repeat LRR_8 PF13855.6 KOH00474.1 - 1.1 9.1 7.7 0.17 11.7 0.9 3.3 3 1 0 3 3 3 0 Leucine rich repeat LRR_1 PF00560.33 KOH00474.1 - 2.2 9.2 8.8 21 6.2 0.1 5.0 3 1 1 4 4 4 0 Leucine Rich Repeat adh_short PF00106.25 KOH00475.1 - 1.3e-34 119.4 0.0 1.8e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOH00475.1 - 4.3e-21 75.5 0.0 5.5e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOH00475.1 - 9.6e-08 32.1 0.1 2.7e-07 30.7 0.0 1.7 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 KOH00475.1 - 0.001 18.3 0.2 0.0015 17.7 0.2 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 KOH00475.1 - 0.0067 16.7 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 KOH00475.1 - 0.011 15.6 0.0 0.025 14.5 0.0 1.6 2 0 0 2 2 2 0 NAD(P)H-binding 3HCDH_N PF02737.18 KOH00475.1 - 0.076 12.9 0.3 0.15 11.9 0.3 1.5 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain T_Ag_DNA_bind PF02217.16 KOH00475.1 - 0.12 13.0 0.6 0.45 11.1 0.1 2.1 2 0 0 2 2 2 0 Origin of replication binding protein AP_endonuc_2 PF01261.24 KOH00475.1 - 0.18 11.2 0.0 0.26 10.7 0.0 1.2 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Pkinase PF00069.25 KOH00476.1 - 6e-71 238.9 0.0 6.9e-71 238.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00476.1 - 5.9e-33 114.3 0.0 7.3e-33 113.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOH00476.1 - 2.7e-05 23.7 0.0 4.4e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOH00476.1 - 0.0027 17.7 0.2 0.04 13.8 0.1 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOH00476.1 - 0.0044 16.0 0.0 0.014 14.3 0.0 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOH00476.1 - 0.04 13.3 0.2 0.18 11.1 0.2 1.9 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 KOH00476.1 - 0.1 11.6 0.1 0.16 11.0 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Gly_transf_sug PF04488.15 KOH00477.1 - 1.9e-21 76.5 0.1 6.9e-21 74.7 0.1 2.0 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif DUF2401 PF10287.9 KOH00478.1 - 7.7e-93 310.3 1.0 7.7e-93 310.3 1.0 2.0 3 0 0 3 3 3 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 KOH00478.1 - 1.7e-27 95.6 0.1 4.8e-27 94.2 0.1 1.8 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) Macoilin PF09726.9 KOH00478.1 - 3.9 5.9 7.5 5.1 5.5 7.5 1.1 1 0 0 1 1 1 0 Macoilin family RAMP4 PF06624.12 KOH00479.1 - 1e-11 44.7 0.1 1.3e-11 44.4 0.1 1.1 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Exo5 PF09810.9 KOH00480.1 - 4.1e-56 191.0 1.9 5.8e-56 190.6 1.9 1.1 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 KOH00480.1 - 0.00013 22.0 2.5 0.033 14.1 1.9 3.1 2 1 0 2 2 2 1 PD-(D/E)XK nuclease superfamily DUF3496 PF12001.8 KOH00480.1 - 0.21 12.0 0.2 0.21 12.0 0.2 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3496) Arf PF00025.21 KOH00481.1 - 1.2e-76 256.0 0.1 1.4e-76 255.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KOH00481.1 - 1.6e-15 57.4 0.0 2.1e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KOH00481.1 - 2.6e-11 43.3 0.0 3.2e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 KOH00481.1 - 6.9e-11 42.0 0.0 7.9e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 KOH00481.1 - 3.8e-10 39.5 0.3 4.8e-06 26.0 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KOH00481.1 - 1.2e-09 37.8 0.0 1.6e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOH00481.1 - 0.00014 21.5 0.1 0.0012 18.5 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOH00481.1 - 0.00017 21.6 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 KOH00481.1 - 0.0015 19.0 0.3 0.0055 17.2 0.3 1.7 1 1 0 1 1 1 1 ABC transporter MeaB PF03308.16 KOH00481.1 - 0.0047 15.9 0.6 0.19 10.7 0.2 2.6 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 KOH00481.1 - 0.041 14.4 0.1 0.095 13.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 KOH00481.1 - 0.11 12.0 0.9 9 5.8 0.2 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 KOH00481.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain PDH PF02153.17 KOH00483.1 - 7.1e-11 41.6 0.0 1e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase NAD_binding_2 PF03446.15 KOH00483.1 - 4.3e-05 23.7 0.0 7.6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 KOH00483.1 - 8.5e-05 23.1 0.0 0.00017 22.1 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 KOH00483.1 - 0.00013 21.6 0.0 0.00025 20.7 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 KOH00483.1 - 0.00016 21.1 0.0 0.0004 19.8 0.0 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 KOH00483.1 - 0.0071 16.3 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.12 KOH00483.1 - 0.028 14.0 0.0 0.052 13.1 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_N PF03721.14 KOH00483.1 - 0.041 13.5 0.0 0.071 12.7 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 KOH00483.1 - 0.1 12.7 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Rpp20 PF12328.8 KOH00484.1 - 1.6e-28 99.3 5.0 3.6e-26 91.8 5.0 2.2 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 KOH00484.1 - 1.7e-10 40.6 0.2 2.8e-10 39.8 0.2 1.3 1 0 0 1 1 1 1 Alba Pex24p PF06398.11 KOH00485.1 - 8.6e-62 209.2 16.4 1e-61 209.0 16.4 1.0 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Cleaved_Adhesin PF07675.11 KOH00485.1 - 0.019 14.9 1.6 0.032 14.2 1.6 1.3 1 0 0 1 1 1 0 Cleaved Adhesin Domain HSP70 PF00012.20 KOH00486.1 - 4.6e-188 626.2 0.0 6.2e-188 625.7 0.0 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOH00486.1 - 1.3e-09 37.3 0.0 4.8e-09 35.5 0.0 1.7 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 KOH00486.1 - 0.004 17.5 2.6 0.032 14.7 0.1 3.2 3 2 0 3 3 3 1 Cell division protein FtsA CT_C_D PF02682.16 KOH00486.1 - 0.015 15.0 0.2 0.061 13.1 0.0 2.0 2 0 0 2 2 2 0 Carboxyltransferase domain, subdomain C and D NLE PF08154.12 KOH00486.1 - 0.03 14.9 0.1 0.14 12.7 0.1 2.2 1 0 0 1 1 1 0 NLE (NUC135) domain Mod_r PF07200.13 KOH00486.1 - 3.4 7.8 9.7 0.052 13.6 1.0 2.3 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein NPL4 PF05021.15 KOH00487.1 - 2.6e-139 463.8 0.1 3.6e-139 463.4 0.1 1.2 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 KOH00487.1 - 8e-70 233.6 2.1 1.2e-69 233.1 2.1 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 KOH00487.1 - 4.9e-05 23.7 0.0 0.00016 22.1 0.0 2.0 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 Sec66 PF09802.9 KOH00488.1 - 3.9e-70 235.1 2.4 4.6e-70 234.9 2.4 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 TMEM154 PF15102.6 KOH00488.1 - 0.023 14.6 0.1 0.035 14.0 0.1 1.2 1 0 0 1 1 1 0 TMEM154 protein family GYF PF02213.16 KOH00489.1 - 2.1e-16 59.3 0.1 4.2e-16 58.3 0.1 1.6 1 0 0 1 1 1 1 GYF domain UMP1 PF05348.11 KOH00490.1 - 8.9e-43 145.3 0.2 1.1e-42 145.0 0.2 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 WD40 PF00400.32 KOH00491.1 - 1.5e-24 85.8 9.4 5.1e-07 30.3 0.0 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00491.1 - 5.2e-19 68.3 0.0 7.6e-06 26.2 0.0 5.8 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOH00491.1 - 2.4e-05 23.2 0.0 0.044 12.4 0.1 2.6 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 KOH00491.1 - 3e-05 22.7 0.1 0.013 14.1 0.0 2.7 2 1 1 3 3 3 2 Cytochrome D1 heme domain eIF2A PF08662.11 KOH00491.1 - 0.0097 15.8 0.1 4.9 7.0 0.0 3.6 2 1 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 KOH00491.1 - 0.023 14.6 0.0 8.8 6.4 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 KOH00491.1 - 0.13 11.5 0.3 1.2 8.4 0.0 2.4 3 0 0 3 3 3 0 WD40-like domain DPPIV_N PF00930.21 KOH00491.1 - 0.17 10.6 0.0 1.2 7.8 0.0 2.3 2 1 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pantoate_transf PF02548.15 KOH00492.1 - 5.1e-95 317.7 0.0 6e-95 317.5 0.0 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 KOH00492.1 - 0.002 17.6 0.0 0.004 16.6 0.0 1.5 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Peptidase_S41_N PF11918.8 KOH00492.1 - 0.023 14.9 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP Asp_Glu_race PF01177.22 KOH00492.1 - 0.072 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Asp/Glu/Hydantoin racemase Abhydrolase_1 PF00561.20 KOH00493.1 - 1.5e-28 100.1 0.0 3.1e-28 99.1 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOH00493.1 - 2.7e-11 43.2 0.0 5e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KOH00493.1 - 3.9e-05 23.2 0.0 0.0046 16.5 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family ORC3_N PF07034.11 KOH00493.1 - 0.0028 16.8 0.0 0.0042 16.2 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus Phage_TAC_9 PF10876.8 KOH00493.1 - 0.062 13.4 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Phage tail assemb.y chaperone protein, TAC Dynamin_N PF00350.23 KOH00494.1 - 8.5e-15 55.2 0.9 3.8e-14 53.1 0.1 2.4 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 KOH00494.1 - 1.2e-09 38.3 0.0 1e-08 35.3 0.0 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOH00494.1 - 8.1e-08 32.0 0.4 3.6e-05 23.4 0.4 2.6 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 KOH00494.1 - 0.01 15.6 0.4 9.5 6.0 0.0 3.4 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 KOH00494.1 - 0.072 12.7 0.3 0.54 9.8 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF1640 PF07798.11 KOH00494.1 - 1.1 9.2 7.5 0.098 12.7 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1640) MFS_1 PF07690.16 KOH00495.1 - 3.7e-49 167.5 40.5 1.6e-44 152.3 18.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOH00495.1 - 1.7e-19 70.0 21.5 4.4e-17 62.1 2.0 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_4 PF06779.14 KOH00495.1 - 4.1e-05 23.0 9.2 4.1e-05 23.0 9.2 1.9 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Ribosomal_S6e PF01092.19 KOH00496.1 - 3.3e-22 78.8 0.8 5.2e-22 78.1 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein S6e SRF-TF PF00319.18 KOH00497.1 - 7.8e-22 76.5 0.1 1.6e-21 75.5 0.1 1.6 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Ceramidase PF05875.12 KOH00498.1 - 3.1e-89 298.9 13.7 3.5e-89 298.7 13.7 1.0 1 0 0 1 1 1 1 Ceramidase DUF981 PF06168.11 KOH00498.1 - 0.024 14.6 0.2 0.024 14.6 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF981) SLATT_4 PF18186.1 KOH00498.1 - 0.044 13.4 0.6 0.089 12.4 0.6 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 Leader_Trp PF08255.11 KOH00498.1 - 0.11 12.5 2.1 0.41 10.7 2.1 2.0 1 0 0 1 1 1 0 Trp-operon Leader Peptide FeoB_associated PF12669.7 KOH00498.1 - 7 7.1 7.6 32 5.0 1.1 3.4 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein MBA1 PF07961.11 KOH00500.1 - 7.8e-108 358.9 1.4 1.1e-107 358.5 1.4 1.2 1 0 0 1 1 1 1 MBA1-like protein SspN PF08177.11 KOH00500.1 - 0.15 12.0 0.1 0.3 11.1 0.1 1.4 1 0 0 1 1 1 0 Small acid-soluble spore protein N family UPF0016 PF01169.19 KOH00502.1 - 3.5e-38 129.8 31.7 2.3e-20 72.7 9.9 2.5 3 0 0 3 3 3 2 Uncharacterized protein family UPF0016 DUF4148 PF13663.6 KOH00502.1 - 2.8 8.2 5.1 8.1 6.7 0.8 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) cwf18 PF08315.12 KOH00503.1 - 4.9e-07 30.5 4.6 2.4e-06 28.3 4.6 1.9 1 1 0 1 1 1 1 cwf18 pre-mRNA splicing factor DUF1492 PF07374.11 KOH00503.1 - 0.072 13.3 0.2 0.13 12.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) Cep57_CLD_2 PF14197.6 KOH00503.1 - 0.14 12.3 7.1 3.9 7.6 0.4 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 RP-C_C PF11800.8 KOH00503.1 - 0.31 11.1 2.6 2.6 8.1 0.2 1.9 1 1 1 2 2 2 0 Replication protein C C-terminal region FeoB_Cyto PF17910.1 KOH00503.1 - 0.64 10.6 3.5 1.2 9.7 2.3 2.1 2 1 0 2 2 2 0 FeoB cytosolic helical domain Ribosomal_L21e PF01157.18 KOH00505.1 - 5.3e-48 161.0 5.7 5.3e-48 161.0 5.7 1.8 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.9 KOH00505.1 - 0.026 14.1 0.0 0.032 13.8 0.0 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Mito_carr PF00153.27 KOH00506.1 - 8.7e-76 250.0 3.0 6.1e-28 96.6 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Med8 PF10232.9 KOH00507.1 - 8e-17 61.6 2.6 9.5e-17 61.4 2.6 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 ArAE_2 PF10334.9 KOH00507.1 - 0.053 13.3 0.0 0.084 12.7 0.0 1.3 1 0 0 1 1 1 0 Aromatic acid exporter family member 2 NpwBP PF12622.7 KOH00508.1 - 1.2e-09 38.8 0.1 2.9e-09 37.5 0.1 1.7 1 0 0 1 1 1 1 mRNA biogenesis factor DivIC PF04977.15 KOH00508.1 - 0.13 12.0 4.2 0.22 11.3 4.2 1.3 1 0 0 1 1 1 0 Septum formation initiator CAF1C_H4-bd PF12265.8 KOH00509.1 - 3.1e-19 69.0 1.1 1e-18 67.4 1.1 1.9 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 KOH00509.1 - 1.1e-14 54.5 11.8 0.0021 18.9 0.9 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00509.1 - 9.5e-10 38.7 2.3 0.027 14.8 0.0 4.7 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOH00509.1 - 3.9e-07 30.1 1.1 0.00035 20.5 0.1 3.3 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOH00509.1 - 0.025 13.6 0.1 2.1 7.2 0.0 3.3 1 1 3 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 KOH00509.1 - 0.027 12.5 1.0 0.49 8.3 0.1 2.1 2 0 0 2 2 2 0 IKI3 family SUKH_6 PF14568.6 KOH00509.1 - 0.038 14.4 0.1 16 5.9 0.0 3.4 1 1 1 2 2 2 0 SMI1-KNR4 cell-wall SdiA-regulated PF06977.11 KOH00509.1 - 0.056 12.7 0.1 9.6 5.3 0.0 2.6 2 1 0 2 2 2 0 SdiA-regulated PGI PF00342.19 KOH00510.1 - 3.5e-248 824.0 2.7 4.1e-248 823.8 2.7 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase DUF5315 PF17242.2 KOH00511.1 - 8.2e-21 73.6 0.2 1.3e-20 73.0 0.2 1.3 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) TRF PF08558.10 KOH00511.1 - 0.03 13.9 0.2 0.043 13.4 0.2 1.1 1 0 0 1 1 1 0 Telomere repeat binding factor (TRF) WD40 PF00400.32 KOH00512.1 - 1.8e-51 170.9 20.5 1.2e-09 38.7 0.3 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 KOH00512.1 - 3e-43 147.2 1.3 5.9e-43 146.2 1.3 1.4 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 KOH00512.1 - 5.4e-13 49.1 0.0 0.011 16.0 0.0 6.0 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOH00512.1 - 4.9e-07 29.4 0.0 0.81 9.0 0.0 3.7 2 1 2 4 4 4 3 WD40-like domain LisH PF08513.11 KOH00512.1 - 7.9e-07 28.8 0.1 2.1e-06 27.4 0.1 1.8 1 0 0 1 1 1 1 LisH Ge1_WD40 PF16529.5 KOH00512.1 - 0.00021 20.3 0.0 0.2 10.6 0.0 3.6 2 2 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 KOH00512.1 - 0.0023 16.8 0.3 0.079 11.7 0.3 3.0 1 1 0 1 1 1 1 Nup133 N terminal like Nup160 PF11715.8 KOH00512.1 - 0.0031 16.3 1.0 3 6.4 0.1 3.4 3 1 0 3 3 3 2 Nucleoporin Nup120/160 PD40 PF07676.12 KOH00512.1 - 0.017 15.0 0.0 3.5 7.7 0.0 3.1 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 KOH00512.1 - 0.031 12.8 0.1 0.16 10.5 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain Glyco_transf_15 PF01793.16 KOH00513.1 - 9.3e-105 350.5 10.9 1.2e-104 350.1 10.9 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF3326 PF11805.8 KOH00513.1 - 0.033 13.1 0.0 0.093 11.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3326) CsgA PF17334.2 KOH00513.1 - 0.039 14.7 0.4 0.13 13.0 0.4 1.9 1 0 0 1 1 1 0 Minor curli fiber component A MSC PF09402.10 KOH00513.1 - 0.12 11.8 0.0 4.4 6.7 0.0 2.4 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain UvrD-helicase PF00580.21 KOH00513.1 - 0.16 11.4 0.3 0.85 9.1 0.1 2.1 1 1 1 3 3 3 0 UvrD/REP helicase N-terminal domain SH3_1 PF00018.28 KOH00514.1 - 1.5e-24 85.3 0.0 6.6e-11 41.6 0.1 2.7 2 0 0 2 2 2 2 SH3 domain PX PF00787.24 KOH00514.1 - 2.2e-17 63.1 0.0 4.3e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 PX domain SH3_9 PF14604.6 KOH00514.1 - 3.2e-14 52.5 0.5 2.7e-10 39.9 0.0 2.8 3 0 0 3 3 3 2 Variant SH3 domain SH3_2 PF07653.17 KOH00514.1 - 7.1e-08 32.0 0.1 3.4e-07 29.8 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain PB1 PF00564.24 KOH00514.1 - 1.2e-05 25.1 0.1 3.2e-05 23.8 0.1 1.7 1 0 0 1 1 1 1 PB1 domain USP7_ICP0_bdg PF12436.8 KOH00514.1 - 0.01 15.1 0.1 0.019 14.3 0.1 1.3 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 DER1 PF04511.15 KOH00515.1 - 1.1e-54 185.3 8.2 1.2e-54 185.1 8.2 1.0 1 0 0 1 1 1 1 Der1-like family RVT_1 PF00078.27 KOH00515.1 - 0.055 13.0 0.0 0.077 12.5 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) COX7C PF02935.16 KOH00516.1 - 0.054 13.8 0.1 0.081 13.2 0.1 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIc DUF4668 PF15701.5 KOH00516.1 - 0.098 12.5 0.0 0.098 12.5 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) MCM PF00493.23 KOH00517.1 - 9.3e-103 342.1 0.0 1.5e-102 341.5 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KOH00517.1 - 2.4e-31 108.2 0.5 4.1e-31 107.4 0.5 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KOH00517.1 - 2e-22 79.4 1.0 2e-22 79.4 1.0 2.0 2 0 0 2 2 1 1 MCM AAA-lid domain MCM_N PF14551.6 KOH00517.1 - 2e-13 50.8 6.2 1.2e-12 48.4 6.2 2.4 1 1 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 KOH00517.1 - 7e-08 32.1 0.0 1.1e-05 24.9 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOH00517.1 - 1.9e-06 27.9 0.0 9e-06 25.7 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF455 PF04305.14 KOH00517.1 - 0.0025 17.4 0.1 0.0048 16.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF455) Mg_chelatase_C PF13335.6 KOH00517.1 - 0.011 16.3 0.3 0.077 13.6 0.2 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal AAA_lid_2 PF17863.1 KOH00517.1 - 0.013 15.3 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA lid domain Sigma54_activat PF00158.26 KOH00517.1 - 0.037 13.7 0.0 0.55 9.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.11 KOH00517.1 - 0.043 13.7 0.0 0.14 12.0 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOH00517.1 - 0.17 12.3 0.9 3.2 8.1 0.0 3.0 2 1 0 3 3 3 0 AAA ATPase domain AAA PF00004.29 KOH00517.1 - 0.84 10.1 3.6 0.66 10.4 0.1 2.6 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) F-box-like PF12937.7 KOH00518.1 - 0.00025 20.9 0.0 0.00056 19.7 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOH00518.1 - 0.00036 20.3 0.0 0.0015 18.4 0.0 2.1 1 0 0 1 1 1 1 F-box domain Abhydrolase_1 PF00561.20 KOH00519.1 - 4.7e-32 111.7 0.0 6e-32 111.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOH00519.1 - 6.5e-17 62.9 0.0 8.4e-17 62.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOH00519.1 - 1.6e-07 30.8 0.0 4.5e-07 29.4 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 KOH00519.1 - 1e-05 25.3 0.0 1.9e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase PGAP1 PF07819.13 KOH00519.1 - 0.00014 21.7 0.0 0.0097 15.6 0.0 2.2 2 0 0 2 2 2 1 PGAP1-like protein Ser_hydrolase PF06821.13 KOH00519.1 - 0.0016 18.4 0.0 0.0027 17.6 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase Thioesterase PF00975.20 KOH00519.1 - 0.12 12.4 0.0 6.1 6.9 0.0 2.2 2 0 0 2 2 2 0 Thioesterase domain Glyco_transf_15 PF01793.16 KOH00520.1 - 5.4e-126 420.2 9.2 6.5e-126 420.0 9.2 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase FTR1 PF03239.14 KOH00521.1 - 3.5e-113 377.8 1.9 4.1e-113 377.6 1.9 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Amidase_5 PF05382.13 KOH00521.1 - 0.017 15.0 1.1 0.023 14.6 0.2 1.6 2 0 0 2 2 2 0 Bacteriophage peptidoglycan hydrolase S_2TMBeta PF18153.1 KOH00521.1 - 0.11 12.2 3.7 0.088 12.6 0.7 2.3 2 0 0 2 2 2 0 SMODS-associating 2TM, beta-strand rich effector domain DUF3149 PF11346.8 KOH00521.1 - 0.65 9.7 6.8 0.14 11.8 1.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) Amidase PF01425.21 KOH00522.1 - 1.4e-104 350.6 0.0 1.9e-104 350.1 0.0 1.2 1 0 0 1 1 1 1 Amidase CT_A_B PF02626.15 KOH00522.1 - 1.4e-85 287.1 0.0 2.4e-85 286.3 0.0 1.4 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 KOH00522.1 - 1.6e-63 214.0 0.0 3e-63 213.1 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CT_C_D PF02682.16 KOH00522.1 - 4.8e-44 150.5 0.0 1e-43 149.5 0.0 1.5 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_carb_N PF00289.22 KOH00522.1 - 7.2e-42 142.4 0.0 1.8e-41 141.1 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KOH00522.1 - 1.6e-32 111.8 0.0 5.2e-32 110.1 0.0 1.9 2 0 0 2 2 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 KOH00522.1 - 1.9e-17 62.9 0.3 5.3e-17 61.4 0.3 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 KOH00522.1 - 2e-12 47.1 0.0 4.9e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KOH00522.1 - 6.4e-06 25.8 0.1 1.9e-05 24.3 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_3 PF02655.14 KOH00522.1 - 0.00043 20.4 0.0 0.00084 19.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.6 KOH00522.1 - 0.0058 16.1 0.0 0.017 14.5 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain RnfC_N PF13375.6 KOH00522.1 - 0.032 14.2 0.0 0.082 12.9 0.0 1.7 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain ATPgrasp_Ter PF15632.6 KOH00522.1 - 0.056 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Cornichon PF03311.14 KOH00523.1 - 1.9e-39 134.8 10.7 2.2e-39 134.5 10.7 1.0 1 0 0 1 1 1 1 Cornichon protein DivIC PF04977.15 KOH00524.1 - 0.19 11.5 5.1 0.3 10.9 3.7 2.1 1 1 1 2 2 2 0 Septum formation initiator APG6_N PF17675.1 KOH00524.1 - 1.5 9.3 10.9 0.17 12.4 5.6 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region RRM_1 PF00076.22 KOH00525.1 - 5e-44 148.0 0.0 1.7e-16 59.8 0.0 4.3 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KOH00525.1 - 4.6e-05 23.3 0.0 0.0011 18.9 0.0 2.6 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif SUIM_assoc PF16619.5 KOH00525.1 - 0.0036 17.3 14.9 0.1 12.7 2.1 2.9 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 RRM_7 PF16367.5 KOH00525.1 - 0.031 14.4 0.1 0.41 10.8 0.0 2.8 3 0 0 3 3 3 0 RNA recognition motif RRM_3 PF08777.11 KOH00525.1 - 0.55 10.3 0.0 0.55 10.3 0.0 2.8 4 1 0 4 4 4 0 RNA binding motif NAD_binding_7 PF13241.6 KOH00526.1 - 3.8e-27 94.8 0.0 6.2e-27 94.1 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 KOH00526.1 - 2e-16 59.4 0.0 4.4e-16 58.3 0.0 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 KOH00526.1 - 1.3e-10 40.5 0.0 2.5e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Shikimate_DH PF01488.20 KOH00526.1 - 0.12 12.4 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CBS PF00571.28 KOH00527.1 - 7.3e-20 71.2 1.6 2.7e-06 27.7 0.0 5.4 5 0 0 5 5 5 5 CBS domain HUN PF08729.10 KOH00528.1 - 3.3e-07 30.2 0.0 3.3e-07 30.2 0.0 2.3 2 0 0 2 2 2 1 HPC2 and ubinuclein domain FRP PF18032.1 KOH00528.1 - 0.028 15.0 0.1 0.076 13.6 0.1 1.8 1 0 0 1 1 1 0 Photoprotection regulator fluorescence recovery protein Kinetochor_Ybp2 PF08568.10 KOH00529.1 - 2e-152 509.0 16.1 2.3e-152 508.7 16.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin APG12 PF04110.13 KOH00530.1 - 2.8e-32 111.0 0.2 5.4e-32 110.0 0.2 1.5 2 0 0 2 2 2 1 Ubiquitin-like autophagy protein Apg12 GcrA PF07750.11 KOH00530.1 - 0.042 14.2 0.3 0.058 13.8 0.3 1.3 1 0 0 1 1 1 0 GcrA cell cycle regulator BPL_N PF09825.9 KOH00530.1 - 0.061 12.4 2.0 0.066 12.3 2.0 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF4471 PF14740.6 KOH00530.1 - 0.11 11.7 3.6 0.14 11.4 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) Presenilin PF01080.17 KOH00530.1 - 0.34 9.6 4.3 0.41 9.3 4.3 1.2 1 0 0 1 1 1 0 Presenilin CPSase_L_D2 PF02786.17 KOH00531.1 - 7.6e-84 280.4 0.0 1.3e-83 279.6 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 KOH00531.1 - 2.7e-68 229.6 0.0 4.2e-68 229.0 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 KOH00531.1 - 2.4e-38 131.1 0.1 5.8e-38 129.8 0.1 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KOH00531.1 - 3.1e-31 107.6 0.0 8.8e-31 106.2 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 KOH00531.1 - 2.9e-28 99.2 0.1 5.9e-28 98.1 0.1 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 KOH00531.1 - 7.1e-19 67.4 5.8 7.1e-19 67.4 5.8 2.4 3 0 0 3 3 3 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 KOH00531.1 - 3.9e-07 29.8 2.8 0.0017 18.1 0.2 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 KOH00531.1 - 2e-06 27.5 0.0 4.3e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KOH00531.1 - 2.2e-06 27.3 0.0 4.5e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 KOH00531.1 - 7.1e-05 22.9 0.0 0.0002 21.4 0.0 1.9 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 KOH00531.1 - 0.00011 21.5 0.8 0.0026 17.0 0.3 2.5 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATPgrasp_ST PF14397.6 KOH00531.1 - 0.0046 16.2 0.0 0.013 14.8 0.0 1.7 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp RnfC_N PF13375.6 KOH00531.1 - 0.013 15.4 4.1 0.22 11.5 2.3 2.8 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain HlyD_3 PF13437.6 KOH00531.1 - 0.016 15.9 4.3 5.7 7.7 0.1 4.0 5 0 0 5 5 4 0 HlyD family secretion protein ATP-grasp_4 PF13535.6 KOH00531.1 - 0.025 14.2 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain GCV_H PF01597.19 KOH00531.1 - 0.1 12.5 0.7 0.25 11.3 0.7 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein Acatn PF13000.7 KOH00532.1 - 6.2e-281 932.7 14.2 7e-281 932.5 14.2 1.0 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Transket_pyr PF02779.24 KOH00533.1 - 9.6e-48 162.2 0.0 3.7e-47 160.3 0.0 1.8 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KOH00533.1 - 3.3e-37 127.1 0.1 6.2e-37 126.2 0.1 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain GntR PF00392.21 KOH00533.1 - 0.044 13.4 0.5 5.3 6.8 0.1 2.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family AMP-binding PF00501.28 KOH00534.1 - 1.5e-71 241.2 0.0 2.3e-71 240.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOH00534.1 - 2.6e-19 70.0 0.2 6.5e-19 68.7 0.1 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain NSP11 PF06471.12 KOH00534.1 - 0.061 11.8 0.1 0.17 10.3 0.0 1.7 2 0 0 2 2 2 0 NSP11 Tyr-DNA_phospho PF06087.12 KOH00535.1 - 4.4e-96 322.4 0.1 5.4e-96 322.1 0.1 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 KOH00535.1 - 0.0077 16.1 0.0 0.084 12.8 0.0 2.3 2 0 0 2 2 2 1 PLD-like domain Methyltransf_11 PF08241.12 KOH00536.1 - 0.002 18.7 0.0 0.0074 16.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain AAA_2 PF07724.14 KOH00537.1 - 1.4e-35 122.9 0.9 7.3e-35 120.6 0.9 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 KOH00537.1 - 9.2e-15 55.2 0.3 1.9e-14 54.2 0.3 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOH00537.1 - 3.9e-08 33.4 0.0 9.7e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 KOH00537.1 - 7.8e-08 32.3 0.0 2e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein Mg_chelatase PF01078.21 KOH00537.1 - 3.3e-05 23.4 0.1 0.0024 17.3 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 KOH00537.1 - 4.9e-05 23.6 0.9 0.00087 19.6 0.4 2.9 2 2 1 3 3 2 1 AAA domain AAA_16 PF13191.6 KOH00537.1 - 8.5e-05 23.0 0.1 0.00024 21.5 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 KOH00537.1 - 0.00013 21.7 0.1 0.033 13.9 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 KOH00537.1 - 0.00025 21.1 0.0 0.00065 19.8 0.0 1.7 1 0 0 1 1 1 1 Sigma-54 interaction domain MCM PF00493.23 KOH00537.1 - 0.00054 19.1 0.1 0.0011 18.1 0.1 1.5 1 0 0 1 1 1 1 MCM P-loop domain RuvB_N PF05496.12 KOH00537.1 - 0.00059 19.6 0.3 0.0018 18.1 0.1 1.9 2 1 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 KOH00537.1 - 0.0036 17.3 0.0 0.012 15.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KOH00537.1 - 0.004 16.9 0.0 0.017 14.9 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein T2SSE PF00437.20 KOH00537.1 - 0.0046 16.0 0.0 0.0077 15.3 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_33 PF13671.6 KOH00537.1 - 0.013 15.6 0.0 0.037 14.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KOH00537.1 - 0.015 15.0 3.0 0.026 14.2 0.7 2.5 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 KOH00537.1 - 0.022 15.3 0.6 0.073 13.6 0.1 2.2 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 KOH00537.1 - 0.027 13.9 0.0 0.054 12.9 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_7 PF12775.7 KOH00537.1 - 0.029 13.9 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 KOH00537.1 - 0.033 14.1 0.1 0.25 11.3 0.0 2.3 2 0 0 2 2 2 0 NACHT domain CbiA PF01656.23 KOH00537.1 - 0.04 14.0 0.0 1.1 9.4 0.1 2.4 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain RNA_helicase PF00910.22 KOH00537.1 - 0.045 14.1 0.0 0.24 11.8 0.0 2.3 2 0 0 2 2 2 0 RNA helicase DEAD PF00270.29 KOH00537.1 - 0.056 13.2 2.3 0.7 9.6 0.0 3.2 3 1 1 4 4 4 0 DEAD/DEAH box helicase AAA_29 PF13555.6 KOH00537.1 - 0.057 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TsaE PF02367.17 KOH00537.1 - 0.057 13.4 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 KOH00537.1 - 0.11 13.0 2.0 0.12 12.9 0.4 2.1 1 1 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 KOH00537.1 - 2.7 8.4 13.6 1.3 9.5 3.2 3.2 1 1 1 2 2 2 0 AAA domain GIY-YIG PF01541.24 KOH00538.1 - 1.2e-13 51.1 0.5 3e-13 49.8 0.1 1.9 2 0 0 2 2 2 1 GIY-YIG catalytic domain FANCL_C PF11793.8 KOH00538.1 - 7.2e-06 26.1 4.7 2.3e-05 24.5 4.7 1.9 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING-like PF08746.11 KOH00538.1 - 0.8 10.1 7.6 8.8 6.7 7.7 2.4 1 1 0 1 1 1 0 RING-like domain Glyco_hydro_31 PF01055.26 KOH00539.1 - 2.2e-133 445.7 0.5 4e-133 444.8 0.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 KOH00539.1 - 7.9e-22 77.4 1.6 7e-21 74.3 0.2 3.1 3 0 0 3 3 3 1 Galactose mutarotase-like DUF5110 PF17137.4 KOH00539.1 - 3.3e-07 30.5 0.1 1.7e-06 28.2 0.0 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF5110) Myotoxins PF00819.17 KOH00539.1 - 0.13 12.6 0.1 28 5.1 0.0 2.6 2 0 0 2 2 2 0 Myotoxin, crotamine DUF5353 PF17304.2 KOH00540.1 - 0.032 14.0 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5353) CDC45 PF02724.14 KOH00541.1 - 0.084 11.2 19.5 0.086 11.1 19.5 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 KOH00541.1 - 4.6 6.6 27.3 5.8 6.2 27.3 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 KOH00541.1 - 7 4.7 25.1 7.5 4.6 25.1 1.1 1 0 0 1 1 1 0 Nop14-like family KH_1 PF00013.29 KOH00542.1 - 2.6e-38 129.7 3.0 4.7e-12 45.6 0.6 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 KOH00542.1 - 7.1e-10 38.6 0.3 0.056 13.3 0.0 3.5 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 KOH00542.1 - 1.7e-06 27.8 1.1 0.14 12.1 0.1 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.6 KOH00542.1 - 0.0038 17.3 0.8 8.6 6.5 0.0 3.4 3 0 0 3 3 3 1 NusA-like KH domain Gram_pos_anchor PF00746.21 KOH00542.1 - 0.043 13.8 0.2 0.07 13.1 0.2 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif RskA PF10099.9 KOH00542.1 - 0.074 13.3 0.9 0.15 12.3 0.9 1.4 1 0 0 1 1 1 0 Anti-sigma-K factor rskA RBR PF17208.3 KOH00542.1 - 1.2 9.9 4.8 0.94 10.2 0.9 2.3 2 0 0 2 2 2 0 RNA binding Region CENP-B_dimeris PF09026.10 KOH00542.1 - 7 7.1 8.0 35 4.9 4.3 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DASH_Dad3 PF08656.10 KOH00543.1 - 1.1e-26 92.7 3.9 1.3e-26 92.4 3.9 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad3 WD40 PF00400.32 KOH00544.1 - 3.4e-10 40.4 9.0 0.0036 18.1 0.3 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00544.1 - 9.7e-08 32.2 0.1 0.023 15.0 0.0 4.2 3 3 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain AA_permease PF00324.21 KOH00545.1 - 5.8e-46 157.1 36.8 9.3e-46 156.4 36.8 1.3 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 KOH00545.1 - 6.6e-17 61.6 3.6 6.8e-08 31.9 0.0 3.2 2 1 1 3 3 3 3 Solute carrier family 12 Pox_MCEL PF03291.16 KOH00546.1 - 1.4e-107 359.7 0.0 2.2e-107 359.0 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 KOH00546.1 - 1.7e-11 44.7 0.0 3.2e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOH00546.1 - 3.9e-09 37.1 0.2 1.2e-08 35.6 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOH00546.1 - 6.9e-09 36.3 0.0 1.5e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOH00546.1 - 8.4e-08 32.2 0.0 1.9e-07 31.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOH00546.1 - 8.5e-06 25.6 0.0 1.6e-05 24.7 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 KOH00546.1 - 0.00064 19.0 0.0 0.0016 17.7 0.0 1.6 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Metaviral_G PF09595.10 KOH00546.1 - 0.0082 16.2 0.7 0.012 15.7 0.7 1.2 1 0 0 1 1 1 1 Metaviral_G glycoprotein CMAS PF02353.20 KOH00546.1 - 0.0094 15.3 0.0 0.036 13.4 0.0 1.8 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase MetW PF07021.12 KOH00546.1 - 0.06 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW TPMT PF05724.11 KOH00546.1 - 0.066 12.9 0.0 0.15 11.7 0.0 1.5 2 0 0 2 2 2 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_4 PF02390.17 KOH00546.1 - 0.075 12.5 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase DUF3682 PF12446.8 KOH00546.1 - 0.11 13.0 3.4 0.18 12.3 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Bac_small_YrzI PF09501.10 KOH00546.1 - 4.9 7.4 8.1 12 6.1 8.1 1.6 1 0 0 1 1 1 0 Probable sporulation protein (Bac_small_yrzI) DEAD PF00270.29 KOH00547.1 - 2.2e-46 157.8 0.1 5.8e-46 156.5 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOH00547.1 - 8.8e-21 74.3 0.1 5.8e-20 71.7 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOH00547.1 - 2.8e-07 30.7 0.0 2.8e-07 30.7 0.0 3.7 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Neur_chan_memb PF02932.16 KOH00548.1 - 0.19 11.8 3.6 0.41 10.7 3.6 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 KOH00548.1 - 9.3 5.4 11.2 15 4.7 11.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PAS PF00989.25 KOH00549.1 - 3.4e-19 68.9 0.0 5.6e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.18 KOH00549.1 - 1.6e-07 31.3 7.6 3e-07 30.5 7.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_4 PF08448.10 KOH00549.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 PAS fold Zn_clus PF00172.18 KOH00550.1 - 1.1e-11 44.7 6.4 5.4e-11 42.4 6.4 2.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Competence PF03772.16 KOH00551.1 - 0.053 12.8 0.7 0.081 12.2 0.7 1.2 1 0 0 1 1 1 0 Competence protein Sugar_tr PF00083.24 KOH00552.1 - 9.1e-115 384.1 17.1 1.1e-114 383.8 17.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOH00552.1 - 7.9e-30 104.0 47.9 3e-29 102.1 22.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 KOH00552.1 - 0.0006 19.2 5.5 0.0006 19.2 5.5 2.3 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB HD_3 PF13023.6 KOH00553.1 - 8.4e-37 126.6 0.1 1.1e-36 126.3 0.1 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 KOH00553.1 - 1.9e-09 37.5 0.1 2.7e-09 37.0 0.1 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 KOH00553.1 - 5.8e-06 26.5 0.2 1.7e-05 25.0 0.2 1.7 1 1 0 1 1 1 1 HD domain Unstab_antitox PF09720.10 KOH00553.1 - 0.16 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative addiction module component Glycos_transf_4 PF00953.21 KOH00554.1 - 1.9e-33 115.7 9.0 1.9e-33 115.7 9.0 2.0 2 1 0 2 2 2 1 Glycosyl transferase family 4 DUF3413 PF11893.8 KOH00554.1 - 0.52 9.4 11.0 0.04 13.1 3.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3413) GSHPx PF00255.19 KOH00555.1 - 9.8e-50 166.7 2.3 1.3e-49 166.3 2.3 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 KOH00555.1 - 4.9e-06 26.5 0.8 3.7e-05 23.6 0.8 2.0 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KOH00555.1 - 0.00029 20.6 0.3 0.0016 18.2 0.3 1.9 1 1 0 1 1 1 1 Redoxin SNF2_N PF00176.23 KOH00556.1 - 3.4e-78 262.8 0.1 7.2e-78 261.7 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 KOH00556.1 - 1.4e-38 131.4 2.1 1.4e-38 131.4 2.1 3.7 3 0 0 3 3 3 1 SLIDE HAND PF09110.11 KOH00556.1 - 2.9e-32 111.7 1.0 2.9e-32 111.7 1.0 4.0 4 0 0 4 4 4 1 HAND Helicase_C PF00271.31 KOH00556.1 - 3.7e-19 69.1 0.0 1.5e-18 67.2 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOH00556.1 - 4.6e-13 49.5 0.3 2.8e-11 43.7 0.0 3.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOH00556.1 - 0.00034 20.4 0.0 0.00091 19.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 KOH00556.1 - 0.0013 18.0 0.5 0.0049 16.1 0.1 2.1 1 1 1 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 KOH00556.1 - 0.0013 18.4 0.2 0.0071 16.0 0.0 2.4 2 0 0 2 2 2 1 SWI2/SNF2 ATPase DEAD_2 PF06733.15 KOH00556.1 - 0.025 14.2 0.1 0.063 12.9 0.1 1.6 1 0 0 1 1 1 0 DEAD_2 AAA_14 PF13173.6 KOH00556.1 - 0.045 13.8 1.1 0.13 12.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 KOH00557.1 - 0.015 16.2 7.1 40 5.3 0.0 5.1 5 0 0 5 5 5 0 WD domain, G-beta repeat COQ9 PF08511.11 KOH00557.1 - 0.11 12.3 0.0 0.4 10.5 0.0 2.0 2 0 0 2 2 2 0 COQ9 Bystin PF05291.11 KOH00558.1 - 6.7e-121 403.1 0.0 9.8e-121 402.5 0.0 1.2 1 0 0 1 1 1 1 Bystin His_biosynth PF00977.21 KOH00559.1 - 2.6e-44 151.4 0.3 2.7e-43 148.1 0.1 2.7 2 1 0 2 2 2 1 Histidine biosynthesis protein GATase PF00117.28 KOH00559.1 - 5.1e-26 91.6 0.0 8.2e-26 90.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 KOH00559.1 - 2.3e-07 30.9 0.0 0.0013 18.6 0.0 2.3 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 KOH00559.1 - 2.8e-06 27.1 0.0 5.6e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 KOH00559.1 - 3.3e-05 23.7 0.0 0.056 13.2 0.0 2.2 2 0 0 2 2 2 2 Peptidase C26 NMO PF03060.15 KOH00559.1 - 0.011 15.1 0.2 0.16 11.3 0.0 2.1 2 0 0 2 2 2 0 Nitronate monooxygenase ThiG PF05690.14 KOH00559.1 - 0.086 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG DAHP_synth_1 PF00793.20 KOH00560.1 - 3.6e-111 370.4 0.1 4.4e-111 370.2 0.1 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Arrestin_N PF00339.29 KOH00561.1 - 8.4e-06 25.9 0.3 2e-05 24.7 0.3 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Ribosomal_S5 PF00333.20 KOH00562.1 - 1.1e-23 83.0 0.2 2.2e-23 82.0 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 KOH00562.1 - 3.6e-22 77.6 0.0 9.2e-22 76.3 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain dUTPase PF00692.19 KOH00563.1 - 3e-46 156.3 0.1 3.9e-46 155.9 0.1 1.2 1 0 0 1 1 1 1 dUTPase RseA_C PF03873.13 KOH00563.1 - 0.17 12.1 0.3 14 6.0 0.1 2.5 1 1 1 2 2 2 0 Anti sigma-E protein RseA, C-terminal domain Med22 PF06179.12 KOH00564.1 - 1.4e-21 76.6 5.3 1.6e-21 76.4 5.3 1.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex GCIP PF13324.6 KOH00564.1 - 0.011 15.4 1.9 0.012 15.2 1.9 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Sedlin_N PF04628.13 KOH00565.1 - 6.9e-53 178.3 0.0 8e-53 178.1 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 KOH00565.1 - 4.9e-07 29.8 0.1 6.8e-07 29.3 0.1 1.6 1 1 0 1 1 1 1 Sybindin-like family DUF2040 PF09745.9 KOH00566.1 - 1.1 9.3 5.0 3.5 7.7 0.8 2.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 55 (DUF2040) Lum_binding PF00677.17 KOH00568.1 - 1.4e-42 143.5 1.1 5.1e-20 71.2 0.3 2.3 2 0 0 2 2 2 2 Lumazine binding domain Nairovirus_M PF07948.11 KOH00568.1 - 0.016 13.5 0.0 0.025 12.8 0.0 1.3 1 0 0 1 1 1 0 Nairovirus M polyprotein-like UPF0086 PF01868.16 KOH00569.1 - 1.1e-22 79.7 0.0 2e-22 78.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 CtIP_N PF10482.9 KOH00569.1 - 1 9.4 11.8 0.64 10.1 7.1 2.3 1 1 1 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain COMPASS-Shg1 PF05205.12 KOH00570.1 - 3.9e-27 94.9 4.2 4.6e-27 94.7 4.2 1.1 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 RhoGAP PF00620.27 KOH00572.1 - 5.1e-40 136.8 0.2 5.6e-39 133.4 0.0 2.5 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 KOH00572.1 - 4.7e-06 26.8 9.5 7.1e-05 23.0 9.5 2.5 1 1 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Prominin PF05478.11 KOH00572.1 - 0.0046 15.0 3.8 0.0084 14.1 3.8 1.3 1 0 0 1 1 1 1 Prominin Ead_Ea22 PF13935.6 KOH00572.1 - 0.071 13.8 0.9 0.69 10.6 0.2 2.3 1 1 1 2 2 2 0 Ead/Ea22-like protein Ribosomal_S20p PF01649.18 KOH00572.1 - 0.57 10.9 3.4 4.1 8.1 0.4 2.9 1 1 1 2 2 2 0 Ribosomal protein S20 PIN_2 PF10130.9 KOH00572.1 - 0.63 10.3 5.2 0.88 9.8 0.4 2.8 2 1 1 3 3 3 0 PIN domain Exonuc_VII_L PF02601.15 KOH00572.1 - 1.2 8.6 6.1 2 7.9 6.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit MSV199 PF10553.9 KOH00572.1 - 1.8 8.8 8.1 10 6.3 1.6 2.6 2 0 0 2 2 2 0 MSV199 domain Methyltransf_PK PF05891.12 KOH00573.1 - 7.4e-100 332.9 0.0 8.8e-100 332.7 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 KOH00573.1 - 7.8e-08 32.9 0.0 1.4e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOH00573.1 - 6e-07 29.4 0.0 3.6e-06 26.9 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOH00573.1 - 0.0021 18.7 0.0 0.004 17.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 KOH00573.1 - 0.017 14.4 0.1 0.034 13.5 0.1 1.5 1 1 0 1 1 1 0 O-methyltransferase domain Methyltransf_12 PF08242.12 KOH00573.1 - 0.11 13.3 0.0 0.24 12.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KOH00573.1 - 0.15 11.6 0.0 0.29 10.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain DUF1318 PF07027.12 KOH00573.1 - 0.2 12.1 0.0 27 5.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1318) AIM5 PF17050.5 KOH00574.1 - 1.5e-06 28.9 0.8 2e-06 28.5 0.8 1.3 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 SHMT PF00464.19 KOH00575.1 - 2.1e-208 691.8 0.0 2.5e-208 691.5 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Ras PF00071.22 KOH00576.1 - 7.1e-43 146.0 0.0 9e-43 145.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOH00576.1 - 4.7e-36 123.6 0.1 6.7e-36 123.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOH00576.1 - 4.3e-13 49.1 0.0 5.5e-13 48.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOH00576.1 - 6.9e-09 35.5 0.1 3.2e-08 33.4 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KOH00576.1 - 2.1e-08 33.8 0.0 3.5e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KOH00576.1 - 2.5e-06 27.5 0.8 0.01 15.8 0.0 2.2 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KOH00576.1 - 3e-06 27.3 0.0 4.6e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KOH00576.1 - 0.00062 19.3 0.1 0.0013 18.2 0.1 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KOH00576.1 - 0.00078 18.7 0.8 0.61 9.2 0.1 2.6 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1_Xtn PF16897.5 KOH00576.1 - 0.00091 19.2 0.1 0.0022 18.0 0.0 1.6 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 KOH00576.1 - 0.0012 18.4 0.1 0.0081 15.7 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 KOH00576.1 - 0.0093 16.4 0.0 0.014 15.8 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 KOH00576.1 - 0.025 14.0 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_7 PF12775.7 KOH00576.1 - 0.068 12.7 0.1 0.095 12.2 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 KOH00576.1 - 0.085 13.1 0.1 0.18 12.1 0.1 1.4 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 KOH00576.1 - 0.091 12.0 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 Septin adh_short PF00106.25 KOH00577.1 - 1.4e-21 76.9 0.0 1e-12 48.0 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 KOH00577.1 - 7.9e-11 42.2 0.0 1.2e-10 41.6 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 KOH00577.1 - 6.5e-09 35.7 0.0 1.4e-08 34.6 0.0 1.5 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 KOH00577.1 - 0.002 17.4 0.1 0.0044 16.2 0.1 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein DUF3349 PF11829.8 KOH00577.1 - 0.028 15.2 0.0 0.058 14.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3349) Fer4_23 PF18009.1 KOH00577.1 - 0.042 14.3 0.0 0.097 13.1 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S iron-sulfur cluster binding domain DUF1774 PF08611.10 KOH00577.1 - 0.054 13.8 0.1 0.088 13.1 0.1 1.4 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1774) DUF1788 PF08747.11 KOH00577.1 - 0.084 12.9 0.0 0.35 10.9 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1788) zf-C2H2_2 PF12756.7 KOH00578.1 - 5.4e-34 116.6 5.5 1.5e-31 108.7 3.0 2.5 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) DUF2024 PF09630.10 KOH00578.1 - 0.032 14.1 0.1 0.081 12.8 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) Ribosomal_L37 PF08561.10 KOH00579.1 - 2.5e-21 76.4 10.4 1e-16 61.5 0.8 2.1 1 1 1 2 2 2 2 Mitochondrial ribosomal protein L37 DUF1674 PF07896.12 KOH00580.1 - 6.6e-19 68.1 2.2 1.4e-18 67.1 2.2 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) HbrB PF08539.11 KOH00581.1 - 1.7e-32 112.7 2.4 1.7e-32 112.7 2.4 2.5 2 1 0 2 2 2 1 HbrB-like DUF5377 PF17347.2 KOH00581.1 - 0.12 12.7 0.5 0.27 11.6 0.5 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5377) Methyltransf_16 PF10294.9 KOH00582.1 - 1.4e-23 83.5 0.0 2.4e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 KOH00582.1 - 1.7e-06 28.0 0.0 5e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOH00582.1 - 6e-05 22.9 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 KOH00582.1 - 0.0042 16.7 0.0 0.0093 15.6 0.0 1.5 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_12 PF08242.12 KOH00582.1 - 0.0049 17.6 0.0 0.015 16.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOH00582.1 - 0.0074 17.0 0.0 0.018 15.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOH00582.1 - 0.025 14.2 0.0 0.039 13.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain TRM PF02005.16 KOH00582.1 - 0.037 13.2 0.0 0.061 12.5 0.0 1.4 1 1 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Osmo_CC PF08946.10 KOH00582.1 - 0.18 12.1 0.6 0.47 10.7 0.1 2.0 2 0 0 2 2 2 0 Osmosensory transporter coiled coil HSM3_N PF18795.1 KOH00583.1 - 2.7e-101 338.0 16.4 4.6e-101 337.2 16.4 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein HSM3, N terminal domain HSM3_C PF18794.1 KOH00583.1 - 1.8e-77 258.9 1.4 3.7e-77 257.9 1.4 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein HSM3, C terminal domain UBX PF00789.20 KOH00584.1 - 1.2e-23 83.1 0.2 7.3e-23 80.6 0.0 2.4 3 0 0 3 3 3 1 UBX domain Pkinase PF00069.25 KOH00585.1 - 1.2e-61 208.4 0.0 1.7e-61 207.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00585.1 - 3.1e-35 121.7 0.0 7.8e-35 120.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KOH00585.1 - 4.5e-06 26.2 0.0 7.4e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOH00585.1 - 0.00013 20.9 0.0 0.00023 20.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 KOH00585.1 - 0.0032 16.5 0.0 0.0032 16.5 0.0 1.5 2 0 0 2 2 2 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 KOH00585.1 - 0.013 14.6 0.1 0.03 13.4 0.0 1.6 2 0 0 2 2 2 0 Seadornavirus VP7 Kdo PF06293.14 KOH00585.1 - 0.017 14.5 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KOH00585.1 - 0.052 13.1 0.4 0.24 10.9 0.0 2.0 2 0 0 2 2 2 0 Choline/ethanolamine kinase Rif1_N PF12231.8 KOH00586.1 - 1.5e-70 238.1 11.1 3.5e-70 236.9 11.1 1.6 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal DSPc PF00782.20 KOH00587.1 - 3.7e-24 85.0 0.0 7.1e-19 67.9 0.0 3.4 2 1 0 3 3 3 3 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOH00587.1 - 0.00072 19.2 0.0 0.0015 18.1 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KOH00587.1 - 0.075 13.1 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate CBFD_NFYB_HMF PF00808.23 KOH00588.1 - 0.0041 17.4 0.0 0.0079 16.5 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOH00588.1 - 0.19 12.1 2.2 0.21 12.0 0.0 2.0 2 1 0 2 2 2 0 Core histone H2A/H2B/H3/H4 CobT PF06213.12 KOH00588.1 - 0.42 9.9 14.0 0.51 9.7 14.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 KOH00588.1 - 2 6.4 19.1 2 6.4 19.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 KOH00588.1 - 2.4 6.3 17.3 2.6 6.1 17.3 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 KOH00588.1 - 3.7 5.7 12.3 4.2 5.5 12.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Pox_Ag35 PF03286.14 KOH00588.1 - 5.6 6.7 11.2 9.7 5.9 11.2 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Paf1 PF03985.13 KOH00589.1 - 1.7e-100 337.0 18.9 2.1e-100 336.7 18.9 1.0 1 0 0 1 1 1 1 Paf1 RNA_polI_A34 PF08208.11 KOH00589.1 - 0.0091 16.1 7.6 0.017 15.2 7.6 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 GEN1_C PF18380.1 KOH00589.1 - 0.29 12.1 7.7 0.96 10.4 7.7 1.9 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain RP-C_C PF11800.8 KOH00589.1 - 1.3 9.1 6.9 2 8.4 6.9 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region RCC1_2 PF13540.6 KOH00590.1 - 6.1e-19 67.3 13.7 1.3e-10 40.8 1.9 4.8 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 KOH00590.1 - 2.1e-17 63.4 3.3 3.1e-05 24.5 0.3 6.1 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat PQQ PF01011.21 KOH00590.1 - 0.22 11.5 1.0 0.64 10.1 0.1 2.3 3 0 0 3 3 3 0 PQQ enzyme repeat Peptidase_M20 PF01546.28 KOH00591.1 - 2.3e-20 73.2 0.0 3.5e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KOH00591.1 - 2.7e-13 49.8 0.0 5.6e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain WD40 PF00400.32 KOH00591.1 - 2.7e-12 47.0 1.7 0.0071 17.2 0.0 6.0 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00591.1 - 0.0023 18.2 0.0 4.1 7.8 0.0 3.2 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain MRP-L27 PF09809.9 KOH00592.1 - 7.8e-34 115.9 0.4 1.1e-33 115.4 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 SecY PF00344.20 KOH00593.1 - 6.2e-42 143.9 19.0 8.6e-42 143.4 19.0 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 KOH00593.1 - 2.2e-09 37.0 0.1 2.2e-09 37.0 0.1 2.1 2 0 0 2 2 2 1 Plug domain of Sec61p DUF99 PF01949.16 KOH00593.1 - 0.095 12.1 0.2 0.18 11.2 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF99 A_deaminase PF00962.22 KOH00594.1 - 1.2e-31 110.3 0.0 2.7e-30 105.8 0.0 2.6 1 1 0 1 1 1 1 Adenosine/AMP deaminase YliH PF10799.8 KOH00594.1 - 0.036 14.0 0.1 0.075 13.0 0.1 1.4 1 0 0 1 1 1 0 Biofilm formation protein (YliH/bssR) Peptidase_M28 PF04389.17 KOH00596.1 - 4.2e-41 140.8 0.2 6.3e-41 140.3 0.2 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 KOH00596.1 - 1.4e-08 34.6 0.0 3.4e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 KOH00596.1 - 0.0027 17.5 0.0 0.0054 16.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 KOH00596.1 - 0.017 14.1 0.0 0.041 12.9 0.0 1.6 1 0 0 1 1 1 0 M42 glutamyl aminopeptidase Mem_trans PF03547.18 KOH00597.1 - 2.8e-77 259.7 11.3 4.6e-77 259.0 11.3 1.3 1 1 0 1 1 1 1 Membrane transport protein FixS PF03597.15 KOH00597.1 - 0.031 14.0 4.2 4.8 7.0 0.3 3.4 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type Adap_comp_sub PF00928.21 KOH00598.1 - 5.6e-45 153.8 0.1 1.9e-44 152.0 0.0 1.7 1 1 1 2 2 2 2 Adaptor complexes medium subunit family Spt20 PF12090.8 KOH00598.1 - 0.0062 16.2 0.7 0.011 15.4 0.7 1.3 1 0 0 1 1 1 1 Spt20 family DUF3947 PF13135.6 KOH00598.1 - 3 8.1 6.4 6.2 7.1 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) SNF5 PF04855.12 KOH00599.1 - 7.8e-52 176.4 6.0 7.8e-52 176.4 6.0 5.0 3 2 0 3 3 3 1 SNF5 / SMARCB1 / INI1 CNDH2_C PF16858.5 KOH00599.1 - 0.079 12.8 31.1 0.027 14.3 18.1 2.5 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF2370 PF10176.9 KOH00600.1 - 3.9e-85 285.1 0.1 5.9e-85 284.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) Sigma70_ner PF04546.13 KOH00600.1 - 0.0026 17.7 0.5 0.0049 16.8 0.5 1.4 1 0 0 1 1 1 1 Sigma-70, non-essential region Mito_carr PF00153.27 KOH00601.1 - 4.6e-63 209.2 0.9 5.3e-21 74.3 0.4 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 KOH00601.1 - 0.061 13.7 2.7 2.3 8.6 0.4 3.4 1 1 3 4 4 4 0 Tim17/Tim22/Tim23/Pmp24 family Serine_protease PF18405.1 KOH00601.1 - 0.062 12.5 1.1 5 6.2 0.0 2.9 2 1 0 2 2 2 0 Gammaproteobacterial serine protease MFS_1 PF07690.16 KOH00602.1 - 1.2e-42 146.1 48.9 1.3e-40 139.4 48.9 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOH00602.1 - 4.4e-14 52.2 14.8 4.4e-14 52.2 14.8 3.3 2 1 1 4 4 4 2 Sugar (and other) transporter DUF4514 PF14986.6 KOH00602.1 - 0.11 12.5 0.1 6.6 6.8 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4514) Sulfate_transp PF00916.20 KOH00603.1 - 1.1e-122 409.5 12.9 1.7e-122 408.9 12.9 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 KOH00603.1 - 5.7e-08 32.4 0.0 2.7e-07 30.2 0.0 2.1 3 0 0 3 3 3 1 STAS domain STAS_2 PF13466.6 KOH00603.1 - 0.0047 17.2 0.0 0.0096 16.3 0.0 1.4 1 0 0 1 1 1 1 STAS domain DUF3611 PF12263.8 KOH00603.1 - 1.2 9.0 6.7 23 4.8 0.0 3.9 2 1 0 3 3 3 0 Protein of unknown function (DUF3611) MFS_MOT1 PF16983.5 KOH00603.1 - 1.3 9.5 9.0 0.061 13.7 0.6 2.6 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily PHO4 PF01384.20 KOH00604.1 - 2.6e-117 391.6 15.3 3.2e-117 391.4 15.3 1.1 1 0 0 1 1 1 1 Phosphate transporter family Tautomerase PF01361.21 KOH00604.1 - 0.019 14.8 0.0 0.055 13.4 0.0 1.7 1 0 0 1 1 1 0 Tautomerase enzyme MIP PF00230.20 KOH00605.1 - 1.6e-49 168.7 10.1 2.3e-49 168.2 10.1 1.2 1 0 0 1 1 1 1 Major intrinsic protein DUF4624 PF15417.6 KOH00605.1 - 0.099 12.5 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4624) Dak1 PF02733.17 KOH00606.1 - 8.6e-108 359.9 1.4 1.1e-107 359.5 1.4 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 KOH00606.1 - 5.5e-45 153.4 2.8 1.3e-44 152.2 2.8 1.7 1 0 0 1 1 1 1 DAK2 domain Hpt PF01627.23 KOH00606.1 - 0.2 12.0 0.5 1.2 9.5 0.2 2.3 2 0 0 2 2 2 0 Hpt domain DUF1349 PF07081.11 KOH00607.1 - 4.6e-62 208.9 0.0 5.1e-62 208.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) GH43_C2 PF17851.1 KOH00607.1 - 2.3e-05 24.2 0.0 3.5e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain zf-rbx1 PF12678.7 KOH00608.1 - 0.046 14.0 0.1 0.1 12.9 0.1 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain MCM_OB PF17207.3 KOH00609.1 - 7.5e-07 29.0 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 MCM OB domain Homeodomain PF00046.29 KOH00611.1 - 4.4e-09 36.0 1.2 4.4e-09 36.0 1.2 1.8 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KOH00611.1 - 7.6e-07 28.9 0.5 7.6e-07 28.9 0.5 2.2 2 0 0 2 2 2 1 Homeobox KN domain GCIP PF13324.6 KOH00611.1 - 0.013 15.1 1.3 0.023 14.3 1.3 1.4 1 1 0 1 1 1 0 Grap2 and cyclin-D-interacting Homez PF11569.8 KOH00611.1 - 0.039 13.4 0.1 0.44 10.0 0.0 2.2 1 1 1 2 2 2 0 Homeodomain leucine-zipper encoding, Homez MATalpha_HMGbox PF04769.12 KOH00612.1 - 4.7e-15 55.4 0.4 6.2e-15 55.1 0.4 1.1 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box Vac17 PF17321.2 KOH00613.1 - 1e-134 450.3 26.8 1.5e-134 449.8 26.8 1.2 1 0 0 1 1 1 1 Vacuole-related protein 17 PuR_N PF09182.10 KOH00613.1 - 0.17 11.8 0.2 0.76 9.7 0.2 2.1 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal MRP-S26 PF14943.6 KOH00613.1 - 0.26 11.2 4.8 0.074 13.0 1.5 1.7 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 SLX9 PF15341.6 KOH00613.1 - 0.68 10.3 10.4 0.32 11.4 0.2 2.8 3 0 0 3 3 3 0 Ribosome biogenesis protein SLX9 KH_8 PF17903.1 KOH00614.1 - 1.5e-31 108.3 0.1 1.5e-31 108.3 0.1 1.9 2 0 0 2 2 2 1 Krr1 KH1 domain KH_1 PF00013.29 KOH00614.1 - 0.024 14.5 0.3 0.081 12.8 0.0 2.0 2 0 0 2 2 2 0 KH domain Spore_GerAC PF05504.11 KOH00614.1 - 0.12 12.5 2.1 5.3 7.2 1.3 2.5 2 0 0 2 2 2 0 Spore germination B3/ GerAC like, C-terminal DUF543 PF04418.12 KOH00616.1 - 2.5e-31 107.5 0.1 3e-31 107.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Peptidase_M3 PF01432.20 KOH00617.1 - 3.4e-158 527.7 1.3 4.2e-158 527.4 1.3 1.1 1 0 0 1 1 1 1 Peptidase family M3 ABA_GPCR PF12430.8 KOH00618.1 - 0.033 14.0 1.0 0.041 13.6 1.0 1.2 1 0 0 1 1 1 0 Abscisic acid G-protein coupled receptor MT-A70 PF05063.14 KOH00619.1 - 2.2e-13 50.5 0.1 3.2e-13 50.0 0.1 1.3 1 0 0 1 1 1 1 MT-A70 Spb1_C PF07780.12 KOH00620.1 - 2.6e-81 272.3 27.9 2.6e-81 272.3 27.9 2.9 2 1 0 2 2 2 1 Spb1 C-terminal domain FtsJ PF01728.19 KOH00620.1 - 1e-53 182.0 0.1 2.4e-53 180.9 0.1 1.7 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 KOH00620.1 - 1.9e-43 148.1 16.1 1.9e-43 148.1 16.1 4.6 4 2 0 4 4 4 1 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.6 KOH00620.1 - 0.057 13.3 0.1 0.22 11.3 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain PIG-X PF08320.12 KOH00621.1 - 5.6e-31 108.1 0.0 7.5e-31 107.7 0.0 1.2 1 0 0 1 1 1 1 PIG-X / PBN1 ATP_transf PF09830.9 KOH00623.1 - 8e-19 67.6 0.0 1.4e-18 66.8 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4931 PF16285.5 KOH00623.1 - 4.6e-05 22.9 0.0 0.0001 21.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4931) DUF4922 PF16269.5 KOH00623.1 - 7.7e-05 22.5 0.1 0.0013 18.5 0.1 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4922) HIT PF01230.23 KOH00623.1 - 0.085 13.6 0.0 0.18 12.6 0.0 1.6 1 0 0 1 1 1 0 HIT domain Recep_L_domain PF01030.24 KOH00625.1 - 5.4e-10 39.4 15.9 0.00069 19.7 0.0 5.0 1 1 2 4 4 4 3 Receptor L domain LRR_5 PF13306.6 KOH00625.1 - 0.0075 16.2 0.7 0.0075 16.2 0.7 2.9 1 1 2 3 3 3 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KOH00625.1 - 2 7.9 7.3 1.4 8.4 3.6 2.5 1 1 2 3 3 3 0 Leucine-rich repeat CTP_transf_like PF01467.26 KOH00626.1 - 7.9e-07 29.4 0.0 2.2e-06 27.9 0.0 1.7 1 1 0 1 1 1 1 Cytidylyltransferase-like ATP-sulfurylase PF01747.17 KOH00626.1 - 0.091 12.2 0.1 0.21 11.0 0.1 1.8 1 1 0 1 1 1 0 ATP-sulfurylase EMC1_C PF07774.13 KOH00627.1 - 2.4e-62 210.4 0.3 3.8e-62 209.7 0.3 1.3 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal Mgr1 PF08602.10 KOH00628.1 - 1.2e-159 531.3 0.3 1e-113 380.1 0.3 2.0 1 1 1 2 2 2 2 Mgr1-like, i-AAA protease complex subunit Thioredoxin PF00085.20 KOH00629.1 - 5.1e-62 206.3 0.2 5.1e-30 103.5 0.1 3.4 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 KOH00629.1 - 6.7e-25 88.1 1.9 1.1e-17 64.6 1.0 3.3 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KOH00629.1 - 5.5e-09 36.1 0.0 0.00019 21.6 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 KOH00629.1 - 7.3e-07 28.8 0.1 0.017 14.5 0.2 2.3 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 KOH00629.1 - 2.5e-06 27.4 0.0 0.05 13.5 0.0 2.7 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_2 PF13098.6 KOH00629.1 - 3.1e-06 27.6 0.2 0.0062 17.0 0.0 3.1 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOH00629.1 - 1.4e-05 25.3 0.0 0.18 12.1 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin-like TraF PF13728.6 KOH00629.1 - 0.017 15.0 0.0 0.1 12.4 0.0 2.2 2 0 0 2 2 2 0 F plasmid transfer operon protein Redoxin PF08534.10 KOH00629.1 - 0.017 14.8 0.1 1.2 8.9 0.0 2.4 2 0 0 2 2 2 0 Redoxin Thioredoxin_9 PF14595.6 KOH00629.1 - 0.031 14.0 0.3 8.6 6.1 0.0 2.8 3 0 0 3 3 3 0 Thioredoxin Hexokinase_2 PF03727.16 KOH00630.1 - 6.2e-76 255.0 0.0 8.5e-76 254.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KOH00630.1 - 6.3e-70 235.1 0.0 1.2e-69 234.2 0.0 1.5 1 0 0 1 1 1 1 Hexokinase WD40 PF00400.32 KOH00631.1 - 3.2e-13 49.9 7.2 0.0069 17.2 0.1 6.6 6 1 1 7 7 7 4 WD domain, G-beta repeat DUF4221 PF13970.6 KOH00631.1 - 5.3e-05 22.9 0.1 0.00015 21.5 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4221) ANAPC4_WD40 PF12894.7 KOH00631.1 - 0.0018 18.6 0.0 3.6 8.0 0.0 3.7 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain ATG22 PF11700.8 KOH00632.1 - 3.1e-153 510.9 28.0 3.6e-153 510.7 28.0 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 KOH00632.1 - 9.1e-06 24.8 44.6 2.2e-05 23.6 19.1 3.4 2 2 1 3 3 3 2 Major Facilitator Superfamily La PF05383.17 KOH00633.1 - 1.1e-16 60.6 0.1 3e-16 59.2 0.0 1.8 2 0 0 2 2 2 1 La domain Hid1 PF12722.7 KOH00633.1 - 8.7 4.3 23.6 3.3 5.7 20.9 1.6 1 1 0 1 1 1 0 High-temperature-induced dauer-formation protein Glutaredoxin PF00462.24 KOH00634.1 - 6.1e-15 55.2 0.0 9.5e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 KOH00634.1 - 0.0031 17.5 0.1 0.0049 16.9 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin domain DSBA PF01323.20 KOH00634.1 - 0.053 13.3 0.5 3.1 7.5 0.0 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 KOH00634.1 - 0.072 13.5 0.1 0.11 13.0 0.1 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_4 PF13462.6 KOH00634.1 - 0.15 12.3 0.3 1.3 9.1 0.0 1.9 1 1 1 2 2 2 0 Thioredoxin GST_N_2 PF13409.6 KOH00634.1 - 0.16 12.3 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GAT PF03127.14 KOH00635.1 - 0.00097 19.4 0.0 0.0027 18.0 0.0 1.8 1 0 0 1 1 1 1 GAT domain VHS PF00790.19 KOH00635.1 - 0.0034 17.2 0.0 0.0061 16.4 0.0 1.4 1 0 0 1 1 1 1 VHS domain PG_binding_4 PF12229.8 KOH00635.1 - 0.034 14.4 0.1 0.086 13.1 0.1 1.7 1 1 0 1 1 1 0 Putative peptidoglycan binding domain SelR PF01641.18 KOH00636.1 - 4.7e-45 152.6 0.0 5.9e-45 152.2 0.0 1.1 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.14 KOH00636.1 - 0.049 13.9 0.6 0.12 12.6 0.6 1.7 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-Mss51 PF13824.6 KOH00636.1 - 0.71 10.0 4.3 7.3 6.8 0.6 3.0 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 SAM_Ste50p PF09235.10 KOH00637.1 - 1.5e-36 124.5 6.3 2.7e-36 123.6 6.3 1.4 1 0 0 1 1 1 1 Ste50p, sterile alpha motif RA PF00788.23 KOH00637.1 - 2.5e-15 56.9 0.0 6.2e-15 55.6 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain FapA PF03961.13 KOH00637.1 - 0.14 10.8 0.6 0.22 10.1 0.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A RRM_Rrp7 PF17799.1 KOH00638.1 - 2.3e-40 138.1 1.2 2.3e-40 138.1 1.2 1.9 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain RRP7 PF12923.7 KOH00638.1 - 1.1e-26 93.3 9.7 3.2e-26 91.8 9.8 1.7 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Glyoxalase_2 PF12681.7 KOH00638.1 - 0.0021 18.0 2.0 0.0082 16.1 0.0 2.4 1 1 0 2 2 2 1 Glyoxalase-like domain DUF547 PF04784.14 KOH00638.1 - 0.058 13.4 0.4 0.13 12.3 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF547 Histidinol_dh PF00815.20 KOH00639.1 - 2.2e-160 534.1 0.3 3.6e-160 533.5 0.3 1.3 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 KOH00639.1 - 2.2e-27 94.7 0.1 4.3e-27 93.8 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 KOH00639.1 - 1.2e-13 51.3 0.2 4.6e-13 49.4 0.2 2.0 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase ATP-cone PF03477.16 KOH00639.1 - 0.0026 18.3 1.0 0.12 13.0 0.1 3.3 3 0 0 3 3 3 1 ATP cone domain CAP_GLY PF01302.25 KOH00640.1 - 3.5e-14 52.6 0.0 7.2e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 CAP-Gly domain Lebercilin PF15619.6 KOH00640.1 - 0.00093 18.9 19.4 0.00093 18.9 19.4 2.5 1 1 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease DUF812 PF05667.11 KOH00640.1 - 0.0081 15.1 30.5 0.011 14.7 30.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF948 PF06103.11 KOH00640.1 - 0.2 11.9 2.0 6.4 7.1 0.1 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) zf-CCHC PF00098.23 KOH00640.1 - 0.5 10.5 4.5 0.92 9.7 4.5 1.4 1 0 0 1 1 1 0 Zinc knuckle CLIP1_ZNF PF16641.5 KOH00640.1 - 1.1 9.3 5.0 2.7 8.0 5.0 1.7 1 0 0 1 1 1 0 CLIP1 zinc knuckle Bap31_Bap29_C PF18035.1 KOH00640.1 - 1.2 9.2 24.8 0.061 13.3 1.2 4.3 4 1 1 5 5 5 0 Bap31/Bap29 cytoplasmic coiled-coil domain PspA_IM30 PF04012.12 KOH00640.1 - 1.3 8.6 26.0 0.44 10.1 16.5 2.2 1 1 0 2 2 2 0 PspA/IM30 family DUF3450 PF11932.8 KOH00640.1 - 1.9 7.7 38.0 1.4 8.1 10.9 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) TMPIT PF07851.13 KOH00640.1 - 4 6.6 24.6 0.65 9.2 9.0 2.1 2 0 0 2 2 2 0 TMPIT-like protein TPR_6 PF13174.6 KOH00641.1 - 0.061 14.0 0.5 0.38 11.5 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOH00641.1 - 0.065 13.4 0.0 0.21 11.8 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat SH3_1 PF00018.28 KOH00642.1 - 1e-05 25.0 0.0 4e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 KOH00642.1 - 1.7e-05 24.5 0.0 4.8e-05 23.1 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 KOH00642.1 - 0.0012 18.5 0.0 0.0031 17.2 0.0 1.8 1 1 0 1 1 1 1 Variant SH3 domain Mucin PF01456.17 KOH00642.1 - 0.094 12.7 6.7 0.2 11.7 6.7 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein SKG6 PF08693.10 KOH00642.1 - 0.19 11.2 0.0 0.38 10.2 0.0 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Nitroreductase PF00881.24 KOH00643.1 - 1.1e-06 28.9 0.0 1.8e-06 28.1 0.0 1.4 1 1 0 1 1 1 1 Nitroreductase family AA_permease PF00324.21 KOH00644.1 - 1.5e-130 436.1 37.2 1.7e-130 435.9 37.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOH00644.1 - 2.7e-33 115.5 38.1 3.3e-33 115.2 38.1 1.0 1 0 0 1 1 1 1 Amino acid permease SUR7 PF06687.12 KOH00644.1 - 0.77 9.4 9.2 0.098 12.3 4.0 2.2 2 0 0 2 2 2 0 SUR7/PalI family CrgA PF06781.12 KOH00644.1 - 4.5 7.4 6.7 1.8 8.7 0.3 3.3 3 0 0 3 3 3 0 Cell division protein CrgA Pkinase PF00069.25 KOH00645.1 - 5.5e-70 235.7 0.0 1.3e-69 234.5 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00645.1 - 1.6e-34 119.4 0.0 3.2e-34 118.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Fungal_KA1 PF16797.5 KOH00645.1 - 3.2e-29 101.0 0.2 3.2e-29 101.0 0.2 2.9 3 0 0 3 3 3 1 Fungal kinase associated-1 domain Kinase-like PF14531.6 KOH00645.1 - 2.9e-05 23.6 0.0 5.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOH00645.1 - 0.035 13.5 0.0 0.08 12.3 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOH00645.1 - 0.036 14.0 0.0 0.062 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Cation_ATPase PF13246.6 KOH00645.1 - 0.076 13.1 0.2 0.3 11.2 0.2 2.0 1 0 0 1 1 1 0 Cation transport ATPase (P-type) DRMBL PF07522.14 KOH00646.1 - 0.043 14.0 0.1 0.072 13.3 0.1 1.3 1 0 0 1 1 1 0 DNA repair metallo-beta-lactamase Rieske PF00355.26 KOH00647.1 - 0.055 13.4 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain Iso_dh PF00180.20 KOH00648.1 - 1.5e-125 419.0 0.0 1.7e-125 418.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DNA_ligase_aden PF01653.18 KOH00648.1 - 0.081 12.0 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent DNA ligase adenylation domain Aminotran_5 PF00266.19 KOH00649.1 - 3.2e-103 345.6 0.0 4e-103 345.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 KOH00649.1 - 3.9e-08 32.9 0.0 8.8e-08 31.7 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KOH00649.1 - 6e-08 32.3 0.0 7.8e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 KOH00649.1 - 1.5e-06 27.8 0.1 3.4e-06 26.6 0.1 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 KOH00649.1 - 8.3e-05 21.5 0.0 0.00014 20.7 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.20 KOH00649.1 - 0.00098 17.8 0.2 0.0015 17.1 0.2 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Dcc1 PF09724.9 KOH00650.1 - 3.2e-80 269.9 1.2 3.7e-80 269.7 1.2 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 DUF3507 PF12015.8 KOH00651.1 - 4.5e-70 235.1 0.0 8.4e-70 234.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) DUF2015 PF09435.10 KOH00652.1 - 3.4e-34 117.0 0.2 4e-34 116.8 0.2 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) RRM_1 PF00076.22 KOH00653.1 - 1e-57 191.9 0.1 1.7e-19 69.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOH00653.1 - 0.0018 17.8 0.0 0.7 9.5 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 KOH00653.1 - 0.0042 16.9 0.2 1.8 8.4 0.0 2.5 3 0 0 3 3 3 2 Rrp7 RRM-like N-terminal domain Importin_rep_6 PF18829.1 KOH00653.1 - 4 7.6 6.4 0.88 9.7 1.3 2.3 2 0 0 2 2 2 0 Importin repeat 6 DUF1325 PF07039.11 KOH00654.1 - 3.4e-35 121.0 0.0 1.1e-34 119.4 0.0 1.8 3 0 0 3 3 3 1 SGF29 tudor-like domain Tudor_3 PF18115.1 KOH00654.1 - 2e-06 27.5 0.0 4.4e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain Agenet PF05641.12 KOH00654.1 - 0.0018 18.7 0.1 0.33 11.5 0.0 2.5 2 0 0 2 2 2 1 Agenet domain DUF4537 PF15057.6 KOH00654.1 - 0.008 16.2 0.0 0.039 14.0 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4537) DASH_Spc19 PF08287.11 KOH00654.1 - 0.04 13.8 0.9 0.057 13.3 0.9 1.1 1 0 0 1 1 1 0 Spc19 LBR_tudor PF09465.10 KOH00654.1 - 0.14 12.0 0.0 5.4 6.9 0.0 2.5 2 0 0 2 2 2 0 Lamin-B receptor of TUDOR domain ALS_ss_C PF10369.9 KOH00655.1 - 8.6e-16 57.9 0.0 4.6e-15 55.6 0.0 2.2 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 KOH00655.1 - 1.3e-13 50.4 0.1 2.6e-13 49.5 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 KOH00655.1 - 5.6e-08 32.5 0.0 1.1e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 ACT domain Limkain-b1 PF11608.8 KOH00655.1 - 0.00069 19.6 0.3 0.0047 17.0 0.0 2.4 3 0 0 3 3 3 1 Limkain b1 ACT_4 PF13291.6 KOH00655.1 - 0.09 13.4 0.1 0.83 10.3 0.0 2.2 2 0 0 2 2 2 0 ACT domain UEV PF05743.13 KOH00656.1 - 6.4e-26 90.6 0.0 1.3e-25 89.6 0.0 1.5 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 KOH00656.1 - 4.6e-24 84.1 1.9 1.7e-23 82.3 0.1 2.5 3 0 0 3 3 3 1 Vps23 core domain UQ_con PF00179.26 KOH00656.1 - 1e-06 28.5 0.3 2.5e-06 27.2 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SRA1 PF07304.11 KOH00656.1 - 0.024 14.4 0.2 0.056 13.2 0.2 1.6 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) ZapD PF07072.11 KOH00656.1 - 0.11 12.3 2.6 0.18 11.5 2.6 1.3 1 0 0 1 1 1 0 Cell division protein Peptidase_M9_N PF08453.10 KOH00656.1 - 0.15 11.7 2.4 0.54 10.0 1.0 2.0 1 1 1 2 2 2 0 Peptidase family M9 N-terminal ATP_synt_H PF05493.13 KOH00657.1 - 1.6e-16 60.5 1.2 1.7e-16 60.4 1.2 1.0 1 0 0 1 1 1 1 ATP synthase subunit H DUF3471 PF11954.8 KOH00658.1 - 0.057 13.9 0.1 0.09 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3471) PLDc_2 PF13091.6 KOH00659.1 - 6.9e-15 55.1 0.1 6.6e-06 26.0 0.1 2.9 2 2 1 3 3 3 2 PLD-like domain PLDc PF00614.22 KOH00659.1 - 3.5e-12 46.0 1.5 4.9e-07 29.7 0.2 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif PQ-loop PF04193.14 KOH00660.1 - 0.0067 16.2 1.2 0.0067 16.2 1.2 2.4 2 1 0 2 2 2 1 PQ loop repeat Rer1 PF03248.13 KOH00661.1 - 2.1e-75 252.2 4.7 2.4e-75 252.0 4.7 1.0 1 0 0 1 1 1 1 Rer1 family DUF4395 PF14340.6 KOH00661.1 - 0.023 15.0 1.8 4.6 7.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4395) DUF2208 PF09973.9 KOH00661.1 - 0.19 11.3 5.3 0.063 12.9 2.2 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) eRF1_3 PF03465.15 KOH00662.1 - 2.6e-26 92.3 0.1 6.5e-26 91.0 0.1 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 KOH00662.1 - 3.3e-26 92.2 0.1 6.5e-26 91.2 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_1 PF03463.15 KOH00662.1 - 7.9e-22 77.6 0.9 1.3e-21 76.9 0.9 1.4 1 0 0 1 1 1 1 eRF1 domain 1 UPF0515 PF15135.6 KOH00662.1 - 0.57 9.5 1.7 0.41 9.9 0.1 1.5 2 0 0 2 2 2 0 Uncharacterised protein UPF0515 Septin PF00735.18 KOH00663.1 - 1.2e-106 356.1 0.9 1.5e-106 355.8 0.9 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KOH00663.1 - 5.6e-10 39.3 0.1 1.1e-09 38.4 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOH00663.1 - 1.5e-07 31.5 0.3 6.5e-07 29.4 0.1 2.0 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 KOH00663.1 - 2.4e-07 30.5 0.3 2.2e-05 24.1 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 KOH00663.1 - 8e-07 28.6 0.3 2.5e-06 27.0 0.3 1.8 1 1 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 KOH00663.1 - 0.00053 20.1 1.0 0.15 12.1 0.3 2.5 1 1 1 2 2 2 1 Dynamin family Gtr1_RagA PF04670.12 KOH00663.1 - 0.00091 18.7 0.5 0.009 15.4 0.5 2.1 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region FtsK_SpoIIIE PF01580.18 KOH00663.1 - 0.0015 17.9 0.1 0.0027 17.1 0.1 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family NB-ARC PF00931.22 KOH00663.1 - 0.0016 17.7 0.1 0.0024 17.1 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 KOH00663.1 - 0.0018 18.7 0.1 0.0035 17.7 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOH00663.1 - 0.0032 17.7 0.1 0.0083 16.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 KOH00663.1 - 0.0059 17.1 1.1 0.018 15.5 0.6 2.1 2 1 0 2 2 2 1 ABC transporter IIGP PF05049.13 KOH00663.1 - 0.0085 15.2 0.3 0.018 14.1 0.2 1.6 1 1 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Roc PF08477.13 KOH00663.1 - 0.011 16.0 0.0 0.023 14.9 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 KOH00663.1 - 0.014 14.9 1.2 1.1 8.8 0.1 2.4 1 1 0 2 2 2 0 Ferrous iron transport protein B AAA_29 PF13555.6 KOH00663.1 - 0.015 15.0 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 KOH00663.1 - 0.017 14.9 0.6 0.044 13.5 0.2 1.9 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.6 KOH00663.1 - 0.019 15.0 0.0 0.11 12.5 0.0 2.2 1 1 1 2 2 2 0 AAA domain AAA_7 PF12775.7 KOH00663.1 - 0.022 14.3 0.1 0.047 13.2 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 KOH00663.1 - 0.041 13.6 0.2 1.1 9.0 0.2 2.4 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.20 KOH00663.1 - 0.059 12.5 0.7 0.62 9.2 0.1 2.2 2 1 0 2 2 2 0 G-protein alpha subunit Reprolysin_3 PF13582.6 KOH00663.1 - 0.12 12.8 0.1 0.29 11.7 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Ribosomal_L32p PF01783.23 KOH00664.1 - 5.9e-12 45.7 5.8 9.8e-12 44.9 5.8 1.4 1 0 0 1 1 1 1 Ribosomal L32p protein family zf-ribbon_3 PF13248.6 KOH00664.1 - 0.042 13.3 1.9 0.077 12.4 1.9 1.4 1 0 0 1 1 1 0 zinc-ribbon domain CitMHS_2 PF16980.5 KOH00664.1 - 0.069 11.8 0.0 0.094 11.4 0.0 1.2 1 0 0 1 1 1 0 Putative citrate transport RecR PF02132.15 KOH00664.1 - 0.2 11.2 0.8 0.37 10.4 0.8 1.4 1 0 0 1 1 1 0 RecR protein FMN_red PF03358.15 KOH00665.1 - 7.6e-09 35.5 0.0 1.2e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 KOH00665.1 - 2.4e-05 24.2 0.0 4.2e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 KOH00665.1 - 0.00012 22.3 0.1 0.00028 21.1 0.1 1.6 1 1 0 1 1 1 1 Flavodoxin Citrate_synt PF00285.21 KOH00666.1 - 4.8e-104 348.3 0.0 5.9e-104 348.0 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DUF4668 PF15701.5 KOH00667.1 - 3.7e-46 156.9 13.4 4.5e-46 156.6 13.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4668) DUF1129 PF06570.11 KOH00667.1 - 0.058 12.9 2.1 0.12 11.9 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Pkinase PF00069.25 KOH00668.1 - 6e-49 166.8 0.0 1.1e-48 166.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00668.1 - 3.4e-27 95.4 0.0 5.3e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOH00668.1 - 0.0022 17.4 0.0 0.0046 16.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOH00668.1 - 0.02 14.2 0.1 0.036 13.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOH00668.1 - 0.022 14.7 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 KOH00668.1 - 0.039 13.5 0.1 0.088 12.4 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 KOH00668.1 - 0.27 10.8 0.8 0.84 9.2 0.0 2.1 3 0 0 3 3 3 0 RIO1 family BAR PF03114.18 KOH00669.1 - 8.8e-58 195.8 1.8 1e-57 195.5 1.8 1.0 1 0 0 1 1 1 1 BAR domain DUF1496 PF07383.12 KOH00669.1 - 0.0037 16.8 0.5 0.0074 15.9 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1496) DUF4164 PF13747.6 KOH00669.1 - 0.055 13.8 0.9 0.055 13.8 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) HAUS-augmin3 PF14932.6 KOH00669.1 - 0.073 12.6 1.8 0.24 11.0 0.3 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Seryl_tRNA_N PF02403.22 KOH00669.1 - 0.11 12.8 4.2 3.5 7.9 1.1 2.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Jnk-SapK_ap_N PF09744.9 KOH00669.1 - 0.2 11.9 5.9 0.15 12.3 2.4 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 BRE1 PF08647.11 KOH00669.1 - 2 8.5 7.5 26 5.0 0.1 2.4 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Gpr1_Fun34_YaaH PF01184.19 KOH00670.1 - 6.7e-95 316.6 19.0 7.9e-95 316.3 19.0 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family ABC2_membrane PF01061.24 KOH00671.1 - 1.9e-38 132.0 20.8 1.9e-38 132.0 20.8 2.0 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 KOH00671.1 - 2.5e-29 102.5 0.1 6.7e-29 101.2 0.0 1.8 2 0 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 KOH00671.1 - 0.00032 20.6 0.1 0.00072 19.5 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 KOH00671.1 - 0.0092 15.8 3.2 1 9.1 0.2 2.7 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOH00671.1 - 0.016 14.9 0.3 0.038 13.7 0.3 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 KOH00671.1 - 0.031 14.2 0.0 0.066 13.1 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_22 PF13401.6 KOH00671.1 - 0.035 14.4 0.0 0.096 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KOH00671.1 - 0.093 13.0 0.4 0.17 12.1 0.4 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOH00671.1 - 0.1 13.0 0.4 0.51 10.7 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain NACHT PF05729.12 KOH00671.1 - 0.16 11.8 0.5 0.3 11.0 0.5 1.4 1 0 0 1 1 1 0 NACHT domain ABC_ATPase PF09818.9 KOH00671.1 - 0.2 10.4 0.2 0.31 9.8 0.2 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class Laminin_EGF PF00053.24 KOH00671.1 - 0.24 11.6 32.5 0.033 14.3 5.3 4.1 4 0 0 4 4 4 0 Laminin EGF domain EGF_2 PF07974.13 KOH00671.1 - 0.36 11.2 25.2 0.061 13.7 6.4 3.7 3 0 0 3 3 3 0 EGF-like domain AAA_23 PF13476.6 KOH00671.1 - 1.9 8.9 7.9 0.57 10.6 0.6 2.5 2 1 0 2 2 2 0 AAA domain PGK PF00162.19 KOH00672.1 - 2.9e-150 500.4 0.2 3.3e-150 500.3 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Peptidase_S51 PF03575.17 KOH00672.1 - 0.064 12.9 0.3 0.83 9.3 0.1 2.3 2 0 0 2 2 2 0 Peptidase family S51 DNA_pol_B_thumb PF14791.6 KOH00673.1 - 1.9e-16 60.0 1.6 7.5e-16 58.1 0.1 2.6 3 0 0 3 3 3 1 DNA polymerase beta thumb HHH_8 PF14716.6 KOH00673.1 - 1.2e-14 54.4 0.1 3.7e-14 52.8 0.2 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_palm PF14792.6 KOH00673.1 - 8.3e-13 48.5 0.0 3.4e-12 46.6 0.0 2.1 1 1 0 1 1 1 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 KOH00673.1 - 2.6e-05 23.9 0.0 0.00011 22.0 0.0 2.2 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HAD PF12710.7 KOH00674.1 - 8.7e-11 42.6 0.0 5.8e-09 36.6 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase LNS2 PF08235.13 KOH00674.1 - 0.0098 15.4 0.2 0.017 14.6 0.2 1.5 1 1 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) DUF2373 PF10180.9 KOH00675.1 - 8.1e-27 92.9 0.8 1.8e-26 91.8 0.8 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) DDE_Tnp_1_assoc PF13808.6 KOH00675.1 - 0.048 13.7 0.1 0.37 10.9 0.0 2.3 2 1 0 2 2 2 0 DDE_Tnp_1-associated Trnau1ap PF17654.1 KOH00675.1 - 0.45 11.4 9.6 0.13 13.1 5.5 2.1 2 0 0 2 2 2 0 Selenocysteine tRNA 1 associated proteins Frag1 PF10277.9 KOH00676.1 - 2.8e-30 105.5 12.9 2.8e-30 105.5 12.9 3.8 3 3 0 3 3 3 1 Frag1/DRAM/Sfk1 family Exo_endo_phos PF03372.23 KOH00676.1 - 0.011 15.2 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family PfkB PF00294.24 KOH00677.1 - 6.1e-09 35.6 0.0 8.5e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase TENA_THI-4 PF03070.16 KOH00678.1 - 8.5e-10 38.8 0.2 1.3e-09 38.2 0.2 1.3 1 0 0 1 1 1 1 TENA/THI-4/PQQC family Sterile PF03015.19 KOH00678.1 - 0.016 15.4 0.0 0.041 14.1 0.0 1.7 1 0 0 1 1 1 0 Male sterility protein LSM PF01423.22 KOH00679.1 - 3.4e-12 45.9 0.1 4.1e-12 45.6 0.1 1.1 1 0 0 1 1 1 1 LSM domain Bac_rhodopsin PF01036.18 KOH00681.1 - 5.1e-57 193.0 18.2 6.4e-57 192.7 18.2 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF4131 PF13567.6 KOH00681.1 - 0.029 14.0 10.5 0.048 13.3 1.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) CrgA PF06781.12 KOH00681.1 - 1.3 9.1 4.3 0.94 9.6 0.2 2.4 2 0 0 2 2 2 0 Cell division protein CrgA MFS_1 PF07690.16 KOH00682.1 - 1.5e-31 109.6 1.5 3.5e-31 108.4 1.5 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOH00682.1 - 5.4e-10 38.7 2.9 5.4e-10 38.7 2.9 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter DUF5521 PF17659.1 KOH00682.1 - 0.029 12.3 0.0 0.041 11.7 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5521) TRI12 PF06609.13 KOH00682.1 - 0.23 9.8 4.9 0.024 13.1 0.4 1.5 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) tRNA-synt_2 PF00152.20 KOH00683.1 - 1.2e-80 271.0 0.0 1.6e-80 270.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOH00683.1 - 2e-08 34.1 0.0 3.5e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain FBA PF04300.13 KOH00683.1 - 0.0079 15.9 0.7 0.014 15.1 0.7 1.3 1 0 0 1 1 1 1 F-box associated region PMP1_2 PF08114.11 KOH00684.1 - 6.8e-26 89.7 3.2 7.2e-26 89.6 3.2 1.0 1 0 0 1 1 1 1 ATPase proteolipid family CD34_antigen PF06365.12 KOH00684.1 - 0.031 13.8 0.3 0.031 13.8 0.3 1.0 1 0 0 1 1 1 0 CD34/Podocalyxin family Vpu PF00558.19 KOH00684.1 - 0.071 12.9 0.6 0.07 12.9 0.6 1.0 1 0 0 1 1 1 0 Vpu protein Phosphodiest PF01663.22 KOH00685.1 - 1.8e-91 307.4 4.4 1.8e-91 307.4 4.4 1.5 2 0 0 2 2 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KOH00685.1 - 0.00041 19.8 0.0 0.002 17.6 0.0 2.1 1 1 0 1 1 1 1 Sulfatase BUD22 PF09073.10 KOH00685.1 - 0.058 12.7 3.1 0.09 12.1 3.1 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 KOH00685.1 - 0.09 12.2 3.4 0.13 11.6 3.4 1.3 1 0 0 1 1 1 0 SDA1 PglZ PF08665.12 KOH00685.1 - 0.14 12.3 0.1 0.45 10.6 0.0 1.9 2 0 0 2 2 2 0 PglZ domain CDC45 PF02724.14 KOH00685.1 - 0.26 9.5 1.9 0.45 8.8 1.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 KOH00685.1 - 0.36 9.0 7.2 0.59 8.3 7.2 1.2 1 0 0 1 1 1 0 Nop14-like family Sporozoite_P67 PF05642.11 KOH00685.1 - 0.54 8.3 7.3 0.99 7.4 7.3 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PI3K_1B_p101 PF10486.9 KOH00685.1 - 0.9 7.2 3.7 1.3 6.7 3.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit NOA36 PF06524.12 KOH00685.1 - 0.93 8.8 14.3 1.5 8.1 14.3 1.3 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 KOH00685.1 - 1 8.5 16.2 1.7 7.7 16.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RXT2_N PF08595.11 KOH00685.1 - 1 9.3 7.4 0.25 11.4 3.5 1.9 2 0 0 2 2 2 0 RXT2-like, N-terminal RRN3 PF05327.11 KOH00685.1 - 1.3 7.5 3.6 1.8 7.0 3.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Cwf_Cwc_15 PF04889.12 KOH00685.1 - 1.9 8.1 12.1 3.6 7.3 12.1 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Ras PF00071.22 KOH00686.1 - 7.2e-47 159.0 0.1 8.6e-47 158.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOH00686.1 - 3e-15 56.5 0.0 5.4e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOH00686.1 - 6.5e-08 32.2 0.0 7.7e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOH00686.1 - 4.6e-05 23.5 0.0 7.5e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_14 PF13173.6 KOH00686.1 - 0.0021 18.1 0.1 0.011 15.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain SRPRB PF09439.10 KOH00686.1 - 0.004 16.6 0.1 0.0057 16.1 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 KOH00686.1 - 0.013 15.0 0.3 0.63 9.6 0.3 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KOH00686.1 - 0.035 13.6 0.0 0.056 13.0 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B DUF1904 PF08921.11 KOH00686.1 - 0.065 13.5 0.0 0.17 12.2 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1904) AAA_28 PF13521.6 KOH00686.1 - 0.092 13.0 0.0 0.21 11.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 KOH00686.1 - 0.1 12.5 1.5 1 9.2 1.5 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea MFS_1 PF07690.16 KOH00687.1 - 3.9e-21 75.4 28.1 6e-21 74.8 28.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 KOH00687.1 - 1.5e-05 24.5 5.4 1.9e-05 24.1 0.4 2.3 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DDDD PF10161.9 KOH00687.1 - 0.00014 21.6 0.6 0.0012 18.5 0.1 2.6 3 0 0 3 3 3 1 Putative mitochondrial precursor protein DUF3792 PF12670.7 KOH00687.1 - 0.15 12.2 9.3 0.062 13.5 1.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3792) DNA_pol_phi PF04931.13 KOH00687.1 - 0.31 9.1 2.5 0.44 8.6 2.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF3147 PF11345.8 KOH00687.1 - 2.5 8.5 10.2 0.87 10.0 0.2 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3147) muHD PF10291.9 KOH00688.1 - 5.9e-79 265.2 0.0 1.1e-78 264.4 0.0 1.4 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain SRP40_C PF05022.12 KOH00688.1 - 0.016 16.1 2.7 0.017 16.0 0.7 2.1 2 0 0 2 2 2 0 SRP40, C-terminal domain FCH PF00611.23 KOH00688.1 - 0.22 11.9 3.8 0.084 13.2 0.5 2.0 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Ribosomal_S11 PF00411.19 KOH00689.1 - 9.2e-46 154.8 2.2 1.1e-45 154.5 2.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 BKACE PF05853.12 KOH00689.1 - 0.084 12.2 0.3 0.1 11.9 0.3 1.1 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme Beach PF02138.18 KOH00690.1 - 1.2e-116 388.9 1.3 1.5e-116 388.6 0.0 1.8 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.6 KOH00690.1 - 7.9e-12 45.2 2.5 4.7e-10 39.5 0.0 2.9 2 0 0 2 2 2 2 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 KOH00690.1 - 0.0028 17.8 0.0 0.0069 16.5 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Myb_DNA-binding PF00249.31 KOH00691.1 - 3e-16 59.3 0.0 5.2e-08 32.9 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOH00691.1 - 7.7e-06 26.1 0.2 0.014 15.6 0.1 3.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOH00691.1 - 0.0015 18.4 0.2 0.0015 18.4 0.2 3.8 3 1 1 4 4 4 1 Myb DNA-binding like ELO PF01151.18 KOH00692.1 - 2.8e-60 204.0 25.6 3.3e-60 203.7 25.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family RNase_PH PF01138.21 KOH00693.1 - 5.4e-26 91.7 0.9 8.8e-25 87.7 0.5 2.8 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 PfkB PF00294.24 KOH00694.1 - 6e-46 157.1 3.1 5.4e-45 154.0 3.1 2.0 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 KOH00694.1 - 0.039 13.3 0.1 1.9 7.8 0.0 2.5 3 0 0 3 3 3 0 Phosphomethylpyrimidine kinase RasGEF PF00617.19 KOH00695.1 - 9e-30 104.2 2.6 9e-30 104.2 2.6 2.3 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 KOH00695.1 - 0.068 13.4 3.6 0.093 13.0 1.2 2.5 2 1 0 2 2 2 0 RasGEF N-terminal motif Glycoprotein_G PF00802.19 KOH00695.1 - 0.16 11.3 4.6 0.66 9.3 0.6 2.3 2 0 0 2 2 2 0 Pneumovirus attachment glycoprotein G AAA_lid_1 PF17857.1 KOH00695.1 - 0.87 9.8 5.0 13 6.1 0.2 3.4 3 0 0 3 3 3 0 AAA+ lid domain Homeodomain PF00046.29 KOH00696.1 - 4.4e-09 36.0 1.2 4.4e-09 36.0 1.2 1.8 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KOH00696.1 - 7.6e-07 28.9 0.5 7.6e-07 28.9 0.5 2.2 2 0 0 2 2 2 1 Homeobox KN domain GCIP PF13324.6 KOH00696.1 - 0.013 15.1 1.3 0.023 14.3 1.3 1.4 1 1 0 1 1 1 0 Grap2 and cyclin-D-interacting Homez PF11569.8 KOH00696.1 - 0.039 13.4 0.1 0.44 10.0 0.0 2.2 1 1 1 2 2 2 0 Homeodomain leucine-zipper encoding, Homez MATalpha_HMGbox PF04769.12 KOH00697.1 - 4.7e-15 55.4 0.4 6.2e-15 55.1 0.4 1.1 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box Peptidase_M1_N PF17900.1 KOH00698.1 - 1.8e-05 25.0 0.2 0.4 10.8 0.3 2.8 1 1 1 2 2 2 2 Peptidase M1 N-terminal domain BUD22 PF09073.10 KOH00698.1 - 0.0021 17.5 9.3 0.0039 16.6 9.3 1.4 1 0 0 1 1 1 1 BUD22 Peptidase_M1 PF01433.20 KOH00698.1 - 0.02 14.5 0.0 0.15 11.6 0.0 2.2 2 0 0 2 2 2 0 Peptidase family M1 domain SDA1 PF05285.12 KOH00698.1 - 0.45 9.9 20.8 0.84 9.0 20.8 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 KOH00698.1 - 5.4 5.1 21.0 8.4 4.5 21.0 1.2 1 0 0 1 1 1 0 Nop14-like family Per1 PF04080.13 KOH00700.1 - 9.7e-87 290.9 19.0 1.5e-86 290.3 19.0 1.3 1 0 0 1 1 1 1 Per1-like family Peptidase_S8 PF00082.22 KOH00701.1 - 2.6e-27 95.9 1.5 2.5e-26 92.6 1.5 2.0 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 KOH00701.1 - 0.0078 16.9 0.0 0.018 15.7 0.0 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 Ribosomal_L19 PF01245.20 KOH00702.1 - 8.3e-09 35.4 0.0 1.3e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L19 DUF3221 PF11518.8 KOH00702.1 - 0.085 13.2 0.0 0.35 11.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3221) WBS_methylT PF12589.8 KOH00703.1 - 2.6e-13 50.5 4.6 2.6e-13 50.5 4.6 1.6 2 0 0 2 2 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 KOH00703.1 - 3.4e-12 46.8 0.0 7.3e-12 45.8 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOH00703.1 - 2e-11 44.5 0.0 7.2e-11 42.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOH00703.1 - 7.9e-07 29.8 0.0 5e-06 27.2 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 KOH00703.1 - 2.7e-05 23.6 0.1 0.00025 20.4 0.0 2.3 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 KOH00703.1 - 0.00038 20.3 0.0 0.00088 19.1 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KOH00703.1 - 0.00059 19.6 0.0 0.0043 16.9 0.0 2.2 1 1 0 2 2 2 1 Methyltransferase domain MetW PF07021.12 KOH00703.1 - 0.0013 18.4 0.0 0.0023 17.5 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_23 PF13489.6 KOH00703.1 - 0.0018 18.1 0.0 0.0032 17.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOH00703.1 - 0.0051 16.8 0.2 0.48 10.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 KOH00703.1 - 0.0052 16.2 0.3 0.021 14.2 0.1 2.0 3 0 0 3 3 3 1 Ribosomal protein L11 methyltransferase (PrmA) AdoMet_MTase PF07757.13 KOH00703.1 - 0.13 12.6 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase MBOAT PF03062.19 KOH00704.1 - 1.5e-85 287.6 39.6 2.1e-85 287.2 39.6 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF4698 PF15769.5 KOH00704.1 - 0.05 12.7 1.5 0.073 12.1 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Ank_5 PF13857.6 KOH00705.1 - 2.4e-14 53.2 0.6 1e-10 41.6 0.2 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOH00705.1 - 6.3e-09 36.3 0.1 2.3e-08 34.5 0.1 1.9 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOH00705.1 - 5.6e-08 33.2 0.1 0.0013 19.2 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOH00705.1 - 3.6e-07 30.0 0.2 0.00046 20.4 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 KOH00705.1 - 4.3e-07 30.1 1.7 0.0019 18.6 0.4 3.0 3 0 0 3 3 3 2 Ankyrin repeat Inositol_P PF00459.25 KOH00705.1 - 0.0087 15.6 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 Inositol monophosphatase family SWIB PF02201.18 KOH00706.1 - 8.6e-06 25.5 0.1 0.0003 20.6 0.0 2.7 2 0 0 2 2 2 1 SWIB/MDM2 domain RXT2_N PF08595.11 KOH00706.1 - 0.65 10.0 15.4 0.19 11.8 1.3 3.0 3 0 0 3 3 3 0 RXT2-like, N-terminal TT_ORF2 PF02957.15 KOH00706.1 - 3.4 8.6 7.3 27 5.7 0.2 2.7 2 0 0 2 2 2 0 TT viral ORF2 Cwf_Cwc_15 PF04889.12 KOH00706.1 - 4.5 6.9 23.8 1.9 8.1 3.9 3.4 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein Thr_synth_N PF14821.6 KOH00707.1 - 7.7e-29 99.7 0.0 2.8e-28 97.9 0.0 2.1 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 KOH00707.1 - 3.9e-11 42.9 0.0 9.4e-11 41.7 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Atx10homo_assoc PF09759.9 KOH00708.1 - 2.5e-36 123.7 1.4 8.8e-36 121.9 0.3 2.3 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain WD40 PF00400.32 KOH00709.1 - 2.2e-46 154.9 14.0 1.5e-08 35.2 0.1 13.1 14 0 0 14 14 13 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00709.1 - 5e-32 110.1 0.0 0.00084 19.6 0.0 9.2 4 2 7 11 11 11 8 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 KOH00709.1 - 7.8e-23 80.8 0.0 1.4e-22 80.0 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family eIF2A PF08662.11 KOH00709.1 - 2.5e-10 40.6 7.3 0.00042 20.3 0.0 6.6 5 3 3 8 8 8 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOH00709.1 - 6.9e-07 28.5 6.4 0.14 11.1 0.0 6.7 4 3 3 7 7 7 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 KOH00709.1 - 3.2e-06 26.7 0.7 0.084 12.2 0.1 4.0 3 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 KOH00709.1 - 2.3e-05 23.9 1.5 1.5 8.0 0.0 5.1 5 1 1 6 6 6 1 WD40-like domain Cytochrom_D1 PF02239.16 KOH00709.1 - 0.00019 20.1 0.5 0.26 9.8 0.0 4.1 4 1 0 4 4 4 2 Cytochrome D1 heme domain Nup160 PF11715.8 KOH00709.1 - 0.002 16.8 4.9 0.19 10.3 0.0 4.2 3 2 2 5 5 5 1 Nucleoporin Nup120/160 WD40_3 PF15911.5 KOH00709.1 - 0.0027 17.7 0.0 0.015 15.3 0.0 2.3 1 0 0 1 1 1 1 WD domain, G-beta repeat PD40 PF07676.12 KOH00709.1 - 0.0072 16.2 0.1 47 4.1 0.0 4.4 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat CPSF_A PF03178.15 KOH00709.1 - 0.084 12.2 0.1 0.7 9.1 0.0 2.4 2 0 0 2 2 2 0 CPSF A subunit region Proteasome_A_N PF10584.9 KOH00709.1 - 1.2 8.9 3.6 4.9 6.9 0.0 3.8 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature UPF0029 PF01205.19 KOH00710.1 - 2e-31 108.5 0.1 3.4e-31 107.7 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 KOH00710.1 - 2.4e-08 34.3 0.1 6e-08 33.0 0.1 1.7 1 1 0 1 1 1 1 RWD domain TPR_1 PF00515.28 KOH00711.1 - 8.8e-11 41.2 0.7 0.00016 21.3 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOH00711.1 - 1.5e-09 37.3 4.1 0.00035 20.4 0.3 2.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOH00711.1 - 1.8e-07 31.7 0.6 1.8e-07 31.7 0.6 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOH00711.1 - 1.9e-07 31.3 4.1 0.011 16.5 0.0 2.6 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOH00711.1 - 4.4e-07 29.5 0.7 3.2e-06 26.7 0.2 2.1 1 1 1 2 2 2 1 TPR repeat TPR_19 PF14559.6 KOH00711.1 - 1.3e-06 28.8 3.6 1.3e-06 28.8 3.6 1.4 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOH00711.1 - 6.4e-06 25.8 0.4 0.066 13.3 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOH00711.1 - 3e-05 23.9 1.0 0.0086 16.2 0.0 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOH00711.1 - 3.5e-05 23.8 1.4 0.057 13.5 0.1 2.3 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 KOH00711.1 - 0.00041 20.5 1.0 0.00054 20.1 1.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KOH00711.1 - 0.00062 20.0 0.5 0.0019 18.4 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOH00711.1 - 0.00088 19.4 1.2 0.00088 19.4 1.2 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOH00711.1 - 0.0014 19.1 4.0 0.29 11.8 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOH00711.1 - 0.0021 18.3 4.9 0.11 12.8 1.3 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_4 PF07721.14 KOH00711.1 - 0.0069 16.9 2.6 0.027 15.1 0.0 2.9 3 1 0 3 3 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOH00711.1 - 1 9.3 6.2 1.7 8.6 0.2 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Ytp1 PF10355.9 KOH00712.1 - 4.6e-110 367.2 11.6 6.2e-110 366.8 11.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 KOH00712.1 - 7.3e-28 96.4 3.2 7.3e-28 96.4 3.2 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) DUF3246 PF11596.8 KOH00712.1 - 0.12 11.8 3.2 0.23 10.8 2.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) G10 PF01125.17 KOH00714.1 - 9.8e-64 213.5 7.6 1.1e-63 213.3 7.6 1.0 1 0 0 1 1 1 1 G10 protein Forkhead PF00250.18 KOH00715.1 - 4.6e-34 116.5 0.3 1.6e-33 114.8 0.2 2.0 2 0 0 2 2 2 1 Forkhead domain Voldacs PF03517.13 KOH00715.1 - 0.32 11.1 4.2 0.68 10.0 4.2 1.5 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling zf-C3HC4_2 PF13923.6 KOH00716.1 - 2.5e-11 43.2 16.8 6.4e-11 41.9 12.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOH00716.1 - 1.7e-10 40.6 12.9 1.7e-10 40.6 12.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOH00716.1 - 1.9e-08 34.2 17.0 2.8e-07 30.4 11.8 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KOH00716.1 - 1.1e-07 31.6 13.1 6.1e-07 29.2 7.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SAP PF02037.27 KOH00716.1 - 2e-06 27.4 0.0 5.4e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 SAP domain zf-RING_2 PF13639.6 KOH00716.1 - 2.2e-06 27.9 17.1 5.6e-06 26.6 11.5 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 KOH00716.1 - 3.6e-06 26.8 17.4 3.8e-05 23.6 10.7 2.4 2 0 0 2 2 2 2 zinc-RING finger domain zf-RING_6 PF14835.6 KOH00716.1 - 3.7e-06 26.7 4.1 8.5e-06 25.6 4.1 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 KOH00716.1 - 5.8e-06 26.4 16.0 6.5e-06 26.2 11.6 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 KOH00716.1 - 3.1e-05 23.7 16.4 0.00016 21.4 9.6 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 U-box PF04564.15 KOH00716.1 - 0.00024 21.2 0.0 0.0019 18.3 0.0 2.4 2 0 0 2 2 2 1 U-box domain zf-rbx1 PF12678.7 KOH00716.1 - 0.00069 19.9 7.1 0.00069 19.9 7.1 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_10 PF16685.5 KOH00716.1 - 0.0016 18.6 4.1 0.0016 18.6 4.1 2.0 2 0 0 2 2 2 1 zinc RING finger of MSL2 Baculo_IE-1 PF05290.11 KOH00716.1 - 0.033 14.1 1.4 0.033 14.1 1.4 2.5 3 0 0 3 3 3 0 Baculovirus immediate-early protein (IE-0) GAGA PF09237.11 KOH00716.1 - 0.037 13.8 0.8 0.037 13.8 0.8 2.4 2 0 0 2 2 2 0 GAGA factor Mob_synth_C PF06463.13 KOH00716.1 - 0.097 12.6 0.8 0.29 11.0 0.8 1.8 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C zf-RING_4 PF14570.6 KOH00716.1 - 0.16 11.8 7.7 0.56 10.0 2.6 2.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain HAD_2 PF13419.6 KOH00716.1 - 0.32 11.1 3.7 0.2 11.7 0.3 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase zf-WRNIP1_ubi PF18279.1 KOH00716.1 - 0.89 10.3 6.9 0.14 12.8 0.9 2.7 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain XAF1_C PF18608.1 KOH00716.1 - 1.8 8.2 8.9 0.9 9.2 0.6 2.9 3 0 0 3 3 3 0 XIAP-associated factor 1 C-terminal domain zf-ANAPC11 PF12861.7 KOH00716.1 - 2.6 8.1 6.3 12 6.1 2.6 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger UBZ_FAAP20 PF15750.5 KOH00716.1 - 5.5 7.0 6.6 18 5.4 1.4 3.1 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger DUF1556 PF07590.11 KOH00717.1 - 0.37 11.1 3.5 9.9 6.5 1.3 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1556) WD40 PF00400.32 KOH00718.1 - 8.8e-07 29.5 1.1 0.037 14.9 0.0 5.1 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00718.1 - 3.6e-05 24.0 0.0 0.13 12.6 0.0 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Lipase_3 PF01764.25 KOH00719.1 - 3.1e-09 36.8 0.0 6.3e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 KOH00719.1 - 0.0076 16.9 0.0 0.014 16.0 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family UPF0227 PF05728.12 KOH00719.1 - 0.029 14.3 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Abhydrolase_1 PF00561.20 KOH00719.1 - 0.052 13.2 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Pro_isomerase PF00160.21 KOH00720.1 - 3.1e-22 79.5 0.0 5e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PROL5-SMR PF15621.6 KOH00720.1 - 0.023 15.2 0.1 3.6 8.2 0.0 2.5 2 1 0 2 2 2 0 Proline-rich submaxillary gland androgen-regulated family Img2 PF05046.14 KOH00721.1 - 7.2e-25 87.1 0.4 9.8e-25 86.7 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) SUI1 PF01253.22 KOH00721.1 - 0.091 13.3 1.6 0.43 11.2 1.6 1.9 1 1 0 1 1 1 0 Translation initiation factor SUI1 WD40 PF00400.32 KOH00722.1 - 9e-63 206.7 39.3 1.3e-12 48.0 0.2 9.3 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00722.1 - 1.6e-19 70.0 5.4 2.4e-05 24.6 0.1 5.5 3 3 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOH00722.1 - 2.1e-09 37.5 1.2 8.8e-05 22.5 0.0 3.8 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A NLE PF08154.12 KOH00722.1 - 1.4e-08 35.1 0.0 2.5e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 KOH00722.1 - 2.5e-05 23.4 0.1 0.66 8.9 0.0 4.0 4 1 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KOH00722.1 - 3.4e-05 22.7 6.8 2.1 6.9 0.0 5.6 3 1 3 6 6 6 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 KOH00722.1 - 0.0012 18.2 1.2 0.9 8.8 0.1 3.1 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 KOH00722.1 - 0.0015 17.2 0.0 0.12 10.8 0.1 2.9 2 1 0 2 2 2 1 Cytochrome D1 heme domain PD40 PF07676.12 KOH00722.1 - 0.0037 17.2 0.3 3 7.9 0.1 3.2 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 KOH00722.1 - 0.011 14.6 1.2 1.7 7.3 0.1 3.3 3 2 1 4 4 4 0 Nup133 N terminal like Wbp11 PF09429.10 KOH00722.1 - 0.089 13.2 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 WD40_like PF17005.5 KOH00722.1 - 0.096 12.0 0.0 12 5.1 0.0 3.2 4 0 0 4 4 4 0 WD40-like domain Pkinase PF00069.25 KOH00723.1 - 1.6e-63 214.5 0.0 2.6e-63 213.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00723.1 - 2e-34 119.0 0.2 7.1e-33 114.0 0.2 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOH00723.1 - 5.1e-05 22.7 0.0 0.00046 19.6 0.0 2.4 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 KOH00723.1 - 0.02 14.8 0.0 0.14 12.1 0.0 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOH00723.1 - 0.087 11.6 0.0 0.17 10.6 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase COG5 PF10392.9 KOH00723.1 - 1.2 9.3 4.2 4.1 7.6 0.0 3.4 3 1 0 3 3 3 0 Golgi transport complex subunit 5 Glucosamine_iso PF01182.20 KOH00724.1 - 1.1e-53 182.4 0.0 2.4e-53 181.3 0.0 1.5 2 0 0 2 2 2 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Tis11B_N PF04553.12 KOH00724.1 - 0.0074 16.8 1.3 0.015 15.9 1.3 1.4 1 0 0 1 1 1 1 Tis11B like protein, N terminus DUF3215 PF11503.8 KOH00725.1 - 1.4e-24 85.7 0.1 1.5e-24 85.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3215) PAD_M PF08527.10 KOH00725.1 - 0.081 12.6 0.0 0.082 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain PI31_Prot_C PF08577.11 KOH00726.1 - 3.3e-07 31.4 8.7 3.3e-07 31.4 8.7 2.1 2 0 0 2 2 2 1 PI31 proteasome regulator PP2C PF00481.21 KOH00727.1 - 8.7e-44 150.1 0.0 1.8e-43 149.0 0.0 1.5 2 0 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.6 KOH00727.1 - 2.4e-05 24.1 0.0 0.00052 19.7 0.0 2.2 2 0 0 2 2 2 1 Protein phosphatase 2C Med12 PF09497.10 KOH00728.1 - 8.2e-19 67.7 0.1 1.9e-18 66.5 0.1 1.7 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 YqzH PF14164.6 KOH00728.1 - 0.019 15.1 0.0 0.11 12.5 0.0 2.5 1 0 0 1 1 1 0 YqzH-like protein DUF4646 PF15496.6 KOH00729.1 - 0.067 13.8 0.1 0.1 13.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4646) Thioredoxin PF00085.20 KOH00730.1 - 1.2e-29 102.3 0.2 1.6e-29 101.9 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KOH00730.1 - 4.2e-05 24.0 0.2 9.3e-05 22.8 0.2 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOH00730.1 - 0.00014 22.1 0.0 0.0065 16.8 0.0 2.4 1 1 1 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.21 KOH00730.1 - 0.00029 20.7 0.0 0.00039 20.3 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KOH00730.1 - 0.0025 17.5 0.1 0.019 14.7 0.1 1.9 1 1 0 2 2 2 1 Redoxin Thioredoxin_9 PF14595.6 KOH00730.1 - 0.0026 17.5 0.0 0.0031 17.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 KOH00730.1 - 0.0095 15.7 0.2 0.18 11.6 0.1 2.1 1 1 1 2 2 2 1 DSBA-like thioredoxin domain TraF PF13728.6 KOH00730.1 - 0.016 15.0 0.0 0.021 14.7 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein Phosducin PF02114.16 KOH00730.1 - 0.022 13.7 0.0 0.025 13.5 0.0 1.1 1 0 0 1 1 1 0 Phosducin Thioredoxin_7 PF13899.6 KOH00730.1 - 0.03 14.5 0.1 0.047 13.9 0.1 1.4 1 1 0 1 1 1 0 Thioredoxin-like YedD PF13987.6 KOH00730.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 YedD-like protein OST3_OST6 PF04756.13 KOH00730.1 - 0.13 11.6 0.1 0.16 11.3 0.1 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family WD40 PF00400.32 KOH00731.1 - 3.4e-50 166.9 12.4 1e-08 35.7 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 KOH00731.1 - 2.5e-28 98.2 12.0 2.5e-28 98.2 12.0 2.4 2 0 0 2 2 2 1 Tup N-terminal ANAPC4_WD40 PF12894.7 KOH00731.1 - 7.9e-16 58.1 0.1 7e-06 26.3 0.0 5.9 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOH00731.1 - 0.00013 20.7 7.1 0.23 10.0 0.1 4.1 2 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 KOH00731.1 - 0.00021 20.7 0.2 0.39 10.0 0.0 4.3 2 1 3 5 5 5 2 WD40-like domain Ge1_WD40 PF16529.5 KOH00731.1 - 0.00038 19.5 0.2 0.86 8.5 0.0 4.0 2 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytokin-bind PF09265.10 KOH00731.1 - 0.13 11.6 3.8 0.09 12.2 1.2 1.8 2 0 0 2 2 2 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Tropomyosin_1 PF12718.7 KOH00731.1 - 0.39 10.9 14.0 0.24 11.6 11.0 2.2 1 1 0 1 1 1 0 Tropomyosin like DUF530 PF04409.12 KOH00731.1 - 8.1 4.7 9.9 4 5.7 6.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF530) Csm1_N PF18504.1 KOH00732.1 - 1.6e-25 89.2 6.4 1.6e-25 89.2 6.4 1.8 2 0 0 2 2 1 1 Csm1 N-terminal domain Csm1 PF12539.8 KOH00732.1 - 1.6e-21 76.7 0.1 2.6e-21 76.0 0.1 1.3 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 ADIP PF11559.8 KOH00732.1 - 0.00019 21.5 1.1 0.00038 20.6 1.1 1.5 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding FlxA PF14282.6 KOH00732.1 - 0.00071 19.5 4.7 0.0019 18.2 4.7 1.8 1 0 0 1 1 1 1 FlxA-like protein Tmemb_cc2 PF10267.9 KOH00732.1 - 0.0011 18.2 0.8 0.0011 18.2 0.1 1.5 2 0 0 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein ATG16 PF08614.11 KOH00732.1 - 0.0013 19.0 2.6 0.0013 19.0 2.6 1.7 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 KOH00732.1 - 0.0026 17.2 0.3 0.0027 17.1 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Syntaxin-6_N PF09177.11 KOH00732.1 - 0.0044 17.5 1.6 0.0044 17.5 1.6 1.7 2 1 0 2 2 2 1 Syntaxin 6, N-terminal DASH_Dad2 PF08654.10 KOH00732.1 - 0.0068 16.8 0.3 0.017 15.5 0.3 1.7 1 0 0 1 1 1 1 DASH complex subunit Dad2 Phage_GP20 PF06810.11 KOH00732.1 - 0.0069 16.2 2.9 0.0069 16.2 2.9 1.8 2 0 0 2 2 2 1 Phage minor structural protein GP20 ABC_tran_CTD PF16326.5 KOH00732.1 - 0.0095 16.2 0.5 0.0095 16.2 0.5 2.5 3 0 0 3 3 3 1 ABC transporter C-terminal domain TMF_DNA_bd PF12329.8 KOH00732.1 - 0.011 15.7 6.8 0.011 15.7 6.8 2.0 3 0 0 3 3 2 0 TATA element modulatory factor 1 DNA binding BRE1 PF08647.11 KOH00732.1 - 0.013 15.6 2.8 0.013 15.6 2.8 1.9 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Spc24 PF08286.11 KOH00732.1 - 0.015 15.6 1.7 0.015 15.6 1.7 1.7 2 0 0 2 2 1 0 Spc24 subunit of Ndc80 NPV_P10 PF05531.12 KOH00732.1 - 0.016 15.7 5.4 0.44 11.0 5.6 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4349 PF14257.6 KOH00732.1 - 0.018 14.5 1.5 0.033 13.7 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) DUF4315 PF14193.6 KOH00732.1 - 0.025 14.6 2.8 0.025 14.6 2.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) BLOC1_2 PF10046.9 KOH00732.1 - 0.032 14.5 2.5 0.032 14.5 2.5 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SlyX PF04102.12 KOH00732.1 - 0.033 14.8 1.6 0.072 13.7 1.6 1.7 1 0 0 1 1 1 0 SlyX FlaC_arch PF05377.11 KOH00732.1 - 0.045 14.1 4.5 0.051 14.0 3.1 1.9 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) LPP PF04728.13 KOH00732.1 - 0.05 14.0 3.0 0.24 11.8 3.1 2.1 2 0 0 2 2 2 0 Lipoprotein leucine-zipper DUF4140 PF13600.6 KOH00732.1 - 0.064 13.7 0.6 0.33 11.4 0.4 2.0 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF1454 PF07305.12 KOH00732.1 - 0.089 12.2 1.6 5.4 6.4 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1454) DUF3138 PF11336.8 KOH00732.1 - 0.1 11.2 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DivIC PF04977.15 KOH00732.1 - 0.11 12.2 9.1 0.06 13.1 4.2 2.7 2 1 1 3 3 3 0 Septum formation initiator Cauli_AT PF03233.13 KOH00732.1 - 0.12 12.3 4.6 0.074 13.0 2.1 1.8 2 0 0 2 2 2 0 Aphid transmission protein TolA_bind_tri PF16331.5 KOH00732.1 - 0.14 12.2 4.0 0.13 12.4 2.0 2.0 2 0 0 2 2 2 0 TolA binding protein trimerisation Seryl_tRNA_N PF02403.22 KOH00732.1 - 0.17 12.1 6.5 0.35 11.1 2.5 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4795 PF16043.5 KOH00732.1 - 0.19 11.3 5.4 0.16 11.6 2.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) DUF16 PF01519.16 KOH00732.1 - 0.2 12.2 4.4 0.15 12.6 2.5 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF16 Fib_alpha PF08702.10 KOH00732.1 - 0.26 11.5 8.2 0.08 13.1 5.0 1.9 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 KOH00732.1 - 0.29 11.2 3.2 0.54 10.3 3.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF724 PF05266.14 KOH00732.1 - 0.36 10.6 5.3 0.11 12.3 2.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Tup_N PF08581.10 KOH00732.1 - 5.3 7.4 9.5 0.27 11.5 3.2 2.2 3 0 0 3 3 1 0 Tup N-terminal zf-LYAR PF08790.11 KOH00733.1 - 7.7e-15 54.5 7.2 1.4e-14 53.6 7.2 1.5 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger CAP_N PF01213.19 KOH00733.1 - 0.0032 17.0 1.9 0.004 16.7 1.9 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal zf-C2H2_jaz PF12171.8 KOH00733.1 - 0.014 15.7 3.7 0.1 12.9 0.4 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding XPA_N PF01286.18 KOH00733.1 - 0.069 13.2 3.5 2 8.5 0.1 2.4 2 0 0 2 2 2 0 XPA protein N-terminal zf-C2H2_4 PF13894.6 KOH00733.1 - 0.1 13.5 5.2 1 10.4 0.2 2.6 2 1 0 2 2 2 0 C2H2-type zinc finger zf_UBZ PF18439.1 KOH00733.1 - 0.18 11.4 1.6 14 5.4 0.2 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 KOH00733.1 - 1.6 9.2 5.1 14 6.3 0.4 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 KOH00733.1 - 4.5 7.9 6.2 2 9.0 1.2 2.5 2 1 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOH00733.1 - 5.3 7.7 8.9 20 5.8 3.6 3.3 1 1 1 2 2 2 0 Zinc-finger double domain Cofilin_ADF PF00241.20 KOH00734.1 - 1.8e-21 76.1 0.0 4.8e-21 74.8 0.0 1.8 2 0 0 2 2 2 1 Cofilin/tropomyosin-type actin-binding protein SH3_1 PF00018.28 KOH00734.1 - 5.4e-15 54.7 0.9 1.3e-14 53.5 0.9 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOH00734.1 - 3.2e-13 49.3 0.2 9.1e-13 47.8 0.2 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOH00734.1 - 2.4e-06 27.1 0.0 5.2e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Anophelin PF10731.9 KOH00734.1 - 4.7 7.1 7.4 1.5 8.7 0.3 3.4 3 0 0 3 3 3 0 Thrombin inhibitor from mosquito Flocculin_t3 PF13928.6 KOH00735.1 - 1e-07 32.3 6.5 1e-07 32.3 6.5 8.1 6 2 0 6 6 6 1 Flocculin type 3 repeat Collagen PF01391.18 KOH00735.1 - 2.4 8.0 15.9 6.8 6.5 6.8 2.3 1 1 1 2 2 2 0 Collagen triple helix repeat (20 copies) Flocculin_t3 PF13928.6 KOH00736.1 - 1.5e-12 47.8 34.4 6.6e-08 32.9 12.2 15.5 7 3 3 11 11 11 3 Flocculin type 3 repeat DUF866 PF05907.13 KOH00737.1 - 1.1e-42 145.6 4.3 1.6e-42 145.1 4.3 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) zf-FLZ PF04570.14 KOH00737.1 - 0.042 13.3 0.0 0.042 13.3 0.0 2.1 3 0 0 3 3 3 0 zinc-finger of the FCS-type, C2-C2 EPL1 PF10513.9 KOH00737.1 - 0.046 14.1 0.1 0.072 13.5 0.1 1.4 1 1 0 1 1 1 0 Enhancer of polycomb-like Yippee-Mis18 PF03226.14 KOH00737.1 - 0.083 13.1 0.9 0.75 10.0 0.2 2.3 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-PHD-like PF15446.6 KOH00737.1 - 0.12 12.0 3.6 8.6 5.9 0.0 2.9 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain Elf1 PF05129.13 KOH00737.1 - 1.8 8.7 5.5 4.7 7.3 0.3 2.8 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like Pkinase PF00069.25 KOH00738.1 - 7.3e-82 274.7 0.1 1.1e-81 274.1 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00738.1 - 4.7e-33 114.6 0.1 3.7e-32 111.6 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOH00738.1 - 1.7e-12 47.3 0.1 3.4e-08 33.2 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 KOH00738.1 - 0.00053 18.9 0.0 0.0011 17.9 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOH00738.1 - 0.063 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MutS_V PF00488.21 KOH00739.1 - 7.5e-64 215.2 0.1 1.8e-63 214.0 0.0 1.7 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 KOH00739.1 - 1.2e-32 113.7 0.8 3e-32 112.4 0.8 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 KOH00739.1 - 2.4e-32 111.5 0.1 4.6e-32 110.6 0.1 1.5 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 KOH00739.1 - 8.4e-12 45.5 0.6 8.6e-11 42.3 0.0 3.1 3 2 0 3 3 3 1 MutS domain II MutS_IV PF05190.18 KOH00739.1 - 1.2e-07 32.0 1.2 4.3e-07 30.2 1.2 1.9 1 0 0 1 1 1 1 MutS family domain IV DHC_N2 PF08393.13 KOH00739.1 - 0.00037 19.7 2.4 0.0015 17.7 1.2 2.4 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_14 PF13173.6 KOH00739.1 - 0.21 11.7 1.9 1.2 9.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain Not1 PF04054.15 KOH00740.1 - 4.6e-126 420.7 7.8 4.6e-126 420.7 7.8 4.1 3 2 0 3 3 1 1 CCR4-Not complex component, Not1 CNOT1_HEAT_N PF16419.5 KOH00740.1 - 3.4e-87 291.9 3.8 3.4e-87 291.9 3.8 3.7 3 0 0 3 3 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat CNOT1_CAF1_bind PF16415.5 KOH00740.1 - 6.3e-84 280.9 6.3 6.3e-84 280.9 6.3 2.2 2 0 0 2 2 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.5 KOH00740.1 - 1.4e-41 141.8 0.3 1.4e-41 141.8 0.3 4.6 3 1 0 3 3 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 KOH00740.1 - 5.2e-41 140.0 5.1 5.2e-41 140.0 5.1 4.6 4 0 0 4 4 2 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 KOH00740.1 - 5.4e-14 52.5 1.5 5.4e-14 52.5 1.5 6.9 6 2 0 6 6 3 1 CCR4-NOT transcription complex subunit 1 HEAT repeat TFIIA PF03153.13 KOH00740.1 - 8.3e-08 32.6 93.8 1.3e-05 25.4 42.5 2.3 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 KOH00740.1 - 1.2e-06 28.9 19.1 0.001 19.3 3.9 2.5 2 0 0 2 2 2 2 DDHD domain Neur_chan_memb PF02932.16 KOH00740.1 - 0.0003 20.9 23.0 0.019 15.0 5.0 2.4 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 KOH00740.1 - 0.00088 18.1 12.6 0.00088 18.1 12.6 2.3 2 0 0 2 2 2 1 Presenilin V_ATPase_I PF01496.19 KOH00740.1 - 0.0029 15.6 31.6 0.032 12.2 11.7 2.3 2 0 0 2 2 2 2 V-type ATPase 116kDa subunit family PNISR PF15996.5 KOH00740.1 - 0.0037 17.6 39.1 0.046 14.0 11.6 2.4 2 0 0 2 2 2 2 Arginine/serine-rich protein PNISR EPL1 PF10513.9 KOH00740.1 - 0.01 16.2 35.4 0.16 12.4 10.2 3.0 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF572 PF04502.13 KOH00740.1 - 0.011 15.4 31.3 0.32 10.6 12.9 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF572) FAM76 PF16046.5 KOH00740.1 - 0.014 14.7 35.1 0.067 12.5 9.1 2.4 2 0 0 2 2 2 0 FAM76 protein DUF5308 PF17233.2 KOH00740.1 - 0.032 14.5 25.1 0.054 13.7 4.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5308) Exonuc_VII_L PF02601.15 KOH00740.1 - 0.038 13.5 38.8 0.19 11.3 15.0 2.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit Pex14_N PF04695.13 KOH00740.1 - 0.099 13.3 67.5 0.054 14.1 20.1 2.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TERB2 PF15101.6 KOH00740.1 - 0.16 12.0 50.4 0.2 11.7 17.9 2.5 2 0 0 2 2 2 0 Telomere-associated protein TERB2 CNDH2_C PF16858.5 KOH00740.1 - 0.23 11.3 39.6 0.41 10.5 14.0 2.4 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SpoIIP PF07454.11 KOH00740.1 - 0.24 10.8 41.9 0.38 10.2 13.6 2.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) BSMAP PF12280.8 KOH00740.1 - 0.28 11.4 26.5 0.66 10.2 9.7 2.8 2 0 0 2 2 2 0 Brain specific membrane anchored protein SID-1_RNA_chan PF13965.6 KOH00740.1 - 0.31 9.4 14.9 1.1 7.6 2.7 2.3 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 BORG_CEP PF14957.6 KOH00740.1 - 0.38 11.9 29.7 2.7 9.2 13.0 2.7 2 0 0 2 2 2 0 Cdc42 effector Caldesmon PF02029.15 KOH00740.1 - 0.41 9.4 34.0 0.085 11.6 8.3 2.1 2 0 0 2 2 2 0 Caldesmon Tim54 PF11711.8 KOH00740.1 - 0.42 9.3 32.4 0.81 8.4 14.0 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 SET PF00856.28 KOH00740.1 - 0.57 10.5 6.1 8.8 6.7 0.9 2.9 2 0 0 2 2 2 0 SET domain SLC12 PF03522.15 KOH00740.1 - 0.66 8.9 41.5 0.8 8.7 16.5 2.4 2 0 0 2 2 2 0 Solute carrier family 12 PAT1 PF09770.9 KOH00740.1 - 0.92 7.7 81.1 0.083 11.2 25.8 2.4 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 MecA PF05389.12 KOH00740.1 - 1 9.0 26.5 3 7.4 8.2 2.8 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF4471 PF14740.6 KOH00740.1 - 1.9 7.6 25.8 4.4 6.4 7.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) DUF1387 PF07139.11 KOH00740.1 - 2 8.1 45.9 0.19 11.4 14.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) Gti1_Pac2 PF09729.9 KOH00740.1 - 2.1 8.4 34.1 0.25 11.4 9.0 2.7 3 0 0 3 3 2 0 Gti1/Pac2 family AF-4 PF05110.13 KOH00740.1 - 3.7 5.5 47.1 0.041 12.0 15.5 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein YjbH PF06082.11 KOH00740.1 - 4.3 6.0 30.2 0.55 9.0 4.5 2.3 2 0 0 2 2 2 0 Exopolysaccharide biosynthesis protein YbjH HNOBA PF07701.14 KOH00740.1 - 4.7 6.6 30.5 5.1 6.5 12.8 2.5 2 0 0 2 2 2 0 Heme NO binding associated Lin-8 PF03353.15 KOH00740.1 - 5.1 6.6 55.2 0.66 9.5 19.3 2.4 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist eIF-3_zeta PF05091.12 KOH00740.1 - 5.1 6.0 59.2 0.88 8.5 22.2 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EFTUD2 PF16004.5 KOH00740.1 - 5.2 7.7 36.0 0.41 11.2 9.7 2.7 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus RR_TM4-6 PF06459.12 KOH00740.1 - 5.5 6.7 45.7 1.7 8.4 15.9 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Draxin PF15550.6 KOH00740.1 - 6.3 6.6 27.1 0.79 9.5 6.4 2.3 2 0 0 2 2 2 0 Draxin Velvet PF11754.8 KOH00740.1 - 8.3 6.3 41.9 0.32 10.9 11.9 2.7 3 0 0 3 3 2 0 Velvet factor ASC PF00858.24 KOH00740.1 - 8.3 5.2 16.8 1.7 7.5 2.8 2.4 2 0 0 2 2 2 0 Amiloride-sensitive sodium channel GAGA_bind PF06217.12 KOH00740.1 - 9 6.5 35.2 2.3 8.4 13.1 2.5 2 0 0 2 2 2 0 GAGA binding protein-like family CDC50 PF03381.15 KOH00741.1 - 5.1e-93 311.6 1.3 6.2e-93 311.4 1.3 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Y_phosphatase2 PF03162.13 KOH00742.1 - 7.3e-45 152.5 2.4 2.8e-34 118.1 1.2 2.5 1 1 1 2 2 2 2 Tyrosine phosphatase family PAS_7 PF12860.7 KOH00742.1 - 0.068 13.3 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 PAS fold Homeodomain PF00046.29 KOH00743.1 - 7.8e-10 38.4 1.1 1.2e-09 37.9 1.1 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KOH00743.1 - 1.3e-07 31.4 0.5 2.7e-07 30.4 0.5 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 KOH00743.1 - 0.0096 15.4 0.1 0.18 11.3 0.0 2.1 1 1 1 2 2 2 1 Homeodomain leucine-zipper encoding, Homez Hyphal_reg_CWP PF11765.8 KOH00744.1 - 3.4e-25 88.7 9.4 7.1e-25 87.6 9.4 1.5 1 0 0 1 1 1 1 Hyphally regulated cell wall protein N-terminal Flocculin_t3 PF13928.6 KOH00744.1 - 0.0054 17.2 22.8 0.011 16.2 7.1 11.7 4 3 5 9 9 9 4 Flocculin type 3 repeat Bacteriocin_II PF01721.18 KOH00744.1 - 1.1 9.5 33.5 3.9 7.7 0.2 7.2 7 0 0 7 7 7 0 Class II bacteriocin Alpha-amylase PF00128.24 KOH00745.1 - 1.1e-124 416.4 0.3 1.5e-124 415.9 0.3 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 KOH00745.1 - 1e-06 28.7 0.0 2.8e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 KOH00745.1 - 0.0042 16.2 0.2 0.012 14.7 0.1 1.7 2 0 0 2 2 2 1 Glycogen debranching enzyme, glucanotransferase domain IL17R_fnIII_D2 PF16578.5 KOH00745.1 - 0.082 13.5 0.2 8.9 6.9 0.0 3.0 3 0 0 3 3 3 0 Interleukin 17 receptor D Sugar_tr PF00083.24 KOH00746.1 - 1.2e-97 327.6 22.5 1.4e-97 327.4 22.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOH00746.1 - 9.5e-10 37.9 23.4 9.5e-10 37.9 23.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KOH00746.1 - 3e-05 22.8 1.6 3e-05 22.8 1.6 2.3 2 0 0 2 2 2 1 MFS/sugar transport protein DUF5337 PF17272.2 KOH00746.1 - 6 6.8 6.8 7 6.6 0.2 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5337) SNO PF01174.19 KOH00747.1 - 1.6e-16 60.7 0.1 1.7e-16 60.6 0.1 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family Cid2 PF09774.9 KOH00748.1 - 1.3e-40 139.5 5.6 1.6e-40 139.1 5.6 1.1 1 0 0 1 1 1 1 Caffeine-induced death protein 2 Lgl_C PF08596.10 KOH00749.1 - 4.2e-146 486.6 0.4 3.9e-145 483.5 0.1 2.3 2 1 1 3 3 3 1 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 KOH00749.1 - 1.2e-09 38.4 1.1 0.00077 19.7 0.1 5.6 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOH00749.1 - 1.4e-06 28.9 0.1 1.7 9.7 0.0 4.1 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40_like PF17005.5 KOH00749.1 - 6.7e-05 22.4 2.9 0.00026 20.4 1.6 2.4 2 0 0 2 2 2 1 WD40-like domain BBS2_N PF14781.6 KOH00749.1 - 0.00066 19.6 0.0 0.018 14.9 0.0 3.1 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, N-terminal HPS3_N PF14761.6 KOH00749.1 - 0.026 14.0 1.1 2.6 7.5 0.3 3.0 1 1 1 3 3 3 0 Hermansky-Pudlak syndrome 3 Pkinase PF00069.25 KOH00750.1 - 9.9e-62 208.7 0.2 2.2e-60 204.2 0.0 2.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00750.1 - 1.1e-35 123.2 0.0 2.6e-35 122.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 KOH00750.1 - 2.4e-20 72.2 36.3 1.7e-11 43.8 15.1 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) HR1 PF02185.16 KOH00750.1 - 1.8e-16 60.0 16.4 3.7e-11 43.0 6.4 3.5 4 0 0 4 4 4 2 Hr1 repeat Pkinase_C PF00433.24 KOH00750.1 - 8e-13 48.9 5.2 1.7e-12 47.9 1.9 3.0 2 0 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.30 KOH00750.1 - 1e-06 29.0 0.1 2.4e-06 27.7 0.1 1.7 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 KOH00750.1 - 0.0001 21.7 0.0 0.00032 20.1 0.0 1.9 1 1 0 1 1 1 1 Kinase-like FliC PF12445.8 KOH00750.1 - 0.048 14.0 3.5 0.34 11.2 0.1 2.5 2 0 0 2 2 2 0 Flagellin protein Uds1 PF15456.6 KOH00750.1 - 0.06 13.5 0.3 0.06 13.5 0.3 3.9 3 1 0 3 3 3 0 Up-regulated During Septation zf-RING_9 PF13901.6 KOH00750.1 - 0.76 9.7 32.6 0.68 9.9 7.3 3.4 3 0 0 3 3 3 0 Putative zinc-RING and/or ribbon MutS_IV PF05190.18 KOH00750.1 - 0.85 10.0 6.0 4.5 7.7 0.4 2.7 2 0 0 2 2 2 0 MutS family domain IV zinc_ribbon_16 PF17034.5 KOH00751.1 - 4.3e-27 94.8 5.4 4.3e-27 94.8 5.4 2.6 3 0 0 3 3 3 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 KOH00751.1 - 2.6e-06 27.0 6.6 2.6e-06 27.0 6.6 1.8 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type Occludin_ELL PF07303.13 KOH00751.1 - 0.007 17.1 0.0 0.1 13.3 0.0 2.7 2 0 0 2 2 2 1 Occludin homology domain WD40 PF00400.32 KOH00751.1 - 0.016 16.1 0.5 4.1 8.4 0.0 4.2 4 0 0 4 4 4 0 WD domain, G-beta repeat HLH PF00010.26 KOH00752.1 - 1e-13 51.0 0.2 2.3e-13 49.8 0.2 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Got1 PF04178.12 KOH00753.1 - 2.6e-32 111.6 19.4 2.6e-32 111.6 19.4 1.4 2 0 0 2 2 2 1 Got1/Sft2-like family DUF2207 PF09972.9 KOH00753.1 - 5.9 5.5 10.2 1.8e+02 0.7 10.2 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Arrestin_C PF02752.22 KOH00754.1 - 2.4e-07 31.3 10.4 5.3e-06 26.9 5.1 4.1 4 1 0 4 4 4 1 Arrestin (or S-antigen), C-terminal domain ATP-synt_ab PF00006.25 KOH00755.1 - 7.6e-73 244.7 0.0 1.1e-72 244.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 KOH00755.1 - 1.4e-46 157.9 0.8 2.6e-46 157.0 0.8 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 KOH00755.1 - 4.3e-16 59.2 1.4 1.2e-15 57.8 1.4 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain FAD_binding_3 PF01494.19 KOH00756.1 - 6e-23 81.6 0.0 9.2e-23 81.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOH00756.1 - 8.4e-07 28.9 0.0 3.2e-05 23.7 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOH00756.1 - 1.2e-06 28.6 0.0 3.1e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 KOH00756.1 - 3.5e-06 26.4 0.0 5.5e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 KOH00756.1 - 7e-06 26.5 0.0 0.00016 22.1 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOH00756.1 - 0.00022 20.5 0.0 0.00046 19.5 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 KOH00756.1 - 0.00042 19.5 0.0 0.0046 16.0 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase ApbA PF02558.16 KOH00756.1 - 0.00048 19.8 0.0 0.00096 18.8 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 KOH00756.1 - 0.00052 19.9 0.0 0.001 19.0 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 KOH00756.1 - 0.0044 16.2 0.0 0.0073 15.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 KOH00756.1 - 0.0086 14.8 0.1 0.029 13.1 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.21 KOH00756.1 - 0.014 14.7 0.0 0.024 13.9 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 KOH00756.1 - 0.018 14.6 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 KOH00756.1 - 0.037 14.2 0.0 0.067 13.4 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox_3 PF13738.6 KOH00756.1 - 0.047 12.9 0.0 0.22 10.8 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KOH00756.1 - 0.12 11.2 0.0 6.8 5.4 0.0 2.3 2 0 0 2 2 2 0 Tryptophan halogenase Glu_dehyd_C PF16912.5 KOH00756.1 - 0.13 11.8 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 KOH00756.1 - 0.15 12.0 0.0 0.37 10.8 0.0 1.6 2 0 0 2 2 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Cnd2 PF05786.14 KOH00757.1 - 1.6e-139 466.9 44.2 1.8e-105 354.3 36.3 2.0 1 1 1 2 2 2 2 Condensin complex subunit 2 CNDH2_N PF06278.11 KOH00757.1 - 0.00079 19.6 0.0 0.00079 19.6 0.0 3.7 4 0 0 4 4 4 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal 4HBT PF03061.22 KOH00758.1 - 6.7e-06 26.4 0.0 1.2e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily Rox3 PF08633.10 KOH00759.1 - 5e-39 134.7 0.5 5.8e-39 134.5 0.5 1.1 1 0 0 1 1 1 1 Rox3 mediator complex subunit Ribosomal_L32e PF01655.18 KOH00760.1 - 2.2e-45 153.5 2.7 2.7e-45 153.2 2.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 DUF3437 PF11919.8 KOH00760.1 - 0.13 12.2 0.3 0.36 10.8 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) MFS_2 PF13347.6 KOH00761.1 - 0.027 13.0 0.1 0.032 12.8 0.1 1.0 1 0 0 1 1 1 0 MFS/sugar transport protein Peptidase_M24 PF00557.24 KOH00762.1 - 1e-51 175.6 0.0 1.3e-51 175.3 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF612 PF04747.12 KOH00762.1 - 0.0029 16.8 0.6 0.0037 16.5 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF612 Ribosomal_S21 PF01165.20 KOH00763.1 - 1.6e-10 40.6 1.3 1.6e-10 40.6 1.3 2.3 3 0 0 3 3 3 1 Ribosomal protein S21 Aa_trans PF01490.18 KOH00764.1 - 1.1e-122 409.8 19.6 1.2e-122 409.6 19.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KOH00764.1 - 5.1e-07 29.1 10.1 5.1e-07 29.1 10.1 2.1 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family DUF1129 PF06570.11 KOH00764.1 - 0.0052 16.3 6.0 0.91 9.0 0.2 3.8 4 1 0 4 4 4 3 Protein of unknown function (DUF1129) DUF3040 PF11239.8 KOH00764.1 - 0.84 10.0 6.2 19 5.6 0.0 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3040) PI3_PI4_kinase PF00454.27 KOH00765.1 - 3.5e-62 210.5 0.2 7.3e-61 206.1 0.0 2.7 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 KOH00765.1 - 1.1e-29 103.5 3.2 1.1e-29 103.5 3.2 3.4 3 0 0 3 3 3 1 Telomere-length maintenance and DNA damage repair FATC PF02260.20 KOH00765.1 - 9.3e-13 47.8 0.7 2.4e-12 46.5 0.0 2.1 2 0 0 2 2 2 1 FATC domain CENP-L PF13092.6 KOH00765.1 - 0.018 15.2 0.0 0.074 13.3 0.0 2.1 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 Ribosomal_L14 PF00238.19 KOH00766.1 - 1.5e-32 112.3 0.0 1.6e-32 112.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e NT-C2 PF10358.9 KOH00767.1 - 1.8e-50 170.4 1.8 3.3e-50 169.6 1.8 1.4 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins PH PF00169.29 KOH00768.1 - 4e-19 69.1 3.2 9e-19 67.9 0.0 3.0 3 0 0 3 3 3 1 PH domain SAM_2 PF07647.17 KOH00768.1 - 1.8e-13 50.3 0.2 4.1e-13 49.2 0.1 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.28 KOH00768.1 - 2.8e-12 46.0 0.1 5.9e-12 45.0 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOH00768.1 - 1.7e-08 34.2 0.1 3.3e-08 33.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_8 PF15409.6 KOH00768.1 - 1.1e-05 25.7 0.0 0.0005 20.3 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 KOH00768.1 - 0.0024 18.3 0.1 0.0024 18.3 0.1 3.6 2 2 0 2 2 2 1 Pleckstrin homology domain SH3_2 PF07653.17 KOH00768.1 - 0.009 15.7 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.30 KOH00768.1 - 0.068 13.6 0.1 0.13 12.7 0.1 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) TPR_2 PF07719.17 KOH00769.1 - 2.3e-37 124.1 9.7 9.2e-07 28.5 0.2 9.1 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 KOH00769.1 - 7.4e-33 110.0 12.1 3.3e-05 23.8 0.0 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 KOH00769.1 - 9.5e-33 110.7 12.0 6.9e-09 35.1 0.0 8.7 8 0 0 8 8 8 6 Tetratricopeptide repeat ANAPC3 PF12895.7 KOH00769.1 - 5.4e-23 81.0 27.1 1e-13 51.3 3.8 4.4 5 0 0 5 5 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 KOH00769.1 - 3.5e-22 77.8 16.7 6.4e-06 25.8 0.0 8.1 6 2 4 10 10 10 5 TPR repeat TPR_17 PF13431.6 KOH00769.1 - 7.9e-20 69.7 8.8 9.1e-06 25.7 0.4 8.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOH00769.1 - 3.5e-18 66.0 0.1 2.6e-07 31.2 0.0 4.0 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOH00769.1 - 1.3e-14 53.7 0.1 0.0036 18.0 0.0 6.4 4 2 3 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOH00769.1 - 2e-14 53.6 5.5 0.0017 18.6 0.0 7.2 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOH00769.1 - 1e-13 51.6 2.0 0.00034 21.1 0.0 4.3 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_6 PF13174.6 KOH00769.1 - 3.4e-11 43.0 10.3 0.05 14.3 0.0 7.4 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 KOH00769.1 - 3e-09 36.9 0.0 0.00076 19.6 0.0 4.5 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOH00769.1 - 1e-07 31.5 6.4 1.9 8.7 0.2 7.4 9 0 0 9 9 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOH00769.1 - 1.9e-05 24.0 0.0 0.0072 15.6 0.0 3.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_20 PF14561.6 KOH00769.1 - 0.00027 21.2 0.0 0.23 11.8 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOH00769.1 - 0.00032 20.5 1.9 4.5 7.3 0.1 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF3856 PF12968.7 KOH00769.1 - 0.0056 16.8 0.0 1.8 8.6 0.0 3.3 3 1 0 3 3 3 1 Domain of Unknown Function (DUF3856) BTAD PF03704.17 KOH00769.1 - 0.12 12.8 0.3 19 5.6 0.2 2.6 1 1 1 2 2 2 0 Bacterial transcriptional activator domain SRP_TPR_like PF17004.5 KOH00769.1 - 0.2 11.7 3.1 0.29 11.1 0.5 2.6 2 1 0 2 2 2 0 Putative TPR-like repeat Sel1 PF08238.12 KOH00769.1 - 0.21 12.3 4.2 17 6.2 0.1 4.6 5 0 0 5 5 3 0 Sel1 repeat ALG3 PF05208.13 KOH00770.1 - 7.1e-132 440.2 17.4 9.4e-132 439.8 17.4 1.1 1 0 0 1 1 1 1 ALG3 protein DUF5349 PF17298.2 KOH00771.1 - 1e-132 443.3 60.9 1.2e-132 443.1 60.9 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5349) GatB_N PF02934.15 KOH00772.1 - 8.7e-90 300.8 0.0 1.1e-89 300.5 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 KOH00772.1 - 3.4e-30 104.9 0.0 5.4e-30 104.2 0.0 1.3 1 0 0 1 1 1 1 GatB domain Nucleoporin_N PF08801.11 KOH00773.1 - 1.7e-136 455.4 9.3 3.2e-136 454.5 9.3 1.5 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 KOH00773.1 - 3.5e-121 405.9 9.1 1.5e-120 403.8 9.1 1.8 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Atg8 PF02991.16 KOH00774.1 - 9.4e-51 170.3 0.1 1.1e-50 170.2 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KOH00774.1 - 8.8e-07 29.3 0.0 1.1e-06 28.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 tRNA-synt_1 PF00133.22 KOH00775.1 - 1.5e-244 812.9 0.9 4.1e-244 811.4 0.2 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KOH00775.1 - 1.1e-25 90.3 0.0 4.4e-25 88.4 0.0 2.0 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KOH00775.1 - 4.6e-16 58.5 2.0 1.8e-05 23.7 0.3 3.9 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 KOH00775.1 - 0.0014 18.0 0.0 0.0043 16.4 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain AAR2 PF05282.11 KOH00776.1 - 2.1e-31 109.6 0.5 2.9e-31 109.2 0.5 1.1 1 0 0 1 1 1 1 AAR2 protein Agenet PF05641.12 KOH00776.1 - 0.17 12.4 1.6 0.43 11.1 0.2 2.4 1 1 1 2 2 2 0 Agenet domain Ribosomal_S8e PF01201.22 KOH00777.1 - 5.1e-57 191.9 2.5 6.7e-57 191.5 2.5 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e zf-CSL PF05207.13 KOH00778.1 - 2.2e-22 78.5 0.6 2.8e-22 78.2 0.6 1.2 1 0 0 1 1 1 1 CSL zinc finger ADH_zinc_N_2 PF13602.6 KOH00779.1 - 1.8e-14 55.0 0.0 3.1e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOH00779.1 - 2.9e-05 23.9 0.1 5.6e-05 23.0 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOH00779.1 - 0.034 14.1 0.0 0.088 12.8 0.0 1.7 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Pribosyltran_N PF13793.6 KOH00780.1 - 4.6e-42 142.6 0.1 2e-40 137.3 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 KOH00780.1 - 5e-34 117.9 0.5 5.1e-28 98.3 0.1 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 KOH00780.1 - 5.7e-17 61.7 0.9 2.9e-16 59.4 0.6 2.1 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KOH00780.1 - 0.00034 20.1 0.0 0.00058 19.4 0.0 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase UCH PF00443.29 KOH00781.1 - 1e-64 218.5 0.5 2.1e-64 217.5 0.1 1.7 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOH00781.1 - 1e-22 81.2 7.3 5.9e-19 68.8 2.5 2.6 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Fungal_trans PF04082.18 KOH00782.1 - 2.8e-24 85.6 3.1 6e-24 84.5 3.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOH00782.1 - 5.1e-11 42.5 10.4 8.1e-11 41.9 10.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AhpC-TSA PF00578.21 KOH00783.1 - 3e-31 107.9 0.1 4.3e-31 107.4 0.1 1.3 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 KOH00783.1 - 1.3e-14 53.8 0.1 2.1e-14 53.1 0.1 1.3 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 KOH00783.1 - 6.8e-11 42.1 0.1 9.8e-11 41.6 0.1 1.2 1 0 0 1 1 1 1 Redoxin Kinesin PF00225.23 KOH00784.1 - 4.3e-109 364.5 9.1 4.3e-109 364.5 9.1 2.2 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOH00784.1 - 2.8e-27 95.5 0.3 2.8e-27 95.5 0.3 4.6 3 1 2 5 5 5 1 Microtubule binding Apolipoprotein PF01442.18 KOH00784.1 - 1.9e-06 27.9 2.5 0.0074 16.2 0.0 2.8 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain Sel1 PF08238.12 KOH00785.1 - 6e-42 141.1 17.2 2.6e-06 27.9 0.7 7.5 7 0 0 7 7 7 7 Sel1 repeat Sec7 PF01369.20 KOH00786.1 - 7.1e-16 58.4 0.4 1.4e-15 57.4 0.4 1.5 1 0 0 1 1 1 1 Sec7 domain SEP PF08059.13 KOH00788.1 - 3e-22 79.0 0.6 9.8e-22 77.3 0.1 2.1 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 KOH00788.1 - 6.1e-19 68.0 0.0 1.2e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 KOH00788.1 - 1.6e-07 31.0 2.2 2.8e-07 30.2 2.2 1.4 1 0 0 1 1 1 1 UBA-like domain PTH2 PF01981.16 KOH00789.1 - 9.1e-44 148.5 0.1 1.2e-43 148.1 0.1 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 RXT2_N PF08595.11 KOH00789.1 - 0.015 15.3 0.1 0.022 14.8 0.1 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.10 KOH00789.1 - 0.036 14.5 3.0 0.056 13.8 3.0 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Treacle PF03546.14 KOH00789.1 - 0.063 12.1 0.6 0.091 11.6 0.6 1.2 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle FerI PF08151.12 KOH00789.1 - 0.16 12.1 2.8 0.29 11.3 2.8 1.5 1 0 0 1 1 1 0 FerI (NUC094) domain PP2C PF00481.21 KOH00790.1 - 5.1e-86 288.5 0.1 8.2e-86 287.8 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C DUF1796 PF08795.10 KOH00790.1 - 0.065 13.2 0.2 0.12 12.4 0.2 1.3 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Myb_DNA-binding PF00249.31 KOH00791.1 - 2.6e-11 43.5 1.5 2.3e-10 40.5 0.2 2.8 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOH00791.1 - 3.9e-09 36.6 3.8 4.2e-08 33.3 0.5 2.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Ribosomal_60s PF00428.19 KOH00791.1 - 0.00069 20.2 4.9 0.0014 19.1 4.9 1.5 1 0 0 1 1 1 1 60s Acidic ribosomal protein Campylo_MOMP PF05538.11 KOH00791.1 - 1.4 7.9 5.7 2.3 7.1 5.7 1.2 1 0 0 1 1 1 0 Campylobacter major outer membrane protein MOZ_SAS PF01853.18 KOH00792.1 - 2.8e-74 248.7 0.7 4.3e-74 248.1 0.7 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 KOH00792.1 - 6.7e-20 70.4 6.5 1.9e-19 69.0 6.5 1.8 1 0 0 1 1 1 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 KOH00792.1 - 0.012 16.0 0.0 0.029 14.8 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain BUD22 PF09073.10 KOH00792.1 - 2.7 7.3 18.6 5.2 6.3 18.6 1.6 1 0 0 1 1 1 0 BUD22 PPP4R2 PF09184.11 KOH00792.1 - 9 5.8 24.1 1.9 8.0 19.6 2.1 2 0 0 2 2 2 0 PPP4R2 RRM_1 PF00076.22 KOH00793.1 - 6e-07 29.2 0.0 2.3e-06 27.3 0.0 2.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_2 PF04059.12 KOH00793.1 - 0.02 15.1 0.1 0.051 13.8 0.1 1.6 1 0 0 1 1 1 0 RNA recognition motif 2 DUF3465 PF11948.8 KOH00793.1 - 0.021 14.7 0.6 0.066 13.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3465) SNAP PF14938.6 KOH00794.1 - 4.5e-104 347.8 8.6 5e-104 347.7 8.6 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 KOH00794.1 - 0.00036 21.0 0.3 36 5.3 0.0 5.1 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOH00794.1 - 0.00069 19.9 3.5 2.4 8.5 0.7 3.5 1 1 3 4 4 4 4 Tetratricopeptide repeat Foie-gras_1 PF11817.8 KOH00794.1 - 0.031 13.8 0.0 0.072 12.7 0.0 1.5 1 1 0 1 1 1 0 Foie gras liver health family 1 MIT PF04212.18 KOH00794.1 - 0.038 14.1 5.1 0.46 10.6 0.2 3.4 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF2225 PF09986.9 KOH00794.1 - 0.038 13.7 1.9 1.7 8.3 1.9 2.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) Endonuc-MspI PF09208.10 KOH00794.1 - 0.044 13.2 0.5 0.086 12.2 0.1 1.6 2 0 0 2 2 2 0 Restriction endonuclease MspI TPR_7 PF13176.6 KOH00794.1 - 0.15 12.2 2.0 2.3 8.4 0.1 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOH00794.1 - 0.24 11.6 6.4 12 6.3 0.1 5.0 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOH00794.1 - 0.63 10.0 7.3 1.3 9.0 0.1 4.3 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOH00794.1 - 0.93 9.9 7.7 18 5.9 0.2 4.8 4 2 1 5 5 5 0 Tetratricopeptide repeat Yippee-Mis18 PF03226.14 KOH00795.1 - 4.8e-16 58.9 4.0 6.2e-16 58.5 4.0 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 KOH00795.1 - 0.0099 16.1 0.7 0.013 15.7 0.7 1.2 1 0 0 1 1 1 1 C-terminal domain of RIG-I VWA_3_C PF18571.1 KOH00795.1 - 0.18 11.7 0.2 0.25 11.2 0.2 1.2 1 0 0 1 1 1 0 von Willebrand factor type A C-terminal domain EF-hand_4 PF12763.7 KOH00796.1 - 2.5e-33 114.1 2.2 7.6e-10 38.7 0.0 4.3 4 0 0 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 KOH00796.1 - 1.1e-09 37.1 1.0 0.0011 18.3 0.1 3.7 4 0 0 4 4 3 2 EF hand UBA PF00627.31 KOH00796.1 - 7.3e-09 35.4 0.0 1.8e-08 34.1 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_7 PF13499.6 KOH00796.1 - 3.2e-08 33.9 0.0 0.066 13.7 0.0 4.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOH00796.1 - 2.5e-06 27.0 0.1 0.38 10.8 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain DUF3584 PF12128.8 KOH00796.1 - 1.5e-05 22.8 51.3 2.8e-05 21.9 51.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) UBA_4 PF14555.6 KOH00796.1 - 9.2e-05 22.2 0.4 0.00026 20.7 0.4 1.8 1 0 0 1 1 1 1 UBA-like domain CENP-F_leu_zip PF10473.9 KOH00796.1 - 0.0034 17.4 30.3 0.0034 17.4 30.3 3.0 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 KOH00796.1 - 0.048 13.7 62.3 0.07 13.2 24.5 3.6 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein EF-hand_8 PF13833.6 KOH00796.1 - 0.11 12.4 0.5 11 5.9 0.1 3.2 3 0 0 3 3 3 0 EF-hand domain pair Atg14 PF10186.9 KOH00796.1 - 1.4 8.0 50.7 0.16 11.0 14.7 3.1 1 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TSC22 PF01166.18 KOH00796.1 - 1.7 9.0 14.1 12 6.3 0.9 4.5 3 0 0 3 3 3 0 TSC-22/dip/bun family Spc7 PF08317.11 KOH00796.1 - 7.6 5.3 60.0 6.8 5.5 32.1 3.2 1 1 0 2 2 2 0 Spc7 kinetochore protein PPP4R2 PF09184.11 KOH00797.1 - 1.1e-62 212.3 42.7 1.1e-62 212.3 42.7 3.2 1 1 1 2 2 2 1 PPP4R2 Peptidase_M16 PF00675.20 KOH00798.1 - 3.1e-30 105.1 1.2 5e-30 104.4 0.2 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KOH00798.1 - 7e-25 88.1 0.1 1.3e-24 87.2 0.1 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain PE PF00934.20 KOH00799.1 - 0.1 13.0 0.1 0.28 11.5 0.1 1.7 1 0 0 1 1 1 0 PE family DASH_Dad4 PF08650.10 KOH00799.1 - 0.14 12.1 0.1 0.34 10.9 0.1 1.6 1 0 0 1 1 1 0 DASH complex subunit Dad4 Transp_cyt_pur PF02133.15 KOH00800.1 - 1.2e-150 502.2 36.0 1.4e-150 502.0 36.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Transp_cyt_pur PF02133.15 KOH00801.1 - 4e-169 563.0 37.9 4.7e-169 562.8 37.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Proteasome PF00227.26 KOH00802.1 - 2.7e-35 121.6 0.1 2e-34 118.8 0.1 1.9 1 1 0 1 1 1 1 Proteasome subunit Gemini_AL3 PF01407.17 KOH00802.1 - 0.17 11.7 0.0 0.3 10.9 0.0 1.3 1 0 0 1 1 1 0 Geminivirus AL3 protein ER_lumen_recept PF00810.18 KOH00803.1 - 7.3e-39 133.9 11.7 1.1e-38 133.3 11.7 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor CTP_synth_N PF06418.14 KOH00805.1 - 4.7e-124 413.0 0.2 6.1e-124 412.6 0.2 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 KOH00805.1 - 5.2e-57 192.7 0.0 7.9e-57 192.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 KOH00805.1 - 0.02 14.7 0.1 0.3 10.8 0.0 2.7 1 1 1 2 2 2 0 Peptidase C26 Ribosomal_L16 PF00252.18 KOH00806.1 - 1.5e-35 122.1 0.2 2e-35 121.7 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Adaptin_N PF01602.20 KOH00807.1 - 8.3e-137 456.9 19.6 1e-136 456.6 19.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 KOH00807.1 - 2.7e-06 27.5 0.0 7.4e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 KOH00807.1 - 5.4e-05 23.5 0.2 0.00017 21.8 0.2 1.9 1 0 0 1 1 1 1 Adaptin C-terminal domain Ala_racemase_N PF01168.20 KOH00808.1 - 1e-21 77.6 0.0 1.2e-21 77.4 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Pol_alpha_B_N PF08418.10 KOH00809.1 - 1.3e-66 225.1 4.3 1.9e-66 224.6 4.3 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 KOH00809.1 - 2.6e-58 196.8 0.1 2.6e-58 196.8 0.1 1.6 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B CLASP_N PF12348.8 KOH00810.1 - 1.1e-73 247.6 11.7 1.4e-69 234.2 4.7 2.9 3 0 0 3 3 3 2 CLASP N terminal GTP_cyclohydro2 PF00925.20 KOH00811.1 - 1.9e-56 190.1 0.0 3.2e-56 189.4 0.0 1.3 1 1 0 1 1 1 1 GTP cyclohydrolase II KH_1 PF00013.29 KOH00812.1 - 3.6e-29 100.4 9.7 2.4e-10 40.1 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 KOH00812.1 - 2.4e-05 24.1 4.8 0.86 9.5 0.2 3.5 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 KOH00812.1 - 9.5e-05 22.2 0.1 2 8.3 0.0 3.6 3 0 0 3 3 3 2 KH domain KH_5 PF13184.6 KOH00812.1 - 0.036 14.2 5.2 2.5 8.2 0.1 3.4 3 0 0 3 3 3 0 NusA-like KH domain Msap1 PF17077.5 KOH00813.1 - 1.1e-35 123.4 24.9 1.8e-35 122.7 24.9 1.2 1 0 0 1 1 1 1 Mitotic spindle associated protein SHE1 Mito_carr PF00153.27 KOH00814.1 - 2.4e-69 229.3 6.1 1.9e-25 88.6 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PsbX PF06596.11 KOH00814.1 - 2.4 8.3 5.6 6.3 6.9 1.6 2.9 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) Rep_1 PF01446.17 KOH00815.1 - 0.00037 20.1 0.5 0.00055 19.5 0.5 1.2 1 0 0 1 1 1 1 Replication protein zinc_ribbon_15 PF17032.5 KOH00815.1 - 0.00037 21.2 1.2 0.0006 20.5 1.2 1.3 1 0 0 1 1 1 1 zinc-ribbon family Zn_Tnp_IS1595 PF12760.7 KOH00815.1 - 0.068 13.2 6.1 1.8 8.6 0.8 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-LITAF-like PF10601.9 KOH00815.1 - 0.087 13.1 5.7 0.072 13.4 3.3 2.1 2 1 0 2 2 2 0 LITAF-like zinc ribbon domain TF_Zn_Ribbon PF08271.12 KOH00815.1 - 1.9 8.0 5.1 12 5.5 1.2 2.7 2 1 1 3 3 3 0 TFIIB zinc-binding RecR PF02132.15 KOH00815.1 - 2.7 7.6 5.3 8.4 6.1 1.9 2.2 2 0 0 2 2 2 0 RecR protein DUF2423 PF10338.9 KOH00817.1 - 3.3e-18 65.6 4.9 3.3e-18 65.6 4.9 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) DUF4241 PF14025.6 KOH00817.1 - 0.022 15.1 0.0 0.027 14.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4241) MSC PF09402.10 KOH00817.1 - 0.13 11.7 3.4 0.14 11.6 3.4 1.0 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Ribosomal_L19e PF01280.20 KOH00818.1 - 9.4e-58 194.4 10.8 9.4e-58 194.4 10.8 1.5 2 0 0 2 2 2 1 Ribosomal protein L19e LSM PF01423.22 KOH00820.1 - 9.5e-19 66.9 0.3 1.3e-18 66.5 0.3 1.2 1 0 0 1 1 1 1 LSM domain UAF_Rrn10 PF05234.11 KOH00821.1 - 1e-61 206.5 0.3 1.2e-61 206.2 0.3 1.0 1 0 0 1 1 1 1 UAF complex subunit Rrn10 Methyltr_RsmB-F PF01189.17 KOH00822.1 - 1.2e-41 142.5 0.2 8.2e-41 139.9 0.2 2.2 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KOH00822.1 - 0.0026 17.9 0.0 0.0051 16.9 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase MCM PF00493.23 KOH00823.1 - 4e-102 340.0 0.0 6.7e-102 339.3 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KOH00823.1 - 3.6e-36 123.8 0.0 6.7e-36 122.9 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KOH00823.1 - 4e-26 91.3 0.4 1e-25 89.9 0.4 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM2_N PF12619.8 KOH00823.1 - 8.2e-24 84.6 32.3 8.2e-24 84.6 32.3 3.8 5 0 0 5 5 5 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 KOH00823.1 - 2.2e-12 47.5 0.1 8.5e-12 45.6 0.1 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 KOH00823.1 - 2.7e-09 36.7 0.0 2.7e-07 30.2 0.0 2.5 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOH00823.1 - 1.6e-07 31.4 0.0 4.1e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KOH00823.1 - 0.00024 21.0 0.0 0.0016 18.3 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KOH00823.1 - 0.002 17.9 0.1 0.012 15.3 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain SelR PF01641.18 KOH00823.1 - 0.019 15.1 0.1 0.89 9.6 0.1 2.6 2 0 0 2 2 2 0 SelR domain AAA PF00004.29 KOH00823.1 - 0.027 14.9 1.4 0.054 13.9 0.0 2.3 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOH00823.1 - 0.044 13.5 0.1 0.093 12.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain Lon_C PF05362.13 KOH00824.1 - 3.2e-65 219.5 0.0 8.1e-65 218.2 0.0 1.7 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 KOH00824.1 - 1.5e-36 126.3 2.9 1.5e-36 126.3 2.9 2.4 3 0 0 3 3 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 KOH00824.1 - 3.5e-22 79.3 0.0 9.6e-22 77.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 KOH00824.1 - 5.6e-08 33.1 0.0 3.4e-07 30.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KOH00824.1 - 5.3e-07 29.7 0.0 1.4e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 KOH00824.1 - 1.5e-05 24.9 0.0 4.9e-05 23.2 0.0 1.9 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_22 PF13401.6 KOH00824.1 - 0.00025 21.3 0.0 0.0044 17.3 0.0 2.7 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KOH00824.1 - 0.0018 18.7 0.0 0.083 13.3 0.0 2.8 2 0 0 2 2 2 1 RNA helicase AAA_16 PF13191.6 KOH00824.1 - 0.0022 18.4 0.6 0.014 15.8 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 KOH00824.1 - 0.0027 18.3 0.8 0.014 15.9 0.0 2.7 3 0 0 3 3 1 1 AAA domain AAA_PrkA PF08298.11 KOH00824.1 - 0.0028 16.6 0.0 0.0059 15.6 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain AAA_14 PF13173.6 KOH00824.1 - 0.0042 17.1 0.1 0.038 14.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 KOH00824.1 - 0.0066 16.2 0.2 0.044 13.5 0.0 2.5 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 KOH00824.1 - 0.0068 16.2 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein SKI PF01202.22 KOH00824.1 - 0.031 14.4 0.5 0.11 12.7 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase baeRF_family11 PF18855.1 KOH00824.1 - 0.034 14.5 0.1 0.18 12.1 0.1 2.3 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 11 RsgA_GTPase PF03193.16 KOH00824.1 - 0.035 14.0 0.0 0.2 11.6 0.0 2.3 1 0 0 1 1 1 0 RsgA GTPase NTPase_1 PF03266.15 KOH00824.1 - 0.059 13.3 0.7 1.1 9.1 0.1 2.9 2 1 1 3 3 3 0 NTPase TsaE PF02367.17 KOH00824.1 - 0.075 13.0 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 KOH00824.1 - 0.14 11.6 0.3 0.42 10.1 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region ClpB_D2-small PF10431.9 KOH00824.1 - 0.19 11.8 1.8 1.3 9.2 0.1 3.0 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein CBFD_NFYB_HMF PF00808.23 KOH00825.1 - 6.1e-25 87.3 0.0 9.2e-25 86.7 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOH00825.1 - 7.7e-05 23.1 0.0 0.00011 22.6 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Rft-1 PF04506.13 KOH00826.1 - 4e-218 725.3 33.6 4.5e-218 725.1 33.6 1.0 1 0 0 1 1 1 1 Rft protein MatE PF01554.18 KOH00826.1 - 0.00091 18.9 3.7 0.00091 18.9 3.7 2.6 2 0 0 2 2 2 1 MatE Sortilin-Vps10 PF15902.5 KOH00827.1 - 7.5e-158 526.0 5.2 2.9e-143 477.9 3.7 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KOH00827.1 - 2.7e-77 258.9 14.7 3.8e-40 138.0 2.5 2.5 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KOH00827.1 - 3.8e-09 35.2 28.3 0.081 13.0 0.3 7.8 7 0 0 7 7 7 6 BNR/Asp-box repeat CHB_HEX_C PF03174.13 KOH00827.1 - 0.0043 17.0 3.7 9 6.4 0.1 3.6 3 0 0 3 3 3 2 Chitobiase/beta-hexosaminidase C-terminal domain Sortilin-Vps10 PF15902.5 KOH00828.1 - 2.4e-24 85.9 2.2 3.1e-24 85.6 2.2 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KOH00828.1 - 9.4e-06 24.9 4.2 1.3 9.3 0.3 4.3 3 0 0 3 3 3 3 BNR/Asp-box repeat PSII_BNR PF14870.6 KOH00828.1 - 0.063 12.5 0.6 0.18 11.0 0.0 2.1 2 1 1 3 3 3 0 Photosynthesis system II assembly factor YCF48 BNR_2 PF13088.6 KOH00828.1 - 0.072 12.4 0.1 0.44 9.8 0.1 2.1 1 1 0 1 1 1 0 BNR repeat-like domain Pkinase PF00069.25 KOH00829.1 - 3.3e-67 226.6 0.0 4.1e-67 226.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00829.1 - 1.3e-30 106.6 0.0 1.9e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOH00829.1 - 0.0065 15.5 1.5 0.016 14.1 1.5 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOH00829.1 - 0.024 14.0 0.1 0.043 13.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOH00829.1 - 0.079 12.3 0.0 0.19 11.0 0.0 1.6 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 KOH00829.1 - 0.13 12.2 0.1 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family AcetylCoA_hydro PF02550.15 KOH00830.1 - 4.3e-79 265.1 0.0 1.3e-78 263.5 0.0 1.8 2 0 0 2 2 2 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 KOH00830.1 - 2.6e-40 137.9 0.0 3.9e-40 137.3 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain CitF PF04223.12 KOH00830.1 - 0.0042 16.0 0.0 0.0067 15.4 0.0 1.3 1 0 0 1 1 1 1 Citrate lyase, alpha subunit (CitF) CoA_trans PF01144.23 KOH00830.1 - 0.017 14.5 0.0 0.092 12.1 0.0 2.1 2 0 0 2 2 2 0 Coenzyme A transferase Rrn6 PF10214.9 KOH00831.1 - 5.7e-150 501.5 29.6 7.5e-150 501.1 29.6 1.2 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Formyl_trans_N PF00551.19 KOH00832.1 - 5.3e-41 140.3 0.0 6.7e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase Acyltransferase PF01553.21 KOH00833.1 - 4.1e-11 42.6 0.0 2e-10 40.4 0.0 2.1 1 1 0 1 1 1 1 Acyltransferase Colicin-DNase PF12639.7 KOH00833.1 - 0.016 16.0 3.0 0.016 16.0 0.8 2.2 2 0 0 2 2 2 0 DNase/tRNase domain of colicin-like bacteriocin DUF5102 PF17104.5 KOH00834.1 - 1.8e-05 25.0 2.4 0.053 13.6 0.0 3.1 2 1 1 3 3 3 2 Domain of unknown function (DUF5102) Haspin_kinase PF12330.8 KOH00835.1 - 3.2e-130 434.3 11.8 3.2e-130 434.3 11.8 2.7 3 0 0 3 3 3 1 Haspin like kinase domain WD40 PF00400.32 KOH00836.1 - 2.1e-31 107.5 11.8 1.6e-08 35.0 0.1 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00836.1 - 3.7e-14 52.8 0.0 0.0078 16.5 0.0 6.2 4 1 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOH00836.1 - 2.1e-08 33.9 0.3 0.31 11.0 0.0 5.2 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Hira PF07569.11 KOH00836.1 - 1.2e-07 31.7 0.1 1.8e-06 27.8 0.0 2.3 2 0 0 2 2 2 1 TUP1-like enhancer of split HIRA_B PF09453.10 KOH00836.1 - 1.9e-07 30.8 1.8 5.5e-07 29.3 1.8 1.9 1 0 0 1 1 1 1 HIRA B motif Ge1_WD40 PF16529.5 KOH00836.1 - 0.00026 20.1 0.0 1.9 7.4 0.0 3.6 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KOH00836.1 - 0.0027 17.6 0.0 2.5 7.9 0.0 3.8 5 0 0 5 5 5 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 KOH00836.1 - 0.0063 15.9 0.0 0.16 11.3 0.0 2.8 2 0 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal IKI3 PF04762.12 KOH00836.1 - 0.022 12.8 0.1 4.6 5.1 0.0 2.7 2 1 1 3 3 3 0 IKI3 family WD40_like PF17005.5 KOH00836.1 - 0.061 12.6 0.0 1.1 8.5 0.0 2.9 3 0 0 3 3 3 0 WD40-like domain SH3_1 PF00018.28 KOH00837.1 - 9e-41 137.3 3.6 7.6e-14 51.1 0.1 4.2 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 KOH00837.1 - 7.7e-33 112.1 6.2 2.8e-11 43.1 0.1 4.0 4 0 0 4 4 4 3 Variant SH3 domain SHD1 PF03983.12 KOH00837.1 - 1.5e-31 108.0 0.0 3.1e-31 107.0 0.0 1.6 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_2 PF07653.17 KOH00837.1 - 3.5e-28 97.1 0.0 4.8e-08 32.6 0.0 4.4 4 0 0 4 4 4 4 Variant SH3 domain SAM_4 PF18017.1 KOH00837.1 - 0.0013 18.6 0.0 0.0032 17.4 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF3104 PF11302.8 KOH00837.1 - 0.11 12.3 0.1 0.55 10.0 0.1 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) Rsc14 PF08586.10 KOH00838.1 - 1.3e-36 125.4 0.1 1.9e-36 124.8 0.1 1.3 1 0 0 1 1 1 1 RSC complex, Rsc14/Ldb7 subunit Fungal_trans PF04082.18 KOH00839.1 - 4.5e-40 137.4 4.9 4.5e-40 137.4 4.9 2.7 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOH00839.1 - 3.4e-09 36.7 14.2 3.4e-09 36.7 14.2 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DRIM PF07539.12 KOH00840.1 - 1.2e-162 542.5 9.2 1.2e-162 542.5 9.2 3.7 3 2 1 4 4 4 1 Down-regulated in metastasis RabGAP-TBC PF00566.18 KOH00840.1 - 0.0016 18.1 0.0 0.013 15.1 0.0 2.7 1 0 0 1 1 1 1 Rab-GTPase-TBC domain HEAT_2 PF13646.6 KOH00840.1 - 0.0078 16.6 0.3 19 5.7 0.0 5.4 6 0 0 6 6 6 1 HEAT repeats UNC45-central PF11701.8 KOH00840.1 - 0.65 9.9 4.5 1.7 8.6 0.0 4.0 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central HEAT PF02985.22 KOH00840.1 - 0.67 10.4 6.4 1.1e+02 3.4 0.0 6.7 7 0 0 7 7 7 0 HEAT repeat ParcG PF10274.9 KOH00840.1 - 0.9 9.6 7.7 22 5.1 0.1 5.4 5 1 0 5 5 5 0 Parkin co-regulated protein Histone_H2A_C PF16211.5 KOH00841.1 - 5.5e-21 74.0 1.3 8.9e-21 73.3 1.3 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KOH00841.1 - 1.2e-17 64.5 0.0 1.7e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOH00841.1 - 7.4e-06 26.2 0.0 1.2e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone LcrG PF07216.12 KOH00841.1 - 0.053 13.5 0.0 0.081 12.9 0.0 1.4 1 0 0 1 1 1 0 LcrG protein Histone PF00125.24 KOH00842.1 - 3.5e-19 69.5 3.4 4.9e-19 69.0 3.4 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOH00842.1 - 7.7e-06 26.1 0.1 1.6e-05 25.1 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KOH00842.1 - 0.0016 18.9 0.0 0.0027 18.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CENP-W PF15510.6 KOH00842.1 - 0.025 14.8 0.0 0.037 14.2 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein YscO-like PF16789.5 KOH00842.1 - 0.04 14.0 0.3 0.047 13.7 0.3 1.1 1 0 0 1 1 1 0 YscO-like protein Thiamine_BP PF01910.17 KOH00843.1 - 7.1e-29 99.6 0.1 7.9e-29 99.4 0.1 1.0 1 0 0 1 1 1 1 Thiamine-binding protein Trehalase PF01204.18 KOH00844.1 - 6.6e-189 629.0 0.0 8.3e-189 628.7 0.0 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 KOH00844.1 - 2.8e-16 58.9 0.5 4.9e-16 58.1 0.5 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Prenyltransf PF01255.19 KOH00845.1 - 1.4e-73 247.2 0.0 1.7e-73 246.8 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase polyprenyl_synt PF00348.17 KOH00846.1 - 3.6e-68 229.4 0.0 7.5e-66 221.8 0.0 2.9 1 1 0 1 1 1 1 Polyprenyl synthetase Mannosyl_trans2 PF04188.13 KOH00847.1 - 1.5e-146 489.2 38.7 2.7e-145 485.1 38.7 1.9 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) MscS_TM PF12794.7 KOH00847.1 - 0.026 13.4 2.6 0.064 12.1 0.0 2.6 3 1 0 3 3 3 0 Mechanosensitive ion channel inner membrane domain 1 RCR PF12273.8 KOH00848.1 - 1.2e-31 109.8 0.4 1.9e-31 109.2 0.4 1.4 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red SARAF PF06682.12 KOH00848.1 - 0.013 15.2 0.2 0.018 14.7 0.1 1.3 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4834 PF16118.5 KOH00848.1 - 0.17 12.9 0.0 0.34 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Ac110_PIF PF07280.11 KOH00848.1 - 1.1 9.0 5.1 2.9 7.7 3.0 2.3 2 0 0 2 2 2 0 Per os infectivity factor AC110 Aldedh PF00171.22 KOH00849.1 - 2.2e-156 521.0 0.0 2.5e-156 520.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF5314 PF17241.2 KOH00849.1 - 0.079 12.6 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5314) Sel1 PF08238.12 KOH00850.1 - 1.2e-06 28.9 2.7 4.2e-06 27.3 0.1 2.8 3 0 0 3 3 3 1 Sel1 repeat CENP-T_C PF15511.6 KOH00851.1 - 2.7e-09 37.1 0.1 3.2e-09 36.9 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 KOH00851.1 - 5.5e-05 23.2 0.1 7.8e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 KOH00851.1 - 0.00014 22.3 0.1 0.00016 22.1 0.1 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOH00851.1 - 0.00021 21.5 0.1 0.00036 20.7 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 KOH00851.1 - 0.00029 21.2 0.1 0.00039 20.7 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 KOH00851.1 - 0.0089 16.1 0.0 0.011 15.8 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KOH00851.1 - 0.04 13.9 0.0 0.057 13.4 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.13 KOH00851.1 - 0.073 13.6 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 KOH00852.1 - 3.1e-49 166.7 3.4 3.4e-49 166.5 3.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 KOH00852.1 - 2e-06 28.1 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 KOH00852.1 - 5.5e-05 23.8 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 KOH00852.1 - 0.00011 22.3 0.8 0.00015 21.9 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 KOH00852.1 - 0.0018 18.5 0.9 0.0023 18.2 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KOH00852.1 - 0.035 14.2 0.2 0.058 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Pyrophosphatase PF00719.19 KOH00853.1 - 9.7e-59 197.8 0.2 1.3e-58 197.4 0.2 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Glutaredoxin PF00462.24 KOH00854.1 - 7e-15 55.0 0.0 1.6e-14 53.8 0.0 1.6 2 0 0 2 2 2 1 Glutaredoxin DUF3848 PF12959.7 KOH00854.1 - 0.031 14.3 1.1 0.031 14.3 1.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3848) Thioredoxin_2 PF13098.6 KOH00854.1 - 0.041 14.3 0.6 0.089 13.2 0.1 1.8 1 1 1 2 2 2 0 Thioredoxin-like domain Thioredoxin_9 PF14595.6 KOH00854.1 - 0.13 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin GEN1_C PF18380.1 KOH00854.1 - 0.14 13.1 0.4 0.14 13.1 0.4 1.7 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain Ac76 PF05814.11 KOH00854.1 - 0.24 11.4 0.1 0.24 11.4 0.1 1.9 2 0 0 2 2 2 0 Orf76 (Ac76) Mannosyl_trans3 PF11051.8 KOH00855.1 - 2.9e-82 276.1 0.0 5.5e-82 275.2 0.0 1.5 1 0 0 1 1 1 1 Mannosyltransferase putative CYSTM PF12734.7 KOH00856.1 - 2.2e-08 34.3 72.2 4.3e-06 26.9 40.7 5.1 1 1 1 2 2 2 1 Cysteine-rich TM module stress tolerance HEAT PF02985.22 KOH00857.1 - 1.3e-24 84.1 5.4 0.00028 20.9 0.0 9.5 9 0 0 9 9 9 4 HEAT repeat HEAT_EZ PF13513.6 KOH00857.1 - 4.2e-22 78.2 0.5 9.2e-13 48.4 0.0 8.1 7 1 1 8 8 8 1 HEAT-like repeat HEAT_2 PF13646.6 KOH00857.1 - 1.1e-13 51.3 0.0 0.00014 22.2 0.0 6.0 4 3 1 5 5 5 4 HEAT repeats Cnd1 PF12717.7 KOH00857.1 - 6.7e-08 32.7 10.5 0.099 12.7 0.0 5.5 6 1 1 7 7 7 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KOH00857.1 - 6e-05 23.6 0.1 3.3 8.4 0.0 5.0 5 1 0 5 5 5 1 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 KOH00857.1 - 0.0035 17.2 3.2 0.045 13.7 0.5 3.7 3 1 0 3 3 3 1 Importin-beta N-terminal domain UNC45-central PF11701.8 KOH00857.1 - 0.066 13.2 1.6 0.2 11.6 0.3 2.3 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central Pneumo_phosprot PF02478.16 KOH00857.1 - 0.083 12.4 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Pneumovirus phosphoprotein STAT1_TAZ2bind PF12162.8 KOH00857.1 - 0.11 12.1 0.1 1.2 8.8 0.0 2.4 2 0 0 2 2 2 0 STAT1 TAZ2 binding domain Arm PF00514.23 KOH00857.1 - 0.17 11.9 3.4 6.6 6.9 0.0 4.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat GalP_UDP_transf PF01087.22 KOH00858.1 - 2.2e-68 230.3 0.4 3.6e-68 229.6 0.4 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 KOH00858.1 - 4e-68 228.4 1.4 5.1e-68 228.0 0.4 1.6 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.23 KOH00858.1 - 0.0021 18.8 0.1 0.027 15.2 0.0 2.3 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 KOH00858.1 - 0.093 13.2 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding DUF4921 PF16268.5 KOH00858.1 - 0.097 11.5 0.9 4.8 5.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4921) Aldose_epim PF01263.20 KOH00859.1 - 1.1e-82 277.8 0.2 1.4e-82 277.3 0.2 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase GDP_Man_Dehyd PF16363.5 KOH00859.1 - 1.9e-58 198.5 0.0 3.2e-58 197.7 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOH00859.1 - 2e-54 184.6 0.0 6.6e-54 182.9 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KOH00859.1 - 2.2e-18 66.4 0.0 1.5e-16 60.4 0.0 2.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 KOH00859.1 - 5.8e-16 58.3 0.0 2.4e-15 56.3 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 KOH00859.1 - 1.6e-10 40.6 0.0 2.5e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 KOH00859.1 - 5.2e-08 33.0 0.0 8.2e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 KOH00859.1 - 2.6e-07 30.3 0.0 4.3e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 KOH00859.1 - 9.1e-07 28.3 0.0 1.5e-05 24.4 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 KOH00859.1 - 0.00019 21.4 0.0 0.00033 20.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GalKase_gal_bdg PF10509.9 KOH00860.1 - 1.4e-21 75.7 0.0 3e-21 74.7 0.0 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 KOH00860.1 - 2.3e-16 59.8 0.6 1e-15 57.7 0.4 2.2 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KOH00860.1 - 5.1e-11 42.8 0.0 1.2e-10 41.6 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal DUF1748 PF08520.10 KOH00860.1 - 0.056 13.4 0.0 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1748) Peptidase_M16_C PF05193.21 KOH00860.1 - 0.075 13.0 0.0 0.24 11.4 0.0 1.7 2 0 0 2 2 2 0 Peptidase M16 inactive domain Transp_cyt_pur PF02133.15 KOH00861.1 - 7.1e-182 605.1 36.3 8.3e-182 604.9 36.3 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Macro PF01661.21 KOH00862.1 - 1.8e-29 102.2 0.0 2.2e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 Macro domain Chitin_synth_2 PF03142.15 KOH00863.1 - 2.2e-290 963.7 0.1 2.2e-290 963.7 0.1 1.4 2 0 0 2 2 2 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 KOH00863.1 - 1.8e-11 44.3 0.0 6.3e-09 36.1 0.0 2.4 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 KOH00863.1 - 7.2e-11 42.4 1.2 2.4e-10 40.7 1.2 1.9 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 KOH00863.1 - 0.004 16.6 0.1 0.013 15.0 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 KOH00863.1 - 0.046 13.5 0.0 0.8 9.5 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family 2 Reticulon PF02453.17 KOH00863.1 - 0.049 13.6 7.5 0.26 11.3 0.9 3.2 3 0 0 3 3 3 0 Reticulon DUF3139 PF11337.8 KOH00863.1 - 0.1 13.3 1.7 0.95 10.2 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) SCO1-SenC PF02630.14 KOH00864.1 - 1e-46 158.2 0.0 1.5e-46 157.7 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 KOH00864.1 - 4e-06 26.8 0.0 9.7e-06 25.5 0.0 1.6 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_8 PF13905.6 KOH00864.1 - 0.0026 18.0 0.0 0.0087 16.4 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like YchF-GTPase_C PF06071.13 KOH00865.1 - 5.8e-36 122.5 0.0 1.6e-35 121.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 KOH00865.1 - 3.1e-17 62.7 0.0 1.2e-16 60.8 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 KOH00865.1 - 0.00085 19.3 0.0 0.002 18.2 0.0 1.6 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 KOH00865.1 - 0.0026 17.3 0.0 0.0052 16.3 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_23 PF13476.6 KOH00865.1 - 0.041 14.4 2.6 0.23 12.0 2.7 2.1 1 1 0 1 1 1 0 AAA domain Cupin_2 PF07883.11 KOH00865.1 - 0.16 11.7 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 Cupin domain ADH_zinc_N PF00107.26 KOH00866.1 - 1.7e-09 37.7 0.0 2.9e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FIBP PF05427.11 KOH00866.1 - 0.079 12.2 0.0 0.21 10.8 0.0 1.6 1 1 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) Pkinase PF00069.25 KOH00867.1 - 2.4e-63 214.0 0.2 1.1e-61 208.5 0.2 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00867.1 - 2e-34 119.1 0.0 1.8e-33 116.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 KOH00867.1 - 3e-06 27.8 1.3 1e-05 26.1 1.3 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 KOH00867.1 - 0.00089 18.7 0.0 0.0099 15.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOH00867.1 - 0.033 13.0 0.0 0.055 12.2 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase CTP_transf_1 PF01148.20 KOH00868.1 - 1.7e-81 273.9 18.5 2.1e-81 273.6 18.5 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family SET PF00856.28 KOH00869.1 - 1.4e-08 35.3 3.3 0.00026 21.4 0.0 3.4 3 0 0 3 3 3 2 SET domain Nop14 PF04147.12 KOH00869.1 - 0.00025 19.4 10.9 0.00025 19.4 10.9 1.6 2 0 0 2 2 2 1 Nop14-like family DUF4746 PF15928.5 KOH00869.1 - 0.093 12.1 5.4 0.16 11.4 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RPN2_C PF18004.1 KOH00869.1 - 0.9 9.4 5.1 1.9 8.4 5.1 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain ORC_WH_C PF18137.1 KOH00869.1 - 1.6 8.8 8.9 2.9 8.0 7.7 2.0 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Prothymosin PF03247.14 KOH00869.1 - 2.2 8.8 31.3 3.1 8.3 23.2 2.6 2 0 0 2 2 2 0 Prothymosin/parathymosin family Paf1 PF03985.13 KOH00869.1 - 9.4 5.1 19.1 45 2.9 18.1 2.1 2 0 0 2 2 2 0 Paf1 Ribosomal_L4 PF00573.22 KOH00870.1 - 1.6e-43 148.7 0.9 3e-43 147.8 0.9 1.5 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 KOH00870.1 - 1.1e-29 102.3 0.3 1.3e-28 98.8 0.2 2.3 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Sld5 PF05916.11 KOH00871.1 - 4.1e-09 36.9 1.7 6.9e-09 36.1 1.7 1.4 1 0 0 1 1 1 1 GINS complex protein PIF1 PF05970.14 KOH00871.1 - 0.002 17.3 0.3 0.011 15.0 0.0 1.8 1 1 1 2 2 2 1 PIF1-like helicase Occludin_ELL PF07303.13 KOH00871.1 - 0.015 16.1 2.6 0.015 16.1 2.6 2.2 2 1 0 2 2 2 0 Occludin homology domain Peptidase_M24_C PF16188.5 KOH00871.1 - 0.27 11.3 1.4 31 4.7 0.1 2.9 3 0 0 3 3 3 0 C-terminal region of peptidase_M24 SKA2 PF16740.5 KOH00871.1 - 0.35 10.7 5.1 1.1 9.1 0.1 2.2 1 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Wap1 PF16997.5 KOH00872.1 - 1.2e-105 353.8 26.8 1.2e-105 353.8 26.8 1.6 2 0 0 2 2 2 1 Wap1 domain Imm70 PF15601.6 KOH00872.1 - 0.036 13.6 0.5 0.13 11.8 0.1 2.2 2 0 0 2 2 2 0 Immunity protein 70 CRCB PF02537.15 KOH00873.1 - 5.7e-25 87.5 20.3 4.7e-16 58.9 5.7 2.4 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) Phage_holin_3_1 PF05106.12 KOH00873.1 - 4.7 7.7 6.0 6.1 7.3 0.3 3.1 2 1 0 2 2 2 0 Phage holin family (Lysis protein S) Phage_holin_3_3 PF16083.5 KOH00873.1 - 5.1 7.3 10.1 0.79 9.9 0.1 3.5 2 2 3 5 5 5 0 LydA holin phage, holin superfamily III PBP_sp32 PF07222.12 KOH00874.1 - 0.19 11.2 5.9 0.21 11.0 3.7 1.8 1 1 1 2 2 2 0 Proacrosin binding protein sp32 Mif2_N PF15624.6 KOH00874.1 - 9.7 6.9 13.4 1.4 9.6 8.0 2.0 1 1 1 2 2 2 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal DASH_Dad1 PF08649.10 KOH00875.1 - 7.5e-24 83.7 0.9 1e-23 83.3 0.9 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad1 GCR1_C PF12550.8 KOH00875.1 - 0.11 12.8 0.2 2.6 8.4 0.0 2.3 1 1 1 2 2 2 0 Transcriptional activator of glycolytic enzymes IPK PF03770.16 KOH00876.1 - 1.1e-49 169.0 0.7 3.9e-49 167.2 0.0 2.2 2 0 0 2 2 2 1 Inositol polyphosphate kinase Ribosomal_60s PF00428.19 KOH00876.1 - 0.066 13.8 1.1 0.15 12.7 1.1 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Bacteriocin_IIi PF11758.8 KOH00876.1 - 0.097 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Aureocin-like type II bacteriocin Acyltransferase PF01553.21 KOH00877.1 - 5.6e-31 107.0 0.0 7.9e-31 106.5 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 KOH00877.1 - 6.8e-12 45.3 0.1 1.7e-11 44.0 0.1 1.7 1 0 0 1 1 1 1 Acyltransferase C-terminus GCV_T PF01571.21 KOH00878.1 - 1e-84 284.0 0.0 1.2e-84 283.7 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 KOH00878.1 - 9.7e-12 44.6 0.0 2.1e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain PRK PF00485.18 KOH00879.1 - 1.2e-10 41.5 1.9 1.2e-10 41.5 1.9 1.5 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family DEAD PF00270.29 KOH00880.1 - 2.6e-44 151.1 2.7 4.7e-44 150.2 2.7 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOH00880.1 - 2.7e-33 114.6 1.4 2.3e-31 108.4 0.1 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOH00880.1 - 6.1e-06 26.3 0.1 1.3e-05 25.3 0.1 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 KOH00880.1 - 1.3e-05 25.0 0.4 2.5e-05 24.1 0.1 1.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOH00880.1 - 8.2e-05 23.0 0.3 0.00068 20.0 0.3 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOH00880.1 - 0.00046 20.5 0.8 0.0013 19.0 0.8 1.8 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 KOH00880.1 - 0.0009 18.8 3.9 0.0027 17.2 3.9 1.8 1 1 0 1 1 1 1 PhoH-like protein CMS1 PF14617.6 KOH00880.1 - 0.0014 18.0 0.7 0.007 15.7 0.0 2.3 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 KOH00880.1 - 0.0032 17.3 0.0 0.0074 16.2 0.0 1.6 1 1 0 1 1 1 1 Helicase AAA PF00004.29 KOH00880.1 - 0.027 14.9 1.3 0.14 12.6 1.3 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CobA_CobO_BtuR PF02572.15 KOH00880.1 - 0.049 13.9 0.1 0.1 12.9 0.1 1.5 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP TniB PF05621.11 KOH00880.1 - 0.053 12.9 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Flavi_DEAD PF07652.14 KOH00880.1 - 0.066 13.2 0.0 0.43 10.5 0.0 2.2 1 1 0 1 1 1 0 Flavivirus DEAD domain Atg31 PF09795.9 KOH00881.1 - 8.6e-53 178.5 5.8 1e-52 178.3 5.8 1.1 1 0 0 1 1 1 1 Autophagy-related protein 31 tRNA-synt_2b PF00587.25 KOH00882.1 - 2.3e-32 112.4 0.1 4.4e-32 111.5 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 KOH00882.1 - 2.9e-23 82.1 9.5 2.9e-23 82.1 9.5 1.9 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 KOH00882.1 - 0.088 11.4 6.7 0.14 10.7 6.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A PCRF PF03462.18 KOH00882.1 - 0.64 9.8 5.5 1.4 8.7 4.8 1.8 2 0 0 2 2 2 0 PCRF domain RRM_3 PF08777.11 KOH00882.1 - 5.1 7.2 10.5 3 7.9 6.7 2.5 3 0 0 3 3 3 0 RNA binding motif Ribosomal_S17_N PF16205.5 KOH00883.1 - 7.4e-32 109.5 0.8 1.4e-31 108.7 0.8 1.5 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 KOH00883.1 - 2.3e-27 94.9 4.7 2.3e-27 94.9 4.7 1.7 2 0 0 2 2 2 1 Ribosomal protein S17 DUF922 PF06037.11 KOH00883.1 - 0.04 13.7 0.0 0.065 13.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) Myb_DNA-binding PF00249.31 KOH00884.1 - 1.5e-21 76.3 17.2 6.4e-12 45.5 0.7 4.6 3 2 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOH00884.1 - 1e-16 60.9 11.8 1.9e-13 50.5 1.3 4.1 3 1 0 3 3 3 2 Myb-like DNA-binding domain DUF1376 PF07120.11 KOH00884.1 - 0.019 15.3 0.2 0.12 12.7 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1376) SANT_DAMP1_like PF16282.5 KOH00884.1 - 0.12 12.6 2.7 1.4 9.2 0.1 3.2 3 0 0 3 3 3 0 SANT/Myb-like domain of DAMP1 Vps54 PF07928.12 KOH00885.1 - 0.00018 22.0 0.1 0.0012 19.3 0.1 2.5 1 0 0 1 1 1 1 Vps54-like protein DUF2333 PF10095.9 KOH00885.1 - 0.077 12.0 0.8 0.13 11.2 0.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) DUF1759 PF03564.15 KOH00885.1 - 0.11 12.5 0.1 0.11 12.5 0.1 3.7 5 0 0 5 5 5 0 Protein of unknown function (DUF1759) DUF5617 PF18493.1 KOH00885.1 - 0.35 11.0 5.3 0.8 9.8 0.6 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5617) DUF1752 PF08550.10 KOH00886.1 - 2.3e-13 49.7 2.8 6e-13 48.4 2.8 1.8 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) WD40 PF00400.32 KOH00887.1 - 6.3e-12 45.8 12.5 0.014 16.2 0.2 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH00887.1 - 2.6e-06 27.6 0.9 3.1 8.2 0.0 5.7 6 0 0 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain CX9C PF16860.5 KOH00888.1 - 4.1e-25 87.5 5.8 1e-16 60.7 0.4 2.1 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 KOH00888.1 - 7.2e-11 41.9 7.7 6.6e-07 29.3 0.5 2.7 2 1 0 2 2 2 2 CHCH domain UPF0203 PF05254.12 KOH00888.1 - 7.3e-06 26.1 6.6 0.0011 19.1 0.8 3.1 1 1 2 3 3 3 3 Uncharacterised protein family (UPF0203) GCK PF07802.11 KOH00888.1 - 1.9e-05 25.0 4.0 0.048 14.1 0.1 2.4 1 1 0 2 2 2 2 GCK domain NDUF_B7 PF05676.13 KOH00888.1 - 0.0011 18.7 6.2 0.031 14.0 0.3 2.9 1 1 2 3 3 3 2 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 KOH00888.1 - 0.002 18.1 6.4 0.035 14.1 1.3 2.5 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like YbfN PF13982.6 KOH00888.1 - 0.0028 17.9 2.0 0.96 9.8 0.1 2.2 1 1 1 2 2 2 2 YbfN-like lipoprotein Pet191_N PF10203.9 KOH00888.1 - 0.0042 17.4 9.2 0.033 14.5 1.7 2.7 1 1 2 3 3 3 3 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.17 KOH00888.1 - 0.008 16.4 5.1 0.044 14.0 0.3 2.1 1 1 1 2 2 2 1 Cytochrome oxidase c subunit VIb UCR_hinge PF02320.16 KOH00888.1 - 0.019 15.2 5.7 0.055 13.7 1.4 2.6 1 1 2 3 3 3 0 Ubiquinol-cytochrome C reductase hinge protein DB PF01682.19 KOH00888.1 - 0.02 15.1 3.2 0.02 15.1 3.2 1.9 1 1 1 2 2 2 0 DB module MTCP1 PF08991.10 KOH00888.1 - 0.93 9.8 6.9 6.4 7.1 1.4 2.4 1 1 1 2 2 2 0 Mature-T-Cell Proliferation I type COX17 PF05051.13 KOH00888.1 - 2.7 8.4 9.1 6.8 7.1 1.6 2.9 1 1 1 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) FMN_red PF03358.15 KOH00889.1 - 1.8e-10 40.7 0.0 2.7e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 KOH00889.1 - 6.3e-05 22.8 0.0 8.1e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 KOH00889.1 - 0.16 12.1 0.9 0.94 9.7 0.8 2.3 1 1 1 2 2 2 0 Flavodoxin Bac_rhodopsin PF01036.18 KOH00890.1 - 1.5e-38 132.6 13.8 1.8e-38 132.3 13.8 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein Phage_holin_1 PF04531.13 KOH00890.1 - 0.014 15.9 0.2 0.041 14.4 0.2 1.7 1 0 0 1 1 1 0 Bacteriophage holin Fungal_trans_2 PF11951.8 KOH00891.1 - 2.6e-23 82.5 2.0 4.3e-23 81.7 2.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOH00891.1 - 8.2e-07 29.1 12.7 1.7e-06 28.1 12.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SelP_N PF04592.14 KOH00891.1 - 3 7.2 11.1 5.9 6.2 11.1 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DAHP_synth_1 PF00793.20 KOH00892.1 - 1.6e-107 358.4 0.0 1.9e-107 358.2 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family ECH_2 PF16113.5 KOH00893.1 - 2.5e-91 306.6 0.0 3.3e-91 306.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 KOH00893.1 - 2.1e-28 99.3 0.0 4.2e-28 98.3 0.0 1.5 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Cytochrome-c551 PF10643.9 KOH00893.1 - 0.088 12.4 0.2 0.21 11.2 0.1 1.7 2 0 0 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 tRNA-synt_2 PF00152.20 KOH00894.1 - 7.7e-76 255.2 0.1 1.1e-75 254.6 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOH00894.1 - 2.1e-12 46.9 0.2 5.1e-12 45.6 0.2 1.7 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KOH00894.1 - 4.8e-07 29.5 0.0 0.0039 16.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) E1-E2_ATPase PF00122.20 KOH00895.1 - 1.9e-36 125.3 17.6 1.1e-30 106.5 0.2 4.7 5 0 0 5 5 5 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 KOH00895.1 - 4.3e-29 101.5 0.6 4.3e-29 101.5 0.6 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 KOH00895.1 - 5.5e-20 72.6 0.0 2.6e-16 60.6 0.0 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOH00895.1 - 2.3e-19 69.3 0.0 4.6e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KOH00895.1 - 3.2e-15 55.6 0.0 6e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOH00895.1 - 0.00078 19.3 0.8 0.0032 17.2 0.6 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2157 PF09925.9 KOH00895.1 - 0.11 12.3 1.5 0.43 10.4 1.5 2.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) MerC PF03203.14 KOH00895.1 - 7.6 7.0 10.9 1.1 9.7 2.5 2.8 2 0 0 2 2 2 0 MerC mercury resistance protein Ribosomal_S10 PF00338.22 KOH00896.1 - 2.2e-31 108.0 0.0 3.4e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e zf-H2C2_2 PF13465.6 KOH00898.1 - 0.00053 20.3 5.3 0.00053 20.3 5.3 3.4 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.26 KOH00898.1 - 0.00063 20.1 0.7 0.00063 20.1 0.7 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOH00898.1 - 0.0021 18.7 14.6 0.047 14.6 0.4 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 KOH00898.1 - 0.029 15.0 1.7 0.079 13.6 0.2 2.3 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats Coprogen_oxidas PF01218.18 KOH00899.1 - 4.3e-134 445.9 0.0 4.9e-134 445.7 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase TFIIS_C PF01096.18 KOH00900.1 - 8.9e-22 76.7 2.1 8.9e-22 76.7 2.1 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 KOH00900.1 - 6.7e-18 64.3 1.6 5.5e-17 61.3 0.2 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit IBR PF01485.21 KOH00900.1 - 0.13 12.5 8.0 1.3 9.3 0.1 2.8 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Baculo_LEF5_C PF11792.8 KOH00900.1 - 0.38 10.5 0.1 0.38 10.5 0.1 2.1 3 0 0 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain zf-ribbon_3 PF13248.6 KOH00900.1 - 0.58 9.6 0.1 0.58 9.6 0.1 3.8 4 1 0 4 4 4 0 zinc-ribbon domain AA_permease PF00324.21 KOH00901.1 - 1.1e-134 449.7 35.4 1.3e-134 449.4 35.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOH00901.1 - 1.1e-33 116.8 32.9 1.4e-33 116.4 32.9 1.1 1 0 0 1 1 1 1 Amino acid permease URO-D PF01208.17 KOH00902.1 - 4.3e-129 430.6 0.0 4.8e-129 430.4 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) bVLRF1 PF18826.1 KOH00903.1 - 1.9e-57 193.3 0.5 4.6e-57 192.1 0.0 1.9 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 KOH00903.1 - 3e-05 24.2 0.0 0.00032 20.9 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) bPH_1 PF08000.11 KOH00903.1 - 0.033 14.3 0.0 0.083 13.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial PH domain E6 PF00518.17 KOH00903.1 - 0.068 13.6 1.8 0.18 12.3 0.2 2.4 2 0 0 2 2 2 0 Early Protein (E6) Ank_2 PF12796.7 KOH00903.1 - 0.12 13.0 0.0 0.24 12.0 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) zf-C2H2_jaz PF12171.8 KOH00903.1 - 0.14 12.5 1.7 0.26 11.6 0.2 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOH00903.1 - 7.2 7.1 5.9 2.7 8.5 0.4 2.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type TIM PF00121.18 KOH00904.1 - 3e-88 295.3 0.0 3.4e-88 295.1 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase His_Phos_1 PF00300.22 KOH00905.1 - 7.2e-26 91.1 0.0 2.4e-14 53.5 0.0 3.1 3 0 0 3 3 3 3 Histidine phosphatase superfamily (branch 1) Dfp1_Him1_M PF08630.10 KOH00906.1 - 2.7e-43 147.2 0.0 2.7e-43 147.2 0.0 3.6 3 1 1 4 4 4 1 Dfp1/Him1, central region zf-DBF PF07535.12 KOH00906.1 - 1.2e-20 73.3 1.0 3e-20 72.0 1.0 1.8 1 0 0 1 1 1 1 DBF zinc finger HHH_8 PF14716.6 KOH00906.1 - 0.0024 18.2 0.1 0.0091 16.4 0.1 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix domain UQ_con PF00179.26 KOH00907.1 - 8.6e-45 151.8 0.1 1.2e-44 151.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Recep_L_domain PF01030.24 KOH00908.1 - 1.8e-07 31.3 18.0 0.00045 20.3 0.6 4.5 1 1 2 3 3 3 3 Receptor L domain LRR_9 PF14580.6 KOH00908.1 - 0.0068 15.9 1.7 0.015 14.8 0.6 2.1 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KOH00908.1 - 4.7 7.8 25.7 1.1 9.8 1.4 5.5 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) PFU PF09070.11 KOH00909.1 - 0.0055 17.0 3.3 0.084 13.1 0.2 2.3 2 0 0 2 2 2 2 PFU (PLAA family ubiquitin binding) DUF3242 PF11586.8 KOH00909.1 - 0.007 16.1 0.2 0.01 15.5 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3242) Yos9_DD PF17880.1 KOH00910.1 - 1.7e-38 131.6 0.3 4.5e-38 130.3 0.3 1.8 1 0 0 1 1 1 1 Yos9 dimerzation domain PRKCSH PF07915.13 KOH00910.1 - 3.3e-09 37.6 1.5 7.1e-09 36.6 0.3 2.3 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein TSNAXIP1_N PF15739.5 KOH00910.1 - 0.23 11.9 1.6 0.42 11.0 0.4 2.1 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus PGAP1 PF07819.13 KOH00911.1 - 7.2e-07 29.2 0.0 3.6e-06 26.9 0.0 2.0 1 1 1 2 2 2 1 PGAP1-like protein Palm_thioest PF02089.15 KOH00911.1 - 5.4e-06 26.4 0.0 3.3e-05 23.9 0.0 2.0 1 1 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 KOH00911.1 - 2.2e-05 24.2 0.0 7e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF676 PF05057.14 KOH00911.1 - 4e-05 23.2 0.0 8.6e-05 22.1 0.0 1.5 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 KOH00911.1 - 0.00092 19.9 0.0 0.0017 19.0 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.11 KOH00911.1 - 0.0014 18.1 0.0 0.0095 15.3 0.0 2.3 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) LCAT PF02450.15 KOH00911.1 - 0.003 16.8 0.0 0.0045 16.2 0.0 1.5 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 KOH00911.1 - 0.016 14.7 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase_3 PF01764.25 KOH00911.1 - 0.089 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) UQ_con PF00179.26 KOH00912.1 - 5.9e-44 149.1 0.1 6.6e-44 149.0 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOH00912.1 - 0.00088 19.0 0.0 0.001 18.8 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KOH00912.1 - 0.0044 17.3 0.0 0.0072 16.6 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 KOH00912.1 - 0.011 15.6 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 UEV domain CBF PF03914.17 KOH00913.1 - 1.1e-49 168.7 0.3 1.1e-49 168.7 0.3 4.5 4 1 0 4 4 4 1 CBF/Mak21 family Pyridox_ox_2 PF12900.7 KOH00913.1 - 0.52 10.3 0.0 0.52 10.3 0.0 3.0 3 0 0 3 3 3 0 Pyridoxamine 5'-phosphate oxidase ABC_tran PF00005.27 KOH00914.1 - 5.3e-23 82.1 0.0 9.2e-14 52.1 0.0 2.7 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 KOH00914.1 - 2.1e-08 34.3 0.1 0.00048 20.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 KOH00914.1 - 0.00012 22.2 0.0 0.11 12.8 0.0 2.6 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 KOH00914.1 - 0.00092 18.9 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 KOH00914.1 - 0.038 14.5 0.1 0.48 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain Ploopntkinase1 PF18748.1 KOH00914.1 - 0.11 12.0 0.0 0.67 9.5 0.0 2.1 2 0 0 2 2 2 0 P-loop Nucleotide Kinase1 cobW PF02492.19 KOH00914.1 - 0.19 11.3 0.0 0.42 10.2 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Aminotran_1_2 PF00155.21 KOH00915.1 - 9.7e-72 242.1 0.0 1.2e-71 241.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KOH00915.1 - 0.0093 15.0 0.0 0.018 14.0 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Cofilin_ADF PF00241.20 KOH00916.1 - 3e-18 65.8 0.1 3.7e-18 65.5 0.1 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Ribosomal_S13_N PF08069.12 KOH00917.1 - 5.7e-26 90.3 0.1 1.1e-25 89.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 KOH00917.1 - 6.6e-15 55.1 0.8 1.1e-14 54.4 0.4 1.5 2 0 0 2 2 2 1 Ribosomal protein S15 Complex1_LYR PF05347.15 KOH00918.1 - 0.00026 21.0 0.8 0.0011 19.0 0.5 2.2 2 0 0 2 2 2 1 Complex 1 protein (LYR family) NikR_C PF08753.11 KOH00918.1 - 0.16 12.2 0.1 0.33 11.2 0.1 1.5 1 0 0 1 1 1 0 NikR C terminal nickel binding domain YlbD_coat PF14071.6 KOH00918.1 - 1.8 8.8 6.5 0.74 10.1 0.6 2.3 2 0 0 2 2 2 0 Putative coat protein RPAP2_Rtr1 PF04181.13 KOH00919.1 - 1.7e-08 34.6 1.6 1.4e-05 25.3 0.0 2.6 1 1 1 2 2 2 2 Rtr1/RPAP2 family Y_phosphatase2 PF03162.13 KOH00920.1 - 1.1e-60 204.0 1.8 1.4e-60 203.7 1.8 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family dsRBD2 PF17842.1 KOH00920.1 - 0.00095 19.4 0.2 0.0017 18.6 0.2 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding domain 2 BSD PF03909.17 KOH00921.1 - 9.2e-14 51.2 0.1 9.2e-14 51.2 0.1 2.9 3 1 0 3 3 3 1 BSD domain UCH PF00443.29 KOH00922.1 - 8.3e-63 212.3 0.5 8.3e-63 212.3 0.5 3.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOH00922.1 - 7.6e-23 81.6 0.5 7.6e-23 81.6 0.5 4.2 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 KOH00922.1 - 6e-06 26.7 0.0 2.2e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain DUF4588 PF15251.6 KOH00922.1 - 2.4 7.9 12.2 3.3 7.4 0.2 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4588) Zn-ribbon_8 PF09723.10 KOH00922.1 - 2.4 8.3 4.4 24 5.1 1.9 2.8 2 0 0 2 2 2 0 Zinc ribbon domain Acetyltransf_1 PF00583.25 KOH00924.1 - 5.4e-23 81.4 0.0 6.7e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOH00924.1 - 5.3e-11 42.5 0.0 7e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOH00924.1 - 4.5e-06 27.0 0.0 6.5e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 KOH00924.1 - 0.0031 17.0 0.0 0.0038 16.7 0.0 1.2 1 0 0 1 1 1 1 Putative acetyl-transferase FR47 PF08445.10 KOH00924.1 - 0.0075 16.2 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 KOH00924.1 - 0.033 14.3 0.0 0.35 11.0 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KOH00924.1 - 0.051 13.7 0.1 0.074 13.2 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PAP2_3 PF14378.6 KOH00925.1 - 1.3e-12 47.9 12.9 8.9e-09 35.3 4.8 2.5 2 0 0 2 2 2 2 PAP2 superfamily PAP2 PF01569.21 KOH00925.1 - 3.9e-12 46.1 7.3 4.2e-07 29.8 0.0 3.5 3 1 0 3 3 3 2 PAP2 superfamily Plasmod_dom_1 PF09715.10 KOH00925.1 - 0.12 12.5 2.0 1.6 8.8 0.1 2.7 2 0 0 2 2 2 0 Plasmodium protein of unknown function (Plasmod_dom_1) SR-25 PF10500.9 KOH00925.1 - 4.2 6.9 6.0 6.8 6.2 6.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ACP53EA PF06313.11 KOH00926.1 - 0.023 14.9 0.2 0.035 14.3 0.2 1.2 1 0 0 1 1 1 0 Drosophila ACP53EA protein Glyco_transf_20 PF00982.21 KOH00927.1 - 1e-157 525.7 4.1 1.4e-157 525.2 4.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 KOH00927.1 - 2.9e-86 288.4 0.0 5e-86 287.6 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Metallophos PF00149.28 KOH00928.1 - 4.2e-39 135.2 0.1 5.2e-39 134.9 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOH00928.1 - 0.0056 16.9 0.0 0.0083 16.3 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain 8TM_micro PF17028.5 KOH00928.1 - 0.13 11.9 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 8TM Microsporidial transmembrane domain Glyco_hydro_65N PF03636.15 KOH00928.1 - 0.18 11.4 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain ATPase PF06745.13 KOH00929.1 - 1.6e-07 30.9 0.2 3.2e-07 30.0 0.2 1.6 1 1 0 1 1 1 1 KaiC Rad51 PF08423.11 KOH00929.1 - 8.6e-07 28.5 0.0 1.2e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Rad51 AAA_18 PF13238.6 KOH00929.1 - 0.00026 21.5 0.1 0.00098 19.7 0.0 2.0 1 1 1 2 2 2 1 AAA domain DnaB_C PF03796.15 KOH00929.1 - 0.053 12.9 0.1 0.21 10.9 0.0 1.8 2 1 0 2 2 2 0 DnaB-like helicase C terminal domain Hema_stalk PF08720.10 KOH00929.1 - 0.12 12.1 0.1 0.86 9.3 0.0 2.1 1 1 1 2 2 2 0 Influenza C hemagglutinin stalk AAA_25 PF13481.6 KOH00929.1 - 0.17 11.4 0.0 0.85 9.2 0.0 1.9 1 1 0 1 1 1 0 AAA domain Fer2_4 PF13510.6 KOH00930.1 - 0.095 12.8 2.0 8.5 6.5 0.1 2.9 2 1 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain SHIRT PF18655.1 KOH00930.1 - 0.79 10.3 5.8 15 6.3 0.1 3.1 3 0 0 3 3 3 0 SHIRT domain MH2 PF03166.14 KOH00930.1 - 3.6 7.8 5.7 4.5 7.5 0.3 2.3 1 1 1 2 2 2 0 MH2 domain Tafi-CsgC PF10610.9 KOH00930.1 - 7.4 6.8 12.7 0.38 11.0 0.6 3.0 3 0 0 3 3 3 0 Thin aggregative fimbriae synthesis protein SWIM PF04434.17 KOH00931.1 - 0.0087 15.7 4.7 1.5 8.6 0.2 2.4 2 0 0 2 2 2 2 SWIM zinc finger Pet100 PF09803.9 KOH00932.1 - 6.4e-10 39.4 1.4 6.6e-10 39.4 0.2 1.6 2 0 0 2 2 2 1 Pet100 GvpL_GvpF PF06386.11 KOH00932.1 - 0.054 13.4 0.5 0.073 13.0 0.5 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF ATPase_gene1 PF09527.10 KOH00932.1 - 0.18 12.0 0.0 0.26 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Tfb5 PF06331.12 KOH00933.1 - 1.1e-25 89.4 0.3 1.2e-25 89.2 0.3 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Clathrin PF00637.20 KOH00934.1 - 1.6e-34 118.8 2.4 1.3e-33 115.9 0.3 2.5 2 0 0 2 2 2 1 Region in Clathrin and VPS Vps39_1 PF10366.9 KOH00934.1 - 0.00035 20.8 0.3 0.0016 18.7 0.0 2.2 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 WD40 PF00400.32 KOH00934.1 - 0.003 18.4 0.3 0.016 16.1 0.2 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat Cwf_Cwc_15 PF04889.12 KOH00934.1 - 2.9 7.6 16.4 7.4 6.2 16.4 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DDE_1 PF03184.19 KOH00935.1 - 6.8e-71 237.5 3.8 6.8e-71 237.5 3.8 2.2 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KOH00935.1 - 2.7e-15 56.1 0.2 2.7e-15 56.1 0.2 2.4 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_ABP1_N PF18107.1 KOH00935.1 - 6.6e-05 22.5 0.3 0.00022 20.9 0.2 2.0 2 0 0 2 2 2 1 Fission yeast centromere protein N-terminal domain Stn1 PF10451.9 KOH00936.1 - 4.4e-48 163.4 2.0 8e-48 162.6 2.0 1.3 1 0 0 1 1 1 1 Telomere regulation protein Stn1 Stn1_C PF12659.7 KOH00936.1 - 2.6e-39 133.9 1.2 2.6e-39 133.9 1.2 2.1 2 0 0 2 2 2 1 Telomere capping C-terminal wHTH Methyltransf_8 PF05148.15 KOH00937.1 - 4.4e-67 226.1 3.1 1.1e-64 218.4 0.2 2.9 1 1 1 2 2 2 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 KOH00937.1 - 9.9e-09 35.7 0.0 3.7e-07 30.7 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOH00937.1 - 2.5e-05 24.9 0.0 0.00028 21.5 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOH00937.1 - 0.0012 18.6 0.1 0.021 14.6 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOH00937.1 - 0.34 10.9 0.0 0.34 10.9 0.0 2.9 3 1 0 3 3 3 0 Methyltransferase domain CDC45 PF02724.14 KOH00937.1 - 3.5 5.8 11.1 6.3 5.0 11.1 1.3 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 KOH00937.1 - 9.4 4.9 10.5 14 4.3 10.5 1.2 1 0 0 1 1 1 0 Presenilin DUF846 PF05832.12 KOH00938.1 - 4.4e-46 156.4 10.0 5.3e-46 156.1 10.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) SecE PF00584.20 KOH00940.1 - 6.1e-12 45.3 0.1 7.9e-12 44.9 0.1 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Coiled-coil_56 PF09813.9 KOH00940.1 - 0.011 15.8 0.0 0.013 15.5 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 Nop52 PF05997.12 KOH00941.1 - 2.1e-71 240.2 7.8 2.5e-71 239.9 7.8 1.1 1 0 0 1 1 1 1 Nucleolar protein,Nop52 TAN PF11640.8 KOH00941.1 - 0.00091 19.4 0.6 0.0033 17.6 0.2 2.0 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair IFRD PF05004.13 KOH00941.1 - 0.21 10.7 0.0 0.21 10.7 0.0 2.6 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) CENP-B_dimeris PF09026.10 KOH00941.1 - 0.98 9.9 13.4 1.6 9.2 2.7 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF4611 PF15387.6 KOH00941.1 - 4.3 7.6 10.3 1.2 9.4 2.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Slu7 PF11708.8 KOH00942.1 - 1.1e-15 58.2 22.9 1.1e-15 58.2 22.9 3.2 2 1 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC PF00098.23 KOH00942.1 - 0.00025 21.0 4.4 0.0004 20.3 4.4 1.3 1 0 0 1 1 1 1 Zinc knuckle SPX PF03105.19 KOH00943.1 - 0.00064 19.7 0.8 0.00064 19.7 0.8 3.9 3 1 0 3 3 3 2 SPX domain Saf_2TM PF18303.1 KOH00943.1 - 0.098 12.2 2.9 0.22 11.1 2.9 1.5 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain PQ-loop PF04193.14 KOH00944.1 - 1.2e-22 79.5 11.4 2.7e-18 65.5 2.1 2.6 2 0 0 2 2 2 2 PQ loop repeat ABC2_membrane_5 PF13346.6 KOH00944.1 - 0.33 10.5 23.3 0.052 13.1 10.6 2.2 1 1 1 2 2 2 0 ABC-2 family transporter protein Syndecan PF01034.20 KOH00944.1 - 3.5 7.6 0.0 3.5 7.6 0.0 3.5 5 0 0 5 5 5 0 Syndecan domain ABC_tran PF00005.27 KOH00945.1 - 1.8e-35 122.4 0.0 1.2e-16 61.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 KOH00945.1 - 2.8e-14 52.7 5.0 6.3e-14 51.5 5.0 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 KOH00945.1 - 3.5e-11 43.5 8.2 0.044 13.6 0.1 4.3 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOH00945.1 - 3.3e-09 36.5 2.6 0.033 13.6 0.4 4.0 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain Fer4 PF00037.27 KOH00945.1 - 3.4e-07 29.8 3.5 3.4e-07 29.8 3.5 2.5 3 0 0 3 3 2 1 4Fe-4S binding domain AAA_16 PF13191.6 KOH00945.1 - 9.7e-07 29.3 0.0 0.0028 18.0 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA PF00004.29 KOH00945.1 - 2e-06 28.3 0.0 0.0075 16.7 0.0 2.6 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 KOH00945.1 - 6.6e-06 26.1 0.0 0.046 13.6 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 KOH00945.1 - 1e-05 25.8 0.0 0.0027 18.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 KOH00945.1 - 1.8e-05 24.6 2.2 0.29 10.8 0.0 3.1 2 2 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 KOH00945.1 - 4.4e-05 23.1 0.2 0.18 11.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Rad17 PF03215.15 KOH00945.1 - 6.4e-05 23.0 0.2 0.4 10.6 0.1 2.6 2 1 0 2 2 2 2 Rad17 P-loop domain Fer4_6 PF12837.7 KOH00945.1 - 0.00078 19.4 3.1 0.00078 19.4 3.1 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_7 PF12838.7 KOH00945.1 - 0.0012 19.3 0.4 0.0012 19.3 0.4 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain NB-ARC PF00931.22 KOH00945.1 - 0.0017 17.6 0.0 0.58 9.3 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain NACHT PF05729.12 KOH00945.1 - 0.0019 18.2 1.5 0.14 12.0 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 KOH00945.1 - 0.002 18.3 0.0 0.61 10.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOH00945.1 - 0.0022 17.7 0.3 0.17 11.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 KOH00945.1 - 0.0023 18.0 0.1 0.96 9.5 0.0 3.0 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 KOH00945.1 - 0.0024 18.3 0.1 0.95 9.9 0.0 3.0 4 0 0 4 4 2 1 RNA helicase AAA_24 PF13479.6 KOH00945.1 - 0.0026 17.5 0.2 1 9.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain Fer4_21 PF14697.6 KOH00945.1 - 0.0037 17.4 12.8 0.0098 16.0 12.8 1.8 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_28 PF13521.6 KOH00945.1 - 0.0038 17.5 0.1 1.5 9.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 KOH00945.1 - 0.0047 17.4 6.1 0.021 15.3 0.0 2.8 2 1 0 2 2 2 1 AAA domain SRP54 PF00448.22 KOH00945.1 - 0.0052 16.4 2.7 0.23 11.0 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_2 PF12797.7 KOH00945.1 - 0.0056 16.7 0.8 0.0056 16.7 0.8 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_10 PF13237.6 KOH00945.1 - 0.0067 16.5 1.6 0.0067 16.5 1.6 2.4 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 KOH00945.1 - 0.0076 16.4 11.6 0.017 15.3 11.6 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 KOH00945.1 - 0.012 16.5 0.2 0.012 16.5 0.2 2.7 2 1 1 3 3 1 0 4Fe-4S double cluster binding domain AAA_18 PF13238.6 KOH00945.1 - 0.013 16.0 0.0 9.4 6.8 0.0 2.9 3 0 0 3 3 2 0 AAA domain AAA_7 PF12775.7 KOH00945.1 - 0.015 14.9 0.3 0.15 11.6 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region DLIC PF05783.11 KOH00945.1 - 0.022 13.6 0.0 0.046 12.5 0.0 1.4 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_5 PF07728.14 KOH00945.1 - 0.025 14.6 1.6 0.16 11.9 0.1 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 KOH00945.1 - 0.033 14.2 0.1 0.41 10.6 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 KOH00945.1 - 0.034 14.2 0.1 6.1 7.0 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Fer4_17 PF13534.6 KOH00945.1 - 0.054 14.1 0.2 0.054 14.1 0.2 2.5 2 0 0 2 2 1 0 4Fe-4S dicluster domain Thymidylate_kin PF02223.17 KOH00945.1 - 0.072 12.8 0.5 18 5.0 0.1 3.0 3 0 0 3 3 3 0 Thymidylate kinase VirE PF05272.11 KOH00945.1 - 0.079 12.7 0.0 2.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E AAA_13 PF13166.6 KOH00945.1 - 0.097 11.3 0.1 0.34 9.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 KOH00945.1 - 0.12 11.5 0.0 4.4 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Septin PF00735.18 KOH00945.1 - 0.15 11.3 0.0 4 6.6 0.0 2.2 2 0 0 2 2 2 0 Septin SbcCD_C PF13558.6 KOH00945.1 - 0.15 12.3 0.0 35 4.7 0.0 2.9 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Fer4_8 PF13183.6 KOH00945.1 - 0.16 12.5 0.1 0.16 12.5 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain NTPase_1 PF03266.15 KOH00945.1 - 0.35 10.8 1.7 2.5 8.0 0.1 2.6 2 0 0 2 2 2 0 NTPase MobB PF03205.14 KOH00945.1 - 0.51 10.2 1.7 1.4 8.8 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Fer4_4 PF12800.7 KOH00945.1 - 1 10.0 14.9 0.45 11.2 3.0 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain PhoLip_ATPase_C PF16212.5 KOH00946.1 - 5.7e-76 255.6 25.9 5.7e-76 255.6 25.9 2.6 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KOH00946.1 - 2.1e-17 62.6 0.5 6.2e-17 61.0 0.5 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 KOH00946.1 - 7.6e-12 45.2 0.0 3.3e-11 43.1 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOH00946.1 - 7.1e-10 39.5 4.8 2e-06 28.3 0.8 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KOH00946.1 - 1.4e-05 24.7 0.3 5.1e-05 22.9 0.0 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KOH00946.1 - 0.0014 18.4 0.2 0.0041 16.9 0.2 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4131 PF13567.6 KOH00946.1 - 0.72 9.5 3.7 0.53 9.9 1.4 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) JmjC PF02373.22 KOH00947.1 - 4.2e-33 114.2 2.2 4.9e-33 114.0 0.3 2.2 2 0 0 2 2 2 1 JmjC domain, hydroxylase JmjN PF02375.17 KOH00947.1 - 5.1e-10 39.1 1.6 9.2e-10 38.3 0.7 1.9 2 0 0 2 2 2 1 jmjN domain zf-H2C2_2 PF13465.6 KOH00947.1 - 1.7e-05 25.0 6.2 1.7e-05 25.0 6.2 2.5 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOH00947.1 - 3.7e-05 24.2 14.3 0.024 15.5 4.5 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KOH00947.1 - 7.6e-05 22.9 15.3 0.024 15.1 2.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 KOH00947.1 - 0.00087 19.2 9.7 0.00097 19.1 3.4 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KOH00947.1 - 0.0046 17.0 2.6 0.011 15.9 2.6 1.6 1 0 0 1 1 1 1 Zinc ribbon domain zf-met PF12874.7 KOH00947.1 - 0.04 14.3 6.0 0.81 10.2 0.3 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Zn_ribbon_SprT PF17283.2 KOH00947.1 - 0.19 11.6 2.4 11 6.0 0.1 2.5 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf_UBZ PF18439.1 KOH00947.1 - 0.24 11.0 3.0 4.1 7.1 0.2 2.6 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_jaz PF12171.8 KOH00947.1 - 0.29 11.5 9.3 0.51 10.7 4.2 2.6 1 1 1 2 2 2 0 Zinc-finger double-stranded RNA-binding ASD2 PF08687.11 KOH00947.1 - 2.2 7.8 8.8 0.11 12.1 2.0 2.2 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 MutS_V PF00488.21 KOH00948.1 - 4.3e-63 212.8 1.7 7.2e-63 212.0 0.9 1.8 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 KOH00948.1 - 4.7e-35 121.6 0.6 4.7e-35 121.6 0.6 2.3 2 1 0 2 2 2 1 MutS domain III MutS_I PF01624.20 KOH00948.1 - 1.8e-33 115.1 0.0 5.4e-33 113.6 0.0 1.9 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.18 KOH00948.1 - 8.1e-19 67.8 0.6 2.6e-18 66.1 0.6 2.0 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 KOH00948.1 - 7.6e-12 45.7 0.7 2.5e-11 44.0 0.0 2.2 2 0 0 2 2 2 1 MutS domain II AAA_27 PF13514.6 KOH00948.1 - 0.016 14.8 0.0 0.059 12.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOH00948.1 - 0.064 13.8 3.5 5 7.7 0.0 3.9 3 0 0 3 3 3 0 ABC transporter AAA_29 PF13555.6 KOH00948.1 - 0.13 12.0 0.0 0.43 10.4 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Glutaredoxin PF00462.24 KOH00949.1 - 2.7e-19 69.1 0.0 8.7e-16 57.9 0.0 2.6 2 0 0 2 2 2 2 Glutaredoxin Thioredoxin PF00085.20 KOH00949.1 - 4.3e-14 52.3 0.0 1.1e-13 51.0 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KOH00949.1 - 6.2e-05 23.3 0.0 0.0093 16.3 0.0 2.6 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 KOH00949.1 - 0.00059 20.3 0.1 0.023 15.2 0.0 2.7 2 2 1 3 3 3 1 Thioredoxin-like domain AhpC-TSA PF00578.21 KOH00949.1 - 0.0017 18.3 0.0 0.0032 17.4 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family OST3_OST6 PF04756.13 KOH00949.1 - 0.0021 17.4 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DNA_pol_phi PF04931.13 KOH00949.1 - 0.011 13.8 2.1 0.017 13.2 2.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 KOH00949.1 - 0.017 14.8 1.8 0.032 13.9 1.8 1.4 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.10 KOH00949.1 - 0.03 14.7 5.8 0.06 13.7 5.8 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain TRAP_alpha PF03896.16 KOH00949.1 - 0.032 13.4 0.7 0.043 13.0 0.7 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit D123 PF07065.14 KOH00949.1 - 0.04 13.1 0.4 0.057 12.6 0.4 1.2 1 0 0 1 1 1 0 D123 Thioredoxin_7 PF13899.6 KOH00949.1 - 0.05 13.8 0.0 0.12 12.6 0.0 1.6 2 0 0 2 2 1 0 Thioredoxin-like DUF4611 PF15387.6 KOH00949.1 - 0.055 13.7 5.3 0.11 12.7 5.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Radial_spoke PF04712.12 KOH00949.1 - 0.11 11.4 2.8 0.15 11.0 2.8 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein DIM1 PF02966.16 KOH00949.1 - 0.14 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Mitosis protein DIM1 MscS_TM PF12794.7 KOH00949.1 - 0.26 10.1 0.4 0.32 9.8 0.4 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 NOA36 PF06524.12 KOH00949.1 - 0.48 9.7 7.6 0.72 9.1 7.6 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4820 PF16091.5 KOH00949.1 - 0.57 9.5 2.8 0.82 9.0 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Sporozoite_P67 PF05642.11 KOH00949.1 - 0.7 7.9 2.9 0.91 7.5 2.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2457 PF10446.9 KOH00949.1 - 3.6 6.6 9.5 5 6.2 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) 14-3-3 PF00244.20 KOH00950.1 - 1.7e-106 354.7 4.9 2.3e-106 354.3 4.9 1.2 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.11 KOH00950.1 - 0.0036 17.3 0.7 0.0099 15.9 0.7 1.7 1 0 0 1 1 1 1 Flagellar protein FlaF FRG PF08867.11 KOH00950.1 - 0.62 11.1 2.8 0.41 11.6 0.2 2.2 3 1 0 3 3 3 0 FRG domain COPI_assoc PF08507.10 KOH00951.1 - 3.1e-39 134.0 7.6 3.5e-39 133.8 7.6 1.0 1 0 0 1 1 1 1 COPI associated protein Peptidase_M24 PF00557.24 KOH00952.1 - 6.7e-07 29.2 0.0 2.6e-06 27.3 0.0 2.0 2 1 0 2 2 2 1 Metallopeptidase family M24 Ste5_C PF12194.8 KOH00953.1 - 4.1e-84 281.3 4.5 4.1e-84 281.3 4.5 1.6 2 0 0 2 2 2 1 Protein kinase Fus3-binding Ste5 PF11610.8 KOH00953.1 - 3.8e-21 74.6 2.9 7.4e-21 73.7 2.9 1.5 1 0 0 1 1 1 1 Scaffold protein Ste5, Fus3-binding region zf-RING_2 PF13639.6 KOH00953.1 - 0.0064 16.8 3.1 0.014 15.7 3.1 1.6 1 0 0 1 1 1 1 Ring finger domain PH_10 PF15411.6 KOH00953.1 - 0.019 15.2 0.1 0.069 13.4 0.1 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain Zn_ribbon_17 PF17120.5 KOH00953.1 - 0.054 13.1 0.1 0.1 12.2 0.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 KOH00953.1 - 1.1 9.3 3.9 2.8 8.0 3.9 1.8 1 0 0 1 1 1 0 RING-type zinc-finger PH_4 PF15404.6 KOH00954.1 - 3.4e-73 245.4 0.0 7.9e-73 244.2 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Spo7_2_N PF15407.6 KOH00954.1 - 7.3e-26 89.6 0.2 2.4e-25 87.9 0.2 2.0 1 0 0 1 1 1 1 Sporulation protein family 7 PH PF00169.29 KOH00954.1 - 0.0062 17.0 1.4 12 6.5 0.0 4.4 4 0 0 4 4 4 2 PH domain PH_12 PF16457.5 KOH00954.1 - 0.0092 16.5 0.1 0.049 14.2 0.1 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 KOH00954.1 - 0.1 12.4 0.8 1.5 8.7 0.3 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain Serinc PF03348.15 KOH00955.1 - 8.8e-139 463.1 16.4 1.1e-138 462.8 16.4 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) TMEM173 PF15009.6 KOH00955.1 - 0.13 11.4 7.0 0.024 13.8 2.6 1.9 2 0 0 2 2 2 0 Transmembrane protein 173 OCIA PF07051.11 KOH00955.1 - 0.17 11.9 1.2 2.8 8.1 0.0 2.8 2 1 1 3 3 3 0 Ovarian carcinoma immunoreactive antigen (OCIA) DUF872 PF05915.12 KOH00955.1 - 0.47 10.6 3.6 0.73 10.0 0.2 2.7 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Actin PF00022.19 KOH00956.1 - 7.5e-10 38.0 0.0 8.2e-08 31.3 0.0 2.2 2 0 0 2 2 2 2 Actin EMP70 PF02990.16 KOH00957.1 - 2.8e-190 633.4 11.6 2.8e-190 633.4 11.6 1.5 1 1 1 2 2 2 1 Endomembrane protein 70 Tmpp129 PF10272.9 KOH00957.1 - 0.045 13.0 0.4 0.1 11.9 0.4 1.6 1 0 0 1 1 1 0 Putative transmembrane protein precursor TRAPPC-Trs85 PF12739.7 KOH00958.1 - 2.4e-109 366.0 4.1 2.4e-109 366.0 4.1 1.5 2 0 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit UPF0560 PF10577.9 KOH00959.1 - 3.8 5.9 8.3 6 5.2 8.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Aminotran_1_2 PF00155.21 KOH00960.1 - 1e-36 126.9 0.0 1.5e-36 126.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II PPR_3 PF13812.6 KOH00960.1 - 0.023 14.8 0.0 0.37 10.9 0.0 2.6 2 0 0 2 2 2 0 Pentatricopeptide repeat domain Glucosaminidase PF01832.20 KOH00960.1 - 0.068 13.7 0.0 0.85 10.2 0.0 2.3 2 0 0 2 2 2 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase Securin PF04856.13 KOH00961.1 - 2.8e-52 178.0 10.9 3.5e-52 177.7 10.9 1.1 1 0 0 1 1 1 1 Securin sister-chromatid separation inhibitor Ribosomal_L34 PF00468.17 KOH00962.1 - 6.9e-20 70.7 5.6 6.9e-20 70.7 5.6 1.8 1 1 1 2 2 2 1 Ribosomal protein L34 Ribosomal_L1 PF00687.21 KOH00963.1 - 4.6e-26 91.8 0.1 5.7e-26 91.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family SUI1 PF01253.22 KOH00964.1 - 1.8e-18 66.8 0.1 6.2e-18 65.1 0.1 2.0 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 KOH00964.1 - 1.2e-08 35.5 1.4 3.8e-08 33.9 1.4 1.9 1 0 0 1 1 1 1 Pre-PUA-like domain SWIB PF02201.18 KOH00964.1 - 0.00012 21.9 0.3 0.00031 20.5 0.3 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain MCPsignal PF00015.21 KOH00964.1 - 0.049 13.4 1.3 0.12 12.2 1.3 1.5 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain ANAPC4 PF12896.7 KOH00965.1 - 2.9e-24 85.7 0.5 4.3e-24 85.2 0.5 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 MFS_1 PF07690.16 KOH00966.1 - 9.5e-22 77.4 42.1 3.5e-21 75.5 17.2 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOH00966.1 - 8.8e-13 47.9 7.2 8.8e-13 47.9 7.2 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter UPF1_Zn_bind PF09416.10 KOH00966.1 - 0.23 11.4 0.6 0.48 10.4 0.1 1.8 2 0 0 2 2 2 0 RNA helicase (UPF2 interacting domain) IFP_35_N PF07334.13 KOH00966.1 - 0.81 9.8 4.6 15 5.7 0.1 2.5 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DivIC PF04977.15 KOH00966.1 - 2.4 8.0 4.2 8.8 6.2 4.2 1.9 1 0 0 1 1 1 0 Septum formation initiator TRM PF02005.16 KOH00968.1 - 2.3e-155 517.5 0.1 2.6e-155 517.3 0.1 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 KOH00968.1 - 4.5e-06 26.6 0.1 8.4e-06 25.7 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 KOH00968.1 - 0.053 13.2 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Conserved hypothetical protein 95 CPSF100_C PF13299.6 KOH00968.1 - 0.084 13.0 0.2 0.17 12.1 0.2 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CpXC PF14353.6 KOH00968.1 - 0.1 12.6 0.1 0.91 9.6 0.1 2.4 1 1 0 1 1 1 0 CpXC protein PrmA PF06325.13 KOH00968.1 - 0.21 10.9 1.0 0.64 9.4 0.7 1.8 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) CBFD_NFYB_HMF PF00808.23 KOH00969.1 - 0.00081 19.6 0.5 0.0017 18.6 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pol_alpha_B_N PF08418.10 KOH00969.1 - 0.013 15.5 2.1 0.018 15.0 2.1 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Histone PF00125.24 KOH00969.1 - 0.38 11.1 2.8 0.7 10.3 0.0 2.2 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 eIF-3c_N PF05470.12 KOH00969.1 - 0.9 7.8 5.9 1.1 7.5 5.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Pkinase PF00069.25 KOH00970.1 - 6.4e-67 225.7 7.6 1.1e-65 221.6 3.1 2.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH00970.1 - 1.7e-41 142.2 0.9 1.1e-39 136.3 0.9 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 KOH00970.1 - 2.8e-18 65.4 0.0 5.9e-18 64.4 0.0 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 KOH00970.1 - 3e-07 30.0 0.0 6.7e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KOH00970.1 - 2.5e-05 23.4 2.6 0.0055 15.7 0.2 2.5 2 0 0 2 2 2 2 Haspin like kinase domain Kdo PF06293.14 KOH00970.1 - 0.00039 19.8 0.2 0.00078 18.8 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOH00970.1 - 0.00048 20.1 0.0 0.16 11.9 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOH00970.1 - 0.0033 16.2 0.0 0.0033 16.2 0.0 2.8 4 0 0 4 4 4 1 Fungal protein kinase RIO1 PF01163.22 KOH00970.1 - 0.087 12.4 0.9 0.26 10.9 0.3 2.1 2 0 0 2 2 2 0 RIO1 family HLH PF00010.26 KOH00971.1 - 0.14 12.1 0.5 0.27 11.2 0.5 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain DUF2841 PF11001.8 KOH00972.1 - 3.5e-35 120.7 1.5 6.5e-35 119.9 1.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Cnd1 PF12717.7 KOH00972.1 - 0.0005 20.1 2.1 0.00077 19.5 2.1 1.2 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 ALMT PF11744.8 KOH00972.1 - 0.042 12.7 0.1 0.056 12.3 0.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Abhydrolase_1 PF00561.20 KOH00973.1 - 5.5e-16 59.0 0.0 1e-11 45.0 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOH00973.1 - 6.4e-07 28.9 0.0 6.5e-06 25.6 0.0 2.3 2 1 1 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOH00973.1 - 1e-06 29.6 0.0 1.9e-06 28.6 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.11 KOH00973.1 - 1.4e-05 24.6 0.2 0.017 14.5 0.0 2.5 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.20 KOH00973.1 - 0.0017 18.1 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 Putative esterase LIDHydrolase PF10230.9 KOH00973.1 - 0.0057 16.2 0.0 0.0089 15.6 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ndr PF03096.14 KOH00973.1 - 0.007 15.1 0.0 0.1 11.3 0.0 2.2 2 0 0 2 2 2 1 Ndr family Ser_hydrolase PF06821.13 KOH00973.1 - 0.013 15.4 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Peptidase_S9 PF00326.21 KOH00973.1 - 0.024 14.1 0.0 3.3 7.1 0.0 2.6 3 0 0 3 3 3 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 KOH00973.1 - 0.091 11.7 0.0 0.16 10.8 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme PGAP1 PF07819.13 KOH00973.1 - 0.12 12.1 0.0 0.25 11.0 0.0 1.5 1 1 0 1 1 1 0 PGAP1-like protein DHHC PF01529.20 KOH00974.1 - 1.2e-23 83.7 19.2 1.2e-23 83.7 19.2 2.8 2 2 0 2 2 2 1 DHHC palmitoyltransferase DUF936 PF06075.12 KOH00974.1 - 0.0081 15.1 0.1 0.011 14.7 0.1 1.1 1 0 0 1 1 1 1 Plant protein of unknown function (DUF936) DUF4064 PF13273.6 KOH00974.1 - 0.92 9.8 0.0 0.92 9.8 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF4064) EPSP_synthase PF00275.20 KOH00975.1 - 4.2e-149 496.8 0.0 7.2e-149 496.0 0.0 1.4 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 KOH00975.1 - 3.8e-99 331.1 0.1 6.2e-99 330.4 0.1 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 KOH00975.1 - 1.4e-59 202.1 0.0 3.7e-59 200.7 0.0 1.7 2 0 0 2 2 2 1 Type I 3-dehydroquinase SKI PF01202.22 KOH00975.1 - 1e-36 126.5 0.1 2.9e-36 125.0 0.0 1.8 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 KOH00975.1 - 1.6e-22 79.6 0.0 1.8e-21 76.2 0.0 2.6 2 0 0 2 2 2 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 KOH00975.1 - 3.9e-10 39.3 0.3 8.4e-10 38.3 0.3 1.6 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 KOH00975.1 - 5e-07 29.9 0.0 1.6e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Fe-ADH_2 PF13685.6 KOH00975.1 - 0.00014 21.7 0.0 0.00032 20.5 0.0 1.6 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase AAA_33 PF13671.6 KOH00975.1 - 0.00042 20.5 0.0 0.0014 18.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain Sacchrp_dh_NADP PF03435.18 KOH00975.1 - 0.022 15.0 0.0 0.097 12.9 0.0 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain AAA_14 PF13173.6 KOH00975.1 - 0.041 13.9 0.0 0.13 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 KOH00975.1 - 0.049 12.9 0.0 0.094 12.0 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase THF_DHG_CYH PF00763.23 KOH00975.1 - 0.063 13.5 0.0 0.23 11.8 0.0 1.9 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain DUF2610 PF11020.8 KOH00975.1 - 0.094 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2610) Zn_ribbon_17 PF17120.5 KOH00976.1 - 1.2e-22 79.3 11.7 2.9e-22 78.0 11.7 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 KOH00976.1 - 9.1e-07 29.5 22.1 1.4e-05 25.8 0.2 5.6 5 0 0 5 5 5 2 WD domain, G-beta repeat C1_2 PF03107.16 KOH00976.1 - 0.0029 17.9 7.1 0.0032 17.8 2.2 2.5 2 0 0 2 2 2 1 C1 domain RWD PF05773.22 KOH00976.1 - 0.0044 17.3 0.1 0.012 15.9 0.1 1.7 1 0 0 1 1 1 1 RWD domain zf-C3HC4_2 PF13923.6 KOH00976.1 - 0.006 16.4 5.9 0.014 15.2 5.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOH00976.1 - 0.0084 16.4 6.8 0.021 15.1 6.8 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 KOH00976.1 - 0.036 14.4 7.5 0.1 13.0 7.5 1.8 1 0 0 1 1 1 0 Ring finger domain zinc_ribbon_16 PF17034.5 KOH00976.1 - 0.51 10.6 8.7 0.45 10.7 6.0 2.4 2 0 0 2 2 2 0 Zinc-ribbon like family zf-RING_5 PF14634.6 KOH00976.1 - 1.5 8.9 10.0 3.6 7.6 10.0 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 KOH00976.1 - 6.6 6.7 9.0 16 5.4 9.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CH PF00307.31 KOH00977.1 - 8.6e-64 212.5 0.0 4.6e-22 78.3 0.0 3.1 3 0 0 3 3 3 3 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KOH00977.1 - 0.00022 21.0 0.0 0.1 12.4 0.0 2.8 3 0 0 3 3 3 2 CAMSAP CH domain CH_2 PF06294.11 KOH00977.1 - 0.00083 19.4 0.0 2 8.6 0.0 3.3 4 0 0 4 4 4 2 CH-like domain in sperm protein FIN1 PF17300.2 KOH00978.1 - 1.3e-92 309.7 15.5 1.3e-92 309.7 15.5 1.5 2 0 0 2 2 2 1 Filaments in between nuclei protein-1 5_nucleotid_C PF02872.18 KOH00978.1 - 0.062 13.5 0.0 0.12 12.6 0.0 1.5 1 1 0 1 1 1 0 5'-nucleotidase, C-terminal domain DUF3760 PF12586.8 KOH00979.1 - 0.012 15.7 0.2 0.048 13.8 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3760) F-box-like PF12937.7 KOH00979.1 - 0.05 13.5 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 F-box-like LRR_4 PF12799.7 KOH00979.1 - 0.21 12.1 12.3 0.21 12.1 0.1 5.1 6 0 0 6 6 6 0 Leucine Rich repeats (2 copies) BTB_2 PF02214.22 KOH00980.1 - 2e-10 40.9 0.4 3.1e-06 27.5 0.1 3.1 2 1 0 2 2 2 2 BTB/POZ domain Flocculin_t3 PF13928.6 KOH00981.1 - 1.3e-15 57.6 17.3 1.3e-15 57.6 17.3 2.9 3 0 0 3 3 3 1 Flocculin type 3 repeat Mucin PF01456.17 KOH00981.1 - 1.3 9.1 23.1 1.6 8.7 23.1 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein ABC_membrane PF00664.23 KOH00982.1 - 3.7e-94 315.4 31.4 7.6e-49 166.8 6.3 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOH00982.1 - 8.5e-48 162.4 0.2 4e-29 101.9 0.1 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOH00982.1 - 4.9e-08 32.7 6.3 0.0029 17.1 0.1 4.1 2 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain MTABC_N PF16185.5 KOH00982.1 - 8.8e-05 22.1 0.6 8.8e-05 22.1 0.6 2.5 3 0 0 3 3 3 1 Mitochondrial ABC-transporter N-terminal five TM region AAA_29 PF13555.6 KOH00982.1 - 0.00029 20.5 1.0 0.76 9.6 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KOH00982.1 - 0.00064 19.8 0.9 0.07 13.2 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_15 PF13175.6 KOH00982.1 - 0.0021 17.8 3.7 1.7 8.2 0.1 3.4 3 1 0 3 3 3 2 AAA ATPase domain AAA_16 PF13191.6 KOH00982.1 - 0.0029 18.0 0.3 1.6 9.1 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 KOH00982.1 - 0.0078 16.7 5.9 0.23 11.9 0.1 3.1 3 0 0 3 3 2 1 AAA domain RsgA_GTPase PF03193.16 KOH00982.1 - 0.012 15.5 0.0 6.5 6.6 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase AAA_25 PF13481.6 KOH00982.1 - 0.016 14.8 0.1 1.7 8.2 0.1 2.4 2 0 0 2 2 2 0 AAA domain TMEM132D_C PF15706.5 KOH00982.1 - 0.022 14.5 0.5 0.15 11.8 0.0 2.6 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term IstB_IS21 PF01695.17 KOH00982.1 - 0.053 13.2 0.0 1.6 8.4 0.0 2.8 2 0 0 2 2 2 0 IstB-like ATP binding protein Cytomega_TRL10 PF06084.11 KOH00982.1 - 0.082 12.9 0.8 0.37 10.8 0.1 2.4 3 0 0 3 3 2 0 Cytomegalovirus TRL10 protein AAA_7 PF12775.7 KOH00982.1 - 0.089 12.3 0.3 16 4.9 0.1 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_21 PF13304.6 KOH00982.1 - 0.12 12.2 5.6 4.9 6.9 0.2 3.4 2 1 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system cobW PF02492.19 KOH00982.1 - 0.25 10.9 2.1 0.62 9.6 0.3 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 KOH00982.1 - 0.38 11.0 4.7 10 6.4 0.4 3.5 3 1 0 3 3 3 0 AAA domain AAA_30 PF13604.6 KOH00982.1 - 0.38 10.4 2.2 24 4.6 0.2 2.8 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 KOH00982.1 - 0.47 10.7 2.2 33 4.7 0.0 3.0 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase Rgp1 PF08737.10 KOH00983.1 - 7.5e-104 348.2 5.9 7.5e-104 348.2 5.9 2.0 2 0 0 2 2 2 1 Rgp1 Arrestin_C PF02752.22 KOH00983.1 - 0.0038 17.7 3.3 0.047 14.1 0.2 3.0 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain SprA-related PF12118.8 KOH00983.1 - 0.61 9.2 5.6 5.9 5.9 0.1 2.2 2 0 0 2 2 2 0 SprA-related family efThoc1 PF11957.8 KOH00984.1 - 3e-115 385.7 30.2 4.2e-115 385.2 30.2 1.1 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor ubiquitin PF00240.23 KOH00985.1 - 2.1e-17 62.6 0.3 2.7e-17 62.3 0.3 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KOH00985.1 - 6.4e-09 35.5 0.1 8.2e-09 35.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 KOH00985.1 - 0.025 14.5 0.0 0.028 14.3 0.0 1.2 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 KOH00985.1 - 0.064 13.7 0.0 0.067 13.6 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-like domain MTS PF05175.14 KOH00986.1 - 1.3e-09 37.9 0.1 1.8e-08 34.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.6 KOH00986.1 - 6.3e-05 22.8 0.0 8.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOH00986.1 - 0.00049 19.6 0.0 0.00096 18.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PRMT5 PF05185.16 KOH00986.1 - 0.01 15.7 0.0 0.02 14.7 0.0 1.4 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase Methyltransf_23 PF13489.6 KOH00986.1 - 0.016 15.0 0.0 0.27 11.1 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain N6-adenineMlase PF10237.9 KOH00986.1 - 0.06 13.2 0.0 0.15 11.9 0.0 1.6 2 0 0 2 2 2 0 Probable N6-adenine methyltransferase UPF0020 PF01170.18 KOH00986.1 - 0.081 12.6 0.0 1.6 8.4 0.0 2.1 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Methyltransf_16 PF10294.9 KOH00986.1 - 0.088 12.5 0.0 3.5 7.3 0.0 2.2 2 0 0 2 2 2 0 Lysine methyltransferase PanZ PF12568.8 KOH00986.1 - 0.09 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Met_10 PF02475.16 KOH00986.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Dopey_N PF04118.14 KOH00987.1 - 3.6e-114 381.0 5.8 1.8e-113 378.7 0.5 3.3 3 0 0 3 3 3 2 Dopey, N-terminal WD40 PF00400.32 KOH00988.1 - 1.6e-17 63.6 12.2 0.0038 18.0 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat zf-RING_2 PF13639.6 KOH00989.1 - 6.2e-10 39.2 5.9 6.2e-08 32.8 1.6 2.3 2 0 0 2 2 2 2 Ring finger domain Prok-RING_4 PF14447.6 KOH00989.1 - 6.9e-07 29.0 2.1 8.5e-07 28.7 0.6 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 KOH00989.1 - 1.1e-06 28.8 0.8 1.1e-06 28.8 0.8 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KOH00989.1 - 5.3e-06 26.4 5.1 9.3e-05 22.4 1.0 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOH00989.1 - 9.8e-06 25.3 4.7 2.5e-05 24.0 1.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOH00989.1 - 5.2e-05 23.0 3.5 8.3e-05 22.4 0.9 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOH00989.1 - 0.00019 21.3 3.9 0.0036 17.2 0.4 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KOH00989.1 - 0.0002 21.4 1.1 0.00056 20.0 1.1 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Rtf2 PF04641.12 KOH00989.1 - 0.00072 19.0 0.0 0.00072 19.0 0.0 3.6 2 2 1 3 3 2 2 Rtf2 RING-finger zf-C3HC4 PF00097.25 KOH00989.1 - 0.0019 18.0 5.7 0.0061 16.4 1.0 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOH00989.1 - 0.012 15.3 2.6 1.5 8.7 0.1 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-ANAPC11 PF12861.7 KOH00989.1 - 0.028 14.5 0.3 0.067 13.3 0.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 KOH00989.1 - 0.087 13.0 5.1 0.059 13.5 1.0 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 FANCL_C PF11793.8 KOH00989.1 - 1.2 9.4 4.7 48 4.2 1.8 3.3 2 1 0 2 2 2 0 FANCL C-terminal domain UPF0547 PF10571.9 KOH00989.1 - 1.3 9.1 3.1 3 8.0 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-RING_4 PF14570.6 KOH00989.1 - 1.5 8.6 3.7 1.9 8.4 0.9 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Asp PF00026.23 KOH00990.1 - 4e-71 240.0 17.2 4e-71 240.0 17.2 2.7 2 1 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOH00990.1 - 8.1e-11 42.5 3.3 8.1e-11 42.5 3.3 2.6 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal BAP PF06639.11 KOH00990.1 - 0.11 12.8 0.1 0.48 10.8 0.1 2.1 1 0 0 1 1 1 0 Basal layer antifungal peptide (BAP) TAXi_C PF14541.6 KOH00990.1 - 0.12 12.2 0.5 5.6 6.7 0.0 2.6 3 0 0 3 3 3 0 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 KOH00990.1 - 0.14 12.8 1.3 42 4.9 0.1 3.7 3 0 0 3 3 3 0 Aspartyl protease TFIID_20kDa PF03847.13 KOH00991.1 - 3.8e-33 113.8 6.3 4.5e-33 113.6 0.4 2.5 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A Histone PF00125.24 KOH00991.1 - 0.011 16.1 0.0 0.011 16.1 0.0 4.3 3 2 0 3 3 3 0 Core histone H2A/H2B/H3/H4 YtxH PF12732.7 KOH00991.1 - 1 10.0 4.4 1.5 9.4 1.5 2.8 1 1 1 2 2 2 0 YtxH-like protein zf-C2H2 PF00096.26 KOH00992.1 - 7.6e-11 41.9 10.4 0.0012 19.1 1.0 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOH00992.1 - 0.00013 22.5 9.3 0.53 11.3 0.4 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOH00992.1 - 0.00048 20.4 11.1 0.022 15.2 0.1 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KOH00992.1 - 0.007 16.6 6.5 9 6.7 1.1 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KOH00992.1 - 0.017 15.1 2.6 1.8 8.7 0.2 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf_ZIC PF18366.1 KOH00992.1 - 0.072 13.2 2.0 31 4.8 0.0 3.3 2 1 1 3 3 3 0 Zic proteins zinc finger domain zf-C2H2_8 PF15909.5 KOH00992.1 - 0.082 13.2 1.2 0.8 10.0 0.4 2.3 1 1 1 2 2 2 0 C2H2-type zinc ribbon AT_hook PF02178.19 KOH00992.1 - 0.15 12.0 5.7 0.53 10.3 5.7 2.0 1 0 0 1 1 1 0 AT hook motif Choline_kinase PF01633.20 KOH00993.1 - 1.5e-59 201.1 1.0 2.2e-59 200.6 1.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 KOH00993.1 - 7.7e-12 44.7 0.1 1.6e-11 43.7 0.1 1.6 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 KOH00993.1 - 2.5e-10 40.7 0.3 4.2e-10 39.9 0.3 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 KOH00993.1 - 3.1e-06 26.7 1.3 4.5e-06 26.2 1.3 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 KOH00993.1 - 0.0006 18.8 0.4 0.00099 18.1 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) P22_Tail-4 PF11650.8 KOH00993.1 - 0.12 12.3 0.4 0.24 11.3 0.4 1.4 1 0 0 1 1 1 0 P22 tail accessory factor 2-oxoacid_dh PF00198.23 KOH00994.1 - 5.7e-81 271.4 0.0 7.8e-81 270.9 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KOH00994.1 - 1.4e-15 56.9 0.4 2.5e-15 56.1 0.4 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 KOH00994.1 - 0.00034 20.4 0.0 0.019 14.8 0.0 2.5 1 1 1 2 2 2 1 Biotin-lipoyl like GCV_H PF01597.19 KOH00994.1 - 0.00039 20.3 0.4 0.0019 18.1 0.1 2.2 1 1 1 2 2 2 1 Glycine cleavage H-protein HlyD_3 PF13437.6 KOH00994.1 - 0.0016 19.1 0.1 0.014 16.1 0.1 2.4 1 1 1 2 2 2 1 HlyD family secretion protein RnfC_N PF13375.6 KOH00994.1 - 0.02 14.9 0.0 0.086 12.8 0.0 2.0 1 1 1 2 2 2 0 RnfC Barrel sandwich hybrid domain CABS1 PF15367.6 KOH00994.1 - 0.027 13.6 0.7 0.027 13.6 0.7 2.1 1 1 1 2 2 2 0 Calcium-binding and spermatid-specific protein 1 HlyD_D23 PF16576.5 KOH00994.1 - 0.084 12.1 0.0 0.29 10.3 0.0 1.8 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion CDC27 PF09507.10 KOH00994.1 - 0.66 9.3 13.4 0.94 8.8 13.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 zf-CCCH PF00642.24 KOH00995.1 - 1.8e-17 62.7 16.0 1e-08 34.8 6.3 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOH00995.1 - 5.5e-05 23.1 19.6 0.011 15.8 3.7 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 KOH00995.1 - 0.021 14.6 15.3 0.22 11.4 1.2 2.3 2 0 0 2 2 2 0 CCCH-type zinc finger Torus PF16131.5 KOH00995.1 - 0.026 15.2 10.5 0.83 10.4 2.6 2.5 1 1 1 2 2 2 0 Torus domain Defensin_int PF17858.1 KOH00995.1 - 0.21 11.6 0.7 0.5 10.4 0.7 1.6 1 0 0 1 1 1 0 Platypus intermediate defensin-like peptide RWD PF05773.22 KOH00996.1 - 5.2e-25 88.0 9.0 1.1e-24 86.9 9.0 1.6 1 1 0 1 1 1 1 RWD domain CENP-B_dimeris PF09026.10 KOH00996.1 - 0.026 14.9 6.5 0.073 13.5 6.5 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4611 PF15387.6 KOH00996.1 - 0.51 10.6 9.2 3 8.1 6.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Sporozoite_P67 PF05642.11 KOH00996.1 - 0.57 8.2 3.7 0.77 7.8 3.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FAM176 PF14851.6 KOH00996.1 - 0.83 9.3 9.1 0.29 10.8 2.5 2.2 2 0 0 2 2 2 0 FAM176 family Cytomega_UL84 PF06284.11 KOH00996.1 - 3.7 5.9 4.2 5.7 5.3 4.2 1.4 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein NOA36 PF06524.12 KOH00996.1 - 9 5.5 11.3 2 7.7 7.8 1.6 2 0 0 2 2 2 0 NOA36 protein ENTH PF01417.20 KOH00997.1 - 2e-31 108.6 0.1 3.5e-31 107.8 0.1 1.4 1 0 0 1 1 1 1 ENTH domain SUIM_assoc PF16619.5 KOH00997.1 - 1.9 8.6 8.9 0.25 11.5 4.6 1.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 VPS38 PF17649.1 KOH00997.1 - 1.9 7.3 8.2 0.11 11.4 2.8 1.5 2 0 0 2 2 2 0 Vacuolar protein sorting 38 Pro_isomerase PF00160.21 KOH00998.1 - 5.1e-46 156.8 0.1 5.7e-46 156.7 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 KOH00998.1 - 0.099 12.7 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin domain RNA_polI_A14 PF08203.11 KOH00999.1 - 8.1e-28 97.0 0.4 1.7e-27 95.9 0.1 1.7 2 0 0 2 2 2 1 Yeast RNA polymerase I subunit RPA14 TMEM215 PF15746.5 KOH00999.1 - 0.015 14.8 0.0 0.018 14.5 0.0 1.1 1 0 0 1 1 1 0 TMEM215 family Semialdhyde_dhC PF02774.18 KOH01000.1 - 3.3e-44 151.2 0.0 4.7e-44 150.7 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 KOH01000.1 - 2.7e-32 111.7 0.0 4.5e-32 111.0 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 KOH01000.1 - 0.029 15.1 0.0 0.075 13.8 0.0 1.7 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Sacchrp_dh_NADP PF03435.18 KOH01000.1 - 0.045 14.0 0.0 0.088 13.1 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain SAC3_GANP PF03399.16 KOH01001.1 - 1.8e-100 336.1 0.8 1.8e-100 336.1 0.8 2.5 2 0 0 2 2 2 1 SAC3/GANP family SAC3 PF12209.8 KOH01001.1 - 2.6e-22 78.8 4.0 2.6e-22 78.8 4.0 2.4 2 0 0 2 2 2 1 Leucine permease transcriptional regulator helical domain CaM_binding PF07839.11 KOH01001.1 - 9 7.1 16.3 0.19 12.4 7.4 2.9 2 0 0 2 2 2 0 Plant calmodulin-binding domain AA_permease PF00324.21 KOH01002.1 - 7.3e-73 245.8 44.5 8.2e-72 242.3 44.5 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOH01002.1 - 9.7e-28 97.1 40.6 7.6e-27 94.2 40.6 1.9 1 1 0 1 1 1 1 Amino acid permease NYD-SP28_assoc PF14775.6 KOH01002.1 - 0.15 12.2 0.4 0.56 10.4 0.0 2.1 2 0 0 2 2 2 0 Sperm tail C-terminal domain TPR_19 PF14559.6 KOH01003.1 - 2e-06 28.2 3.3 0.0089 16.5 0.7 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOH01003.1 - 4.9e-05 23.5 2.7 0.0063 16.7 0.4 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 KOH01003.1 - 0.00026 21.5 1.5 0.62 11.0 0.1 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOH01003.1 - 0.00026 20.8 7.9 0.75 10.1 0.0 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOH01003.1 - 0.0022 17.6 2.4 1.1 9.0 0.0 3.6 3 0 0 3 3 3 1 TPR repeat TPR_MalT PF17874.1 KOH01003.1 - 0.036 13.4 1.0 2.2 7.6 0.0 2.2 2 0 0 2 2 2 0 MalT-like TPR region YfdX PF10938.8 KOH01003.1 - 0.06 13.3 3.1 0.61 10.0 3.1 2.4 1 1 0 1 1 1 0 YfdX protein TPR_8 PF13181.6 KOH01003.1 - 0.091 13.0 6.8 2.3 8.6 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat RcsC PF09456.10 KOH01003.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 RcsC Alpha-Beta-Loop (ABL) TPR_17 PF13431.6 KOH01003.1 - 0.11 13.0 0.1 6.3 7.4 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat SLATT_4 PF18186.1 KOH01003.1 - 0.13 11.9 0.0 0.3 10.7 0.0 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 TPR_21 PF09976.9 KOH01003.1 - 0.18 11.5 2.4 8.7 6.0 1.5 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain TPR_15 PF13429.6 KOH01003.1 - 0.18 11.0 0.7 6.6 5.8 0.2 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOH01003.1 - 0.22 11.4 10.1 0.56 10.1 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat SH3_1 PF00018.28 KOH01004.1 - 3.1e-12 45.9 0.0 3.1e-12 45.9 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 KOH01004.1 - 2.8e-11 43.1 0.0 6.7e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOH01004.1 - 1.7e-05 24.4 0.0 4e-05 23.2 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain DUF5599 PF18141.1 KOH01004.1 - 0.045 14.0 0.0 0.093 13.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5599) Cwf_Cwc_15 PF04889.12 KOH01004.1 - 2.3 7.9 21.8 0.12 12.0 9.7 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Cwf_Cwc_15 PF04889.12 KOH01005.1 - 8.8e-16 58.4 36.0 3.7e-08 33.4 1.1 3.0 1 1 2 3 3 3 3 Cwf15/Cwc15 cell cycle control protein PA26 PF04636.13 KOH01005.1 - 3.7 6.4 7.7 4.1 6.2 7.7 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Sec1 PF00995.23 KOH01006.1 - 6.7e-92 309.6 4.1 7.9e-92 309.3 4.1 1.1 1 0 0 1 1 1 1 Sec1 family WD40 PF00400.32 KOH01007.1 - 2.7e-06 28.0 4.3 0.33 11.9 0.8 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat CPSF_A PF03178.15 KOH01007.1 - 0.00032 20.1 1.5 0.011 15.1 0.1 3.0 2 1 1 3 3 3 1 CPSF A subunit region Sec5 PF15469.6 KOH01008.1 - 4.7e-51 173.3 16.6 4.7e-51 173.3 16.6 2.4 2 0 0 2 2 2 1 Exocyst complex component Sec5 Vps51 PF08700.11 KOH01008.1 - 0.00033 20.7 4.3 0.00033 20.7 4.3 3.0 2 1 1 3 3 3 1 Vps51/Vps67 DUF2982 PF11201.8 KOH01008.1 - 0.0066 16.0 0.6 0.022 14.3 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2982) COG2 PF06148.11 KOH01008.1 - 0.16 12.1 5.8 0.57 10.3 5.8 2.0 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 MtrG PF04210.13 KOH01008.1 - 0.28 11.1 1.9 1.6 8.6 0.0 2.9 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G TFIID_30kDa PF03540.13 KOH01009.1 - 1.9e-25 88.5 0.1 2.9e-25 87.9 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.13 KOH01009.1 - 0.041 13.9 0.2 0.33 11.0 0.0 2.4 3 0 0 3 3 3 0 Bromodomain associated GCP_N_terminal PF17681.1 KOH01009.1 - 0.088 12.4 0.1 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 Gamma tubulin complex component N-terminal CDC37_N PF03234.14 KOH01010.1 - 4.5e-43 147.2 8.7 4.5e-43 147.2 8.7 3.7 3 2 1 4 4 4 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 KOH01010.1 - 3.6e-39 133.3 5.2 1.3e-38 131.6 5.2 2.0 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 KOH01010.1 - 1.7e-25 89.1 7.1 1.7e-25 89.1 7.1 2.9 2 0 0 2 2 2 1 Cdc37 C terminal domain BST2 PF16716.5 KOH01010.1 - 0.044 14.4 1.9 0.13 12.9 0.1 2.7 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Stb3 PF10330.9 KOH01011.1 - 1.6e-31 108.2 0.0 3.5e-31 107.1 0.0 1.5 1 0 0 1 1 1 1 Putative Sin3 binding protein Sec7 PF01369.20 KOH01013.1 - 2e-71 239.5 0.2 6.8e-71 237.7 0.2 2.0 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 KOH01013.1 - 4.9e-41 140.3 0.9 4.9e-41 140.3 0.9 3.7 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 KOH01013.1 - 3.3e-26 90.9 14.7 3.5e-26 90.9 0.4 6.0 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) DCB PF16213.5 KOH01013.1 - 5.6e-18 65.2 4.1 5.5e-17 62.0 1.0 3.6 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 HSP20 PF00011.21 KOH01014.1 - 5.6e-12 45.7 0.1 1.3e-11 44.5 0.1 1.6 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KOH01014.1 - 5e-05 22.8 0.0 9.3e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 HSP20-like domain found in ArsA GTP_EFTU PF00009.27 KOH01015.1 - 8.7e-45 152.7 1.0 2.5e-44 151.2 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KOH01015.1 - 6e-36 123.2 4.2 6.1e-36 123.1 1.1 2.6 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KOH01015.1 - 4.3e-08 33.4 0.5 4.3e-08 33.4 0.5 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOH01015.1 - 0.0031 17.6 1.6 0.013 15.6 0.1 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase TFIIA PF03153.13 KOH01015.1 - 0.027 14.5 24.6 0.041 13.9 24.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_U32_C PF16325.5 KOH01015.1 - 0.088 13.1 0.2 0.34 11.2 0.1 2.1 2 0 0 2 2 2 0 Peptidase family U32 C-terminal domain IPK PF03770.16 KOH01016.1 - 4.3e-55 186.6 0.3 5.3e-55 186.4 0.3 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase HMG_box PF00505.19 KOH01017.1 - 6.3e-12 45.7 4.2 6.3e-12 45.7 4.2 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOH01017.1 - 7.2e-09 36.1 2.9 7.2e-09 36.1 2.9 1.7 2 0 0 2 2 2 1 HMG-box domain Transketolase_N PF00456.21 KOH01017.1 - 0.0064 15.5 0.7 0.0086 15.1 0.7 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain MRP-S28 PF10213.9 KOH01018.1 - 1.7e-51 173.9 5.7 3e-51 173.1 5.7 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Ada3 PF10198.9 KOH01019.1 - 5.5e-45 152.8 4.3 5.5e-45 152.8 4.3 2.5 2 1 0 2 2 2 1 Histone acetyltransferases subunit 3 UQ_con PF00179.26 KOH01020.1 - 7.7e-45 152.0 0.0 1e-44 151.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 KOH01020.1 - 2.2e-30 104.2 1.3 3.6e-30 103.6 1.3 1.3 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain GGA_N-GAT PF18308.1 KOH01020.1 - 0.00057 19.4 3.3 0.081 12.6 0.2 2.3 2 0 0 2 2 2 2 GGA N-GAT domain RGS12_usC PF16612.5 KOH01020.1 - 0.0098 16.3 0.0 0.017 15.6 0.0 1.4 1 0 0 1 1 1 1 C-terminal unstructured region of RGS12 Calsarcin PF05556.11 KOH01020.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-binding protein (Calsarcin) DUF1421 PF07223.11 KOH01020.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 UBA-like domain (DUF1421) CybS PF05328.12 KOH01021.1 - 9e-50 167.8 0.0 1.1e-49 167.5 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit BAH PF01426.18 KOH01022.1 - 0.026 14.4 0.7 0.039 13.8 0.6 1.5 1 1 0 1 1 1 0 BAH domain PCI PF01399.27 KOH01022.1 - 0.03 14.9 0.6 0.047 14.2 0.6 1.4 1 0 0 1 1 1 0 PCI domain PXA PF02194.15 KOH01023.1 - 1.8e-12 47.6 0.6 8.3e-12 45.4 0.6 2.0 1 1 0 1 1 1 1 PXA domain Nipped-B_C PF12830.7 KOH01024.1 - 2.2e-29 102.7 4.2 2.9e-28 99.1 0.9 4.0 3 0 0 3 3 3 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 KOH01024.1 - 1.5e-15 57.2 2.8 2.5e-14 53.2 1.2 2.9 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.22 KOH01024.1 - 0.0019 18.3 3.4 28 5.3 0.0 5.4 5 0 0 5 5 5 0 HEAT repeat DEAD PF00270.29 KOH01024.1 - 0.12 12.2 0.3 0.53 10.0 0.2 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase Methyltransf_31 PF13847.6 KOH01024.1 - 0.18 11.6 0.9 0.69 9.7 0.2 2.4 2 0 0 2 2 2 0 Methyltransferase domain Phage_int_SAM_5 PF13102.6 KOH01024.1 - 0.56 10.6 7.7 0.32 11.4 1.2 3.9 2 1 2 4 4 4 0 Phage integrase SAM-like domain Csm1_N PF18504.1 KOH01024.1 - 4.8 7.6 6.1 1.8 9.0 0.5 3.3 3 0 0 3 3 3 0 Csm1 N-terminal domain SAS4 PF15460.6 KOH01025.1 - 5.1e-30 103.5 6.4 2.9e-29 101.1 6.4 2.4 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 Metallophos PF00149.28 KOH01026.1 - 1.1e-11 45.6 0.3 2e-11 44.8 0.3 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Orf78 PF06024.12 KOH01026.1 - 0.021 15.1 0.3 1.1 9.6 0.1 2.3 2 0 0 2 2 2 0 Orf78 (ac78) Phosducin PF02114.16 KOH01027.1 - 3e-08 33.0 0.5 3.5e-08 32.7 0.5 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 KOH01027.1 - 2.2e-05 24.4 0.2 4.5e-05 23.4 0.0 1.6 2 0 0 2 2 2 1 Thioredoxin Sigma70_ner PF04546.13 KOH01027.1 - 0.03 14.2 4.0 0.041 13.8 4.0 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region WD-3 PF09765.9 KOH01027.1 - 0.061 12.7 0.9 0.081 12.2 0.9 1.2 1 0 0 1 1 1 0 WD-repeat region FANCL_C PF11793.8 KOH01027.1 - 0.093 12.9 0.1 1.5 9.1 0.0 2.3 1 1 1 2 2 2 0 FANCL C-terminal domain VasL PF12486.8 KOH01028.1 - 0.013 15.4 0.2 0.025 14.4 0.2 1.6 1 0 0 1 1 1 0 Type VI secretion system, EvfB, or VasL HALZ PF02183.18 KOH01028.1 - 0.062 13.5 2.4 0.22 11.7 2.4 2.0 1 1 0 1 1 1 0 Homeobox associated leucine zipper PRELI PF04707.14 KOH01029.1 - 1.9e-56 190.2 0.4 2.3e-56 189.9 0.4 1.0 1 0 0 1 1 1 1 PRELI-like family Cwf_Cwc_15 PF04889.12 KOH01030.1 - 1.7 8.3 28.2 0.016 15.0 14.5 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Cpn60_TCP1 PF00118.24 KOH01031.1 - 2.1e-158 528.0 1.0 2.4e-158 527.8 1.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sec1 PF00995.23 KOH01032.1 - 1.9e-120 403.9 6.8 2.7e-120 403.3 6.8 1.2 1 0 0 1 1 1 1 Sec1 family TIP49 PF06068.13 KOH01033.1 - 6.2e-169 561.7 0.6 7.7e-169 561.4 0.6 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 KOH01033.1 - 6.4e-24 83.9 0.1 1.8e-23 82.4 0.1 1.8 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 KOH01033.1 - 2.3e-08 34.5 0.3 8.5e-05 23.0 0.0 2.7 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOH01033.1 - 2.8e-07 30.4 0.2 9.7e-05 22.2 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 KOH01033.1 - 0.0012 19.1 0.0 0.0025 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOH01033.1 - 0.0037 17.6 0.8 3.7 7.9 0.2 2.5 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.15 KOH01033.1 - 0.016 14.6 0.0 0.031 13.6 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_5 PF07728.14 KOH01033.1 - 0.023 14.7 0.2 0.81 9.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KOH01033.1 - 0.025 14.0 0.1 4.1 6.7 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 KOH01033.1 - 0.038 14.4 0.1 0.15 12.5 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain CPT PF07931.12 KOH01033.1 - 0.054 13.3 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 KOH01033.1 - 0.073 12.3 0.1 0.18 11.1 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin Sigma54_activat PF00158.26 KOH01033.1 - 0.12 12.1 0.0 15 5.3 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain SIR2 PF02146.17 KOH01034.1 - 1.4e-24 87.0 0.0 2.8e-24 86.0 0.0 1.5 1 1 0 1 1 1 1 Sir2 family DEAD PF00270.29 KOH01035.1 - 2.4e-43 147.9 0.4 4e-41 140.7 0.0 2.5 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 KOH01035.1 - 1.8e-26 92.6 0.6 9e-26 90.4 0.1 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOH01035.1 - 3.9e-06 27.0 2.2 9.4e-06 25.7 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOH01035.1 - 0.0056 15.9 0.1 0.011 14.9 0.1 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase MazG PF03819.17 KOH01035.1 - 0.016 15.3 0.3 0.055 13.6 0.3 1.9 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain AAA_30 PF13604.6 KOH01035.1 - 0.019 14.7 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF2201 PF09967.9 KOH01035.1 - 0.12 12.5 0.0 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 VWA-like domain (DUF2201) PNPase PF03726.14 KOH01035.1 - 0.41 11.2 2.7 0.59 10.7 0.1 2.4 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain SET PF00856.28 KOH01036.1 - 8.5 6.7 8.9 22 5.4 8.9 1.8 1 1 0 1 1 1 0 SET domain CoaE PF01121.20 KOH01037.1 - 6.7e-67 224.6 0.0 8.4e-67 224.3 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase SKI PF01202.22 KOH01037.1 - 0.001 19.2 0.1 0.019 15.1 0.0 2.3 2 0 0 2 2 2 1 Shikimate kinase AAA_18 PF13238.6 KOH01037.1 - 0.0011 19.6 0.2 0.006 17.1 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOH01037.1 - 0.0024 18.0 0.0 0.013 15.7 0.0 2.0 1 1 1 2 2 2 1 AAA domain PRK PF00485.18 KOH01037.1 - 0.0058 16.4 0.1 0.033 13.9 0.0 2.0 2 1 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.6 KOH01037.1 - 0.0069 16.8 0.0 0.025 15.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 KOH01037.1 - 0.0076 16.5 0.0 0.023 15.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain Cytidylate_kin2 PF13189.6 KOH01037.1 - 0.02 15.0 0.0 0.15 12.1 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase-like family Abi_2 PF07751.11 KOH01037.1 - 0.036 14.3 0.0 0.056 13.7 0.0 1.3 1 0 0 1 1 1 0 Abi-like protein dNK PF01712.19 KOH01037.1 - 0.081 12.8 0.2 0.78 9.6 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase tRNA_lig_kinase PF08303.11 KOH01037.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.7 2 0 0 2 2 2 0 tRNA ligase kinase domain Zeta_toxin PF06414.12 KOH01037.1 - 0.12 11.7 0.2 11 5.2 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin ApbA_C PF08546.11 KOH01038.1 - 2.8e-17 63.1 0.0 4.5e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal SET PF00856.28 KOH01039.1 - 7.3e-07 29.7 0.0 1.9e-06 28.4 0.0 1.7 1 1 0 1 1 1 1 SET domain FHA PF00498.26 KOH01040.1 - 5.2e-19 68.4 0.3 4.7e-18 65.3 0.2 2.7 1 1 1 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 KOH01040.1 - 4.4e-05 23.7 0.5 0.00013 22.3 0.0 1.9 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Ribosomal_L2_C PF03947.18 KOH01040.1 - 0.096 12.9 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Ribosomal Proteins L2, C-terminal domain DUF4407 PF14362.6 KOH01040.1 - 1.5 8.1 8.8 3.2 7.0 8.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 KOH01040.1 - 2.6 7.5 12.8 6.9 6.1 12.8 1.7 1 0 0 1 1 1 0 Exonuclease VII, large subunit DASH_Spc19 PF08287.11 KOH01041.1 - 2.7e-37 128.1 10.3 3.1e-37 127.9 10.3 1.0 1 0 0 1 1 1 1 Spc19 EzrA PF06160.12 KOH01041.1 - 0.05 11.8 8.6 0.035 12.3 6.1 1.8 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA FapA PF03961.13 KOH01041.1 - 0.35 9.4 5.8 0.4 9.2 4.9 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A BLOC1_2 PF10046.9 KOH01041.1 - 0.55 10.6 11.2 6.3 7.2 1.5 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2205 PF10224.9 KOH01041.1 - 0.74 9.8 12.1 1.6 8.8 0.1 3.3 3 1 0 3 3 3 0 Short coiled-coil protein LapA_dom PF06305.11 KOH01041.1 - 1.4 8.8 4.8 9.1 6.2 1.5 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain FlaC_arch PF05377.11 KOH01041.1 - 2.5 8.6 10.2 4.5 7.7 0.1 3.5 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DASH_Dad2 PF08654.10 KOH01041.1 - 8.5 6.9 14.0 20 5.7 4.9 3.3 3 0 0 3 3 3 0 DASH complex subunit Dad2 Rogdi_lz PF10259.9 KOH01042.1 - 1.1e-61 208.7 3.0 1.3e-61 208.5 3.0 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Coq4 PF05019.13 KOH01043.1 - 1.6e-93 312.1 0.0 2e-93 311.8 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 GreA_GreB_N PF03449.15 KOH01043.1 - 0.29 11.3 4.9 0.11 12.7 1.8 1.9 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal Cation_efflux PF01545.21 KOH01044.1 - 2.8e-44 151.3 13.0 2.8e-44 151.3 13.0 2.8 3 1 0 3 3 3 1 Cation efflux family EST1_DNA_bind PF10373.9 KOH01045.1 - 3.5e-45 154.7 1.7 6.7e-45 153.8 0.1 2.2 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 KOH01045.1 - 2.5e-18 67.0 0.8 2.5e-18 67.0 0.8 2.6 3 0 0 3 3 3 1 Telomerase activating protein Est1 Pallilysin PF18663.1 KOH01045.1 - 0.14 12.2 3.9 0.6 10.1 3.9 2.1 1 0 0 1 1 1 0 Pallilysin beta barrel domain Zn_clus PF00172.18 KOH01046.1 - 9.6e-09 35.2 8.7 1.7e-08 34.4 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PIP5K PF01504.18 KOH01047.1 - 4e-94 314.9 3.1 4e-94 314.9 3.1 2.4 2 1 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Amelin PF05111.12 KOH01047.1 - 0.013 14.7 5.4 0.026 13.7 5.4 1.4 1 0 0 1 1 1 0 Ameloblastin precursor (Amelin) W2 PF02020.18 KOH01048.1 - 3e-15 56.1 1.9 8.8e-15 54.6 1.9 1.8 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 KOH01048.1 - 5.7e-12 44.9 16.6 4e-05 23.2 4.7 3.9 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 KOH01048.1 - 2.4e-09 37.1 0.0 5.1e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyl transferase DUF4954 PF16314.5 KOH01048.1 - 1.4e-07 30.0 0.5 2.9e-07 29.0 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 KOH01048.1 - 0.0032 16.5 2.3 0.01 14.8 2.3 1.8 1 1 0 1 1 1 1 L-fucokinase NTP_transf_3 PF12804.7 KOH01048.1 - 0.01 16.2 0.0 0.019 15.3 0.0 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain FAS_N PF17828.1 KOH01048.1 - 0.07 13.1 0.1 0.21 11.6 0.1 1.8 1 0 0 1 1 1 0 N-terminal domain in fatty acid synthase subunit beta CTP_transf_3 PF02348.19 KOH01048.1 - 0.091 12.7 0.4 1.3 8.9 0.0 2.6 3 0 0 3 3 3 0 Cytidylyltransferase Nudix_N PF12535.8 KOH01048.1 - 0.16 11.6 0.0 0.47 10.1 0.0 1.8 1 0 0 1 1 1 0 Hydrolase of X-linked nucleoside diphosphate N terminal YfdX PF10938.8 KOH01048.1 - 0.21 11.5 0.4 0.38 10.7 0.4 1.3 1 0 0 1 1 1 0 YfdX protein Hexapep_2 PF14602.6 KOH01048.1 - 0.69 9.7 17.8 3.9 7.3 1.0 4.1 1 1 1 2 2 2 0 Hexapeptide repeat of succinyl-transferase Cpn60_TCP1 PF00118.24 KOH01049.1 - 7.7e-152 506.3 12.6 8.8e-152 506.2 12.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Fungal_trans_2 PF11951.8 KOH01050.1 - 1.3e-11 43.9 0.2 1.3e-11 43.9 0.2 2.8 2 1 1 3 3 3 2 Fungal specific transcription factor domain Zn_clus PF00172.18 KOH01050.1 - 4.7e-08 33.0 10.5 7.4e-08 32.4 10.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aha1_N PF09229.11 KOH01051.1 - 3.9e-36 124.3 0.5 1.9e-35 122.1 0.1 2.2 2 1 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 KOH01051.1 - 1.2e-11 44.9 0.2 1.8e-11 44.4 0.2 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein PcfK PF14058.6 KOH01051.1 - 0.034 14.4 1.2 0.044 14.1 0.0 1.8 2 0 0 2 2 2 0 PcfK-like protein DUF515 PF04415.12 KOH01051.1 - 0.79 8.0 4.7 1.2 7.4 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF3446 PF11928.8 KOH01051.1 - 1.9 8.9 7.8 3.6 8.0 7.8 1.5 1 0 0 1 1 1 0 Early growth response N-terminal domain zf-C2H2 PF00096.26 KOH01052.1 - 9.2e-11 41.6 10.6 2.9e-05 24.3 2.3 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOH01052.1 - 9.6e-06 26.0 9.7 0.013 16.3 2.2 3.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOH01052.1 - 1.1e-05 25.7 10.6 5.3e-05 23.5 6.8 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-met PF12874.7 KOH01052.1 - 0.00042 20.6 7.6 0.017 15.5 0.7 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf_C2H2_ZHX PF18387.1 KOH01052.1 - 0.078 12.6 3.4 0.7 9.6 0.1 2.7 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_11 PF16622.5 KOH01052.1 - 0.3 10.9 5.1 2.9 7.7 0.3 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 KOH01052.1 - 0.43 10.9 4.3 0.21 11.9 0.7 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding NUP50 PF08911.11 KOH01052.1 - 1.9 9.2 5.3 1.2 9.9 1.9 2.4 1 1 1 2 2 2 0 NUP50 (Nucleoporin 50 kDa) Septin PF00735.18 KOH01053.1 - 5.9e-66 222.6 1.3 1.3e-65 221.4 1.3 1.5 1 1 0 1 1 1 1 Septin G-alpha PF00503.20 KOH01053.1 - 0.0065 15.7 1.4 0.061 12.5 0.2 2.3 1 1 1 2 2 2 1 G-protein alpha subunit AAA_24 PF13479.6 KOH01053.1 - 0.042 13.6 0.0 0.1 12.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain CENP-R PF06729.12 KOH01053.1 - 0.069 13.1 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 Kinetochore component, CENP-R Dynamin_N PF00350.23 KOH01053.1 - 0.17 12.0 2.4 0.4 10.7 0.1 2.5 3 0 0 3 3 3 0 Dynamin family F-box PF00646.33 KOH01054.1 - 1.8e-05 24.5 0.1 5e-05 23.1 0.1 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOH01054.1 - 4.4e-05 23.3 0.0 0.00014 21.6 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 KOH01054.1 - 0.0073 16.2 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 F-box PRKCSH-like PF12999.7 KOH01055.1 - 4.5e-30 104.7 11.2 2.6e-29 102.2 11.2 2.3 1 1 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 KOH01055.1 - 1.4e-20 73.6 2.0 4.9e-19 68.5 2.0 2.9 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 KOH01055.1 - 7.1e-07 30.1 0.6 2.7e-06 28.3 0.6 2.1 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein DUF3502 PF12010.8 KOH01055.1 - 0.0075 16.9 0.9 0.026 15.2 0.3 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF3502) Ldl_recept_a PF00057.18 KOH01055.1 - 0.48 10.7 12.9 2.1 8.6 2.3 2.8 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A ABC2_membrane_3 PF12698.7 KOH01055.1 - 3.1 6.8 4.8 5.9 5.9 4.8 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein Svf1 PF08622.10 KOH01056.1 - 4.6e-40 137.4 0.2 8.3e-40 136.5 0.2 1.4 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Svf1_C PF17187.4 KOH01056.1 - 6.4e-39 133.4 1.2 3.2e-38 131.1 1.2 2.1 1 1 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Lactococcin PF04369.13 KOH01056.1 - 0.65 10.2 3.4 3.1 8.0 0.1 2.5 2 0 0 2 2 2 0 Lactococcin-like family CRF1 PF10380.9 KOH01057.1 - 1.8e-19 70.2 1.2 1.8e-19 70.2 1.2 2.3 2 0 0 2 2 2 1 Transcription factor CRF1 Histone PF00125.24 KOH01058.1 - 4.3e-19 69.2 3.8 6.1e-19 68.7 3.8 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOH01058.1 - 7.8e-06 26.1 0.1 1.6e-05 25.1 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KOH01058.1 - 0.0016 18.9 0.0 0.0027 18.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CENP-W PF15510.6 KOH01058.1 - 0.025 14.8 0.0 0.037 14.2 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein YscO-like PF16789.5 KOH01058.1 - 0.036 14.1 0.5 0.043 13.8 0.5 1.1 1 0 0 1 1 1 0 YscO-like protein DUF1018 PF06252.12 KOH01058.1 - 0.1 13.6 1.3 0.15 13.1 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) Histone_H2A_C PF16211.5 KOH01059.1 - 5.5e-21 74.0 1.3 8.9e-21 73.3 1.3 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KOH01059.1 - 1.2e-17 64.5 0.0 1.7e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOH01059.1 - 7.4e-06 26.2 0.0 1.2e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone LcrG PF07216.12 KOH01059.1 - 0.053 13.5 0.0 0.081 12.9 0.0 1.4 1 0 0 1 1 1 0 LcrG protein ADK PF00406.22 KOH01060.1 - 4.2e-60 202.2 0.0 5e-60 202.0 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOH01060.1 - 9.1e-23 81.2 0.2 2.5e-22 79.8 0.0 1.7 1 1 1 2 2 2 1 AAA domain ADK_lid PF05191.14 KOH01060.1 - 2.1e-16 59.6 0.0 4.6e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 KOH01060.1 - 1.1e-07 32.1 0.0 3.6e-07 30.5 0.0 1.7 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 KOH01060.1 - 5.7e-06 26.9 0.0 1e-05 26.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 KOH01060.1 - 0.026 14.8 0.0 0.095 13.0 0.0 1.7 1 1 1 2 2 2 0 Hydin Adenylate kinase-like domain Cytidylate_kin PF02224.18 KOH01060.1 - 0.041 13.6 0.0 0.059 13.1 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_22 PF13401.6 KOH01060.1 - 0.091 13.0 0.0 0.23 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KOH01060.1 - 0.16 11.2 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin SIR4_SID PF16991.5 KOH01061.1 - 8.1e-45 152.8 6.7 8.1e-45 152.8 6.7 5.2 7 1 0 7 7 7 1 Sir4 SID domain CFIA_Pcf11 PF11526.8 KOH01062.1 - 4.7e-24 84.7 12.2 4.7e-24 84.7 12.2 2.6 2 0 0 2 2 2 1 Subunit of cleavage factor IA Pcf11 CTD_bind PF04818.13 KOH01062.1 - 0.003 18.4 1.7 0.051 14.4 0.1 3.4 3 0 0 3 3 3 1 RNA polymerase II-binding domain. VHS PF00790.19 KOH01062.1 - 0.01 15.7 3.0 0.021 14.7 0.0 2.8 3 0 0 3 3 3 0 VHS domain zf-C2H2_4 PF13894.6 KOH01062.1 - 0.017 15.9 3.1 1.1 10.3 0.3 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 KOH01062.1 - 0.049 14.1 2.3 8.6 6.9 0.1 2.9 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-H2C2_2 PF13465.6 KOH01062.1 - 0.1 13.1 0.5 6.1 7.4 0.0 2.8 2 0 0 2 2 2 0 Zinc-finger double domain TF_Zn_Ribbon PF08271.12 KOH01062.1 - 0.27 10.8 0.1 0.27 10.8 0.1 2.5 3 0 0 3 3 3 0 TFIIB zinc-binding zf_UBZ PF18439.1 KOH01062.1 - 0.58 9.8 7.9 0.62 9.7 3.1 2.8 2 1 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 KOH01062.1 - 1.2 9.2 7.5 3.4 7.8 0.6 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger MalF_P2 PF14785.6 KOH01063.1 - 0.035 14.1 0.3 0.084 12.9 0.3 1.6 1 0 0 1 1 1 0 Maltose transport system permease protein MalF P2 domain BMFP PF04380.13 KOH01063.1 - 0.038 14.5 1.8 0.093 13.2 0.6 2.2 2 0 0 2 2 2 0 Membrane fusogenic activity Peptidase_C97 PF05903.14 KOH01063.1 - 0.12 12.2 0.1 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 PPPDE putative peptidase domain DUF3767 PF12597.8 KOH01064.1 - 1.1e-35 121.5 0.1 1.1e-35 121.5 0.1 2.0 3 0 0 3 3 3 1 Protein of unknown function (DUF3767) NDUF_B4 PF07225.12 KOH01064.1 - 0.097 12.6 0.9 0.16 11.9 0.2 1.7 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) B12D PF06522.11 KOH01064.1 - 9 6.2 8.1 2 8.3 0.2 2.4 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Aminotran_1_2 PF00155.21 KOH01065.1 - 2.3e-72 244.1 0.2 9.4e-72 242.2 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 KOH01065.1 - 2.2e-08 33.1 0.0 4.1e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KOH01065.1 - 0.00025 20.1 0.0 0.00049 19.2 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KOH01065.1 - 0.00044 19.7 0.8 0.0061 15.9 0.8 2.3 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Reticulon PF02453.17 KOH01066.1 - 1.6e-33 115.9 3.3 2.3e-33 115.4 2.8 1.5 1 1 1 2 2 2 1 Reticulon ATP-synt_E PF05680.12 KOH01067.1 - 0.23 11.8 0.0 0.34 11.3 0.0 1.3 1 0 0 1 1 1 0 ATP synthase E chain Aconitase PF00330.20 KOH01068.1 - 8.3e-112 374.5 0.1 7.8e-111 371.3 0.1 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KOH01068.1 - 3.2e-37 127.8 0.1 7.9e-37 126.5 0.0 1.7 2 0 0 2 2 2 1 Aconitase C-terminal domain Suf PF05843.14 KOH01069.1 - 0.011 15.7 13.3 0.052 13.5 1.2 3.2 2 1 1 3 3 3 0 Suppressor of forked protein (Suf) Flavokinase PF01687.17 KOH01070.1 - 8.7e-27 93.6 0.0 1.2e-26 93.2 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase Ribosomal_L5_C PF00673.21 KOH01071.1 - 7.1e-30 103.0 0.1 6.8e-29 99.9 0.0 2.2 2 0 0 2 2 2 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 KOH01071.1 - 6.8e-12 45.5 0.0 1.3e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L5 Adaptin_N PF01602.20 KOH01072.1 - 7.4e-118 394.4 10.4 1.1e-117 393.7 10.4 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 KOH01072.1 - 1.8e-53 179.9 0.1 6.1e-53 178.2 0.0 2.0 2 0 0 2 2 2 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 KOH01072.1 - 9.8e-53 177.8 2.0 1.3e-52 177.5 0.4 2.1 2 0 0 2 2 2 1 Coatomer beta C-terminal region Cnd1 PF12717.7 KOH01072.1 - 0.00014 22.0 0.1 0.00014 22.0 0.1 4.5 3 1 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOH01072.1 - 0.0015 18.9 4.3 2.1 8.8 0.0 4.7 1 1 4 5 5 5 1 HEAT repeats Vac14_Fab1_bd PF12755.7 KOH01072.1 - 0.011 16.3 0.1 0.061 13.9 0.1 2.3 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region DUF5578 PF17741.1 KOH01072.1 - 0.074 12.5 7.9 3.1 7.2 0.9 3.4 2 2 1 4 4 4 0 Family of unknown function (DUF5578) FANCI_S2 PF14676.6 KOH01072.1 - 0.53 10.6 4.1 1.3 9.3 0.2 3.4 3 1 0 3 3 3 0 FANCI solenoid 2 DUF247 PF03140.15 KOH01074.1 - 0.001 18.4 0.0 0.002 17.4 0.0 1.5 1 0 0 1 1 1 1 Plant protein of unknown function Swi5 PF07061.11 KOH01074.1 - 0.081 13.0 0.5 0.83 9.8 0.0 2.7 2 0 0 2 2 2 0 Swi5 DEAD PF00270.29 KOH01075.1 - 2.2e-45 154.6 0.7 3.8e-44 150.5 0.1 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOH01075.1 - 5.8e-31 107.1 0.2 2.6e-30 105.0 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOH01075.1 - 1.3e-06 28.6 0.7 4.6e-06 26.7 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit CreA PF05981.12 KOH01075.1 - 0.12 12.4 0.1 0.23 11.5 0.1 1.4 1 0 0 1 1 1 0 CreA protein TPR_1 PF00515.28 KOH01076.1 - 1.3e-21 75.4 2.0 1.3e-06 28.0 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOH01076.1 - 1.2e-19 68.8 1.5 4.3e-05 23.3 0.1 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 KOH01076.1 - 3.8e-17 61.7 0.1 2.3e-06 27.2 0.1 5.5 3 1 2 5 5 5 3 TPR repeat TPR_14 PF13428.6 KOH01076.1 - 1.6e-15 56.4 0.3 0.0006 20.4 0.2 4.7 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOH01076.1 - 4.1e-14 51.5 1.7 0.0081 16.3 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOH01076.1 - 4.4e-13 49.6 0.8 0.0001 22.9 0.2 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOH01076.1 - 2.1e-12 46.5 3.6 0.0078 16.5 0.1 5.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOH01076.1 - 3.7e-11 43.4 0.9 0.011 16.2 0.1 4.4 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_9 PF13371.6 KOH01076.1 - 1.1e-10 41.5 0.1 0.00015 21.8 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 KOH01076.1 - 6.6e-08 32.8 0.2 0.077 13.3 0.0 4.3 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 KOH01076.1 - 3.9e-06 27.1 0.2 4.8 8.0 0.0 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOH01076.1 - 0.00051 20.3 2.1 0.11 12.8 0.7 3.7 2 1 1 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOH01076.1 - 0.00062 19.1 0.6 0.16 11.2 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOH01076.1 - 0.0009 19.4 1.3 0.051 13.8 0.3 2.9 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KOH01076.1 - 0.0023 17.8 0.1 3.9 7.7 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat BTAD PF03704.17 KOH01076.1 - 0.0069 16.8 0.2 0.093 13.2 0.0 2.5 2 1 1 3 3 2 1 Bacterial transcriptional activator domain MIT PF04212.18 KOH01076.1 - 0.0077 16.3 0.4 4.6 7.4 0.0 3.4 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain DUF2989 PF11207.8 KOH01076.1 - 0.012 15.4 0.1 0.033 13.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2989) Fis1_TPR_C PF14853.6 KOH01076.1 - 0.063 13.4 0.3 4 7.6 0.1 2.9 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat KIAA1328 PF15369.6 KOH01076.1 - 0.21 11.4 5.9 0.38 10.5 5.9 1.4 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 TPR_10 PF13374.6 KOH01076.1 - 1.1 9.2 2.9 6.3 6.8 0.9 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4047 PF13256.6 KOH01076.1 - 1.7 8.8 5.9 2.3 8.4 2.9 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4047) Glyco_transf_34 PF05637.12 KOH01077.1 - 7.6e-81 271.3 0.1 9.4e-81 271.0 0.1 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.14 KOH01077.1 - 0.042 13.4 0.0 0.84 9.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF273 Sybindin PF04099.12 KOH01078.1 - 4.3e-34 117.5 3.5 2.3e-13 50.3 0.3 3.1 3 0 0 3 3 3 3 Sybindin-like family Sedlin_N PF04628.13 KOH01078.1 - 1.3e-05 25.3 2.1 2.5e-05 24.4 2.1 1.7 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region Pkinase PF00069.25 KOH01079.1 - 1.2e-46 159.3 0.8 1.1e-39 136.4 0.2 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOH01079.1 - 4.4e-21 75.3 0.2 9.3e-19 67.7 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOH01079.1 - 1.5e-07 31.1 0.0 3.8e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KOH01079.1 - 0.017 15.0 0.1 0.029 14.3 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KOH01079.1 - 0.038 13.3 0.2 0.11 11.8 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APS_kinase PF01583.20 KOH01080.1 - 1.6e-08 34.6 0.0 2e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 KOH01080.1 - 2.3e-07 31.4 0.1 1.1e-06 29.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOH01080.1 - 0.0014 18.8 0.0 0.0019 18.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain SKI PF01202.22 KOH01080.1 - 0.0017 18.5 0.1 0.0032 17.6 0.1 1.6 1 1 0 1 1 1 1 Shikimate kinase NB-ARC PF00931.22 KOH01080.1 - 0.0023 17.2 0.2 0.011 14.9 0.1 1.9 2 0 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 KOH01080.1 - 0.0067 16.8 0.0 0.011 16.1 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain CPT PF07931.12 KOH01080.1 - 0.0076 16.1 0.0 0.012 15.5 0.0 1.4 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_22 PF13401.6 KOH01080.1 - 0.0088 16.3 0.0 0.012 15.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 KOH01080.1 - 0.011 15.7 0.0 0.028 14.3 0.0 1.7 2 0 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 KOH01080.1 - 0.011 15.0 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin ABC_tran PF00005.27 KOH01080.1 - 0.016 15.7 0.0 0.018 15.6 0.0 1.3 1 1 0 1 1 1 0 ABC transporter AAA_17 PF13207.6 KOH01080.1 - 0.02 15.3 0.0 0.049 14.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOH01080.1 - 0.022 14.0 0.1 0.042 13.1 0.1 1.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 KOH01080.1 - 0.023 15.1 0.0 0.042 14.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 KOH01080.1 - 0.037 13.5 0.0 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region CbiA PF01656.23 KOH01080.1 - 0.043 13.9 0.1 0.098 12.7 0.1 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_28 PF13521.6 KOH01080.1 - 0.043 14.1 0.1 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 KOH01080.1 - 0.045 14.2 0.0 0.062 13.7 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 KOH01080.1 - 0.047 13.4 0.2 0.087 12.5 0.1 1.6 1 1 1 2 2 2 0 AAA domain Guanylate_kin PF00625.21 KOH01080.1 - 0.053 13.2 0.0 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 Guanylate kinase T2SSE PF00437.20 KOH01080.1 - 0.056 12.5 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein SRP54 PF00448.22 KOH01080.1 - 0.059 13.0 0.0 0.074 12.7 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 KOH01080.1 - 0.064 13.2 0.1 0.15 11.9 0.0 1.6 1 1 0 2 2 2 0 RsgA GTPase dNK PF01712.19 KOH01080.1 - 0.078 12.8 0.9 7.5 6.4 0.3 2.4 2 1 0 2 2 2 0 Deoxynucleoside kinase AAA_30 PF13604.6 KOH01080.1 - 0.093 12.4 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KOH01080.1 - 0.098 12.7 0.0 0.31 11.1 0.0 1.9 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 KOH01080.1 - 0.13 11.5 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 KOH01080.1 - 0.14 11.7 0.2 0.25 10.9 0.2 1.4 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 KOH01080.1 - 0.15 12.0 0.0 0.33 10.8 0.0 1.6 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 ApbA_C PF08546.11 KOH01082.1 - 5.7e-05 23.3 0.0 9.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal DUF4407 PF14362.6 KOH01082.1 - 8 5.7 7.6 15 4.8 7.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NAC PF01849.18 KOH01083.1 - 1.2e-11 44.3 0.0 2.3e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 NAC domain zf-C2H2 PF00096.26 KOH01084.1 - 6.2e-11 42.1 5.2 8.8e-05 22.7 1.9 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOH01084.1 - 1.2e-09 38.2 4.7 0.0011 19.6 0.0 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOH01084.1 - 6.6e-05 23.1 1.9 0.55 10.6 1.3 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 KOH01084.1 - 0.00017 21.2 1.5 0.42 10.4 0.5 2.4 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2H2_3rep PF18868.1 KOH01084.1 - 0.0002 22.0 2.3 0.02 15.6 0.5 2.4 1 1 1 2 2 2 1 Zinc finger C2H2-type, 3 repeats Zn-ribbon_8 PF09723.10 KOH01084.1 - 0.0088 16.1 1.0 0.02 15.0 1.0 1.6 1 0 0 1 1 1 1 Zinc ribbon domain zf-C2H2_6 PF13912.6 KOH01084.1 - 0.015 15.3 9.4 0.42 10.7 1.6 2.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOH01084.1 - 0.02 15.3 9.3 2.2 8.9 0.2 3.6 3 1 0 3 3 3 0 Zinc-finger double domain zf_UBZ PF18439.1 KOH01084.1 - 0.027 14.1 1.5 4.2 7.1 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger RIG-I_C-RD PF11648.8 KOH01084.1 - 0.028 14.7 0.8 0.069 13.4 0.8 1.7 1 1 0 1 1 1 0 C-terminal domain of RIG-I Spot_14 PF07084.12 KOH01084.1 - 0.031 14.4 0.0 0.044 13.9 0.0 1.3 1 0 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 zf-C2HE PF16278.5 KOH01084.1 - 0.04 14.4 6.3 2.2 8.8 3.2 3.2 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Peptidase_M49 PF03571.15 KOH01084.1 - 0.042 12.2 0.0 0.063 11.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M49 HypA PF01155.19 KOH01084.1 - 0.077 13.0 1.3 0.2 11.7 1.2 1.9 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cript PF10235.9 KOH01084.1 - 0.15 12.7 2.2 0.46 11.1 2.2 1.9 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT zf-ribbon_3 PF13248.6 KOH01084.1 - 0.2 11.1 1.6 0.3 10.5 0.1 2.0 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2_3 PF13878.6 KOH01084.1 - 0.49 10.3 3.5 0.59 10.0 0.4 2.4 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO zinc_ribbon_9 PF14369.6 KOH01084.1 - 0.54 10.6 2.2 1.6 9.0 2.2 1.8 1 1 1 2 2 2 0 zinc-ribbon zf-C2HC_2 PF13913.6 KOH01084.1 - 0.66 9.9 4.8 0.79 9.7 0.5 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type CENP-N PF05238.13 KOH01085.1 - 3e-104 349.6 0.0 3.5e-104 349.4 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like Nab2 PF11517.8 KOH01085.1 - 0.092 13.0 0.1 4.9 7.5 0.0 2.5 2 0 0 2 2 2 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) CLTH PF10607.9 KOH01086.1 - 1.1e-12 48.0 0.1 1.1e-12 48.0 0.1 2.6 2 1 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 KOH01086.1 - 5.7e-05 23.1 0.4 0.0002 21.3 0.4 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOH01086.1 - 0.037 14.0 0.6 0.12 12.4 0.6 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 KOH01086.1 - 0.043 14.1 0.8 0.14 12.5 0.8 2.0 1 0 0 1 1 1 0 Ring finger domain DUF3631 PF12307.8 KOH01086.1 - 0.055 13.7 1.2 5.5 7.2 0.4 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3631) Ku_PK_bind PF08785.11 KOH01086.1 - 0.16 12.1 5.6 1.7 8.8 4.1 2.4 2 0 0 2 2 2 0 Ku C terminal domain like zf-RING_7 PF02591.15 KOH01086.1 - 0.18 12.0 0.1 0.54 10.5 0.1 1.8 1 0 0 1 1 1 0 C4-type zinc ribbon domain DUF2130 PF09903.9 KOH01086.1 - 0.4 9.9 12.9 0.55 9.5 11.6 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2130) ECH_2 PF16113.5 KOH01086.1 - 0.41 10.1 3.6 1.5 8.3 2.6 1.9 2 0 0 2 2 2 0 Enoyl-CoA hydratase/isomerase Tmemb_9 PF05434.11 KOH01086.1 - 0.67 9.8 12.5 0.97 9.3 7.8 2.4 2 0 0 2 2 2 0 TMEM9 Mitofilin PF09731.9 KOH01086.1 - 0.87 8.3 10.2 1.2 7.9 10.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein FapA PF03961.13 KOH01086.1 - 3 6.4 8.5 4.6 5.7 8.5 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Catalase PF00199.19 KOH01087.1 - 2.2e-179 596.5 1.0 2.7e-179 596.2 1.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 KOH01087.1 - 2e-09 37.5 0.0 8.3e-09 35.5 0.0 2.1 2 0 0 2 2 2 1 Catalase-related immune-responsive SET PF00856.28 KOH01088.1 - 6.3e-19 69.0 0.1 9.6e-19 68.4 0.1 1.3 1 0 0 1 1 1 1 SET domain AAA_2 PF07724.14 KOH01089.1 - 5.4e-51 173.1 0.1 1.1e-48 165.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 KOH01089.1 - 5.9e-36 122.5 7.7 7.2e-36 122.3 0.8 2.7 1 1 1 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 KOH01089.1 - 7.5e-27 93.2 0.3 3e-26 91.3 0.3 2.2 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 KOH01089.1 - 8.1e-22 78.1 0.0 4.8e-11 43.2 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOH01089.1 - 2.1e-15 56.9 0.2 1.5e-10 41.2 0.0 3.6 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOH01089.1 - 1.6e-11 44.9 1.2 0.00049 20.5 0.1 4.2 2 2 0 3 3 3 2 AAA ATPase domain ATPase_2 PF01637.18 KOH01089.1 - 5.6e-08 33.0 0.4 0.14 12.0 0.0 3.9 3 1 0 3 3 3 2 ATPase domain predominantly from Archaea AAA_22 PF13401.6 KOH01089.1 - 2.5e-07 31.0 0.1 0.039 14.2 0.0 3.3 2 1 0 2 2 2 2 AAA domain TniB PF05621.11 KOH01089.1 - 2.5e-07 30.3 0.1 0.00019 20.9 0.0 3.9 3 1 0 3 3 3 1 Bacterial TniB protein Sigma54_activat PF00158.26 KOH01089.1 - 5.6e-07 29.4 0.1 2.4e-05 24.1 0.0 2.6 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 KOH01089.1 - 1e-06 28.8 0.0 0.017 15.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 KOH01089.1 - 3.7e-06 26.6 0.1 0.019 14.5 0.0 3.1 2 1 0 2 2 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 KOH01089.1 - 3.9e-06 26.7 0.1 0.041 13.6 0.0 3.1 3 0 0 3 3 3 2 IstB-like ATP binding protein TsaE PF02367.17 KOH01089.1 - 0.00022 21.2 0.0 1.1 9.3 0.0 2.7 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 KOH01089.1 - 0.00025 21.5 0.2 0.13 12.8 0.0 3.1 3 0 0 3 3 2 1 ABC transporter NACHT PF05729.12 KOH01089.1 - 0.00032 20.7 0.0 0.13 12.1 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_18 PF13238.6 KOH01089.1 - 0.00034 21.2 3.5 0.45 11.1 0.0 3.3 4 0 0 4 4 2 2 AAA domain Zeta_toxin PF06414.12 KOH01089.1 - 0.0005 19.4 0.1 0.017 14.4 0.0 3.2 3 1 0 3 3 3 1 Zeta toxin RsgA_GTPase PF03193.16 KOH01089.1 - 0.00056 19.8 0.0 0.45 10.4 0.0 2.9 2 0 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 KOH01089.1 - 0.00072 19.3 0.0 1.7 8.3 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 KOH01089.1 - 0.0014 18.3 0.0 0.26 11.1 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 KOH01089.1 - 0.0015 18.9 0.0 1.9 8.9 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_6 PF12774.7 KOH01089.1 - 0.002 17.2 0.0 0.15 11.0 0.0 2.7 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region PduV-EutP PF10662.9 KOH01089.1 - 0.0021 17.8 0.1 0.43 10.3 0.0 3.1 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_21 PF13304.6 KOH01089.1 - 0.0022 17.9 0.2 4.6 7.0 0.0 3.6 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_28 PF13521.6 KOH01089.1 - 0.0026 18.0 0.0 0.46 10.7 0.0 2.9 3 0 0 3 3 2 1 AAA domain DUF815 PF05673.13 KOH01089.1 - 0.0057 15.9 0.7 3.7 6.6 0.2 3.5 3 1 0 3 3 3 1 Protein of unknown function (DUF815) Roc PF08477.13 KOH01089.1 - 0.0065 16.7 0.0 4.5 7.5 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 KOH01089.1 - 0.0068 16.0 0.0 0.35 10.4 0.0 2.9 4 0 0 4 4 2 1 AAA domain Torsin PF06309.11 KOH01089.1 - 0.0098 16.0 0.0 0.069 13.3 0.0 2.3 2 0 0 2 2 2 1 Torsin T2SSE PF00437.20 KOH01089.1 - 0.012 14.7 0.1 0.13 11.2 0.0 2.5 2 1 0 2 2 2 0 Type II/IV secretion system protein AAA_19 PF13245.6 KOH01089.1 - 0.016 15.5 1.9 15 5.9 0.3 3.9 2 2 0 2 2 2 0 AAA domain AAA_24 PF13479.6 KOH01089.1 - 0.022 14.5 0.0 8 6.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 KOH01089.1 - 0.022 14.2 0.0 1.5 8.1 0.0 2.6 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI SRP54 PF00448.22 KOH01089.1 - 0.028 14.0 0.0 1.9 8.1 0.0 2.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF87 PF01935.17 KOH01089.1 - 0.047 13.8 0.2 1.7 8.7 0.0 2.9 3 0 0 3 3 2 0 Helicase HerA, central domain PhoH PF02562.16 KOH01089.1 - 0.07 12.6 0.1 3.6 7.0 0.0 2.7 3 0 0 3 3 2 0 PhoH-like protein AAA_33 PF13671.6 KOH01089.1 - 0.079 13.1 0.0 7 6.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 KOH01089.1 - 0.082 12.8 0.0 1.5 8.7 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 KOH01089.1 - 0.12 12.5 0.0 9.9 6.3 0.1 3.3 2 1 0 2 2 2 0 50S ribosome-binding GTPase Prefoldin PF02996.17 KOH01089.1 - 1.4 8.9 7.0 19 5.2 0.3 4.1 4 0 0 4 4 4 0 Prefoldin subunit AAA_23 PF13476.6 KOH01089.1 - 5.8 7.4 21.7 14 6.1 0.6 3.7 2 2 0 2 2 2 0 AAA domain bZIP_1 PF00170.21 KOH01090.1 - 2.5e-12 46.7 4.6 2.5e-12 46.7 4.6 3.9 3 1 1 4 4 4 2 bZIP transcription factor HALZ PF02183.18 KOH01090.1 - 0.073 13.3 0.5 0.073 13.3 0.5 4.3 3 2 1 4 4 4 0 Homeobox associated leucine zipper NRBF2 PF08961.10 KOH01090.1 - 0.16 11.5 16.7 0.71 9.5 2.3 3.5 1 1 2 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator ZapB PF06005.12 KOH01090.1 - 0.28 11.7 21.3 3.2 8.2 14.3 3.5 1 1 1 2 2 2 0 Cell division protein ZapB YabA PF06156.13 KOH01090.1 - 8.3 7.1 17.7 8.8 7.0 3.2 3.2 1 1 2 3 3 3 0 Initiation control protein YabA Apc13p PF05839.11 KOH01091.1 - 6.1e-26 90.4 1.4 6.7e-26 90.3 0.5 1.5 2 0 0 2 2 2 1 Apc13p protein Cellulase PF00150.18 KOH01092.1 - 2.8e-12 46.7 3.9 2.8e-12 46.7 3.9 2.1 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Fasciclin PF02469.22 KOH01093.1 - 0.038 14.2 0.1 0.083 13.1 0.1 1.5 1 1 0 1 1 1 0 Fasciclin domain XPG_N PF00752.17 KOH01094.1 - 2.1e-26 92.3 0.1 4.3e-26 91.3 0.1 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 KOH01094.1 - 5.2e-22 78.0 0.0 1.2e-21 76.8 0.0 1.7 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 KOH01094.1 - 0.0022 18.6 0.0 0.012 16.2 0.0 2.3 1 1 1 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.7 KOH01094.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.5 1 0 0 1 1 1 0 XPG domain containing CODH_A_N PF18537.1 KOH01094.1 - 0.071 13.1 0.0 0.79 9.8 0.0 2.5 2 0 0 2 2 2 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain OmpH PF03938.14 KOH01094.1 - 1.7 9.0 4.7 9.9 6.5 1.0 2.6 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Ank_2 PF12796.7 KOH01095.1 - 2.8e-40 136.8 0.6 7.3e-14 52.1 0.0 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) DHHC PF01529.20 KOH01095.1 - 2.9e-24 85.7 3.2 2.9e-24 85.7 3.2 3.0 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_4 PF13637.6 KOH01095.1 - 7.5e-24 83.8 0.1 2.4e-07 31.2 0.0 4.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOH01095.1 - 1.1e-20 71.5 0.2 0.00032 20.9 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 KOH01095.1 - 8.8e-20 70.5 0.0 4.8e-08 33.1 0.0 4.4 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 KOH01095.1 - 1.2e-19 69.7 0.0 3.3e-06 27.3 0.0 5.8 6 0 0 6 6 6 4 Ankyrin repeat Pex2_Pex12 PF04757.14 KOH01096.1 - 6.8e-29 101.1 6.2 1.4e-28 100.0 6.2 1.5 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 KOH01096.1 - 8.7e-09 35.6 17.3 1.5e-08 34.8 17.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KOH01096.1 - 1.1e-07 31.6 16.7 1.6e-07 31.1 16.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOH01096.1 - 2.2e-06 27.4 15.9 3.8e-06 26.7 15.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 KOH01096.1 - 3.1e-06 26.9 15.4 5.7e-06 26.1 15.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOH01096.1 - 1e-05 25.5 10.1 1e-05 25.5 10.1 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOH01096.1 - 1.1e-05 25.1 18.0 2e-05 24.3 18.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOH01096.1 - 0.00055 20.2 12.2 0.0012 19.1 12.2 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KOH01096.1 - 0.0012 18.8 11.2 0.0024 17.8 11.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KOH01096.1 - 0.017 15.3 16.5 0.037 14.2 16.5 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 KOH01097.1 - 2.7e-07 30.4 9.8 2.7e-07 30.4 9.8 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C2H2_4 PF13894.6 KOH01097.1 - 0.24 12.3 0.3 0.24 12.3 0.3 6.7 6 1 0 6 6 6 0 C2H2-type zinc finger WD40 PF00400.32 KOH01098.1 - 1.5e-35 120.6 21.8 2.4e-07 31.3 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH01098.1 - 7.4e-13 48.6 9.5 0.013 15.8 0.0 6.0 2 2 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain CRT10 PF08728.10 KOH01098.1 - 0.0012 17.1 0.6 0.0043 15.3 0.0 2.0 2 1 0 2 2 2 1 CRT10 eIF2A PF08662.11 KOH01098.1 - 0.0031 17.4 0.2 0.017 15.0 0.1 2.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 KOH01098.1 - 0.0059 14.7 0.5 0.009 14.1 0.5 1.3 1 0 0 1 1 1 1 IKI3 family Coatomer_WDAD PF04053.14 KOH01098.1 - 0.013 14.6 0.8 0.021 13.9 0.3 1.6 2 0 0 2 2 2 0 Coatomer WD associated region tRNA-synt_1b PF00579.25 KOH01099.1 - 3.8e-84 282.5 0.0 4.9e-84 282.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Y1_Tnp PF01797.16 KOH01099.1 - 0.029 14.5 0.3 8.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Transposase IS200 like Renin_r PF07850.14 KOH01099.1 - 0.12 13.0 0.1 26 5.5 0.0 2.9 2 1 0 2 2 2 0 Renin receptor-like protein E1-E2_ATPase PF00122.20 KOH01100.1 - 5.2e-46 156.4 0.9 5.2e-46 156.4 0.9 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KOH01100.1 - 2e-38 132.8 0.0 3.2e-38 132.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 KOH01100.1 - 8e-29 99.9 10.6 6.1e-16 58.6 0.9 4.3 4 0 0 4 4 4 2 Heavy-metal-associated domain Hydrolase_3 PF08282.12 KOH01100.1 - 2e-07 31.0 0.3 0.00015 21.6 0.1 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOH01100.1 - 0.00069 20.1 0.0 0.0015 19.0 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Attractin PF08037.11 KOH01100.1 - 0.16 12.0 3.5 0.5 10.4 3.5 1.9 1 0 0 1 1 1 0 Attractin family HAGH_C PF16123.5 KOH01101.1 - 1.5e-19 70.3 0.0 2.4e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 KOH01101.1 - 5.9e-12 46.0 0.0 1.9e-08 34.6 0.0 2.4 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KOH01101.1 - 0.00035 20.2 0.4 0.00087 18.9 0.4 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain CUE PF02845.16 KOH01102.1 - 2.3e-07 30.4 0.0 3.9e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 CUE domain Stm1_N PF09598.10 KOH01102.1 - 0.019 15.8 2.6 0.092 13.6 1.0 2.4 2 0 0 2 2 2 0 Stm1 Pmp3 PF01679.17 KOH01104.1 - 2.3e-17 62.9 8.4 2.4e-17 62.8 8.4 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator STD1 PF17235.2 KOH01105.1 - 1.4e-75 253.5 1.5 3.3e-75 252.2 1.5 1.6 1 0 0 1 1 1 1 STD1/MTH1 DNA_pol_B_thumb PF14791.6 KOH01105.1 - 0.14 12.4 0.2 0.42 10.8 0.2 1.8 1 1 0 1 1 1 0 DNA polymerase beta thumb RNase_H2-Ydr279 PF09468.10 KOH01106.1 - 2e-17 63.8 1.1 1.5e-16 61.0 0.2 2.4 2 1 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 KOH01106.1 - 7.9e-10 38.9 0.1 1.5e-09 38.0 0.1 1.5 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain SPATA6 PF14909.6 KOH01106.1 - 0.12 12.5 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Spermatogenesis-assoc protein 6 RNase_PH PF01138.21 KOH01107.1 - 1.9e-20 73.7 0.0 3.7e-20 72.8 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KOH01107.1 - 1.1e-17 63.8 0.1 3.1e-17 62.4 0.1 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 WTF PF03303.13 KOH01108.1 - 0.0063 16.3 0.1 0.0063 16.3 0.1 1.8 1 1 1 2 2 2 1 WTF protein DUF155 PF02582.14 KOH01109.1 - 4.4e-44 150.7 0.0 9.5e-44 149.6 0.0 1.6 1 1 1 2 2 2 1 Uncharacterised ACR, YagE family COG1723 HGTP_anticodon2 PF12745.7 KOH01110.1 - 2e-90 302.9 2.9 2e-90 302.9 2.9 2.9 3 0 0 3 3 3 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 KOH01110.1 - 7.7e-76 254.9 2.4 1.8e-42 145.6 0.2 3.9 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KOH01110.1 - 1.5e-41 142.4 0.3 1.6e-23 83.4 0.1 3.6 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.22 KOH01110.1 - 4.7e-16 59.1 0.9 4.7e-16 59.1 0.9 2.4 2 0 0 2 2 2 1 RWD domain tRNA-synt_His PF13393.6 KOH01110.1 - 3.6e-14 52.8 0.1 9.6e-14 51.4 0.0 1.7 2 0 0 2 2 2 1 Histidyl-tRNA synthetase SR-25 PF10500.9 KOH01110.1 - 0.00017 21.3 9.3 0.00017 21.3 9.3 3.2 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein APH PF01636.23 KOH01110.1 - 0.013 15.4 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 KOH01110.1 - 0.028 14.1 6.3 0.38 10.3 0.0 3.7 4 0 0 4 4 4 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KOH01110.1 - 0.031 13.6 0.2 0.43 9.9 0.1 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family BUD22 PF09073.10 KOH01110.1 - 5.8 6.1 23.3 0.34 10.2 11.4 2.5 2 0 0 2 2 2 0 BUD22 PAP2 PF01569.21 KOH01111.1 - 1.2e-23 83.4 1.5 1.2e-23 83.4 1.5 1.6 1 1 1 2 2 2 1 PAP2 superfamily KdpA PF03814.15 KOH01111.1 - 0.059 11.6 0.2 0.089 11.0 0.2 1.2 1 0 0 1 1 1 0 Potassium-transporting ATPase A subunit Choline_transpo PF04515.12 KOH01111.1 - 0.3 10.3 5.7 0.95 8.6 2.8 2.1 2 0 0 2 2 2 0 Plasma-membrane choline transporter TPR_MLP1_2 PF07926.12 KOH01112.1 - 0.00092 19.3 22.6 0.00092 19.3 22.6 6.1 3 2 4 7 7 7 4 TPR/MLP1/MLP2-like protein Phg_2220_C PF09524.10 KOH01112.1 - 0.059 13.5 2.5 0.36 10.9 1.6 2.9 1 1 1 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) DUF2514 PF10721.9 KOH01112.1 - 0.15 12.1 0.2 0.15 12.1 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) DDE_Tnp_1_2 PF13586.6 KOH01112.1 - 0.33 11.4 1.7 1.9 8.9 0.1 3.0 3 0 0 3 3 3 0 Transposase DDE domain Methyltransf_1N PF02870.15 KOH01112.1 - 0.69 10.8 6.5 1.8 9.4 0.0 3.9 4 0 0 4 4 4 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain HrpB7 PF09486.10 KOH01112.1 - 5.7 7.3 22.5 2.6 8.4 0.0 5.2 3 2 2 5 5 5 0 Bacterial type III secretion protein (HrpB7) DUF836 PF05768.14 KOH01113.1 - 1.6e-17 63.6 0.4 2e-17 63.3 0.4 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 KOH01113.1 - 3.6e-05 23.9 0.0 0.00016 21.9 0.0 2.1 2 1 0 2 2 2 1 Glutaredoxin Thioredoxin_2 PF13098.6 KOH01113.1 - 0.00032 21.1 0.4 0.00038 20.9 0.4 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain zf-RVT PF13966.6 KOH01113.1 - 0.0085 16.8 0.1 0.014 16.1 0.1 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase AhpC-TSA PF00578.21 KOH01113.1 - 0.031 14.2 0.1 0.038 13.9 0.1 1.1 1 0 0 1 1 1 0 AhpC/TSA family TraF PF13728.6 KOH01113.1 - 0.037 13.8 0.0 0.043 13.6 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_8 PF13905.6 KOH01113.1 - 0.039 14.3 0.1 0.054 13.8 0.1 1.4 1 0 0 1 1 1 0 Thioredoxin-like Redoxin PF08534.10 KOH01113.1 - 0.062 13.0 0.0 0.079 12.7 0.0 1.1 1 0 0 1 1 1 0 Redoxin Inositol_P PF00459.25 KOH01114.1 - 5e-73 246.0 0.0 5.8e-73 245.7 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family MAGE PF01454.19 KOH01115.1 - 3.1e-46 157.8 0.2 1.1e-45 156.0 0.2 1.7 1 1 0 1 1 1 1 MAGE family SMC_ScpB PF04079.16 KOH01115.1 - 0.06 13.0 0.5 0.88 9.2 0.0 2.5 3 0 0 3 3 3 0 Segregation and condensation complex subunit ScpB Type2_restr_D3 PF16902.5 KOH01115.1 - 0.063 13.2 2.3 0.42 10.6 0.1 3.1 4 0 0 4 4 4 0 Type-2 restriction enzyme D3 domain CTD_bind PF04818.13 KOH01116.1 - 6.6e-13 49.3 0.7 1.4e-12 48.3 0.2 1.9 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CTK3 PF12243.8 KOH01116.1 - 0.082 12.9 0.1 0.17 11.9 0.1 1.6 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 Occludin_ELL PF07303.13 KOH01116.1 - 0.33 11.7 3.5 0.76 10.5 0.7 2.8 2 1 1 3 3 3 0 Occludin homology domain DEAD PF00270.29 KOH01117.1 - 7.2e-23 81.2 0.0 1.9e-22 79.9 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 KOH01117.1 - 2.2e-19 70.0 0.1 7.4e-19 68.3 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 KOH01117.1 - 1.3e-13 51.3 0.4 7.8e-13 48.8 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOH01117.1 - 6.8e-09 36.0 0.1 1.4e-08 34.9 0.1 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 KOH01117.1 - 0.0093 16.3 0.3 0.019 15.2 0.3 1.6 1 0 0 1 1 1 1 DNA replication factor CDT1 like SRX PF09201.10 KOH01118.1 - 1e-65 220.1 6.1 2.2e-65 219.0 6.1 1.6 1 0 0 1 1 1 1 SRX, signal recognition particle receptor alpha subunit SRP54 PF00448.22 KOH01118.1 - 2.6e-47 161.0 0.1 2.3e-28 99.2 0.1 2.4 1 1 1 2 2 2 2 SRP54-type protein, GTPase domain SRP54_N PF02881.19 KOH01118.1 - 8.4e-07 29.1 1.6 2e-06 27.9 0.2 2.4 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain SRP-alpha_N PF04086.13 KOH01118.1 - 9.1e-07 29.1 1.3 1.9e-06 28.0 1.3 1.6 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal AAA_31 PF13614.6 KOH01118.1 - 0.00061 19.8 0.1 0.0072 16.3 0.1 2.6 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 KOH01118.1 - 0.00062 18.8 0.0 0.0017 17.4 0.0 1.8 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 KOH01118.1 - 0.002 18.2 0.1 0.0062 16.6 0.1 1.8 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 KOH01118.1 - 0.0028 16.9 0.0 0.15 11.2 0.0 2.7 2 0 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 KOH01118.1 - 0.017 14.6 0.0 0.035 13.6 0.0 1.5 1 1 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_30 PF13604.6 KOH01118.1 - 0.061 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOH01118.1 - 0.11 12.7 0.0 0.56 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain RNB PF00773.19 KOH01119.1 - 3.1e-61 207.5 0.0 6.6e-61 206.4 0.0 1.5 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 KOH01119.1 - 7e-23 80.4 0.0 2.3e-22 78.8 0.0 2.0 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 KOH01119.1 - 7.2e-22 77.5 0.0 2.7e-21 75.7 0.0 2.1 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 KOH01119.1 - 1.2e-06 28.6 0.1 0.00041 20.4 0.0 3.3 4 0 0 4 4 4 1 Cold shock domain Rrp44_CSD1 PF17216.3 KOH01119.1 - 0.0022 17.7 0.1 0.0094 15.7 0.1 2.1 1 0 0 1 1 1 1 Rrp44-like cold shock domain OB_RNB PF08206.11 KOH01119.1 - 0.0029 17.2 0.1 1.1 9.1 0.0 2.6 2 0 0 2 2 2 2 Ribonuclease B OB domain HisG_C PF08029.11 KOH01119.1 - 0.057 13.6 0.0 0.17 12.1 0.0 1.8 1 0 0 1 1 1 0 HisG, C-terminal domain Rrp44_S1 PF17215.3 KOH01119.1 - 0.072 13.0 0.0 0.22 11.5 0.0 1.8 1 0 0 1 1 1 0 S1 domain Alpha-mann_mid PF09261.11 KOH01119.1 - 0.68 10.1 2.7 0.52 10.5 0.1 2.1 2 0 0 2 2 2 0 Alpha mannosidase middle domain SseC PF04888.12 KOH01119.1 - 3.5 7.1 5.3 1.5 8.3 2.8 1.5 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family Pyridoxal_deC PF00282.19 KOH01120.1 - 7.7e-24 84.1 0.0 1.3e-23 83.4 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 KOH01120.1 - 2e-09 36.9 0.0 1.1e-08 34.4 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KOH01120.1 - 1.4e-08 34.5 0.0 2.4e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 KOH01120.1 - 0.023 13.3 0.0 0.035 12.6 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme SepSecS PF05889.13 KOH01120.1 - 0.17 10.5 0.0 0.25 10.0 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS HDA2-3 PF11496.8 KOH01121.1 - 5e-71 239.3 6.4 5e-71 239.3 6.4 2.0 3 0 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 Mhr1 PF12829.7 KOH01122.1 - 9.3e-25 86.5 2.1 1.8e-24 85.6 2.1 1.5 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination FA_hydroxylase PF04116.13 KOH01123.1 - 2.3e-22 79.8 25.2 2.9e-22 79.4 14.5 2.2 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily OSCP PF00213.18 KOH01124.1 - 5e-43 147.2 0.7 5.9e-43 147.0 0.7 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit SKIP_SNW PF02731.15 KOH01124.1 - 0.043 13.5 0.1 0.17 11.5 0.0 1.9 1 1 1 2 2 2 0 SKIP/SNW domain AATF-Che1 PF13339.6 KOH01125.1 - 5.4e-25 88.7 9.1 5.4e-25 88.7 9.1 3.1 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 KOH01125.1 - 5.7e-24 84.4 0.1 5.7e-24 84.4 0.1 3.7 3 1 1 4 4 4 1 Apoptosis-antagonizing transcription factor, C-terminal AA_kinase PF00696.28 KOH01126.1 - 1.6e-35 122.8 1.1 5.9e-35 121.0 0.4 2.0 2 1 1 3 3 3 1 Amino acid kinase family PUA PF01472.20 KOH01126.1 - 2.1e-21 75.6 0.0 4.5e-21 74.6 0.0 1.6 1 0 0 1 1 1 1 PUA domain SL4P PF17618.2 KOH01126.1 - 0.12 12.4 1.0 5 7.2 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized Strongylid L4 protein CPSF_A PF03178.15 KOH01127.1 - 2.7e-90 302.9 0.0 1.2e-89 300.8 0.0 2.2 2 0 0 2 2 2 1 CPSF A subunit region MPP6 PF10175.9 KOH01127.1 - 0.12 12.9 4.3 1.5 9.3 0.3 2.6 2 0 0 2 2 2 0 M-phase phosphoprotein 6 FAM176 PF14851.6 KOH01127.1 - 1 9.0 6.9 7.2 6.3 2.2 2.3 2 0 0 2 2 2 0 FAM176 family PIG-F PF06699.11 KOH01128.1 - 6.4e-24 85.1 22.8 1.1e-22 81.1 22.8 2.0 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F Gly-zipper_Omp PF13488.6 KOH01128.1 - 0.076 13.0 0.7 0.16 12.0 0.7 1.5 1 0 0 1 1 1 0 Glycine zipper DUF2070 PF09843.9 KOH01128.1 - 0.32 9.2 7.6 0.36 9.1 7.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Zn_clus PF00172.18 KOH01129.1 - 2e-08 34.2 6.5 4.1e-08 33.2 6.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pro_isomerase PF00160.21 KOH01130.1 - 1.4e-45 155.4 0.2 1.9e-45 154.9 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HIT PF01230.23 KOH01131.1 - 5.1e-14 52.8 0.0 8.6e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 HIT domain F-box-like PF12937.7 KOH01132.1 - 0.0025 17.7 0.4 0.012 15.5 0.0 2.4 2 0 0 2 2 2 1 F-box-like LRR_5 PF13306.6 KOH01132.1 - 0.47 10.4 10.8 1.9 8.5 1.6 3.4 1 1 2 3 3 3 0 BspA type Leucine rich repeat region (6 copies) F-box PF00646.33 KOH01132.1 - 8.6 6.4 8.6 64 3.6 0.1 4.1 4 0 0 4 4 4 0 F-box domain MIR PF02815.19 KOH01133.1 - 5.4e-08 32.9 0.0 3.1e-07 30.4 0.0 2.0 1 1 1 2 2 2 1 MIR domain PMT PF02366.18 KOH01133.1 - 0.0041 16.7 17.1 0.0041 16.7 17.1 3.0 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Med21 PF11221.8 KOH01134.1 - 1.2e-45 155.4 5.3 1.4e-45 155.1 5.3 1.1 1 0 0 1 1 1 1 Subunit 21 of Mediator complex Med9 PF07544.13 KOH01134.1 - 0.00014 21.8 2.1 0.0006 19.8 2.1 2.1 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 DUF2200 PF09966.9 KOH01134.1 - 0.02 15.0 0.8 0.32 11.1 0.0 2.3 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2200) ING PF12998.7 KOH01134.1 - 0.063 13.9 3.3 0.38 11.4 3.0 2.2 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding SUIM_assoc PF16619.5 KOH01135.1 - 0.00029 20.9 3.4 0.0011 19.0 3.4 2.1 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 AdHead_fibreRBD PF16812.5 KOH01135.1 - 0.016 15.0 0.6 0.028 14.3 0.6 1.3 1 0 0 1 1 1 0 C-terminal head domain of the fowl adenovirus type 1 long fibre PBD PF00786.28 KOH01135.1 - 0.18 12.1 3.6 0.37 11.2 2.0 2.5 2 1 0 2 2 2 0 P21-Rho-binding domain PH_TFIIH PF08567.11 KOH01137.1 - 2.6e-18 66.1 0.2 2.6e-18 66.1 0.2 2.0 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.17 KOH01137.1 - 3.3e-18 65.4 4.3 1.6e-10 40.8 0.6 3.0 3 0 0 3 3 3 2 BSD domain DUF559 PF04480.12 KOH01137.1 - 0.13 12.1 0.6 0.62 9.9 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF559) O-antigen_lig PF13425.6 KOH01137.1 - 4.1 6.1 4.8 7.7 5.2 4.8 1.4 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Brix PF04427.18 KOH01138.1 - 9.4e-50 169.4 3.4 9.4e-50 169.4 3.4 1.5 2 0 0 2 2 2 1 Brix domain DUF2514 PF10721.9 KOH01138.1 - 7.2 6.6 14.8 0.079 13.0 5.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) FYVE PF01363.21 KOH01139.1 - 7.4e-20 70.9 14.4 7.4e-20 70.9 14.4 3.4 2 1 1 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 KOH01139.1 - 1.5e-07 31.6 3.1 1.5e-07 31.6 3.1 4.9 4 2 2 6 6 6 1 Ring finger domain zf-RING_11 PF17123.5 KOH01139.1 - 4.5e-06 26.3 5.0 4.5e-06 26.3 5.0 3.4 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KOH01139.1 - 6.8e-05 22.8 3.1 6.8e-05 22.8 3.1 4.8 5 1 0 5 5 5 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOH01139.1 - 0.0017 18.2 3.2 0.0017 18.2 3.2 4.8 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOH01139.1 - 0.004 17.0 3.5 0.004 17.0 3.5 5.2 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 KOH01139.1 - 0.011 15.9 2.2 0.011 15.9 2.2 3.7 4 0 0 4 4 4 0 FANCL C-terminal domain zinc_ribbon_2 PF13240.6 KOH01139.1 - 0.028 14.2 1.2 0.028 14.2 1.2 5.0 6 1 0 6 6 5 0 zinc-ribbon domain RNF220 PF15926.5 KOH01139.1 - 0.093 12.3 19.1 0.0091 15.6 13.5 2.3 2 1 0 2 2 2 0 E3 ubiquitin-protein ligase RNF220 zf-RING_5 PF14634.6 KOH01139.1 - 0.47 10.4 32.9 0.12 12.3 4.0 5.3 5 0 0 5 5 5 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KOH01139.1 - 1.7 8.8 25.3 1.2 9.4 2.3 5.2 4 2 1 5 5 5 0 zinc finger of C3HC4-type, RING BHD_3 PF10405.9 KOH01140.1 - 2.4e-15 56.7 0.1 4.5e-15 55.8 0.1 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 KOH01140.1 - 2.9e-09 36.6 0.0 8.5e-09 35.1 0.0 1.9 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Rad4 PF03835.15 KOH01140.1 - 5.4e-05 22.9 0.3 0.00018 21.2 0.3 1.9 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_2 PF10404.9 KOH01140.1 - 0.07 14.1 1.5 0.091 13.7 0.1 2.0 2 0 0 2 2 2 0 Rad4 beta-hairpin domain 2 Com_YlbF PF06133.11 KOH01140.1 - 8.8 7.0 10.5 0.62 10.7 0.8 2.9 3 0 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA Ins_P5_2-kin PF06090.12 KOH01141.1 - 1.3e-15 57.6 0.6 4e-14 52.8 0.6 2.1 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Methyltransf_23 PF13489.6 KOH01142.1 - 1.1e-20 74.2 0.3 2.1e-20 73.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOH01142.1 - 7e-15 55.6 0.2 3.4e-14 53.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOH01142.1 - 3.3e-11 43.7 0.0 1.7e-10 41.5 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOH01142.1 - 1.2e-09 37.9 1.1 7.2e-08 32.1 0.1 2.6 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 KOH01142.1 - 6e-08 33.2 0.0 6.8e-07 29.9 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOH01142.1 - 1.8e-06 27.8 0.0 4.8e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain YrhC PF14143.6 KOH01142.1 - 0.056 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 YrhC-like protein HIM1 PF08732.10 KOH01143.1 - 4.6e-65 218.3 0.0 8e-65 217.5 0.0 1.4 1 0 0 1 1 1 1 HIM1 CENP-O PF09496.10 KOH01144.1 - 6.4e-14 52.4 1.2 1.1e-13 51.7 0.1 1.9 2 1 0 2 2 2 1 Cenp-O kinetochore centromere component APG6_N PF17675.1 KOH01144.1 - 0.011 16.3 1.5 0.027 15.0 1.5 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region JIP_LZII PF16471.5 KOH01144.1 - 0.026 14.7 2.9 0.081 13.1 2.9 1.9 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II FlgN PF05130.12 KOH01144.1 - 0.037 14.6 0.4 0.081 13.4 0.4 1.6 1 0 0 1 1 1 0 FlgN protein YscO PF07321.12 KOH01144.1 - 0.044 13.7 0.3 0.091 12.7 0.3 1.5 1 0 0 1 1 1 0 Type III secretion protein YscO Spc24 PF08286.11 KOH01144.1 - 0.082 13.2 2.8 0.57 10.5 1.2 2.5 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Prefoldin_2 PF01920.20 KOH01144.1 - 0.15 12.0 5.7 0.4 10.7 4.9 2.1 2 0 0 2 2 2 0 Prefoldin subunit FlaC_arch PF05377.11 KOH01144.1 - 0.18 12.2 3.0 0.53 10.7 3.0 1.9 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Tup_N PF08581.10 KOH01144.1 - 0.22 11.9 3.9 2.8 8.3 1.2 2.6 2 0 0 2 2 2 0 Tup N-terminal Scs3p PF10261.9 KOH01145.1 - 3.3e-17 62.8 17.1 5.5e-14 52.3 17.1 2.5 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.21 KOH01145.1 - 1.7e-05 24.6 7.7 0.0022 17.8 6.4 2.8 2 1 0 2 2 2 2 PAP2 superfamily Ubiq-assoc PF09145.10 KOH01146.1 - 3.5e-22 78.1 0.8 9.8e-22 76.7 0.8 1.8 1 0 0 1 1 1 1 Ubiquitin-associated TPR_1 PF00515.28 KOH01146.1 - 0.00029 20.5 0.1 7 6.7 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOH01146.1 - 0.00083 19.3 0.0 2.8 8.3 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOH01146.1 - 0.068 13.5 0.0 1.5 9.2 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Apis_Csd PF11671.8 KOH01146.1 - 0.08 13.0 1.3 0.19 11.8 1.3 1.6 1 0 0 1 1 1 0 Complementary sex determiner protein DnaJ PF00226.31 KOH01146.1 - 0.081 13.1 0.1 0.22 11.7 0.1 1.7 1 0 0 1 1 1 0 DnaJ domain DUF5525 PF17663.1 KOH01146.1 - 0.8 7.7 6.9 1.3 7.0 0.0 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5525) DASH_Dad4 PF08650.10 KOH01147.1 - 2.1e-33 114.1 5.5 2.3e-33 114.0 5.5 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 DivIC PF04977.15 KOH01147.1 - 0.056 13.2 0.5 0.08 12.7 0.5 1.3 1 0 0 1 1 1 0 Septum formation initiator Img2 PF05046.14 KOH01147.1 - 0.09 13.1 0.1 0.1 12.9 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) Asparaginase PF00710.20 KOH01148.1 - 1.4e-55 187.8 0.0 3.1e-55 186.7 0.0 1.6 2 0 0 2 2 2 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 KOH01148.1 - 1.1e-17 64.3 0.0 2.5e-17 63.1 0.0 1.6 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ribosomal_L19 PF01245.20 KOH01148.1 - 0.0034 17.3 0.0 0.53 10.2 0.0 2.6 3 0 0 3 3 3 2 Ribosomal protein L19 PucR PF07905.11 KOH01148.1 - 0.071 13.4 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family PBP PF01161.20 KOH01149.1 - 2.9e-06 27.6 0.0 6.9e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein ATP-synt_E PF05680.12 KOH01150.1 - 1.5e-19 70.1 0.1 1.6e-19 70.0 0.1 1.0 1 0 0 1 1 1 1 ATP synthase E chain FYVE PF01363.21 KOH01151.1 - 6.3e-20 71.1 19.4 3.6e-16 59.0 1.4 3.3 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.8 KOH01151.1 - 5.3e-14 51.7 0.6 5.3e-14 51.7 0.6 2.6 3 0 0 3 3 3 1 Rabenosyn Rab binding domain DZR PF12773.7 KOH01151.1 - 0.0095 15.9 14.9 0.033 14.2 2.3 3.8 4 0 0 4 4 4 2 Double zinc ribbon zf-C2H2_6 PF13912.6 KOH01151.1 - 0.012 15.6 0.1 0.012 15.6 0.1 4.1 5 0 0 5 5 5 0 C2H2-type zinc finger zf-Di19 PF05605.12 KOH01151.1 - 0.027 14.8 0.1 0.027 14.8 0.1 2.9 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.5 KOH01151.1 - 0.038 13.9 0.1 0.13 12.1 0.1 2.0 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) ABC_tran_CTD PF16326.5 KOH01151.1 - 0.053 13.8 1.8 0.29 11.4 0.0 3.3 4 0 0 4 4 3 0 ABC transporter C-terminal domain zf-C2H2_4 PF13894.6 KOH01151.1 - 0.084 13.8 0.1 0.084 13.8 0.1 6.3 7 1 1 8 8 7 0 C2H2-type zinc finger zf-C2H2 PF00096.26 KOH01151.1 - 0.14 12.7 0.1 0.14 12.7 0.1 5.8 5 1 1 6 6 5 0 Zinc finger, C2H2 type HypA PF01155.19 KOH01151.1 - 0.46 10.5 6.6 1.7 8.7 1.5 3.1 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2HC_2 PF13913.6 KOH01151.1 - 0.6 10.1 0.0 0.6 10.1 0.0 4.1 5 0 0 5 5 5 0 zinc-finger of a C2HC-type CorA PF01544.18 KOH01151.1 - 1.6 8.0 6.2 1.5 8.1 2.1 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein zf-met PF12874.7 KOH01151.1 - 1.9 9.0 12.4 1.6 9.3 0.1 4.2 4 0 0 4 4 4 0 Zinc-finger of C2H2 type WD40 PF00400.32 KOH01152.1 - 2.4e-12 47.2 14.0 0.13 13.2 0.0 8.3 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH01152.1 - 1.8e-10 41.0 3.7 0.0077 16.5 0.1 6.4 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain DUF1921 PF09081.10 KOH01152.1 - 0.72 10.1 3.0 24 5.3 0.1 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF1921) Cnd3 PF12719.7 KOH01153.1 - 9e-93 310.7 8.3 1.4e-92 310.1 5.0 2.4 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 KOH01153.1 - 2.8e-08 34.0 0.1 0.00044 20.6 0.0 3.0 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.22 KOH01153.1 - 4e-05 23.5 1.2 3.6 8.1 0.0 5.0 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 KOH01153.1 - 0.007 16.4 2.4 0.021 14.9 0.1 3.1 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KOH01153.1 - 0.099 13.2 0.7 3.1 8.5 0.1 3.7 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region VASt PF16016.5 KOH01154.1 - 1.7e-74 249.3 5.9 2.4e-36 125.4 0.2 3.1 2 0 0 2 2 2 2 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 KOH01154.1 - 4.3e-26 91.0 0.0 1.1e-25 89.7 0.0 1.8 1 0 0 1 1 1 1 GRAM domain Methyltransf_12 PF08242.12 KOH01154.1 - 8 7.3 9.8 0.24 12.2 0.3 3.5 4 0 0 4 4 4 0 Methyltransferase domain Skp1 PF01466.19 KOH01155.1 - 8.8e-25 86.6 0.1 1.5e-24 85.8 0.1 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 KOH01155.1 - 3e-15 56.2 0.2 3.4e-07 30.3 0.1 2.5 2 0 0 2 2 2 2 Skp1 family, tetramerisation domain rRNA_processing PF08524.11 KOH01155.1 - 0.21 11.6 3.3 0.35 10.9 3.1 1.4 1 1 0 1 1 1 0 rRNA processing Secretin_N_2 PF07655.13 KOH01155.1 - 0.35 11.4 5.4 0.56 10.8 5.4 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain RRN3 PF05327.11 KOH01155.1 - 1.5 7.3 6.0 1.7 7.1 6.0 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF3245 PF11595.8 KOH01155.1 - 3.9 7.9 20.4 0.39 11.2 12.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3245) CENP-B_dimeris PF09026.10 KOH01155.1 - 6.5 7.2 27.5 0.24 11.8 16.2 2.3 1 1 1 2 2 2 0 Centromere protein B dimerisation domain TFB6 PF17110.5 KOH01155.1 - 6.6 6.4 9.0 15 5.3 9.0 1.7 1 1 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Peroxin-3 PF04882.12 KOH01156.1 - 3.9e-100 336.1 20.4 1.2e-77 261.9 12.7 2.0 1 1 1 2 2 2 2 Peroxin-3 Med22 PF06179.12 KOH01156.1 - 0.042 14.1 2.3 0.071 13.3 0.5 2.3 2 0 0 2 2 2 0 Surfeit locus protein 5 subunit 22 of Mediator complex Thioredoxin_7 PF13899.6 KOH01157.1 - 2.2e-25 88.6 0.1 4.8e-25 87.5 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.20 KOH01157.1 - 1.9e-17 63.2 0.0 3.9e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 KOH01157.1 - 3.5e-14 52.3 0.5 7.1e-14 51.3 0.5 1.6 1 0 0 1 1 1 1 UBA-like domain C2-set PF05790.15 KOH01157.1 - 0.00078 19.6 0.2 0.0022 18.2 0.2 1.7 1 0 0 1 1 1 1 Immunoglobulin C2-set domain Peptidase_C13 PF01650.18 KOH01158.1 - 1.4e-46 159.1 1.0 2.1e-46 158.5 1.0 1.2 1 0 0 1 1 1 1 Peptidase C13 family Peptidase_C14 PF00656.22 KOH01158.1 - 9.8e-05 22.4 0.8 0.00027 21.0 0.4 1.7 1 1 1 2 2 2 1 Caspase domain RNA_binding PF01877.17 KOH01158.1 - 0.027 14.7 0.6 0.07 13.4 0.2 1.8 2 0 0 2 2 2 0 RNA binding ResIII PF04851.15 KOH01159.1 - 3.2e-27 95.6 0.0 3.2e-27 95.6 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOH01159.1 - 6.1e-17 61.9 0.0 1.5e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOH01159.1 - 3.4e-15 56.3 1.0 3.6e-13 49.8 0.1 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOH01159.1 - 1e-05 25.8 0.0 2.9e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 KOH01159.1 - 0.00024 20.4 0.0 0.00073 18.9 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ERCC3_RAD25_C PF16203.5 KOH01159.1 - 0.02 14.1 0.0 0.042 13.0 0.0 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase NepR PF18557.1 KOH01159.1 - 0.081 12.6 0.8 2.6 7.7 0.0 3.0 3 0 0 3 3 3 0 Anti-sigma factor NepR Tcf25 PF04910.14 KOH01160.1 - 4.1e-81 272.8 2.1 6e-81 272.2 2.1 1.3 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Pro-NT_NN PF07421.11 KOH01160.1 - 0.063 13.5 2.4 0.19 12.0 2.4 1.8 1 0 0 1 1 1 0 Neurotensin/neuromedin N precursor SNF2_N PF00176.23 KOH01161.1 - 1.1e-66 224.9 0.3 2.4e-66 223.9 0.3 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOH01161.1 - 1e-18 67.7 0.0 1.8e-17 63.7 0.1 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 KOH01161.1 - 2.1e-15 56.8 9.6 2.1e-15 56.8 9.6 3.0 1 1 1 2 2 2 1 HSA ResIII PF04851.15 KOH01161.1 - 1.6e-12 47.7 0.0 1.6e-12 47.7 0.0 3.6 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOH01161.1 - 3.2e-06 27.0 0.0 1e-05 25.4 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Smoothelin PF12510.8 KOH01161.1 - 0.64 10.1 4.0 0.88 9.7 0.3 2.8 2 0 0 2 2 2 0 Smoothelin cytoskeleton protein Top6b_C PF18000.1 KOH01162.1 - 0.0073 16.5 0.0 0.73 10.0 0.0 2.6 2 0 0 2 2 2 1 Type 2 DNA topoisomerase 6 subunit B C-terminal domain EspG PF06872.11 KOH01162.1 - 0.056 12.0 0.5 0.12 10.9 0.5 1.5 1 0 0 1 1 1 0 EspG protein IBN_N PF03810.19 KOH01162.1 - 0.084 12.8 0.3 1.1 9.2 0.0 3.1 3 0 0 3 3 3 0 Importin-beta N-terminal domain Orbi_VP6 PF01516.16 KOH01162.1 - 0.12 11.9 0.4 0.18 11.3 0.4 1.1 1 0 0 1 1 1 0 Orbivirus helicase VP6 Xpo1 PF08389.12 KOH01162.1 - 1.9 8.5 13.8 1.2 9.2 8.7 3.3 2 1 0 2 2 2 0 Exportin 1-like protein MMR_HSR1 PF01926.23 KOH01163.1 - 1.4e-15 57.4 0.1 2.4e-15 56.6 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOH01163.1 - 1.9e-06 27.5 0.1 2.7e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KOH01163.1 - 5.8e-06 26.3 0.3 0.0013 18.7 0.2 2.3 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 KOH01163.1 - 0.0004 19.8 0.2 0.00081 18.8 0.1 1.7 2 0 0 2 2 2 1 AIG1 family SRPRB PF09439.10 KOH01163.1 - 0.0044 16.5 0.2 0.0091 15.4 0.2 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 KOH01163.1 - 0.0072 16.4 2.8 2.5 8.1 0.9 2.6 2 1 1 3 3 3 2 Dynamin family Roc PF08477.13 KOH01163.1 - 0.079 13.2 0.9 0.16 12.2 0.1 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ribosomal_S15 PF00312.22 KOH01164.1 - 7.2e-30 103.0 1.2 1.8e-29 101.8 0.2 2.1 2 0 0 2 2 2 1 Ribosomal protein S15 MatE PF01554.18 KOH01165.1 - 1.5e-62 210.0 33.9 5.9e-42 143.1 6.9 2.9 3 0 0 3 3 3 2 MatE Fcf1 PF04900.12 KOH01166.1 - 1.1e-34 118.8 0.2 1.9e-34 118.0 0.2 1.4 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 KOH01166.1 - 2.9e-14 53.4 0.0 4.3e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 PIN like domain Imm-NTF2 PF15655.6 KOH01166.1 - 0.017 15.4 0.0 0.037 14.3 0.0 1.5 1 0 0 1 1 1 0 NTF2 fold immunity protein tRNA-synt_1d PF00750.19 KOH01167.1 - 2.3e-122 408.3 6.3 2.8e-122 408.0 6.3 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 KOH01167.1 - 1.5e-29 102.5 0.1 3.8e-28 98.1 0.0 2.4 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 KOH01167.1 - 4.9e-10 39.8 0.0 3.5e-09 37.1 0.0 2.4 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain Svf1_C PF17187.4 KOH01169.1 - 3.8e-66 222.0 1.6 9.4e-66 220.7 1.6 1.7 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 KOH01169.1 - 2.6e-60 203.2 0.0 4.6e-60 202.4 0.0 1.4 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Astro_capsid_p PF12226.8 KOH01169.1 - 1.7 7.7 11.1 0.02 14.1 2.3 1.9 2 0 0 2 2 2 0 Turkey astrovirus capsid protein GEMIN8 PF15348.6 KOH01169.1 - 1.7 8.9 6.7 5.7 7.2 1.4 2.2 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 DARPP-32 PF05395.12 KOH01169.1 - 4 7.6 11.3 1.1 9.5 1.8 2.3 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 GEN1_C PF18380.1 KOH01169.1 - 7.2 7.6 10.5 12 6.9 2.7 2.5 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain Sod_Fe_C PF02777.18 KOH01170.1 - 1.6e-11 44.2 0.0 6.5e-05 23.0 0.0 2.5 1 1 1 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Activator-TraM PF11657.8 KOH01170.1 - 0.14 12.0 0.4 8.5 6.2 0.1 2.3 2 0 0 2 2 2 0 Transcriptional activator TraM Pal1 PF08316.11 KOH01171.1 - 2.6e-52 177.2 2.4 2.6e-52 177.2 2.4 2.8 4 0 0 4 4 4 1 Pal1 cell morphology protein Asp PF00026.23 KOH01172.1 - 2.8e-25 89.4 0.8 2.8e-25 89.4 0.8 3.1 2 2 1 3 3 3 1 Eukaryotic aspartyl protease SBE2 PF17076.5 KOH01174.1 - 2.6e-260 866.2 31.2 3.1e-260 865.9 31.2 1.0 1 0 0 1 1 1 1 SBE2, cell-wall formation SIX1_SD PF16878.5 KOH01174.1 - 0.064 13.8 0.1 6.9 7.2 0.1 2.7 2 0 0 2 2 2 0 Transcriptional regulator, SIX1, N-terminal SD domain PQ-loop PF04193.14 KOH01175.1 - 1.1e-35 121.2 11.6 1e-18 66.8 1.2 2.5 2 0 0 2 2 2 2 PQ loop repeat DUF679 PF05078.12 KOH01175.1 - 0.0041 17.1 0.0 0.013 15.5 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF679) ER_lumen_recept PF00810.18 KOH01175.1 - 0.0067 17.3 0.8 0.07 13.9 0.0 2.7 2 1 1 3 3 3 1 ER lumen protein retaining receptor Pyr_redox_2 PF07992.14 KOH01176.1 - 9.9e-52 176.0 0.1 1.1e-51 175.8 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOH01176.1 - 2.5e-18 66.4 0.4 7.8e-16 58.4 0.0 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOH01176.1 - 2.2e-15 56.7 0.1 5.3e-14 52.2 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOH01176.1 - 6.4e-06 25.5 0.6 0.53 9.3 0.1 4.0 4 0 0 4 4 4 2 Glucose inhibited division protein A NAD_binding_7 PF13241.6 KOH01176.1 - 0.00023 21.6 0.0 0.064 13.7 0.0 2.3 2 0 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_8 PF13450.6 KOH01176.1 - 0.00033 20.8 0.0 0.032 14.4 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KOH01176.1 - 0.0038 16.5 0.0 0.015 14.5 0.1 1.9 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 KOH01176.1 - 0.0059 15.7 1.4 1.1 8.2 0.3 2.5 2 1 0 2 2 2 2 FAD binding domain K_oxygenase PF13434.6 KOH01176.1 - 0.014 14.5 0.1 1.4 8.0 0.0 3.3 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 KOH01176.1 - 0.015 14.5 0.1 2.4 7.3 0.1 2.2 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.24 KOH01176.1 - 0.047 13.3 0.1 3.5 7.1 0.0 2.4 1 1 0 2 2 2 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 KOH01176.1 - 0.055 13.5 0.3 9.2 6.3 0.0 2.6 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 KOH01176.1 - 0.072 11.8 0.3 2.4 6.8 0.1 2.6 2 1 1 3 3 3 0 HI0933-like protein FMO-like PF00743.19 KOH01176.1 - 0.14 10.5 0.0 0.19 10.1 0.0 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Glycos_transf_3 PF00591.21 KOH01177.1 - 1e-86 290.7 0.0 1.3e-86 290.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 KOH01177.1 - 1e-10 41.3 0.0 2e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Spc110_C PF18520.1 KOH01178.1 - 1.4e-22 79.1 2.8 2.2e-22 78.4 0.4 2.8 2 0 0 2 2 2 1 Spindle pole body component 110 C-terminal domain Filament PF00038.21 KOH01178.1 - 5.8e-08 32.7 137.0 0.0011 18.6 43.5 6.1 1 1 4 5 5 5 4 Intermediate filament protein HOOK PF05622.12 KOH01178.1 - 0.0012 17.1 33.1 0.0012 17.1 33.1 4.6 1 1 4 5 5 5 2 HOOK protein Golgin_A5 PF09787.9 KOH01178.1 - 0.0056 16.2 28.2 0.0056 16.2 28.2 6.2 1 1 8 9 9 8 5 Golgin subfamily A member 5 TPR_MLP1_2 PF07926.12 KOH01178.1 - 0.0074 16.4 18.0 0.0074 16.4 18.0 8.3 1 1 8 9 9 9 5 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 KOH01178.1 - 0.023 13.6 150.7 0.027 13.4 23.4 7.0 1 1 7 8 8 8 0 Spc7 kinetochore protein COMP PF11598.8 KOH01178.1 - 0.077 13.5 0.4 0.077 13.5 0.4 5.1 5 0 0 5 5 5 0 Cartilage oligomeric matrix protein Lebercilin PF15619.6 KOH01178.1 - 0.28 10.8 160.7 0.026 14.2 27.0 6.9 2 2 4 6 6 4 0 Ciliary protein causing Leber congenital amaurosis disease ATG16 PF08614.11 KOH01178.1 - 0.43 10.8 141.2 1.9 8.7 11.3 7.8 1 1 6 7 7 7 0 Autophagy protein 16 (ATG16) PACT_coil_coil PF10495.9 KOH01178.1 - 0.54 10.9 0.0 0.54 10.9 0.0 4.3 5 2 0 5 5 2 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein Nup54_57_C PF18570.1 KOH01178.1 - 0.65 9.6 6.7 0.25 11.0 0.6 3.5 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain DUF4407 PF14362.6 KOH01178.1 - 2.4 7.5 96.6 1.9 7.7 13.3 5.5 1 1 4 5 5 5 0 Domain of unknown function (DUF4407) Nucleoporin_FG2 PF15967.5 KOH01178.1 - 2.9 6.3 11.4 0.031 12.8 1.3 2.6 3 1 0 4 4 4 0 Nucleoporin FG repeated region Fez1 PF06818.15 KOH01178.1 - 7.9 6.9 137.5 1.6 9.1 28.0 6.4 1 1 5 6 6 5 0 Fez1 Tropomyosin PF00261.20 KOH01178.1 - 9.4 5.5 143.1 0.011 15.1 30.1 7.3 1 1 6 7 7 4 0 Tropomyosin Syntaxin_2 PF14523.6 KOH01179.1 - 0.11 12.9 2.4 1.4 9.3 1.6 2.2 1 1 1 2 2 2 0 Syntaxin-like protein DASH_Dam1 PF08653.10 KOH01179.1 - 0.15 11.9 0.8 0.37 10.6 0.2 2.0 2 0 0 2 2 2 0 DASH complex subunit Dam1 MSA-2c PF12238.8 KOH01179.1 - 0.16 12.0 3.4 0.18 11.8 3.4 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c VHS PF00790.19 KOH01180.1 - 2.7e-48 163.4 0.0 7.8e-48 161.9 0.0 1.8 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 KOH01180.1 - 7e-18 64.7 2.0 7e-18 64.7 2.0 3.3 3 1 1 4 4 4 1 GAT domain Alpha_adaptinC2 PF02883.20 KOH01180.1 - 2.4e-17 63.2 0.2 7.8e-17 61.6 0.0 2.0 2 0 0 2 2 2 1 Adaptin C-terminal domain GGA_N-GAT PF18308.1 KOH01180.1 - 7.5e-09 35.1 1.6 3.8e-08 32.8 0.2 2.7 2 0 0 2 2 2 1 GGA N-GAT domain EcsC PF12787.7 KOH01180.1 - 0.064 12.9 0.0 0.22 11.2 0.0 1.9 1 1 1 2 2 2 0 EcsC protein family HSA PF07529.13 KOH01181.1 - 8.4e-16 58.1 0.1 8.4e-16 58.1 0.1 3.4 4 0 0 4 4 4 1 HSA Myb_DNA-bind_6 PF13921.6 KOH01181.1 - 4.9e-10 39.5 0.8 2.2e-09 37.4 0.8 2.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 KOH01181.1 - 0.00032 20.8 0.2 0.0013 18.8 0.2 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain BCIP PF13862.6 KOH01182.1 - 3.5e-49 167.4 0.3 3.5e-49 167.4 0.3 1.4 2 0 0 2 2 2 1 p21-C-terminal region-binding protein YL1 PF05764.13 KOH01183.1 - 0.038 14.1 12.7 0.058 13.5 12.7 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Macoilin PF09726.9 KOH01183.1 - 0.74 8.3 5.3 0.92 8.0 5.3 1.1 1 0 0 1 1 1 0 Macoilin family AT_hook PF02178.19 KOH01183.1 - 3.9 7.7 9.9 0.071 13.0 2.1 2.4 2 0 0 2 2 2 0 AT hook motif CDC45 PF02724.14 KOH01183.1 - 4.4 5.5 13.1 6.7 4.9 13.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Rad60-SLD PF11976.8 KOH01184.1 - 5.6e-25 87.0 3.1 9.7e-24 83.0 1.9 2.9 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Peptidase_S49_N PF08496.10 KOH01184.1 - 7.8 6.5 17.4 2.4 8.2 1.9 2.7 2 1 0 2 2 2 0 Peptidase family S49 N-terminal DSS1_SEM1 PF05160.13 KOH01185.1 - 1.1e-20 73.5 14.4 1.6e-20 72.9 14.4 1.3 1 0 0 1 1 1 1 DSS1/SEM1 family WD40 PF00400.32 KOH01186.1 - 1.1e-27 95.7 9.9 1.5e-06 28.8 0.0 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH01186.1 - 8.9e-06 25.9 0.0 2 8.7 0.0 4.1 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain NUC153 PF08159.12 KOH01187.1 - 4.3e-15 55.2 8.0 1.7e-14 53.3 0.9 2.9 3 0 0 3 3 3 2 NUC153 domain Kei1 PF08552.11 KOH01188.1 - 2.4e-48 164.6 8.3 2.8e-48 164.3 8.3 1.1 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 FHA PF00498.26 KOH01189.1 - 1.3e-05 25.4 1.7 2.2e-05 24.7 0.3 2.3 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 KOH01189.1 - 0.013 15.8 0.0 0.044 14.1 0.0 2.0 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain RAI1 PF08652.11 KOH01190.1 - 9.2e-05 22.6 0.0 0.00021 21.4 0.0 1.6 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Glyco_hydro_18 PF00704.28 KOH01191.1 - 4e-81 273.1 4.2 4.9e-81 272.8 4.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GPP34 PF05719.11 KOH01192.1 - 3.7e-65 219.8 0.0 4.5e-65 219.5 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Leucyl-specific PF14795.6 KOH01192.1 - 0.16 12.0 0.3 3.5 7.8 0.1 2.4 2 0 0 2 2 2 0 Leucine-tRNA synthetase-specific domain EF-hand_1 PF00036.32 KOH01193.1 - 3.6e-27 91.8 6.1 9.3e-08 31.1 0.3 4.5 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KOH01193.1 - 1.2e-24 84.1 5.1 2.2e-06 27.1 0.2 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 KOH01193.1 - 8.9e-24 83.7 7.0 1e-16 61.1 0.3 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KOH01193.1 - 4.6e-18 64.8 9.6 1.4e-08 34.5 0.2 3.7 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KOH01193.1 - 3.9e-17 60.9 4.2 2.8e-05 23.4 0.2 4.2 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.7 KOH01193.1 - 0.00014 21.8 4.1 1.6 8.7 0.1 3.5 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOH01193.1 - 0.00019 21.7 0.4 0.029 14.7 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOH01193.1 - 0.0004 20.7 1.0 0.045 14.1 0.3 2.9 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region S10_plectin PF03501.15 KOH01193.1 - 0.041 14.0 0.0 0.071 13.2 0.0 1.5 1 0 0 1 1 1 0 Plectin/S10 domain EF-hand_13 PF17958.1 KOH01193.1 - 0.057 13.2 0.0 1.9 8.4 0.0 3.0 4 1 0 4 4 4 0 EF-hand domain PHB_acc_N PF07879.11 KOH01193.1 - 0.11 12.5 0.1 8.6 6.5 0.1 2.6 2 0 0 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain YTH PF04146.15 KOH01194.1 - 1.5e-34 119.3 0.5 4.4e-34 117.8 0.5 1.8 1 0 0 1 1 1 1 YT521-B-like domain BCS1_N PF08740.11 KOH01196.1 - 5.4e-46 156.9 0.0 7.5e-46 156.5 0.0 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 KOH01196.1 - 1.7e-23 83.5 0.0 2.9e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KOH01196.1 - 0.00071 19.1 0.0 0.0095 15.5 0.0 2.4 3 0 0 3 3 2 1 P-loop containing dynein motor region RuvB_N PF05496.12 KOH01196.1 - 0.0011 18.7 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 KOH01196.1 - 0.0024 17.1 0.0 0.0039 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 KOH01196.1 - 0.0029 18.0 0.0 0.0089 16.4 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 KOH01196.1 - 0.0031 17.7 0.0 0.0076 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOH01196.1 - 0.0038 17.2 0.0 0.012 15.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KOH01196.1 - 0.0046 17.5 0.0 0.015 15.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 KOH01196.1 - 0.013 15.3 0.0 0.037 13.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KOH01196.1 - 0.013 16.0 0.0 0.029 14.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter TIP49 PF06068.13 KOH01196.1 - 0.018 14.3 0.0 1.3 8.2 0.0 2.3 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_29 PF13555.6 KOH01196.1 - 0.02 14.6 0.0 0.067 13.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain NACHT PF05729.12 KOH01196.1 - 0.02 14.8 0.0 0.32 10.9 0.0 2.7 2 1 1 3 3 3 0 NACHT domain RNA_helicase PF00910.22 KOH01196.1 - 0.028 14.8 0.0 0.087 13.2 0.0 1.9 1 0 0 1 1 1 0 RNA helicase ATPase PF06745.13 KOH01196.1 - 0.042 13.2 0.0 0.086 12.2 0.0 1.5 1 0 0 1 1 1 0 KaiC Rad17 PF03215.15 KOH01196.1 - 0.046 13.6 0.0 0.88 9.5 0.0 2.2 1 1 1 2 2 2 0 Rad17 P-loop domain AAA_21 PF13304.6 KOH01196.1 - 0.048 13.5 0.0 0.083 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 KOH01196.1 - 0.066 13.5 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain RcnB PF11776.8 KOH01196.1 - 0.069 13.2 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Nickel/cobalt transporter regulator AAA_11 PF13086.6 KOH01196.1 - 0.097 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 KOH01196.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Pyr_redox_2 PF07992.14 KOH01197.1 - 3e-06 26.7 0.0 7.3e-06 25.4 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOH01197.1 - 3.5e-05 24.0 0.0 7.3e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KOH01197.1 - 0.0017 18.4 0.0 0.0059 16.6 0.0 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 KOH01197.1 - 0.021 14.4 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 KOH01197.1 - 0.023 14.7 0.0 6.4 6.8 0.0 2.8 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 KOH01197.1 - 0.061 13.8 0.0 4.6 7.7 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding F1F0-ATPsyn_F PF10791.9 KOH01198.1 - 3e-41 139.8 0.1 3.4e-41 139.6 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.9 KOH01198.1 - 0.018 15.4 0.0 0.028 14.8 0.0 1.3 1 1 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f RhoGAP PF00620.27 KOH01199.1 - 6.3e-46 155.9 0.4 1.3e-45 154.9 0.4 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 KOH01199.1 - 4.3e-15 55.7 31.7 3.2e-10 40.1 8.1 2.6 2 0 0 2 2 2 2 LIM domain TMF_TATA_bd PF12325.8 KOH01199.1 - 0.00094 19.4 4.2 0.00094 19.4 4.2 2.4 3 0 0 3 3 3 1 TATA element modulatory factor 1 TATA binding Complex1_LYR PF05347.15 KOH01200.1 - 1.8e-12 47.1 0.1 2.1e-12 46.9 0.1 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) TPP_enzyme_N PF02776.18 KOH01201.1 - 3.6e-26 91.8 0.0 6e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 KOH01201.1 - 9e-20 70.8 0.0 1.5e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 KOH01201.1 - 1.1e-14 54.5 0.0 2.3e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Ribosomal_60s PF00428.19 KOH01202.1 - 6e-24 84.5 14.1 7.1e-24 84.2 14.1 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein TrmB PF01978.19 KOH01202.1 - 0.018 14.9 0.1 0.035 14.0 0.1 1.5 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB FTA4 PF13093.6 KOH01203.1 - 0.0033 17.3 1.4 0.0045 16.9 1.4 1.2 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Lipoprotein_6 PF01441.19 KOH01203.1 - 0.013 15.6 1.2 0.025 14.6 1.2 1.5 1 0 0 1 1 1 0 Lipoprotein Snapin_Pallidin PF14712.6 KOH01203.1 - 0.018 15.5 0.8 10 6.6 0.0 2.9 2 1 1 3 3 3 0 Snapin/Pallidin FadA PF09403.10 KOH01203.1 - 5.7 7.5 9.7 11 6.5 0.8 3.0 2 1 1 3 3 3 0 Adhesion protein FadA Gpr1_Fun34_YaaH PF01184.19 KOH01204.1 - 1.5e-71 240.3 14.6 1.9e-71 239.9 14.6 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family GTP_EFTU PF00009.27 KOH01205.1 - 1.6e-67 226.8 0.3 2.3e-67 226.3 0.3 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 KOH01205.1 - 9e-33 112.6 0.1 7.2e-32 109.7 0.0 2.3 1 1 1 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 KOH01205.1 - 6.7e-22 77.3 0.0 1.9e-21 75.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 KOH01205.1 - 1.7e-13 50.4 0.0 6.6e-13 48.6 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 KOH01205.1 - 2.9e-13 50.0 0.3 1e-12 48.3 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOH01205.1 - 0.00018 21.6 0.3 0.00036 20.6 0.3 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase ERCC4 PF02732.15 KOH01206.1 - 6.7e-22 78.4 1.7 1.1e-21 77.7 0.6 2.0 2 0 0 2 2 2 1 ERCC4 domain HHH_3 PF12836.7 KOH01206.1 - 0.038 14.2 0.2 0.15 12.4 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif Sugar_tr PF00083.24 KOH01207.1 - 1.1e-94 317.9 26.2 7.9e-53 179.9 4.1 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KOH01207.1 - 8e-23 80.9 33.3 1.6e-18 66.8 13.3 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_2 PF04550.12 KOH01207.1 - 1.2 9.8 8.2 0.85 10.2 4.3 2.6 2 0 0 2 2 2 0 Phage holin family 2 BAR PF03114.18 KOH01208.1 - 1.2e-65 221.5 7.8 1.5e-65 221.2 7.8 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 KOH01208.1 - 1.3e-14 53.5 0.0 2.2e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOH01208.1 - 4.4e-11 42.5 0.1 7.5e-11 41.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOH01208.1 - 6.1e-07 29.0 0.0 1.2e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF755 PF05501.11 KOH01208.1 - 6.1 7.1 8.0 0.49 10.7 2.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF755) RhoGAP PF00620.27 KOH01209.1 - 5.2e-32 110.8 0.4 5e-31 107.6 0.4 2.3 1 1 0 1 1 1 1 RhoGAP domain ThiF PF00899.21 KOH01210.1 - 1.4e-72 244.0 0.0 1.9e-72 243.6 0.0 1.1 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 KOH01210.1 - 7.4e-09 35.9 5.4 6.3e-05 23.0 0.8 2.5 1 1 1 2 2 2 2 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.20 KOH01210.1 - 0.016 15.3 0.0 0.048 13.7 0.0 1.8 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase UBA2_C PF16195.5 KOH01210.1 - 0.02 15.6 5.0 0.052 14.2 5.0 1.6 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus NAD_binding_7 PF13241.6 KOH01210.1 - 0.034 14.6 0.0 0.29 11.6 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding PagP PF07017.11 KOH01211.1 - 0.11 12.0 0.3 0.2 11.1 0.3 1.4 1 0 0 1 1 1 0 Antimicrobial peptide resistance and lipid A acylation protein PagP Acetyltransf_10 PF13673.7 KOH01211.1 - 0.12 12.4 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain TFIID-18kDa PF02269.16 KOH01212.1 - 1.6e-37 127.4 0.4 6e-37 125.5 0.1 2.1 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit FAM193_C PF15914.5 KOH01212.1 - 0.1 12.4 1.6 0.41 10.4 1.6 2.1 1 0 0 1 1 1 0 FAM193 family C-terminal Synaptobrevin PF00957.21 KOH01212.1 - 0.35 10.7 4.2 0.15 11.8 1.2 1.9 2 0 0 2 2 2 0 Synaptobrevin She9_MDM33 PF05546.11 KOH01213.1 - 4.6e-87 290.9 18.7 9e-87 290.0 11.3 2.2 2 0 0 2 2 2 2 She9 / Mdm33 family DUF2371 PF10177.9 KOH01213.1 - 0.1 12.7 0.0 0.3 11.3 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) PsbH PF00737.20 KOH01213.1 - 0.17 11.7 0.6 0.32 10.8 0.6 1.4 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein DUF4094 PF13334.6 KOH01213.1 - 0.73 10.3 8.2 7.1 7.1 0.3 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) Cep57_MT_bd PF06657.13 KOH01213.1 - 2.7 8.5 12.8 4.2 7.9 0.9 3.8 3 1 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Golgin_A5 PF09787.9 KOH01213.1 - 3.7 6.9 26.7 1.1 8.7 10.9 2.9 3 0 0 3 3 3 0 Golgin subfamily A member 5 AAA PF00004.29 KOH01214.1 - 2.1e-46 157.6 0.3 9.8e-46 155.5 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 KOH01214.1 - 8.5e-09 35.2 0.1 5.8e-08 32.6 0.0 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 KOH01214.1 - 3.2e-08 33.9 0.0 8.2e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KOH01214.1 - 9e-08 32.7 0.0 1.6e-05 25.4 0.0 3.1 2 1 0 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 KOH01214.1 - 4.3e-07 30.0 0.1 1.9e-06 27.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOH01214.1 - 3.5e-05 24.1 1.0 0.0047 17.2 0.0 2.7 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 KOH01214.1 - 0.00012 21.4 0.0 0.00021 20.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 KOH01214.1 - 0.00035 20.3 0.0 0.001 18.8 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 KOH01214.1 - 0.00038 20.4 0.2 0.0012 18.8 0.0 1.9 3 0 0 3 3 1 1 NTPase AAA_lid_3 PF17862.1 KOH01214.1 - 0.00045 20.0 0.2 0.0012 18.6 0.2 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_18 PF13238.6 KOH01214.1 - 0.00097 19.7 0.0 0.012 16.1 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 KOH01214.1 - 0.0012 18.6 0.0 0.0032 17.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 KOH01214.1 - 0.0016 18.4 0.0 0.0031 17.5 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 KOH01214.1 - 0.0023 18.3 0.0 0.0048 17.3 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_24 PF13479.6 KOH01214.1 - 0.0024 17.6 0.1 0.0068 16.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 KOH01214.1 - 0.0028 17.7 0.0 0.0073 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOH01214.1 - 0.0032 17.6 0.0 0.0094 16.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KOH01214.1 - 0.0032 17.0 0.0 0.029 13.9 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region TniB PF05621.11 KOH01214.1 - 0.0033 16.9 0.1 0.33 10.3 0.0 2.7 3 0 0 3 3 3 1 Bacterial TniB protein TIP49 PF06068.13 KOH01214.1 - 0.0043 16.3 0.0 0.0079 15.4 0.0 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_3 PF07726.11 KOH01214.1 - 0.0057 16.5 0.0 0.015 15.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KOH01214.1 - 0.0059 16.3 0.0 0.15 11.8 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 KOH01214.1 - 0.0069 15.8 0.1 0.019 14.4 0.0 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 KOH01214.1 - 0.011 15.7 0.1 0.082 12.8 0.0 2.3 1 1 1 2 2 2 0 NACHT domain AAA_11 PF13086.6 KOH01214.1 - 0.012 15.4 0.1 0.12 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 KOH01214.1 - 0.017 15.4 0.0 0.042 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 KOH01214.1 - 0.022 14.7 0.7 0.28 11.1 0.0 2.6 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 KOH01214.1 - 0.027 14.2 0.0 0.068 12.9 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AFG1_ATPase PF03969.16 KOH01214.1 - 0.064 12.1 0.1 0.19 10.6 0.0 1.8 2 0 0 2 2 2 0 AFG1-like ATPase AAA_19 PF13245.6 KOH01214.1 - 0.1 12.9 0.1 0.31 11.4 0.1 1.8 2 0 0 2 2 1 0 AAA domain AAA_25 PF13481.6 KOH01214.1 - 0.12 11.9 1.5 0.5 9.9 0.1 2.4 2 1 0 3 3 3 0 AAA domain ABC_tran PF00005.27 KOH01214.1 - 0.12 12.8 0.2 0.41 11.1 0.0 2.2 2 1 0 2 2 2 0 ABC transporter DnaB_C PF03796.15 KOH01214.1 - 0.43 9.9 3.6 1.8 7.8 0.3 2.7 2 1 0 3 3 3 0 DnaB-like helicase C terminal domain AAA_23 PF13476.6 KOH01214.1 - 0.47 10.9 3.7 18 5.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain IBN_N PF03810.19 KOH01215.1 - 2.1e-20 72.4 0.3 6.5e-20 70.8 0.3 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain Telomerase_RBD PF12009.8 KOH01215.1 - 0.027 14.6 0.3 0.24 11.5 0.0 2.5 2 0 0 2 2 2 0 Telomerase ribonucleoprotein complex - RNA binding domain Arm_vescicular PF18770.1 KOH01215.1 - 0.17 11.8 0.2 0.47 10.4 0.2 1.7 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor CBFD_NFYB_HMF PF00808.23 KOH01216.1 - 5.2e-09 36.3 0.7 7.4e-09 35.8 0.7 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Utp12 PF04003.12 KOH01217.1 - 1.9e-23 82.8 1.3 3.1e-23 82.1 1.3 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 KOH01217.1 - 0.044 14.1 0.4 1.9 8.8 0.0 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Mlh1_C PF16413.5 KOH01217.1 - 0.1 11.9 0.3 8.2 5.7 0.1 2.3 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus BBS2_Mid PF14783.6 KOH01217.1 - 0.13 12.3 0.2 70 3.5 0.0 3.4 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 KOH01217.1 - 0.2 12.6 0.6 14 6.7 0.0 3.5 4 0 0 4 4 4 0 WD domain, G-beta repeat Pribosyltran PF00156.27 KOH01218.1 - 5.6e-09 35.7 0.0 8.7e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Fe-ADH PF00465.19 KOH01218.1 - 0.089 11.6 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase 3Beta_HSD PF01073.19 KOH01218.1 - 0.11 11.5 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family IU_nuc_hydro PF01156.19 KOH01219.1 - 2.4e-71 240.8 0.0 2.8e-71 240.6 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase p450 PF00067.22 KOH01220.1 - 8.4e-55 186.3 0.0 1.1e-54 186.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DIT1_PvcA PF05141.12 KOH01221.1 - 8.8e-101 337.0 0.0 1.1e-100 336.6 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein BssC_TutF PF08201.11 KOH01221.1 - 0.021 14.9 0.1 0.06 13.3 0.1 1.7 1 0 0 1 1 1 0 BssC/TutF protein S1 PF00575.23 KOH01222.1 - 4.6e-18 65.3 0.1 6.7e-18 64.8 0.1 1.2 1 0 0 1 1 1 1 S1 RNA binding domain SHS2_Rpb7-N PF03876.17 KOH01222.1 - 1.2e-16 60.8 0.0 2.6e-16 59.8 0.0 1.6 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.12 KOH01222.1 - 6.9e-06 26.3 0.0 1.3e-05 25.5 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 Ribosomal_L23 PF00276.20 KOH01223.1 - 6.8e-12 45.6 0.0 1.3e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 TRAPPC9-Trs120 PF08626.11 KOH01225.1 - 0 1043.5 31.2 0 1043.3 31.2 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit PINIT PF14324.6 KOH01226.1 - 4.4e-33 114.7 0.0 4.4e-33 114.7 0.0 2.3 2 0 0 2 2 2 1 PINIT domain zf-MIZ PF02891.20 KOH01226.1 - 1.7e-21 75.7 6.6 2.8e-21 75.0 6.6 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.27 KOH01226.1 - 2.1e-08 33.7 0.0 4.5e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 SAP domain zf-Nse PF11789.8 KOH01226.1 - 0.00013 21.7 1.1 0.00031 20.5 1.1 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 KOH01226.1 - 0.097 12.5 4.2 0.2 11.6 4.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOH01226.1 - 0.13 12.3 3.5 0.29 11.2 3.5 1.7 1 0 0 1 1 1 0 RING-type zinc-finger THEG4 PF15834.5 KOH01226.1 - 1.1 9.2 4.9 0.31 11.0 0.6 2.3 2 1 1 3 3 3 0 Testis highly expressed protein 4 zf-C3HC4_4 PF15227.6 KOH01226.1 - 2.5 8.3 3.8 4.6 7.5 3.8 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KOH01226.1 - 2.6 8.5 4.0 4.7 7.6 4.0 1.4 1 0 0 1 1 1 0 Ring finger domain ICMT PF04140.14 KOH01227.1 - 7.9e-31 106.3 0.7 1.5e-30 105.4 0.7 1.5 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 KOH01227.1 - 1.4e-13 51.1 0.9 2.7e-13 50.2 0.9 1.5 1 0 0 1 1 1 1 Phospholipid methyltransferase DUF1295 PF06966.12 KOH01227.1 - 6.4e-07 29.1 0.4 7.7e-07 28.9 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.11 KOH01227.1 - 0.00065 19.3 0.5 0.00079 19.0 0.5 1.2 1 0 0 1 1 1 1 NnrU protein DER1 PF04511.15 KOH01228.1 - 3.8e-61 206.3 11.8 4.5e-61 206.1 11.8 1.1 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 KOH01228.1 - 0.42 10.6 8.9 1.6 8.7 8.9 1.9 1 1 0 1 1 1 0 Rhomboid family Nop25 PF09805.9 KOH01229.1 - 9.3e-38 129.8 17.6 9.3e-38 129.8 17.6 2.0 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) RyR PF02026.16 KOH01229.1 - 7 6.9 8.1 0.38 11.0 1.0 2.3 2 1 1 3 3 3 0 RyR domain EXS PF03124.14 KOH01230.1 - 2.4e-53 181.6 29.5 2.7e-53 181.4 29.5 1.0 1 0 0 1 1 1 1 EXS family Peptidase_M28 PF04389.17 KOH01231.1 - 1.2e-27 96.9 0.0 2.6e-27 95.8 0.0 1.6 1 1 1 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 KOH01231.1 - 3.6e-06 26.8 0.0 5.2e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 TPR_14 PF13428.6 KOH01232.1 - 4.2e-07 30.2 3.0 1.2 10.2 0.0 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat NRDE-2 PF08424.10 KOH01232.1 - 0.00018 20.8 8.5 0.1 11.7 2.8 4.8 3 2 1 4 4 4 2 NRDE-2, necessary for RNA interference Suf PF05843.14 KOH01232.1 - 0.00018 21.6 3.8 0.65 9.9 0.1 4.1 4 0 0 4 4 4 2 Suppressor of forked protein (Suf) DUF1688 PF07958.11 KOH01232.1 - 0.023 13.4 0.0 0.044 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1688) TPR_2 PF07719.17 KOH01232.1 - 0.04 14.0 0.7 60 4.1 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOH01232.1 - 0.11 12.4 0.2 0.59 10.1 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KOH01232.1 - 0.11 12.5 12.2 11 6.0 0.1 6.2 6 2 1 7 7 7 0 Mad3/BUB1 homology region 1 Ribosomal_L11_N PF03946.14 KOH01233.1 - 2.5e-21 75.2 0.3 4.6e-21 74.4 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 KOH01233.1 - 4.2e-17 62.4 0.9 9.4e-17 61.3 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain NusA_N PF08529.11 KOH01233.1 - 0.097 13.0 0.9 0.15 12.4 0.9 1.3 1 1 0 1 1 1 0 NusA N-terminal domain IMS PF00817.20 KOH01234.1 - 1.2e-46 158.4 0.0 2.7e-46 157.3 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family zf_UBZ PF18439.1 KOH01234.1 - 1.7e-08 33.9 1.0 5.8e-08 32.2 1.0 1.9 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_C PF11799.8 KOH01234.1 - 2.6e-07 31.3 0.0 6.9e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 KOH01234.1 - 0.00049 20.3 0.0 0.001 19.2 0.0 1.6 1 0 0 1 1 1 1 IMS family HHH motif zf-C2H2_jaz PF12171.8 KOH01234.1 - 0.078 13.3 0.4 0.22 11.8 0.4 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KOH01234.1 - 0.3 12.0 1.0 1 10.4 0.4 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger Zn_clus PF00172.18 KOH01236.1 - 4.8e-07 29.8 8.5 1.2e-06 28.6 8.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AMPKBI PF04739.15 KOH01237.1 - 6.4e-20 71.2 0.0 6.4e-20 71.2 0.0 3.9 4 1 0 4 4 4 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 KOH01237.1 - 9.3e-07 29.0 0.0 3.1e-06 27.3 0.0 1.9 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase PDDEXK_6 PF04720.12 KOH01237.1 - 8 6.3 10.2 8.5 6.2 8.4 2.0 1 1 0 1 1 1 0 PDDEXK-like family of unknown function PX PF00787.24 KOH01238.1 - 5.2e-18 65.1 0.2 4.3e-17 62.1 0.0 2.6 2 0 0 2 2 2 1 PX domain zf-RING_9 PF13901.6 KOH01238.1 - 0.017 15.1 1.1 0.017 15.1 1.1 2.8 3 0 0 3 3 3 0 Putative zinc-RING and/or ribbon Rpn9_C PF18261.1 KOH01239.1 - 7e-18 63.9 1.7 1.5e-17 62.9 1.7 1.6 1 0 0 1 1 1 1 Rpn9 C-terminal helix PCI PF01399.27 KOH01239.1 - 2.4e-13 50.5 0.3 2.4e-13 50.5 0.3 2.4 3 1 1 4 4 4 1 PCI domain RE_Alw26IDE PF09665.10 KOH01239.1 - 0.21 10.7 2.7 0.36 9.9 2.7 1.3 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) Abhydrolase_3 PF07859.13 KOH01240.1 - 9.7e-08 32.1 0.0 1.1e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 KOH01240.1 - 1.7e-05 23.9 0.0 2.5e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 KOH01240.1 - 0.0016 17.7 0.0 1.3 8.2 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 UPF0565 PF10561.9 KOH01240.1 - 0.013 14.7 0.2 0.027 13.7 0.1 1.5 1 1 0 1 1 1 0 Uncharacterised protein family UPF0565 LIDHydrolase PF10230.9 KOH01240.1 - 0.014 14.9 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Abhydrolase_1 PF00561.20 KOH01240.1 - 0.042 13.5 0.0 0.065 12.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 KOH01240.1 - 0.093 12.6 0.1 0.37 10.6 0.0 2.1 1 1 1 2 2 2 0 Lipase (class 3) N_Asn_amidohyd PF14736.6 KOH01240.1 - 0.12 11.5 0.3 0.23 10.6 0.0 1.5 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase DUF900 PF05990.12 KOH01240.1 - 0.13 11.7 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) eIF3g PF12353.8 KOH01241.1 - 5.8e-37 126.9 0.4 8.9e-37 126.3 0.4 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 KOH01241.1 - 4.8e-11 42.3 0.0 7.6e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 KOH01241.1 - 0.029 14.6 1.3 0.28 11.4 0.0 2.3 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter zf-CCCH_7 PF18586.1 KOH01241.1 - 0.042 14.2 1.3 0.19 12.1 0.1 2.4 3 0 0 3 3 3 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 M16C_assoc PF08367.11 KOH01242.1 - 1.4e-72 243.9 0.2 2.3e-72 243.2 0.2 1.4 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 KOH01242.1 - 4.7e-34 118.0 0.2 5.2e-19 69.0 0.0 3.1 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOH01242.1 - 3.1e-05 24.0 0.0 7.6e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) SurA_N_3 PF13624.6 KOH01242.1 - 0.45 10.3 2.4 0.76 9.6 1.0 2.0 2 0 0 2 2 2 0 SurA N-terminal domain RRM_1 PF00076.22 KOH01243.1 - 3.9e-30 103.5 0.1 1.8e-17 62.9 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOH01243.1 - 0.0012 18.7 0.0 0.031 14.1 0.0 2.1 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_5 PF13893.6 KOH01243.1 - 0.016 14.8 0.0 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOH01243.1 - 0.053 13.7 0.1 0.47 10.6 0.1 2.2 1 1 0 1 1 1 0 RNA recognition motif PRCC PF10253.9 KOH01243.1 - 0.13 13.1 12.4 0.19 12.5 12.4 1.4 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting RRM_9 PF18444.1 KOH01243.1 - 0.24 11.3 0.0 8.5 6.3 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif PIG-S PF10510.9 KOH01244.1 - 4.8e-132 441.4 5.1 5.6e-132 441.2 5.1 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein LCM PF04072.14 KOH01245.1 - 7.4e-29 101.0 0.0 9.3e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Metallophos PF00149.28 KOH01246.1 - 3.4e-35 122.4 0.1 5.9e-35 121.6 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KOH01246.1 - 1.1e-19 70.6 0.3 2.5e-19 69.5 0.3 1.7 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain PIG-P PF08510.12 KOH01247.1 - 1.2e-30 105.9 1.4 1.5e-30 105.6 1.4 1.1 1 0 0 1 1 1 1 PIG-P V_ATPase_I PF01496.19 KOH01247.1 - 0.0083 14.1 0.0 0.0096 13.9 0.0 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF4131 PF13567.6 KOH01247.1 - 0.053 13.2 0.1 0.067 12.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) EamA PF00892.20 KOH01248.1 - 7e-10 39.2 37.9 3.3e-06 27.3 7.7 3.1 3 0 0 3 3 3 3 EamA-like transporter family LRS4 PF10422.9 KOH01249.1 - 2.5e-56 191.0 24.6 2.5e-56 191.0 24.6 2.0 2 0 0 2 2 2 1 Monopolin complex subunit LRS4 DOT1 PF08123.13 KOH01250.1 - 5.8e-92 306.8 0.6 1.2e-91 305.8 0.6 1.6 1 0 0 1 1 1 1 Histone methylation protein DOT1 GTP-bdg_N PF13167.6 KOH01250.1 - 0.012 16.2 2.2 1.9 9.3 0.3 2.7 2 0 0 2 2 2 0 GTP-binding GTPase N-terminal CMAS PF02353.20 KOH01250.1 - 0.033 13.5 0.0 0.09 12.1 0.0 1.7 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Pribosyltran PF00156.27 KOH01251.1 - 1.2e-13 50.9 0.0 1.6e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KOH01251.1 - 0.00035 20.1 0.1 0.00055 19.4 0.1 1.5 1 1 0 1 1 1 1 Uracil phosphoribosyltransferase Med13_N PF11597.8 KOH01252.1 - 9.4e-62 209.2 0.7 9.4e-62 209.2 0.7 1.9 2 0 0 2 2 2 1 Mediator complex subunit 13 N-terminal Med13_C PF06333.12 KOH01252.1 - 7e-20 71.6 0.2 3.8e-15 56.0 0.6 4.5 3 2 3 6 6 6 2 Mediator complex subunit 13 C-terminal domain Spt20 PF12090.8 KOH01252.1 - 1.8e-06 27.8 8.2 1.8e-06 27.8 8.2 2.1 2 1 0 2 2 2 1 Spt20 family Eapp_C PF10238.9 KOH01252.1 - 0.011 15.8 0.2 0.011 15.8 0.2 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein TFIIA PF03153.13 KOH01252.1 - 0.033 14.2 32.4 0.026 14.5 13.6 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Androgen_recep PF02166.16 KOH01252.1 - 2.8 6.7 18.1 4.9 5.9 18.1 1.3 1 0 0 1 1 1 0 Androgen receptor DUF676 PF05057.14 KOH01253.1 - 1.1e-60 204.8 0.0 1.8e-60 204.2 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 KOH01253.1 - 5e-05 23.2 0.0 0.00012 22.0 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) DUF915 PF06028.11 KOH01253.1 - 0.0018 17.6 0.0 0.0038 16.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_1 PF00561.20 KOH01253.1 - 0.2 11.3 0.1 0.81 9.3 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold ECM11 PF15463.6 KOH01254.1 - 2.7e-17 63.6 1.2 2.7e-17 63.6 1.2 2.1 2 1 0 2 2 2 1 Extracellular mutant protein 11 CREPT PF16566.5 KOH01254.1 - 0.059 13.5 0.3 0.059 13.5 0.3 2.3 2 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Remorin_N PF03766.13 KOH01254.1 - 3.2 7.9 8.2 1.9 8.6 1.2 2.8 2 0 0 2 2 2 0 Remorin, N-terminal region Ribosomal_S17e PF00833.18 KOH01255.1 - 2.8e-41 140.3 0.1 3.3e-41 140.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal S17 ZZ PF00569.17 KOH01256.1 - 2e-17 62.7 8.6 3.6e-17 61.9 8.6 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 KOH01256.1 - 5e-11 42.6 0.4 1.8e-10 40.9 0.1 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain SWIRM PF04433.17 KOH01256.1 - 1.7e-08 34.6 0.3 8.4e-07 29.2 0.0 2.9 3 0 0 3 3 3 1 SWIRM domain Myb_DNA-bind_6 PF13921.6 KOH01256.1 - 2.1e-05 24.7 0.0 7.4e-05 22.9 0.0 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain U3_assoc_6 PF08640.11 KOH01257.1 - 3.4e-33 113.6 5.1 1.6e-31 108.2 0.8 2.9 2 1 0 2 2 2 2 U3 small nucleolar RNA-associated protein 6 NRDE-2 PF08424.10 KOH01257.1 - 8.8e-05 21.8 3.9 0.0054 15.9 1.0 2.7 1 1 1 2 2 2 2 NRDE-2, necessary for RNA interference Suf PF05843.14 KOH01257.1 - 0.0013 18.8 8.9 0.006 16.6 0.8 3.9 3 1 2 5 5 5 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 KOH01257.1 - 0.0018 19.0 0.0 1.5 9.9 0.0 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOH01257.1 - 0.007 16.7 1.6 4.2 8.0 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF2250 PF10007.9 KOH01257.1 - 0.069 13.3 4.5 0.55 10.4 0.0 3.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2250) HAT PF02184.16 KOH01257.1 - 0.13 12.3 0.3 0.64 10.0 0.0 2.2 2 0 0 2 2 2 0 HAT (Half-A-TPR) repeat Ribosomal_S13 PF00416.22 KOH01258.1 - 5.8e-57 191.6 3.0 6.7e-57 191.4 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 KOH01258.1 - 0.0034 16.2 0.0 0.0036 16.1 0.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) CDPS PF16715.5 KOH01258.1 - 0.045 13.4 0.1 0.045 13.4 0.1 1.1 1 0 0 1 1 1 0 Cyclodipeptide synthase Homeodomain PF00046.29 KOH01259.1 - 1.8e-18 66.1 2.2 3.9e-18 65.1 2.2 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KOH01259.1 - 1.6e-05 24.7 0.5 0.00012 21.9 0.1 2.3 2 0 0 2 2 2 1 Homeobox KN domain Metallophos PF00149.28 KOH01260.1 - 9.9e-07 29.5 2.1 1e-06 29.4 0.5 1.9 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase EIIBC-GUT_N PF03612.14 KOH01260.1 - 0.17 11.6 0.9 0.34 10.6 0.9 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus LZ_Tnp_IS66 PF13007.7 KOH01260.1 - 0.69 10.7 3.1 6.9 7.5 0.8 2.6 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain Peptidase_S49_N PF08496.10 KOH01260.1 - 1.4 9.0 6.2 1.8 8.6 4.5 1.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4604 PF15377.6 KOH01260.1 - 5.5 7.4 17.5 1.6 9.1 11.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) AhpC-TSA PF00578.21 KOH01261.1 - 1.9e-34 118.2 0.0 1.1e-33 115.7 0.0 1.8 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 KOH01261.1 - 1.6e-17 63.6 0.0 3.7e-17 62.4 0.0 1.5 2 0 0 2 2 2 1 Redoxin 1-cysPrx_C PF10417.9 KOH01261.1 - 1.1e-08 34.7 0.2 2.2e-08 33.8 0.2 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 KOH01261.1 - 0.0094 15.9 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC Guanylate_kin PF00625.21 KOH01262.1 - 5.8e-68 228.2 0.0 6.4e-68 228.0 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase MMR_HSR1 PF01926.23 KOH01262.1 - 1e-07 32.0 0.1 2e-07 31.1 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KOH01262.1 - 6.2e-07 29.9 0.0 1.2e-06 29.0 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 KOH01262.1 - 6.7e-05 23.1 0.0 0.00029 21.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOH01262.1 - 0.00012 22.3 0.0 0.00027 21.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOH01262.1 - 0.00031 21.3 1.1 0.0037 17.8 1.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOH01262.1 - 0.00088 19.5 0.1 0.0019 18.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOH01262.1 - 0.00093 19.0 0.0 0.0016 18.2 0.0 1.5 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.6 KOH01262.1 - 0.00097 18.9 0.1 0.006 16.3 0.1 2.1 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 KOH01262.1 - 0.001 19.6 0.1 0.0014 19.2 0.1 1.5 1 1 0 1 1 1 1 ABC transporter AAA_14 PF13173.6 KOH01262.1 - 0.0024 17.9 0.0 0.0057 16.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KOH01262.1 - 0.0031 17.9 0.0 0.0077 16.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA PF00004.29 KOH01262.1 - 0.004 17.6 0.4 0.017 15.6 0.1 2.0 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 KOH01262.1 - 0.0043 17.0 0.0 0.0072 16.2 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 KOH01262.1 - 0.0051 16.5 1.5 0.02 14.6 0.1 2.2 2 1 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.12 KOH01262.1 - 0.0057 16.6 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 KOH01262.1 - 0.0062 16.9 0.0 0.3 11.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 KOH01262.1 - 0.0066 15.7 0.0 0.026 13.8 0.0 1.9 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 KOH01262.1 - 0.0072 15.9 0.2 0.015 14.8 0.0 1.6 2 0 0 2 2 2 1 P-loop containing dynein motor region NTPase_1 PF03266.15 KOH01262.1 - 0.01 15.7 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 0 NTPase SRPRB PF09439.10 KOH01262.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit T2SSE PF00437.20 KOH01262.1 - 0.013 14.6 0.0 0.026 13.6 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Rad17 PF03215.15 KOH01262.1 - 0.019 14.9 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain Viral_helicase1 PF01443.18 KOH01262.1 - 0.03 14.1 0.0 0.086 12.6 0.0 1.7 1 1 1 2 2 2 0 Viral (Superfamily 1) RNA helicase MobB PF03205.14 KOH01262.1 - 0.038 13.9 0.2 0.25 11.2 0.0 2.4 3 1 1 4 4 3 0 Molybdopterin guanine dinucleotide synthesis protein B KRTDAP PF15200.6 KOH01262.1 - 0.042 13.6 0.0 0.079 12.7 0.0 1.5 1 0 0 1 1 1 0 Keratinocyte differentiation-associated dNK PF01712.19 KOH01262.1 - 0.045 13.6 0.1 0.7 9.7 0.1 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase ATPase_2 PF01637.18 KOH01262.1 - 0.045 13.7 0.3 0.075 12.9 0.0 1.7 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea FeoB_N PF02421.18 KOH01262.1 - 0.051 13.1 0.3 5 6.6 0.0 2.1 1 1 1 2 2 2 0 Ferrous iron transport protein B cobW PF02492.19 KOH01262.1 - 0.065 12.8 0.0 0.18 11.4 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Cytidylate_kin PF02224.18 KOH01262.1 - 0.088 12.5 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase Adeno_IVa2 PF02456.15 KOH01262.1 - 0.09 11.6 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_5 PF07728.14 KOH01262.1 - 0.12 12.4 0.1 0.43 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Septin PF00735.18 KOH01262.1 - 0.12 11.6 0.0 0.23 10.7 0.0 1.5 1 1 0 1 1 1 0 Septin KAP_NTPase PF07693.14 KOH01262.1 - 0.12 11.5 0.0 0.13 11.5 0.0 1.3 1 1 0 1 1 1 0 KAP family P-loop domain Roc PF08477.13 KOH01262.1 - 0.13 12.5 0.0 1.4 9.1 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_17 PF13207.6 KOH01262.1 - 0.13 12.7 0.1 0.3 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KOH01262.1 - 0.16 12.5 3.0 0.38 11.2 3.0 1.9 1 1 0 1 1 1 0 AAA domain Na_H_Exchanger PF00999.21 KOH01263.1 - 8.6e-71 238.7 36.3 1.2e-70 238.3 36.3 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Myc_target_1 PF15179.6 KOH01263.1 - 0.14 12.0 4.1 0.18 11.7 1.2 2.4 2 0 0 2 2 2 0 Myc target protein 1 Wzy_C PF04932.15 KOH01263.1 - 4.8 6.8 0.0 4.8 6.8 0.0 4.0 3 2 0 3 3 3 0 O-Antigen ligase HECT PF00632.25 KOH01264.1 - 1.6e-88 297.1 1.8 4.5e-88 295.7 0.0 2.6 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.12 KOH01264.1 - 1.3e-58 199.1 0.4 3.7e-56 191.1 0.4 2.8 1 1 0 1 1 1 1 Domain of Unknown Function (DUF908) DUF913 PF06025.12 KOH01264.1 - 8.4e-52 176.4 6.5 1.5e-51 175.5 0.0 4.1 5 0 0 5 5 5 1 Domain of Unknown Function (DUF913) UBM PF14377.6 KOH01264.1 - 3.4e-13 48.5 4.8 2.2e-08 33.2 0.2 2.8 2 0 0 2 2 2 2 Ubiquitin binding region MSC PF09402.10 KOH01265.1 - 1.7e-88 297.4 3.2 1.7e-88 297.4 3.2 2.1 2 0 0 2 2 2 1 Man1-Src1p-C-terminal domain HeH PF12949.7 KOH01265.1 - 2e-16 59.4 3.2 3.1e-16 58.8 0.2 2.4 2 0 0 2 2 2 1 HeH/LEM domain Presenilin PF01080.17 KOH01265.1 - 3.5 6.3 14.6 22 3.6 0.0 2.2 2 0 0 2 2 2 0 Presenilin DHHC PF01529.20 KOH01266.1 - 4.4e-27 94.8 1.4 4.4e-27 94.8 1.4 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase UL41A PF17591.2 KOH01266.1 - 0.59 10.3 4.1 0.73 10.0 2.6 1.9 2 0 0 2 2 2 0 Herpesvirus UL41A MAT1 PF06391.13 KOH01267.1 - 4.9e-66 222.5 27.3 6.2e-66 222.1 27.3 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 KOH01267.1 - 1.2e-27 95.5 7.4 1.2e-27 95.5 7.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOH01267.1 - 0.00011 21.9 3.5 0.00027 20.7 3.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOH01267.1 - 0.00031 21.0 5.8 0.00055 20.2 5.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KOH01267.1 - 0.00033 20.4 5.6 0.00066 19.5 5.6 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOH01267.1 - 0.006 16.4 5.0 0.027 14.3 5.1 2.0 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOH01267.1 - 0.016 15.2 6.3 0.032 14.3 6.3 1.5 1 0 0 1 1 1 0 RING-type zinc-finger FliS PF02561.14 KOH01267.1 - 0.041 14.2 1.0 0.041 14.2 1.0 2.2 1 1 1 2 2 2 0 Flagellar protein FliS zf-RING_5 PF14634.6 KOH01267.1 - 0.051 13.5 8.5 0.75 9.8 8.8 2.2 1 1 1 2 2 2 0 zinc-RING finger domain Zn_ribbon_17 PF17120.5 KOH01267.1 - 0.053 13.1 1.2 0.11 12.2 1.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Perilipin PF03036.16 KOH01267.1 - 0.055 12.5 4.8 0.076 12.0 4.8 1.1 1 0 0 1 1 1 0 Perilipin family FlpD PF02662.16 KOH01267.1 - 0.41 10.7 5.3 7.2 6.6 2.3 2.6 2 0 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit zf-RING_4 PF14570.6 KOH01267.1 - 0.8 9.5 9.6 9.9 6.0 9.6 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 KOH01267.1 - 0.96 9.4 8.2 3.3 7.7 2.6 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Exonuc_VII_L PF02601.15 KOH01267.1 - 1.5 8.4 6.1 2 7.9 6.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mitovir_RNA_pol PF05919.11 KOH01267.1 - 2 7.5 7.2 2.6 7.1 7.2 1.1 1 0 0 1 1 1 0 Mitovirus RNA-dependent RNA polymerase Tweety PF04906.13 KOH01267.1 - 2.2 6.9 4.2 0.76 8.4 0.5 1.9 1 1 1 2 2 2 0 Tweety DUF3797 PF12677.7 KOH01267.1 - 4.1 7.4 6.2 2.2 8.2 2.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) Com_YlbF PF06133.11 KOH01267.1 - 4.2 8.0 21.9 5.4 7.7 14.2 3.0 2 1 1 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA DUF5539 PF17693.1 KOH01268.1 - 0.011 15.4 0.5 0.012 15.3 0.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5539) TMEM52 PF14979.6 KOH01268.1 - 0.19 11.6 0.4 0.21 11.5 0.4 1.1 1 0 0 1 1 1 0 Transmembrane 52 MRP-L28 PF09812.9 KOH01269.1 - 1.7e-36 125.8 3.7 2.1e-36 125.5 3.7 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 zf-C2H2 PF00096.26 KOH01270.1 - 0.0011 19.3 2.5 0.0011 19.3 2.5 4.0 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOH01270.1 - 0.0059 17.3 15.5 0.011 16.6 1.0 4.3 3 1 0 3 3 3 1 C2H2-type zinc finger DUF3327 PF11806.8 KOH01270.1 - 0.081 13.6 0.1 0.2 12.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3327) CpXC PF14353.6 KOH01270.1 - 0.095 12.8 0.1 2.4 8.2 0.0 2.7 2 0 0 2 2 2 0 CpXC protein zf-C2HE PF16278.5 KOH01270.1 - 0.25 11.8 1.9 2.8 8.4 0.0 3.2 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_2 PF13465.6 KOH01270.1 - 1.2 9.7 12.3 0.092 13.2 1.7 3.5 3 0 0 3 3 3 0 Zinc-finger double domain DUF3020 PF11223.8 KOH01271.1 - 8.9e-16 58.1 8.5 8.9e-16 58.1 8.5 7.0 6 0 0 6 6 6 2 Protein of unknown function (DUF3020) Methyltransf_11 PF08241.12 KOH01272.1 - 0.11 13.2 0.0 0.28 11.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain PAS_4 PF08448.10 KOH01272.1 - 0.13 12.6 0.0 0.44 10.8 0.0 2.1 1 1 0 1 1 1 0 PAS fold Pkinase PF00069.25 KOH01273.1 - 2e-63 214.3 0.0 3.1e-63 213.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH01273.1 - 3.8e-28 98.5 0.0 1.1e-27 97.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOH01273.1 - 1.4e-06 27.9 0.0 3.8e-06 26.4 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KOH01273.1 - 0.00082 18.4 0.1 0.002 17.1 0.1 1.6 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KOH01273.1 - 0.0012 18.9 0.1 0.0018 18.2 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 KOH01273.1 - 0.0079 15.8 0.4 2 8.0 0.1 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 PIP49_C PF12260.8 KOH01273.1 - 0.021 14.5 0.0 0.052 13.2 0.0 1.6 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 RIO1 PF01163.22 KOH01273.1 - 0.11 12.0 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 KOH01273.1 - 0.15 11.3 0.1 0.28 10.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOH01273.1 - 0.32 9.7 1.8 0.33 9.7 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase SNARE PF05739.19 KOH01274.1 - 8.9e-06 25.6 0.4 2.9e-05 24.0 0.4 1.9 1 0 0 1 1 1 1 SNARE domain Syntaxin-6_N PF09177.11 KOH01274.1 - 0.0056 17.2 6.9 0.019 15.5 5.4 2.6 1 1 0 1 1 1 1 Syntaxin 6, N-terminal Use1 PF09753.9 KOH01274.1 - 0.034 13.9 3.3 0.051 13.3 3.3 1.4 1 1 0 1 1 1 0 Membrane fusion protein Use1 NBD_C PF17042.5 KOH01274.1 - 0.044 14.3 0.8 0.092 13.3 0.7 1.5 2 0 0 2 2 2 0 Nucleotide-binding C-terminal domain Sec20 PF03908.13 KOH01274.1 - 0.044 13.7 1.9 0.22 11.5 0.0 2.6 2 1 1 3 3 3 0 Sec20 FokI_C PF02980.16 KOH01274.1 - 0.049 13.6 0.9 0.13 12.3 0.1 1.9 2 0 0 2 2 2 0 Restriction endonuclease FokI, catalytic domain DUF4848 PF16140.5 KOH01274.1 - 0.059 12.9 0.6 0.059 12.9 0.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4848) DUF1043 PF06295.12 KOH01274.1 - 0.06 13.4 0.4 0.06 13.4 0.4 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1043) RmuC PF02646.16 KOH01274.1 - 0.081 12.0 5.2 0.57 9.3 0.3 2.3 2 0 0 2 2 2 0 RmuC family DUF2207 PF09972.9 KOH01274.1 - 0.084 11.6 1.1 0.27 9.9 1.1 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) ATG16 PF08614.11 KOH01274.1 - 0.084 13.1 4.7 0.071 13.3 2.2 1.9 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 KOH01274.1 - 0.2 10.5 9.5 0.41 9.5 3.2 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Hrs_helical PF12210.8 KOH01274.1 - 0.46 11.1 8.6 0.58 10.7 2.0 2.8 2 1 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Phage_GPO PF05929.11 KOH01274.1 - 0.91 9.1 6.0 0.3 10.7 2.1 1.8 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase YabA PF06156.13 KOH01274.1 - 1.2 9.8 5.8 18 6.0 0.4 2.7 2 1 1 3 3 2 0 Initiation control protein YabA CagY_I PF14585.6 KOH01274.1 - 1.8 8.7 7.6 5.9 7.1 0.6 3.1 2 1 1 3 3 3 0 CagY type 1 repeat Dpy-30 PF05186.13 KOH01275.1 - 1.9e-15 56.3 0.1 2.6e-15 55.8 0.1 1.2 1 0 0 1 1 1 1 Dpy-30 motif Macoilin PF09726.9 KOH01275.1 - 6.6 5.2 8.8 6.2 5.2 8.8 1.0 1 0 0 1 1 1 0 Macoilin family Mito_carr PF00153.27 KOH01276.1 - 2.9e-11 43.1 0.0 0.00057 19.7 0.0 3.7 3 1 0 3 3 3 2 Mitochondrial carrier protein NBP1 PF08537.10 KOH01276.1 - 0.17 11.3 0.3 0.31 10.4 0.3 1.3 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 5HT_transport_N PF03491.13 KOH01276.1 - 0.43 10.8 2.5 11 6.3 0.2 3.1 3 0 0 3 3 3 0 Serotonin (5-HT) neurotransmitter transporter, N-terminus Ribosomal_L27e PF01777.18 KOH01277.1 - 3.5e-36 123.4 7.8 5.2e-36 122.9 7.8 1.2 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 KOH01277.1 - 0.00064 19.6 1.6 0.0012 18.7 1.6 1.5 1 0 0 1 1 1 1 KOW motif TRAPP PF04051.16 KOH01278.1 - 4.7e-47 159.4 0.0 7.4e-47 158.7 0.0 1.3 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component SSP160 PF06933.11 KOH01278.1 - 0.047 11.9 5.1 0.055 11.7 5.1 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PRP3 PF08572.10 KOH01279.1 - 1.1e-48 165.9 15.0 1.1e-48 165.9 15.0 1.7 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 KOH01279.1 - 8.7e-31 107.0 0.6 8.7e-31 107.0 0.6 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF1115) Neur_chan_memb PF02932.16 KOH01279.1 - 3 7.8 10.2 0.53 10.3 0.3 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Pkinase PF00069.25 KOH01282.1 - 3.5e-76 256.0 0.0 7.5e-76 255.0 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain AdenylateSensor PF16579.5 KOH01282.1 - 1.3e-57 193.4 0.2 3.1e-57 192.1 0.2 1.7 1 0 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Pkinase_Tyr PF07714.17 KOH01282.1 - 2.8e-37 128.4 0.0 4.5e-37 127.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.11 KOH01282.1 - 7.5e-21 74.0 3.1 1.1e-20 73.5 1.1 2.2 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 KOH01282.1 - 6.4e-10 38.8 0.0 1e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KOH01282.1 - 0.00022 20.9 0.8 0.00022 20.9 0.8 1.7 2 0 0 2 2 2 1 RIO1 family Haspin_kinase PF12330.8 KOH01282.1 - 0.00025 20.1 0.4 0.00054 19.0 0.4 1.5 1 0 0 1 1 1 1 Haspin like kinase domain YukC PF10140.9 KOH01282.1 - 0.00034 19.6 0.5 0.00054 18.9 0.5 1.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC Kdo PF06293.14 KOH01282.1 - 0.0064 15.9 0.2 0.012 15.0 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOH01282.1 - 0.039 13.9 0.2 0.5 10.2 0.3 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Rpr2 PF04032.16 KOH01283.1 - 1.3e-10 41.4 2.0 1.3e-10 41.4 2.0 2.2 2 1 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Pex24p PF06398.11 KOH01284.1 - 2e-86 290.3 8.5 2.4e-86 290.0 8.5 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Alk_phosphatase PF00245.20 KOH01286.1 - 2e-146 488.2 0.1 2.6e-146 487.8 0.1 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 KOH01286.1 - 7.7e-06 25.5 0.8 3.4e-05 23.3 0.0 2.3 3 0 0 3 3 3 1 Metalloenzyme superfamily MFS_1 PF07690.16 KOH01286.1 - 0.061 12.2 0.0 0.088 11.7 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily VWA_2 PF13519.6 KOH01286.1 - 0.082 13.6 0.1 12 6.6 0.0 3.0 2 1 0 2 2 2 0 von Willebrand factor type A domain cwf21 PF08312.12 KOH01287.1 - 1.5e-14 53.9 5.9 3.4e-14 52.7 5.9 1.7 1 0 0 1 1 1 1 cwf21 domain Trans_reg_C PF00486.28 KOH01287.1 - 0.027 14.6 0.3 0.54 10.4 0.1 2.2 1 1 1 2 2 2 0 Transcriptional regulatory protein, C terminal DUF1690 PF07956.11 KOH01287.1 - 0.072 13.5 12.7 0.095 13.1 12.7 1.2 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) Glyco_transf_15 PF01793.16 KOH01288.1 - 2.4e-135 451.0 12.3 3.1e-135 450.6 12.3 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Vps52 PF04129.12 KOH01289.1 - 6.3e-195 648.7 28.3 7.7e-195 648.5 28.3 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family Tli4_N PF18443.1 KOH01289.1 - 0.11 12.9 1.0 0.35 11.2 0.1 2.3 2 0 0 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain Leu_Phe_trans PF03588.14 KOH01289.1 - 0.13 11.7 0.0 0.35 10.4 0.0 1.7 1 0 0 1 1 1 0 Leucyl/phenylalanyl-tRNA protein transferase YL1 PF05764.13 KOH01290.1 - 5.2e-48 164.3 54.6 5.2e-48 164.3 54.6 3.0 2 2 1 3 3 3 1 YL1 nuclear protein YL1_C PF08265.11 KOH01290.1 - 6.2e-14 51.4 0.4 1.1e-13 50.7 0.4 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Snf7 PF03357.21 KOH01291.1 - 2.2e-41 141.3 28.1 2.8e-41 141.0 28.1 1.1 1 0 0 1 1 1 1 Snf7 Fmp27_WPPW PF10359.9 KOH01291.1 - 0.00032 19.7 15.2 0.00032 19.7 15.2 1.4 1 1 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain SKA1 PF07160.12 KOH01291.1 - 0.00083 19.3 16.2 0.00083 19.3 16.2 2.0 1 1 1 2 2 2 1 Spindle and kinetochore-associated protein 1 AceK PF06315.11 KOH01291.1 - 0.025 13.1 2.4 0.027 13.0 2.4 1.0 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) YlqD PF11068.8 KOH01291.1 - 0.045 14.1 24.5 0.47 10.8 24.2 2.3 1 1 0 1 1 1 0 YlqD protein TrfA PF07042.11 KOH01291.1 - 0.054 12.5 1.5 0.082 11.9 1.5 1.3 1 0 0 1 1 1 0 TrfA protein DUF2461 PF09365.10 KOH01291.1 - 0.072 13.0 1.0 0.47 10.4 0.1 2.0 1 1 1 2 2 2 0 Conserved hypothetical protein (DUF2461) TMF_TATA_bd PF12325.8 KOH01291.1 - 0.076 13.2 17.5 0.026 14.7 9.5 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF5446 PF17522.2 KOH01291.1 - 0.12 12.6 4.1 0.53 10.5 0.1 2.8 2 1 0 2 2 2 0 Family of unknown function (DUF5446) DUF1729 PF08354.10 KOH01291.1 - 0.31 9.9 6.3 0.38 9.6 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) V_ATPase_I PF01496.19 KOH01291.1 - 0.45 8.4 12.7 0.52 8.2 12.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Not3 PF04065.15 KOH01291.1 - 0.49 9.8 19.4 0.59 9.5 17.1 1.9 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Peptidase_S46 PF10459.9 KOH01291.1 - 0.74 8.4 12.4 0.88 8.1 12.4 1.1 1 0 0 1 1 1 0 Peptidase S46 Jnk-SapK_ap_N PF09744.9 KOH01291.1 - 0.84 9.9 21.0 0.097 12.9 12.5 2.4 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Syntaxin-6_N PF09177.11 KOH01291.1 - 0.86 10.2 11.5 0.31 11.6 3.7 2.6 2 1 0 2 2 2 0 Syntaxin 6, N-terminal BLOC1_2 PF10046.9 KOH01291.1 - 1.1 9.6 23.1 0.71 10.2 4.5 3.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cep57_MT_bd PF06657.13 KOH01291.1 - 1.2 9.6 11.3 0.45 11.0 3.8 2.8 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 RasGAP_C PF03836.15 KOH01291.1 - 1.9 8.6 19.9 0.78 9.9 14.1 2.3 1 1 1 2 2 2 0 RasGAP C-terminus DUF1664 PF07889.12 KOH01291.1 - 2.7 8.0 16.7 0.43 10.6 7.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Sec34 PF04136.15 KOH01291.1 - 3.9 7.4 18.6 0.42 10.5 9.9 2.6 1 1 2 3 3 3 0 Sec34-like family DHBP_synthase PF00926.19 KOH01292.1 - 4.2e-83 277.6 0.0 4.7e-83 277.4 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase WD40 PF00400.32 KOH01293.1 - 0.0019 19.0 1.7 0.017 16.0 0.6 3.1 2 1 0 2 2 2 1 WD domain, G-beta repeat Afaf PF15339.6 KOH01293.1 - 0.26 11.0 0.3 1.2 8.8 0.0 2.0 2 0 0 2 2 2 0 Acrosome formation-associated factor SLD5_C PF16922.5 KOH01294.1 - 4.4e-23 81.2 0.1 9.8e-23 80.1 0.1 1.6 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 KOH01294.1 - 4e-09 36.9 1.0 3.4e-08 33.9 0.7 2.2 2 0 0 2 2 2 1 GINS complex protein Pkinase PF00069.25 KOH01295.1 - 1.8e-63 214.4 0.0 3e-63 213.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH01295.1 - 4e-31 108.2 0.0 6.3e-31 107.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOH01295.1 - 1.1e-08 34.7 0.0 4.4e-05 22.9 0.0 3.1 3 0 0 3 3 3 2 Kinase-like FTA2 PF13095.6 KOH01295.1 - 1.4e-05 24.9 0.3 0.025 14.2 0.0 2.5 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 KOH01295.1 - 1.7e-05 23.8 0.3 0.00025 19.9 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 KOH01295.1 - 0.0011 18.4 0.0 0.0033 16.8 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOH01295.1 - 0.036 14.0 0.0 0.069 13.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOH01295.1 - 0.051 12.5 0.0 0.051 12.5 0.0 1.8 2 0 0 2 2 2 0 Haspin like kinase domain AAA_14 PF13173.6 KOH01295.1 - 0.073 13.1 0.1 0.17 11.9 0.1 1.7 1 0 0 1 1 1 0 AAA domain RIO1 PF01163.22 KOH01295.1 - 0.11 12.1 0.4 0.31 10.6 0.0 1.8 2 0 0 2 2 2 0 RIO1 family HlyIII PF03006.20 KOH01296.1 - 1.5e-57 194.9 24.6 1.8e-57 194.6 24.6 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF4118 PF13493.6 KOH01296.1 - 0.0047 16.7 0.1 0.0047 16.7 0.1 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4118) TMEM173 PF15009.6 KOH01296.1 - 0.51 9.4 2.8 0.85 8.7 2.8 1.3 1 0 0 1 1 1 0 Transmembrane protein 173 DDE_Tnp_1 PF01609.21 KOH01299.1 - 0.11 12.1 0.2 0.4 10.3 0.0 1.9 2 0 0 2 2 2 0 Transposase DDE domain Vps39_2 PF10367.9 KOH01299.1 - 1.8 9.0 4.6 0.88 10.1 0.2 2.7 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 CPL PF08144.11 KOH01300.1 - 2.4e-51 173.8 5.1 6.7e-49 165.9 0.0 4.6 5 1 1 6 6 6 1 CPL (NUC119) domain PUF PF00806.19 KOH01300.1 - 2e-05 24.0 7.9 0.13 12.0 0.0 6.6 7 0 0 7 7 7 1 Pumilio-family RNA binding repeat SAC3 PF12209.8 KOH01300.1 - 0.017 15.3 1.5 0.74 10.0 0.0 4.0 3 1 1 4 4 4 0 Leucine permease transcriptional regulator helical domain CDC45 PF02724.14 KOH01300.1 - 1.2 7.3 15.3 2.3 6.4 15.3 1.4 1 0 0 1 1 1 0 CDC45-like protein Sugar_tr PF00083.24 KOH01301.1 - 1.2e-134 449.6 28.3 1.4e-134 449.4 28.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOH01301.1 - 1.7e-31 109.5 31.8 1e-30 106.9 26.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 KOH01301.1 - 0.00019 20.0 0.4 0.00019 20.0 0.4 2.0 2 0 0 2 2 2 1 Transmembrane secretion effector Herpes_teg_N PF04843.12 KOH01301.1 - 0.075 12.7 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 Herpesvirus tegument protein, N-terminal conserved region Sec20 PF03908.13 KOH01302.1 - 1.9e-33 114.2 0.7 4.7e-33 113.0 0.7 1.7 1 0 0 1 1 1 1 Sec20 LCD1 PF09798.9 KOH01303.1 - 3.2e-206 686.6 36.0 3.7e-206 686.4 36.0 1.0 1 0 0 1 1 1 1 DNA damage checkpoint protein Importin_rep_6 PF18829.1 KOH01303.1 - 0.0084 16.2 1.3 0.12 12.5 0.4 3.0 2 0 0 2 2 2 1 Importin repeat 6 Phage_lysis PF03245.13 KOH01303.1 - 0.048 13.8 2.1 0.12 12.5 2.1 1.7 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein HDV_ag PF01517.18 KOH01303.1 - 0.074 12.8 0.4 0.13 12.0 0.4 1.3 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen eIF-4B PF06273.11 KOH01303.1 - 2.7 6.9 5.4 4.1 6.4 5.4 1.2 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B FapA PF03961.13 KOH01303.1 - 8.4 4.9 14.0 0.32 9.6 7.5 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A FHA PF00498.26 KOH01305.1 - 8.5e-06 26.0 0.0 2.9e-05 24.3 0.0 2.0 1 0 0 1 1 1 1 FHA domain S-AdoMet_synt_C PF02773.16 KOH01306.1 - 1.4e-64 216.2 0.1 2.3e-64 215.5 0.1 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 KOH01306.1 - 9.6e-46 154.5 1.6 1.4e-45 154.0 0.2 1.9 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 KOH01306.1 - 1.1e-44 151.5 0.0 2.4e-44 150.5 0.0 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain AdoMet_Synthase PF01941.19 KOH01306.1 - 0.023 13.5 0.0 0.11 11.3 0.0 1.9 2 0 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) PAP2 PF01569.21 KOH01307.1 - 1.6e-25 89.5 2.8 3.4e-24 85.2 3.4 2.1 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 KOH01307.1 - 0.00035 20.3 4.7 0.00035 20.3 4.7 2.0 2 1 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 KOH01307.1 - 0.012 16.2 6.1 0.012 16.2 6.1 2.5 3 0 0 3 3 3 0 PAP2 superfamily C-terminal PSP1 PF04468.12 KOH01308.1 - 6.7e-43 144.9 0.5 2e-42 143.4 0.5 1.9 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Cu-oxidase_2 PF07731.14 KOH01309.1 - 2.9e-27 95.0 3.8 9.4e-26 90.2 1.7 2.8 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 KOH01309.1 - 1.7e-19 70.0 7.6 3.5e-16 59.3 0.5 3.5 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.22 KOH01309.1 - 1.2e-17 64.5 3.1 2.4e-16 60.3 0.0 3.6 4 1 0 4 4 4 1 Multicopper oxidase Cupredoxin_1 PF13473.6 KOH01309.1 - 0.18 11.9 0.0 30 4.8 0.0 3.2 3 0 0 3 3 3 0 Cupredoxin-like domain Pkinase PF00069.25 KOH01310.1 - 2.6e-72 243.4 0.0 2e-71 240.5 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH01310.1 - 2.5e-34 118.7 0.2 1.4e-33 116.3 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Fungal_KA1 PF16797.5 KOH01310.1 - 1.5e-33 115.0 4.0 1.5e-33 115.0 4.0 2.3 3 0 0 3 3 3 1 Fungal kinase associated-1 domain Kinase-like PF14531.6 KOH01310.1 - 4.2e-07 29.6 0.0 3.3e-06 26.6 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KOH01310.1 - 0.24 11.3 0.0 0.47 10.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family AA_permease PF00324.21 KOH01311.1 - 5.5e-133 444.0 34.8 6.3e-133 443.8 34.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOH01311.1 - 8.3e-33 113.8 32.9 1e-32 113.6 32.9 1.1 1 0 0 1 1 1 1 Amino acid permease TPPK_C PF12555.8 KOH01311.1 - 1.3 9.1 5.3 4.8 7.3 0.1 2.8 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal Rad60-SLD PF11976.8 KOH01312.1 - 4e-19 68.2 0.5 6.4e-19 67.6 0.3 1.4 1 1 1 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KOH01312.1 - 7.5e-14 51.2 0.0 9.1e-14 51.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family SRP9-21 PF05486.12 KOH01312.1 - 0.12 12.8 0.1 0.14 12.6 0.1 1.1 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) Complex1_LYR_2 PF13233.6 KOH01313.1 - 2.4e-17 63.4 0.3 3.7e-17 62.9 0.3 1.4 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 KOH01313.1 - 3.8e-10 39.6 0.0 9.9e-10 38.3 0.0 1.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) DUF4028 PF13220.6 KOH01313.1 - 0.0076 16.0 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4028) ArnB_C PF18677.1 KOH01313.1 - 0.024 14.7 0.1 0.038 14.1 0.1 1.3 1 0 0 1 1 1 0 Archaellum regulatory network B, C-terminal domain pP_pnuc_1 PF18165.1 KOH01313.1 - 0.095 12.6 0.6 3.2 7.6 0.0 2.1 1 1 1 2 2 2 0 Predicted pPIWI-associating nuclease Fe_dep_repr_C PF02742.15 KOH01313.1 - 0.11 12.5 0.2 1.2 9.3 0.0 2.1 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain DUF3128 PF11326.8 KOH01314.1 - 1.9e-23 82.6 2.0 2.2e-23 82.4 2.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) CHCH PF06747.13 KOH01314.1 - 0.0093 16.1 2.0 2.7 8.2 0.1 2.4 2 0 0 2 2 2 2 CHCH domain Glutaredoxin PF00462.24 KOH01315.1 - 2.4e-16 59.7 0.0 5.4e-16 58.6 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 KOH01315.1 - 0.00052 20.0 0.2 0.0024 17.9 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_4 PF13462.6 KOH01315.1 - 0.073 13.2 0.2 0.16 12.1 0.2 1.5 1 1 0 1 1 1 0 Thioredoxin ZoocinA_TRD PF16775.5 KOH01316.1 - 0.079 13.1 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 Target recognition domain of lytic exoenzyme La PF05383.17 KOH01317.1 - 2.9e-18 65.7 0.0 7e-18 64.4 0.0 1.7 1 0 0 1 1 1 1 La domain Na_trans_assoc PF06512.13 KOH01317.1 - 3.5 7.9 14.2 0.38 11.0 6.1 2.8 2 1 0 2 2 2 0 Sodium ion transport-associated Hexokinase_2 PF03727.16 KOH01318.1 - 3.5e-73 246.0 0.0 5e-73 245.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KOH01318.1 - 9.1e-70 234.6 0.0 1.4e-69 234.0 0.0 1.3 1 0 0 1 1 1 1 Hexokinase GRASP55_65 PF04495.14 KOH01319.1 - 6.2e-39 133.5 0.0 1.4e-37 129.0 0.0 2.2 1 1 1 2 2 2 1 GRASP55/65 PDZ-like domain Spt20 PF12090.8 KOH01319.1 - 0.49 10.0 10.3 0.79 9.3 10.3 1.3 1 0 0 1 1 1 0 Spt20 family FKBP_C PF00254.28 KOH01320.1 - 4.6e-34 116.6 0.0 5.6e-34 116.3 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Recep_L_domain PF01030.24 KOH01321.1 - 1.8e-12 47.3 13.7 9.4e-06 25.7 0.1 4.2 1 1 2 3 3 3 2 Receptor L domain LRR_4 PF12799.7 KOH01321.1 - 0.0017 18.7 9.6 0.61 10.6 1.1 4.5 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KOH01321.1 - 0.11 12.5 8.7 1.1 9.2 0.4 3.1 1 1 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) Pkinase PF00069.25 KOH01322.1 - 7.5e-66 222.2 0.0 1.6e-65 221.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH01322.1 - 6.3e-48 163.3 0.0 9.7e-48 162.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOH01322.1 - 2.8e-06 26.9 0.0 0.0038 16.6 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 KOH01322.1 - 0.0045 15.8 0.0 0.009 14.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOH01322.1 - 0.058 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KOH01322.1 - 0.074 12.0 2.4 2.3 7.1 0.3 3.2 3 1 0 3 3 3 0 Haspin like kinase domain ArfGap PF01412.18 KOH01323.1 - 2.5e-30 104.9 2.7 6e-30 103.7 2.7 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pmp3 PF01679.17 KOH01325.1 - 9.9e-20 70.5 6.9 1.2e-19 70.3 6.9 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator PsbW PF07123.12 KOH01325.1 - 0.082 12.9 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Photosystem II reaction centre W protein (PsbW) RPAP1_C PF08620.10 KOH01326.1 - 1.9e-29 101.6 0.1 3.8e-29 100.6 0.1 1.5 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 KOH01326.1 - 6.9e-17 60.9 4.1 2.1e-16 59.4 4.1 1.9 1 0 0 1 1 1 1 RPAP1-like, N-terminal NAM-associated PF14303.6 KOH01326.1 - 0.22 12.2 13.7 0.057 14.1 6.0 2.3 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain UCR_14kD PF02271.16 KOH01328.1 - 2.8e-39 133.1 0.1 3.3e-39 132.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit ATP_transf PF09830.9 KOH01329.1 - 1.4e-20 73.2 0.0 2.2e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4931 PF16285.5 KOH01329.1 - 0.00026 20.4 0.0 0.00051 19.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4931) HIT PF01230.23 KOH01329.1 - 0.00068 20.3 0.0 0.0016 19.1 0.0 1.6 1 0 0 1 1 1 1 HIT domain Fumble PF03630.14 KOH01330.1 - 5.3e-124 413.7 8.1 1.2e-122 409.3 8.1 2.0 1 1 0 1 1 1 1 Fumble Kre28 PF17097.5 KOH01331.1 - 1.5e-121 405.8 29.8 1.7e-121 405.7 29.8 1.0 1 0 0 1 1 1 1 Spindle pole body component DUF4407 PF14362.6 KOH01331.1 - 0.062 12.6 4.9 0.099 12.0 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1216 PF06746.11 KOH01331.1 - 0.35 10.9 7.2 3.9 7.5 1.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1216) DUF2524 PF10732.9 KOH01331.1 - 3.6 8.0 9.4 0.15 12.4 1.4 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2524) DUF948 PF06103.11 KOH01331.1 - 5.4 7.4 6.6 3 8.2 0.2 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Aminotran_3 PF00202.21 KOH01332.1 - 9.9e-87 291.2 0.0 1.2e-86 291.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Fungal_trans PF04082.18 KOH01333.1 - 2.3e-31 108.8 2.1 3.9e-31 108.1 2.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain PA14 PF07691.12 KOH01334.1 - 2.7e-31 108.4 0.0 5.9e-31 107.3 0.0 1.6 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 KOH01334.1 - 7e-22 77.7 2.3 1.6e-21 76.6 0.2 2.6 2 0 0 2 2 2 1 GLEYA domain Flocculin PF00624.18 KOH01334.1 - 3.4e-07 30.4 17.2 3.4e-07 30.4 17.2 6.2 4 2 1 5 5 5 1 Flocculin repeat ELFV_dehydrog PF00208.21 KOH01335.1 - 3.7e-83 279.0 4.8 4.5e-83 278.7 4.8 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 KOH01335.1 - 1.6e-48 163.8 0.0 2.9e-48 163.0 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Coat_F PF07875.12 KOH01335.1 - 0.097 12.9 0.2 0.27 11.5 0.2 1.8 2 0 0 2 2 2 0 Coat F domain NAD_binding_7 PF13241.6 KOH01335.1 - 0.18 12.3 0.5 1.3 9.5 0.1 2.2 2 0 0 2 2 2 0 Putative NAD(P)-binding ADH_N PF08240.12 KOH01336.1 - 7.9e-35 119.0 0.6 1.4e-34 118.3 0.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOH01336.1 - 9.9e-22 77.3 0.0 1.5e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KOH01336.1 - 4e-06 26.5 0.0 5.8e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Pyr_redox_3 PF13738.6 KOH01336.1 - 0.0072 15.6 0.1 0.013 14.8 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N_2 PF13602.6 KOH01336.1 - 0.0088 17.1 0.0 0.016 16.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase F420_oxidored PF03807.17 KOH01336.1 - 0.085 13.5 0.1 0.19 12.3 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 KOH01336.1 - 0.12 11.7 0.1 0.27 10.6 0.0 1.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 KOH01336.1 - 0.15 12.1 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 KOH01336.1 - 0.26 10.8 1.3 0.75 9.3 1.3 1.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase ADH_N PF08240.12 KOH01337.1 - 7.6e-34 115.9 5.7 1.4e-33 115.0 5.7 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOH01337.1 - 3.5e-23 82.0 0.0 5.1e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KOH01337.1 - 1.1e-12 47.9 0.0 1.5e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 KOH01337.1 - 0.0087 15.4 0.0 0.027 13.7 0.0 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Alb1 PF09135.11 KOH01338.1 - 1e-26 93.8 10.1 1e-26 93.8 10.1 2.5 2 1 0 2 2 2 1 Alb1 CTV_P33 PF07184.11 KOH01338.1 - 0.16 11.0 0.7 0.44 9.6 0.2 1.8 2 0 0 2 2 2 0 Citrus tristeza virus P33 protein Calreticulin PF00262.18 KOH01339.1 - 5.4e-120 400.6 6.3 6.2e-120 400.4 6.3 1.0 1 0 0 1 1 1 1 Calreticulin family Kelch_4 PF13418.6 KOH01340.1 - 8.4e-11 41.7 0.9 0.0035 17.3 0.0 5.0 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KOH01340.1 - 7.5e-10 38.6 1.2 0.0058 16.6 0.0 5.7 5 1 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 KOH01340.1 - 6.3e-07 28.9 2.6 0.0035 16.9 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 KOH01340.1 - 0.00021 21.1 3.9 0.8 9.8 0.0 5.2 6 0 0 6 6 6 1 Kelch motif Kelch_3 PF13415.6 KOH01340.1 - 0.00077 19.7 1.6 3.4 8.1 0.0 5.0 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.6 KOH01340.1 - 0.0075 16.5 0.3 16 5.9 0.0 4.3 4 0 0 4 4 4 1 Kelch motif Peroxin-22 PF12827.7 KOH01341.1 - 4.6e-28 97.4 0.1 5.9e-28 97.0 0.1 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis protein family FPN1 PF06963.12 KOH01341.1 - 0.11 11.0 0.0 0.14 10.7 0.0 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) AMP-binding PF00501.28 KOH01342.1 - 5.5e-87 292.1 0.0 7e-87 291.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOH01342.1 - 1.9e-24 86.4 0.1 2.2e-23 83.0 0.1 2.5 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 KOH01342.1 - 1.1e-17 63.6 0.3 2.9e-17 62.3 0.3 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus TRP PF06011.12 KOH01343.1 - 2.6e-154 514.1 34.5 3.3e-154 513.7 34.5 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 KOH01343.1 - 2.2e-41 141.5 0.8 3.9e-41 140.7 0.8 1.4 1 0 0 1 1 1 1 ML-like domain Zn_clus PF00172.18 KOH01344.1 - 8.7e-12 45.0 10.5 1.5e-11 44.2 10.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF802 PF05650.11 KOH01344.1 - 0.21 12.1 0.3 0.41 11.2 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF802) DLH PF01738.18 KOH01345.1 - 1.9e-46 158.3 0.1 2.2e-46 158.2 0.1 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Ntox22 PF15527.6 KOH01345.1 - 0.079 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial toxin 22 EF_assoc_2 PF08356.12 KOH01346.1 - 3.2e-27 94.3 0.2 3.5e-26 91.0 0.0 2.4 2 0 0 2 2 2 1 EF hand associated Ras PF00071.22 KOH01346.1 - 9.3e-26 90.4 0.0 4e-14 52.5 0.0 2.7 2 1 0 2 2 2 2 Ras family EF_assoc_1 PF08355.12 KOH01346.1 - 2.3e-24 84.8 2.0 4.3e-24 83.9 2.0 1.5 1 0 0 1 1 1 1 EF hand associated Roc PF08477.13 KOH01346.1 - 9e-14 51.7 0.0 3.3e-05 24.1 0.0 3.4 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KOH01346.1 - 2.3e-07 30.9 0.0 0.038 14.1 0.0 3.1 2 1 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_1 PF00036.32 KOH01346.1 - 1.1e-06 27.8 1.2 0.00089 18.6 0.3 3.2 2 0 0 2 2 2 2 EF hand Dynamin_N PF00350.23 KOH01346.1 - 3.8e-05 23.8 0.1 0.14 12.2 0.0 2.5 2 0 0 2 2 2 2 Dynamin family Arf PF00025.21 KOH01346.1 - 0.00016 21.2 0.0 0.0028 17.1 0.0 2.5 3 0 0 3 3 3 1 ADP-ribosylation factor family EF-hand_6 PF13405.6 KOH01346.1 - 0.00025 20.7 2.1 0.027 14.4 0.2 3.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOH01346.1 - 0.00044 20.7 1.2 1.8 9.1 0.0 3.2 2 1 1 3 3 3 3 EF-hand domain pair AAA_16 PF13191.6 KOH01346.1 - 0.001 19.5 0.0 0.99 9.8 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 KOH01346.1 - 0.0021 18.0 3.7 0.15 11.9 0.0 4.3 4 1 0 5 5 4 1 RsgA GTPase ABC_tran PF00005.27 KOH01346.1 - 0.0025 18.3 0.0 2 8.9 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_28 PF13521.6 KOH01346.1 - 0.003 17.8 0.0 3.2 8.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain EF-hand_5 PF13202.6 KOH01346.1 - 0.0062 16.0 0.4 0.037 13.5 0.4 2.5 1 0 0 1 1 1 1 EF hand AAA_29 PF13555.6 KOH01346.1 - 0.0087 15.8 0.0 2.7 7.8 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 KOH01346.1 - 0.0094 16.5 0.0 1.9 9.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOH01346.1 - 0.014 15.7 0.0 3.3 8.0 0.0 3.1 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.6 KOH01346.1 - 0.017 14.8 0.0 3.6 7.2 0.0 2.4 2 1 0 2 2 2 0 AAA ATPase domain FeoB_N PF02421.18 KOH01346.1 - 0.025 14.1 0.1 7.5 6.1 0.0 2.9 3 0 0 3 3 3 0 Ferrous iron transport protein B MCM PF00493.23 KOH01346.1 - 0.042 12.9 0.0 2.7 7.0 0.0 2.4 2 0 0 2 2 2 0 MCM P-loop domain AAA_24 PF13479.6 KOH01346.1 - 0.061 13.0 0.0 1.4 8.6 0.0 2.6 3 0 0 3 3 2 0 AAA domain DUF815 PF05673.13 KOH01346.1 - 0.076 12.2 0.0 5.6 6.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Septin PF00735.18 KOH01346.1 - 0.079 12.2 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_33 PF13671.6 KOH01346.1 - 0.084 13.0 0.0 16 5.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 KOH01346.1 - 0.13 12.0 0.0 5.8 6.6 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein RNA_helicase PF00910.22 KOH01346.1 - 0.15 12.4 0.0 7.6 7.0 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Mto2_bdg PF12808.7 KOH01347.1 - 6.1e-05 23.2 8.5 6.1e-05 23.2 8.5 3.7 3 0 0 3 3 3 1 Micro-tubular organiser Mto1 C-term Mto2-binding region HMMR_N PF15905.5 KOH01347.1 - 0.0042 16.6 4.9 0.0042 16.6 4.9 4.4 2 1 1 4 4 4 2 Hyaluronan mediated motility receptor N-terminal BMFP PF04380.13 KOH01347.1 - 8.2 7.0 11.5 0.53 10.8 1.8 3.6 2 1 1 3 3 3 0 Membrane fusogenic activity BolA PF01722.18 KOH01348.1 - 1.8e-12 47.3 0.0 5.2e-12 45.9 0.0 1.7 1 1 0 1 1 1 1 BolA-like protein BolA PF01722.18 KOH01349.1 - 5e-25 87.6 0.3 8.3e-25 86.9 0.1 1.4 2 0 0 2 2 2 1 BolA-like protein Duffy_binding PF05424.11 KOH01349.1 - 0.046 13.8 0.1 0.07 13.2 0.1 1.4 1 1 0 1 1 1 0 Duffy binding domain GCV_H PF01597.19 KOH01350.1 - 7.4e-47 158.2 0.8 9e-47 158.0 0.8 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 KOH01350.1 - 0.0017 18.1 0.3 0.0044 16.8 0.1 1.8 1 1 0 1 1 1 1 Biotin-requiring enzyme DUF3453 PF11935.8 KOH01351.1 - 4.4e-60 203.1 0.4 1.1e-59 201.9 0.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) COPIIcoated_ERV PF07970.12 KOH01352.1 - 1.6e-76 257.0 0.4 1.9e-76 256.8 0.4 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KOH01352.1 - 3.9e-29 100.8 0.0 8.4e-29 99.8 0.0 1.6 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) CDC24 PF06395.11 KOH01353.1 - 7.9e-36 122.2 1.8 5.9e-35 119.4 0.9 2.7 2 0 0 2 2 2 1 CDC24 Calponin RhoGEF PF00621.20 KOH01353.1 - 4.3e-30 105.3 4.3 4.3e-30 105.3 4.3 2.9 2 1 0 2 2 2 1 RhoGEF domain PH_10 PF15411.6 KOH01353.1 - 5.3e-27 94.5 4.9 3.9e-25 88.5 4.9 3.1 1 1 0 1 1 1 1 Pleckstrin homology domain PB1 PF00564.24 KOH01353.1 - 0.00034 20.5 0.0 0.0016 18.3 0.0 2.2 1 1 1 2 2 2 1 PB1 domain PH PF00169.29 KOH01353.1 - 0.11 13.1 4.8 0.21 12.1 0.3 3.1 2 1 0 2 2 2 0 PH domain Cyclin_N PF00134.23 KOH01354.1 - 3.6e-24 84.9 2.5 6.6e-24 84.1 2.5 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyto_heme_lyase PF01265.17 KOH01355.1 - 7.2e-94 314.6 10.8 1.4e-92 310.4 10.8 2.3 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase PK PF00224.21 KOH01356.1 - 3.7e-169 562.1 1.7 4.6e-169 561.8 1.7 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KOH01356.1 - 2.5e-32 111.5 0.0 7.7e-32 110.0 0.0 1.9 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 KOH01356.1 - 1.1e-05 24.7 0.3 2.7e-05 23.4 0.1 1.7 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Mtd_N PF18454.1 KOH01356.1 - 0.056 13.5 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Major tropism determinant N-terminal domain PRD_Mga PF08270.11 KOH01357.1 - 0.01 15.6 0.7 0.018 14.7 0.7 1.5 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) PRD domain MMR_HSR1_Xtn PF16897.5 KOH01358.1 - 4.7e-37 126.2 0.0 9.1e-37 125.3 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 KOH01358.1 - 1.1e-22 79.8 0.1 2e-22 79.0 0.1 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 KOH01358.1 - 2.5e-19 69.4 0.0 4.7e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOH01358.1 - 4.2e-10 39.4 0.0 1.4e-09 37.7 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 KOH01358.1 - 0.016 14.2 0.1 0.029 13.3 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 KOH01358.1 - 0.021 15.1 0.2 11 6.3 0.0 2.6 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.23 KOH01358.1 - 0.024 14.7 0.4 4.1 7.4 0.3 2.4 1 1 1 2 2 2 0 Dynamin family GTP_EFTU PF00009.27 KOH01359.1 - 6.8e-33 113.9 3.0 9.8e-33 113.3 0.0 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KOH01359.1 - 1e-21 77.0 0.0 5.2e-21 74.7 0.0 2.3 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 KOH01359.1 - 7.4e-15 55.1 1.0 2.3e-09 37.5 0.0 3.2 2 0 0 2 2 2 2 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 KOH01359.1 - 2.2e-06 27.5 0.1 7.6e-06 25.8 0.1 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 KOH01359.1 - 8.6e-06 25.8 0.0 8.6e-06 25.8 0.0 3.5 3 1 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 KOH01359.1 - 0.00055 20.2 0.0 0.00055 20.2 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 KOH01359.1 - 0.058 12.9 0.0 0.28 10.7 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B ThiS-like PF14453.6 KOH01359.1 - 0.22 11.6 1.6 7.1 6.8 0.6 3.1 2 0 0 2 2 2 0 ThiS-like ubiquitin Mis12 PF05859.12 KOH01360.1 - 1.1e-42 145.3 2.3 1.1e-42 145.3 2.3 2.0 2 0 0 2 2 2 1 Mis12 protein TetR_C_4 PF08359.11 KOH01360.1 - 0.029 14.5 0.7 0.07 13.3 0.4 1.9 1 1 0 1 1 1 0 YsiA-like protein, C-terminal region DrrA_P4M PF14860.6 KOH01360.1 - 0.037 13.9 1.7 0.094 12.6 1.7 1.7 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain DUF1189 PF06691.11 KOH01360.1 - 0.044 13.3 1.3 0.062 12.9 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Phasin PF05597.11 KOH01360.1 - 0.058 13.4 3.0 3.9 7.5 0.1 2.9 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) 3H PF02829.14 KOH01360.1 - 0.09 13.1 1.3 0.19 12.0 0.3 1.9 1 1 1 2 2 2 0 3H domain DUF2203 PF09969.9 KOH01360.1 - 1.9 9.2 5.1 2.5 8.8 0.3 2.7 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF16 PF01519.16 KOH01360.1 - 4.7 7.8 10.2 3.7 8.1 7.2 2.3 1 1 2 3 3 3 0 Protein of unknown function DUF16 SWIRM PF04433.17 KOH01361.1 - 3.6e-09 36.9 0.0 9.1e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain RNase_P_Rpp14 PF01900.19 KOH01362.1 - 3.5e-33 113.9 0.0 4.5e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family SKIP_SNW PF02731.15 KOH01363.1 - 5.5e-44 149.7 0.7 8.8e-44 149.0 0.7 1.3 1 0 0 1 1 1 1 SKIP/SNW domain SOG2 PF10428.9 KOH01364.1 - 5.4 6.1 31.8 8.1 5.5 31.8 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Myosin_head PF00063.21 KOH01365.1 - 1e-279 929.5 15.9 1.5e-279 929.0 15.9 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 KOH01365.1 - 1.4e-16 60.6 0.4 4.7e-16 59.0 0.4 2.0 1 0 0 1 1 1 1 DIL domain IQ PF00612.27 KOH01365.1 - 2.6e-05 23.6 27.6 0.0058 16.3 0.5 6.6 6 0 0 6 6 6 3 IQ calmodulin-binding motif Myosin_N PF02736.19 KOH01365.1 - 0.00028 20.7 0.1 0.00078 19.2 0.1 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain NB-ARC PF00931.22 KOH01365.1 - 0.0011 18.3 0.7 0.054 12.7 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 KOH01365.1 - 0.031 14.7 0.0 0.39 11.1 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 KOH01365.1 - 0.054 13.8 0.1 0.054 13.8 0.1 2.8 3 1 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 KOH01365.1 - 0.084 12.6 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 KOH01365.1 - 0.085 13.4 1.4 0.26 11.8 0.0 2.5 2 0 0 2 2 2 0 ABC transporter Hph PF13694.6 KOH01366.1 - 5.1e-55 186.7 7.6 5.1e-55 186.7 7.6 2.6 1 1 0 2 2 2 1 Sec63/Sec62 complex-interacting family Saw1 PF11561.8 KOH01367.1 - 7e-84 281.2 4.9 8e-84 281.0 4.9 1.0 1 0 0 1 1 1 1 Single strand annealing-weakened 1 PhoLip_ATPase_C PF16212.5 KOH01368.1 - 5.6e-83 278.5 27.3 5.6e-83 278.5 27.3 2.5 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KOH01368.1 - 2.4e-24 84.8 4.4 6e-24 83.5 4.4 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KOH01368.1 - 1.6e-10 41.7 0.2 5.6e-05 23.5 0.0 3.3 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOH01368.1 - 2e-09 37.4 0.0 8.9e-09 35.3 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KOH01368.1 - 5.3e-07 29.3 0.1 1.5e-06 27.9 0.1 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KOH01368.1 - 0.0014 18.4 0.5 0.011 15.4 0.4 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2204 PF09970.9 KOH01368.1 - 0.052 13.2 0.1 0.15 11.7 0.1 1.8 1 0 0 1 1 1 0 Nucleotidyl transferase of unknown function (DUF2204) DUF3069 PF11269.8 KOH01368.1 - 0.11 12.8 0.0 0.89 9.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3069) DNA_III_psi PF03603.13 KOH01368.1 - 0.15 12.3 0.1 0.32 11.2 0.1 1.5 1 0 0 1 1 1 0 DNA polymerase III psi subunit Ribosomal_L28e PF01778.17 KOH01369.1 - 4e-40 137.1 2.2 4e-40 137.1 2.2 1.8 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 KOH01369.1 - 1.2e-30 106.0 15.9 1.2e-30 106.0 15.9 2.6 1 1 1 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 KOH01369.1 - 0.00026 20.5 23.8 0.00032 20.2 23.8 1.2 1 0 0 1 1 1 1 BUD22 IMUP PF15761.5 KOH01369.1 - 0.0058 17.3 10.6 0.0058 17.3 10.6 2.0 2 0 0 2 2 2 1 Immortalisation up-regulated protein Ribosomal_L24e PF01246.20 KOH01369.1 - 0.023 14.9 2.7 0.11 12.7 0.1 2.5 2 0 0 2 2 2 0 Ribosomal protein L24e PYC_OADA PF02436.18 KOH01369.1 - 0.13 12.0 4.2 0.25 11.1 4.2 1.6 1 1 0 1 1 1 0 Conserved carboxylase domain TFIIF_alpha PF05793.12 KOH01369.1 - 1.7 7.2 33.2 2.2 6.8 33.2 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 KOH01369.1 - 2.2 6.4 23.2 3.6 5.7 23.2 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4598 PF15370.6 KOH01369.1 - 6.8 7.2 18.2 1.7 9.1 14.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4598) RasGEF PF00617.19 KOH01370.1 - 6.1e-42 143.8 0.6 3.2e-41 141.5 0.6 2.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 KOH01370.1 - 1.5e-15 57.3 6.2 1.3e-13 51.1 0.2 4.1 3 0 0 3 3 3 2 RasGEF N-terminal motif PMT PF02366.18 KOH01371.1 - 1.1e-96 323.2 20.5 1.1e-96 323.2 20.5 2.1 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 KOH01371.1 - 4.9e-61 205.8 12.6 4.9e-61 205.8 12.6 2.5 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 KOH01371.1 - 1.7e-23 83.4 0.2 2.4e-22 79.7 0.0 2.0 2 0 0 2 2 2 1 MIR domain Nucleoside_tran PF01733.18 KOH01372.1 - 6.4e-98 327.9 3.8 6.4e-98 327.9 3.8 1.6 2 0 0 2 2 2 1 Nucleoside transporter DUF5383 PF17355.2 KOH01372.1 - 0.2 12.0 0.2 0.2 12.0 0.2 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5383) PBP1_TM PF14812.6 KOH01372.1 - 0.26 11.7 7.3 1.9 8.9 0.9 2.9 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2371 PF10177.9 KOH01372.1 - 0.47 10.6 1.8 0.61 10.3 0.0 2.1 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2371) Sigma70_ner PF04546.13 KOH01372.1 - 1.3 8.8 5.9 0.16 11.8 1.2 1.7 2 0 0 2 2 2 0 Sigma-70, non-essential region Exo_endo_phos PF03372.23 KOH01373.1 - 9.2e-22 77.7 0.1 1.5e-21 77.0 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 KOH01373.1 - 8.3e-17 60.7 16.4 7.3e-08 32.1 0.9 3.5 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 KOH01373.1 - 3.7e-11 43.1 2.9 1.1e-07 32.0 0.6 4.8 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOH01373.1 - 2.4 9.0 20.2 0.51 11.1 0.1 6.4 5 1 0 5 5 5 0 Leucine Rich Repeat RCC1 PF00415.18 KOH01374.1 - 2.8e-25 88.7 18.3 5.5e-13 49.3 0.2 5.6 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOH01374.1 - 3.1e-15 55.5 29.3 1.2e-07 31.4 1.3 6.3 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat DUF1459 PF07312.11 KOH01374.1 - 0.074 13.3 0.2 0.7 10.1 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1459) SNF2_N PF00176.23 KOH01375.1 - 5.3e-61 206.3 0.2 1.1e-60 205.2 0.2 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOH01375.1 - 4.5e-21 75.3 0.1 8.2e-17 61.6 0.1 3.0 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 KOH01375.1 - 4.1e-12 46.4 0.0 1.9e-11 44.3 0.0 2.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOH01375.1 - 1.5e-06 28.1 0.1 8.9e-06 25.6 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase EI24 PF07264.11 KOH01376.1 - 4.1e-08 33.7 18.3 5.9e-08 33.2 18.3 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) TMEM70 PF06979.12 KOH01376.1 - 0.93 9.9 10.6 0.2 12.1 0.9 2.4 2 0 0 2 2 2 0 Assembly, mitochondrial proton-transport ATP synth complex Pkinase PF00069.25 KOH01377.1 - 4.5e-66 222.9 0.6 5e-65 219.5 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH01377.1 - 1.7e-22 79.9 0.0 2.8e-22 79.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOH01377.1 - 4.1e-09 36.2 0.0 7.2e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOH01377.1 - 0.0034 17.3 0.0 0.0083 16.1 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family PAS_9 PF13426.7 KOH01377.1 - 0.0064 16.7 0.0 0.067 13.4 0.0 2.6 2 0 0 2 2 2 1 PAS domain Pkinase_fungal PF17667.1 KOH01377.1 - 0.0076 15.1 0.0 0.019 13.7 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOH01377.1 - 0.0086 15.5 0.1 0.017 14.5 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 KOH01377.1 - 0.0087 15.1 0.2 0.023 13.8 0.2 1.6 1 0 0 1 1 1 1 Seadornavirus VP7 RIO1 PF01163.22 KOH01377.1 - 0.062 12.9 0.1 0.15 11.7 0.1 1.6 1 0 0 1 1 1 0 RIO1 family PAS PF00989.25 KOH01377.1 - 0.11 12.5 0.0 2.9 7.9 0.0 2.6 2 0 0 2 2 2 0 PAS fold HEAT PF02985.22 KOH01378.1 - 2.4e-41 136.2 21.0 0.013 15.7 0.1 13.4 13 0 0 13 13 13 10 HEAT repeat HEAT_2 PF13646.6 KOH01378.1 - 2.3e-29 101.6 0.8 3.6e-09 36.9 0.0 7.8 4 3 2 7 7 7 6 HEAT repeats Vac14_Fab1_bd PF12755.7 KOH01378.1 - 5.4e-13 49.4 6.4 0.071 13.7 0.0 7.8 3 3 5 8 8 8 4 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 KOH01378.1 - 3.6e-08 33.7 7.1 4.3 8.0 0.0 8.9 8 1 1 9 9 9 2 HEAT-like repeat Cnd1 PF12717.7 KOH01378.1 - 6.5e-07 29.5 15.0 0.012 15.7 2.1 5.5 4 1 2 6 6 6 3 non-SMC mitotic condensation complex subunit 1 Ecm29 PF13001.7 KOH01378.1 - 2.4e-05 23.2 6.2 0.013 14.2 0.0 5.1 3 1 1 5 5 5 2 Proteasome stabiliser Arm PF00514.23 KOH01378.1 - 0.00095 19.1 1.2 0.97 9.6 0.0 5.3 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat TAF6_C PF07571.13 KOH01378.1 - 0.0081 16.5 0.1 4.7 7.6 0.0 3.9 3 1 0 3 3 3 1 TAF6 C-terminal HEAT repeat domain DUF1981 PF09324.10 KOH01378.1 - 0.06 13.2 0.3 28 4.6 0.0 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1981) Band_7 PF01145.25 KOH01378.1 - 0.088 12.8 2.5 6 6.8 0.0 3.4 3 1 0 3 3 3 0 SPFH domain / Band 7 family TAF PF02969.17 KOH01378.1 - 0.12 12.6 0.0 0.78 10.0 0.0 2.5 1 1 1 2 2 2 0 TATA box binding protein associated factor (TAF) HhH-GPD PF00730.25 KOH01379.1 - 2.9e-23 82.4 0.0 4.9e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 KOH01379.1 - 2.5e-09 36.5 0.0 7.5e-09 35.0 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 KOH01379.1 - 0.02 15.5 0.0 0.053 14.1 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain SNARE PF05739.19 KOH01380.1 - 0.0059 16.6 0.5 0.01 15.8 0.5 1.5 1 0 0 1 1 1 1 SNARE domain PBP1_TM PF14812.6 KOH01380.1 - 2.8 8.4 7.3 1.3 9.5 4.7 1.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cys_Met_Meta_PP PF01053.20 KOH01381.1 - 1e-143 478.5 0.1 1.2e-143 478.3 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KOH01381.1 - 0.001 18.3 0.1 0.0022 17.2 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KOH01381.1 - 0.0055 15.7 0.1 0.012 14.6 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KOH01381.1 - 0.12 11.6 0.0 0.49 9.6 0.0 1.8 2 0 0 2 2 2 0 Beta-eliminating lyase DUF4314 PF14192.6 KOH01382.1 - 0.13 12.2 0.0 0.4 10.6 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4314) DUF572 PF04502.13 KOH01382.1 - 4.8 6.7 46.4 6.3 6.3 41.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) MDM10 PF12519.8 KOH01383.1 - 1.3e-150 502.4 11.5 1.5e-150 502.2 11.5 1.0 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 CK2S PF15011.6 KOH01383.1 - 0.062 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Casein Kinase 2 substrate Spo7 PF03907.13 KOH01384.1 - 1.3e-73 247.1 5.6 1.7e-73 246.8 5.6 1.1 1 0 0 1 1 1 1 Spo7-like protein FUN14 PF04930.15 KOH01385.1 - 3.5e-06 27.3 1.2 6.8e-06 26.4 1.2 1.5 1 0 0 1 1 1 1 FUN14 family EMP24_GP25L PF01105.24 KOH01386.1 - 1.3e-35 123.0 0.1 1.5e-35 122.8 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Innexin PF00876.18 KOH01386.1 - 0.039 13.3 0.2 0.044 13.1 0.2 1.1 1 0 0 1 1 1 0 Innexin DUF4307 PF14155.6 KOH01386.1 - 0.27 11.1 2.1 4.3 7.2 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4307) Holin_SPP1 PF04688.13 KOH01386.1 - 0.28 11.4 2.2 0.43 10.8 0.1 2.1 2 0 0 2 2 2 0 SPP1 phage holin HSP70 PF00012.20 KOH01387.1 - 2e-263 875.1 8.3 2.3e-263 874.9 8.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOH01387.1 - 6.9e-18 64.5 0.0 1.2e-16 60.4 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 KOH01387.1 - 0.0014 18.4 0.0 0.0049 16.6 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 KOH01387.1 - 0.0069 15.4 0.3 0.11 11.5 0.1 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain PilM_2 PF11104.8 KOH01387.1 - 0.021 13.9 0.0 1.6 7.7 0.0 2.3 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; FtsA PF14450.6 KOH01387.1 - 0.078 13.4 3.3 20 5.7 0.0 3.5 3 2 0 3 3 3 0 Cell division protein FtsA DUF1542 PF07564.11 KOH01387.1 - 1.2 9.3 7.9 0.1 12.7 2.7 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) MutS_III PF05192.18 KOH01387.1 - 5.3 7.2 7.7 7 6.8 1.4 2.5 2 1 0 2 2 2 0 MutS domain III EF1_GNE PF00736.19 KOH01388.1 - 4e-33 113.4 1.9 7.4e-33 112.6 1.9 1.4 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 KOH01388.1 - 4.8e-13 49.3 5.3 4.8e-13 49.3 5.3 3.2 4 0 0 4 4 4 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_2 PF13410.6 KOH01388.1 - 0.019 15.0 0.2 0.14 12.2 0.1 2.3 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOH01388.1 - 0.025 14.8 3.7 0.14 12.4 0.6 2.8 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain FAD_binding_5 PF00941.21 KOH01388.1 - 0.11 12.2 0.1 0.25 11.0 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain in molybdopterin dehydrogenase DNA_pol3_a_NII PF11490.8 KOH01388.1 - 0.25 11.2 2.9 0.34 10.8 0.0 2.1 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Vps8 PF12816.7 KOH01389.1 - 1.8e-57 194.1 1.7 1.8e-57 194.1 1.7 2.0 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 zf-C3HC4_2 PF13923.6 KOH01389.1 - 0.0009 19.0 2.3 0.0039 17.0 2.3 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Clathrin PF00637.20 KOH01389.1 - 0.00095 19.1 17.0 0.0075 16.1 0.1 5.0 4 2 0 4 4 4 2 Region in Clathrin and VPS zf-C3HC4 PF00097.25 KOH01389.1 - 0.0027 17.6 2.0 0.011 15.6 2.0 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOH01389.1 - 0.0032 17.8 1.3 0.012 15.9 1.3 2.1 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 KOH01389.1 - 0.0047 16.9 0.7 0.016 15.2 0.7 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 KOH01389.1 - 0.014 15.6 1.0 0.058 13.7 1.0 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KOH01389.1 - 0.026 14.5 5.3 0.075 13.0 5.3 1.9 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_11 PF17123.5 KOH01389.1 - 0.032 14.0 1.2 0.12 12.1 1.2 2.0 1 0 0 1 1 1 0 RING-like zinc finger zf-C3H2C3 PF17122.5 KOH01389.1 - 0.042 13.9 0.1 0.042 13.9 0.1 2.0 2 0 0 2 2 1 0 Zinc-finger PHD PF00628.29 KOH01389.1 - 0.088 12.7 2.0 0.29 11.1 2.0 1.9 1 0 0 1 1 1 0 PHD-finger zf-ANAPC11 PF12861.7 KOH01389.1 - 0.11 12.6 2.0 0.12 12.5 0.4 1.9 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 KOH01389.1 - 0.15 12.3 1.6 0.43 10.8 1.6 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING WD40 PF00400.32 KOH01389.1 - 0.24 12.3 0.9 1.7 9.6 0.1 2.8 2 0 0 2 2 2 0 WD domain, G-beta repeat B-block_TFIIIC PF04182.12 KOH01390.1 - 2.9e-15 56.2 0.1 1.1e-14 54.3 0.1 2.1 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC Band_7_C PF16200.5 KOH01390.1 - 0.07 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 C-terminal region of band_7 Fungal_lectin_2 PF18647.1 KOH01390.1 - 0.073 13.5 0.2 10 6.6 0.0 3.4 3 0 0 3 3 3 0 Alpha-galactosyl-binding fungal lectin EMP24_GP25L PF01105.24 KOH01392.1 - 3.4e-47 160.7 0.1 4.3e-47 160.4 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SdrD_B PF17210.3 KOH01392.1 - 0.0013 18.9 0.1 0.0024 18.1 0.1 1.4 1 0 0 1 1 1 1 SdrD B-like domain CCDC144C PF14915.6 KOH01392.1 - 0.086 11.9 0.4 0.12 11.4 0.4 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region Herpes_UL73 PF03554.13 KOH01392.1 - 0.42 10.7 0.1 0.42 10.7 0.1 2.0 2 0 0 2 2 2 0 UL73 viral envelope glycoprotein WD40 PF00400.32 KOH01393.1 - 4.9e-13 49.3 8.5 3.5e-07 30.8 0.2 5.9 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOH01393.1 - 1.1e-08 35.3 0.1 0.23 11.8 0.0 3.9 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOH01393.1 - 4.5e-06 25.9 0.0 0.013 14.5 0.4 3.4 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KOH01393.1 - 0.00025 21.0 0.2 0.028 14.3 0.0 3.0 1 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Phytase PF02333.15 KOH01393.1 - 0.0064 15.5 0.1 0.0084 15.1 0.1 1.2 1 0 0 1 1 1 1 Phytase PD40 PF07676.12 KOH01393.1 - 0.022 14.7 0.1 0.26 11.3 0.0 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Frtz PF11768.8 KOH01393.1 - 0.024 12.9 0.0 0.047 12.0 0.0 1.4 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz PilM PF07419.12 KOH01393.1 - 0.061 13.5 0.1 0.22 11.7 0.1 1.7 1 1 0 1 1 1 0 PilM Rep_fac-A_C PF08646.10 KOH01394.1 - 3e-61 205.5 1.7 1.1e-58 197.1 0.6 2.3 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 KOH01394.1 - 6.2e-33 112.6 1.1 8.4e-30 102.6 0.0 3.9 4 0 0 4 4 4 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 KOH01394.1 - 1.1e-13 50.9 0.9 1.9e-08 34.2 0.0 4.2 4 0 0 4 4 4 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 KOH01394.1 - 9.5e-06 25.5 0.0 0.01 15.6 0.0 3.5 4 0 0 4 4 4 1 Cell division control protein 24, OB domain 3 Rep-A_N PF04057.12 KOH01394.1 - 5.4e-05 23.2 0.1 0.00014 21.8 0.1 1.8 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain DUF223 PF02721.14 KOH01394.1 - 0.00062 20.0 1.0 0.0025 18.1 0.3 2.3 2 0 0 2 2 2 1 Domain of unknown function DUF223 BRCA-2_OB1 PF09103.10 KOH01394.1 - 0.0094 15.9 0.0 0.031 14.2 0.0 1.9 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 IL12 PF03039.14 KOH01394.1 - 0.028 13.8 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 Interleukin-12 alpha subunit tRNA_int_endo PF01974.17 KOH01395.1 - 5.6e-13 48.8 0.0 1e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain DUF5505 PF17610.2 KOH01395.1 - 0.15 12.1 1.2 0.25 11.3 0.8 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5505) DUP PF00674.18 KOH01397.1 - 2.9e-32 110.9 4.3 5.9e-32 109.9 4.3 1.5 1 1 0 1 1 1 1 DUP family DUF2189 PF09955.9 KOH01398.1 - 0.38 11.0 6.4 0.11 12.8 2.7 1.8 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2189) Phospholamban PF04272.14 KOH01398.1 - 2.2 7.8 7.5 0.31 10.5 1.6 2.7 1 1 1 2 2 2 0 Phospholamban SH3_1 PF00018.28 KOH01399.1 - 8.1e-11 41.4 0.0 2.2e-10 40.0 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOH01399.1 - 0.021 14.7 0.0 0.044 13.7 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain SAICAR_synt PF01259.18 KOH01400.1 - 1.2e-101 339.5 0.0 1.4e-101 339.3 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase UPF0086 PF01868.16 KOH01400.1 - 0.036 14.0 0.0 0.19 11.6 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function UPF0086 Pkinase PF00069.25 KOH01401.1 - 2e-53 181.4 1.1 4.4e-52 177.1 1.1 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH01401.1 - 5.3e-31 107.8 0.1 9.8e-30 103.7 0.1 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOH01401.1 - 0.022 13.6 0.0 0.035 12.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 KOH01401.1 - 0.032 13.5 0.0 0.06 12.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like PPP5 PF08321.12 KOH01401.1 - 0.047 14.0 0.4 0.16 12.3 0.1 2.0 2 0 0 2 2 2 0 PPP5 TPR repeat region Pkinase PF00069.25 KOH01402.1 - 1.2e-71 241.2 0.0 1.8e-71 240.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOH01402.1 - 1.6e-50 171.8 0.0 2.6e-50 171.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOH01402.1 - 0.0022 16.8 0.0 0.0037 16.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOH01402.1 - 0.0027 17.1 0.1 0.036 13.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like DUF4668 PF15701.5 KOH01403.1 - 3.6e-34 117.9 5.8 4.9e-34 117.5 5.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4668) Sprouty PF05210.13 KOH01403.1 - 0.0025 18.1 0.3 0.0041 17.5 0.3 1.3 1 0 0 1 1 1 1 Sprouty protein (Spry) DUP PF00674.18 KOH01404.1 - 2.4e-10 40.5 3.5 2.9e-10 40.2 3.5 1.1 1 0 0 1 1 1 1 DUP family DUP PF00674.18 KOH01405.1 - 1.7e-30 105.2 0.5 2.8e-30 104.5 0.5 1.4 1 0 0 1 1 1 1 DUP family Oxysterol_BP PF01237.18 KOH01406.1 - 1.1e-131 439.1 0.2 2.5e-131 437.9 0.2 1.6 1 0 0 1 1 1 1 Oxysterol-binding protein Ank_5 PF13857.6 KOH01406.1 - 1.2e-11 44.6 0.1 0.00035 20.8 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) PH PF00169.29 KOH01406.1 - 1.3e-10 41.7 0.2 4.8e-10 39.9 0.2 2.1 1 0 0 1 1 1 1 PH domain Ank_4 PF13637.6 KOH01406.1 - 2.3e-10 40.8 0.1 0.00032 21.2 0.0 3.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOH01406.1 - 7e-10 38.3 0.1 0.018 15.5 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 KOH01406.1 - 2.1e-09 37.8 0.0 0.00024 21.6 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) PH_8 PF15409.6 KOH01406.1 - 1.5e-07 31.6 1.2 2.6e-07 30.8 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain Ank PF00023.30 KOH01406.1 - 7.7e-07 29.3 0.1 0.011 16.1 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat PH_11 PF15413.6 KOH01406.1 - 0.14 12.6 6.2 0.081 13.4 1.2 3.3 3 1 0 3 3 3 0 Pleckstrin homology domain ALMT PF11744.8 KOH01406.1 - 0.16 10.7 10.5 0.32 9.8 10.5 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter PA14 PF07691.12 KOH01407.1 - 1.2e-31 109.5 0.0 1.7e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 KOH01407.1 - 3.8e-22 78.5 0.2 8.7e-22 77.4 0.2 1.7 1 0 0 1 1 1 1 GLEYA domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Saccharomyces_eubayanus-SEUB3.0/GCA_001298625.1_SEUB3.0_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Saccharomyces_eubayanus-SEUB3.0/GCA_001298625.1_SEUB3.0_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Saccharomyces_eubayanus-SEUB3.0/GCA_001298625.1_SEUB3.0_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Saccharomyces_eubayanus-SEUB3.0/GCA_001298625.1_SEUB3.0_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 04:42:33 2019 # [ok]