# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- FAD_binding_8 PF08022.7 KOG96028.1 - 2.9e-28 97.7 0.0 5.9e-28 96.8 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 KOG96028.1 - 1e-23 84.0 0.0 1.7e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 KOG96028.1 - 1e-17 64.3 15.1 3.4e-17 62.7 10.4 1.9 1 0 0 1 1 1 1 Ferric reductase like transmembrane component PGM_PMM_III PF02880.11 KOG96029.1 - 0.066 13.2 7.5 0.069 13.1 0.9 2.4 1 1 1 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Pyocin_S PF06958.7 KOG96029.1 - 7.2 6.9 11.7 3.9 7.8 4.6 2.1 1 1 1 2 2 2 0 S-type Pyocin SR-25 PF10500.4 KOG96030.1 - 0.44 9.9 9.8 0.56 9.6 6.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.10 KOG96030.1 - 0.91 10.0 7.9 1.6 9.3 5.5 1.5 1 1 0 1 1 1 0 Chorion family 2 FAD-oxidase_C PF02913.14 KOG96031.1 - 8.7e-49 166.0 0.0 1.2e-48 165.6 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 KOG96031.1 - 4.4e-36 123.3 0.0 8.3e-36 122.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain SNO PF01174.14 KOG96032.1 - 8e-87 289.7 0.1 9.2e-87 289.5 0.1 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 KOG96032.1 - 1.6e-08 34.3 0.0 2.7e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.19 KOG96032.1 - 0.078 12.4 0.0 0.17 11.3 0.0 1.5 2 0 0 2 2 2 0 DJ-1/PfpI family BPL_N PF09825.4 KOG96032.1 - 0.093 11.4 0.0 1.6 7.4 0.0 2.0 2 0 0 2 2 2 0 Biotin-protein ligase, N terminal SOR_SNZ PF01680.12 KOG96033.1 - 1.7e-107 357.6 5.3 2.2e-107 357.3 3.7 1.1 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.9 KOG96033.1 - 1.9e-08 33.7 1.5 2.4e-07 30.1 0.0 2.4 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 KOG96033.1 - 0.0076 15.5 0.0 0.06 12.5 0.0 2.2 2 0 0 2 2 2 1 Histidine biosynthesis protein Dus PF01207.12 KOG96033.1 - 0.011 14.6 0.2 2.2 7.0 0.0 2.4 2 1 0 2 2 2 0 Dihydrouridine synthase (Dus) NMO PF03060.10 KOG96033.1 - 0.011 14.9 0.2 0.044 12.9 0.0 2.0 2 0 0 2 2 2 0 Nitronate monooxygenase NanE PF04131.9 KOG96033.1 - 0.042 12.8 1.3 0.14 11.1 0.0 2.2 2 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase IGPS PF00218.16 KOG96033.1 - 0.052 12.5 0.0 0.14 11.1 0.0 1.8 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase 1-cysPrx_C PF10417.4 KOG96033.1 - 0.12 12.0 0.2 5.4 6.7 0.0 2.5 2 0 0 2 2 2 0 C-terminal domain of 1-Cys peroxiredoxin TMP-TENI PF02581.12 KOG96033.1 - 0.36 9.9 3.2 0.44 9.6 0.0 2.5 3 1 0 3 3 3 0 Thiamine monophosphate synthase/TENI NMT1 PF09084.6 KOG96034.1 - 7.1e-79 264.3 0.0 8.7e-79 264.0 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.1 KOG96034.1 - 7.1e-08 32.1 0.1 2.1e-06 27.3 0.0 2.7 1 1 0 1 1 1 1 NMT1-like family Phosphonate-bd PF12974.2 KOG96034.1 - 0.0043 16.4 0.0 0.0071 15.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein 2Fe-2S_thioredx PF01257.14 KOG96034.1 - 0.0073 15.9 1.3 0.013 15.0 0.9 1.4 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin PBP_like PF12727.2 KOG96034.1 - 0.12 11.3 0.0 0.43 9.4 0.0 1.8 1 1 0 1 1 1 0 PBP superfamily domain Flp_C PF05202.7 KOG96035.1 - 6.6e-96 320.2 3.2 7.8e-96 319.9 1.6 1.6 1 1 1 2 2 2 1 Recombinase Flp protein Flp_N PF03930.9 KOG96035.1 - 5.5e-28 96.5 0.7 1.1e-27 95.6 0.5 1.5 1 0 0 1 1 1 1 Recombinase Flp protein N-terminus Rep_4 PF05797.6 KOG96036.1 - 2.9e-97 325.4 0.0 3.6e-97 325.1 0.0 1.1 1 0 0 1 1 1 1 Yeast trans-acting factor (REP1/REP2) DUF1003 PF06210.6 KOG96038.1 - 0.088 12.7 0.4 0.19 11.6 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) MitoNEET_N PF10660.4 KOG96038.1 - 0.088 12.6 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus ATP-synt_C PF00137.16 KOG96039.1 - 9.2e-20 70.3 11.1 1e-19 70.1 7.7 1.0 1 0 0 1 1 1 1 ATP synthase subunit C ABC2_membrane_4 PF12730.2 KOG96039.1 - 0.25 10.4 8.3 0.31 10.1 5.7 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein VAR1 PF05316.7 KOG96040.1 - 3.4e-124 413.9 154.3 4.1e-124 413.7 107.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein (VAR1) COX2 PF00116.15 KOG96041.1 - 2.3e-52 175.8 0.0 3.3e-52 175.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain COX2_TM PF02790.10 KOG96041.1 - 6.2e-32 109.4 2.2 1.1e-31 108.5 1.5 1.4 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, transmembrane domain DUF2701 PF10857.3 KOG96041.1 - 4.2 7.2 6.2 6.8 6.5 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2701) COX3 PF00510.13 KOG96042.1 - 5.7e-113 376.6 26.9 6.4e-113 376.4 18.6 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit III Cytochrom_B_N_2 PF13631.1 KOG96043.1 - 5.1e-50 169.5 19.6 5.1e-50 169.5 13.6 3.2 3 1 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.12 KOG96043.1 - 2e-37 127.4 5.7 2e-37 127.4 4.0 4.0 2 1 2 4 4 4 1 Cytochrome b(C-terminal)/b6/petD Cytochrom_B_N PF00033.14 KOG96043.1 - 5.2e-14 52.0 19.3 5.2e-14 52.0 13.4 2.6 2 1 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB Ninjurin PF04923.7 KOG96043.1 - 3.2 7.5 6.7 0.2 11.3 0.1 2.5 3 0 0 3 3 3 0 Ninjurin COX1 PF00115.15 KOG96045.1 - 4.4e-167 556.2 55.4 5.3e-167 555.9 38.4 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I Fun_ATP-synt_8 PF05933.8 KOG96046.1 - 9.1e-22 76.8 13.8 9.8e-22 76.7 9.6 1.0 1 0 0 1 1 1 1 Fungal ATP synthase protein 8 (A6L) PsbT PF01405.12 KOG96046.1 - 0.12 12.0 2.4 0.18 11.4 1.7 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre T protein YMF19 PF02326.10 KOG96046.1 - 0.75 10.4 8.8 0.76 10.3 6.1 1.0 1 0 0 1 1 1 0 Plant ATP synthase F0 ATP-synt_A PF00119.15 KOG96047.1 - 1.7e-61 207.4 35.2 2e-61 207.1 24.4 1.0 1 0 0 1 1 1 1 ATP synthase A chain Sugar_tr PF00083.19 KOG96048.1 - 4.5e-79 266.1 12.7 5.2e-79 265.9 8.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.1 KOG96048.1 - 1.2e-05 23.9 0.8 1.2e-05 23.9 0.5 2.7 2 2 1 3 3 3 2 MFS/sugar transport protein MFS_1 PF07690.11 KOG96048.1 - 7.9e-05 21.5 21.7 0.0017 17.1 10.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.13 KOG96049.1 - 1e-19 70.4 6.5 1.6e-19 69.7 4.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG96049.1 - 1.4e-08 34.5 12.8 4.2e-08 32.9 8.9 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mac PF12464.3 KOG96051.1 - 1.6e-13 50.4 0.0 2.1e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.19 KOG96051.1 - 2.6e-13 48.8 21.3 1.5e-10 40.0 6.3 3.4 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 KOG96051.1 - 1.5e-09 37.2 17.8 4.4e-09 35.7 4.9 3.1 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase AA_permease PF00324.16 KOG96052.1 - 7.2e-103 344.4 40.9 8.2e-103 344.2 28.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG96052.1 - 9.8e-34 116.6 42.8 1.2e-33 116.3 29.7 1.0 1 0 0 1 1 1 1 Amino acid permease S-methyl_trans PF02574.11 KOG96053.1 - 3.3e-94 315.6 0.0 3.7e-94 315.4 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase RRM_DME PF15628.1 KOG96054.1 - 0.057 13.1 0.1 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 RRM in Demeter ATP-synt_Eps PF04627.8 KOG96055.1 - 1.6e-17 62.8 2.9 1.8e-17 62.5 2.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain ABC_membrane PF00664.18 KOG96056.1 - 5.6e-56 189.9 8.9 7.4e-56 189.5 6.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 KOG96056.1 - 1.9e-34 118.8 0.2 6.5e-34 117.1 0.0 2.1 2 0 0 2 2 2 1 ABC transporter AAA_5 PF07728.9 KOG96056.1 - 0.00074 19.2 0.1 0.026 14.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_21 PF13304.1 KOG96056.1 - 0.0018 18.2 0.7 1.8 8.4 0.0 3.2 2 1 0 3 3 3 1 AAA domain AAA_22 PF13401.1 KOG96056.1 - 0.0024 17.9 0.1 0.046 13.8 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOG96056.1 - 0.0031 17.5 0.6 0.037 14.0 0.1 2.7 2 2 0 2 2 2 1 AAA ATPase domain ABC_ATPase PF09818.4 KOG96056.1 - 0.0048 15.5 0.0 0.0099 14.4 0.0 1.5 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA PF00004.24 KOG96056.1 - 0.0069 16.5 0.0 0.047 13.8 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 KOG96056.1 - 0.009 15.4 0.0 2 7.7 0.0 3.0 2 1 1 3 3 3 1 IstB-like ATP binding protein AAA_17 PF13207.1 KOG96056.1 - 0.011 16.5 0.3 0.028 15.2 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_29 PF13555.1 KOG96056.1 - 0.019 14.4 0.0 0.067 12.7 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.1 KOG96056.1 - 0.024 14.0 0.0 0.18 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 KOG96056.1 - 0.04 13.1 0.0 0.084 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Ribosomal_60s PF00428.14 KOG96056.1 - 0.043 14.2 3.7 1 9.8 0.0 3.7 4 0 0 4 4 4 0 60s Acidic ribosomal protein AAA_14 PF13173.1 KOG96056.1 - 0.059 13.2 0.0 0.66 9.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain CDC45 PF02724.9 KOG96056.1 - 0.37 8.7 6.9 0.54 8.2 4.8 1.1 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.7 KOG96056.1 - 4.4 6.3 13.1 7.3 5.6 9.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PI-PLC-X PF00388.14 KOG96057.1 - 6.4e-50 168.3 0.2 3.1e-49 166.1 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 KOG96057.1 - 7.8e-37 125.8 1.9 9.4e-37 125.6 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_7 PF13499.1 KOG96057.1 - 4.8e-06 26.6 4.0 0.0015 18.6 0.1 2.8 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_like PF09279.6 KOG96057.1 - 0.00068 19.6 0.2 0.002 18.1 0.1 1.9 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_1 PF00036.27 KOG96057.1 - 0.00086 18.4 0.9 0.0084 15.3 0.1 2.8 2 0 0 2 2 2 1 EF hand C2 PF00168.25 KOG96057.1 - 0.0054 16.5 0.0 0.019 14.7 0.0 2.0 1 0 0 1 1 1 1 C2 domain EF-hand_5 PF13202.1 KOG96057.1 - 0.034 13.4 0.7 2.2 7.7 0.0 2.8 2 0 0 2 2 2 0 EF hand DUF3340 PF11818.3 KOG96058.1 - 0.11 12.4 0.6 0.17 11.8 0.4 1.3 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) RrnaAD PF00398.15 KOG96059.1 - 5.7e-69 232.0 0.0 6.7e-69 231.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 KOG96059.1 - 1.3e-11 44.5 0.0 2e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOG96059.1 - 1.6e-06 28.6 0.0 2.5e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 KOG96059.1 - 3.9e-05 23.3 0.0 6.5e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_11 PF08241.7 KOG96059.1 - 6.7e-05 23.2 0.0 0.00013 22.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOG96059.1 - 8e-05 22.0 0.0 0.00014 21.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 KOG96059.1 - 0.00011 21.8 0.0 0.00017 21.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 KOG96059.1 - 0.00033 19.8 0.0 0.00099 18.2 0.0 1.6 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_31 PF13847.1 KOG96059.1 - 0.00051 19.6 0.0 0.00089 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOG96059.1 - 0.0016 18.1 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOG96059.1 - 0.0034 17.8 0.0 0.0084 16.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 KOG96059.1 - 0.01 15.0 0.1 0.034 13.3 0.0 1.9 3 0 0 3 3 3 0 O-methyltransferase Ubie_methyltran PF01209.13 KOG96059.1 - 0.02 14.0 0.3 0.077 12.1 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family PRMT5 PF05185.11 KOG96059.1 - 0.027 13.3 0.2 0.21 10.4 0.0 2.0 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase UPF0020 PF01170.13 KOG96059.1 - 0.068 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 UPF0158 PF03682.8 KOG96059.1 - 0.13 11.8 0.4 0.24 10.9 0.1 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0158) AA_permease PF00324.16 KOG96060.1 - 9.1e-120 400.2 46.3 1.1e-119 399.9 32.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG96060.1 - 2.5e-34 118.5 46.8 3.2e-34 118.2 32.5 1.1 1 0 0 1 1 1 1 Amino acid permease EamA PF00892.15 KOG96061.1 - 4.3e-26 91.4 27.2 7.9e-15 55.0 5.4 2.6 2 1 1 3 3 3 2 EamA-like transporter family EmrE PF13536.1 KOG96061.1 - 5.2e-09 36.2 4.3 5.2e-09 36.2 3.0 3.4 2 1 0 3 3 3 1 Multidrug resistance efflux transporter UAA PF08449.6 KOG96061.1 - 0.00062 18.7 18.3 0.0071 15.3 2.9 2.5 1 1 1 2 2 2 2 UAA transporter family RseC_MucC PF04246.7 KOG96061.1 - 0.75 9.3 6.7 1.1 8.8 0.2 3.2 2 1 1 3 3 3 0 Positive regulator of sigma(E), RseC/MucC Kelch_3 PF13415.1 KOG96062.1 - 7.4e-30 102.4 2.8 4.5e-09 36.2 0.1 7.1 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_4 PF13418.1 KOG96062.1 - 2.4e-27 94.4 6.1 2.1e-06 27.3 0.2 7.0 5 2 1 6 6 6 5 Galactose oxidase, central domain DUF4110 PF13422.1 KOG96062.1 - 1.1e-22 79.6 0.7 1.1e-22 79.6 0.5 3.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4110) Kelch_6 PF13964.1 KOG96062.1 - 1.2e-17 63.2 12.9 8.2e-06 25.7 0.1 6.5 4 2 2 6 6 6 6 Kelch motif Kelch_5 PF13854.1 KOG96062.1 - 4.1e-16 58.5 7.8 0.00035 20.4 0.1 6.3 6 1 0 6 6 6 4 Kelch motif Kelch_1 PF01344.20 KOG96062.1 - 4.7e-14 51.6 12.6 7.1e-05 22.2 0.1 6.5 6 1 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 KOG96062.1 - 2.5e-12 46.0 12.0 0.00015 21.3 0.0 5.8 6 0 0 6 6 6 3 Kelch motif Lyase_1 PF00206.15 KOG96063.1 - 8.4e-121 402.9 0.0 1.2e-120 402.4 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.4 KOG96063.1 - 5.6e-26 90.3 0.0 1.1e-25 89.3 0.0 1.5 1 0 0 1 1 1 1 Fumarase C C-terminus ADH_N PF08240.7 KOG96063.1 - 0.037 13.7 0.0 0.092 12.5 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain DUF2408 PF10303.4 KOG96064.1 - 1.3e-77 258.4 23.5 6.5e-51 171.9 4.4 5.1 2 2 3 5 5 5 4 Protein of unknown function (DUF2408) Cep57_MT_bd PF06657.8 KOG96064.1 - 0.09 12.7 5.2 0.37 10.7 0.0 3.7 4 0 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 Adap_comp_sub PF00928.16 KOG96065.1 - 4.3e-88 294.8 0.4 5.5e-88 294.4 0.3 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 KOG96065.1 - 1.4e-08 34.6 0.1 2.6e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Phos_pyr_kin PF08543.7 KOG96066.1 - 2.4e-78 262.7 0.1 3e-78 262.4 0.1 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.11 KOG96066.1 - 4.3e-70 235.7 0.0 6.1e-70 235.2 0.0 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.19 KOG96066.1 - 5e-06 25.8 0.0 7.8e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Cyclin_N PF00134.18 KOG96067.1 - 1.3e-42 144.3 0.0 2.6e-42 143.3 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain BBP1_C PF15272.1 KOG96068.1 - 6.7e-54 182.4 28.7 1.2e-53 181.6 19.9 1.4 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal BBP1_N PF15271.1 KOG96068.1 - 1.4e-44 151.9 0.5 1.4e-44 151.9 0.4 2.8 2 1 0 3 3 3 1 Spindle pole body component BBP1, Mps2-binding protein Tox-PLDMTX PF15645.1 KOG96068.1 - 0.036 14.0 1.3 0.071 13.1 0.9 1.4 1 0 0 1 1 1 0 Dermonecrotoxin of the Papain-like fold Tup_N PF08581.5 KOG96068.1 - 0.14 12.3 18.7 1.5 9.0 3.6 2.9 1 1 1 2 2 2 0 Tup N-terminal TMA7 PF09072.5 KOG96068.1 - 2.2 8.8 6.7 2.9 8.4 0.2 2.7 2 0 0 2 2 2 0 Translation machinery associated TMA7 SAGA-Tad1 PF12767.2 KOG96069.1 - 7.4e-77 258.4 0.5 1.3e-76 257.6 0.3 1.4 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.9 KOG96069.1 - 0.00014 21.2 0.0 0.00024 20.4 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family TFIID_30kDa PF03540.8 KOG96069.1 - 0.16 11.7 0.0 0.38 10.6 0.0 1.6 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit Reo_sigmaC PF04582.7 KOG96070.1 - 0.049 12.8 13.5 0.026 13.7 5.5 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF1843 PF08898.5 KOG96070.1 - 0.17 11.9 0.1 0.17 11.9 0.0 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF1843) PilJ PF13675.1 KOG96070.1 - 0.18 12.1 15.4 0.2 11.9 1.6 2.8 1 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF1515 PF07439.6 KOG96070.1 - 0.83 9.4 6.2 0.18 11.6 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1515) Fer2 PF00111.22 KOG96071.1 - 1.1e-12 47.5 1.4 1.4e-12 47.1 1.0 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Ribosomal_L36e PF01158.13 KOG96073.1 - 2.7e-30 104.2 1.8 2.8e-30 104.1 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e RabGAP-TBC PF00566.13 KOG96074.1 - 2.1e-51 174.4 0.1 2.1e-51 174.4 0.0 2.8 3 0 0 3 3 3 1 Rab-GTPase-TBC domain Lebercilin PF15619.1 KOG96074.1 - 0.53 9.6 26.9 0.049 13.0 15.1 1.9 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease bZIP_1 PF00170.16 KOG96074.1 - 3.1 7.8 10.7 7.8 6.5 1.1 3.4 2 0 0 2 2 2 0 bZIP transcription factor DivIC PF04977.10 KOG96074.1 - 6.5 6.3 16.2 0.84 9.1 0.9 3.2 3 0 0 3 3 3 0 Septum formation initiator Fungal_trans PF04082.13 KOG96075.1 - 1.3e-26 93.0 10.3 1.3e-26 93.0 7.1 1.9 2 1 0 2 2 2 1 Fungal specific transcription factor domain Gal4_dimer PF03902.8 KOG96075.1 - 1.8e-18 66.1 1.5 3.9e-18 65.1 1.0 1.5 1 0 0 1 1 1 1 Gal4-like dimerisation domain Zn_clus PF00172.13 KOG96075.1 - 1.5e-08 34.4 19.4 2.5e-08 33.7 13.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain WD40 PF00400.27 KOG96076.1 - 1.4e-19 69.1 15.9 7.8e-08 31.9 0.1 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat Rhomboid PF01694.17 KOG96077.1 - 3.1e-22 79.1 11.9 3.1e-22 79.1 8.2 1.4 2 0 0 2 2 2 1 Rhomboid family DUF2075 PF09848.4 KOG96078.1 - 5.5e-106 354.5 0.0 6.5e-106 354.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 KOG96078.1 - 1.3e-07 31.8 0.0 4.5e-07 30.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 KOG96078.1 - 0.00035 20.7 0.0 0.00073 19.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOG96078.1 - 0.00039 20.4 0.0 0.00067 19.6 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain ResIII PF04851.10 KOG96078.1 - 0.002 17.9 0.0 1.4 8.7 0.0 2.3 1 1 1 2 2 2 2 Type III restriction enzyme, res subunit AAA_30 PF13604.1 KOG96078.1 - 0.0067 16.0 0.0 0.047 13.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain VirE PF05272.6 KOG96078.1 - 0.0087 15.5 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 Virulence-associated protein E DUF258 PF03193.11 KOG96078.1 - 0.016 14.3 0.0 0.031 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NACHT PF05729.7 KOG96078.1 - 0.021 14.4 0.0 0.046 13.3 0.0 1.7 1 1 0 1 1 1 0 NACHT domain Bac_DnaA PF00308.13 KOG96078.1 - 0.022 14.3 0.4 0.39 10.3 0.3 2.3 2 0 0 2 2 2 0 Bacterial dnaA protein T2SE PF00437.15 KOG96078.1 - 0.026 13.4 0.0 0.042 12.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.1 KOG96078.1 - 0.028 14.7 0.1 0.93 9.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 KOG96078.1 - 0.038 13.8 0.1 0.11 12.3 0.1 1.8 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOG96078.1 - 0.055 13.6 0.0 0.48 10.6 0.0 2.6 2 1 0 2 2 2 0 RNA helicase DAP3 PF10236.4 KOG96078.1 - 0.069 12.0 0.0 0.16 10.8 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_19 PF13245.1 KOG96078.1 - 0.12 12.1 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain Sigma54_activat PF00158.21 KOG96078.1 - 0.16 11.4 0.0 0.34 10.3 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain UAA PF08449.6 KOG96079.1 - 7e-92 307.5 14.8 7.9e-92 307.3 10.3 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOG96079.1 - 9.2e-08 31.8 10.3 9.2e-08 31.8 7.1 2.4 2 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 KOG96079.1 - 2.7e-07 30.6 8.7 2.7e-07 30.6 6.0 3.0 3 0 0 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.10 KOG96079.1 - 7.6e-05 21.9 5.4 0.11 11.6 0.3 2.4 1 1 1 2 2 2 2 Nucleotide-sugar transporter EmrE PF13536.1 KOG96079.1 - 0.0094 16.1 9.7 0.0094 16.1 6.7 3.0 2 1 1 3 3 3 2 Multidrug resistance efflux transporter L31 PF09784.4 KOG96080.1 - 8.2 6.5 8.9 2.5 8.2 1.2 3.1 3 0 0 3 3 3 0 Mitochondrial ribosomal protein L31 RasGAP_C PF03836.10 KOG96081.1 - 4.5e-34 117.1 2.7 4.5e-34 117.1 1.9 2.0 2 0 0 2 2 2 1 RasGAP C-terminus RasGAP PF00616.14 KOG96081.1 - 1.1e-23 83.9 0.6 3.7e-23 82.2 0.4 2.0 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase CH PF00307.26 KOG96081.1 - 1.3e-08 34.8 0.0 1.3e-07 31.5 0.0 2.9 2 0 0 2 2 2 1 Calponin homology (CH) domain IQ PF00612.22 KOG96081.1 - 1.3e-07 30.5 20.6 0.055 13.1 0.5 8.7 9 0 0 9 9 9 3 IQ calmodulin-binding motif XkdW PF09636.5 KOG96081.1 - 0.014 15.2 0.2 0.74 9.7 0.0 2.8 2 0 0 2 2 2 0 XkdW protein DUF972 PF06156.8 KOG96081.1 - 0.015 15.6 1.1 0.066 13.5 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF972) TBCC PF07986.7 KOG96082.1 - 0.00016 21.0 1.8 0.00066 19.0 1.3 2.0 1 1 0 1 1 1 1 Tubulin binding cofactor C HSP90 PF00183.13 KOG96083.1 - 5.8e-256 850.0 38.2 6.7e-256 849.7 26.5 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.21 KOG96083.1 - 8.1e-11 41.6 0.0 1.5e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 KOG96083.1 - 1e-10 41.3 0.0 3.8e-10 39.5 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase KCl_Cotrans_1 PF03522.10 KOG96083.1 - 0.03 13.8 0.2 0.097 12.2 0.1 1.9 1 0 0 1 1 1 0 K-Cl Co-transporter type 1 (KCC1) Peptidase_S10 PF00450.17 KOG96083.1 - 0.087 11.9 1.1 0.18 10.8 0.0 1.9 1 1 1 2 2 2 0 Serine carboxypeptidase Ank_2 PF12796.2 KOG96084.1 - 1.9e-23 82.5 0.9 1.5e-15 57.2 0.1 1.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOG96084.1 - 1.2e-16 60.6 0.1 1.7e-11 44.3 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOG96084.1 - 1.8e-15 56.6 0.2 1.2e-08 34.9 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOG96084.1 - 4.1e-15 54.7 0.1 4.3e-08 32.5 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.1 KOG96084.1 - 1e-11 43.8 0.1 0.00019 21.3 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat PqqD PF05402.7 KOG96084.1 - 0.13 12.3 2.2 3.2 7.8 0.1 2.9 2 1 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) eIF-5_eIF-2B PF01873.12 KOG96085.1 - 4e-46 155.7 0.1 6.6e-46 155.0 0.1 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 IF2_N PF04760.10 KOG96085.1 - 0.00068 19.2 0.9 0.018 14.6 0.0 3.1 3 0 0 3 3 3 1 Translation initiation factor IF-2, N-terminal region TF_Zn_Ribbon PF08271.7 KOG96085.1 - 0.073 12.4 0.2 0.14 11.5 0.1 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding DUF2413 PF10310.4 KOG96085.1 - 4.1 6.1 10.3 5.7 5.6 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Pkinase PF00069.20 KOG96086.1 - 1.8e-37 128.8 0.0 9.5e-37 126.5 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96086.1 - 6.2e-17 61.5 0.0 1.4e-16 60.3 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase WHIM3 PF15614.1 KOG96086.1 - 0.088 12.6 0.0 0.42 10.4 0.0 2.1 2 0 0 2 2 2 0 WSTF, HB1, Itc1p, MBD9 motif 3 TIP49 PF06068.8 KOG96087.1 - 6e-180 598.1 4.0 7.3e-180 597.9 2.8 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 KOG96087.1 - 9.3e-09 35.5 0.7 1.5e-05 25.2 0.1 2.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOG96087.1 - 4.5e-07 29.1 2.9 0.0004 19.5 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus DnaB_C PF03796.10 KOG96087.1 - 1.8e-05 23.7 0.8 3.2e-05 22.9 0.1 1.8 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_16 PF13191.1 KOG96087.1 - 6e-05 23.1 0.0 0.00066 19.7 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 KOG96087.1 - 9.7e-05 22.5 1.8 0.079 13.1 0.0 2.8 2 1 1 3 3 3 2 AAA domain AAA_5 PF07728.9 KOG96087.1 - 0.012 15.3 0.2 3.2 7.4 0.0 2.9 2 2 0 2 2 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 KOG96087.1 - 0.017 14.3 0.7 0.37 9.9 0.1 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 KOG96087.1 - 0.019 14.7 0.2 0.041 13.6 0.2 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_25 PF13481.1 KOG96087.1 - 0.036 13.4 0.8 0.08 12.3 0.2 1.8 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 KOG96087.1 - 0.053 12.9 0.0 8.5 5.8 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain Sipho_tail PF05709.6 KOG96087.1 - 0.055 12.6 0.1 0.1 11.7 0.1 1.4 1 0 0 1 1 1 0 Phage tail protein AAA_28 PF13521.1 KOG96087.1 - 0.077 12.9 0.1 0.24 11.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain CBFD_NFYB_HMF PF00808.18 KOG96087.1 - 0.09 12.8 0.2 0.31 11.1 0.2 2.0 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone ATP-synt_C PF00137.16 KOG96088.1 - 4.5e-28 96.9 27.3 5.9e-15 54.9 2.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Polysacc_synt_3 PF13440.1 KOG96088.1 - 0.18 11.2 8.2 0.018 14.4 2.0 1.9 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Mis14 PF08641.7 KOG96089.1 - 2.1e-39 134.7 6.1 2.1e-39 134.7 4.3 2.1 2 0 0 2 2 2 1 Kinetochore protein Mis14 like Gemini_AL1_M PF08283.6 KOG96089.1 - 0.0037 17.0 0.4 0.0096 15.7 0.3 1.8 1 1 0 1 1 1 1 Geminivirus rep protein central domain DUF4598 PF15370.1 KOG96089.1 - 0.27 11.5 5.6 0.1 12.9 1.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4598) TPR_MLP1_2 PF07926.7 KOG96089.1 - 4.7 6.9 10.7 0.078 12.7 1.0 2.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein SNARE PF05739.14 KOG96090.1 - 3.7e-16 58.5 6.0 3.7e-16 58.5 4.2 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 KOG96090.1 - 4.6e-09 36.3 3.5 4.6e-09 36.3 2.5 2.4 2 0 0 2 2 2 1 Syntaxin Synaptobrevin PF00957.16 KOG96090.1 - 0.00013 21.4 2.3 0.00013 21.4 1.6 2.4 2 0 0 2 2 2 1 Synaptobrevin Rifin_STEVOR PF02009.11 KOG96090.1 - 0.0039 16.8 3.4 0.0039 16.8 2.4 1.6 1 1 1 2 2 2 1 Rifin/stevor family DUF2277 PF10041.4 KOG96090.1 - 0.018 14.9 0.7 7.1 6.6 0.6 2.8 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2277) Baculo_PEP_C PF04513.7 KOG96090.1 - 0.023 14.4 2.4 0.49 10.2 0.0 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.7 KOG96090.1 - 0.029 13.5 2.3 1.5 7.9 0.1 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein T2SF PF00482.18 KOG96090.1 - 0.052 13.4 2.8 0.17 11.7 2.0 1.9 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF3753 PF12575.3 KOG96090.1 - 0.085 12.6 0.3 0.085 12.6 0.2 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF3753) DUF2407 PF10302.4 KOG96090.1 - 0.11 12.6 1.3 0.22 11.7 0.9 1.6 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain BLOC1_2 PF10046.4 KOG96090.1 - 0.24 11.5 9.2 1.9 8.6 0.1 3.2 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4094 PF13334.1 KOG96090.1 - 0.34 11.3 0.2 0.34 11.3 0.1 2.8 2 1 2 4 4 4 0 Domain of unknown function (DUF4094) DUF4179 PF13786.1 KOG96090.1 - 1.1 9.5 5.0 13 6.0 0.8 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4179) MacB_PCD PF12704.2 KOG96090.1 - 1.5 8.3 5.2 1.6 8.2 1.0 2.2 2 0 0 2 2 2 0 MacB-like periplasmic core domain Fic PF02661.13 KOG96090.1 - 1.6 9.4 4.0 15 6.3 0.1 2.9 1 1 1 2 2 2 0 Fic/DOC family DUF2116 PF09889.4 KOG96090.1 - 2.2 8.1 6.0 0.46 10.3 0.7 2.2 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Allexi_40kDa PF05549.6 KOG96090.1 - 4.7 6.4 10.4 0.75 9.0 1.2 2.1 1 1 0 2 2 2 0 Allexivirus 40kDa protein ketoacyl-synt PF00109.21 KOG96091.1 - 1.2e-18 67.5 0.0 3.4e-18 66.0 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.15 KOG96091.1 - 3.4e-16 59.0 0.0 8.5e-16 57.8 0.0 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.17 KOG96091.1 - 1.4e-12 47.5 0.1 8.2e-12 45.0 0.0 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.20 KOG96091.1 - 3.5e-05 23.7 0.0 3.5e-05 23.7 0.0 2.2 3 0 0 3 3 3 1 short chain dehydrogenase KR PF08659.5 KOG96091.1 - 0.0014 18.3 0.0 0.0046 16.6 0.0 1.8 1 0 0 1 1 1 1 KR domain zf-H2C2_2 PF13465.1 KOG96092.1 - 7e-10 38.7 2.2 7e-10 38.7 1.5 2.4 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOG96092.1 - 2.9e-09 36.6 6.2 0.00029 20.9 0.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 KOG96092.1 - 5e-09 35.9 7.0 0.00038 20.6 0.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type Caldesmon PF02029.10 KOG96092.1 - 0.0018 16.8 1.6 0.0029 16.1 1.1 1.3 1 0 0 1 1 1 1 Caldesmon zf-H2C2_5 PF13909.1 KOG96092.1 - 0.051 13.8 4.5 0.08 13.2 0.3 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain SR-25 PF10500.4 KOG96092.1 - 0.61 9.5 19.7 0.083 12.3 10.1 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF2217 PF10265.4 KOG96092.1 - 0.71 8.5 4.5 1 8.0 3.2 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) zf-C2H2_jaz PF12171.3 KOG96092.1 - 1.6 8.9 4.8 0.48 10.6 0.4 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding mRNA_triPase PF02940.10 KOG96094.1 - 3e-60 203.6 0.3 3e-60 203.6 0.2 1.7 2 0 0 2 2 2 1 mRNA capping enzyme, beta chain Glycos_transf_2 PF00535.21 KOG96095.1 - 4.9e-26 91.4 0.0 6.5e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KOG96095.1 - 4.4e-06 26.6 0.0 8.1e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 KOG96095.1 - 0.00047 19.3 0.0 0.00063 18.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 KOG96095.1 - 0.15 12.4 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 ABC_tran PF00005.22 KOG96096.1 - 5.1e-48 162.8 0.0 8.4e-25 87.6 0.0 3.9 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 KOG96096.1 - 2.9e-13 50.4 12.8 5.5e-05 23.2 0.1 4.9 3 2 0 3 3 3 2 AAA domain SMC_N PF02463.14 KOG96096.1 - 2.8e-12 46.3 0.0 0.0013 17.9 0.0 3.7 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain Chromo PF00385.19 KOG96096.1 - 7.5e-10 38.3 1.2 1.7e-09 37.1 0.9 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_29 PF13555.1 KOG96096.1 - 2.1e-07 30.3 0.1 0.015 14.7 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 KOG96096.1 - 4.5e-06 25.9 0.0 0.022 13.9 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 KOG96096.1 - 6.9e-06 26.8 1.3 0.062 14.1 0.0 3.6 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.18 KOG96096.1 - 8.9e-06 25.6 0.0 0.1 12.5 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.1 KOG96096.1 - 9.2e-06 25.8 0.0 0.087 12.9 0.0 3.2 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 KOG96096.1 - 1e-05 25.9 12.1 0.019 15.2 0.0 4.3 4 0 0 4 4 4 2 AAA domain AAA_10 PF12846.2 KOG96096.1 - 2.4e-05 23.9 2.9 0.72 9.2 0.0 4.5 5 0 0 5 5 5 2 AAA-like domain Miro PF08477.8 KOG96096.1 - 0.0003 21.2 0.0 1.3 9.5 0.0 2.9 2 0 0 2 2 2 2 Miro-like protein AAA_33 PF13671.1 KOG96096.1 - 0.00035 20.4 0.0 1 9.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 KOG96096.1 - 0.00067 19.5 0.4 1.9 8.4 0.0 3.8 2 2 1 3 3 3 1 Putative exonuclease SbcCD, C subunit ArgK PF03308.11 KOG96096.1 - 0.00088 18.1 0.5 0.79 8.4 0.0 2.7 3 0 0 3 3 3 2 ArgK protein RNA_helicase PF00910.17 KOG96096.1 - 0.00091 19.3 0.2 3.5 7.8 0.0 3.3 4 0 0 4 4 2 2 RNA helicase AAA_18 PF13238.1 KOG96096.1 - 0.00094 19.4 0.7 0.5 10.6 0.1 3.0 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 KOG96096.1 - 0.0014 18.3 0.0 0.89 9.2 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 KOG96096.1 - 0.0015 18.1 0.3 2.5 7.6 0.2 3.4 3 1 0 3 3 2 1 AAA domain NACHT PF05729.7 KOG96096.1 - 0.0032 17.1 0.1 0.89 9.1 0.0 3.1 2 0 0 2 2 2 1 NACHT domain AAA PF00004.24 KOG96096.1 - 0.0041 17.3 0.0 4 7.6 0.0 3.0 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 KOG96096.1 - 0.0051 16.7 0.0 2.4 8.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.12 KOG96096.1 - 0.011 15.6 3.8 0.7 9.6 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function DUF87 Zeta_toxin PF06414.7 KOG96096.1 - 0.016 14.3 0.3 12 4.9 0.0 3.3 3 0 0 3 3 3 0 Zeta toxin AAA_16 PF13191.1 KOG96096.1 - 0.017 15.1 0.2 1.9 8.4 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain Dynamin_N PF00350.18 KOG96096.1 - 0.024 14.4 1.4 2.9 7.6 0.0 3.8 3 1 0 3 3 2 0 Dynamin family Thymidylate_kin PF02223.12 KOG96096.1 - 0.054 12.8 0.2 0.79 9.0 0.0 2.6 2 0 0 2 2 2 0 Thymidylate kinase HEAT PF02985.17 KOG96096.1 - 0.28 11.3 1.4 4.4 7.6 0.0 3.6 4 0 0 4 4 4 0 HEAT repeat Polysacc_synt_4 PF04669.8 KOG96097.1 - 1.7e-21 76.4 1.8 1.3e-20 73.5 1.2 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis CBAH PF02275.13 KOG96097.1 - 0.017 14.5 0.3 0.023 14.1 0.2 1.1 1 0 0 1 1 1 0 Linear amide C-N hydrolases, choloylglycine hydrolase family DUF4391 PF14335.1 KOG96097.1 - 0.031 13.6 0.5 0.041 13.2 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) YcbB PF08664.5 KOG96097.1 - 0.11 12.2 1.0 0.19 11.5 0.7 1.3 1 0 0 1 1 1 0 YcbB domain Cation_efflux PF01545.16 KOG96098.1 - 7.4e-49 166.3 4.3 9.4e-49 165.9 3.0 1.1 1 0 0 1 1 1 1 Cation efflux family UPF0061 PF02696.9 KOG96100.1 - 1.4e-212 706.2 1.0 1.6e-212 706.1 0.7 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family E2_bind PF08825.5 KOG96100.1 - 0.035 13.8 0.0 0.1 12.3 0.0 1.8 1 0 0 1 1 1 0 E2 binding domain TRP PF06011.7 KOG96102.1 - 1.7e-150 501.4 35.3 1.7e-150 501.4 24.5 1.5 2 0 0 2 2 2 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 KOG96102.1 - 2.9e-43 147.3 1.3 4.7e-43 146.6 0.9 1.3 1 0 0 1 1 1 1 ML-like domain E1_DerP2_DerF2 PF02221.10 KOG96102.1 - 0.0036 17.5 0.1 0.006 16.8 0.0 1.4 1 0 0 1 1 1 1 ML domain Ribosomal_L1 PF00687.16 KOG96103.1 - 5.2e-44 150.2 1.9 6.4e-44 149.9 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Cyclin PF08613.6 KOG96104.1 - 3.5e-16 59.9 0.3 3.5e-16 59.9 0.2 2.1 2 0 0 2 2 2 1 Cyclin DUF663 PF04950.7 KOG96105.1 - 2.7e-107 358.1 0.9 2.7e-107 358.1 0.6 2.5 2 0 0 2 2 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 KOG96105.1 - 1.1e-28 98.5 0.0 3.3e-28 97.0 0.0 1.9 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.22 KOG96105.1 - 2.2e-07 30.5 2.3 1.4e-05 24.6 0.0 3.0 2 1 0 2 2 1 1 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 KOG96105.1 - 1.2e-05 26.1 0.0 1.2e-05 26.1 0.0 3.8 3 1 1 4 4 3 1 AAA domain AAA_33 PF13671.1 KOG96105.1 - 1.4e-05 25.0 0.1 0.00018 21.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 KOG96105.1 - 2e-05 24.8 0.0 5.7e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MobB PF03205.9 KOG96105.1 - 5.8e-05 22.8 0.0 0.00019 21.1 0.0 2.0 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 KOG96105.1 - 0.00012 22.0 0.0 0.00031 20.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 KOG96105.1 - 0.00019 21.5 0.0 0.00057 20.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOG96105.1 - 0.00027 20.6 0.1 0.00063 19.4 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain Miro PF08477.8 KOG96105.1 - 0.00034 21.0 0.2 0.0025 18.2 0.0 2.7 2 0 0 2 2 1 1 Miro-like protein NACHT PF05729.7 KOG96105.1 - 0.00091 18.9 0.1 0.0031 17.2 0.1 1.8 1 1 0 1 1 1 1 NACHT domain AAA_28 PF13521.1 KOG96105.1 - 0.0029 17.5 0.0 0.011 15.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 KOG96105.1 - 0.0037 17.1 0.0 0.013 15.4 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.1 KOG96105.1 - 0.0052 17.0 0.0 0.0052 17.0 0.0 4.8 4 2 0 4 4 3 1 AAA domain AAA_25 PF13481.1 KOG96105.1 - 0.007 15.7 0.0 0.022 14.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 KOG96105.1 - 0.0078 16.3 0.0 0.025 14.7 0.0 1.9 1 0 0 1 1 1 1 RNA helicase NTPase_1 PF03266.10 KOG96105.1 - 0.0099 15.5 0.3 0.022 14.4 0.2 1.6 1 0 0 1 1 1 1 NTPase ABC_tran PF00005.22 KOG96105.1 - 0.012 15.8 0.0 0.012 15.8 0.0 2.5 3 0 0 3 3 1 0 ABC transporter cobW PF02492.14 KOG96105.1 - 0.017 14.5 0.1 0.035 13.5 0.1 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.9 KOG96105.1 - 0.02 14.6 0.0 0.045 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.4 KOG96105.1 - 0.022 14.2 0.0 0.44 10.0 0.0 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_11 PF13086.1 KOG96105.1 - 0.037 13.6 0.0 0.037 13.6 0.0 3.8 3 1 0 3 3 2 0 AAA domain WAC_Acf1_DNA_bd PF10537.4 KOG96106.1 - 5.7e-30 103.4 0.4 2.7e-29 101.3 0.3 2.3 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal WHIM2 PF15613.1 KOG96106.1 - 1.2e-09 37.7 3.5 5.9e-09 35.5 2.4 2.3 1 1 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 2 DDT PF02791.12 KOG96106.1 - 7.7e-09 35.1 0.8 4.9e-07 29.4 0.1 2.8 3 0 0 3 3 3 1 DDT domain WHIM1 PF15612.1 KOG96106.1 - 0.051 13.5 0.1 0.051 13.5 0.0 2.1 2 0 0 2 2 2 0 WSTF, HB1, Itc1p, MBD9 motif 1 Ubiq_cyt_C_chap PF03981.7 KOG96107.1 - 2e-41 141.1 0.1 2.9e-41 140.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone HK PF02110.10 KOG96108.1 - 3.4e-95 317.8 0.7 6.4e-95 316.9 0.5 1.4 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.12 KOG96108.1 - 3e-57 192.6 0.0 4.3e-57 192.1 0.0 1.2 1 0 0 1 1 1 1 Thiamine monophosphate synthase/TENI LRR_9 PF14580.1 KOG96109.1 - 4.8e-10 39.2 1.0 7e-10 38.7 0.7 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.2 KOG96109.1 - 0.00013 21.5 15.7 0.00075 19.0 0.9 3.7 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOG96109.1 - 0.25 11.5 16.8 4.9 7.5 0.2 5.3 5 1 1 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.1 KOG96109.1 - 0.26 11.0 14.1 0.55 10.0 5.2 3.2 1 1 2 3 3 3 0 Leucine rich repeat FNIP PF05725.7 KOG96109.1 - 0.37 10.7 1.8 42 4.2 0.0 3.0 2 1 0 2 2 2 0 FNIP Repeat LRR_7 PF13504.1 KOG96109.1 - 4.6 7.8 17.0 0.85 10.0 0.2 5.4 5 1 0 5 5 5 0 Leucine rich repeat PseudoU_synth_1 PF01416.15 KOG96110.1 - 1.8e-20 73.2 0.0 9.2e-09 35.6 0.0 2.6 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF2344 PF10105.4 KOG96110.1 - 0.19 11.1 0.0 0.19 11.1 0.0 2.4 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2344) UPF0113 PF03657.8 KOG96111.1 - 3.7e-13 49.4 0.0 4.5e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0113) SRP72 PF08492.7 KOG96112.1 - 1.4e-12 47.8 7.5 1.4e-12 47.8 5.2 2.5 2 0 0 2 2 1 1 SRP72 RNA-binding domain TPR_2 PF07719.12 KOG96112.1 - 3.9e-07 29.4 6.0 0.019 14.8 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOG96112.1 - 4.2e-07 29.8 3.8 0.00023 21.0 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOG96112.1 - 2.9e-05 23.6 3.1 0.023 14.3 0.0 3.8 4 0 0 4 4 4 2 TPR repeat TPR_19 PF14559.1 KOG96112.1 - 5.1e-05 23.5 2.2 0.017 15.4 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOG96112.1 - 0.00015 22.1 0.0 1.4 9.7 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOG96112.1 - 0.0027 17.3 0.1 0.0027 17.3 0.1 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat Apc3 PF12895.2 KOG96112.1 - 0.011 15.8 15.7 2 8.6 1.0 4.7 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Clathrin PF00637.15 KOG96112.1 - 0.016 14.7 11.5 0.76 9.3 0.2 4.6 4 2 1 5 5 5 0 Region in Clathrin and VPS TPR_5 PF12688.2 KOG96112.1 - 0.017 15.1 0.2 0.37 10.8 0.0 2.8 3 0 0 3 3 3 0 Tetratrico peptide repeat TPR_7 PF13176.1 KOG96112.1 - 0.032 14.0 3.3 0.26 11.1 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOG96112.1 - 0.033 13.8 7.9 0.7 9.6 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Isochorismatase PF00857.15 KOG96112.1 - 0.043 13.7 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 Isochorismatase family TPR_6 PF13174.1 KOG96112.1 - 0.13 12.7 5.2 42 4.8 0.0 5.1 5 0 0 5 5 4 0 Tetratricopeptide repeat Pkinase PF00069.20 KOG96113.1 - 1.4e-70 237.4 0.1 1.7e-70 237.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96113.1 - 1.3e-46 158.7 0.0 1.8e-46 158.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG96113.1 - 1.5e-05 24.1 0.0 0.00022 20.2 0.0 2.2 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOG96113.1 - 0.024 13.6 0.0 0.05 12.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SET PF00856.23 KOG96114.1 - 0.00021 21.6 0.2 0.00069 19.9 0.0 1.9 2 0 0 2 2 2 1 SET domain Radical_SAM PF04055.16 KOG96115.1 - 2.6e-23 83.0 0.0 5.8e-23 81.8 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.7 KOG96115.1 - 1.1e-20 73.4 0.0 3.1e-20 72.0 0.0 1.8 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.20 KOG96115.1 - 6.1e-14 52.2 0.0 1.4e-13 51.1 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin GDPD PF03009.12 KOG96116.1 - 1.5e-42 145.8 0.0 1.8e-42 145.6 0.0 1.0 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.1 KOG96116.1 - 0.00061 19.8 0.1 0.013 15.6 0.0 2.5 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Pkinase PF00069.20 KOG96117.1 - 1.9e-41 141.9 0.0 3.6e-41 141.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96117.1 - 6.5e-14 51.6 0.0 1.3e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOG96117.1 - 0.012 15.3 1.9 0.085 12.5 0.0 2.7 3 0 0 3 3 3 0 Phosphotransferase enzyme family Pkinase PF00069.20 KOG96118.1 - 7.2e-71 238.3 0.6 9.2e-71 238.0 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96118.1 - 3.3e-40 137.8 0.0 4.7e-40 137.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG96118.1 - 2.8e-05 23.2 0.2 5.2e-05 22.3 0.0 1.7 2 1 0 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.4 KOG96118.1 - 0.044 13.1 0.2 0.23 10.7 0.0 2.2 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.6 KOG96118.1 - 0.086 11.6 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.18 KOG96118.1 - 0.41 10.3 2.4 0.42 10.2 0.0 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family AFT PF08731.6 KOG96119.1 - 2.7e-34 117.7 7.3 7.7e-20 71.1 0.2 2.7 2 1 1 3 3 3 2 Transcription factor AFT DBD_Tnp_Mut PF03108.10 KOG96119.1 - 0.00022 20.7 0.1 0.0021 17.6 0.0 2.4 1 1 0 1 1 1 1 MuDR family transposase USP8_dimer PF08969.6 KOG96119.1 - 0.077 12.9 0.7 0.077 12.9 0.5 1.8 2 0 0 2 2 2 0 USP8 dimerisation domain DUF1771 PF08590.5 KOG96122.1 - 7.6e-22 77.1 9.3 1.2e-21 76.4 6.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.16 KOG96122.1 - 7.1e-16 58.1 0.1 1.3e-15 57.3 0.1 1.5 1 0 0 1 1 1 1 Smr domain DUF1031 PF06275.6 KOG96122.1 - 0.13 12.2 1.5 0.63 10.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1031) Ribosomal_L30 PF00327.15 KOG96123.1 - 1.2e-19 69.6 2.3 2.4e-19 68.6 1.6 1.6 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.7 KOG96123.1 - 2.9e-19 68.8 19.2 4.6e-19 68.2 13.3 1.3 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Tropomyosin PF00261.15 KOG96123.1 - 0.0013 17.8 5.6 0.0019 17.3 3.9 1.1 1 0 0 1 1 1 1 Tropomyosin DUF2514 PF10721.4 KOG96123.1 - 0.021 14.5 8.6 0.026 14.2 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) TLD PF07534.11 KOG96124.1 - 1.2e-27 96.6 0.1 3.4e-27 95.1 0.0 1.8 2 1 0 2 2 2 1 TLD Rad9 PF04139.8 KOG96125.1 - 1.2e-09 37.6 0.5 0.00019 20.6 0.1 2.2 2 0 0 2 2 2 2 Rad9 NUFIP1 PF10453.4 KOG96126.1 - 8e-17 60.4 5.1 1.6e-16 59.5 0.1 3.0 2 1 1 3 3 3 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) APC_CDC26 PF10471.4 KOG96126.1 - 0.042 14.5 0.8 0.042 14.5 0.6 3.5 3 1 0 3 3 3 0 Anaphase-promoting complex APC subunit 1 DUF544 PF04424.8 KOG96128.1 - 1.1e-33 115.6 0.2 1.9e-33 114.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF544) RRM_1 PF00076.17 KOG96129.1 - 1.2e-10 40.8 0.1 3.7e-10 39.3 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG96129.1 - 7.4e-08 32.2 0.0 1.8e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96129.1 - 0.0019 18.0 0.0 0.0038 17.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MBOAT PF03062.14 KOG96131.1 - 4.4e-67 226.4 27.6 4.4e-67 226.4 19.1 1.9 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Swi3 PF07962.7 KOG96131.1 - 0.056 13.0 0.6 1.3 8.7 0.0 2.4 1 1 1 2 2 2 0 Replication Fork Protection Component Swi3 NAD_kinase PF01513.16 KOG96132.1 - 1.1e-50 171.9 0.0 1.5e-50 171.5 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.19 KOG96132.1 - 0.074 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Glyco_hydro_10 PF00331.15 KOG96132.1 - 0.13 11.2 0.1 0.51 9.3 0.0 1.8 2 0 0 2 2 2 0 Glycosyl hydrolase family 10 MF_alpha_N PF05436.6 KOG96133.1 - 3.4e-39 132.4 1.4 4.5e-39 132.0 0.9 1.2 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus MF_alpha PF04648.7 KOG96133.1 - 2.1e-27 93.5 42.4 6.4e-07 29.1 2.4 4.2 4 0 0 4 4 4 4 Yeast mating factor alpha hormone DCR PF14047.1 KOG96133.1 - 0.011 15.9 2.8 30 4.9 0.0 4.0 1 1 3 4 4 4 0 Dppa2/4 conserved region CDC45 PF02724.9 KOG96134.1 - 9.2 4.1 25.9 1.7 6.5 2.7 2.0 2 0 0 2 2 2 0 CDC45-like protein RRM_6 PF14259.1 KOG96135.1 - 1e-23 83.0 1.6 1.8e-05 24.6 0.0 5.2 5 1 0 5 5 5 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOG96135.1 - 3.2e-23 81.1 1.1 5.3e-07 29.1 0.0 4.8 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96135.1 - 4.2e-20 71.3 4.0 1.8e-06 27.6 0.1 4.8 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KOG96135.1 - 0.0031 17.3 0.0 1.7 8.5 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.1 KOG96135.1 - 0.013 15.2 0.1 0.65 9.8 0.0 2.7 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Ribosomal_L36 PF00444.13 KOG96136.1 - 1.5e-20 72.8 8.6 2e-20 72.4 6.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L36 Crust_neurohorm PF01147.12 KOG96136.1 - 0.0079 15.4 0.9 0.011 15.0 0.6 1.2 1 0 0 1 1 1 1 Crustacean CHH/MIH/GIH neurohormone family WD40 PF00400.27 KOG96137.1 - 2e-20 71.8 21.0 2.4e-08 33.5 0.1 8.5 10 0 0 10 10 10 4 WD domain, G-beta repeat Nup160 PF11715.3 KOG96137.1 - 0.0075 14.4 4.1 2 6.4 0.0 3.5 3 1 0 3 3 3 2 Nucleoporin Nup120/160 PHD PF00628.24 KOG96138.1 - 6e-12 45.0 8.7 1.1e-11 44.2 6.0 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 KOG96138.1 - 0.57 9.5 6.0 1 8.7 4.1 1.4 1 0 0 1 1 1 0 PHD-finger TCO89 PF10452.4 KOG96139.1 - 5.1e-205 682.9 58.4 6.5e-205 682.6 40.5 1.1 1 0 0 1 1 1 1 TORC1 subunit TCO89 Metallophos PF00149.23 KOG96140.1 - 7.9e-41 139.6 0.1 1.2e-40 139.0 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RRM_6 PF14259.1 KOG96141.1 - 2.5e-13 49.7 0.0 3.8e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOG96141.1 - 4.8e-13 48.5 0.0 7.5e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96141.1 - 7.6e-11 41.7 0.0 1.2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Homeobox_KN PF05920.6 KOG96142.1 - 2.9e-18 65.2 1.0 6.1e-18 64.2 0.7 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.24 KOG96142.1 - 6.7e-06 25.6 0.7 1.8e-05 24.2 0.5 1.8 1 0 0 1 1 1 1 Homeobox domain TFR_dimer PF04253.10 KOG96143.1 - 2.8e-32 110.9 0.0 2.3e-31 107.9 0.0 2.2 2 0 0 2 2 2 1 Transferrin receptor-like dimerisation domain PA PF02225.17 KOG96143.1 - 6.9e-05 22.4 0.0 0.00051 19.6 0.0 2.2 2 0 0 2 2 2 1 PA domain PIGA PF08288.7 KOG96144.1 - 1.6e-44 150.1 1.8 3.6e-44 149.0 1.3 1.7 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.15 KOG96144.1 - 5e-28 97.6 0.0 8.4e-28 96.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 KOG96144.1 - 1e-19 70.9 0.6 1.7e-19 70.2 0.4 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 KOG96144.1 - 9.2e-13 48.6 0.0 1.3e-12 48.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 KOG96144.1 - 1.6e-12 47.7 0.0 4.3e-12 46.3 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.1 KOG96144.1 - 2.3e-05 24.2 1.0 5.7e-05 22.9 0.5 1.8 2 0 0 2 2 2 1 Glycosyl transferase 4-like Glyco_transf_5 PF08323.6 KOG96144.1 - 0.09 12.2 0.0 0.74 9.2 0.0 2.2 1 1 0 1 1 1 0 Starch synthase catalytic domain CAP_GLY PF01302.20 KOG96145.1 - 3.7e-18 64.9 0.2 6.3e-18 64.2 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain UbiA PF01040.13 KOG96146.1 - 3.8e-21 75.4 12.7 5.1e-21 75.0 8.8 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Oxidored_FMN PF00724.15 KOG96147.1 - 7.9e-126 419.6 0.0 9.1e-126 419.4 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF2414 PF10309.4 KOG96147.1 - 0.09 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2414) Cyt-b5 PF00173.23 KOG96148.1 - 1.7e-14 53.3 0.0 2.5e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TAP_C PF03943.8 KOG96149.1 - 7e-20 70.1 0.2 2.3e-19 68.5 0.0 2.0 2 0 0 2 2 2 1 TAP C-terminal domain LRR_4 PF12799.2 KOG96149.1 - 1.3e-06 27.8 11.3 1.1e-05 24.9 1.2 3.2 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 KOG96149.1 - 1.7e-05 24.4 0.5 2.9e-05 23.7 0.4 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.1 KOG96149.1 - 0.0052 16.7 3.4 0.88 9.8 0.1 3.8 3 0 0 3 3 3 1 Leucine Rich repeat NTF2 PF02136.15 KOG96149.1 - 0.012 15.9 1.3 0.25 11.7 0.4 2.8 2 1 0 2 2 2 0 Nuclear transport factor 2 (NTF2) domain LRR_1 PF00560.28 KOG96149.1 - 0.44 10.7 6.3 1.2e+02 3.3 0.0 4.9 4 0 0 4 4 4 0 Leucine Rich Repeat DNA_pol_B PF00136.16 KOG96151.1 - 1.5e-99 333.9 0.2 3.1e-99 332.8 0.2 1.5 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 KOG96151.1 - 6.6e-19 67.9 5.8 2.2e-11 43.2 0.8 3.1 3 0 0 3 3 3 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 KOG96151.1 - 2e-13 50.1 12.3 3.2e-13 49.4 7.6 2.1 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta SET PF00856.23 KOG96153.1 - 1.5e-10 41.5 0.2 8.2e-09 35.9 0.1 2.2 2 0 0 2 2 2 2 SET domain HATPase_c_3 PF13589.1 KOG96154.1 - 5e-14 52.1 0.1 9.8e-14 51.1 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOG96154.1 - 7.9e-08 32.0 0.0 2.6e-07 30.3 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.6 KOG96154.1 - 1.4e-05 24.7 0.0 0.00041 19.9 0.0 2.6 2 0 0 2 2 2 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.14 KOG96154.1 - 0.00072 19.0 0.1 0.0035 16.8 0.0 2.2 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain CCDC84 PF14968.1 KOG96155.1 - 3.7 6.9 6.1 6.9 6.0 4.2 1.4 1 0 0 1 1 1 0 Coiled coil protein 84 DUF3661 PF12400.3 KOG96156.1 - 1.4e-44 151.2 7.3 2.5e-44 150.4 5.1 1.4 1 0 0 1 1 1 1 Vaculolar membrane protein TMEM192 PF14802.1 KOG96156.1 - 0.019 13.7 0.1 0.042 12.7 0.1 1.6 1 0 0 1 1 1 0 TMEM192 family PARG_cat PF05028.9 KOG96157.1 - 0.081 12.1 2.7 0.041 13.1 0.3 1.7 2 0 0 2 2 2 0 Poly (ADP-ribose) glycohydrolase (PARG) tRNA-synt_1 PF00133.17 KOG96158.1 - 5.4e-42 143.6 0.0 1.1e-33 116.1 0.0 2.4 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 KOG96158.1 - 4.1e-20 71.7 0.5 2.3e-10 39.7 0.0 4.2 4 0 0 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.8 KOG96158.1 - 9e-13 48.2 0.0 2.8e-12 46.6 0.0 1.9 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 KOG96158.1 - 1.2e-06 27.9 0.0 2.3e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Pet20 PF08692.5 KOG96159.1 - 2.5e-35 121.3 3.6 4.8e-21 75.1 0.0 2.8 2 1 1 3 3 3 2 Mitochondrial protein Pet20 MRP-S33 PF08293.6 KOG96159.1 - 0.019 14.9 2.0 0.064 13.2 0.2 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal subunit S27 BCS1_N PF08740.6 KOG96159.1 - 0.025 14.1 0.7 0.037 13.6 0.5 1.3 1 0 0 1 1 1 0 BCS1 N terminal XLF PF09302.6 KOG96159.1 - 0.035 13.8 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 XLF (XRCC4-like factor) Methyltransf_15 PF09445.5 KOG96161.1 - 1e-62 210.5 0.0 1.6e-62 209.9 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 KOG96161.1 - 8.9e-10 38.6 0.0 1.3e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 KOG96161.1 - 2.6e-09 36.8 0.0 4.3e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_18 PF12847.2 KOG96161.1 - 4.6e-08 33.6 0.0 7.6e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOG96161.1 - 7.1e-08 32.1 0.0 1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOG96161.1 - 1.3e-05 25.4 0.0 2.3e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.13 KOG96161.1 - 0.0019 17.7 0.6 0.14 11.6 0.0 2.2 1 1 1 2 2 2 2 DNA methylase MTS PF05175.9 KOG96161.1 - 0.0033 16.8 0.0 0.0055 16.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.10 KOG96161.1 - 0.0039 16.5 0.0 0.006 15.9 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.7 KOG96161.1 - 0.0045 17.4 0.0 0.012 16.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MethyltransfD12 PF02086.10 KOG96161.1 - 0.0077 15.7 1.2 0.01 15.3 0.0 1.8 3 0 0 3 3 3 1 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_23 PF13489.1 KOG96161.1 - 0.0083 15.8 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOG96161.1 - 0.015 14.3 0.0 0.025 13.6 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Kinesin PF00225.18 KOG96163.1 - 3.9e-105 351.2 0.2 6e-105 350.6 0.2 1.3 1 0 0 1 1 1 1 Kinesin motor domain Fib_alpha PF08702.5 KOG96163.1 - 0.1 12.7 5.0 2.5 8.2 0.0 2.8 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family CCDC-167 PF15188.1 KOG96163.1 - 1.1 9.2 4.4 0.53 10.2 0.6 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 TMF_DNA_bd PF12329.3 KOG96163.1 - 7.7 6.4 13.5 11 5.9 0.0 4.7 5 0 0 5 5 5 0 TATA element modulatory factor 1 DNA binding RAP1 PF07218.6 KOG96163.1 - 8.6 4.3 11.7 14 3.6 8.1 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Asp PF00026.18 KOG96164.1 - 6.4e-105 350.8 0.0 7.7e-105 350.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOG96164.1 - 1.8e-10 41.0 0.0 3.3e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 KOG96164.1 - 6.4e-05 23.3 0.0 0.017 15.5 0.0 2.7 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.1 KOG96164.1 - 0.0042 16.6 0.0 0.02 14.4 0.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Pkinase PF00069.20 KOG96165.1 - 9.8e-79 264.1 0.0 2.2e-78 262.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96165.1 - 4.3e-38 130.8 0.0 8.6e-38 129.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 KOG96165.1 - 5.6e-28 96.8 1.2 8.5e-16 57.8 0.1 2.8 2 0 0 2 2 2 2 FHA domain Kinase-like PF14531.1 KOG96165.1 - 1.7e-06 27.1 0.0 3e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG96165.1 - 4.6e-05 22.5 0.0 9.5e-05 21.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG96165.1 - 0.00012 21.8 0.0 0.013 15.2 0.0 2.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 KOG96165.1 - 0.004 16.5 0.0 0.0078 15.5 0.0 1.4 1 0 0 1 1 1 1 RIO1 family PTPA PF03095.10 KOG96166.1 - 1.9e-116 388.4 1.7 2.1e-116 388.2 1.2 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein AsiA PF09010.5 KOG96166.1 - 0.054 13.3 0.1 0.2 11.5 0.0 2.0 2 0 0 2 2 2 0 Anti-Sigma Factor A WD40 PF00400.27 KOG96167.1 - 8.2e-48 158.6 14.1 2.4e-08 33.5 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 KOG96167.1 - 1.1e-05 23.7 3.7 0.084 10.9 0.0 3.7 1 1 2 3 3 3 3 Nucleoporin Nup120/160 PQQ_2 PF13360.1 KOG96167.1 - 0.00046 19.7 0.1 0.59 9.5 0.1 2.5 2 0 0 2 2 2 2 PQQ-like domain Nucleoporin_N PF08801.6 KOG96167.1 - 0.0056 15.4 0.3 3.8 6.1 0.1 4.0 1 1 3 4 4 4 1 Nup133 N terminal like Pkinase PF00069.20 KOG96168.1 - 1.8e-66 223.9 0.3 6.3e-66 222.1 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96168.1 - 1.6e-38 132.2 0.0 2.5e-38 131.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG96168.1 - 5.7e-08 32.0 0.0 9.5e-08 31.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG96168.1 - 0.03 13.3 0.1 0.26 10.3 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG96168.1 - 0.24 11.0 0.1 1.6 8.3 0.1 2.2 2 1 0 2 2 2 0 Phosphotransferase enzyme family APG5 PF04106.7 KOG96169.1 - 5.4e-37 127.1 0.0 6.8e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 ACPS PF01648.15 KOG96170.1 - 2.1e-19 69.4 0.0 3.3e-19 68.8 0.0 1.3 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily ABC_membrane_2 PF06472.10 KOG96171.1 - 5.6e-93 311.1 5.3 5.6e-93 311.1 3.7 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 KOG96171.1 - 2.2e-15 57.1 0.0 8.6e-15 55.2 0.0 2.0 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.14 KOG96171.1 - 0.00039 19.7 0.2 0.43 9.7 0.1 2.6 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 KOG96171.1 - 0.014 15.4 0.9 0.05 13.5 0.2 2.3 2 1 0 2 2 2 0 AAA ATPase domain ETRAMP PF09716.5 KOG96171.1 - 0.9 9.5 5.0 1.5 8.8 0.1 3.6 4 0 0 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) AAA_23 PF13476.1 KOG96171.1 - 5.2 7.3 14.0 1.9 8.8 5.1 3.2 2 1 0 2 2 2 0 AAA domain Nop53 PF07767.6 KOG96172.1 - 1.1e-82 278.1 45.7 1.3e-82 277.9 31.7 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) PspB PF06667.7 KOG96172.1 - 1.8 8.5 13.8 0.1 12.5 2.1 3.3 3 0 0 3 3 3 0 Phage shock protein B DivIC PF04977.10 KOG96172.1 - 8.3 5.9 10.7 0.31 10.5 2.3 2.5 3 0 0 3 3 3 0 Septum formation initiator Oxysterol_BP PF01237.13 KOG96173.1 - 2.3e-93 312.5 1.5 2.6e-93 312.3 1.1 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein chaperone_DMP PF10448.4 KOG96174.1 - 2.6e-27 95.4 0.0 3e-27 95.3 0.0 1.0 1 0 0 1 1 1 1 20S proteasome chaperone DUF2020 PF09449.5 KOG96174.1 - 0.14 11.7 0.0 0.63 9.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2020) Ribosomal_L35Ae PF01247.13 KOG96175.1 - 6.5e-42 141.2 0.9 7.3e-42 141.0 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.13 KOG96175.1 - 0.0077 16.1 0.0 3.5 7.6 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Pkinase PF00069.20 KOG96176.1 - 5.8e-64 215.7 0.0 1e-63 214.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96176.1 - 9.3e-38 129.7 0.0 1.6e-37 128.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG96176.1 - 4.2e-07 29.2 0.0 7.5e-07 28.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 KOG96176.1 - 0.0094 15.3 0.1 0.023 14.0 0.0 1.6 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 KOG96176.1 - 0.0095 15.6 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 KOG96176.1 - 0.026 13.6 0.1 0.078 12.0 0.1 1.8 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 KOG96177.1 - 8.4e-70 234.8 0.0 1.2e-69 234.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96177.1 - 1.1e-37 129.5 0.0 2.4e-37 128.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG96177.1 - 2.4e-08 33.3 0.0 4.7e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG96177.1 - 0.0047 16.0 0.0 0.0093 15.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG96177.1 - 0.039 13.6 0.0 0.24 11.0 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 KOG96177.1 - 0.067 12.0 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 WD40 PF00400.27 KOG96178.1 - 4.1e-08 32.8 3.8 0.0061 16.4 0.1 3.9 3 0 0 3 3 3 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 KOG96178.1 - 0.035 14.0 0.0 0.089 12.7 0.0 1.7 1 0 0 1 1 1 0 Histone-binding protein RBBP4 or subunit C of CAF1 complex PHD PF00628.24 KOG96179.1 - 1.3e-11 44.0 5.2 1.3e-11 44.0 3.6 2.1 2 0 0 2 2 2 1 PHD-finger LRR_4 PF12799.2 KOG96180.1 - 0.15 11.7 28.1 0.059 13.0 3.9 6.0 4 2 3 7 7 7 0 Leucine Rich repeats (2 copies) NifU_N PF01592.11 KOG96181.1 - 1.3e-54 183.5 0.0 1.6e-54 183.2 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain Mito_carr PF00153.22 KOG96182.1 - 2.2e-65 216.4 3.3 1.3e-26 92.1 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.14 KOG96182.1 - 0.045 13.7 1.9 0.074 13.1 0.1 2.4 2 2 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family Zn_clus PF00172.13 KOG96183.1 - 0.0016 18.2 11.9 0.005 16.7 8.2 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CtaG_Cox11 PF04442.9 KOG96184.1 - 1e-58 197.4 0.0 1.4e-58 196.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Ribosomal_L18p PF00861.17 KOG96185.1 - 1.5e-46 157.5 1.4 1.9e-46 157.1 0.0 1.8 2 0 0 2 2 2 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 KOG96185.1 - 4.2e-32 110.5 1.4 4.2e-32 110.5 1.0 1.8 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Thr_synth_N PF14821.1 KOG96185.1 - 0.027 14.4 0.1 1.5 8.9 0.0 2.6 2 0 0 2 2 2 0 Threonine synthase N terminus Imm24 PF15570.1 KOG96186.1 - 0.0081 15.8 3.7 0.015 15.0 2.5 1.5 1 1 0 1 1 1 1 Immunity protein 24 YEATS PF03366.11 KOG96187.1 - 1.1e-24 85.9 0.0 1.8e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 YEATS family TRF PF08558.5 KOG96188.1 - 8.9e-83 277.2 0.4 1.3e-82 276.7 0.3 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.26 KOG96188.1 - 4.8e-09 36.1 0.5 9.9e-09 35.1 0.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOG96188.1 - 0.00025 21.0 0.1 0.00073 19.5 0.1 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Linker_histone PF00538.14 KOG96189.1 - 2.9e-48 161.8 14.4 1.8e-24 85.6 0.2 3.1 3 0 0 3 3 3 2 linker histone H1 and H5 family Med3 PF11593.3 KOG96189.1 - 8.7 5.4 18.6 0.12 11.5 7.5 1.7 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal WD40 PF00400.27 KOG96190.1 - 1.2e-08 34.4 7.4 0.00011 21.8 0.1 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat IBN_N PF03810.14 KOG96191.1 - 2e-18 66.0 2.4 7.3e-18 64.2 0.3 3.1 3 0 0 3 3 3 1 Importin-beta N-terminal domain Fib_alpha PF08702.5 KOG96192.1 - 0.058 13.5 0.8 0.46 10.5 0.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Ribonuclease_T2 PF00445.13 KOG96193.1 - 1.7e-43 148.4 1.5 2.7e-43 147.8 1.1 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family Tfb2 PF03849.9 KOG96194.1 - 8.7e-157 521.4 1.3 8.7e-157 521.4 0.9 1.5 2 0 0 2 2 2 1 Transcription factor Tfb2 Helicase_C_3 PF13625.1 KOG96194.1 - 2.3e-05 24.1 0.0 7.3e-05 22.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Mei5 PF10376.4 KOG96195.1 - 7.4e-49 166.2 23.8 9.1e-49 165.9 16.5 1.1 1 0 0 1 1 1 1 Double-strand recombination repair protein tRNA-synt_His PF13393.1 KOG96195.1 - 0.47 9.4 6.9 1.6 7.6 0.3 2.1 2 0 0 2 2 2 0 Histidyl-tRNA synthetase DUF3479 PF11965.3 KOG96195.1 - 0.7 9.6 0.0 0.7 9.6 0.0 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF3479) APG6 PF04111.7 KOG96196.1 - 3.2e-99 331.9 18.9 3.2e-99 331.9 13.1 1.7 2 0 0 2 2 2 1 Autophagy protein Apg6 tRNA-synt_His PF13393.1 KOG96196.1 - 0.36 9.8 5.4 0.66 8.9 3.7 1.4 1 0 0 1 1 1 0 Histidyl-tRNA synthetase DEAD PF00270.24 KOG96197.1 - 2.1e-47 160.7 0.0 2.4e-45 154.0 0.0 2.1 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG96197.1 - 6e-27 93.3 0.1 1.1e-26 92.4 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOG96197.1 - 0.00048 20.0 0.0 0.0029 17.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit MethyTransf_Reg PF10119.4 KOG96197.1 - 0.014 15.8 0.1 0.039 14.4 0.0 1.7 1 0 0 1 1 1 0 Predicted methyltransferase regulatory domain CMS1 PF14617.1 KOG96197.1 - 0.043 12.8 0.0 0.084 11.9 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF1253 PF06862.7 KOG96197.1 - 0.054 11.9 0.0 0.28 9.5 0.0 2.0 2 1 0 3 3 3 0 Protein of unknown function (DUF1253) Mit_ribos_Mrp51 PF11709.3 KOG96198.1 - 9.1e-96 320.7 0.2 1.1e-95 320.5 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit Borrelia_lipo_1 PF05714.6 KOG96198.1 - 0.0069 15.4 2.0 0.023 13.7 1.4 1.8 2 0 0 2 2 2 1 Borrelia burgdorferi virulent strain associated lipoprotein NUDIX PF00293.23 KOG96199.1 - 1.6e-30 105.4 0.0 2.4e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Hist_deacetyl PF00850.14 KOG96200.1 - 4.3e-63 213.4 0.2 7.3e-63 212.7 0.1 1.3 1 0 0 1 1 1 1 Histone deacetylase domain RhoGAP PF00620.22 KOG96201.1 - 2.3e-37 127.9 2.4 7.6e-37 126.2 0.0 2.8 3 0 0 3 3 3 1 RhoGAP domain PX PF00787.19 KOG96201.1 - 1.8e-08 34.1 0.1 6.4e-08 32.3 0.1 2.0 1 0 0 1 1 1 1 PX domain PH PF00169.24 KOG96201.1 - 1.1e-05 25.5 0.0 1.1e-05 25.5 0.0 3.4 2 1 1 3 3 3 1 PH domain 2-Hacid_dh_C PF02826.14 KOG96202.1 - 2.5e-35 121.2 0.0 3.9e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 KOG96202.1 - 0.0016 17.9 0.0 0.0025 17.2 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ApbA PF02558.11 KOG96202.1 - 0.035 13.5 0.0 0.058 12.8 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.10 KOG96202.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase PEX11 PF05648.9 KOG96203.1 - 1.3e-08 34.4 5.0 2.5e-06 26.9 2.5 2.3 2 0 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Arginase PF00491.16 KOG96204.1 - 1.9e-73 247.1 0.0 2.2e-73 246.9 0.0 1.0 1 0 0 1 1 1 1 Arginase family GDPD PF03009.12 KOG96205.1 - 5.1e-92 307.9 0.0 1.3e-91 306.6 0.0 1.7 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family SPX PF03105.14 KOG96205.1 - 1.4e-29 103.7 14.5 1.4e-29 103.7 10.0 3.5 4 1 0 4 4 4 1 SPX domain Ank_2 PF12796.2 KOG96205.1 - 7.1e-25 87.1 0.2 7.4e-12 45.4 0.0 4.7 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOG96205.1 - 5.6e-19 66.9 1.5 0.0029 17.3 0.0 6.8 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.1 KOG96205.1 - 1.8e-16 60.1 8.9 1.7e-06 28.3 0.2 6.6 5 2 3 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOG96205.1 - 1.3e-10 40.4 11.7 0.38 11.1 0.0 6.9 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.1 KOG96205.1 - 1.8e-08 34.3 2.9 0.16 12.2 0.0 5.4 4 1 2 6 6 6 4 Ankyrin repeats (many copies) DUF3567 PF12091.3 KOG96206.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3567) Oxidored-like PF09791.4 KOG96207.1 - 1.1e-26 91.9 3.9 2.2e-26 91.0 2.7 1.5 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal ATPase-cat_bd PF12156.3 KOG96207.1 - 0.16 12.4 1.8 0.43 11.1 0.0 2.4 2 1 0 2 2 2 0 Putative metal-binding domain of cation transport ATPase HSP70 PF00012.15 KOG96208.1 - 3.1e-196 652.9 2.9 3.1e-196 652.9 2.0 1.9 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 KOG96208.1 - 1.2e-10 40.5 0.2 6.4e-10 38.1 0.0 1.9 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.1 KOG96208.1 - 9e-07 28.7 2.3 0.001 18.9 0.3 4.1 2 2 0 2 2 2 2 Cell division protein FtsA Trans_reg_C PF00486.23 KOG96208.1 - 0.067 13.1 0.1 0.3 11.0 0.0 2.1 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal Peptidase_M22 PF00814.20 KOG96208.1 - 0.13 11.7 0.7 17 4.8 0.1 3.2 1 1 2 3 3 3 0 Glycoprotease family AHS1 PF02682.11 KOG96208.1 - 0.16 11.4 0.6 0.39 10.1 0.0 2.0 2 0 0 2 2 2 0 Allophanate hydrolase subunit 1 PLRV_ORF5 PF01690.12 KOG96208.1 - 0.82 8.7 6.5 0.34 10.0 0.0 2.3 2 0 0 2 2 2 0 Potato leaf roll virus readthrough protein IncA PF04156.9 KOG96208.1 - 6.2 6.3 10.0 17 4.9 6.7 1.9 1 1 0 1 1 1 0 IncA protein GYF PF02213.11 KOG96209.1 - 2.1e-20 72.0 0.4 2.1e-20 72.0 0.3 2.0 2 0 0 2 2 2 1 GYF domain DUF4339 PF14237.1 KOG96209.1 - 0.0067 15.9 0.3 0.023 14.2 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4339) tRNA-synt_2 PF00152.15 KOG96210.1 - 7.9e-114 379.8 0.1 1e-113 379.5 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KOG96210.1 - 5.8e-06 26.0 0.1 1.2e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.20 KOG96210.1 - 5.8e-05 22.7 0.0 0.0024 17.4 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.15 KOG96210.1 - 0.03 13.5 0.6 0.72 8.9 0.1 2.8 2 1 1 3 3 3 0 tRNA synthetases class II core domain (F) Lactamase_B_2 PF12706.2 KOG96211.1 - 2e-33 115.5 0.0 3.1e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 KOG96211.1 - 2.8e-11 43.3 0.0 6.2e-11 42.2 0.0 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 KOG96211.1 - 0.038 13.6 0.0 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily PsbN PF02468.10 KOG96211.1 - 0.14 11.7 0.7 0.36 10.4 0.5 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) PAXNEB PF05625.6 KOG96212.1 - 6.2e-109 364.1 0.8 8e-109 363.8 0.6 1.0 1 0 0 1 1 1 1 PAXNEB protein WD40 PF00400.27 KOG96213.1 - 3.2e-07 29.9 0.4 0.00031 20.5 0.0 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat SieB PF14163.1 KOG96214.1 - 0.012 15.1 2.1 0.14 11.7 0.1 2.2 1 1 0 2 2 2 0 Superinfection exclusion protein B SPX PF03105.14 KOG96214.1 - 0.038 13.7 2.1 0.051 13.3 1.4 1.2 1 0 0 1 1 1 0 SPX domain DUF2681 PF10883.3 KOG96214.1 - 0.045 13.9 0.1 0.045 13.9 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) DUF607 PF04678.8 KOG96214.1 - 0.047 13.6 0.3 0.047 13.6 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF607 Lzipper-MIP1 PF14389.1 KOG96214.1 - 0.29 11.2 7.7 1.1 9.4 1.9 2.6 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Romo1 PF10247.4 KOG96215.1 - 6.4e-28 96.7 7.9 8.2e-28 96.4 5.5 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 tRNA-synt_1b PF00579.20 KOG96216.1 - 2.8e-82 276.1 0.0 4e-82 275.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Vma12 PF11712.3 KOG96217.1 - 0.14 11.8 1.2 0.16 11.6 0.8 1.1 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase PgaD PF13994.1 KOG96217.1 - 0.21 11.0 3.1 0.24 10.8 2.1 1.3 1 1 0 1 1 1 0 PgaD-like protein Rad4 PF03835.10 KOG96218.1 - 6.3e-12 45.1 0.8 1.7e-11 43.6 0.6 1.7 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.14 KOG96218.1 - 2.6e-09 37.2 0.2 5.7e-09 36.1 0.0 1.7 2 0 0 2 2 2 1 Transglutaminase-like superfamily Zn_Tnp_IS1595 PF12760.2 KOG96218.1 - 0.55 10.0 9.1 2.9 7.7 6.3 2.2 1 1 0 1 1 1 0 Transposase zinc-ribbon domain Abhydrolase_1 PF00561.15 KOG96219.1 - 1.9e-26 93.0 0.0 2.8e-26 92.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOG96219.1 - 1.5e-14 54.4 0.0 2.7e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOG96219.1 - 8.8e-08 32.0 0.0 3.6e-07 30.0 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOG96219.1 - 0.017 14.3 0.0 0.93 8.6 0.0 2.4 2 0 0 2 2 2 0 Prolyl oligopeptidase family Sec62 PF03839.11 KOG96220.1 - 3.5e-77 258.8 1.4 4.4e-77 258.4 1.0 1.1 1 0 0 1 1 1 1 Translocation protein Sec62 Fip1 PF05182.8 KOG96220.1 - 0.18 11.0 5.7 0.82 8.9 0.3 2.6 3 0 0 3 3 3 0 Fip1 motif NOGCT PF08155.6 KOG96221.1 - 1.4e-27 95.1 1.5 3.7e-27 93.7 1.1 1.8 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.9 KOG96221.1 - 1.9e-27 94.8 0.4 4.7e-27 93.6 0.3 1.7 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.18 KOG96221.1 - 1.1e-15 57.6 0.0 2.8e-15 56.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOG96221.1 - 1.7e-07 30.6 0.0 3.7e-07 29.5 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.7 KOG96221.1 - 0.0003 20.0 0.1 0.00068 18.8 0.1 1.7 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 KOG96221.1 - 0.0048 17.3 0.1 0.018 15.5 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein Dynamin_N PF00350.18 KOG96221.1 - 0.019 14.8 0.2 10 5.8 0.0 3.1 2 1 1 3 3 3 0 Dynamin family SLAC1 PF03595.12 KOG96222.1 - 4.7e-85 285.1 33.8 5.4e-85 284.9 23.4 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel UL2 PF08196.6 KOG96222.1 - 9.5 6.0 10.8 4.1 7.2 1.5 3.4 3 0 0 3 3 3 0 UL2 protein Pyr_redox_2 PF07992.9 KOG96223.1 - 1.7e-40 139.0 0.6 2.9e-40 138.3 0.5 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 KOG96223.1 - 1.8e-36 124.5 1.0 1.5e-35 121.5 0.1 2.4 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 KOG96223.1 - 3.1e-20 72.3 5.4 7.1e-19 67.9 0.8 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOG96223.1 - 1.8e-08 34.7 0.1 1.6e-07 31.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOG96223.1 - 2.3e-08 32.9 5.4 0.027 12.9 0.2 3.8 2 1 2 4 4 4 3 HI0933-like protein FAD_oxidored PF12831.2 KOG96223.1 - 5.9e-08 32.2 0.1 4.4e-07 29.3 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.1 KOG96223.1 - 3.5e-06 26.1 0.0 6.2e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.16 KOG96223.1 - 7.2e-06 25.6 1.4 0.00094 18.7 0.0 2.6 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.17 KOG96223.1 - 0.0001 21.2 0.5 0.0001 21.2 0.4 2.9 2 1 1 3 3 3 1 Glucose inhibited division protein A 3HCDH_N PF02737.13 KOG96223.1 - 0.00033 20.3 2.5 0.0019 17.8 0.1 2.5 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.19 KOG96223.1 - 0.00052 19.0 0.6 0.00052 19.0 0.4 2.9 2 1 1 3 3 3 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.14 KOG96223.1 - 0.00059 19.0 0.7 0.75 8.9 0.0 3.1 3 0 0 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 KOG96223.1 - 0.0018 18.5 0.5 0.78 10.0 0.0 2.9 3 1 0 3 3 3 1 Putative NAD(P)-binding Thi4 PF01946.12 KOG96223.1 - 0.0065 15.5 1.0 0.025 13.6 0.1 2.2 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.14 KOG96223.1 - 0.0069 15.4 0.9 1.8 7.5 0.1 2.4 2 0 0 2 2 2 2 FAD binding domain DUF1837 PF08878.6 KOG96223.1 - 0.013 15.0 1.3 0.1 12.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1837) NAD_Gly3P_dh_N PF01210.18 KOG96223.1 - 0.042 13.5 0.8 0.56 9.9 0.0 2.4 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.9 KOG96223.1 - 0.048 13.0 0.1 0.11 11.9 0.1 1.7 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain CPSase_L_chain PF00289.17 KOG96223.1 - 0.077 13.0 0.1 2.6 8.1 0.0 2.9 3 0 0 3 3 2 0 Carbamoyl-phosphate synthase L chain, N-terminal domain FAD_binding_2 PF00890.19 KOG96223.1 - 2.7 6.7 11.8 0.024 13.4 1.1 2.6 4 0 0 4 4 4 0 FAD binding domain NAD_binding_8 PF13450.1 KOG96223.1 - 7.9 6.5 9.4 0.12 12.4 1.0 2.1 2 0 0 2 2 1 0 NAD(P)-binding Rossmann-like domain Ribosomal_S6e PF01092.14 KOG96224.1 - 3.1e-25 88.2 0.2 6.4e-25 87.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e Cadherin_C PF01049.12 KOG96224.1 - 0.054 13.5 0.2 0.081 12.9 0.1 1.2 1 0 0 1 1 1 0 Cadherin cytoplasmic region SRF-TF PF00319.13 KOG96225.1 - 8.3e-25 85.7 0.1 1.6e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Aldo_ket_red PF00248.16 KOG96226.1 - 8e-63 211.8 0.1 9e-63 211.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Glyco_hydro_97 PF10566.4 KOG96226.1 - 0.0093 15.0 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 Glycoside hydrolase 97 Ceramidase PF05875.7 KOG96227.1 - 6.1e-99 330.4 18.8 7.1e-99 330.2 13.0 1.0 1 0 0 1 1 1 1 Ceramidase DUF4231 PF14015.1 KOG96227.1 - 0.00063 19.7 1.4 0.00098 19.0 0.0 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF4231) Radical_SAM PF04055.16 KOG96228.1 - 6.1e-16 59.0 0.4 1.7e-15 57.5 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 KOG96228.1 - 1.4e-11 44.2 0.0 4.5e-11 42.6 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Sec16_C PF12931.2 KOG96229.1 - 2.3e-85 286.7 0.0 4.4e-85 285.8 0.0 1.5 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.2 KOG96229.1 - 7.4e-19 67.8 0.3 3.8e-18 65.5 0.2 2.4 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Sec16_N PF12935.2 KOG96229.1 - 2.4e-10 40.7 35.5 2.4e-10 40.7 24.6 5.7 5 1 2 7 7 7 1 Vesicle coat trafficking protein Sec16 N-terminus BRO1 PF03097.13 KOG96230.1 - 3.3e-97 325.5 5.4 6.4e-97 324.6 3.7 1.5 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 KOG96230.1 - 3.3e-42 144.4 14.1 5.4e-42 143.7 8.6 2.3 2 1 0 2 2 2 1 ALIX V-shaped domain binding to HIV tRNA_int_end_N2 PF12928.2 KOG96231.1 - 1.4e-20 72.4 0.0 2.8e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term DUF3535 PF12054.3 KOG96232.1 - 4.3e-154 513.3 0.7 1.2e-153 511.8 0.5 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3535) SNF2_N PF00176.18 KOG96232.1 - 1e-77 260.9 0.0 1.9e-77 260.0 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOG96232.1 - 9.7e-14 51.0 0.0 2.7e-13 49.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.17 KOG96232.1 - 3.8e-13 48.2 5.4 0.052 13.6 0.0 8.4 8 0 0 8 8 8 3 HEAT repeat Vac14_Fab1_bd PF12755.2 KOG96232.1 - 3.5e-07 30.4 0.1 1.5 9.2 0.0 5.9 7 0 0 7 7 7 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 KOG96232.1 - 9.4e-06 25.9 3.3 26 5.4 0.0 7.7 7 0 0 7 7 7 0 HEAT-like repeat Ribosomal_L21e PF01157.13 KOG96234.1 - 3.2e-40 135.9 4.9 4.2e-40 135.5 2.9 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.4 KOG96234.1 - 0.02 14.2 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Mt_ATP-synt_B PF05405.9 KOG96235.1 - 8.8e-58 194.3 6.0 1.1e-57 194.0 4.2 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) SRX PF09201.5 KOG96235.1 - 0.01 15.5 0.5 0.015 15.0 0.3 1.3 1 0 0 1 1 1 0 SRX Plug PF07715.10 KOG96236.1 - 0.095 13.0 1.8 0.12 12.7 0.3 1.9 2 0 0 2 2 2 0 TonB-dependent Receptor Plug Domain GPI2 PF06432.6 KOG96237.1 - 4.3e-58 196.8 25.9 5.7e-58 196.4 17.9 1.2 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase GCR1_C PF12550.3 KOG96238.1 - 3.8e-21 74.7 3.0 4.7e-21 74.4 1.1 2.1 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes AAA PF00004.24 KOG96239.1 - 1.9e-41 141.3 0.0 6e-41 139.7 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOG96239.1 - 3e-05 23.2 0.0 6.3e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOG96239.1 - 6.2e-05 23.1 1.1 0.0026 17.8 0.3 2.9 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.9 KOG96239.1 - 0.00013 21.9 0.6 0.00031 20.7 0.0 2.0 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 KOG96239.1 - 0.0006 19.5 0.0 0.0038 16.9 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 KOG96239.1 - 0.00064 18.5 0.0 0.00064 18.5 0.0 2.0 2 0 0 2 2 2 1 TIP49 C-terminus AAA_14 PF13173.1 KOG96239.1 - 0.0013 18.5 0.0 0.0048 16.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain Vps4_C PF09336.5 KOG96239.1 - 0.0015 18.3 0.0 0.0044 16.8 0.0 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.12 KOG96239.1 - 0.0024 17.2 0.3 0.0084 15.5 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 KOG96239.1 - 0.0026 16.9 0.0 0.0074 15.4 0.0 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 KOG96239.1 - 0.0039 17.4 5.5 0.012 15.9 0.0 3.2 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOG96239.1 - 0.0045 17.0 0.1 0.36 10.7 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_17 PF13207.1 KOG96239.1 - 0.0047 17.7 7.8 0.016 15.9 0.0 3.5 4 1 0 4 4 3 1 AAA domain AAA_25 PF13481.1 KOG96239.1 - 0.0071 15.7 0.3 0.27 10.6 0.1 2.5 1 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOG96239.1 - 0.0085 15.8 0.0 0.028 14.1 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_33 PF13671.1 KOG96239.1 - 0.032 14.0 0.7 0.084 12.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 KOG96239.1 - 0.36 10.3 6.8 0.081 12.5 0.1 2.9 3 1 0 3 3 3 0 AAA domain UCH PF00443.24 KOG96240.1 - 3.2e-48 164.2 8.7 4.7e-48 163.6 6.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOG96240.1 - 6.6e-10 38.8 9.4 3e-09 36.7 4.8 2.2 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase KH_5 PF13184.1 KOG96241.1 - 0.079 12.7 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 NusA-like KH domain VPS9 PF02204.13 KOG96242.1 - 3.8e-17 62.2 1.5 1e-16 60.8 1.1 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF1390 PF07150.6 KOG96242.1 - 0.72 9.1 7.1 0.078 12.3 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1390) polyprenyl_synt PF00348.12 KOG96243.1 - 4.3e-45 153.6 0.0 5.3e-45 153.2 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase DUF3605 PF12239.3 KOG96245.1 - 1.6e-46 158.0 0.0 1.9e-46 157.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Arrestin_C PF02752.17 KOG96246.1 - 0.0014 18.7 3.7 0.0014 18.7 2.6 2.9 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain VPS28 PF03997.7 KOG96247.1 - 2.1e-78 262.2 5.0 2.5e-78 262.0 3.5 1.0 1 0 0 1 1 1 1 VPS28 protein DUF3114 PF11311.3 KOG96247.1 - 0.00057 19.3 0.5 0.0086 15.4 0.1 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF3114) Speriolin_C PF15059.1 KOG96247.1 - 0.013 15.5 0.0 0.027 14.4 0.0 1.6 1 0 0 1 1 1 0 Speriolin C-terminus DUF3417 PF11897.3 KOG96247.1 - 0.014 15.3 0.5 0.024 14.6 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3417) Bac_surface_Ag PF01103.18 KOG96247.1 - 0.03 13.7 1.4 0.037 13.4 0.9 1.1 1 0 0 1 1 1 0 Surface antigen MipZ PF09140.6 KOG96247.1 - 0.066 12.2 0.0 0.13 11.3 0.0 1.5 1 0 0 1 1 1 0 ATPase MipZ DUF1759 PF03564.10 KOG96247.1 - 0.085 12.6 0.3 0.085 12.6 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1759) DUF1454 PF07305.7 KOG96247.1 - 0.12 11.4 1.6 0.71 8.9 0.2 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1454) Pro_isomerase PF00160.16 KOG96248.1 - 2.3e-11 44.1 0.0 4.2e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD NIF PF03031.13 KOG96249.1 - 1.2e-42 145.2 0.1 2e-42 144.5 0.1 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase NeA_P2 PF12312.3 KOG96249.1 - 0.12 11.5 0.5 0.21 10.8 0.3 1.3 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein Aldedh PF00171.17 KOG96250.1 - 4.1e-172 572.6 0.0 4.6e-172 572.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family FliD_C PF07195.7 KOG96250.1 - 0.021 14.1 0.1 0.042 13.1 0.0 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus CorA PF01544.13 KOG96251.1 - 0.0099 14.9 13.4 0.027 13.5 9.2 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Glutaredoxin PF00462.19 KOG96252.1 - 1.1e-16 60.5 0.0 1.7e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin ABC2_membrane PF01061.19 KOG96253.1 - 6.8e-71 237.7 46.6 1.5e-36 125.5 8.6 2.8 3 0 0 3 3 2 2 ABC-2 type transporter PDR_CDR PF06422.7 KOG96253.1 - 7.4e-36 121.9 1.6 8.3e-29 99.2 0.0 2.8 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.22 KOG96253.1 - 2.5e-35 121.7 0.0 8.8e-17 61.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.1 KOG96253.1 - 1.6e-11 44.0 0.1 4.2e-11 42.7 0.1 1.8 1 1 0 1 1 1 1 ABC-transporter extracellular N-terminal DUF258 PF03193.11 KOG96253.1 - 2.8e-06 26.6 0.0 0.00023 20.3 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ABC2_membrane_3 PF12698.2 KOG96253.1 - 8.8e-06 24.9 26.4 0.00027 20.0 5.5 2.9 2 1 0 2 2 2 2 ABC-2 family transporter protein SMC_N PF02463.14 KOG96253.1 - 3.2e-05 23.2 0.0 0.17 11.0 0.0 3.1 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 KOG96253.1 - 4.2e-05 23.0 0.0 0.018 14.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 KOG96253.1 - 0.00027 20.4 0.1 0.0011 18.3 0.1 1.9 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 KOG96253.1 - 0.0003 20.2 0.2 0.015 14.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_17 PF13207.1 KOG96253.1 - 0.00067 20.4 0.1 0.013 16.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOG96253.1 - 0.00071 19.7 0.0 0.036 14.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOG96253.1 - 0.0008 19.4 0.3 0.0075 16.2 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain UPF0079 PF02367.12 KOG96253.1 - 0.0014 18.2 0.6 0.016 14.8 0.1 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_18 PF13238.1 KOG96253.1 - 0.0016 18.7 0.1 0.11 12.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain NACHT PF05729.7 KOG96253.1 - 0.0051 16.4 0.0 0.06 12.9 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA_21 PF13304.1 KOG96253.1 - 0.0055 16.7 0.0 0.078 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 KOG96253.1 - 0.007 16.3 0.0 1.6 8.7 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_19 PF13245.1 KOG96253.1 - 0.021 14.5 0.1 0.18 11.5 0.0 2.4 2 0 0 2 2 2 0 Part of AAA domain Zeta_toxin PF06414.7 KOG96253.1 - 0.029 13.4 0.0 0.79 8.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin RNA_helicase PF00910.17 KOG96253.1 - 0.035 14.2 0.7 1.7 8.8 0.0 3.1 3 0 0 3 3 3 0 RNA helicase Miro PF08477.8 KOG96253.1 - 0.056 13.9 0.0 18 5.8 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein AAA_33 PF13671.1 KOG96253.1 - 0.057 13.2 0.1 1.4 8.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 KOG96253.1 - 0.077 12.7 0.1 14 5.3 0.0 3.3 3 0 0 3 3 3 0 NTPase SbcCD_C PF13558.1 KOG96253.1 - 0.078 12.9 0.1 3.3 7.7 0.0 3.1 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.1 KOG96253.1 - 0.19 11.3 0.2 2.4 7.6 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 KOG96253.1 - 0.23 10.8 1.5 4.8 6.5 0.3 2.7 3 0 0 3 3 3 0 AAA-like domain Retinin_C PF04527.7 KOG96253.1 - 0.33 10.9 1.1 0.42 10.6 0.0 1.7 2 0 0 2 2 1 0 Drosophila Retinin like protein Gly_transf_sug PF04488.10 KOG96254.1 - 5.7e-23 81.2 0.0 1.3e-22 80.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 KOG96254.1 - 0.0012 17.3 3.6 0.1 11.0 0.4 2.4 2 0 0 2 2 2 2 TcdA/TcdB catalytic glycosyltransferase domain Lge1 PF11488.3 KOG96255.1 - 1.1e-16 60.7 1.0 2.2e-16 59.7 0.7 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein LGE1 DUF605 PF04652.11 KOG96255.1 - 1.2 8.4 16.8 1.7 7.9 11.7 1.3 1 0 0 1 1 1 0 Vta1 like zf-CCCH PF00642.19 KOG96256.1 - 5.2e-11 41.9 11.3 6.5e-06 25.6 2.1 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 KOG96256.1 - 0.0032 17.4 18.3 0.3 11.1 3.2 3.0 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type LRV_FeS PF05484.6 KOG96256.1 - 0.12 11.9 0.6 6.7 6.3 0.1 2.4 2 0 0 2 2 2 0 LRV protein FeS4 cluster Glyco_transf_15 PF01793.11 KOG96257.1 - 2.1e-100 335.8 9.8 2.7e-100 335.5 6.8 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Arf PF00025.16 KOG96258.1 - 3.6e-48 163.0 0.3 4.5e-48 162.7 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KOG96258.1 - 1.5e-15 56.9 0.0 1.8e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG96258.1 - 6.6e-13 49.1 0.0 1e-12 48.5 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 KOG96258.1 - 1.1e-12 47.5 0.1 1.5e-12 47.1 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 KOG96258.1 - 1.9e-10 40.0 1.8 6.5e-06 25.0 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.22 KOG96258.1 - 3.7e-09 36.2 0.0 2.2e-08 33.7 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KOG96258.1 - 3e-08 33.0 0.1 3.7e-08 32.7 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KOG96258.1 - 2.1e-06 27.6 0.0 4.6e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 KOG96258.1 - 0.015 15.4 0.1 0.057 13.5 0.0 2.0 1 1 1 2 2 2 0 AAA domain Thymidylate_kin PF02223.12 KOG96258.1 - 0.056 12.8 0.2 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 Thymidylate kinase AAA_14 PF13173.1 KOG96258.1 - 0.065 13.1 0.2 0.15 11.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain Anp1 PF03452.9 KOG96259.1 - 2.3e-109 364.7 0.1 2.8e-109 364.4 0.1 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.21 KOG96259.1 - 0.016 14.9 0.0 0.031 13.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 EF1G PF00647.14 KOG96261.1 - 2.2e-44 149.5 0.3 4.6e-44 148.5 0.0 1.7 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.15 KOG96261.1 - 1.5e-11 44.2 0.0 7.7e-11 42.0 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 KOG96261.1 - 4.1e-11 42.7 0.0 8.1e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 KOG96261.1 - 2.3e-07 30.6 0.1 6.2e-07 29.2 0.1 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOG96261.1 - 0.00089 19.6 0.1 0.0018 18.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 KOG96261.1 - 0.0088 16.2 0.0 0.028 14.6 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Mito_fiss_reg PF05308.6 KOG96261.1 - 0.32 10.3 1.3 0.54 9.5 0.9 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator DEC-1_N PF04625.8 KOG96261.1 - 8.2 4.9 8.1 17 3.9 5.6 1.4 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Sgf11 PF08209.6 KOG96262.1 - 8.1e-16 57.0 3.8 1.1e-15 56.6 2.7 1.2 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) zf-C2HC_2 PF13913.1 KOG96262.1 - 0.00056 19.5 0.2 0.00076 19.0 0.2 1.2 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-CpG_bind_C PF12269.3 KOG96262.1 - 0.091 12.2 0.4 0.12 11.7 0.2 1.3 1 1 0 1 1 1 0 CpG binding protein zinc finger C terminal domain Skp1_POZ PF03931.10 KOG96263.1 - 2.9e-19 68.8 0.3 5.3e-19 68.0 0.0 1.5 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.26 KOG96263.1 - 0.0022 17.9 0.2 0.0072 16.2 0.1 1.7 1 1 0 1 1 1 1 BTB/POZ domain Vps16_N PF04841.8 KOG96264.1 - 2.2e-123 411.8 0.2 3.4e-123 411.2 0.2 1.3 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.7 KOG96264.1 - 1.3e-110 369.3 9.3 1.8e-110 368.8 6.5 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region RRM_1 PF00076.17 KOG96265.1 - 6.4e-56 185.8 1.0 1.9e-19 69.0 0.2 5.4 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG96265.1 - 5.4e-45 151.2 0.5 2.2e-13 49.9 0.1 5.1 5 0 0 5 5 5 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96265.1 - 3.6e-17 61.9 1.2 1.4e-06 28.0 0.0 4.5 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HIF-1a_CTAD PF08778.5 KOG96265.1 - 0.083 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 HIF-1 alpha C terminal transactivation domain Pkinase PF00069.20 KOG96266.1 - 2.4e-52 177.6 0.5 3e-50 170.8 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96266.1 - 1.9e-23 82.8 0.1 1.4e-22 80.0 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase FLILHELTA PF10306.4 KOG96267.1 - 7.9e-27 93.1 0.1 1.3e-26 92.3 0.1 1.4 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA tRNA-synt_1 PF00133.17 KOG96268.1 - 2.2e-153 511.4 0.1 3.1e-153 510.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 KOG96268.1 - 2.5e-22 79.1 3.6 3.2e-12 45.8 0.1 4.3 4 1 0 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.8 KOG96268.1 - 4.2e-21 75.3 0.7 9.9e-21 74.0 0.5 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA zf-FPG_IleRS PF06827.9 KOG96268.1 - 0.0034 16.9 2.4 0.0084 15.7 1.6 1.7 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS DZR PF12773.2 KOG96268.1 - 0.025 14.3 0.4 0.051 13.4 0.3 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-C2H2 PF00096.21 KOG96270.1 - 6.5e-10 38.7 10.1 6.9e-05 22.9 1.4 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG96270.1 - 1.1e-08 34.7 5.1 0.00094 19.3 0.8 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KOG96270.1 - 4.5e-05 23.5 4.4 0.00043 20.4 0.1 2.8 3 0 0 3 3 3 1 Zinc-finger double domain C1_4 PF07975.7 KOG96270.1 - 6.7e-05 22.8 2.9 0.025 14.5 0.1 2.2 2 0 0 2 2 2 2 TFIIH C1-like domain zf-C2H2_jaz PF12171.3 KOG96270.1 - 0.042 13.9 2.6 2.1 8.5 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.1 KOG96270.1 - 0.054 13.7 1.2 0.054 13.7 0.9 2.6 2 1 0 2 2 2 0 C2H2-type zinc-finger domain Zn_ribbon_recom PF13408.1 KOG96270.1 - 0.059 13.6 2.9 0.13 12.5 0.7 2.1 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-C2H2_6 PF13912.1 KOG96270.1 - 0.094 12.6 8.2 1.2 9.1 0.6 2.5 2 1 0 2 2 2 0 C2H2-type zinc finger Baculo_ME53 PF06061.6 KOG96270.1 - 0.2 10.6 4.3 0.42 9.5 0.2 2.6 1 1 2 3 3 3 0 Baculoviridae ME53 C1_1 PF00130.17 KOG96270.1 - 0.39 10.4 4.3 5.7 6.7 0.1 2.4 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RIG-I_C-RD PF11648.3 KOG96270.1 - 0.51 10.2 5.4 1.1 9.1 1.0 2.6 1 1 1 2 2 2 0 C-terminal domain of RIG-I zf-C2H2_3 PF13878.1 KOG96270.1 - 0.76 9.3 4.0 0.68 9.5 0.2 2.3 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO LIM PF00412.17 KOG96270.1 - 2 8.5 4.9 9.6 6.3 0.6 2.3 1 1 1 2 2 2 0 LIM domain zf-C2HC_2 PF13913.1 KOG96270.1 - 2.5 7.8 7.8 2.5 7.8 2.2 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type NAC PF01849.13 KOG96271.1 - 5.2e-17 61.1 0.1 1e-16 60.1 0.1 1.5 1 0 0 1 1 1 1 NAC domain Ribosomal_60s PF00428.14 KOG96271.1 - 0.0042 17.4 2.4 0.048 14.0 0.1 2.1 2 0 0 2 2 2 1 60s Acidic ribosomal protein Glyco_hydro_20b PF02838.10 KOG96271.1 - 0.015 15.8 0.5 0.039 14.4 0.1 1.7 2 0 0 2 2 2 0 Glycosyl hydrolase family 20, domain 2 E1-E2_ATPase PF00122.15 KOG96272.1 - 1.2e-61 207.6 6.1 2.6e-61 206.6 4.2 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 KOG96272.1 - 1e-23 84.9 0.0 2e-23 83.9 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOG96272.1 - 4.4e-15 56.3 0.0 9.1e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 KOG96272.1 - 2.5e-10 39.6 0.9 4.3e-10 38.9 0.0 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 KOG96272.1 - 0.0012 18.4 0.3 0.0029 17.2 0.1 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOG96272.1 - 0.016 15.1 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit SR-25 PF10500.4 KOG96272.1 - 0.18 11.2 8.3 0.29 10.5 5.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MUG113 PF13455.1 KOG96273.1 - 2.8e-08 34.0 0.2 1.4e-06 28.6 0.1 2.4 1 1 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.4 KOG96273.1 - 3.6e-08 33.7 0.1 0.0011 19.2 0.1 2.2 1 1 1 2 2 2 2 T5orf172 domain DUF3216 PF11505.3 KOG96274.1 - 0.033 13.9 0.1 0.22 11.3 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3216) ApbA_C PF08546.6 KOG96275.1 - 1.2e-06 28.4 0.3 6.6e-06 26.1 0.0 2.3 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal Pkinase PF00069.20 KOG96276.1 - 1e-62 211.6 0.0 1.2e-62 211.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96276.1 - 6.5e-28 97.5 0.0 8.8e-28 97.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG96276.1 - 0.0005 19.1 0.0 0.00061 18.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 KOG96276.1 - 0.045 12.5 0.0 0.068 11.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DUF1573 PF07610.6 KOG96276.1 - 0.057 13.0 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1573) APH PF01636.18 KOG96276.1 - 0.06 13.0 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family AdoMet_MTase PF07757.8 KOG96277.1 - 5.5e-42 142.4 0.1 9.9e-42 141.5 0.1 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_31 PF13847.1 KOG96277.1 - 0.0019 17.7 0.0 0.004 16.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOG96277.1 - 0.12 12.9 0.0 0.35 11.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain SUV3_C PF12513.3 KOG96278.1 - 6.9e-18 63.8 1.9 2.1e-17 62.2 1.3 1.9 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.26 KOG96278.1 - 3.3e-13 49.2 0.0 6.3e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Thiolase_N PF00108.18 KOG96279.1 - 1.2e-101 339.0 2.4 1.6e-101 338.7 1.7 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 KOG96279.1 - 1.7e-45 153.4 0.8 3.7e-45 152.3 0.1 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 KOG96279.1 - 4.9e-06 26.1 1.9 4.9e-06 26.1 1.3 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Pkinase PF00069.20 KOG96281.1 - 1.5e-48 165.1 1.9 9.1e-47 159.3 1.3 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96281.1 - 2.8e-20 72.4 0.4 8e-19 67.7 0.1 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG96281.1 - 1.8e-05 23.8 0.0 4.5e-05 22.5 0.0 1.8 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 KOG96281.1 - 0.019 14.6 0.1 0.037 13.7 0.1 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Phytochelatin_C PF09328.5 KOG96281.1 - 0.019 14.4 0.0 0.043 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1984) Spo7_2_N PF15407.1 KOG96282.1 - 0.038 13.4 0.0 0.11 12.0 0.0 1.7 1 0 0 1 1 1 0 Sporulation protein family 7 Striatin PF08232.7 KOG96282.1 - 0.35 11.1 3.7 0.25 11.6 0.9 1.8 2 0 0 2 2 2 0 Striatin family MTHFR PF02219.12 KOG96283.1 - 7.5e-114 379.6 0.0 1e-113 379.2 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase ERCC4 PF02732.10 KOG96284.1 - 6.1e-24 84.4 0.2 2.8e-23 82.2 0.0 2.3 2 0 0 2 2 2 1 ERCC4 domain GATA PF00320.22 KOG96285.1 - 6e-15 54.2 3.2 1.4e-14 53.1 2.2 1.7 1 0 0 1 1 1 1 GATA zinc finger zf-C2H2_3 PF13878.1 KOG96285.1 - 0.26 10.8 1.7 12 5.5 0.1 2.6 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO DUF4379 PF14311.1 KOG96285.1 - 0.39 10.5 4.5 1.5 8.6 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4379) DZR PF12773.2 KOG96285.1 - 0.94 9.3 4.2 19 5.2 2.9 2.3 1 1 0 1 1 1 0 Double zinc ribbon Peptidase_C48 PF02902.14 KOG96286.1 - 9.4e-43 146.3 0.4 9.4e-43 146.3 0.3 2.3 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain V_ATPase_I PF01496.14 KOG96286.1 - 1.8 6.3 10.6 2.6 5.7 7.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family VTC PF09359.5 KOG96287.1 - 5.1e-100 334.1 4.7 5.1e-100 334.1 3.3 1.9 2 0 0 2 2 2 1 VTC domain SPX PF03105.14 KOG96287.1 - 2.6e-19 70.0 13.8 4e-13 49.7 2.9 5.0 2 2 1 3 3 3 2 SPX domain DUF202 PF02656.10 KOG96287.1 - 8.4e-09 35.5 2.1 8.4e-09 35.5 1.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Apc4 PF12896.2 KOG96287.1 - 0.0079 15.5 0.3 2.8 7.1 0.0 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 4 MBOAT PF03062.14 KOG96287.1 - 0.057 12.5 0.0 0.091 11.8 0.0 1.2 1 0 0 1 1 1 0 MBOAT, membrane-bound O-acyltransferase family Pyr_redox_dim PF02852.17 KOG96289.1 - 9.5e-28 96.4 0.0 6e-26 90.6 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 KOG96289.1 - 3.7e-21 75.9 0.0 4e-20 72.5 0.0 2.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOG96289.1 - 1.5e-17 63.7 0.5 1.5e-16 60.5 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOG96289.1 - 7e-10 38.5 0.5 2.5e-09 36.7 0.1 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 KOG96289.1 - 1.3e-08 35.1 0.1 1.2e-06 28.7 0.0 2.3 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 KOG96289.1 - 5.5e-07 28.9 0.3 7.2e-05 21.9 0.0 2.5 3 0 0 3 3 3 1 Thi4 family NAD_binding_8 PF13450.1 KOG96289.1 - 4.2e-06 26.6 3.4 0.009 16.0 0.5 3.1 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.13 KOG96289.1 - 8.6e-06 25.5 0.8 0.00052 19.7 0.0 2.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.14 KOG96289.1 - 1.4e-05 24.3 0.4 0.016 14.2 0.1 2.4 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.9 KOG96289.1 - 4.8e-05 22.0 3.6 0.0092 14.4 0.1 3.6 3 1 1 4 4 4 1 HI0933-like protein FAD_binding_2 PF00890.19 KOG96289.1 - 5.1e-05 22.2 1.4 8.3e-05 21.5 0.4 1.7 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.17 KOG96289.1 - 0.00025 20.0 4.5 0.015 14.1 0.3 3.0 3 0 0 3 3 3 1 Glucose inhibited division protein A Lycopene_cycl PF05834.7 KOG96289.1 - 0.001 18.0 0.3 0.015 14.2 0.1 2.4 2 1 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.19 KOG96289.1 - 0.0024 16.8 7.6 0.27 10.0 0.5 3.7 2 1 2 4 4 4 1 FAD dependent oxidoreductase K_oxygenase PF13434.1 KOG96289.1 - 0.0024 16.8 1.0 1.1 8.1 0.0 3.0 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) 2-Hacid_dh_C PF02826.14 KOG96289.1 - 0.0095 15.1 0.2 0.039 13.1 0.0 2.0 2 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XdhC_C PF13478.1 KOG96289.1 - 0.012 15.9 0.0 3.5 7.9 0.0 3.0 2 1 0 3 3 3 0 XdhC Rossmann domain TrkA_N PF02254.13 KOG96289.1 - 0.013 15.5 0.1 0.08 12.9 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_7 PF13241.1 KOG96289.1 - 0.017 15.3 0.0 0.48 10.7 0.0 2.7 2 1 0 2 2 2 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.16 KOG96289.1 - 0.027 14.0 0.8 0.075 12.5 0.0 2.1 3 0 0 3 3 2 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.9 KOG96289.1 - 0.04 13.2 0.1 0.22 10.9 0.0 2.3 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ARID PF01388.16 KOG96290.1 - 4.4e-23 80.9 0.8 4.4e-23 80.9 0.6 3.6 3 1 0 3 3 3 1 ARID/BRIGHT DNA binding domain Hom_end_hint PF05203.11 KOG96290.1 - 1.3 8.7 27.6 0.43 10.2 9.5 2.9 3 0 0 3 3 3 0 Hom_end-associated Hint SIR2 PF02146.12 KOG96291.1 - 8.6e-52 175.4 0.0 3e-50 170.3 0.0 2.3 1 1 0 1 1 1 1 Sir2 family Ribosomal_S16 PF00886.14 KOG96293.1 - 4.5e-27 93.5 0.2 6e-27 93.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 PDR_assoc PF08370.6 KOG96293.1 - 0.086 12.3 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Plant PDR ABC transporter associated NUC173 PF08161.7 KOG96294.1 - 7.9e-74 247.3 0.2 8.4e-72 240.6 0.2 3.1 2 0 0 2 2 2 2 NUC173 domain HEAT PF02985.17 KOG96294.1 - 0.0086 16.0 1.8 4.7 7.5 0.0 5.0 5 0 0 5 5 5 1 HEAT repeat Bromo_TP PF07524.8 KOG96295.1 - 3.1e-09 36.4 0.1 7.5e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated Clat_adaptor_s PF01217.15 KOG96296.1 - 1.2e-17 63.9 0.5 1.8e-17 63.3 0.3 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF3441 PF11923.3 KOG96297.1 - 1.9e-34 117.6 1.0 1.9e-34 117.6 0.7 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3441) FbpA PF05833.6 KOG96297.1 - 6.9e-26 90.7 29.5 6.9e-26 90.7 20.4 3.5 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) DUF814 PF05670.8 KOG96297.1 - 1.1e-09 38.0 0.0 2.8e-09 36.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF814) DEAD_2 PF06733.10 KOG96298.1 - 6.8e-50 168.8 0.4 1.5e-49 167.7 0.0 1.8 2 0 0 2 2 2 1 DEAD_2 Helicase_C_2 PF13307.1 KOG96298.1 - 2.3e-48 164.3 0.0 5.5e-48 163.0 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.10 KOG96298.1 - 0.001 18.9 3.1 0.053 13.3 0.1 3.1 2 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.24 KOG96298.1 - 0.0018 17.7 0.0 0.34 10.3 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase AAA_22 PF13401.1 KOG96298.1 - 0.0021 18.2 0.2 1.4 9.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.1 KOG96298.1 - 0.068 12.7 0.2 0.16 11.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain PhoH PF02562.11 KOG96298.1 - 0.099 11.8 1.8 1.7 7.7 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein zf-TFIIIC PF12660.2 KOG96299.1 - 1.7e-08 34.2 0.0 3.6e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex Patched PF02460.13 KOG96300.1 - 2e-65 221.2 13.4 6.9e-63 212.8 9.3 2.5 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.3 KOG96300.1 - 3e-39 133.9 4.3 3e-39 133.9 3.0 2.9 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.14 KOG96300.1 - 8.3e-07 26.8 25.2 8.5e-07 26.7 12.8 2.7 3 0 0 3 3 3 2 AcrB/AcrD/AcrF family PPR_2 PF13041.1 KOG96301.1 - 4.1e-13 49.0 2.7 7.7e-07 28.9 0.0 4.1 4 0 0 4 4 4 2 PPR repeat family PPR_3 PF13812.1 KOG96301.1 - 1.8e-05 24.6 0.0 5 7.6 0.0 5.4 5 0 0 5 5 5 1 Pentatricopeptide repeat domain PPR_1 PF12854.2 KOG96301.1 - 0.0025 17.2 0.0 0.12 11.8 0.0 3.2 3 0 0 3 3 3 1 PPR repeat Pil1 PF13805.1 KOG96302.1 - 2.3e-151 502.4 0.8 2.8e-151 502.2 0.6 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 PCP_red PF08369.5 KOG96302.1 - 0.05 13.4 1.4 0.14 12.0 0.1 2.4 3 0 0 3 3 3 0 Proto-chlorophyllide reductase 57 kD subunit EAP30 PF04157.11 KOG96304.1 - 4.9e-49 166.4 0.2 5.4e-49 166.3 0.1 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Hat1_N PF10394.4 KOG96305.1 - 1.9e-34 119.0 2.3 1.9e-34 119.0 1.6 1.6 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_10 PF13673.1 KOG96305.1 - 0.0005 20.1 0.0 0.00083 19.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 KOG96305.1 - 0.0016 18.4 0.0 0.0037 17.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOG96305.1 - 0.0041 17.2 0.0 0.0079 16.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KOG96305.1 - 0.037 14.1 0.0 0.068 13.3 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Citrate_synt PF00285.16 KOG96306.1 - 1.9e-94 316.3 0.0 2.2e-94 316.1 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase RVT_2 PF07727.9 KOG96307.1 - 8.7e-35 119.8 0.3 1.6e-34 118.9 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KOG96307.1 - 1.2e-19 70.5 0.1 3.4e-19 69.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain DUF2481 PF10654.4 KOG96307.1 - 0.025 14.2 4.2 0.035 13.8 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2481) Sulfate_transp PF00916.15 KOG96308.1 - 2.5e-64 217.0 8.8 4.2e-64 216.2 6.1 1.3 1 0 0 1 1 1 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 KOG96308.1 - 6.4e-27 93.0 3.7 6.4e-27 93.0 2.6 2.4 2 0 0 2 2 2 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 KOG96308.1 - 2.5e-23 81.7 0.1 6.8e-23 80.3 0.0 1.7 1 0 0 1 1 1 1 STAS domain Spore_YabQ PF09578.5 KOG96308.1 - 0.43 10.5 10.2 1 9.3 1.0 3.1 3 0 0 3 3 3 0 Spore cortex protein YabQ (Spore_YabQ) Ost4 PF10215.4 KOG96308.1 - 1.8 8.1 7.4 0.82 9.2 0.2 2.7 2 0 0 2 2 2 0 Oligosaccaryltransferase ETF_alpha PF00766.14 KOG96309.1 - 3.6e-32 109.8 0.0 6.8e-32 108.9 0.0 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.16 KOG96309.1 - 4.9e-32 110.9 0.0 1.2e-31 109.6 0.0 1.6 2 0 0 2 2 2 1 Electron transfer flavoprotein domain SR-25 PF10500.4 KOG96310.1 - 0.022 14.2 8.7 0.037 13.5 6.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Dala_Dala_lig_N PF01820.16 KOG96310.1 - 0.27 11.5 1.3 0.46 10.7 0.9 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase N-terminus ICL PF00463.16 KOG96311.1 - 1e-171 571.7 0.0 1.2e-171 571.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 KOG96311.1 - 9.5e-09 34.8 0.0 1.4e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Rad21_Rec8_N PF04825.8 KOG96312.1 - 4e-18 65.3 1.2 9.1e-17 61.0 0.9 2.4 1 1 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 KOG96312.1 - 0.064 12.4 0.0 0.19 10.9 0.0 1.8 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein Copper-fist PF00649.13 KOG96313.1 - 3e-22 77.5 1.1 8e-22 76.1 0.8 1.8 1 0 0 1 1 1 1 Copper fist DNA binding domain Zn_clus PF00172.13 KOG96314.1 - 0.00056 19.7 11.0 0.0012 18.7 1.9 2.6 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain RNA_pol_Rpb2_6 PF00562.23 KOG96315.1 - 2.9e-115 385.0 0.0 4.3e-115 384.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 KOG96315.1 - 1e-54 184.5 0.1 1.5e-54 184.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 KOG96315.1 - 3.6e-39 134.1 0.0 1e-38 132.6 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.11 KOG96315.1 - 1e-24 86.0 0.0 5.7e-24 83.6 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.7 KOG96315.1 - 8.7e-23 80.0 0.0 1.8e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.15 KOG96315.1 - 4.6e-16 58.8 0.0 3.5e-15 56.0 0.0 2.3 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_5 PF04567.12 KOG96315.1 - 4.2e-05 23.4 0.1 9e-05 22.3 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Mito_carr PF00153.22 KOG96317.1 - 1e-75 249.5 1.3 2.4e-27 94.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-C2H2 PF00096.21 KOG96318.1 - 2.1e-09 37.1 9.1 0.00026 21.1 0.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG96318.1 - 4.5e-06 26.6 6.5 0.0066 16.7 0.6 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 KOG96318.1 - 0.00061 19.9 5.7 0.0056 16.8 0.3 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.1 KOG96318.1 - 0.0018 18.4 0.3 0.0018 18.4 0.2 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-BED PF02892.10 KOG96318.1 - 0.015 14.9 6.1 0.033 13.9 0.8 2.4 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_jaz PF12171.3 KOG96318.1 - 0.12 12.5 6.0 0.42 10.8 0.0 2.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.1 KOG96318.1 - 0.4 10.9 9.6 2.2 8.6 0.4 3.3 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2 PF00096.21 KOG96319.1 - 2.1e-10 40.3 11.8 4.3e-05 23.5 0.9 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KOG96319.1 - 4.5e-08 32.9 9.7 7.3e-05 22.8 0.7 3.9 3 1 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOG96319.1 - 7.8e-07 28.9 11.0 0.00062 19.9 0.8 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 KOG96319.1 - 8.6e-05 22.6 6.7 0.0031 17.6 0.2 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KOG96319.1 - 0.0039 17.2 5.6 0.44 10.7 0.0 2.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 KOG96319.1 - 0.1 12.3 9.8 1.1 9.0 0.5 2.5 1 1 1 2 2 2 0 BED zinc finger zf-C2HC_2 PF13913.1 KOG96319.1 - 3 7.6 6.6 19 5.0 1.1 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type eIF-6 PF01912.13 KOG96320.1 - 3.5e-85 284.1 0.5 4.4e-85 283.7 0.3 1.1 1 0 0 1 1 1 1 eIF-6 family Mss4 PF04421.8 KOG96321.1 - 1e-24 86.1 0.1 2.5e-24 84.9 0.0 1.6 1 1 0 1 1 1 1 Mss4 protein CAF1A PF12253.3 KOG96322.1 - 1.3e-22 79.6 8.6 1.3e-22 79.6 6.0 2.6 2 0 0 2 2 2 1 Chromatin assembly factor 1 subunit A CAF-1_p150 PF11600.3 KOG96322.1 - 2.1e-14 53.4 56.7 2.1e-14 53.4 39.3 2.4 3 0 0 3 3 3 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal MCM PF00493.18 KOG96323.1 - 5.1e-140 465.9 0.1 7.4e-140 465.4 0.1 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 KOG96323.1 - 2e-22 79.9 1.4 2e-22 79.9 1.0 2.6 3 0 0 3 3 3 1 MCM N-terminal domain AAA_5 PF07728.9 KOG96323.1 - 1.2e-06 28.3 0.0 2.6e-05 23.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 KOG96323.1 - 8.9e-06 25.0 0.0 0.00035 19.8 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 KOG96323.1 - 0.0021 17.6 0.0 0.0069 15.9 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 KOG96323.1 - 0.091 12.2 0.1 5 6.5 0.0 3.3 3 0 0 3 3 3 0 Sigma-54 interaction domain ATP-synt_G PF04718.10 KOG96324.1 - 4.5e-31 107.5 0.8 5.2e-31 107.3 0.6 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit DUF2743 PF10899.3 KOG96324.1 - 0.032 13.5 0.4 0.042 13.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2743) Mito_carr PF00153.22 KOG96325.1 - 2.8e-75 248.1 0.1 1.6e-25 88.6 0.0 3.7 4 0 0 4 4 4 3 Mitochondrial carrier protein Fungal_trans PF04082.13 KOG96326.1 - 1.6e-73 246.7 3.1 6.3e-73 244.8 2.1 2.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2_4 PF13894.1 KOG96326.1 - 4.4e-07 29.7 10.4 0.00091 19.3 3.3 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 KOG96326.1 - 2.2e-05 24.5 17.1 0.0013 18.9 3.3 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type Mem_trans PF03547.13 KOG96326.1 - 0.14 10.4 2.2 0.19 9.9 1.5 1.4 1 0 0 1 1 1 0 Membrane transport protein MRG PF05712.8 KOG96327.1 - 1e-50 171.3 0.7 1.7e-50 170.6 0.5 1.3 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.3 KOG96327.1 - 2.5e-06 27.0 0.3 8.2e-06 25.4 0.2 1.9 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain Macoilin PF09726.4 KOG96327.1 - 0.074 11.3 7.7 0.094 10.9 5.3 1.1 1 0 0 1 1 1 0 Transmembrane protein Peptidase_M41 PF01434.13 KOG96328.1 - 2e-71 239.8 0.3 3.1e-71 239.2 0.2 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 KOG96328.1 - 9.6e-41 139.0 0.0 2.1e-40 137.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOG96328.1 - 4e-05 23.6 0.5 0.0002 21.3 0.1 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOG96328.1 - 4.9e-05 23.4 0.7 0.024 14.7 0.1 3.0 2 1 0 2 2 1 1 AAA domain TIP49 PF06068.8 KOG96328.1 - 0.00022 20.0 0.0 0.00039 19.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_17 PF13207.1 KOG96328.1 - 0.00032 21.4 0.0 0.0013 19.5 0.0 2.1 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOG96328.1 - 0.00064 18.8 0.0 0.0026 16.8 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 KOG96328.1 - 0.0015 18.2 1.5 0.004 16.8 1.1 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 KOG96328.1 - 0.003 17.2 0.1 0.0099 15.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 KOG96328.1 - 0.0049 16.3 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.1 KOG96328.1 - 0.0065 15.9 1.3 0.12 11.7 0.4 2.3 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 KOG96328.1 - 0.0092 16.2 0.2 0.062 13.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 KOG96328.1 - 0.017 14.1 0.1 0.04 12.9 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 KOG96328.1 - 0.019 14.8 0.0 0.072 12.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain SpoU_sub_bind PF08032.7 KOG96328.1 - 0.031 14.4 0.2 20 5.4 0.2 3.3 3 0 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding AAA_33 PF13671.1 KOG96328.1 - 0.034 14.0 0.0 0.12 12.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 KOG96328.1 - 0.045 12.9 0.2 0.1 11.7 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI KaiC PF06745.8 KOG96328.1 - 0.05 12.7 0.0 0.42 9.6 0.0 2.2 2 0 0 2 2 2 0 KaiC PhoH PF02562.11 KOG96328.1 - 0.1 11.7 0.5 0.3 10.2 0.2 1.8 2 0 0 2 2 2 0 PhoH-like protein Cyclin_N PF00134.18 KOG96329.1 - 3.8e-11 42.6 4.5 1.1e-10 41.1 0.7 2.5 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.14 KOG96329.1 - 0.0014 18.3 0.0 0.003 17.3 0.0 1.6 1 0 0 1 1 1 1 Transcription factor TFIIB repeat OAD_gamma PF04277.8 KOG96329.1 - 2.4 8.6 5.3 3.9 7.9 0.2 2.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Glyco_hydro_65m PF03632.10 KOG96330.1 - 3.9e-104 348.2 1.9 1.8e-103 346.1 1.3 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.10 KOG96330.1 - 1.9e-66 223.9 0.1 4.5e-66 222.7 0.1 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65C PF03633.10 KOG96330.1 - 1.1e-13 51.0 0.4 3.2e-13 49.5 0.1 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 65, C-terminal domain GATA PF00320.22 KOG96331.1 - 1.5e-12 46.6 5.5 3.3e-12 45.5 3.6 1.7 2 0 0 2 2 2 1 GATA zinc finger ArfGap PF01412.13 KOG96331.1 - 0.064 13.0 0.2 0.24 11.2 0.1 1.9 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Adaptin_N PF01602.15 KOG96333.1 - 8.6e-132 440.1 20.1 1.2e-131 439.6 13.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 KOG96333.1 - 1.3e-12 47.9 0.0 2.8e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Suf PF05843.9 KOG96333.1 - 0.0059 16.3 1.6 0.011 15.4 1.1 1.4 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Arrestin_C PF02752.17 KOG96334.1 - 9.1e-17 61.4 0.0 6.7e-15 55.3 0.0 3.3 2 2 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 KOG96334.1 - 0.00057 19.7 0.2 0.0019 18.0 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain zf-HC5HC2H_2 PF13832.1 KOG96335.1 - 2.5e-31 107.9 11.2 2.5e-31 107.9 7.7 3.0 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 KOG96335.1 - 7e-27 93.4 8.8 7e-27 93.4 6.1 3.6 3 1 1 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.1 KOG96335.1 - 5e-13 48.1 1.8 5e-13 48.1 1.3 3.2 3 0 0 3 3 3 1 PHD-finger EPL1 PF10513.4 KOG96335.1 - 5.3e-10 39.7 2.0 1.3e-09 38.5 1.4 1.7 1 0 0 1 1 1 1 Enhancer of polycomb-like PHD PF00628.24 KOG96335.1 - 1.2e-09 37.6 4.0 1.2e-09 37.6 2.7 3.1 4 0 0 4 4 4 2 PHD-finger RcsC PF09456.5 KOG96335.1 - 0.058 13.0 0.0 17 5.0 0.0 2.8 2 0 0 2 2 2 0 RcsC Alpha-Beta-Loop (ABL) C1_1 PF00130.17 KOG96335.1 - 0.092 12.4 0.2 0.092 12.4 0.1 3.2 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.6 KOG96335.1 - 4.1 7.4 25.7 0.28 11.2 1.1 3.0 3 0 0 3 3 3 0 RING-like domain Prok-RING_1 PF14446.1 KOG96335.1 - 5.3 6.8 27.1 0.87 9.3 1.8 3.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Lgl_C PF08596.5 KOG96336.1 - 1.4e-149 497.8 0.2 5.6e-149 495.8 0.0 2.0 2 1 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal tRNA-synt_His PF13393.1 KOG96337.1 - 1.6e-40 139.0 0.0 1.7e-39 135.7 0.0 2.0 1 1 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 KOG96337.1 - 9.5e-19 67.6 0.0 2.3e-18 66.3 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KOG96337.1 - 2.5e-11 43.3 0.0 5e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.15 KOG96337.1 - 0.00033 19.5 0.0 0.014 14.1 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 KOG96337.1 - 0.023 13.9 0.0 0.052 12.7 0.0 1.6 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) Ribosomal_60s PF00428.14 KOG96337.1 - 9.7 6.6 10.6 2.3 8.6 0.3 3.3 3 0 0 3 3 3 0 60s Acidic ribosomal protein Actin PF00022.14 KOG96338.1 - 3e-51 174.0 0.1 9.1e-51 172.4 0.1 1.7 1 1 0 1 1 1 1 Actin TMCO5 PF14992.1 KOG96338.1 - 0.012 14.7 1.9 0.018 14.1 1.3 1.2 1 0 0 1 1 1 0 TMCO5 family MreB_Mbl PF06723.8 KOG96338.1 - 0.092 11.3 0.1 4.4 5.8 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein Gln-synt_C PF00120.19 KOG96339.1 - 3.4e-63 213.1 0.0 4.1e-63 212.9 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 KOG96339.1 - 3.4e-20 71.4 0.0 1.1e-19 69.7 0.0 1.8 2 0 0 2 2 2 1 Glutamine synthetase, beta-Grasp domain V-ATPase_H_N PF03224.9 KOG96340.1 - 2.8e-65 220.4 12.4 5.2e-65 219.5 8.6 1.4 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 KOG96340.1 - 4.3e-40 136.3 0.1 4.3e-40 136.3 0.1 3.1 3 1 1 4 4 4 1 V-ATPase subunit H Evr1_Alr PF04777.8 KOG96342.1 - 3.8e-24 84.3 1.4 4.2e-24 84.2 0.1 1.7 2 0 0 2 2 2 1 Erv1 / Alr family Na_sulph_symp PF00939.14 KOG96342.1 - 0.0069 15.3 0.0 0.0096 14.8 0.0 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region TIP41 PF04176.8 KOG96343.1 - 1e-71 239.9 2.1 1.4e-71 239.4 1.5 1.2 1 0 0 1 1 1 1 TIP41-like family eIF-5_eIF-2B PF01873.12 KOG96344.1 - 3.9e-43 146.0 0.0 1e-42 144.6 0.0 1.7 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.13 KOG96344.1 - 3.6e-26 90.9 4.1 1.1e-25 89.3 0.0 2.8 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon PUF PF00806.14 KOG96345.1 - 2.8e-31 105.2 6.6 0.00011 21.4 0.0 6.6 6 0 0 6 6 6 6 Pumilio-family RNA binding repeat RRM_1 PF00076.17 KOG96345.1 - 3.7e-06 26.4 0.0 8.7e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96345.1 - 8.3e-05 22.3 0.0 0.0002 21.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG96345.1 - 0.062 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L37ae PF01780.14 KOG96346.1 - 9.6e-40 134.3 9.2 1.1e-39 134.2 6.4 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family DUF1364 PF07102.7 KOG96346.1 - 0.0044 16.8 0.9 0.0055 16.5 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1364) Rep_fac-A_C PF08646.5 KOG96346.1 - 0.006 16.2 0.4 0.0073 16.0 0.3 1.2 1 0 0 1 1 1 1 Replication factor-A C terminal domain Zn_Tnp_IS1595 PF12760.2 KOG96346.1 - 0.017 14.8 2.7 0.028 14.2 1.9 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Sgf11 PF08209.6 KOG96346.1 - 0.019 14.2 0.6 0.4 10.0 0.0 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) C1_1 PF00130.17 KOG96346.1 - 0.049 13.3 1.7 0.074 12.7 1.2 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CarbpepA_inh PF02977.10 KOG96346.1 - 0.053 13.1 3.9 0.11 12.1 0.5 2.1 1 1 1 2 2 2 0 Carboxypeptidase A inhibitor zf-H2C2_2 PF13465.1 KOG96346.1 - 0.13 12.6 1.2 1.3 9.3 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zf-C4_ClpX PF06689.8 KOG96346.1 - 0.15 11.6 0.3 0.15 11.6 0.2 2.1 2 0 0 2 2 2 0 ClpX C4-type zinc finger zinc_ribbon_2 PF13240.1 KOG96346.1 - 0.17 11.4 1.6 0.9 9.1 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 KOG96346.1 - 0.21 11.2 3.0 0.32 10.6 2.0 1.4 1 1 0 1 1 1 0 Putative transposase DNA-binding domain Elf1 PF05129.8 KOG96346.1 - 0.22 11.2 2.7 0.5 10.0 1.8 1.7 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like A2L_zn_ribbon PF08792.5 KOG96346.1 - 0.43 10.1 2.3 9.7 5.7 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain SAC3_GANP PF03399.11 KOG96347.1 - 2.7e-50 170.7 7.0 3.9e-50 170.2 4.9 1.2 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family Cyc-maltodext_N PF09087.6 KOG96348.1 - 0.12 12.3 0.7 0.62 10.0 0.2 2.1 2 0 0 2 2 2 0 Cyclomaltodextrinase, N-terminal APG6 PF04111.7 KOG96348.1 - 5.3 5.9 12.2 0.55 9.2 4.8 1.9 1 1 1 2 2 2 0 Autophagy protein Apg6 tRNA-synt_2d PF01409.15 KOG96349.1 - 1.2e-47 162.2 0.1 2.1e-26 92.6 0.0 2.4 2 1 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.9 KOG96349.1 - 6e-27 93.6 0.0 1.2e-25 89.4 0.0 2.8 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain DUF3811 PF11656.3 KOG96349.1 - 0.035 14.1 0.0 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 YjbD family (DUF3811) FAD_binding_1 PF00667.15 KOG96350.1 - 6.2e-34 117.3 0.0 1.7e-33 115.9 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 KOG96350.1 - 9.3e-22 77.5 0.0 2.5e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 KOG96350.1 - 2.4e-12 47.3 0.0 1.2e-11 45.1 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_NdrI PF07972.6 KOG96350.1 - 0.019 14.8 0.0 0.054 13.4 0.0 1.8 1 0 0 1 1 1 0 NrdI Flavodoxin like UCR_6-4kD PF08997.5 KOG96350.1 - 0.25 11.0 1.7 0.67 9.7 1.2 1.7 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein ATG11 PF10377.4 KOG96351.1 - 1.5e-40 138.0 2.0 2.4e-40 137.4 0.0 2.4 2 0 0 2 2 2 1 Autophagy-related protein 11 Cytochrom_B562 PF07361.6 KOG96351.1 - 0.12 12.8 0.1 0.12 12.8 0.0 5.5 5 1 0 5 5 5 0 Cytochrome b562 Reo_sigmaC PF04582.7 KOG96351.1 - 0.51 9.4 21.0 0.78 8.8 2.2 4.2 2 2 2 4 4 4 0 Reovirus sigma C capsid protein Atg14 PF10186.4 KOG96351.1 - 2.6 6.9 32.5 3.7 6.4 6.4 4.0 2 1 1 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 Acetyltransf_1 PF00583.19 KOG96352.1 - 5.2e-19 68.0 0.0 7.9e-19 67.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOG96352.1 - 3.3e-08 33.5 0.0 5.6e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 KOG96352.1 - 1.9e-07 31.1 0.0 2.2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOG96352.1 - 5.4e-07 29.2 0.1 8.6e-07 28.6 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.1 KOG96352.1 - 1.2e-06 28.7 0.0 1.4e-06 28.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOG96352.1 - 4.2e-05 23.6 0.0 5.7e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 KOG96352.1 - 0.00052 19.8 0.1 0.003 17.4 0.1 2.0 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 KOG96352.1 - 0.0035 17.1 0.0 0.0071 16.2 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase DUF1248 PF06852.7 KOG96352.1 - 0.14 11.3 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1248) HMG_box PF00505.14 KOG96353.1 - 1e-26 93.0 2.5 1e-26 93.0 1.8 1.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOG96353.1 - 3.5e-20 72.1 2.4 4.9e-20 71.6 1.7 1.2 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.1 KOG96353.1 - 0.0037 17.0 1.4 0.0042 16.8 0.2 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box 5 YABBY PF04690.8 KOG96353.1 - 0.11 12.7 0.6 0.14 12.4 0.3 1.3 1 1 0 1 1 1 0 YABBY protein Pkinase PF00069.20 KOG96354.1 - 2e-60 204.1 0.0 2.5e-60 203.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96354.1 - 2.1e-29 102.3 0.0 2.9e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sec8_exocyst PF04048.9 KOG96355.1 - 2.3e-49 166.6 3.4 2.3e-49 166.6 2.4 3.6 4 0 0 4 4 4 1 Sec8 exocyst complex component specific domain Sec5 PF15469.1 KOG96355.1 - 0.00015 21.5 11.9 0.00015 21.5 8.3 3.3 3 0 0 3 3 3 1 Exocyst complex component Sec5 Tfb4 PF03850.9 KOG96356.1 - 8.3e-105 349.9 0.3 9.6e-105 349.7 0.2 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 VWA_2 PF13519.1 KOG96356.1 - 0.0041 17.2 0.1 0.0054 16.8 0.1 1.3 1 1 0 1 1 1 1 von Willebrand factor type A domain DUF737 PF05300.6 KOG96356.1 - 0.015 15.2 0.1 0.02 14.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) Med11 PF10280.4 KOG96356.1 - 0.022 14.8 0.2 0.038 14.0 0.1 1.3 1 0 0 1 1 1 0 Mediator complex protein SIP1 PF04938.7 KOG96357.1 - 3.6e-06 26.5 1.0 0.00012 21.5 0.1 2.7 2 1 0 2 2 2 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) DUF3014 PF11219.3 KOG96357.1 - 0.0018 18.1 0.0 0.004 17.0 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3014) DUF3919 PF13057.1 KOG96357.1 - 0.016 14.6 3.3 0.02 14.3 1.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3919) Mito_carr PF00153.22 KOG96358.1 - 1.8e-61 203.8 1.1 1.7e-21 75.7 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein CM_2 PF01817.16 KOG96359.1 - 5.8e-15 55.1 0.2 7.3e-09 35.5 0.0 3.3 2 1 1 3 3 3 3 Chorismate mutase type II Baculo_FP PF03258.9 KOG96359.1 - 0.038 13.1 3.6 0.058 12.4 0.9 2.0 2 0 0 2 2 2 0 Baculovirus FP protein DnaJ PF00226.26 KOG96360.1 - 7.3e-18 64.0 0.6 1.3e-17 63.3 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain dCMP_cyt_deam_1 PF00383.17 KOG96361.1 - 6.8e-23 80.2 0.0 9.2e-23 79.8 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.1 KOG96361.1 - 0.00048 19.9 0.4 0.0025 17.6 0.2 1.9 1 1 1 2 2 2 1 Bd3614-like deaminase XOO_2897-deam PF14440.1 KOG96361.1 - 0.026 14.2 0.0 0.032 13.9 0.0 1.4 1 1 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase HMG_box PF00505.14 KOG96363.1 - 1.1e-17 63.9 1.3 2.9e-17 62.6 0.9 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOG96363.1 - 3e-06 27.4 0.1 3e-06 27.4 0.1 2.0 2 0 0 2 2 2 1 HMG-box domain Neisseria_TspB PF05616.8 KOG96363.1 - 0.21 9.8 5.2 0.38 9.0 3.6 1.3 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein DUF4175 PF13779.1 KOG96363.1 - 0.26 8.9 17.6 0.32 8.6 12.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) BAF1_ABF1 PF04684.8 KOG96363.1 - 1.4 7.6 20.4 2.2 7.0 14.1 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor ThiF PF00899.16 KOG96364.1 - 4.8e-34 117.1 0.0 7.7e-34 116.4 0.0 1.3 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 KOG96364.1 - 1e-14 53.8 0.9 2.9e-14 52.3 0.1 2.0 2 0 0 2 2 2 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 KOG96364.1 - 1.3e-08 34.0 2.4 2.6e-08 33.1 1.7 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.15 KOG96364.1 - 0.0074 16.3 0.0 0.019 15.0 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Ldh_1_N PF00056.18 KOG96364.1 - 0.04 13.7 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 KOG96364.1 - 0.059 12.3 0.0 0.1 11.5 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase Pyr_redox PF00070.22 KOG96364.1 - 0.15 12.4 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fe-S_biosyn PF01521.15 KOG96365.1 - 4.2e-13 49.2 0.0 8.8e-12 44.9 0.0 2.2 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis Hist_deacetyl PF00850.14 KOG96366.1 - 2.5e-67 227.3 0.0 3.6e-67 226.8 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Spermine_synth PF01564.12 KOG96367.1 - 3.9e-102 340.4 0.0 4.7e-102 340.1 0.0 1.0 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_31 PF13847.1 KOG96367.1 - 0.0012 18.5 0.0 0.0018 17.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOG96367.1 - 0.012 16.0 0.1 0.056 13.9 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 KOG96367.1 - 0.024 15.2 0.0 0.044 14.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 KOG96367.1 - 0.025 14.3 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Med1 PF10744.4 KOG96368.1 - 2.1e-79 267.1 20.9 4.7e-79 265.9 14.5 1.6 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 Not3 PF04065.10 KOG96369.1 - 8.6e-82 273.8 38.8 1.4e-79 266.6 23.4 3.3 2 1 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 KOG96369.1 - 4.8e-26 91.2 8.5 4.8e-26 91.2 5.9 4.4 5 1 0 5 5 5 1 NOT2 / NOT3 / NOT5 family Cep57_MT_bd PF06657.8 KOG96369.1 - 1.5 8.8 11.4 0.096 12.6 2.8 2.8 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Ish1 PF10281.4 KOG96369.1 - 1.6 8.9 11.0 5.2 7.2 0.0 4.3 4 0 0 4 4 4 0 Putative stress-responsive nuclear envelope protein LMWPc PF01451.16 KOG96370.1 - 7.8e-45 152.5 0.0 8.8e-45 152.4 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Transketolase_N PF00456.16 KOG96371.1 - 3e-157 522.6 0.0 6.7e-157 521.5 0.0 1.6 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 KOG96371.1 - 1.8e-46 157.8 0.0 3.2e-46 157.0 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 KOG96371.1 - 1.4e-16 60.5 0.0 3.9e-16 59.1 0.0 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.1 KOG96371.1 - 1.1e-05 24.5 0.0 0.00013 20.9 0.0 2.2 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.16 KOG96371.1 - 0.0013 18.2 0.4 0.025 14.1 0.3 2.4 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.15 KOG96371.1 - 0.0031 16.2 0.0 0.0067 15.1 0.0 1.5 1 0 0 1 1 1 1 Dehydrogenase E1 component Opy2 PF09463.5 KOG96372.1 - 8e-10 38.6 18.8 1.2e-09 38.0 13.0 1.3 1 0 0 1 1 1 1 Opy2 protein DUF1510 PF07423.6 KOG96372.1 - 0.00037 19.9 0.1 0.00037 19.9 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1510) Herpes_gE PF02480.11 KOG96372.1 - 0.00059 18.2 0.0 0.0012 17.1 0.0 1.5 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E FLO_LFY PF01698.11 KOG96372.1 - 0.11 11.3 5.5 1.4 7.6 0.5 2.1 2 0 0 2 2 2 0 Floricaula / Leafy protein SID-1_RNA_chan PF13965.1 KOG96372.1 - 0.15 10.1 0.4 0.25 9.4 0.0 1.5 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 LRR19-TM PF15176.1 KOG96372.1 - 0.18 11.4 1.2 1.7 8.3 0.0 2.5 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain TFIIA PF03153.8 KOG96372.1 - 0.29 10.9 19.7 0.28 11.0 3.0 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.7 KOG96372.1 - 0.45 10.1 22.4 0.06 13.0 3.0 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.9 KOG96372.1 - 9.4 4.1 17.3 0.036 12.1 0.8 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF2200 PF09966.4 KOG96373.1 - 0.011 15.5 0.2 0.022 14.6 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2200) DUF4509 PF14970.1 KOG96373.1 - 0.26 10.9 4.1 0.37 10.4 1.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4509) Syntaxin PF00804.20 KOG96373.1 - 5.3 7.2 9.3 2.6 8.2 3.8 2.3 2 0 0 2 2 2 0 Syntaxin CIMR PF00878.13 KOG96374.1 - 6e-09 35.8 1.4 8e-05 22.4 0.2 3.0 2 1 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat PRKCSH_1 PF13015.1 KOG96374.1 - 1.8e-05 24.2 0.1 2.9e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein GTP_EFTU PF00009.22 KOG96375.1 - 5.9e-57 192.1 0.1 8.9e-57 191.5 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 KOG96375.1 - 1.5e-35 121.2 0.0 4.8e-35 119.6 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 KOG96375.1 - 6.4e-17 61.4 2.2 6.4e-17 61.4 1.5 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 KOG96375.1 - 2.7e-05 23.6 0.6 2.7e-05 23.6 0.4 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 KOG96375.1 - 0.0012 18.8 0.3 0.0037 17.2 0.2 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase tRNA-synt_2b PF00587.20 KOG96376.1 - 5.1e-67 224.7 0.1 2.5e-66 222.5 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KOG96376.1 - 9.7e-23 79.9 0.4 6.1e-22 77.3 0.2 2.3 2 0 0 2 2 2 1 Anticodon binding domain DIM1 PF02966.11 KOG96377.1 - 3.2e-68 227.3 0.6 3.6e-68 227.1 0.4 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 DUF2384 PF09722.5 KOG96378.1 - 0.36 10.7 0.1 0.36 10.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2384) MMR_HSR1 PF01926.18 KOG96379.1 - 0.00054 19.9 0.0 0.075 13.0 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 KOG96379.1 - 0.001 18.8 0.5 1.3 8.8 0.0 2.7 3 0 0 3 3 3 2 Dynamin family Miro PF08477.8 KOG96379.1 - 0.0012 19.3 0.0 0.043 14.3 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein Ras PF00071.17 KOG96379.1 - 0.0053 16.1 0.0 0.71 9.2 0.0 2.4 2 0 0 2 2 2 2 Ras family AAA_28 PF13521.1 KOG96379.1 - 0.016 15.1 0.1 0.041 13.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain WD40 PF00400.27 KOG96380.1 - 0.0002 21.0 2.8 0.19 11.6 0.1 4.0 3 0 0 3 3 3 3 WD domain, G-beta repeat TFIIB PF00382.14 KOG96381.1 - 3.7e-44 148.3 2.7 3e-28 97.4 0.7 2.7 3 0 0 3 3 3 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 KOG96381.1 - 2.9e-13 48.9 0.6 5.1e-13 48.1 0.4 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding DUF1456 PF07308.8 KOG96381.1 - 0.39 10.7 3.0 1.4 9.0 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) OrfB_Zn_ribbon PF07282.6 KOG96381.1 - 0.39 10.3 2.9 65 3.2 0.1 3.3 3 0 0 3 3 3 0 Putative transposase DNA-binding domain SRP54 PF00448.17 KOG96382.1 - 8.2e-80 266.8 0.5 8.2e-80 266.8 0.3 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 KOG96382.1 - 1.6e-24 86.1 13.2 1.6e-24 86.1 9.2 4.7 4 1 1 5 5 3 1 Signal peptide binding domain SRP54_N PF02881.14 KOG96382.1 - 4.9e-17 61.7 2.6 1.9e-16 59.9 1.8 2.1 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.14 KOG96382.1 - 4.5e-06 26.2 1.6 2.4e-05 23.8 0.3 2.5 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_31 PF13614.1 KOG96382.1 - 7.6e-06 25.9 0.0 0.035 14.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain CbiA PF01656.18 KOG96382.1 - 9.5e-06 25.1 1.4 3.4e-05 23.3 0.1 2.5 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.9 KOG96382.1 - 2e-05 24.2 0.1 7.5e-05 22.4 0.0 2.0 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 KOG96382.1 - 3.6e-05 23.6 0.0 0.00011 22.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOG96382.1 - 0.0006 20.6 0.0 0.0012 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain SRPRB PF09439.5 KOG96382.1 - 0.0014 17.8 8.1 1.5 7.9 0.0 4.3 4 1 0 4 4 4 2 Signal recognition particle receptor beta subunit AAA_22 PF13401.1 KOG96382.1 - 0.0033 17.5 0.1 0.02 15.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOG96382.1 - 0.0036 16.4 0.1 0.018 14.1 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin AAA_10 PF12846.2 KOG96382.1 - 0.0039 16.6 0.2 0.0067 15.9 0.1 1.4 1 0 0 1 1 1 1 AAA-like domain AAA_18 PF13238.1 KOG96382.1 - 0.01 16.1 0.0 0.041 14.1 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KOG96382.1 - 0.012 15.5 0.3 0.77 9.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain ArgK PF03308.11 KOG96382.1 - 0.017 13.9 3.2 0.023 13.5 0.0 2.7 3 1 0 3 3 3 0 ArgK protein APS_kinase PF01583.15 KOG96382.1 - 0.017 14.7 0.0 0.044 13.4 0.0 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase MipZ PF09140.6 KOG96382.1 - 0.018 14.1 0.8 0.21 10.6 0.1 2.5 2 1 0 2 2 2 0 ATPase MipZ VirE PF05272.6 KOG96382.1 - 0.037 13.5 0.0 0.083 12.3 0.0 1.6 1 0 0 1 1 1 0 Virulence-associated protein E AAA_16 PF13191.1 KOG96382.1 - 0.076 12.9 0.0 0.21 11.5 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.1 KOG96382.1 - 0.091 12.1 0.0 0.27 10.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.1 KOG96382.1 - 0.12 12.6 4.4 0.052 13.8 0.7 2.1 1 1 1 2 2 2 0 AAA domain AAA PF00004.24 KOG96382.1 - 1.7 8.8 6.8 1 9.5 0.8 3.2 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) DIL PF01843.14 KOG96383.1 - 2.9e-07 30.3 11.1 0.00033 20.4 0.2 3.2 3 1 1 4 4 4 2 DIL domain FRD2 PF03197.8 KOG96383.1 - 0.017 15.6 0.2 0.048 14.2 0.2 1.7 1 0 0 1 1 1 0 Bacteriophage FRD2 protein BUD22 PF09073.5 KOG96383.1 - 3.6 6.5 22.8 0.16 10.9 4.8 2.3 2 0 0 2 2 2 0 BUD22 DUF2404 PF10296.4 KOG96384.1 - 7.2e-31 106.1 0.0 1.4e-30 105.2 0.0 1.5 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) PH PF00169.24 KOG96384.1 - 1.3e-14 54.1 0.5 1.3e-14 54.1 0.3 2.4 3 0 0 3 3 3 1 PH domain PH_11 PF15413.1 KOG96384.1 - 1.9e-05 24.8 3.3 8.6e-05 22.7 0.0 3.2 2 1 1 3 3 3 1 Pleckstrin homology domain zf-RING_2 PF13639.1 KOG96385.1 - 6.5e-10 38.6 24.6 4.1e-09 36.1 5.5 2.4 2 0 0 2 2 2 2 Ring finger domain zf-rbx1 PF12678.2 KOG96385.1 - 3e-05 24.0 5.7 3e-05 24.0 3.9 3.0 2 1 0 2 2 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 KOG96385.1 - 3.4e-05 23.4 6.6 3.4e-05 23.4 4.5 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOG96385.1 - 0.0001 21.8 5.3 0.0001 21.8 3.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.24 KOG96385.1 - 0.0001 21.8 25.6 0.0058 16.2 7.6 2.7 2 1 0 2 2 2 2 PHD-finger zf-RING_5 PF14634.1 KOG96385.1 - 0.00051 19.7 6.6 0.00051 19.7 4.6 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 KOG96385.1 - 0.001 18.8 3.8 0.001 18.8 2.7 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-HC5HC2H_2 PF13832.1 KOG96385.1 - 0.0097 15.8 14.0 0.16 11.9 2.6 2.6 2 1 0 2 2 2 2 PHD-zinc-finger like domain zf-C3HC4_2 PF13923.1 KOG96385.1 - 0.015 15.3 8.1 0.015 15.3 5.6 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOG96385.1 - 0.07 12.8 2.6 0.1 12.3 0.8 2.2 1 1 0 1 1 1 0 RING-type zinc-finger zf-HC5HC2H PF13771.1 KOG96385.1 - 0.073 13.2 16.0 0.14 12.3 2.8 3.0 2 1 1 3 3 3 0 PHD-like zinc-binding domain Ribosomal_60s PF00428.14 KOG96385.1 - 0.2 12.0 5.6 0.34 11.3 3.8 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Baculo_IE-1 PF05290.6 KOG96385.1 - 0.71 9.5 9.0 2.7 7.7 1.3 2.4 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) FANCL_C PF11793.3 KOG96385.1 - 3.2 7.7 22.7 0.6 10.1 5.6 3.1 2 1 1 3 3 3 0 FANCL C-terminal domain PHF5 PF03660.9 KOG96386.1 - 2.1e-50 169.2 12.8 2.3e-50 169.1 8.9 1.0 1 0 0 1 1 1 1 PHF5-like protein Prok-RING_1 PF14446.1 KOG96386.1 - 3.1 7.6 18.2 4.8 7.0 5.3 2.7 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 Sec7 PF01369.15 KOG96387.1 - 2e-34 118.9 2.8 4.5e-34 117.7 1.9 1.6 1 0 0 1 1 1 1 Sec7 domain DUF3818 PF12825.2 KOG96388.1 - 1.1e-132 441.8 9.1 1.1e-132 441.8 6.3 2.5 3 0 0 3 3 3 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.2 KOG96388.1 - 1.5e-46 157.4 1.8 4.8e-46 155.7 1.3 2.0 1 0 0 1 1 1 1 PX-associated PX PF00787.19 KOG96388.1 - 1.1e-08 34.8 9.5 2.1e-08 33.9 4.4 2.9 2 1 0 2 2 2 1 PX domain DUF4149 PF13664.1 KOG96389.1 - 1.6e-20 73.0 3.5 1.6e-20 73.0 2.4 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4149) L51_S25_CI-B8 PF05047.11 KOG96390.1 - 3.6e-14 52.2 0.0 6.1e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain KID PF02524.9 KOG96390.1 - 0.46 10.7 4.0 12 6.5 0.5 2.8 2 0 0 2 2 2 0 KID repeat Ribosomal_L5_C PF00673.16 KOG96391.1 - 8.4e-23 79.9 0.0 1.3e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 KOG96391.1 - 7.7e-21 73.6 0.2 2.1e-20 72.2 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L5 Proteasome PF00227.21 KOG96392.1 - 2.4e-49 167.2 0.1 2.9e-49 166.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Fork_head PF00250.13 KOG96393.1 - 2.3e-34 117.3 0.5 5.5e-34 116.0 0.3 1.6 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 KOG96393.1 - 1.8e-11 43.9 0.3 3.6e-11 43.0 0.2 1.5 1 0 0 1 1 1 1 FHA domain COG4 PF08318.7 KOG96394.1 - 1.8e-117 391.8 6.0 1.8e-117 391.8 4.2 2.4 3 0 0 3 3 3 1 COG4 transport protein Staphostatin_A PF09022.5 KOG96394.1 - 0.0031 17.3 4.0 0.12 12.2 0.2 3.0 2 1 0 2 2 2 2 Staphostatin A Pkinase PF00069.20 KOG96395.1 - 1e-21 77.3 0.0 1.5e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96395.1 - 2.2e-09 36.7 0.0 4.2e-09 35.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG96395.1 - 3.4e-08 32.8 0.0 5.7e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 KOG96395.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 KOG96395.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-CCCH PF00642.19 KOG96396.1 - 8.8e-15 53.9 26.9 0.0002 20.9 0.2 5.5 4 2 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RPN7 PF10602.4 KOG96397.1 - 5.7e-52 175.6 4.7 5.7e-52 175.6 3.2 1.6 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.22 KOG96397.1 - 6.2e-15 55.4 0.1 2.6e-14 53.4 0.0 2.1 2 0 0 2 2 2 1 PCI domain TPR_8 PF13181.1 KOG96397.1 - 5.9e-05 22.5 0.7 0.00022 20.7 0.5 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOG96397.1 - 0.0003 20.6 2.5 0.0046 16.8 0.3 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOG96397.1 - 0.00075 19.2 1.4 0.011 15.6 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.1 KOG96397.1 - 0.0049 15.9 0.1 0.0078 15.3 0.1 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOG96397.1 - 0.0087 15.7 0.0 0.43 10.4 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOG96397.1 - 0.013 15.1 2.4 0.013 15.1 0.3 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOG96397.1 - 0.017 15.7 0.0 1.5 9.7 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF357 PF04010.8 KOG96397.1 - 0.021 14.4 0.3 0.053 13.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF357) TPR_21 PF09976.4 KOG96397.1 - 0.034 14.1 0.3 0.087 12.7 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Ank_2 PF12796.2 KOG96397.1 - 0.05 13.9 0.0 0.13 12.5 0.0 1.8 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) TPR_19 PF14559.1 KOG96397.1 - 0.44 10.9 5.7 0.28 11.5 0.2 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1746 PF08508.5 KOG96398.1 - 4.7e-05 23.2 0.3 1.3 9.0 0.0 3.1 3 0 0 3 3 3 3 Fungal domain of unknown function (DUF1746) RNA_pol_A_bac PF01000.21 KOG96399.1 - 1.4e-29 102.5 0.0 2.9e-29 101.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 KOG96399.1 - 5e-15 54.3 0.0 6.6e-15 53.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Hormone_4 PF00220.12 KOG96399.1 - 1.1 9.0 3.0 21 5.1 0.3 2.7 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain Pkinase PF00069.20 KOG96400.1 - 2.3e-53 180.9 0.1 3.2e-52 177.2 0.1 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96400.1 - 2.3e-27 95.6 0.3 3e-19 69.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.19 KOG96400.1 - 1.5e-05 25.4 2.1 3.3e-05 24.3 1.4 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 KOG96400.1 - 0.0024 16.8 0.0 0.023 13.6 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOG96400.1 - 0.028 13.4 0.0 0.053 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG96400.1 - 0.077 12.7 0.0 0.28 10.8 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family RRM_1 PF00076.17 KOG96401.1 - 2e-69 229.1 11.1 5.4e-17 61.1 0.1 6.4 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG96401.1 - 1.7e-63 210.4 4.4 1.9e-15 56.5 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96401.1 - 3.3e-38 129.3 0.1 4.3e-09 36.0 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 KOG96401.1 - 0.00085 19.0 0.9 4.4 7.1 0.0 3.9 2 1 1 3 3 3 2 Limkain b1 Nup35_RRM_2 PF14605.1 KOG96401.1 - 0.0063 16.2 0.0 2.7 7.8 0.0 3.7 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif PFO_beta_C PF12367.3 KOG96401.1 - 0.084 12.8 1.3 8.1 6.4 0.1 3.9 4 0 0 4 4 4 0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal SVS_QK PF10578.4 KOG96401.1 - 2.5 8.6 4.4 5.1 7.7 0.1 3.2 3 0 0 3 3 3 0 Seminal vesicle protein repeat CDP-OH_P_transf PF01066.16 KOG96402.1 - 7e-19 68.0 3.8 1.4e-18 67.0 2.6 1.5 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase TRAM_LAG1_CLN8 PF03798.11 KOG96403.1 - 3.9e-31 108.1 18.4 3.9e-31 108.1 12.8 1.6 2 0 0 2 2 2 1 TLC domain PH PF00169.24 KOG96404.1 - 1.4e-11 44.4 16.3 1.2e-10 41.4 11.3 2.6 1 1 0 1 1 1 1 PH domain DUF1322 PF07032.6 KOG96405.1 - 0.048 13.8 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1322) Fmp27_WPPW PF10359.4 KOG96406.1 - 2.8e-132 441.4 2.4 3.3e-132 441.2 0.1 2.2 3 0 0 3 3 3 1 RNA pol II promoter Fmp27 protein domain Apt1 PF10351.4 KOG96406.1 - 2.3e-112 376.1 3.8 3.8e-112 375.4 0.3 2.7 3 0 0 3 3 3 1 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.4 KOG96406.1 - 2.3e-47 160.8 0.2 6.4e-47 159.3 0.1 1.9 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.4 KOG96406.1 - 1.5e-42 145.0 4.0 4.9e-42 143.3 2.8 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.4 KOG96406.1 - 4.5e-23 81.6 0.9 6.9e-22 77.8 0.0 3.6 3 0 0 3 3 3 1 RNA pol II promoter Fmp27 protein domain IF-2B PF01008.12 KOG96407.1 - 4.1e-90 301.5 0.0 4.8e-90 301.3 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Cyclin_N PF00134.18 KOG96408.1 - 4.1e-40 136.2 0.2 1.3e-39 134.6 0.1 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 KOG96408.1 - 1.4e-30 105.6 0.0 3.7e-30 104.2 0.0 1.8 1 0 0 1 1 1 1 Cyclin, C-terminal domain Zot PF05707.7 KOG96408.1 - 0.071 12.5 0.1 0.18 11.2 0.0 1.7 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) Cyclin_N PF00134.18 KOG96409.1 - 5.8e-40 135.7 0.4 2.7e-39 133.6 0.2 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 KOG96409.1 - 1.1e-18 67.2 0.1 3.4e-18 65.6 0.0 1.9 2 0 0 2 2 2 1 Cyclin, C-terminal domain Peptidase_M16 PF00675.15 KOG96410.1 - 1.1e-36 125.8 0.0 2.4e-36 124.7 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 KOG96410.1 - 4e-16 59.2 1.5 0.0006 19.5 0.0 4.6 4 2 0 4 4 4 3 Peptidase M16 inactive domain DUF2807 PF10988.3 KOG96410.1 - 0.065 12.7 2.5 0.16 11.4 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2807) Ctr PF04145.10 KOG96411.1 - 1.7e-30 106.0 2.1 1.7e-30 106.0 1.5 2.2 3 0 0 3 3 3 1 Ctr copper transporter family DUF4229 PF14012.1 KOG96411.1 - 0.0079 16.0 2.6 0.0079 16.0 1.8 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4229) LETM1 PF07766.8 KOG96412.1 - 4.4e-88 294.7 2.7 4.4e-88 294.7 1.9 1.4 2 0 0 2 2 2 1 LETM1-like protein GPAT_N PF14829.1 KOG96412.1 - 0.017 14.7 0.1 0.42 10.3 0.0 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate acyltransferase N-terminal RNA_pol_3_Rpc31 PF11705.3 KOG96412.1 - 1.4 8.8 10.1 3 7.7 0.2 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Aldo_ket_red PF00248.16 KOG96413.1 - 1.5e-51 174.9 0.0 1.7e-51 174.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Mito_carr PF00153.22 KOG96414.1 - 5.4e-52 173.4 4.1 5.2e-21 74.1 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein LSM14 PF12701.2 KOG96415.1 - 2e-24 85.2 0.1 4.7e-24 84.0 0.1 1.8 1 1 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.5 KOG96415.1 - 3.3e-13 50.0 15.9 3.3e-13 50.0 11.0 3.1 3 2 0 3 3 3 1 FDF domain SM-ATX PF14438.1 KOG96415.1 - 0.015 15.2 0.1 0.04 13.8 0.0 1.8 2 0 0 2 2 2 0 Ataxin 2 SM domain Acetyltransf_1 PF00583.19 KOG96416.1 - 2e-10 40.5 0.0 3.7e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 KOG96416.1 - 1.2e-05 25.0 0.0 2.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 KOG96416.1 - 0.0003 20.8 0.0 0.00054 20.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOG96416.1 - 0.0096 16.0 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 KOG96416.1 - 0.018 14.9 0.1 0.048 13.5 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Ribosom_S12_S23 PF00164.20 KOG96417.1 - 7.9e-41 138.3 0.5 9.3e-41 138.0 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Med26 PF08711.6 KOG96418.1 - 2.7e-14 52.3 0.0 5.9e-14 51.3 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Tom5 PF10642.4 KOG96419.1 - 4.3e-26 90.2 1.0 4.6e-26 90.2 0.7 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase DUF3526 PF12040.3 KOG96419.1 - 0.037 14.1 0.2 0.039 14.1 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3526) DUF3639 PF12341.3 KOG96421.1 - 5.7e-09 35.8 0.3 1.1e-08 34.8 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3639) WD40 PF00400.27 KOG96422.1 - 1.5e-23 81.7 2.7 1.3e-06 28.0 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat Ammonium_transp PF00909.16 KOG96423.1 - 8.4e-124 413.0 26.5 9.7e-124 412.8 18.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Colicin PF01024.14 KOG96423.1 - 0.56 9.7 1.8 0.82 9.2 0.1 2.1 2 0 0 2 2 2 0 Colicin pore forming domain Acyltransferase PF01553.16 KOG96425.1 - 1e-11 44.4 0.0 1.4e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Kinesin PF00225.18 KOG96426.1 - 2.4e-105 351.9 5.0 2.4e-105 351.9 3.5 2.1 2 1 1 3 3 3 1 Kinesin motor domain PolyA_pol PF01743.15 KOG96426.1 - 0.5 10.5 6.1 0.21 11.7 1.6 2.3 2 0 0 2 2 2 0 Poly A polymerase head domain Rrp15p PF07890.7 KOG96427.1 - 5.8e-31 107.2 14.1 5.8e-31 107.2 9.8 2.5 2 1 0 2 2 2 1 Rrp15p TRAP_alpha PF03896.11 KOG96427.1 - 0.9 8.4 11.1 1.9 7.3 7.7 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TEX19 PF15553.1 KOG96427.1 - 3.9 7.3 5.2 10 5.9 3.6 1.7 1 0 0 1 1 1 0 Testis-expressed protein 19 CBF PF03914.12 KOG96428.1 - 2e-45 154.2 0.6 4.5e-45 153.0 0.4 1.6 1 0 0 1 1 1 1 CBF/Mak21 family Asn_synthase PF00733.16 KOG96429.1 - 2.8e-70 236.7 0.0 3.7e-70 236.3 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 KOG96429.1 - 1.5e-33 115.2 0.0 2.4e-33 114.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 KOG96429.1 - 1.9e-27 95.8 0.0 1.2e-26 93.2 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.3 KOG96429.1 - 1.7e-06 27.4 0.0 2.9e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein GATase_2 PF00310.16 KOG96429.1 - 8.6e-06 24.6 0.0 0.048 12.3 0.0 2.9 1 1 2 3 3 3 2 Glutamine amidotransferases class-II NAD_synthase PF02540.12 KOG96429.1 - 0.02 13.8 0.0 0.03 13.2 0.0 1.4 1 1 0 1 1 1 0 NAD synthase RRS1 PF04939.7 KOG96430.1 - 0.045 13.2 1.2 0.051 13.0 0.9 1.1 1 0 0 1 1 1 0 Ribosome biogenesis regulatory protein (RRS1) DUF2305 PF10230.4 KOG96431.1 - 1.5e-72 244.2 4.4 1.7e-72 244.0 3.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_6 PF12697.2 KOG96431.1 - 2.5e-09 37.3 0.0 3.4e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOG96431.1 - 3.8e-05 23.4 0.0 4.4e-05 23.2 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF1057 PF06342.7 KOG96431.1 - 0.0023 16.8 7.9 0.054 12.3 0.9 2.1 1 1 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF1057) PGAP1 PF07819.8 KOG96431.1 - 0.004 16.7 0.5 0.004 16.7 0.4 1.8 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_3 PF07859.8 KOG96431.1 - 0.0061 16.1 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOG96431.1 - 0.012 14.8 0.1 0.024 13.8 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family Lipase_3 PF01764.20 KOG96431.1 - 0.014 15.0 0.1 0.026 14.1 0.1 1.5 1 0 0 1 1 1 0 Lipase (class 3) Ndr PF03096.9 KOG96431.1 - 0.018 13.5 0.1 0.029 12.8 0.0 1.4 1 0 0 1 1 1 0 Ndr family Thioesterase PF00975.15 KOG96431.1 - 0.025 14.8 0.0 0.034 14.3 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_1 PF00561.15 KOG96431.1 - 0.035 13.6 0.0 0.059 12.9 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF3089 PF11288.3 KOG96431.1 - 0.079 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) DUF1749 PF08538.5 KOG96431.1 - 0.27 10.0 2.7 0.14 11.0 0.2 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1749) BAR_2 PF10455.4 KOG96432.1 - 4.6e-105 350.6 43.7 8.3e-105 349.8 30.3 1.4 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking MARVEL PF01284.18 KOG96433.1 - 1.8e-27 95.9 12.7 2.2e-27 95.6 8.8 1.1 1 0 0 1 1 1 1 Membrane-associating domain Tetraspannin PF00335.15 KOG96433.1 - 0.14 11.4 11.4 0.31 10.2 0.7 2.1 1 1 1 2 2 2 0 Tetraspanin family Pet20 PF08692.5 KOG96434.1 - 4.5e-59 198.2 0.6 6.5e-59 197.7 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial protein Pet20 Tmemb_170 PF10190.4 KOG96435.1 - 0.00059 19.8 6.5 0.0007 19.6 4.5 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 DUF457 PF04307.9 KOG96435.1 - 5.3 6.3 7.8 18 4.5 5.2 2.0 1 1 0 1 1 1 0 Predicted membrane-bound metal-dependent hydrolase (DUF457) SH3_1 PF00018.23 KOG96436.1 - 1.5e-13 49.9 0.0 2.8e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOG96436.1 - 3e-12 45.9 0.1 4.5e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOG96436.1 - 1.9e-11 43.2 0.0 2.8e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain DUF2076 PF09849.4 KOG96436.1 - 0.0079 16.2 4.0 0.012 15.6 2.8 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) DUF605 PF04652.11 KOG96436.1 - 0.019 14.3 13.5 0.02 14.3 9.4 1.2 1 0 0 1 1 1 0 Vta1 like PAT1 PF09770.4 KOG96436.1 - 0.037 12.2 19.0 0.042 12.0 13.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pex14_N PF04695.8 KOG96436.1 - 0.072 13.1 8.9 0.14 12.1 6.2 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NCA2 PF08637.5 KOG96437.1 - 5.9e-108 360.1 5.2 5.9e-108 360.1 3.6 1.9 3 0 0 3 3 3 1 ATP synthase regulation protein NCA2 COG2 PF06148.6 KOG96437.1 - 1.1 9.0 6.4 4 7.3 2.9 2.9 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 MFS_1 PF07690.11 KOG96438.1 - 3.1e-32 111.6 32.7 3.1e-32 111.6 22.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOG96438.1 - 1.8e-12 46.6 22.6 4.6e-12 45.2 15.7 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter DUF946 PF06101.6 KOG96439.1 - 3.2e-05 22.1 2.2 0.00038 18.5 0.6 2.2 2 0 0 2 2 2 2 Plant protein of unknown function (DUF946) PseudoU_synth_1 PF01416.15 KOG96440.1 - 0.12 12.7 0.3 0.33 11.4 0.2 1.7 1 0 0 1 1 1 0 tRNA pseudouridine synthase SKN1 PF03935.10 KOG96441.1 - 5.6e-255 846.2 4.6 6.7e-255 845.9 3.2 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Phosphorylase PF00343.15 KOG96442.1 - 0 1031.1 0.7 0 1030.9 0.5 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Pkinase PF00069.20 KOG96443.1 - 1.2e-76 257.3 0.0 1.7e-76 256.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96443.1 - 1.7e-32 112.4 0.0 2.6e-32 111.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ORC4_C PF14629.1 KOG96444.1 - 7.3e-36 123.4 0.5 1.2e-35 122.7 0.4 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.1 KOG96444.1 - 4.3e-07 30.0 0.0 1e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain Ins_allergen_rp PF06757.8 KOG96444.1 - 0.017 14.6 0.2 0.55 9.7 0.0 2.9 2 1 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification AAA_14 PF13173.1 KOG96444.1 - 0.064 13.1 0.6 0.37 10.6 0.2 2.6 1 1 0 2 2 2 0 AAA domain RRM_6 PF14259.1 KOG96445.1 - 2.2e-10 40.3 0.0 5.8e-10 39.0 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOG96445.1 - 0.00067 19.2 0.0 0.0016 18.0 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96445.1 - 0.011 15.5 0.0 0.04 13.7 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2559 PF10832.3 KOG96445.1 - 1.1 9.1 14.8 42 4.0 0.0 5.8 4 1 2 6 6 6 0 Protein of unknown function (DUF2559) MMS1_N PF10433.4 KOG96446.1 - 7.8e-40 136.4 14.5 7.1e-39 133.2 8.1 3.1 2 1 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Ras PF00071.17 KOG96447.1 - 2.5e-55 186.2 0.0 3e-55 186.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG96447.1 - 5.5e-16 59.1 0.0 9.1e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOG96447.1 - 5.7e-07 28.9 0.0 8e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KOG96447.1 - 0.00052 19.4 0.0 0.0024 17.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KOG96447.1 - 0.016 14.3 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region LEA_5 PF00477.12 KOG96447.1 - 0.027 14.7 1.1 0.049 13.9 0.8 1.5 1 0 0 1 1 1 0 Small hydrophilic plant seed protein SRPRB PF09439.5 KOG96447.1 - 0.066 12.4 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Ribosomal_S14 PF00253.16 KOG96448.1 - 1.5e-16 59.4 1.1 1.6e-16 59.3 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e PAPS_reduct PF01507.14 KOG96449.1 - 1.3e-44 152.0 0.0 1.8e-44 151.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family BCL9 PF11502.3 KOG96449.1 - 0.033 13.7 0.4 0.065 12.7 0.3 1.4 1 0 0 1 1 1 0 B-cell lymphoma 9 protein Cadherin_C PF01049.12 KOG96449.1 - 0.07 13.1 0.1 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Cadherin cytoplasmic region Med10 PF09748.4 KOG96450.1 - 1.2e-45 154.4 0.1 2.1e-45 153.6 0.1 1.4 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF2203 PF09969.4 KOG96450.1 - 0.086 13.0 0.9 0.27 11.4 0.2 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) PBS_linker_poly PF00427.16 KOG96450.1 - 0.088 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide WD40 PF00400.27 KOG96451.1 - 0.023 14.5 2.9 0.28 11.1 0.1 3.8 5 0 0 5 5 5 0 WD domain, G-beta repeat CDC45 PF02724.9 KOG96451.1 - 0.69 7.8 14.7 1.1 7.1 10.2 1.3 1 0 0 1 1 1 0 CDC45-like protein GEMIN8 PF15348.1 KOG96451.1 - 2.1 8.3 14.3 14 5.6 7.3 2.2 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 DUF1767 PF08585.7 KOG96453.1 - 0.028 14.6 0.1 0.087 13.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1767) Pyridox_oxidase PF01243.15 KOG96454.1 - 3.4e-18 65.4 0.0 9.5e-18 63.9 0.0 1.7 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase DUF4574 PF15141.1 KOG96454.1 - 0.09 12.5 0.2 13 5.5 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4574) L_biotic_typeA PF04604.8 KOG96454.1 - 0.13 11.8 2.1 0.4 10.3 0.2 2.2 2 0 0 2 2 2 0 Type-A lantibiotic AAA PF00004.24 KOG96455.1 - 7.3e-44 149.1 0.0 1.3e-43 148.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 KOG96455.1 - 2.6e-30 104.1 0.2 1.7e-29 101.5 0.2 2.2 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.13 KOG96455.1 - 1.4e-23 82.5 3.9 1.1e-22 79.6 2.3 2.6 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain AAA_17 PF13207.1 KOG96455.1 - 5e-06 27.3 0.3 3.4e-05 24.6 0.0 2.5 2 1 0 2 2 1 1 AAA domain AAA_22 PF13401.1 KOG96455.1 - 7.4e-06 26.1 0.4 0.00079 19.5 0.1 2.9 2 1 0 2 2 1 1 AAA domain AAA_5 PF07728.9 KOG96455.1 - 9.1e-06 25.4 0.0 4.2e-05 23.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 KOG96455.1 - 1.4e-05 24.2 0.0 2.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 KOG96455.1 - 1.8e-05 24.2 0.0 4.1e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 KOG96455.1 - 1.8e-05 24.6 0.0 6.3e-05 22.8 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.1 KOG96455.1 - 6.3e-05 22.4 0.2 0.025 13.9 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 KOG96455.1 - 9.3e-05 22.4 0.1 0.00051 20.0 0.0 2.2 2 1 0 2 2 1 1 AAA ATPase domain TIP49 PF06068.8 KOG96455.1 - 0.00011 21.0 0.0 0.00018 20.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus DUF815 PF05673.8 KOG96455.1 - 0.00021 20.3 0.0 0.00045 19.2 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF815) RNA_helicase PF00910.17 KOG96455.1 - 0.00023 21.2 0.2 0.0079 16.3 0.0 2.8 3 0 0 3 3 2 1 RNA helicase AAA_2 PF07724.9 KOG96455.1 - 0.00042 20.2 0.0 0.0014 18.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 KOG96455.1 - 0.00053 19.8 0.0 0.0012 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOG96455.1 - 0.0091 15.1 0.1 0.22 10.6 0.0 2.3 1 1 1 2 2 2 1 Zeta toxin AAA_18 PF13238.1 KOG96455.1 - 0.0091 16.2 0.0 0.024 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 KOG96455.1 - 0.013 15.1 0.0 0.024 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Torsin PF06309.6 KOG96455.1 - 0.015 15.2 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 Torsin Arch_ATPase PF01637.13 KOG96455.1 - 0.017 14.7 0.1 0.58 9.8 0.0 2.5 1 1 1 2 2 2 0 Archaeal ATPase Mg_chelatase PF01078.16 KOG96455.1 - 0.028 13.5 0.0 0.062 12.4 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI KaiC PF06745.8 KOG96455.1 - 0.029 13.4 0.1 4.7 6.2 0.0 2.2 1 1 1 2 2 2 0 KaiC PhoH PF02562.11 KOG96455.1 - 0.033 13.4 0.0 0.076 12.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein ResIII PF04851.10 KOG96455.1 - 0.034 13.9 0.1 0.089 12.6 0.0 1.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_19 PF13245.1 KOG96455.1 - 0.034 13.8 0.0 0.099 12.4 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain NACHT PF05729.7 KOG96455.1 - 0.066 12.8 0.0 0.69 9.5 0.0 2.1 1 1 1 2 2 2 0 NACHT domain Sigma54_activat PF00158.21 KOG96455.1 - 0.076 12.4 0.0 0.22 10.9 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Parvo_NS1 PF01057.12 KOG96455.1 - 0.077 11.8 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CPT PF07931.7 KOG96455.1 - 0.1 12.2 0.0 0.35 10.4 0.0 1.8 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_21 PF13304.1 KOG96455.1 - 0.1 12.5 0.2 3.2 7.6 0.0 2.4 1 1 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.1 KOG96455.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.1 KOG96455.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.7 2 0 0 2 2 1 0 AAA domain Use1 PF09753.4 KOG96455.1 - 0.15 11.5 0.3 0.27 10.6 0.2 1.4 1 0 0 1 1 1 0 Membrane fusion protein Use1 NBP1 PF08537.5 KOG96456.1 - 3.5e-57 194.0 20.7 1.7e-55 188.5 5.1 2.0 1 1 1 2 2 2 2 Fungal Nap binding protein NBP1 DNA_pol_E_B PF04042.11 KOG96457.1 - 1.7e-56 190.7 2.2 2.4e-56 190.3 0.9 1.7 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B gp32 PF08804.5 KOG96457.1 - 0.027 14.5 0.2 0.74 9.9 0.0 3.3 4 0 0 4 4 4 0 gp32 DNA binding protein like Prenyltrans PF00432.16 KOG96458.1 - 5.6e-64 211.3 2.9 7.9e-13 47.7 0.0 6.0 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 KOG96458.1 - 5.7e-24 84.6 0.0 2.9e-11 43.7 0.0 3.7 1 1 3 4 4 4 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 KOG96458.1 - 6e-06 26.2 0.0 2.1e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 Prenyltransferase-like WD40 PF00400.27 KOG96459.1 - 1.9e-55 182.8 17.6 5.3e-11 41.9 0.4 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 KOG96459.1 - 0.0004 20.1 0.1 0.031 13.9 0.0 3.2 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A HDA2-3 PF11496.3 KOG96460.1 - 5.5e-90 301.1 0.5 1.1e-89 300.1 0.3 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ThiF PF00899.16 KOG96461.1 - 1.1e-20 73.7 0.0 2e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 ThiF family Sec23_trunk PF04811.10 KOG96462.1 - 2.1e-74 249.9 0.0 2.9e-74 249.4 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 KOG96462.1 - 1.5e-35 120.6 0.1 3.2e-35 119.6 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 KOG96462.1 - 1.9e-29 101.9 0.0 3.9e-29 100.9 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 KOG96462.1 - 1.1e-14 53.6 9.1 1.9e-14 52.8 6.3 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 KOG96462.1 - 6.9e-12 44.8 0.0 1.7e-11 43.5 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat LSM PF01423.17 KOG96463.1 - 3.3e-17 61.7 0.3 3.9e-17 61.5 0.2 1.1 1 0 0 1 1 1 1 LSM domain Glycos_transf_2 PF00535.21 KOG96464.1 - 2.8e-27 95.4 0.0 4.4e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KOG96464.1 - 1.5e-08 34.7 0.0 2.3e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 KOG96464.1 - 1.3e-06 27.7 0.0 1.8e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 hDGE_amylase PF14701.1 KOG96465.1 - 4.7e-170 566.0 0.1 7.3e-170 565.4 0.1 1.3 1 0 0 1 1 1 1 glucanotransferase domain of human glycogen debranching enzyme GDE_C PF06202.9 KOG96465.1 - 2.1e-131 438.0 0.0 3.2e-131 437.4 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.1 KOG96465.1 - 2.4e-72 243.2 0.0 3.7e-72 242.6 0.0 1.3 1 0 0 1 1 1 1 central domain of human glycogen debranching enzyme hGDE_N PF14699.1 KOG96465.1 - 1e-20 73.3 0.0 3.1e-20 71.8 0.0 1.9 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.19 KOG96465.1 - 5.7e-07 29.2 0.0 0.0015 17.9 0.1 2.4 2 0 0 2 2 2 2 Alpha amylase, catalytic domain ATG13 PF10033.4 KOG96466.1 - 1.1e-64 218.1 0.2 1.1e-64 218.1 0.2 1.8 2 0 0 2 2 2 1 Autophagy-related protein 13 RP-C_C PF11800.3 KOG96466.1 - 0.23 11.1 5.4 0.59 9.8 3.8 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region SpoVR PF04293.8 KOG96466.1 - 0.42 8.9 8.8 0.74 8.1 6.1 1.3 1 0 0 1 1 1 0 SpoVR like protein zf-C2H2 PF00096.21 KOG96467.1 - 2.7e-26 90.2 71.2 0.00016 21.7 1.9 9.3 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG96467.1 - 6.3e-23 79.3 64.4 0.00025 21.1 1.9 9.3 9 0 0 9 9 9 8 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KOG96467.1 - 8.1e-14 51.1 67.4 0.00048 20.2 0.8 10.3 11 0 0 11 11 10 7 Zinc-finger double domain zf-met PF12874.2 KOG96467.1 - 1.9e-09 37.3 30.9 0.025 14.7 1.8 8.2 8 0 0 8 8 8 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KOG96467.1 - 1.6e-05 24.9 54.9 0.033 14.3 0.1 9.4 10 0 0 10 10 9 4 Zinc-finger double-stranded RNA-binding CpXC PF14353.1 KOG96467.1 - 0.0032 17.4 4.2 0.0032 17.4 2.9 4.4 3 2 2 5 5 5 1 CpXC protein zf-Di19 PF05605.7 KOG96467.1 - 0.0048 16.9 41.2 0.54 10.4 4.3 5.9 2 1 2 5 5 5 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.2 KOG96467.1 - 0.02 15.0 41.5 0.45 10.6 1.3 6.0 2 1 3 5 5 5 0 C2H2 type zinc-finger (2 copies) Chibby PF14645.1 KOG96467.1 - 0.023 14.5 1.0 0.055 13.3 0.7 1.5 1 0 0 1 1 1 0 Chibby family BBP1_N PF15271.1 KOG96467.1 - 0.32 11.3 7.3 0.14 12.5 2.1 2.6 3 1 0 3 3 3 0 Spindle pole body component BBP1, Mps2-binding protein zf-4CXXC_R1 PF10497.4 KOG96467.1 - 5.7 7.1 19.5 1.4 9.1 1.1 3.5 2 1 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 RNA_pol_Rpb6 PF01192.17 KOG96468.1 - 3.1e-23 81.2 0.3 4.7e-23 80.6 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 EF-hand_7 PF13499.1 KOG96469.1 - 1e-05 25.5 0.7 0.00027 21.0 0.5 2.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOG96469.1 - 3.8e-05 23.2 2.1 0.00011 21.7 0.1 2.7 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.27 KOG96469.1 - 5.7e-05 22.1 0.4 5.7e-05 22.1 0.3 2.6 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOG96469.1 - 8.5e-05 21.7 0.5 8.5e-05 21.7 0.3 2.8 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.1 KOG96469.1 - 0.001 18.6 1.7 0.097 12.3 0.0 2.4 2 1 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOG96469.1 - 0.036 14.1 1.2 0.061 13.3 0.2 1.9 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Sigma_reg_C PF13791.1 KOG96469.1 - 0.08 12.9 0.7 0.23 11.5 0.5 1.8 1 1 0 1 1 1 0 Sigma factor regulator C-terminal IF2_N PF04760.10 KOG96469.1 - 0.11 12.1 2.1 2 8.1 0.0 3.5 4 1 0 4 4 4 0 Translation initiation factor IF-2, N-terminal region TPR_11 PF13414.1 KOG96470.1 - 3.6e-35 119.4 4.9 2.8e-06 26.8 0.0 10.8 8 4 5 13 13 13 9 TPR repeat TPR_16 PF13432.1 KOG96470.1 - 4.9e-20 71.6 0.0 0.039 14.6 0.0 8.7 6 2 2 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOG96470.1 - 1.1e-18 67.2 10.3 2.2e-05 24.6 0.0 9.0 9 2 2 11 11 11 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOG96470.1 - 1.4e-18 65.2 1.2 0.0041 16.9 0.0 11.7 12 0 0 12 12 11 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOG96470.1 - 1.4e-18 65.6 0.1 0.056 14.0 0.0 10.8 8 3 4 12 12 11 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOG96470.1 - 1.5e-15 56.0 10.9 0.00051 19.5 0.0 11.3 13 0 0 13 13 13 4 Tetratricopeptide repeat TPR_17 PF13431.1 KOG96470.1 - 2.9e-15 55.1 2.7 0.0049 16.9 0.0 9.6 11 0 0 11 11 9 2 Tetratricopeptide repeat Apc3 PF12895.2 KOG96470.1 - 2e-10 40.6 11.4 6.3e-05 23.0 0.0 7.5 8 0 0 8 8 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 KOG96470.1 - 6.4e-10 38.8 5.7 0.013 15.4 0.1 7.6 6 3 1 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOG96470.1 - 1.6e-08 33.7 9.2 0.035 13.8 0.0 9.5 11 1 1 12 12 9 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOG96470.1 - 7.8e-08 32.0 0.0 0.1 12.4 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOG96470.1 - 6.6e-07 29.3 2.9 12 6.5 0.0 8.4 10 0 0 10 10 8 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 KOG96470.1 - 0.0008 19.6 0.1 5.2 7.2 0.0 4.3 4 0 0 4 4 4 1 Alkyl sulfatase dimerisation TPR_7 PF13176.1 KOG96470.1 - 0.0013 18.3 1.5 1.7 8.6 0.0 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_20 PF14561.1 KOG96470.1 - 0.0014 18.7 0.1 0.72 10.0 0.0 4.4 4 2 1 5 5 3 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.5 KOG96470.1 - 0.017 14.6 0.0 0.31 10.5 0.0 2.6 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) RNA_pol_Rpc82 PF05645.8 KOG96471.1 - 3.6e-68 229.9 0.3 6.7e-68 229.0 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.6 KOG96471.1 - 7.6e-23 80.1 10.0 6.6e-19 67.5 0.1 3.9 4 0 0 4 4 4 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.12 KOG96471.1 - 0.00039 19.8 1.8 0.043 13.3 0.1 2.8 2 0 0 2 2 2 2 TFIIE alpha subunit Peptidase_M16 PF00675.15 KOG96472.1 - 1.5e-31 109.1 0.0 2.3e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 KOG96472.1 - 4.6e-06 26.4 0.1 2.4e-05 24.0 0.0 2.1 2 1 0 2 2 2 1 Peptidase M16 inactive domain MIP PF00230.15 KOG96473.1 - 3.8e-44 150.8 15.4 4.7e-44 150.5 10.7 1.1 1 0 0 1 1 1 1 Major intrinsic protein Acetyltransf_1 PF00583.19 KOG96474.1 - 1.3e-14 54.0 0.0 1.9e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 KOG96474.1 - 6.4e-07 29.4 0.0 7.8e-07 29.1 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KOG96474.1 - 1.6e-06 28.1 0.1 3.4e-06 27.1 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KOG96474.1 - 6.5e-06 26.3 0.0 8e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOG96474.1 - 1.6e-05 25.0 0.0 2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOG96474.1 - 0.00016 21.3 0.0 0.00023 20.8 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.1 KOG96474.1 - 0.0016 18.3 0.0 0.0018 18.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 KOG96474.1 - 0.0021 17.8 0.0 0.0038 17.0 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 KOG96474.1 - 0.039 13.5 0.0 0.08 12.5 0.0 1.5 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 KOG96474.1 - 0.041 13.7 0.0 0.072 12.9 0.0 1.4 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase Phage_30_8 PF06019.6 KOG96474.1 - 0.053 13.2 0.1 0.069 12.8 0.1 1.2 1 0 0 1 1 1 0 Phage GP30.8 protein OPT PF03169.10 KOG96475.1 - 1.5e-176 588.4 50.0 1.8e-176 588.2 34.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein His_Phos_2 PF00328.17 KOG96476.1 - 4.7e-51 174.1 0.4 5.9e-51 173.8 0.3 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) His_Phos_1 PF00300.17 KOG96476.1 - 0.0081 16.2 0.0 0.032 14.3 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PhyH PF05721.8 KOG96477.1 - 1.4e-34 120.0 0.3 1.7e-34 119.6 0.2 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.1 KOG96477.1 - 0.016 15.4 0.4 0.049 13.9 0.3 1.9 1 1 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase ADH_zinc_N PF00107.21 KOG96478.1 - 9.5e-15 54.2 0.0 1.5e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOG96478.1 - 0.00058 19.6 0.2 0.006 16.3 0.1 2.3 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain HRXXH PF13933.1 KOG96479.1 - 8.8e-84 280.7 0.7 1.1e-83 280.5 0.5 1.0 1 0 0 1 1 1 1 Putative peptidase family Aspzincin_M35 PF14521.1 KOG96479.1 - 0.0047 17.4 0.0 0.009 16.5 0.0 1.5 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase DJ-1_PfpI PF01965.19 KOG96480.1 - 1.7e-28 98.9 0.2 2.7e-28 98.2 0.2 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family DJ-1_PfpI_N PF13587.1 KOG96480.1 - 0.00015 21.2 0.0 0.0003 20.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of DJ-1_PfpI family MFS_1 PF07690.11 KOG96481.1 - 1.3e-08 34.0 42.6 6.1e-08 31.7 28.2 3.0 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 KOG96481.1 - 2.9e-05 22.5 19.3 2.9e-05 22.5 13.4 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 KOG96481.1 - 0.0012 17.4 9.8 0.0012 17.4 6.8 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter DUF507 PF04368.8 KOG96482.1 - 0.00085 19.0 1.2 0.0019 17.8 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF507) AA_permease_2 PF13520.1 KOG96484.1 - 8e-61 205.8 44.3 1.1e-60 205.3 30.5 1.4 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOG96484.1 - 1.3e-12 46.8 40.1 1.8e-12 46.4 27.8 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3366 PF11846.3 KOG96484.1 - 2.5 7.9 5.8 3.1 7.6 0.3 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF3366) ABC_tran PF00005.22 KOG96485.1 - 1.4e-56 190.5 0.2 8.6e-33 113.5 0.1 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 KOG96485.1 - 7.5e-45 153.4 39.2 9.7e-26 90.7 8.1 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_29 PF13555.1 KOG96485.1 - 1.8e-08 33.7 0.9 0.00023 20.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 KOG96485.1 - 6.2e-05 22.9 0.1 0.016 15.1 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF87 PF01935.12 KOG96485.1 - 9.3e-05 22.3 2.6 0.29 10.8 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function DUF87 DUF258 PF03193.11 KOG96485.1 - 0.0001 21.5 0.1 0.11 11.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 SMC_N PF02463.14 KOG96485.1 - 0.00013 21.2 7.5 0.0053 16.0 0.4 3.9 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KOG96485.1 - 0.00018 21.9 15.3 0.0035 17.6 0.2 3.6 3 1 0 3 3 2 2 AAA domain FtsK_SpoIIIE PF01580.13 KOG96485.1 - 0.00021 20.8 0.3 0.39 10.1 0.1 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family Miro PF08477.8 KOG96485.1 - 0.00064 20.2 1.4 0.2 12.1 0.0 2.8 2 0 0 2 2 2 1 Miro-like protein AAA_16 PF13191.1 KOG96485.1 - 0.0015 18.5 1.9 0.13 12.2 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 KOG96485.1 - 0.002 18.9 0.1 0.11 13.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 KOG96485.1 - 0.0062 15.4 0.2 2.2 7.1 0.1 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein Zeta_toxin PF06414.7 KOG96485.1 - 0.0074 15.4 0.0 1 8.4 0.0 2.8 3 0 0 3 3 3 1 Zeta toxin AAA_22 PF13401.1 KOG96485.1 - 0.0099 16.0 1.0 1.3 9.2 0.1 3.3 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.1 KOG96485.1 - 0.012 15.0 0.7 3.9 6.8 0.1 2.4 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 KOG96485.1 - 0.084 12.5 0.4 2.1 8.0 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 KOG96485.1 - 0.088 12.2 2.2 3 7.1 0.0 3.2 4 0 0 4 4 4 0 AAA-like domain Dynamin_N PF00350.18 KOG96485.1 - 0.096 12.5 3.0 9.1 6.0 0.5 3.0 3 0 0 3 3 3 0 Dynamin family AAA_33 PF13671.1 KOG96485.1 - 0.15 11.9 0.0 26 4.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 KOG96485.1 - 0.39 10.2 0.2 3.1 7.3 0.0 2.3 3 0 0 3 3 3 0 AAA domain RRM_1 PF00076.17 KOG96486.1 - 1.9e-19 69.0 5.5 7e-13 48.0 0.1 3.4 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG96486.1 - 2.5e-11 43.4 1.3 1.3e-05 25.0 0.1 2.6 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96486.1 - 0.0078 16.0 0.0 0.89 9.4 0.0 2.7 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L7Ae PF01248.21 KOG96487.1 - 1.9e-22 78.5 0.3 3e-22 77.9 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 KOG96487.1 - 0.00061 19.6 0.1 0.0011 18.8 0.1 1.4 1 0 0 1 1 1 1 RNase P subunit Pop3 V-SNARE_C PF12352.3 KOG96488.1 - 4.4e-20 71.5 3.5 4.4e-20 71.5 2.4 2.2 2 1 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus BLOC1_2 PF10046.4 KOG96488.1 - 0.0062 16.6 6.0 1.6 8.9 0.1 3.0 3 0 0 3 3 3 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sec34 PF04136.10 KOG96488.1 - 0.02 14.5 1.3 0.02 14.5 0.9 2.4 1 1 2 3 3 3 0 Sec34-like family ERp29 PF07749.7 KOG96488.1 - 0.041 14.4 0.9 2.8 8.6 0.0 3.1 1 1 1 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain RseA_N PF03872.8 KOG96488.1 - 0.051 13.8 0.5 0.09 13.0 0.3 1.6 1 1 0 1 1 1 0 Anti sigma-E protein RseA, N-terminal domain DUF4125 PF13526.1 KOG96488.1 - 0.18 11.3 1.6 0.29 10.6 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4125) WXG100 PF06013.7 KOG96488.1 - 0.75 9.8 5.8 8 6.5 0.0 3.3 2 1 2 4 4 4 0 Proteins of 100 residues with WXG Sec20 PF03908.8 KOG96488.1 - 0.86 9.3 8.8 0.1 12.2 0.4 2.8 2 1 1 3 3 3 0 Sec20 Peptidase_C6 PF00851.13 KOG96488.1 - 1 7.8 6.7 0.46 9.0 0.8 2.0 1 1 1 2 2 2 0 Helper component proteinase IncA PF04156.9 KOG96488.1 - 4.3 6.8 11.5 0.59 9.7 1.6 2.5 1 1 2 3 3 3 0 IncA protein Ecm29 PF13001.2 KOG96489.1 - 5.7e-125 417.6 8.3 5.7e-125 417.6 5.8 2.2 2 0 0 2 2 2 1 Proteasome stabiliser HEAT PF02985.17 KOG96489.1 - 7e-16 56.8 8.6 0.0008 19.2 0.0 8.4 9 0 0 9 9 9 3 HEAT repeat HEAT_EZ PF13513.1 KOG96489.1 - 4.8e-07 30.0 0.6 13 6.4 0.0 7.5 7 0 0 7 7 7 2 HEAT-like repeat Vac14_Fab1_bd PF12755.2 KOG96489.1 - 7.6e-05 23.0 3.8 0.065 13.6 0.0 6.3 6 2 2 8 8 8 1 Vacuolar 14 Fab1-binding region WSC PF01822.14 KOG96491.1 - 1.6e-05 24.6 16.5 1.6e-05 24.6 11.4 3.4 2 1 0 2 2 2 1 WSC domain Rifin_STEVOR PF02009.11 KOG96491.1 - 0.0042 16.7 2.0 0.0042 16.7 1.4 2.7 1 1 1 2 2 2 1 Rifin/stevor family PspB PF06667.7 KOG96491.1 - 0.0067 16.3 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Phage shock protein B DUF912 PF06024.7 KOG96491.1 - 0.7 9.9 0.0 0.7 9.9 0.0 3.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) zf-C2H2 PF00096.21 KOG96492.1 - 1.1e-05 25.4 22.2 0.00021 21.4 1.4 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-met PF12874.2 KOG96492.1 - 0.0026 17.8 5.0 0.031 14.4 0.2 3.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KOG96492.1 - 0.014 15.5 0.7 0.081 13.1 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 KOG96492.1 - 0.016 15.4 2.7 0.016 15.4 1.9 3.1 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOG96492.1 - 0.1 12.9 0.4 0.1 12.9 0.3 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger DUF2456 PF10445.4 KOG96493.1 - 3.8e-35 119.6 2.6 9.7e-35 118.3 1.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2456) Paf1 PF03985.8 KOG96494.1 - 0.66 8.6 11.0 1.2 7.7 7.6 1.4 1 0 0 1 1 1 0 Paf1 DUF3449 PF11931.3 KOG96494.1 - 0.77 9.2 7.1 1.4 8.4 4.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) DUF2115 PF09888.4 KOG96494.1 - 0.77 9.8 3.1 0.66 10.0 0.8 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) Hid1 PF12722.2 KOG96494.1 - 1.2 6.7 6.4 1.7 6.1 4.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ndc1_Nup PF09531.5 KOG96494.1 - 1.9 6.7 4.8 2.8 6.2 3.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FimP PF09766.4 KOG96494.1 - 2.7 6.9 13.7 4.3 6.2 9.5 1.3 1 0 0 1 1 1 0 Fms-interacting protein RRM_1 PF00076.17 KOG96495.1 - 4.1e-27 93.5 1.5 5e-14 51.6 0.1 4.0 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96495.1 - 3.6e-21 74.7 0.1 1.8e-07 30.8 0.0 3.8 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG96495.1 - 3.7e-15 55.6 0.6 8.7e-07 28.8 0.0 3.6 4 0 0 4 4 4 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KOG96495.1 - 7.5e-05 22.5 0.2 0.013 15.3 0.1 2.5 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.1 KOG96495.1 - 0.0049 16.5 0.2 0.91 9.3 0.0 3.0 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif DUF386 PF04074.7 KOG96495.1 - 0.049 13.1 0.3 0.11 12.0 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF386) NPR3 PF03666.8 KOG96496.1 - 3.8e-153 510.2 4.8 3.8e-153 510.2 3.3 2.6 3 1 0 3 3 3 1 Nitrogen Permease regulator of amino acid transport activity 3 TP6A_N PF04406.9 KOG96497.1 - 5.4e-15 54.8 0.2 1.6e-14 53.3 0.1 1.8 2 0 0 2 2 2 1 Type IIB DNA topoisomerase DUF2399 PF09664.5 KOG96497.1 - 0.022 14.6 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2399) MitMem_reg PF13012.1 KOG96497.1 - 0.05 13.6 0.3 0.13 12.3 0.2 1.7 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function TauD PF02668.11 KOG96498.1 - 1.9e-40 139.1 0.0 3.1e-40 138.4 0.0 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Vps51 PF08700.6 KOG96498.1 - 0.12 12.2 2.7 2.6 7.9 0.1 2.4 2 0 0 2 2 2 0 Vps51/Vps67 Opi1 PF08618.5 KOG96499.1 - 3.1e-36 125.2 2.0 4.6e-36 124.6 1.4 1.2 1 0 0 1 1 1 1 Transcription factor Opi1 Sigma70_ner PF04546.8 KOG96499.1 - 5.1 6.6 23.9 0.069 12.7 1.9 3.3 2 1 1 3 3 3 0 Sigma-70, non-essential region Adap_comp_sub PF00928.16 KOG96500.1 - 6.1e-69 232.0 1.6 6.1e-69 232.0 1.1 1.9 2 0 0 2 2 2 1 Adaptor complexes medium subunit family SR-25 PF10500.4 KOG96500.1 - 0.062 12.7 16.7 0.12 11.8 11.6 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pterin_4a PF01329.14 KOG96501.1 - 2.6e-24 84.7 0.2 3.1e-24 84.5 0.1 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Chor_lyase PF04345.8 KOG96501.1 - 0.097 12.1 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Chorismate lyase Lung_7-TM_R PF06814.8 KOG96502.1 - 1.4e-87 293.3 29.1 1.7e-87 293.1 20.2 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor DUF2681 PF10883.3 KOG96502.1 - 0.58 10.3 3.7 5.5 7.2 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF998 PF06197.8 KOG96502.1 - 3.1 7.0 14.1 0.41 9.9 5.3 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF998) SSF PF00474.12 KOG96503.1 - 1.1e-16 60.4 27.5 1.7e-16 59.8 19.0 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family DUF2207 PF09972.4 KOG96503.1 - 0.059 11.9 0.0 0.059 11.9 0.0 4.0 4 1 1 5 5 5 0 Predicted membrane protein (DUF2207) Ribosomal_S10 PF00338.17 KOG96504.1 - 2.1e-27 94.7 1.5 2.6e-27 94.5 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF4320 PF14208.1 KOG96504.1 - 0.0094 15.8 0.1 0.014 15.3 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4320) Retrotrans_gag PF03732.12 KOG96504.1 - 0.093 12.8 0.2 0.18 11.9 0.0 1.6 2 1 0 2 2 2 0 Retrotransposon gag protein YchF-GTPase_C PF06071.8 KOG96505.1 - 6.8e-33 112.3 0.0 1.4e-32 111.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 KOG96505.1 - 5.6e-14 52.0 0.1 1.5e-13 50.7 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 KOG96505.1 - 0.00075 19.2 0.0 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 KOG96505.1 - 0.00079 18.7 0.0 0.0017 17.6 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_14 PF13173.1 KOG96505.1 - 0.093 12.6 0.3 0.76 9.6 0.0 2.7 3 2 0 3 3 3 0 AAA domain ABC_tran PF00005.22 KOG96505.1 - 0.5 10.6 2.1 9.7 6.4 0.1 2.5 2 1 0 2 2 2 0 ABC transporter AAA_23 PF13476.1 KOG96505.1 - 0.78 10.0 8.2 7.9 6.7 5.7 2.4 1 1 0 1 1 1 0 AAA domain OTU PF02338.14 KOG96506.1 - 9.8e-24 84.2 0.2 9.8e-24 84.2 0.1 2.0 2 1 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 KOG96506.1 - 3.1e-05 23.4 1.0 3.1e-05 23.4 0.7 2.6 2 1 0 2 2 2 1 Peptidase C65 Otubain Astro_capsid PF03115.9 KOG96506.1 - 3 6.0 10.3 4 5.5 7.2 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor UDPGP PF01704.13 KOG96507.1 - 1.5e-130 435.5 1.1 1.7e-130 435.2 0.7 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Pribosyl_synth PF14572.1 KOG96508.1 - 1.4e-41 142.2 2.7 5.1e-36 124.1 1.5 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 KOG96508.1 - 2.4e-37 127.2 0.6 1.1e-36 125.0 0.0 2.2 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 KOG96508.1 - 2.4e-11 43.4 0.9 7.7e-11 41.8 0.7 1.8 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.1 KOG96508.1 - 0.022 13.9 0.2 0.036 13.2 0.1 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Chlorosome_CsmC PF11098.3 KOG96508.1 - 0.11 12.1 0.9 0.25 11.0 0.6 1.5 1 0 0 1 1 1 0 Chlorosome envelope protein C BRAP2 PF07576.7 KOG96509.1 - 4.9e-33 113.0 2.6 6.8e-32 109.3 0.3 2.5 2 0 0 2 2 2 1 BRCA1-associated protein 2 zf-UBP PF02148.14 KOG96509.1 - 3.4e-21 75.1 6.8 3.4e-21 75.1 4.7 1.7 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.1 KOG96509.1 - 3.3e-10 39.6 11.1 3.3e-10 39.6 7.7 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 KOG96509.1 - 1.1e-05 25.0 11.0 1.1e-05 25.0 7.6 2.3 2 1 1 3 3 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KOG96509.1 - 2e-05 24.4 10.8 2e-05 24.4 7.5 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOG96509.1 - 4.5e-05 23.0 6.3 0.00029 20.5 4.3 2.5 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.20 KOG96509.1 - 4.9e-05 22.8 10.8 0.00014 21.4 7.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOG96509.1 - 8e-05 22.6 5.7 8e-05 22.6 4.0 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger zf-Apc11 PF12861.2 KOG96509.1 - 0.0017 18.1 5.0 0.0065 16.2 3.5 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 KOG96509.1 - 0.0022 17.5 7.9 0.0056 16.2 5.5 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Baculo_RING PF05883.6 KOG96509.1 - 0.014 15.2 1.9 0.046 13.5 1.3 1.9 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain V_ATPase_I PF01496.14 KOG96509.1 - 1.7 6.3 10.7 2.7 5.7 7.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Viral_P18 PF04521.8 KOG96509.1 - 2.6 7.4 14.7 0.58 9.6 3.7 2.6 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein Prok-RING_4 PF14447.1 KOG96509.1 - 4.1 7.0 10.5 24 4.5 4.1 2.7 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 bZIP_1 PF00170.16 KOG96510.1 - 3.8e-09 36.3 15.5 7.1e-09 35.5 10.8 1.5 1 0 0 1 1 1 1 bZIP transcription factor DUF1875 PF08961.5 KOG96510.1 - 0.014 14.7 6.0 0.023 14.0 4.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1875) V_ATPase_I PF01496.14 KOG96510.1 - 0.021 12.7 4.2 0.028 12.2 2.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RIC3 PF15361.1 KOG96510.1 - 0.041 14.1 1.2 0.11 12.7 0.9 1.8 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 bZIP_2 PF07716.10 KOG96510.1 - 0.053 13.3 16.4 0.13 12.0 11.3 1.7 1 0 0 1 1 1 0 Basic region leucine zipper Glutaredoxin2_C PF04399.8 KOG96510.1 - 0.081 12.5 5.1 0.096 12.2 2.6 1.7 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain dsrm PF00035.20 KOG96510.1 - 0.49 11.0 4.7 0.84 10.2 0.6 3.0 4 0 0 4 4 4 0 Double-stranded RNA binding motif DUF1985 PF09331.6 KOG96510.1 - 0.51 10.1 3.0 0.89 9.3 1.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1985) IncA PF04156.9 KOG96510.1 - 0.91 9.0 7.4 1.7 8.2 5.1 1.4 1 0 0 1 1 1 0 IncA protein TSC22 PF01166.13 KOG96510.1 - 1.4 8.9 5.7 0.64 10.0 1.2 2.3 1 1 1 2 2 2 0 TSC-22/dip/bun family Form_Nir_trans PF01226.12 KOG96511.1 - 1.5e-66 223.8 23.4 1.9e-66 223.5 16.2 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter Pkinase PF00069.20 KOG96512.1 - 3.2e-72 242.8 0.0 5.4e-72 242.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96512.1 - 5.6e-47 160.0 0.0 9.6e-47 159.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 KOG96512.1 - 2.4e-22 79.0 0.0 1.4e-21 76.6 0.0 2.5 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.1 KOG96512.1 - 0.00018 20.5 0.0 0.00032 19.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like ANAPC15 PF15243.1 KOG96512.1 - 0.01 15.9 4.5 0.01 15.9 3.1 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 APH PF01636.18 KOG96512.1 - 0.12 12.0 0.0 0.93 9.1 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family IstB_IS21_ATP PF08483.6 KOG96513.1 - 0.16 11.6 0.8 0.31 10.7 0.6 1.5 1 0 0 1 1 1 0 IstB-like ATP binding N-terminal Ribosomal_S2 PF00318.15 KOG96514.1 - 3.1e-60 202.9 0.0 9.2e-60 201.4 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S2 TRAM_LAG1_CLN8 PF03798.11 KOG96515.1 - 5.5e-35 120.7 25.2 5.5e-35 120.7 17.5 2.5 2 1 0 2 2 2 1 TLC domain TRAM1 PF08390.6 KOG96515.1 - 1.4e-23 82.1 1.6 1.4e-23 82.1 1.1 1.8 2 0 0 2 2 2 1 TRAM1-like protein MOSP_C PF02722.10 KOG96515.1 - 0.064 12.7 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 Major Outer Sheath Protein C-terminal region VHS PF00790.14 KOG96516.1 - 5e-38 129.9 0.7 1.1e-37 128.7 0.5 1.6 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.23 KOG96516.1 - 1.3e-15 56.5 0.0 3.1e-15 55.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOG96516.1 - 3e-13 49.1 0.0 5.2e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOG96516.1 - 5.2e-12 45.0 0.0 1.1e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain UIM PF02809.15 KOG96516.1 - 0.023 14.2 0.7 0.075 12.6 0.5 2.0 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF4337 PF14235.1 KOG96516.1 - 3.1 7.5 7.9 6.8 6.4 4.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Ribosomal_L14e PF01929.12 KOG96517.1 - 4.7e-32 110.1 0.4 8.2e-32 109.3 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.24 KOG96517.1 - 0.00056 19.5 0.4 0.0012 18.4 0.3 1.6 1 0 0 1 1 1 1 KOW motif Oxysterol_BP PF01237.13 KOG96518.1 - 1.3e-91 306.7 0.0 1.6e-91 306.4 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein QCR10 PF09796.4 KOG96519.1 - 3.4e-28 97.0 0.0 4e-28 96.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) UCR_6-4kD PF08997.5 KOG96519.1 - 0.0042 16.7 0.1 0.0054 16.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex, 6.4kD protein Mito_carr PF00153.22 KOG96520.1 - 5.1e-62 205.6 0.1 5.4e-21 74.1 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein ThiF PF00899.16 KOG96521.1 - 3.2e-34 117.6 0.0 6.7e-34 116.6 0.0 1.5 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 KOG96521.1 - 0.0002 21.4 0.0 0.00032 20.8 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 KOG96521.1 - 0.0025 17.8 0.1 0.0077 16.2 0.0 1.9 2 0 0 2 2 2 1 TrkA-N domain Glyco_hydro_17 PF00332.13 KOG96521.1 - 0.0075 15.3 0.0 0.013 14.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 NAD_binding_7 PF13241.1 KOG96521.1 - 0.017 15.3 0.0 0.047 13.9 0.0 2.0 1 1 0 1 1 1 0 Putative NAD(P)-binding XdhC_C PF13478.1 KOG96521.1 - 0.019 15.2 0.0 0.15 12.3 0.0 2.2 1 1 1 2 2 2 0 XdhC Rossmann domain ApbA PF02558.11 KOG96521.1 - 0.021 14.2 0.0 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DAO PF01266.19 KOG96521.1 - 0.027 13.3 0.0 0.051 12.4 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase NIF PF03031.13 KOG96522.1 - 2.4e-51 173.5 0.0 4.4e-51 172.6 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Plasmodium_Vir PF05795.6 KOG96522.1 - 2 7.5 10.7 0.042 13.0 1.7 1.9 1 1 1 2 2 2 0 Plasmodium vivax Vir protein G-alpha PF00503.15 KOG96523.1 - 1.2e-124 415.9 8.1 1.5e-124 415.6 5.6 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 KOG96523.1 - 6e-16 58.1 0.8 1.1e-10 41.0 0.0 2.8 2 1 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 KOG96523.1 - 0.00041 20.8 0.1 0.37 11.2 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein Gtr1_RagA PF04670.7 KOG96523.1 - 0.00042 19.5 0.5 0.069 12.2 0.1 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_22 PF13401.1 KOG96523.1 - 0.032 14.3 0.4 0.72 9.9 0.0 2.5 1 1 0 2 2 2 0 AAA domain GTP_EFTU PF00009.22 KOG96523.1 - 0.064 12.6 0.0 2.1 7.7 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOG96523.1 - 0.088 12.7 0.0 13 5.7 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.1 KOG96523.1 - 0.1 12.1 0.1 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain zf-Tim10_DDP PF02953.10 KOG96524.1 - 4.2e-24 83.6 4.3 5.1e-24 83.3 3.0 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.8 KOG96524.1 - 0.014 14.8 3.3 0.018 14.5 2.3 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) Tom5 PF10642.4 KOG96524.1 - 0.024 14.2 0.9 0.049 13.2 0.7 1.5 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase zf-C2H2 PF00096.21 KOG96525.1 - 1e-05 25.5 11.2 0.0019 18.4 2.3 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG96525.1 - 0.00074 19.6 11.5 0.0065 16.7 1.1 3.7 3 0 0 3 3 3 1 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KOG96525.1 - 0.028 14.6 0.8 0.028 14.6 0.6 3.7 3 1 0 3 3 3 0 Zinc-finger double domain zf-C2H2_jaz PF12171.3 KOG96525.1 - 0.043 13.9 6.2 15 5.8 0.1 4.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding p450 PF00067.17 KOG96526.1 - 1.3e-113 379.9 0.0 1.5e-113 379.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DNA_pol_B_palm PF14792.1 KOG96526.1 - 0.03 14.3 0.0 0.074 13.1 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase beta palm Sod_Fe_C PF02777.13 KOG96527.1 - 4.6e-38 129.3 0.1 9.7e-38 128.2 0.1 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 KOG96527.1 - 8.1e-25 86.9 0.7 1.7e-24 85.8 0.5 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Imm15 PF15590.1 KOG96527.1 - 0.034 13.2 0.2 0.38 9.8 0.0 2.5 3 0 0 3 3 3 0 Immunity protein 15 HHH_2 PF12826.2 KOG96527.1 - 0.091 12.6 0.0 0.29 11.0 0.0 1.8 2 0 0 2 2 2 0 Helix-hairpin-helix motif DAO PF01266.19 KOG96528.1 - 8.7e-81 271.5 0.0 4.6e-56 190.2 0.0 2.0 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 KOG96528.1 - 6.1e-07 29.3 0.1 1.8e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.9 KOG96528.1 - 0.00065 18.4 0.1 0.018 13.6 0.1 2.2 2 0 0 2 2 2 1 Tryptophan halogenase Pyr_redox PF00070.22 KOG96528.1 - 0.0043 17.4 0.0 0.01 16.1 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 KOG96528.1 - 0.02 13.9 0.0 0.034 13.2 0.0 1.2 1 0 0 1 1 1 0 Thi4 family DUF3403 PF11883.3 KOG96528.1 - 0.032 14.5 0.6 0.075 13.3 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3403) NAD_binding_9 PF13454.1 KOG96528.1 - 0.13 12.0 0.1 0.23 11.2 0.1 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding tRNA-synt_2b PF00587.20 KOG96529.1 - 1e-24 87.0 0.0 2e-24 86.1 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 KOG96529.1 - 2.1e-05 24.4 4.9 2.1e-05 24.4 3.4 1.7 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain DUF641 PF04859.7 KOG96529.1 - 0.0012 18.5 2.2 0.0025 17.5 1.4 1.7 1 1 0 1 1 1 1 Plant protein of unknown function (DUF641) DUF724 PF05266.9 KOG96529.1 - 0.0097 15.5 1.1 0.021 14.4 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF724) IncA PF04156.9 KOG96529.1 - 0.016 14.7 2.6 0.03 13.9 1.8 1.4 1 0 0 1 1 1 0 IncA protein Lebercilin PF15619.1 KOG96529.1 - 0.039 13.3 4.7 0.076 12.4 3.3 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Reo_sigmaC PF04582.7 KOG96529.1 - 0.13 11.3 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Spc7 PF08317.6 KOG96529.1 - 0.14 10.8 5.4 0.24 10.0 3.7 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Mnd1 PF03962.10 KOG96529.1 - 0.35 10.5 5.9 0.15 11.7 2.3 1.6 2 0 0 2 2 2 0 Mnd1 family Fib_alpha PF08702.5 KOG96529.1 - 2.5 8.2 9.9 1 9.4 4.7 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Metallophos_2 PF12850.2 KOG96530.1 - 1.6e-14 54.0 0.0 2.2e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Acetyltransf_1 PF00583.19 KOG96531.1 - 9e-17 60.8 0.0 1.5e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 KOG96531.1 - 1.9e-05 24.3 0.0 3.5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 KOG96531.1 - 5.6e-05 23.2 0.0 0.00013 22.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KOG96531.1 - 0.0042 17.2 0.0 0.0082 16.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KOG96531.1 - 0.0058 16.8 0.0 0.0082 16.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 KOG96531.1 - 0.02 14.7 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 KOG96531.1 - 0.03 13.9 0.1 0.062 12.9 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Tn7_Tnp_TnsA_N PF08722.6 KOG96533.1 - 0.024 14.5 0.1 0.15 12.0 0.1 2.4 1 0 0 1 1 1 0 TnsA endonuclease N terminal Usp PF00582.21 KOG96533.1 - 0.029 14.5 0.0 0.053 13.7 0.0 1.4 1 0 0 1 1 1 0 Universal stress protein family Cpn10 PF00166.16 KOG96534.1 - 5.8e-26 90.2 0.4 7.4e-26 89.9 0.3 1.1 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit DUF2611 PF11022.3 KOG96535.1 - 1.9e-21 75.9 2.2 9.9e-21 73.6 1.6 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF2611) DUF4094 PF13334.1 KOG96535.1 - 0.071 13.4 0.0 0.086 13.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) RNA_Me_trans PF04252.8 KOG96536.1 - 1.1e-89 299.0 0.1 1.2e-89 298.9 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase DDHD PF02862.12 KOG96537.1 - 3.1e-46 158.0 0.2 1.3e-29 103.6 0.0 3.7 2 2 1 3 3 3 2 DDHD domain LCAT PF02450.10 KOG96537.1 - 0.00012 21.1 0.9 0.0016 17.5 0.0 2.2 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase DUF2305 PF10230.4 KOG96537.1 - 0.0063 15.9 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_5 PF12695.2 KOG96537.1 - 0.02 14.6 0.0 0.054 13.2 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOG96537.1 - 0.043 13.3 0.0 0.088 12.3 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.20 KOG96537.1 - 0.13 11.8 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_6 PF12697.2 KOG96537.1 - 0.22 11.3 0.0 0.49 10.2 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF3439 PF11921.3 KOG96538.1 - 0.0089 15.7 0.2 0.029 14.1 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) SIR2 PF02146.12 KOG96539.1 - 1.1e-34 119.7 0.0 1e-33 116.5 0.0 2.1 1 1 0 1 1 1 1 Sir2 family V_ATPase_I PF01496.14 KOG96539.1 - 0.2 9.4 0.6 0.3 8.9 0.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family WD40 PF00400.27 KOG96540.1 - 1.4e-10 40.6 2.3 0.00031 20.5 0.1 4.2 4 1 0 4 4 4 3 WD domain, G-beta repeat Nucleoporin_N PF08801.6 KOG96540.1 - 0.012 14.3 0.0 2.7 6.6 0.1 2.3 2 0 0 2 2 2 0 Nup133 N terminal like eIF2A PF08662.6 KOG96540.1 - 0.071 12.8 0.0 0.21 11.3 0.0 1.7 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A TPR_11 PF13414.1 KOG96541.1 - 6.8e-55 182.6 31.0 1.6e-16 59.6 0.1 6.3 3 3 4 7 7 7 7 TPR repeat TPR_1 PF00515.23 KOG96541.1 - 2.6e-46 153.3 18.3 1.1e-07 31.1 0.1 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.12 KOG96541.1 - 1.7e-32 108.6 22.5 4.5e-06 26.1 0.1 9.6 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_12 PF13424.1 KOG96541.1 - 3.1e-19 68.7 19.9 1.9e-06 27.7 1.2 6.2 4 2 2 7 7 6 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOG96541.1 - 3.7e-18 65.6 16.4 0.00093 19.8 0.0 6.9 3 3 4 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.1 KOG96541.1 - 1e-17 62.4 22.3 0.00026 20.5 0.1 8.9 8 1 1 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.1 KOG96541.1 - 3.2e-16 58.3 14.7 0.037 14.6 0.0 9.3 5 3 5 10 10 8 4 Tetratricopeptide repeat TPR_17 PF13431.1 KOG96541.1 - 6.8e-15 53.9 9.2 0.0078 16.3 0.0 8.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOG96541.1 - 1.5e-13 49.4 15.3 0.0095 15.6 0.1 7.6 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOG96541.1 - 2e-11 44.0 19.6 0.0081 16.4 0.4 7.1 4 3 3 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.1 KOG96541.1 - 5.4e-09 35.7 1.0 0.00011 21.9 0.0 4.9 5 2 0 5 5 5 1 Tetratricopeptide repeat Apc3 PF12895.2 KOG96541.1 - 8.8e-06 25.7 12.6 0.15 12.2 1.4 4.4 3 2 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.4 KOG96541.1 - 0.00073 18.7 2.4 7.2 5.9 0.0 6.0 7 0 0 7 7 7 0 SHNi-TPR DUF3808 PF10300.4 KOG96541.1 - 0.0014 17.2 5.0 0.0031 16.1 0.0 2.8 2 1 0 2 2 2 1 Protein of unknown function (DUF3808) TPR_10 PF13374.1 KOG96541.1 - 0.014 15.3 6.5 2 8.4 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_20 PF14561.1 KOG96541.1 - 0.015 15.3 13.5 0.32 11.1 0.3 5.4 4 3 2 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOG96541.1 - 0.031 14.7 22.5 14 6.4 0.1 8.3 8 0 0 8 8 8 0 Tetratricopeptide repeat Ten1_2 PF15490.1 KOG96541.1 - 0.044 13.3 0.1 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 Telomere-capping, CST complex subunit MAS20 PF02064.10 KOG96541.1 - 0.36 10.7 6.1 6 6.7 0.0 3.8 2 1 0 3 3 3 0 MAS20 protein import receptor XPC-binding PF09280.6 KOG96541.1 - 0.49 9.9 8.1 0.066 12.6 2.0 2.3 2 1 0 2 2 2 0 XPC-binding domain TPR_4 PF07721.9 KOG96541.1 - 3.3 8.4 11.8 4.9 7.8 0.3 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat bZIP_1 PF00170.16 KOG96542.1 - 1.1e-11 44.5 7.5 1.9e-11 43.7 5.2 1.4 1 0 0 1 1 1 1 bZIP transcription factor HALZ PF02183.13 KOG96542.1 - 0.071 12.8 0.2 0.15 11.7 0.1 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper Med30 PF11315.3 KOG96542.1 - 0.16 12.0 1.4 0.37 10.9 1.0 1.7 1 1 0 1 1 1 0 Mediator complex subunit 30 bZIP_Maf PF03131.12 KOG96542.1 - 0.18 12.1 3.1 0.39 11.0 2.2 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor Sec2p PF06428.6 KOG96542.1 - 0.29 11.0 2.7 0.55 10.1 1.8 1.5 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p PalH PF08733.5 KOG96543.1 - 7.3e-87 291.4 16.2 9.5e-87 291.0 11.2 1.1 1 0 0 1 1 1 1 PalH/RIM21 DUF2499 PF10693.4 KOG96543.1 - 6.1 6.9 13.1 0.77 9.8 0.3 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2499) Metallothi_Euk2 PF12809.2 KOG96544.1 - 2e-08 34.4 49.1 2.5e-08 34.1 34.1 1.1 1 0 0 1 1 1 1 Eukaryotic metallothionein HLH PF00010.21 KOG96545.1 - 3.4e-20 71.4 0.3 6.8e-20 70.5 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain XPG_N PF00752.12 KOG96546.1 - 4.2e-32 110.4 0.0 1.4e-31 108.7 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.13 KOG96546.1 - 1e-22 79.9 0.0 4e-22 78.0 0.0 2.1 2 0 0 2 2 2 1 XPG I-region HHH_2 PF12826.2 KOG96546.1 - 0.0013 18.5 0.0 0.035 13.9 0.0 2.8 3 0 0 3 3 3 1 Helix-hairpin-helix motif 5_3_exonuc PF01367.15 KOG96546.1 - 0.0029 17.7 0.0 0.015 15.5 0.0 2.2 2 1 1 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.2 KOG96546.1 - 0.0035 16.8 0.2 0.054 12.9 0.0 2.3 2 1 0 2 2 2 1 XPG domain containing Ank_2 PF12796.2 KOG96547.1 - 2.8e-41 139.7 0.4 3.1e-17 62.7 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOG96547.1 - 3.4e-26 89.7 3.0 2.8e-08 33.1 0.1 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.1 KOG96547.1 - 5.3e-24 84.1 4.8 3.2e-09 37.0 0.1 4.9 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOG96547.1 - 1.9e-22 78.7 7.0 4e-08 33.2 0.1 4.5 2 2 2 4 4 4 4 Ankyrin repeats (many copies) zf-DHHC PF01529.15 KOG96547.1 - 9.3e-22 77.2 5.2 9.3e-22 77.2 3.6 2.5 3 0 0 3 3 3 1 DHHC palmitoyltransferase Ank_3 PF13606.1 KOG96547.1 - 2e-18 64.6 3.2 4e-05 23.4 0.0 6.2 6 0 0 6 6 6 3 Ankyrin repeat UNC45-central PF11701.3 KOG96548.1 - 2.3e-28 98.8 4.6 2.3e-28 98.8 3.2 3.7 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central Syntaxin_2 PF14523.1 KOG96549.1 - 1e-20 73.6 13.1 3.4e-20 71.9 2.8 2.5 2 0 0 2 2 2 2 Syntaxin-like protein SNARE PF05739.14 KOG96549.1 - 8.8e-20 70.1 3.8 8.8e-20 70.1 2.6 2.8 3 0 0 3 3 3 1 SNARE domain Hemocyanin_M PF00372.14 KOG96549.1 - 0.018 14.3 0.1 0.018 14.3 0.1 1.9 2 1 1 3 3 3 0 Hemocyanin, copper containing domain Synaptobrevin PF00957.16 KOG96549.1 - 0.022 14.3 2.0 0.022 14.3 1.4 2.8 4 0 0 4 4 4 0 Synaptobrevin Rogdi_lz PF10259.4 KOG96549.1 - 0.049 12.7 3.1 0.083 11.9 2.2 1.5 1 1 0 1 1 1 0 Rogdi leucine zipper containing protein BLOC1_2 PF10046.4 KOG96549.1 - 0.069 13.2 15.3 0.28 11.3 0.5 3.5 1 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2077 PF09850.4 KOG96549.1 - 0.077 12.3 0.4 0.22 10.8 0.0 2.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2077) V-SNARE PF05008.10 KOG96549.1 - 0.1 12.7 6.8 0.22 11.6 0.2 3.4 2 2 2 4 4 4 0 Vesicle transport v-SNARE protein N-terminus Sigma_reg_N PF13800.1 KOG96549.1 - 0.35 10.9 3.5 1.1 9.2 2.5 1.9 1 0 0 1 1 1 0 Sigma factor regulator N-terminal PRA-PH PF01503.12 KOG96549.1 - 0.43 10.9 2.1 8.2 6.7 0.3 2.5 2 0 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase DUF2120 PF09893.4 KOG96549.1 - 1.6 8.6 0.0 1.6 8.6 0.0 3.0 1 1 2 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) DUF733 PF05306.6 KOG96549.1 - 3.4 8.0 6.2 2.2 8.6 1.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF733) ISG65-75 PF11727.3 KOG96549.1 - 4.2 6.3 12.0 3.1 6.7 3.8 2.1 2 0 0 2 2 2 0 Invariant surface glycoprotein FAD_binding_6 PF00970.19 KOG96550.1 - 1.7e-06 28.0 0.0 1.5e-05 25.0 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain Hira PF07569.6 KOG96551.1 - 1.1e-86 289.5 1.8 2e-85 285.4 0.4 2.7 2 0 0 2 2 2 1 TUP1-like enhancer of split WD40 PF00400.27 KOG96551.1 - 3.8e-05 23.4 0.4 2.3 8.2 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat CK_II_beta PF01214.13 KOG96552.1 - 1.9e-72 242.6 0.1 2.3e-72 242.3 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Lactamase_B PF00753.22 KOG96553.1 - 7.3e-18 64.9 0.0 1.2e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 KOG96553.1 - 0.00011 21.7 0.5 0.0002 20.9 0.3 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain CUE PF02845.11 KOG96554.1 - 5.3e-11 41.7 0.0 9e-11 41.0 0.0 1.4 1 0 0 1 1 1 1 CUE domain DEAD PF00270.24 KOG96558.1 - 6.2e-36 123.4 1.2 4.2e-35 120.7 0.3 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG96558.1 - 1e-26 92.5 0.1 2e-26 91.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOG96558.1 - 9.5e-05 22.2 0.9 0.00018 21.4 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 KOG96558.1 - 0.0041 17.1 0.0 0.037 13.9 0.0 2.2 2 0 0 2 2 2 1 Helicase C-terminal domain AAA_30 PF13604.1 KOG96558.1 - 0.0094 15.5 0.0 0.021 14.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOG96558.1 - 0.013 15.6 0.2 0.067 13.3 0.0 2.1 1 1 1 2 2 2 0 AAA domain XRN_N PF03159.13 KOG96560.1 - 2.7e-108 360.8 1.7 5.4e-108 359.8 0.0 2.4 3 0 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus RTA1 PF04479.8 KOG96561.1 - 6.3e-94 313.6 9.3 8.4e-94 313.2 6.5 1.2 1 0 0 1 1 1 1 RTA1 like protein Nro1 PF12753.2 KOG96562.1 - 7.6e-159 528.9 22.4 8.7e-159 528.7 15.5 1.0 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 TPR_11 PF13414.1 KOG96562.1 - 0.0064 16.1 0.8 0.094 12.3 0.9 2.8 3 0 0 3 3 3 1 TPR repeat TPR_19 PF14559.1 KOG96562.1 - 0.0072 16.6 1.4 0.7 10.2 1.3 3.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOG96562.1 - 0.016 15.7 0.6 4.4 8.2 0.1 3.9 2 1 1 3 3 3 0 Tetratricopeptide repeat SQS_PSY PF00494.14 KOG96562.1 - 0.024 13.9 0.0 0.07 12.4 0.0 1.7 1 1 0 1 1 1 0 Squalene/phytoene synthase zf-AN1 PF01428.11 KOG96563.1 - 2.2e-09 37.0 13.0 3.5e-09 36.3 9.0 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger Phage_CRI PF05144.9 KOG96563.1 - 0.23 10.5 1.8 0.31 10.0 1.0 1.5 1 1 1 2 2 2 0 Phage replication protein CRI Transp_Tc5_C PF04236.10 KOG96563.1 - 0.81 9.9 8.6 1.5 9.0 5.9 1.4 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain Flavoprotein PF02441.14 KOG96564.1 - 6.6e-44 148.6 0.4 4.3e-43 146.0 0.3 2.1 1 1 0 1 1 1 1 Flavoprotein Nop14 PF04147.7 KOG96564.1 - 0.0017 16.4 18.8 0.0017 16.4 13.0 1.6 2 0 0 2 2 2 1 Nop14-like family NOB1_Zn_bind PF08772.6 KOG96565.1 - 8.5e-27 92.7 0.6 2.3e-26 91.3 0.4 1.8 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN PF01850.16 KOG96565.1 - 0.036 14.3 0.0 0.075 13.3 0.0 1.5 1 0 0 1 1 1 0 PIN domain zf-FCS PF06467.9 KOG96565.1 - 0.16 11.6 1.4 0.4 10.3 1.0 1.8 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif SGS PF05002.10 KOG96566.1 - 9e-30 102.2 0.3 3.5e-29 100.3 0.2 2.0 1 0 0 1 1 1 1 SGS domain CS PF04969.11 KOG96566.1 - 1.5e-15 57.5 0.8 3.6e-15 56.2 0.2 2.0 2 0 0 2 2 2 1 CS domain Apc3 PF12895.2 KOG96566.1 - 0.00099 19.2 2.2 0.4 10.8 0.2 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 KOG96566.1 - 0.16 12.6 0.1 13 6.7 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOG96566.1 - 0.18 11.4 4.9 3.6 7.2 0.4 2.4 1 1 0 2 2 2 0 TPR repeat TPR_8 PF13181.1 KOG96566.1 - 0.26 11.1 2.2 0.55 10.1 0.8 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOG96566.1 - 2 8.5 4.8 6.9 6.8 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat MAP65_ASE1 PF03999.7 KOG96567.1 - 3.2e-172 574.3 33.5 4.2e-172 573.9 23.2 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) DUF676 PF05057.9 KOG96568.1 - 3.1e-60 203.1 0.0 4.3e-60 202.7 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 KOG96568.1 - 3.2e-05 23.6 0.0 5.6e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein FSH1 PF03959.8 KOG96568.1 - 0.0018 17.7 0.0 0.003 17.0 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DUF2427 PF10348.4 KOG96568.1 - 0.04 13.4 0.3 0.077 12.5 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) Abhydrolase_5 PF12695.2 KOG96568.1 - 0.056 13.2 0.0 0.19 11.5 0.0 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family Pkinase PF00069.20 KOG96570.1 - 1.5e-52 178.3 0.0 2e-52 177.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96570.1 - 1.5e-16 60.3 0.0 2.1e-16 59.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOG96570.1 - 4e-07 30.0 0.0 2.3e-06 27.5 0.0 2.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 KOG96570.1 - 0.0082 15.7 0.1 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Ribosomal_L3 PF00297.17 KOG96573.1 - 9.6e-122 405.4 8.5 1.2e-121 405.1 5.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 PHD PF00628.24 KOG96574.1 - 1.1e-07 31.4 7.3 2e-07 30.5 5.1 1.5 1 0 0 1 1 1 1 PHD-finger ING PF12998.2 KOG96574.1 - 0.011 15.9 0.8 0.029 14.6 0.6 1.7 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding zf-HC5HC2H PF13771.1 KOG96574.1 - 0.035 14.2 1.5 0.058 13.5 0.6 1.7 1 1 0 1 1 1 0 PHD-like zinc-binding domain Ecl1 PF12855.2 KOG96574.1 - 0.045 13.0 1.5 0.16 11.2 0.5 2.2 2 0 0 2 2 2 0 Life-span regulatory factor DUF1647 PF07801.6 KOG96574.1 - 0.078 12.4 0.3 0.15 11.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1647) Cytochrom_C1 PF02167.10 KOG96575.1 - 2.3e-83 279.1 0.0 2.8e-83 278.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.1 KOG96575.1 - 0.00059 19.9 0.0 0.0012 18.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.16 KOG96575.1 - 0.0053 17.5 0.5 0.012 16.3 0.1 1.9 2 1 0 2 2 2 1 Cytochrome c DUF1528 PF07515.6 KOG96576.1 - 0.03 14.3 0.5 0.072 13.1 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1528) Alg6_Alg8 PF03155.10 KOG96577.1 - 9.3e-168 558.8 44.0 1.1e-167 558.6 30.5 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Glyco_transf_56 PF07429.6 KOG96577.1 - 0.016 14.1 2.4 0.14 11.0 0.3 2.1 2 0 0 2 2 2 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 Vps5 PF09325.5 KOG96578.1 - 3.2e-73 245.8 13.4 4.9e-73 245.2 9.3 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 KOG96578.1 - 4.5e-22 77.9 2.4 8.4e-22 77.0 0.2 2.5 3 0 0 3 3 3 1 PX domain DUF2045 PF09741.4 KOG96578.1 - 0.03 13.4 0.1 0.087 11.9 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2045) DUF4363 PF14276.1 KOG96578.1 - 0.04 13.6 1.7 0.1 12.3 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) RabGAP-TBC PF00566.13 KOG96579.1 - 7.8e-50 169.3 3.3 7.8e-50 169.3 2.3 2.0 3 0 0 3 3 3 1 Rab-GTPase-TBC domain DUF3446 PF11928.3 KOG96579.1 - 0.017 15.2 3.1 0.017 15.2 2.2 4.9 3 2 1 4 4 4 0 Domain of unknown function (DUF3446) DUF1656 PF07869.7 KOG96580.1 - 0.1 12.4 0.0 0.3 10.9 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1656) Shugoshin_N PF07558.6 KOG96581.1 - 1.7e-14 53.2 5.2 6.6e-14 51.3 3.6 2.1 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.6 KOG96581.1 - 5.8e-11 41.6 2.4 5.8e-11 41.6 1.7 2.3 2 0 0 2 2 2 1 Shugoshin C terminus SMC_hinge PF06470.8 KOG96581.1 - 0.037 13.9 0.6 0.1 12.5 0.4 1.8 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain FHIPEP PF00771.15 KOG96581.1 - 1.1 7.5 6.7 0.14 10.4 0.7 2.0 2 0 0 2 2 2 0 FHIPEP family Syntaxin-18_N PF10496.4 KOG96582.1 - 1.2e-16 60.2 1.1 4.1e-16 58.5 0.7 2.0 1 0 0 1 1 1 1 SNARE-complex protein Syntaxin-18 N-terminus BMFP PF04380.8 KOG96582.1 - 0.0073 16.4 1.8 0.018 15.1 0.1 2.6 2 1 0 2 2 2 1 Membrane fusogenic activity GTP_EFTU PF00009.22 KOG96583.1 - 4.9e-28 97.8 0.0 8.6e-28 97.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOG96583.1 - 2.1e-06 27.6 0.2 6.2e-06 26.1 0.1 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KOG96583.1 - 0.002 18.5 0.2 0.1 13.0 0.0 3.2 2 1 0 2 2 2 1 Miro-like protein DUF258 PF03193.11 KOG96583.1 - 0.0049 16.0 0.0 0.012 14.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 KOG96583.1 - 0.052 13.0 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Kin17_mid PF10357.4 KOG96584.1 - 7.2e-34 116.1 0.2 1e-33 115.6 0.1 1.2 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.3 KOG96584.1 - 5.3e-06 26.4 3.3 1.1e-05 25.3 2.3 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KOG96584.1 - 8.6e-05 22.5 3.5 0.00021 21.3 2.4 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type FANCF PF11107.3 KOG96584.1 - 0.029 13.6 0.7 0.4 9.8 0.1 2.1 2 0 0 2 2 2 0 Fanconi anemia group F protein (FANCF) zf-C2H2_2 PF12756.2 KOG96584.1 - 0.11 12.5 0.3 0.11 12.5 0.2 1.9 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) LIN37 PF15306.1 KOG96584.1 - 0.24 11.3 2.4 0.23 11.4 0.3 2.0 1 1 1 2 2 2 0 LIN37 zf-C2H2 PF00096.21 KOG96584.1 - 0.34 11.3 2.3 1.1 9.7 1.6 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type U3_snoRNA_assoc PF08297.6 KOG96585.1 - 1.3e-22 79.8 7.9 1.3e-22 79.8 5.5 2.4 2 1 0 2 2 2 1 U3 snoRNA associated DUF3409 PF11889.3 KOG96585.1 - 0.077 12.7 1.4 0.27 10.9 0.9 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3409) Glyco_transf_92 PF01697.22 KOG96585.1 - 0.086 12.1 3.9 0.1 11.8 2.7 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 92 DUF940 PF06082.6 KOG96585.1 - 0.71 8.3 10.2 0.84 8.1 7.1 1.0 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) V_ATPase_I PF01496.14 KOG96585.1 - 6.5 4.4 12.7 6.8 4.4 8.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Zip PF02535.17 KOG96586.1 - 1.3e-48 165.6 10.1 2.5e-46 158.1 7.0 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter TPR_11 PF13414.1 KOG96587.1 - 8.4e-11 41.3 0.0 1e-05 25.0 0.0 2.8 1 1 1 2 2 2 2 TPR repeat LRR_4 PF12799.2 KOG96587.1 - 2.4e-05 23.8 18.5 0.018 14.6 0.6 6.1 3 1 3 6 6 6 3 Leucine Rich repeats (2 copies) F-box PF00646.28 KOG96587.1 - 0.00025 20.5 0.4 0.00077 19.0 0.3 1.9 1 0 0 1 1 1 1 F-box domain TPR_12 PF13424.1 KOG96587.1 - 0.0011 18.8 0.1 0.31 11.0 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOG96587.1 - 0.0012 18.6 0.0 4.5 7.4 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat F-box-like PF12937.2 KOG96587.1 - 0.002 17.7 0.2 0.0051 16.4 0.2 1.7 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.28 KOG96587.1 - 0.023 14.6 15.3 14 6.1 0.0 7.6 8 0 0 8 8 6 0 Leucine Rich Repeat TPR_1 PF00515.23 KOG96587.1 - 0.023 14.2 0.0 16 5.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat F-box-like_2 PF13013.1 KOG96587.1 - 0.032 13.9 5.2 0.86 9.3 0.1 3.6 4 0 0 4 4 4 0 F-box-like domain MAS20 PF02064.10 KOG96587.1 - 0.045 13.6 0.2 0.38 10.6 0.0 2.4 2 1 0 2 2 2 0 MAS20 protein import receptor Apc3 PF12895.2 KOG96587.1 - 0.083 13.0 1.8 1.8 8.7 0.9 2.9 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 LRR_7 PF13504.1 KOG96587.1 - 0.15 12.3 9.8 47 4.8 0.0 6.8 7 0 0 7 7 5 0 Leucine rich repeat LRR_8 PF13855.1 KOG96587.1 - 0.45 10.3 17.1 17 5.2 0.3 7.3 5 3 2 7 7 7 0 Leucine rich repeat Abhydrolase_6 PF12697.2 KOG96588.1 - 2e-28 99.8 0.0 2.9e-28 99.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOG96588.1 - 2e-06 27.6 0.1 5.4e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOG96588.1 - 0.0014 18.2 0.1 0.0043 16.6 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.15 KOG96588.1 - 0.0025 17.3 0.0 0.0035 16.8 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.16 KOG96588.1 - 0.071 12.3 0.1 0.19 10.9 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family OST3_OST6 PF04756.8 KOG96589.1 - 5e-35 120.4 11.6 1e-34 119.4 8.0 1.5 1 0 0 1 1 1 1 OST3 / OST6 family C2 PF00168.25 KOG96590.1 - 2.6e-55 184.2 6.8 6.5e-19 67.5 0.1 4.6 4 0 0 4 4 4 4 C2 domain Ion_trans PF00520.26 KOG96591.1 - 0.0017 17.6 18.6 0.041 13.1 12.9 2.4 1 1 0 1 1 1 1 Ion transport protein DUF106 PF01956.11 KOG96591.1 - 0.047 13.2 3.6 1 8.8 0.1 2.7 2 0 0 2 2 2 0 Integral membrane protein DUF106 Ras PF00071.17 KOG96592.1 - 1.6e-60 203.2 0.0 1.9e-60 202.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG96592.1 - 1.5e-19 70.6 0.0 2.4e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOG96592.1 - 6.4e-18 64.5 0.1 7.7e-18 64.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOG96592.1 - 3.6e-10 39.3 0.0 4.7e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOG96592.1 - 5.5e-07 29.2 0.0 1e-06 28.3 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOG96592.1 - 1.6e-05 24.8 0.0 2.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arch_ATPase PF01637.13 KOG96592.1 - 0.06 13.0 0.1 0.13 11.9 0.0 1.4 1 1 0 1 1 1 0 Archaeal ATPase PP2C PF00481.16 KOG96593.1 - 6.4e-53 179.7 0.0 1.2e-52 178.9 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C PMBR PF09373.5 KOG96593.1 - 0.041 13.8 0.0 20 5.3 0.0 3.0 3 0 0 3 3 3 0 Pseudomurein-binding repeat zf-CCCH PF00642.19 KOG96594.1 - 0.0032 17.1 0.4 0.0032 17.1 0.3 2.1 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3412 PF11892.3 KOG96594.1 - 0.041 13.7 0.1 1.5 8.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3412) Mem_trans PF03547.13 KOG96595.1 - 1.3e-101 339.7 3.3 1.5e-101 339.4 2.3 1.1 1 0 0 1 1 1 1 Membrane transport protein Adeno_E3B PF03376.9 KOG96595.1 - 0.027 14.3 0.1 0.098 12.5 0.1 1.9 1 0 0 1 1 1 0 Adenovirus E3B protein AMP-binding PF00501.23 KOG96596.1 - 4.9e-34 117.4 0.0 6e-14 51.2 0.0 5.1 5 0 0 5 5 5 5 AMP-binding enzyme DMAP_binding PF06464.6 KOG96596.1 - 2.1e-22 79.7 3.8 6.2e-22 78.2 2.6 1.9 1 0 0 1 1 1 1 DMAP1-binding Domain Arf PF00025.16 KOG96597.1 - 6.1e-72 240.5 0.2 7e-72 240.3 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 KOG96597.1 - 1.7e-14 53.4 0.1 2.1e-14 53.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 KOG96597.1 - 3e-14 52.5 1.8 7.8e-10 37.9 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 KOG96597.1 - 1.1e-12 47.6 0.0 1.4e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 KOG96597.1 - 8.1e-11 41.5 0.0 9.8e-11 41.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 KOG96597.1 - 1.7e-08 34.9 0.0 2.8e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 KOG96597.1 - 5.7e-05 23.0 0.0 7.2e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.13 KOG96597.1 - 0.15 11.1 0.2 0.25 10.3 0.1 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Rib_5-P_isom_A PF06026.9 KOG96598.1 - 6.5e-56 188.3 0.0 8.2e-56 188.0 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.17 KOG96598.1 - 0.0029 17.2 0.0 0.21 11.1 0.0 2.3 1 1 0 1 1 1 1 DeoR C terminal sensor domain CaATP_NAI PF12515.3 KOG96598.1 - 0.15 11.5 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain Ribosomal_S7e PF01251.13 KOG96599.1 - 2.4e-81 271.7 2.7 2.9e-81 271.5 1.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e DUF4265 PF14085.1 KOG96599.1 - 0.097 12.4 0.0 1.2 8.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4265) Nup_retrotrp_bd PF10599.4 KOG96601.1 - 8.3e-11 42.4 31.0 8.3e-11 42.4 21.5 10.1 2 1 4 6 6 6 1 Retro-transposon transporting motif Glyco_transf_15 PF01793.11 KOG96602.1 - 5.5e-145 482.4 10.9 6.9e-145 482.1 7.6 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PsbJ PF01788.12 KOG96602.1 - 0.079 12.5 1.4 0.15 11.5 1.0 1.4 1 0 0 1 1 1 0 PsbJ Mito_carr PF00153.22 KOG96603.1 - 6.8e-60 198.8 6.4 1.1e-20 73.1 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ras PF00071.17 KOG96604.1 - 1.1e-55 187.4 0.1 1.5e-55 187.0 0.1 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG96604.1 - 7.1e-21 74.9 0.1 1.1e-20 74.2 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOG96604.1 - 4.5e-08 32.5 0.0 6.1e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KOG96604.1 - 4.2e-05 23.0 0.0 0.00015 21.2 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOG96604.1 - 4.8e-05 23.2 0.0 8.4e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOG96604.1 - 0.029 13.6 0.2 0.072 12.3 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_25 PF13481.1 KOG96604.1 - 0.083 12.2 0.1 0.14 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain DAD PF02109.11 KOG96605.1 - 1.1e-40 138.2 7.5 1.2e-40 138.0 5.2 1.0 1 0 0 1 1 1 1 DAD family DUF2207 PF09972.4 KOG96605.1 - 0.046 12.3 2.3 0.053 12.1 1.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EVI2A PF05399.6 KOG96606.1 - 0.5 9.5 3.1 11 5.1 0.1 2.2 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) SNARE PF05739.14 KOG96607.1 - 1.2e-16 60.1 7.1 1.2e-16 60.1 4.9 2.0 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.1 KOG96607.1 - 4.4e-05 23.4 3.0 4.4e-05 23.4 2.1 4.1 2 2 1 3 3 3 2 Syntaxin-like protein Synaptobrevin PF00957.16 KOG96607.1 - 0.0019 17.7 1.8 0.0019 17.7 1.2 2.4 3 0 0 3 3 3 1 Synaptobrevin Herpes_US9 PF06072.6 KOG96607.1 - 0.0025 17.6 0.2 0.0047 16.7 0.1 1.4 1 0 0 1 1 1 1 Alphaherpesvirus tegument protein US9 Tweety PF04906.8 KOG96607.1 - 8 4.7 8.8 3.1 6.0 3.6 1.8 1 1 1 2 2 2 0 Tweety RGS PF00615.14 KOG96608.1 - 4.7e-11 42.8 2.4 4.7e-11 42.8 1.7 2.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain HMGL-like PF00682.14 KOG96609.1 - 4.3e-76 255.6 0.0 6.9e-76 255.0 0.0 1.3 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 KOG96609.1 - 1.4e-27 96.0 0.8 2.8e-27 95.1 0.6 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain CGI-121 PF08617.5 KOG96609.1 - 0.062 12.9 0.1 0.18 11.4 0.1 1.8 1 0 0 1 1 1 0 Kinase binding protein CGI-121 Syja_N PF02383.13 KOG96610.1 - 2.8e-92 308.9 0.9 4.3e-92 308.2 0.6 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 KOG96610.1 - 2.3e-25 89.9 0.0 4.3e-25 89.0 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family His_Phos_1 PF00300.17 KOG96611.1 - 5.8e-24 84.9 0.0 1.2e-23 83.8 0.0 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) TFIIIC_sub6 PF10419.4 KOG96611.1 - 1.4e-17 62.7 0.1 1e-16 60.0 0.0 2.2 2 0 0 2 2 2 1 TFIIIC subunit Maf PF02545.9 KOG96612.1 - 2.6e-63 212.6 0.0 2.9e-63 212.5 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein HEAT PF02985.17 KOG96613.1 - 0.0022 17.9 0.1 4.5 7.6 0.0 4.1 4 0 0 4 4 4 2 HEAT repeat CLASP_N PF12348.3 KOG96613.1 - 0.048 13.0 0.1 0.63 9.3 0.0 2.6 2 1 1 3 3 3 0 CLASP N terminal zf-H2C2_2 PF13465.1 KOG96614.1 - 3.2e-22 77.6 21.1 1.5e-08 34.4 0.6 4.6 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.21 KOG96614.1 - 7.4e-20 70.0 23.5 2.7e-05 24.2 0.1 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG96614.1 - 2.8e-14 52.3 22.2 0.00074 19.6 0.2 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOG96614.1 - 1.6e-05 24.9 13.8 0.14 12.3 0.1 4.8 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KOG96614.1 - 9.8e-05 22.4 13.9 0.0015 18.6 0.2 4.9 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-Di19 PF05605.7 KOG96614.1 - 0.00024 21.1 6.9 0.0034 17.4 0.3 2.7 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.1 KOG96614.1 - 0.017 15.0 13.5 0.72 9.8 0.2 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger zf-CHCC PF10276.4 KOG96614.1 - 0.57 10.0 10.0 2.8 7.8 0.7 3.2 3 0 0 3 3 3 0 Zinc-finger domain zf-C2H2_2 PF12756.2 KOG96614.1 - 9.3 6.4 11.5 3.5 7.7 0.8 4.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-CHY PF05495.7 KOG96615.1 - 0.029 14.5 0.7 0.061 13.4 0.5 1.5 1 0 0 1 1 1 0 CHY zinc finger COX4 PF02936.9 KOG96615.1 - 0.034 13.8 2.3 0.15 11.7 0.1 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV RIG-I_C-RD PF11648.3 KOG96615.1 - 0.085 12.7 2.1 1.4 8.8 0.2 2.7 2 0 0 2 2 2 0 C-terminal domain of RIG-I KRAB PF01352.22 KOG96615.1 - 0.17 11.3 0.7 0.72 9.3 0.1 2.2 2 0 0 2 2 2 0 KRAB box TRAPP PF04051.11 KOG96616.1 - 1e-36 125.7 1.0 2e-36 124.7 0.2 1.8 2 1 0 2 2 2 1 Transport protein particle (TRAPP) component RNA_pol_Rpb1_5 PF04998.12 KOG96617.1 - 5.1e-98 327.7 0.0 7.5e-98 327.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.7 KOG96617.1 - 9.7e-81 271.6 0.0 1.4e-80 271.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.15 KOG96617.1 - 9.4e-70 233.8 0.0 1.9e-69 232.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 KOG96617.1 - 3.1e-38 130.9 0.0 9.7e-38 129.3 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 KOG96617.1 - 1.5e-30 105.1 0.0 3.6e-30 103.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 AAA PF00004.24 KOG96618.1 - 4.9e-42 143.2 0.0 1.1e-41 142.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOG96618.1 - 2.1e-05 24.2 1.1 8.7e-05 22.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 KOG96618.1 - 2.2e-05 24.4 0.0 0.00013 21.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 KOG96618.1 - 2.9e-05 24.1 0.4 0.011 15.6 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.7 KOG96618.1 - 0.00061 18.9 0.0 0.0013 17.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOG96618.1 - 0.0013 18.8 2.8 0.0071 16.4 0.2 2.8 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOG96618.1 - 0.002 18.0 0.4 0.016 15.1 0.0 2.6 3 0 0 3 3 3 1 AAA domain PhoH PF02562.11 KOG96618.1 - 0.0036 16.5 0.1 0.032 13.4 0.1 2.2 2 0 0 2 2 2 1 PhoH-like protein AAA_17 PF13207.1 KOG96618.1 - 0.0058 17.4 0.1 0.019 15.7 0.0 2.0 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.8 KOG96618.1 - 0.0072 15.2 0.0 0.015 14.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.1 KOG96618.1 - 0.01 15.5 0.2 0.025 14.3 0.1 1.6 1 0 0 1 1 1 0 Part of AAA domain IstB_IS21 PF01695.12 KOG96618.1 - 0.01 15.2 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.16 KOG96618.1 - 0.012 14.7 0.1 0.038 13.1 0.0 1.8 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 KOG96618.1 - 0.022 14.1 0.7 0.21 10.9 0.1 2.2 1 1 1 2 2 2 0 AAA domain BLOC1_2 PF10046.4 KOG96618.1 - 0.032 14.3 2.8 0.072 13.2 1.1 2.2 2 0 0 2 2 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_14 PF13173.1 KOG96618.1 - 0.033 14.0 0.2 0.093 12.6 0.0 1.8 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.17 KOG96618.1 - 0.033 14.3 0.0 0.13 12.4 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.1 KOG96618.1 - 0.071 12.6 1.2 0.14 11.7 0.1 2.0 2 0 0 2 2 2 0 AAA domain DUF1192 PF06698.6 KOG96618.1 - 0.11 12.3 2.0 0.27 11.0 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) KaiC PF06745.8 KOG96618.1 - 0.13 11.3 1.6 0.26 10.3 0.0 2.2 3 0 0 3 3 3 0 KaiC ThylakoidFormat PF11264.3 KOG96618.1 - 0.54 9.8 4.9 0.66 9.5 2.4 1.8 2 0 0 2 2 2 0 Thylakoid formation protein TLD PF07534.11 KOG96619.1 - 4.4e-28 98.0 0.1 3.4e-27 95.1 0.1 2.3 1 1 1 2 2 2 1 TLD DUF4268 PF14088.1 KOG96619.1 - 2.6 7.6 6.1 0.98 9.0 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4268) RIO1 PF01163.17 KOG96620.1 - 2.9e-73 245.2 1.0 2.9e-73 245.2 0.7 2.5 3 0 0 3 3 3 1 RIO1 family APH PF01636.18 KOG96620.1 - 0.018 14.8 0.3 0.89 9.2 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Aldo_ket_red PF00248.16 KOG96621.1 - 5.3e-55 186.2 0.0 6.2e-55 186.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Profilin PF00235.14 KOG96622.1 - 9.5e-27 93.5 0.0 1e-26 93.3 0.0 1.0 1 0 0 1 1 1 1 Profilin NTNH_C PF08470.5 KOG96622.1 - 0.092 12.3 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Nontoxic nonhaemagglutinin C-terminal Leo1 PF04004.8 KOG96623.1 - 1.5e-46 158.2 0.6 1.5e-46 158.2 0.4 3.2 3 1 0 3 3 3 1 Leo1-like protein UCH PF00443.24 KOG96624.1 - 2e-62 210.7 6.1 4.1e-62 209.7 4.2 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.1 KOG96624.1 - 5e-42 141.1 11.8 2.8e-19 68.2 0.5 4.7 4 0 0 4 4 4 4 A repeated domain in UCH-protein UCH_1 PF13423.1 KOG96624.1 - 4.4e-08 32.9 14.2 0.00026 20.5 0.6 3.8 4 1 0 4 4 4 2 Ubiquitin carboxyl-terminal hydrolase Col_cuticle_N PF01484.12 KOG96624.1 - 0.0087 15.7 0.4 0.021 14.4 0.3 1.6 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain His_kinase PF06580.8 KOG96624.1 - 0.35 10.8 6.9 0.53 10.2 0.0 3.9 4 0 0 4 4 4 0 Histidine kinase COQ7 PF03232.8 KOG96625.1 - 3.1e-74 248.1 0.0 3.8e-74 247.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Lipase_GDSL PF00657.17 KOG96626.1 - 9.5e-24 84.5 0.0 1.2e-23 84.2 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.1 KOG96626.1 - 3.2e-17 63.2 0.0 4.1e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family DUF4440 PF14534.1 KOG96626.1 - 0.02 15.1 0.0 0.046 13.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) RhoGAP PF00620.22 KOG96627.1 - 9.2e-46 155.2 0.6 3.8e-45 153.2 0.1 2.2 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.17 KOG96627.1 - 2.6e-10 40.1 30.8 5.7e-06 26.3 8.1 2.5 2 0 0 2 2 2 2 LIM domain APG6 PF04111.7 KOG96627.1 - 0.0067 15.5 7.6 0.022 13.8 5.3 1.8 1 0 0 1 1 1 1 Autophagy protein Apg6 DUF724 PF05266.9 KOG96627.1 - 0.046 13.3 6.0 0.13 11.9 4.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF3086 PF11285.3 KOG96627.1 - 0.079 11.7 2.1 4.2 6.1 1.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3086) IncA PF04156.9 KOG96627.1 - 1.4 8.4 9.9 0.039 13.5 1.2 2.5 3 0 0 3 3 3 0 IncA protein V_ATPase_I PF01496.14 KOG96627.1 - 2.1 6.0 6.6 0.49 8.1 2.0 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family AIRC PF00731.15 KOG96628.1 - 5.3e-64 214.0 1.7 8.8e-64 213.3 1.2 1.4 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.17 KOG96628.1 - 7.1e-63 211.0 0.0 1.5e-62 209.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.1 KOG96628.1 - 3.3e-08 33.4 0.0 6.9e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain 2-Hacid_dh_C PF02826.14 KOG96628.1 - 6.2e-05 22.2 0.1 0.00024 20.2 0.0 2.0 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Dala_Dala_lig_C PF07478.8 KOG96628.1 - 0.0056 16.1 0.0 0.09 12.1 0.0 2.6 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.12 KOG96628.1 - 0.028 13.7 0.0 0.049 12.9 0.0 1.5 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain TrkA_N PF02254.13 KOG96628.1 - 0.045 13.7 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain ATPgrasp_Ter PF15632.1 KOG96628.1 - 0.053 12.2 0.0 0.51 9.0 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon Afi1 PF07792.7 KOG96629.1 - 3.7e-40 137.2 0.3 7.9e-40 136.2 0.2 1.6 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.5 KOG96629.1 - 4.4e-25 87.5 0.0 9.3e-25 86.5 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Mito_carr PF00153.22 KOG96630.1 - 1.7e-61 203.9 2.8 2.4e-21 75.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein HAD_2 PF13419.1 KOG96631.1 - 2.6e-15 57.0 0.0 4.7e-14 52.9 0.0 2.0 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOG96631.1 - 4.8e-12 46.7 0.0 8.8e-08 32.8 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOG96631.1 - 3.1e-10 39.6 0.0 5.8e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.2 KOG96631.1 - 0.0038 17.3 0.0 0.0071 16.5 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 KOG96631.1 - 0.0038 16.5 0.0 0.25 10.6 0.0 2.3 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase Hydrolase_3 PF08282.7 KOG96631.1 - 0.021 14.4 1.7 2.6 7.5 0.0 3.0 3 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase DUF1680 PF07944.7 KOG96631.1 - 0.073 11.3 0.0 0.099 10.8 0.0 1.1 1 0 0 1 1 1 0 Putative glycosyl hydrolase of unknown function (DUF1680) PX PF00787.19 KOG96632.1 - 1.2e-11 44.3 0.4 3.2e-11 43.0 0.3 1.7 1 0 0 1 1 1 1 PX domain Vps5 PF09325.5 KOG96632.1 - 2.5e-05 23.6 9.9 5.1e-05 22.6 6.8 1.4 1 0 0 1 1 1 1 Vps5 C terminal like GTP_EFTU PF00009.22 KOG96633.1 - 3.4e-63 212.4 0.2 4.9e-63 211.9 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 KOG96633.1 - 1.7e-36 124.4 0.1 6.8e-36 122.4 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.19 KOG96633.1 - 3e-21 75.0 0.0 7.9e-21 73.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 KOG96633.1 - 1.2e-13 50.7 0.0 3.8e-13 49.0 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 KOG96633.1 - 4.4e-12 45.9 0.0 4.4e-12 45.9 0.0 2.9 5 0 0 5 5 5 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KOG96633.1 - 9.4e-06 25.5 0.2 1.9e-05 24.6 0.2 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 KOG96633.1 - 0.067 12.6 0.8 0.3 10.5 0.4 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RhoGAP PF00620.22 KOG96634.1 - 1.5e-35 122.0 0.0 3.6e-35 120.8 0.0 1.6 2 0 0 2 2 2 1 RhoGAP domain Iso_dh PF00180.15 KOG96635.1 - 5.9e-103 344.4 0.0 6.6e-103 344.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Metallophos PF00149.23 KOG96636.1 - 2.4e-08 33.6 0.1 2e-07 30.5 0.1 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase UBA PF00627.26 KOG96637.1 - 2e-10 40.1 0.0 4.9e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.1 KOG96637.1 - 0.00022 20.6 0.0 0.00054 19.4 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain CUE PF02845.11 KOG96637.1 - 0.015 14.7 0.0 0.079 12.4 0.0 2.3 1 1 0 1 1 1 0 CUE domain PsiA PF06952.6 KOG96637.1 - 0.025 13.6 0.0 0.045 12.7 0.0 1.3 1 0 0 1 1 1 0 PsiA protein V-ATPase_G PF03179.10 KOG96637.1 - 1 9.7 4.7 0.86 9.9 1.9 1.9 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit HSF_DNA-bind PF00447.12 KOG96638.1 - 7.2e-36 122.5 0.6 7.2e-36 122.5 0.4 3.5 3 0 0 3 3 3 1 HSF-type DNA-binding Zip PF02535.17 KOG96638.1 - 0.55 9.1 16.5 0.44 9.5 6.2 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter RR_TM4-6 PF06459.7 KOG96638.1 - 1.6 8.5 17.3 1.6 8.5 7.1 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Actin PF00022.14 KOG96639.1 - 3.7e-28 98.0 0.0 1.5e-21 76.3 0.0 3.5 2 2 0 2 2 2 2 Actin MreB_Mbl PF06723.8 KOG96639.1 - 0.00047 18.8 0.0 0.013 14.0 0.0 2.3 2 0 0 2 2 2 1 MreB/Mbl protein Nop14 PF04147.7 KOG96639.1 - 0.011 13.7 29.5 0.02 12.8 20.5 1.4 1 0 0 1 1 1 0 Nop14-like family CENP-T PF15511.1 KOG96639.1 - 0.24 10.6 20.6 0.45 9.7 14.3 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T CoA_binding PF02629.14 KOG96640.1 - 2.8e-27 95.0 3.0 7.7e-27 93.6 0.9 2.2 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.14 KOG96640.1 - 1.3e-24 86.5 0.7 2.1e-24 85.8 0.5 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.1 KOG96640.1 - 8e-08 31.9 0.6 1.4e-07 31.2 0.0 1.6 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 KOG96640.1 - 2.2e-06 27.8 0.1 5.3e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 CoA binding domain IlvN PF07991.7 KOG96640.1 - 0.038 13.3 0.6 0.33 10.3 0.0 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain Toprim_Crpt PF13342.1 KOG96640.1 - 0.052 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase TPK_catalytic PF04263.11 KOG96641.1 - 6.9e-24 83.7 0.0 2.8e-19 68.8 0.0 2.7 3 0 0 3 3 3 2 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.9 KOG96641.1 - 9.2e-15 54.1 0.1 2.5e-14 52.7 0.1 1.8 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain RE_SinI PF09570.5 KOG96641.1 - 0.03 13.3 0.1 0.051 12.5 0.1 1.4 1 0 0 1 1 1 0 SinI restriction endonuclease BAF PF02961.9 KOG96642.1 - 0.2 11.9 1.0 1.1 9.6 0.5 2.4 2 0 0 2 2 2 0 Barrier to autointegration factor KH_1 PF00013.24 KOG96643.1 - 0.00027 20.5 0.2 0.00081 18.9 0.2 1.8 1 0 0 1 1 1 1 KH domain MDM31_MDM32 PF08118.6 KOG96644.1 - 1.2e-44 152.6 19.4 3.6e-21 75.2 1.9 5.0 2 1 2 4 4 4 4 Yeast mitochondrial distribution and morphology (MDM) proteins TACC PF05010.9 KOG96644.1 - 0.03 14.0 0.0 0.083 12.6 0.0 1.7 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) G-patch_2 PF12656.2 KOG96645.1 - 2.3e-20 72.2 0.6 2.3e-20 72.2 0.4 1.8 2 0 0 2 2 2 1 DExH-box splicing factor binding site DUF3245 PF11595.3 KOG96645.1 - 0.0056 16.9 0.2 0.0056 16.9 0.1 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF3245) Glyco_transf_22 PF03901.12 KOG96646.1 - 1.5e-83 281.1 30.5 1.7e-83 280.9 21.1 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Ribosomal_L13 PF00572.13 KOG96647.1 - 2.7e-43 147.0 0.2 3.4e-43 146.7 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 RNA_pol_Rpb2_6 PF00562.23 KOG96648.1 - 8.7e-126 419.7 0.2 1.6e-125 418.9 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 KOG96648.1 - 2.2e-72 242.2 0.1 3.3e-72 241.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 KOG96648.1 - 1.3e-51 174.7 0.0 2.3e-51 173.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 KOG96648.1 - 2.8e-30 104.3 0.1 6.9e-30 103.1 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.8 KOG96648.1 - 1.1e-28 98.7 1.2 2.2e-28 97.8 0.3 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.11 KOG96648.1 - 6.9e-22 76.9 0.1 1.8e-21 75.6 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 KOG96648.1 - 8e-19 67.3 0.9 1.9e-18 66.1 0.6 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 ABC2_membrane PF01061.19 KOG96650.1 - 2.8e-84 281.5 62.1 1.5e-45 154.9 17.6 2.5 3 0 0 3 3 2 2 ABC-2 type transporter PDR_CDR PF06422.7 KOG96650.1 - 3.7e-41 138.9 13.3 4.7e-39 132.1 0.2 3.5 3 0 0 3 3 3 2 CDR ABC transporter ABC_tran PF00005.22 KOG96650.1 - 1.4e-39 135.5 0.1 3.1e-18 66.3 0.0 3.3 3 0 0 3 3 3 2 ABC transporter ABC_trans_N PF14510.1 KOG96650.1 - 4.2e-24 84.4 0.1 1.3e-23 82.8 0.0 1.9 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 KOG96650.1 - 8.2e-09 35.1 0.0 4.9e-05 22.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 KOG96650.1 - 1.3e-06 28.5 0.3 9.7e-05 22.4 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain cobW PF02492.14 KOG96650.1 - 1.1e-05 24.9 0.6 0.0078 15.6 0.0 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain DUF258 PF03193.11 KOG96650.1 - 2.3e-05 23.6 0.0 0.0012 18.0 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function, DUF258 AAA_18 PF13238.1 KOG96650.1 - 7.2e-05 23.0 1.3 0.032 14.5 0.0 3.1 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.1 KOG96650.1 - 0.00019 21.1 0.2 0.55 10.0 0.0 2.5 2 0 0 2 2 2 2 Part of AAA domain AAA_33 PF13671.1 KOG96650.1 - 0.0002 21.2 0.0 0.05 13.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.14 KOG96650.1 - 0.00032 19.9 0.1 0.0083 15.3 0.0 2.9 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOG96650.1 - 0.00034 20.6 0.0 0.0039 17.2 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_29 PF13555.1 KOG96650.1 - 0.00042 19.7 0.7 0.0049 16.3 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC2_membrane_3 PF12698.2 KOG96650.1 - 0.00044 19.3 12.9 0.00044 19.3 9.0 3.7 2 1 0 3 3 2 2 ABC-2 family transporter protein NACHT PF05729.7 KOG96650.1 - 0.0019 17.8 0.2 2 8.0 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_28 PF13521.1 KOG96650.1 - 0.0022 17.9 0.2 0.1 12.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOG96650.1 - 0.0039 17.3 0.6 0.63 10.1 0.0 3.3 4 0 0 4 4 2 1 AAA domain UPF0079 PF02367.12 KOG96650.1 - 0.0045 16.6 0.3 0.71 9.5 0.1 2.5 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_23 PF13476.1 KOG96650.1 - 0.0053 17.1 1.4 0.11 12.8 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KOG96650.1 - 0.0059 17.4 0.0 0.68 10.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_13 PF13166.1 KOG96650.1 - 0.0093 14.4 0.9 5.9 5.2 0.0 3.6 4 0 0 4 4 4 1 AAA domain Arch_ATPase PF01637.13 KOG96650.1 - 0.023 14.3 0.0 3.2 7.3 0.0 3.0 3 0 0 3 3 3 0 Archaeal ATPase AAA_10 PF12846.2 KOG96650.1 - 0.1 12.0 0.1 18 4.6 0.1 2.5 2 0 0 2 2 2 0 AAA-like domain PduV-EutP PF10662.4 KOG96650.1 - 0.16 11.4 0.8 2.3 7.7 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Sad1_UNC PF07738.8 KOG96651.1 - 1e-33 116.0 0.1 2.1e-33 114.9 0.1 1.6 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal ISN1 PF06437.6 KOG96652.1 - 2e-182 606.5 0.0 2.2e-182 606.3 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase PINIT PF14324.1 KOG96653.1 - 1.5e-26 93.2 0.2 4.5e-26 91.6 0.0 1.9 2 0 0 2 2 2 1 PINIT domain zf-MIZ PF02891.15 KOG96653.1 - 1.3e-20 72.6 11.0 2.3e-20 71.8 7.6 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.22 KOG96653.1 - 2.4e-09 36.4 0.9 4.2e-09 35.6 0.6 1.4 1 0 0 1 1 1 1 SAP domain zf-Nse PF11789.3 KOG96653.1 - 3.6e-05 23.1 4.5 0.00012 21.5 3.1 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KOG96653.1 - 0.089 12.5 4.2 0.068 12.9 0.9 2.3 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.1 KOG96653.1 - 0.94 9.2 4.7 1.9 8.2 3.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOG96653.1 - 2.7 7.8 7.4 6.1 6.7 5.2 1.6 1 0 0 1 1 1 0 Ring finger domain Proteasome PF00227.21 KOG96654.1 - 7.7e-49 165.5 0.1 1.2e-48 164.9 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.3 KOG96654.1 - 1.9e-16 58.9 0.0 4e-16 57.9 0.0 1.6 1 0 0 1 1 1 1 Proteasome beta subunits C terminal LSM PF01423.17 KOG96656.1 - 3e-14 52.3 0.2 3.7e-14 52.0 0.1 1.1 1 0 0 1 1 1 1 LSM domain Xpo1 PF08389.7 KOG96657.1 - 1.7e-26 92.8 7.3 1.7e-26 92.8 5.1 4.0 4 0 0 4 4 4 1 Exportin 1-like protein IBN_N PF03810.14 KOG96657.1 - 0.00013 21.8 1.9 0.0023 17.8 0.6 3.5 3 1 0 3 3 3 1 Importin-beta N-terminal domain Choline_transpo PF04515.7 KOG96658.1 - 4.1e-90 301.8 19.5 4.1e-90 301.8 13.5 2.1 2 0 0 2 2 2 1 Plasma-membrane choline transporter DUF1749 PF08538.5 KOG96659.1 - 2.7e-99 331.8 0.0 3.2e-99 331.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.2 KOG96659.1 - 5e-14 52.7 2.6 6.4e-14 52.3 1.8 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOG96659.1 - 1.2e-09 38.0 0.0 3.7e-09 36.4 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOG96659.1 - 0.00015 21.4 1.3 0.00039 20.0 0.9 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOG96659.1 - 0.00068 18.9 0.0 0.33 10.1 0.0 2.4 1 1 1 2 2 2 2 Prolyl oligopeptidase family LCAT PF02450.10 KOG96659.1 - 0.052 12.5 0.0 0.067 12.1 0.0 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Ser_hydrolase PF06821.8 KOG96659.1 - 0.12 11.9 0.0 3.6 7.1 0.0 2.4 2 0 0 2 2 2 0 Serine hydrolase Chlorophyllase PF07224.6 KOG96659.1 - 0.15 10.8 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Zn_clus PF00172.13 KOG96660.1 - 2.5e-09 36.8 9.6 5.7e-09 35.7 6.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 KOG96660.1 - 0.0013 17.6 0.1 0.0027 16.6 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain NUDIX PF00293.23 KOG96661.1 - 2.6e-19 69.1 0.2 3.2e-19 68.9 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain DUF410 PF04190.8 KOG96662.1 - 4.1e-97 324.7 4.0 4.9e-97 324.5 2.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) DUF2802 PF10975.3 KOG96662.1 - 0.079 12.7 0.1 0.21 11.4 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2802) RHD3 PF05879.7 KOG96663.1 - 6.8e-288 956.6 13.3 7.8e-288 956.4 9.2 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.18 KOG96663.1 - 8.6e-05 22.4 0.0 0.00036 20.4 0.0 2.1 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 KOG96663.1 - 0.00029 20.7 0.1 0.00095 19.1 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KOG96663.1 - 0.004 17.6 0.4 0.013 15.9 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein B12D PF06522.6 KOG96663.1 - 0.041 13.5 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit PIN_4 PF13638.1 KOG96664.1 - 2.8e-32 111.5 0.1 6.7e-32 110.3 0.0 1.7 2 0 0 2 2 2 1 PIN domain Ribosomal_S28e PF01200.13 KOG96665.1 - 2.5e-33 113.6 4.1 2.6e-33 113.5 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e tRNA-synt_1c PF00749.16 KOG96666.1 - 2.6e-113 377.8 0.0 4.2e-113 377.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.10 KOG96666.1 - 1.4e-56 190.5 0.8 2.5e-56 189.7 0.5 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.13 KOG96666.1 - 3.1e-32 111.6 0.7 4e-31 108.0 0.1 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.10 KOG96666.1 - 1.3e-24 86.7 4.8 2.9e-24 85.5 3.3 1.6 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DAGK_cat PF00781.19 KOG96667.1 - 4.9e-26 90.6 0.0 8.8e-26 89.8 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain tify PF06200.9 KOG96667.1 - 0.17 11.2 0.0 0.33 10.2 0.0 1.4 1 0 0 1 1 1 0 tify domain Zn_clus PF00172.13 KOG96668.1 - 1.2e-07 31.4 9.9 3e-07 30.2 6.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DcpS PF05652.7 KOG96669.1 - 2.3e-37 127.7 0.0 3.6e-37 127.1 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.3 KOG96669.1 - 4.2e-33 114.0 0.2 1.1e-32 112.7 0.1 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Med4 PF10018.4 KOG96670.1 - 1.2e-38 132.4 3.9 6.2e-38 130.0 3.4 1.8 2 1 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 MBOAT PF03062.14 KOG96671.1 - 1.7e-68 231.1 9.3 1.7e-68 231.1 6.5 1.7 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Ferrochelatase PF00762.14 KOG96672.1 - 1.5e-92 309.9 0.0 1.8e-92 309.7 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase TetR_C_4 PF08359.6 KOG96673.1 - 0.0049 16.7 0.9 0.0049 16.7 0.6 3.1 4 0 0 4 4 4 2 YsiA-like protein, C-terminal region UPF0449 PF15136.1 KOG96673.1 - 0.0078 16.4 0.4 0.0078 16.4 0.3 4.4 1 1 3 4 4 4 2 Uncharacterised protein family UPF0449 LMWPc PF01451.16 KOG96673.1 - 0.26 11.5 0.1 0.26 11.5 0.0 2.6 3 0 0 3 3 3 0 Low molecular weight phosphotyrosine protein phosphatase CBM_21 PF03370.8 KOG96674.1 - 3.1e-27 94.8 6.2 1.1e-26 92.9 4.3 2.1 1 0 0 1 1 1 1 Putative phosphatase regulatory subunit Fcf2 PF08698.6 KOG96674.1 - 0.06 13.3 3.6 0.29 11.1 0.0 3.2 3 0 0 3 3 3 0 Fcf2 pre-rRNA processing CBM_25 PF03423.8 KOG96674.1 - 0.65 10.1 5.5 9.6 6.3 1.9 2.7 2 0 0 2 2 2 0 Carbohydrate binding domain (family 25) CPSF73-100_C PF11718.3 KOG96675.1 - 1.2e-23 83.5 1.6 1.4e-23 83.3 1.1 1.0 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term ECH PF00378.15 KOG96676.1 - 2.5e-16 59.5 0.0 8.3e-16 57.8 0.0 1.7 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family SPA PF08616.5 KOG96676.1 - 0.0059 16.3 0.1 0.011 15.4 0.1 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Init_tRNA_PT PF04179.7 KOG96676.1 - 0.11 11.3 0.1 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase WH1 PF00568.18 KOG96677.1 - 2.3e-36 123.8 0.0 3.2e-36 123.4 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.15 KOG96677.1 - 3.8e-06 26.3 1.3 8e-06 25.2 0.9 1.6 1 0 0 1 1 1 1 WH2 motif Aminotran_5 PF00266.14 KOG96678.1 - 2.8e-33 115.1 0.0 3.7e-33 114.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Ras PF00071.17 KOG96679.1 - 1.5e-51 174.0 0.0 1.8e-51 173.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG96679.1 - 5.5e-18 65.5 0.0 1.2e-17 64.5 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 KOG96679.1 - 3.9e-12 45.7 0.0 5.2e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.17 KOG96679.1 - 0.00024 21.2 0.2 0.0019 18.3 0.2 2.1 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.7 KOG96679.1 - 0.0006 19.0 0.0 0.00082 18.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOG96679.1 - 0.0057 16.1 0.5 0.05 13.0 0.3 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 KOG96679.1 - 0.0092 15.2 0.0 0.015 14.4 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit KaiC PF06745.8 KOG96679.1 - 0.014 14.4 0.2 0.023 13.8 0.1 1.2 1 0 0 1 1 1 0 KaiC Pox_A32 PF04665.7 KOG96679.1 - 0.026 13.8 0.1 0.047 12.9 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein G-alpha PF00503.15 KOG96679.1 - 0.048 12.3 3.2 1.1 7.9 0.1 2.8 2 1 1 3 3 3 0 G-protein alpha subunit AAA_22 PF13401.1 KOG96679.1 - 0.057 13.5 0.2 0.17 12.0 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KOG96679.1 - 0.068 13.0 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KOG96679.1 - 0.12 12.0 0.1 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain GTP_EFTU PF00009.22 KOG96681.1 - 4e-61 205.7 0.3 5.2e-61 205.3 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 KOG96681.1 - 4.9e-27 93.9 0.0 1.3e-26 92.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 KOG96681.1 - 3.5e-19 68.7 1.0 9.6e-19 67.2 0.7 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 KOG96681.1 - 2.1e-05 24.0 0.1 5e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 KOG96681.1 - 3.9e-05 23.5 0.0 6.8e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KOG96681.1 - 0.002 18.5 0.0 0.0037 17.7 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein PduV-EutP PF10662.4 KOG96681.1 - 0.045 13.2 0.4 7.3 6.0 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DisA_N PF02457.11 KOG96681.1 - 0.046 12.8 0.2 0.14 11.2 0.0 1.9 2 0 0 2 2 2 0 DisA bacterial checkpoint controller nucleotide-binding CbiA PF01656.18 KOG96681.1 - 4.2 6.7 6.6 2.8e+02 0.7 4.6 2.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain INO80_Ies4 PF08193.6 KOG96682.1 - 0.0021 18.0 1.4 0.0021 18.0 1.0 1.8 1 1 1 2 2 2 1 INO80 complex subunit Ies4 Cellulase PF00150.13 KOG96683.1 - 8e-13 48.2 0.7 6.2e-12 45.3 0.2 2.0 1 1 1 2 2 2 1 Cellulase (glycosyl hydrolase family 5) SNF2_N PF00176.18 KOG96684.1 - 4e-64 216.2 0.0 4e-64 216.2 0.0 2.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOG96684.1 - 2e-10 40.4 0.0 5.3e-10 39.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.1 KOG96684.1 - 1.7e-05 24.4 2.5 4.1e-05 23.2 1.8 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KOG96684.1 - 0.00045 20.1 1.6 0.0012 18.8 1.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOG96684.1 - 0.00045 19.9 3.1 0.00094 18.9 2.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.1 KOG96684.1 - 0.0017 18.0 0.6 0.0054 16.4 0.4 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.20 KOG96684.1 - 0.0025 17.4 1.6 0.0063 16.1 1.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOG96684.1 - 0.0036 16.9 0.8 0.0079 15.8 0.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF3441 PF11923.3 KOG96684.1 - 0.016 14.7 0.6 0.085 12.4 0.4 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3441) Prok-RING_4 PF14447.1 KOG96684.1 - 0.088 12.3 0.6 0.24 10.9 0.4 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 PEX11 PF05648.9 KOG96685.1 - 0.0048 16.1 7.6 0.025 13.8 5.4 2.0 1 1 1 2 2 2 1 Peroxisomal biogenesis factor 11 (PEX11) DUF959 PF06121.9 KOG96685.1 - 0.047 13.3 0.0 0.09 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF959) TFIIA PF03153.8 KOG96686.1 - 6.3e-60 204.0 26.1 5.1e-34 118.7 10.3 2.0 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Z1 PF10593.4 KOG96686.1 - 1.2 8.3 8.3 0.12 11.5 1.7 1.9 2 0 0 2 2 2 0 Z1 domain Kinetocho_Slk19 PF12709.2 KOG96687.1 - 1.3e-30 105.2 17.9 1.3e-30 105.2 12.4 9.2 4 2 4 8 8 8 1 Central kinetochore-associated HrpB7 PF09486.5 KOG96687.1 - 0.0005 20.0 5.4 0.082 12.8 0.1 3.9 4 0 0 4 4 4 2 Bacterial type III secretion protein (HrpB7) IncA PF04156.9 KOG96687.1 - 0.067 12.7 99.9 1.5 8.4 11.1 7.0 1 1 6 7 7 7 0 IncA protein Spc7 PF08317.6 KOG96687.1 - 0.1 11.2 101.3 0.033 12.8 19.4 5.9 1 1 4 5 5 5 0 Spc7 kinetochore protein Radical_SAM PF04055.16 KOG96688.1 - 1.1e-13 51.6 0.0 2.2e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Peptidase_C14 PF00656.17 KOG96689.1 - 1e-68 231.7 0.0 1.3e-68 231.3 0.0 1.1 1 0 0 1 1 1 1 Caspase domain DUF605 PF04652.11 KOG96689.1 - 0.39 10.0 6.7 0.57 9.5 4.7 1.2 1 0 0 1 1 1 0 Vta1 like SpoU_methylase PF00588.14 KOG96691.1 - 1.5e-25 89.7 0.0 4.3e-25 88.2 0.0 1.8 1 1 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.7 KOG96691.1 - 1.6e-11 44.1 0.0 3.7e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding IGPD PF00475.13 KOG96692.1 - 1.3e-61 206.7 0.6 2e-61 206.1 0.4 1.3 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase Arena_RNA_pol PF06317.6 KOG96692.1 - 0.14 8.7 0.0 0.18 8.3 0.0 1.0 1 0 0 1 1 1 0 Arenavirus RNA polymerase DEAD PF00270.24 KOG96693.1 - 2.5e-47 160.5 0.0 3.8e-46 156.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG96693.1 - 1.6e-27 95.1 0.1 4.1e-27 93.8 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CMS1 PF14617.1 KOG96693.1 - 0.053 12.5 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF1253 PF06862.7 KOG96693.1 - 0.26 9.6 0.0 0.65 8.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1253) MMR_HSR1 PF01926.18 KOG96694.1 - 2.8e-09 36.9 0.0 7.7e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 KOG96694.1 - 0.00021 20.5 0.4 0.00061 19.0 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 KOG96694.1 - 0.002 17.4 0.0 0.0076 15.5 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Arch_ATPase PF01637.13 KOG96694.1 - 0.0092 15.7 0.3 0.043 13.5 0.0 2.0 2 0 0 2 2 2 1 Archaeal ATPase GTP_EFTU PF00009.22 KOG96694.1 - 0.015 14.7 0.1 0.9 8.9 0.1 2.4 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_10 PF12846.2 KOG96694.1 - 0.02 14.3 0.0 0.67 9.3 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain RNA_helicase PF00910.17 KOG96694.1 - 0.058 13.5 0.0 0.19 11.9 0.0 1.9 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.22 KOG96694.1 - 0.07 13.4 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 KOG96694.1 - 0.073 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain zf-AD PF07776.10 KOG96694.1 - 0.14 12.1 2.8 0.64 10.0 0.0 3.0 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) Noc2 PF03715.8 KOG96695.1 - 2.2e-128 427.3 3.8 2.2e-128 427.3 2.7 2.2 3 0 0 3 3 3 1 Noc2p family RNA_pol_Rpb2_6 PF00562.23 KOG96696.1 - 3.8e-120 401.1 0.1 3.8e-120 401.1 0.1 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 KOG96696.1 - 7.8e-62 207.8 1.6 1.3e-61 207.0 1.1 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 KOG96696.1 - 7.3e-44 149.4 3.4 1.9e-43 148.1 2.3 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 KOG96696.1 - 1.9e-30 104.9 0.1 5.8e-30 103.3 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.8 KOG96696.1 - 6.6e-26 89.9 1.4 1.5e-25 88.7 0.1 2.4 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.11 KOG96696.1 - 8.2e-19 67.1 0.0 1.8e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 KOG96696.1 - 1e-12 47.8 0.2 4.9e-12 45.6 0.1 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 DUF1528 PF07515.6 KOG96696.1 - 0.11 12.5 0.4 0.51 10.3 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1528) Y_phosphatase PF00102.22 KOG96697.1 - 2.6e-67 226.5 0.4 4.6e-67 225.7 0.3 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 KOG96697.1 - 0.0029 17.8 0.0 0.01 16.1 0.0 1.9 1 0 0 1 1 1 1 Tyrosine phosphatase family TMEM61 PF15105.1 KOG96697.1 - 0.053 13.0 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 TMEM61 protein family DSPc PF00782.15 KOG96697.1 - 0.056 13.0 0.0 0.21 11.1 0.0 2.0 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain NADH_u_ox_C PF12853.2 KOG96697.1 - 0.46 10.2 3.2 0.94 9.2 0.1 2.7 3 0 0 3 3 3 0 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit NAPRTase PF04095.11 KOG96698.1 - 4.1e-74 248.9 0.1 6.2e-74 248.3 0.0 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family RNA_pol_N PF01194.12 KOG96699.1 - 2e-29 101.3 0.4 2.2e-29 101.2 0.3 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.7 KOG96699.1 - 0.043 13.9 0.2 0.054 13.5 0.1 1.3 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) YhfH PF14149.1 KOG96699.1 - 0.071 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 YhfH-like protein Dynamin_N PF00350.18 KOG96700.1 - 1.5e-41 142.0 0.2 1.5e-41 142.0 0.1 2.1 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.18 KOG96700.1 - 0.00011 22.1 0.2 0.0025 17.7 0.1 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KOG96700.1 - 0.00044 20.7 0.0 0.0016 18.9 0.0 2.1 1 0 0 1 1 1 1 Miro-like protein Dynamin_M PF01031.15 KOG96700.1 - 0.0038 16.0 3.5 0.065 12.0 0.0 3.2 3 0 0 3 3 3 1 Dynamin central region AAA_16 PF13191.1 KOG96700.1 - 0.095 12.6 0.1 0.31 11.0 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain NOA36 PF06524.7 KOG96700.1 - 2 7.5 8.2 3.7 6.7 5.7 1.3 1 0 0 1 1 1 0 NOA36 protein Bd3614_N PF14442.1 KOG96700.1 - 2.9 7.8 7.4 5.6 6.9 5.2 1.4 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal WD40 PF00400.27 KOG96701.1 - 1.9e-40 135.3 18.8 6.4e-08 32.1 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Med9 PF07544.8 KOG96701.1 - 0.0079 15.9 0.8 0.015 15.0 0.6 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 DUF2802 PF10975.3 KOG96701.1 - 0.21 11.3 1.2 0.41 10.4 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) YEATS PF03366.11 KOG96702.1 - 3.8e-22 77.7 0.0 6.9e-22 76.9 0.0 1.4 1 0 0 1 1 1 1 YEATS family YqeY PF09424.5 KOG96704.1 - 6.7e-20 71.3 5.2 9.3e-20 70.9 3.6 1.2 1 0 0 1 1 1 1 Yqey-like protein Pox_A3L PF05288.6 KOG96704.1 - 0.016 14.9 0.1 0.066 12.9 0.1 2.0 1 0 0 1 1 1 0 Poxvirus A3L Protein DUF1789 PF08748.6 KOG96704.1 - 0.053 13.6 0.4 0.19 11.8 0.0 1.8 1 1 0 2 2 2 0 Domain of unknown function (DUF1789) ParB PF08775.5 KOG96704.1 - 0.084 13.1 0.2 0.084 13.1 0.2 2.5 1 1 2 3 3 3 0 ParB family GRAB PF10375.4 KOG96705.1 - 7e-07 28.6 1.2 2.4e-06 26.9 0.8 2.0 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Filament PF00038.16 KOG96705.1 - 0.035 13.5 71.0 0.014 14.9 15.3 4.3 1 1 2 3 3 3 0 Intermediate filament protein DUF3584 PF12128.3 KOG96705.1 - 0.41 7.9 66.4 0.01 13.2 27.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) IncA PF04156.9 KOG96705.1 - 0.57 9.7 79.9 0.096 12.2 19.0 4.1 1 1 2 3 3 3 0 IncA protein Spc7 PF08317.6 KOG96705.1 - 1.1 7.7 80.4 0.025 13.2 20.9 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein COMP PF11598.3 KOG96705.1 - 3.5 7.7 10.8 0.65 10.1 1.1 3.8 3 0 0 3 3 3 0 Cartilage oligomeric matrix protein Rootletin PF15035.1 KOG96705.1 - 9.4 6.1 63.3 0.91 9.4 15.0 3.5 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion RFC1 PF08519.7 KOG96706.1 - 4.8e-60 201.8 0.2 1.2e-57 194.0 0.0 2.5 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain AAA PF00004.24 KOG96706.1 - 1.6e-12 47.7 0.0 4.2e-12 46.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.21 KOG96706.1 - 2e-09 37.4 0.0 7.8e-09 35.5 0.0 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.10 KOG96706.1 - 5.6e-07 28.6 0.1 0.00065 18.5 0.0 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 KOG96706.1 - 6.3e-07 30.2 0.1 1.3e-05 25.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOG96706.1 - 1.9e-06 28.0 0.0 1.5e-05 25.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 KOG96706.1 - 2.2e-05 23.6 0.0 4.3e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.1 KOG96706.1 - 0.00045 20.5 0.0 0.002 18.4 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOG96706.1 - 0.00071 19.6 0.4 0.0075 16.2 0.0 2.8 3 1 1 4 4 3 1 AAA ATPase domain AAA_19 PF13245.1 KOG96706.1 - 0.00091 18.9 0.0 0.0024 17.5 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 KOG96706.1 - 0.00096 19.0 0.0 0.0061 16.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 KOG96706.1 - 0.0019 18.3 0.0 0.0063 16.6 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.1 KOG96706.1 - 0.0048 16.7 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 KOG96706.1 - 0.0069 15.9 1.1 0.011 15.3 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_5 PF07728.9 KOG96706.1 - 0.035 13.8 0.0 0.72 9.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PTCB-BRCT PF12738.2 KOG96706.1 - 0.048 13.5 0.0 0.048 13.5 0.0 2.3 2 0 0 2 2 1 0 twin BRCT domain NACHT PF05729.7 KOG96706.1 - 0.065 12.8 0.0 0.3 10.7 0.0 2.1 2 0 0 2 2 2 0 NACHT domain Acyl_transf_1 PF00698.16 KOG96708.1 - 0.0053 16.1 0.0 0.14 11.4 0.0 2.2 2 0 0 2 2 2 2 Acyl transferase domain Mito_carr PF00153.22 KOG96709.1 - 8.3e-71 233.7 2.4 1.4e-26 91.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.14 KOG96709.1 - 3.2 7.8 5.9 0.69 9.9 0.1 2.6 3 2 0 3 3 3 0 Tim17/Tim22/Tim23/Pmp24 family DUF2407_C PF13373.1 KOG96710.1 - 5.2e-49 165.7 1.2 7.7e-49 165.2 0.8 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.4 KOG96710.1 - 3.5e-19 68.7 0.0 8e-19 67.6 0.0 1.6 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Acetyltransf_11 PF13720.1 KOG96710.1 - 0.036 14.2 0.1 0.091 12.9 0.0 1.7 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 RNA_pol_Rpb8 PF03870.10 KOG96711.1 - 2.1e-49 167.2 0.0 2.3e-49 167.1 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 NifU_N PF01592.11 KOG96712.1 - 1e-53 180.6 0.1 1.2e-53 180.4 0.1 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain DUF1691 PF07950.6 KOG96714.1 - 1.1e-37 128.2 1.6 6e-18 64.7 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) Sdh_cyt PF01127.17 KOG96714.1 - 1.7e-09 37.5 0.9 8.4e-05 22.3 0.8 2.2 2 0 0 2 2 2 2 Succinate dehydrogenase/Fumarate reductase transmembrane subunit WD40 PF00400.27 KOG96715.1 - 3.2e-05 23.6 4.0 0.0052 16.6 0.1 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.27 KOG96716.1 - 0.00022 21.0 8.6 0.0099 15.7 0.1 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat Pkinase PF00069.20 KOG96717.1 - 2.7e-68 229.9 0.0 3.8e-68 229.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96717.1 - 5.9e-38 130.4 0.0 1.1e-37 129.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG96717.1 - 1.2e-08 34.3 0.0 2.1e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 KOG96717.1 - 0.012 14.4 0.0 0.026 13.3 0.0 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.18 KOG96717.1 - 0.013 15.2 0.0 0.19 11.4 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 KOG96717.1 - 0.015 14.3 0.0 0.026 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GrpE PF01025.14 KOG96718.1 - 4.9e-50 169.3 7.4 6.2e-50 168.9 5.1 1.1 1 0 0 1 1 1 1 GrpE MogR_DNAbind PF12181.3 KOG96718.1 - 0.0027 17.4 1.5 0.0043 16.8 0.7 1.5 1 1 0 1 1 1 1 DNA binding domain of the motility gene repressor (MogR) RNase_E_G PF10150.4 KOG96718.1 - 0.015 14.5 2.3 0.021 14.0 1.6 1.1 1 0 0 1 1 1 0 Ribonuclease E/G family TPD52 PF04201.10 KOG96718.1 - 0.022 14.5 5.1 0.03 14.0 3.5 1.2 1 0 0 1 1 1 0 Tumour protein D52 family IncA PF04156.9 KOG96718.1 - 0.025 14.1 9.5 0.034 13.7 6.6 1.1 1 0 0 1 1 1 0 IncA protein PEARLI-4 PF05278.7 KOG96718.1 - 0.1 11.9 6.3 0.16 11.3 4.3 1.3 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) ARD PF03079.9 KOG96718.1 - 0.13 12.1 5.0 0.21 11.5 3.4 1.3 1 0 0 1 1 1 0 ARD/ARD' family Atg14 PF10186.4 KOG96718.1 - 0.14 11.0 4.0 0.21 10.5 2.8 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Baculo_helicase PF04735.7 KOG96718.1 - 0.39 8.0 3.7 0.51 7.6 2.6 1.1 1 0 0 1 1 1 0 Baculovirus DNA helicase VIT1 PF01988.14 KOG96718.1 - 0.43 10.0 4.9 0.69 9.3 3.2 1.5 1 1 1 2 2 2 0 VIT family Syntaxin PF00804.20 KOG96718.1 - 3.5 7.8 11.1 9.4 6.4 5.7 2.0 1 1 1 2 2 2 0 Syntaxin Pkinase PF00069.20 KOG96719.1 - 1.3e-64 217.8 0.0 2.1e-64 217.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96719.1 - 7.4e-39 133.3 0.0 1.1e-38 132.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG96719.1 - 5.8e-08 32.0 0.0 9.6e-08 31.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 KOG96719.1 - 0.0007 19.0 0.1 0.0015 17.8 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 KOG96719.1 - 0.0061 15.6 0.1 0.014 14.4 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG96719.1 - 0.0075 16.0 0.1 0.029 14.1 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Ribosomal_L35Ae PF01247.13 KOG96720.1 - 1.5e-14 53.5 0.2 1.6e-14 53.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae DHFR_1 PF00186.14 KOG96721.1 - 4.3e-32 110.9 0.0 9.9e-32 109.7 0.0 1.6 1 1 0 1 1 1 1 Dihydrofolate reductase Oxysterol_BP PF01237.13 KOG96722.1 - 8.1e-91 304.1 1.6 9.4e-91 303.9 1.1 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein Mur_ligase_M PF08245.7 KOG96724.1 - 1.1e-05 25.5 0.6 0.00039 20.5 0.4 2.9 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.16 KOG96724.1 - 7.1e-05 22.7 0.0 0.00019 21.3 0.0 1.7 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain TruD PF01142.13 KOG96726.1 - 3.4e-66 223.4 0.1 1.2e-62 211.7 0.0 3.6 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) MOZ_SAS PF01853.13 KOG96727.1 - 4.8e-91 303.1 1.0 7.1e-91 302.5 0.7 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 KOG96727.1 - 6.7e-22 76.9 0.6 1.4e-21 75.8 0.4 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Spc97_Spc98 PF04130.8 KOG96727.1 - 0.0094 14.3 0.0 0.016 13.5 0.0 1.4 1 0 0 1 1 1 1 Spc97 / Spc98 family Acetyltransf_1 PF00583.19 KOG96727.1 - 0.017 15.1 0.0 0.037 14.0 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family DAGAT PF03982.8 KOG96728.1 - 2e-82 276.2 2.5 6e-73 245.1 0.0 2.0 1 1 1 2 2 2 2 Diacylglycerol acyltransferase adh_short PF00106.20 KOG96729.1 - 1.5e-12 47.7 0.1 2.5e-10 40.5 0.0 2.8 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOG96729.1 - 0.00051 19.8 0.0 0.00077 19.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.5 KOG96729.1 - 0.055 12.5 0.0 8.4 5.4 0.0 2.1 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) ACT PF01842.20 KOG96730.1 - 0.16 11.5 1.2 3 7.4 0.0 2.8 3 0 0 3 3 3 0 ACT domain Kei1 PF08552.6 KOG96730.1 - 2.1 7.9 13.3 5 6.7 9.2 1.6 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Apc5 PF12862.2 KOG96731.1 - 8.8e-30 102.4 4.8 4.1e-29 100.2 1.8 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 5 RecO_C PF02565.10 KOG96731.1 - 0.14 12.0 0.4 21 4.9 0.0 2.7 3 0 0 3 3 3 0 Recombination protein O C terminal Clp1 PF06807.9 KOG96732.1 - 9e-18 64.7 0.0 1.3e-17 64.2 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 KOG96732.1 - 1e-06 28.4 0.0 1.6e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 KOG96732.1 - 0.00028 20.9 0.0 0.00076 19.5 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.1 KOG96732.1 - 0.0044 16.9 0.0 0.011 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.4 KOG96732.1 - 0.0071 15.8 0.0 0.016 14.6 0.0 1.6 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.13 KOG96732.1 - 0.026 13.9 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_17 PF13207.1 KOG96732.1 - 0.027 15.2 0.0 0.075 13.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 KOG96732.1 - 0.03 14.2 0.0 0.14 12.1 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase Miro PF08477.8 KOG96732.1 - 0.041 14.3 0.0 0.098 13.1 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein ABC_tran PF00005.22 KOG96732.1 - 0.06 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter ATP-synt_ab PF00006.20 KOG96732.1 - 0.16 11.4 0.0 0.27 10.6 0.0 1.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Rhodanese PF00581.15 KOG96733.1 - 7.6e-19 68.1 0.0 3.4e-10 40.2 0.0 2.6 1 1 2 3 3 3 2 Rhodanese-like domain DUF2962 PF11176.3 KOG96734.1 - 1.6e-48 164.2 5.8 1.8e-48 164.0 4.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2962) Acetyltransf_1 PF00583.19 KOG96735.1 - 3.5e-08 33.3 0.0 4.6e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOG96735.1 - 1.3e-06 28.4 0.0 1.8e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 KOG96735.1 - 7.2e-05 22.7 0.1 0.00011 22.1 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Vps26 PF03643.10 KOG96735.1 - 0.0039 16.0 0.0 0.0047 15.7 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Sec63 PF02889.11 KOG96736.1 - 1.5e-20 73.7 0.1 3.6e-18 65.8 0.0 2.3 1 1 0 2 2 2 2 Sec63 Brl domain DnaJ PF00226.26 KOG96736.1 - 4.2e-18 64.8 2.0 6.7e-18 64.1 0.2 2.2 2 0 0 2 2 2 1 DnaJ domain DUF2232 PF09991.4 KOG96736.1 - 0.14 11.1 0.0 0.4 9.6 0.0 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) TFR_dimer PF04253.10 KOG96738.1 - 1.5e-38 131.1 0.0 3.3e-38 130.0 0.0 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.17 KOG96738.1 - 4.5e-06 26.2 0.0 0.00026 20.6 0.0 2.5 2 0 0 2 2 2 1 PA domain Peptidase_M28 PF04389.12 KOG96738.1 - 0.0081 15.9 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 EF-hand_7 PF13499.1 KOG96739.1 - 5e-25 87.4 10.4 1.2e-14 54.1 1.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOG96739.1 - 1.8e-23 79.9 15.2 4.3e-08 31.8 0.2 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOG96739.1 - 9.5e-20 68.6 10.9 3.6e-07 29.5 0.1 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 KOG96739.1 - 1.5e-17 62.0 9.1 9.7e-06 24.7 0.0 3.7 3 1 1 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOG96739.1 - 8.4e-17 60.5 12.6 1.9e-11 43.3 0.3 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.1 KOG96739.1 - 9.7e-09 35.0 0.3 0.0012 18.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOG96739.1 - 6.7e-07 29.0 1.4 0.0031 17.2 0.1 2.4 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOG96739.1 - 0.0028 17.6 0.7 0.66 10.0 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region VCBS PF13517.1 KOG96739.1 - 0.033 14.5 0.5 0.73 10.2 0.0 2.3 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella MgtE_N PF03448.12 KOG96739.1 - 0.05 13.9 3.3 0.063 13.5 0.2 2.3 3 0 0 3 3 3 0 MgtE intracellular N domain Caleosin PF05042.8 KOG96739.1 - 0.075 12.5 0.6 0.88 9.1 0.0 2.6 1 1 1 3 3 3 0 Caleosin related protein Dockerin_1 PF00404.13 KOG96739.1 - 2.5 7.9 5.1 9.9 6.0 0.1 2.5 2 0 0 2 2 2 0 Dockerin type I repeat HIT PF01230.18 KOG96740.1 - 3.5e-23 81.9 0.1 8.1e-23 80.8 0.0 1.6 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.3 KOG96740.1 - 5.7e-14 52.3 1.5 1.2e-12 48.0 1.1 2.3 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding zf-C2H2_4 PF13894.1 KOG96740.1 - 0.017 15.3 0.9 0.065 13.5 0.6 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger AAA PF00004.24 KOG96741.1 - 3e-42 143.9 0.0 5.9e-42 142.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOG96741.1 - 1.4e-06 28.1 0.2 4.1e-05 23.3 0.1 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOG96741.1 - 1.6e-06 28.2 0.2 6.4e-05 23.0 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.9 KOG96741.1 - 3.1e-05 23.9 0.0 7e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 KOG96741.1 - 7.3e-05 22.9 0.1 0.0057 16.7 0.0 2.6 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.7 KOG96741.1 - 8.6e-05 21.6 0.0 0.00018 20.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 KOG96741.1 - 0.00016 21.3 0.1 0.00032 20.3 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 KOG96741.1 - 0.00041 21.1 0.7 0.0013 19.5 0.1 2.2 2 1 0 2 2 2 1 AAA domain UPF0079 PF02367.12 KOG96741.1 - 0.0013 18.3 0.0 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 KOG96741.1 - 0.0019 18.3 0.0 0.0042 17.2 0.0 1.6 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.8 KOG96741.1 - 0.0021 16.8 0.1 0.0037 16.0 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 KOG96741.1 - 0.0035 16.7 0.2 0.0088 15.4 0.2 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.1 KOG96741.1 - 0.0044 16.4 0.6 0.03 13.7 0.3 2.2 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.16 KOG96741.1 - 0.0053 15.9 0.2 0.01 14.9 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 KOG96741.1 - 0.0073 16.1 0.0 0.018 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOG96741.1 - 0.0082 16.4 0.1 0.05 13.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 KOG96741.1 - 0.0098 15.4 0.3 0.022 14.3 0.2 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOG96741.1 - 0.013 15.5 0.8 0.02 14.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.1 KOG96741.1 - 0.013 15.3 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain KaiC PF06745.8 KOG96741.1 - 0.022 13.8 0.2 0.11 11.5 0.0 2.2 2 0 0 2 2 2 0 KaiC PhoH PF02562.11 KOG96741.1 - 0.031 13.5 0.1 0.065 12.4 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein Zeta_toxin PF06414.7 KOG96741.1 - 0.043 12.9 1.3 0.13 11.2 0.0 2.2 3 0 0 3 3 2 0 Zeta toxin Parvo_NS1 PF01057.12 KOG96741.1 - 0.059 12.2 0.1 0.13 11.0 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF815 PF05673.8 KOG96741.1 - 0.067 12.1 0.0 0.32 9.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Arch_ATPase PF01637.13 KOG96741.1 - 0.072 12.7 0.8 3.8 7.1 0.0 3.0 2 1 1 3 3 3 0 Archaeal ATPase AAA_3 PF07726.6 KOG96741.1 - 0.077 12.5 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 KOG96741.1 - 0.086 12.4 0.1 0.33 10.6 0.0 2.0 1 1 0 1 1 1 0 NACHT domain Syntaxin_2 PF14523.1 KOG96741.1 - 0.16 12.0 3.2 0.36 10.8 2.2 1.5 1 0 0 1 1 1 0 Syntaxin-like protein AAA_11 PF13086.1 KOG96741.1 - 0.27 10.7 3.1 0.88 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 KOG96741.1 - 7.9 6.7 11.7 5.8 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain NTP_transf_3 PF12804.2 KOG96742.1 - 1.3e-05 25.3 0.0 2.4e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.7 KOG96742.1 - 0.0002 20.0 2.1 0.13 10.7 0.0 2.2 1 1 1 2 2 2 2 L-fucokinase Hexapep PF00132.19 KOG96742.1 - 0.00082 18.7 3.3 5.1 6.7 0.1 3.9 1 1 1 2 2 2 1 Bacterial transferase hexapeptide (six repeats) CTP_transf_3 PF02348.14 KOG96742.1 - 0.025 14.2 0.0 0.11 12.0 0.0 2.0 2 0 0 2 2 2 0 Cytidylyltransferase Hexapep_2 PF14602.1 KOG96742.1 - 0.073 12.6 2.4 0.14 11.7 0.2 2.5 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase NTP_transferase PF00483.18 KOG96742.1 - 0.075 12.3 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyl transferase MitMem_reg PF13012.1 KOG96743.1 - 3.7e-40 136.5 2.2 7.7e-40 135.5 0.7 2.1 2 1 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.16 KOG96743.1 - 1.6e-29 101.9 0.0 3.8e-29 100.7 0.0 1.6 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease ATP_bind_1 PF03029.12 KOG96744.1 - 4.5e-81 271.8 0.0 6.2e-81 271.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.1 KOG96744.1 - 6.6e-05 23.2 1.0 0.39 11.0 0.2 2.6 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 KOG96744.1 - 0.00035 21.3 2.5 0.0015 19.3 0.0 2.8 2 2 0 2 2 2 1 AAA domain AAA_10 PF12846.2 KOG96744.1 - 0.0016 17.9 0.0 0.0021 17.5 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain MMR_HSR1 PF01926.18 KOG96744.1 - 0.0028 17.5 0.0 0.014 15.3 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_19 PF13245.1 KOG96744.1 - 0.0049 16.5 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain ArgK PF03308.11 KOG96744.1 - 0.026 13.2 0.4 0.054 12.2 0.0 1.6 2 0 0 2 2 2 0 ArgK protein AAA_33 PF13671.1 KOG96744.1 - 0.042 13.7 0.0 0.081 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOG96744.1 - 0.092 12.9 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.1 KOG96744.1 - 0.15 11.6 0.0 0.39 10.2 0.0 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain TBCA PF02970.11 KOG96746.1 - 7.5e-30 102.8 10.1 9.1e-30 102.5 7.0 1.0 1 0 0 1 1 1 1 Tubulin binding cofactor A Myosin_tail_1 PF01576.14 KOG96746.1 - 0.0012 16.6 6.7 0.0013 16.5 4.6 1.0 1 0 0 1 1 1 1 Myosin tail CENP-Q PF13094.1 KOG96746.1 - 0.0018 18.3 3.0 0.0023 17.9 2.1 1.2 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Cytochrom_C_2 PF01322.15 KOG96746.1 - 0.037 14.5 0.3 0.044 14.3 0.2 1.1 1 0 0 1 1 1 0 Cytochrome C' IncA PF04156.9 KOG96746.1 - 0.042 13.4 7.8 0.052 13.1 5.4 1.1 1 0 0 1 1 1 0 IncA protein DUF3384 PF11864.3 KOG96746.1 - 0.063 11.7 0.6 0.068 11.6 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3384) DUF2990 PF11693.3 KOG96746.1 - 0.097 12.5 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2990) Med9 PF07544.8 KOG96746.1 - 0.11 12.2 3.9 9.5 6.0 0.0 2.4 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF3010 PF11215.3 KOG96746.1 - 0.14 12.1 1.2 0.32 10.9 0.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3010) DUF342 PF03961.8 KOG96746.1 - 0.55 8.5 4.4 0.6 8.4 3.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF848 PF05852.6 KOG96746.1 - 1 9.1 5.2 1.7 8.4 3.6 1.4 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Pkinase PF00069.20 KOG96748.1 - 2.2e-57 194.1 2.7 3.3e-54 183.7 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96748.1 - 2.2e-19 69.5 0.0 8.1e-19 67.6 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase WD40 PF00400.27 KOG96750.1 - 1.2e-39 132.7 17.4 2.3e-08 33.5 0.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 KOG96750.1 - 0.00037 18.7 4.3 0.13 10.3 0.1 3.0 3 0 0 3 3 3 2 Nucleoporin Nup120/160 DivIC PF04977.10 KOG96750.1 - 0.018 14.5 0.1 0.036 13.5 0.1 1.5 1 0 0 1 1 1 0 Septum formation initiator MbeD_MobD PF04899.7 KOG96750.1 - 0.055 13.3 1.5 0.088 12.7 0.1 2.0 2 0 0 2 2 2 0 MbeD/MobD like PQQ_3 PF13570.1 KOG96750.1 - 0.064 13.5 0.1 1.3 9.3 0.0 3.0 3 0 0 3 3 3 0 PQQ-like domain bZIP_1 PF00170.16 KOG96750.1 - 0.22 11.5 0.1 0.37 10.7 0.0 1.3 1 0 0 1 1 1 0 bZIP transcription factor V_ATPase_I PF01496.14 KOG96751.1 - 0 1023.8 6.4 0 1023.6 4.4 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Mtc PF03820.12 KOG96752.1 - 1.1e-131 438.0 0.0 1.3e-131 437.8 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier Polysacc_synt_C PF14667.1 KOG96752.1 - 0.97 9.2 6.8 0.18 11.6 1.9 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain WD40 PF00400.27 KOG96753.1 - 3.3e-38 128.2 12.9 2.1e-08 33.7 0.1 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat NLE PF08154.7 KOG96753.1 - 2.4e-26 91.5 0.1 4.3e-26 90.7 0.1 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.3 KOG96753.1 - 6.5e-07 27.8 6.9 0.0047 15.1 0.3 3.6 2 2 1 3 3 3 3 Nucleoporin Nup120/160 MFS_1 PF07690.11 KOG96754.1 - 1.4e-25 89.7 32.1 1.4e-25 89.7 22.2 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOG96754.1 - 1.9e-07 30.0 9.2 1.1e-06 27.5 2.0 3.3 2 1 2 4 4 4 2 Sugar (and other) transporter Ribosomal_L28 PF00830.14 KOG96754.1 - 4.2 7.2 7.1 2.7 7.8 1.0 2.4 2 0 0 2 2 2 0 Ribosomal L28 family IPPT PF01715.12 KOG96755.1 - 1.5e-93 312.4 0.4 2e-93 312.0 0.2 1.1 1 0 0 1 1 1 1 IPP transferase AAA_17 PF13207.1 KOG96755.1 - 8.6e-07 29.8 0.3 2.9e-06 28.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOG96755.1 - 2e-06 28.1 0.1 4.3e-05 23.8 0.0 3.0 2 1 0 2 2 2 1 AAA domain IPT PF01745.11 KOG96755.1 - 1.5e-05 24.3 0.1 0.00011 21.4 0.0 2.3 2 0 0 2 2 2 1 Isopentenyl transferase AAA_33 PF13671.1 KOG96755.1 - 0.0012 18.7 0.0 0.0062 16.4 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOG96755.1 - 0.0031 17.6 0.1 0.19 11.9 0.0 2.8 2 1 0 3 3 3 1 AAA domain Zeta_toxin PF06414.7 KOG96755.1 - 0.0033 16.5 0.1 0.0089 15.1 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin RNA_helicase PF00910.17 KOG96755.1 - 0.008 16.3 0.0 0.081 13.1 0.0 2.4 2 0 0 2 2 2 1 RNA helicase DUF258 PF03193.11 KOG96755.1 - 0.014 14.5 0.0 0.025 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SKI PF01202.17 KOG96755.1 - 0.031 14.1 0.3 3.4 7.5 0.0 3.0 3 1 0 3 3 3 0 Shikimate kinase AAA_14 PF13173.1 KOG96755.1 - 0.058 13.2 0.2 0.14 12.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 KOG96755.1 - 0.06 12.7 0.1 0.19 11.1 0.1 1.8 1 0 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.7 KOG96755.1 - 0.076 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain T2SE PF00437.15 KOG96755.1 - 0.11 11.3 0.2 0.19 10.6 0.2 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein CbiA PF01656.18 KOG96755.1 - 0.14 11.5 0.6 0.51 9.7 0.3 2.0 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF1062 PF06353.7 KOG96755.1 - 0.91 9.7 4.1 7.4 6.7 0.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1062) BRO1 PF03097.13 KOG96756.1 - 3.2e-98 328.9 7.8 8.2e-98 327.5 5.4 1.7 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 KOG96756.1 - 4.8e-36 124.2 17.7 3.4e-34 118.1 12.3 2.4 1 1 0 1 1 1 1 ALIX V-shaped domain binding to HIV Porin_OmpG PF09381.5 KOG96756.1 - 0.012 14.6 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 Outer membrane protein G (OmpG) HEM4 PF02602.10 KOG96758.1 - 7.5e-40 136.5 0.0 8.5e-40 136.4 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Nucleo_P87 PF07267.6 KOG96759.1 - 0.43 9.2 3.9 0.58 8.7 2.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FSH1 PF03959.8 KOG96760.1 - 7.6e-67 224.8 0.0 9.7e-67 224.4 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 KOG96760.1 - 4.2e-07 29.8 0.0 5.6e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 KOG96760.1 - 0.00099 18.6 0.0 0.0024 17.3 0.0 1.7 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S15 PF02129.13 KOG96760.1 - 0.0017 17.7 0.0 0.0032 16.9 0.0 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.2 KOG96760.1 - 0.016 15.1 0.1 0.042 13.7 0.0 1.8 1 1 1 2 2 2 0 Alpha/beta hydrolase family Phosducin PF02114.11 KOG96761.1 - 1.8e-08 33.4 2.8 0.0004 19.2 0.0 2.1 2 0 0 2 2 2 2 Phosducin APG6 PF04111.7 KOG96761.1 - 0.02 13.9 1.1 0.031 13.3 0.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 His_Phos_1 PF00300.17 KOG96762.1 - 1.9e-34 119.0 0.2 2.3e-34 118.7 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF3530 PF12048.3 KOG96762.1 - 0.04 12.9 0.0 0.052 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Herpes_US9 PF06072.6 KOG96762.1 - 0.097 12.5 0.1 1.2 9.0 0.0 2.4 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 Rhodanese PF00581.15 KOG96764.1 - 2.7e-20 72.8 0.0 3.4e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Rhodanese PF00581.15 KOG96765.1 - 4.2e-11 43.1 0.0 5.3e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain DUF947 PF06102.7 KOG96766.1 - 3.2e-45 153.9 26.0 3.2e-45 153.9 18.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF947) DIX PF00778.12 KOG96766.1 - 2.4 7.9 7.4 2 8.2 0.3 3.0 3 1 0 3 3 3 0 DIX domain Thioredoxin PF00085.15 KOG96767.1 - 2e-25 88.4 0.4 1e-24 86.2 0.1 2.2 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.1 KOG96767.1 - 9.1e-07 28.8 0.7 0.00055 19.7 0.0 3.1 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOG96767.1 - 7.4e-06 26.0 0.2 0.00071 19.6 0.0 3.1 2 2 1 3 3 3 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KOG96767.1 - 6.3e-05 23.1 0.6 0.00019 21.5 0.1 2.0 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 KOG96767.1 - 0.0029 17.5 0.1 0.0073 16.3 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_3 PF13192.1 KOG96767.1 - 0.0034 17.1 0.0 0.007 16.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin domain AhpC-TSA PF00578.16 KOG96767.1 - 0.016 14.8 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family HTH_24 PF13412.1 KOG96767.1 - 0.075 12.4 0.0 12 5.3 0.0 2.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding AMMECR1 PF01871.12 KOG96768.1 - 3.8e-33 114.0 0.0 4.7e-33 113.7 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 SNF2_N PF00176.18 KOG96769.1 - 2e-84 282.9 0.4 4.5e-84 281.7 0.2 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOG96769.1 - 6.1e-18 64.4 0.2 1.2e-16 60.2 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SnAC PF14619.1 KOG96769.1 - 8.5e-15 54.6 4.2 8.5e-15 54.6 2.9 3.1 2 0 0 2 2 2 1 Snf2-ATP coupling, chromatin remodelling complex Bromodomain PF00439.20 KOG96769.1 - 1.5e-14 53.6 0.3 4.7e-14 52.0 0.2 1.9 1 0 0 1 1 1 1 Bromodomain QLQ PF08880.6 KOG96769.1 - 8.7e-11 41.0 0.2 8.7e-11 41.0 0.2 2.6 2 0 0 2 2 2 1 QLQ HSA PF07529.8 KOG96769.1 - 2.5 7.9 18.4 0.034 13.9 5.9 3.1 2 0 0 2 2 2 0 HSA P5-ATPase PF12409.3 KOG96770.1 - 3.1e-38 130.2 0.1 3.1e-38 130.2 0.0 2.2 2 0 0 2 2 2 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.15 KOG96770.1 - 9.1e-27 93.5 0.0 2e-26 92.4 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 KOG96770.1 - 2.2e-25 89.9 0.0 5.8e-25 88.5 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOG96770.1 - 2e-17 64.3 0.0 7.2e-16 59.2 0.0 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOG96770.1 - 2.9e-06 27.1 0.0 7e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 KOG96770.1 - 0.003 17.1 0.1 0.89 9.0 0.0 2.9 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 KOG96770.1 - 0.021 14.3 0.0 0.046 13.1 0.0 1.6 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Mpv17_PMP22 PF04117.7 KOG96771.1 - 2.9e-19 68.4 0.9 2.9e-19 68.4 0.6 2.7 2 0 0 2 2 2 1 Mpv17 / PMP22 family S10_plectin PF03501.10 KOG96772.1 - 4.4e-43 145.0 0.8 5e-43 144.8 0.5 1.0 1 0 0 1 1 1 1 Plectin/S10 domain DUF505 PF04458.7 KOG96772.1 - 0.017 13.3 0.4 0.019 13.1 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF505) YjcQ PF09639.5 KOG96772.1 - 0.022 14.8 0.4 0.035 14.1 0.3 1.4 1 0 0 1 1 1 0 YjcQ protein HTH_45 PF14947.1 KOG96772.1 - 0.03 14.1 0.8 0.049 13.4 0.2 1.6 2 0 0 2 2 2 0 Winged helix-turn-helix tRNA-synt_1c_C PF03950.13 KOG96772.1 - 0.066 12.8 0.1 0.073 12.7 0.1 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), anti-codon binding domain DUF1975 PF09318.5 KOG96772.1 - 0.067 12.7 1.9 0.084 12.4 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1975) PadR PF03551.9 KOG96772.1 - 0.63 9.8 6.1 0.093 12.5 1.5 1.8 2 1 0 2 2 2 0 Transcriptional regulator PadR-like family RRS1 PF04939.7 KOG96773.1 - 4.6e-63 211.5 6.6 5.3e-63 211.3 4.6 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) SWIB PF02201.13 KOG96774.1 - 2.4e-26 91.2 0.1 5.7e-26 90.0 0.0 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain RhoGEF PF00621.15 KOG96774.1 - 0.0042 16.9 1.5 0.0074 16.1 0.1 1.9 2 0 0 2 2 2 1 RhoGEF domain DEK_C PF08766.6 KOG96774.1 - 0.0049 16.6 1.3 0.0049 16.6 0.9 2.3 3 0 0 3 3 3 1 DEK C terminal domain Spore_coat_CotO PF14153.1 KOG96774.1 - 0.64 9.4 9.0 0.073 12.5 2.7 1.9 2 0 0 2 2 2 0 Spore coat protein CotO DUF2890 PF11081.3 KOG96774.1 - 0.84 9.6 12.0 0.12 12.4 5.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) FAM176 PF14851.1 KOG96774.1 - 8.7 6.0 9.3 0.52 9.9 2.1 1.9 2 0 0 2 2 2 0 FAM176 family Membr_traf_MHD PF10540.4 KOG96775.1 - 1.3e-11 44.4 0.4 7.5e-11 41.9 0.0 2.5 2 0 0 2 2 2 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.25 KOG96775.1 - 7.8e-11 41.6 0.3 3.5e-10 39.5 0.0 2.4 2 0 0 2 2 2 1 C2 domain LUC7 PF03194.10 KOG96775.1 - 0.057 12.9 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 LUC7 N_terminus CybS PF05328.7 KOG96776.1 - 5.2e-44 149.0 0.0 6.7e-44 148.7 0.0 1.1 1 0 0 1 1 1 1 CybS DUF898 PF05987.8 KOG96776.1 - 0.11 11.3 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Acyltransferase PF01553.16 KOG96777.1 - 0.0029 17.0 0.1 0.035 13.5 0.0 2.7 1 1 1 2 2 2 1 Acyltransferase MBF1 PF08523.5 KOG96778.1 - 4.5e-27 93.8 0.8 4.5e-27 93.8 0.6 2.1 3 0 0 3 3 3 1 Multiprotein bridging factor 1 HTH_3 PF01381.17 KOG96778.1 - 5.2e-13 48.6 0.3 8.2e-13 47.9 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.1 KOG96778.1 - 4.6e-05 23.5 0.0 8.6e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.2 KOG96778.1 - 9.6e-05 22.3 0.2 0.00018 21.4 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain ChAPs PF09295.5 KOG96779.1 - 7.2e-171 568.2 1.8 9.1e-171 567.9 1.3 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_8 PF13181.1 KOG96779.1 - 0.00083 18.9 1.1 0.53 10.1 0.0 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOG96779.1 - 0.0044 16.6 1.5 1.3 8.7 0.4 3.1 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 KOG96779.1 - 0.011 15.6 1.8 0.72 9.9 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Apc3 PF12895.2 KOG96779.1 - 0.046 13.8 1.1 1.6 8.9 0.0 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 RGS PF00615.14 KOG96780.1 - 0.0001 22.3 0.1 0.0015 18.6 0.0 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF872 PF05915.7 KOG96780.1 - 0.13 12.1 0.2 0.46 10.3 0.0 1.9 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) PrgI PF12666.2 KOG96780.1 - 3.2 7.9 5.0 1.7 8.8 0.9 2.4 3 0 0 3 3 3 0 PrgI family protein Leader_CPA1 PF08252.6 KOG96781.1 - 2.5e-17 61.6 7.6 2.6e-17 61.5 5.3 1.0 1 0 0 1 1 1 1 arg-2/CPA1 leader peptide GATase PF00117.23 KOG96782.1 - 2.2e-47 161.0 0.0 3.1e-47 160.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.17 KOG96782.1 - 1.4e-44 150.7 0.0 2.3e-44 150.0 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.8 KOG96782.1 - 1.3e-06 28.0 0.1 1.9e-05 24.1 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.19 KOG96782.1 - 0.0033 16.8 0.0 0.006 16.0 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family SNF2_N PF00176.18 KOG96783.1 - 5.9e-81 271.5 0.6 1.1e-80 270.6 0.4 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 KOG96783.1 - 1.2e-43 147.5 2.5 1.2e-43 147.5 1.7 3.1 3 0 0 3 3 3 1 SLIDE HAND PF09110.6 KOG96783.1 - 3.6e-38 130.4 5.9 3.6e-38 130.4 4.1 3.2 3 0 0 3 3 3 1 HAND Helicase_C PF00271.26 KOG96783.1 - 8.6e-17 60.7 0.0 4e-16 58.6 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOG96783.1 - 3.3e-08 33.5 0.0 3.3e-08 33.5 0.0 4.3 3 2 1 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.24 KOG96783.1 - 2e-06 27.4 0.2 5.1e-06 26.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KOG96783.1 - 0.00095 19.3 0.0 0.0065 16.6 0.0 2.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KOG96783.1 - 0.02 14.7 0.8 0.23 11.3 0.0 3.0 2 0 0 2 2 2 0 AAA domain PTRF_SDPR PF15237.1 KOG96784.1 - 0.024 14.0 1.0 0.027 13.8 0.4 1.3 1 1 0 1 1 1 0 PTRF/SDPR family Med11 PF10280.4 KOG96784.1 - 0.035 14.1 0.4 0.039 13.9 0.3 1.2 1 0 0 1 1 1 0 Mediator complex protein Phage_Mu_Gam PF07352.7 KOG96784.1 - 0.064 12.7 0.4 0.098 12.1 0.3 1.4 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Baculo_PEP_C PF04513.7 KOG96784.1 - 0.07 12.9 0.5 0.072 12.9 0.3 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus BLOC1_2 PF10046.4 KOG96784.1 - 0.082 13.0 1.4 0.085 12.9 1.0 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RL11D PF11088.3 KOG96784.1 - 0.094 12.5 0.0 0.1 12.4 0.0 1.1 1 0 0 1 1 1 0 Glycoprotein encoding membrane proteins RL5A and RL6 AHH PF14412.1 KOG96784.1 - 0.24 11.3 0.9 0.3 11.1 0.6 1.3 1 1 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH DUF2034 PF10356.4 KOG96785.1 - 1.1e-62 210.4 0.1 1.3e-62 210.2 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.7 KOG96785.1 - 0.0017 18.1 0.0 1.2 8.9 0.0 2.4 2 1 0 2 2 2 2 Restriction endonuclease MFS_1 PF07690.11 KOG96786.1 - 4e-32 111.2 43.2 2.1e-24 85.8 18.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOG96786.1 - 2.5e-12 45.9 9.7 2.5e-12 45.9 6.8 2.6 1 1 1 2 2 2 1 MFS/sugar transport protein Sugar_tr PF00083.19 KOG96786.1 - 7.1e-11 41.3 31.9 1.6e-07 30.2 7.0 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter TPT PF03151.11 KOG96787.1 - 3.4e-22 78.7 9.5 3.4e-22 78.7 6.6 2.6 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOG96787.1 - 0.00031 20.7 29.8 0.0009 19.2 4.9 4.0 3 1 1 4 4 4 3 EamA-like transporter family PIRT PF15099.1 KOG96787.1 - 0.53 9.5 3.2 6.2 6.0 1.3 2.3 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family SART-1 PF03343.8 KOG96788.1 - 9.4e-74 248.8 56.1 1.3e-70 238.4 38.9 3.7 1 1 0 1 1 1 1 SART-1 family Nop PF01798.13 KOG96789.1 - 3.8e-59 198.3 1.0 1.6e-58 196.3 0.7 2.1 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 KOG96789.1 - 2.3e-27 94.5 0.1 6.7e-27 93.0 0.0 1.9 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 KOG96789.1 - 1.1e-18 67.1 1.7 1.1e-18 67.1 1.2 3.2 2 1 0 2 2 2 1 NOP5NT (NUC127) domain GAGA_bind PF06217.7 KOG96789.1 - 0.67 9.8 22.2 1.6 8.6 15.4 1.6 1 0 0 1 1 1 0 GAGA binding protein-like family CTP_transf_1 PF01148.15 KOG96790.1 - 1e-23 84.3 10.3 3.3e-19 69.5 2.5 2.1 1 1 1 2 2 2 2 Cytidylyltransferase family Ribosomal_L18ae PF01775.12 KOG96791.1 - 2.3e-56 189.0 1.8 3.2e-56 188.5 1.2 1.2 1 0 0 1 1 1 1 Ribosomal L18ae/LX protein domain TFIIB PF00382.14 KOG96791.1 - 0.21 11.4 1.6 15 5.4 0.0 3.0 4 0 0 4 4 4 0 Transcription factor TFIIB repeat Mvb12 PF09452.5 KOG96792.1 - 0.11 12.7 0.7 1.2 9.3 0.0 2.5 2 0 0 2 2 2 0 ESCRT-I subunit Mvb12 Cation_efflux PF01545.16 KOG96794.1 - 3.2e-77 259.4 6.9 3.8e-77 259.1 4.8 1.1 1 0 0 1 1 1 1 Cation efflux family AMP-binding PF00501.23 KOG96795.1 - 5.3e-81 272.1 0.0 7.3e-81 271.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 KOG96795.1 - 0.07 14.0 0.0 0.14 13.0 0.0 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain RRM_1 PF00076.17 KOG96796.1 - 6.6e-28 96.1 1.6 5.2e-16 58.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG96796.1 - 2.1e-20 72.4 0.1 2e-11 43.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96796.1 - 1.1e-14 54.0 2.1 7.4e-07 28.9 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 KOG96796.1 - 0.00037 20.1 0.1 0.15 11.8 0.0 2.3 2 0 0 2 2 2 2 Limkain b1 Transposase_24 PF03004.9 KOG96796.1 - 0.0018 18.2 0.0 0.005 16.7 0.0 1.6 1 1 1 2 2 2 1 Plant transposase (Ptta/En/Spm family) SET_assoc PF11767.3 KOG96796.1 - 0.095 12.0 0.3 13 5.1 0.0 2.4 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Glyco_transf_8 PF01501.15 KOG96797.1 - 0.00053 19.3 7.5 0.0017 17.7 4.2 2.6 2 1 0 2 2 2 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 KOG96797.1 - 0.054 12.8 5.2 0.01 15.2 1.0 1.9 2 1 0 2 2 2 0 Mannosyltransferase putative PMT PF02366.13 KOG96798.1 - 5.3e-92 307.6 22.7 5.3e-92 307.6 15.8 1.8 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 KOG96798.1 - 3.4e-25 88.7 0.0 6.2e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 MIR domain LDB19 PF13002.2 KOG96799.1 - 1.6e-98 327.7 0.9 2.6e-98 327.1 0.6 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.24 KOG96799.1 - 1.6e-06 27.9 0.3 4.8e-06 26.4 0.1 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Aldedh PF00171.17 KOG96800.1 - 5.5e-15 54.6 1.1 4e-10 38.6 0.1 2.2 1 1 1 2 2 2 2 Aldehyde dehydrogenase family URO-D PF01208.12 KOG96800.1 - 0.0014 17.5 0.0 0.0025 16.8 0.0 1.4 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Hph PF13694.1 KOG96801.1 - 4.4e-43 147.5 7.4 4.4e-43 147.5 5.1 2.7 2 0 0 2 2 2 1 Sec63/Sec62 complex-interacting family FliJ PF02050.11 KOG96801.1 - 0.011 15.8 1.3 0.035 14.1 0.4 2.2 1 1 1 2 2 2 0 Flagellar FliJ protein DUF3671 PF12420.3 KOG96801.1 - 0.058 13.3 2.3 0.13 12.2 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function Med15_fungi PF05397.7 KOG96801.1 - 0.068 13.1 0.4 0.068 13.1 0.3 1.9 2 0 0 2 2 2 0 Mediator complex subunit 15 DUF4484 PF14831.1 KOG96801.1 - 0.077 13.0 3.3 0.18 11.9 2.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) IncA PF04156.9 KOG96801.1 - 0.57 9.7 10.1 1.5 8.4 4.7 2.3 1 1 1 2 2 2 0 IncA protein Myosin_head PF00063.16 KOG96802.1 - 1e-265 883.1 13.6 1e-265 883.1 9.5 2.3 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.14 KOG96802.1 - 1.2e-34 118.3 1.1 1.2e-34 118.3 0.8 2.9 2 0 0 2 2 2 1 DIL domain AAA_22 PF13401.1 KOG96802.1 - 0.0002 21.5 2.5 0.00049 20.2 0.0 3.0 2 0 0 2 2 2 1 AAA domain Myosin_N PF02736.14 KOG96802.1 - 0.007 16.0 0.4 0.016 14.8 0.3 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.22 KOG96802.1 - 0.021 14.4 20.4 0.27 10.9 0.0 5.9 7 0 0 7 7 7 0 IQ calmodulin-binding motif AAA_19 PF13245.1 KOG96802.1 - 0.1 12.3 0.0 0.31 10.8 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain Reo_sigmaC PF04582.7 KOG96802.1 - 1.3 8.1 11.7 0.15 11.2 3.3 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Synaptobrevin PF00957.16 KOG96803.1 - 4.3e-32 109.5 1.5 5e-32 109.3 1.0 1.0 1 0 0 1 1 1 1 Synaptobrevin TMEM117 PF15113.1 KOG96803.1 - 0.022 13.3 0.3 0.027 13.0 0.2 1.0 1 0 0 1 1 1 0 TMEM117 protein family ODV-E18 PF10717.4 KOG96803.1 - 1.1 8.7 3.7 2.3 7.6 0.2 2.2 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 DUF912 PF06024.7 KOG96803.1 - 1.2 9.2 5.0 3.8 7.6 3.3 1.9 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) ABC2_membrane PF01061.19 KOG96804.1 - 3.2e-83 278.0 59.0 2.8e-42 144.2 15.3 2.7 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.7 KOG96804.1 - 2.4e-40 136.3 2.2 6.1e-36 122.2 0.1 3.0 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.22 KOG96804.1 - 1.1e-36 126.1 0.0 2e-17 63.7 0.0 3.0 3 0 0 3 3 2 2 ABC transporter ABC_trans_N PF14510.1 KOG96804.1 - 1.5e-21 76.2 0.1 3.6e-21 75.0 0.1 1.7 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 KOG96804.1 - 4.7e-09 35.9 0.0 3.4e-05 23.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 KOG96804.1 - 7.2e-08 32.6 1.0 4.8e-06 26.6 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain AAA_33 PF13671.1 KOG96804.1 - 8.1e-05 22.5 0.0 0.0086 15.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOG96804.1 - 0.0001 21.9 0.2 0.1 12.3 0.0 2.5 2 0 0 2 2 2 2 Part of AAA domain DUF258 PF03193.11 KOG96804.1 - 0.00012 21.3 0.0 0.0033 16.6 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_23 PF13476.1 KOG96804.1 - 0.00013 22.3 0.1 0.042 14.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 KOG96804.1 - 0.00014 21.2 0.2 0.0028 17.1 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain cobW PF02492.14 KOG96804.1 - 0.00015 21.2 1.2 0.032 13.6 0.0 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 KOG96804.1 - 0.00075 19.8 0.0 0.015 15.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.1 KOG96804.1 - 0.0018 18.2 0.0 0.018 15.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 KOG96804.1 - 0.0022 17.6 0.1 0.73 9.4 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_28 PF13521.1 KOG96804.1 - 0.0026 17.7 0.4 0.057 13.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KOG96804.1 - 0.003 18.3 0.0 0.079 13.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.14 KOG96804.1 - 0.0059 15.8 0.0 0.56 9.3 0.0 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 KOG96804.1 - 0.0066 16.5 0.5 0.29 11.2 0.0 3.2 3 0 0 3 3 3 1 AAA domain UPF0079 PF02367.12 KOG96804.1 - 0.013 15.1 0.2 1.7 8.2 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_15 PF13175.1 KOG96804.1 - 0.014 14.4 0.1 0.11 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain NTPase_1 PF03266.10 KOG96804.1 - 0.078 12.6 0.3 13 5.4 0.0 2.7 3 0 0 3 3 2 0 NTPase MMR_HSR1 PF01926.18 KOG96804.1 - 0.12 12.2 0.1 22 5.0 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.1 KOG96804.1 - 0.15 11.6 0.3 5.2 6.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 KOG96804.1 - 0.17 11.3 0.1 9 5.6 0.1 2.3 2 0 0 2 2 2 0 AAA-like domain PduV-EutP PF10662.4 KOG96804.1 - 0.24 10.8 0.5 2.6 7.5 0.1 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Glt_symporter PF03616.9 KOG96805.1 - 4.8 5.5 3.3 13 4.1 0.0 2.1 2 0 0 2 2 2 0 Sodium/glutamate symporter DNA_pol_A PF00476.15 KOG96806.1 - 1.7e-124 415.3 0.0 2.7e-124 414.6 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A DUF3217 PF11506.3 KOG96806.1 - 0.027 14.1 0.0 0.082 12.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3217) vATP-synt_E PF01991.13 KOG96807.1 - 1.5e-64 216.9 12.3 1.8e-64 216.7 8.5 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Phlebovirus_NSM PF07246.6 KOG96807.1 - 0.025 13.7 7.2 0.036 13.2 5.0 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M UDP-g_GGTase PF06427.6 KOG96808.1 - 3.4e-09 36.3 0.7 3.9e-07 29.5 0.1 2.9 2 1 1 3 3 3 2 UDP-glucose:Glycoprotein Glucosyltransferase Fungal_trans PF04082.13 KOG96809.1 - 8.1e-38 129.7 6.8 1.6e-37 128.8 2.3 2.3 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG96809.1 - 5.2e-08 32.6 8.5 8.8e-08 31.9 5.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macoilin PF09726.4 KOG96809.1 - 0.17 10.1 2.8 0.24 9.6 2.0 1.1 1 0 0 1 1 1 0 Transmembrane protein SWIRM PF04433.12 KOG96810.1 - 3.1e-12 46.4 0.0 6.9e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain UQ_con PF00179.21 KOG96811.1 - 6.7e-49 164.9 0.1 7.6e-49 164.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 KOG96811.1 - 0.003 17.2 0.5 0.0043 16.7 0.4 1.4 1 1 0 1 1 1 1 UEV domain Prok-E2_B PF14461.1 KOG96811.1 - 0.0081 15.9 0.0 0.0098 15.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KOG96811.1 - 0.01 15.7 0.1 0.012 15.4 0.1 1.5 1 1 0 1 1 1 1 RWD domain SHS2_Rpb7-N PF03876.12 KOG96812.1 - 9.2e-14 51.3 0.0 1.9e-13 50.3 0.0 1.6 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rpb1_5 PF04998.12 KOG96813.1 - 3.1e-101 338.2 3.9 1.8e-100 335.7 0.2 3.0 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 KOG96813.1 - 3.1e-65 219.1 0.2 1.1e-64 217.4 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 KOG96813.1 - 1.1e-39 135.7 0.0 1.1e-38 132.4 0.0 2.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 KOG96813.1 - 1.3e-23 82.8 3.3 2e-23 82.1 0.0 3.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.7 KOG96813.1 - 5.6e-20 71.8 2.6 5.6e-20 71.8 1.8 4.4 3 1 0 3 3 3 1 RNA polymerase Rpb1, domain 1 HLH PF00010.21 KOG96815.1 - 5.9e-23 80.3 0.6 1.4e-22 79.0 0.1 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUP PF00674.13 KOG96816.1 - 6.2e-32 109.7 2.6 1.2e-31 108.8 1.8 1.5 1 1 0 1 1 1 1 DUP family Clathrin PF00637.15 KOG96816.1 - 0.079 12.5 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 Region in Clathrin and VPS IMS PF00817.15 KOG96817.1 - 1e-29 103.2 0.0 2.2e-29 102.2 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family BRCT PF00533.21 KOG96817.1 - 1.1e-13 51.1 3.6 3e-12 46.5 0.1 3.8 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain IMS_C PF11799.3 KOG96817.1 - 2.7e-10 40.2 0.0 6.9e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain PTCB-BRCT PF12738.2 KOG96817.1 - 1.4e-06 28.0 0.1 4.6e-06 26.3 0.0 2.0 2 0 0 2 2 2 1 twin BRCT domain DUF4414 PF14377.1 KOG96817.1 - 0.0011 18.8 2.2 0.034 14.0 1.5 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF4414) PK PF00224.16 KOG96818.1 - 2.4e-155 516.4 0.3 3.1e-155 516.0 0.2 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 KOG96818.1 - 2.8e-28 97.8 0.0 6.1e-28 96.7 0.0 1.6 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 KOG96818.1 - 0.0021 16.9 0.3 0.006 15.4 0.1 1.8 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family AA_permease PF00324.16 KOG96819.1 - 2.9e-146 487.5 37.8 3.4e-146 487.3 26.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG96819.1 - 2.1e-24 85.8 41.3 3e-24 85.3 28.6 1.1 1 0 0 1 1 1 1 Amino acid permease MNE1 PF13762.1 KOG96822.1 - 5e-30 104.4 6.5 5e-30 104.4 4.5 2.3 1 1 1 2 2 2 1 Mitochondrial splicing apparatus component Pkinase PF00069.20 KOG96823.1 - 2e-68 230.3 0.1 2.6e-68 229.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96823.1 - 4.5e-30 104.5 0.0 6.5e-30 104.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 KOG96823.1 - 3.1e-16 59.2 0.1 9.1e-16 57.7 0.0 1.9 2 0 0 2 2 2 1 FHA domain Kinase-like PF14531.1 KOG96823.1 - 2.9e-06 26.4 0.0 4.1e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG96823.1 - 0.0012 17.9 0.0 0.0029 16.6 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG96823.1 - 0.096 12.4 0.0 2.6 7.7 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family SOG2 PF10428.4 KOG96825.1 - 1.5e-133 445.7 16.6 2.6e-133 444.9 11.5 1.4 1 0 0 1 1 1 1 RAM signalling pathway protein LRR_4 PF12799.2 KOG96825.1 - 9.3e-20 69.8 20.7 3.6e-10 39.2 1.1 4.7 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOG96825.1 - 6.5e-17 61.0 14.5 1.1e-12 47.5 1.9 3.0 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 KOG96825.1 - 2.4e-12 45.0 9.7 0.055 13.5 0.1 7.0 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_7 PF13504.1 KOG96825.1 - 4.6e-07 28.9 5.9 1.6 9.2 0.0 6.3 5 0 0 5 5 5 3 Leucine rich repeat LRR_6 PF13516.1 KOG96825.1 - 0.0012 18.6 9.9 5.9 7.2 0.0 5.9 6 0 0 6 6 6 2 Leucine Rich repeat SpecificRecomb PF10136.4 KOG96825.1 - 0.0018 16.3 0.6 0.0033 15.5 0.4 1.3 1 0 0 1 1 1 1 Site-specific recombinase Syntaxin_2 PF14523.1 KOG96825.1 - 3.3 7.8 11.3 3 7.9 0.1 4.2 3 1 1 4 4 4 0 Syntaxin-like protein Homez PF11569.3 KOG96826.1 - 0.0082 15.1 0.0 0.033 13.2 0.0 2.0 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez ETF_QO PF05187.8 KOG96828.1 - 5.2e-39 132.6 0.0 9.8e-39 131.7 0.0 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase DAO PF01266.19 KOG96828.1 - 6.8e-12 44.9 1.2 2e-05 23.6 0.1 3.0 2 1 1 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOG96828.1 - 3.2e-09 36.1 2.7 0.0016 17.3 1.6 2.1 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.12 KOG96828.1 - 3.6e-07 29.5 0.0 0.00085 18.4 0.0 2.2 2 0 0 2 2 2 2 Thi4 family FAD_oxidored PF12831.2 KOG96828.1 - 1.4e-06 27.6 0.1 2.1e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 KOG96828.1 - 6.1e-06 26.1 0.1 1.6e-05 24.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 KOG96828.1 - 0.0019 18.1 0.1 0.0034 17.3 0.1 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_7 PF12838.2 KOG96828.1 - 0.0062 16.8 0.6 0.017 15.4 0.4 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain HI0933_like PF03486.9 KOG96828.1 - 0.0063 15.0 0.7 0.022 13.2 0.4 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.14 KOG96828.1 - 0.024 13.7 0.2 0.049 12.6 0.2 1.5 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.1 KOG96828.1 - 0.035 14.1 0.3 0.098 12.7 0.3 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KOG96828.1 - 0.07 12.9 0.2 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.22 KOG96828.1 - 0.095 13.1 1.5 9.3 6.7 0.2 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOG96828.1 - 0.095 11.5 0.3 0.13 11.1 0.2 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein Trp_halogenase PF04820.9 KOG96828.1 - 0.26 9.8 0.4 2 6.9 0.2 2.2 2 0 0 2 2 2 0 Tryptophan halogenase PX PF00787.19 KOG96829.1 - 4.3e-23 81.2 0.1 5.4e-23 80.9 0.1 1.1 1 0 0 1 1 1 1 PX domain CBFD_NFYB_HMF PF00808.18 KOG96830.1 - 7.9e-20 70.6 2.0 1.3e-19 70.0 1.4 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 KOG96830.1 - 3.6e-17 62.2 0.3 5.4e-17 61.6 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.5 KOG96830.1 - 0.12 12.2 1.0 0.16 11.7 0.1 1.7 2 0 0 2 2 2 0 CENP-S associating Centromere protein X SAM_2 PF07647.12 KOG96831.1 - 4.1e-09 36.1 0.1 1.1e-08 34.7 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 KOG96831.1 - 0.0035 17.5 0.1 0.0079 16.3 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Nab2 PF11517.3 KOG96831.1 - 0.05 13.6 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) PDEase_I PF00233.14 KOG96832.1 - 7.3e-67 225.5 3.5 7.9e-67 225.4 0.8 2.1 2 1 1 3 3 3 2 3'5'-cyclic nucleotide phosphodiesterase DNA_ligase_IV PF11411.3 KOG96832.1 - 0.01 15.5 0.1 0.023 14.4 0.1 1.6 1 0 0 1 1 1 0 DNA ligase IV HD PF01966.17 KOG96832.1 - 0.014 15.3 0.1 0.048 13.6 0.0 2.0 2 0 0 2 2 2 0 HD domain eIF2A PF08662.6 KOG96833.1 - 7.6e-29 100.7 2.9 1.6e-25 89.9 0.4 3.4 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.17 KOG96833.1 - 1.2e-08 34.4 0.1 2.7e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG96833.1 - 1.9e-06 27.7 0.2 6.8e-06 25.9 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96833.1 - 0.0002 21.1 0.0 0.00057 19.6 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Proteasome PF00227.21 KOG96834.1 - 1.9e-52 177.3 0.0 2.5e-52 176.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KOG96834.1 - 7.7e-12 44.3 0.9 1e-11 43.9 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature MFS_1 PF07690.11 KOG96835.1 - 3.2e-36 124.7 34.7 3.2e-36 124.7 24.0 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 KOG96835.1 - 9.1e-05 20.8 4.0 0.00016 20.0 2.8 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ESSS PF10183.4 KOG96835.1 - 3.4 8.1 5.4 1.2 9.5 0.2 2.6 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Zn_clus PF00172.13 KOG96836.1 - 2.8e-10 39.9 10.2 6.7e-10 38.7 7.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rabaptin PF03528.10 KOG96836.1 - 0.019 14.8 0.7 0.043 13.7 0.5 1.6 1 0 0 1 1 1 0 Rabaptin TRP PF06011.7 KOG96837.1 - 5.1e-126 420.7 37.0 6.4e-126 420.4 25.6 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 KOG96837.1 - 5.9e-38 130.0 0.9 9.9e-38 129.3 0.6 1.4 1 0 0 1 1 1 1 ML-like domain CH PF00307.26 KOG96838.1 - 3.1e-11 43.2 0.1 4.5e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.6 KOG96838.1 - 0.006 16.6 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 CDC24 Calponin PsaL PF02605.10 KOG96838.1 - 0.11 12.0 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit XI FerA PF08165.6 KOG96838.1 - 0.14 11.8 0.1 0.25 11.0 0.1 1.4 1 0 0 1 1 1 0 FerA (NUC095) domain Rad1 PF02144.11 KOG96839.1 - 4.9e-69 232.1 2.7 6.2e-69 231.8 1.9 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 ATP-grasp PF02222.17 KOG96839.1 - 0.15 11.4 0.0 1.6 8.0 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp domain Ribosomal_L7Ae PF01248.21 KOG96840.1 - 8.1e-23 79.7 0.3 1e-22 79.4 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF1269 PF06897.7 KOG96840.1 - 0.12 12.3 0.7 0.33 11.0 0.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1269) GDI PF00996.13 KOG96841.1 - 4.8e-58 196.5 0.0 6.7e-58 196.0 0.0 1.1 1 0 0 1 1 1 1 GDP dissociation inhibitor FAD_binding_3 PF01494.14 KOG96841.1 - 0.045 12.7 0.0 0.12 11.4 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain NAD_binding_8 PF13450.1 KOG96841.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NTR2 PF15458.1 KOG96841.1 - 0.18 10.9 2.1 0.31 10.2 1.5 1.3 1 0 0 1 1 1 0 Nineteen complex-related protein 2 UCR_Fe-S_N PF10399.4 KOG96841.1 - 0.19 10.8 0.2 0.51 9.5 0.2 1.7 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Kelch_4 PF13418.1 KOG96842.1 - 4.8e-10 39.0 6.0 0.0045 16.7 0.1 5.1 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.1 KOG96842.1 - 5.3e-08 32.6 0.2 0.46 10.5 0.0 5.1 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.1 KOG96842.1 - 1.1e-07 31.7 1.8 0.25 11.5 0.0 5.3 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.1 KOG96842.1 - 2.7e-06 27.3 1.6 0.0089 16.1 0.0 4.8 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_1 PF01344.20 KOG96842.1 - 3.3e-06 26.5 6.7 1.5 8.4 0.0 4.9 4 0 0 4 4 4 4 Kelch motif Kelch_2 PF07646.10 KOG96842.1 - 1.2e-05 24.8 5.6 0.57 10.0 0.0 5.4 5 0 0 5 5 5 2 Kelch motif LRR_4 PF12799.2 KOG96844.1 - 1.1e-15 56.8 53.3 7.5e-07 28.6 2.2 8.1 6 4 1 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOG96844.1 - 2e-10 40.2 39.5 4.8e-05 23.0 3.2 7.0 2 2 6 8 8 8 5 Leucine rich repeat LRR_9 PF14580.1 KOG96844.1 - 2.1e-06 27.4 6.2 0.01 15.4 0.2 3.7 2 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.28 KOG96844.1 - 4.1e-05 23.0 39.6 1.7 8.9 0.1 10.8 10 1 0 10 10 10 4 Leucine Rich Repeat LRR_6 PF13516.1 KOG96844.1 - 0.00033 20.4 35.8 1.5 9.1 0.1 10.0 8 2 2 10 10 10 3 Leucine Rich repeat LRR_7 PF13504.1 KOG96844.1 - 0.0018 18.1 30.7 8 7.1 0.0 10.9 11 0 0 11 11 11 1 Leucine rich repeat Aldedh PF00171.17 KOG96845.1 - 5.7e-183 608.4 0.2 6.4e-183 608.2 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 KOG96845.1 - 7.8e-06 24.8 0.0 1.8e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1487 PF07368.6 KOG96845.1 - 0.0012 18.1 0.1 0.43 9.7 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) ELFV_dehydrog PF00208.16 KOG96846.1 - 5.1e-84 281.6 3.3 6.3e-84 281.3 2.3 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 KOG96846.1 - 9.9e-47 157.7 0.0 2e-46 156.8 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.1 KOG96846.1 - 0.078 13.2 0.1 0.2 11.9 0.1 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding AATase PF07247.7 KOG96847.1 - 5.6e-182 605.5 0.0 6.4e-182 605.3 0.0 1.0 1 0 0 1 1 1 1 Alcohol acetyltransferase SDP_N PF12278.3 KOG96847.1 - 0.017 14.7 0.1 0.041 13.5 0.1 1.5 1 0 0 1 1 1 0 Sex determination protein N terminal MFS_1 PF07690.11 KOG96848.1 - 1e-52 179.0 74.1 2.4e-44 151.5 35.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily CHASE2 PF05226.6 KOG96848.1 - 0.12 11.5 0.4 0.19 10.9 0.2 1.3 1 0 0 1 1 1 0 CHASE2 domain Sugar_tr PF00083.19 KOG96848.1 - 0.2 10.2 34.9 0.13 10.7 8.4 2.4 2 0 0 2 2 2 0 Sugar (and other) transporter Fungal_trans PF04082.13 KOG96849.1 - 4e-21 75.0 0.1 6.1e-21 74.4 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG96849.1 - 3.1e-08 33.3 7.5 5.4e-08 32.6 5.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_6 PF08030.7 KOG96850.1 - 1.8e-28 99.4 0.0 2.8e-28 98.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 KOG96850.1 - 2.1e-27 95.0 0.0 3.7e-27 94.2 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 KOG96850.1 - 6.6e-22 77.9 11.6 6.6e-22 77.9 8.0 3.1 3 1 1 4 4 4 1 Ferric reductase like transmembrane component Sugar_tr PF00083.19 KOG96851.1 - 3.3e-72 243.5 29.4 3.7e-72 243.3 20.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG96851.1 - 5.4e-27 94.4 54.2 2.2e-19 69.3 21.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.11 KOG96851.1 - 0.00026 19.8 7.7 0.0045 15.7 5.3 2.4 1 1 0 1 1 1 1 BT1 family MFS_2 PF13347.1 KOG96851.1 - 0.0013 17.2 28.3 0.057 11.8 9.0 3.1 1 1 2 3 3 3 3 MFS/sugar transport protein DUF606 PF04657.8 KOG96851.1 - 0.0027 17.8 1.3 0.0027 17.8 0.9 3.7 3 1 0 3 3 3 1 Protein of unknown function, DUF606 JSRP PF15312.1 KOG96851.1 - 0.39 10.7 1.4 1.4 8.9 0.7 2.0 2 0 0 2 2 2 0 Junctional sarcoplasmic reticulum protein DUF2668 PF10873.3 KOG96851.1 - 1.9 8.6 4.6 5.6 7.1 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2668) Aldo_ket_red PF00248.16 KOG96852.1 - 5.8e-69 232.0 0.0 6.6e-69 231.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HA PF03457.9 KOG96852.1 - 0.035 14.1 0.0 7.7 6.7 0.0 2.5 2 0 0 2 2 2 0 Helicase associated domain Hist_deacetyl PF00850.14 KOG96853.1 - 8.1e-80 268.4 0.0 1.2e-79 267.8 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain PFK PF00365.15 KOG96853.1 - 0.19 10.6 0.0 2.1 7.2 0.0 2.0 2 0 0 2 2 2 0 Phosphofructokinase AAA PF00004.24 KOG96854.1 - 3.2e-59 198.8 0.0 1.2e-45 154.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 KOG96854.1 - 2.2e-05 24.4 0.0 0.00025 21.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 KOG96854.1 - 2.3e-05 25.1 0.2 0.0054 17.5 0.0 3.1 3 1 0 3 3 3 1 AAA domain AAA_25 PF13481.1 KOG96854.1 - 0.00028 20.3 0.1 0.0059 16.0 0.1 2.4 1 1 0 1 1 1 1 AAA domain Parvo_NS1 PF01057.12 KOG96854.1 - 0.00031 19.7 0.0 0.00062 18.7 0.0 1.4 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 RuvB_N PF05496.7 KOG96854.1 - 0.00058 18.9 0.0 0.0011 18.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOG96854.1 - 0.00058 20.0 0.0 0.02 15.0 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.9 KOG96854.1 - 0.0022 17.7 0.0 0.01 15.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 KOG96854.1 - 0.0024 18.0 0.0 0.011 15.8 0.0 2.3 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.12 KOG96854.1 - 0.0032 16.9 0.0 0.0065 15.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.1 KOG96854.1 - 0.0034 17.3 0.1 0.076 12.9 0.0 2.5 2 1 0 3 3 2 1 AAA ATPase domain AAA_14 PF13173.1 KOG96854.1 - 0.0075 16.1 0.0 0.024 14.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain TIP49 PF06068.8 KOG96854.1 - 0.011 14.5 0.0 0.022 13.4 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus KaiC PF06745.8 KOG96854.1 - 0.013 14.6 0.0 0.029 13.4 0.0 1.5 1 0 0 1 1 1 0 KaiC Mg_chelatase PF01078.16 KOG96854.1 - 0.021 14.0 0.1 0.044 12.9 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 KOG96854.1 - 0.022 14.5 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_18 PF13238.1 KOG96854.1 - 0.031 14.5 0.0 0.37 11.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain PhoH PF02562.11 KOG96854.1 - 0.099 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein DnaJ PF00226.26 KOG96855.1 - 2.1e-07 30.5 0.3 3.5e-07 29.8 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.8 KOG96855.1 - 0.012 15.4 0.1 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 Pam16 Osmo_CC PF08946.5 KOG96855.1 - 0.22 11.5 5.5 2.5 8.2 0.1 2.4 2 0 0 2 2 2 0 Osmosensory transporter coiled coil zf-DHHC PF01529.15 KOG96857.1 - 2.9e-31 108.2 16.4 2.9e-31 108.2 11.4 1.9 1 1 1 2 2 2 1 DHHC palmitoyltransferase FtsX PF02687.16 KOG96857.1 - 0.017 14.9 1.9 0.017 14.9 1.3 2.1 2 0 0 2 2 2 0 FtsX-like permease family PsbN PF02468.10 KOG96857.1 - 3.6 7.2 8.5 0.59 9.7 2.4 2.3 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) Syja_N PF02383.13 KOG96858.1 - 5e-92 308.0 0.1 5e-92 308.0 0.0 2.0 2 0 0 2 2 2 1 SacI homology domain CDC50 PF03381.10 KOG96859.1 - 8.6e-91 303.9 1.5 1.2e-90 303.4 1.1 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Macoilin PF09726.4 KOG96860.1 - 7.4 4.7 10.0 7.3 4.7 6.9 1.2 1 0 0 1 1 1 0 Transmembrane protein Na_Ca_ex PF01699.19 KOG96861.1 - 2.6e-28 98.3 33.0 1.4e-17 63.5 6.1 3.3 3 1 0 3 3 3 2 Sodium/calcium exchanger protein DUF307 PF03733.8 KOG96861.1 - 3.8e-15 56.0 4.8 3.8e-15 56.0 3.3 3.8 3 0 0 3 3 3 1 Domain of unknown function (DUF307) Abhydrolase_5 PF12695.2 KOG96862.1 - 1.4e-16 60.5 0.0 1.8e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOG96862.1 - 9.4e-12 45.2 0.0 2.7e-09 37.2 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOG96862.1 - 1.2e-07 31.4 0.0 0.002 17.7 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOG96862.1 - 3.8e-05 23.0 0.0 0.00087 18.5 0.0 2.3 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.8 KOG96862.1 - 0.0029 17.0 0.0 0.0043 16.5 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.3 KOG96862.1 - 0.0038 17.0 0.0 0.0065 16.3 0.0 1.4 1 0 0 1 1 1 1 Putative lysophospholipase BAAT_C PF08840.6 KOG96862.1 - 0.0052 16.5 0.0 0.11 12.2 0.0 2.1 1 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.11 KOG96862.1 - 0.015 14.7 0.0 3.9 6.8 0.0 2.2 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase Sugar_tr PF00083.19 KOG96863.1 - 5.4e-112 374.6 34.5 6.4e-112 374.4 23.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG96863.1 - 2.5e-26 92.2 26.0 2e-22 79.3 13.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily WD40 PF00400.27 KOG96864.1 - 3.2e-42 140.9 8.9 2.5e-10 39.7 0.2 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 KOG96864.1 - 6.7e-06 25.9 2.0 0.028 14.1 0.1 3.2 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Apc4_WD40 PF12894.2 KOG96864.1 - 0.0011 18.4 0.0 0.37 10.3 0.0 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PDT PF00800.13 KOG96865.1 - 3.8e-57 192.7 0.2 4.7e-57 192.4 0.1 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ATP11 PF06644.6 KOG96866.1 - 3.9e-103 344.5 3.1 4.5e-103 344.3 2.1 1.0 1 0 0 1 1 1 1 ATP11 protein Myb_DNA-bind_5 PF13873.1 KOG96867.1 - 0.0027 17.5 0.6 0.0062 16.4 0.1 1.8 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 KOG96867.1 - 0.0082 16.7 0.5 0.028 15.0 0.1 2.0 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain TPR_11 PF13414.1 KOG96868.1 - 1.1e-13 50.6 5.0 1.7e-10 40.3 0.1 5.0 3 2 2 5 5 5 3 TPR repeat TPR_2 PF07719.12 KOG96868.1 - 5.1e-08 32.2 1.8 0.0094 15.8 0.1 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOG96868.1 - 5.2e-07 29.0 2.0 0.25 11.0 0.1 5.6 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOG96868.1 - 2.8e-06 27.4 0.2 4.6 8.1 0.0 5.5 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOG96868.1 - 3.3e-06 26.9 1.5 0.048 13.6 0.0 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOG96868.1 - 1.1e-05 24.8 3.8 0.11 12.3 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOG96868.1 - 8e-05 22.9 4.6 0.032 14.5 0.0 4.1 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOG96868.1 - 0.0003 21.3 0.5 0.44 11.2 0.0 4.4 3 1 2 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOG96868.1 - 0.0011 18.9 2.6 0.063 13.4 0.0 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOG96868.1 - 0.01 15.6 0.0 0.086 12.7 0.0 2.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOG96868.1 - 0.017 14.9 2.1 11 6.0 0.0 5.4 5 1 0 5 5 5 0 Tetratricopeptide repeat Apc3 PF12895.2 KOG96868.1 - 0.062 13.4 4.3 0.87 9.7 0.5 3.4 3 1 1 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.15 KOG96868.1 - 1.2 9.2 4.0 1.9 8.6 0.0 3.4 4 0 0 4 4 4 0 PPR repeat tRNA_anti-codon PF01336.20 KOG96869.1 - 1.1e-10 41.1 0.4 1.9e-10 40.4 0.3 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RPA_C PF08784.6 KOG96869.1 - 3.7e-07 30.4 0.0 2.9e-06 27.6 0.0 2.2 1 1 1 2 2 2 1 Replication protein A C terminal HTH_IclR PF09339.5 KOG96869.1 - 0.012 15.2 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF4539 PF15072.1 KOG96869.1 - 0.06 13.0 0.2 0.18 11.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4539) F-box-like PF12937.2 KOG96870.1 - 4.2e-06 26.3 0.2 1.3e-05 24.7 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 KOG96870.1 - 7.9e-06 25.3 0.6 7.9e-06 25.3 0.4 2.2 2 0 0 2 2 2 1 F-box domain zf-DNL PF05180.7 KOG96871.1 - 2.4e-30 104.0 3.8 3.6e-30 103.4 2.6 1.3 1 0 0 1 1 1 1 DNL zinc finger Elf1 PF05129.8 KOG96871.1 - 0.0051 16.4 2.1 0.0086 15.7 1.5 1.3 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.1 KOG96871.1 - 0.0077 15.8 1.9 0.52 10.0 0.0 2.5 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_5 PF13719.1 KOG96871.1 - 0.0098 15.4 1.9 0.56 9.8 0.0 2.6 2 0 0 2 2 2 1 zinc-ribbon domain DUF3113 PF11310.3 KOG96871.1 - 0.048 13.3 0.2 0.95 9.1 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3113) DUF2318 PF10080.4 KOG96871.1 - 0.06 13.1 0.5 0.1 12.3 0.4 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) zf-CSL PF05207.8 KOG96871.1 - 0.069 12.6 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 CSL zinc finger Zn_Tnp_IS1595 PF12760.2 KOG96871.1 - 1.8 8.4 5.9 12 5.8 0.5 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain TFIIS_C PF01096.13 KOG96871.1 - 2 8.0 5.8 7.5 6.2 0.6 2.0 1 1 1 2 2 2 0 Transcription factor S-II (TFIIS) Kri1_C PF12936.2 KOG96873.1 - 3.9e-29 100.4 7.6 3.9e-29 100.4 5.3 5.1 4 1 1 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.7 KOG96873.1 - 3.1e-13 49.8 28.2 3.1e-13 49.8 19.5 6.6 3 2 2 5 5 5 1 KRI1-like family Pkinase PF00069.20 KOG96874.1 - 2.9e-59 200.3 0.0 3.4e-59 200.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96874.1 - 1.7e-29 102.7 0.0 2.2e-29 102.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG96874.1 - 2.1e-05 23.6 0.0 0.00011 21.2 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 KOG96874.1 - 0.0011 18.7 0.0 0.0023 17.7 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 KOG96874.1 - 0.022 14.3 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.9 KOG96874.1 - 0.039 13.0 0.0 0.059 12.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_S11 PF00411.14 KOG96875.1 - 4.4e-06 26.8 0.1 8.5e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S11 Bax1-I PF01027.15 KOG96876.1 - 3.1e-36 124.8 20.9 7.9e-36 123.5 14.5 1.6 1 1 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 MerC PF03203.9 KOG96876.1 - 0.011 16.0 2.1 0.011 16.0 1.5 2.9 2 1 1 3 3 3 0 MerC mercury resistance protein Ras PF00071.17 KOG96877.1 - 1.2e-29 102.7 0.6 8e-25 87.0 0.6 2.5 2 1 0 2 2 2 2 Ras family Miro PF08477.8 KOG96877.1 - 7e-13 49.1 0.1 2.3e-08 34.5 0.0 2.5 1 1 0 2 2 2 2 Miro-like protein Arf PF00025.16 KOG96877.1 - 2.8e-06 26.6 1.4 3.7e-05 23.0 0.6 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOG96877.1 - 0.0024 17.0 4.1 0.065 12.3 1.4 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KOG96877.1 - 0.014 15.2 0.2 0.2 11.6 0.1 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF1947 PF09183.5 KOG96877.1 - 0.058 13.1 2.7 8.9 6.1 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1947) Ribosomal_S19e PF01090.14 KOG96878.1 - 5.9e-38 129.4 0.1 6.4e-38 129.3 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Mid2 PF04478.7 KOG96879.1 - 0.62 9.4 9.0 0.23 10.8 4.7 1.4 1 1 1 2 2 2 0 Mid2 like cell wall stress sensor C6 PF01681.12 KOG96879.1 - 0.63 10.1 10.4 0.81 9.7 7.2 1.2 1 0 0 1 1 1 0 C6 domain NTP_transf_2 PF01909.18 KOG96880.1 - 1.1e-17 64.0 1.0 3.3e-17 62.5 0.1 2.3 2 0 0 2 2 2 1 Nucleotidyltransferase domain PAP_assoc PF03828.14 KOG96880.1 - 9.6e-14 51.0 2.2 1.1e-13 50.8 0.0 2.3 2 0 0 2 2 2 1 Cid1 family poly A polymerase AXH PF08517.7 KOG96880.1 - 0.091 12.9 0.7 0.3 11.2 0.2 2.0 2 0 0 2 2 2 0 Ataxin-1 and HBP1 module (AXH) Pkinase PF00069.20 KOG96881.1 - 2.1e-64 217.1 0.0 2.1e-64 217.1 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96881.1 - 1.7e-49 168.2 0.0 3.2e-49 167.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 KOG96881.1 - 1.7e-21 76.3 0.3 1.7e-21 76.3 0.2 2.9 3 0 0 3 3 3 1 P21-Rho-binding domain PH PF00169.24 KOG96881.1 - 6.2e-11 42.4 2.1 1.1e-10 41.6 0.7 1.9 2 0 0 2 2 2 1 PH domain Kinase-like PF14531.1 KOG96881.1 - 1.4e-06 27.5 0.0 2.6e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.1 KOG96881.1 - 0.00088 19.5 0.9 0.00088 19.5 0.6 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain APH PF01636.18 KOG96881.1 - 0.051 13.2 0.0 0.051 13.2 0.0 2.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family Sec7_N PF12783.2 KOG96882.1 - 1.1e-38 132.3 4.4 1.1e-38 132.3 3.0 3.9 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Pet20 PF08692.5 KOG96883.1 - 8.3e-11 41.9 0.0 2.5e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 Mitochondrial protein Pet20 PalH PF08733.5 KOG96884.1 - 5.4e-92 308.3 16.3 7e-92 307.9 11.3 1.1 1 0 0 1 1 1 1 PalH/RIM21 Nucleoplasmin PF03066.10 KOG96884.1 - 0.002 17.6 7.9 0.0035 16.8 5.5 1.3 1 0 0 1 1 1 1 Nucleoplasmin DUF2457 PF10446.4 KOG96884.1 - 0.085 11.5 11.7 0.14 10.9 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.7 KOG96884.1 - 0.13 11.4 11.0 0.19 10.9 7.6 1.2 1 0 0 1 1 1 0 NOA36 protein Retinal PF15449.1 KOG96884.1 - 0.18 9.3 3.7 0.24 9.0 2.6 1.1 1 0 0 1 1 1 0 Retinal protein CENP-B_dimeris PF09026.5 KOG96884.1 - 0.6 10.3 15.3 1.6 9.0 10.6 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RabGAP-TBC PF00566.13 KOG96885.1 - 5.2e-44 150.2 7.1 8.6e-43 146.2 4.9 2.3 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DUF2457 PF10446.4 KOG96885.1 - 0.14 10.8 15.0 0.23 10.1 10.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nucleoplasmin PF03066.10 KOG96885.1 - 4.1 6.8 10.0 9.4 5.7 6.9 1.5 1 0 0 1 1 1 0 Nucleoplasmin TruB_N PF01509.13 KOG96886.1 - 1e-40 139.2 0.6 7.4e-39 133.2 0.0 2.7 3 0 0 3 3 3 2 TruB family pseudouridylate synthase (N terminal domain) Mid1 PF12929.2 KOG96887.1 - 1.2e-135 452.6 20.7 1.6e-135 452.2 14.3 1.2 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component AAA PF00004.24 KOG96888.1 - 1.9e-18 66.9 0.0 8.8e-18 64.7 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 KOG96888.1 - 7.8e-17 61.3 0.0 9.9e-15 54.5 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.6 KOG96888.1 - 9e-14 51.2 0.0 1.9e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.10 KOG96888.1 - 2e-07 30.0 0.0 1.1e-06 27.5 0.0 2.0 1 1 0 2 2 2 1 Rad17 cell cycle checkpoint protein RuvB_N PF05496.7 KOG96888.1 - 5e-07 29.0 0.0 9.6e-07 28.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOG96888.1 - 7.1e-07 29.4 1.2 0.045 13.8 0.1 2.8 2 1 1 3 3 2 2 AAA domain DNA_pol3_delta PF06144.8 KOG96888.1 - 1.5e-06 27.8 0.4 3.7e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_14 PF13173.1 KOG96888.1 - 2.8e-06 27.2 0.1 1.9e-05 24.5 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 KOG96888.1 - 5.3e-06 26.5 0.0 2.4e-05 24.4 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 KOG96888.1 - 1.8e-05 24.4 0.8 0.0056 16.4 0.0 3.6 3 1 1 4 4 4 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 KOG96888.1 - 5.1e-05 22.9 0.0 0.00014 21.5 0.0 1.8 1 1 0 1 1 1 1 Part of AAA domain DUF815 PF05673.8 KOG96888.1 - 5.9e-05 22.1 0.0 8.8e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_11 PF13086.1 KOG96888.1 - 8.9e-05 22.1 0.0 0.00093 18.8 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 KOG96888.1 - 0.00045 21.0 0.0 0.0011 19.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 KOG96888.1 - 0.00051 19.5 0.0 0.001 18.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein ResIII PF04851.10 KOG96888.1 - 0.00058 19.7 0.0 0.013 15.3 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_25 PF13481.1 KOG96888.1 - 0.0013 18.1 0.4 0.03 13.7 0.1 2.6 2 1 0 2 2 1 1 AAA domain AAA_18 PF13238.1 KOG96888.1 - 0.0018 18.6 0.0 0.0064 16.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 KOG96888.1 - 0.0022 17.5 0.1 0.032 13.7 0.0 2.2 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_24 PF13479.1 KOG96888.1 - 0.0042 16.6 0.0 0.0087 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 KOG96888.1 - 0.0053 16.0 0.0 2.5 7.2 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein AAA_3 PF07726.6 KOG96888.1 - 0.0059 16.2 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 KOG96888.1 - 0.0059 16.0 0.3 0.65 9.3 0.2 2.5 1 1 0 1 1 1 1 AAA-like domain TIP49 PF06068.8 KOG96888.1 - 0.006 15.3 0.0 0.047 12.4 0.0 2.1 2 0 0 2 2 2 1 TIP49 C-terminus Viral_helicase1 PF01443.13 KOG96888.1 - 0.0062 16.0 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.1 KOG96888.1 - 0.016 14.7 0.0 0.26 10.8 0.0 2.3 1 1 0 1 1 1 0 AAA domain NYD-SP12_N PF15015.1 KOG96888.1 - 0.021 13.0 0.0 0.03 12.5 0.0 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal Mg_chelatase PF01078.16 KOG96888.1 - 0.024 13.8 0.0 0.14 11.2 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Arch_ATPase PF01637.13 KOG96888.1 - 0.024 14.3 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase RNA_helicase PF00910.17 KOG96888.1 - 0.025 14.7 0.0 0.048 13.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.1 KOG96888.1 - 0.031 14.2 0.0 0.088 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 KOG96888.1 - 0.038 13.6 0.0 0.08 12.6 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 KOG96888.1 - 0.04 13.7 0.1 0.098 12.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.4 KOG96888.1 - 0.05 12.5 0.1 0.19 10.6 0.0 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Cyclin_N PF00134.18 KOG96889.1 - 7.6e-21 73.9 0.0 1.2e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 KOG96889.1 - 9.5e-12 45.5 0.0 1.7e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Cyclin Rcd1 PF04078.8 KOG96890.1 - 5.6e-120 399.0 3.3 6.7e-120 398.8 2.3 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Menin PF05053.8 KOG96890.1 - 4.6 5.3 7.7 7 4.6 5.4 1.2 1 0 0 1 1 1 0 Menin Adaptin_N PF01602.15 KOG96891.1 - 6.5e-120 400.9 14.0 7.9e-120 400.6 9.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.5 KOG96891.1 - 6.9e-48 162.2 2.0 1.5e-47 161.1 1.4 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain HEAT_2 PF13646.1 KOG96891.1 - 9.7e-11 41.8 1.5 0.0028 17.9 0.0 5.0 2 1 5 7 7 7 4 HEAT repeats HEAT PF02985.17 KOG96891.1 - 0.00035 20.3 3.8 4.9 7.5 0.0 6.5 7 1 1 8 8 8 1 HEAT repeat Cnd1 PF12717.2 KOG96891.1 - 0.049 13.4 13.8 0.11 12.2 1.3 3.8 3 2 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 KOG96891.1 - 0.058 13.9 2.0 0.44 11.1 0.1 3.5 3 1 0 3 3 3 0 HEAT-like repeat RRM_1 PF00076.17 KOG96892.1 - 1.8e-17 62.6 0.4 1.1e-07 31.3 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG96892.1 - 1.8e-13 50.2 0.1 2.5e-06 27.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96892.1 - 2.1e-10 40.3 0.5 8e-05 22.4 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Imm9 PF15561.1 KOG96892.1 - 0.027 14.0 0.1 0.07 12.7 0.1 1.7 1 0 0 1 1 1 0 Immunity protein 9 SET_assoc PF11767.3 KOG96892.1 - 0.08 12.2 0.0 1.2 8.5 0.0 2.4 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated RabGGT_insert PF07711.6 KOG96892.1 - 0.082 12.7 0.1 0.6 9.9 0.0 2.1 2 0 0 2 2 2 0 Rab geranylgeranyl transferase alpha-subunit, insert domain DUF4065 PF13274.1 KOG96892.1 - 0.41 11.3 4.2 0.14 12.8 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4065) TYA PF01021.14 KOG96893.1 - 4.3e-33 113.3 10.1 4.3e-33 113.3 7.0 2.7 3 1 0 3 3 3 1 TYA transposon protein Ribosomal_L18e PF00828.14 KOG96894.1 - 3.6e-23 82.3 0.2 1e-22 80.8 0.2 1.7 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 WSC PF01822.14 KOG96895.1 - 7.5e-12 45.0 11.5 7.5e-12 45.0 8.0 3.4 2 1 0 2 2 1 1 WSC domain SKG6 PF08693.5 KOG96895.1 - 0.0024 17.1 2.5 0.0024 17.1 1.7 3.4 5 0 0 5 5 2 1 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.10 KOG96895.1 - 0.0036 16.8 0.6 0.0073 15.8 0.4 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Glycophorin_A PF01102.13 KOG96895.1 - 0.0088 15.7 1.7 0.0088 15.7 1.2 4.5 1 1 2 3 3 1 1 Glycophorin A EphA2_TM PF14575.1 KOG96895.1 - 0.0095 16.3 0.6 0.039 14.3 0.0 2.3 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain CD34_antigen PF06365.7 KOG96895.1 - 0.018 14.7 0.0 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF3147 PF11345.3 KOG96895.1 - 0.018 15.0 0.3 0.034 14.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3147) Syndecan PF01034.15 KOG96895.1 - 0.037 13.6 0.0 0.076 12.6 0.0 1.5 1 0 0 1 1 1 0 Syndecan domain DUF912 PF06024.7 KOG96895.1 - 0.043 13.8 0.0 0.043 13.8 0.0 3.2 2 1 0 2 2 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) CbiM PF01891.11 KOG96895.1 - 0.075 12.6 0.1 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 Cobalt uptake substrate-specific transmembrane region Rifin_STEVOR PF02009.11 KOG96895.1 - 0.094 12.3 21.7 98 2.4 15.0 2.2 1 1 0 1 1 1 0 Rifin/stevor family TMEM190 PF15431.1 KOG96895.1 - 2.5 8.0 0.0 2.5 8.0 0.0 3.8 3 1 0 4 4 3 0 Transmembrane protein 190 RNase_P_pop3 PF08228.6 KOG96896.1 - 4.4e-63 211.8 0.7 5.5e-63 211.5 0.5 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 Aha1_N PF09229.6 KOG96897.1 - 2.1e-33 115.0 0.0 2.8e-33 114.6 0.0 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal ERG4_ERG24 PF01222.12 KOG96898.1 - 1.6e-186 620.0 10.9 1.9e-186 619.8 7.6 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 KOG96898.1 - 6.1e-07 28.9 0.6 1.3e-06 27.9 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) COX4_pro_2 PF07835.7 KOG96899.1 - 0.65 10.0 3.1 2.3 8.2 2.2 1.9 1 0 0 1 1 1 0 Bacterial aa3 type cytochrome c oxidase subunit IV TrbL PF04610.9 KOG96899.1 - 1.4 8.5 8.1 1.8 8.2 0.1 3.2 3 0 0 3 3 3 0 TrbL/VirB6 plasmid conjugal transfer protein PH PF00169.24 KOG96900.1 - 3.3e-11 43.3 0.4 1.9e-09 37.6 0.0 2.6 2 0 0 2 2 2 2 PH domain Abhydrolase_1 PF00561.15 KOG96901.1 - 5e-76 255.2 0.0 6.2e-76 254.9 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOG96901.1 - 1.5e-10 41.3 0.0 1.8e-09 37.8 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOG96901.1 - 0.0055 16.4 0.0 0.16 11.6 0.0 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family HCO3_cotransp PF00955.16 KOG96902.1 - 2.2e-59 201.5 15.5 1.4e-36 126.2 3.2 2.1 1 1 1 2 2 2 2 HCO3- transporter family 2-Hacid_dh_C PF02826.14 KOG96903.1 - 2.6e-56 189.6 0.0 5.5e-56 188.5 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 KOG96903.1 - 1.7e-12 46.9 0.0 2.5e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 KOG96903.1 - 0.00027 20.8 0.0 0.00072 19.4 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.7 KOG96903.1 - 0.00078 18.8 0.0 0.0019 17.5 0.0 1.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain AdoHcyase_NAD PF00670.16 KOG96903.1 - 0.0022 17.8 0.1 0.12 12.2 0.0 2.9 2 1 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Gp_dh_N PF00044.19 KOG96903.1 - 0.1 12.5 0.1 0.33 10.9 0.0 2.0 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain TIMELESS PF04821.9 KOG96904.1 - 2.3e-47 161.4 3.8 5.2e-47 160.3 0.8 2.8 2 1 0 2 2 2 1 Timeless protein Nucleoplasmin PF03066.10 KOG96904.1 - 1.3 8.5 16.1 3.4 7.1 11.1 1.8 1 0 0 1 1 1 0 Nucleoplasmin FAM176 PF14851.1 KOG96904.1 - 7.6 6.1 8.4 34 4.0 5.8 2.1 1 0 0 1 1 1 0 FAM176 family Sec2p PF06428.6 KOG96905.1 - 9e-30 102.5 6.8 9e-30 102.5 4.7 3.4 3 0 0 3 3 3 1 GDP/GTP exchange factor Sec2p Baculo_PEP_C PF04513.7 KOG96905.1 - 0.47 10.2 14.5 24 4.7 7.2 3.2 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FH2 PF02181.18 KOG96906.1 - 5.2e-87 292.1 7.2 5.2e-87 292.1 5.0 4.0 6 1 0 6 6 6 1 Formin Homology 2 Domain Drf_FH3 PF06367.11 KOG96906.1 - 1.1e-49 168.4 3.5 1.1e-49 168.4 2.4 4.4 4 0 0 4 4 4 2 Diaphanous FH3 Domain Drf_GBD PF06371.8 KOG96906.1 - 2.2e-24 85.8 0.8 2.6e-18 66.0 0.0 5.8 5 1 1 6 6 6 2 Diaphanous GTPase-binding Domain AA_permease PF00324.16 KOG96907.1 - 1.6e-50 171.8 18.8 1.7e-50 171.7 13.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG96907.1 - 2.5e-10 39.4 18.9 3.5e-10 39.0 13.1 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOG96908.1 - 9.8e-53 179.1 17.7 1.1e-52 178.9 12.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG96908.1 - 3.8e-12 45.4 18.0 4.7e-12 45.1 12.5 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4149 PF13664.1 KOG96908.1 - 0.011 15.8 4.1 0.011 15.8 2.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4149) DUF4131 PF13567.1 KOG96908.1 - 0.083 12.2 4.0 1.7 8.0 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) RhodobacterPufX PF11511.3 KOG96908.1 - 0.12 11.7 0.7 0.69 9.3 0.3 2.4 2 0 0 2 2 2 0 Intrinsic membrane protein PufX TcpE PF12648.2 KOG96908.1 - 3.2 7.9 8.3 2.1 8.5 0.8 2.6 3 0 0 3 3 3 0 TcpE family PI3_PI4_kinase PF00454.22 KOG96909.1 - 6.4e-27 94.5 0.0 1.4e-26 93.4 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.3 KOG96909.1 - 1.6e-20 72.5 4.2 5.3e-20 70.8 0.7 2.6 2 0 0 2 2 2 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.15 KOG96909.1 - 3.3e-06 26.4 0.8 8.2e-06 25.1 0.5 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Ist1 PF03398.9 KOG96910.1 - 8.3e-57 191.1 4.0 1.4e-56 190.4 2.8 1.4 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DUF4414 PF14377.1 KOG96910.1 - 0.027 14.3 2.0 0.027 14.3 1.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4414) SprA-related PF12118.3 KOG96910.1 - 2.5 7.3 10.8 0.34 10.1 1.9 2.1 2 0 0 2 2 2 0 SprA-related family CRAL_TRIO PF00650.15 KOG96911.1 - 9.3e-39 132.4 0.0 1.6e-38 131.6 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 KOG96911.1 - 1.2e-09 38.0 0.1 3.7e-09 36.5 0.1 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 KOG96911.1 - 7.4e-05 22.6 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain YIF1 PF03878.10 KOG96912.1 - 4.5e-90 300.9 7.3 6.8e-90 300.3 5.1 1.3 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.12 KOG96912.1 - 1e-06 28.3 2.5 2.1e-06 27.3 1.7 1.5 1 0 0 1 1 1 1 Yip1 domain DUF1744 PF08490.7 KOG96913.1 - 8.6e-160 531.6 13.2 1.5e-159 530.8 9.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.14 KOG96913.1 - 1.5e-72 244.2 4.6 5.2e-72 242.4 2.8 2.2 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.16 KOG96913.1 - 2.2e-22 79.5 4.1 3.2e-22 78.9 0.6 2.4 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.4 KOG96913.1 - 2.6e-07 30.3 0.3 1.3e-06 28.1 0.2 2.1 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 KOG96913.1 - 1.8e-05 24.5 2.5 6.5e-05 22.8 0.0 3.3 4 0 0 4 4 4 1 RNase_H superfamily ORC5_C PF14630.1 KOG96914.1 - 5.7e-64 216.1 0.4 8e-64 215.7 0.3 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_22 PF13401.1 KOG96914.1 - 2.8e-07 30.7 0.0 5.8e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOG96914.1 - 2.2e-06 27.7 0.0 5.9e-06 26.3 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.7 KOG96914.1 - 0.037 13.6 0.1 3.2 7.3 0.0 2.4 2 0 0 2 2 2 0 NACHT domain ResIII PF04851.10 KOG96914.1 - 0.051 13.4 0.0 0.09 12.5 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Yae1_N PF09811.4 KOG96915.1 - 6e-13 48.0 3.2 1.1e-12 47.2 2.2 1.5 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Thioredoxin_5 PF13743.1 KOG96915.1 - 0.039 13.5 0.3 0.053 13.0 0.2 1.4 1 1 0 1 1 1 0 Thioredoxin HMA PF00403.21 KOG96916.1 - 5.2e-10 39.3 0.2 6.3e-10 39.0 0.1 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain Dsl1_C PF11989.3 KOG96917.1 - 4.3e-127 423.2 16.1 4.3e-127 423.2 11.2 3.0 3 0 0 3 3 3 1 Retrograde transport protein Dsl1 C terminal Dsl1_N PF11988.3 KOG96917.1 - 6.4e-125 416.6 22.5 1.2e-124 415.8 15.6 1.4 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 N terminal BUD22 PF09073.5 KOG96917.1 - 0.053 12.5 14.9 0.12 11.3 10.3 1.5 1 0 0 1 1 1 0 BUD22 COPI_C PF06957.6 KOG96917.1 - 0.056 11.9 8.9 0.085 11.3 6.1 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus MCM_N PF14551.1 KOG96917.1 - 0.057 13.9 6.6 0.41 11.1 2.6 3.3 2 1 0 2 2 2 0 MCM N-terminal domain EamA PF00892.15 KOG96918.1 - 0.1 12.6 6.0 0.21 11.6 4.2 1.4 1 0 0 1 1 1 0 EamA-like transporter family Pterin_bind PF00809.17 KOG96919.1 - 3.5e-44 150.6 0.2 1.7e-42 145.1 0.2 2.5 1 1 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.15 KOG96919.1 - 1e-39 135.1 0.0 1.4e-38 131.4 0.0 2.3 2 0 0 2 2 2 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.13 KOG96919.1 - 1.8e-36 124.7 0.1 3.2e-17 62.6 0.0 2.5 2 0 0 2 2 2 2 Dihydroneopterin aldolase zf-CCHC PF00098.18 KOG96920.1 - 4e-52 171.7 52.7 7.1e-08 32.0 1.0 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.1 KOG96920.1 - 2.2e-10 40.0 45.4 0.0054 16.3 0.5 7.1 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.1 KOG96920.1 - 3e-06 26.8 47.1 0.1 12.3 0.2 7.0 1 1 5 6 6 6 6 Zinc knuckle zf-CCHC_2 PF13696.1 KOG96920.1 - 0.00085 18.7 42.8 0.21 11.1 0.4 7.1 4 3 3 7 7 7 6 Zinc knuckle zf-CCHC_6 PF15288.1 KOG96920.1 - 9.7 5.9 45.3 0.6 9.8 0.9 6.9 7 0 0 7 7 7 0 Zinc knuckle RTC4 PF14474.1 KOG96921.1 - 1.5e-37 128.2 0.0 3.4e-37 127.1 0.0 1.6 1 0 0 1 1 1 1 RTC4-like domain WD40 PF00400.27 KOG96922.1 - 2.7e-14 52.4 9.4 2.5e-09 36.6 0.4 6.7 8 0 0 8 8 8 2 WD domain, G-beta repeat DUF4130 PF13566.1 KOG96922.1 - 0.053 13.0 0.3 0.098 12.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4130 Hira PF07569.6 KOG96922.1 - 0.076 12.2 3.4 1.6 7.8 0.0 3.5 3 1 1 4 4 4 0 TUP1-like enhancer of split MRP-L46 PF11788.3 KOG96923.1 - 2.6e-36 124.6 0.0 4.4e-36 123.9 0.0 1.4 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 RRM_1 PF00076.17 KOG96924.1 - 1.1e-06 28.1 0.0 2.1e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG96924.1 - 1.2e-06 28.3 0.0 2.4e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96924.1 - 0.00095 18.9 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spo7_2_N PF15407.1 KOG96924.1 - 0.0014 18.0 0.0 0.0034 16.8 0.0 1.7 1 0 0 1 1 1 1 Sporulation protein family 7 CTD_bind PF04818.8 KOG96924.1 - 0.0063 16.7 0.0 0.018 15.2 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. GKAP PF03359.8 KOG96924.1 - 3.1 7.3 8.4 5.3 6.5 5.8 1.3 1 0 0 1 1 1 0 Guanylate-kinase-associated protein (GKAP) protein AAA_23 PF13476.1 KOG96925.1 - 2.9e-30 106.0 1.2 2.9e-30 106.0 0.8 8.3 1 1 4 6 6 6 1 AAA domain Rad50_zn_hook PF04423.9 KOG96925.1 - 9.2e-15 53.8 4.5 9.2e-15 53.8 3.1 5.5 4 0 0 4 4 4 1 Rad50 zinc hook motif SbcCD_C PF13558.1 KOG96925.1 - 9.2e-11 41.5 0.0 2.3e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.1 KOG96925.1 - 6.8e-08 32.8 9.5 9e-05 22.5 4.7 7.4 2 1 4 7 7 7 2 AAA domain SMC_N PF02463.14 KOG96925.1 - 1.7e-07 30.7 0.1 1.7e-07 30.7 0.1 5.0 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_13 PF13166.1 KOG96925.1 - 0.00015 20.4 0.0 0.00015 20.4 0.0 7.2 2 1 5 7 7 7 3 AAA domain AAA_29 PF13555.1 KOG96925.1 - 0.00072 19.0 0.0 0.0017 17.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain CENP-F_leu_zip PF10473.4 KOG96925.1 - 0.0058 16.4 15.8 0.0058 16.4 11.0 8.8 2 2 6 8 8 8 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_19 PF13245.1 KOG96925.1 - 0.22 11.2 0.0 0.61 9.8 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain FGGY_C PF02782.11 KOG96926.1 - 1.5e-26 93.2 0.0 2.3e-26 92.6 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 KOG96926.1 - 1.5e-08 34.2 0.0 2.8e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain RNA_pol_I_A49 PF06870.7 KOG96927.1 - 4.6e-142 473.1 0.9 5.2e-142 472.9 0.7 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor tRNA-synt_1e PF01406.14 KOG96928.1 - 2.5e-146 486.5 0.2 2.5e-146 486.5 0.2 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 KOG96928.1 - 4.9e-09 35.3 1.2 2.2e-06 26.6 0.1 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 KOG96928.1 - 7.4e-05 20.9 2.4 0.00031 18.8 0.0 2.5 3 0 0 3 3 3 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.13 KOG96928.1 - 0.00077 18.2 0.1 0.0018 16.9 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (K) DUF4105 PF13387.1 KOG96928.1 - 0.013 14.6 0.1 0.026 13.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) NAP PF00956.13 KOG96929.1 - 3.8e-20 72.0 2.5 4.7e-20 71.7 1.7 1.1 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) CWC25 PF12542.3 KOG96930.1 - 5.6e-15 55.5 1.5 5.6e-15 55.5 1.0 2.0 2 0 0 2 2 2 1 Pre-mRNA splicing factor Cir_N PF10197.4 KOG96930.1 - 1.5e-13 50.5 8.2 3e-13 49.5 5.7 1.6 1 0 0 1 1 1 1 N-terminal domain of CBF1 interacting co-repressor CIR DUF2951 PF11166.3 KOG96930.1 - 0.069 13.0 2.1 0.13 12.0 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) IncA PF04156.9 KOG96930.1 - 1.2 8.6 4.3 1.5 8.3 3.0 1.3 1 0 0 1 1 1 0 IncA protein DMAP1 PF05499.7 KOG96930.1 - 4.9 6.6 9.1 2.8 7.4 4.9 1.8 1 1 1 2 2 2 0 DNA methyltransferase 1-associated protein 1 (DMAP1) DUF972 PF06156.8 KOG96930.1 - 9.6 6.6 7.6 6 7.2 4.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF972) SUI1 PF01253.17 KOG96931.1 - 2.6e-28 97.6 0.9 3.3e-28 97.3 0.6 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF3404 PF11884.3 KOG96931.1 - 0.14 11.0 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3404) ANTH PF07651.11 KOG96932.1 - 2.7e-74 249.3 0.1 2.7e-74 249.3 0.1 2.9 3 0 0 3 3 3 1 ANTH domain I_LWEQ PF01608.12 KOG96932.1 - 1.6e-58 196.9 7.5 1.6e-58 196.9 5.2 5.3 3 2 2 5 5 5 1 I/LWEQ domain ENTH PF01417.15 KOG96932.1 - 0.0001 22.1 2.8 0.0002 21.1 0.0 2.8 2 1 0 2 2 2 1 ENTH domain ATG2_CAD PF13329.1 KOG96933.1 - 5.3e-31 107.3 1.3 5.3e-31 107.3 0.9 2.7 2 0 0 2 2 2 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.6 KOG96933.1 - 1.1e-29 102.4 0.2 2.3e-29 101.4 0.1 1.6 1 0 0 1 1 1 1 ATG C terminal domain G6PD_C PF02781.11 KOG96934.1 - 1.7e-134 447.2 0.0 2.3e-134 446.8 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.17 KOG96934.1 - 2.5e-63 213.6 0.0 2.2e-62 210.5 0.0 2.0 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Fe_hyd_lg_C PF02906.9 KOG96935.1 - 8.8e-47 159.7 0.0 1.3e-46 159.1 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Peptidase_C1_2 PF03051.10 KOG96936.1 - 5.7e-178 591.9 0.3 6.7e-178 591.7 0.2 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.18 KOG96936.1 - 2.8e-06 27.3 0.0 0.11 12.3 0.0 2.5 2 0 0 2 2 2 2 Papain family cysteine protease Peptidase_S8 PF00082.17 KOG96937.1 - 1.3e-58 198.4 1.6 1.3e-58 198.4 1.1 2.4 2 1 0 2 2 2 1 Subtilase family P_proprotein PF01483.15 KOG96937.1 - 6e-26 90.0 0.7 1.4e-25 88.8 0.5 1.7 1 0 0 1 1 1 1 Proprotein convertase P-domain DUF1049 PF06305.6 KOG96937.1 - 0.032 13.7 0.3 0.068 12.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Plasmodium_Vir PF05795.6 KOG96937.1 - 0.1 11.7 0.5 0.18 10.9 0.3 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF912 PF06024.7 KOG96937.1 - 0.18 11.8 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Ytp1 PF10355.4 KOG96938.1 - 3e-78 262.7 17.3 4.4e-78 262.2 12.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) Med16 PF11635.3 KOG96939.1 - 1.3e-224 747.5 13.2 1.6e-224 747.2 9.2 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 Globin PF00042.17 KOG96940.1 - 3.5e-05 24.1 0.1 9.8e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 Globin EXOSC1 PF10447.4 KOG96942.1 - 2.1e-34 117.3 0.1 2.9e-33 113.6 0.0 2.2 2 0 0 2 2 2 1 Exosome component EXOSC1/CSL4 CRAL_TRIO PF00650.15 KOG96943.1 - 3.8e-37 127.2 0.0 5.8e-37 126.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 KOG96943.1 - 1.9e-11 43.9 2.0 1.9e-11 43.9 1.4 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain Elongin_A PF06881.6 KOG96944.1 - 3.2e-26 91.8 13.5 1.2e-22 80.3 1.2 2.4 1 1 1 2 2 2 2 RNA polymerase II transcription factor SIII (Elongin) subunit A DapB_C PF05173.9 KOG96944.1 - 0.24 11.1 1.1 3.6 7.3 0.1 2.2 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, C-terminus GST_C PF00043.20 KOG96945.1 - 2.4e-22 78.7 0.0 5.1e-22 77.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 KOG96945.1 - 1.3e-16 60.4 0.0 2.6e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KOG96945.1 - 3.5e-09 36.5 0.0 9.4e-09 35.1 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 KOG96945.1 - 2.1e-08 34.2 0.0 3.9e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOG96945.1 - 0.0039 17.0 0.0 0.0093 15.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOG96945.1 - 0.016 15.6 0.0 0.027 14.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain TIG PF01833.19 KOG96945.1 - 0.22 11.5 4.0 0.44 10.5 2.8 1.4 1 0 0 1 1 1 0 IPT/TIG domain DnaJ PF00226.26 KOG96946.1 - 5e-26 90.2 1.0 1.7e-25 88.5 0.7 2.0 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.3 KOG96946.1 - 1.3e-08 34.7 4.6 1.3e-08 34.7 3.2 3.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 KOG96946.1 - 3.5e-07 30.2 8.4 0.0021 18.1 2.4 3.2 2 1 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 KOG96946.1 - 2.5e-06 27.4 9.5 0.0032 17.7 1.4 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-met PF12874.2 KOG96946.1 - 6.8e-06 26.0 3.2 6.8e-06 26.0 2.2 2.7 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 KOG96946.1 - 0.00023 21.2 2.7 0.05 13.9 0.4 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KOG96946.1 - 0.043 13.7 15.1 0.15 12.0 0.4 3.3 4 0 0 4 4 4 0 C2H2-type zinc finger SID PF11778.3 KOG96947.1 - 3.4e-51 172.7 4.4 7.7e-51 171.6 3.0 1.6 1 0 0 1 1 1 1 Septation initiation GAS PF13851.1 KOG96947.1 - 0.00042 19.5 42.3 0.00085 18.5 14.7 3.4 2 1 1 3 3 3 3 Growth-arrest specific micro-tubule binding IncA PF04156.9 KOG96947.1 - 0.04 13.5 34.2 0.17 11.4 12.6 3.0 2 1 1 3 3 3 0 IncA protein HrpB7 PF09486.5 KOG96947.1 - 0.089 12.7 4.4 0.75 9.7 0.4 2.8 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) Reo_sigmaC PF04582.7 KOG96947.1 - 1.5 7.9 11.4 0.033 13.3 1.8 2.4 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Laminin_II PF06009.7 KOG96947.1 - 4.9 6.9 25.4 1.7 8.4 0.9 3.6 2 1 1 3 3 3 0 Laminin Domain II Mnd1 PF03962.10 KOG96947.1 - 5.4 6.6 33.8 0.2 11.3 8.2 3.5 2 1 1 3 3 3 0 Mnd1 family ADIP PF11559.3 KOG96947.1 - 6.9 6.5 40.2 0.02 14.7 11.0 3.7 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding G-patch PF01585.18 KOG96948.1 - 4.2e-14 52.0 1.8 8.8e-14 51.0 1.3 1.6 1 0 0 1 1 1 1 G-patch domain DUF972 PF06156.8 KOG96948.1 - 0.059 13.7 0.9 0.23 11.8 0.6 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF972) R3H PF01424.17 KOG96948.1 - 0.092 12.4 0.0 0.25 11.0 0.0 1.8 1 0 0 1 1 1 0 R3H domain Peptidase_C54 PF03416.14 KOG96949.1 - 7e-90 300.9 0.0 9.7e-90 300.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 Ssu72 PF04722.8 KOG96950.1 - 8.2e-90 299.3 0.1 9.3e-90 299.1 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein POP1 PF06978.6 KOG96951.1 - 3.9e-66 222.2 11.5 1.1e-65 220.8 8.0 1.8 1 0 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.7 KOG96951.1 - 8.1e-31 105.7 3.8 8.2e-31 105.7 1.5 1.9 2 0 0 2 2 2 1 POPLD (NUC188) domain GCV_T_C PF08669.6 KOG96951.1 - 0.01 15.8 0.0 0.031 14.3 0.0 1.8 2 0 0 2 2 2 0 Glycine cleavage T-protein C-terminal barrel domain DUF3868 PF12984.2 KOG96951.1 - 0.079 12.4 0.0 3 7.3 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3868) GCV_T PF01571.16 KOG96951.1 - 0.16 11.3 0.0 1.2 8.4 0.0 2.1 2 0 0 2 2 2 0 Aminomethyltransferase folate-binding domain Adenylsucc_synt PF00709.16 KOG96952.1 - 2.1e-164 547.2 0.0 2.3e-164 547.0 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Glyco_transf_22 PF03901.12 KOG96953.1 - 4e-102 342.3 31.3 4.9e-102 342.0 21.7 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family MgsA_C PF12002.3 KOG96954.1 - 7.5e-52 175.4 1.1 1.2e-51 174.7 0.1 1.8 2 0 0 2 2 1 1 MgsA AAA+ ATPase C terminal AAA PF00004.24 KOG96954.1 - 7.1e-15 55.3 0.2 2.1e-14 53.8 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOG96954.1 - 7.3e-14 51.3 0.1 3.7e-13 49.0 0.0 2.1 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 KOG96954.1 - 5.6e-08 32.7 0.0 1.6e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOG96954.1 - 6.2e-07 29.2 0.0 1.3e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOG96954.1 - 7.5e-07 29.3 0.2 0.00034 20.6 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOG96954.1 - 3.6e-06 27.1 1.0 0.0001 22.4 0.7 2.7 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 KOG96954.1 - 3.3e-05 23.4 0.1 0.00019 20.9 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.16 KOG96954.1 - 7.2e-05 22.0 0.3 0.11 11.6 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 KOG96954.1 - 0.0015 17.3 0.0 0.0047 15.6 0.0 1.8 1 1 1 2 2 2 1 TIP49 C-terminus IstB_IS21 PF01695.12 KOG96954.1 - 0.0017 17.8 0.0 0.0028 17.0 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.9 KOG96954.1 - 0.0018 18.2 0.0 0.0062 16.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.1 KOG96954.1 - 0.003 17.6 0.0 0.012 15.6 0.0 2.0 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_17 PF13207.1 KOG96954.1 - 0.0035 18.1 0.1 0.019 15.7 0.0 2.2 1 1 0 2 2 1 1 AAA domain AAA_18 PF13238.1 KOG96954.1 - 0.0038 17.5 0.0 0.017 15.4 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 KOG96954.1 - 0.0069 15.9 0.0 0.015 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 KOG96954.1 - 0.01 15.5 0.1 0.025 14.2 0.0 1.6 1 1 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 KOG96954.1 - 0.01 15.9 0.0 0.036 14.2 0.0 2.0 1 0 0 1 1 1 0 RNA helicase AAA_10 PF12846.2 KOG96954.1 - 0.014 14.8 0.4 1.1 8.5 0.0 2.5 1 1 1 2 2 2 0 AAA-like domain DUF815 PF05673.8 KOG96954.1 - 0.017 14.0 0.0 0.029 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) MMR_HSR1 PF01926.18 KOG96954.1 - 0.017 15.0 0.0 0.055 13.4 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.22 KOG96954.1 - 0.031 14.5 0.2 0.094 13.0 0.1 2.0 1 1 0 1 1 1 0 ABC transporter AAA_28 PF13521.1 KOG96954.1 - 0.037 13.9 0.0 0.43 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 KOG96954.1 - 0.04 13.6 1.0 0.11 12.1 0.3 2.1 2 1 0 2 2 1 0 Archaeal ATPase AAA_30 PF13604.1 KOG96954.1 - 0.12 11.9 0.0 0.46 10.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 KOG96954.1 - 0.14 11.9 4.4 3.3 7.5 2.7 2.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Rtt102p PF09510.5 KOG96954.1 - 0.19 11.7 2.5 0.3 11.0 0.1 2.2 2 0 0 2 2 2 0 Rtt102p-like transcription regulator protein Sgf11 PF08209.6 KOG96954.1 - 0.26 10.6 1.0 0.36 10.1 0.1 1.7 2 0 0 2 2 1 0 Sgf11 (transcriptional regulation protein) Metallophos PF00149.23 KOG96955.1 - 1.7e-13 50.4 1.2 2.6e-13 49.8 0.9 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOG96955.1 - 0.0012 18.6 0.4 0.0016 18.3 0.3 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain FBPase_2 PF06874.6 KOG96955.1 - 0.0018 16.3 0.3 0.15 10.0 0.0 2.1 1 1 1 2 2 2 2 Firmicute fructose-1,6-bisphosphatase Rap1-DNA-bind PF09197.5 KOG96956.1 - 5.6e-46 155.4 3.3 6.3e-42 142.4 0.6 3.1 2 0 0 2 2 2 2 Rap1, DNA-binding Rap1_C PF11626.3 KOG96956.1 - 1.2e-24 85.9 0.0 1.1e-23 82.8 0.0 2.6 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-binding PF00249.26 KOG96956.1 - 1.9e-09 37.3 1.9 1e-06 28.6 0.0 3.9 3 1 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.6 KOG96956.1 - 1.4e-08 34.3 0.4 7.5e-05 22.4 0.0 2.6 2 0 0 2 2 2 2 Rap1 Myb domain Myb_DNA-bind_6 PF13921.1 KOG96956.1 - 2e-05 24.6 0.4 0.13 12.3 0.0 4.2 3 1 0 3 3 3 2 Myb-like DNA-binding domain BRCT PF00533.21 KOG96956.1 - 0.0055 16.8 0.0 0.047 13.8 0.0 2.4 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PAPA-1 PF04795.7 KOG96957.1 - 9e-15 55.1 5.1 9e-15 55.1 3.5 3.3 3 1 0 3 3 3 1 PAPA-1-like conserved region DUF966 PF06136.8 KOG96957.1 - 0.16 11.3 19.7 0.26 10.6 13.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) YgaB PF14182.1 KOG96958.1 - 0.57 10.4 5.0 0.21 11.8 0.8 2.2 2 1 0 2 2 2 0 YgaB-like protein Neugrin PF06413.6 KOG96959.1 - 3.8e-07 30.1 1.4 6.7e-07 29.3 0.6 1.8 1 1 0 1 1 1 1 Neugrin HTH_24 PF13412.1 KOG96959.1 - 0.00066 19.0 0.1 0.015 14.6 0.0 2.5 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Sigma70_r4 PF04545.11 KOG96959.1 - 0.00096 18.4 0.0 0.002 17.4 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_11 PF08279.7 KOG96959.1 - 0.0021 17.6 0.0 0.0054 16.3 0.0 1.8 1 0 0 1 1 1 1 HTH domain MarR_2 PF12802.2 KOG96959.1 - 0.0044 16.6 0.0 0.0079 15.8 0.0 1.4 1 0 0 1 1 1 1 MarR family Mod_r PF07200.8 KOG96959.1 - 0.0045 16.9 2.6 0.0075 16.1 1.8 1.4 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein MarR PF01047.17 KOG96959.1 - 0.0095 15.6 0.0 0.036 13.7 0.0 2.0 2 0 0 2 2 2 1 MarR family HTH_7 PF02796.10 KOG96959.1 - 0.013 15.3 0.0 0.16 11.8 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase HTH_Tnp_ISL3 PF13542.1 KOG96959.1 - 0.025 13.7 0.0 0.05 12.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.1 KOG96959.1 - 0.032 13.8 0.0 0.11 12.1 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain DUF134 PF02001.11 KOG96959.1 - 0.044 13.6 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF134 HTH_36 PF13730.1 KOG96959.1 - 0.048 13.7 0.1 0.9 9.7 0.0 2.6 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_28 PF13518.1 KOG96959.1 - 0.075 13.0 0.1 0.27 11.2 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain DUF3987 PF13148.1 KOG96959.1 - 2 6.8 7.4 0.39 9.2 1.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3987) VHP PF02209.14 KOG96959.1 - 9.2 6.0 13.3 4.6 7.0 0.1 4.0 4 1 0 4 4 4 0 Villin headpiece domain VID27 PF08553.5 KOG96960.1 - 0 1038.1 12.8 0 1036.9 8.8 1.5 1 1 0 1 1 1 1 VID27 cytoplasmic protein DUF2697 PF10906.3 KOG96961.1 - 8.1e-34 115.4 0.9 9.7e-34 115.2 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2697) KH_1 PF00013.24 KOG96962.1 - 7.9e-08 31.8 0.3 1.4e-07 31.0 0.2 1.4 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 KOG96962.1 - 3.8e-05 23.2 0.1 6.8e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 KOG96962.1 - 0.039 13.5 0.1 0.088 12.3 0.1 1.6 1 0 0 1 1 1 0 KH domain HSP70 PF00012.15 KOG96963.1 - 4.5e-235 781.1 9.1 5e-235 781.0 6.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOG96963.1 - 4.8e-18 64.8 0.4 1.7e-16 59.7 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 KOG96963.1 - 0.0047 16.5 0.0 0.0083 15.7 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 KOG96963.1 - 1 9.2 11.0 1e+02 2.7 3.9 4.3 2 1 0 2 2 2 0 Cell division protein FtsA Rick_17kDa_Anti PF05433.10 KOG96964.1 - 4.1e-09 35.9 3.9 1.1e-08 34.5 2.7 1.8 1 0 0 1 1 1 1 Glycine zipper 2TM domain Gly-zipper_OmpA PF13436.1 KOG96964.1 - 0.00026 20.6 6.0 0.00047 19.8 4.2 1.4 1 0 0 1 1 1 1 Glycine-zipper containing OmpA-like membrane domain Gly-zipper_Omp PF13488.1 KOG96964.1 - 1.2 8.8 10.1 0.8 9.3 1.7 2.4 1 1 1 2 2 2 0 Glycine zipper RIO1 PF01163.17 KOG96965.1 - 1.6e-42 145.0 0.2 2.4e-42 144.4 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.6 KOG96965.1 - 6.5e-31 106.2 0.1 1.3e-30 105.3 0.1 1.5 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.18 KOG96965.1 - 1.3e-05 25.0 0.1 0.12 12.1 0.4 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 KOG96965.1 - 0.018 14.1 0.1 0.5 9.3 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 KOG96965.1 - 0.023 13.8 0.1 0.037 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein kinase domain Paf1 PF03985.8 KOG96965.1 - 1.3 7.6 14.2 2 7.0 9.8 1.1 1 0 0 1 1 1 0 Paf1 Cwf_Cwc_15 PF04889.7 KOG96965.1 - 2.4 7.7 14.1 3.7 7.1 9.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.9 KOG96965.1 - 5 5.0 14.9 7 4.5 10.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Rtt106 PF08512.7 KOG96966.1 - 9.4e-30 102.4 0.4 2.3e-29 101.2 0.2 1.8 2 0 0 2 2 2 1 Histone chaperone Rttp106-like NOA36 PF06524.7 KOG96966.1 - 0.81 8.8 21.5 1.4 8.0 14.9 1.3 1 0 0 1 1 1 0 NOA36 protein Topoisom_I_N PF02919.10 KOG96966.1 - 2.3 7.4 8.7 0.7 9.1 1.5 2.8 3 0 0 3 3 3 0 Eukaryotic DNA topoisomerase I, DNA binding fragment ArfGap PF01412.13 KOG96967.1 - 4.5e-23 81.2 0.4 7.7e-23 80.5 0.3 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf CENP-M PF11111.3 KOG96967.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) adh_short_C2 PF13561.1 KOG96968.1 - 3.5e-28 98.9 0.0 4.4e-28 98.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 KOG96968.1 - 2.7e-22 79.4 0.4 3.9e-22 78.9 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOG96968.1 - 3.3e-09 36.6 0.1 5.5e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.15 KOG96968.1 - 0.028 14.5 0.1 0.05 13.6 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Hydrolase_4 PF12146.3 KOG96968.1 - 0.046 13.5 0.0 6.1 6.7 0.0 2.4 2 0 0 2 2 2 0 Putative lysophospholipase Epimerase PF01370.16 KOG96968.1 - 0.096 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family SMK-1 PF04802.10 KOG96969.1 - 2.2e-65 219.8 8.5 2.2e-65 219.8 5.9 2.0 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 HEAT PF02985.17 KOG96969.1 - 0.084 12.9 0.1 12 6.3 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat YjeF_N PF03853.10 KOG96970.1 - 5e-37 127.1 0.0 5.9e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus RRM_1 PF00076.17 KOG96972.1 - 3e-17 61.9 0.0 5e-16 58.0 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG96972.1 - 2.6e-07 30.5 0.0 3.3e-06 26.9 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Borrelia_P83 PF05262.6 KOG96972.1 - 0.0011 17.3 24.9 0.0017 16.7 17.2 1.3 1 0 0 1 1 1 1 Borrelia P83/100 protein Med15 PF09606.5 KOG96972.1 - 0.68 8.0 133.9 1.1 7.3 92.8 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal LMBR1 PF04791.11 KOG96972.1 - 2 6.9 12.0 2.9 6.3 8.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein TFIIA PF03153.8 KOG96972.1 - 2.7 7.7 84.7 0.63 9.8 42.9 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SUR7 PF06687.7 KOG96975.1 - 2.9e-36 125.0 15.6 3.7e-36 124.6 10.8 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF2678 PF10856.3 KOG96975.1 - 0.013 15.2 2.1 0.028 14.1 1.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2678) TYA PF01021.14 KOG96975.1 - 0.035 14.2 0.3 0.063 13.4 0.2 1.4 1 0 0 1 1 1 0 TYA transposon protein Chitin_synth_1 PF01644.12 KOG96977.1 - 1.4e-74 249.2 0.1 2.2e-74 248.6 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 KOG96977.1 - 4e-26 90.5 0.1 9e-26 89.3 0.1 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 KOG96977.1 - 9.3e-17 60.5 11.6 2e-12 46.3 2.6 2.6 2 1 1 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.1 KOG96977.1 - 4.8e-12 45.9 1.5 4.8e-12 45.9 1.1 1.9 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 KOG96977.1 - 4.5e-09 36.4 0.0 1.1e-08 35.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 DUF3989 PF13150.1 KOG96977.1 - 0.63 9.5 3.4 21 4.6 0.2 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) GATase_4 PF13230.1 KOG96978.1 - 8e-19 67.3 0.0 4.1e-18 65.0 0.0 1.9 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.1 KOG96978.1 - 2.5e-12 46.8 0.0 6.8e-12 45.4 0.0 1.7 1 1 1 2 2 2 1 Glutamine amidotransferase domain GATase_2 PF00310.16 KOG96978.1 - 3.6e-10 39.0 0.0 1.9e-08 33.3 0.0 2.1 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_7 PF13537.1 KOG96978.1 - 0.0049 16.5 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain KIAA1328 PF15369.1 KOG96979.1 - 3.9 7.2 7.9 4.6 6.9 5.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 L31 PF09784.4 KOG96979.1 - 8.2 6.5 27.0 49 4.0 8.3 3.1 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L31 Arm PF00514.18 KOG96980.1 - 2.3e-86 281.0 13.1 1.3e-11 43.8 0.2 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.15 KOG96980.1 - 1.3e-27 95.7 6.1 2.6e-27 94.8 4.3 1.5 1 0 0 1 1 1 1 Importin beta binding domain HEAT_2 PF13646.1 KOG96980.1 - 1.1e-20 73.6 0.6 3.1e-05 24.1 0.0 5.6 1 1 5 6 6 6 6 HEAT repeats HEAT_EZ PF13513.1 KOG96980.1 - 2.7e-16 59.4 3.0 0.00018 21.9 0.0 6.3 5 2 2 7 7 7 4 HEAT-like repeat HEAT PF02985.17 KOG96980.1 - 3.7e-11 42.1 0.4 6.7 7.0 0.0 7.7 8 0 0 8 8 8 1 HEAT repeat Arm_2 PF04826.8 KOG96980.1 - 2.9e-07 29.8 0.4 0.015 14.3 0.0 4.0 3 2 1 4 4 4 3 Armadillo-like Proteasom_PSMB PF10508.4 KOG96980.1 - 3.6e-06 25.5 2.7 0.00013 20.4 0.2 2.7 3 0 0 3 3 3 2 Proteasome non-ATPase 26S subunit V-ATPase_H_C PF11698.3 KOG96980.1 - 4.6e-05 23.3 0.3 0.14 12.0 0.0 4.2 3 2 1 4 4 4 1 V-ATPase subunit H Adaptin_N PF01602.15 KOG96980.1 - 5.2e-05 21.7 0.9 0.001 17.5 0.6 3.0 1 1 0 1 1 1 1 Adaptin N terminal region RICTOR_V PF14668.1 KOG96980.1 - 0.00036 20.3 3.6 7.3 6.5 0.1 5.2 3 3 4 7 7 7 2 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_PBS PF03130.11 KOG96980.1 - 0.02 15.2 0.8 46 4.8 0.1 4.5 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat FAST_1 PF06743.10 KOG96980.1 - 0.14 11.8 0.1 1.2 8.9 0.0 2.6 4 0 0 4 4 4 0 FAST kinase-like protein, subdomain 1 Dynactin PF12455.3 KOG96981.1 - 0.051 12.4 0.2 0.087 11.7 0.1 1.2 1 0 0 1 1 1 0 Dynein associated protein Lactonase PF10282.4 KOG96982.1 - 0.0063 15.6 0.0 0.01 14.9 0.0 1.3 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller UCH PF00443.24 KOG96983.1 - 9.2e-57 192.1 1.7 2.1e-56 191.0 1.2 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOG96983.1 - 2.8e-12 46.6 3.7 2.8e-12 46.6 2.6 3.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DNA_RNApol_7kD PF03604.8 KOG96983.1 - 0.16 11.4 2.4 3.2 7.3 0.1 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Ribosomal_L11 PF00298.14 KOG96984.1 - 1.7e-27 95.3 0.7 3.1e-27 94.4 0.5 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.9 KOG96984.1 - 1.1e-25 88.8 0.6 1.8e-25 88.1 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Pkinase PF00069.20 KOG96985.1 - 8e-66 221.8 0.0 1.2e-65 221.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG96985.1 - 1.1e-22 80.3 0.0 1.9e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG96985.1 - 0.024 13.6 0.0 0.076 11.9 0.0 1.7 2 0 0 2 2 2 0 Kinase-like APH PF01636.18 KOG96985.1 - 0.22 11.2 0.0 0.35 10.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family WD40 PF00400.27 KOG96986.1 - 1.5e-08 34.2 1.7 0.047 13.5 0.0 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat CBM_19 PF03427.8 KOG96986.1 - 0.087 12.6 3.8 0.18 11.5 0.7 2.7 3 0 0 3 3 3 0 Carbohydrate binding domain (family 19) MRP-L28 PF09812.4 KOG96986.1 - 0.15 11.8 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 adh_short PF00106.20 KOG96987.1 - 6.2e-07 29.4 0.0 1e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOG96987.1 - 1.1e-05 25.2 0.0 2.1e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 KOG96987.1 - 0.0031 17.2 0.0 0.0055 16.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ras PF00071.17 KOG96988.1 - 8.1e-45 152.1 0.1 7.3e-43 145.7 0.1 2.4 1 1 0 1 1 1 1 Ras family Miro PF08477.8 KOG96988.1 - 1.2e-14 54.8 2.2 1.3e-13 51.4 0.0 3.3 2 2 0 2 2 2 1 Miro-like protein Arf PF00025.16 KOG96988.1 - 3.5e-06 26.3 0.0 0.014 14.6 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Ribosomal_S3_C PF00189.15 KOG96989.1 - 1.6e-15 57.0 0.1 2.8e-15 56.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.12 KOG96989.1 - 6.9e-12 44.7 0.0 2.3e-11 43.0 0.0 1.9 2 0 0 2 2 2 1 KH domain Ribosomal_L22 PF00237.14 KOG96990.1 - 2.9e-18 65.7 0.1 1e-17 63.9 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e Ribosomal_L9_C PF03948.9 KOG96990.1 - 0.064 13.3 0.1 0.51 10.4 0.0 2.5 3 0 0 3 3 3 0 Ribosomal protein L9, C-terminal domain Syndecan PF01034.15 KOG96991.1 - 0.019 14.5 0.0 0.038 13.6 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain RRM_1 PF00076.17 KOG96992.1 - 2.7e-26 90.9 6.0 8.4e-18 63.7 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG96992.1 - 1.9e-19 69.4 3.2 1.1e-12 47.7 0.0 3.6 3 1 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG96992.1 - 6.9e-09 35.4 0.6 1.4e-06 28.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KOG96992.1 - 0.018 14.8 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif CDV3 PF15359.1 KOG96993.1 - 0.67 10.0 14.3 0.038 14.0 4.4 2.3 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 Apc1 PF12859.2 KOG96994.1 - 2.9e-14 53.1 0.3 2.1e-13 50.3 0.0 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.17 KOG96994.1 - 0.11 12.8 8.2 34 4.9 0.0 4.9 4 0 0 4 4 4 0 Proteasome/cyclosome repeat PS_Dcarbxylase PF02666.10 KOG96995.1 - 8.2e-73 244.0 0.0 1.2e-72 243.5 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Biotin_lipoyl PF00364.17 KOG96995.1 - 0.011 15.4 1.2 0.13 11.9 0.0 2.4 2 0 0 2 2 2 0 Biotin-requiring enzyme HVSL PF09749.4 KOG96995.1 - 0.046 12.7 0.0 0.082 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein NADH_oxidored PF08040.6 KOG96995.1 - 0.052 13.1 0.0 0.16 11.5 0.0 1.8 1 0 0 1 1 1 0 MNLL subunit FAA_hydrolase PF01557.13 KOG96996.1 - 5.4e-49 166.5 0.0 7.1e-49 166.2 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family bZIP_1 PF00170.16 KOG96997.1 - 4.1e-07 29.8 1.6 4.1e-07 29.8 1.1 1.7 2 0 0 2 2 2 1 bZIP transcription factor Aft1_OSA PF11785.3 KOG96997.1 - 4.8e-06 27.0 0.8 4.8e-06 27.0 0.5 4.4 3 1 1 4 4 4 1 Aft1 osmotic stress response (OSM) domain bZIP_2 PF07716.10 KOG96997.1 - 4.2e-05 23.2 3.8 4.2e-05 23.2 2.6 1.9 2 0 0 2 2 2 1 Basic region leucine zipper ATP13 PF12921.2 KOG96997.1 - 0.014 14.7 0.2 0.034 13.4 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial ATPase expression Suppressor_APC PF11414.3 KOG96998.1 - 0.061 13.1 0.7 4.3 7.1 0.0 2.6 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein HtaA PF04213.8 KOG97000.1 - 0.053 13.7 0.1 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Htaa GTP_EFTU PF00009.22 KOG97001.1 - 4.6e-54 182.7 0.0 7.4e-54 182.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 KOG97001.1 - 4.4e-13 48.9 0.0 1.5e-12 47.2 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 KOG97001.1 - 1.6e-10 40.9 0.0 4e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 KOG97001.1 - 3e-09 36.5 0.0 6.9e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.13 KOG97001.1 - 0.00016 21.1 0.0 0.00058 19.4 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G, domain IV MMR_HSR1 PF01926.18 KOG97001.1 - 0.0026 17.6 0.0 0.0084 16.0 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF952 PF06108.7 KOG97001.1 - 0.14 12.0 0.0 0.47 10.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF952) DZR PF12773.2 KOG97002.1 - 0.025 14.3 1.2 0.035 13.9 0.8 1.3 1 0 0 1 1 1 0 Double zinc ribbon zf-C2H2 PF00096.21 KOG97002.1 - 0.054 13.8 1.8 1.3 9.5 0.0 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type UPF0547 PF10571.4 KOG97002.1 - 0.068 12.8 1.9 2.4 7.9 0.0 2.4 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 Zn-ribbon_8 PF09723.5 KOG97002.1 - 0.14 12.1 1.7 0.62 10.0 0.5 2.1 2 0 0 2 2 2 0 Zinc ribbon domain IBR PF01485.16 KOG97002.1 - 0.4 10.5 3.1 1.7 8.5 0.2 2.1 1 1 1 2 2 2 0 IBR domain zf-ribbon_3 PF13248.1 KOG97002.1 - 0.44 9.8 2.4 1.2 8.4 0.1 2.5 3 0 0 3 3 3 0 zinc-ribbon domain Ribosomal_L44 PF00935.14 KOG97003.1 - 3.6e-34 116.6 12.0 5.6e-34 115.9 8.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 Pkinase PF00069.20 KOG97004.1 - 2.2e-56 190.9 0.3 1.1e-39 136.1 0.1 3.4 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97004.1 - 4.8e-24 84.8 0.3 2.1e-20 72.8 0.0 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_C PF00433.19 KOG97004.1 - 0.0045 17.4 0.1 0.0045 17.4 0.1 2.4 2 0 0 2 2 2 1 Protein kinase C terminal domain Seadorna_VP7 PF07387.6 KOG97004.1 - 0.023 13.5 0.0 0.04 12.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Paramyxo_ncap PF00973.14 KOG97004.1 - 3.7 6.1 20.2 6.3 5.3 14.0 1.4 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein RR_TM4-6 PF06459.7 KOG97004.1 - 9.8 5.9 29.4 3.5 7.4 18.0 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Asparaginase PF00710.15 KOG97005.1 - 2e-23 82.7 3.3 7e-23 80.9 2.3 1.7 1 1 0 1 1 1 1 Asparaginase Phospholamban PF04272.9 KOG97006.1 - 0.3 10.5 0.0 0.3 10.5 0.0 2.6 4 0 0 4 4 4 0 Phospholamban Pga1 PF10333.4 KOG97007.1 - 7.8e-64 214.6 2.8 9.5e-64 214.3 1.9 1.0 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Endosulfine PF04667.12 KOG97008.1 - 4.2e-32 109.9 0.2 6.2e-32 109.4 0.1 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region INSIG PF07281.7 KOG97009.1 - 2.3e-11 43.3 0.8 4.6e-11 42.4 0.3 1.8 1 1 1 2 2 2 1 Insulin-induced protein (INSIG) zf-AN1 PF01428.11 KOG97010.1 - 4.5e-13 48.8 10.7 7.4e-13 48.1 7.4 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger RE_NgoBV PF09564.5 KOG97010.1 - 0.023 13.9 0.5 0.032 13.4 0.3 1.2 1 0 0 1 1 1 0 NgoBV restriction endonuclease zf-DHHC PF01529.15 KOG97010.1 - 0.46 9.8 8.1 1.6 8.0 5.6 1.9 1 0 0 1 1 1 0 DHHC palmitoyltransferase Pkinase PF00069.20 KOG97011.1 - 7.1e-32 110.5 0.0 7.1e-32 110.5 0.0 2.1 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97011.1 - 3.1e-12 46.1 0.9 5.7e-12 45.2 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 KOG97011.1 - 1.5e-05 24.8 3.7 0.29 10.8 0.1 3.2 2 1 1 3 3 3 3 Phosphotransferase enzyme family Prefoldin_2 PF01920.15 KOG97012.1 - 3.9e-22 78.0 8.4 4.5e-22 77.8 5.8 1.1 1 0 0 1 1 1 1 Prefoldin subunit CCDC155 PF14662.1 KOG97012.1 - 0.011 15.2 4.5 0.69 9.4 0.1 2.1 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 SMK-1 PF04802.10 KOG97012.1 - 0.013 14.9 2.1 0.016 14.7 1.5 1.1 1 0 0 1 1 1 0 Component of IIS longevity pathway SMK-1 NUC194 PF08163.7 KOG97012.1 - 0.028 13.2 0.4 0.03 13.1 0.3 1.1 1 0 0 1 1 1 0 NUC194 domain DUF4140 PF13600.1 KOG97012.1 - 0.067 13.6 1.4 0.12 12.8 0.7 1.6 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF964 PF06133.6 KOG97012.1 - 0.1 12.5 6.9 0.18 11.8 2.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF964) Seryl_tRNA_N PF02403.17 KOG97012.1 - 1.6 8.8 9.4 2.2 8.3 0.8 2.2 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain C2 PF00168.25 KOG97013.1 - 0.00011 21.9 0.0 0.00022 21.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain RNA_pol_3_Rpc31 PF11705.3 KOG97014.1 - 1.9e-68 230.9 14.5 2.4e-68 230.5 10.1 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 PGA2 PF07543.7 KOG97015.1 - 1.3e-12 47.6 11.9 2e-06 27.6 0.8 2.0 1 1 1 2 2 2 2 Protein trafficking PGA2 DUF2852 PF11014.3 KOG97015.1 - 0.037 13.9 0.4 0.05 13.5 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) Anti-adapt_IraP PF10796.4 KOG97015.1 - 0.16 12.3 1.2 2.2 8.7 0.0 2.4 2 0 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein DivIC PF04977.10 KOG97015.1 - 4.1 6.9 8.6 0.73 9.3 0.1 2.2 1 1 1 2 2 2 0 Septum formation initiator CAP_GLY PF01302.20 KOG97016.1 - 5.9e-17 61.1 0.0 9.1e-17 60.5 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.1 KOG97016.1 - 8.4e-12 45.1 0.1 1.2e-11 44.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain LSM PF01423.17 KOG97017.1 - 1.1e-15 56.9 0.4 1.4e-15 56.5 0.3 1.2 1 0 0 1 1 1 1 LSM domain Tub_2 PF04525.7 KOG97019.1 - 0.016 14.6 0.0 0.016 14.6 0.0 1.0 1 0 0 1 1 1 0 Tubby C 2 Ammonium_transp PF00909.16 KOG97021.1 - 3e-128 427.7 30.9 3.4e-128 427.5 21.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3185 PF11381.3 KOG97021.1 - 0.1 12.3 8.7 7 6.4 0.4 4.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3185) A_deaminase PF00962.17 KOG97022.1 - 5.4e-96 321.3 0.0 6.1e-96 321.2 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase TRM PF02005.11 KOG97022.1 - 0.025 13.5 0.0 0.037 12.9 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase DUF3889 PF13028.1 KOG97022.1 - 0.17 11.5 0.9 1.5 8.4 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3889) Tho2 PF11262.3 KOG97023.1 - 4.7e-62 209.7 12.8 4.7e-62 209.7 8.9 3.7 3 1 0 3 3 3 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.3 KOG97023.1 - 6.7e-28 96.3 0.6 1.9e-27 94.8 0.4 1.9 1 0 0 1 1 1 1 Transcription- and export-related complex subunit CAP_N PF01213.14 KOG97025.1 - 1.2e-119 399.2 1.7 1.7e-119 398.7 1.2 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.6 KOG97025.1 - 2.1e-63 212.4 2.1 4.6e-63 211.3 0.9 1.8 2 0 0 2 2 2 1 Adenylate cyclase associated (CAP) C terminal S4 PF01479.20 KOG97026.1 - 3.1e-16 58.5 0.0 6e-16 57.6 0.0 1.5 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.1 KOG97026.1 - 0.0035 16.8 0.0 0.0072 15.8 0.0 1.5 1 0 0 1 1 1 1 S4 domain Eaf7 PF07904.8 KOG97027.1 - 3.5e-33 113.4 0.2 3.5e-33 113.4 0.1 2.8 3 1 0 3 3 3 1 Chromatin modification-related protein EAF7 FKBP_C PF00254.23 KOG97028.1 - 3.2e-33 113.6 0.0 3.7e-33 113.3 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase ADH_zinc_N PF00107.21 KOG97029.1 - 4.5e-12 45.6 0.0 7.1e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOG97029.1 - 0.0057 16.3 0.2 0.015 15.0 0.1 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Nefa_Nip30_N PF10187.4 KOG97030.1 - 0.0016 18.5 13.7 0.002 18.2 9.1 1.5 1 1 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 GNAT_acetyltr_2 PF13718.1 KOG97031.1 - 1.4e-81 272.5 0.0 3e-81 271.4 0.0 1.6 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.9 KOG97031.1 - 1.5e-65 220.1 0.0 6.4e-65 218.0 0.0 2.1 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.6 KOG97031.1 - 4.1e-40 135.3 0.0 1.5e-39 133.5 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.1 KOG97031.1 - 2.6e-37 126.9 0.8 9e-37 125.2 0.6 2.0 1 0 0 1 1 1 1 Possible tRNA binding domain Acetyltransf_7 PF13508.1 KOG97031.1 - 0.046 13.8 0.0 0.14 12.2 0.0 1.9 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Tom22 PF04281.8 KOG97032.1 - 8.9e-51 171.0 1.5 1e-50 170.8 1.0 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 CDP-OH_P_transf PF01066.16 KOG97033.1 - 5e-17 62.0 1.8 5e-17 62.0 1.3 2.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Herpes_pp38 PF04846.8 KOG97033.1 - 0.093 12.0 0.4 0.96 8.8 0.0 2.4 2 0 0 2 2 2 0 Herpesvirus pp38 phosphoprotein COX2-transmemb PF09125.5 KOG97033.1 - 0.099 12.2 1.4 1.6 8.3 0.8 3.0 1 1 1 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane AAA_18 PF13238.1 KOG97034.1 - 4e-09 36.8 0.2 2.2e-08 34.4 0.2 2.0 1 1 0 1 1 1 1 AAA domain PRK PF00485.13 KOG97034.1 - 3.2e-06 26.8 0.1 5.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.1 KOG97034.1 - 3.9e-06 27.6 0.3 2.8e-05 24.9 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOG97034.1 - 0.0035 17.4 0.0 0.0082 16.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain CPT PF07931.7 KOG97034.1 - 0.0075 15.9 0.4 0.044 13.4 0.3 2.3 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein tRNA_lig_kinase PF08303.6 KOG97034.1 - 0.011 15.5 0.2 0.079 12.8 0.0 2.1 2 0 0 2 2 2 0 tRNA ligase kinase domain Spermine_synth PF01564.12 KOG97034.1 - 0.046 12.6 0.0 0.07 12.0 0.0 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase AAA_33 PF13671.1 KOG97034.1 - 0.046 13.5 0.0 0.1 12.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 KOG97034.1 - 0.068 13.1 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 KOG97034.1 - 0.083 11.9 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF927 PF06048.6 KOG97034.1 - 0.12 11.6 0.0 0.67 9.1 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF927) DSPc PF00782.15 KOG97035.1 - 8.8e-10 38.2 0.0 1.9e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 KOG97035.1 - 0.00017 21.6 0.0 0.00039 20.4 0.0 1.7 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 KOG97035.1 - 0.01 16.0 0.0 0.025 14.8 0.0 1.7 1 1 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.22 KOG97035.1 - 0.03 13.6 0.0 0.062 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DUF3402 PF11882.3 KOG97036.1 - 5.9e-86 289.0 12.0 5.9e-86 289.0 8.3 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3402) N1221 PF07923.8 KOG97036.1 - 4.7e-76 255.4 2.8 7.9e-76 254.6 1.9 1.4 1 0 0 1 1 1 1 N1221-like protein Daxx PF03344.10 KOG97036.1 - 6.5 5.1 20.4 11 4.3 14.2 1.3 1 0 0 1 1 1 0 Daxx Family Spc97_Spc98 PF04130.8 KOG97037.1 - 4.7e-74 249.6 19.7 1.1e-73 248.4 13.7 1.5 1 0 0 1 1 1 1 Spc97 / Spc98 family MFS_1 PF07690.11 KOG97038.1 - 5e-28 97.8 65.8 5.5e-22 77.9 29.4 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 KOG97038.1 - 8.8e-07 27.8 23.6 1.3e-05 23.9 1.1 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter Gar1 PF04410.9 KOG97039.1 - 1.4e-45 154.5 0.0 1.4e-45 154.5 0.0 3.0 3 1 0 3 3 3 1 Gar1/Naf1 RNA binding region PAT1 PF09770.4 KOG97039.1 - 7 4.7 72.7 14 3.7 50.4 1.5 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PDZ_1 PF12812.2 KOG97040.1 - 4.1e-53 177.1 0.2 1.1e-35 121.3 0.0 3.2 3 0 0 3 3 3 2 PDZ-like domain Trypsin_2 PF13365.1 KOG97040.1 - 1.1e-13 51.2 0.3 1.2e-10 41.4 0.0 2.5 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_2 PF13180.1 KOG97040.1 - 3e-11 43.0 4.1 0.00069 19.4 0.1 4.4 4 0 0 4 4 4 2 PDZ domain PDZ PF00595.19 KOG97040.1 - 7.8e-11 42.0 0.2 8.2e-08 32.3 0.0 3.0 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) Trypsin PF00089.21 KOG97040.1 - 0.00043 19.9 0.0 0.0013 18.3 0.0 1.8 1 1 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.1 KOG97040.1 - 0.0026 17.5 0.4 0.25 11.1 0.1 3.1 3 0 0 3 3 3 1 Tricorn protease PDZ domain DUF31 PF01732.11 KOG97040.1 - 0.011 15.0 0.1 0.018 14.4 0.1 1.3 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S7 PF00949.16 KOG97040.1 - 0.038 13.3 0.2 0.1 12.0 0.1 1.7 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Ribosomal_L35p PF01632.14 KOG97041.1 - 1.1e-06 28.4 4.5 1.6e-06 27.9 3.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L35 TPR_11 PF13414.1 KOG97042.1 - 9.1e-40 134.1 21.6 1.7e-16 59.5 0.3 7.4 3 2 5 9 9 9 9 TPR repeat TPR_16 PF13432.1 KOG97042.1 - 7.1e-28 96.6 5.0 1.8e-06 28.4 0.0 6.6 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOG97042.1 - 2.3e-26 89.5 22.7 6.6e-05 22.5 0.0 11.6 10 1 1 11 11 11 5 Tetratricopeptide repeat TPR_1 PF00515.23 KOG97042.1 - 2.6e-25 86.9 30.4 3.4e-07 29.6 2.1 11.1 10 1 1 11 11 11 5 Tetratricopeptide repeat TPR_12 PF13424.1 KOG97042.1 - 7.4e-20 70.6 18.3 5.6e-06 26.2 0.0 8.3 4 3 4 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.1 KOG97042.1 - 2.9e-17 61.5 4.7 0.22 12.2 0.0 9.7 5 3 5 10 10 10 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOG97042.1 - 8.2e-15 54.8 14.9 0.00017 21.8 1.0 7.5 5 2 3 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOG97042.1 - 5.4e-14 50.8 30.5 0.0079 15.9 1.0 9.8 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_17 PF13431.1 KOG97042.1 - 1.1e-12 47.0 14.3 0.39 11.0 0.1 9.6 9 1 0 9 9 9 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOG97042.1 - 4.5e-10 38.5 12.6 0.23 11.3 0.0 7.2 8 1 0 8 8 6 3 Tetratricopeptide repeat Apc3 PF12895.2 KOG97042.1 - 8.6e-08 32.2 12.8 0.012 15.7 0.1 5.1 2 2 3 5 5 5 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 KOG97042.1 - 0.00022 21.0 0.6 5.6 6.8 0.0 5.0 5 1 0 5 5 5 1 Tetratricopeptide repeat SPO22 PF08631.5 KOG97042.1 - 0.07 12.2 4.0 0.45 9.5 0.3 3.3 3 0 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like DUF3808 PF10300.4 KOG97042.1 - 0.084 11.4 10.8 0.25 9.8 0.2 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF3808) SHNi-TPR PF10516.4 KOG97042.1 - 0.16 11.2 3.6 16 4.8 0.0 4.3 3 0 0 3 3 3 0 SHNi-TPR PPR PF01535.15 KOG97042.1 - 0.19 11.7 7.5 87 3.4 0.0 6.2 7 0 0 7 7 6 0 PPR repeat HemY_N PF07219.8 KOG97042.1 - 0.22 11.0 2.5 5.8 6.5 1.0 3.1 3 0 0 3 3 3 0 HemY protein N-terminus DUF2392 PF10288.4 KOG97043.1 - 3.7e-29 101.1 1.7 3.7e-29 101.1 1.2 2.6 3 1 1 4 4 4 1 Protein of unknown function (DUF2392) GFA PF04828.9 KOG97043.1 - 0.041 13.8 2.2 1.7 8.6 0.0 3.1 3 0 0 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme DCP2 PF05026.8 KOG97044.1 - 4.1e-33 113.1 1.1 9.2e-33 112.0 0.8 1.6 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.23 KOG97044.1 - 1.6e-14 53.7 0.0 2.9e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Malate_synthase PF01274.17 KOG97045.1 - 3.7e-223 741.2 0.0 4.3e-223 741.0 0.0 1.0 1 0 0 1 1 1 1 Malate synthase FHA PF00498.21 KOG97046.1 - 3.2e-15 55.9 0.1 7.1e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 FHA domain zf-RING_2 PF13639.1 KOG97046.1 - 9.7e-05 22.1 12.6 0.00018 21.2 8.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOG97046.1 - 0.0024 17.9 5.4 0.0058 16.7 3.8 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 KOG97046.1 - 0.022 14.6 3.3 0.045 13.5 2.3 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 KOG97046.1 - 0.056 13.0 12.9 0.1 12.2 9.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Sec_GG PF07549.9 KOG97046.1 - 0.067 12.4 0.6 0.16 11.2 0.4 1.6 1 0 0 1 1 1 0 SecD/SecF GG Motif zf-RING_5 PF14634.1 KOG97046.1 - 0.083 12.6 10.8 0.14 11.9 7.5 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Spt5_N PF11942.3 KOG97046.1 - 0.21 12.2 7.7 5.6 7.6 0.0 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal zf-C3HC4_2 PF13923.1 KOG97046.1 - 2.5 8.2 15.0 4.3 7.4 10.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF2417 PF10329.4 KOG97047.1 - 5.8e-74 248.4 5.8 7.7e-74 247.9 4.0 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_1 PF00561.15 KOG97047.1 - 1e-23 84.1 0.0 1.7e-23 83.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOG97047.1 - 2.3e-10 40.7 0.0 3e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family RNA_pol_L_2 PF13656.1 KOG97048.1 - 7.7e-31 105.3 0.0 1.3e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 KOG97048.1 - 1.4e-12 46.4 0.0 2.3e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RabGAP-TBC PF00566.13 KOG97048.1 - 0.14 11.6 0.1 0.24 10.8 0.1 1.2 1 1 0 1 1 1 0 Rab-GTPase-TBC domain Cyt-b5 PF00173.23 KOG97049.1 - 5.5e-24 83.7 0.2 6.9e-24 83.4 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TPR_5 PF12688.2 KOG97049.1 - 0.017 15.1 0.0 0.024 14.6 0.0 1.1 1 0 0 1 1 1 0 Tetratrico peptide repeat RRM_1 PF00076.17 KOG97050.1 - 4.7e-17 61.3 0.0 1.1e-16 60.1 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG97050.1 - 1.7e-12 47.0 0.0 5.4e-12 45.5 0.0 1.9 2 1 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG97050.1 - 2.9e-09 36.6 0.0 6e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 KOG97050.1 - 0.082 12.6 0.1 0.47 10.2 0.0 2.4 2 1 0 2 2 2 0 Limkain b1 DUF2129 PF09902.4 KOG97050.1 - 0.51 10.1 4.7 3.5 7.5 0.1 3.7 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2129) His_Phos_1 PF00300.17 KOG97051.1 - 2e-22 79.9 0.0 2.7e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) YEATS PF03366.11 KOG97052.1 - 2.4e-34 116.9 0.2 4e-34 116.1 0.1 1.4 1 0 0 1 1 1 1 YEATS family Osmo_CC PF08946.5 KOG97052.1 - 0.53 10.3 10.5 0.078 13.0 4.2 1.9 2 0 0 2 2 2 0 Osmosensory transporter coiled coil Syja_N PF02383.13 KOG97053.1 - 5.1e-94 314.6 1.1 7.9e-94 313.9 0.8 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 KOG97053.1 - 1.1e-26 94.2 0.2 2e-26 93.4 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HMGL-like PF00682.14 KOG97054.1 - 2e-77 260.0 0.0 2.9e-77 259.5 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 KOG97054.1 - 1e-25 90.0 0.6 1.9e-25 89.1 0.4 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain CGI-121 PF08617.5 KOG97054.1 - 0.091 12.4 0.8 0.2 11.3 0.0 1.9 2 0 0 2 2 2 0 Kinase binding protein CGI-121 bZIP_2 PF07716.10 KOG97055.1 - 0.0038 17.0 3.0 0.0038 17.0 2.1 2.5 2 0 0 2 2 2 1 Basic region leucine zipper Pex26 PF07163.7 KOG97055.1 - 0.064 12.1 0.2 0.064 12.1 0.1 2.2 2 1 1 3 3 3 0 Pex26 protein PspB PF06667.7 KOG97055.1 - 0.072 13.0 4.1 0.078 12.9 1.6 2.0 1 1 1 2 2 2 0 Phage shock protein B V_ATPase_I PF01496.14 KOG97055.1 - 9.7 3.9 9.9 15 3.2 6.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DNA_pol_B PF00136.16 KOG97056.1 - 1.1e-117 393.7 2.2 2.2e-117 392.6 1.5 1.5 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.5 KOG97056.1 - 4.1e-66 221.9 3.8 9.8e-66 220.6 2.6 1.7 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.14 KOG97056.1 - 1.6e-58 198.0 0.0 2.8e-58 197.3 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.3 KOG97056.1 - 4.5e-19 68.0 10.5 1.5e-18 66.3 7.3 2.0 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal Aa_trans PF01490.13 KOG97057.1 - 2.5e-107 358.9 37.1 2.9e-107 358.6 25.7 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ApoO PF09769.4 KOG97058.1 - 4.2e-06 26.5 0.4 0.55 9.9 0.0 3.2 3 0 0 3 3 3 3 Apolipoprotein O Y_phosphatase2 PF03162.8 KOG97059.1 - 3.6e-60 202.0 0.0 4.7e-60 201.6 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 KOG97059.1 - 1.3e-05 25.5 0.0 5.5e-05 23.4 0.0 1.8 1 1 1 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.15 KOG97059.1 - 0.02 14.5 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Upf2 PF04050.9 KOG97059.1 - 1.5 8.5 7.5 2.3 7.9 5.2 1.1 1 0 0 1 1 1 0 Up-frameshift suppressor 2 Myc_N PF01056.13 KOG97059.1 - 1.6 7.7 4.9 2.3 7.3 3.4 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Ras PF00071.17 KOG97060.1 - 2e-56 189.8 0.3 3.1e-56 189.2 0.2 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG97060.1 - 3.6e-19 69.4 0.2 9.8e-19 68.0 0.1 1.8 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 KOG97060.1 - 2.1e-10 40.1 0.1 3.1e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KOG97060.1 - 5.6e-07 29.1 0.3 2.2e-06 27.2 0.1 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOG97060.1 - 2e-05 24.5 0.0 4.7e-05 23.3 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOG97060.1 - 0.002 17.4 0.2 0.0039 16.4 0.1 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.12 KOG97060.1 - 0.26 10.7 3.5 0.94 8.9 0.1 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein ING PF12998.2 KOG97061.1 - 7.2e-24 84.0 0.3 7.2e-24 84.0 0.2 1.8 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 KOG97061.1 - 3.3e-09 36.2 7.9 5.6e-09 35.5 5.5 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 KOG97061.1 - 0.015 14.6 1.7 0.031 13.5 1.2 1.5 1 0 0 1 1 1 0 PHD-finger Macoilin PF09726.4 KOG97061.1 - 0.51 8.5 10.7 0.59 8.3 7.4 1.1 1 0 0 1 1 1 0 Transmembrane protein Herpes_BLLF1 PF05109.8 KOG97061.1 - 0.75 7.6 9.2 0.94 7.3 6.4 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) MDM1 PF15501.1 KOG97061.1 - 5.4 5.8 20.7 7.4 5.3 14.3 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 Ribosomal_S7e PF01251.13 KOG97062.1 - 3.8e-82 274.3 3.2 4.4e-82 274.1 2.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e DUF4265 PF14085.1 KOG97062.1 - 0.067 12.9 0.0 0.92 9.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4265) Mem_trans PF03547.13 KOG97063.1 - 1.3e-89 300.1 0.0 2.1e-89 299.5 0.0 1.3 1 1 0 1 1 1 1 Membrane transport protein DUF1183 PF06682.7 KOG97063.1 - 0.006 16.2 1.0 0.0097 15.5 0.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) PBP_sp32 PF07222.7 KOG97063.1 - 0.13 11.4 0.2 0.23 10.6 0.1 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF2183 PF09949.4 KOG97064.1 - 2e-32 111.0 0.1 8.7e-32 109.0 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) Ras PF00071.17 KOG97065.1 - 5.5e-56 188.4 0.1 6.6e-56 188.1 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG97065.1 - 8.3e-19 68.2 0.0 2.2e-18 66.8 0.0 1.7 2 1 0 2 2 2 1 Miro-like protein Arf PF00025.16 KOG97065.1 - 8.8e-18 64.1 0.0 1.1e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOG97065.1 - 1.7e-09 37.1 0.1 2.2e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOG97065.1 - 1e-06 28.3 0.0 2.1e-06 27.2 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOG97065.1 - 1.1e-05 25.3 0.0 1.9e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 KOG97065.1 - 0.049 13.6 0.0 0.13 12.2 0.0 1.7 2 1 0 2 2 2 0 AAA ATPase domain DUF258 PF03193.11 KOG97065.1 - 0.089 11.9 0.4 0.2 10.8 0.1 1.8 2 1 0 2 2 2 0 Protein of unknown function, DUF258 IIGP PF05049.8 KOG97065.1 - 0.1 11.4 0.0 0.15 10.8 0.0 1.3 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) N2227 PF07942.7 KOG97066.1 - 9.2e-94 313.3 0.0 1.7e-93 312.5 0.0 1.4 2 0 0 2 2 2 1 N2227-like protein Methyltransf_11 PF08241.7 KOG97066.1 - 0.0025 18.2 0.0 0.029 14.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOG97066.1 - 0.0026 17.4 0.0 0.0054 16.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOG97066.1 - 0.022 14.3 0.0 0.37 10.3 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.7 KOG97066.1 - 0.049 14.0 0.0 0.22 11.9 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.13 KOG97066.1 - 0.14 11.2 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family NST1 PF13945.1 KOG97067.1 - 3.1e-11 43.6 9.3 3.1e-11 43.6 6.4 5.3 3 2 2 5 5 5 1 Salt tolerance down-regulator FumaraseC_C PF10415.4 KOG97067.1 - 0.11 12.5 0.1 0.56 10.3 0.1 2.2 1 0 0 1 1 1 0 Fumarase C C-terminus Ras PF00071.17 KOG97068.1 - 3e-51 173.0 0.0 3.5e-51 172.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG97068.1 - 5.5e-14 52.6 0.0 8e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOG97068.1 - 1.5e-08 34.0 0.0 2.2e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.4 KOG97068.1 - 0.00066 19.1 0.0 1.2 8.5 0.0 2.5 3 0 0 3 3 3 2 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.5 KOG97068.1 - 0.025 13.7 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 KOG97068.1 - 0.097 12.6 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.1 KOG97068.1 - 0.11 12.4 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain DNA_topoisoIV PF00521.15 KOG97069.1 - 1.4e-122 409.6 0.6 2.8e-122 408.6 0.0 1.8 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 KOG97069.1 - 2.9e-33 114.5 3.5 6.3e-33 113.4 2.5 1.6 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.17 KOG97069.1 - 1.3e-12 47.5 0.1 6.9e-12 45.2 0.0 2.4 2 0 0 2 2 2 1 Toprim domain HATPase_c PF02518.21 KOG97069.1 - 1e-10 41.3 0.0 3.1e-10 39.7 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase C2 PF00168.25 KOG97070.1 - 2.4e-40 136.2 4.9 4e-12 45.8 0.1 4.7 4 0 0 4 4 4 4 C2 domain Snapin_Pallidin PF14712.1 KOG97071.1 - 3.9e-06 27.0 0.2 4.5e-06 26.8 0.2 1.1 1 0 0 1 1 1 1 Snapin/Pallidin YvrJ PF12841.2 KOG97071.1 - 0.12 11.6 0.4 4.4 6.6 0.0 2.7 2 1 0 2 2 2 0 YvrJ protein family Bacillus_HBL PF05791.6 KOG97071.1 - 0.14 11.5 0.4 1.1 8.6 0.3 1.9 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) FlaC_arch PF05377.6 KOG97071.1 - 0.15 11.9 0.1 1.3 8.9 0.0 2.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) MKT1_C PF12246.3 KOG97072.1 - 8.5e-71 237.7 4.6 1.7e-70 236.7 3.2 1.5 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.3 KOG97072.1 - 1.5e-30 105.3 0.4 9e-30 102.8 0.0 2.5 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.12 KOG97072.1 - 8.9e-28 96.5 0.0 3e-27 94.8 0.0 2.0 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 KOG97072.1 - 8.6e-11 41.7 0.0 2.2e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 XPG I-region EF-hand_4 PF12763.2 KOG97073.1 - 5.9e-51 170.5 8.4 3.5e-49 164.8 1.7 2.7 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand End3 PF12761.2 KOG97073.1 - 9.1e-24 84.1 11.3 7.5e-12 45.2 0.1 2.2 1 1 0 2 2 2 2 Actin cytoskeleton-regulatory complex protein END3 EF-hand_1 PF00036.27 KOG97073.1 - 0.00018 20.5 2.1 0.038 13.3 0.8 2.7 2 0 0 2 2 2 2 EF hand Erp_C PF06780.6 KOG97073.1 - 0.0034 17.2 6.3 0.0034 17.2 4.4 2.3 2 0 0 2 2 2 1 Erp protein C-terminus DUF3552 PF12072.3 KOG97073.1 - 0.013 14.7 3.2 0.02 14.0 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) EF-hand_8 PF13833.1 KOG97073.1 - 0.046 13.3 1.8 0.22 11.1 0.3 2.5 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.1 KOG97073.1 - 0.19 11.7 1.3 6.3 6.9 0.4 2.7 2 0 0 2 2 2 0 EF-hand domain IncA PF04156.9 KOG97073.1 - 0.33 10.5 4.0 0.52 9.8 2.8 1.3 1 0 0 1 1 1 0 IncA protein Mito_carr PF00153.22 KOG97074.1 - 4.8e-62 205.7 3.7 4.2e-20 71.2 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.1 KOG97074.1 - 7.5e-14 51.6 2.0 1e-08 35.1 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOG97074.1 - 2.1e-11 42.6 1.2 0.059 13.2 0.0 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.27 KOG97074.1 - 2.7e-11 41.9 1.3 0.024 13.9 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOG97074.1 - 8e-08 31.7 2.9 0.00039 19.9 0.2 3.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOG97074.1 - 3.5e-06 26.0 0.8 0.032 13.5 0.1 3.6 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.4 KOG97074.1 - 0.024 14.6 0.8 3.2 7.7 0.1 2.4 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DNA_mis_repair PF01119.14 KOG97075.1 - 6.3e-24 83.7 1.6 1.7e-23 82.3 0.4 2.2 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.6 KOG97075.1 - 6.7e-21 74.3 0.0 1.3e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.1 KOG97075.1 - 6.3e-13 48.5 0.0 2.3e-12 46.7 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOG97075.1 - 1.7e-11 43.7 0.0 3.8e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_S13 PF00416.17 KOG97076.1 - 2.4e-24 85.8 0.0 3.5e-24 85.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 KOG97076.1 - 0.0044 15.6 0.0 0.0044 15.6 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) IMS_HHH PF11798.3 KOG97076.1 - 0.025 14.6 0.1 0.14 12.2 0.0 2.1 2 0 0 2 2 2 0 IMS family HHH motif EOS1 PF12326.3 KOG97077.1 - 2.6e-73 244.5 0.7 5.3e-73 243.5 0.5 1.5 1 0 0 1 1 1 1 N-glycosylation protein BUD22 PF09073.5 KOG97077.1 - 9.5 5.1 8.6 5.8 5.8 4.5 1.6 2 0 0 2 2 2 0 BUD22 Tropomyosin_1 PF12718.2 KOG97078.1 - 3.9e-52 175.8 61.2 9.3e-35 119.5 26.9 2.0 1 1 1 2 2 2 2 Tropomyosin like Tropomyosin PF00261.15 KOG97078.1 - 1.6e-09 37.2 54.8 4.8e-05 22.5 19.1 2.1 1 1 1 2 2 2 2 Tropomyosin CENP-F_leu_zip PF10473.4 KOG97078.1 - 4.5e-06 26.5 58.9 1.1e-05 25.2 9.2 3.7 1 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KLRAQ PF10205.4 KOG97078.1 - 4.6e-06 26.6 37.8 0.054 13.5 8.2 3.1 1 1 2 3 3 3 3 Predicted coiled-coil domain-containing protein IFP_35_N PF07334.8 KOG97078.1 - 0.0013 18.6 14.9 0.0063 16.4 1.8 4.5 2 2 2 4 4 4 2 Interferon-induced 35 kDa protein (IFP 35) N-terminus ATG16 PF08614.6 KOG97078.1 - 0.003 17.4 47.9 0.16 11.8 16.0 3.1 1 1 2 3 3 3 2 Autophagy protein 16 (ATG16) Filament PF00038.16 KOG97078.1 - 0.0061 16.0 46.1 0.0081 15.6 31.9 1.3 1 0 0 1 1 1 1 Intermediate filament protein Myosin_tail_1 PF01576.14 KOG97078.1 - 0.02 12.6 52.7 0.38 8.4 26.6 2.0 1 1 1 2 2 2 0 Myosin tail ADIP PF11559.3 KOG97078.1 - 0.022 14.6 50.6 0.9 9.4 8.8 3.6 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding GAS PF13851.1 KOG97078.1 - 0.024 13.8 53.2 0.37 9.9 13.4 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4201 PF13870.1 KOG97078.1 - 0.037 13.4 46.3 0.32 10.4 20.8 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) APG6 PF04111.7 KOG97078.1 - 0.04 12.9 56.9 0.3 10.0 20.2 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF4200 PF13863.1 KOG97078.1 - 0.042 13.8 56.5 0.15 12.0 20.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Rootletin PF15035.1 KOG97078.1 - 0.057 13.3 50.8 0.14 12.1 8.0 3.2 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion Laminin_II PF06009.7 KOG97078.1 - 0.087 12.5 33.9 0.66 9.7 6.9 3.0 1 1 2 3 3 3 0 Laminin Domain II bZIP_1 PF00170.16 KOG97078.1 - 0.092 12.7 52.2 0.13 12.2 3.4 5.4 2 1 3 5 5 5 0 bZIP transcription factor TMF_DNA_bd PF12329.3 KOG97078.1 - 0.18 11.6 67.6 0.2 11.4 7.9 4.5 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF3584 PF12128.3 KOG97078.1 - 0.23 8.7 43.5 0.26 8.5 30.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) BLOC1_2 PF10046.4 KOG97078.1 - 0.34 11.0 41.2 3.3 7.8 5.2 4.1 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Mnd1 PF03962.10 KOG97078.1 - 0.41 10.3 48.5 0.68 9.5 14.8 2.6 1 1 2 3 3 3 0 Mnd1 family DUF3287 PF11690.3 KOG97078.1 - 0.44 10.6 17.8 0.053 13.5 3.7 3.1 1 1 1 3 3 3 0 Protein of unknown function (DUF3287) WXG100 PF06013.7 KOG97078.1 - 0.48 10.4 20.1 0.21 11.6 0.4 4.4 2 1 0 3 3 3 0 Proteins of 100 residues with WXG DUF3450 PF11932.3 KOG97078.1 - 0.52 9.5 41.2 4 6.6 7.6 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) IncA PF04156.9 KOG97078.1 - 0.67 9.5 56.1 8.7 5.8 23.7 2.9 1 1 1 2 2 2 0 IncA protein Nup54 PF13874.1 KOG97078.1 - 0.72 9.5 32.2 0.27 10.9 5.9 3.0 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 DivIC PF04977.10 KOG97078.1 - 0.78 9.2 54.9 0.072 12.5 4.6 5.2 1 1 4 5 5 5 0 Septum formation initiator Reo_sigmaC PF04582.7 KOG97078.1 - 0.97 8.5 12.3 2 7.4 2.2 2.3 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Ax_dynein_light PF10211.4 KOG97078.1 - 0.98 9.2 51.1 0.88 9.3 9.8 3.2 1 1 1 3 3 3 0 Axonemal dynein light chain Mod_r PF07200.8 KOG97078.1 - 1.3 8.9 46.4 14 5.6 13.1 3.5 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein ERM PF00769.14 KOG97078.1 - 1.5 8.2 56.2 3.5 7.0 20.5 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family FUSC PF04632.7 KOG97078.1 - 1.9 6.8 5.7 2.1 6.6 3.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Fib_alpha PF08702.5 KOG97078.1 - 2.1 8.4 30.4 4.6 7.3 9.5 2.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Sec2p PF06428.6 KOG97078.1 - 2.2 8.1 47.8 0.16 11.8 10.5 4.1 1 1 3 4 4 4 0 GDP/GTP exchange factor Sec2p DivIVA PF05103.8 KOG97078.1 - 2.2 8.3 46.5 2.1 8.3 1.9 4.1 1 1 3 4 4 4 0 DivIVA protein EzrA PF06160.7 KOG97078.1 - 2.7 6.0 40.9 0.28 9.3 5.6 2.5 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF724 PF05266.9 KOG97078.1 - 2.7 7.5 43.6 2.9 7.4 14.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Atg14 PF10186.4 KOG97078.1 - 4.8 6.0 43.3 5.1 5.9 9.0 2.7 1 1 2 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3349 PF11829.3 KOG97078.1 - 4.9 7.6 7.9 1.1 9.6 1.8 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) DUF972 PF06156.8 KOG97078.1 - 5.2 7.4 43.5 13 6.2 11.4 3.7 1 1 1 2 2 1 0 Protein of unknown function (DUF972) DASH_Hsk3 PF08227.6 KOG97078.1 - 7.8 6.7 13.9 5 7.3 0.4 3.8 4 0 0 4 4 3 0 DASH complex subunit Hsk3 like CENP-K PF11802.3 KOG97078.1 - 8.7 5.4 34.3 0.035 13.3 6.3 2.3 1 1 1 2 2 1 0 Centromere-associated protein K DnaJ PF00226.26 KOG97080.1 - 3e-23 81.3 1.7 6.6e-23 80.2 1.2 1.6 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 KOG97080.1 - 6.7e-16 57.9 3.6 1.6e-13 50.2 0.0 2.9 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 KOG97080.1 - 3.7e-10 39.7 19.2 1.1e-09 38.2 13.3 1.9 1 0 0 1 1 1 1 DnaJ central domain TP53IP5 PF15331.1 KOG97080.1 - 8.7 6.1 7.7 0.5 10.2 1.3 1.8 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 DUF1752 PF08550.5 KOG97081.1 - 6.3e-11 41.6 0.1 1.7e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Brix PF04427.13 KOG97082.1 - 1.4e-46 158.6 0.3 1.8e-46 158.2 0.2 1.1 1 0 0 1 1 1 1 Brix domain Parvo_coat_N PF08398.5 KOG97082.1 - 0.037 13.8 0.1 0.089 12.5 0.0 1.6 1 0 0 1 1 1 0 Parvovirus coat protein VP1 Bromodomain PF00439.20 KOG97082.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Bromodomain tRNA-synt_2 PF00152.15 KOG97084.1 - 1.2e-69 234.7 1.0 1.7e-69 234.1 0.7 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 KOG97084.1 - 2.3e-08 33.5 0.5 1e-05 24.8 0.3 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.20 KOG97084.1 - 4.7e-08 32.7 0.0 9.5e-08 31.7 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.20 KOG97084.1 - 0.01 15.3 0.1 3.4 7.1 0.0 2.5 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) RNase_HII PF01351.13 KOG97085.1 - 1.7e-68 230.1 0.0 2.5e-68 229.6 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease HII Herpes_TK_C PF08465.5 KOG97085.1 - 0.12 11.8 0.1 0.3 10.6 0.1 1.6 1 0 0 1 1 1 0 Thymidine kinase from Herpesvirus C-terminal 2-oxoacid_dh PF00198.18 KOG97086.1 - 2.8e-73 246.0 0.8 3.8e-73 245.5 0.5 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 KOG97086.1 - 4.4e-17 61.4 0.1 8.2e-17 60.6 0.1 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 KOG97086.1 - 6.8e-17 60.8 0.4 1.5e-16 59.7 0.3 1.6 1 0 0 1 1 1 1 e3 binding domain L1R_F9L PF02442.12 KOG97086.1 - 0.051 13.0 3.6 0.083 12.3 0.4 2.2 2 0 0 2 2 2 0 Lipid membrane protein of large eukaryotic DNA viruses Tom7 PF08038.7 KOG97087.1 - 1.2e-18 66.2 0.1 1.6e-18 65.8 0.1 1.1 1 0 0 1 1 1 1 TOM7 family Ribosomal_L13 PF00572.13 KOG97088.1 - 3.6e-21 75.5 0.1 5.4e-21 74.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L13 MSP7_C PF12948.2 KOG97088.1 - 0.1 12.8 0.0 0.29 11.3 0.0 1.6 2 0 0 2 2 2 0 MSP7-like protein C-terminal domain Fork_head PF00250.13 KOG97089.1 - 3.9e-37 126.1 0.6 1e-36 124.8 0.4 1.7 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 KOG97089.1 - 4.7e-12 45.8 0.0 1.6e-11 44.1 0.0 2.0 1 0 0 1 1 1 1 FHA domain Ribosomal_L6 PF00347.18 KOG97090.1 - 3e-27 94.9 9.8 4.4e-14 52.7 2.4 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 SLS PF14611.1 KOG97090.1 - 0.041 13.3 0.2 0.058 12.7 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator LRR_6 PF13516.1 KOG97090.1 - 0.14 12.3 0.5 2 8.7 0.0 2.8 3 0 0 3 3 3 0 Leucine Rich repeat SUN PF03856.8 KOG97091.1 - 1e-106 355.7 14.4 1.7e-106 355.1 10.0 1.3 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) SOG2 PF10428.4 KOG97091.1 - 8.4 4.9 19.6 12 4.4 13.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein MFS_1 PF07690.11 KOG97092.1 - 5.3e-37 127.3 20.7 5.3e-37 127.3 14.4 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 KOG97092.1 - 0.0063 14.7 3.0 0.01 14.0 2.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3353 PF11833.3 KOG97092.1 - 1.1 8.6 2.9 2.8 7.3 2.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3353) DnaJ PF00226.26 KOG97093.1 - 1.5e-26 91.8 0.6 2.6e-26 91.1 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 KOG97093.1 - 1.4e-19 69.8 0.6 8.4e-17 60.8 0.0 2.5 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 KOG97093.1 - 7.4e-14 51.5 19.1 1.3e-13 50.8 13.3 1.4 1 0 0 1 1 1 1 DnaJ central domain Cytochrom_c3_2 PF14537.1 KOG97093.1 - 0.056 13.7 3.8 0.86 9.9 0.4 2.6 2 0 0 2 2 2 0 Cytochrome c3 HypA PF01155.14 KOG97093.1 - 0.084 12.5 10.6 0.44 10.2 1.4 2.3 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Methyltransf_26 PF13659.1 KOG97094.1 - 1.7e-09 37.7 0.0 2.6e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOG97094.1 - 4.5e-09 35.9 0.0 6.8e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 KOG97094.1 - 8e-09 35.2 0.0 1.1e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOG97094.1 - 2.1e-05 25.0 0.0 3.3e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOG97094.1 - 0.0014 18.9 0.0 0.0022 18.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOG97094.1 - 0.017 14.2 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.7 KOG97094.1 - 0.036 14.5 0.0 0.067 13.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 KOG97094.1 - 0.098 11.6 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Met_10 PF02475.11 KOG97094.1 - 0.1 12.2 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein TRM PF02005.11 KOG97094.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Gcd10p PF04189.8 KOG97095.1 - 6.9e-105 350.4 5.2 8.4e-105 350.1 3.6 1.1 1 0 0 1 1 1 1 Gcd10p family Nol1_Nop2_Fmu PF01189.12 KOG97096.1 - 1.6e-109 365.6 0.0 2.6e-109 364.9 0.0 1.3 1 0 0 1 1 1 1 NOL1/NOP2/sun family Met_10 PF02475.11 KOG97096.1 - 0.0013 18.3 0.5 0.0042 16.6 0.0 1.9 2 0 0 2 2 2 1 Met-10+ like-protein FtsJ PF01728.14 KOG97096.1 - 0.0026 17.7 0.0 0.0059 16.6 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.1 KOG97096.1 - 0.0076 15.8 0.0 0.015 14.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Actin PF00022.14 KOG97097.1 - 4e-54 183.5 0.0 1.6e-32 112.4 0.0 2.3 2 0 0 2 2 2 2 Actin Atrophin-1 PF03154.10 KOG97097.1 - 3.3 5.7 9.6 5.3 5.0 6.6 1.4 1 0 0 1 1 1 0 Atrophin-1 family Y_phosphatase2 PF03162.8 KOG97099.1 - 5.2e-58 195.0 0.0 6.3e-58 194.7 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 KOG97099.1 - 3.1e-05 24.2 0.0 5.4e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 KOG97099.1 - 0.041 13.2 0.0 0.051 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DSPc PF00782.15 KOG97099.1 - 0.054 13.0 0.0 0.07 12.7 0.0 1.2 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Porin_3 PF01459.17 KOG97100.1 - 5.1e-59 199.8 0.8 5.7e-59 199.6 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic porin Vac7 PF12751.2 KOG97101.1 - 6.4e-21 74.6 10.0 6e-14 51.6 0.4 4.6 3 2 1 4 4 4 2 Vacuolar segregation subunit 7 DUF3493 PF11998.3 KOG97101.1 - 0.17 11.8 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3493) DSPc PF00782.15 KOG97102.1 - 1.1e-36 125.4 0.0 1.7e-36 124.7 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOG97102.1 - 3.9e-05 23.0 0.0 6.3e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 KOG97102.1 - 0.041 13.9 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate COX4 PF02936.9 KOG97103.1 - 2.6e-44 150.4 0.7 2.9e-44 150.2 0.5 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV N1221 PF07923.8 KOG97103.1 - 0.067 12.0 0.1 0.071 11.9 0.0 1.1 1 0 0 1 1 1 0 N1221-like protein DUF1289 PF06945.8 KOG97103.1 - 0.22 11.0 4.7 0.66 9.4 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1289) COG5 PF10392.4 KOG97104.1 - 2e-41 141.0 4.3 2e-41 141.0 3.0 2.2 2 1 1 3 3 3 1 Golgi transport complex subunit 5 DUF2011 PF09428.5 KOG97105.1 - 2.6e-32 111.4 15.1 3.1e-32 111.2 10.5 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) DUF4508 PF14969.1 KOG97105.1 - 0.096 12.6 0.6 0.18 11.8 0.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4508) DUF2532 PF10811.3 KOG97105.1 - 0.91 9.3 7.3 0.092 12.5 1.2 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2532) Sec23_trunk PF04811.10 KOG97106.1 - 1.9e-65 220.6 0.1 9.4e-65 218.3 0.0 2.2 3 0 0 3 3 3 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 KOG97106.1 - 3.3e-21 74.6 0.7 3.3e-21 74.6 0.5 2.3 3 0 0 3 3 3 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.10 KOG97106.1 - 5.1e-18 64.3 5.2 9.2e-18 63.5 3.6 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.7 KOG97106.1 - 8.6e-18 64.6 0.1 2.6e-17 63.1 0.1 1.9 2 0 0 2 2 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 KOG97106.1 - 3.4e-09 36.2 0.0 7.1e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Zn_Tnp_IS1595 PF12760.2 KOG97106.1 - 0.32 10.8 1.9 0.64 9.8 1.3 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Sigma70_ner PF04546.8 KOG97106.1 - 0.33 10.5 6.3 0.68 9.5 4.4 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region CDC45 PF02724.9 KOG97106.1 - 4.2 5.2 9.2 6.6 4.6 6.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Nucleoplasmin PF03066.10 KOG97106.1 - 4.3 6.8 16.1 10 5.6 11.2 1.6 1 0 0 1 1 1 0 Nucleoplasmin RXT2_N PF08595.6 KOG97106.1 - 4.5 7.0 6.7 12 5.6 4.6 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal Nop14 PF04147.7 KOG97106.1 - 5 4.9 14.6 8.2 4.2 10.2 1.2 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.7 KOG97106.1 - 6.9 5.7 15.8 15 4.6 10.9 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Glycos_transf_1 PF00534.15 KOG97107.1 - 8.1e-18 64.4 0.0 1.3e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 KOG97107.1 - 0.0054 16.4 0.0 0.014 15.1 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.1 KOG97107.1 - 0.065 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 PH PF00169.24 KOG97108.1 - 1.6e-15 57.1 3.2 1.9e-15 56.9 0.2 2.6 2 0 0 2 2 2 1 PH domain DUF2614 PF11023.3 KOG97109.1 - 0.13 12.0 1.0 0.2 11.4 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2614) Peptidase_M1 PF01433.15 KOG97110.1 - 2.4e-85 287.0 0.1 3.4e-85 286.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.6 KOG97110.1 - 1.4e-47 160.8 0.9 2.6e-47 159.9 0.6 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.1 KOG97110.1 - 5.1e-16 58.8 0.0 8.7e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily ATG11 PF10377.4 KOG97110.1 - 0.017 14.9 0.3 0.041 13.7 0.2 1.6 1 0 0 1 1 1 0 Autophagy-related protein 11 Peptidase_M61 PF05299.7 KOG97110.1 - 0.27 11.1 2.1 1.6 8.7 1.4 2.2 1 1 0 1 1 1 0 M61 glycyl aminopeptidase PRA1 PF03208.14 KOG97111.1 - 1.2e-39 135.1 0.5 1.4e-39 134.9 0.4 1.1 1 0 0 1 1 1 1 PRA1 family protein DUF2722 PF10846.3 KOG97112.1 - 1.9e-82 277.5 30.3 2.1e-82 277.3 21.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Bt_P21 PF05560.6 KOG97112.1 - 0.0037 16.6 1.1 0.006 15.9 0.7 1.2 1 0 0 1 1 1 1 Bacillus thuringiensis P21 molecular chaperone protein COG6 PF06419.6 KOG97113.1 - 2.1e-168 561.2 29.0 2.1e-168 561.2 20.1 1.4 2 0 0 2 2 2 1 Conserved oligomeric complex COG6 zf-AD PF07776.10 KOG97113.1 - 0.016 15.2 0.5 0.15 12.0 0.0 2.9 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) Fic_N PF13784.1 KOG97113.1 - 0.029 14.2 0.1 0.13 12.1 0.1 2.1 1 0 0 1 1 1 0 Fic/DOC family N-terminal Pro_CA PF00484.14 KOG97114.1 - 8.5e-37 126.5 0.2 1.1e-36 126.1 0.1 1.1 1 0 0 1 1 1 1 Carbonic anhydrase Iso_dh PF00180.15 KOG97115.1 - 3.9e-75 252.9 0.2 4.4e-75 252.7 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PIG-H PF10181.4 KOG97116.1 - 6.5e-21 73.7 0.3 1.5e-20 72.5 0.2 1.6 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component Myb_DNA-binding PF00249.26 KOG97117.1 - 2.1e-05 24.4 0.1 8.2e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain tRNA_SAD PF07973.9 KOG97118.1 - 1.3e-08 34.5 0.3 4.8e-08 32.7 0.1 2.1 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.14 KOG97118.1 - 0.00074 17.9 0.1 0.0011 17.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) BNR PF02012.15 KOG97119.1 - 1.1e-07 30.5 8.1 0.53 10.3 0.1 5.9 6 0 0 6 6 6 4 BNR/Asp-box repeat BNR_2 PF13088.1 KOG97119.1 - 3.8e-07 29.6 2.8 0.0051 16.1 0.1 3.2 1 1 2 3 3 3 3 BNR repeat-like domain Mo-co_dimer PF03404.11 KOG97119.1 - 0.012 15.2 1.4 6.5 6.3 0.0 3.2 3 0 0 3 3 3 0 Mo-co oxidoreductase dimerisation domain Exo_endo_phos PF03372.18 KOG97120.1 - 1.2e-17 64.6 0.0 1.9e-17 64.0 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 KOG97120.1 - 1.9e-12 46.8 0.0 1e-10 41.2 0.0 2.4 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase zf-GRF PF06839.7 KOG97120.1 - 3.4e-09 36.4 0.3 7.7e-09 35.3 0.2 1.7 1 0 0 1 1 1 1 GRF zinc finger EamA PF00892.15 KOG97121.1 - 0.13 12.3 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 EamA-like transporter family WD40 PF00400.27 KOG97122.1 - 2.3e-13 49.4 3.5 1.3e-05 24.8 0.2 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat Y_phosphatase2 PF03162.8 KOG97126.1 - 1.4e-65 219.6 0.0 2.1e-65 219.1 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 KOG97126.1 - 2.1e-07 31.3 0.0 4.8e-07 30.1 0.0 1.6 2 0 0 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.15 KOG97126.1 - 0.0018 17.8 0.0 0.0055 16.2 0.0 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOG97126.1 - 0.0042 16.4 0.0 0.0067 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase TMEM192 PF14802.1 KOG97126.1 - 0.048 12.4 0.2 3.3 6.4 0.0 2.3 2 0 0 2 2 2 0 TMEM192 family Histone PF00125.19 KOG97127.1 - 5.2e-30 103.3 0.7 8.5e-30 102.7 0.5 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KOG97127.1 - 9.4e-07 28.9 0.0 1.4e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 KOG97127.1 - 0.002 18.1 1.0 0.0025 17.8 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 KOG97127.1 - 0.058 13.1 0.1 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Histone PF00125.19 KOG97128.1 - 7.9e-15 54.7 0.2 9.6e-15 54.4 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KOG97128.1 - 7e-05 22.9 0.1 9.7e-05 22.4 0.0 1.4 1 1 0 1 1 1 1 Kinetochore component CENP-S TAF PF02969.12 KOG97128.1 - 8.3e-05 22.4 0.1 0.00012 21.9 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.18 KOG97128.1 - 0.00018 21.4 0.1 0.00032 20.6 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T PF15511.1 KOG97128.1 - 0.0021 17.3 0.0 0.0022 17.2 0.0 1.0 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T Bromo_TP PF07524.8 KOG97128.1 - 0.024 14.3 0.0 0.029 14.0 0.0 1.3 1 1 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.8 KOG97128.1 - 0.06 13.6 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Glyco_transf_15 PF01793.11 KOG97129.1 - 4.5e-126 420.2 15.6 6.3e-126 419.7 10.8 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase zf-C2H2 PF00096.21 KOG97130.1 - 1.9e-13 49.8 10.7 5.3e-07 29.5 0.7 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG97130.1 - 1.6e-12 46.8 7.4 4.7e-05 23.4 0.4 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KOG97130.1 - 2.5e-12 46.4 12.4 9.1e-08 32.0 0.1 4.0 4 0 0 4 4 4 3 Zinc-finger double domain zf-met PF12874.2 KOG97130.1 - 7.2e-06 26.0 3.9 0.00065 19.8 0.2 3.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KOG97130.1 - 1e-05 25.4 7.3 0.0055 16.8 0.2 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding Zn_ribbon_recom PF13408.1 KOG97130.1 - 5.5e-05 23.3 5.6 7.8e-05 22.8 1.4 2.5 2 0 0 2 2 2 1 Recombinase zinc beta ribbon domain zf-Di19 PF05605.7 KOG97130.1 - 0.052 13.6 1.1 0.13 12.4 0.7 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.10 KOG97130.1 - 0.056 13.2 3.8 0.43 10.3 0.3 2.8 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_6 PF13912.1 KOG97130.1 - 0.079 12.8 5.9 8 6.5 0.2 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger FYVE PF01363.16 KOG97130.1 - 1.8 8.5 5.4 3.9 7.4 3.7 1.5 1 0 0 1 1 1 0 FYVE zinc finger Bac_surface_Ag PF01103.18 KOG97131.1 - 3.7e-48 164.6 0.7 4.8e-48 164.2 0.5 1.1 1 0 0 1 1 1 1 Surface antigen Cyclin_N PF00134.18 KOG97132.1 - 1.7e-17 63.1 0.8 1.2e-16 60.4 0.2 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 KOG97132.1 - 0.052 13.4 3.7 0.84 9.5 0.0 3.3 3 0 0 3 3 3 0 Cyclin, C-terminal domain DUF1242 PF06842.7 KOG97133.1 - 6.9e-19 67.0 0.4 9.4e-19 66.6 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Methyltransf_16 PF10294.4 KOG97134.1 - 3.8e-49 166.4 0.0 5.4e-49 165.9 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 KOG97134.1 - 0.011 15.0 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.2 KOG97134.1 - 0.043 14.3 0.0 0.066 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain T4_Gp59_N PF08993.5 KOG97134.1 - 0.11 12.5 1.8 0.27 11.2 1.3 1.6 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase R3H PF01424.17 KOG97135.1 - 1.6e-11 43.7 0.1 3.1e-11 42.7 0.1 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.12 KOG97135.1 - 4.9e-08 32.7 80.7 0.00011 22.0 12.1 13.7 14 2 0 14 14 14 6 NF-X1 type zinc finger Nol1_Nop2_Fmu PF01189.12 KOG97136.1 - 7.6e-14 51.7 0.1 1.9e-12 47.1 0.0 2.4 2 1 0 2 2 2 1 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 KOG97136.1 - 0.00058 19.8 0.0 0.0024 17.8 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.5 KOG97136.1 - 0.045 13.3 0.0 0.091 12.3 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Hist_deacetyl PF00850.14 KOG97137.1 - 4.3e-94 315.2 0.0 5.9e-94 314.8 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Arb2 PF09757.4 KOG97137.1 - 8.5e-51 171.8 0.2 1.4e-50 171.2 0.1 1.3 1 0 0 1 1 1 1 Arb2 domain Pkinase PF00069.20 KOG97138.1 - 1.2e-38 132.7 0.0 2e-38 132.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97138.1 - 5.1e-29 101.1 0.0 7.1e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG97138.1 - 0.0013 17.7 0.0 0.0032 16.4 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 KOG97138.1 - 0.0077 15.9 0.0 0.56 9.8 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family RRM_1 PF00076.17 KOG97141.1 - 2.7e-59 196.7 0.4 3.7e-20 71.3 0.2 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG97141.1 - 4.9e-31 106.5 0.2 1e-10 41.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG97141.1 - 4.2e-29 100.1 0.9 1.8e-09 37.2 0.3 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KOG97141.1 - 6.2e-06 25.8 0.4 0.0075 16.0 0.0 3.1 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 KOG97141.1 - 0.00046 19.8 0.1 0.0011 18.6 0.0 1.7 1 0 0 1 1 1 1 Limkain b1 DUF3421 PF11901.3 KOG97141.1 - 0.02 14.6 0.0 3.9 7.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3421) Inhibitor_I9 PF05922.11 KOG97142.1 - 0.00015 22.2 0.2 0.00022 21.7 0.2 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 SpoV PF08183.6 KOG97142.1 - 0.049 13.3 0.1 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Stage V sporulation protein family DUF3887 PF13026.1 KOG97142.1 - 0.11 12.7 0.8 0.13 12.5 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3887) ABC_tran PF00005.22 KOG97143.1 - 2.3e-45 154.2 0.2 7.6e-23 81.3 0.0 4.4 3 2 0 3 3 2 2 ABC transporter AAA_21 PF13304.1 KOG97143.1 - 1.8e-15 57.6 0.6 0.00037 20.5 0.0 4.4 3 1 0 3 3 3 3 AAA domain SMC_N PF02463.14 KOG97143.1 - 4.9e-14 52.0 0.0 8.1e-06 25.2 0.0 3.9 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 KOG97143.1 - 4.1e-10 39.9 0.0 0.00043 20.4 0.0 4.3 5 1 0 5 5 3 2 AAA domain AAA_29 PF13555.1 KOG97143.1 - 6.1e-09 35.2 0.5 0.0012 18.3 0.0 2.7 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 KOG97143.1 - 1.1e-07 32.4 1.0 0.005 17.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.1 KOG97143.1 - 1.8e-07 31.9 0.1 0.0058 17.4 0.0 3.1 3 0 0 3 3 2 2 AAA domain DUF258 PF03193.11 KOG97143.1 - 2.2e-07 30.1 0.0 0.00065 18.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Dynamin_N PF00350.18 KOG97143.1 - 4.7e-07 29.7 0.0 1e-05 25.4 0.0 2.9 2 0 0 2 2 2 1 Dynamin family AAA_28 PF13521.1 KOG97143.1 - 1.2e-06 28.5 0.0 0.0087 16.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 KOG97143.1 - 2.3e-06 27.5 0.0 0.084 12.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 KOG97143.1 - 4.8e-06 26.3 0.0 0.012 15.5 0.0 3.0 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.18 KOG97143.1 - 6.9e-06 26.0 0.0 0.0054 16.6 0.0 3.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_10 PF12846.2 KOG97143.1 - 1e-05 25.1 0.1 0.24 10.7 0.0 3.6 4 0 0 4 4 4 2 AAA-like domain Miro PF08477.8 KOG97143.1 - 1.1e-05 25.8 0.0 0.042 14.3 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein RNA_helicase PF00910.17 KOG97143.1 - 1.4e-05 25.2 0.0 0.11 12.6 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA PF00004.24 KOG97143.1 - 1.7e-05 25.0 0.1 0.83 9.8 0.0 4.2 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 KOG97143.1 - 2.5e-05 24.6 0.1 0.021 15.1 0.0 3.2 3 0 0 3 3 2 1 AAA domain MobB PF03205.9 KOG97143.1 - 3.1e-05 23.7 0.2 0.34 10.6 0.0 3.1 3 0 0 3 3 2 2 Molybdopterin guanine dinucleotide synthesis protein B Arch_ATPase PF01637.13 KOG97143.1 - 3.8e-05 23.5 0.0 0.34 10.5 0.0 3.5 3 0 0 3 3 3 1 Archaeal ATPase AAA_16 PF13191.1 KOG97143.1 - 6.4e-05 23.0 1.2 0.26 11.2 0.0 4.4 5 0 0 5 5 5 1 AAA ATPase domain AAA_14 PF13173.1 KOG97143.1 - 6.5e-05 22.8 0.0 2.5 8.0 0.0 4.0 4 0 0 4 4 3 2 AAA domain ArgK PF03308.11 KOG97143.1 - 9.4e-05 21.3 0.1 0.25 10.0 0.0 2.5 2 0 0 2 2 2 2 ArgK protein MutS_V PF00488.16 KOG97143.1 - 0.00026 20.4 0.1 0.15 11.4 0.0 2.5 2 0 0 2 2 2 1 MutS domain V DUF87 PF01935.12 KOG97143.1 - 0.00059 19.7 0.1 0.32 10.7 0.0 4.0 3 0 0 3 3 3 1 Domain of unknown function DUF87 NACHT PF05729.7 KOG97143.1 - 0.0012 18.5 0.0 0.69 9.5 0.0 2.7 3 0 0 3 3 2 1 NACHT domain PduV-EutP PF10662.4 KOG97143.1 - 0.0015 18.0 0.0 0.36 10.3 0.0 3.6 4 0 0 4 4 3 1 Ethanolamine utilisation - propanediol utilisation HEAT_2 PF13646.1 KOG97143.1 - 0.0021 18.2 0.1 0.17 12.1 0.0 3.3 2 2 1 3 3 3 1 HEAT repeats AAA_13 PF13166.1 KOG97143.1 - 0.0036 15.8 3.8 2.5 6.4 0.0 4.0 4 1 0 4 4 4 1 AAA domain ParcG PF10274.4 KOG97143.1 - 0.0045 16.9 0.4 1.1 9.0 0.0 2.9 2 1 0 2 2 2 1 Parkin co-regulated protein AAA_30 PF13604.1 KOG97143.1 - 0.005 16.4 0.1 5.7 6.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain Adaptin_N PF01602.15 KOG97143.1 - 0.0065 14.8 0.8 0.028 12.7 0.5 1.9 1 1 0 1 1 1 1 Adaptin N terminal region cobW PF02492.14 KOG97143.1 - 0.0093 15.4 0.0 5.8 6.3 0.0 3.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP-synt_ab PF00006.20 KOG97143.1 - 0.011 15.2 0.0 8.2 5.8 0.0 3.1 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_25 PF13481.1 KOG97143.1 - 0.014 14.8 0.0 3.1 7.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain Septin PF00735.13 KOG97143.1 - 0.016 14.2 0.0 1.2 8.0 0.0 2.6 2 0 0 2 2 2 0 Septin T2SE PF00437.15 KOG97143.1 - 0.021 13.7 0.0 0.31 9.8 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Ecm29 PF13001.2 KOG97143.1 - 0.022 13.2 0.2 0.13 10.7 0.0 2.0 2 0 0 2 2 2 0 Proteasome stabiliser ATP_bind_1 PF03029.12 KOG97143.1 - 0.048 13.2 0.3 7.8 5.9 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MMS19_C PF12460.3 KOG97143.1 - 0.048 12.3 0.1 6 5.4 0.0 3.1 2 2 1 3 3 3 0 RNAPII transcription regulator C-terminal Mg_chelatase PF01078.16 KOG97143.1 - 0.059 12.5 0.2 1.2 8.2 0.0 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI CLASP_N PF12348.3 KOG97143.1 - 0.073 12.4 0.2 4.5 6.5 0.0 2.7 2 1 0 3 3 2 0 CLASP N terminal HEAT_EZ PF13513.1 KOG97143.1 - 0.19 12.2 4.2 23 5.6 0.0 4.8 4 2 2 6 6 5 0 HEAT-like repeat FtsK_SpoIIIE PF01580.13 KOG97143.1 - 0.19 11.1 1.2 1.3 8.4 0.0 2.6 3 0 0 3 3 2 0 FtsK/SpoIIIE family UPF0052 PF01933.13 KOG97144.1 - 1.9e-81 273.7 0.0 3.6e-81 272.7 0.0 1.4 1 1 0 1 1 1 1 Uncharacterised protein family UPF0052 DUF3842 PF12953.2 KOG97144.1 - 0.091 12.9 0.1 0.19 11.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3842) HAD PF12710.2 KOG97145.1 - 3.4e-15 56.7 0.0 4.5e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 KOG97145.1 - 2e-06 27.1 0.0 3.5e-06 26.3 0.0 1.4 1 1 0 1 1 1 1 Putative Phosphatase HAD_2 PF13419.1 KOG97145.1 - 0.0001 22.6 0.1 0.0017 18.6 0.0 2.5 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase UMPH-1 PF05822.7 KOG97145.1 - 0.00036 19.9 0.0 0.00064 19.1 0.0 1.5 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Hydrolase PF00702.21 KOG97145.1 - 0.1 12.9 0.6 1.6 9.1 0.0 2.6 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase Iso_dh PF00180.15 KOG97146.1 - 3.9e-70 236.5 0.0 4.5e-70 236.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase zf-C3HC4_3 PF13920.1 KOG97147.1 - 3.6e-06 26.5 6.0 6.6e-06 25.6 4.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOG97147.1 - 8 6.5 11.1 18 5.4 7.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CTDII PF01556.13 KOG97148.1 - 6e-24 83.7 0.3 2.6e-20 72.1 0.0 2.7 2 1 0 2 2 2 2 DnaJ C terminal domain DnaJ PF00226.26 KOG97148.1 - 9.2e-24 82.9 0.5 1.5e-23 82.2 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain Fork_head_N PF08430.7 KOG97148.1 - 0.85 10.0 12.3 1.8 8.9 8.5 1.5 1 0 0 1 1 1 0 Forkhead N-terminal region WD40 PF00400.27 KOG97149.1 - 1.1e-50 167.7 15.7 8.4e-12 44.5 0.0 7.6 8 0 0 8 8 8 6 WD domain, G-beta repeat Nup160 PF11715.3 KOG97149.1 - 1.6e-10 39.7 12.8 0.0083 14.3 0.2 5.0 2 1 3 5 5 5 5 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 KOG97149.1 - 5.6e-07 28.6 3.2 0.12 11.0 0.1 3.9 1 1 3 4 4 4 3 Nup133 N terminal like Nbas_N PF15492.1 KOG97149.1 - 0.0005 19.2 0.6 0.69 8.9 0.1 2.9 2 1 0 2 2 2 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.11 KOG97149.1 - 0.003 15.8 0.0 1 7.5 0.0 2.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain Hira PF07569.6 KOG97149.1 - 0.0032 16.7 0.3 2 7.5 0.0 3.7 2 1 2 4 4 4 1 TUP1-like enhancer of split DUF3312 PF11768.3 KOG97149.1 - 0.0059 14.8 0.0 0.011 13.9 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3312) Coatomer_WDAD PF04053.9 KOG97149.1 - 0.016 14.0 0.0 0.04 12.7 0.0 1.6 1 1 1 2 2 2 0 Coatomer WD associated region Ribosomal_L27 PF01016.14 KOG97150.1 - 5e-31 106.3 0.1 8.4e-31 105.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal L27 protein RRM_1 PF00076.17 KOG97151.1 - 5e-55 183.0 0.3 1.1e-19 69.8 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG97151.1 - 1.8e-34 117.4 0.1 5.7e-13 48.6 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG97151.1 - 1.2e-19 69.8 0.1 2.2e-08 33.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Smg4_UPF3 PF03467.10 KOG97151.1 - 0.0024 17.8 0.0 2.1 8.3 0.0 2.3 2 0 0 2 2 2 2 Smg-4/UPF3 family Mito_carr PF00153.22 KOG97152.1 - 8.5e-54 179.2 5.4 1.3e-20 72.8 0.1 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF4126 PF13548.1 KOG97152.1 - 0.044 13.2 0.2 0.086 12.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4126) Ribosomal_L30 PF00327.15 KOG97153.1 - 1.6e-14 53.2 1.1 4.3e-14 51.8 0.8 1.8 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e DNA_pol_viral_C PF00336.13 KOG97153.1 - 0.035 13.3 0.0 0.059 12.6 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain eRF1_2 PF03464.10 KOG97154.1 - 4.2e-32 111.2 0.6 7.1e-32 110.5 0.4 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 KOG97154.1 - 1e-24 86.9 0.1 3.8e-24 85.1 0.0 2.1 2 0 0 2 2 2 1 eRF1 domain 3 eRF1_1 PF03463.10 KOG97154.1 - 1.8e-11 43.7 0.3 3.1e-11 42.9 0.2 1.4 1 0 0 1 1 1 1 eRF1 domain 1 RNA12 PF10443.4 KOG97154.1 - 0.0067 14.9 0.1 0.0077 14.7 0.1 1.3 1 0 0 1 1 1 1 RNA12 protein DUF4354 PF14263.1 KOG97154.1 - 0.081 12.6 2.3 0.094 12.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4354) Citrate_synt PF00285.16 KOG97155.1 - 6.1e-101 337.6 0.0 7.5e-101 337.3 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase Grp1_Fun34_YaaH PF01184.14 KOG97156.1 - 3e-94 314.1 16.4 3.6e-94 313.9 11.3 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family RNA_pol_Rpc34 PF05158.7 KOG97157.1 - 2.2e-102 342.5 2.2 2.7e-102 342.3 1.5 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit B-block_TFIIIC PF04182.7 KOG97157.1 - 0.0034 17.2 2.3 0.14 12.0 0.1 2.4 1 1 1 2 2 2 2 B-block binding subunit of TFIIIC Rrf2 PF02082.15 KOG97157.1 - 0.0063 16.6 1.2 0.023 14.7 0.1 2.2 2 0 0 2 2 2 1 Transcriptional regulator HTH_36 PF13730.1 KOG97157.1 - 0.011 15.8 0.4 1.4 9.1 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain UPF0262 PF06793.7 KOG97158.1 - 0.013 15.2 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0262) DUF2373 PF10180.4 KOG97158.1 - 0.094 12.2 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) VHS PF00790.14 KOG97159.1 - 1.1e-41 141.7 0.1 2.4e-41 140.6 0.0 1.6 1 0 0 1 1 1 1 VHS domain FYVE PF01363.16 KOG97159.1 - 2.6e-19 68.8 2.1 6.2e-19 67.6 1.5 1.6 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.11 KOG97159.1 - 0.0011 18.8 1.7 0.0011 18.8 1.2 2.1 2 0 0 2 2 2 1 FYVE-type zinc finger UIM PF02809.15 KOG97159.1 - 0.0042 16.5 11.6 0.11 12.1 1.2 3.6 2 0 0 2 2 2 2 Ubiquitin interaction motif Tis11B_N PF04553.7 KOG97159.1 - 0.05 13.7 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 Tis11B like protein, N terminus zf-AN1 PF01428.11 KOG97159.1 - 0.88 9.5 14.6 0.051 13.4 6.2 1.9 2 0 0 2 2 2 0 AN1-like Zinc finger zf-RING_5 PF14634.1 KOG97159.1 - 6.5 6.5 11.5 81 3.0 8.0 2.4 1 1 0 1 1 1 0 zinc-RING finger domain Autophagy_N PF03986.8 KOG97160.1 - 1.1e-43 148.4 1.1 1.1e-43 148.4 0.8 1.8 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.10 KOG97160.1 - 9.1e-22 77.0 0.1 2.5e-21 75.6 0.1 1.8 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 KOG97160.1 - 1.1e-13 50.0 2.8 1.9e-13 49.2 1.9 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal LCAT PF02450.10 KOG97161.1 - 9.3e-149 495.6 0.2 1.1e-148 495.3 0.1 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_1 PF00561.15 KOG97161.1 - 0.00061 19.4 0.0 0.0091 15.5 0.0 2.6 3 0 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOG97161.1 - 0.0023 17.7 0.0 0.0055 16.4 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1749 PF08538.5 KOG97161.1 - 0.023 13.5 0.0 0.038 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Whi5 PF08528.6 KOG97162.1 - 8.2e-11 41.2 3.0 1.6e-10 40.2 2.0 1.5 1 0 0 1 1 1 1 Whi5 like Pox_polyA_pol_C PF12629.2 KOG97162.1 - 0.092 12.4 0.6 0.16 11.6 0.4 1.4 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase C-terminal domain Med9 PF07544.8 KOG97163.1 - 1.1e-25 89.1 0.8 1.1e-25 89.1 0.6 1.6 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 UBN2 PF14223.1 KOG97163.1 - 0.034 13.9 0.2 0.049 13.4 0.1 1.3 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Syntaxin PF00804.20 KOG97163.1 - 0.46 10.6 7.9 0.94 9.6 4.8 1.9 1 1 1 2 2 2 0 Syntaxin HA2 PF04408.18 KOG97164.1 - 1.4e-17 63.5 0.0 1.4e-17 63.5 0.0 2.3 2 1 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 KOG97164.1 - 7.8e-16 57.9 0.0 2.6e-15 56.2 0.0 2.0 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 KOG97164.1 - 8.5e-14 51.1 0.0 2.3e-13 49.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOG97164.1 - 5.5e-07 29.2 1.5 7.1e-07 28.8 0.1 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KOG97164.1 - 9.5e-05 22.5 0.3 0.00051 20.1 0.1 2.3 1 1 1 2 2 2 1 AAA domain T2SE PF00437.15 KOG97164.1 - 0.00091 18.2 0.0 0.0018 17.2 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein Flavi_DEAD PF07652.9 KOG97164.1 - 0.0033 17.1 0.0 0.0077 16.0 0.0 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain ABC_tran PF00005.22 KOG97164.1 - 0.038 14.3 2.9 0.098 12.9 0.1 3.0 2 1 0 2 2 2 0 ABC transporter PRK PF00485.13 KOG97165.1 - 2.6e-64 216.3 0.0 4.2e-64 215.6 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.1 KOG97165.1 - 2e-34 118.6 0.0 3e-34 118.0 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_17 PF13207.1 KOG97165.1 - 3.4e-10 40.7 0.1 1.1e-09 39.1 0.1 1.9 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOG97165.1 - 5.7e-08 33.1 0.0 2.8e-07 30.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 KOG97165.1 - 0.0034 16.4 0.0 0.0058 15.7 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin CPT PF07931.7 KOG97165.1 - 0.0046 16.6 0.0 0.027 14.0 0.0 2.0 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.1 KOG97165.1 - 0.029 14.2 0.0 0.085 12.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_26 PF13500.1 KOG97165.1 - 0.1 12.2 0.0 0.31 10.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain SPX PF03105.14 KOG97166.1 - 7.8e-50 170.1 22.2 7.8e-50 170.1 15.4 1.7 2 0 0 2 2 2 1 SPX domain Na_sulph_symp PF00939.14 KOG97166.1 - 4.2e-23 81.9 46.5 5.5e-23 81.5 32.3 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 KOG97166.1 - 2.2e-12 46.2 45.2 6.5e-10 38.1 16.0 2.3 1 1 1 2 2 2 2 Citrate transporter Sec-ASP3 PF15432.1 KOG97167.1 - 0.067 13.1 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Accessory Sec secretory system ASP3 ZF-HD_dimer PF04770.7 KOG97167.1 - 0.12 12.4 5.5 0.93 9.5 0.4 2.6 2 0 0 2 2 2 0 ZF-HD protein dimerisation region Dus PF01207.12 KOG97168.1 - 7.9e-71 238.4 0.0 1.2e-70 237.7 0.0 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) ACC_central PF08326.7 KOG97169.1 - 4.1e-264 878.0 0.0 5.4e-264 877.6 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.17 KOG97169.1 - 8.1e-179 595.0 0.0 1.1e-178 594.6 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.12 KOG97169.1 - 1.4e-50 171.4 0.0 3.3e-50 170.2 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 KOG97169.1 - 1.1e-25 89.8 0.0 2.4e-25 88.7 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 KOG97169.1 - 1.9e-21 76.0 0.0 1.3e-20 73.3 0.0 2.4 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 KOG97169.1 - 2e-16 59.3 0.4 5.9e-16 57.8 0.3 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 KOG97169.1 - 3.2e-11 43.3 0.0 8.3e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 KOG97169.1 - 9.1e-10 37.7 0.0 3e-08 32.7 0.0 2.8 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 KOG97169.1 - 0.00077 18.9 0.0 0.0026 17.1 0.0 1.9 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 KOG97169.1 - 0.0032 17.3 0.0 0.014 15.2 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp PF02222.17 KOG97169.1 - 0.023 14.0 0.0 0.22 10.8 0.0 2.3 2 0 0 2 2 2 0 ATP-grasp domain Tim17 PF02466.14 KOG97170.1 - 6.5e-29 100.5 3.3 9.3e-29 100.0 2.3 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family HIG_1_N PF04588.8 KOG97171.1 - 0.00015 21.3 2.5 0.00015 21.3 1.8 2.1 1 1 1 2 2 2 1 Hypoxia induced protein conserved region cwf21 PF08312.7 KOG97171.1 - 0.16 11.8 0.5 0.16 11.8 0.3 2.0 2 0 0 2 2 2 0 cwf21 domain MBOAT PF03062.14 KOG97172.1 - 1.4e-89 300.3 36.2 2e-89 299.8 25.1 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 KOG97172.1 - 0.00055 19.9 6.0 0.0016 18.5 4.2 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Tir_receptor_C PF07489.6 KOG97172.1 - 0.01 15.5 9.2 0.021 14.6 6.4 1.4 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus DUF3439 PF11921.3 KOG97172.1 - 0.043 13.5 8.8 0.51 10.0 2.5 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Peptidase_M76 PF09768.4 KOG97173.1 - 7e-75 250.2 0.9 8.3e-75 250.0 0.7 1.0 1 0 0 1 1 1 1 Peptidase M76 family Tox-MPTase2 PF15638.1 KOG97173.1 - 0.19 11.2 0.1 0.3 10.6 0.1 1.2 1 0 0 1 1 1 0 Metallopeptidase toxin 2 Ribosomal_L9_N PF01281.14 KOG97174.1 - 0.00056 19.0 0.0 0.0011 18.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain I_LWEQ PF01608.12 KOG97174.1 - 0.081 12.8 2.4 0.11 12.4 1.7 1.2 1 0 0 1 1 1 0 I/LWEQ domain DUF2461 PF09365.5 KOG97175.1 - 0.022 14.1 0.0 0.048 13.0 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein (DUF2461) Y_phosphatase2 PF03162.8 KOG97175.1 - 0.026 13.9 0.1 0.067 12.5 0.1 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family WD40 PF00400.27 KOG97177.1 - 1.7e-07 30.8 0.1 0.00021 21.0 0.1 4.8 5 0 0 5 5 5 1 WD domain, G-beta repeat Pro_isomerase PF00160.16 KOG97178.1 - 5.6e-14 52.6 0.0 1.1e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Big_1 PF02369.11 KOG97178.1 - 0.082 12.8 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) cobW PF02492.14 KOG97179.1 - 1.4e-42 145.0 0.0 2.1e-42 144.5 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 KOG97179.1 - 6.9e-07 28.8 0.0 1.2e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_18 PF13238.1 KOG97179.1 - 0.0016 18.7 0.3 0.0041 17.4 0.2 1.8 1 1 0 1 1 1 1 AAA domain MobB PF03205.9 KOG97179.1 - 0.0035 17.0 0.2 0.023 14.4 0.0 2.4 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B GTP_EFTU PF00009.22 KOG97179.1 - 0.0098 15.3 0.2 0.16 11.4 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 KOG97179.1 - 0.01 15.3 0.6 0.06 12.8 0.0 2.4 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_16 PF13191.1 KOG97179.1 - 0.012 15.6 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.18 KOG97179.1 - 0.015 15.2 0.0 0.051 13.5 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.7 KOG97179.1 - 0.021 14.5 0.1 0.041 13.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Arch_ATPase PF01637.13 KOG97179.1 - 0.021 14.5 0.0 0.041 13.5 0.0 1.6 1 0 0 1 1 1 0 Archaeal ATPase AAA_10 PF12846.2 KOG97179.1 - 0.054 12.9 0.0 0.097 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_14 PF13173.1 KOG97179.1 - 0.069 13.0 0.0 0.23 11.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KOG97179.1 - 0.099 13.4 1.6 0.61 10.9 1.0 2.5 1 1 0 1 1 1 0 AAA domain Snapin_Pallidin PF14712.1 KOG97179.1 - 0.14 12.4 0.6 1.2 9.5 0.1 2.2 2 0 0 2 2 2 0 Snapin/Pallidin AAA_23 PF13476.1 KOG97179.1 - 0.64 10.3 3.8 0.53 10.5 0.3 2.5 3 1 0 3 3 3 0 AAA domain Glyco_transf_22 PF03901.12 KOG97180.1 - 2.4e-33 115.7 22.1 3.2e-33 115.3 15.3 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Pkinase PF00069.20 KOG97181.1 - 6.5e-63 212.3 0.0 1.9e-62 210.7 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97181.1 - 3e-34 118.2 0.2 1.7e-24 86.3 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 KOG97181.1 - 1e-06 27.9 0.2 4.7e-05 22.4 0.1 3.0 2 1 0 2 2 2 1 Kinase-like APH PF01636.18 KOG97181.1 - 0.092 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Metallophos PF00149.23 KOG97182.1 - 1.3e-41 142.2 1.2 1.9e-41 141.6 0.8 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ubiquitin PF00240.18 KOG97183.1 - 2.1e-07 30.2 0.6 2.6e-07 29.9 0.4 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 KOG97183.1 - 0.00021 20.9 0.3 0.00023 20.7 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 KOG97183.1 - 0.0054 16.9 0.4 0.027 14.7 0.3 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain CC2D2AN-C2 PF15625.1 KOG97183.1 - 0.013 14.9 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 CC2D2A N-terminal C2 domain Chorismate_bind PF00425.13 KOG97184.1 - 1.6e-64 217.7 0.0 2.2e-64 217.2 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.23 KOG97184.1 - 1.2e-32 112.9 0.0 2.2e-32 112.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.8 KOG97184.1 - 1.7e-13 50.7 0.0 4.7e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.8 KOG97184.1 - 3.3e-07 29.9 0.0 7.7e-07 28.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 Glucosamine_iso PF01182.15 KOG97185.1 - 1.3e-47 162.1 0.0 2.8e-47 161.0 0.0 1.5 2 0 0 2 2 2 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF3215 PF11503.3 KOG97186.1 - 9.2e-29 98.9 0.0 9.4e-29 98.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3215) P34-Arc PF04045.9 KOG97187.1 - 8.4e-96 319.9 0.5 1.3e-95 319.2 0.3 1.3 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Ribosom_S12_S23 PF00164.20 KOG97188.1 - 5.3e-44 148.5 1.2 6.4e-44 148.2 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_S19 PF00203.16 KOG97189.1 - 1.2e-24 85.6 0.0 1.8e-24 85.1 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S19 DEAD PF00270.24 KOG97190.1 - 1.5e-40 138.4 0.2 2.9e-40 137.5 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG97190.1 - 3.3e-20 71.7 1.0 1.8e-19 69.3 0.2 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOG97190.1 - 1.1e-07 31.8 0.1 1.1e-07 31.8 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOG97190.1 - 0.00086 19.4 0.3 0.0027 17.8 0.1 1.9 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.4 KOG97190.1 - 0.0055 15.7 0.2 0.014 14.4 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Flavi_DEAD PF07652.9 KOG97190.1 - 0.036 13.8 0.2 0.13 11.9 0.0 2.0 2 0 0 2 2 2 0 Flavivirus DEAD domain Z1 PF10593.4 KOG97190.1 - 0.058 12.5 0.9 0.13 11.4 0.3 1.8 2 0 0 2 2 2 0 Z1 domain SDA1 PF05285.7 KOG97190.1 - 5.1 6.2 17.0 9.8 5.3 11.8 1.4 1 0 0 1 1 1 0 SDA1 NOA36 PF06524.7 KOG97190.1 - 5.6 6.1 9.8 9.2 5.4 6.8 1.2 1 0 0 1 1 1 0 NOA36 protein Cation_efflux PF01545.16 KOG97191.1 - 8.4e-07 28.3 16.0 8.6e-07 28.3 9.5 2.1 2 1 0 2 2 2 1 Cation efflux family UbiA PF01040.13 KOG97193.1 - 7.5e-34 117.0 16.7 9.9e-34 116.7 11.6 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family GHMP_kinases_N PF00288.21 KOG97194.1 - 3.1e-10 39.9 1.2 1e-09 38.3 0.8 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain CbiA PF01656.18 KOG97194.1 - 0.0022 17.4 0.0 0.0081 15.5 0.0 1.8 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain Trm112p PF03966.11 KOG97197.1 - 1e-20 73.8 0.0 1.2e-20 73.5 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein Pkinase PF00069.20 KOG97198.1 - 1.8e-73 246.9 0.1 2.8e-73 246.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97198.1 - 6.8e-33 113.8 0.1 7.9e-32 110.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG97198.1 - 9.3e-08 31.3 0.2 5.4e-05 22.2 0.0 2.5 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.9 KOG97198.1 - 0.073 12.1 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CDC50 PF03381.10 KOG97199.1 - 1.1e-92 310.1 1.0 1.5e-92 309.7 0.7 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Mso1_Sec1_bdg PF14475.1 KOG97200.1 - 1.3e-19 69.2 0.1 2.7e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 Sec1-binding region of Mso1 DUF605 PF04652.11 KOG97200.1 - 1.4 8.2 11.5 1.6 8.0 8.0 1.2 1 0 0 1 1 1 0 Vta1 like Saccharop_dh PF03435.13 KOG97201.1 - 2.4e-127 425.1 0.0 2.8e-127 424.8 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 KOG97201.1 - 3.2e-07 30.5 0.1 5.4e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 KOG97201.1 - 2e-05 24.6 0.4 3.7e-05 23.8 0.3 1.4 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 KOG97201.1 - 0.0023 16.6 0.1 0.0036 16.0 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 KOG97201.1 - 0.0076 15.5 0.1 0.051 12.8 0.1 1.9 2 0 0 2 2 2 1 NmrA-like family DapB_N PF01113.15 KOG97201.1 - 0.081 12.8 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.16 KOG97201.1 - 0.095 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 KOG97201.1 - 0.11 12.7 0.1 0.42 10.9 0.1 1.8 1 1 1 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NTF2 PF02136.15 KOG97202.1 - 6.7e-26 90.9 0.1 1.1e-25 90.2 0.1 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.17 KOG97202.1 - 0.00051 19.6 0.1 0.0011 18.5 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG97202.1 - 0.0019 18.1 0.1 0.082 12.9 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CAF1 PF04857.15 KOG97203.1 - 1.5e-56 191.6 1.9 1.5e-56 191.6 1.3 1.6 2 0 0 2 2 2 1 CAF1 family ribonuclease Spc7_N PF15402.1 KOG97203.1 - 1.4 6.7 7.0 2.3 6.1 4.9 1.2 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 TFIIA PF03153.8 KOG97203.1 - 3.3 7.4 22.2 1.1 9.0 12.4 1.9 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RRM_1 PF00076.17 KOG97204.1 - 0.0013 18.3 0.0 0.22 11.1 0.0 2.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG97204.1 - 0.012 15.4 0.4 0.095 12.5 0.1 2.5 2 1 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHD_3 PF13922.1 KOG97204.1 - 3.9 7.7 0.0 3.9 7.7 0.0 3.1 3 2 0 3 3 3 0 PHD domain of transcriptional enhancer, Asx RP-C_C PF11800.3 KOG97204.1 - 5.4 6.6 20.9 3.3 7.3 5.3 2.2 2 0 0 2 2 2 0 Replication protein C C-terminal region Sir1 PF11603.3 KOG97205.1 - 1.2e-07 31.9 1.0 3.6e-05 23.9 0.0 3.5 3 1 1 4 4 4 2 Regulatory protein Sir1 SRP1_TIP1 PF00660.12 KOG97206.1 - 4.2e-32 110.0 0.1 5.2e-32 109.7 0.1 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family MFS_1 PF07690.11 KOG97207.1 - 2e-34 118.9 15.6 2e-34 118.9 10.8 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily AA_permease_2 PF13520.1 KOG97208.1 - 1.2e-36 126.1 51.0 6e-36 123.8 35.4 1.8 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOG97208.1 - 1.8e-09 36.5 44.6 8.3e-06 24.4 21.1 2.4 2 1 0 2 2 2 2 Amino acid permease AAA_26 PF13500.1 KOG97209.1 - 2.3e-48 164.4 0.0 2.6e-48 164.2 0.0 1.0 1 0 0 1 1 1 1 AAA domain DUF1611 PF07755.6 KOG97209.1 - 0.0097 14.5 0.0 0.095 11.3 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1611) CbiA PF01656.18 KOG97209.1 - 0.015 14.6 0.2 0.83 9.0 0.1 2.1 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Aminotran_3 PF00202.16 KOG97210.1 - 1.1e-84 284.1 0.0 1.7e-84 283.5 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 KOG97210.1 - 0.032 13.3 0.0 0.039 13.0 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Mannosyl_trans3 PF11051.3 KOG97211.1 - 8.6e-63 212.2 0.5 1.2e-62 211.7 0.3 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative FAD_binding_8 PF08022.7 KOG97212.1 - 6.1e-29 99.9 0.0 1.4e-28 98.7 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 KOG97212.1 - 6.6e-28 97.5 0.0 1.1e-27 96.8 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 KOG97212.1 - 6.9e-20 71.3 14.0 6.9e-20 71.3 9.7 2.3 3 0 0 3 3 3 1 Ferric reductase like transmembrane component MARVEL PF01284.18 KOG97213.1 - 7.3e-13 48.5 3.9 1.1e-12 47.9 2.7 1.3 1 0 0 1 1 1 1 Membrane-associating domain CbiQ PF02361.11 KOG97213.1 - 0.097 12.2 11.2 0.04 13.4 5.8 1.8 2 0 0 2 2 2 0 Cobalt transport protein DUF3353 PF11833.3 KOG97213.1 - 0.82 9.0 3.8 0.23 10.9 0.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3353) Zn_clus PF00172.13 KOG97214.1 - 9.2e-06 25.4 17.2 2.4e-05 24.1 11.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_6 PF12697.2 KOG97215.1 - 1.1e-30 107.2 0.0 1.4e-30 106.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOG97215.1 - 2.5e-24 86.1 0.1 3.9e-24 85.4 0.1 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOG97215.1 - 7.4e-12 45.2 0.0 4.5e-11 42.6 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 KOG97215.1 - 0.00068 19.4 0.0 0.0018 18.1 0.0 1.7 1 0 0 1 1 1 1 Putative lysophospholipase FSH1 PF03959.8 KOG97215.1 - 0.025 14.0 0.0 0.55 9.6 0.0 2.4 2 1 0 2 2 2 0 Serine hydrolase (FSH1) Ndr PF03096.9 KOG97215.1 - 0.042 12.3 0.0 0.052 12.0 0.0 1.2 1 0 0 1 1 1 0 Ndr family Glyco_hydro_81 PF03639.8 KOG97216.1 - 6.5e-302 1002.7 29.4 6.5e-302 1002.7 20.4 2.0 2 1 1 3 3 3 1 Glycosyl hydrolase family 81 Bul1_N PF04425.7 KOG97217.1 - 1.1e-99 334.0 0.2 1.8e-99 333.3 0.2 1.3 1 0 0 1 1 1 1 Bul1 N terminus Bul1_C PF04426.7 KOG97217.1 - 3e-70 236.5 5.0 3e-70 236.5 3.5 2.2 2 0 0 2 2 2 1 Bul1 C terminus Glyco_hydro_28 PF00295.12 KOG97218.1 - 1.6e-100 336.2 24.2 1.8e-100 336.0 16.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.1 KOG97218.1 - 0.015 15.0 39.8 0.68 9.6 27.3 3.0 1 1 1 2 2 2 0 Right handed beta helix region Alpha-amylase PF00128.19 KOG97219.1 - 6.6e-106 354.2 0.1 1e-105 353.6 0.1 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.1 KOG97219.1 - 0.0095 14.8 0.5 0.018 13.9 0.0 1.6 2 0 0 2 2 2 1 glucanotransferase domain of human glycogen debranching enzyme Fungal_trans PF04082.13 KOG97220.1 - 1.5e-23 83.0 6.8 2.4e-23 82.3 4.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG97220.1 - 9.8e-08 31.7 13.9 2.1e-07 30.6 9.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3949 PF13133.1 KOG97220.1 - 0.038 14.2 0.1 0.096 12.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3949) Sugar_tr PF00083.19 KOG97221.1 - 1.1e-98 330.8 21.1 1.2e-98 330.6 14.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.1 KOG97221.1 - 5.9e-09 34.8 23.5 7.3e-08 31.2 1.1 3.6 3 1 1 4 4 4 3 MFS/sugar transport protein MFS_1 PF07690.11 KOG97221.1 - 1e-07 31.0 32.1 1.5e-06 27.2 6.4 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.13 KOG97222.1 - 3.4e-17 62.1 5.3 5.2e-17 61.5 3.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG97222.1 - 1.5e-08 34.3 18.9 4.1e-08 32.9 13.1 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_zinc_N PF00107.21 KOG97224.1 - 2.4e-17 62.7 0.5 3.9e-17 62.0 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase LAB_N PF07578.6 KOG97224.1 - 0.052 13.4 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Lipid A Biosynthesis N-terminal domain adh_short PF00106.20 KOG97224.1 - 0.18 11.7 0.4 0.47 10.3 0.2 1.7 2 0 0 2 2 2 0 short chain dehydrogenase ERO1 PF04137.10 KOG97225.1 - 2.3e-118 395.2 2.0 2.3e-118 395.2 1.4 1.8 2 0 0 2 2 2 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) COX14 PF14880.1 KOG97226.1 - 1.2e-24 85.6 1.9 1.4e-24 85.4 1.3 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c assembly DUF533 PF04391.7 KOG97226.1 - 0.1 11.9 0.0 0.1 11.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Ish1 PF10281.4 KOG97228.1 - 2.9e-48 161.5 49.4 1.6e-12 47.2 0.1 7.8 7 0 0 7 7 7 5 Putative stress-responsive nuclear envelope protein SAP PF02037.22 KOG97228.1 - 4.2e-05 22.9 0.0 10 5.7 0.0 6.1 6 2 0 6 6 6 1 SAP domain MscS_porin PF12795.2 KOG97228.1 - 0.002 17.4 0.3 0.002 17.4 0.2 3.0 3 1 1 4 4 4 1 Mechanosensitive ion channel porin domain HeH PF12949.2 KOG97228.1 - 0.0023 17.4 1.1 15 5.2 0.0 4.2 4 0 0 4 4 4 0 HeH/LEM domain DUF4286 PF14114.1 KOG97228.1 - 0.0044 17.2 5.2 12 6.2 0.1 4.5 4 0 0 4 4 4 2 Domain of unknown function (DUF4286) Slx4 PF09494.5 KOG97228.1 - 0.019 14.7 5.3 5.7 6.7 0.0 4.9 5 0 0 5 5 5 0 Slx4 endonuclease Sep15_SelM PF08806.6 KOG97228.1 - 0.064 13.0 0.3 86 2.9 0.0 4.0 3 0 0 3 3 3 0 Sep15/SelM redox domain DegS PF05384.6 KOG97228.1 - 0.067 12.4 5.3 2.4 7.3 0.3 3.6 3 0 0 3 3 3 0 Sensor protein DegS DUF2094 PF09867.4 KOG97228.1 - 0.48 10.3 5.3 0.36 10.7 0.1 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2094) SAM_2 PF07647.12 KOG97228.1 - 1.5 8.6 16.3 5.9 6.8 0.1 6.4 7 0 0 7 7 7 0 SAM domain (Sterile alpha motif) HMG_CoA_synt_C PF08540.5 KOG97230.1 - 7.3e-112 373.4 5.3 9.3e-112 373.1 3.7 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.12 KOG97230.1 - 1.6e-98 327.3 0.8 2.5e-98 326.7 0.6 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal FAD_binding_6 PF00970.19 KOG97231.1 - 2.5e-26 91.6 0.0 6.6e-26 90.3 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 KOG97231.1 - 1.4e-23 83.5 0.0 2.3e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 KOG97231.1 - 0.00049 20.0 0.0 0.0029 17.5 0.0 2.0 1 1 0 2 2 2 1 Ferric reductase NAD binding domain Tubulin_C PF03953.12 KOG97232.1 - 2.7e-49 166.3 0.1 3.9e-49 165.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.20 KOG97232.1 - 2.5e-31 109.1 0.0 3.8e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain MSP PF01716.13 KOG97232.1 - 0.029 13.4 0.1 0.065 12.2 0.0 1.5 2 0 0 2 2 2 0 Manganese-stabilising protein / photosystem II polypeptide Sugar_tr PF00083.19 KOG97233.1 - 7e-47 160.0 13.0 1.6e-46 158.8 9.0 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG97233.1 - 1.6e-24 86.3 5.6 5e-16 58.3 2.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BRI3BP PF14965.1 KOG97233.1 - 0.11 11.8 0.2 0.25 10.6 0.2 1.5 1 0 0 1 1 1 0 Negative regulator of p53/TP53 Gtr1_RagA PF04670.7 KOG97234.1 - 6.5e-95 316.6 1.8 8.3e-95 316.3 1.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 KOG97234.1 - 1.3e-09 37.6 0.3 5.5e-09 35.6 0.0 1.9 2 0 0 2 2 2 1 Ras family Miro PF08477.8 KOG97234.1 - 2.1e-08 34.6 0.1 5.1e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOG97234.1 - 8.4e-08 31.6 0.1 1.8e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOG97234.1 - 3.8e-06 26.8 0.0 9.5e-06 25.5 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOG97234.1 - 0.0033 16.8 0.0 0.0041 16.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.22 KOG97234.1 - 0.0057 16.9 0.1 0.017 15.4 0.0 2.0 2 1 0 2 2 2 1 ABC transporter AAA_29 PF13555.1 KOG97234.1 - 0.013 15.0 0.2 0.026 14.0 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AIG1 PF04548.11 KOG97234.1 - 0.034 13.2 0.6 0.31 10.1 0.1 2.3 1 1 0 2 2 2 0 AIG1 family DUF815 PF05673.8 KOG97234.1 - 0.04 12.8 0.0 0.079 11.8 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF815) AAA_10 PF12846.2 KOG97234.1 - 0.056 12.8 0.2 0.11 11.8 0.1 1.4 1 1 0 1 1 1 0 AAA-like domain Guanylate_kin PF00625.16 KOG97234.1 - 0.081 12.3 1.7 0.71 9.2 0.4 2.7 2 1 0 2 2 2 0 Guanylate kinase Pyr_redox_2 PF07992.9 KOG97235.1 - 1.8e-29 103.0 0.6 8.4e-18 64.9 0.0 4.2 3 1 1 4 4 4 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOG97235.1 - 9.2e-14 51.6 0.0 1.1e-11 44.9 0.1 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOG97235.1 - 3.4e-09 37.0 0.1 0.0014 18.6 0.0 3.4 2 1 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_28 PF02636.12 KOG97235.1 - 0.02 14.3 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase K_oxygenase PF13434.1 KOG97235.1 - 0.038 12.9 0.1 3.7 6.3 0.0 3.0 3 1 1 4 4 4 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 KOG97235.1 - 0.16 11.7 0.4 6.2 6.5 0.1 3.1 2 2 1 3 3 3 0 FAD-NAD(P)-binding Exo_endo_phos PF03372.18 KOG97237.1 - 9.2e-22 78.1 0.0 1.2e-21 77.8 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Nab6_mRNP_bdg PF10567.4 KOG97238.1 - 4.2e-116 387.2 13.3 4.2e-116 387.2 9.2 3.4 3 1 0 3 3 3 1 RNA-recognition motif RRM PF10378.4 KOG97238.1 - 9.7e-23 79.5 4.8 9.7e-23 79.5 3.3 2.5 1 1 1 2 2 2 1 Putative RRM domain RRM_6 PF14259.1 KOG97238.1 - 3.5e-10 39.6 0.3 1.3e-05 25.0 0.0 4.0 5 0 0 5 5 5 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG97238.1 - 9.3e-07 28.6 0.0 0.0016 18.2 0.0 3.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOG97238.1 - 6.5e-06 25.6 0.1 0.0023 17.4 0.0 4.1 4 0 0 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MFS_1 PF07690.11 KOG97239.1 - 7.6e-27 93.9 63.0 6.1e-25 87.6 43.7 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF843 PF05814.6 KOG97239.1 - 0.055 13.2 0.6 0.055 13.2 0.4 3.1 4 0 0 4 4 4 0 Baculovirus protein of unknown function (DUF843) Sugar_tr PF00083.19 KOG97239.1 - 0.14 10.6 41.6 0.0063 15.1 8.9 3.6 2 1 2 4 4 4 0 Sugar (and other) transporter SLAC1 PF03595.12 KOG97239.1 - 2.1 6.8 45.5 0.0082 14.8 18.1 3.0 2 1 0 2 2 2 0 Voltage-dependent anion channel Anp1 PF03452.9 KOG97240.1 - 1.2e-124 414.8 0.0 1.6e-124 414.4 0.0 1.2 1 0 0 1 1 1 1 Anp1 TAF8_C PF10406.4 KOG97241.1 - 6.6e-21 74.1 0.2 6.6e-21 74.1 0.2 2.4 3 0 0 3 3 3 1 Transcription factor TFIID complex subunit 8 C-term DUF3886 PF13025.1 KOG97241.1 - 0.17 11.8 11.5 0.54 10.2 8.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) Spt20 PF12090.3 KOG97242.1 - 1.3 8.3 10.3 1.5 8.1 6.7 1.5 1 1 0 1 1 1 0 Spt20 family PAT1 PF09770.4 KOG97242.1 - 8.9 4.4 26.6 11 4.1 18.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CTK3_C PF12350.3 KOG97243.1 - 2.1e-22 78.9 1.0 5e-22 77.7 0.7 1.6 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus CTK3 PF12243.3 KOG97243.1 - 2.3e-05 24.0 3.5 0.037 13.6 0.1 2.6 3 0 0 3 3 3 2 CTD kinase subunit gamma CTK3 Bul1_N PF04425.7 KOG97244.1 - 4e-165 549.6 4.3 4e-165 549.6 3.0 2.7 2 1 1 3 3 3 1 Bul1 N terminus Bul1_C PF04426.7 KOG97244.1 - 1.7e-114 381.6 15.6 1.7e-114 381.6 10.8 3.3 4 0 0 4 4 4 1 Bul1 C terminus Ubie_methyltran PF01209.13 KOG97245.1 - 2e-104 347.8 0.1 2.2e-104 347.6 0.1 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 KOG97245.1 - 3.4e-12 46.1 0.0 5.6e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOG97245.1 - 9.2e-09 35.6 0.0 2.2e-08 34.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOG97245.1 - 1.2e-07 32.1 0.0 2e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOG97245.1 - 1.5e-06 28.4 0.0 2.7e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOG97245.1 - 3.5e-06 26.8 0.0 7.2e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOG97245.1 - 3.7e-05 24.2 0.0 7.8e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 KOG97245.1 - 0.0051 16.4 0.0 0.21 11.1 0.0 2.3 1 1 1 2 2 2 1 Hypothetical methyltransferase Methyltransf_26 PF13659.1 KOG97245.1 - 0.14 12.1 0.0 1.6 8.7 0.0 2.7 2 1 0 2 2 2 0 Methyltransferase domain Zds_C PF08632.5 KOG97246.1 - 2.9e-33 113.0 0.7 7.2e-33 111.7 0.5 1.7 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF1892 PF08987.5 KOG97247.1 - 3.3e-44 149.5 6.6 3.6e-44 149.4 4.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1892) zf-C3HC PF07967.8 KOG97248.1 - 1.8e-12 47.1 5.4 8.6e-11 41.7 1.9 2.5 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.5 KOG97248.1 - 1.2e-06 28.2 3.3 4.5e-05 23.2 0.5 2.6 2 0 0 2 2 2 2 Rsm1-like Pribosyltran PF00156.22 KOG97249.1 - 4.4e-17 61.9 0.5 9e-17 60.9 0.2 1.6 2 0 0 2 2 2 1 Phosphoribosyl transferase domain SRP19 PF01922.12 KOG97250.1 - 6.1e-28 97.2 0.0 1.6e-27 95.9 0.0 1.7 2 0 0 2 2 2 1 SRP19 protein PXA PF02194.10 KOG97251.1 - 2.6e-36 124.9 2.9 2.6e-36 124.9 2.0 2.7 3 0 0 3 3 3 1 PXA domain Nexin_C PF08628.7 KOG97251.1 - 5.1e-31 107.0 0.1 5.1e-31 107.0 0.1 2.4 3 0 0 3 3 3 1 Sorting nexin C terminal PX PF00787.19 KOG97251.1 - 5.4e-15 55.1 3.6 5.4e-15 55.1 2.5 3.1 3 0 0 3 3 3 1 PX domain Nup188 PF10487.4 KOG97252.1 - 0 1041.2 48.7 0 1041.2 33.8 1.8 2 0 0 2 2 2 1 Nucleoporin subcomplex protein binding to Pom34 WD40 PF00400.27 KOG97253.1 - 7.1e-30 101.7 7.5 9e-07 28.5 0.0 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.6 KOG97253.1 - 0.0034 17.1 0.0 0.37 10.4 0.0 3.1 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.7 KOG97253.1 - 0.11 12.2 0.2 12 5.6 0.0 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat CUE PF02845.11 KOG97254.1 - 1.1e-06 28.0 0.0 1.6e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 CUE domain PMD PF10536.4 KOG97254.1 - 0.02 13.8 0.0 0.032 13.2 0.0 1.3 1 0 0 1 1 1 0 Plant mobile domain DUF1980 PF09323.5 KOG97254.1 - 0.085 12.5 0.0 0.096 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Glyco_transf_20 PF00982.16 KOG97255.1 - 1.4e-171 571.1 1.6 2e-171 570.6 1.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 KOG97255.1 - 5.3e-50 169.5 0.0 1.1e-49 168.4 0.0 1.5 1 0 0 1 1 1 1 Trehalose-phosphatase Glyco_transf_5 PF08323.6 KOG97255.1 - 0.023 14.1 0.1 0.044 13.2 0.1 1.4 1 0 0 1 1 1 0 Starch synthase catalytic domain IL34 PF15036.1 KOG97255.1 - 0.038 13.5 0.0 0.1 12.1 0.0 1.7 1 0 0 1 1 1 0 Interleukin 34 Glycos_transf_1 PF00534.15 KOG97255.1 - 0.055 12.8 0.0 0.18 11.1 0.0 1.9 1 0 0 1 1 1 0 Glycosyl transferases group 1 Fungal_trans_2 PF11951.3 KOG97256.1 - 4.6e-116 387.5 1.7 6.1e-116 387.1 1.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG97256.1 - 8.4e-13 48.0 8.1 2e-12 46.8 5.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2363 PF10155.4 KOG97256.1 - 0.018 14.9 1.3 5 7.0 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2363) SR-25 PF10500.4 KOG97256.1 - 0.067 12.6 9.5 0.12 11.7 6.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIID-18kDa PF02269.11 KOG97257.1 - 7.5e-36 121.8 0.0 1.2e-35 121.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit TAF PF02969.12 KOG97257.1 - 0.0061 16.4 0.0 0.066 13.1 0.0 2.2 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) Histone PF00125.19 KOG97257.1 - 0.032 14.3 0.0 0.087 12.9 0.0 1.7 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 CDC45 PF02724.9 KOG97257.1 - 5.7 4.8 11.2 6 4.7 7.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4611 PF15387.1 KOG97257.1 - 5.7 7.1 11.6 32 4.7 8.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) VPS9 PF02204.13 KOG97258.1 - 8.8e-31 106.0 0.0 1.9e-30 104.9 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CUE PF02845.11 KOG97258.1 - 1.7e-11 43.3 0.0 2.9e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 CUE domain Asn_synthase PF00733.16 KOG97259.1 - 1.6e-47 162.2 0.0 2.5e-47 161.5 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 KOG97259.1 - 3.2e-12 46.2 0.0 5.3e-11 42.3 0.0 2.7 2 1 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.1 KOG97259.1 - 1.1e-09 38.3 0.0 5e-09 36.2 0.0 2.1 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.3 KOG97259.1 - 0.033 13.3 0.0 0.093 11.9 0.0 1.8 1 1 0 1 1 1 0 Aluminium induced protein DUF3124 PF11322.3 KOG97259.1 - 0.085 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3124) DUF3730 PF12530.3 KOG97259.1 - 0.18 11.6 0.0 1.3 8.8 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3730) Rad10 PF03834.9 KOG97260.1 - 6.2e-27 93.1 1.9 9.8e-27 92.4 1.3 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Calreticulin PF00262.13 KOG97260.1 - 0.014 14.0 0.2 0.021 13.4 0.2 1.3 1 0 0 1 1 1 0 Calreticulin family Prefoldin PF02996.12 KOG97261.1 - 4e-29 100.7 2.0 4e-29 100.7 1.4 1.4 1 1 0 1 1 1 1 Prefoldin subunit Peptidase_C50 PF03568.12 KOG97261.1 - 0.7 8.5 5.9 1.3 7.6 4.1 1.4 1 1 0 1 1 1 0 Peptidase family C50 Utp14 PF04615.8 KOG97262.1 - 5.3e-217 722.5 77.7 5.3e-217 722.5 53.8 2.0 1 1 1 2 2 2 1 Utp14 protein Proteasome PF00227.21 KOG97263.1 - 3e-58 196.2 0.0 4.1e-58 195.7 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KOG97263.1 - 4.3e-09 35.5 0.8 7.8e-09 34.6 0.1 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RPM2 PF08579.6 KOG97264.1 - 8.6e-52 174.3 3.7 8.6e-52 174.3 2.5 2.7 2 0 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) PPR_2 PF13041.1 KOG97264.1 - 0.00088 19.2 3.2 5.9 6.9 0.0 5.0 5 0 0 5 5 5 2 PPR repeat family PPR PF01535.15 KOG97264.1 - 0.16 12.0 0.8 26 5.0 0.0 4.1 4 0 0 4 4 4 0 PPR repeat F-box-like PF12937.2 KOG97265.1 - 1.1e-10 41.0 0.1 2.4e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 KOG97265.1 - 2.7e-09 36.4 0.0 7.4e-09 35.0 0.0 1.8 1 0 0 1 1 1 1 F-box domain UIM PF02809.15 KOG97265.1 - 0.00063 19.1 23.5 0.0013 18.0 0.3 4.4 4 0 0 4 4 4 2 Ubiquitin interaction motif PGC7_Stella PF15549.1 KOG97265.1 - 3.6 7.5 7.2 0.89 9.5 2.4 1.8 2 0 0 2 2 2 0 PGC7/Stella/Dppa3 domain FAD_binding_6 PF00970.19 KOG97266.1 - 3.8e-27 94.2 0.0 5.9e-27 93.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 KOG97266.1 - 3.3e-23 82.3 0.0 6.2e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 KOG97266.1 - 3.6e-05 23.7 0.0 0.0017 18.2 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain MrpF_PhaF PF04066.8 KOG97266.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) ALO PF04030.9 KOG97267.1 - 6.9e-103 343.7 0.4 9e-103 343.3 0.3 1.1 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 KOG97267.1 - 3.4e-25 88.1 0.0 5.2e-25 87.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 KOG97267.1 - 0.0054 16.6 0.4 0.017 14.9 0.3 1.8 1 0 0 1 1 1 1 Berberine and berberine like SIS_2 PF13580.1 KOG97267.1 - 0.14 11.8 0.0 0.3 10.7 0.0 1.6 1 0 0 1 1 1 0 SIS domain Tubulin_C PF03953.12 KOG97268.1 - 3e-50 169.4 0.0 4.1e-50 169.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Cys_Met_Meta_PP PF01053.15 KOG97270.1 - 4.8e-23 81.0 0.0 1.3e-22 79.6 0.0 1.7 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme RRM_6 PF14259.1 KOG97270.1 - 0.088 12.8 0.0 15 5.6 0.0 2.6 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) ATP-synt_J PF04911.7 KOG97271.1 - 5.4e-29 99.4 0.7 5.9e-29 99.3 0.5 1.0 1 0 0 1 1 1 1 ATP synthase j chain zf-C2H2 PF00096.21 KOG97272.1 - 2.3e-06 27.6 15.4 0.00036 20.7 2.5 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KOG97272.1 - 1.8e-05 24.8 9.8 5.8e-05 23.1 3.1 2.7 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOG97272.1 - 0.005 17.0 15.7 0.038 14.3 2.7 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger Dus PF01207.12 KOG97273.1 - 9.1e-87 290.7 0.0 1.1e-86 290.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Cupin_5 PF06172.6 KOG97274.1 - 8.9e-39 132.5 0.0 1.1e-38 132.3 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) Sybindin PF04099.7 KOG97275.1 - 9.7e-20 70.7 0.3 1.2e-19 70.3 0.2 1.1 1 0 0 1 1 1 1 Sybindin-like family OstA_C PF04453.9 KOG97275.1 - 0.00057 19.0 0.7 0.0013 17.8 0.3 1.5 1 1 1 2 2 2 1 Organic solvent tolerance protein Sedlin_N PF04628.8 KOG97275.1 - 0.0014 18.4 0.1 0.0015 18.3 0.1 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region HMG-CoA_red PF00368.13 KOG97277.1 - 1.2e-159 530.9 1.0 1.2e-159 530.9 0.7 1.5 2 0 0 2 2 2 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.1 KOG97277.1 - 4.9e-46 156.2 1.1 1.3e-45 154.8 0.8 1.8 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.3 KOG97277.1 - 7.4e-08 31.9 5.9 7.4e-08 31.9 4.1 2.0 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation FKBP_C PF00254.23 KOG97278.1 - 6.1e-28 96.6 0.2 2.3e-27 94.8 0.0 2.1 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase TFIIF_alpha PF05793.7 KOG97278.1 - 0.28 9.4 73.7 0.025 12.9 17.3 2.2 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SET PF00856.23 KOG97278.1 - 1.7 8.9 5.9 3.7 7.8 0.7 2.3 2 0 0 2 2 2 0 SET domain GAGA_bind PF06217.7 KOG97278.1 - 1.9 8.4 22.8 3.9 7.3 1.0 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family RNA_polI_A34 PF08208.6 KOG97278.1 - 6 6.4 54.1 2.2 7.9 22.2 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 SDA1 PF05285.7 KOG97278.1 - 9.5 5.3 62.0 2.1 7.5 14.4 2.2 2 0 0 2 2 2 0 SDA1 PhzC-PhzF PF02567.11 KOG97279.1 - 3.7e-73 246.1 0.0 4.2e-73 245.9 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.6 KOG97279.1 - 0.0037 16.1 0.0 0.049 12.4 0.0 2.0 2 0 0 2 2 2 1 Proline racemase Ribosomal_L6e PF01159.14 KOG97280.1 - 2.1e-39 134.1 2.5 2.9e-39 133.6 1.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e C2 PF00168.25 KOG97281.1 - 7.4e-47 157.1 2.6 3.5e-17 62.0 0.1 5.6 5 0 0 5 5 5 5 C2 domain Noelin-1 PF12308.3 KOG97281.1 - 0.07 12.9 0.1 1.1 9.1 0.1 2.5 1 1 0 1 1 1 0 Neurogenesis glycoprotein O-ag_pol_Wzy PF14296.1 KOG97281.1 - 0.34 9.4 4.7 0.5 8.8 3.3 1.2 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy Dor1 PF04124.7 KOG97282.1 - 1.7e-74 250.3 7.5 3.2e-74 249.3 5.2 1.4 1 0 0 1 1 1 1 Dor1-like family Hid1 PF12722.2 KOG97282.1 - 8.1e-05 20.5 11.3 8.1e-05 20.5 7.8 2.1 2 0 0 2 2 2 2 High-temperature-induced dauer-formation protein TFIIF_alpha PF05793.7 KOG97282.1 - 0.00048 18.6 32.7 0.00048 18.6 22.7 2.3 2 0 0 2 2 2 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF966 PF06136.8 KOG97282.1 - 0.34 10.2 23.6 0.32 10.3 11.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF966) Dak1 PF02733.12 KOG97283.1 - 1.2e-141 470.9 1.9 1.6e-141 470.5 1.3 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 KOG97283.1 - 4.8e-44 150.0 2.1 5.9e-44 149.8 0.5 1.9 2 0 0 2 2 2 1 DAK2 domain SSrecog PF03531.9 KOG97284.1 - 6.2e-70 234.9 4.5 2.5e-41 141.4 0.2 2.7 2 1 1 3 3 3 2 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.7 KOG97284.1 - 2e-29 101.4 0.3 2.4e-26 91.5 0.1 3.1 3 0 0 3 3 3 2 Histone chaperone Rttp106-like DUF3678 PF12435.3 KOG97284.1 - 0.13 11.8 0.6 9.3 5.9 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) IBR PF01485.16 KOG97285.1 - 2e-13 49.9 27.0 1.9e-08 34.0 1.2 4.0 3 1 0 3 3 3 2 IBR domain zf-RING_2 PF13639.1 KOG97285.1 - 0.0037 17.0 8.5 0.0037 17.0 5.9 4.9 3 2 2 5 5 5 2 Ring finger domain COPIIcoated_ERV PF07970.7 KOG97286.1 - 8.8e-31 107.2 0.0 1.2e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter AAA PF00004.24 KOG97288.1 - 6.8e-18 65.1 0.0 5.3e-17 62.2 0.0 2.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) BAH PF01426.13 KOG97288.1 - 3.2e-17 62.3 0.1 7.9e-17 61.1 0.1 1.7 1 0 0 1 1 1 1 BAH domain AAA_22 PF13401.1 KOG97288.1 - 3.1e-06 27.3 0.4 2.5e-05 24.4 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 KOG97288.1 - 4.3e-06 26.8 0.2 0.00021 21.3 0.0 3.1 2 2 1 4 4 4 1 AAA ATPase domain AAA_17 PF13207.1 KOG97288.1 - 0.0015 19.2 2.0 0.016 16.0 0.0 3.5 4 1 0 4 4 4 1 AAA domain NACHT PF05729.7 KOG97288.1 - 0.0026 17.4 0.0 0.038 13.6 0.0 2.6 2 1 0 2 2 2 1 NACHT domain AAA_18 PF13238.1 KOG97288.1 - 0.0075 16.5 0.0 0.0075 16.5 0.0 4.2 4 1 1 5 5 5 1 AAA domain Daxx PF03344.10 KOG97288.1 - 0.11 10.9 38.9 0.0092 14.5 20.6 2.1 2 0 0 2 2 2 0 Daxx Family AAA_19 PF13245.1 KOG97288.1 - 0.19 11.5 0.0 0.52 10.1 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain TFIIF_alpha PF05793.7 KOG97288.1 - 0.24 9.7 41.0 0.0043 15.4 21.5 2.2 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.7 KOG97288.1 - 7.6 4.3 43.1 3.9 5.2 0.7 2.3 2 0 0 2 2 2 0 Nop14-like family Ras PF00071.17 KOG97289.1 - 6.1e-30 103.7 0.1 7.5e-30 103.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG97289.1 - 7.3e-18 65.1 0.1 3.5e-17 63.0 0.0 1.9 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 KOG97289.1 - 2.1e-06 27.0 0.1 2.8e-06 26.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOG97289.1 - 3.6e-05 23.2 0.0 0.00024 20.6 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.16 KOG97289.1 - 6.9e-05 22.1 0.1 8.8e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOG97289.1 - 0.026 14.4 0.1 0.052 13.5 0.1 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase MobB PF03205.9 KOG97289.1 - 0.14 11.8 0.1 0.27 10.9 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Ribosomal_S3Ae PF01015.13 KOG97290.1 - 2.1e-79 265.3 6.7 2.5e-79 265.1 4.6 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.11 KOG97290.1 - 0.065 12.6 0.0 0.15 11.4 0.0 1.6 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Inhibitor_I9 PF05922.11 KOG97290.1 - 0.072 13.6 0.1 0.19 12.2 0.0 1.8 1 1 0 1 1 1 0 Peptidase inhibitor I9 SpoVIF PF14069.1 KOG97290.1 - 0.32 10.7 3.3 5.7 6.7 1.0 2.5 1 1 1 2 2 2 0 Stage VI sporulation protein F THOC7 PF05615.8 KOG97291.1 - 8.9e-26 90.8 1.7 6.4e-24 84.7 1.1 2.7 2 1 0 2 2 2 2 Tho complex subunit 7 PIF1 PF05970.9 KOG97292.1 - 1.7e-84 283.8 0.6 1.5e-63 214.9 0.0 2.4 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 KOG97292.1 - 3.4e-10 39.8 0.0 8e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOG97292.1 - 7.3e-06 26.1 0.0 2e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 KOG97292.1 - 0.00014 21.0 0.1 0.00034 19.8 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Herpes_Helicase PF02689.9 KOG97292.1 - 0.00054 17.8 0.1 0.0071 14.1 0.0 2.1 2 0 0 2 2 2 1 Helicase UvrD_C_2 PF13538.1 KOG97292.1 - 0.007 16.4 0.0 0.035 14.2 0.0 2.2 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 KOG97292.1 - 0.014 15.1 0.1 0.028 14.1 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain PhoH PF02562.11 KOG97292.1 - 0.015 14.5 0.0 0.047 12.9 0.0 1.8 1 0 0 1 1 1 0 PhoH-like protein T2SE PF00437.15 KOG97292.1 - 0.052 12.4 0.0 0.13 11.1 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein HhH-GPD PF00730.20 KOG97293.1 - 4.2e-21 75.2 0.0 9.2e-21 74.1 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein OGG_N PF07934.7 KOG97293.1 - 4.2e-21 75.0 0.2 1.4e-20 73.3 0.1 1.9 2 0 0 2 2 2 1 8-oxoguanine DNA glycosylase, N-terminal domain cNMP_binding PF00027.24 KOG97294.1 - 2.2e-40 136.3 0.2 1.2e-18 66.7 0.0 4.4 5 0 0 5 5 5 3 Cyclic nucleotide-binding domain Patatin PF01734.17 KOG97294.1 - 1.5e-18 67.4 4.0 4.9e-17 62.5 2.1 3.1 2 1 0 2 2 2 1 Patatin-like phospholipase DUF4611 PF15387.1 KOG97294.1 - 0.034 14.3 4.4 0.095 12.8 3.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DUF2457 PF10446.4 KOG97294.1 - 0.74 8.4 12.3 1.7 7.2 8.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sigma70_ner PF04546.8 KOG97294.1 - 2.1 7.9 6.0 1.5 8.3 2.5 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region RNR_inhib PF08591.5 KOG97296.1 - 0.00093 20.0 2.2 0.0012 19.6 1.5 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase inhibitor Mst1_SARAH PF11629.3 KOG97296.1 - 0.067 13.0 0.3 0.14 12.0 0.2 1.5 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 Metallophos PF00149.23 KOG97297.1 - 5.8e-42 143.3 1.0 8.4e-42 142.8 0.7 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SPC25 PF06703.6 KOG97298.1 - 2.4e-43 147.5 2.2 2.7e-43 147.3 1.5 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF843 PF05814.6 KOG97298.1 - 0.016 14.9 0.2 0.016 14.9 0.1 1.8 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) FMN_dh PF01070.13 KOG97299.1 - 4e-120 400.9 0.0 5.1e-120 400.5 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 KOG97299.1 - 3e-22 78.1 0.0 8.4e-22 76.7 0.0 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 KOG97299.1 - 2e-08 33.5 0.0 3.5e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.10 KOG97299.1 - 0.0013 17.9 0.0 0.0017 17.5 0.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 KOG97299.1 - 0.0013 17.6 0.3 0.0099 14.7 0.0 2.3 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.9 KOG97299.1 - 0.12 11.4 0.2 2.7 6.9 0.0 2.2 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 KOG97299.1 - 0.16 11.2 0.8 10 5.3 0.0 2.6 2 1 1 3 3 3 0 Histidine biosynthesis protein SUR7 PF06687.7 KOG97301.1 - 2.3e-36 125.3 11.9 3e-36 125.0 8.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.3 KOG97301.1 - 1.9e-08 34.4 6.4 3.5e-08 33.5 4.4 1.4 1 0 0 1 1 1 1 Ca2+ regulator and membrane fusion protein Fig1 DUF805 PF05656.9 KOG97301.1 - 2.3 8.0 10.9 0.27 11.0 3.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF805) GFO_IDH_MocA PF01408.17 KOG97302.1 - 5e-07 30.2 0.0 7.5e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 KOG97302.1 - 0.072 12.8 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain Suc_Fer-like PF06999.7 KOG97303.1 - 4.2e-33 115.3 0.0 5e-33 115.0 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like CPSF_A PF03178.10 KOG97304.1 - 2.6e-52 177.8 0.4 1.5e-51 175.4 0.3 2.3 1 1 0 1 1 1 1 CPSF A subunit region BBS2_N PF14781.1 KOG97304.1 - 0.0098 15.5 0.5 0.13 11.9 0.1 2.8 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, N-terminal eIF3g PF12353.3 KOG97304.1 - 0.054 13.4 0.6 0.2 11.6 0.1 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G Gsf2 PF11055.3 KOG97305.1 - 1.1e-178 593.5 0.0 1.3e-178 593.2 0.0 1.0 1 0 0 1 1 1 1 Glucose signalling factor 2 Pex24p PF06398.6 KOG97306.1 - 0.0035 16.1 6.8 0.009 14.8 4.7 1.9 1 1 0 1 1 1 1 Integral peroxisomal membrane peroxin Suf PF05843.9 KOG97307.1 - 0.53 9.9 8.6 0.088 12.5 0.2 2.7 2 1 0 3 3 3 0 Suppressor of forked protein (Suf) RNA_pol_I_TF PF04090.7 KOG97308.1 - 6.9e-76 253.9 3.9 7.2e-76 253.9 1.6 1.9 2 0 0 2 2 2 1 RNA polymerase I specific initiation factor Carn_acyltransf PF00755.15 KOG97309.1 - 5.1e-196 652.3 0.1 6e-196 652.0 0.1 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase zf-HIT PF04438.11 KOG97310.1 - 0.0067 16.0 9.8 0.013 15.1 6.8 1.4 1 0 0 1 1 1 1 HIT zinc finger TPT PF03151.11 KOG97311.1 - 3.3e-48 163.2 1.5 3.3e-48 163.2 1.1 2.2 2 0 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 KOG97311.1 - 3.4e-10 39.3 12.1 7e-10 38.3 1.3 2.1 2 0 0 2 2 2 2 UAA transporter family EmrE PF13536.1 KOG97311.1 - 1.1e-05 25.5 3.5 1.1e-05 25.5 2.4 3.2 4 0 0 4 4 4 2 Multidrug resistance efflux transporter EamA PF00892.15 KOG97311.1 - 1.5e-05 25.0 29.1 0.00065 19.7 4.8 3.3 2 2 0 3 3 3 2 EamA-like transporter family DUF914 PF06027.7 KOG97311.1 - 0.0011 17.8 1.5 0.0011 17.8 1.0 2.1 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF914) UPF0546 PF10639.4 KOG97311.1 - 0.029 14.1 9.9 0.95 9.3 0.9 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0546 CGI-121 PF08617.5 KOG97313.1 - 4.7e-28 97.8 0.3 5.2e-28 97.7 0.2 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 LETM1 PF07766.8 KOG97313.1 - 0.072 12.1 0.0 0.076 12.0 0.0 1.1 1 0 0 1 1 1 0 LETM1-like protein A_deaminase PF00962.17 KOG97314.1 - 3.6e-120 400.8 0.2 7.3e-120 399.8 0.1 1.6 2 0 0 2 2 2 1 Adenosine/AMP deaminase MSC PF09402.5 KOG97315.1 - 1.6e-46 158.6 4.3 1.8e-46 158.4 3.0 1.0 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain BACK PF07707.10 KOG97315.1 - 0.0052 16.5 0.5 0.0096 15.7 0.4 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch Mlp PF03304.8 KOG97315.1 - 0.059 13.3 3.4 0.042 13.8 0.7 1.8 2 0 0 2 2 2 0 Mlp lipoprotein family Ndc80_HEC PF03801.8 KOG97315.1 - 0.45 9.9 5.4 1 8.7 0.2 2.9 1 1 0 2 2 2 0 HEC/Ndc80p family FCH PF00611.18 KOG97315.1 - 0.64 10.2 4.2 1.7 8.8 2.9 1.8 1 1 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain Rad52_Rad22 PF04098.10 KOG97316.1 - 1.4e-55 187.2 0.0 2.4e-55 186.4 0.0 1.4 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Ndc1_Nup PF09531.5 KOG97317.1 - 4.5e-136 454.7 8.4 5.1e-136 454.5 5.8 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup HIG_1_N PF04588.8 KOG97318.1 - 1.1e-21 76.2 1.4 1.5e-21 75.8 1.0 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region DUF342 PF03961.8 KOG97318.1 - 0.032 12.6 1.9 0.032 12.6 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF3006 PF11213.3 KOG97318.1 - 0.093 12.4 2.4 0.17 11.6 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3006) DDE_Tnp_IS1 PF03400.8 KOG97318.1 - 0.1 12.7 0.2 0.18 11.9 0.1 1.4 2 0 0 2 2 2 0 IS1 transposase IncA PF04156.9 KOG97318.1 - 0.22 11.1 2.6 0.39 10.2 1.8 1.4 1 0 0 1 1 1 0 IncA protein OmpH PF03938.9 KOG97318.1 - 1.3 8.9 6.0 1.8 8.4 4.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Bap31 PF05529.7 KOG97318.1 - 3.2 7.1 6.7 4.5 6.6 4.6 1.1 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like ubiquitin PF00240.18 KOG97319.1 - 0.00018 20.8 0.1 0.00064 19.0 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin family DUF2407 PF10302.4 KOG97319.1 - 0.012 15.8 0.0 0.038 14.1 0.0 1.9 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 KOG97319.1 - 0.015 15.2 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.3 KOG97319.1 - 0.024 14.2 0.0 0.092 12.4 0.0 2.0 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF1031 PF06275.6 KOG97319.1 - 0.037 14.0 0.4 0.38 10.8 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1031) AhpC-TSA PF00578.16 KOG97320.1 - 1.4e-36 124.9 0.0 8.3e-36 122.4 0.0 1.9 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 KOG97320.1 - 5e-20 71.5 0.0 9.1e-20 70.6 0.0 1.4 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 KOG97320.1 - 9.8e-12 44.3 0.2 2e-11 43.3 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Homeobox PF00046.24 KOG97321.1 - 4.2e-16 58.3 4.3 4.2e-16 58.3 3.0 1.9 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.6 KOG97321.1 - 1.4e-05 24.6 0.1 0.00027 20.5 0.1 2.9 3 0 0 3 3 3 1 Homeobox KN domain DUF468 PF04318.7 KOG97321.1 - 0.12 12.9 1.7 0.68 10.5 0.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF468) Ribosomal_S13 PF00416.17 KOG97322.1 - 1.9e-19 70.0 1.3 2e-19 70.0 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 Ribosomal_L4 PF00573.17 KOG97323.1 - 1.5e-33 115.8 0.0 1.9e-33 115.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Terminase_3 PF04466.8 KOG97323.1 - 0.023 13.7 0.1 0.026 13.6 0.0 1.1 1 0 0 1 1 1 0 Phage terminase large subunit Ribosomal_S17e PF00833.13 KOG97324.1 - 1.3e-56 189.5 0.3 1.6e-56 189.3 0.2 1.0 1 0 0 1 1 1 1 Ribosomal S17 Nse5 PF08691.5 KOG97325.1 - 1.2e-151 505.7 12.0 1.4e-151 505.4 8.3 1.0 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 Pribosyltran PF00156.22 KOG97326.1 - 1.1e-16 60.7 0.0 1.5e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 KOG97326.1 - 0.011 14.9 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase UDG PF03167.14 KOG97327.1 - 7.9e-24 83.8 0.0 1.2e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily HNF-1_N PF04814.8 KOG97328.1 - 0.06 13.4 3.7 1.6 8.7 0.3 2.7 3 0 0 3 3 3 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus OST3_OST6 PF04756.8 KOG97329.1 - 1.3e-31 109.2 11.4 2.1e-31 108.6 7.9 1.3 1 0 0 1 1 1 1 OST3 / OST6 family Bac_Ubq_Cox PF01654.12 KOG97329.1 - 0.0015 17.0 0.3 0.0022 16.5 0.2 1.2 1 0 0 1 1 1 1 Bacterial Cytochrome Ubiquinol Oxidase UAA PF08449.6 KOG97330.1 - 9.2e-08 31.3 4.2 9.2e-08 31.3 2.9 1.5 2 0 0 2 2 2 1 UAA transporter family TPT PF03151.11 KOG97330.1 - 1.1e-07 31.6 21.2 1.8e-05 24.4 4.7 3.1 3 0 0 3 3 3 2 Triose-phosphate Transporter family EamA PF00892.15 KOG97330.1 - 6.4e-07 29.4 32.9 9.7e-05 22.4 3.4 3.6 3 1 0 3 3 3 2 EamA-like transporter family EmrE PF13536.1 KOG97330.1 - 0.00093 19.3 1.8 0.00093 19.3 1.2 3.5 4 1 0 4 4 4 2 Multidrug resistance efflux transporter Metallophos PF00149.23 KOG97332.1 - 3.7e-39 134.2 1.5 3.9e-39 134.1 0.2 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase TAFII28 PF04719.9 KOG97333.1 - 9.1e-28 95.8 5.7 1.8e-27 94.9 0.4 2.9 4 0 0 4 4 4 2 hTAFII28-like protein conserved region Methyltransf_11 PF08241.7 KOG97334.1 - 1.2e-10 41.7 0.0 2.2e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOG97334.1 - 1.9e-06 27.7 0.1 1.2e-05 25.0 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOG97334.1 - 6.9e-05 23.2 0.0 0.00017 21.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOG97334.1 - 0.00027 21.2 0.0 0.00065 20.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOG97334.1 - 0.00032 20.3 0.0 0.0005 19.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOG97334.1 - 0.0094 16.5 0.0 0.02 15.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain UBX PF00789.15 KOG97335.1 - 2.6e-10 40.1 0.1 6.9e-09 35.6 0.0 2.6 2 0 0 2 2 2 1 UBX domain UBA_4 PF14555.1 KOG97335.1 - 3.4e-08 32.8 0.0 8.1e-08 31.6 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain Muted PF14942.1 KOG97335.1 - 0.049 13.5 1.7 0.073 12.9 0.7 1.5 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein EMP24_GP25L PF01105.19 KOG97336.1 - 6.3e-42 143.3 0.0 7.3e-42 143.1 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Rad33 PF08730.5 KOG97337.1 - 1.7e-37 128.5 5.2 1.6e-35 122.1 3.6 2.1 1 1 0 1 1 1 1 Rad33 DUF1947 PF09183.5 KOG97337.1 - 0.0066 16.1 0.3 0.43 10.3 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF1947) Spt5-NGN PF03439.8 KOG97338.1 - 4.7e-21 74.3 0.0 1.2e-20 73.0 0.0 1.8 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.3 KOG97338.1 - 1.6e-19 70.3 13.3 1.6e-19 70.3 9.2 3.5 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.24 KOG97338.1 - 1.7e-16 59.1 8.0 0.00039 20.0 0.3 4.8 4 0 0 4 4 4 4 KOW motif SPT6_acidic PF14632.1 KOG97338.1 - 0.0018 18.3 19.6 0.0018 18.3 13.6 3.1 1 1 2 3 3 3 1 Acidic N-terminal SPT6 Nucleo_P87 PF07267.6 KOG97338.1 - 0.011 14.4 22.1 0.028 13.1 15.3 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Ribosomal_L33 PF00471.15 KOG97339.1 - 0.0011 19.1 2.3 0.0015 18.7 0.1 2.2 2 1 0 2 2 2 1 Ribosomal protein L33 Sterol_MT_C PF08498.5 KOG97340.1 - 1.3e-29 101.9 1.2 1.9e-29 101.3 0.8 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.7 KOG97340.1 - 2.6e-20 72.6 0.0 6.3e-20 71.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOG97340.1 - 1.1e-16 60.7 0.1 2.1e-16 59.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOG97340.1 - 1.3e-14 54.2 0.0 2.4e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOG97340.1 - 4.5e-13 48.9 0.5 6.3e-13 48.4 0.3 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.2 KOG97340.1 - 4e-12 46.6 0.0 9.4e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOG97340.1 - 5.8e-12 45.9 0.1 1.9e-11 44.2 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOG97340.1 - 8.6e-12 45.3 0.0 2.3e-11 43.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOG97340.1 - 5.8e-09 35.3 0.0 9.1e-09 34.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 KOG97340.1 - 1.8e-08 34.3 0.0 4.9e-08 33.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 KOG97340.1 - 1.7e-07 30.9 0.5 4.6e-07 29.5 0.3 1.6 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.13 KOG97340.1 - 0.00061 19.4 0.0 0.0017 17.9 0.0 1.8 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 PrmA PF06325.8 KOG97340.1 - 0.0049 16.0 0.1 0.016 14.3 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 KOG97340.1 - 0.005 16.2 0.0 0.012 15.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 KOG97340.1 - 0.036 13.5 0.0 0.059 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.8 KOG97340.1 - 0.044 13.0 0.1 0.11 11.7 0.0 1.8 2 0 0 2 2 2 0 Histone methylation protein DOT1 N6_N4_Mtase PF01555.13 KOG97340.1 - 0.049 13.1 0.1 4.9 6.5 0.0 2.3 2 0 0 2 2 2 0 DNA methylase Methyltransf_32 PF13679.1 KOG97340.1 - 0.073 12.7 0.2 0.16 11.6 0.0 1.6 2 0 0 2 2 1 0 Methyltransferase domain Haem_oxygenas_2 PF14518.1 KOG97340.1 - 0.088 12.9 0.0 0.23 11.6 0.0 1.8 1 0 0 1 1 1 0 Iron-containing redox enzyme RrnaAD PF00398.15 KOG97340.1 - 0.096 11.6 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase RAG2 PF03089.9 KOG97340.1 - 0.11 11.2 0.0 0.29 9.8 0.0 1.7 2 0 0 2 2 2 0 Recombination activating protein 2 PAP1 PF08601.5 KOG97341.1 - 7e-68 229.8 44.5 7e-68 229.8 30.8 4.5 1 1 2 3 3 3 1 Transcription factor PAP1 bZIP_1 PF00170.16 KOG97341.1 - 3.7e-08 33.1 4.1 1.1e-07 31.6 2.9 1.8 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 KOG97341.1 - 0.0036 17.0 10.8 0.013 15.2 7.5 2.0 1 1 0 1 1 1 1 Basic region leucine zipper Met_10 PF02475.11 KOG97343.1 - 7.2e-09 35.5 0.0 1.3e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.10 KOG97343.1 - 0.0024 17.2 0.0 0.0042 16.4 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.9 KOG97343.1 - 0.0045 16.3 0.0 0.0083 15.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 KOG97343.1 - 0.064 13.2 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 KOG97343.1 - 0.1 12.1 0.0 1.1 8.8 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Glyoxalase PF00903.20 KOG97344.1 - 2.1e-38 131.1 0.0 6.7e-22 77.8 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 KOG97344.1 - 2.7e-31 108.3 0.0 2.5e-15 56.9 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_4 PF13669.1 KOG97344.1 - 5.8e-16 58.4 0.0 2.7e-09 37.0 0.0 3.2 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CppA_N PF14506.1 KOG97344.1 - 4.1e-05 23.2 0.2 0.071 12.7 0.0 2.4 2 0 0 2 2 2 2 CppA N-terminal Glyoxalase_3 PF13468.1 KOG97344.1 - 4.5e-05 23.4 0.0 0.054 13.4 0.0 3.8 3 1 0 3 3 3 1 Glyoxalase-like domain VPS9 PF02204.13 KOG97345.1 - 9.6e-13 48.0 3.4 1.3e-12 47.6 0.7 2.4 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.1 KOG97345.1 - 0.0017 18.5 0.0 8.2 6.8 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ras PF00071.17 KOG97346.1 - 8.2e-47 158.5 0.4 1e-46 158.3 0.2 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG97346.1 - 8.1e-11 42.4 0.1 1.8e-10 41.3 0.0 1.6 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 KOG97346.1 - 1.2e-09 37.6 0.0 1.4e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KOG97346.1 - 9.3e-06 25.1 0.0 1.2e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KOG97346.1 - 0.0015 17.7 0.1 0.0018 17.4 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Pkinase PF00069.20 KOG97347.1 - 1.1e-73 247.5 0.0 1.8e-73 246.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97347.1 - 4.4e-40 137.3 0.0 7.3e-40 136.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.13 KOG97347.1 - 1.7e-37 127.1 0.1 3.8e-20 71.6 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.1 KOG97347.1 - 4.5e-08 32.4 0.0 1.6e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Kinase-like SH3_3 PF08239.6 KOG97347.1 - 0.0011 19.1 0.0 0.0023 18.0 0.0 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Kdo PF06293.9 KOG97347.1 - 0.006 15.6 0.0 0.013 14.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2076 PF09849.4 KOG97348.1 - 2.3e-07 31.1 8.8 2.7e-07 30.8 6.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.8 KOG97348.1 - 0.00012 21.9 5.0 0.00018 21.3 3.5 1.3 1 0 0 1 1 1 1 CHCH domain DUF2453 PF10507.4 KOG97348.1 - 0.19 11.5 1.2 0.32 10.7 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2453) HD-ZIP_N PF04618.7 KOG97348.1 - 0.49 10.9 4.7 7.7 7.0 0.0 2.1 2 0 0 2 2 2 0 HD-ZIP protein N terminus TFIIA PF03153.8 KOG97348.1 - 5.1 6.8 7.8 6.1 6.6 5.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SAP PF02037.22 KOG97349.1 - 2.5e-10 39.5 0.4 4.1e-10 38.9 0.3 1.3 1 0 0 1 1 1 1 SAP domain PX PF00787.19 KOG97350.1 - 8.2e-22 77.1 1.3 2.1e-21 75.8 0.1 2.1 2 0 0 2 2 2 1 PX domain TAF4 PF05236.9 KOG97351.1 - 9.1e-71 238.2 3.9 9.1e-71 238.2 2.7 1.6 2 0 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family TFIID_30kDa PF03540.8 KOG97351.1 - 0.01 15.6 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit Histone PF00125.19 KOG97351.1 - 0.046 13.8 0.1 0.092 12.8 0.0 1.5 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 PLA2_B PF01735.13 KOG97352.1 - 2.3e-224 745.1 3.6 3.6e-224 744.4 2.5 1.3 1 0 0 1 1 1 1 Lysophospholipase catalytic domain PLA2_B PF01735.13 KOG97353.1 - 3.9e-228 757.5 3.2 4.7e-228 757.2 2.2 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain ARD PF03079.9 KOG97354.1 - 3e-50 170.2 0.2 3.5e-50 170.0 0.1 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.6 KOG97354.1 - 2.4e-11 42.9 0.0 4e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 KOG97354.1 - 1.7e-08 34.2 0.0 2.8e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.17 KOG97354.1 - 0.0014 18.1 0.0 0.0029 17.0 0.0 1.5 2 0 0 2 2 2 1 Cupin Cupin_8 PF13621.1 KOG97354.1 - 0.0051 16.3 0.0 0.0092 15.5 0.0 1.5 1 1 1 2 2 2 1 Cupin-like domain Cupin_3 PF05899.7 KOG97354.1 - 0.061 12.7 0.0 0.21 11.0 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF861) PQ-loop PF04193.9 KOG97355.1 - 1.8e-13 49.8 7.9 1.1e-10 40.9 1.8 3.0 2 0 0 2 2 2 2 PQ loop repeat CLU PF13236.1 KOG97356.1 - 9.2e-76 254.1 0.5 2e-75 253.0 0.4 1.6 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.2 KOG97356.1 - 2.9e-33 115.2 0.7 8.7e-21 74.5 0.0 3.7 4 0 0 4 4 4 2 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.1 KOG97356.1 - 2.2e-18 66.1 0.3 3.1e-17 62.4 0.0 2.8 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.1 KOG97356.1 - 8.3e-07 28.8 2.1 0.00039 20.2 0.2 3.4 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOG97356.1 - 0.0024 17.3 2.3 2.9 7.6 0.4 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOG97356.1 - 0.087 12.7 0.2 1.5 8.8 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOG97356.1 - 0.14 11.7 3.4 2.1 8.0 0.1 3.0 3 0 0 3 3 3 0 TPR repeat TPR_2 PF07719.12 KOG97356.1 - 1.4 9.0 3.7 4.6 7.4 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat CTP_transf_1 PF01148.15 KOG97357.1 - 4.4e-07 29.8 1.7 4.4e-07 29.8 1.2 4.4 3 1 0 3 3 3 2 Cytidylyltransferase family SEO_N PF14576.1 KOG97357.1 - 0.0018 17.6 0.7 0.0031 16.8 0.5 1.3 1 0 0 1 1 1 1 Sieve element occlusion N-terminus BUD22 PF09073.5 KOG97358.1 - 4.9e-95 319.1 48.8 6.1e-95 318.8 33.8 1.1 1 0 0 1 1 1 1 BUD22 Ribosomal_S17e PF00833.13 KOG97358.1 - 0.015 15.0 1.3 0.015 15.0 0.9 3.1 3 1 1 4 4 4 0 Ribosomal S17 p450 PF00067.17 KOG97359.1 - 4.4e-54 183.7 0.1 5.4e-54 183.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 KilA-N PF04383.8 KOG97360.1 - 4.3e-05 23.0 0.1 0.00049 19.7 0.1 2.5 1 1 0 1 1 1 1 KilA-N domain ACP_syn_III_C PF08541.5 KOG97360.1 - 0.086 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal SNARE PF05739.14 KOG97361.1 - 2.9e-05 23.6 0.2 2.9e-05 23.6 0.2 3.3 3 0 0 3 3 3 1 SNARE domain TPR_11 PF13414.1 KOG97362.1 - 1.1e-14 53.8 5.2 1.1e-06 28.2 0.8 4.4 2 2 2 4 4 4 4 TPR repeat TPR_2 PF07719.12 KOG97362.1 - 8.7e-11 40.8 0.4 0.13 12.2 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOG97362.1 - 9.9e-11 40.9 7.1 0.048 13.8 0.2 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOG97362.1 - 7.1e-08 31.7 4.8 0.38 10.4 0.0 5.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOG97362.1 - 5.9e-07 29.7 0.5 0.034 14.4 0.0 3.7 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOG97362.1 - 1.3e-06 28.5 0.0 0.5 11.1 0.0 4.7 2 2 4 6 6 6 2 Tetratricopeptide repeat TPR_20 PF14561.1 KOG97362.1 - 1.4e-05 25.1 0.3 0.54 10.3 0.1 3.9 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOG97362.1 - 3.1e-05 24.5 0.0 1.8 9.3 0.0 3.8 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOG97362.1 - 0.00041 20.2 2.1 0.0087 15.9 0.3 3.2 2 2 1 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 KOG97362.1 - 0.00071 19.6 1.2 0.023 14.8 0.1 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 KOG97362.1 - 0.0011 18.6 12.6 0.088 12.6 0.1 5.3 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOG97362.1 - 0.0035 17.6 0.0 16 6.1 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_15 PF13429.1 KOG97362.1 - 0.033 13.2 0.8 0.19 10.7 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Fungal_trans PF04082.13 KOG97363.1 - 6e-23 81.0 11.8 1.9e-22 79.3 8.2 1.9 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG97363.1 - 2.8e-08 33.5 16.0 2.8e-08 33.5 11.1 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amino_oxidase PF01593.19 KOG97364.1 - 1.7e-79 267.9 0.0 2e-79 267.7 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 KOG97364.1 - 4.9e-13 48.8 0.2 9.8e-13 47.9 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 KOG97364.1 - 1.6e-09 38.1 0.0 1.1e-05 25.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOG97364.1 - 2.1e-07 30.1 0.0 0.00012 21.1 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOG97364.1 - 1.4e-05 24.1 0.6 2e-05 23.6 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.14 KOG97364.1 - 7.6e-05 21.9 0.2 0.00011 21.3 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 KOG97364.1 - 0.00056 18.5 0.2 0.017 13.6 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.22 KOG97364.1 - 0.0012 19.2 2.1 0.021 15.1 0.2 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 KOG97364.1 - 0.0012 18.7 0.0 0.0028 17.5 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOG97364.1 - 0.003 16.5 0.1 0.84 8.4 0.1 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Thi4 PF01946.12 KOG97364.1 - 0.0066 15.5 0.1 0.012 14.6 0.1 1.3 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.17 KOG97364.1 - 0.015 14.1 1.3 0.017 14.0 0.3 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Shikimate_DH PF01488.15 KOG97364.1 - 0.016 15.3 0.3 0.13 12.3 0.1 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.1 KOG97364.1 - 0.027 14.2 0.3 4.9 6.9 0.0 2.6 3 0 0 3 3 3 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.16 KOG97364.1 - 0.088 12.3 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Tocopherol_cycl PF14249.1 KOG97364.1 - 0.089 11.4 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 Tocopherol cyclase tRNA_edit PF04073.10 KOG97364.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Aminoacyl-tRNA editing domain Copper-fist PF00649.13 KOG97365.1 - 8.6e-21 72.8 4.9 8.6e-21 72.8 3.4 2.0 2 0 0 2 2 2 1 Copper fist DNA binding domain DUF971 PF06155.7 KOG97365.1 - 0.055 13.8 0.6 4.3 7.8 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF971) Mei5 PF10376.4 KOG97365.1 - 0.42 10.0 4.1 0.82 9.1 0.2 2.3 2 0 0 2 2 2 0 Double-strand recombination repair protein UQ_con PF00179.21 KOG97366.1 - 2.4e-49 166.3 0.0 2.8e-49 166.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 KOG97366.1 - 0.088 12.7 2.5 0.22 11.4 1.8 2.0 1 1 0 1 1 1 0 RWD domain Prok-E2_B PF14461.1 KOG97366.1 - 0.14 11.9 0.2 0.3 10.8 0.1 1.7 2 1 0 2 2 2 0 Prokaryotic E2 family B TrmE_N PF10396.4 KOG97367.1 - 8e-32 109.5 0.0 2.8e-31 107.8 0.0 2.0 2 0 0 2 2 2 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.18 KOG97367.1 - 7.3e-24 83.9 0.3 1.7e-23 82.7 0.1 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTPase_Cys_C PF12631.2 KOG97367.1 - 9e-17 61.2 0.0 2.8e-16 59.6 0.0 1.9 1 0 0 1 1 1 1 Catalytic cysteine-containing C-terminus of GTPase, MnmE FeoB_N PF02421.13 KOG97367.1 - 2.2e-15 56.2 0.2 4.3e-15 55.3 0.1 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.17 KOG97367.1 - 3.2e-07 29.8 0.0 6.3e-07 28.9 0.0 1.5 1 1 0 1 1 1 1 Ras family GTP_EFTU PF00009.22 KOG97367.1 - 1e-06 28.3 0.1 1.3e-05 24.7 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 KOG97367.1 - 8.8e-06 26.2 0.1 6.1e-05 23.4 0.0 2.4 1 1 1 2 2 2 1 Miro-like protein PduV-EutP PF10662.4 KOG97367.1 - 0.00012 21.5 0.0 0.017 14.5 0.0 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.18 KOG97367.1 - 0.00049 19.9 0.5 0.0038 17.0 0.1 2.3 2 0 0 2 2 2 1 Dynamin family Arf PF00025.16 KOG97367.1 - 0.00072 18.8 0.1 0.0055 15.9 0.1 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.11 KOG97367.1 - 0.0016 17.6 0.0 0.0039 16.3 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 cobW PF02492.14 KOG97367.1 - 0.011 15.1 0.8 0.099 12.0 0.1 2.2 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AIG1 PF04548.11 KOG97367.1 - 0.03 13.4 3.4 0.058 12.4 0.2 2.7 2 1 1 3 3 3 0 AIG1 family AAA_28 PF13521.1 KOG97367.1 - 0.071 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Ribonuclease_3 PF00636.21 KOG97368.1 - 3.9e-12 46.6 0.1 1e-11 45.2 0.0 1.8 2 0 0 2 2 2 1 Ribonuclease III domain dsrm PF00035.20 KOG97368.1 - 1.3e-08 35.3 0.0 2.6e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonucleas_3_3 PF14622.1 KOG97368.1 - 0.041 13.8 0.1 0.16 11.9 0.0 1.9 1 1 0 1 1 1 0 Ribonuclease-III-like Cucumo_coat PF00760.13 KOG97369.1 - 0.053 12.4 0.4 0.11 11.4 0.3 1.4 1 0 0 1 1 1 0 Cucumovirus coat protein Pex2_Pex12 PF04757.9 KOG97370.1 - 1.4e-43 148.9 8.7 1.7e-43 148.6 6.0 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.1 KOG97370.1 - 3.6e-05 23.6 5.5 6.4e-05 22.8 3.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOG97370.1 - 0.00015 21.3 3.5 0.00027 20.5 2.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KOG97370.1 - 0.0062 16.3 7.4 0.012 15.4 5.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.1 KOG97370.1 - 0.088 12.6 4.7 0.17 11.7 3.3 1.4 1 0 0 1 1 1 0 Ring finger domain Rad50_zn_hook PF04423.9 KOG97370.1 - 3.5 7.1 5.4 2.6 7.5 0.2 3.2 4 0 0 4 4 4 0 Rad50 zinc hook motif DUF89 PF01937.14 KOG97371.1 - 4.5e-114 380.9 2.6 5.1e-114 380.7 1.8 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 TAP42 PF04177.7 KOG97372.1 - 1.9e-94 316.4 17.2 2.2e-94 316.2 11.9 1.0 1 0 0 1 1 1 1 TAP42-like family Striatin PF08232.7 KOG97373.1 - 1.5e-27 96.5 4.3 3.2e-24 85.7 0.9 2.5 1 1 1 2 2 2 2 Striatin family Mto2_bdg PF12808.2 KOG97373.1 - 0.00051 20.1 1.8 0.00096 19.2 1.2 1.5 1 0 0 1 1 1 1 Micro-tubular organiser Mto1 C-term Mto2-binding region Herpes_BLRF2 PF05812.7 KOG97373.1 - 0.0093 15.7 0.8 0.021 14.6 0.6 1.5 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein NeuB PF03102.9 KOG97373.1 - 0.02 14.0 0.3 0.03 13.4 0.2 1.2 1 0 0 1 1 1 0 NeuB family RSF PF14876.1 KOG97374.1 - 4.3e-175 581.8 13.0 4.8e-175 581.7 9.0 1.0 1 0 0 1 1 1 1 Respiratory growth transcriptional regulator ORC5_C PF14630.1 KOG97374.1 - 0.0016 17.9 1.3 0.0025 17.3 0.9 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus DUF3812 PF12757.2 KOG97375.1 - 2.5e-33 114.7 0.8 2.5e-33 114.7 0.6 5.0 5 1 0 5 5 5 2 Protein of unknown function (DUF3812) FCH PF00611.18 KOG97376.1 - 3.9e-19 68.6 6.1 5.8e-19 68.0 0.0 3.8 4 0 0 4 4 4 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.23 KOG97376.1 - 0.00076 18.8 0.0 0.002 17.4 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 KOG97376.1 - 0.0049 16.3 0.0 0.0081 15.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 KOG97376.1 - 0.006 16.1 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Actin PF00022.14 KOG97377.1 - 7.9e-21 73.9 0.0 5.8e-20 71.0 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 KOG97377.1 - 0.042 12.4 0.0 30 3.0 0.0 3.0 3 0 0 3 3 3 0 MreB/Mbl protein DUF4137 PF13593.1 KOG97378.1 - 1.2e-115 385.9 14.4 1.4e-115 385.7 10.0 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Peptidase_S24 PF00717.18 KOG97379.1 - 5.6e-08 32.3 0.0 1.9e-07 30.6 0.0 1.9 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.4 KOG97379.1 - 0.00072 19.0 0.0 0.0028 17.1 0.0 1.8 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 Rhodanese PF00581.15 KOG97380.1 - 4.4e-09 36.6 0.1 1.4e-08 35.0 0.0 1.9 1 1 0 1 1 1 1 Rhodanese-like domain zf-C2H2 PF00096.21 KOG97381.1 - 4.6e-12 45.5 18.1 3.4e-06 27.0 1.6 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG97381.1 - 1.7e-09 37.3 16.8 0.00026 21.0 1.6 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KOG97381.1 - 5.3e-06 26.4 3.5 5.3e-06 26.4 2.4 3.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 KOG97381.1 - 8.8e-06 25.7 15.2 0.0036 17.3 3.4 2.9 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KOG97381.1 - 9.8e-05 22.4 12.0 0.041 14.0 1.7 2.9 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 KOG97381.1 - 0.0038 17.0 8.8 0.014 15.2 1.4 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger GAGA PF09237.6 KOG97381.1 - 0.0093 15.5 2.7 1.1 8.9 0.3 2.6 1 1 1 2 2 2 2 GAGA factor zf-Di19 PF05605.7 KOG97381.1 - 0.094 12.8 8.6 0.22 11.6 6.0 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF629 PF04780.7 KOG97381.1 - 1.3 7.4 11.7 0.92 7.9 1.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF629) HMA PF00403.21 KOG97382.1 - 1.8e-10 40.7 0.0 5.2e-10 39.3 0.0 1.8 2 0 0 2 2 2 1 Heavy-metal-associated domain Sod_Cu PF00080.15 KOG97382.1 - 6.2e-09 36.1 0.0 1.4e-08 35.0 0.0 1.6 1 1 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) PC4 PF02229.11 KOG97383.1 - 1.4e-20 72.2 0.1 2.5e-20 71.4 0.1 1.4 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) Mitofilin PF09731.4 KOG97383.1 - 0.57 8.7 30.2 0.64 8.6 21.0 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein SOBP PF15279.1 KOG97383.1 - 6.5 7.0 13.6 9.1 6.5 9.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Bap31 PF05529.7 KOG97384.1 - 2.5e-35 121.6 4.7 3.1e-35 121.3 3.2 1.1 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like DUF4181 PF13789.1 KOG97384.1 - 0.032 14.1 3.7 1.3 8.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4181) DUF3112 PF11309.3 KOG97384.1 - 0.13 12.0 3.3 0.6 9.8 2.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3112) DUF2910 PF11139.3 KOG97384.1 - 0.23 10.5 3.0 0.35 9.9 1.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2910) NdhL PF10716.4 KOG97384.1 - 0.35 10.6 6.1 0.12 12.1 1.9 1.8 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit DUF2500 PF10694.4 KOG97384.1 - 1.4 8.9 4.6 1.2 9.1 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2500) DUF1434 PF07254.7 KOG97384.1 - 1.9 8.3 6.2 1.1 9.0 2.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1434) PepSY_TM_2 PF13703.1 KOG97384.1 - 4.5 7.5 6.5 19 5.5 0.1 2.9 2 1 1 3 3 3 0 PepSY-associated TM helix Aldo_ket_red PF00248.16 KOG97385.1 - 7e-50 169.4 0.0 8.6e-50 169.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family SRF-TF PF00319.13 KOG97386.1 - 1.2e-23 82.1 0.2 2e-23 81.3 0.2 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Mucin PF01456.12 KOG97386.1 - 0.0017 18.1 7.8 0.0025 17.5 5.4 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein CDC45 PF02724.9 KOG97386.1 - 0.02 12.9 0.0 0.023 12.7 0.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Pox_RNA_Pol_19 PF05320.7 KOG97386.1 - 0.032 13.9 0.1 0.041 13.6 0.1 1.1 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DUF4611 PF15387.1 KOG97386.1 - 0.038 14.1 1.5 0.075 13.1 1.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Sporozoite_P67 PF05642.6 KOG97386.1 - 0.33 8.7 5.8 0.39 8.5 4.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FAM176 PF14851.1 KOG97386.1 - 0.62 9.7 2.2 0.9 9.2 1.6 1.3 1 0 0 1 1 1 0 FAM176 family Golgin_A5 PF09787.4 KOG97386.1 - 0.62 8.5 4.3 0.79 8.1 2.9 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 SSP160 PF06933.6 KOG97386.1 - 3.5 5.4 6.8 4.4 5.1 4.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 SRF-TF PF00319.13 KOG97387.1 - 3.2e-25 87.0 0.3 4.5e-25 86.6 0.2 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Sporozoite_P67 PF05642.6 KOG97387.1 - 0.38 8.5 12.9 0.012 13.5 4.5 1.4 1 1 0 1 1 1 0 Sporozoite P67 surface antigen Nucleoplasmin PF03066.10 KOG97387.1 - 2.2 7.7 15.1 0.28 10.7 7.3 1.9 2 0 0 2 2 2 0 Nucleoplasmin SDA1 PF05285.7 KOG97387.1 - 3.5 6.8 19.2 6.4 5.9 13.3 1.4 1 0 0 1 1 1 0 SDA1 FAM176 PF14851.1 KOG97387.1 - 3.5 7.2 15.0 0.1 12.2 0.9 2.4 2 0 0 2 2 2 0 FAM176 family CENP-B_dimeris PF09026.5 KOG97387.1 - 4.5 7.5 15.9 10 6.4 11.0 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PWWP PF00855.12 KOG97388.1 - 2.4e-18 66.0 0.6 2.4e-18 66.0 0.4 2.8 2 2 1 3 3 3 1 PWWP domain TFIIF_alpha PF05793.7 KOG97388.1 - 0.26 9.6 33.1 0.37 9.0 18.1 2.3 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Ebola_NP PF05505.7 KOG97388.1 - 2.1 6.3 13.2 2.9 5.8 9.1 1.2 1 0 0 1 1 1 0 Ebola nucleoprotein Nucleoporin2 PF04096.9 KOG97389.1 - 2e-47 160.5 0.1 6.3e-47 158.9 0.0 2.0 2 0 0 2 2 2 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.1 KOG97389.1 - 8.7e-41 138.7 348.8 9.8e-13 48.3 26.8 10.8 3 2 7 10 10 10 8 Nucleoporin FG repeat region Swi3 PF07962.7 KOG97390.1 - 1.2e-28 98.5 0.1 1.2e-28 98.5 0.1 1.8 2 1 0 2 2 2 1 Replication Fork Protection Component Swi3 BOP1NT PF08145.7 KOG97391.1 - 1.2e-102 343.1 8.0 2.3e-102 342.2 5.5 1.5 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.27 KOG97391.1 - 7.3e-29 98.5 8.3 5e-11 42.0 0.2 7.6 7 1 0 7 7 7 4 WD domain, G-beta repeat Colicin_D PF11429.3 KOG97391.1 - 0.046 13.8 0.1 0.11 12.6 0.1 1.6 1 0 0 1 1 1 0 Colicin D eIF-3c_N PF05470.7 KOG97391.1 - 0.047 11.7 2.6 94 0.8 7.3 2.1 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUP PF00674.13 KOG97392.1 - 6.1e-29 100.1 1.9 6.3e-29 100.1 0.4 1.6 1 1 1 2 2 2 1 DUP family DUF2207 PF09972.4 KOG97392.1 - 0.012 14.1 0.7 0.015 13.9 0.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SUR7 PF06687.7 KOG97392.1 - 0.051 13.1 3.6 0.073 12.6 2.5 1.2 1 0 0 1 1 1 0 SUR7/PalI family Epimerase PF01370.16 KOG97393.1 - 1.6e-16 60.4 0.0 1.2e-15 57.6 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 KOG97393.1 - 3e-14 53.4 0.1 5e-14 52.7 0.0 1.5 1 1 1 2 2 2 1 NADH(P)-binding 3Beta_HSD PF01073.14 KOG97393.1 - 5.1e-11 41.7 0.0 9.8e-11 40.8 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 KOG97393.1 - 2.2e-06 27.1 0.0 3.6e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 KOG97393.1 - 5.2e-06 25.5 0.0 3.7e-05 22.7 0.0 2.0 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.20 KOG97393.1 - 5.2e-05 23.2 0.1 8.9e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.7 KOG97393.1 - 0.0011 18.0 0.0 0.0041 16.0 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein TrkA_N PF02254.13 KOG97393.1 - 0.0056 16.6 0.1 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain DapB_N PF01113.15 KOG97393.1 - 0.006 16.4 0.1 0.016 15.1 0.0 1.8 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus UDPG_MGDP_dh_N PF03721.9 KOG97393.1 - 0.019 14.3 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain KR PF08659.5 KOG97393.1 - 0.06 13.0 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 KR domain GP41 PF00517.12 KOG97395.1 - 0.062 12.8 0.1 0.16 11.4 0.1 1.7 1 0 0 1 1 1 0 Retroviral envelope protein Bul1_C PF04426.7 KOG97395.1 - 0.12 11.5 5.5 0.039 13.1 1.6 1.8 2 0 0 2 2 2 0 Bul1 C terminus PHD PF00628.24 KOG97395.1 - 0.43 10.3 2.6 1.1 9.0 1.8 1.7 1 0 0 1 1 1 0 PHD-finger V_ATPase_I PF01496.14 KOG97396.1 - 0 1011.0 5.1 0 1010.8 3.5 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family KdpD PF02702.12 KOG97396.1 - 0.0033 16.5 0.3 0.0065 15.6 0.2 1.4 1 0 0 1 1 1 1 Osmosensitive K+ channel His kinase sensor domain stn_TNFRSF12A PF12191.3 KOG97396.1 - 0.041 13.9 0.5 2.7 8.0 0.0 2.4 2 0 0 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF4618 PF15397.1 KOG97396.1 - 0.094 12.0 7.6 0.42 9.9 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) SPX PF03105.14 KOG97396.1 - 0.27 10.9 0.7 0.53 10.0 0.0 1.7 2 0 0 2 2 2 0 SPX domain GCN5L1 PF06320.8 KOG97396.1 - 0.34 10.7 4.0 7.7 6.3 0.1 2.8 3 0 0 3 3 3 0 GCN5-like protein 1 (GCN5L1) IncA PF04156.9 KOG97396.1 - 0.45 10.0 2.2 12 5.4 0.1 2.6 2 0 0 2 2 2 0 IncA protein Syntaxin_2 PF14523.1 KOG97396.1 - 1.5 8.9 4.9 8.5 6.4 0.3 2.6 2 0 0 2 2 2 0 Syntaxin-like protein BLOC1_2 PF10046.4 KOG97396.1 - 2.3 8.4 7.9 20 5.4 0.7 2.8 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.7 KOG97396.1 - 2.6 7.8 9.3 12 5.6 2.6 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus RabGAP-TBC PF00566.13 KOG97397.1 - 2.6e-36 125.1 1.0 4e-36 124.4 0.7 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Mito_carr PF00153.22 KOG97398.1 - 2.2e-68 226.0 4.8 4.1e-23 80.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Cu-oxidase_2 PF07731.9 KOG97399.1 - 6e-47 158.6 6.0 1e-39 135.1 0.6 3.2 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.10 KOG97399.1 - 2e-43 146.8 7.9 1.5e-40 137.6 0.6 3.9 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.17 KOG97399.1 - 3.1e-35 121.4 10.0 4.4e-32 111.1 1.5 3.7 3 1 0 3 3 3 2 Multicopper oxidase Glycophorin_A PF01102.13 KOG97399.1 - 0.013 15.2 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Glycophorin A Doppel PF11466.3 KOG97399.1 - 0.12 11.9 1.3 0.23 11.0 0.9 1.4 1 0 0 1 1 1 0 Prion-like protein Doppel Sen15 PF09631.5 KOG97400.1 - 1.1e-28 99.4 0.0 1.2e-28 99.2 0.0 1.0 1 0 0 1 1 1 1 Sen15 protein Tom37_C PF11801.3 KOG97401.1 - 1.7e-49 167.9 7.3 1.7e-49 167.9 5.1 1.8 3 0 0 3 3 3 1 Tom37 C-terminal domain Tom37 PF10568.4 KOG97401.1 - 4.3e-23 81.3 0.1 1.3e-22 79.8 0.0 1.9 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein NigD PF12667.2 KOG97401.1 - 0.0014 18.4 1.1 0.0026 17.5 0.8 1.4 1 0 0 1 1 1 1 NigD-like protein Suf PF05843.9 KOG97402.1 - 4.3e-74 249.7 12.8 4.3e-74 249.7 8.9 3.5 2 2 0 2 2 2 1 Suppressor of forked protein (Suf) TPR_11 PF13414.1 KOG97402.1 - 0.0069 16.0 0.4 0.54 9.9 0.0 2.7 2 0 0 2 2 2 1 TPR repeat ArgJ PF01960.13 KOG97403.1 - 7.3e-145 482.2 6.7 8.2e-145 482.0 4.6 1.0 1 0 0 1 1 1 1 ArgJ family SUR7 PF06687.7 KOG97404.1 - 3.2e-25 88.9 14.4 3.9e-25 88.6 9.9 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF2207 PF09972.4 KOG97404.1 - 0.0039 15.8 0.2 0.0053 15.4 0.1 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF1673 PF07895.6 KOG97404.1 - 0.0079 15.7 1.6 0.056 12.9 1.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1673) Fig1 PF12351.3 KOG97404.1 - 0.033 14.0 0.5 0.033 14.0 0.4 3.1 1 1 2 3 3 3 0 Ca2+ regulator and membrane fusion protein Fig1 DUF3661 PF12400.3 KOG97404.1 - 2.6 8.1 11.7 1.1 9.3 3.0 2.6 3 0 0 3 3 3 0 Vaculolar membrane protein DUF4131 PF13567.1 KOG97404.1 - 4.7 6.5 7.4 0.13 11.6 0.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Carot_N PF09150.5 KOG97405.1 - 0.067 12.8 0.0 0.69 9.5 0.0 2.2 2 0 0 2 2 2 0 Orange carotenoid protein, N-terminal Tht1 PF04163.7 KOG97406.1 - 1.2e-181 604.8 22.6 1.3e-181 604.7 15.7 1.0 1 0 0 1 1 1 1 Tht1-like nuclear fusion protein FlaC_arch PF05377.6 KOG97406.1 - 0.071 13.0 0.0 0.071 13.0 0.0 4.4 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) Syntaxin-6_N PF09177.6 KOG97406.1 - 0.13 12.6 9.3 1.5 9.2 0.1 3.9 2 1 2 4 4 4 0 Syntaxin 6, N-terminal Apolipoprotein PF01442.13 KOG97406.1 - 0.15 11.5 1.7 0.67 9.4 1.1 2.0 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain TBPIP PF07106.8 KOG97406.1 - 3.4 7.1 15.0 4.9 6.6 0.0 3.0 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TUG-UBL1 PF11470.3 KOG97408.1 - 5.2e-22 77.5 0.6 1.7e-21 75.8 0.4 2.0 1 0 0 1 1 1 1 GLUT4 regulating protein TUG UBX PF00789.15 KOG97408.1 - 7.7e-16 57.9 0.1 2.5e-15 56.3 0.1 1.9 1 0 0 1 1 1 1 UBX domain RA PF00788.18 KOG97408.1 - 0.0038 17.6 0.3 0.19 12.2 0.0 2.7 3 0 0 3 3 3 1 Ras association (RalGDS/AF-6) domain Ank_2 PF12796.2 KOG97409.1 - 1.4e-41 140.6 8.1 1.2e-13 51.1 0.1 2.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOG97409.1 - 3e-23 81.7 3.5 1.2e-10 41.5 0.1 3.7 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOG97409.1 - 3.7e-23 80.1 6.7 9e-05 22.0 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.1 KOG97409.1 - 1.1e-13 49.9 8.6 0.042 14.1 0.1 5.6 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.1 KOG97409.1 - 2.1e-13 50.0 2.8 0.00022 21.3 0.0 4.3 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Acetyltransf_1 PF00583.19 KOG97410.1 - 9.3e-14 51.2 0.2 1.8e-13 50.2 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 KOG97410.1 - 1.8e-06 27.5 0.0 5.6e-06 26.0 0.0 1.8 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 KOG97410.1 - 0.0006 19.9 0.2 0.0018 18.4 0.1 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KOG97410.1 - 0.005 16.9 0.1 0.0097 16.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 KOG97410.1 - 0.01 15.7 0.1 0.042 13.7 0.1 2.0 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain zf-C2H2 PF00096.21 KOG97411.1 - 6.8e-06 26.1 13.2 0.00016 21.8 3.3 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG97411.1 - 5.1e-05 23.3 11.9 0.00021 21.3 2.8 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.7 KOG97411.1 - 0.00031 20.7 2.9 0.00067 19.7 2.0 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.10 KOG97411.1 - 0.044 13.5 0.4 0.044 13.5 0.3 2.5 2 0 0 2 2 2 0 BED zinc finger zf-H2C2_2 PF13465.1 KOG97411.1 - 0.061 13.6 13.5 1.5 9.2 0.5 3.4 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_2 PF12756.2 KOG97411.1 - 4.6 7.4 14.0 0.84 9.7 0.6 3.1 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Cg6151-P PF10233.4 KOG97412.1 - 4.3e-40 136.2 14.4 5.3e-40 135.9 10.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P ATG22 PF11700.3 KOG97412.1 - 0.13 10.7 8.0 0.2 10.0 5.6 1.3 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like HMG_box PF00505.14 KOG97413.1 - 1.1e-33 115.2 4.9 4e-19 68.6 0.8 2.1 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 KOG97413.1 - 9.2e-17 61.1 3.2 4e-11 43.1 0.6 2.2 2 0 0 2 2 2 2 HMG-box domain DUF1002 PF06207.6 KOG97413.1 - 0.014 14.6 0.4 3.9 6.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1002) CHDNT PF08073.7 KOG97413.1 - 0.088 12.4 0.0 8.9 6.0 0.0 2.8 2 0 0 2 2 2 0 CHDNT (NUC034) domain Syntaxin_2 PF14523.1 KOG97413.1 - 0.1 12.6 6.8 2.8 8.0 0.3 2.7 3 0 0 3 3 3 0 Syntaxin-like protein BBP1_C PF15272.1 KOG97413.1 - 7.7 6.0 10.6 0.31 10.5 1.7 2.4 2 1 0 3 3 3 0 Spindle pole body component BBP1, C-terminal Cyt-b5 PF00173.23 KOG97414.1 - 6.3e-14 51.5 0.0 9.1e-14 51.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain dsDNA_bind PF01984.15 KOG97415.1 - 5.1e-26 90.7 0.0 6e-26 90.5 0.0 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain EF-1_beta_acid PF10587.4 KOG97415.1 - 0.25 11.4 0.1 0.25 11.4 0.1 2.3 3 0 0 3 3 3 0 Eukaryotic elongation factor 1 beta central acidic region PHD PF00628.24 KOG97416.1 - 2.3e-14 52.8 23.8 3.3e-11 42.6 7.6 3.2 2 1 1 3 3 3 2 PHD-finger C1_1 PF00130.17 KOG97416.1 - 0.046 13.4 16.0 0.51 10.1 0.7 3.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.1 KOG97416.1 - 0.17 11.6 0.2 0.17 11.6 0.1 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 HEAT PF02985.17 KOG97417.1 - 6.7e-06 25.7 0.6 6.6 7.0 0.0 5.9 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.1 KOG97417.1 - 0.00034 20.8 0.1 0.14 12.4 0.0 4.5 4 1 2 6 6 6 2 HEAT repeats Snf7 PF03357.16 KOG97418.1 - 7.7e-39 132.8 11.8 1.1e-38 132.3 8.2 1.2 1 0 0 1 1 1 1 Snf7 Mating_N PF12731.2 KOG97418.1 - 0.057 13.2 0.2 0.36 10.7 0.1 2.3 1 1 1 2 2 2 0 Mating-type protein beta 1 HHH_2 PF12826.2 KOG97418.1 - 0.12 12.2 0.3 0.26 11.2 0.0 1.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif SlyX PF04102.7 KOG97418.1 - 0.76 10.1 12.9 0.77 10.1 1.2 2.9 3 1 0 3 3 3 0 SlyX DUF2203 PF09969.4 KOG97418.1 - 3.9 7.7 6.4 1.5 9.0 0.5 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DivIVA PF05103.8 KOG97418.1 - 5.3 7.1 14.8 0.34 10.9 3.9 2.7 2 2 0 2 2 2 0 DivIVA protein DUF948 PF06103.6 KOG97418.1 - 6.4 6.7 6.9 1 9.2 0.8 2.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) AAA PF00004.24 KOG97419.1 - 1.7e-11 44.4 0.4 1.6e-10 41.2 0.0 2.6 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 KOG97419.1 - 6e-10 38.4 2.1 9.6e-05 21.2 0.2 3.0 2 1 0 2 2 2 2 Rad17 cell cycle checkpoint protein RuvB_N PF05496.7 KOG97419.1 - 4.8e-05 22.5 0.0 0.00027 20.0 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 KOG97419.1 - 0.00038 20.3 0.1 0.013 15.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOG97419.1 - 0.0013 18.9 0.1 0.0068 16.5 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KOG97419.1 - 0.0018 19.1 0.0 0.0082 16.9 0.0 2.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOG97419.1 - 0.0026 17.7 0.0 0.006 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 KOG97419.1 - 0.0028 17.5 0.0 0.0075 16.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOG97419.1 - 0.013 15.2 0.0 0.029 14.0 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_18 PF13238.1 KOG97419.1 - 0.018 15.3 0.0 0.25 11.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain Phage_Mu_Gam PF07352.7 KOG97419.1 - 0.023 14.2 1.5 0.39 10.2 0.0 2.9 3 0 0 3 3 3 0 Bacteriophage Mu Gam like protein AAA_5 PF07728.9 KOG97419.1 - 0.032 13.9 0.0 0.11 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.22 KOG97419.1 - 0.039 14.2 3.2 2.5 8.3 0.0 4.2 5 0 0 5 5 5 0 ABC transporter DUF258 PF03193.11 KOG97419.1 - 0.074 12.2 0.0 0.16 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 CRAL_TRIO PF00650.15 KOG97420.1 - 9.1e-37 126.0 0.0 1.3e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 KOG97420.1 - 2.9e-12 46.5 1.8 4.1e-12 46.0 0.4 2.0 2 1 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 KOG97420.1 - 0.0014 18.5 0.1 0.0048 16.8 0.0 1.8 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain UPF1_Zn_bind PF09416.5 KOG97421.1 - 9.2e-71 236.3 8.6 9.2e-71 236.3 6.0 2.3 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.1 KOG97421.1 - 1.5e-57 194.2 0.0 3e-57 193.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KOG97421.1 - 2.3e-52 177.9 0.9 4e-52 177.1 0.6 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 KOG97421.1 - 1.8e-16 60.3 0.1 1e-11 44.8 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.1 KOG97421.1 - 8.5e-13 47.8 0.1 2.8e-12 46.1 0.1 1.9 2 0 0 2 2 2 1 Part of AAA domain DUF2075 PF09848.4 KOG97421.1 - 7.7e-06 25.1 0.2 8.6e-05 21.6 0.0 2.6 2 2 1 3 3 3 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.10 KOG97421.1 - 1.3e-05 25.0 0.3 4.4e-05 23.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.13 KOG97421.1 - 4.8e-05 22.9 0.0 0.51 9.8 0.0 2.9 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.9 KOG97421.1 - 0.003 17.2 0.0 0.0066 16.0 0.0 1.6 1 0 0 1 1 1 1 Helicase PIF1 PF05970.9 KOG97421.1 - 0.004 16.1 0.0 0.61 8.9 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase PhoH PF02562.11 KOG97421.1 - 0.0075 15.5 0.0 0.017 14.3 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein T2SE PF00437.15 KOG97421.1 - 0.017 14.0 0.0 0.03 13.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DEAD PF00270.24 KOG97421.1 - 0.027 13.9 0.0 0.068 12.6 0.0 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase HEM4 PF02602.10 KOG97421.1 - 0.047 12.9 0.0 0.081 12.1 0.0 1.3 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD AAA_16 PF13191.1 KOG97421.1 - 0.065 13.2 0.2 0.065 13.2 0.1 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.1 KOG97421.1 - 0.097 12.8 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ribosomal_S13_N PF08069.7 KOG97421.1 - 0.17 11.7 0.0 0.58 10.0 0.0 1.9 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain ADH_N PF08240.7 KOG97423.1 - 1.9e-30 104.8 0.2 3.5e-30 103.9 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOG97423.1 - 1.3e-26 92.6 0.2 1.9e-26 92.1 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KOG97423.1 - 6e-05 23.9 0.0 0.00017 22.4 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase SIS PF01380.17 KOG97424.1 - 3e-48 162.7 0.0 7.6e-27 93.5 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 KOG97424.1 - 3.2e-21 75.4 0.2 1.9e-15 56.4 0.0 2.6 2 1 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 KOG97424.1 - 2.6e-16 59.8 0.0 5.5e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 KOG97424.1 - 3.5e-11 42.9 0.0 7.9e-11 41.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 KOG97424.1 - 1.6e-08 33.5 0.2 2.8e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.1 KOG97424.1 - 0.036 13.7 0.0 0.085 12.5 0.0 1.6 1 0 0 1 1 1 0 SIS domain Macro_2 PF14519.1 KOG97426.1 - 6.3e-152 504.4 0.0 7.4e-152 504.2 0.0 1.0 1 0 0 1 1 1 1 Macro-like domain Macro PF01661.16 KOG97426.1 - 0.0048 16.7 0.0 0.012 15.4 0.0 1.7 1 1 0 1 1 1 1 Macro domain MFS_1 PF07690.11 KOG97427.1 - 1.8e-40 138.7 38.9 3.6e-40 137.7 26.6 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOG97427.1 - 3.3e-17 62.2 8.9 3.3e-17 62.2 6.2 3.3 3 0 0 3 3 3 2 Sugar (and other) transporter Peptidase_M41 PF01434.13 KOG97428.1 - 7.1e-75 251.1 2.1 1.6e-74 250.0 0.0 2.1 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.24 KOG97428.1 - 3.6e-42 143.7 0.0 8.8e-42 142.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.10 KOG97428.1 - 5.8e-10 39.3 0.4 1.6e-09 37.8 0.3 1.8 1 0 0 1 1 1 1 FtsH Extracellular AAA_17 PF13207.1 KOG97428.1 - 0.00045 21.0 3.0 0.00049 20.8 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_5 PF07728.9 KOG97428.1 - 0.0014 18.3 0.1 0.0065 16.1 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 KOG97428.1 - 0.0022 17.1 0.0 0.0046 16.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 KOG97428.1 - 0.0023 16.7 0.5 0.0059 15.3 0.0 1.8 2 0 0 2 2 2 1 TIP49 C-terminus AAA_2 PF07724.9 KOG97428.1 - 0.003 17.4 0.1 0.012 15.5 0.0 2.0 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_19 PF13245.1 KOG97428.1 - 0.0044 16.7 0.4 0.012 15.3 0.3 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 KOG97428.1 - 0.0085 16.2 0.1 0.16 12.1 0.1 2.6 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 KOG97428.1 - 0.011 15.1 0.0 0.024 14.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.1 KOG97428.1 - 0.034 14.1 0.2 0.15 12.0 0.1 2.0 1 1 1 2 2 2 0 AAA ATPase domain AAA_33 PF13671.1 KOG97428.1 - 0.055 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 KOG97428.1 - 0.062 12.7 1.3 0.25 10.7 0.3 2.2 1 1 1 2 2 2 0 AAA domain DUF384 PF04064.8 KOG97428.1 - 0.1 12.1 0.5 0.3 10.6 0.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF384) CARD PF00619.16 KOG97428.1 - 1.1 9.0 5.2 0.51 10.2 0.2 2.4 2 0 0 2 2 2 0 Caspase recruitment domain NAD_binding_10 PF13460.1 KOG97429.1 - 2.6e-28 99.2 0.1 2.9e-28 99.1 0.1 1.0 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 KOG97429.1 - 2.4e-09 36.7 0.1 1.1e-08 34.6 0.1 1.8 1 1 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.14 KOG97429.1 - 3.9e-09 35.6 1.4 5.5e-09 35.1 1.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.19 KOG97429.1 - 4.8e-07 30.0 0.2 9e-07 29.2 0.1 1.4 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.16 KOG97429.1 - 1.6e-06 27.7 0.3 3.8e-06 26.5 0.2 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.15 KOG97429.1 - 6.5e-05 22.8 0.2 0.00012 21.9 0.2 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Ldh_1_N PF00056.18 KOG97429.1 - 0.00021 21.1 0.9 0.00029 20.6 0.6 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 KOG97429.1 - 0.0073 15.3 0.3 0.011 14.7 0.2 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 KOG97429.1 - 0.0074 16.3 0.1 0.012 15.6 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 KOG97429.1 - 0.014 15.8 0.1 0.036 14.4 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.17 KOG97429.1 - 0.014 15.8 0.2 0.048 14.1 0.0 1.8 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Polysacc_synt_2 PF02719.10 KOG97429.1 - 0.056 12.3 1.0 0.16 10.8 0.7 1.7 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Peripla_BP_6 PF13458.1 KOG97429.1 - 0.061 12.6 0.1 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Periplasmic binding protein RmlD_sub_bind PF04321.12 KOG97429.1 - 0.15 10.9 0.1 0.22 10.3 0.1 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain CRC_subunit PF08624.5 KOG97430.1 - 3.6e-56 188.9 1.7 4.5e-56 188.6 0.0 2.0 2 0 0 2 2 2 1 Chromatin remodelling complex Rsc7/Swp82 subunit WD40 PF00400.27 KOG97431.1 - 1.3e-24 85.1 19.9 0.0021 17.8 0.0 10.9 11 1 0 11 11 11 7 WD domain, G-beta repeat eIF2A PF08662.6 KOG97431.1 - 1.9e-06 27.7 0.2 0.15 11.7 0.0 3.7 3 0 0 3 3 3 3 Eukaryotic translation initiation factor eIF2A UTP15_C PF09384.5 KOG97432.1 - 3.7e-52 175.9 0.2 5.8e-52 175.3 0.2 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.27 KOG97432.1 - 2.7e-23 80.9 2.2 1.7e-06 27.6 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat SNO PF01174.14 KOG97434.1 - 6e-90 299.9 0.0 6.8e-90 299.7 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 KOG97434.1 - 2e-09 37.2 0.0 3.9e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.19 KOG97434.1 - 0.00068 19.1 0.0 0.0017 17.8 0.0 1.6 2 0 0 2 2 2 1 DJ-1/PfpI family DUF4066 PF13278.1 KOG97434.1 - 0.0021 17.3 0.0 0.0034 16.6 0.0 1.2 1 0 0 1 1 1 1 Putative amidotransferase Peptidase_S51 PF03575.12 KOG97434.1 - 0.023 14.4 0.0 0.033 13.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S51 BPL_N PF09825.4 KOG97434.1 - 0.058 12.1 0.0 0.17 10.6 0.0 1.6 2 0 0 2 2 2 0 Biotin-protein ligase, N terminal SOR_SNZ PF01680.12 KOG97435.1 - 1.1e-110 368.1 6.0 1.5e-110 367.7 4.2 1.1 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.9 KOG97435.1 - 3.8e-08 32.7 3.4 3.6e-07 29.5 0.1 2.4 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 KOG97435.1 - 0.0022 17.3 0.1 0.02 14.1 0.0 2.3 2 0 0 2 2 2 1 Histidine biosynthesis protein Dus PF01207.12 KOG97435.1 - 0.0022 16.8 0.3 0.49 9.1 0.0 2.6 2 1 1 3 3 3 2 Dihydrouridine synthase (Dus) NanE PF04131.9 KOG97435.1 - 0.0026 16.7 1.3 0.071 12.0 0.0 2.6 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase TMP-TENI PF02581.12 KOG97435.1 - 0.011 14.9 0.5 0.52 9.4 0.0 2.6 2 1 0 2 2 2 0 Thiamine monophosphate synthase/TENI NMO PF03060.10 KOG97435.1 - 0.022 13.8 2.5 0.025 13.7 0.1 2.2 2 1 0 2 2 2 0 Nitronate monooxygenase 1-cysPrx_C PF10417.4 KOG97435.1 - 0.036 13.7 0.3 1.9 8.1 0.0 2.6 2 0 0 2 2 2 0 C-terminal domain of 1-Cys peroxiredoxin IGPS PF00218.16 KOG97435.1 - 0.037 13.0 0.1 0.21 10.6 0.0 2.1 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase FMN_dh PF01070.13 KOG97435.1 - 0.042 12.6 0.6 0.084 11.7 0.0 1.7 2 0 0 2 2 2 0 FMN-dependent dehydrogenase MMR_HSR1 PF01926.18 KOG97436.1 - 1.3e-14 54.1 0.1 5.4e-14 52.1 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 KOG97436.1 - 0.0005 19.2 0.1 0.0011 18.1 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 KOG97436.1 - 0.0017 17.8 0.0 0.0033 16.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Dynamin_N PF00350.18 KOG97436.1 - 0.0021 17.8 0.0 0.53 10.0 0.0 2.5 1 1 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.22 KOG97436.1 - 0.0027 17.1 0.1 0.0052 16.2 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_25 PF13481.1 KOG97436.1 - 0.0059 16.0 0.1 0.018 14.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.10 KOG97436.1 - 0.0071 16.0 0.1 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 NTPase AAA_18 PF13238.1 KOG97436.1 - 0.0076 16.5 1.4 0.051 13.8 0.0 2.6 3 0 0 3 3 3 1 AAA domain FeoB_N PF02421.13 KOG97436.1 - 0.0089 15.3 0.0 0.13 11.5 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B ArgK PF03308.11 KOG97436.1 - 0.012 14.3 0.3 0.29 9.8 0.0 2.2 1 1 1 2 2 2 0 ArgK protein AAA_23 PF13476.1 KOG97436.1 - 0.034 14.4 0.1 0.067 13.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KOG97436.1 - 0.066 14.0 0.9 0.35 11.6 0.0 2.5 3 1 0 3 3 3 0 AAA domain KTI12 PF08433.5 KOG97436.1 - 0.083 12.0 0.1 0.19 10.8 0.0 1.7 2 0 0 2 2 2 0 Chromatin associated protein KTI12 ATP_bind_1 PF03029.12 KOG97436.1 - 0.12 11.8 0.0 1.7 8.0 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein mRNA_stabil PF13929.1 KOG97437.1 - 1.1e-93 313.3 9.6 1.9e-93 312.6 6.6 1.4 1 0 0 1 1 1 1 mRNA stabilisation Oligomerisation PF02410.10 KOG97437.1 - 3e-16 59.2 0.0 7e-16 58.0 0.0 1.7 1 0 0 1 1 1 1 Oligomerisation domain PRP1_N PF06424.7 KOG97437.1 - 2.2 8.6 5.9 3.4 7.9 2.0 2.6 2 1 0 2 2 2 0 PRP1 splicing factor, N-terminal Aldose_epim PF01263.15 KOG97438.1 - 8.5e-54 182.6 0.2 1e-53 182.3 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase zf-MYND PF01753.13 KOG97439.1 - 3.4e-08 33.2 16.5 3.4e-08 33.2 11.4 1.9 2 0 0 2 2 2 1 MYND finger Prenyltransf PF01255.14 KOG97440.1 - 1.4e-70 236.9 0.1 2.6e-70 236.0 0.1 1.4 2 0 0 2 2 2 1 Putative undecaprenyl diphosphate synthase SHP PF03579.8 KOG97440.1 - 0.074 12.4 1.3 0.21 10.9 0.9 1.8 1 0 0 1 1 1 0 Small hydrophobic protein WD40 PF00400.27 KOG97441.1 - 2.1e-27 93.9 8.6 2.3e-07 30.3 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat Pkinase PF00069.20 KOG97442.1 - 7.1e-67 225.2 0.0 1.2e-66 224.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97442.1 - 1.1e-28 100.0 0.0 1.7e-28 99.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 KOG97442.1 - 2e-10 40.9 0.1 7.2e-10 39.2 0.0 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 KOG97442.1 - 0.0051 15.8 0.0 0.01 14.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG97442.1 - 0.052 12.6 0.1 0.095 11.7 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG97442.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family PGM_PMM_I PF02878.11 KOG97443.1 - 1.3e-36 125.0 0.0 2.3e-36 124.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 KOG97443.1 - 4.5e-26 91.0 0.0 7.8e-26 90.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 KOG97443.1 - 1.2e-13 51.2 0.0 3e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 KOG97443.1 - 1.8e-08 34.2 0.0 4.1e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Ku PF02735.11 KOG97444.1 - 1.3e-40 138.9 0.2 2.7e-40 137.9 0.2 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 KOG97444.1 - 4.5e-37 127.6 3.0 7.8e-37 126.8 2.1 1.4 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.9 KOG97444.1 - 5.8e-09 36.3 1.9 2.9e-08 34.1 0.1 2.8 2 1 0 2 2 2 1 Ku70/Ku80 C-terminal arm MTHFR PF02219.12 KOG97445.1 - 0.12 11.4 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Methylenetetrahydrofolate reductase TPP_enzyme_N PF02776.13 KOG97446.1 - 1.8e-60 203.3 0.1 6.3e-59 198.3 0.1 2.6 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 KOG97446.1 - 1.3e-51 174.2 0.0 1.9e-50 170.4 0.0 2.5 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 KOG97446.1 - 3.3e-36 124.0 0.8 6.8e-36 123.0 0.2 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.14 KOG97446.1 - 0.039 13.4 0.1 0.07 12.6 0.1 1.4 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Myosin_head PF00063.16 KOG97447.1 - 2.7e-224 746.2 9.1 4.2e-224 745.6 6.3 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 KOG97447.1 - 2.4e-51 173.8 0.5 4.1e-50 169.8 0.0 2.3 2 0 0 2 2 2 1 Myosin tail SH3_1 PF00018.23 KOG97447.1 - 2.5e-13 49.1 0.0 5.8e-13 48.0 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOG97447.1 - 5.3e-09 35.5 0.1 1.2e-08 34.3 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOG97447.1 - 1.6e-07 30.6 0.0 4e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain AAA_22 PF13401.1 KOG97447.1 - 0.0032 17.6 0.0 0.011 15.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain SH3_3 PF08239.6 KOG97447.1 - 0.0039 17.3 0.1 0.011 15.9 0.1 1.8 1 0 0 1 1 1 1 Bacterial SH3 domain Zeta_toxin PF06414.7 KOG97447.1 - 0.007 15.4 0.0 0.037 13.1 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin Hpr_kinase_C PF07475.7 KOG97447.1 - 0.018 14.3 0.0 4.7 6.4 0.0 2.6 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_19 PF13245.1 KOG97447.1 - 0.037 13.7 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain NACHT PF05729.7 KOG97447.1 - 0.042 13.4 0.0 0.13 11.9 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_17 PF13207.1 KOG97447.1 - 0.045 14.5 0.1 0.21 12.3 0.0 2.3 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.1 KOG97447.1 - 0.048 13.6 0.0 0.18 11.7 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain IQ PF00612.22 KOG97447.1 - 1.1 9.1 14.5 1.8 8.4 4.3 2.7 1 1 1 2 2 2 0 IQ calmodulin-binding motif DUF605 PF04652.11 KOG97447.1 - 3.7 6.8 22.7 7.5 5.8 15.7 1.4 1 0 0 1 1 1 0 Vta1 like Aldedh PF00171.17 KOG97448.1 - 4.5e-79 265.9 0.0 5.3e-79 265.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family GCR1_C PF12550.3 KOG97449.1 - 2.2e-25 88.3 0.2 4.8e-25 87.2 0.1 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes VirionAssem_T7 PF11653.3 KOG97449.1 - 0.15 12.8 0.0 0.46 11.2 0.0 1.8 1 0 0 1 1 1 0 Bacteriophage T7 virion assembly protein Med11 PF10280.4 KOG97450.1 - 7e-26 90.5 2.9 7.9e-26 90.4 2.0 1.0 1 0 0 1 1 1 1 Mediator complex protein Med2 PF11214.3 KOG97450.1 - 0.042 13.8 2.8 0.088 12.8 1.6 2.0 1 1 1 2 2 2 0 Mediator complex subunit 2 Med29 PF11568.3 KOG97450.1 - 0.073 13.1 0.2 0.093 12.7 0.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 29 DUF4015 PF13200.1 KOG97450.1 - 0.11 11.3 0.0 0.19 10.6 0.0 1.4 1 1 0 1 1 1 0 Putative glycosyl hydrolase domain Fzo_mitofusin PF04799.8 KOG97450.1 - 0.59 9.5 3.0 2 7.7 2.1 1.9 1 1 0 1 1 1 0 fzo-like conserved region Mur_ligase_M PF08245.7 KOG97451.1 - 6.6e-06 26.3 0.0 1.2e-05 25.4 0.0 1.5 1 1 0 1 1 1 1 Mur ligase middle domain DUF159 PF02586.9 KOG97452.1 - 6.4e-56 189.1 0.7 6.4e-56 189.1 0.5 1.6 2 0 0 2 2 2 1 Uncharacterised ACR, COG2135 WD40 PF00400.27 KOG97453.1 - 6e-55 181.2 10.9 9.9e-09 34.7 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 KOG97453.1 - 1.8e-05 24.5 0.6 0.0044 16.7 0.0 3.1 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 KOG97453.1 - 0.00076 17.7 9.0 0.19 9.8 0.2 4.1 1 1 4 5 5 5 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 KOG97453.1 - 0.0031 16.3 0.6 1.4 7.5 0.5 3.5 1 1 0 2 2 2 2 Nup133 N terminal like Gmad2 PF10648.4 KOG97453.1 - 0.076 13.1 0.0 3.5 7.8 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin-like domain of bacterial spore germination Spc24 PF08286.6 KOG97454.1 - 2.1e-27 95.1 5.2 2.1e-27 95.1 3.6 1.9 1 1 1 2 2 2 1 Spc24 subunit of Ndc80 SurA_N_3 PF13624.1 KOG97454.1 - 0.075 13.0 0.9 0.33 10.9 0.1 2.0 2 0 0 2 2 2 0 SurA N-terminal domain Sdh_cyt PF01127.17 KOG97455.1 - 4.3e-25 87.8 1.6 6e-25 87.4 1.1 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit zf-C3HC4_3 PF13920.1 KOG97456.1 - 1.2e-06 28.0 10.8 1.2e-06 28.0 7.5 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Pox_F12L PF03337.8 KOG97456.1 - 0.15 9.9 0.1 0.23 9.3 0.1 1.1 1 0 0 1 1 1 0 Poxvirus F12L protein AICARFT_IMPCHas PF01808.13 KOG97457.1 - 5.4e-121 403.5 0.0 7.4e-121 403.0 0.0 1.2 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.17 KOG97457.1 - 6.6e-25 86.8 0.3 1.3e-24 85.8 0.0 1.7 2 0 0 2 2 2 1 MGS-like domain Ribosomal_L15e PF00827.12 KOG97458.1 - 6.4e-91 303.0 14.9 7.4e-91 302.8 10.3 1.0 1 0 0 1 1 1 1 Ribosomal L15 Renin_r PF07850.9 KOG97459.1 - 0.12 12.7 0.3 0.14 12.5 0.2 1.1 1 0 0 1 1 1 0 Renin receptor-like protein Pex14_N PF04695.8 KOG97459.1 - 0.37 10.8 4.1 0.39 10.7 2.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pkr1 PF08636.5 KOG97460.1 - 7.8e-32 109.1 11.2 9.9e-32 108.8 7.7 1.1 1 0 0 1 1 1 1 ER protein Pkr1 DUF1772 PF08592.6 KOG97460.1 - 0.0022 17.7 0.1 0.0031 17.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Oxidored_q2 PF00420.19 KOG97460.1 - 0.059 12.9 1.4 0.072 12.6 0.4 1.6 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L MgtE PF01769.11 KOG97460.1 - 0.061 13.6 1.1 0.078 13.2 0.8 1.1 1 0 0 1 1 1 0 Divalent cation transporter MIF4G_like_2 PF09090.6 KOG97462.1 - 3.4e-59 200.1 4.8 1.4e-58 198.1 3.3 2.1 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.6 KOG97462.1 - 9.7e-59 198.0 1.1 2.8e-58 196.5 0.8 1.8 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.14 KOG97462.1 - 1.6e-18 66.8 8.8 1.6e-18 66.8 6.1 3.9 3 2 1 4 4 4 1 MIF4G domain BLOC1_2 PF10046.4 KOG97462.1 - 4.2 7.5 10.8 0.57 10.3 0.6 4.0 5 0 0 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3827 PF12877.2 KOG97463.1 - 0.15 10.1 1.3 0.22 9.6 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) MOZ_SAS PF01853.13 KOG97464.1 - 2.9e-68 228.8 1.7 4.4e-68 228.2 1.1 1.3 1 0 0 1 1 1 1 MOZ/SAS family Acetyltransf_1 PF00583.19 KOG97464.1 - 0.058 13.4 0.0 0.55 10.2 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family HA2 PF04408.18 KOG97465.1 - 4.7e-25 87.5 0.0 2.7e-24 85.1 0.0 2.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 KOG97465.1 - 1.6e-17 63.3 0.0 4.4e-17 61.9 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 KOG97465.1 - 1.3e-14 53.7 0.0 2.3e-13 49.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOG97465.1 - 7.8e-08 31.9 0.0 2.2e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KOG97465.1 - 7e-05 22.9 0.6 0.00059 19.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 KOG97465.1 - 0.0053 15.6 0.0 0.012 14.5 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein KaiC PF06745.8 KOG97465.1 - 0.0093 15.0 0.4 0.0093 15.0 0.2 2.5 2 1 1 3 3 3 1 KaiC HAD_2 PF13419.1 KOG97467.1 - 2.1e-13 50.8 0.0 4.2e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOG97467.1 - 9.7e-09 34.8 0.0 2.8e-08 33.3 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like WD40 PF00400.27 KOG97468.1 - 9.9e-19 66.4 10.3 5.7e-07 29.1 0.0 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 KOG97468.1 - 2.9e-18 65.5 0.1 7.2e-18 64.2 0.1 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex PRCC PF10253.4 KOG97468.1 - 0.078 13.6 3.7 0.051 14.2 0.9 1.9 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting DUF814 PF05670.8 KOG97469.1 - 2.8e-22 78.3 0.0 4.7e-22 77.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF814) DUF3551 PF12071.3 KOG97469.1 - 0.066 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3551) CLTH PF10607.4 KOG97471.1 - 5.1e-20 71.6 6.8 5.1e-20 71.6 4.7 2.2 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-CCHH PF10283.4 KOG97471.1 - 0.32 10.8 1.5 0.71 9.7 1.0 1.6 1 0 0 1 1 1 0 Zinc-finger (CX5CX6HX5H) motif GATA PF00320.22 KOG97472.1 - 8.7e-16 56.9 3.4 8.7e-16 56.9 2.4 2.0 2 0 0 2 2 2 1 GATA zinc finger DUF4175 PF13779.1 KOG97472.1 - 0.17 9.5 16.6 0.23 9.1 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DRMBL PF07522.9 KOG97473.1 - 7.2e-25 87.1 0.4 1.6e-24 86.0 0.0 1.8 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 KOG97473.1 - 1.9e-07 30.8 0.1 3.7e-07 29.8 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Nitrophorin PF02087.10 KOG97473.1 - 0.011 15.4 0.0 0.033 13.9 0.0 1.7 1 0 0 1 1 1 0 Nitrophorin Lactamase_B PF00753.22 KOG97473.1 - 0.052 13.1 0.1 0.12 11.9 0.0 1.6 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Arf PF00025.16 KOG97474.1 - 2.5e-51 173.3 0.1 3.1e-51 173.0 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 KOG97474.1 - 3e-13 49.2 2.9 5.9e-08 31.8 0.4 2.8 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 KOG97474.1 - 7.6e-10 38.3 0.0 9.2e-10 38.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 KOG97474.1 - 9e-10 38.1 0.0 1e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.18 KOG97474.1 - 7.3e-08 32.3 0.0 9.7e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KOG97474.1 - 1.7e-05 24.1 0.0 2.1e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 KOG97474.1 - 2.5e-05 23.7 0.0 0.0053 16.2 0.0 2.1 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Miro PF08477.8 KOG97474.1 - 3.3e-05 24.3 0.0 4.4e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein FeoB_N PF02421.13 KOG97474.1 - 0.0001 21.6 0.1 0.00026 20.3 0.1 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B DUF258 PF03193.11 KOG97474.1 - 0.0063 15.7 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 cobW PF02492.14 KOG97474.1 - 0.013 14.9 0.0 1.2 8.5 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 KOG97474.1 - 0.036 12.8 0.0 0.71 8.5 0.0 2.0 2 0 0 2 2 2 0 ArgK protein MobB PF03205.9 KOG97474.1 - 0.1 12.3 0.0 0.46 10.1 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Pkinase PF00069.20 KOG97475.1 - 2.2e-63 213.8 0.0 2.6e-63 213.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97475.1 - 1.2e-26 93.4 0.0 1.6e-26 92.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOG97475.1 - 0.0024 17.6 0.0 0.011 15.4 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 KOG97475.1 - 0.0056 16.2 0.5 0.012 15.2 0.3 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase DUF3989 PF13150.1 KOG97475.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) zf-C3HC4_2 PF13923.1 KOG97476.1 - 1.4 9.0 9.3 8.3 6.5 6.4 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF904 PF06005.7 KOG97477.1 - 0.027 14.7 10.8 0.027 14.7 7.5 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF904) DUF1217 PF06748.7 KOG97477.1 - 0.084 12.9 1.8 0.15 12.1 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1217) Reticulon PF02453.12 KOG97477.1 - 0.13 11.8 0.0 0.32 10.5 0.0 1.7 1 0 0 1 1 1 0 Reticulon Hydrolase_6 PF13344.1 KOG97477.1 - 0.35 10.7 3.1 0.58 10.0 1.1 2.1 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase LMBR1 PF04791.11 KOG97477.1 - 0.88 8.0 3.8 1 7.8 2.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein CtsR PF05848.6 KOG97477.1 - 3.4 7.6 9.4 0.44 10.5 0.1 2.8 2 1 1 3 3 3 0 Firmicute transcriptional repressor of class III stress genes (CtsR) Pyr_redox_2 PF07992.9 KOG97478.1 - 9.7e-27 94.1 0.0 1.8e-16 60.6 0.0 4.1 3 1 1 4 4 4 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOG97478.1 - 4.8e-13 49.3 0.0 3e-12 46.7 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOG97478.1 - 6.3e-06 26.3 0.3 0.0054 16.8 0.0 3.3 2 1 2 4 4 4 3 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KOG97478.1 - 0.014 15.1 0.6 28 4.4 0.0 3.7 3 1 1 4 4 4 0 FAD-NAD(P)-binding WD40 PF00400.27 KOG97479.1 - 1e-32 110.7 5.9 6.6e-10 38.4 0.4 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 KOG97479.1 - 1.4e-06 28.1 0.2 0.076 12.7 0.0 3.4 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 KOG97479.1 - 0.042 12.5 1.6 0.69 8.5 0.1 2.4 2 1 0 2 2 2 0 Nup133 N terminal like EST1 PF10374.4 KOG97480.1 - 0.029 14.3 0.3 0.029 14.3 0.2 2.0 2 0 0 2 2 2 0 Telomerase activating protein Est1 DUF485 PF04341.7 KOG97481.1 - 0.78 9.4 7.6 1 9.1 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF485 Ribophorin_II PF05817.9 KOG97482.1 - 3.7e-06 25.4 1.5 4.5e-06 25.1 1.0 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II DUF2975 PF11188.3 KOG97482.1 - 0.06 13.0 6.1 0.084 12.5 2.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) 2HCT PF03390.10 KOG97482.1 - 0.14 10.4 4.0 0.23 9.7 2.8 1.2 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family Herpes_BMRF2 PF04633.7 KOG97482.1 - 0.28 10.0 8.1 0.018 14.0 2.0 1.5 2 0 0 2 2 2 0 Herpesvirus BMRF2 protein DUF2636 PF11120.3 KOG97482.1 - 2.2 7.8 4.3 0.34 10.4 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2636) Peptidase_S24 PF00717.18 KOG97483.1 - 6e-07 29.0 0.1 1.7e-06 27.5 0.0 1.8 1 1 1 2 2 2 2 Peptidase S24-like Peptidase_S26 PF10502.4 KOG97483.1 - 0.0016 17.9 0.0 0.0087 15.5 0.0 2.0 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 ADH_zinc_N_2 PF13602.1 KOG97484.1 - 1.9e-12 48.2 0.0 3.6e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 KOG97484.1 - 1.4e-06 27.8 0.0 2.8e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOG97484.1 - 1.9e-05 24.3 0.0 4.2e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF2855 PF11017.3 KOG97484.1 - 0.066 12.3 0.0 0.086 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2855) Semialdhyde_dh PF01118.19 KOG97484.1 - 0.12 12.6 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Nup35_RRM PF05172.8 KOG97485.1 - 8.8e-36 121.7 0.0 1.7e-35 120.7 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.1 KOG97485.1 - 0.00013 21.6 0.0 0.00034 20.3 0.0 1.7 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif TFIIA PF03153.8 KOG97485.1 - 1.2 8.9 27.2 0.32 10.8 16.7 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Calpain_III PF01067.17 KOG97486.1 - 0.012 15.3 0.8 0.24 11.0 0.5 2.8 1 1 0 1 1 1 0 Calpain large subunit, domain III MFS_1 PF07690.11 KOG97487.1 - 2e-13 49.7 12.5 2.9e-13 49.2 8.0 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.8 KOG97487.1 - 3.4e-11 42.8 5.3 1.2e-10 41.1 3.6 1.9 1 0 0 1 1 1 1 Nodulin-like PNK3P PF08645.6 KOG97488.1 - 1.1e-46 158.2 0.8 1.2e-46 158.0 0.5 1.0 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase DUF1463 PF07316.6 KOG97488.1 - 0.01 15.4 0.1 0.016 14.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1463) DUF3024 PF11225.3 KOG97488.1 - 0.023 14.5 0.0 0.067 13.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3024) Ribosomal_S8 PF00410.14 KOG97490.1 - 1.4e-20 73.4 0.0 1.6e-20 73.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 DUF1109 PF06532.6 KOG97491.1 - 0.12 11.8 0.8 0.19 11.1 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1109) SprA-related PF12118.3 KOG97491.1 - 8.1 5.6 24.4 0.14 11.4 10.4 2.1 2 0 0 2 2 2 0 SprA-related family DnaJ PF00226.26 KOG97492.1 - 3.4e-26 90.7 1.4 6e-26 89.9 1.0 1.4 1 0 0 1 1 1 1 DnaJ domain E1-E2_ATPase PF00122.15 KOG97493.1 - 1.4e-19 70.1 0.1 5.2e-19 68.1 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 KOG97493.1 - 1.9e-15 57.8 0.5 1.4e-11 45.2 0.4 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOG97493.1 - 5.4e-13 49.5 0.1 1.6e-11 44.7 0.1 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOG97493.1 - 1.6e-11 43.9 0.0 6.2e-11 42.1 0.0 2.1 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 KOG97493.1 - 0.0045 16.5 0.2 0.0045 16.5 0.1 3.1 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Vezatin PF12632.2 KOG97494.1 - 1.7e-30 105.9 13.3 2.7e-30 105.2 9.2 1.3 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes HAD PF12710.2 KOG97494.1 - 0.012 15.8 0.4 0.072 13.2 0.0 2.2 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase LNS2 PF08235.8 KOG97495.1 - 3.1e-73 244.5 0.0 5.1e-73 243.8 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 KOG97495.1 - 2.3e-45 152.7 0.0 9.8e-45 150.7 0.0 2.1 2 0 0 2 2 2 1 lipin, N-terminal conserved region AF1Q PF15017.1 KOG97495.1 - 0.006 16.4 0.1 0.006 16.4 0.0 3.3 3 0 0 3 3 3 1 Drug resistance and apoptosis regulator DUF4266 PF14086.1 KOG97495.1 - 1.4 9.4 5.1 2.2 8.8 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4266) Mito_carr PF00153.22 KOG97496.1 - 1.9e-66 219.8 0.8 1.3e-22 79.2 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DNA_mis_repair PF01119.14 KOG97497.1 - 5.9e-29 99.9 0.2 1.5e-28 98.5 0.1 1.8 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 KOG97497.1 - 9e-13 48.0 0.0 2e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOG97497.1 - 1.1e-10 41.2 0.0 2.2e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Zn_clus PF00172.13 KOG97498.1 - 1.7e-07 31.0 11.4 1.7e-07 31.0 7.9 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldedh PF00171.17 KOG97499.1 - 1.3e-169 564.4 0.0 1.5e-169 564.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 KOG97499.1 - 0.0018 17.0 0.0 0.006 15.3 0.0 1.7 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) Aldedh PF00171.17 KOG97500.1 - 8.2e-169 561.8 0.0 9.2e-169 561.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 KOG97500.1 - 0.0019 17.0 0.0 0.0039 15.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) SPRY PF00622.23 KOG97501.1 - 7.1e-13 48.7 0.1 1.3e-12 47.8 0.1 1.5 1 0 0 1 1 1 1 SPRY domain GCR1_C PF12550.3 KOG97502.1 - 1.1e-23 82.8 1.9 2.2e-23 81.9 1.3 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Orbi_VP6 PF01516.11 KOG97502.1 - 2.8 6.9 12.0 1.5 7.8 6.0 2.0 2 0 0 2 2 2 0 Orbivirus helicase VP6 NOA36 PF06524.7 KOG97502.1 - 6.2 5.9 7.8 11 5.2 5.4 1.3 1 0 0 1 1 1 0 NOA36 protein Mak16 PF04874.9 KOG97503.1 - 1.6 8.8 6.2 0.36 10.9 1.7 1.9 1 1 1 2 2 2 0 Mak16 protein C-terminal region Inhibitor_I34 PF10466.4 KOG97504.1 - 1.5e-31 108.2 8.6 1.6e-31 108.1 5.9 1.0 1 0 0 1 1 1 1 Saccharopepsin inhibitor I34 RB_B PF01857.15 KOG97504.1 - 0.2 11.1 0.6 0.2 11.1 0.4 1.0 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain Vfa1 PF08432.5 KOG97504.1 - 3.1 7.7 7.3 3.1 7.7 5.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 ARID PF01388.16 KOG97505.1 - 3.3e-24 84.5 0.0 6.6e-23 80.3 0.0 3.3 3 0 0 3 3 3 1 ARID/BRIGHT DNA binding domain JmjC PF02373.17 KOG97505.1 - 4.8e-10 39.6 0.2 1.2e-05 25.5 0.1 2.7 2 0 0 2 2 2 2 JmjC domain, hydroxylase PHD PF00628.24 KOG97505.1 - 6.2e-08 32.2 6.2 1.3e-07 31.2 4.3 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.1 KOG97505.1 - 0.099 12.7 2.2 0.23 11.5 1.5 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain C1_1 PF00130.17 KOG97505.1 - 0.28 10.9 5.2 0.68 9.7 3.6 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.1 KOG97505.1 - 1 9.2 6.7 2.8 7.8 4.7 1.8 1 0 0 1 1 1 0 Ring finger domain Cation_efflux PF01545.16 KOG97506.1 - 7.4e-40 136.8 3.5 1.2e-39 136.1 2.4 1.4 1 0 0 1 1 1 1 Cation efflux family MoCF_biosynth PF00994.19 KOG97507.1 - 5.8e-35 119.7 0.0 1.5e-34 118.5 0.0 1.6 2 0 0 2 2 2 1 Probable molybdopterin binding domain DUF2407_C PF13373.1 KOG97508.1 - 0.93 9.4 3.3 0.5 10.2 0.2 2.2 2 0 0 2 2 2 0 DUF2407 C-terminal domain mRNA_triPase PF02940.10 KOG97509.1 - 7.4e-43 146.7 2.8 1.2e-42 146.0 1.9 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain RNase_Zc3h12a PF11977.3 KOG97510.1 - 0.016 15.0 0.1 0.026 14.3 0.0 1.4 1 1 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain zf-C2H2 PF00096.21 KOG97511.1 - 1.4e-11 44.0 8.6 1.1e-05 25.4 0.9 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG97511.1 - 8.4e-11 41.4 7.7 8.8e-05 22.5 0.6 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KOG97511.1 - 2e-09 37.2 2.0 2e-09 37.2 1.4 2.9 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.2 KOG97511.1 - 0.00095 19.2 4.6 0.27 11.5 0.7 2.4 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 KOG97511.1 - 0.00098 18.9 2.5 0.0033 17.2 0.3 2.2 2 0 0 2 2 2 1 C2H2-type zinc finger Homoserine_dh PF00742.14 KOG97511.1 - 0.0078 15.9 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase zf-H2C2_5 PF13909.1 KOG97511.1 - 0.058 13.6 6.4 0.14 12.3 1.0 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-BED PF02892.10 KOG97511.1 - 0.24 11.1 2.1 0.83 9.4 1.5 1.9 1 1 1 2 2 2 0 BED zinc finger SNARE PF05739.14 KOG97512.1 - 1.3e-15 56.8 7.2 1.3e-15 56.8 5.0 2.0 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 KOG97512.1 - 7.7e-05 22.8 7.7 7.7e-05 22.8 5.3 2.6 1 1 2 3 3 3 1 Syntaxin Synaptobrevin PF00957.16 KOG97512.1 - 0.00016 21.1 1.6 0.00016 21.1 1.1 1.9 2 0 0 2 2 2 1 Synaptobrevin T2SF PF00482.18 KOG97512.1 - 0.006 16.4 0.0 0.021 14.7 0.0 1.9 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein F Shisa PF13908.1 KOG97512.1 - 0.0088 16.2 1.2 0.023 14.9 0.8 1.7 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Rifin_STEVOR PF02009.11 KOG97512.1 - 0.0098 15.5 9.8 0.025 14.2 5.8 2.0 1 1 1 2 2 2 1 Rifin/stevor family Orthopox_B11R PF07033.6 KOG97512.1 - 0.079 12.4 2.8 4.5 6.8 0.2 2.7 2 0 0 2 2 2 0 Orthopoxvirus B11R protein DUF4094 PF13334.1 KOG97512.1 - 0.2 12.0 0.2 0.2 12.0 0.1 3.5 3 1 2 5 5 4 0 Domain of unknown function (DUF4094) DUF3753 PF12575.3 KOG97512.1 - 0.38 10.5 3.2 0.72 9.6 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) DUF2116 PF09889.4 KOG97512.1 - 1.5 8.7 4.6 0.29 10.9 0.6 1.8 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) PTA_PTB PF01515.14 KOG97512.1 - 2 7.4 11.3 0.095 11.7 3.0 2.1 2 1 1 3 3 3 0 Phosphate acetyl/butaryl transferase DUF2562 PF10814.3 KOG97512.1 - 4.9 7.1 5.6 3 7.8 1.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2562) DUF2435 PF10363.4 KOG97514.1 - 4.9e-33 112.8 0.1 4.8e-32 109.7 0.1 2.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2435) DUF2411 PF10304.4 KOG97514.1 - 1e-08 34.4 2.9 2.8e-08 33.0 2.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF2411) Nro1 PF12753.2 KOG97514.1 - 0.24 10.3 14.6 0.33 9.8 5.4 2.2 1 1 1 2 2 2 0 Nuclear pore complex subunit Nro1 HSP90 PF00183.13 KOG97515.1 - 5.8e-256 850.0 38.2 6.7e-256 849.7 26.5 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.1 KOG97515.1 - 9.7e-11 41.4 0.0 3.6e-10 39.6 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOG97515.1 - 1e-10 41.3 0.0 1.9e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase KCl_Cotrans_1 PF03522.10 KOG97515.1 - 0.03 13.8 0.2 0.097 12.2 0.1 1.9 1 0 0 1 1 1 0 K-Cl Co-transporter type 1 (KCC1) Peptidase_S10 PF00450.17 KOG97515.1 - 0.087 11.9 1.1 0.18 10.8 0.0 1.9 1 1 1 2 2 2 0 Serine carboxypeptidase RINGv PF12906.2 KOG97516.1 - 0.0017 18.3 6.0 0.0044 17.0 4.2 1.7 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 KOG97516.1 - 0.23 11.3 7.7 0.22 11.3 2.9 2.3 2 0 0 2 2 2 0 Ring finger domain zf-RING_4 PF14570.1 KOG97516.1 - 1.3 8.6 7.8 13 5.4 2.8 2.7 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.3 KOG97516.1 - 3.3 7.7 12.0 14 5.7 0.0 2.5 2 0 0 2 2 2 0 FANCL C-terminal domain Ribosomal_S17 PF00366.15 KOG97517.1 - 1.1e-14 54.2 0.2 1.8e-14 53.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 Siah-Interact_N PF09032.6 KOG97517.1 - 0.075 13.1 0.3 0.075 13.1 0.2 2.7 3 1 0 3 3 3 0 Siah interacting protein, N terminal GDC-P PF02347.11 KOG97518.1 - 1.8e-200 666.0 0.0 3.4e-187 622.4 0.0 2.2 2 0 0 2 2 2 2 Glycine cleavage system P-protein Cys_Met_Meta_PP PF01053.15 KOG97518.1 - 0.0011 17.3 0.0 0.0021 16.4 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 KOG97518.1 - 0.056 12.5 0.0 0.12 11.4 0.0 1.6 1 0 0 1 1 1 0 Beta-eliminating lyase Helicase_Sgs1 PF11408.3 KOG97519.1 - 4.5e-33 112.9 0.1 1.4e-32 111.3 0.0 1.9 1 0 0 1 1 1 1 Sgs1 RecQ helicase RQC PF09382.5 KOG97519.1 - 4.2e-27 93.9 0.1 1e-26 92.6 0.1 1.7 1 0 0 1 1 1 1 RQC domain DEAD PF00270.24 KOG97519.1 - 3.9e-23 81.7 0.1 1.2e-21 76.8 0.0 2.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG97519.1 - 4.4e-21 74.5 0.0 7.1e-19 67.4 0.0 3.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HRDC PF00570.18 KOG97519.1 - 0.022 14.4 0.0 0.063 13.0 0.0 1.8 1 0 0 1 1 1 0 HRDC domain RabGAP-TBC PF00566.13 KOG97521.1 - 6.7e-26 91.0 3.4 6.7e-26 91.0 2.4 2.8 2 1 0 2 2 2 1 Rab-GTPase-TBC domain Ribosomal_L28 PF00830.14 KOG97522.1 - 9.1e-21 73.4 1.3 1.6e-20 72.7 0.9 1.4 1 0 0 1 1 1 1 Ribosomal L28 family DUF4108 PF13390.1 KOG97522.1 - 0.23 11.1 2.3 0.64 9.7 0.4 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF4108) Ribosomal_L36e PF01158.13 KOG97523.1 - 3.5e-37 126.3 3.1 3.8e-37 126.1 2.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Glyco_hydro_63 PF03200.11 KOG97526.1 - 0.00021 19.3 14.5 0.00043 18.2 0.7 4.6 3 2 0 3 3 3 2 Mannosyl oligosaccharide glucosidase V-SNARE_C PF12352.3 KOG97527.1 - 4.7e-22 77.8 2.1 4.7e-22 77.8 1.5 2.4 2 1 1 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.10 KOG97527.1 - 2.4e-19 69.2 4.0 2.4e-19 69.2 2.7 2.3 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.8 KOG97527.1 - 0.00071 19.2 1.4 0.00071 19.2 0.9 2.4 2 1 0 2 2 2 1 Sec20 Myosin_tail_1 PF01576.14 KOG97527.1 - 0.0088 13.8 9.9 0.013 13.2 6.9 1.3 1 0 0 1 1 1 1 Myosin tail DUF1744 PF08490.7 KOG97527.1 - 0.012 14.2 0.6 0.068 11.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1744) CKAP2_C PF15297.1 KOG97527.1 - 0.019 13.8 0.9 0.023 13.5 0.5 1.4 1 1 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus Nsp1_C PF05064.8 KOG97527.1 - 0.02 14.5 3.1 0.02 14.5 2.1 2.8 2 2 1 3 3 3 0 Nsp1-like C-terminal region Snapin_Pallidin PF14712.1 KOG97527.1 - 0.021 15.1 2.8 0.021 15.1 1.9 2.3 2 1 0 2 2 2 0 Snapin/Pallidin Prominin PF05478.6 KOG97527.1 - 0.06 10.8 7.3 0.1 10.1 5.0 1.4 1 1 0 1 1 1 0 Prominin CytochromB561_N PF09786.4 KOG97527.1 - 0.064 11.7 4.5 0.048 12.1 0.5 1.9 1 1 0 2 2 2 0 Cytochrome B561, N terminal Flu_NS2 PF00601.14 KOG97527.1 - 0.11 12.6 1.8 0.14 12.3 0.2 2.0 2 0 0 2 2 2 0 Influenza non-structural protein (NS2) DUF3753 PF12575.3 KOG97527.1 - 0.13 12.1 2.7 18 5.2 1.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) Fusion_gly PF00523.13 KOG97527.1 - 0.14 10.1 6.8 0.45 8.5 0.4 2.5 2 1 1 3 3 3 0 Fusion glycoprotein F0 YqjK PF13997.1 KOG97527.1 - 0.43 10.7 0.1 0.43 10.7 0.0 2.5 4 0 0 4 4 2 0 YqjK-like protein SNARE PF05739.14 KOG97527.1 - 0.73 9.5 8.0 1.5 8.5 0.3 2.6 2 1 0 2 2 2 0 SNARE domain Toxin_52 PF15605.1 KOG97527.1 - 0.88 9.5 6.4 5.6 6.9 0.3 2.9 2 1 1 3 3 3 0 Putative toxin 52 DUF4410 PF14366.1 KOG97527.1 - 2.6 7.7 4.6 0.53 10.0 0.5 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4410) DUF4200 PF13863.1 KOG97527.1 - 9.1 6.2 10.6 2.3 8.1 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) HrpB7 PF09486.5 KOG97528.1 - 0.055 13.3 13.2 0.11 12.3 1.7 3.2 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Cep57_MT_bd PF06657.8 KOG97528.1 - 0.19 11.7 22.3 2 8.4 1.1 4.9 2 1 2 4 4 4 0 Centrosome microtubule-binding domain of Cep57 DUF2525 PF10733.4 KOG97528.1 - 0.28 11.0 3.2 0.54 10.1 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2525) Reo_sigmaC PF04582.7 KOG97528.1 - 0.42 9.7 10.1 0.28 10.2 1.1 2.7 3 0 0 3 3 3 0 Reovirus sigma C capsid protein DUF869 PF05911.6 KOG97528.1 - 2.2 6.3 38.6 0.47 8.6 4.9 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) PMC2NT PF08066.7 KOG97528.1 - 2.7 8.3 8.7 0.6 10.4 1.2 3.3 2 1 1 3 3 3 0 PMC2NT (NUC016) domain Cyclin_N PF00134.18 KOG97529.1 - 5.8e-37 126.0 0.0 1.2e-36 125.1 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Rot1 PF10681.4 KOG97530.1 - 1.5e-97 325.1 0.1 1.7e-97 324.9 0.1 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal XPA_C PF05181.7 KOG97531.1 - 2.2e-26 91.2 0.3 5e-26 90.0 0.2 1.7 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.13 KOG97531.1 - 0.017 14.8 0.8 0.017 14.8 0.6 2.1 2 0 0 2 2 2 0 XPA protein N-terminal FAM110_N PF14161.1 KOG97531.1 - 0.021 15.0 1.9 0.052 13.8 1.3 1.6 1 0 0 1 1 1 0 Centrosome-associated N terminus ERG2_Sigma1R PF04622.7 KOG97532.1 - 6.4e-95 316.4 2.2 7.4e-95 316.2 1.6 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Porin_3 PF01459.17 KOG97533.1 - 8.1e-82 274.5 0.2 9.5e-82 274.3 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin Inp1 PF12634.2 KOG97534.1 - 2.7e-46 156.8 0.9 2.7e-46 156.8 0.6 2.1 2 0 0 2 2 2 1 Inheritance of peroxisomes protein 1 PFK PF00365.15 KOG97535.1 - 9.3e-167 553.0 0.2 9.7e-125 415.1 0.9 2.1 2 0 0 2 2 2 2 Phosphofructokinase Glyoxalase_2 PF12681.2 KOG97535.1 - 0.008 16.7 0.0 0.02 15.5 0.0 1.7 1 0 0 1 1 1 1 Glyoxalase-like domain PhoPQ_related PF10142.4 KOG97536.1 - 0.062 11.7 0.9 0.093 11.1 0.6 1.2 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein TRA-1_regulated PF02343.11 KOG97536.1 - 0.18 11.2 2.9 1.6 8.2 0.4 2.3 2 0 0 2 2 2 0 TRA-1 regulated protein R03H10.4 Carboxyl_trans PF01039.17 KOG97537.1 - 1.8e-171 570.8 0.0 2.4e-171 570.4 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain ACC_central PF08326.7 KOG97537.1 - 4.2e-164 547.4 4.8 5.5e-164 547.0 3.3 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.12 KOG97537.1 - 5e-52 176.2 0.0 9e-52 175.4 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.14 KOG97537.1 - 4.6e-22 78.0 0.0 1.8e-21 76.1 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 KOG97537.1 - 7.5e-17 60.7 0.2 1.9e-16 59.4 0.2 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme CPSase_L_chain PF00289.17 KOG97537.1 - 4.8e-16 58.8 0.0 8.9e-16 57.9 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 KOG97537.1 - 2e-11 43.9 0.0 4.8e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 KOG97537.1 - 3.1e-08 32.7 0.0 1.9e-05 23.5 0.0 2.8 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl_2 PF13533.1 KOG97537.1 - 0.00056 19.5 0.0 0.033 13.8 0.0 2.4 2 0 0 2 2 2 1 Biotin-lipoyl like ATP-grasp_3 PF02655.9 KOG97537.1 - 0.00067 19.5 0.0 0.0015 18.3 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 KOG97537.1 - 0.0023 17.3 0.0 0.0052 16.1 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 KOG97537.1 - 0.031 13.6 0.0 0.082 12.2 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain RnfC_N PF13375.1 KOG97537.1 - 0.073 12.8 0.0 0.28 10.9 0.0 1.9 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain GHMP_kinases_N PF00288.21 KOG97538.1 - 3.1e-23 81.6 0.9 8.7e-23 80.1 0.6 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 KOG97538.1 - 0.00011 22.3 0.3 0.0017 18.5 0.0 2.7 2 1 1 3 3 3 1 GHMP kinases C terminal N2227 PF07942.7 KOG97539.1 - 1.1e-70 237.7 0.2 1.9e-70 236.9 0.0 1.4 2 0 0 2 2 2 1 N2227-like protein DUF1828 PF08861.5 KOG97539.1 - 0.0036 16.9 0.0 0.19 11.4 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function DUF1828 Abhydrolase_1 PF00561.15 KOG97540.1 - 2.3e-11 43.6 0.0 3.7e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOG97540.1 - 3.4e-08 33.6 0.0 4.9e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOG97540.1 - 0.0002 21.1 0.0 0.00041 20.1 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.17 KOG97540.1 - 0.0009 19.0 0.0 0.0015 18.2 0.0 1.4 1 0 0 1 1 1 1 Cutinase DUF915 PF06028.6 KOG97540.1 - 0.0068 15.5 0.0 0.016 14.3 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Lipase_3 PF01764.20 KOG97540.1 - 0.055 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) VirJ PF06057.6 KOG97540.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Tubulin_3 PF14881.1 KOG97541.1 - 4.1e-22 78.5 0.2 1.1e-21 77.1 0.0 1.8 2 0 0 2 2 2 1 Tubulin domain Misat_Tub_SegII PF10644.4 KOG97541.1 - 2.5e-21 75.8 0.4 7.3e-21 74.3 0.3 1.8 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.20 KOG97541.1 - 2.6e-05 24.1 0.1 0.00025 20.9 0.0 2.4 3 0 0 3 3 3 1 Tubulin/FtsZ family, GTPase domain DUF1765 PF08578.5 KOG97541.1 - 0.092 12.8 1.0 0.48 10.4 0.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1765) Myb_DNA-binding PF00249.26 KOG97543.1 - 4e-18 65.1 7.7 7.2e-10 38.7 0.2 3.7 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOG97543.1 - 1.2e-15 57.3 1.8 4.1e-10 39.6 0.4 3.8 2 1 1 3 3 3 2 Myb-like DNA-binding domain Myb_Cef PF11831.3 KOG97543.1 - 2.4e-06 26.9 8.1 2.4e-06 26.9 5.6 3.2 2 2 1 3 3 3 1 pre-mRNA splicing factor component Rap1_C PF11626.3 KOG97543.1 - 0.017 14.9 0.3 0.063 13.1 0.0 2.1 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain PASTA PF03793.14 KOG97543.1 - 0.043 13.4 0.1 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 PASTA domain DUF536 PF04394.9 KOG97543.1 - 0.071 12.8 0.2 0.071 12.8 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function, DUF536 DnaJ PF00226.26 KOG97544.1 - 1.1e-26 92.3 3.5 1.8e-26 91.6 2.4 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 KOG97544.1 - 2.6e-14 52.9 17.7 4.3e-14 52.2 12.3 1.4 1 0 0 1 1 1 1 DnaJ central domain CTDII PF01556.13 KOG97544.1 - 2.7e-13 49.5 0.0 2e-12 46.8 0.0 2.3 3 0 0 3 3 3 1 DnaJ C terminal domain HypA PF01155.14 KOG97544.1 - 0.19 11.3 8.8 0.95 9.1 0.2 2.2 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Cytochrom_C550 PF14495.1 KOG97544.1 - 1.2 8.5 3.9 4.6 6.6 1.0 2.3 2 0 0 2 2 2 0 Cytochrome c-550 domain DUF1924 PF09086.6 KOG97544.1 - 3 7.9 5.5 3.6 7.7 0.7 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1924) Cytochrome_CBB3 PF13442.1 KOG97544.1 - 3.9 7.7 17.5 0.56 10.4 0.4 3.8 3 1 2 5 5 5 0 Cytochrome C oxidase, cbb3-type, subunit III Cytochrome_C7 PF14522.1 KOG97544.1 - 6.5 6.4 14.4 5.3 6.7 2.1 2.7 1 1 1 2 2 2 0 Cytochrome c7 Glyco_hydro_72 PF03198.9 KOG97545.1 - 3.8e-126 420.3 1.1 5.4e-126 419.8 0.8 1.2 1 0 0 1 1 1 1 Glucanosyltransferase Glyco_hydro_2_C PF02836.12 KOG97545.1 - 0.0012 17.8 0.0 0.0028 16.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Tmemb_cc2 PF10267.4 KOG97545.1 - 0.13 10.8 3.0 0.18 10.3 2.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF515 PF04415.7 KOG97545.1 - 5.1 5.2 10.9 7.7 4.6 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Pkinase PF00069.20 KOG97546.1 - 9.3e-42 142.9 0.8 7.3e-22 77.7 0.8 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97546.1 - 7.1e-10 38.3 1.4 3.9e-07 29.4 0.5 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase GMP_synt_C PF00958.17 KOG97547.1 - 5.6e-41 138.1 0.1 1.7e-40 136.5 0.0 1.8 2 0 0 2 2 2 1 GMP synthase C terminal domain GATase PF00117.23 KOG97547.1 - 6e-41 140.0 0.0 1.1e-40 139.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.12 KOG97547.1 - 7.5e-10 38.1 0.1 3.7e-06 26.0 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.8 KOG97547.1 - 3.3e-06 26.7 0.1 3.3e-05 23.4 0.0 2.4 1 1 0 1 1 1 1 Peptidase C26 PAPS_reduct PF01507.14 KOG97547.1 - 0.0049 16.7 0.0 0.0084 15.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family QueC PF06508.8 KOG97547.1 - 0.0061 15.8 0.0 0.19 10.9 0.0 2.2 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 KOG97547.1 - 0.015 13.8 0.1 0.033 12.7 0.0 1.5 1 0 0 1 1 1 0 tRNA methyl transferase ThiI PF02568.9 KOG97547.1 - 0.019 14.4 0.0 0.043 13.2 0.0 1.6 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.14 KOG97547.1 - 0.03 13.3 0.1 0.053 12.5 0.1 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase Asn_synthase PF00733.16 KOG97547.1 - 0.1 12.0 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase ATP_bind_3 PF01171.15 KOG97547.1 - 0.18 11.3 0.0 0.32 10.4 0.0 1.4 1 0 0 1 1 1 0 PP-loop family TRAPPC10 PF12584.3 KOG97548.1 - 3e-13 49.5 0.0 7.7e-13 48.1 0.0 1.7 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 DUF11 PF01345.13 KOG97548.1 - 0.049 13.6 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF11 MFS_1 PF07690.11 KOG97551.1 - 1.8e-10 40.1 28.2 2.7e-06 26.3 6.0 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily FSH1 PF03959.8 KOG97552.1 - 2.7e-57 193.6 0.0 3e-57 193.4 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 KOG97552.1 - 1.7e-10 40.8 0.0 2.1e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOG97552.1 - 1.4e-07 31.6 0.0 0.00041 20.2 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 KOG97552.1 - 9e-06 25.2 0.0 4.3e-05 23.0 0.0 2.0 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase BAAT_C PF08840.6 KOG97552.1 - 0.16 11.6 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal UCH PF00443.24 KOG97553.1 - 3.9e-64 216.3 8.0 6.6e-64 215.6 5.5 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOG97553.1 - 2.7e-31 109.1 7.4 4e-31 108.5 5.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 KOG97553.1 - 1e-10 41.5 11.2 1e-10 41.5 7.8 3.4 3 1 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein Mre11_DNA_bind PF04152.9 KOG97554.1 - 3.5e-53 180.0 0.3 3.5e-53 180.0 0.2 2.1 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 KOG97554.1 - 4e-26 91.6 2.3 5.9e-26 91.0 1.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOG97554.1 - 0.00028 20.7 0.0 0.00077 19.3 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain adh_short PF00106.20 KOG97556.1 - 5.3e-33 114.2 0.0 7e-33 113.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOG97556.1 - 6e-14 52.3 0.1 7.7e-14 52.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOG97556.1 - 1.1e-11 44.7 0.0 1.4e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 KOG97556.1 - 0.00023 20.8 0.3 0.00046 19.9 0.2 1.4 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.16 KOG97556.1 - 0.0051 16.2 0.0 0.0084 15.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 KOG97556.1 - 0.03 13.2 0.2 0.093 11.6 0.1 2.0 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 KOG97556.1 - 0.031 14.3 0.3 0.055 13.4 0.2 1.6 1 1 0 1 1 1 0 NADH(P)-binding UBA_4 PF14555.1 KOG97556.1 - 0.031 13.8 0.0 0.063 12.8 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain MreB_Mbl PF06723.8 KOG97556.1 - 0.041 12.4 0.1 0.075 11.6 0.1 1.4 1 0 0 1 1 1 0 MreB/Mbl protein DUF1776 PF08643.5 KOG97556.1 - 0.091 11.8 0.0 0.53 9.3 0.0 1.9 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) Saccharop_dh PF03435.13 KOG97556.1 - 0.095 11.6 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Shikimate_DH PF01488.15 KOG97556.1 - 0.16 12.1 2.1 0.18 11.8 0.5 1.9 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase TAFII55_N PF04658.8 KOG97557.1 - 3.8e-57 192.3 0.6 3.8e-57 192.3 0.4 2.8 3 1 0 3 3 3 1 TAFII55 protein conserved region RrnaAD PF00398.15 KOG97558.1 - 2.9e-75 252.6 0.0 3.3e-75 252.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase S1 PF00575.18 KOG97559.1 - 2.5e-64 213.2 40.0 2.8e-15 56.1 0.3 12.1 12 1 0 12 12 12 10 S1 RNA binding domain TPR_19 PF14559.1 KOG97559.1 - 6.2e-07 29.6 0.0 0.31 11.4 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOG97559.1 - 3.8e-05 23.9 0.3 0.43 11.3 0.0 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOG97559.1 - 4.2e-05 24.0 0.0 0.97 10.1 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat Suf PF05843.9 KOG97559.1 - 0.0028 17.4 0.0 0.0028 17.4 0.0 4.5 4 1 2 6 6 6 3 Suppressor of forked protein (Suf) S10_plectin PF03501.10 KOG97560.1 - 3.8e-43 145.2 0.9 4.3e-43 145.0 0.7 1.0 1 0 0 1 1 1 1 Plectin/S10 domain DUF505 PF04458.7 KOG97560.1 - 0.018 13.2 0.5 0.02 13.0 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF505) YjcQ PF09639.5 KOG97560.1 - 0.023 14.8 0.4 0.035 14.1 0.3 1.3 1 0 0 1 1 1 0 YjcQ protein tRNA-synt_1c_C PF03950.13 KOG97560.1 - 0.028 14.1 0.1 0.03 13.9 0.1 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), anti-codon binding domain HTH_45 PF14947.1 KOG97560.1 - 0.033 14.0 0.9 0.049 13.4 0.2 1.6 2 0 0 2 2 2 0 Winged helix-turn-helix PadR PF03551.9 KOG97560.1 - 0.61 9.8 6.1 0.093 12.5 1.5 1.8 2 1 0 2 2 2 0 Transcriptional regulator PadR-like family VPS11_C PF12451.3 KOG97561.1 - 6.6e-13 48.3 0.1 1.9e-12 46.8 0.1 1.9 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3HC4_2 PF13923.1 KOG97561.1 - 0.00018 21.4 5.4 0.0006 19.7 3.7 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOG97561.1 - 0.0022 18.0 3.8 0.0086 16.1 2.6 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 KOG97561.1 - 0.0032 17.2 1.7 0.0071 16.1 1.2 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 KOG97561.1 - 0.0038 17.0 5.8 0.0038 17.0 4.0 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 KOG97561.1 - 0.007 16.0 6.1 0.032 13.8 4.2 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOG97561.1 - 0.012 15.3 8.5 0.032 13.9 4.3 2.7 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.1 KOG97561.1 - 0.056 13.1 1.7 0.2 11.4 1.2 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 KOG97561.1 - 0.067 13.0 8.6 0.045 13.6 3.9 2.4 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 KOG97561.1 - 0.1 12.2 6.4 0.029 14.0 2.2 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.1 KOG97561.1 - 0.25 11.1 2.6 0.14 11.9 0.2 1.8 2 0 0 2 2 1 0 Prokaryotic RING finger family 1 PHD PF00628.24 KOG97561.1 - 0.41 10.3 10.3 0.016 14.8 2.9 1.9 2 0 0 2 2 2 0 PHD-finger SWIB PF02201.13 KOG97563.1 - 2.3e-30 104.1 0.2 7.2e-29 99.2 0.1 2.4 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.6 KOG97563.1 - 1.4e-10 40.7 0.0 6.8e-10 38.5 0.0 2.1 2 0 0 2 2 2 1 DEK C terminal domain RNase_H PF00075.19 KOG97564.1 - 3.6e-28 98.5 0.0 7.4e-28 97.5 0.0 1.5 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.11 KOG97564.1 - 5e-23 80.8 5.9 4.1e-17 61.9 1.2 2.5 2 0 0 2 2 2 2 Caulimovirus viroplasmin MRG PF05712.8 KOG97564.1 - 0.034 13.0 0.2 0.06 12.2 0.1 1.3 1 0 0 1 1 1 0 MRG RVT_3 PF13456.1 KOG97564.1 - 0.14 11.9 0.0 3.1 7.6 0.0 2.6 2 0 0 2 2 2 0 Reverse transcriptase-like LRR_6 PF13516.1 KOG97565.1 - 4.8e-10 38.4 10.1 0.039 14.0 0.0 8.4 9 0 0 9 9 9 3 Leucine Rich repeat LRR_4 PF12799.2 KOG97565.1 - 2.3e-06 27.0 16.1 0.33 10.6 1.4 6.3 4 2 3 7 7 7 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOG97565.1 - 2.1e-05 23.9 11.8 18 5.8 0.0 7.8 8 1 1 9 9 9 1 Leucine Rich Repeat LRR_8 PF13855.1 KOG97565.1 - 2.3e-05 24.0 13.3 0.95 9.2 0.9 5.6 4 1 1 5 5 5 3 Leucine rich repeat LRR_7 PF13504.1 KOG97565.1 - 0.45 10.9 9.1 61 4.5 0.0 6.4 7 0 0 7 7 7 0 Leucine rich repeat Nucleoplasmin PF03066.10 KOG97565.1 - 0.67 9.4 12.4 1.2 8.6 8.6 1.4 1 0 0 1 1 1 0 Nucleoplasmin TFIID-31kDa PF02291.10 KOG97566.1 - 4.9e-56 188.0 0.0 5.6e-56 187.8 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit ChAPs PF09295.5 KOG97567.1 - 2.2e-171 570.0 4.1 2.7e-171 569.6 2.8 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_11 PF13414.1 KOG97567.1 - 0.094 12.3 0.6 1.2 8.8 0.2 2.5 2 0 0 2 2 2 0 TPR repeat TPR_16 PF13432.1 KOG97567.1 - 0.13 12.9 0.0 41 5.0 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_hydro_76 PF03663.9 KOG97568.1 - 1.7e-147 491.6 17.4 2.1e-147 491.3 12.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Ribonuclease_3 PF00636.21 KOG97569.1 - 3.8e-19 69.2 0.2 1.9e-18 66.9 0.0 2.2 2 0 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 KOG97569.1 - 8.3e-15 54.8 0.0 2.2e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.20 KOG97569.1 - 8.1e-07 29.5 0.0 2e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif DUF382 PF04037.8 KOG97570.1 - 4.3e-50 168.8 0.6 9.4e-50 167.7 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.11 KOG97570.1 - 2.3e-21 74.8 1.2 3.9e-21 74.1 0.8 1.4 1 0 0 1 1 1 1 PSP Mito_carr PF00153.22 KOG97571.1 - 7.6e-29 99.2 6.5 1.4e-12 47.1 0.0 3.3 2 1 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L18ae PF01775.12 KOG97572.1 - 2.8e-44 149.9 3.2 4.7e-44 149.2 2.2 1.3 1 0 0 1 1 1 1 Ribosomal L18ae/LX protein domain Cation_efflux PF01545.16 KOG97573.1 - 5.5e-83 278.3 4.5 7.3e-83 277.9 3.1 1.1 1 0 0 1 1 1 1 Cation efflux family TcpE PF12648.2 KOG97573.1 - 0.52 10.4 2.7 6.8 6.8 0.1 2.5 1 1 1 2 2 2 0 TcpE family SUN PF03856.8 KOG97574.1 - 1.7e-80 269.9 20.4 2e-80 269.6 14.1 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) DUF333 PF03891.10 KOG97574.1 - 0.026 14.3 0.5 0.026 14.3 0.4 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF333) COX6B PF02297.12 KOG97575.1 - 9.8e-23 79.9 3.0 1.3e-22 79.5 2.1 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb s48_45 PF07422.8 KOG97575.1 - 0.078 13.0 0.6 0.094 12.8 0.4 1.2 1 0 0 1 1 1 0 Sexual stage antigen s48/45 domain AMP-binding PF00501.23 KOG97576.1 - 3.1e-79 266.3 0.0 4.4e-79 265.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 KOG97576.1 - 0.018 16.0 0.2 0.099 13.6 0.0 2.3 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain DUF1488 PF07369.6 KOG97576.1 - 0.13 12.0 0.0 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1488) zf-RING_2 PF13639.1 KOG97577.1 - 3.2e-08 33.2 6.7 6e-08 32.4 4.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOG97577.1 - 4e-07 30.0 3.7 1e-06 28.7 2.5 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger FANCL_C PF11793.3 KOG97577.1 - 1.5e-05 24.8 4.3 4.2e-05 23.4 3.0 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain zf-Apc11 PF12861.2 KOG97577.1 - 0.00038 20.2 1.7 0.00097 18.9 1.2 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 KOG97577.1 - 0.015 14.9 7.7 0.029 14.0 5.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.2 KOG97577.1 - 0.035 14.1 6.2 0.069 13.2 4.3 1.5 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4_2 PF13923.1 KOG97577.1 - 0.079 12.9 8.1 0.18 11.8 5.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOG97577.1 - 0.17 11.5 6.4 3.1 7.5 4.5 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.6 KOG97577.1 - 0.3 11.0 6.4 0.56 10.2 4.4 1.5 1 0 0 1 1 1 0 RING-like domain zf-UDP PF14569.1 KOG97577.1 - 0.36 10.5 2.3 9.5 6.0 0.2 2.5 1 1 1 2 2 2 0 Zinc-binding RING-finger C1_1 PF00130.17 KOG97577.1 - 2.2 8.0 5.3 5.4 6.8 3.7 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Pyridoxal_deC PF00282.14 KOG97578.1 - 2e-53 181.1 0.0 3.1e-53 180.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain GST_N_2 PF13409.1 KOG97579.1 - 2.7e-22 78.5 0.0 9.8e-22 76.7 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOG97579.1 - 1.9e-12 46.8 0.0 3.9e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOG97579.1 - 5e-05 23.2 0.1 0.00019 21.3 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOG97579.1 - 0.00095 19.6 0.0 0.0017 18.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 KOG97579.1 - 0.02 15.1 0.1 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain DUF1206 PF06724.6 KOG97580.1 - 0.076 12.7 3.6 0.093 12.4 2.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1206) SR-25 PF10500.4 KOG97581.1 - 0.096 12.1 3.1 0.12 11.8 2.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein EamA PF00892.15 KOG97582.1 - 1.6e-27 96.0 25.3 7.6e-17 61.5 3.1 2.3 2 0 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 KOG97582.1 - 7.5e-09 35.7 6.7 7.5e-09 35.7 4.7 3.0 2 1 1 3 3 3 1 Multidrug resistance efflux transporter DUF914 PF06027.7 KOG97582.1 - 0.00038 19.4 9.8 0.00038 19.4 6.8 1.4 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) UAA PF08449.6 KOG97582.1 - 0.00065 18.7 3.1 0.00065 18.7 2.1 2.3 1 1 0 2 2 2 2 UAA transporter family UPF0060 PF02694.10 KOG97582.1 - 0.051 13.6 10.2 3 7.8 3.7 3.1 2 1 1 3 3 3 0 Uncharacterised BCR, YnfA/UPF0060 family TPT PF03151.11 KOG97582.1 - 3.8 7.1 18.9 0.014 15.0 2.7 3.2 2 1 2 4 4 4 0 Triose-phosphate Transporter family CENP-T PF15511.1 KOG97583.1 - 0.14 11.3 16.9 0.13 11.4 11.2 1.2 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T DUF966 PF06136.8 KOG97583.1 - 1.5 8.1 17.5 1.9 7.8 12.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Utp14 PF04615.8 KOG97583.1 - 2 6.4 32.6 2.5 6.1 22.6 1.0 1 0 0 1 1 1 0 Utp14 protein CDC45 PF02724.9 KOG97583.1 - 4 5.3 13.9 5.2 4.9 9.6 1.1 1 0 0 1 1 1 0 CDC45-like protein vMSA PF00695.14 KOG97583.1 - 9.6 5.2 12.0 12 5.0 8.3 1.2 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus COX7a PF02238.10 KOG97584.1 - 0.091 12.5 0.5 0.12 12.1 0.4 1.4 1 1 0 1 1 1 0 Cytochrome c oxidase subunit VIIa F-box-like PF12937.2 KOG97586.1 - 0.00011 21.8 0.0 0.00032 20.3 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 KOG97586.1 - 0.018 14.6 0.0 0.065 12.9 0.0 2.0 1 0 0 1 1 1 0 F-box domain DUF2428 PF10350.4 KOG97587.1 - 8.9e-65 218.2 0.0 2e-64 217.0 0.0 1.7 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.17 KOG97587.1 - 4.7e-05 23.1 0.1 0.24 11.5 0.0 4.4 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.1 KOG97587.1 - 0.00045 20.4 0.0 0.27 11.5 0.0 3.3 2 1 1 3 3 3 2 HEAT repeats eIF-1a PF01176.14 KOG97588.1 - 4.7e-27 93.2 0.2 6.5e-27 92.7 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myb_DNA-bind_6 PF13921.1 KOG97588.1 - 0.02 15.0 0.0 0.037 14.1 0.0 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain Glyco_transf_20 PF00982.16 KOG97589.1 - 1.1e-176 587.9 2.9 1.1e-176 587.9 2.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 KOG97589.1 - 7e-47 159.3 0.0 1.3e-46 158.4 0.0 1.5 1 0 0 1 1 1 1 Trehalose-phosphatase TatD_DNase PF01026.16 KOG97590.1 - 6e-47 159.9 0.0 7.3e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase SAP30_Sin3_bdg PF13867.1 KOG97591.1 - 8.2e-13 48.0 0.3 2.4e-10 40.0 0.1 2.3 2 0 0 2 2 2 2 Sin3 binding region of histone deacetylase complex subunit SAP30 CUE PF02845.11 KOG97592.1 - 1.5e-11 43.4 0.0 2.5e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 CUE domain DUF2410 PF10307.4 KOG97593.1 - 4.8e-59 199.0 0.0 7.9e-59 198.3 0.0 1.4 1 0 0 1 1 1 1 Hypothetical protein (DUF2410) DUF221 PF02714.10 KOG97594.1 - 8.9e-109 363.2 24.7 8.9e-109 363.2 17.1 2.0 2 0 0 2 2 2 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 KOG97594.1 - 5.6e-39 133.2 1.2 5.6e-39 133.2 0.8 3.1 5 0 0 5 5 5 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 KOG97594.1 - 8.2e-27 92.9 0.1 2.4e-26 91.4 0.0 1.9 1 0 0 1 1 1 1 Phosphate metabolism protein DUF4463 PF14703.1 KOG97594.1 - 2.4e-15 56.7 0.1 4.3e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) Tegument_dsDNA PF12818.2 KOG97594.1 - 0.023 13.5 0.2 0.04 12.7 0.1 1.3 1 0 0 1 1 1 0 dsDNA viral tegument protein Pyrophosphatase PF00719.14 KOG97595.1 - 7.4e-51 171.6 0.0 1e-50 171.2 0.0 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase RRM_1 PF00076.17 KOG97596.1 - 1.7e-41 139.7 4.1 6.7e-14 51.2 0.1 4.3 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG97596.1 - 7.2e-33 112.3 2.0 9.7e-10 38.2 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG97596.1 - 7.3e-11 41.7 2.1 8.8e-05 22.2 0.1 3.8 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lsm_interact PF05391.6 KOG97596.1 - 1.9e-09 36.5 2.3 4e-09 35.5 1.6 1.6 1 0 0 1 1 1 1 Lsm interaction motif Nup35_RRM_2 PF14605.1 KOG97596.1 - 1.1e-07 31.4 0.1 0.023 14.4 0.0 3.1 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 KOG97596.1 - 0.046 13.4 0.0 0.77 9.5 0.0 2.6 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DbpA PF03880.10 KOG97596.1 - 0.084 12.5 0.2 8.8 6.0 0.0 2.7 2 0 0 2 2 2 0 DbpA RNA binding domain G-patch PF01585.18 KOG97597.1 - 0.0083 15.8 2.6 0.057 13.2 1.8 2.4 1 1 0 1 1 1 1 G-patch domain Zip PF02535.17 KOG97597.1 - 1.6 7.6 7.8 2.1 7.2 5.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter CRT10 PF08728.5 KOG97597.1 - 4.1 5.2 11.6 4.3 5.2 8.1 1.0 1 0 0 1 1 1 0 CRT10 RR_TM4-6 PF06459.7 KOG97597.1 - 7.4 6.3 17.5 9.4 6.0 12.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hex_IIIa PF02455.11 KOG97597.1 - 8.7 4.8 8.9 10 4.6 6.2 1.1 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) Paramyxo_ncap PF00973.14 KOG97597.1 - 8.8 4.8 10.0 10 4.6 6.9 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein RRN9 PF10680.4 KOG97598.1 - 1.2e-18 66.5 0.6 2.9e-18 65.3 0.4 1.6 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor Pribosyltran PF00156.22 KOG97599.1 - 2.1e-16 59.8 0.2 3.7e-16 58.9 0.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain SPRY PF00622.23 KOG97599.1 - 0.056 13.5 0.0 0.1 12.6 0.0 1.5 1 1 0 1 1 1 0 SPRY domain Dsl1_N PF11988.3 KOG97599.1 - 0.078 11.8 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 N terminal Cyt-b5 PF00173.23 KOG97601.1 - 1e-22 79.6 0.2 2.5e-22 78.4 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.8 KOG97601.1 - 7.4e-11 42.4 15.2 7.4e-11 42.4 10.5 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Zds_C PF08632.5 KOG97602.1 - 3.1e-33 112.9 2.3 5.8e-33 112.0 1.6 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term Helicase_C PF00271.26 KOG97602.1 - 0.034 14.0 0.7 0.19 11.6 0.0 2.6 3 0 0 3 3 3 0 Helicase conserved C-terminal domain Abi PF02517.11 KOG97603.1 - 1.2e-11 44.5 6.9 1.2e-11 44.5 4.8 2.1 2 1 0 2 2 2 1 CAAX protease self-immunity Bul1_N PF04425.7 KOG97604.1 - 1.2e-161 538.2 0.1 1.2e-161 538.2 0.1 1.8 2 0 0 2 2 2 1 Bul1 N terminus Bul1_C PF04426.7 KOG97604.1 - 1.3e-115 385.3 10.5 1.3e-115 385.3 7.3 2.2 2 0 0 2 2 2 1 Bul1 C terminus ubiquitin PF00240.18 KOG97605.1 - 2.1e-23 81.5 0.1 3.1e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 KOG97605.1 - 1.9e-12 46.6 0.0 2.9e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.26 KOG97605.1 - 2.9e-07 30.1 0.0 7.3e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Ubiquitin_2 PF14560.1 KOG97605.1 - 2.3e-05 24.5 0.0 4.9e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 KOG97605.1 - 7.3e-05 22.6 0.0 0.00021 21.1 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 KOG97605.1 - 0.033 14.3 0.0 0.062 13.5 0.0 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain NIF PF03031.13 KOG97606.1 - 1.1e-23 83.6 0.3 1.7e-22 79.7 0.0 3.0 1 1 0 2 2 2 1 NLI interacting factor-like phosphatase BRCT PF00533.21 KOG97606.1 - 5.1e-13 48.9 0.2 1.7e-12 47.2 0.1 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 KOG97606.1 - 2.8e-08 33.4 0.0 5.9e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain OmpH PF03938.9 KOG97606.1 - 0.056 13.3 16.6 0.76 9.6 8.1 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) ATP-synt_J PF04911.7 KOG97606.1 - 0.13 11.7 0.4 0.29 10.5 0.3 1.5 1 0 0 1 1 1 0 ATP synthase j chain PGM_PMM_I PF02878.11 KOG97607.1 - 5.1e-40 136.1 0.1 1.3e-39 134.8 0.0 1.7 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 KOG97607.1 - 2.8e-17 62.9 0.0 6.6e-17 61.7 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 KOG97607.1 - 2.6e-11 43.5 0.0 4.3e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.15 KOG97607.1 - 2.6e-06 27.3 0.0 6.2e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain MFS_1 PF07690.11 KOG97608.1 - 4.7e-36 124.2 52.1 2.9e-34 118.3 36.1 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOG97608.1 - 2.4e-05 23.1 3.3 2.4e-05 23.1 2.3 4.0 3 1 0 4 4 4 3 Sugar (and other) transporter UPF0233 PF06781.7 KOG97608.1 - 1 9.0 8.3 4.9 6.8 1.5 3.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0233) Fungal_trans PF04082.13 KOG97609.1 - 7e-37 126.7 2.6 7e-37 126.7 1.8 3.0 3 0 0 3 3 3 2 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG97609.1 - 8.8e-11 41.5 12.1 1.8e-10 40.5 8.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain bZIP_2 PF07716.10 KOG97609.1 - 0.14 11.9 2.8 0.099 12.4 0.3 2.0 2 0 0 2 2 2 0 Basic region leucine zipper bZIP_1 PF00170.16 KOG97609.1 - 0.28 11.1 4.5 0.076 12.9 0.2 2.2 2 0 0 2 2 2 0 bZIP transcription factor PIG-L PF02585.12 KOG97610.1 - 3.2e-20 72.9 0.0 5.3e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase ATP13 PF12921.2 KOG97611.1 - 1.8e-39 133.9 0.7 4.3e-39 132.7 0.1 2.0 2 0 0 2 2 2 1 Mitochondrial ATPase expression Init_tRNA_PT PF04179.7 KOG97612.1 - 1.2e-156 522.1 0.5 1.3e-156 521.9 0.4 1.0 1 0 0 1 1 1 1 Initiator tRNA phosphoribosyl transferase Ku_N PF03731.10 KOG97613.1 - 1.5e-46 158.6 1.0 1.5e-46 158.6 0.7 1.8 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.11 KOG97613.1 - 9.8e-36 123.0 0.1 1.7e-35 122.2 0.1 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.9 KOG97613.1 - 3e-18 66.1 4.5 4.2e-17 62.4 0.6 2.8 3 0 0 3 3 3 1 Ku70/Ku80 C-terminal arm VWA PF00092.23 KOG97613.1 - 0.00032 20.4 0.0 0.00063 19.5 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Exo_endo_phos PF03372.18 KOG97614.1 - 3.1e-23 83.0 0.2 4e-23 82.6 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ribosomal_L30 PF00327.15 KOG97615.1 - 6.3e-15 54.4 0.4 3e-14 52.3 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e DUF3945 PF13101.1 KOG97615.1 - 0.13 11.5 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3945) RNB PF00773.14 KOG97616.1 - 4.3e-71 239.8 0.0 8.2e-71 238.9 0.0 1.5 1 0 0 1 1 1 1 RNB domain HEAT_2 PF13646.1 KOG97617.1 - 4.8e-11 42.8 0.3 0.05 13.8 0.0 6.8 5 2 1 6 6 6 2 HEAT repeats HEAT PF02985.17 KOG97617.1 - 1.3e-09 37.2 11.1 3.7 7.8 0.0 8.8 10 0 0 10 10 10 4 HEAT repeat HEAT_EZ PF13513.1 KOG97617.1 - 5.1e-05 23.6 1.3 77 3.9 0.0 8.0 9 2 2 11 11 11 0 HEAT-like repeat Adaptin_N PF01602.15 KOG97617.1 - 0.00013 20.4 4.2 0.0028 16.0 0.5 2.8 3 0 0 3 3 3 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.2 KOG97617.1 - 0.00049 20.4 0.2 0.32 11.4 0.0 4.8 4 2 2 6 6 6 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.2 KOG97617.1 - 0.011 15.5 3.4 16 5.2 0.1 5.1 4 1 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Aminotran_4 PF01063.14 KOG97618.1 - 1.3e-22 80.4 0.0 1.9e-22 79.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class IV Cbl_N PF02262.11 KOG97618.1 - 0.047 13.3 0.6 0.09 12.4 0.4 1.4 1 0 0 1 1 1 0 CBL proto-oncogene N-terminal domain 1 DEAD PF00270.24 KOG97619.1 - 7e-44 149.2 0.5 3.2e-43 147.1 0.0 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG97619.1 - 1.2e-21 76.3 0.0 2.7e-21 75.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 KOG97619.1 - 2.8e-21 74.7 0.3 5.5e-21 73.8 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) SecA_DEAD PF07517.9 KOG97619.1 - 0.00098 18.4 0.0 0.003 16.9 0.0 1.7 1 1 0 1 1 1 1 SecA DEAD-like domain ResIII PF04851.10 KOG97619.1 - 0.0055 16.5 0.1 0.022 14.5 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOG97619.1 - 0.019 15.0 1.1 0.16 12.1 0.6 2.7 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.20 KOG97620.1 - 3.8e-52 177.0 1.1 3.8e-52 177.0 0.8 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97620.1 - 8.3e-25 87.3 0.6 4e-22 78.5 0.2 3.1 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG97620.1 - 0.049 12.5 0.8 0.96 8.3 0.0 2.3 2 0 0 2 2 2 0 Kinase-like DUF4062 PF13271.1 KOG97620.1 - 0.25 11.3 1.4 70 3.5 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4062) Got1 PF04178.7 KOG97621.1 - 4.6e-16 58.9 4.3 5.5e-16 58.7 3.0 1.0 1 0 0 1 1 1 1 Got1/Sft2-like family DUF973 PF06157.6 KOG97621.1 - 0.086 11.7 2.3 0.11 11.4 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF973) GtrA PF04138.9 KOG97621.1 - 0.1 12.5 3.7 0.13 12.2 2.6 1.3 1 0 0 1 1 1 0 GtrA-like protein YrhK PF14145.1 KOG97621.1 - 0.2 11.3 6.3 0.58 9.8 3.9 2.2 1 1 1 2 2 2 0 YrhK-like protein PEMT PF04191.8 KOG97621.1 - 0.24 11.5 4.3 1.6 8.8 0.9 2.1 2 0 0 2 2 2 0 Phospholipid methyltransferase PhaG_MnhG_YufB PF03334.9 KOG97621.1 - 3.2 7.8 6.3 30 4.7 4.3 2.5 1 1 0 1 1 1 0 Na+/H+ antiporter subunit Amidase PF01425.16 KOG97622.1 - 5.7e-120 401.1 0.0 6.9e-120 400.8 0.0 1.0 1 0 0 1 1 1 1 Amidase Dynamitin PF04912.9 KOG97623.1 - 3.8e-09 35.8 23.8 2e-08 33.4 16.4 2.1 1 1 0 1 1 1 1 Dynamitin Med9 PF07544.8 KOG97623.1 - 0.0093 15.6 2.8 0.0093 15.6 1.9 3.5 3 1 1 4 4 4 1 RNA polymerase II transcription mediator complex subunit 9 DASH_Dam1 PF08653.5 KOG97623.1 - 0.43 10.3 2.5 13 5.6 0.0 3.4 3 0 0 3 3 3 0 DASH complex subunit Dam1 ApoO PF09769.4 KOG97623.1 - 0.49 10.0 3.8 0.39 10.4 0.5 2.2 2 0 0 2 2 2 0 Apolipoprotein O HSBP1 PF06825.7 KOG97623.1 - 0.54 9.8 8.7 0.067 12.7 1.6 3.0 3 0 0 3 3 3 0 Heat shock factor binding protein 1 SEA PF01390.15 KOG97623.1 - 2 8.1 6.9 0.67 9.6 0.1 3.0 4 0 0 4 4 4 0 SEA domain DUF948 PF06103.6 KOG97623.1 - 3.9 7.4 5.4 7.2 6.5 2.5 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FlaF PF07309.6 KOG97623.1 - 5.2 6.9 9.7 0.13 12.1 1.0 2.4 3 0 0 3 3 3 0 Flagellar protein FlaF Baculo_PEP_C PF04513.7 KOG97623.1 - 6.9 6.4 8.1 2.6 7.8 1.9 2.8 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2406 PF10295.4 KOG97624.1 - 3.4e-27 94.7 0.1 7.4e-27 93.6 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised protein (DUF2406) Aminotran_1_2 PF00155.16 KOG97625.1 - 6.2e-83 278.7 0.0 7.4e-83 278.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Peptidase_S10 PF00450.17 KOG97626.1 - 5.6e-129 430.9 0.3 7.3e-129 430.5 0.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.6 KOG97626.1 - 2.5e-29 101.6 0.0 4.3e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase Y pro-peptide DLIC PF05783.6 KOG97628.1 - 3.9e-06 25.8 0.1 5.7e-06 25.2 0.1 1.2 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) DNA_pol3_a_NII PF11490.3 KOG97628.1 - 0.056 13.0 1.5 0.099 12.2 0.8 1.6 1 1 0 1 1 1 0 DNA polymerase III polC-type N-terminus II GATase_2 PF00310.16 KOG97629.1 - 2e-24 85.9 0.2 1.9e-18 66.3 0.0 2.6 2 1 1 3 3 3 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 KOG97629.1 - 1.1e-14 54.5 0.0 3.7e-14 52.8 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase domain Pribosyltran PF00156.22 KOG97629.1 - 1.5e-12 47.3 0.0 2.8e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_7 PF13537.1 KOG97629.1 - 1.2e-11 44.4 0.0 2.3e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 KOG97629.1 - 6.1e-06 25.1 0.0 9.7e-06 24.4 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II PRTase_3 PF15610.1 KOG97629.1 - 0.063 12.1 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 PRTase ComF-like ABC_membrane PF00664.18 KOG97630.1 - 8.9e-39 133.5 13.1 1.1e-38 133.2 9.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 KOG97630.1 - 9.3e-36 123.1 0.0 1.9e-35 122.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOG97630.1 - 1.3e-08 35.2 0.4 0.00045 20.2 0.1 3.3 2 1 1 3 3 3 2 AAA domain SMC_N PF02463.14 KOG97630.1 - 7e-07 28.6 0.0 0.0016 17.7 0.0 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 KOG97630.1 - 0.00014 20.6 0.0 0.017 13.7 0.0 2.2 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_16 PF13191.1 KOG97630.1 - 0.00019 21.4 0.0 0.0014 18.6 0.0 2.3 2 1 1 3 3 2 1 AAA ATPase domain AAA_29 PF13555.1 KOG97630.1 - 0.00032 20.1 0.5 0.00078 18.9 0.3 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_17 PF13207.1 KOG97630.1 - 0.0037 18.0 0.1 0.01 16.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOG97630.1 - 0.0096 16.0 0.2 0.11 12.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 KOG97630.1 - 0.015 14.6 0.0 0.032 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 KOG97630.1 - 0.02 14.7 0.3 0.092 12.6 0.2 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.2 KOG97630.1 - 0.026 13.9 0.3 0.064 12.6 0.2 1.7 1 1 0 1 1 1 0 AAA-like domain Gtr1_RagA PF04670.7 KOG97630.1 - 0.059 12.4 0.0 0.11 11.5 0.0 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_23 PF13476.1 KOG97630.1 - 0.067 13.5 0.6 0.2 11.9 0.1 2.0 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 KOG97630.1 - 0.069 12.3 0.0 0.16 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 FtsK_SpoIIIE PF01580.13 KOG97630.1 - 0.074 12.5 0.1 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF87 PF01935.12 KOG97630.1 - 0.077 12.8 0.1 0.24 11.2 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function DUF87 RNA12 PF10443.4 KOG97631.1 - 2.9e-172 573.0 5.0 4.2e-171 569.2 1.5 2.2 2 0 0 2 2 2 2 RNA12 protein RRM_1 PF00076.17 KOG97631.1 - 4.5e-08 32.5 0.0 1.2e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_14 PF13173.1 KOG97631.1 - 0.00022 21.1 0.0 0.001 18.9 0.0 2.3 1 1 1 2 2 2 1 AAA domain Arch_ATPase PF01637.13 KOG97631.1 - 0.00045 20.0 4.6 0.0085 15.8 3.2 2.8 1 1 0 1 1 1 1 Archaeal ATPase RRN3 PF05327.6 KOG97631.1 - 0.0032 15.6 3.7 0.005 15.0 2.6 1.3 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 AAA_22 PF13401.1 KOG97631.1 - 0.049 13.7 0.0 0.6 10.2 0.0 2.6 2 1 0 2 2 2 0 AAA domain ADH_N PF08240.7 KOG97632.1 - 8.8e-31 105.8 0.3 2.9e-30 104.2 0.2 1.9 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOG97632.1 - 7.7e-30 103.1 1.4 1.1e-29 102.5 1.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KOG97632.1 - 1.5e-05 25.9 0.2 3.7e-05 24.6 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase UCH PF00443.24 KOG97633.1 - 2.3e-52 177.7 3.9 4e-52 176.9 2.7 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.1 KOG97633.1 - 1.8e-48 164.8 6.6 2.2e-47 161.2 2.0 3.5 3 1 0 3 3 3 1 Ubiquitin-specific protease C-terminal UCH_1 PF13423.1 KOG97633.1 - 2.4e-34 119.1 0.0 4.3e-34 118.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.3 KOG97633.1 - 6.3e-29 100.9 2.0 5e-25 88.1 0.0 3.8 4 1 0 4 4 4 2 ICP0-binding domain of Ubiquitin-specific protease 7 MATH PF00917.21 KOG97633.1 - 8.7e-15 55.0 0.1 3.9e-14 52.9 0.0 2.2 2 0 0 2 2 2 1 MATH domain UN_NPL4 PF11543.3 KOG97633.1 - 0.57 10.4 4.5 1.5 9.1 0.2 3.6 3 1 1 4 4 4 0 Nuclear pore localisation protein NPL4 Glyco_hydro_17 PF00332.13 KOG97634.1 - 7.4e-12 44.9 1.3 7.4e-12 44.9 0.9 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 DUF3337 PF11816.3 KOG97634.1 - 0.091 12.1 2.8 0.12 11.6 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) DUF2217 PF10265.4 KOG97634.1 - 0.56 8.9 5.8 0.68 8.6 4.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Macoilin PF09726.4 KOG97634.1 - 1.6 6.9 14.6 2.4 6.3 10.1 1.2 1 0 0 1 1 1 0 Transmembrane protein RAP1 PF07218.6 KOG97634.1 - 1.6 6.7 16.6 2.9 5.8 11.5 1.5 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Glucan_synthase PF02364.10 KOG97636.1 - 0 1405.8 0.3 0 1405.8 0.2 2.2 1 1 1 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 KOG97636.1 - 4.6e-40 136.1 0.5 1.5e-39 134.5 0.4 2.0 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Glyco_hydro_72 PF03198.9 KOG97637.1 - 3.7e-146 486.0 12.8 4.9e-146 485.6 8.9 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 KOG97637.1 - 6.2e-28 97.1 6.2 2.2e-27 95.3 4.3 2.0 1 0 0 1 1 1 1 X8 domain Ribosomal_L7Ae PF01248.21 KOG97637.1 - 0.06 12.8 0.1 0.17 11.4 0.1 1.7 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family HEAT_EZ PF13513.1 KOG97638.1 - 3.5e-19 68.6 14.1 1.8e-06 28.2 0.0 11.2 9 1 3 12 12 12 4 HEAT-like repeat HEAT_2 PF13646.1 KOG97638.1 - 1.2e-18 67.1 3.1 7.1e-08 32.6 0.0 6.9 7 1 1 8 8 8 4 HEAT repeats HEAT PF02985.17 KOG97638.1 - 2.6e-17 61.2 13.3 0.014 15.3 0.0 10.5 12 0 0 12 12 12 5 HEAT repeat CLASP_N PF12348.3 KOG97638.1 - 3e-08 33.2 1.0 0.0007 19.0 0.3 4.2 4 0 0 4 4 4 2 CLASP N terminal MMS19_C PF12460.3 KOG97638.1 - 3.2e-07 29.4 9.8 0.0014 17.4 0.4 4.2 5 0 0 5 5 5 2 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.2 KOG97638.1 - 1.5e-06 28.4 0.3 0.69 10.3 0.0 6.9 4 2 3 8 8 8 1 Vacuolar 14 Fab1-binding region DNA_alkylation PF08713.6 KOG97638.1 - 0.015 14.7 0.0 0.057 12.9 0.0 2.1 1 0 0 1 1 1 0 DNA alkylation repair enzyme Arm PF00514.18 KOG97638.1 - 0.038 13.8 12.6 2.2 8.2 0.0 6.5 8 0 0 8 8 8 0 Armadillo/beta-catenin-like repeat eIF-3c_N PF05470.7 KOG97639.1 - 5.2e-195 649.0 28.7 1.5e-152 508.7 6.2 2.6 2 1 1 3 3 3 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.22 KOG97639.1 - 3.5e-12 46.5 0.3 3.5e-12 46.5 0.2 3.2 3 2 0 3 3 3 1 PCI domain Methyltrn_RNA_3 PF02598.12 KOG97640.1 - 4.8e-83 278.8 0.1 5.6e-83 278.6 0.1 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase IPP-2 PF04979.9 KOG97641.1 - 2.1e-06 27.9 12.2 2.1e-06 27.9 8.5 2.0 2 1 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) DUF3135 PF11333.3 KOG97641.1 - 0.1 12.7 0.2 0.1 12.7 0.1 2.4 3 1 0 3 3 3 0 Protein of unknown function (DUF3135) DUF2348 PF09807.4 KOG97642.1 - 0.0033 16.5 0.0 0.0067 15.5 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2348) RasGEF_N PF00618.15 KOG97642.1 - 0.1 12.7 2.2 0.16 12.0 0.8 1.9 1 1 1 2 2 2 0 RasGEF N-terminal motif DUF3336 PF11815.3 KOG97643.1 - 8.7e-28 96.6 0.1 1.7e-27 95.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 KOG97643.1 - 2.8e-08 33.9 0.0 5.7e-08 32.9 0.0 1.7 1 1 0 1 1 1 1 Patatin-like phospholipase DUF3446 PF11928.3 KOG97643.1 - 4 7.7 6.4 9.4 6.5 4.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) Proteasome PF00227.21 KOG97644.1 - 9.5e-45 152.2 0.0 1.2e-44 151.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KOG97644.1 - 9e-13 47.2 0.2 1.9e-12 46.2 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Flg_hook PF02120.11 KOG97644.1 - 0.14 11.8 0.3 9.9 5.9 0.0 2.4 2 0 0 2 2 2 0 Flagellar hook-length control protein FliK GFO_IDH_MocA PF01408.17 KOG97645.1 - 3.1e-25 89.0 0.1 7.6e-24 84.5 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 KOG97645.1 - 7.4e-11 41.8 0.0 1.2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.11 KOG97645.1 - 0.019 15.3 0.0 0.036 14.4 0.0 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain ADH_N PF08240.7 KOG97649.1 - 1.8e-28 98.4 5.2 3.1e-28 97.6 3.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOG97649.1 - 9.1e-18 64.0 0.0 1.4e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 KOG97649.1 - 4.7e-06 25.8 0.1 8.7e-06 25.0 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.1 KOG97649.1 - 1.2e-05 26.2 0.0 2e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_7 PF13241.1 KOG97649.1 - 0.037 14.2 0.0 0.084 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_2 PF03446.10 KOG97649.1 - 0.077 12.8 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Iron_permease PF04120.7 KOG97650.1 - 6.2e-29 100.2 20.6 2.8e-16 59.3 0.4 5.0 5 0 0 5 5 5 4 Low affinity iron permease S-methyl_trans PF02574.11 KOG97651.1 - 5.3e-50 170.4 0.0 5.8e-50 170.3 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase AA_permease PF00324.16 KOG97652.1 - 5.2e-96 321.8 36.1 5.9e-96 321.6 25.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG97652.1 - 2.1e-34 118.7 37.5 2.6e-34 118.5 26.0 1.0 1 0 0 1 1 1 1 Amino acid permease TrbC PF04956.8 KOG97652.1 - 6.6 6.8 16.8 1.3 9.1 0.1 4.3 4 1 0 4 4 4 0 TrbC/VIRB2 family AA_permease PF00324.16 KOG97653.1 - 2.8e-89 299.6 38.5 3.5e-89 299.3 26.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG97653.1 - 6.2e-22 77.7 42.6 9.6e-22 77.0 29.4 1.3 1 1 0 1 1 1 1 Amino acid permease Sugar_tr PF00083.19 KOG97654.1 - 2.6e-44 151.5 8.5 3e-44 151.3 5.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG97654.1 - 5.2e-14 51.7 6.4 5.2e-14 51.7 4.4 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 KOG97654.1 - 4.3e-05 21.9 1.5 6.2e-05 21.3 1.0 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ATG22 PF11700.3 KOG97654.1 - 8.2e-05 21.2 3.1 0.00011 20.8 2.1 1.1 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_2 PF13347.1 KOG97654.1 - 0.00026 19.5 1.8 0.00038 18.9 1.3 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein DUF1275 PF06912.6 KOG97654.1 - 0.012 14.8 1.4 0.019 14.1 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1275) DUF1469 PF07332.6 KOG97654.1 - 0.16 11.7 2.8 0.25 11.0 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) SNO PF01174.14 KOG97655.1 - 1.9e-12 47.2 0.1 2.1e-12 47.0 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family Sugar_tr PF00083.19 KOG97656.1 - 3.2e-121 405.0 22.2 3.7e-121 404.8 15.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG97656.1 - 1.5e-26 92.9 32.7 6.8e-24 84.2 8.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Flavoprotein PF02441.14 KOG97657.1 - 7.6e-25 87.0 0.7 1.1e-24 86.5 0.5 1.1 1 0 0 1 1 1 1 Flavoprotein UbiD PF01977.11 KOG97658.1 - 2e-126 421.7 0.0 2.2e-126 421.5 0.0 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2-Hacid_dh_C PF02826.14 KOG97659.1 - 3.9e-40 136.8 0.0 1.5e-39 134.9 0.0 1.9 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 KOG97659.1 - 6.4e-19 67.7 0.1 9.4e-19 67.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 KOG97659.1 - 0.0016 18.3 0.1 0.0073 16.1 0.0 2.1 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.15 KOG97659.1 - 0.081 13.0 0.2 2 8.4 0.0 2.8 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Helicase_C PF00271.26 KOG97662.1 - 2e-09 37.1 0.0 3.1e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain THP2 PF09432.5 KOG97662.1 - 0.033 14.0 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 Tho complex subunit THP2 DUF1469 PF07332.6 KOG97663.1 - 6.9 6.4 14.5 0.75 9.5 6.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) DUF3099 PF11298.3 KOG97663.1 - 8.2 6.2 8.6 8.9 6.1 0.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3099) Cys_Met_Meta_PP PF01053.15 KOG97664.1 - 1.5e-29 102.4 0.0 3.7e-29 101.2 0.0 1.6 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 KOG97664.1 - 0.0017 17.3 0.0 0.0031 16.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOG97664.1 - 0.11 11.5 0.0 0.27 10.3 0.0 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase MFS_1 PF07690.11 KOG97665.1 - 4.8e-18 64.9 48.8 6.7e-18 64.5 30.6 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Zn_clus PF00172.13 KOG97666.1 - 2.7e-08 33.5 17.2 2.7e-08 33.5 11.9 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 KOG97667.1 - 1.1e-38 132.8 59.0 4.7e-35 120.9 28.1 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily IncA PF04156.9 KOG97667.1 - 0.012 15.2 0.0 0.012 15.2 0.0 3.2 4 1 0 4 4 4 0 IncA protein ACT PF01842.20 KOG97667.1 - 0.11 11.9 0.3 0.32 10.5 0.1 1.9 2 0 0 2 2 2 0 ACT domain DUF3784 PF12650.2 KOG97667.1 - 1 9.3 16.1 4 7.4 0.5 4.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3784) TauD PF02668.11 KOG97668.1 - 1.4e-50 172.4 0.7 1.9e-50 171.9 0.5 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family NAD_binding_10 PF13460.1 KOG97669.1 - 1.9e-13 50.8 0.0 2.4e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOG97669.1 - 4.1e-13 49.3 0.1 3.6e-12 46.2 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KOG97669.1 - 1.2e-09 37.2 0.2 9.8e-09 34.3 0.1 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 KOG97669.1 - 4.7e-06 25.7 0.0 4.4e-05 22.5 0.0 2.0 1 1 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.8 KOG97669.1 - 8.1e-06 25.2 0.1 1.4e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.20 KOG97669.1 - 0.00042 20.2 0.1 0.00069 19.5 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.7 KOG97669.1 - 0.0016 17.4 0.1 0.0067 15.3 0.1 1.9 1 1 0 1 1 1 1 Male sterility protein DapB_N PF01113.15 KOG97669.1 - 0.014 15.3 0.5 0.055 13.3 0.1 2.1 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus TrkA_N PF02254.13 KOG97669.1 - 0.037 14.0 0.1 0.064 13.2 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Flocculin_t3 PF13928.1 KOG97670.1 - 1.7e-21 76.0 46.7 9e-13 48.1 12.7 7.7 6 2 1 7 7 7 2 Flocculin type 3 repeat Zn_clus PF00172.13 KOG97671.1 - 3.3e-08 33.3 8.6 5.8e-08 32.5 6.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MIP PF00230.15 KOG97672.1 - 9.9e-44 149.4 14.1 1.2e-43 149.1 9.8 1.1 1 0 0 1 1 1 1 Major intrinsic protein FAD_binding_8 PF08022.7 KOG97673.1 - 1.7e-26 92.1 0.0 4.9e-26 90.6 0.0 1.8 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 KOG97673.1 - 2.8e-21 76.0 0.0 5.2e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 KOG97673.1 - 1.6e-20 73.4 14.6 2.7e-20 72.7 7.5 2.6 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.16 KOG97673.1 - 0.042 14.4 0.0 2.8 8.5 0.0 2.4 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain DUF3262 PF11660.3 KOG97673.1 - 0.097 12.7 6.2 0.2 11.7 1.6 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3262) Cofilin_ADF PF00241.15 KOG97674.1 - 6.9e-10 38.9 0.1 7.4e-10 38.8 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein AKNA PF12443.3 KOG97675.1 - 0.074 13.0 0.2 0.16 11.9 0.1 1.7 2 0 0 2 2 2 0 AT-hook-containing transcription factor DUF2408 PF10303.4 KOG97675.1 - 0.35 10.9 2.2 17 5.5 0.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF2408) ABC_tran PF00005.22 KOG97676.1 - 3.1e-56 189.4 0.9 7.5e-34 116.9 0.1 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 KOG97676.1 - 3.1e-54 184.2 37.4 1.9e-31 109.5 6.4 3.7 4 0 0 4 4 3 3 ABC transporter transmembrane region AAA_23 PF13476.1 KOG97676.1 - 1.3e-10 41.9 10.8 2.2e-06 28.1 0.0 3.4 4 0 0 4 4 2 2 AAA domain SMC_N PF02463.14 KOG97676.1 - 2.9e-09 36.4 8.4 0.00011 21.4 2.3 3.9 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 KOG97676.1 - 3.6e-08 32.8 0.5 0.0012 18.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.1 KOG97676.1 - 7.1e-08 32.7 19.8 1.8e-06 28.1 0.3 5.1 4 2 0 4 4 2 2 AAA domain MMR_HSR1 PF01926.18 KOG97676.1 - 2.9e-06 27.2 0.1 0.016 15.1 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF258 PF03193.11 KOG97676.1 - 3e-06 26.5 0.0 0.046 12.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 T2SE PF00437.15 KOG97676.1 - 3.5e-06 26.1 0.0 0.0086 15.0 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_22 PF13401.1 KOG97676.1 - 7.5e-06 26.1 0.1 0.12 12.4 0.0 3.3 2 1 0 2 2 2 2 AAA domain Miro PF08477.8 KOG97676.1 - 1.1e-05 25.8 0.0 0.37 11.2 0.0 3.1 2 0 0 2 2 2 2 Miro-like protein AAA_17 PF13207.1 KOG97676.1 - 2e-05 25.4 0.0 0.24 12.2 0.0 3.5 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.1 KOG97676.1 - 2.2e-05 24.5 0.3 0.13 12.2 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain ATP_bind_1 PF03029.12 KOG97676.1 - 5e-05 22.9 0.0 1.4 8.3 0.0 3.4 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein DUF87 PF01935.12 KOG97676.1 - 7.2e-05 22.7 2.4 0.34 10.7 0.3 3.0 2 1 0 2 2 2 2 Domain of unknown function DUF87 AAA_10 PF12846.2 KOG97676.1 - 0.00011 21.7 0.4 0.0093 15.4 0.0 2.9 3 0 0 3 3 3 1 AAA-like domain Dynamin_N PF00350.18 KOG97676.1 - 0.00015 21.6 0.3 0.068 12.9 0.1 2.8 2 0 0 2 2 2 1 Dynamin family MobB PF03205.9 KOG97676.1 - 0.00033 20.3 0.0 1 9.0 0.0 2.6 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 KOG97676.1 - 0.00035 19.7 0.0 0.67 9.0 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin AAA_25 PF13481.1 KOG97676.1 - 0.00043 19.7 0.0 0.21 10.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 KOG97676.1 - 0.00065 19.5 0.7 1.4 8.6 0.0 3.7 4 0 0 4 4 3 1 Type III restriction enzyme, res subunit FtsK_SpoIIIE PF01580.13 KOG97676.1 - 0.0018 17.7 0.0 1.7 8.0 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_18 PF13238.1 KOG97676.1 - 0.002 18.4 0.0 2.3 8.5 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 KOG97676.1 - 0.0022 18.2 0.2 2.7 8.1 0.0 3.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 KOG97676.1 - 0.0038 17.0 0.0 1.3 8.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOG97676.1 - 0.0046 16.6 0.2 0.19 11.5 0.0 3.1 3 0 0 3 3 3 1 Part of AAA domain AAA_30 PF13604.1 KOG97676.1 - 0.0058 16.2 0.4 4.6 6.7 0.0 2.8 2 1 0 2 2 2 0 AAA domain ArgK PF03308.11 KOG97676.1 - 0.0073 15.1 0.1 0.2 10.4 0.0 2.2 2 0 0 2 2 2 1 ArgK protein TrwB_AAD_bind PF10412.4 KOG97676.1 - 0.02 13.5 0.0 3.2 6.2 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.14 KOG97676.1 - 0.044 13.2 3.7 2 7.8 0.3 3.1 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.1 KOG97676.1 - 0.045 13.3 0.5 9.2 5.7 0.1 2.6 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 KOG97676.1 - 0.068 12.5 0.0 4.5 6.6 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein PhoH PF02562.11 KOG97676.1 - 0.16 11.2 0.9 1.2 8.2 0.0 2.7 3 0 0 3 3 3 0 PhoH-like protein Ribosomal_L7Ae PF01248.21 KOG97677.1 - 1.9e-22 78.5 0.3 3e-22 77.9 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 KOG97677.1 - 0.00061 19.6 0.1 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 RNase P subunit Pop3 MIP PF00230.15 KOG97678.1 - 7.8e-84 280.6 8.6 1e-83 280.2 5.9 1.2 1 0 0 1 1 1 1 Major intrinsic protein ANT PF03374.9 KOG97678.1 - 0.14 12.2 0.0 4.1 7.4 0.0 2.5 2 0 0 2 2 2 0 Phage antirepressor protein KilAC domain Autophagy_act_C PF03987.10 KOG97679.1 - 1.9e-08 34.3 0.0 4.7e-08 33.0 0.0 1.7 1 1 0 1 1 1 1 Autophagocytosis associated protein, active-site domain AAA_35 PF14516.1 KOG97679.1 - 0.048 12.3 0.2 0.076 11.6 0.1 1.3 1 1 0 1 1 1 0 AAA-like domain Fer2_3 PF13085.1 KOG97680.1 - 3.7e-33 113.6 0.1 6.7e-33 112.7 0.1 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.1 KOG97680.1 - 5.8e-10 39.3 8.1 5.8e-10 39.3 5.6 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.1 KOG97680.1 - 7.5e-09 35.5 6.1 7.5e-09 35.5 4.3 2.0 2 1 1 3 3 3 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 KOG97680.1 - 1.1e-05 25.6 3.1 1.1e-05 25.6 2.2 2.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.1 KOG97680.1 - 0.00023 20.8 5.8 0.00023 20.8 4.0 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.22 KOG97680.1 - 0.0038 16.9 5.2 0.005 16.5 1.2 2.4 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.2 KOG97680.1 - 0.0049 17.2 6.6 0.0049 17.2 4.6 2.6 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 KOG97680.1 - 0.011 15.9 12.5 0.99 9.7 0.0 3.1 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_15 PF13459.1 KOG97680.1 - 5.5 7.6 8.3 1.5 9.4 0.1 2.7 3 0 0 3 3 3 0 4Fe-4S single cluster domain DUF1162 PF06650.7 KOG97681.1 - 3.1e-84 282.4 11.3 2.9e-81 272.7 2.9 3.0 2 0 0 2 2 2 2 Protein of unknown function (DUF1162) Chorein_N PF12624.2 KOG97681.1 - 2.9e-40 136.4 1.5 5.7e-40 135.5 0.0 2.4 2 0 0 2 2 2 1 N-terminal region of Chorein, a TM vesicle-mediated sorter ENTH PF01417.15 KOG97682.1 - 5.6e-36 123.1 1.3 7.8e-36 122.6 0.9 1.2 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 KOG97682.1 - 5.4e-05 22.0 0.1 8.2e-05 21.4 0.1 1.3 1 0 0 1 1 1 1 ANTH domain VHS PF00790.14 KOG97682.1 - 0.017 14.7 0.1 0.028 14.0 0.1 1.4 1 0 0 1 1 1 0 VHS domain Rbsn PF11464.3 KOG97682.1 - 0.068 12.7 2.1 0.17 11.4 1.5 1.7 1 0 0 1 1 1 0 Rabenosyn Rab binding domain RasGAP_C PF03836.10 KOG97682.1 - 0.27 10.9 3.6 0.37 10.4 2.3 1.5 1 1 0 1 1 1 0 RasGAP C-terminus Stm1_N PF09598.5 KOG97682.1 - 0.32 11.7 2.4 0.49 11.1 0.2 2.3 2 0 0 2 2 2 0 Stm1 Prp19 PF08606.6 KOG97683.1 - 1.1e-25 89.0 0.3 2.4e-25 88.0 0.2 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like U-box PF04564.10 KOG97683.1 - 0.00021 21.1 0.0 0.00058 19.7 0.0 1.8 1 0 0 1 1 1 1 U-box domain DUF3836 PF12930.2 KOG97683.1 - 6.3 6.3 7.6 2.3 7.7 0.2 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF3836) Clp1 PF06807.9 KOG97684.1 - 2.9e-06 27.2 0.0 5.5e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 MMR_HSR1 PF01926.18 KOG97684.1 - 0.0056 16.6 0.0 0.014 15.3 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase MobB PF03205.9 KOG97684.1 - 0.007 16.0 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.13 KOG97684.1 - 0.017 14.5 0.0 0.031 13.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Miro PF08477.8 KOG97684.1 - 0.02 15.4 0.0 0.056 13.9 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein AAA_14 PF13173.1 KOG97684.1 - 0.025 14.5 0.0 0.098 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain VirE PF05272.6 KOG97684.1 - 0.035 13.5 0.0 0.075 12.5 0.0 1.5 1 0 0 1 1 1 0 Virulence-associated protein E AAA PF00004.24 KOG97685.1 - 1.4e-94 313.2 0.0 1.8e-47 160.8 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOG97685.1 - 7.2e-16 57.9 0.0 7.1e-09 35.0 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 KOG97685.1 - 6.8e-12 46.2 0.1 1.2e-06 29.3 0.0 3.4 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.1 KOG97685.1 - 1.6e-11 44.5 2.4 0.0004 20.4 0.1 3.9 3 2 1 4 4 3 2 AAA ATPase domain AAA_2 PF07724.9 KOG97685.1 - 2.8e-11 43.6 0.0 0.00022 21.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 KOG97685.1 - 3e-11 43.5 0.3 0.0032 17.6 0.0 4.9 3 2 0 3 3 3 2 AAA domain AAA_33 PF13671.1 KOG97685.1 - 2.8e-10 40.2 0.0 0.00025 20.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.1 KOG97685.1 - 3.7e-10 39.7 0.0 0.00092 19.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 KOG97685.1 - 6.1e-10 38.5 0.0 0.0011 18.1 0.0 2.6 3 0 0 3 3 2 2 Zeta toxin AAA_5 PF07728.9 KOG97685.1 - 1.2e-09 38.0 0.8 0.0023 17.6 0.0 3.9 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 KOG97685.1 - 7.5e-09 35.9 0.5 0.00016 21.9 0.0 3.4 3 0 0 3 3 3 2 AAA domain TIP49 PF06068.8 KOG97685.1 - 1.7e-08 33.6 0.0 0.00028 19.7 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus RNA_helicase PF00910.17 KOG97685.1 - 1.2e-07 31.8 0.0 0.015 15.4 0.0 3.2 3 0 0 3 3 2 2 RNA helicase ABC_tran PF00005.22 KOG97685.1 - 2.7e-07 30.9 0.1 0.015 15.5 0.0 3.2 3 0 0 3 3 2 2 ABC transporter AAA_25 PF13481.1 KOG97685.1 - 7.7e-07 28.7 3.1 0.65 9.3 0.1 4.6 2 2 1 4 4 4 2 AAA domain Vps4_C PF09336.5 KOG97685.1 - 8.7e-07 28.7 0.1 0.00035 20.4 0.0 2.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.12 KOG97685.1 - 1.3e-06 27.9 0.3 0.04 13.3 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_19 PF13245.1 KOG97685.1 - 2.1e-06 27.3 1.6 0.061 13.0 0.1 2.7 2 0 0 2 2 2 2 Part of AAA domain AAA_28 PF13521.1 KOG97685.1 - 2.1e-06 27.7 0.0 0.041 13.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 KOG97685.1 - 2.7e-06 26.7 0.4 0.027 13.6 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Cytidylate_kin2 PF13189.1 KOG97685.1 - 9.5e-06 25.6 0.0 0.0011 18.9 0.0 2.9 3 0 0 3 3 2 1 Cytidylate kinase-like family SKI PF01202.17 KOG97685.1 - 1.1e-05 25.4 0.0 0.073 12.9 0.0 2.8 2 0 0 2 2 2 2 Shikimate kinase AAA_3 PF07726.6 KOG97685.1 - 1.4e-05 24.7 0.0 0.076 12.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 KOG97685.1 - 2.1e-05 24.2 0.3 0.43 10.2 0.0 3.4 4 0 0 4 4 3 2 NACHT domain Rad17 PF03215.10 KOG97685.1 - 2.1e-05 23.3 0.0 0.086 11.5 0.0 3.2 3 0 0 3 3 3 1 Rad17 cell cycle checkpoint protein Viral_helicase1 PF01443.13 KOG97685.1 - 0.00018 21.0 0.0 0.51 9.8 0.0 2.5 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Arch_ATPase PF01637.13 KOG97685.1 - 0.00025 20.8 0.0 2.4 7.8 0.0 3.6 2 2 1 3 3 3 2 Archaeal ATPase Sigma54_activ_2 PF14532.1 KOG97685.1 - 0.00028 20.9 0.0 0.64 10.0 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain NB-ARC PF00931.17 KOG97685.1 - 0.00035 19.5 0.0 0.31 9.8 0.0 2.9 3 0 0 3 3 2 1 NB-ARC domain DUF815 PF05673.8 KOG97685.1 - 0.00058 18.8 0.0 0.23 10.3 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 KOG97685.1 - 0.00084 18.8 0.0 0.74 9.2 0.0 3.0 2 1 1 3 3 3 1 Sigma-54 interaction domain AAA_11 PF13086.1 KOG97685.1 - 0.001 18.7 0.7 0.74 9.3 0.0 3.3 3 0 0 3 3 3 1 AAA domain CPT PF07931.7 KOG97685.1 - 0.0014 18.2 0.0 0.03 13.9 0.0 2.3 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein Parvo_NS1 PF01057.12 KOG97685.1 - 0.0018 17.1 0.0 1.4 7.7 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 SRPRB PF09439.5 KOG97685.1 - 0.0026 17.0 0.0 0.92 8.7 0.0 3.1 3 0 0 3 3 2 1 Signal recognition particle receptor beta subunit KaiC PF06745.8 KOG97685.1 - 0.0028 16.8 0.1 2.8 7.0 0.0 3.2 3 0 0 3 3 3 1 KaiC AAA_24 PF13479.1 KOG97685.1 - 0.0028 17.2 0.1 3.1 7.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 KOG97685.1 - 0.0033 16.9 0.0 1 8.8 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain PhoH PF02562.11 KOG97685.1 - 0.0065 15.7 0.1 1.8 7.7 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein Miro PF08477.8 KOG97685.1 - 0.012 16.0 0.7 11 6.5 0.0 4.2 4 1 1 5 5 3 0 Miro-like protein NTPase_1 PF03266.10 KOG97685.1 - 0.015 15.0 0.0 4.1 7.0 0.0 2.5 2 0 0 2 2 2 0 NTPase UPF0079 PF02367.12 KOG97685.1 - 0.015 14.8 0.0 5 6.7 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 PduV-EutP PF10662.4 KOG97685.1 - 0.02 14.4 0.0 6.9 6.1 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.18 KOG97685.1 - 0.044 13.7 0.1 3.5 7.6 0.0 3.0 2 1 1 3 3 2 0 50S ribosome-binding GTPase DUF258 PF03193.11 KOG97685.1 - 0.066 12.3 0.6 0.9 8.7 0.0 2.7 3 0 0 3 3 2 0 Protein of unknown function, DUF258 ADK PF00406.17 KOG97685.1 - 0.096 12.5 0.9 21 4.9 0.0 3.3 3 0 0 3 3 3 0 Adenylate kinase FeoB_N PF02421.13 KOG97685.1 - 0.1 11.8 0.1 3 7.1 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B NifW PF03206.9 KOG97685.1 - 0.1 12.6 0.0 0.34 11.0 0.0 1.8 1 0 0 1 1 1 0 Nitrogen fixation protein NifW AAA_29 PF13555.1 KOG97685.1 - 0.11 12.0 0.0 6.3 6.4 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain KH_1 PF00013.24 KOG97687.1 - 2.5e-09 36.6 0.4 0.00011 21.7 0.0 4.2 4 0 0 4 4 4 3 KH domain KH_3 PF13014.1 KOG97687.1 - 0.0018 17.8 6.6 0.018 14.6 0.0 4.0 4 0 0 4 4 4 1 KH domain Phosphodiest PF01663.17 KOG97688.1 - 4.5e-13 49.2 1.3 8.5e-13 48.3 0.9 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 KOG97688.1 - 0.0012 18.3 2.4 0.0027 17.1 1.7 1.5 1 0 0 1 1 1 1 Metalloenzyme superfamily Peptidase_M24 PF00557.19 KOG97689.1 - 1.1e-37 129.5 0.0 1e-36 126.4 0.0 2.1 2 0 0 2 2 2 1 Metallopeptidase family M24 Creatinase_N PF01321.13 KOG97689.1 - 1.9e-12 47.8 0.0 1.7e-11 44.7 0.0 2.2 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain DUF367 PF04034.8 KOG97689.1 - 0.0066 16.0 0.1 0.014 15.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF367) MFS_1 PF07690.11 KOG97690.1 - 2.5e-40 138.2 31.7 2.5e-40 138.2 22.0 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOG97690.1 - 4.2e-05 22.3 33.3 4.2e-05 22.3 23.1 3.4 1 1 1 2 2 2 2 Sugar (and other) transporter Fe-S_biosyn PF01521.15 KOG97691.1 - 1.1e-18 67.2 0.0 2e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF3853 PF12964.2 KOG97691.1 - 0.045 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3853) AAA_2 PF07724.9 KOG97692.1 - 5.2e-47 159.9 0.0 4.4e-45 153.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 KOG97692.1 - 3.2e-24 85.6 0.2 1.3e-14 54.5 0.1 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 KOG97692.1 - 3.2e-23 81.4 1.4 1.3e-22 79.5 1.0 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 KOG97692.1 - 2.3e-15 56.5 0.1 1.9e-07 30.9 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.15 KOG97692.1 - 9e-15 54.3 4.4 1.4e-09 37.7 0.3 3.4 3 0 0 3 3 3 2 Clp amino terminal domain Sigma54_activat PF00158.21 KOG97692.1 - 1.4e-12 47.3 0.1 2.6e-08 33.5 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.1 KOG97692.1 - 4.7e-11 43.0 5.1 0.00025 21.1 0.0 4.6 4 2 1 5 5 4 2 AAA ATPase domain AAA_22 PF13401.1 KOG97692.1 - 2.1e-08 34.3 0.2 0.0063 16.6 0.1 3.6 3 1 0 3 3 2 2 AAA domain Mg_chelatase PF01078.16 KOG97692.1 - 0.00057 19.1 0.0 1.7 7.7 0.0 3.5 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 KOG97692.1 - 0.00086 18.4 0.2 0.13 11.3 0.0 3.4 3 0 0 3 3 3 1 Zeta toxin AAA_19 PF13245.1 KOG97692.1 - 0.0014 18.3 0.0 0.7 9.6 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_33 PF13671.1 KOG97692.1 - 0.0019 18.1 0.1 0.16 11.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain Arch_ATPase PF01637.13 KOG97692.1 - 0.002 17.8 5.8 0.43 10.2 0.6 4.4 3 1 0 3 3 3 1 Archaeal ATPase AAA_3 PF07726.6 KOG97692.1 - 0.002 17.7 0.1 0.68 9.5 0.0 3.2 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Torsin PF06309.6 KOG97692.1 - 0.0035 17.2 0.0 0.014 15.2 0.0 2.0 2 0 0 2 2 1 1 Torsin NACHT PF05729.7 KOG97692.1 - 0.0036 16.9 0.0 1.3 8.6 0.0 2.9 2 0 0 2 2 2 1 NACHT domain AAA_17 PF13207.1 KOG97692.1 - 0.0042 17.8 7.6 0.27 12.0 0.0 4.3 4 1 0 4 4 3 1 AAA domain IstB_IS21 PF01695.12 KOG97692.1 - 0.0075 15.7 0.0 0.47 9.8 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein NTPase_1 PF03266.10 KOG97692.1 - 0.037 13.7 0.0 3.8 7.1 0.0 3.4 3 0 0 3 3 3 0 NTPase PEPCK_ATP PF01293.15 KOG97692.1 - 0.046 12.2 0.0 0.12 10.8 0.0 1.6 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase MobB PF03205.9 KOG97692.1 - 0.073 12.7 0.0 8.3 6.1 0.0 2.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Viral_helicase1 PF01443.13 KOG97692.1 - 0.073 12.5 0.0 9.1 5.7 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.1 KOG97692.1 - 2.2 8.6 8.2 6.2 7.1 0.0 4.0 4 1 0 4 4 3 0 AAA domain DUF4337 PF14235.1 KOG97692.1 - 3.5 7.4 8.1 11 5.7 5.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) ABC_tran PF00005.22 KOG97692.1 - 4.7 7.5 8.5 5.8 7.2 0.1 4.0 4 1 0 4 4 3 0 ABC transporter SRP1_TIP1 PF00660.12 KOG97693.1 - 8.6e-33 112.2 0.1 1.1e-32 111.8 0.1 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family DUF2613 PF11021.3 KOG97693.1 - 0.0094 15.6 3.6 0.022 14.4 2.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2613) HSP70 PF00012.15 KOG97694.1 - 4.9e-274 909.8 8.2 5.6e-274 909.6 5.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOG97694.1 - 1.3e-17 63.4 0.0 1.3e-16 60.1 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 KOG97694.1 - 0.0016 18.1 0.0 0.0046 16.6 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.5 KOG97694.1 - 0.002 17.0 0.5 0.042 12.6 0.1 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain BcrAD_BadFG PF01869.15 KOG97694.1 - 0.034 13.4 0.0 3.9 6.6 0.0 2.6 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.13 KOG97694.1 - 0.082 11.9 1.3 0.37 9.8 0.0 2.5 2 1 1 3 3 3 0 Hydantoinase/oxoprolinase Surf_Ag_VNR PF07244.10 KOG97694.1 - 0.29 11.5 2.8 30 5.1 0.5 3.3 3 0 0 3 3 3 0 Surface antigen variable number repeat UPF0121 PF03661.8 KOG97695.1 - 1.1e-11 44.3 11.4 2.5e-11 43.2 7.9 1.6 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0121) Hum_adeno_E3A PF05393.6 KOG97695.1 - 0.00045 19.8 1.0 0.0051 16.4 0.4 2.3 2 0 0 2 2 2 1 Human adenovirus early E3A glycoprotein PhaG_MnhG_YufB PF03334.9 KOG97695.1 - 0.026 14.5 3.6 0.98 9.5 0.3 2.9 2 1 0 2 2 2 0 Na+/H+ antiporter subunit TPR_11 PF13414.1 KOG97696.1 - 3.4e-08 32.9 0.5 0.00034 20.1 0.0 2.7 2 1 0 2 2 2 2 TPR repeat TPR_16 PF13432.1 KOG97696.1 - 6.4e-06 26.6 3.4 0.46 11.2 0.1 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOG97696.1 - 5.2e-05 23.5 4.0 4.3 8.2 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOG97696.1 - 0.0012 18.5 10.1 1.4 9.0 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOG97696.1 - 0.0025 17.4 1.2 4.5 7.3 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 KOG97696.1 - 0.0026 16.9 0.1 0.01 15.0 0.0 2.2 2 0 0 2 2 2 1 SHNi-TPR TPR_12 PF13424.1 KOG97696.1 - 0.0026 17.6 9.8 0.0072 16.2 0.6 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat Amino_oxidase PF01593.19 KOG97696.1 - 0.0088 15.1 0.3 0.021 13.8 0.0 1.6 1 1 1 2 2 2 1 Flavin containing amine oxidoreductase Sec31 PF11549.3 KOG97696.1 - 0.0089 15.6 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 Protein transport protein SEC31 TPR_1 PF00515.23 KOG97696.1 - 0.015 14.8 7.4 1.3 8.7 0.0 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOG97696.1 - 0.098 12.4 0.1 0.098 12.4 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 KOG97696.1 - 0.74 9.7 5.2 9.2 6.2 0.0 3.9 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_19 PF14559.1 KOG97696.1 - 2.6 8.4 13.5 2.4 8.5 0.1 4.2 4 1 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.20 KOG97697.1 - 3.9e-49 167.1 0.3 1.9e-48 164.8 0.2 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97697.1 - 4.1e-17 62.1 0.0 8.9e-17 61.0 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase CHCH PF06747.8 KOG97698.1 - 0.00029 20.6 12.7 0.0012 18.7 3.6 1.8 1 1 1 2 2 2 2 CHCH domain Pet191_N PF10203.4 KOG97698.1 - 0.0098 15.9 1.9 0.017 15.1 1.3 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 tRNA-synt_2 PF00152.15 KOG97699.1 - 7.6e-80 268.1 0.3 1.3e-79 267.4 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KOG97699.1 - 8.9e-07 28.6 0.1 1.8e-06 27.6 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 KOG97699.1 - 0.0085 15.3 0.5 1.2 8.2 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Toprim_C_rpt PF13368.1 KOG97699.1 - 1.4 9.4 6.3 7 7.2 0.0 2.7 2 0 0 2 2 2 0 Topoisomerase C-terminal repeat RasGEF PF00617.14 KOG97700.1 - 2.1e-59 200.3 2.9 2.8e-59 199.9 0.6 2.3 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 KOG97700.1 - 2.1e-15 56.7 5.0 2.5e-14 53.2 0.2 3.9 3 0 0 3 3 3 1 RasGEF N-terminal motif SH3_1 PF00018.23 KOG97700.1 - 1.5e-05 24.2 0.0 4.7e-05 22.6 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOG97700.1 - 5.3e-05 22.7 0.1 0.00013 21.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOG97700.1 - 0.0061 16.0 0.0 0.015 14.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain ABC_membrane PF00664.18 KOG97701.1 - 2.9e-62 210.5 44.7 1.1e-36 126.7 6.1 2.6 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.22 KOG97701.1 - 1.7e-49 167.6 0.0 1.8e-29 102.7 0.1 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 KOG97701.1 - 7.3e-09 35.1 9.4 0.0018 17.5 1.9 3.9 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 KOG97701.1 - 1.1e-06 28.1 0.0 0.056 12.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 KOG97701.1 - 4.3e-06 26.6 0.2 0.14 12.1 0.0 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_10 PF12846.2 KOG97701.1 - 5.8e-06 25.9 0.4 0.025 14.0 0.0 2.7 2 1 0 2 2 2 2 AAA-like domain AAA_17 PF13207.1 KOG97701.1 - 8.7e-06 26.5 0.7 0.13 13.1 0.0 3.4 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 KOG97701.1 - 3.8e-05 23.7 0.2 0.26 11.2 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.1 KOG97701.1 - 0.00031 20.1 0.0 0.91 8.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 KOG97701.1 - 0.00033 21.0 5.7 0.021 15.1 0.2 3.2 2 2 0 2 2 2 1 AAA domain T2SE PF00437.15 KOG97701.1 - 0.0004 19.3 0.0 0.78 8.5 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_33 PF13671.1 KOG97701.1 - 0.00041 20.2 0.1 0.83 9.5 0.0 3.5 3 0 0 3 3 3 1 AAA domain DUF87 PF01935.12 KOG97701.1 - 0.00084 19.2 0.4 0.12 12.1 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function DUF87 Miro PF08477.8 KOG97701.1 - 0.0016 18.9 0.5 2.7 8.4 0.0 3.7 3 0 0 3 3 3 1 Miro-like protein AAA_22 PF13401.1 KOG97701.1 - 0.002 18.2 2.9 1 9.5 0.0 3.8 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KOG97701.1 - 0.0027 17.9 0.0 0.68 10.2 0.0 3.1 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 KOG97701.1 - 0.0043 16.2 0.0 1.3 8.2 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 KOG97701.1 - 0.0087 15.8 6.6 0.017 14.9 0.1 3.3 3 0 0 3 3 3 1 Dynamin family AAA_30 PF13604.1 KOG97701.1 - 0.0099 15.4 0.1 1.9 8.0 0.0 2.9 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.7 KOG97701.1 - 0.013 14.5 0.1 4.1 6.4 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin ArgK PF03308.11 KOG97701.1 - 0.016 14.0 0.0 2.5 6.8 0.0 2.3 2 0 0 2 2 2 0 ArgK protein MobB PF03205.9 KOG97701.1 - 0.016 14.9 0.3 7 6.3 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B GTP_EFTU PF00009.22 KOG97701.1 - 0.023 14.1 0.0 2.4 7.5 0.0 2.7 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain NB-ARC PF00931.17 KOG97701.1 - 0.024 13.5 1.5 7.2 5.3 0.0 3.4 4 0 0 4 4 4 0 NB-ARC domain UPF0079 PF02367.12 KOG97701.1 - 0.026 14.1 0.0 0.21 11.2 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 FtsK_SpoIIIE PF01580.13 KOG97701.1 - 0.033 13.6 0.0 2.8 7.3 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family NACHT PF05729.7 KOG97701.1 - 0.046 13.3 0.4 0.8 9.3 0.0 2.8 3 0 0 3 3 2 0 NACHT domain Rab5ip PF07019.7 KOG97702.1 - 9.9e-15 54.4 4.6 1.2e-14 54.1 3.2 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) PUF PF00806.14 KOG97703.1 - 3.5e-58 189.9 16.9 3.5e-07 29.3 0.0 8.7 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Abhydro_lipase PF04083.11 KOG97704.1 - 1.7e-16 59.3 0.0 3e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_6 PF12697.2 KOG97704.1 - 1.5e-05 25.0 0.0 2.4e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOG97704.1 - 0.056 12.9 0.0 0.14 11.6 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold WD40 PF00400.27 KOG97705.1 - 7e-34 114.4 7.6 1.7e-08 34.0 0.0 6.4 7 0 0 7 7 7 5 WD domain, G-beta repeat Sof1 PF04158.9 KOG97705.1 - 1.7e-28 98.4 13.3 1.7e-28 98.4 9.2 2.3 2 0 0 2 2 2 1 Sof1-like domain eIF2A PF08662.6 KOG97705.1 - 4.3e-05 23.3 2.7 0.00042 20.0 0.2 2.5 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.1 KOG97705.1 - 0.0017 18.1 1.2 0.023 14.4 0.0 3.3 4 1 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region NIF PF03031.13 KOG97706.1 - 1.5e-49 167.7 0.2 3.2e-49 166.6 0.2 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Ycf1 PF05758.7 KOG97706.1 - 0.16 9.6 9.1 0.2 9.3 6.3 1.1 1 0 0 1 1 1 0 Ycf1 CDC27 PF09507.5 KOG97706.1 - 8.9 5.4 32.1 12 4.9 22.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 COX17 PF05051.8 KOG97707.1 - 4.6e-21 74.5 8.5 4.6e-21 74.5 5.9 2.2 2 1 0 2 2 2 1 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.8 KOG97707.1 - 0.0002 21.1 4.0 0.0002 21.1 2.8 2.7 2 1 0 2 2 2 1 CHCH domain Cmc1 PF08583.5 KOG97707.1 - 0.0008 19.1 0.1 0.0008 19.1 0.1 3.2 2 2 1 3 3 3 1 Cytochrome c oxidase biogenesis protein Cmc1 like Trypan_PARP PF05887.6 KOG97707.1 - 1.6 8.5 4.7 1.8 8.3 3.3 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CRAM_rpt PF07016.6 KOG97707.1 - 5 6.5 10.7 16 4.9 7.4 2.0 1 0 0 1 1 1 0 Cysteine-rich acidic integral membrane protein precursor DEAD PF00270.24 KOG97708.1 - 2.6e-44 150.7 0.2 8e-44 149.1 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG97708.1 - 5.4e-25 87.0 0.0 1.8e-24 85.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF2404 PF10296.4 KOG97710.1 - 7.5e-06 25.9 0.0 4.2e-05 23.6 0.0 2.1 2 0 0 2 2 2 1 Putative integral membrane protein conserved region (DUF2404) DUF221 PF02714.10 KOG97711.1 - 1.2e-83 280.6 28.3 1.2e-83 280.6 19.6 2.1 3 0 0 3 3 3 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 KOG97711.1 - 4.8e-21 74.9 8.2 4.8e-21 74.9 5.7 3.3 2 2 1 3 3 3 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 KOG97711.1 - 0.0065 16.3 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Phosphate metabolism protein Sfi1 PF08457.5 KOG97713.1 - 2e-105 353.3 63.5 2e-105 353.3 44.0 2.0 1 1 1 2 2 2 2 Sfi1 spindle body protein Sfi1_C PF10638.4 KOG97713.1 - 3e-39 133.8 3.2 8.1e-39 132.3 2.2 1.8 1 0 0 1 1 1 1 Spindle body associated protein C-terminus TFIIS_C PF01096.13 KOG97713.1 - 0.063 12.9 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS) KAT11 PF08214.6 KOG97714.1 - 2.4e-100 336.0 0.4 2.9e-100 335.7 0.3 1.0 1 0 0 1 1 1 1 Histone acetylation protein Dynamin_M PF01031.15 KOG97715.1 - 1.2e-112 375.5 0.1 1.9e-112 374.8 0.1 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 KOG97715.1 - 1.3e-54 184.5 0.0 3.1e-54 183.2 0.0 1.7 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 KOG97715.1 - 1.2e-28 98.8 1.5 3.2e-28 97.4 1.0 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 KOG97715.1 - 0.0016 18.3 0.2 0.022 14.7 0.2 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase zf-CCHC_4 PF14392.1 KOG97715.1 - 0.021 14.5 0.1 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 Zinc knuckle Miro PF08477.8 KOG97715.1 - 0.031 14.7 0.0 0.084 13.3 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein Utp12 PF04003.7 KOG97715.1 - 0.078 12.8 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Dip2/Utp12 Family Fasciclin PF02469.17 KOG97716.1 - 4.9e-20 71.8 2.9 9.1e-08 32.1 0.1 5.3 5 1 0 5 5 5 4 Fasciclin domain DUF1132 PF06575.7 KOG97716.1 - 0.028 14.6 0.4 0.12 12.6 0.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1132) CMS1 PF14617.1 KOG97717.1 - 4.9e-16 58.5 12.5 4.2e-15 55.5 8.7 2.2 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit VitD-bind_III PF09164.5 KOG97717.1 - 0.11 12.1 0.4 0.53 9.9 0.0 2.2 1 1 1 2 2 2 0 Vitamin D binding protein, domain III DUF849 PF05853.7 KOG97717.1 - 0.13 11.1 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic protein of unknown function (DUF849) WBS_methylT PF12589.3 KOG97717.1 - 0.52 10.8 10.2 1.1 9.7 7.0 1.5 1 0 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome CAF1A PF12253.3 KOG97717.1 - 2.9 8.0 7.6 5.9 7.0 5.3 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A MFS_1 PF07690.11 KOG97718.1 - 1.1e-35 123.0 23.7 1.6e-35 122.5 16.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4658 PF15555.1 KOG97718.1 - 0.16 11.8 0.1 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) Ssl1 PF04056.9 KOG97719.1 - 5.4e-90 300.1 0.1 7.2e-90 299.7 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.7 KOG97719.1 - 3.8e-20 71.6 11.5 3.8e-20 71.6 8.0 2.9 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.1 KOG97719.1 - 2.9e-13 50.2 0.0 4.1e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain IBR PF01485.16 KOG97719.1 - 0.011 15.5 6.2 0.011 15.5 4.3 2.9 2 1 0 2 2 2 0 IBR domain Taeniidae_ag PF05596.6 KOG97719.1 - 0.032 14.0 0.0 0.097 12.4 0.0 1.8 1 0 0 1 1 1 0 Taeniidae antigen VWA PF00092.23 KOG97719.1 - 0.037 13.7 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain zf-HIT PF04438.11 KOG97719.1 - 0.35 10.5 18.9 0.61 9.7 4.8 3.2 3 0 0 3 3 3 0 HIT zinc finger DZR PF12773.2 KOG97719.1 - 8.5 6.2 23.4 1.9 8.3 4.9 3.4 2 1 0 2 2 2 0 Double zinc ribbon Response_reg PF00072.19 KOG97720.1 - 7.2e-20 71.0 0.0 2e-13 50.2 0.0 2.3 1 1 1 2 2 2 2 Response regulator receiver domain SMC_Nse1 PF07574.8 KOG97721.1 - 6.6e-48 162.9 0.0 8.1e-48 162.7 0.0 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.6 KOG97721.1 - 3.9e-15 55.5 11.7 7.2e-15 54.7 8.1 1.5 1 0 0 1 1 1 1 RING-like domain XPA_N PF01286.13 KOG97721.1 - 0.04 13.6 0.5 1.5 8.5 0.0 2.7 2 0 0 2 2 2 0 XPA protein N-terminal DUF1883 PF08980.5 KOG97721.1 - 0.04 13.4 0.0 0.08 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1883) DnaJ PF00226.26 KOG97722.1 - 1.7e-05 24.4 0.0 2.9e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.8 KOG97722.1 - 0.00043 20.0 0.1 0.00054 19.7 0.1 1.2 1 0 0 1 1 1 1 Pam16 Ribosomal_L24e PF01246.15 KOG97723.1 - 1.7e-28 98.2 2.5 4.5e-28 96.9 1.7 1.8 1 0 0 1 1 1 1 Ribosomal protein L24e TFIIF_alpha PF05793.7 KOG97723.1 - 0.029 12.7 15.6 0.037 12.4 10.8 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) zf-FCS PF06467.9 KOG97723.1 - 0.34 10.5 5.9 0.64 9.7 4.1 1.4 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif Sec62 PF03839.11 KOG97723.1 - 0.97 8.8 11.1 1.8 7.9 7.7 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 AAA_23 PF13476.1 KOG97723.1 - 2.5 8.3 13.3 3 8.1 9.2 1.2 1 0 0 1 1 1 0 AAA domain Nucleoplasmin PF03066.10 KOG97723.1 - 3.7 7.0 11.1 5.6 6.4 7.7 1.2 1 0 0 1 1 1 0 Nucleoplasmin YqfQ PF14181.1 KOG97723.1 - 5.9 6.9 11.2 9.9 6.1 7.8 1.3 1 0 0 1 1 1 0 YqfQ-like protein GOLD_2 PF13897.1 KOG97723.1 - 9.4 6.4 7.9 52 4.0 0.0 2.3 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking Ten1 PF12658.2 KOG97724.1 - 4.4e-06 26.4 0.0 5.6e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Telomere capping, CST complex subunit FMN_red PF03358.10 KOG97725.1 - 1.4e-30 105.8 0.0 1.8e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 KOG97725.1 - 8.4e-09 35.2 0.0 1.1e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold GATA PF00320.22 KOG97727.1 - 5.8e-14 51.1 0.3 1.3e-13 50.0 0.2 1.6 1 0 0 1 1 1 1 GATA zinc finger GSu_C4xC__C2xCH PF09698.5 KOG97727.1 - 3.4 7.9 5.8 3.4 7.9 2.9 2.1 2 1 0 2 2 2 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) Fungal_trans PF04082.13 KOG97728.1 - 1.1e-47 162.1 6.1 2.1e-47 161.1 1.9 2.8 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG97728.1 - 3.4e-10 39.6 11.8 5.9e-10 38.8 8.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SPRY PF00622.23 KOG97729.1 - 0.0046 17.0 0.4 0.048 13.7 0.0 2.7 2 1 0 2 2 2 1 SPRY domain PRKCSH PF07915.8 KOG97729.1 - 0.041 14.6 0.4 15 6.4 0.0 2.9 2 0 0 2 2 2 0 Glucosidase II beta subunit-like protein FHA PF00498.21 KOG97730.1 - 1.5e-13 50.6 0.1 2.7e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 FHA domain PNP_UDP_1 PF01048.15 KOG97731.1 - 1.3e-32 112.6 0.0 1.6e-32 112.3 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily NPCC PF08058.6 KOG97732.1 - 1.7e-38 131.6 0.5 2.7e-38 131.0 0.3 1.3 1 0 0 1 1 1 1 Nuclear pore complex component CytochromB561_N PF09786.4 KOG97732.1 - 1.7e-05 23.5 0.2 2.2e-05 23.1 0.2 1.3 1 0 0 1 1 1 1 Cytochrome B561, N terminal DUF570 PF04489.8 KOG97732.1 - 0.033 12.6 0.0 0.077 11.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF570) NIF PF03031.13 KOG97733.1 - 3.6e-51 172.9 0.4 7.2e-51 171.9 0.3 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD_2 PF13419.1 KOG97733.1 - 0.076 13.2 0.1 1.4 9.1 0.0 2.3 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase Abhydro_lipase PF04083.11 KOG97734.1 - 4.2e-16 58.0 0.0 8.5e-16 57.0 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_6 PF12697.2 KOG97734.1 - 5.5e-05 23.1 0.0 8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOG97734.1 - 0.0035 16.9 0.0 0.0075 15.8 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold chaperone_DMP PF10448.4 KOG97735.1 - 3.3e-42 143.8 0.0 3.7e-42 143.6 0.0 1.0 1 0 0 1 1 1 1 20S proteasome chaperone SBDS_C PF09377.5 KOG97736.1 - 2e-36 124.4 3.8 2.8e-36 123.9 0.6 2.1 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.13 KOG97736.1 - 3.5e-33 113.2 2.5 5.2e-33 112.7 1.7 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein HlyIII PF03006.15 KOG97737.1 - 4.1e-77 258.5 19.9 5.4e-77 258.1 13.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related zf-UBR PF02207.15 KOG97738.1 - 3.5e-13 49.0 8.5 3.5e-13 49.0 5.9 3.2 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) Snf7 PF03357.16 KOG97739.1 - 1.3e-53 180.8 18.6 1.3e-53 180.8 12.9 2.0 2 0 0 2 2 2 1 Snf7 CHASE3 PF05227.8 KOG97739.1 - 0.01 15.4 3.8 0.01 15.4 2.6 2.2 1 1 1 2 2 2 0 CHASE3 domain Mut7-C PF01927.11 KOG97739.1 - 0.071 13.0 0.3 0.19 11.6 0.2 1.8 1 1 0 1 1 1 0 Mut7-C RNAse domain DUF4388 PF14332.1 KOG97739.1 - 0.083 12.7 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4388) Snapin_Pallidin PF14712.1 KOG97739.1 - 2.2 8.6 17.7 0.039 14.2 4.3 3.4 2 2 3 5 5 5 0 Snapin/Pallidin Syntaxin PF00804.20 KOG97740.1 - 1e-19 70.5 3.8 1e-19 70.5 2.6 4.0 3 1 0 3 3 3 1 Syntaxin SNARE PF05739.14 KOG97740.1 - 1.7e-18 66.0 3.9 1.7e-18 66.0 2.7 2.6 3 0 0 3 3 3 1 SNARE domain Sed5p PF11416.3 KOG97740.1 - 2.1e-13 49.4 6.0 2.1e-13 49.4 4.2 2.6 3 0 0 3 3 3 1 Integral membrane protein Sed5p Syntaxin-18_N PF10496.4 KOG97740.1 - 0.0012 18.6 1.4 0.0012 18.6 1.0 2.7 2 1 1 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus MCPsignal PF00015.16 KOG97740.1 - 0.023 14.2 1.2 0.023 14.2 0.8 3.3 1 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.7 KOG97740.1 - 3.9 7.3 10.3 0.18 11.6 0.4 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Aminotran_1_2 PF00155.16 KOG97741.1 - 2e-79 267.1 0.1 2.3e-79 266.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II AICARFT_IMPCHas PF01808.13 KOG97743.1 - 2.8e-125 417.5 0.0 3.6e-125 417.2 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.17 KOG97743.1 - 3.4e-25 87.8 0.0 8.1e-25 86.5 0.0 1.7 1 0 0 1 1 1 1 MGS-like domain Ribosomal_L15e PF00827.12 KOG97744.1 - 6.4e-91 303.0 14.9 7.4e-91 302.8 10.3 1.0 1 0 0 1 1 1 1 Ribosomal L15 SNF2_N PF00176.18 KOG97746.1 - 4.8e-66 222.5 0.2 7.5e-66 221.9 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.6 KOG97746.1 - 2e-15 56.5 0.0 5e-15 55.3 0.0 1.7 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.26 KOG97746.1 - 1.1e-10 41.2 0.0 2.6e-10 40.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.1 KOG97746.1 - 3.9e-09 36.1 5.7 7.2e-09 35.3 3.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOG97746.1 - 1.5e-08 34.1 3.0 2.6e-08 33.4 2.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOG97746.1 - 5e-08 32.8 7.1 9.2e-08 31.9 5.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOG97746.1 - 2.5e-07 30.2 7.5 4.5e-07 29.4 5.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOG97746.1 - 1.5e-06 27.8 7.3 2.8e-06 26.9 5.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain DEAD PF00270.24 KOG97746.1 - 3.1e-05 23.5 0.0 7.3e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_4 PF15227.1 KOG97746.1 - 0.001 18.8 8.7 0.002 17.9 6.0 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 KOG97746.1 - 0.0015 18.2 3.0 0.0043 16.7 2.1 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.2 KOG97746.1 - 0.013 15.5 1.8 0.03 14.4 1.3 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING_4 PF14570.1 KOG97746.1 - 0.013 15.0 6.1 0.026 14.1 4.2 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 KOG97746.1 - 0.031 14.0 0.8 0.067 13.0 0.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger AAA_22 PF13401.1 KOG97746.1 - 0.086 12.9 0.0 1.1 9.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain zf-RING_6 PF14835.1 KOG97746.1 - 0.099 12.4 2.2 0.23 11.2 1.5 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Bromodomain PF00439.20 KOG97747.1 - 1.7e-07 31.0 0.1 4.4e-07 29.7 0.1 1.7 1 0 0 1 1 1 1 Bromodomain Nramp PF01566.13 KOG97748.1 - 1.1e-96 323.8 13.3 1.3e-96 323.4 9.2 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein DNA_mis_repair PF01119.14 KOG97749.1 - 8e-11 41.4 0.2 1.4e-10 40.6 0.2 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 KOG97749.1 - 4.8e-10 39.2 1.4 7.6e-10 38.5 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOG97749.1 - 1.4e-09 37.6 0.1 3.1e-09 36.5 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3328 PF11807.3 KOG97750.1 - 0.057 13.0 1.6 1.5 8.4 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) SRP1_TIP1 PF00660.12 KOG97751.1 - 2.4e-32 110.8 0.1 3.1e-32 110.5 0.1 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family COX6B PF02297.12 KOG97752.1 - 2.3e-20 72.3 5.1 2.6e-20 72.1 3.6 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Somatostatin PF03002.10 KOG97752.1 - 0.077 12.6 0.2 0.18 11.4 0.1 1.6 1 0 0 1 1 1 0 Somatostatin/Cortistatin family ketoacyl-synt PF00109.21 KOG97752.1 - 0.097 12.1 0.0 0.1 12.0 0.0 1.0 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain APOBEC_C PF05240.9 KOG97752.1 - 0.11 11.8 2.8 0.27 10.6 2.0 1.7 1 1 0 1 1 1 0 APOBEC-like C-terminal domain UCR_hinge PF02320.11 KOG97752.1 - 0.17 11.8 1.6 0.26 11.2 0.8 1.6 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein UPF0203 PF05254.7 KOG97752.1 - 0.46 10.3 5.9 1.2 9.0 1.0 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) RIC1 PF07064.8 KOG97753.1 - 1.7e-11 44.0 4.3 7.5e-11 41.9 2.9 2.1 1 1 0 1 1 1 1 RIC1 SRP1_TIP1 PF00660.12 KOG97754.1 - 2.2e-07 30.6 0.6 2.2e-07 30.6 0.4 1.8 2 0 0 2 2 2 1 Seripauperin and TIP1 family Suf PF05843.9 KOG97754.1 - 0.0083 15.8 1.8 0.011 15.4 1.2 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) DNA_pol_viral_N PF00242.12 KOG97754.1 - 1.8 7.4 11.0 2.6 7.0 7.6 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain RAP1 PF07218.6 KOG97754.1 - 2.4 6.1 15.4 3.1 5.7 10.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PAP1 PF08601.5 KOG97754.1 - 3.3 7.2 16.6 5.7 6.5 11.5 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 Macoilin PF09726.4 KOG97754.1 - 6.8 4.8 12.0 8.7 4.4 8.3 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF515 PF04415.7 KOG97754.1 - 10 4.2 17.5 14 3.7 12.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Thioredoxin PF00085.15 KOG97756.1 - 6e-33 112.6 0.6 6.6e-33 112.5 0.4 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 KOG97756.1 - 1.8e-09 37.7 0.4 6.2e-08 32.8 0.3 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOG97756.1 - 1.3e-08 34.8 0.1 2.7e-06 27.3 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_9 PF14595.1 KOG97756.1 - 1.7e-07 30.8 0.1 2e-07 30.6 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.16 KOG97756.1 - 5.8e-06 26.0 0.1 7.1e-06 25.7 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KOG97756.1 - 1.1e-05 25.0 0.1 6.2e-05 22.5 0.0 1.8 1 1 1 2 2 2 1 Redoxin Thioredoxin_7 PF13899.1 KOG97756.1 - 0.00048 20.0 0.1 0.00093 19.1 0.1 1.7 1 1 0 1 1 1 1 Thioredoxin-like DIM1 PF02966.11 KOG97756.1 - 0.0013 18.2 0.0 0.0015 18.0 0.0 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 TraF PF13728.1 KOG97756.1 - 0.013 15.0 0.1 0.033 13.6 0.1 1.6 1 1 0 1 1 1 0 F plasmid transfer operon protein HyaE PF07449.6 KOG97756.1 - 0.061 13.2 0.0 0.099 12.5 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Phosducin PF02114.11 KOG97756.1 - 0.08 11.6 0.0 0.085 11.5 0.0 1.0 1 0 0 1 1 1 0 Phosducin TPP_enzyme_M PF00205.17 KOG97757.1 - 2.4e-36 124.5 0.0 1.1e-35 122.3 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N PF02776.13 KOG97757.1 - 5.6e-34 117.1 0.1 8.3e-34 116.5 0.1 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 KOG97757.1 - 2.6e-14 53.0 0.0 4.7e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain OCC1 PF15506.1 KOG97757.1 - 0.02 14.7 0.3 0.75 9.7 0.0 2.7 2 0 0 2 2 2 0 OCC1 family Cnd3 PF12719.2 KOG97758.1 - 2.6e-06 26.6 0.2 0.00011 21.2 0.1 2.5 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT PF02985.17 KOG97758.1 - 0.0039 17.1 0.0 3.7 7.8 0.0 4.8 5 0 0 5 5 5 1 HEAT repeat NeuB PF03102.9 KOG97758.1 - 0.044 12.9 2.7 0.4 9.7 1.4 2.2 2 0 0 2 2 2 0 NeuB family RTA1 PF04479.8 KOG97759.1 - 9.8e-76 254.1 16.7 1.3e-75 253.7 11.6 1.2 1 0 0 1 1 1 1 RTA1 like protein Ferric_reduct PF01794.14 KOG97760.1 - 2.7e-17 63.0 14.0 7.3e-17 61.6 9.7 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 KOG97760.1 - 0.0033 17.2 0.1 0.0082 15.9 0.1 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 KOG97760.1 - 0.017 15.0 0.0 0.057 13.3 0.0 2.0 1 1 0 1 1 1 0 Ferric reductase NAD binding domain Ribosomal_S2 PF00318.15 KOG97761.1 - 1e-40 139.2 0.0 1.6e-20 73.2 0.0 2.6 2 1 1 3 3 3 2 Ribosomal protein S2 DUF2781 PF10914.3 KOG97763.1 - 2.5e-36 124.7 10.1 2.8e-36 124.5 7.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Fcf2 PF08698.6 KOG97764.1 - 5.6e-32 109.6 4.1 5.6e-32 109.6 2.8 1.7 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing Phi-29_GP3 PF05435.6 KOG97765.1 - 0.026 13.7 2.3 0.042 13.0 1.3 1.6 1 1 1 2 2 2 0 Phi-29 DNA terminal protein GP3 WD40 PF00400.27 KOG97768.1 - 3.6e-11 42.4 0.1 0.039 13.8 0.0 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat FA_hydroxylase PF04116.8 KOG97769.1 - 2.5e-11 43.9 19.1 2.5e-11 43.9 13.2 2.3 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Glyco_hydro_47 PF01532.15 KOG97770.1 - 4.8e-72 243.0 0.0 7.9e-72 242.3 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 SHMT PF00464.14 KOG97771.1 - 1.3e-206 685.6 0.0 1.5e-206 685.4 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_5 PF00266.14 KOG97771.1 - 1.7e-06 27.0 0.0 2.4e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 KOG97771.1 - 5.6e-05 22.2 0.0 0.00011 21.3 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOG97771.1 - 0.0014 17.8 0.0 0.0035 16.5 0.0 1.7 1 1 1 2 2 2 1 Beta-eliminating lyase RNase_T PF00929.19 KOG97772.1 - 2.2e-37 128.8 0.1 2.8e-37 128.5 0.0 1.1 1 0 0 1 1 1 1 Exonuclease FliD_N PF02465.13 KOG97772.1 - 0.025 14.9 0.5 0.045 14.1 0.3 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus B3_4 PF03483.12 KOG97773.1 - 9.8e-27 93.5 0.1 2.1e-26 92.4 0.0 1.6 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.10 KOG97773.1 - 5.4e-16 58.1 0.1 7.4e-14 51.3 0.0 2.7 2 0 0 2 2 2 2 tRNA synthetase B5 domain SLS PF14611.1 KOG97773.1 - 0.022 14.1 0.6 0.27 10.6 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial inner-membrane-bound regulator Ribosomal_L22e PF01776.12 KOG97774.1 - 4.7e-43 145.7 0.7 5.7e-43 145.4 0.5 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family DUF3115 PF11312.3 KOG97775.1 - 1.9e-107 358.7 0.2 2.2e-107 358.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3115) UPF0121 PF03661.8 KOG97776.1 - 0.00022 20.5 21.2 0.00043 19.5 14.7 1.4 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0121) DUF788 PF05620.6 KOG97777.1 - 2.1e-48 164.3 0.2 2.4e-48 164.2 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF788) DUF2142 PF09913.4 KOG97777.1 - 0.028 13.1 1.0 0.035 12.7 0.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) 2TM PF13239.1 KOG97777.1 - 2 8.5 5.7 0.23 11.5 0.2 2.0 2 0 0 2 2 2 0 2TM domain SPC22 PF04573.7 KOG97778.1 - 1.1e-62 210.4 7.0 1.2e-62 210.2 4.9 1.0 1 0 0 1 1 1 1 Signal peptidase subunit DUF4363 PF14276.1 KOG97778.1 - 1.4 8.6 5.4 9.5 5.9 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) PPR PF01535.15 KOG97779.1 - 1.7e-07 30.7 0.1 23 5.2 0.0 8.4 8 0 0 8 8 8 1 PPR repeat PPR_3 PF13812.1 KOG97779.1 - 3.9e-07 29.8 9.5 11 6.5 0.0 10.6 14 0 0 14 14 14 1 Pentatricopeptide repeat domain PPR_2 PF13041.1 KOG97779.1 - 7.2e-05 22.6 19.2 3 7.8 0.0 9.5 8 3 4 12 12 12 3 PPR repeat family TPR_14 PF13428.1 KOG97779.1 - 0.0058 17.1 0.0 22 6.0 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOG97779.1 - 0.013 15.8 0.0 18 5.7 0.0 3.5 2 1 2 4 4 4 0 Tetratricopeptide repeat ATP13 PF12921.2 KOG97779.1 - 0.02 14.2 6.1 0.16 11.3 0.3 3.9 4 0 0 4 4 4 0 Mitochondrial ATPase expression rRNA_processing PF08524.6 KOG97780.1 - 1.2e-49 167.8 30.5 1.3e-49 167.7 21.1 1.0 1 0 0 1 1 1 1 rRNA processing APG6 PF04111.7 KOG97780.1 - 9.8 5.1 11.5 12 4.8 8.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 GTP_EFTU PF00009.22 KOG97781.1 - 5.9e-59 198.6 0.1 1.3e-58 197.6 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 KOG97781.1 - 8.9e-35 118.8 0.0 2.1e-34 117.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.1 KOG97781.1 - 1e-29 102.1 0.0 2.3e-29 101.0 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 KOG97781.1 - 4.3e-24 84.2 0.0 9.3e-24 83.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 KOG97781.1 - 1.8e-13 50.3 0.9 4.4e-13 49.1 0.2 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Miro PF08477.8 KOG97781.1 - 0.0019 18.6 0.0 0.005 17.3 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein ADH_zinc_N PF00107.21 KOG97782.1 - 2.7e-30 104.5 0.1 5e-30 103.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOG97782.1 - 1.1e-26 92.6 0.0 6.5e-26 90.2 0.0 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 KOG97782.1 - 7.9e-05 23.5 0.0 0.00017 22.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.9 KOG97782.1 - 0.0038 16.6 0.1 0.0092 15.3 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Med14 PF08638.6 KOG97783.1 - 1.4e-64 216.9 5.4 4.9e-64 215.1 3.7 2.0 1 0 0 1 1 1 1 Mediator complex subunit MED14 CDT1 PF08839.6 KOG97783.1 - 0.00044 20.2 1.1 0.0013 18.7 0.8 1.7 1 0 0 1 1 1 1 DNA replication factor CDT1 like GRAM PF02893.15 KOG97784.1 - 5.8e-18 64.1 0.1 1.1e-17 63.2 0.1 1.5 1 0 0 1 1 1 1 GRAM domain USP8_dimer PF08969.6 KOG97785.1 - 8.9e-06 25.6 0.0 2.2e-05 24.4 0.0 1.8 1 1 0 1 1 1 1 USP8 dimerisation domain zf-C2H2_jaz PF12171.3 KOG97786.1 - 2.6e-09 36.9 3.5 2.6e-09 36.9 2.5 1.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 KOG97786.1 - 0.0012 18.9 0.1 0.0019 18.2 0.1 1.3 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.7 KOG97786.1 - 0.036 13.6 1.2 0.068 12.7 0.8 1.4 1 0 0 1 1 1 0 U1 zinc finger zf-met PF12874.2 KOG97786.1 - 0.35 11.1 3.9 0.24 11.6 1.6 1.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Ribosomal_L16 PF00252.13 KOG97787.1 - 1e-33 115.9 0.1 1.4e-33 115.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e RCC1 PF00415.13 KOG97788.1 - 2.2e-24 85.4 0.1 9.1e-05 22.5 0.0 6.2 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOG97788.1 - 3.6e-13 48.7 5.2 1.1e-09 37.6 0.0 4.4 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat V-SNARE_C PF12352.3 KOG97789.1 - 4.5e-07 29.8 2.2 6e-07 29.4 1.6 1.2 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 KOG97789.1 - 2.4e-05 23.9 0.6 3.4e-05 23.4 0.4 1.2 1 0 0 1 1 1 1 Sec20 Lectin_leg-like PF03388.8 KOG97791.1 - 4.4e-32 111.0 0.0 6.2e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Chordopox_G3 PF06129.7 KOG97791.1 - 0.089 12.9 1.4 0.15 12.2 0.0 2.1 2 0 0 2 2 2 0 Chordopoxvirus G3 protein Sugar_tr PF00083.19 KOG97792.1 - 1.1e-170 568.1 36.9 1.2e-170 567.9 25.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG97792.1 - 6.2e-31 107.3 31.8 1.1e-27 96.6 13.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily LMF1 PF06762.9 KOG97792.1 - 0.0037 16.1 1.4 0.0062 15.3 1.0 1.5 1 0 0 1 1 1 1 Lipase maturation factor Sugar_tr PF00083.19 KOG97793.1 - 1e-170 568.1 36.9 1.2e-170 567.9 25.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG97793.1 - 5.3e-31 107.6 31.6 8.5e-28 97.0 13.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily LMF1 PF06762.9 KOG97793.1 - 0.0037 16.1 1.4 0.0062 15.3 1.0 1.4 1 0 0 1 1 1 1 Lipase maturation factor DUF2267 PF10025.4 KOG97794.1 - 0.021 14.8 0.1 0.042 13.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) EMP24_GP25L PF01105.19 KOG97794.1 - 5.2 6.7 7.1 8.7 6.0 0.1 2.9 2 1 1 3 3 3 0 emp24/gp25L/p24 family/GOLD EMP70 PF02990.11 KOG97795.1 - 4.4e-213 708.4 8.9 1e-212 707.2 6.2 1.5 2 0 0 2 2 2 1 Endomembrane protein 70 Lamp PF01299.12 KOG97795.1 - 0.2 10.7 0.0 0.33 10.0 0.0 1.2 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) Rax2 PF12768.2 KOG97796.1 - 6.7e-71 238.7 28.5 1.2e-68 231.4 1.2 4.8 4 0 0 4 4 4 4 Cortical protein marker for cell polarity Actin PF00022.14 KOG97797.1 - 5.9e-55 186.2 0.0 7.4e-55 185.9 0.0 1.1 1 0 0 1 1 1 1 Actin SMC_N PF02463.14 KOG97798.1 - 1.6e-81 272.7 9.1 3.7e-81 271.5 6.3 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 KOG97798.1 - 1.2e-27 96.2 0.0 4.6e-27 94.3 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 KOG97798.1 - 7.1e-08 32.7 38.6 3.6e-06 27.1 0.2 5.4 2 2 1 4 4 4 2 AAA domain AAA_29 PF13555.1 KOG97798.1 - 0.00017 21.0 0.0 0.00039 19.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.7 KOG97798.1 - 0.72 8.9 38.5 0.12 11.5 4.0 4.8 2 2 3 5 5 5 0 Reovirus sigma C capsid protein Snurportin1 PF11538.3 KOG97798.1 - 3.2 7.5 10.8 0.15 11.8 1.6 3.2 3 0 0 3 3 3 0 Snurportin1 Gaa1 PF04114.9 KOG97800.1 - 1.1e-179 598.3 9.4 1.4e-179 598.0 6.5 1.1 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component Aminotran_1_2 PF00155.16 KOG97801.1 - 3.4e-36 124.9 0.0 5.1e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOG97801.1 - 0.00085 18.5 0.0 0.0015 17.7 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase MTD PF01993.13 KOG97801.1 - 0.14 11.1 0.2 0.23 10.4 0.1 1.2 1 0 0 1 1 1 0 methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase DnaJ PF00226.26 KOG97802.1 - 4.7e-24 83.9 1.6 9e-24 83.0 1.1 1.5 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 KOG97802.1 - 1.4e-17 63.3 0.0 3.2e-15 55.7 0.0 2.5 2 0 0 2 2 2 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 KOG97802.1 - 6.6e-09 35.6 26.6 1.1e-07 31.8 8.8 2.2 1 1 1 2 2 2 2 DnaJ central domain zf-CHY PF05495.7 KOG97802.1 - 0.0011 19.1 4.8 0.23 11.6 0.1 2.4 2 0 0 2 2 2 2 CHY zinc finger Cytochrome_C554 PF13435.1 KOG97802.1 - 0.025 14.6 3.7 0.069 13.2 2.6 1.8 1 0 0 1 1 1 0 Cytochrome c554 and c-prime SprT-like PF10263.4 KOG97802.1 - 0.083 12.5 0.5 0.15 11.7 0.3 1.5 1 0 0 1 1 1 0 SprT-like family Cytochrom_c3_2 PF14537.1 KOG97802.1 - 0.63 10.4 8.9 1.7 9.0 3.5 2.2 1 1 1 2 2 2 0 Cytochrome c3 Cytochrome_C7 PF14522.1 KOG97802.1 - 2.1 8.0 9.3 0.92 9.1 4.2 2.1 1 1 1 2 2 2 0 Cytochrome c7 Sulfate_transp PF00916.15 KOG97804.1 - 4.7e-91 304.6 1.8 4.7e-91 304.6 1.2 1.8 2 0 0 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 KOG97804.1 - 2.3e-30 104.1 4.8 2.3e-30 104.1 3.3 2.1 2 0 0 2 2 2 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 KOG97804.1 - 0.00024 20.5 0.0 0.00053 19.3 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 KOG97804.1 - 0.0072 16.3 0.1 0.022 14.7 0.1 1.8 2 0 0 2 2 2 1 STAS domain Nyv1_N PF09426.5 KOG97805.1 - 1.5e-45 154.2 0.6 2.5e-45 153.5 0.4 1.4 1 0 0 1 1 1 1 Vacuolar R-SNARE Nyv1 N terminal Synaptobrevin PF00957.16 KOG97805.1 - 2.4e-26 91.1 3.7 3.7e-26 90.5 2.5 1.2 1 0 0 1 1 1 1 Synaptobrevin PHD PF00628.24 KOG97807.1 - 0.0013 18.3 1.3 0.0013 18.3 0.9 2.0 2 0 0 2 2 2 1 PHD-finger TFIIA PF03153.8 KOG97807.1 - 0.55 10.0 7.6 1.3 8.8 5.2 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.20 KOG97808.1 - 1.9e-69 233.7 0.6 6.9e-69 231.8 0.4 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97808.1 - 1.6e-37 128.9 0.4 8e-37 126.7 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase KA1 PF02149.14 KOG97808.1 - 3.1e-19 68.1 0.0 5.8e-19 67.2 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.1 KOG97808.1 - 1e-06 27.9 0.0 2e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG97808.1 - 5.6e-05 22.2 0.0 0.00014 20.9 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 KOG97808.1 - 0.0061 15.8 0.3 0.011 15.0 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 KOG97808.1 - 0.0061 16.3 0.0 0.026 14.2 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOG97808.1 - 0.029 13.7 0.0 0.029 13.7 0.0 2.2 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL F-box-like PF12937.2 KOG97809.1 - 0.00036 20.1 0.0 0.00067 19.3 0.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 KOG97809.1 - 0.0008 19.0 0.5 0.0017 17.9 0.3 1.5 1 0 0 1 1 1 1 F-box domain MIT PF04212.13 KOG97809.1 - 0.068 13.0 0.0 0.3 10.9 0.0 2.1 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Fungal_trans PF04082.13 KOG97810.1 - 1.7e-40 138.5 3.5 3.4e-40 137.5 2.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG97810.1 - 3.1e-11 42.9 11.2 5.2e-11 42.2 7.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.20 KOG97812.1 - 0.00092 19.1 0.0 0.034 14.0 0.0 2.3 1 1 1 2 2 2 1 short chain dehydrogenase Peptidase_C47 PF05543.8 KOG97812.1 - 0.029 13.8 0.2 0.33 10.3 0.0 2.2 2 0 0 2 2 2 0 Staphopain peptidase C47 Apc9 PF12856.2 KOG97813.1 - 1.4e-19 69.9 0.1 2.6e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 9 CDC45 PF02724.9 KOG97814.1 - 1.3e-218 727.0 0.3 1.5e-218 726.8 0.2 1.0 1 0 0 1 1 1 1 CDC45-like protein MGDG_synth PF06925.6 KOG97814.1 - 0.14 12.0 0.1 0.38 10.6 0.1 1.8 1 0 0 1 1 1 0 Monogalactosyldiacylglycerol (MGDG) synthase DUF2201_N PF13203.1 KOG97814.1 - 0.17 10.9 2.6 0.27 10.3 1.8 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain IFT57 PF10498.4 KOG97814.1 - 1.6 7.3 12.0 0.065 11.9 3.6 1.8 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Sigma70_ner PF04546.8 KOG97814.1 - 1.9 8.0 16.6 2.5 7.6 8.4 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region tRNA_int_endo PF01974.12 KOG97816.1 - 4.6e-23 80.8 0.2 8.7e-23 79.9 0.1 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.9 KOG97816.1 - 0.0026 17.2 0.0 0.097 12.2 0.0 2.5 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain Atg14 PF10186.4 KOG97816.1 - 0.083 11.8 2.9 0.11 11.3 2.0 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 NMDAR2_C PF10565.4 KOG97816.1 - 0.82 8.2 2.9 1.1 7.8 2.0 1.1 1 0 0 1 1 1 0 N-methyl D-aspartate receptor 2B3 C-terminus AAA_5 PF07728.9 KOG97817.1 - 5.6e-127 418.1 1.1 4.8e-21 74.9 0.0 9.5 8 1 1 9 9 9 9 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 KOG97817.1 - 7.1e-32 109.7 0.0 1.9e-10 40.4 0.0 8.2 8 0 0 8 8 8 4 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 KOG97817.1 - 9.6e-27 93.7 0.7 0.00028 21.0 0.0 8.0 7 0 0 7 7 7 4 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOG97817.1 - 8.4e-21 75.0 24.9 0.0066 17.2 0.0 9.2 9 0 0 9 9 6 6 AAA domain Sigma54_activ_2 PF14532.1 KOG97817.1 - 2.3e-20 73.0 0.2 0.0021 18.1 0.0 7.5 8 0 0 8 8 6 3 Sigma-54 interaction domain AAA_16 PF13191.1 KOG97817.1 - 2.2e-18 66.9 11.2 0.0013 18.7 0.1 8.6 7 2 0 7 7 6 4 AAA ATPase domain Sigma54_activat PF00158.21 KOG97817.1 - 2.6e-18 66.0 0.1 0.0041 16.5 0.0 5.9 6 0 0 6 6 5 4 Sigma-54 interaction domain AAA_22 PF13401.1 KOG97817.1 - 9.7e-18 64.5 3.5 0.029 14.4 0.7 8.3 6 2 0 6 6 6 3 AAA domain AAA_14 PF13173.1 KOG97817.1 - 1.4e-17 63.8 8.2 0.00025 20.9 0.0 9.2 9 1 0 9 9 7 5 AAA domain AAA_33 PF13671.1 KOG97817.1 - 1.3e-15 57.4 0.2 0.018 14.9 0.5 7.4 6 2 0 6 6 6 2 AAA domain T2SE PF00437.15 KOG97817.1 - 2.9e-15 55.9 6.4 0.011 14.6 0.0 6.3 6 0 0 6 6 6 4 Type II/IV secretion system protein RNA_helicase PF00910.17 KOG97817.1 - 3.9e-13 49.5 1.2 0.057 13.5 0.0 7.2 7 0 0 7 7 6 2 RNA helicase UPF0079 PF02367.12 KOG97817.1 - 7e-13 48.2 3.9 0.13 11.9 0.0 7.0 7 0 0 7 7 7 3 Uncharacterised P-loop hydrolase UPF0079 MobB PF03205.9 KOG97817.1 - 2.5e-12 46.6 2.5 0.062 13.0 0.1 7.0 6 0 0 6 6 6 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 KOG97817.1 - 6.6e-11 41.8 3.8 0.75 9.5 0.0 6.4 6 0 0 6 6 6 3 Part of AAA domain Miro PF08477.8 KOG97817.1 - 7.7e-11 42.5 3.9 0.3 11.5 0.0 7.4 7 0 0 7 7 5 2 Miro-like protein Mg_chelatase PF01078.16 KOG97817.1 - 1.4e-10 40.7 0.6 1.8 7.6 0.0 8.6 10 0 0 10 10 9 2 Magnesium chelatase, subunit ChlI DUF258 PF03193.11 KOG97817.1 - 2.6e-10 39.7 8.8 0.032 13.4 0.0 5.7 6 0 0 6 6 6 3 Protein of unknown function, DUF258 ABC_tran PF00005.22 KOG97817.1 - 2.7e-10 40.6 35.9 0.00085 19.6 0.0 8.4 8 1 0 8 8 6 4 ABC transporter PduV-EutP PF10662.4 KOG97817.1 - 4.4e-10 39.2 3.7 0.031 13.7 0.1 6.0 6 0 0 6 6 6 2 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.1 KOG97817.1 - 9.5e-10 38.1 5.1 0.0098 15.3 0.1 5.7 6 0 0 6 6 5 2 AAA domain MMR_HSR1 PF01926.18 KOG97817.1 - 3.4e-09 36.6 2.4 2.9 7.8 0.0 7.0 6 0 0 6 6 6 1 50S ribosome-binding GTPase AAA_29 PF13555.1 KOG97817.1 - 7.1e-09 35.0 2.8 0.68 9.4 0.0 6.6 6 0 0 6 6 6 1 P-loop containing region of AAA domain AAA_28 PF13521.1 KOG97817.1 - 9.7e-09 35.3 6.2 2.5 8.0 0.1 6.8 6 0 0 6 6 6 2 AAA domain NACHT PF05729.7 KOG97817.1 - 1.8e-08 34.2 8.5 0.13 11.9 0.2 6.3 6 0 0 6 6 6 2 NACHT domain SRP54 PF00448.17 KOG97817.1 - 6.6e-08 32.2 6.3 0.15 11.4 0.4 5.8 6 0 0 6 6 5 2 SRP54-type protein, GTPase domain IstB_IS21 PF01695.12 KOG97817.1 - 8.7e-08 31.7 0.5 1.2 8.5 0.0 5.5 6 0 0 6 6 6 1 IstB-like ATP binding protein AAA_18 PF13238.1 KOG97817.1 - 1.7e-07 31.5 51.9 0.0077 16.5 0.0 11.6 11 1 0 11 11 8 4 AAA domain ATP-synt_ab PF00006.20 KOG97817.1 - 2.1e-06 27.4 0.0 1 8.7 0.0 3.7 3 1 0 3 3 3 2 ATP synthase alpha/beta family, nucleotide-binding domain PhoH PF02562.11 KOG97817.1 - 3e-06 26.6 0.9 3.5 6.8 0.0 5.2 5 0 0 5 5 5 2 PhoH-like protein RuvB_N PF05496.7 KOG97817.1 - 3.8e-06 26.1 1.4 0.32 9.9 0.0 4.8 6 0 0 6 6 6 1 Holliday junction DNA helicase ruvB N-terminus AAA_7 PF12775.2 KOG97817.1 - 3.9e-06 26.1 1.5 0.52 9.3 0.0 4.2 4 0 0 4 4 4 2 P-loop containing dynein motor region D3 KaiC PF06745.8 KOG97817.1 - 0.0001 21.4 0.8 1.6 7.7 0.0 4.3 4 0 0 4 4 4 2 KaiC AAA_6 PF12774.2 KOG97817.1 - 0.00062 19.3 0.0 21 4.5 0.0 5.4 6 0 0 6 6 6 0 Hydrolytic ATP binding site of dynein motor region D1 NTPase_1 PF03266.10 KOG97817.1 - 0.0039 16.9 13.0 3.2 7.4 0.5 6.7 8 0 0 8 8 6 1 NTPase AAA_23 PF13476.1 KOG97817.1 - 0.59 10.4 0.0 0.59 10.4 0.0 12.8 9 2 2 12 12 6 0 AAA domain RNase_T PF00929.19 KOG97818.1 - 7.1e-20 71.9 0.1 1.4e-19 70.9 0.1 1.5 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 KOG97818.1 - 0.0044 16.5 1.8 0.011 15.2 0.1 2.4 2 1 0 2 2 2 1 3'-5' exonuclease DUF1818 PF08848.6 KOG97818.1 - 0.02 14.9 0.1 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1818) BTB_2 PF02214.17 KOG97820.1 - 1.2e-06 28.5 3.8 0.0091 16.1 0.1 3.0 2 1 0 2 2 2 2 BTB/POZ domain SLS PF14611.1 KOG97820.1 - 0.0043 16.4 0.0 0.0083 15.5 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator Redoxin PF08534.5 KOG97821.1 - 3e-32 111.1 0.2 3.3e-32 111.0 0.2 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 KOG97821.1 - 1.6e-08 34.2 0.1 2.1e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Alkyl_sulf_C PF14864.1 KOG97821.1 - 0.031 14.2 0.0 0.058 13.3 0.0 1.4 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal Flocculin_t3 PF13928.1 KOG97822.1 - 1.2e-15 57.3 19.8 1.2e-15 57.3 13.7 2.6 3 0 0 3 3 3 1 Flocculin type 3 repeat Pkinase PF00069.20 KOG97823.1 - 3.5e-70 236.1 0.0 4.6e-70 235.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97823.1 - 1.5e-30 106.1 0.0 2.2e-30 105.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOG97823.1 - 1.6e-05 24.0 0.1 5.4e-05 22.3 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG97823.1 - 0.00028 20.7 0.6 0.0018 18.0 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOG97823.1 - 0.0026 16.7 0.0 0.065 12.1 0.0 2.2 1 1 0 2 2 2 1 Kinase-like RIO1 PF01163.17 KOG97823.1 - 0.089 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Avl9 PF09794.4 KOG97824.1 - 2.1e-150 500.4 0.2 3.4e-150 499.7 0.2 1.3 1 0 0 1 1 1 1 Transport protein Avl9 DENN PF02141.16 KOG97824.1 - 9.3e-05 22.2 0.6 0.0017 18.1 0.4 2.3 1 1 0 1 1 1 1 DENN (AEX-3) domain DUF2347 PF09804.4 KOG97824.1 - 0.003 16.8 14.1 0.1 11.8 0.0 3.8 4 0 0 4 4 4 2 Uncharacterized conserved protein (DUF2347) SPA PF08616.5 KOG97824.1 - 0.0035 17.0 0.9 0.17 11.5 0.2 2.9 2 1 0 2 2 2 1 Stabilization of polarity axis CPSF100_C PF13299.1 KOG97825.1 - 3.1e-30 105.5 1.4 3.1e-30 105.5 1.0 3.4 2 2 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.3 KOG97825.1 - 2.5e-09 37.1 0.0 7.1e-09 35.6 0.0 1.8 1 0 0 1 1 1 1 Beta-Casp domain Rep_fac-A_3 PF08661.6 KOG97825.1 - 0.067 13.1 0.1 0.23 11.3 0.0 1.9 1 0 0 1 1 1 0 Replication factor A protein 3 TIR PF01582.15 KOG97825.1 - 0.21 10.9 3.0 0.11 11.9 0.1 1.9 2 0 0 2 2 2 0 TIR domain zf-CCHC PF00098.18 KOG97826.1 - 2.2e-06 27.3 8.7 1.2e-05 24.9 0.6 2.4 2 0 0 2 2 2 2 Zinc knuckle KH_1 PF00013.24 KOG97826.1 - 1.6e-05 24.4 0.0 4.7e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 KH domain zf-CCHC_3 PF13917.1 KOG97826.1 - 2.3e-05 24.0 0.7 0.008 15.8 0.1 2.5 2 0 0 2 2 2 2 Zinc knuckle KH_3 PF13014.1 KOG97826.1 - 2.4e-05 23.8 0.0 5.3e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 KH domain Prim_Zn_Ribbon PF08273.7 KOG97826.1 - 0.084 12.9 3.3 0.17 11.9 2.3 1.5 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase bZIP_C PF12498.3 KOG97826.1 - 0.27 12.4 4.4 0.44 11.7 2.2 2.1 2 1 0 2 2 2 0 Basic leucine-zipper C terminal zf-CCHC_2 PF13696.1 KOG97826.1 - 1 8.8 8.0 0.2 11.1 0.4 2.9 1 1 1 2 2 2 0 Zinc knuckle DUF605 PF04652.11 KOG97826.1 - 8.3 5.6 16.1 0.87 8.9 7.3 1.9 2 0 0 2 2 2 0 Vta1 like HAT PF02184.11 KOG97827.1 - 4.6e-20 71.0 41.1 3.7e-10 39.3 0.7 8.7 9 0 0 9 9 8 5 HAT (Half-A-TPR) repeat TPR_14 PF13428.1 KOG97827.1 - 3.5e-16 58.2 0.0 1 10.1 0.0 8.8 5 2 4 9 9 8 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOG97827.1 - 9.4e-09 35.7 0.0 0.16 12.6 0.0 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOG97827.1 - 6.8e-06 25.6 1.9 3.6 7.3 0.0 6.0 7 1 1 8 8 8 1 TPR repeat TPR_19 PF14559.1 KOG97827.1 - 6.8e-06 26.3 0.0 2.1 8.7 0.0 4.6 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOG97827.1 - 2.6e-05 24.0 0.0 0.084 13.1 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOG97827.1 - 0.00019 21.2 3.6 1.5 8.7 0.2 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat Suf PF05843.9 KOG97827.1 - 0.00068 19.4 22.7 0.076 12.7 0.1 5.5 3 2 1 4 4 4 2 Suppressor of forked protein (Suf) TPR_2 PF07719.12 KOG97827.1 - 0.002 17.8 17.6 1.5 8.9 0.1 7.8 10 0 0 10 10 10 2 Tetratricopeptide repeat U3_assoc_6 PF08640.6 KOG97827.1 - 0.0054 16.4 2.1 0.0054 16.4 1.5 4.7 4 1 1 5 5 5 1 U3 small nucleolar RNA-associated protein 6 TPR_7 PF13176.1 KOG97827.1 - 0.01 15.5 6.6 4 7.4 0.1 5.1 4 1 1 5 5 5 0 Tetratricopeptide repeat NS3_envE PF02723.9 KOG97827.1 - 0.039 13.8 1.2 0.69 9.8 0.0 2.8 3 0 0 3 3 3 0 Non-structural protein NS3/Small envelope protein E TPR_1 PF00515.23 KOG97827.1 - 0.83 9.3 6.4 6.6 6.5 0.0 5.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOG97827.1 - 1.8 8.5 15.8 11 6.0 0.0 7.1 9 0 0 9 9 8 0 Tetratricopeptide repeat Abhydrolase_2 PF02230.11 KOG97828.1 - 3e-73 245.8 0.0 3.4e-73 245.6 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 KOG97828.1 - 1.2e-10 41.3 0.2 2.7e-10 40.1 0.2 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 KOG97828.1 - 1.8e-08 34.1 0.0 8.3e-08 31.9 0.0 1.9 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 KOG97828.1 - 3.3e-08 33.7 0.0 5.4e-07 29.7 0.0 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.13 KOG97828.1 - 1.2e-05 24.6 0.0 1.8e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.16 KOG97828.1 - 1.9e-05 23.9 0.0 0.0013 17.9 0.0 2.2 1 1 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.8 KOG97828.1 - 0.0053 16.3 0.0 0.0087 15.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.20 KOG97828.1 - 0.012 15.2 0.0 0.022 14.3 0.0 1.5 2 0 0 2 2 2 0 Lipase (class 3) DUF2920 PF11144.3 KOG97828.1 - 0.049 12.6 0.1 0.064 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Abhydrolase_1 PF00561.15 KOG97828.1 - 0.078 12.5 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.6 KOG97828.1 - 0.13 11.8 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Mod_r PF07200.8 KOG97829.1 - 6.1e-33 113.8 7.4 7.3e-33 113.5 5.1 1.0 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein GAS PF13851.1 KOG97829.1 - 3.2e-05 23.2 4.4 3.7e-05 23.0 3.0 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding T4SS PF07996.6 KOG97829.1 - 7.4e-05 22.6 0.3 0.00011 22.1 0.2 1.2 1 0 0 1 1 1 1 Type IV secretion system proteins TACC PF05010.9 KOG97829.1 - 0.00058 19.6 3.1 0.00082 19.1 2.1 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) BLOC1_2 PF10046.4 KOG97829.1 - 0.0012 18.9 2.3 0.25 11.5 0.2 2.5 2 1 0 2 2 2 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 Retrotrans_gag PF03732.12 KOG97829.1 - 0.0019 18.2 2.5 0.48 10.5 0.2 3.1 1 1 2 3 3 3 1 Retrotransposon gag protein IncA PF04156.9 KOG97829.1 - 0.0063 16.1 7.3 0.01 15.4 4.9 1.5 1 1 0 1 1 1 1 IncA protein DUF2959 PF11172.3 KOG97829.1 - 0.0085 15.8 2.2 0.01 15.5 1.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2959) MIS13 PF08202.6 KOG97829.1 - 0.015 14.3 0.7 0.022 13.8 0.5 1.2 1 0 0 1 1 1 0 Mis12-Mtw1 protein family TPR_MLP1_2 PF07926.7 KOG97829.1 - 0.045 13.4 4.0 0.17 11.6 2.8 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Occludin_ELL PF07303.8 KOG97829.1 - 0.05 14.3 6.7 0.4 11.4 1.3 2.2 1 1 1 2 2 2 0 Occludin homology domain Connexin50 PF03509.9 KOG97829.1 - 0.053 13.8 0.8 0.69 10.2 0.0 2.3 1 1 0 2 2 2 0 Gap junction alpha-8 protein (Cx50) Cep57_MT_bd PF06657.8 KOG97829.1 - 0.066 13.1 1.2 0.52 10.2 0.0 2.4 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DASH_Dad3 PF08656.5 KOG97829.1 - 0.067 12.8 0.8 0.7 9.6 0.0 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad3 TBPIP PF07106.8 KOG97829.1 - 0.074 12.6 4.8 0.14 11.6 0.2 2.1 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Phage_GP20 PF06810.6 KOG97829.1 - 0.086 12.2 3.0 0.13 11.7 2.1 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 Fzo_mitofusin PF04799.8 KOG97829.1 - 0.097 12.0 1.7 2.3 7.6 0.2 2.2 2 0 0 2 2 2 0 fzo-like conserved region Syntaxin-6_N PF09177.6 KOG97829.1 - 0.1 13.0 3.3 0.77 10.2 0.7 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DASH_Dam1 PF08653.5 KOG97829.1 - 0.1 12.3 0.5 0.92 9.3 0.1 2.3 2 0 0 2 2 2 0 DASH complex subunit Dam1 DivIC PF04977.10 KOG97829.1 - 0.11 12.0 1.0 2.3 7.7 0.1 2.4 2 0 0 2 2 2 0 Septum formation initiator Prefoldin_2 PF01920.15 KOG97829.1 - 0.17 11.6 4.4 0.72 9.6 3.1 2.0 1 1 0 1 1 1 0 Prefoldin subunit DASH_Dad2 PF08654.5 KOG97829.1 - 0.27 11.2 1.6 7.2 6.6 0.0 2.3 1 1 0 2 2 2 0 DASH complex subunit Dad2 APG6 PF04111.7 KOG97829.1 - 0.41 9.6 6.6 0.52 9.3 4.1 1.4 1 1 0 1 1 1 0 Autophagy protein Apg6 Seryl_tRNA_N PF02403.17 KOG97829.1 - 0.69 9.9 4.8 3.5 7.6 0.2 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF904 PF06005.7 KOG97829.1 - 2.8 8.2 6.7 1.1e+02 3.1 4.7 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF904) DUF342 PF03961.8 KOG97829.1 - 3.3 6.0 5.6 1.3 7.3 0.3 1.8 1 1 2 3 3 3 0 Protein of unknown function (DUF342) Asp PF00026.18 KOG97830.1 - 1.6e-75 254.3 12.1 1.4e-65 221.6 4.1 2.3 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOG97830.1 - 8.4e-06 25.8 10.0 0.0044 16.9 0.1 3.3 3 0 0 3 3 3 2 Xylanase inhibitor N-terminal TAXi_C PF14541.1 KOG97830.1 - 0.0033 16.9 0.1 0.062 12.8 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal RVP PF00077.15 KOG97830.1 - 0.012 15.5 0.0 4.3 7.3 0.0 2.8 2 1 0 2 2 2 0 Retroviral aspartyl protease Asp PF00026.18 KOG97831.1 - 1.6e-71 241.1 3.4 1.6e-71 241.1 2.3 1.5 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOG97831.1 - 2.9e-09 37.0 1.4 2.9e-09 37.0 1.0 3.4 3 1 0 3 3 3 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 KOG97831.1 - 0.00017 21.1 0.5 0.0014 18.1 0.3 2.2 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal DUF3449 PF11931.3 KOG97832.1 - 0.046 13.2 1.5 0.055 12.9 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) RSF PF14876.1 KOG97832.1 - 0.063 12.0 0.0 0.1 11.4 0.0 1.3 1 1 0 1 1 1 0 Respiratory growth transcriptional regulator DUF4355 PF14265.1 KOG97832.1 - 0.074 13.0 7.0 0.1 12.5 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) Spore_coat_CotO PF14153.1 KOG97832.1 - 0.56 9.6 5.0 0.61 9.5 3.5 1.1 1 0 0 1 1 1 0 Spore coat protein CotO GATase PF00117.23 KOG97833.1 - 6.1e-13 48.6 0.0 7.5e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 KOG97833.1 - 0.011 15.1 0.0 0.028 13.8 0.0 1.7 1 1 0 1 1 1 0 Peptidase C26 Cullin PF00888.17 KOG97834.1 - 1.2e-41 142.9 6.4 1.2e-41 142.9 4.4 2.5 3 0 0 3 3 3 1 Cullin family APC2 PF08672.6 KOG97834.1 - 3.2e-19 68.9 0.1 1.4e-18 66.9 0.1 2.2 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 FeoC PF09012.5 KOG97834.1 - 0.0026 17.4 0.0 0.027 14.1 0.0 2.5 3 0 0 3 3 3 1 FeoC like transcriptional regulator DUF2274 PF10038.4 KOG97834.1 - 0.028 14.5 0.0 0.07 13.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2274) POLO_box PF00659.13 KOG97834.1 - 0.036 14.0 1.8 0.15 12.0 0.0 3.0 4 0 0 4 4 4 0 POLO box duplicated region Cullin_binding PF03556.10 KOG97835.1 - 2.5e-32 111.4 4.6 2.8e-32 111.3 2.3 1.7 2 0 0 2 2 2 1 Cullin binding UBA_4 PF14555.1 KOG97835.1 - 4.4e-11 42.1 0.0 3.1e-10 39.4 0.0 2.2 2 0 0 2 2 2 1 UBA-like domain TAP_C PF03943.8 KOG97835.1 - 0.076 12.4 0.1 0.25 10.8 0.0 1.9 2 0 0 2 2 2 0 TAP C-terminal domain WD40 PF00400.27 KOG97836.1 - 7.4e-73 238.0 26.5 1.5e-10 40.5 0.3 11.0 11 0 0 11 11 11 10 WD domain, G-beta repeat Utp12 PF04003.7 KOG97836.1 - 7.5e-22 77.3 0.5 1.4e-21 76.4 0.3 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family Nup160 PF11715.3 KOG97836.1 - 4.4e-09 35.0 12.5 0.00021 19.5 0.1 5.5 4 2 2 6 6 6 3 Nucleoporin Nup120/160 eIF2A PF08662.6 KOG97836.1 - 0.00022 20.9 2.0 0.12 12.0 0.0 4.3 3 2 2 5 5 5 1 Eukaryotic translation initiation factor eIF2A Glu_cyclase_2 PF05096.7 KOG97836.1 - 0.0038 16.2 1.5 0.16 10.9 0.1 2.9 3 0 0 3 3 3 1 Glutamine cyclotransferase Hira PF07569.6 KOG97836.1 - 0.0088 15.2 6.3 2.5 7.2 0.0 5.5 6 1 1 7 7 7 1 TUP1-like enhancer of split Zip PF02535.17 KOG97837.1 - 1.9e-66 224.2 3.6 2.8e-66 223.7 2.5 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter UNC-50 PF05216.8 KOG97837.1 - 0.032 13.4 1.0 0.09 11.9 0.5 1.8 2 0 0 2 2 2 0 UNC-50 family zf-C2H2 PF00096.21 KOG97838.1 - 4.8e-07 29.7 12.0 0.0021 18.3 0.9 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG97838.1 - 0.00053 20.1 9.9 0.055 13.8 0.8 4.3 4 0 0 4 4 4 1 C2H2-type zinc finger Bunya_G2 PF03563.8 KOG97838.1 - 0.0069 15.3 0.3 0.01 14.7 0.2 1.1 1 0 0 1 1 1 1 Bunyavirus glycoprotein G2 zf-H2C2_2 PF13465.1 KOG97838.1 - 0.0099 16.1 13.2 0.84 10.0 0.0 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_6 PF13912.1 KOG97838.1 - 0.026 14.4 3.4 0.32 10.9 0.0 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger DUF3582 PF12122.3 KOG97838.1 - 0.044 13.7 0.3 0.044 13.7 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3582) zf-C2H2_jaz PF12171.3 KOG97838.1 - 0.053 13.6 0.4 11 6.3 0.1 3.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF641 PF04859.7 KOG97838.1 - 1.5 8.5 8.3 3.4 7.4 5.7 1.6 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) HVSL PF09749.4 KOG97839.1 - 1.6e-35 122.2 0.2 2e-35 121.9 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein Choline_kinase PF01633.15 KOG97840.1 - 5.3e-72 241.8 0.2 7.2e-72 241.3 0.2 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.9 KOG97840.1 - 1.9e-15 56.0 0.9 4.7e-15 54.7 0.1 2.1 2 0 0 2 2 2 1 Choline kinase N terminus APH PF01636.18 KOG97840.1 - 1.5e-09 37.9 0.0 0.00014 21.6 0.0 2.9 2 1 0 2 2 2 2 Phosphotransferase enzyme family TPP_enzyme_M PF00205.17 KOG97841.1 - 1.3e-36 125.3 0.0 5.6e-36 123.3 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N PF02776.13 KOG97841.1 - 1.4e-33 115.8 0.0 2.5e-33 114.9 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 KOG97841.1 - 8.2e-16 57.9 0.0 1.6e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.11 KOG97841.1 - 0.00041 19.9 0.3 0.0011 18.6 0.0 1.8 2 0 0 2 2 2 1 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit E1_dh PF00676.15 KOG97841.1 - 0.07 11.8 0.0 0.14 10.9 0.0 1.4 1 0 0 1 1 1 0 Dehydrogenase E1 component OCC1 PF15506.1 KOG97841.1 - 0.14 12.0 0.5 3.3 7.6 0.1 2.5 2 0 0 2 2 2 0 OCC1 family Slx4 PF09494.5 KOG97842.1 - 4.1e-17 61.6 0.7 1.1e-15 57.0 0.1 2.5 2 0 0 2 2 2 2 Slx4 endonuclease zf-CCCH PF00642.19 KOG97843.1 - 1.3e-17 62.9 19.8 3.9e-10 39.1 1.4 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 KOG97843.1 - 0.095 12.7 15.8 0.15 12.0 0.5 3.0 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type Methyltransf_16 PF10294.4 KOG97844.1 - 2.9e-06 26.8 0.0 0.01 15.3 0.0 2.3 2 0 0 2 2 2 2 Putative methyltransferase Nha1_C PF08619.5 KOG97845.1 - 1.7e-93 314.3 41.4 3.9e-93 313.1 28.7 1.6 1 1 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.16 KOG97845.1 - 4.2e-80 269.0 26.3 5.1e-80 268.8 18.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family SLS PF14611.1 KOG97846.1 - 3.6e-34 118.0 1.7 7.6e-34 116.9 1.2 1.6 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator DUF2945 PF11160.3 KOG97847.1 - 0.13 12.0 0.9 0.43 10.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2945) Pro_dh PF01619.13 KOG97848.1 - 1.7e-77 260.4 0.0 2.2e-77 260.1 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase ATP_bind_4 PF01902.12 KOG97849.1 - 5.3e-35 120.7 0.0 6.2e-34 117.2 0.0 2.5 1 1 0 1 1 1 1 ATP-binding region Ribonuc_L-PSP PF01042.16 KOG97849.1 - 3.2e-19 68.8 0.0 5.9e-11 42.1 0.0 2.3 2 0 0 2 2 2 2 Endoribonuclease L-PSP CENP-Q PF13094.1 KOG97849.1 - 0.03 14.3 2.2 0.044 13.8 0.2 2.2 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit QueC PF06508.8 KOG97849.1 - 0.1 11.8 1.0 1 8.5 0.0 2.4 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC Glyco_hydro_81 PF03639.8 KOG97851.1 - 9.5e-291 965.8 13.7 1.1e-290 965.6 9.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 Spermine_synth PF01564.12 KOG97853.1 - 3.6e-92 307.7 0.0 7.6e-92 306.6 0.0 1.4 2 0 0 2 2 2 1 Spermine/spermidine synthase Methyltransf_18 PF12847.2 KOG97853.1 - 6.3e-07 29.9 0.0 1e-06 29.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOG97853.1 - 1.9e-05 24.4 0.0 5.7e-05 22.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOG97853.1 - 0.00018 21.1 0.0 0.00028 20.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOG97853.1 - 0.00093 19.6 0.0 0.0022 18.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOG97853.1 - 0.0015 18.5 0.0 0.003 17.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.12 KOG97853.1 - 0.0019 17.2 0.0 0.0028 16.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase CMAS PF02353.15 KOG97853.1 - 0.074 12.1 0.0 0.25 10.4 0.0 1.8 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.9 KOG97853.1 - 0.12 11.7 0.0 0.32 10.3 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase small domain Laminin_I PF06008.9 KOG97854.1 - 0.0043 16.4 1.7 0.0047 16.2 1.2 1.1 1 0 0 1 1 1 1 Laminin Domain I Eno-Rase_FAD_bd PF07055.7 KOG97854.1 - 0.019 14.9 0.5 0.024 14.5 0.4 1.2 1 0 0 1 1 1 0 Enoyl reductase FAD binding domain GP41 PF00517.12 KOG97854.1 - 0.085 12.4 2.3 0.085 12.4 1.6 1.0 1 0 0 1 1 1 0 Retroviral envelope protein DUF2968 PF11180.3 KOG97854.1 - 0.27 10.5 3.4 0.28 10.5 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Syntaxin PF00804.20 KOG97854.1 - 0.31 11.2 3.6 0.59 10.3 2.5 1.5 1 1 0 1 1 1 0 Syntaxin LSM PF01423.17 KOG97855.1 - 2e-14 52.8 0.1 2.6e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain Pep3_Vps18 PF05131.9 KOG97856.1 - 3.4e-42 143.3 0.1 9e-42 141.9 0.1 1.8 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.15 KOG97856.1 - 3.3e-16 59.1 7.7 3.3e-16 59.1 5.3 4.4 5 0 0 5 5 5 2 Region in Clathrin and VPS Vps39_2 PF10367.4 KOG97856.1 - 7.6e-05 22.8 2.4 0.00015 21.8 0.2 2.4 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 zf-RING_2 PF13639.1 KOG97856.1 - 0.00011 21.9 3.3 0.00022 20.9 2.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KOG97856.1 - 0.0043 16.7 2.7 0.0094 15.6 1.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOG97856.1 - 0.063 12.9 0.9 0.13 11.9 0.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) YhdB PF14148.1 KOG97856.1 - 0.063 13.0 4.9 0.76 9.5 0.0 3.5 3 0 0 3 3 3 0 YhdB-like protein zf-C3HC4_2 PF13923.1 KOG97856.1 - 0.46 10.5 8.4 0.027 14.5 2.1 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF2415 PF10313.4 KOG97857.1 - 2.6e-20 71.8 1.3 5.4e-20 70.8 0.9 1.6 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) Stm1_N PF09598.5 KOG97858.1 - 3.8e-18 65.9 2.4 3.8e-18 65.9 1.7 4.5 5 1 0 5 5 5 1 Stm1 NUDIX PF00293.23 KOG97859.1 - 6.2e-19 67.9 0.0 9.8e-19 67.3 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Mem_trans PF03547.13 KOG97860.1 - 1.2e-51 175.2 0.0 2.6e-51 174.1 0.0 1.6 1 1 0 1 1 1 1 Membrane transport protein Reticulon PF02453.12 KOG97860.1 - 0.65 9.5 13.0 0.14 11.7 1.6 2.9 2 1 0 2 2 2 0 Reticulon AMP-binding PF00501.23 KOG97861.1 - 1.4e-88 297.0 0.1 1.9e-88 296.6 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 KOG97861.1 - 8.3e-19 68.3 0.0 2.3e-18 66.9 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RNase_H2_suC PF08615.6 KOG97862.1 - 0.14 12.0 0.2 0.99 9.2 0.2 2.2 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Peptidase_M16 PF00675.15 KOG97864.1 - 2.6e-52 176.5 0.0 4.6e-52 175.7 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 KOG97864.1 - 1.8e-38 132.0 0.0 8.7e-38 129.8 0.0 2.0 2 0 0 2 2 2 1 Peptidase M16 inactive domain CybS PF05328.7 KOG97865.1 - 6.1e-46 155.3 0.1 7.2e-46 155.1 0.0 1.1 1 0 0 1 1 1 1 CybS PseudoU_synth_2 PF00849.17 KOG97866.1 - 1.4e-21 77.0 0.3 2e-21 76.5 0.2 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Sec10 PF07393.6 KOG97867.1 - 3.5e-207 689.9 31.1 4.5e-207 689.5 21.6 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 RTBV_P12 PF06361.6 KOG97867.1 - 0.021 15.0 0.8 0.21 11.8 0.3 2.6 2 1 1 3 3 3 0 Rice tungro bacilliform virus P12 protein Endonuc-dimeris PF09124.5 KOG97867.1 - 0.036 13.6 1.6 8.4 6.1 0.0 2.9 2 0 0 2 2 2 0 T4 recombination endonuclease VII, dimerisation ubiquitin PF00240.18 KOG97868.1 - 1.5e-34 117.2 0.9 2.7e-34 116.3 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.14 KOG97868.1 - 2.5e-27 94.4 1.7 4.5e-27 93.6 1.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.3 KOG97868.1 - 5.1e-20 70.9 0.7 1e-19 69.9 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 KOG97868.1 - 8.8e-06 25.8 0.2 3.9e-05 23.8 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 KOG97868.1 - 0.00012 21.8 0.0 0.00018 21.2 0.0 1.2 1 0 0 1 1 1 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 KOG97868.1 - 0.0013 18.5 0.3 0.0029 17.4 0.2 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 KOG97868.1 - 0.0057 16.8 0.5 0.0075 16.4 0.4 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain IBR PF01485.16 KOG97868.1 - 0.016 15.0 0.4 0.023 14.5 0.2 1.3 1 0 0 1 1 1 0 IBR domain Fer2_3 PF13085.1 KOG97868.1 - 0.042 13.6 0.3 0.083 12.7 0.1 1.6 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain DUF2870 PF11069.3 KOG97868.1 - 0.059 13.4 0.2 0.13 12.3 0.1 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2870) Plexin_cytopl PF08337.7 KOG97868.1 - 0.21 9.8 2.3 5.4 5.1 0.1 2.1 1 1 1 2 2 2 0 Plexin cytoplasmic RasGAP domain PRELI PF04707.9 KOG97869.1 - 8.6e-61 204.1 0.7 1.2e-60 203.6 0.5 1.2 1 0 0 1 1 1 1 PRELI-like family GalP_UDP_tr_C PF02744.12 KOG97869.1 - 0.026 14.0 0.2 0.11 12.0 0.0 1.8 2 0 0 2 2 2 0 Galactose-1-phosphate uridyl transferase, C-terminal domain Clat_adaptor_s PF01217.15 KOG97870.1 - 3.5e-59 198.6 2.9 4e-59 198.4 2.0 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TP_methylase PF00590.15 KOG97871.1 - 2.4e-25 89.4 0.0 3.7e-25 88.8 0.0 1.3 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF4434 PF14488.1 KOG97871.1 - 0.01 15.5 0.1 0.028 14.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4434) Iso_dh PF00180.15 KOG97873.1 - 1.1e-70 238.3 0.0 1.3e-70 238.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase YfmQ PF10787.4 KOG97873.1 - 0.035 13.4 0.0 0.081 12.2 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein from bacillus cereus group DUF4355 PF14265.1 KOG97873.1 - 0.046 13.6 0.6 0.1 12.5 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) DUF2543 PF10820.3 KOG97873.1 - 0.097 12.6 0.2 0.22 11.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2543) DKCLD PF08068.7 KOG97874.1 - 2.9e-30 103.9 0.1 1.3e-29 101.8 0.1 2.2 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.13 KOG97874.1 - 2.2e-21 76.5 6.9 3.4e-20 72.7 0.0 3.8 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 KOG97874.1 - 4.8e-19 67.8 1.0 9.7e-19 66.8 0.7 1.6 1 0 0 1 1 1 1 PUA domain GAGA_bind PF06217.7 KOG97874.1 - 0.02 14.8 22.2 0.029 14.3 15.4 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family RFX_DNA_binding PF02257.10 KOG97875.1 - 8.5e-35 118.7 0.5 2.4e-34 117.3 0.1 2.0 2 0 0 2 2 2 1 RFX DNA-binding domain Pox_D5 PF03288.11 KOG97875.1 - 0.01 16.1 0.0 0.028 14.6 0.0 1.7 1 0 0 1 1 1 0 Poxvirus D5 protein-like PSP1 PF04468.7 KOG97876.1 - 1.5e-36 124.2 0.2 3.1e-36 123.2 0.1 1.6 1 0 0 1 1 1 1 PSP1 C-terminal conserved region PBP PF01161.15 KOG97877.1 - 3.7e-34 117.6 0.6 4.9e-34 117.2 0.4 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF3260 PF11658.3 KOG97877.1 - 0.08 11.0 0.1 0.1 10.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) PBP PF01161.15 KOG97878.1 - 2.5e-30 105.2 0.0 3.1e-30 104.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein S-AdoMet_synt_C PF02773.11 KOG97879.1 - 1.9e-74 247.9 0.1 3e-74 247.2 0.1 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 KOG97879.1 - 1.9e-47 160.1 0.0 3.6e-47 159.2 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 KOG97879.1 - 6.3e-45 151.4 0.1 1.2e-44 150.5 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain DUF605 PF04652.11 KOG97880.1 - 7.8e-59 199.9 6.7 2e-41 142.6 0.9 2.0 1 1 1 2 2 2 2 Vta1 like DUF4041 PF13250.1 KOG97880.1 - 0.016 14.7 5.5 2.9 7.5 0.0 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4041) Ank PF00023.25 KOG97881.1 - 6e-13 47.8 1.6 2.9e-06 26.7 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOG97881.1 - 1.2e-12 47.6 2.6 8.8e-07 28.9 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOG97881.1 - 2.3e-12 47.0 0.1 1.9e-07 31.3 0.1 2.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOG97881.1 - 3.4e-12 45.3 1.5 1.5e-05 24.7 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOG97881.1 - 1.6e-08 34.7 2.0 0.0016 18.8 0.0 4.1 2 2 2 4 4 4 3 Ankyrin repeats (many copies) DUF3375 PF11855.3 KOG97881.1 - 0.0012 17.6 3.8 0.0028 16.4 2.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3375) DUF3508 PF12018.3 KOG97881.1 - 0.06 12.3 8.2 0.026 13.5 1.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3508) CHD5 PF04420.9 KOG97881.1 - 0.9 9.1 2.9 2.9 7.5 2.0 1.8 1 0 0 1 1 1 0 CHD5-like protein COG5 PF10392.4 KOG97881.1 - 6.7 6.6 19.3 1.2 9.0 4.3 4.0 4 0 0 4 4 4 0 Golgi transport complex subunit 5 FHA PF00498.21 KOG97882.1 - 2.3e-07 30.8 0.1 5.9e-07 29.5 0.1 1.7 1 0 0 1 1 1 1 FHA domain Erp_C PF06780.6 KOG97882.1 - 0.004 17.0 0.0 0.012 15.4 0.0 1.9 1 0 0 1 1 1 1 Erp protein C-terminus Ribosomal_L37e PF01907.14 KOG97883.1 - 7.3e-27 92.9 11.3 7.3e-27 92.9 7.8 1.5 2 0 0 2 2 2 1 Ribosomal protein L37e DZR PF12773.2 KOG97883.1 - 0.001 18.7 1.9 0.0015 18.2 1.3 1.2 1 0 0 1 1 1 1 Double zinc ribbon SelR PF01641.13 KOG97883.1 - 0.0023 17.6 0.4 0.0029 17.3 0.2 1.3 1 0 0 1 1 1 1 SelR domain zinc_ribbon_6 PF14599.1 KOG97883.1 - 0.015 15.1 2.4 0.021 14.6 1.6 1.2 1 0 0 1 1 1 0 Zinc-ribbon zf-Mss51 PF13824.1 KOG97883.1 - 0.084 12.7 0.8 0.12 12.2 0.5 1.3 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-ribbon_3 PF13248.1 KOG97883.1 - 0.085 12.0 3.8 0.24 10.6 2.6 1.7 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 KOG97883.1 - 0.088 12.3 2.7 1.5 8.3 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-RING_5 PF14634.1 KOG97883.1 - 0.1 12.3 3.1 0.16 11.7 2.1 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOG97883.1 - 0.17 11.6 2.6 0.23 11.1 1.8 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HypA PF01155.14 KOG97883.1 - 0.24 11.0 1.1 0.33 10.6 0.7 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family GATA PF00320.22 KOG97883.1 - 0.36 10.2 5.4 1.4 8.3 0.6 2.4 1 1 1 2 2 2 0 GATA zinc finger zf-C3HC4_2 PF13923.1 KOG97883.1 - 1 9.4 5.1 1.7 8.7 3.5 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOG97883.1 - 1.5 8.5 5.0 2.5 7.8 3.5 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) EMG1 PF03587.9 KOG97884.1 - 1.9e-76 255.8 0.0 2.2e-76 255.6 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase PH PF00169.24 KOG97885.1 - 1.8e-08 34.5 3.5 2.9e-07 30.6 0.1 3.1 3 1 0 3 3 3 2 PH domain ABC_membrane PF00664.18 KOG97886.1 - 2e-60 204.5 3.9 2.5e-60 204.2 2.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 KOG97886.1 - 7.7e-31 107.2 0.0 2.2e-30 105.7 0.0 1.8 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 KOG97886.1 - 1.9e-05 24.0 3.0 0.00029 20.1 0.4 2.5 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 KOG97886.1 - 3.2e-05 23.9 0.0 7.5e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 KOG97886.1 - 0.00028 21.0 0.0 0.0013 18.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.1 KOG97886.1 - 0.00029 20.8 0.0 0.23 11.3 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 KOG97886.1 - 0.00074 20.3 0.0 0.0017 19.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 KOG97886.1 - 0.0075 16.4 0.0 0.17 12.0 0.0 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF2391 PF09622.5 KOG97886.1 - 0.0079 15.3 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Putative integral membrane protein (DUF2391) AAA_14 PF13173.1 KOG97886.1 - 0.0087 15.9 0.0 0.13 12.1 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.1 KOG97886.1 - 0.012 15.1 0.0 0.03 13.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.9 KOG97886.1 - 0.014 15.0 0.0 0.35 10.5 0.0 2.7 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 KOG97886.1 - 0.019 15.2 0.0 0.27 11.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 KOG97886.1 - 0.02 14.7 0.0 0.24 11.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 KOG97886.1 - 0.02 14.0 0.0 0.074 12.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 SbcCD_C PF13558.1 KOG97886.1 - 0.05 13.5 0.5 0.24 11.3 0.3 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 KOG97886.1 - 0.052 12.9 0.0 0.35 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain DEAD PF00270.24 KOG97886.1 - 0.067 12.6 0.1 0.76 9.2 0.0 2.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_10 PF12846.2 KOG97886.1 - 0.073 12.4 0.1 0.46 9.8 0.0 2.3 3 0 0 3 3 3 0 AAA-like domain Zeta_toxin PF06414.7 KOG97886.1 - 0.1 11.6 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin PrgI PF12666.2 KOG97886.1 - 0.35 11.0 0.0 0.35 11.0 0.0 2.6 3 0 0 3 3 2 0 PrgI family protein Glyco_transf_28 PF03033.15 KOG97887.1 - 9.8e-30 103.1 0.0 2e-29 102.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain GRAM PF02893.15 KOG97887.1 - 3.9e-23 80.7 1.6 1.2e-17 63.1 0.5 2.9 2 0 0 2 2 2 2 GRAM domain UDPGT PF00201.13 KOG97887.1 - 3.5e-10 39.0 0.0 7.9e-10 37.8 0.0 1.6 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH PF00169.24 KOG97887.1 - 7.1e-09 35.8 2.3 7.1e-09 35.8 1.6 2.8 3 0 0 3 3 3 1 PH domain Glyco_trans_1_3 PF13528.1 KOG97887.1 - 0.0088 15.2 0.0 0.04 13.1 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 1 PH_11 PF15413.1 KOG97887.1 - 0.027 14.7 2.2 0.27 11.5 1.5 2.8 1 1 0 1 1 1 0 Pleckstrin homology domain Glyco_trans_4_4 PF13579.1 KOG97887.1 - 0.085 12.9 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain MMR1 PF08505.5 KOG97888.1 - 9.9e-64 215.5 9.8 9.9e-64 215.5 6.8 2.7 2 1 0 2 2 2 1 Mitochondrial Myo2 receptor-related protein Synaptonemal_3 PF15191.1 KOG97888.1 - 0.055 13.2 1.3 0.4 10.4 0.9 2.4 1 1 0 1 1 1 0 Synaptonemal complex central element protein 3 DUF573 PF04504.9 KOG97888.1 - 0.06 13.6 7.3 0.33 11.2 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function, DUF573 YlqD PF11068.3 KOG97888.1 - 2.5 8.1 16.0 0.9 9.5 3.4 2.4 2 0 0 2 2 2 0 YlqD protein Peroxin-13_N PF04088.8 KOG97889.1 - 9.6e-58 194.6 0.6 9.6e-58 194.6 0.4 1.5 2 0 0 2 2 2 1 Peroxin 13, N-terminal region SH3_1 PF00018.23 KOG97889.1 - 1.5e-09 37.1 0.1 2.7e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOG97889.1 - 4e-08 32.7 0.0 6.8e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOG97889.1 - 2e-07 30.3 0.2 4e-07 29.4 0.0 1.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.6 KOG97889.1 - 0.0033 17.5 0.1 0.0056 16.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain eIF3_subunit PF08597.5 KOG97890.1 - 5.5e-62 209.5 17.7 1.9e-61 207.7 12.3 1.7 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit PRELI PF04707.9 KOG97891.1 - 2.1e-50 170.3 0.0 2.5e-50 170.1 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family Serglycin PF04360.7 KOG97892.1 - 2.5 7.8 7.1 7.3 6.3 4.9 1.9 1 1 0 1 1 1 0 Serglycin NMT PF01233.14 KOG97893.1 - 1.6e-86 287.9 0.1 2.9e-86 287.0 0.1 1.5 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.10 KOG97893.1 - 3.2e-76 254.9 0.3 5.4e-76 254.2 0.2 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.1 KOG97893.1 - 2.4e-07 30.6 0.0 3.5e-05 23.6 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KOG97893.1 - 0.018 15.2 0.0 0.067 13.3 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain WD40 PF00400.27 KOG97894.1 - 1.7e-11 43.5 7.3 5.1e-06 26.1 0.4 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat Nup160 PF11715.3 KOG97894.1 - 0.0076 14.4 2.6 0.02 13.0 0.6 2.3 2 1 1 3 3 3 1 Nucleoporin Nup120/160 PQQ_3 PF13570.1 KOG97894.1 - 0.027 14.7 0.1 0.39 11.0 0.0 3.0 4 0 0 4 4 4 0 PQQ-like domain Nop PF01798.13 KOG97895.1 - 1.4e-60 202.9 0.1 2.5e-60 202.1 0.0 1.5 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 KOG97895.1 - 2.2e-26 91.3 0.1 4.6e-26 90.3 0.1 1.6 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 KOG97895.1 - 5.1e-23 81.0 0.5 5.1e-23 81.0 0.3 2.7 2 1 0 2 2 1 1 NOP5NT (NUC127) domain RNA_polI_A34 PF08208.6 KOG97895.1 - 0.023 14.3 49.4 0.038 13.6 34.3 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DDHD PF02862.12 KOG97895.1 - 0.27 11.0 11.0 0.46 10.2 7.6 1.5 1 0 0 1 1 1 0 DDHD domain GAGA_bind PF06217.7 KOG97895.1 - 0.39 10.6 19.1 0.59 10.0 13.2 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family PcfK PF14058.1 KOG97895.1 - 0.66 10.1 29.6 1.2 9.3 20.5 1.3 1 0 0 1 1 1 0 PcfK-like protein MIP-T3 PF10243.4 KOG97895.1 - 0.89 7.9 41.2 1.3 7.4 28.6 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 RNase_H2-Ydr279 PF09468.5 KOG97895.1 - 1.1 8.3 30.1 2.9 6.9 20.8 1.7 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) RR_TM4-6 PF06459.7 KOG97895.1 - 1.5 8.6 27.0 2.4 7.9 18.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.9 KOG97895.1 - 8 4.3 24.3 10 3.9 16.8 1.1 1 0 0 1 1 1 0 CDC45-like protein POC1 PF10450.4 KOG97896.1 - 9.7e-103 342.6 0.2 1.1e-102 342.5 0.1 1.0 1 0 0 1 1 1 1 POC1 chaperone Prefoldin_2 PF01920.15 KOG97897.1 - 2.4e-24 85.1 11.0 2.6e-24 85.0 7.6 1.0 1 0 0 1 1 1 1 Prefoldin subunit Spc24 PF08286.6 KOG97897.1 - 0.01 15.5 7.3 0.4 10.3 0.7 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF4201 PF13870.1 KOG97897.1 - 0.016 14.6 7.1 0.037 13.4 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) YgaB PF14182.1 KOG97897.1 - 0.039 14.1 6.9 0.082 13.1 0.5 2.2 2 0 0 2 2 2 0 YgaB-like protein CENP-F_leu_zip PF10473.4 KOG97897.1 - 0.055 13.3 9.7 0.82 9.5 0.7 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_27 PF13514.1 KOG97897.1 - 0.056 11.1 3.4 0.063 10.9 2.3 1.1 1 0 0 1 1 1 0 AAA domain T4_neck-protein PF11649.3 KOG97897.1 - 0.072 12.3 0.9 0.08 12.2 0.6 1.1 1 0 0 1 1 1 0 Virus neck protein Macoilin PF09726.4 KOG97897.1 - 0.079 11.2 4.4 0.095 10.9 3.0 1.0 1 0 0 1 1 1 0 Transmembrane protein ADIP PF11559.3 KOG97897.1 - 0.083 12.7 5.0 0.26 11.1 0.2 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Occludin_ELL PF07303.8 KOG97897.1 - 0.086 13.5 3.4 2.6 8.8 0.2 2.2 2 0 0 2 2 2 0 Occludin homology domain DUF2688 PF10892.3 KOG97897.1 - 0.1 12.3 0.2 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2688) FliD_N PF02465.13 KOG97897.1 - 0.11 12.8 0.1 12 6.3 0.0 2.2 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Bacillus_HBL PF05791.6 KOG97897.1 - 0.15 11.4 2.6 0.13 11.6 0.2 1.8 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Tup_N PF08581.5 KOG97897.1 - 0.19 11.9 5.9 0.62 10.2 0.1 2.7 2 1 1 3 3 3 0 Tup N-terminal Prefoldin_3 PF13758.1 KOG97897.1 - 0.25 11.1 4.9 9.6 6.0 3.3 2.5 1 1 0 1 1 1 0 Prefoldin subunit DUF1192 PF06698.6 KOG97897.1 - 0.25 11.1 4.7 0.16 11.8 0.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) DUF3166 PF11365.3 KOG97897.1 - 0.31 11.5 6.2 2 8.9 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3166) DUF641 PF04859.7 KOG97897.1 - 0.36 10.6 7.8 2 8.1 1.3 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) THOC7 PF05615.8 KOG97897.1 - 0.46 10.7 7.1 4.2 7.6 0.5 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 Tropomyosin_1 PF12718.2 KOG97897.1 - 0.51 10.1 12.2 3.5 7.4 8.4 2.0 1 1 0 1 1 1 0 Tropomyosin like DMPK_coil PF08826.5 KOG97897.1 - 0.95 9.4 12.7 0.56 10.1 2.7 2.6 2 2 0 2 2 2 0 DMPK coiled coil domain like Prefoldin PF02996.12 KOG97897.1 - 0.98 9.0 7.1 12 5.6 5.0 2.0 1 1 0 1 1 1 0 Prefoldin subunit DUF2046 PF09755.4 KOG97897.1 - 1 8.2 10.8 4.1 6.1 7.5 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Mnd1 PF03962.10 KOG97897.1 - 1 8.9 7.2 2.4 7.8 5.0 1.5 1 1 0 1 1 1 0 Mnd1 family IncA PF04156.9 KOG97897.1 - 1.1 8.8 11.9 2 7.9 8.2 1.4 1 1 0 1 1 1 0 IncA protein FliJ PF02050.11 KOG97897.1 - 1.9 8.5 9.8 6.8 6.7 1.6 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein DUF3847 PF12958.2 KOG97897.1 - 2.8 7.7 9.9 0.3 10.8 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) GAS PF13851.1 KOG97897.1 - 4 6.5 11.2 2.4 7.2 1.3 2.0 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Atg14 PF10186.4 KOG97897.1 - 4.1 6.2 7.4 6.2 5.6 5.1 1.3 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 GreA_GreB_N PF03449.10 KOG97897.1 - 5.7 7.0 8.7 13 5.9 0.1 3.4 2 2 2 4 4 4 0 Transcription elongation factor, N-terminal IFP_35_N PF07334.8 KOG97897.1 - 5.7 6.9 9.4 0.73 9.8 2.2 2.4 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Sugarporin_N PF11471.3 KOG97897.1 - 7.5 6.2 11.4 5.3 6.7 2.9 2.8 2 1 0 2 2 2 0 Maltoporin periplasmic N-terminal extension COQ9 PF08511.6 KOG97898.1 - 1.2e-18 66.3 0.7 1.2e-18 66.3 0.5 2.0 1 1 1 2 2 2 1 COQ9 zf-Mss51 PF13824.1 KOG97899.1 - 5.8e-18 64.5 0.8 1.1e-17 63.5 0.6 1.5 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 YL1_C PF08265.6 KOG97899.1 - 0.0083 15.6 0.0 0.025 14.1 0.0 1.8 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain DUF1713 PF08213.6 KOG97900.1 - 1.2e-12 47.1 24.7 1.7e-12 46.7 17.1 1.2 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) Atg14 PF10186.4 KOG97900.1 - 0.042 12.8 0.3 0.051 12.5 0.2 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Heme_oxygenase PF01126.15 KOG97901.1 - 1.1e-11 44.6 0.2 3.4e-11 43.1 0.2 1.8 1 1 0 1 1 1 1 Heme oxygenase ENTH PF01417.15 KOG97902.1 - 5.2e-42 142.6 1.4 1.2e-41 141.4 0.0 2.4 2 0 0 2 2 2 1 ENTH domain Herpes_LMP1 PF05297.6 KOG97902.1 - 6.6 5.5 7.8 11 4.8 5.4 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Sel1 PF08238.7 KOG97903.1 - 3.7e-21 75.0 9.5 4.8e-05 23.8 0.0 8.4 9 0 0 9 9 9 3 Sel1 repeat TPR_11 PF13414.1 KOG97903.1 - 5.6e-06 25.9 6.2 0.04 13.5 0.4 4.6 4 1 1 5 5 5 2 TPR repeat TPR_1 PF00515.23 KOG97903.1 - 7.1e-06 25.4 10.8 0.21 11.2 0.3 5.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOG97903.1 - 3.3e-05 23.4 10.9 0.28 11.1 0.4 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOG97903.1 - 3.5e-05 23.2 4.9 0.16 11.7 0.1 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOG97903.1 - 5e-05 22.8 8.9 0.045 13.5 0.1 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOG97903.1 - 0.0018 18.6 1.3 7.2 7.3 0.2 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOG97903.1 - 0.0028 17.5 6.3 5.1 7.1 0.6 5.0 4 1 0 4 4 4 2 Tetratricopeptide repeat WD40 PF00400.27 KOG97904.1 - 4.4e-44 146.8 20.0 4.6e-10 38.9 0.4 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIIIC_delta PF12657.2 KOG97904.1 - 0.00088 19.0 3.9 0.61 9.7 0.1 3.7 2 1 1 4 4 4 2 Transcription factor IIIC subunit delta N-term YmzC PF14157.1 KOG97904.1 - 0.033 13.9 0.1 9 6.2 0.0 3.3 4 0 0 4 4 4 0 YmzC-like protein PNP_UDP_1 PF01048.15 KOG97905.1 - 9.5e-42 142.5 0.0 1.1e-41 142.3 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Cyclin_N PF00134.18 KOG97906.1 - 7.4e-41 138.6 0.6 1.7e-40 137.5 0.4 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 KOG97906.1 - 1.3e-25 89.6 0.2 3.1e-25 88.3 0.0 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain Rootletin PF15035.1 KOG97907.1 - 0.00078 19.4 2.6 0.00089 19.2 1.8 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion DUF1640 PF07798.6 KOG97907.1 - 0.0073 16.3 1.6 0.01 15.8 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) bZIP_1 PF00170.16 KOG97907.1 - 0.021 14.7 1.0 0.021 14.7 0.7 2.3 2 0 0 2 2 2 0 bZIP transcription factor Nnf1 PF03980.9 KOG97907.1 - 0.043 13.7 4.9 0.13 12.3 0.8 2.8 1 1 1 2 2 2 0 Nnf1 Spectrin PF00435.16 KOG97907.1 - 0.05 13.8 2.6 0.096 12.9 1.8 1.4 1 0 0 1 1 1 0 Spectrin repeat DUF972 PF06156.8 KOG97907.1 - 0.37 11.1 3.8 0.6 10.4 1.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF972) IncA PF04156.9 KOG97907.1 - 1.3 8.6 3.4 1.7 8.1 2.4 1.2 1 0 0 1 1 1 0 IncA protein Tubulin PF00091.20 KOG97908.1 - 3.7e-69 232.8 0.0 6e-69 232.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KOG97908.1 - 6e-29 100.6 0.3 4.9e-28 97.6 0.1 2.4 3 0 0 3 3 3 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 KOG97908.1 - 0.00047 20.1 0.0 0.00099 19.1 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Glyco_hydro_16 PF00722.16 KOG97909.1 - 2.5e-47 160.5 0.2 4.8e-47 159.6 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 CFEM PF05730.6 KOG97910.1 - 0.0021 17.8 6.4 0.0033 17.1 4.4 1.3 1 0 0 1 1 1 1 CFEM domain CFEM PF05730.6 KOG97911.1 - 0.00047 19.9 6.1 0.00078 19.2 4.3 1.3 1 0 0 1 1 1 1 CFEM domain D123 PF07065.9 KOG97912.1 - 3.8e-110 367.6 2.1 4.7e-110 367.3 1.5 1.1 1 0 0 1 1 1 1 D123 Pro_isomerase PF00160.16 KOG97913.1 - 8.2e-44 149.5 0.2 1.5e-43 148.6 0.2 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.23 KOG97913.1 - 3.1e-06 26.5 1.4 7.6e-05 22.1 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOG97913.1 - 1.1e-05 24.9 3.3 0.015 14.9 0.3 2.5 2 1 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOG97913.1 - 0.00012 21.7 0.2 0.034 14.0 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3323 PF11796.3 KOG97913.1 - 0.44 9.8 2.9 0.19 11.0 0.6 1.4 2 0 0 2 2 2 0 Protein of unknown function N-terminus (DUF3323) VIT1 PF01988.14 KOG97915.1 - 1.9e-57 194.1 1.2 2.3e-57 193.9 0.9 1.1 1 0 0 1 1 1 1 VIT family DUF1517 PF07466.6 KOG97915.1 - 0.1 11.5 0.6 0.2 10.5 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) FAM176 PF14851.1 KOG97915.1 - 0.12 12.0 1.4 0.22 11.1 0.0 1.9 2 0 0 2 2 2 0 FAM176 family Rsa3 PF14615.1 KOG97916.1 - 4e-20 70.8 0.1 9.8e-20 69.5 0.1 1.7 1 0 0 1 1 1 1 Ribosome-assembly protein 3 SR-25 PF10500.4 KOG97916.1 - 0.23 10.9 24.0 0.065 12.6 14.7 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3827 PF12877.2 KOG97916.1 - 1.6 6.7 15.0 1.9 6.4 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Pap_E4 PF02711.9 KOG97916.1 - 2.1 9.2 5.2 4.4 8.1 3.6 1.6 1 0 0 1 1 1 0 E4 protein Stap_Strp_toxin PF01123.15 KOG97916.1 - 4.2 7.9 11.3 0.29 11.6 2.3 2.8 1 1 2 3 3 3 0 Staphylococcal/Streptococcal toxin, OB-fold domain WD40 PF00400.27 KOG97917.1 - 3e-62 204.4 14.5 8.9e-09 34.9 0.1 11.0 11 0 0 11 11 11 9 WD domain, G-beta repeat Utp13 PF08625.6 KOG97917.1 - 4.3e-49 165.7 0.3 8e-49 164.9 0.2 1.5 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Nup160 PF11715.3 KOG97917.1 - 5.1e-08 31.5 3.9 0.92 7.5 0.0 5.8 4 1 2 6 6 6 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 KOG97917.1 - 0.00024 19.9 5.9 0.075 11.7 0.1 4.2 2 1 1 4 4 4 2 Nup133 N terminal like CRF1 PF10380.4 KOG97918.1 - 8.4e-36 123.0 4.2 8.4e-36 123.0 2.9 6.3 5 2 0 5 5 5 1 Transcription factor CRF1 Svf1 PF08622.5 KOG97920.1 - 2.8e-100 335.4 0.1 3.4e-100 335.1 0.1 1.1 1 0 0 1 1 1 1 Svf1-like Tox-ART-HYE1 PF15634.1 KOG97920.1 - 0.039 12.9 0.2 0.32 9.9 0.1 2.1 2 0 0 2 2 2 0 HYE1 signature containing ADP-ribosyltransferase Cyclin_N PF00134.18 KOG97921.1 - 0.035 13.6 0.7 0.057 12.9 0.5 1.3 1 0 0 1 1 1 0 Cyclin, N-terminal domain Zn_clus PF00172.13 KOG97923.1 - 3.6e-08 33.1 11.9 5.5e-08 32.5 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LMBR1 PF04791.11 KOG97923.1 - 0.067 11.7 3.5 0.043 12.4 0.1 2.1 2 0 0 2 2 2 0 LMBR1-like membrane protein Ras PF00071.17 KOG97924.1 - 9.4e-51 171.4 0.0 1.1e-50 171.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG97924.1 - 4.8e-14 52.8 0.0 6.4e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOG97924.1 - 5.5e-07 28.9 0.0 7.3e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Aminotran_5 PF00266.14 KOG97925.1 - 2.9e-11 42.7 0.0 4.6e-11 42.0 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-V EST1_DNA_bind PF10373.4 KOG97926.1 - 3.8e-39 134.5 2.8 8.3e-39 133.4 1.4 1.9 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.4 KOG97926.1 - 9.6e-19 67.6 0.2 9.6e-19 67.6 0.1 2.1 2 0 0 2 2 2 1 Telomerase activating protein Est1 TPR_11 PF13414.1 KOG97926.1 - 0.067 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 TPR repeat Topoisom_bac PF01131.15 KOG97927.1 - 5e-90 302.2 0.0 7.3e-90 301.6 0.0 1.2 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 KOG97927.1 - 3.8e-23 81.3 0.0 7.7e-23 80.3 0.0 1.5 1 0 0 1 1 1 1 Toprim domain Transp_cyt_pur PF02133.10 KOG97928.1 - 4.2e-69 233.2 40.2 5.7e-69 232.7 27.9 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin FHA PF00498.21 KOG97929.1 - 4.2e-18 65.2 0.5 1.1e-16 60.6 0.2 2.8 2 0 0 2 2 2 1 FHA domain GCD14 PF08704.5 KOG97929.1 - 0.16 11.4 1.7 0.31 10.5 1.2 1.5 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit CENP-H PF05837.7 KOG97929.1 - 5.7 7.1 15.1 2.8 8.1 1.7 2.6 2 0 0 2 2 2 0 Centromere protein H (CENP-H) BPL_LplA_LipB PF03099.14 KOG97930.1 - 7.7e-22 77.6 0.1 1.3e-21 76.8 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family PI3Ka PF00613.15 KOG97931.1 - 1.3e-77 259.1 2.5 2e-77 258.5 1.7 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.22 KOG97931.1 - 1.7e-47 161.8 0.0 2.4e-46 158.0 0.0 2.5 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.19 KOG97931.1 - 2.8e-26 92.0 0.1 7.8e-26 90.5 0.1 1.8 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 Rep_fac_C PF08542.6 KOG97931.1 - 0.064 13.2 0.2 0.21 11.6 0.1 1.8 1 0 0 1 1 1 0 Replication factor C C-terminal domain AlcCBM31 PF11606.3 KOG97931.1 - 0.11 12.4 0.0 0.43 10.5 0.0 2.0 1 0 0 1 1 1 0 Family 31 carbohydrate binding protein DUF221 PF02714.10 KOG97932.1 - 1.7e-98 329.5 22.1 3.3e-98 328.5 15.3 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 KOG97932.1 - 9.5e-42 142.2 1.4 9.5e-42 142.2 0.9 2.4 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 KOG97932.1 - 1.7e-17 63.7 0.0 3.1e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) DUF3753 PF12575.3 KOG97932.1 - 0.025 14.3 0.0 0.025 14.3 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3753) Arv1 PF04161.8 KOG97933.1 - 6.1e-81 271.2 14.9 6.1e-81 271.2 10.3 1.6 2 0 0 2 2 2 1 Arv1-like family ATP_bind_1 PF03029.12 KOG97934.1 - 3.6e-87 291.8 0.0 4e-87 291.6 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_10 PF12846.2 KOG97934.1 - 6.6e-05 22.4 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain ArgK PF03308.11 KOG97934.1 - 0.00036 19.3 0.1 0.0012 17.6 0.0 1.7 2 0 0 2 2 2 1 ArgK protein AAA_17 PF13207.1 KOG97934.1 - 0.00049 20.9 0.0 0.00091 20.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 KOG97934.1 - 0.0013 18.6 0.0 0.0025 17.7 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.17 KOG97934.1 - 0.0064 16.6 0.0 0.025 14.7 0.0 2.1 2 0 0 2 2 1 1 RNA helicase ABC_tran PF00005.22 KOG97934.1 - 0.008 16.4 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter KAP_NTPase PF07693.9 KOG97934.1 - 0.011 14.7 0.0 0.025 13.5 0.0 1.6 2 0 0 2 2 2 0 KAP family P-loop domain AAA_29 PF13555.1 KOG97934.1 - 0.014 14.9 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.1 KOG97934.1 - 0.019 14.5 0.0 0.044 13.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 KOG97934.1 - 0.019 14.6 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 KOG97934.1 - 0.024 14.7 0.0 0.041 14.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.12 KOG97934.1 - 0.028 14.2 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 DUF258 PF03193.11 KOG97934.1 - 0.031 13.4 0.0 0.066 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 KOG97934.1 - 0.039 13.3 0.0 0.39 10.1 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.1 KOG97934.1 - 0.043 13.6 0.0 0.073 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.13 KOG97934.1 - 0.054 12.6 0.0 0.086 12.0 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_30 PF13604.1 KOG97934.1 - 0.067 12.7 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Septin PF00735.13 KOG97934.1 - 0.076 12.0 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Septin T2SE PF00437.15 KOG97934.1 - 0.078 11.8 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein cobW PF02492.14 KOG97934.1 - 0.12 11.7 0.0 0.77 9.1 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.1 KOG97934.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain TrwB_AAD_bind PF10412.4 KOG97934.1 - 0.15 10.6 0.0 0.22 10.1 0.0 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Peptidase_M24 PF00557.19 KOG97935.1 - 7.9e-50 169.3 0.0 1e-49 168.9 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 dCMP_cyt_deam_1 PF00383.17 KOG97936.1 - 1.1e-20 73.1 0.4 1.5e-20 72.7 0.3 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.6 KOG97936.1 - 1.3e-11 44.5 0.0 8.5e-11 41.9 0.0 1.9 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.1 KOG97936.1 - 0.32 10.3 5.3 5.4 6.3 0.2 2.1 1 1 0 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases zf-DHHC PF01529.15 KOG97937.1 - 8e-34 116.5 9.2 8e-34 116.5 6.4 2.1 1 1 1 2 2 2 1 DHHC palmitoyltransferase DUF4131 PF13567.1 KOG97937.1 - 0.027 13.8 4.1 0.26 10.6 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) SDF PF00375.13 KOG97937.1 - 0.052 12.3 0.1 0.052 12.3 0.1 1.9 2 1 0 2 2 2 0 Sodium:dicarboxylate symporter family DUF2142 PF09913.4 KOG97937.1 - 0.21 10.1 5.7 1.7 7.2 0.7 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2142) DUF35_N PF12172.3 KOG97937.1 - 0.25 11.3 2.5 0.55 10.2 1.8 1.5 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) SNF2_N PF00176.18 KOG97938.1 - 5.1e-42 143.7 0.1 1.5e-41 142.1 0.0 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain zf-RING_2 PF13639.1 KOG97938.1 - 3e-10 39.7 7.9 7.2e-10 38.5 5.5 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 KOG97938.1 - 5.5e-09 35.5 8.7 1.5e-08 34.1 6.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOG97938.1 - 1.2e-08 34.7 10.5 3e-08 33.5 7.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOG97938.1 - 1.6e-06 27.6 9.4 3.1e-06 26.7 6.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOG97938.1 - 2.2e-06 27.3 7.9 4.9e-06 26.1 5.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.2 KOG97938.1 - 1.6e-05 24.8 3.6 4.7e-05 23.4 2.5 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger Helicase_C PF00271.26 KOG97938.1 - 0.0013 18.5 0.0 0.0039 17.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_4 PF15227.1 KOG97938.1 - 0.0026 17.5 8.2 0.0073 16.1 5.7 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Apc11 PF12861.2 KOG97938.1 - 0.0032 17.2 1.3 0.33 10.8 2.5 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.9 KOG97938.1 - 0.79 9.2 12.3 0.18 11.3 5.9 1.9 2 0 0 2 2 2 0 P-11 zinc finger zf-RING_UBOX PF13445.1 KOG97938.1 - 2.8 7.7 10.4 0.36 10.5 2.3 3.2 2 1 1 3 3 3 0 RING-type zinc-finger Pkinase PF00069.20 KOG97939.1 - 3.1e-57 193.6 0.0 5.8e-57 192.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG97939.1 - 2.4e-21 75.9 0.0 9e-20 70.8 0.0 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG97939.1 - 8.6e-05 21.6 0.1 0.11 11.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 KOG97939.1 - 0.00064 18.8 0.0 0.0013 17.7 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC_tran PF00005.22 KOG97940.1 - 7.8e-44 149.3 0.1 9.8e-22 77.7 0.0 4.5 4 2 0 4 4 2 2 ABC transporter AAA_21 PF13304.1 KOG97940.1 - 1.8e-17 64.2 0.4 0.0015 18.5 0.0 4.4 3 1 1 4 4 4 4 AAA domain SMC_N PF02463.14 KOG97940.1 - 2.2e-16 59.7 0.1 4.6e-06 26.0 0.0 4.1 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KOG97940.1 - 1.4e-09 38.6 2.5 0.0015 18.9 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.1 KOG97940.1 - 1.3e-08 35.6 0.0 0.0061 17.3 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 KOG97940.1 - 1.5e-08 34.0 0.0 0.0028 17.1 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 KOG97940.1 - 1.7e-08 33.8 0.0 0.00012 21.3 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOG97940.1 - 2.9e-08 33.9 0.0 0.00071 19.7 0.0 3.5 4 0 0 4 4 2 2 AAA domain AAA_28 PF13521.1 KOG97940.1 - 5e-08 33.0 0.0 0.0073 16.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.1 KOG97940.1 - 5e-07 29.1 0.0 0.42 9.6 0.0 3.9 3 1 0 4 4 4 2 AAA ATPase domain MMR_HSR1 PF01926.18 KOG97940.1 - 9.1e-07 28.8 0.0 0.0058 16.5 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase RNA_helicase PF00910.17 KOG97940.1 - 9.4e-07 28.9 0.0 0.11 12.7 0.0 3.1 2 0 0 2 2 2 2 RNA helicase Miro PF08477.8 KOG97940.1 - 1e-06 29.2 0.0 0.031 14.7 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein AAA PF00004.24 KOG97940.1 - 2.2e-06 27.9 0.1 0.09 12.9 0.0 4.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.18 KOG97940.1 - 2.9e-06 27.2 0.0 6.6e-05 22.7 0.0 2.6 2 0 0 2 2 2 1 Dynamin family Arch_ATPase PF01637.13 KOG97940.1 - 3.4e-06 26.9 0.0 0.055 13.1 0.0 3.0 3 0 0 3 3 2 2 Archaeal ATPase ArgK PF03308.11 KOG97940.1 - 4e-06 25.8 0.1 0.06 12.1 0.0 2.4 2 0 0 2 2 2 2 ArgK protein SbcCD_C PF13558.1 KOG97940.1 - 4.1e-06 26.6 0.0 0.018 14.9 0.0 3.2 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.1 KOG97940.1 - 8.5e-06 26.0 0.1 0.061 13.6 0.0 3.3 3 0 0 3 3 2 2 AAA domain AAA_10 PF12846.2 KOG97940.1 - 8.9e-06 25.3 0.0 0.24 10.8 0.0 3.2 4 1 0 4 4 3 2 AAA-like domain AAA_16 PF13191.1 KOG97940.1 - 9e-06 25.7 1.3 0.14 12.1 0.1 4.2 3 1 0 3 3 3 1 AAA ATPase domain AAA_13 PF13166.1 KOG97940.1 - 1.1e-05 24.1 1.0 1.2 7.5 0.0 4.1 3 1 0 3 3 3 2 AAA domain AAA_14 PF13173.1 KOG97940.1 - 1.5e-05 24.8 0.0 0.14 12.0 0.0 3.7 4 0 0 4 4 3 1 AAA domain AAA_33 PF13671.1 KOG97940.1 - 1.8e-05 24.6 0.0 0.14 12.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain MobB PF03205.9 KOG97940.1 - 4.2e-05 23.2 0.0 0.38 10.4 0.0 2.9 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B DUF87 PF01935.12 KOG97940.1 - 8.9e-05 22.4 0.4 0.33 10.7 0.0 4.2 5 0 0 5 5 3 1 Domain of unknown function DUF87 NACHT PF05729.7 KOG97940.1 - 0.00017 21.2 0.0 0.091 12.4 0.0 2.5 2 0 0 2 2 2 1 NACHT domain ParcG PF10274.4 KOG97940.1 - 0.00018 21.4 0.6 2 8.2 0.0 3.2 2 1 0 3 3 3 1 Parkin co-regulated protein MutS_V PF00488.16 KOG97940.1 - 0.00019 20.9 0.0 0.14 11.5 0.0 2.4 2 0 0 2 2 2 1 MutS domain V Rad17 PF03215.10 KOG97940.1 - 0.00025 19.8 0.0 0.22 10.1 0.0 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein PduV-EutP PF10662.4 KOG97940.1 - 0.00062 19.2 0.0 0.36 10.3 0.0 2.9 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Adeno_IVa2 PF02456.10 KOG97940.1 - 0.0024 16.6 0.1 0.51 8.9 0.0 2.3 2 0 0 2 2 2 1 Adenovirus IVa2 protein HEAT_2 PF13646.1 KOG97940.1 - 0.0028 17.8 0.1 0.73 10.1 0.0 3.5 2 1 1 3 3 3 1 HEAT repeats CLASP_N PF12348.3 KOG97940.1 - 0.006 15.9 1.5 0.063 12.6 1.0 2.4 1 1 0 1 1 1 1 CLASP N terminal HEAT PF02985.17 KOG97940.1 - 0.0077 16.2 0.0 3.5 7.9 0.0 3.9 3 0 0 3 3 3 0 HEAT repeat UME PF08064.8 KOG97940.1 - 0.014 15.3 1.2 0.41 10.6 0.2 2.7 1 1 1 2 2 2 0 UME (NUC010) domain cobW PF02492.14 KOG97940.1 - 0.015 14.7 0.0 8.9 5.7 0.0 2.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.1 KOG97940.1 - 0.016 14.6 0.0 6.2 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain Vac14_Fab1_bd PF12755.2 KOG97940.1 - 0.018 15.4 0.5 11 6.4 0.0 3.8 3 1 1 4 4 3 0 Vacuolar 14 Fab1-binding region Mg_chelatase PF01078.16 KOG97940.1 - 0.018 14.1 0.1 1 8.4 0.0 3.1 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Septin PF00735.13 KOG97940.1 - 0.018 14.0 0.1 1.3 7.9 0.0 2.8 3 0 0 3 3 3 0 Septin AAA_30 PF13604.1 KOG97940.1 - 0.019 14.5 0.1 10 5.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain T2SE PF00437.15 KOG97940.1 - 0.027 13.3 0.0 0.48 9.2 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 KOG97940.1 - 0.03 13.8 0.1 3.1 7.2 0.0 3.0 3 0 0 3 3 3 0 FtsK/SpoIIIE family NTPase_1 PF03266.10 KOG97940.1 - 0.032 13.9 0.2 6.7 6.3 0.0 2.7 2 0 0 2 2 2 0 NTPase ATP-synt_ab PF00006.20 KOG97940.1 - 0.033 13.6 0.1 3 7.2 0.0 2.8 3 0 0 3 3 2 0 ATP synthase alpha/beta family, nucleotide-binding domain PRK PF00485.13 KOG97940.1 - 0.05 13.1 0.0 2.3 7.7 0.0 2.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family FeoB_N PF02421.13 KOG97940.1 - 0.068 12.4 0.4 1 8.6 0.1 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_5 PF07728.9 KOG97940.1 - 0.098 12.3 0.0 24 4.6 0.0 3.4 4 0 0 4 4 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 KOG97940.1 - 0.12 12.1 0.2 6.3 6.6 0.0 2.7 2 0 0 2 2 2 0 Part of AAA domain HEAT_EZ PF13513.1 KOG97940.1 - 0.26 11.8 3.1 1.7e+02 2.8 0.0 5.1 6 1 1 7 7 4 0 HEAT-like repeat EF-hand_7 PF13499.1 KOG97941.1 - 2.1e-05 24.5 0.7 2.1e-05 24.5 0.5 2.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOG97941.1 - 0.0011 18.0 0.8 0.54 9.6 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOG97941.1 - 0.0018 18.0 1.1 0.28 11.1 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOG97941.1 - 0.0057 16.2 2.5 2.1 8.0 0.0 3.0 3 1 0 3 3 3 2 EF-hand domain pair Mpv17_PMP22 PF04117.7 KOG97942.1 - 4.6e-29 99.8 4.9 4.6e-29 99.8 3.4 1.6 2 0 0 2 2 2 1 Mpv17 / PMP22 family ABC1 PF03109.11 KOG97943.1 - 1.9e-33 114.9 0.0 5.2e-33 113.5 0.0 1.8 1 0 0 1 1 1 1 ABC1 family Tfb4 PF03850.9 KOG97943.1 - 8.6e-05 21.9 0.3 0.00034 19.9 0.1 1.8 2 0 0 2 2 2 1 Transcription factor Tfb4 RIO1 PF01163.17 KOG97943.1 - 0.00078 18.8 0.1 0.004 16.5 0.0 2.0 2 0 0 2 2 2 1 RIO1 family Gaa1 PF04114.9 KOG97943.1 - 0.042 12.5 0.0 0.074 11.7 0.0 1.3 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component bZIP_2 PF07716.10 KOG97944.1 - 0.00058 19.6 3.4 0.00058 19.6 2.3 3.4 2 1 1 3 3 3 1 Basic region leucine zipper ATG16 PF08614.6 KOG97944.1 - 0.002 18.0 15.4 0.0027 17.5 10.5 1.4 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) APG6 PF04111.7 KOG97944.1 - 0.0099 14.9 13.4 0.011 14.7 9.3 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 bZIP_1 PF00170.16 KOG97944.1 - 0.011 15.6 1.9 0.011 15.6 1.3 3.1 1 1 2 3 3 3 0 bZIP transcription factor TPR_MLP1_2 PF07926.7 KOG97944.1 - 0.015 15.0 13.5 0.015 15.0 9.4 1.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.7 KOG97944.1 - 0.035 13.8 4.4 0.075 12.8 3.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) IncA PF04156.9 KOG97944.1 - 0.036 13.6 15.7 0.047 13.2 10.9 1.2 1 0 0 1 1 1 0 IncA protein CENP-Q PF13094.1 KOG97944.1 - 0.065 13.2 13.9 0.099 12.6 9.7 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit COG5 PF10392.4 KOG97944.1 - 0.35 10.8 9.2 1.1 9.2 6.3 1.9 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Tropomyosin PF00261.15 KOG97944.1 - 0.49 9.4 18.6 0.077 12.0 8.1 2.0 1 1 1 2 2 2 0 Tropomyosin DUF2203 PF09969.4 KOG97944.1 - 0.56 10.4 6.6 0.29 11.3 3.0 1.7 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF972 PF06156.8 KOG97944.1 - 1.1 9.5 16.0 0.34 11.2 3.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) SPX PF03105.14 KOG97944.1 - 1.6 8.4 9.2 2.3 7.9 6.4 1.1 1 0 0 1 1 1 0 SPX domain FlaC_arch PF05377.6 KOG97944.1 - 1.6 8.6 9.8 6.6 6.7 0.6 3.2 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Uso1_p115_C PF04871.8 KOG97944.1 - 2.1 8.3 16.6 3.3 7.6 11.3 1.5 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4404 PF14357.1 KOG97944.1 - 2.8 8.4 11.5 0.51 10.7 5.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) CENP-F_leu_zip PF10473.4 KOG97944.1 - 2.9 7.7 21.6 0.77 9.6 9.6 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATP-synt_E PF05680.7 KOG97944.1 - 3.5 7.6 8.1 13 5.8 5.6 2.0 1 1 0 1 1 1 0 ATP synthase E chain DUF724 PF05266.9 KOG97944.1 - 4.3 6.9 14.5 10 5.6 10.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DivIC PF04977.10 KOG97944.1 - 8.4 5.9 13.1 0.76 9.3 3.2 2.6 1 1 1 2 2 2 0 Septum formation initiator Zn_clus PF00172.13 KOG97946.1 - 6.1e-08 32.4 8.3 1.2e-07 31.5 5.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glycogen_syn PF05693.8 KOG97948.1 - 0 1084.1 0.0 0 1083.9 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.15 KOG97948.1 - 9.2e-11 41.4 0.0 3.1e-07 29.9 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 KOG97948.1 - 9.8e-06 25.7 0.0 1.9e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain DUF3788 PF12663.2 KOG97948.1 - 0.1 12.2 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3788) Cpn60_TCP1 PF00118.19 KOG97949.1 - 1.7e-115 386.4 6.4 2e-115 386.2 4.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DAGK_cat PF00781.19 KOG97950.1 - 1.4e-27 95.6 0.0 2.9e-27 94.6 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain MCRS_N PF13325.1 KOG97950.1 - 0.11 11.9 2.4 0.21 11.0 1.7 1.3 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein RXT2_N PF08595.6 KOG97950.1 - 0.22 11.3 7.1 0.58 9.9 4.9 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal Ras PF00071.17 KOG97951.1 - 8.1e-58 194.3 0.4 9.6e-58 194.1 0.3 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG97951.1 - 6.3e-23 81.5 0.1 1.4e-22 80.3 0.0 1.6 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 KOG97951.1 - 3.2e-16 59.0 0.4 3.7e-16 58.8 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOG97951.1 - 4.6e-06 25.9 0.1 5.8e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KOG97951.1 - 1e-05 25.4 0.0 1.8e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KOG97951.1 - 1.5e-05 24.3 0.0 2.6e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 KOG97951.1 - 4.7e-05 22.8 0.0 0.00026 20.4 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arch_ATPase PF01637.13 KOG97951.1 - 0.00012 21.8 1.0 0.00034 20.3 0.0 1.8 1 1 1 2 2 2 1 Archaeal ATPase PduV-EutP PF10662.4 KOG97951.1 - 0.0017 17.8 0.4 0.013 14.9 0.3 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.1 KOG97951.1 - 0.0021 18.1 0.0 0.014 15.5 0.0 2.1 1 1 1 2 2 2 1 AAA domain DUF258 PF03193.11 KOG97951.1 - 0.018 14.2 0.0 0.044 12.9 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_24 PF13479.1 KOG97951.1 - 0.019 14.5 0.1 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.12 KOG97951.1 - 0.032 13.7 0.1 1.1 8.7 0.0 2.3 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.1 KOG97951.1 - 0.032 14.2 0.0 0.059 13.3 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.7 KOG97951.1 - 0.087 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Red1 PF07964.6 KOG97952.1 - 1.5e-200 668.0 47.7 1.7e-200 667.7 33.1 1.1 1 0 0 1 1 1 1 Rec10 / Red1 Ribosomal_S28e PF01200.13 KOG97953.1 - 1.9e-33 113.9 3.8 2e-33 113.8 2.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e XLF PF09302.6 KOG97954.1 - 2e-28 99.2 0.8 3.1e-28 98.6 0.5 1.3 1 0 0 1 1 1 1 XLF (XRCC4-like factor) Fungal_trans PF04082.13 KOG97955.1 - 3.7e-14 52.2 5.4 7.2e-14 51.2 3.8 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG97955.1 - 1.5e-06 27.9 10.6 2.8e-06 27.1 6.0 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Longin PF13774.1 KOG97957.1 - 1.3e-20 72.7 1.1 2.4e-20 71.8 0.6 1.6 1 1 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.16 KOG97957.1 - 2.3e-17 62.3 0.2 4.8e-17 61.3 0.1 1.6 1 0 0 1 1 1 1 Synaptobrevin DUF1664 PF07889.7 KOG97957.1 - 0.00076 19.2 0.4 0.0013 18.5 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Phi-29_GP16_7 PF06720.6 KOG97957.1 - 0.021 14.5 0.6 0.032 13.9 0.4 1.2 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 Mst1_SARAH PF11629.3 KOG97957.1 - 0.34 10.7 1.9 0.92 9.3 0.6 2.1 1 1 1 2 2 2 0 C terminal SARAH domain of Mst1 DcpS PF05652.7 KOG97958.1 - 4.2e-41 139.8 0.1 6.4e-41 139.2 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.3 KOG97958.1 - 6.5e-32 110.1 0.4 1.6e-31 108.9 0.1 1.7 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 KOG97958.1 - 0.079 13.4 0.6 5.2 7.6 0.2 3.0 3 0 0 3 3 3 0 HIT domain DUF4187 PF13821.1 KOG97959.1 - 4.1e-17 61.5 1.0 4.1e-17 61.5 0.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) G-patch PF01585.18 KOG97959.1 - 1.2e-13 50.5 0.8 2.4e-13 49.6 0.5 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 KOG97959.1 - 0.0018 18.0 0.8 0.0018 18.0 0.6 2.6 3 1 0 3 3 3 1 DExH-box splicing factor binding site Flu_PB1 PF00602.12 KOG97959.1 - 0.0033 15.2 0.4 0.0046 14.7 0.2 1.2 1 0 0 1 1 1 1 Influenza RNA-dependent RNA polymerase subunit PB1 Cnd1 PF12717.2 KOG97960.1 - 1.5e-55 187.8 9.1 5.7e-50 169.6 0.2 4.9 5 1 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.2 KOG97960.1 - 3.7e-50 169.8 3.4 3.7e-50 169.8 2.4 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT_2 PF13646.1 KOG97960.1 - 4.3e-13 49.3 0.1 1.5e-05 25.2 0.0 4.5 4 1 2 6 6 6 3 HEAT repeats HEAT PF02985.17 KOG97960.1 - 2.8e-11 42.5 7.9 0.048 13.7 0.0 7.0 7 0 0 7 7 7 4 HEAT repeat HEAT_EZ PF13513.1 KOG97960.1 - 1e-07 32.2 0.1 0.28 11.7 0.0 5.1 3 1 1 4 4 4 2 HEAT-like repeat DUF2435 PF10363.4 KOG97960.1 - 0.00074 19.3 2.5 0.9 9.4 0.0 5.1 3 1 1 4 4 4 1 Protein of unknown function (DUF2435) CBM_21 PF03370.8 KOG97961.1 - 1.9e-21 76.1 5.8 4.7e-21 74.8 4.0 1.7 1 0 0 1 1 1 1 Putative phosphatase regulatory subunit Peptidase_C93 PF06035.6 KOG97961.1 - 0.001 18.4 0.0 0.0023 17.3 0.0 1.5 1 0 0 1 1 1 1 Bacterial transglutaminase-like cysteine proteinase BTLCP MCM PF00493.18 KOG97962.1 - 1.7e-143 477.4 0.5 2.2e-143 477.0 0.3 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 KOG97962.1 - 1.1e-19 71.1 0.5 1.1e-19 71.1 0.3 2.1 2 1 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 KOG97962.1 - 3e-06 26.5 0.0 0.00063 18.9 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KOG97962.1 - 3.6e-06 26.7 0.0 1.2e-05 25.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 KOG97962.1 - 0.00058 19.4 0.1 0.004 16.7 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 KOG97962.1 - 0.02 14.3 0.0 1.4 8.4 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain Mg_chelatase_2 PF13335.1 KOG97962.1 - 0.086 13.2 0.1 0.27 11.6 0.1 1.9 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PPV_E1_N PF00524.13 KOG97962.1 - 0.09 13.0 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 E1 Protein, N terminal domain LSM PF01423.17 KOG97963.1 - 2.3e-17 62.2 0.9 2.9e-17 61.9 0.6 1.1 1 0 0 1 1 1 1 LSM domain DEAD PF00270.24 KOG97964.1 - 1.5e-43 148.2 0.6 3e-43 147.2 0.4 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG97964.1 - 1.4e-21 76.0 0.0 2.4e-10 40.1 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.10 KOG97964.1 - 1.8e-06 27.9 1.0 1.9e-05 24.5 0.1 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DnaI_N PF07319.6 KOG97964.1 - 0.012 15.8 3.9 0.29 11.4 0.2 3.1 2 1 0 2 2 2 0 Primosomal protein DnaI N-terminus SecA_DEAD PF07517.9 KOG97964.1 - 0.047 12.9 0.2 4.3 6.5 0.0 2.7 2 0 0 2 2 2 0 SecA DEAD-like domain CMS1 PF14617.1 KOG97964.1 - 0.062 12.3 0.0 0.062 12.3 0.0 2.7 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit CPSF73-100_C PF11718.3 KOG97965.1 - 7.7e-61 205.1 3.1 1.3e-60 204.4 2.2 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.3 KOG97965.1 - 2.5e-31 108.2 0.0 1.4e-30 105.8 0.0 2.2 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B PF00753.22 KOG97965.1 - 3.4e-17 62.7 0.2 5.7e-17 62.0 0.1 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 KOG97965.1 - 2e-12 47.0 0.2 1.9e-11 43.8 0.1 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain RMMBL PF07521.7 KOG97965.1 - 4.2e-11 42.4 0.0 8.4e-11 41.5 0.0 1.6 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_3 PF13483.1 KOG97965.1 - 3.1e-06 26.9 0.0 1e-05 25.3 0.0 1.9 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Zn_clus PF00172.13 KOG97966.1 - 1.1e-06 28.4 10.4 2.7e-06 27.1 7.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RF-1 PF00472.15 KOG97967.1 - 3.1e-19 68.8 4.1 6.8e-19 67.7 2.9 1.6 1 1 0 1 1 1 1 RF-1 domain Involucrin_N PF10583.4 KOG97967.1 - 0.042 14.1 1.4 0.21 11.9 0.2 2.3 2 0 0 2 2 2 0 Involucrin of squamous epithelia N-terminus DUF1640 PF07798.6 KOG97968.1 - 1.2e-08 35.1 7.7 1.6e-08 34.8 5.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Membr_traf_MHD PF10540.4 KOG97968.1 - 0.037 13.8 6.1 0.13 12.0 2.2 2.6 1 1 1 2 2 2 0 Munc13 (mammalian uncoordinated) homology domain Tweety PF04906.8 KOG97968.1 - 0.042 12.2 1.1 0.071 11.5 0.8 1.3 1 0 0 1 1 1 0 Tweety ECH PF00378.15 KOG97969.1 - 7.8e-16 57.9 0.0 1.4e-15 57.1 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Methyltransf_16 PF10294.4 KOG97970.1 - 2.1e-15 56.5 0.0 2.9e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 KOG97970.1 - 5.7e-05 22.8 0.0 8.4e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOG97970.1 - 0.00065 20.2 0.0 0.0011 19.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOG97970.1 - 0.017 14.7 0.1 0.031 13.8 0.1 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 KOG97970.1 - 0.097 13.1 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 KOG97970.1 - 0.13 12.7 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Antimicrobial_1 PF08018.6 KOG97970.1 - 0.55 10.1 2.1 1.1 9.2 1.5 1.5 1 0 0 1 1 1 0 Frog antimicrobial peptide CBM_19 PF03427.8 KOG97971.1 - 2e-07 30.6 10.8 2e-07 30.6 7.5 5.2 1 1 4 5 5 5 1 Carbohydrate binding domain (family 19) GCIP PF13324.1 KOG97972.1 - 1.1e-09 37.9 0.1 1.3e-09 37.7 0.1 1.2 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting CorA PF01544.13 KOG97972.1 - 0.062 12.3 0.1 0.39 9.7 0.0 2.3 2 1 0 3 3 3 0 CorA-like Mg2+ transporter protein Hus1 PF04005.7 KOG97973.1 - 6.4e-22 77.8 0.2 1.1e-15 57.3 0.0 2.3 2 0 0 2 2 2 2 Hus1-like protein GTP_EFTU PF00009.22 KOG97974.1 - 3e-50 170.2 0.1 2.5e-49 167.2 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain LepA_C PF06421.7 KOG97974.1 - 1e-39 134.7 6.9 2.9e-39 133.3 4.8 1.8 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.19 KOG97974.1 - 3.3e-18 65.3 0.0 6.9e-18 64.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 KOG97974.1 - 9e-07 28.9 1.3 2.1e-06 27.7 0.9 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KOG97974.1 - 6.6e-05 22.8 0.0 0.00019 21.3 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase NAD_binding_10 PF13460.1 KOG97975.1 - 5.1e-09 36.3 0.0 4.8e-08 33.2 0.0 2.1 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOG97975.1 - 9.4e-07 28.5 0.0 4.3e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family adh_short PF00106.20 KOG97975.1 - 1.5e-06 28.2 0.0 4.3e-06 26.7 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase 3Beta_HSD PF01073.14 KOG97975.1 - 4.4e-05 22.3 0.0 6.5e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 KOG97975.1 - 0.0016 17.4 0.0 0.16 10.8 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.8 KOG97975.1 - 0.11 11.7 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family IF-2B PF01008.12 KOG97976.1 - 3.4e-93 311.7 0.1 4.5e-93 311.2 0.1 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF1804 PF08822.6 KOG97976.1 - 0.0002 21.1 0.0 0.00057 19.6 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1804) TPR_2 PF07719.12 KOG97977.1 - 3.2e-07 29.7 0.0 0.00051 19.7 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOG97977.1 - 5.1e-07 29.2 0.0 0.003 17.1 0.0 2.6 1 1 2 3 3 3 3 TPR repeat TPR_19 PF14559.1 KOG97977.1 - 3.2e-06 27.3 1.3 5.8e-06 26.5 0.1 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOG97977.1 - 4e-06 26.2 0.1 0.01 15.4 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 KOG97977.1 - 0.00017 21.6 0.4 0.00079 19.5 0.3 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 KOG97977.1 - 0.00033 21.0 1.7 0.00056 20.3 0.0 2.2 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOG97977.1 - 0.00044 20.8 0.1 0.0031 18.1 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOG97977.1 - 0.004 16.9 1.6 0.13 12.1 0.4 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOG97977.1 - 0.005 16.7 0.5 0.045 13.6 0.0 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.1 KOG97977.1 - 0.011 14.7 0.1 0.024 13.7 0.0 1.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOG97977.1 - 0.013 15.2 0.0 0.087 12.6 0.0 2.3 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOG97977.1 - 0.02 15.3 0.1 0.079 13.4 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.9 KOG97977.1 - 0.044 14.2 1.6 0.06 13.8 0.2 2.0 2 0 0 2 2 1 0 Tetratricopeptide repeat Ras PF00071.17 KOG97978.1 - 1.4e-51 174.0 0.0 1.7e-51 173.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG97978.1 - 5.2e-18 65.6 0.0 1.1e-17 64.5 0.0 1.6 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 KOG97978.1 - 4.1e-12 45.6 0.0 5.8e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.17 KOG97978.1 - 0.00023 21.3 0.2 0.0019 18.3 0.2 2.1 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.7 KOG97978.1 - 0.00056 19.1 0.0 0.00081 18.5 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOG97978.1 - 0.0046 16.4 0.6 0.043 13.2 0.4 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 KOG97978.1 - 0.0088 15.2 0.0 0.015 14.5 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit KaiC PF06745.8 KOG97978.1 - 0.014 14.4 0.2 0.023 13.8 0.1 1.3 1 0 0 1 1 1 0 KaiC Pox_A32 PF04665.7 KOG97978.1 - 0.027 13.7 0.1 0.048 12.9 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein G-alpha PF00503.15 KOG97978.1 - 0.043 12.4 3.0 1.3 7.5 0.1 2.9 2 1 1 3 3 3 0 G-protein alpha subunit AAA_22 PF13401.1 KOG97978.1 - 0.052 13.6 0.2 0.17 12.0 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KOG97978.1 - 0.064 13.1 0.3 0.15 11.8 0.1 1.7 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 KOG97978.1 - 0.12 12.0 0.2 0.22 11.1 0.0 1.5 2 0 0 2 2 2 0 NACHT domain ATP_sub_h PF10775.4 KOG97979.1 - 3.2e-25 87.6 0.3 4.2e-25 87.2 0.2 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h Rax2 PF12768.2 KOG97980.1 - 0.015 14.4 0.1 0.015 14.4 0.1 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF4097 PF13349.1 KOG97980.1 - 0.044 13.3 0.2 0.066 12.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4097) EphA2_TM PF14575.1 KOG97980.1 - 0.14 12.5 0.1 0.26 11.6 0.1 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Baculo_11_kDa PF06143.6 KOG97980.1 - 0.66 9.3 3.0 0.85 9.0 1.7 1.5 1 1 0 1 1 1 0 Baculovirus 11 kDa family zf-U1 PF06220.7 KOG97981.1 - 8.7e-19 66.8 5.8 1.9e-18 65.6 4.0 1.6 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_jaz PF12171.3 KOG97981.1 - 1.1 9.4 8.5 1 9.5 4.2 2.3 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding G_glu_transpept PF01019.16 KOG97982.1 - 3.6e-143 477.7 0.0 4.4e-143 477.4 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Cys_Met_Meta_PP PF01053.15 KOG97984.1 - 4.3e-150 499.2 0.0 4.9e-150 499.1 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 KOG97984.1 - 2.4e-11 43.3 0.0 3.8e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 KOG97984.1 - 1.7e-10 40.4 0.0 2.4e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOG97984.1 - 6.1e-10 38.7 0.0 1.2e-09 37.7 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 KOG97984.1 - 3e-08 32.8 0.1 4.7e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Met_gamma_lyase PF06838.6 KOG97984.1 - 2e-05 23.0 0.1 3.1e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methionine gamma-lyase GDC-P PF02347.11 KOG97984.1 - 0.0063 15.2 0.0 0.0089 14.7 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein SelA PF03841.8 KOG97984.1 - 0.0071 15.1 0.1 0.031 13.0 0.0 1.8 1 1 0 1 1 1 1 L-seryl-tRNA selenium transferase Phg_2220_C PF09524.5 KOG97984.1 - 0.047 13.6 0.1 0.22 11.5 0.0 2.1 2 0 0 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) CPSase_L_D2 PF02786.12 KOG97984.1 - 0.11 11.8 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Aconitase PF00330.15 KOG97985.1 - 1.4e-182 607.3 0.0 3.1e-182 606.2 0.0 1.5 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 KOG97985.1 - 2e-47 160.5 0.0 4e-47 159.6 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain PI3_PI4_kinase PF00454.22 KOG97986.1 - 4.8e-44 150.5 0.0 2.5e-43 148.2 0.0 2.3 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 KOG97986.1 - 7.4e-37 126.3 0.0 1.6e-36 125.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) UQ_con PF00179.21 KOG97987.1 - 2.4e-35 121.0 0.1 2.6e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Polysacc_deac_1 PF01522.16 KOG97988.1 - 2.9e-23 81.8 0.0 5e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 KOG97988.1 - 2.6e-05 23.3 0.0 3.7e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Polysacc_deac_1 PF01522.16 KOG97990.1 - 3.5e-26 91.2 0.0 5.3e-26 90.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 KOG97990.1 - 0.0012 17.8 0.0 0.0016 17.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 GRIP PF01465.15 KOG97991.1 - 1e-15 56.9 0.8 2.9e-15 55.4 0.5 1.9 1 0 0 1 1 1 1 GRIP domain MscS_porin PF12795.2 KOG97991.1 - 1.9e-07 30.6 24.9 1.9e-07 30.6 17.2 6.1 2 2 4 6 6 6 2 Mechanosensitive ion channel porin domain Spc7 PF08317.6 KOG97991.1 - 0.00045 18.9 141.9 0.019 13.6 15.7 6.8 1 1 6 7 7 7 4 Spc7 kinetochore protein Reo_sigmaC PF04582.7 KOG97991.1 - 0.0043 16.2 58.0 0.18 10.9 3.8 6.3 2 2 5 7 7 7 6 Reovirus sigma C capsid protein HJURP_C PF12347.3 KOG97991.1 - 0.018 14.5 0.0 0.018 14.5 0.0 3.0 3 0 0 3 3 3 0 Holliday junction regulator protein family C-terminal repeat DNA_ligase_A_C PF04679.10 KOG97991.1 - 2.6 8.4 5.7 2.9 8.3 0.1 4.0 3 0 0 3 3 3 0 ATP dependent DNA ligase C terminal region RasGEF PF00617.14 KOG97992.1 - 2.5e-58 196.9 3.8 6.6e-58 195.5 0.9 2.9 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 KOG97992.1 - 4.5e-19 68.4 3.3 6.4e-19 67.9 0.0 3.2 3 0 0 3 3 3 1 RasGEF N-terminal motif SH3_1 PF00018.23 KOG97992.1 - 3.9e-07 29.3 0.2 1e-06 27.9 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOG97992.1 - 3.6e-06 26.4 0.1 7.6e-06 25.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOG97992.1 - 3e-05 23.4 0.1 6e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ribonucleas_3_3 PF14622.1 KOG97994.1 - 2e-23 82.7 0.0 3.4e-23 82.0 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.21 KOG97994.1 - 2.9e-05 24.5 0.0 5.7e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease III domain L27_2 PF09045.5 KOG97994.1 - 0.12 11.9 0.6 0.65 9.5 0.4 2.2 1 1 0 1 1 1 0 L27_2 DUF3680 PF12441.3 KOG97994.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3680) GIT_SHD PF08518.6 KOG97995.1 - 1.3e-05 24.4 3.6 0.072 12.4 0.1 3.0 3 0 0 3 3 3 2 Spa2 homology domain (SHD) of GIT Cnl2_NKP2 PF09447.5 KOG97996.1 - 1.5e-14 53.3 1.2 5.2e-14 51.6 0.2 2.1 3 0 0 3 3 3 1 Cnl2/NKP2 family protein Hemerythrin PF01814.18 KOG97996.1 - 0.066 13.3 0.6 0.11 12.6 0.4 1.5 1 1 0 1 1 1 0 Hemerythrin HHE cation binding domain Telomerase_RBD PF12009.3 KOG97997.1 - 3.6e-34 117.6 4.0 3.6e-34 117.6 2.7 2.7 4 0 0 4 4 4 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.22 KOG97997.1 - 9e-09 34.9 3.2 1e-08 34.8 0.7 2.2 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) AIP3 PF03915.8 KOG97998.1 - 1.1e-154 515.5 19.4 1.1e-154 515.5 13.4 2.1 2 1 0 2 2 2 1 Actin interacting protein 3 Mus7 PF09462.5 KOG97999.1 - 6.8e-61 206.8 14.3 1.2e-44 153.2 6.3 2.3 1 1 1 2 2 2 2 Mus7/MMS22 family SNF5 PF04855.7 KOG98000.1 - 1.4e-62 211.3 3.9 3.8e-60 203.3 2.7 2.4 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 zf-C3HC4_2 PF13923.1 KOG98001.1 - 1.5e-09 37.6 10.2 2.7e-09 36.8 7.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.19 KOG98001.1 - 2.5e-09 36.5 2.8 5.6e-09 35.4 1.9 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.1 KOG98001.1 - 1.6e-08 34.1 6.3 2.5e-08 33.4 4.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOG98001.1 - 6.3e-08 32.2 10.3 1.1e-07 31.4 7.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 KOG98001.1 - 1.4e-06 28.0 5.2 2.7e-06 27.1 3.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 KOG98001.1 - 5.5e-05 22.7 9.5 0.0001 21.9 6.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KOG98001.1 - 0.00027 20.7 8.4 0.00053 19.8 5.8 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 KOG98001.1 - 0.0016 18.1 6.5 0.0016 18.1 4.5 2.0 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.1 KOG98001.1 - 0.0039 16.7 4.9 0.0084 15.6 3.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.1 KOG98001.1 - 0.11 12.3 3.4 0.2 11.4 2.3 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-P11 PF03854.9 KOG98001.1 - 0.13 11.7 3.0 0.27 10.7 2.1 1.4 1 0 0 1 1 1 0 P-11 zinc finger Pex24p PF06398.6 KOG98002.1 - 5.7e-89 298.4 9.2 1.1e-88 297.4 6.4 1.4 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Ribosomal_L38e PF01781.13 KOG98003.1 - 1.2e-27 95.4 2.2 1.3e-27 95.3 1.5 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family PapD_C PF02753.12 KOG98003.1 - 0.081 12.7 0.1 0.11 12.3 0.1 1.2 1 0 0 1 1 1 0 Pili assembly chaperone PapD, C-terminal domain DUF4112 PF13430.1 KOG98004.1 - 2.1e-33 114.4 0.3 2.7e-33 114.0 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) HABP4_PAI-RBP1 PF04774.10 KOG98005.1 - 0.00023 21.6 0.5 0.00027 21.3 0.3 1.3 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family CTP_transf_2 PF01467.21 KOG98006.1 - 3.9e-36 124.4 0.3 6.1e-36 123.8 0.0 1.5 2 0 0 2 2 2 1 Cytidylyltransferase BRCT PF00533.21 KOG98008.1 - 5e-09 36.1 0.0 1.7e-08 34.4 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 KOG98008.1 - 0.00038 20.2 0.0 0.00071 19.3 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain DUF3006 PF11213.3 KOG98008.1 - 0.00052 19.6 0.1 0.0034 17.0 0.0 2.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) fn3 PF00041.16 KOG98008.1 - 0.0028 17.7 0.0 0.012 15.7 0.0 2.1 1 0 0 1 1 1 1 Fibronectin type III domain Mid2 PF04478.7 KOG98009.1 - 3.5e-75 250.6 1.5 3.5e-75 250.6 1.0 3.8 1 1 4 5 5 5 1 Mid2 like cell wall stress sensor DUF605 PF04652.11 KOG98009.1 - 0.0015 17.9 18.9 0.0015 17.9 13.1 1.5 2 0 0 2 2 2 1 Vta1 like SKG6 PF08693.5 KOG98009.1 - 0.0044 16.3 3.0 0.0044 16.3 2.1 3.2 2 0 0 2 2 2 1 Transmembrane alpha-helix domain DUF912 PF06024.7 KOG98009.1 - 0.15 12.0 0.0 0.15 12.0 0.0 3.1 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) SOG2 PF10428.4 KOG98009.1 - 0.35 9.4 0.0 0.35 9.4 0.0 2.2 1 1 1 2 2 2 0 RAM signalling pathway protein Ribosomal_S25 PF03297.10 KOG98010.1 - 7.5e-45 151.2 4.6 8.4e-45 151.1 3.2 1.0 1 0 0 1 1 1 1 S25 ribosomal protein Ftsk_gamma PF09397.5 KOG98010.1 - 0.00011 21.8 0.1 0.00017 21.2 0.0 1.3 1 0 0 1 1 1 1 Ftsk gamma domain EAP30 PF04157.11 KOG98010.1 - 0.025 13.7 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family HTH_CodY PF08222.6 KOG98010.1 - 0.043 13.1 0.1 0.067 12.5 0.1 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain TAF4 PF05236.9 KOG98010.1 - 0.065 12.5 0.1 0.065 12.5 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Gp49 PF05973.9 KOG98010.1 - 0.11 12.4 1.1 3.6 7.6 0.4 2.2 2 0 0 2 2 2 0 Phage derived protein Gp49-like (DUF891) MerR PF00376.18 KOG98010.1 - 0.12 11.9 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 MerR family regulatory protein Ran_BP1 PF00638.13 KOG98011.1 - 1e-39 135.3 1.2 2.9e-39 133.8 0.1 2.3 2 0 0 2 2 2 1 RanBP1 domain NUP50 PF08911.6 KOG98011.1 - 1.1e-13 51.3 3.9 1.1e-13 51.3 2.7 4.8 4 2 0 4 4 4 1 NUP50 (Nucleoporin 50 kDa) Nucleoporin_FG PF13634.1 KOG98011.1 - 6.6 7.0 95.9 0.92 9.7 15.0 5.1 2 1 3 5 5 5 0 Nucleoporin FG repeat region MA3 PF02847.12 KOG98012.1 - 3.8e-32 110.3 1.0 1.4e-31 108.4 0.2 2.3 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.14 KOG98012.1 - 2.1e-24 86.1 3.0 2.1e-24 86.1 2.1 2.1 2 0 0 2 2 2 1 MIF4G domain WH2 PF02205.15 KOG98013.1 - 8.6e-15 53.7 0.1 4e-10 38.9 0.1 2.8 2 0 0 2 2 2 2 WH2 motif Ribosomal_L10 PF00466.15 KOG98014.1 - 2.4e-27 94.7 0.2 4e-27 94.0 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 KOG98014.1 - 1.6e-19 70.0 3.4 3.9e-19 68.8 1.0 2.2 2 0 0 2 2 2 1 60s Acidic ribosomal protein Glucan_synthase PF02364.10 KOG98016.1 - 0 1452.7 0.0 0 1452.3 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 KOG98016.1 - 1.1e-39 134.9 0.1 2.7e-39 133.7 0.1 1.7 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Glyco_hydro_72 PF03198.9 KOG98017.1 - 3.6e-138 459.8 0.9 4.9e-138 459.4 0.7 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 KOG98017.1 - 3.7e-16 59.3 1.7 3.7e-16 59.3 1.2 2.5 3 0 0 3 3 3 1 X8 domain DUF4163 PF13739.1 KOG98017.1 - 0.49 11.2 3.0 0.61 10.8 0.2 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4163) 6PF2K PF01591.13 KOG98018.1 - 9.3e-77 257.0 1.2 1.3e-76 256.5 0.8 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 KOG98018.1 - 8.3e-21 74.7 0.0 1.5e-20 73.9 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 KOG98018.1 - 0.14 12.0 0.0 0.47 10.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain Glyco_hydro_108 PF05838.7 KOG98018.1 - 0.15 12.2 0.0 0.8 9.8 0.0 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase 108 HEAT PF02985.17 KOG98020.1 - 5.6e-16 57.1 18.3 0.0018 18.1 0.0 11.3 13 0 0 13 13 13 4 HEAT repeat HEAT_EZ PF13513.1 KOG98020.1 - 6.8e-14 51.8 7.9 2.8e-05 24.4 0.0 9.4 8 2 2 10 10 10 2 HEAT-like repeat IBN_N PF03810.14 KOG98020.1 - 5.5e-12 45.4 7.9 8.4e-12 44.8 1.5 4.0 4 1 1 5 5 5 1 Importin-beta N-terminal domain HEAT_2 PF13646.1 KOG98020.1 - 8.9e-12 45.1 8.3 0.00041 20.5 0.0 7.2 2 1 4 6 6 6 3 HEAT repeats RICTOR_V PF14668.1 KOG98020.1 - 8.1e-05 22.4 0.6 0.015 15.2 0.1 4.3 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 CLASP_N PF12348.3 KOG98020.1 - 0.00034 20.0 1.8 0.4 10.0 0.0 4.7 4 1 0 5 5 5 1 CLASP N terminal Cnd3 PF12719.2 KOG98020.1 - 0.0017 17.4 0.3 0.084 11.8 0.1 3.0 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain Arm PF00514.18 KOG98020.1 - 0.019 14.7 8.3 0.98 9.3 0.0 5.8 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.2 KOG98020.1 - 0.031 14.6 0.5 31 5.0 0.0 4.7 5 1 1 6 6 6 0 Vacuolar 14 Fab1-binding region Mito_carr PF00153.22 KOG98021.1 - 7.1e-57 189.1 0.2 3e-19 68.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein ORMDL PF04061.9 KOG98022.1 - 3.1e-53 178.9 7.0 3.7e-53 178.7 4.8 1.1 1 0 0 1 1 1 1 ORMDL family DUF4271 PF14093.1 KOG98022.1 - 0.001 18.8 0.7 0.0013 18.4 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4271) DUF3784 PF12650.2 KOG98022.1 - 0.94 9.4 3.8 21 5.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) CN_hydrolase PF00795.17 KOG98023.1 - 2.5e-35 121.5 0.0 5.4e-35 120.4 0.0 1.5 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase SBBP PF06739.6 KOG98023.1 - 0.034 13.9 0.0 0.092 12.5 0.0 1.7 1 0 0 1 1 1 0 Beta-propeller repeat LRR_4 PF12799.2 KOG98024.1 - 3.8e-06 26.3 16.2 0.0081 15.7 0.2 5.5 5 1 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOG98024.1 - 1.3e-05 24.8 5.8 0.011 15.4 0.5 5.4 5 1 1 6 6 6 1 Leucine rich repeat LRR_1 PF00560.28 KOG98024.1 - 0.0018 18.0 8.4 12 6.4 0.0 7.0 6 1 1 7 7 7 2 Leucine Rich Repeat F-box-like PF12937.2 KOG98024.1 - 0.0054 16.4 0.7 1.8 8.3 0.0 3.1 3 0 0 3 3 3 2 F-box-like LRR_7 PF13504.1 KOG98024.1 - 0.0083 16.1 4.3 69 4.3 0.0 6.3 6 0 0 6 6 6 0 Leucine rich repeat LRR_6 PF13516.1 KOG98024.1 - 2 8.7 12.8 7.9 6.8 0.1 6.1 6 0 0 6 6 6 0 Leucine Rich repeat Transaldolase PF00923.14 KOG98026.1 - 3.1e-100 335.0 0.3 3.6e-100 334.7 0.2 1.0 1 0 0 1 1 1 1 Transaldolase DUF740 PF05340.7 KOG98026.1 - 0.11 10.8 0.0 0.15 10.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) IlvC PF01450.14 KOG98027.1 - 1.2e-47 161.4 0.0 1.8e-47 160.9 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain IlvN PF07991.7 KOG98027.1 - 1.2e-45 154.8 0.0 1.7e-45 154.3 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.10 KOG98027.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Bromodomain PF00439.20 KOG98029.1 - 3.6e-29 100.5 2.5 5.1e-14 51.9 0.1 2.9 3 0 0 3 3 3 2 Bromodomain BAH PF01426.13 KOG98029.1 - 5.3e-22 77.8 0.1 1.8e-21 76.0 0.0 2.0 2 0 0 2 2 2 1 BAH domain Borrelia_orfD PF02999.9 KOG98029.1 - 0.11 12.6 0.1 0.11 12.6 0.1 2.2 3 0 0 3 3 3 0 Borrelia orf-D family Lyase_1 PF00206.15 KOG98030.1 - 4e-24 85.3 0.0 7.6e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.4 KOG98030.1 - 1.9e-16 59.7 0.0 7.6e-16 57.8 0.0 2.1 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus DUF1331 PF07048.6 KOG98030.1 - 0.058 12.8 0.1 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) MKT1_N PF12247.3 KOG98031.1 - 0.11 12.8 2.3 1.6 9.0 0.1 3.0 3 1 0 3 3 3 0 Temperature dependent protein affecting M2 dsRNA replication Metallophos PF00149.23 KOG98032.1 - 2.1e-15 56.6 0.2 3.8e-15 55.8 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOG98032.1 - 4.7e-07 29.7 0.0 8.1e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Pkinase PF00069.20 KOG98034.1 - 2.2e-68 230.2 0.4 1.8e-60 204.3 0.0 2.6 1 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98034.1 - 1e-49 168.9 0.3 4e-47 160.4 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Ras_bdg_2 PF14847.1 KOG98034.1 - 2.9e-35 120.3 0.1 6.9e-35 119.1 0.1 1.7 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.12 KOG98034.1 - 1e-11 44.4 0.7 3e-11 42.9 0.0 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 KOG98034.1 - 1.6e-07 31.4 0.0 4.8e-07 29.8 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.1 KOG98034.1 - 2.4e-06 26.7 0.0 5.6e-05 22.2 0.0 2.6 2 1 0 2 2 2 1 Kinase-like DUF780 PF05611.6 KOG98034.1 - 3.7 8.3 5.4 2.4 8.9 2.1 1.9 2 0 0 2 2 2 0 Caenorhabditis elegans protein of unknown function (DUF780) PIN_4 PF13638.1 KOG98035.1 - 0.022 14.8 0.0 0.064 13.3 0.0 1.8 1 1 0 1 1 1 0 PIN domain DUF2462 PF09495.5 KOG98036.1 - 1.4e-18 67.3 10.1 2e-18 66.9 7.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2462) Glutaredoxin PF00462.19 KOG98037.1 - 3e-05 23.9 0.0 4.7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF953 PF06110.6 KOG98037.1 - 0.0023 17.3 1.0 0.0032 16.9 0.7 1.4 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.1 KOG98037.1 - 0.011 15.3 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Transp_cyt_pur PF02133.10 KOG98038.1 - 2.4e-09 36.2 5.9 2.6e-09 36.1 4.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Transp_cyt_pur PF02133.10 KOG98039.1 - 1.1e-67 228.5 38.3 1.5e-67 228.0 26.5 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin F-box-like PF12937.2 KOG98040.1 - 4.1e-06 26.4 3.1 1.1e-05 25.1 2.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 KOG98040.1 - 0.00064 19.3 2.3 0.0017 17.9 1.6 1.8 1 0 0 1 1 1 1 F-box domain HSP70 PF00012.15 KOG98041.1 - 2.7e-213 709.2 12.9 3.1e-213 709.0 8.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOG98041.1 - 1e-18 67.0 1.6 7.6e-17 60.8 0.4 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 KOG98041.1 - 0.0072 15.9 0.0 0.015 14.9 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain P21-Arc PF04062.9 KOG98042.1 - 3.5e-63 212.5 0.0 4.1e-63 212.2 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit CNH PF00780.17 KOG98043.1 - 2.6e-80 269.7 1.3 2.7e-80 269.7 0.2 1.6 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.1 KOG98043.1 - 6e-39 133.0 0.0 6e-39 133.0 0.0 3.1 2 1 0 2 2 2 1 Pleckstrin homology domain RhoGEF PF00621.15 KOG98043.1 - 9.3e-33 113.6 1.0 4.8e-32 111.2 0.0 2.4 2 0 0 2 2 2 1 RhoGEF domain DEP PF00610.16 KOG98043.1 - 9.6e-13 47.6 0.0 2.6e-12 46.3 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ELO PF01151.13 KOG98044.1 - 2.6e-61 207.0 27.6 3.4e-61 206.7 19.2 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family CENP-B_dimeris PF09026.5 KOG98045.1 - 0.0041 17.3 3.7 0.012 15.8 2.6 1.8 1 0 0 1 1 1 1 Centromere protein B dimerisation domain Actino_peptide PF14408.1 KOG98045.1 - 0.36 10.7 9.6 0.86 9.5 6.6 1.7 1 0 0 1 1 1 0 Ribosomally synthesized peptide in actinomycetes Sigma70_ner PF04546.8 KOG98045.1 - 0.53 9.8 2.9 1 8.9 2.0 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Tom22 PF04281.8 KOG98045.1 - 0.59 9.6 9.0 1.2 8.6 0.0 2.5 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 DUF4611 PF15387.1 KOG98045.1 - 1 9.5 6.5 13 6.0 3.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) zf-C2H2_6 PF13912.1 KOG98046.1 - 0.00076 19.2 10.2 0.0065 16.3 0.4 4.0 3 1 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.21 KOG98046.1 - 0.0018 18.4 4.0 0.0018 18.4 2.8 4.8 4 1 0 4 4 4 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KOG98046.1 - 0.0041 17.3 3.7 0.0041 17.3 2.5 5.1 4 1 1 5 5 5 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOG98046.1 - 0.0058 16.8 3.2 0.0058 16.8 2.2 4.8 5 0 0 5 5 4 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOG98046.1 - 0.035 14.2 4.0 0.26 11.4 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C3HC4_3 PF13920.1 KOG98046.1 - 0.092 12.4 4.9 3.4 7.3 0.2 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOG98046.1 - 0.12 12.1 4.7 20 5.0 0.3 3.5 3 0 0 3 3 3 0 Ring finger domain zf-RING_3 PF14369.1 KOG98046.1 - 0.36 10.8 4.4 0.64 10.0 0.2 3.0 3 0 0 3 3 3 0 zinc-finger zf-Di19 PF05605.7 KOG98046.1 - 1 9.5 10.1 0.94 9.6 2.8 3.5 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.9 KOG98046.1 - 1.4 8.3 5.0 0.64 9.5 0.1 2.4 1 1 1 2 2 2 0 Rad50 zinc hook motif zf-RING_5 PF14634.1 KOG98046.1 - 1.8 8.3 8.3 10 5.9 0.3 3.4 3 0 0 3 3 3 0 zinc-RING finger domain Zn-ribbon_8 PF09723.5 KOG98046.1 - 2.4 8.1 6.0 78 3.3 0.1 3.7 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2HC_2 PF13913.1 KOG98046.1 - 3.4 7.4 12.2 2.2 8.0 0.8 3.7 3 0 0 3 3 3 0 zinc-finger of a C2HC-type FBPase PF00316.15 KOG98048.1 - 1.8e-141 470.6 0.0 2.1e-141 470.4 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase SecY PF00344.15 KOG98050.1 - 2e-88 296.6 18.5 2.5e-88 296.3 12.8 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 KOG98050.1 - 1.1e-18 66.4 0.9 6.8e-18 63.8 0.1 2.9 2 0 0 2 2 2 1 Plug domain of Sec61p Claudin_3 PF06653.6 KOG98050.1 - 0.11 12.2 7.1 0.9 9.2 0.0 3.1 3 0 0 3 3 3 0 Tight junction protein, Claudin-like CRAL_TRIO PF00650.15 KOG98051.1 - 3.9e-42 143.4 0.1 7.2e-42 142.5 0.1 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 KOG98051.1 - 3e-12 46.4 0.5 1.2e-11 44.5 0.1 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 KOG98051.1 - 3.9e-06 26.8 0.1 7.9e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF615 PF04751.9 KOG98051.1 - 0.0024 17.5 0.0 0.0043 16.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF615) SIR2 PF02146.12 KOG98051.1 - 0.083 12.6 0.0 7.4 6.2 0.0 2.4 2 0 0 2 2 2 0 Sir2 family tRNA-synt_1 PF00133.17 KOG98053.1 - 2.7e-56 190.8 3.9 3.6e-32 111.1 3.4 6.6 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.1 KOG98053.1 - 1.2e-38 132.2 0.0 2.1e-38 131.4 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.6 KOG98053.1 - 1.3e-34 119.5 0.0 2.6e-26 92.1 0.0 4.3 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1d PF00750.14 KOG98053.1 - 0.0001 21.2 0.0 0.00022 20.1 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (R) tRNA-synt_1e PF01406.14 KOG98053.1 - 0.00017 20.7 0.0 0.11 11.6 0.0 2.7 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain AAA_23 PF13476.1 KOG98054.1 - 2.5e-19 70.3 3.1 2.5e-19 70.3 2.2 5.6 3 2 2 5 5 5 1 AAA domain SMC_N PF02463.14 KOG98054.1 - 4.2e-17 62.1 38.0 3e-16 59.3 26.4 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 KOG98054.1 - 9.7e-06 24.8 29.3 9.7e-06 24.8 20.3 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 KOG98054.1 - 0.00044 19.7 0.0 0.0011 18.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 KOG98054.1 - 0.0035 17.3 0.3 0.0035 17.3 0.2 4.5 3 2 1 4 4 4 2 AAA domain SbcCD_C PF13558.1 KOG98054.1 - 0.031 14.2 0.0 0.1 12.5 0.0 1.9 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Reo_sigmaC PF04582.7 KOG98054.1 - 0.15 11.1 19.7 0.32 10.1 0.1 4.4 2 2 1 4 4 4 0 Reovirus sigma C capsid protein Filament PF00038.16 KOG98054.1 - 2.3 7.5 76.8 0.22 10.9 5.7 6.2 4 2 1 5 5 5 0 Intermediate filament protein IKI3 PF04762.7 KOG98055.1 - 0 1157.4 2.2 0 1157.4 1.5 1.9 3 0 0 3 3 3 1 IKI3 family TPR_2 PF07719.12 KOG98055.1 - 0.064 13.2 12.0 7.2 6.7 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOG98055.1 - 0.33 10.6 6.7 5.7 6.7 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOG98055.1 - 0.75 9.4 10.3 0.64 9.7 1.7 3.4 3 0 0 3 3 3 0 TPR repeat TPR_8 PF13181.1 KOG98055.1 - 1.4 8.8 6.9 7.9 6.5 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Vac14_Fig4_bd PF11916.3 KOG98057.1 - 5.2e-70 234.2 6.8 1.6e-69 232.6 4.7 1.9 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.2 KOG98057.1 - 2.1e-47 159.4 1.3 1.1e-38 131.5 0.0 4.6 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT PF02985.17 KOG98057.1 - 2.8e-11 42.5 5.4 0.00024 20.9 0.0 7.3 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.1 KOG98057.1 - 2.3e-07 31.0 0.0 0.026 14.7 0.0 4.8 4 1 0 4 4 4 1 HEAT repeats CLASP_N PF12348.3 KOG98057.1 - 3.7e-07 29.7 4.0 0.022 14.1 1.1 4.4 4 1 0 4 4 4 2 CLASP N terminal MMS19_C PF12460.3 KOG98057.1 - 6.9e-07 28.3 5.1 0.018 13.8 1.2 3.5 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal HEAT_EZ PF13513.1 KOG98057.1 - 1.1e-06 28.9 0.3 0.6 10.6 0.0 5.7 6 0 0 6 6 6 1 HEAT-like repeat Cnd1 PF12717.2 KOG98057.1 - 6.5e-05 22.8 13.4 0.012 15.4 1.2 4.8 6 0 0 6 6 6 3 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.4 KOG98057.1 - 0.00087 19.2 4.8 0.11 12.4 0.3 3.4 4 0 0 4 4 4 2 Parkin co-regulated protein Arm PF00514.18 KOG98057.1 - 0.0087 15.8 4.7 1.5 8.7 0.0 4.2 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Ipi1_N PF12333.3 KOG98057.1 - 0.033 14.1 1.2 0.7 9.8 0.0 3.3 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation zf-C2H2_2 PF12756.2 KOG98058.1 - 2.5e-31 107.7 6.7 3.1e-29 101.0 1.7 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.7 KOG98058.1 - 1 9.1 8.2 5.3 6.7 0.2 3.2 3 0 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_jaz PF12171.3 KOG98058.1 - 7.8 6.7 16.9 3.5 7.8 1.3 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Ribosomal_S14 PF00253.16 KOG98059.1 - 1.2e-17 63.0 4.8 1.3e-17 62.9 3.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF4428 PF14471.1 KOG98059.1 - 0.0083 15.8 0.3 0.0094 15.6 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4428) Prim_Zn_Ribbon PF08273.7 KOG98059.1 - 0.26 11.3 1.7 4.6 7.3 0.1 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase RNA_POL_M_15KD PF02150.11 KOG98059.1 - 0.4 10.4 2.1 7 6.4 0.1 2.1 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit ZZ PF00569.12 KOG98059.1 - 0.69 9.4 3.4 3.7 7.1 2.4 2.0 1 1 0 1 1 1 0 Zinc finger, ZZ type Peptidase_M16 PF00675.15 KOG98060.1 - 2.4e-39 134.4 0.1 6.4e-39 133.0 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 KOG98060.1 - 8.1e-38 129.9 0.5 9.5e-21 74.2 0.0 3.2 3 0 0 3 3 3 2 Peptidase M16 inactive domain DUF2106 PF09879.4 KOG98061.1 - 0.092 12.0 0.0 0.1 11.9 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2106) Neuregulin PF02158.10 KOG98061.1 - 0.11 11.2 0.0 0.12 11.0 0.0 1.0 1 0 0 1 1 1 0 Neuregulin family CFEM PF05730.6 KOG98062.1 - 1.4e-08 34.3 14.1 3.7e-08 33.0 9.7 1.7 1 0 0 1 1 1 1 CFEM domain DUF2201_N PF13203.1 KOG98062.1 - 0.1 11.7 6.9 0.12 11.5 4.8 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF605 PF04652.11 KOG98062.1 - 0.68 9.2 22.1 0.79 9.0 15.3 1.0 1 0 0 1 1 1 0 Vta1 like CCDC84 PF14968.1 KOG98062.1 - 2.5 7.5 14.4 3.1 7.2 10.0 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 DUF936 PF06075.7 KOG98062.1 - 3.9 6.2 27.6 4.5 6.0 19.1 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) DUF572 PF04502.8 KOG98062.1 - 6.7 5.8 21.5 7.9 5.5 14.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF566 PF04484.7 KOG98062.1 - 9.7 5.5 32.4 12 5.2 22.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) Arrestin_N PF00339.24 KOG98063.1 - 5.1e-06 26.3 0.1 2e-05 24.4 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain ATP-synt_10 PF05176.9 KOG98064.1 - 1e-84 283.7 0.4 1.3e-84 283.4 0.3 1.0 1 0 0 1 1 1 1 ATP10 protein zf-RING_5 PF14634.1 KOG98065.1 - 2.2e-07 30.5 8.6 4.5e-07 29.4 6.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-MIZ PF02891.15 KOG98065.1 - 2.3e-06 27.0 9.0 5.5e-06 25.7 6.2 1.7 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-C3HC4_2 PF13923.1 KOG98065.1 - 0.011 15.7 4.8 0.11 12.5 3.4 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 KOG98065.1 - 0.057 13.2 2.5 0.16 11.7 1.7 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.1 KOG98065.1 - 0.4 10.4 6.7 0.9 9.2 4.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOG98065.1 - 0.78 9.6 10.4 3.2 7.6 7.2 2.0 1 1 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.1 KOG98065.1 - 4.4 6.9 8.7 26 4.4 3.1 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 COX7C PF02935.11 KOG98066.1 - 6e-26 90.0 0.9 7.3e-26 89.7 0.7 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Sec1 PF00995.18 KOG98067.1 - 3.9e-86 289.9 13.5 6.2e-86 289.2 9.3 1.3 1 1 0 1 1 1 1 Sec1 family AAA PF00004.24 KOG98068.1 - 7.2e-91 301.2 0.0 4.4e-44 149.8 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOG98068.1 - 2.2e-13 49.7 0.0 9.9e-06 24.7 0.0 3.2 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 KOG98068.1 - 4.1e-12 46.4 0.1 6.1e-06 26.3 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.9 KOG98068.1 - 1.7e-11 43.9 0.1 3.1e-05 23.7 0.0 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 KOG98068.1 - 4e-11 43.1 0.5 0.00016 21.8 0.0 4.5 2 2 1 3 3 3 1 AAA domain AAA_2 PF07724.9 KOG98068.1 - 1e-09 38.5 0.0 0.00011 22.2 0.0 2.9 2 2 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 KOG98068.1 - 3.2e-09 36.7 0.0 0.00012 21.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 KOG98068.1 - 6.3e-07 30.2 0.0 0.0053 17.5 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.1 KOG98068.1 - 8.7e-07 28.9 0.0 0.00044 20.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 KOG98068.1 - 1.7e-06 27.0 0.0 0.0042 15.8 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus RNA_helicase PF00910.17 KOG98068.1 - 9.3e-06 25.7 0.0 0.13 12.3 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_19 PF13245.1 KOG98068.1 - 1.3e-05 24.8 2.1 0.0037 16.9 0.1 3.3 3 0 0 3 3 3 1 Part of AAA domain AAA_28 PF13521.1 KOG98068.1 - 2.4e-05 24.3 0.0 0.059 13.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 KOG98068.1 - 2.7e-05 23.6 6.7 0.11 11.8 0.0 4.2 2 2 1 3 3 3 2 AAA domain Sigma54_activ_2 PF14532.1 KOG98068.1 - 5.1e-05 23.3 0.0 0.098 12.6 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain Mg_chelatase PF01078.16 KOG98068.1 - 6.4e-05 22.2 0.1 0.14 11.2 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 KOG98068.1 - 0.00019 20.5 0.1 0.11 11.5 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin Bac_DnaA PF00308.13 KOG98068.1 - 0.00032 20.4 0.0 0.029 14.0 0.0 2.6 2 1 0 2 2 2 1 Bacterial dnaA protein NACHT PF05729.7 KOG98068.1 - 0.00037 20.2 0.1 0.055 13.1 0.0 3.5 3 1 0 4 4 4 1 NACHT domain Rad17 PF03215.10 KOG98068.1 - 0.00047 18.9 0.0 0.032 12.9 0.0 2.3 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein IstB_IS21 PF01695.12 KOG98068.1 - 0.0014 18.1 0.0 1.8 7.9 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein Arch_ATPase PF01637.13 KOG98068.1 - 0.0014 18.3 0.0 0.65 9.6 0.0 2.9 2 1 0 2 2 2 1 Archaeal ATPase AAA_3 PF07726.6 KOG98068.1 - 0.0019 17.8 0.0 2.2 7.9 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 KOG98068.1 - 0.0036 17.2 0.0 0.0094 15.8 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain KaiC PF06745.8 KOG98068.1 - 0.0098 15.0 0.5 9.2 5.2 0.0 3.5 2 1 0 3 3 3 0 KaiC ABC_tran PF00005.22 KOG98068.1 - 0.0098 16.1 0.1 0.18 12.1 0.0 2.3 2 0 0 2 2 2 1 ABC transporter AAA_11 PF13086.1 KOG98068.1 - 0.012 15.1 0.0 0.62 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 KOG98068.1 - 0.014 14.8 0.0 7.1 6.0 0.0 3.6 2 2 0 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.13 KOG98068.1 - 0.015 14.8 0.0 0.13 11.7 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.1 KOG98068.1 - 0.018 15.3 0.0 0.57 10.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 KOG98068.1 - 0.034 13.7 0.4 6 6.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.8 KOG98068.1 - 0.038 12.9 0.0 1.5 7.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_30 PF13604.1 KOG98068.1 - 0.04 13.4 0.4 0.15 11.6 0.0 2.1 3 0 0 3 3 3 0 AAA domain UPF0079 PF02367.12 KOG98068.1 - 0.089 12.4 0.1 3.9 7.1 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AFG1_ATPase PF03969.11 KOG98068.1 - 0.13 11.0 0.0 0.3 9.8 0.0 1.5 1 0 0 1 1 1 0 AFG1-like ATPase NTPase_1 PF03266.10 KOG98068.1 - 0.14 11.8 0.8 4.4 6.9 0.0 3.3 2 2 2 4 4 4 0 NTPase DSHCT PF08148.7 KOG98069.1 - 2.1e-57 193.2 0.1 3.9e-57 192.3 0.1 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 KOG98069.1 - 1.4e-22 79.9 0.0 3.1e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG98069.1 - 1.9e-06 27.6 0.0 5.3e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain rRNA_proc-arch PF13234.1 KOG98069.1 - 1e-05 24.8 0.3 2.6e-05 23.5 0.2 1.7 1 0 0 1 1 1 1 rRNA-processing arch domain Bromodomain PF00439.20 KOG98070.1 - 8e-42 141.0 0.5 5.6e-21 74.2 0.1 2.7 2 0 0 2 2 2 2 Bromodomain STAT_int PF02865.12 KOG98070.1 - 0.22 11.4 2.3 0.39 10.6 0.2 2.4 3 0 0 3 3 3 0 STAT protein, protein interaction domain Dus PF01207.12 KOG98071.1 - 1.7e-42 145.3 0.0 2.1e-32 112.2 0.0 2.4 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.19 KOG98071.1 - 0.00025 20.6 6.6 0.012 15.2 0.3 2.8 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C2H2_4 PF13894.1 KOG98072.1 - 6.2e-05 23.0 12.8 0.054 13.8 0.3 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOG98072.1 - 0.0028 17.7 4.5 0.14 12.2 0.0 3.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 KOG98072.1 - 0.0047 17.1 17.0 0.099 13.0 1.2 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KOG98072.1 - 0.0082 16.3 16.8 0.031 14.5 0.4 3.5 3 0 0 3 3 3 2 Zinc-finger double domain Nucleoplasmin PF03066.10 KOG98072.1 - 2.8 7.4 16.7 5.6 6.4 11.6 1.5 1 0 0 1 1 1 0 Nucleoplasmin PBP1_TM PF14812.1 KOG98072.1 - 7.6 6.9 17.8 2.8 8.3 8.8 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2715 PF10895.3 KOG98073.1 - 0.088 12.2 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2715) Dus PF01207.12 KOG98074.1 - 3.8e-86 288.7 0.0 4.8e-86 288.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Ribosomal_L31e PF01198.14 KOG98075.1 - 0.00014 21.4 0.1 0.00014 21.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L31e DUF4050 PF13259.1 KOG98076.1 - 2.4e-22 79.1 2.7 4.9e-22 78.1 1.9 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF4050) SPACA7 PF15307.1 KOG98076.1 - 1.4 9.1 9.1 5 7.2 0.3 2.5 2 0 0 2 2 2 0 Sperm acrosome-associated protein 7 Utp21 PF04192.7 KOG98078.1 - 1.1e-82 276.6 0.2 1.6e-82 276.1 0.1 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.27 KOG98078.1 - 5.2e-22 76.8 15.5 1.5e-08 34.1 0.2 8.7 9 0 0 9 9 9 5 WD domain, G-beta repeat PQQ_2 PF13360.1 KOG98078.1 - 9.4e-06 25.2 0.0 0.015 14.7 0.0 3.4 3 1 0 3 3 3 2 PQQ-like domain Nucleoporin_N PF08801.6 KOG98078.1 - 0.00019 20.2 2.4 0.13 10.9 0.0 3.7 3 1 0 3 3 3 2 Nup133 N terminal like Apc4_WD40 PF12894.2 KOG98078.1 - 0.00062 19.2 0.0 4.6 6.8 0.0 3.8 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.11 KOG98078.1 - 0.011 14.0 0.0 0.2 9.8 0.0 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain SGL PF08450.7 KOG98078.1 - 0.061 12.6 0.7 9.6 5.5 0.0 4.2 4 1 1 5 5 5 0 SMP-30/Gluconolaconase/LRE-like region His_Phos_2 PF00328.17 KOG98079.1 - 1.8e-132 441.9 0.2 2.4e-132 441.4 0.2 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.6 KOG98079.1 - 1.1e-08 34.7 0.0 2.3e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 KOG98079.1 - 0.034 14.0 0.1 0.17 11.7 0.1 2.2 1 1 0 1 1 1 0 ATP-grasp domain Ctr PF04145.10 KOG98080.1 - 1.8e-43 148.0 0.4 2.3e-43 147.6 0.3 1.1 1 0 0 1 1 1 1 Ctr copper transporter family DUF3010 PF11215.3 KOG98080.1 - 0.034 14.0 0.0 0.052 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3010) ATP_synt_I PF03899.10 KOG98080.1 - 1.7 8.8 8.3 19 5.4 3.6 2.3 2 0 0 2 2 2 0 ATP synthase I chain SRR1 PF07985.7 KOG98081.1 - 8.8e-14 51.1 0.0 1.6e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 SRR1 SUR7 PF06687.7 KOG98082.1 - 6.5e-12 45.4 22.9 3e-10 40.0 15.8 3.0 1 1 0 1 1 1 1 SUR7/PalI family MscL PF01741.13 KOG98082.1 - 0.053 13.6 0.3 0.47 10.6 0.0 2.6 3 0 0 3 3 3 0 Large-conductance mechanosensitive channel, MscL SUR7 PF06687.7 KOG98083.1 - 4.5e-41 140.7 14.5 5.3e-41 140.5 10.0 1.0 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.3 KOG98083.1 - 3.3 7.5 12.4 0.8 9.5 6.2 1.9 1 1 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Cation_ATPase_C PF00689.16 KOG98083.1 - 3.6 7.0 12.8 8.8 5.8 8.9 1.7 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus EAP30 PF04157.11 KOG98084.1 - 2.7e-41 141.1 0.9 4.2e-41 140.5 0.6 1.3 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.3 KOG98084.1 - 3.4e-33 113.3 0.1 1.5e-32 111.2 0.0 2.2 2 0 0 2 2 2 1 Vacuolar protein sorting protein 36 Vps36 zf-Sec23_Sec24 PF04810.10 KOG98084.1 - 0.04 13.4 5.6 0.054 13.0 0.1 2.6 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger DZR PF12773.2 KOG98084.1 - 0.66 9.8 7.2 2.1 8.2 1.4 2.2 1 1 1 2 2 2 0 Double zinc ribbon Rubredoxin PF00301.15 KOG98084.1 - 4.7 7.1 9.0 0.68 9.8 0.1 3.3 3 1 1 4 4 4 0 Rubredoxin zf-RanBP PF00641.13 KOG98084.1 - 10 5.3 13.7 1.5 8.0 0.3 2.9 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others CDC73 PF05179.9 KOG98085.1 - 4.6e-87 291.8 0.0 7.7e-87 291.1 0.0 1.3 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family OB_NTP_bind PF07717.11 KOG98086.1 - 1.7e-22 79.3 0.0 8.7e-22 77.1 0.0 2.3 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold RWD PF05773.17 KOG98086.1 - 2.5e-13 49.9 1.9 1.1e-12 47.7 1.3 2.3 1 0 0 1 1 1 1 RWD domain Helicase_C PF00271.26 KOG98086.1 - 3.3e-11 42.8 0.2 1.2e-10 41.0 0.1 2.1 2 0 0 2 2 1 1 Helicase conserved C-terminal domain HA2 PF04408.18 KOG98086.1 - 4.4e-10 39.4 1.3 1.3e-09 37.9 0.0 2.6 2 0 0 2 2 1 1 Helicase associated domain (HA2) DEAD PF00270.24 KOG98086.1 - 6.3e-10 38.8 1.8 6.3e-10 38.8 1.2 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KOG98086.1 - 7.7e-05 22.8 0.3 0.00038 20.5 0.1 2.3 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 KOG98086.1 - 0.00014 20.9 0.1 0.00043 19.2 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein PhoH PF02562.11 KOG98086.1 - 0.00014 21.1 1.8 0.00048 19.4 1.3 1.8 1 1 0 1 1 1 1 PhoH-like protein AAA_29 PF13555.1 KOG98086.1 - 0.00051 19.5 0.0 0.0011 18.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain NACHT PF05729.7 KOG98086.1 - 0.00054 19.6 0.1 0.0019 17.9 0.1 2.0 1 0 0 1 1 1 1 NACHT domain UBA PF00627.26 KOG98086.1 - 0.00054 19.7 0.2 0.0012 18.6 0.1 1.6 1 0 0 1 1 1 1 UBA/TS-N domain AAA_16 PF13191.1 KOG98086.1 - 0.00085 19.3 0.1 0.016 15.2 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 KOG98086.1 - 0.0011 18.6 0.0 0.0025 17.5 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 KOG98086.1 - 0.0021 17.5 0.0 0.0047 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 KOG98086.1 - 0.0023 17.4 0.0 0.0051 16.3 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_10 PF12846.2 KOG98086.1 - 0.0079 15.6 0.5 5.5 6.3 0.0 3.0 3 0 0 3 3 3 2 AAA-like domain Zot PF05707.7 KOG98086.1 - 0.009 15.5 0.1 0.049 13.1 0.1 2.3 2 1 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_23 PF13476.1 KOG98086.1 - 0.018 15.3 0.0 0.018 15.3 0.0 4.6 3 2 0 3 3 2 0 AAA domain KaiC PF06745.8 KOG98086.1 - 0.028 13.5 4.3 0.029 13.4 0.0 2.8 3 0 0 3 3 3 0 KaiC ABC_tran PF00005.22 KOG98086.1 - 0.064 13.5 0.9 0.28 11.4 0.0 2.6 2 1 0 2 2 2 0 ABC transporter Amidohydro_4 PF13147.1 KOG98087.1 - 8e-09 35.9 0.0 1e-08 35.5 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_2 PF04909.9 KOG98087.1 - 4.6e-06 26.4 0.1 1e-05 25.2 0.1 1.7 1 1 0 1 1 1 1 Amidohydrolase Proteasom_Rpn13 PF04683.8 KOG98088.1 - 9.7e-21 73.6 0.0 1.3e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor Ded_cyto PF06920.8 KOG98089.1 - 1.3e-22 79.9 0.0 2.9e-22 78.8 0.0 1.6 1 0 0 1 1 1 1 Dedicator of cytokinesis APG17 PF04108.7 KOG98090.1 - 2.7e-112 375.6 23.1 3e-112 375.4 16.0 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 DCP2 PF05026.8 KOG98090.1 - 0.047 13.5 0.0 0.16 11.9 0.0 1.9 1 0 0 1 1 1 0 Dcp2, box A domain DUF2675 PF11247.3 KOG98090.1 - 0.11 12.6 0.5 0.37 10.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2675) MtrB PF05440.7 KOG98090.1 - 0.12 12.4 0.4 0.38 10.8 0.0 2.0 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B FTO_CTD PF12934.2 KOG98090.1 - 0.38 10.2 4.8 1.7 8.2 0.0 3.1 4 0 0 4 4 4 0 FTO C-terminal domain Reo_sigmaC PF04582.7 KOG98090.1 - 0.68 9.0 5.3 15 4.5 0.2 3.2 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.7 KOG98090.1 - 0.94 9.3 21.9 1.1 9.1 0.3 4.7 2 1 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.7 KOG98090.1 - 4.7 7.0 18.2 5.9 6.7 1.6 4.3 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) G-patch PF01585.18 KOG98091.1 - 5.5e-13 48.4 1.2 1e-12 47.6 0.8 1.5 1 0 0 1 1 1 1 G-patch domain GCFC PF07842.7 KOG98091.1 - 3.9e-08 32.9 1.8 7.1e-08 32.1 1.2 1.4 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein G-patch_2 PF12656.2 KOG98091.1 - 2e-05 24.3 0.1 4.6e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 DExH-box splicing factor binding site DUF3741 PF12552.3 KOG98091.1 - 0.31 10.7 5.2 4.4 7.1 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3741) CNH PF00780.17 KOG98092.1 - 3.7e-15 56.0 1.7 1.8e-14 53.8 1.2 2.0 1 1 0 1 1 1 1 CNH domain PH PF00169.24 KOG98092.1 - 5.3e-15 55.5 5.3 5.9e-15 55.3 0.1 3.1 2 1 0 2 2 2 1 PH domain RhoGEF PF00621.15 KOG98092.1 - 1.2e-07 31.7 0.1 4.9e-07 29.8 0.1 2.1 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.1 KOG98092.1 - 3.6e-06 26.9 0.3 1.7e-05 24.7 0.2 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain SRP9-21 PF05486.7 KOG98092.1 - 0.024 14.3 0.1 0.073 12.8 0.1 1.8 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) zf-RING_5 PF14634.1 KOG98093.1 - 4.1e-07 29.6 6.1 7.8e-07 28.7 4.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 KOG98093.1 - 1.3e-06 28.1 4.3 2.3e-06 27.3 3.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 KOG98093.1 - 2.2e-06 27.2 5.5 5.1e-06 26.0 3.8 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOG98093.1 - 5e-06 26.4 7.1 9.8e-06 25.5 4.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOG98093.1 - 7.2e-06 25.5 3.5 1.4e-05 24.6 2.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOG98093.1 - 0.0012 18.5 2.8 0.0031 17.1 2.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 KOG98093.1 - 0.0087 15.9 7.6 0.032 14.0 5.2 2.0 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.3 KOG98093.1 - 0.22 11.0 3.4 0.5 9.9 2.4 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FYVE PF01363.16 KOG98093.1 - 1.2 9.0 3.7 4.1 7.3 2.6 1.9 1 1 0 1 1 1 0 FYVE zinc finger zf-MIZ PF02891.15 KOG98093.1 - 2.8 7.5 5.9 9.9 5.7 4.1 1.9 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger DUF2951 PF11166.3 KOG98093.1 - 6.3 6.7 8.0 0.44 10.4 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2951) DUF1900 PF08954.6 KOG98094.1 - 5.3e-49 165.2 0.0 3.7e-48 162.4 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1900) DUF1899 PF08953.6 KOG98094.1 - 1.7e-31 107.6 0.2 3e-31 106.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.27 KOG98094.1 - 5.3e-24 83.1 5.3 1.3e-06 28.0 0.0 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.3 KOG98094.1 - 4.1e-05 21.9 0.2 0.0011 17.1 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.6 KOG98094.1 - 0.00026 20.7 0.1 0.066 12.9 0.0 2.9 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A SEN1_N PF12726.2 KOG98095.1 - 2.3e-232 773.1 19.3 3.3e-232 772.6 13.3 1.2 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.1 KOG98095.1 - 3.5e-67 226.4 0.1 3.5e-67 226.4 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA_12 PF13087.1 KOG98095.1 - 9.6e-63 211.1 0.0 3.2e-62 209.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOG98095.1 - 1.2e-10 41.0 0.0 3.7e-10 39.4 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 KOG98095.1 - 9.9e-07 28.5 0.0 0.0013 18.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain CHASE3 PF05227.8 KOG98095.1 - 0.026 14.2 0.5 0.088 12.4 0.4 1.9 1 0 0 1 1 1 0 CHASE3 domain UvrD_C_2 PF13538.1 KOG98095.1 - 0.14 12.3 0.3 0.6 10.2 0.0 2.3 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain Ribosomal_L29 PF00831.18 KOG98096.1 - 6.3 6.5 12.5 5.6 6.7 0.8 4.8 5 0 0 5 5 5 0 Ribosomal L29 protein IMPDH PF00478.20 KOG98097.1 - 7.3e-143 475.6 1.2 8.7e-143 475.4 0.8 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 KOG98097.1 - 7.8e-15 54.3 0.0 5.9e-07 29.1 0.0 2.5 2 0 0 2 2 2 2 CBS domain NMO PF03060.10 KOG98097.1 - 1.4e-07 31.0 0.8 9.8e-05 21.6 0.4 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.13 KOG98097.1 - 1.1e-06 27.7 0.5 3.1e-06 26.2 0.4 1.7 1 1 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 KOG98097.1 - 0.00044 19.5 0.8 0.018 14.3 0.1 2.3 1 1 1 2 2 2 1 Histidine biosynthesis protein Response_reg PF00072.19 KOG98097.1 - 0.012 15.5 0.0 0.049 13.6 0.0 2.0 2 0 0 2 2 2 0 Response regulator receiver domain ThiG PF05690.9 KOG98097.1 - 0.14 11.2 1.3 0.17 10.9 0.2 1.7 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG Metallophos PF00149.23 KOG98098.1 - 1.6e-39 135.3 0.1 2.3e-39 134.8 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase WGG PF10273.4 KOG98099.1 - 3.9e-32 110.1 0.6 3.9e-32 110.1 0.4 2.1 2 1 0 2 2 1 1 Pre-rRNA-processing protein TSR2 RXT2_N PF08595.6 KOG98099.1 - 0.0091 15.8 7.9 0.014 15.1 5.5 1.2 1 0 0 1 1 1 1 RXT2-like, N-terminal Nucleoplasmin PF03066.10 KOG98099.1 - 0.011 15.2 9.4 0.015 14.8 6.5 1.3 1 0 0 1 1 1 0 Nucleoplasmin DUF2457 PF10446.4 KOG98099.1 - 0.012 14.4 14.2 0.014 14.1 9.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.1 KOG98099.1 - 0.032 14.5 13.0 0.087 13.1 9.0 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sigma70_ner PF04546.8 KOG98099.1 - 0.035 13.7 6.6 0.05 13.2 4.6 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Vfa1 PF08432.5 KOG98099.1 - 0.048 13.6 5.1 0.085 12.8 3.5 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF446 PF04287.7 KOG98099.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 tRNA pseudouridine synthase C Cwf_Cwc_15 PF04889.7 KOG98099.1 - 0.21 11.2 7.4 0.28 10.8 5.2 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.9 KOG98099.1 - 0.28 9.1 5.7 0.32 8.9 4.0 1.1 1 0 0 1 1 1 0 CDC45-like protein AAA_28 PF13521.1 KOG98099.1 - 0.42 10.5 2.2 0.55 10.1 1.5 1.5 1 1 0 1 1 1 0 AAA domain FAM176 PF14851.1 KOG98099.1 - 0.46 10.1 4.0 0.79 9.3 2.8 1.3 1 0 0 1 1 1 0 FAM176 family CDC27 PF09507.5 KOG98099.1 - 0.93 8.6 7.2 1.4 8.0 5.0 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Voldacs PF03517.8 KOG98099.1 - 1.3 8.8 8.5 2.7 7.8 5.9 1.6 1 1 0 1 1 1 0 Regulator of volume decrease after cellular swelling NOA36 PF06524.7 KOG98099.1 - 1.7 7.8 8.9 2.2 7.4 6.2 1.1 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.5 KOG98099.1 - 2.3 8.5 13.8 2.7 8.3 8.1 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FAM178 PF14816.1 KOG98099.1 - 3.5 6.2 5.3 4.6 5.8 3.7 1.1 1 0 0 1 1 1 0 Family of unknown function, FAM178 Tom22 PF04281.8 KOG98099.1 - 7.1 6.1 10.3 14 5.2 7.1 1.4 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Hid1 PF12722.2 KOG98100.1 - 1.8e-247 823.4 52.1 2.1e-247 823.2 36.1 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein RNR_inhib PF08591.5 KOG98101.1 - 6e-19 68.7 0.2 6e-19 68.7 0.1 1.7 2 0 0 2 2 2 1 Ribonucleotide reductase inhibitor Aminotran_3 PF00202.16 KOG98102.1 - 4.2e-108 361.2 0.0 4.9e-108 360.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 KOG98102.1 - 0.00032 19.9 0.0 0.0007 18.8 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 KOG98102.1 - 0.0061 15.5 0.0 0.028 13.3 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class I and II LSM PF01423.17 KOG98103.1 - 2e-19 68.9 0.1 2.5e-19 68.6 0.1 1.1 1 0 0 1 1 1 1 LSM domain SH3_9 PF14604.1 KOG98103.1 - 0.1 12.1 0.2 1.4 8.5 0.0 2.2 2 0 0 2 2 2 0 Variant SH3 domain MRP-L47 PF06984.8 KOG98104.1 - 3.9e-27 93.9 0.2 9e-27 92.8 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Thioredoxin_5 PF13743.1 KOG98104.1 - 0.067 12.7 0.9 4.4 6.8 0.1 2.2 1 1 1 2 2 2 0 Thioredoxin Sec39 PF08314.6 KOG98105.1 - 5.9e-156 520.3 16.2 6.7e-156 520.1 11.2 1.0 1 0 0 1 1 1 1 Secretory pathway protein Sec39 DUF4206 PF13901.1 KOG98105.1 - 0.022 14.3 1.0 0.061 12.8 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) Ribosomal_S3Ae PF01015.13 KOG98106.1 - 6.1e-80 267.1 7.3 7.1e-80 266.9 5.1 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Inhibitor_I9 PF05922.11 KOG98106.1 - 0.077 13.5 0.1 0.24 12.0 0.0 1.8 1 1 0 1 1 1 0 Peptidase inhibitor I9 Abhydro_lipase PF04083.11 KOG98106.1 - 0.078 12.3 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region SpoVIF PF14069.1 KOG98106.1 - 0.32 10.7 2.4 7 6.4 0.6 2.5 1 1 1 2 2 2 0 Stage VI sporulation protein F DUF4234 PF14018.1 KOG98107.1 - 0.079 12.7 3.7 0.26 11.0 2.5 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) DUF912 PF06024.7 KOG98107.1 - 0.14 12.2 0.6 0.43 10.6 0.4 1.8 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Tn7_TnsC_Int PF11426.3 KOG98107.1 - 0.22 11.2 1.4 4.4 7.1 0.1 2.6 2 0 0 2 2 2 0 Tn7 transposition regulator TnsC Hexokinase_1 PF00349.16 KOG98108.1 - 2.2e-08 33.6 0.2 3.7e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 KOG98108.1 - 0.043 13.0 0.0 17 4.5 0.0 3.1 3 0 0 3 3 3 0 Hexokinase vATP-synt_AC39 PF01992.11 KOG98109.1 - 5.2e-85 285.5 0.1 5.9e-85 285.3 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Ribosomal_L6e PF01159.14 KOG98110.1 - 9.1e-39 132.0 2.5 1.2e-38 131.6 1.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L6e FKBP_C PF00254.23 KOG98111.1 - 6.9e-28 96.5 0.7 3.5e-27 94.2 0.0 2.5 3 0 0 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase Daxx PF03344.10 KOG98111.1 - 1.3 7.4 46.6 0.11 10.9 16.1 2.0 2 0 0 2 2 2 0 Daxx Family GAGA_bind PF06217.7 KOG98111.1 - 6 6.7 17.1 3.4 7.5 5.6 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family HMG-CoA_red PF00368.13 KOG98112.1 - 5.6e-157 522.1 0.2 7.2e-157 521.8 0.2 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.1 KOG98112.1 - 4.2e-40 136.9 1.7 4.2e-40 136.9 1.1 1.7 2 0 0 2 2 2 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.3 KOG98112.1 - 5.7e-08 32.3 9.0 5.7e-08 32.3 6.2 1.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Zn_clus PF00172.13 KOG98113.1 - 2.1e-08 33.9 11.1 3.8e-08 33.1 7.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CENP-B_dimeris PF09026.5 KOG98113.1 - 0.15 12.3 6.2 0.35 11.1 4.3 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RGS PF00615.14 KOG98114.1 - 3.5e-20 72.2 1.5 5.9e-13 48.9 0.0 2.6 2 0 0 2 2 2 2 Regulator of G protein signaling domain DEP PF00610.16 KOG98114.1 - 2.9e-13 49.3 0.0 2.3e-11 43.2 0.0 2.5 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF1902 PF08972.6 KOG98114.1 - 0.046 13.2 0.1 0.1 12.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1902) Fmp27 PF10344.4 KOG98116.1 - 1.1e-180 602.3 50.9 2.3e-180 601.3 35.3 1.6 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Fmp27_WPPW PF10359.4 KOG98116.1 - 2.4e-125 418.6 3.8 2.4e-125 418.6 2.7 2.2 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Apt1 PF10351.4 KOG98116.1 - 8.8e-101 338.0 14.3 7.9e-70 235.9 4.9 3.1 2 1 1 3 3 3 2 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.4 KOG98116.1 - 1.5e-58 197.1 0.1 3.8e-58 195.8 0.1 1.8 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.4 KOG98116.1 - 3.5e-51 173.0 5.0 1.6e-50 170.9 3.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.4 KOG98116.1 - 1.2e-34 118.8 0.0 9.8e-34 115.8 0.0 2.8 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain PWWP PF00855.12 KOG98117.1 - 1.8e-16 60.1 0.1 1.8e-16 60.1 0.1 2.2 2 1 0 2 2 2 1 PWWP domain Ycf54 PF10674.4 KOG98117.1 - 0.016 15.3 0.6 0.041 14.0 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2488) Pyridox_oxidase PF01243.15 KOG98118.1 - 4.6e-12 45.7 0.0 1.7e-11 43.9 0.0 1.9 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 KOG98118.1 - 0.13 12.0 0.0 2.4 7.9 0.0 2.1 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase NBP1 PF08537.5 KOG98119.1 - 1.9e-98 329.6 22.5 2.1e-98 329.4 15.6 1.0 1 0 0 1 1 1 1 Fungal Nap binding protein NBP1 DUF4140 PF13600.1 KOG98119.1 - 0.41 11.1 2.7 0.66 10.4 0.7 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) PIG-U PF06728.8 KOG98120.1 - 8.1e-105 350.7 44.9 9.8e-105 350.5 31.1 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U SRP1_TIP1 PF00660.12 KOG98121.1 - 4.2e-32 110.0 0.1 5.2e-32 109.7 0.1 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family Acetyltransf_3 PF13302.1 KOG98122.1 - 2.1e-16 60.3 0.0 3.1e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 KOG98122.1 - 3.8e-07 30.1 0.0 5.7e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 KOG98122.1 - 0.0033 17.3 0.0 0.005 16.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Viral_cys_rich PF08008.7 KOG98122.1 - 0.022 14.3 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 Viral cysteine rich Sugar_tr PF00083.19 KOG98125.1 - 2.4e-70 237.3 23.3 2.8e-70 237.1 16.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG98125.1 - 2.2e-24 85.8 33.8 2.2e-24 85.8 23.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily DHO_dh PF01180.16 KOG98126.1 - 1.5e-96 322.8 0.0 1.7e-96 322.6 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.13 KOG98126.1 - 2.9e-05 23.0 0.0 0.00088 18.2 0.0 2.1 2 0 0 2 2 2 1 FMN-dependent dehydrogenase Polysacc_deac_1 PF01522.16 KOG98126.1 - 0.0071 15.9 0.0 0.037 13.6 0.0 2.0 2 1 0 2 2 2 1 Polysaccharide deacetylase Glu_synthase PF01645.12 KOG98126.1 - 0.035 13.0 0.0 0.054 12.4 0.0 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase NMO PF03060.10 KOG98126.1 - 0.061 12.4 0.1 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase DUF885 PF05960.6 KOG98126.1 - 0.083 12.0 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) PcrB PF01884.12 KOG98126.1 - 0.096 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 PcrB family RRM_1 PF00076.17 KOG98127.1 - 4.8e-07 29.3 0.0 7.1e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG98127.1 - 2.2e-05 24.3 0.0 3.5e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 KOG98127.1 - 3.3e-05 24.2 6.7 0.00023 21.5 4.6 2.2 1 1 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 RRM_5 PF13893.1 KOG98127.1 - 0.00087 19.0 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HCNGP PF07818.8 KOG98127.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 HCNGP-like protein PUL PF08324.6 KOG98128.1 - 3.7e-64 216.1 0.6 5.1e-64 215.6 0.4 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.6 KOG98128.1 - 5.3e-44 148.9 0.1 1.6e-43 147.3 0.0 1.9 2 0 0 2 2 2 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.27 KOG98128.1 - 2.6e-38 128.5 14.5 8.4e-09 34.9 0.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat BBS2_Mid PF14783.1 KOG98128.1 - 3.6e-06 26.7 1.3 0.43 10.3 0.0 4.2 4 1 0 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Sialidase PF02973.11 KOG98128.1 - 0.005 15.8 0.0 0.011 14.7 0.0 1.5 1 0 0 1 1 1 1 Sialidase, N-terminal domain Nup160 PF11715.3 KOG98128.1 - 0.0086 14.2 3.8 2.4 6.1 0.1 3.5 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Syja_N PF02383.13 KOG98129.1 - 1.8e-86 289.8 2.0 2.3e-86 289.4 1.4 1.1 1 0 0 1 1 1 1 SacI homology domain IGPS PF00218.16 KOG98130.1 - 1e-97 326.2 0.0 1.2e-97 325.9 0.0 1.1 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase GATase PF00117.23 KOG98130.1 - 1.5e-55 187.6 0.0 2.4e-55 186.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 KOG98130.1 - 1.2e-10 41.1 0.0 2.6e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.14 KOG98130.1 - 6.1e-05 22.6 0.1 0.00012 21.6 0.0 1.4 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.16 KOG98130.1 - 0.062 12.5 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein RimM PF01782.13 KOG98130.1 - 0.085 12.7 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 RimM N-terminal domain ThiF PF00899.16 KOG98131.1 - 1.3e-51 173.9 0.4 5.6e-31 107.1 0.0 2.6 2 0 0 2 2 2 2 ThiF family UBA_e1_C PF09358.5 KOG98131.1 - 5.5e-43 146.0 0.1 1.3e-42 144.8 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-activating enzyme e1 C-terminal domain UBACT PF02134.16 KOG98131.1 - 3.8e-33 112.8 3.5 6.4e-23 80.0 0.2 3.0 3 0 0 3 3 3 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 KOG98131.1 - 3.5e-27 93.5 0.4 1e-20 72.7 0.1 2.5 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site ABC_membrane PF00664.18 KOG98132.1 - 6.5e-93 311.1 38.1 6.6e-47 160.2 11.8 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 KOG98132.1 - 1.4e-62 209.9 0.1 5.4e-32 110.9 0.0 2.9 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 KOG98132.1 - 1.7e-18 66.6 0.7 6.1e-08 32.1 0.0 4.3 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 KOG98132.1 - 4.8e-08 32.4 0.8 0.002 17.5 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.4 KOG98132.1 - 8.5e-08 31.2 0.0 0.01 14.4 0.0 3.0 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_10 PF12846.2 KOG98132.1 - 3e-07 30.1 2.4 0.023 14.1 0.1 3.6 3 0 0 3 3 3 2 AAA-like domain AAA_17 PF13207.1 KOG98132.1 - 3.3e-07 31.1 0.0 0.033 15.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 KOG98132.1 - 1.6e-06 27.4 0.1 0.011 14.9 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 DUF87 PF01935.12 KOG98132.1 - 2e-06 27.8 1.7 0.0012 18.6 0.0 3.2 3 1 0 3 3 3 1 Domain of unknown function DUF87 AAA_22 PF13401.1 KOG98132.1 - 2.1e-06 27.9 2.0 0.077 13.1 0.1 4.0 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.1 KOG98132.1 - 6.2e-06 26.5 0.0 0.2 11.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 KOG98132.1 - 1.1e-05 25.5 1.2 0.021 14.7 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.9 KOG98132.1 - 8.2e-05 22.3 0.0 0.28 10.9 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 KOG98132.1 - 0.0001 21.7 0.0 0.077 12.3 0.0 2.7 3 0 0 3 3 2 1 AAA domain DUF3987 PF13148.1 KOG98132.1 - 0.00047 18.8 0.0 0.12 10.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) Zeta_toxin PF06414.7 KOG98132.1 - 0.00056 19.0 0.0 0.48 9.4 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin MMR_HSR1 PF01926.18 KOG98132.1 - 0.001 19.0 1.6 0.74 9.7 0.2 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_33 PF13671.1 KOG98132.1 - 0.003 17.4 0.0 1 9.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 KOG98132.1 - 0.0038 16.9 0.1 2.6 7.7 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B ATP-synt_ab PF00006.20 KOG98132.1 - 0.0041 16.6 0.0 1.6 8.1 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain APS_kinase PF01583.15 KOG98132.1 - 0.0055 16.3 0.2 4.8 6.8 0.0 2.7 2 0 0 2 2 2 0 Adenylylsulphate kinase T2SE PF00437.15 KOG98132.1 - 0.0078 15.1 0.0 0.64 8.8 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein NB-ARC PF00931.17 KOG98132.1 - 0.0089 14.9 0.0 2.4 6.9 0.0 2.7 2 0 0 2 2 2 1 NB-ARC domain CbiA PF01656.18 KOG98132.1 - 0.012 15.0 0.0 5.7 6.2 0.0 2.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain FtsK_SpoIIIE PF01580.13 KOG98132.1 - 0.016 14.6 0.2 5.1 6.5 0.0 3.0 3 0 0 3 3 3 0 FtsK/SpoIIIE family RNA_helicase PF00910.17 KOG98132.1 - 0.022 14.9 0.0 7.6 6.7 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_23 PF13476.1 KOG98132.1 - 0.037 14.3 8.7 0.42 10.9 0.1 3.4 3 0 0 3 3 3 0 AAA domain KaiC PF06745.8 KOG98132.1 - 0.047 12.8 2.8 2.8 7.0 0.0 3.5 4 0 0 4 4 4 0 KaiC AAA_21 PF13304.1 KOG98132.1 - 0.049 13.5 21.9 0.77 9.6 3.7 4.9 3 2 0 4 4 3 0 AAA domain NACHT PF05729.7 KOG98132.1 - 0.075 12.6 1.9 12 5.5 0.0 3.5 3 0 0 3 3 3 0 NACHT domain SbcCD_C PF13558.1 KOG98132.1 - 0.13 12.1 1.0 15 5.6 0.2 3.2 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_13 PF13166.1 KOG98132.1 - 3 6.1 15.5 0.12 10.8 1.3 3.2 4 0 0 4 4 3 0 AAA domain DUF106 PF01956.11 KOG98134.1 - 6.6e-50 168.9 2.7 8.9e-50 168.4 1.9 1.2 1 0 0 1 1 1 1 Integral membrane protein DUF106 PAC2 PF09754.4 KOG98135.1 - 1e-26 94.1 0.0 1.3e-26 93.8 0.0 1.1 1 0 0 1 1 1 1 PAC2 family FAT PF02259.18 KOG98137.1 - 2e-134 448.0 2.2 2e-134 448.0 1.5 3.2 4 0 0 4 4 4 1 FAT domain DUF3385 PF11865.3 KOG98137.1 - 9.8e-65 217.3 6.8 1.8e-63 213.2 0.1 4.7 5 0 0 5 5 4 1 Domain of unknown function (DUF3385) PI3_PI4_kinase PF00454.22 KOG98137.1 - 8.8e-61 205.3 0.2 1.9e-60 204.2 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Rapamycin_bind PF08771.6 KOG98137.1 - 8.5e-43 144.5 3.3 4.2e-42 142.3 0.4 3.1 2 0 0 2 2 2 1 Rapamycin binding domain FATC PF02260.15 KOG98137.1 - 2.8e-19 68.2 0.2 6.8e-19 67.0 0.2 1.7 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.1 KOG98137.1 - 6.9e-16 58.3 6.3 0.058 13.6 0.0 9.0 6 2 2 8 8 8 5 HEAT repeats HEAT_EZ PF13513.1 KOG98137.1 - 4.8e-10 39.6 1.1 0.049 14.1 0.0 9.0 6 2 3 10 10 10 2 HEAT-like repeat HEAT PF02985.17 KOG98137.1 - 2.1e-08 33.5 1.8 0.064 13.3 0.0 7.8 8 0 0 8 8 8 1 HEAT repeat Vac14_Fab1_bd PF12755.2 KOG98137.1 - 0.02 15.2 2.9 0.6 10.5 0.0 4.4 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region TPR_19 PF14559.1 KOG98137.1 - 0.038 14.3 3.7 0.3 11.4 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOG98137.1 - 0.13 12.9 1.0 25 5.6 0.2 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat LicD PF04991.8 KOG98138.1 - 3.9e-51 174.0 3.8 3.9e-51 174.0 2.6 6.2 5 2 1 6 6 6 1 LicD family Pkinase PF00069.20 KOG98139.1 - 3.7e-36 124.6 0.0 5.6e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98139.1 - 2.8e-13 49.5 0.0 3.9e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG98139.1 - 6.7e-05 21.9 0.0 0.0001 21.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG98139.1 - 0.0026 16.8 0.0 0.0045 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AAA PF00004.24 KOG98140.1 - 4.8e-50 169.1 0.0 6.3e-43 146.1 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.6 KOG98140.1 - 1.1e-21 76.6 0.1 2.9e-21 75.3 0.0 1.8 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.1 KOG98140.1 - 5.4e-12 46.0 0.1 4.5e-05 23.5 0.0 3.4 2 1 1 3 3 3 2 AAA ATPase domain AAA_14 PF13173.1 KOG98140.1 - 6.4e-10 39.0 0.1 0.00037 20.3 0.0 3.4 3 0 0 3 3 3 2 AAA domain NACHT PF05729.7 KOG98140.1 - 1.7e-07 31.0 1.2 0.0032 17.1 0.0 4.3 5 0 0 5 5 4 2 NACHT domain AAA_22 PF13401.1 KOG98140.1 - 7.2e-07 29.4 0.2 0.11 12.6 0.0 3.9 2 2 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 KOG98140.1 - 2.5e-06 27.6 0.0 1.1 9.4 0.0 3.9 3 0 0 3 3 3 2 RNA helicase Arch_ATPase PF01637.13 KOG98140.1 - 2e-05 24.4 1.2 0.021 14.5 0.0 3.8 2 2 2 4 4 4 1 Archaeal ATPase AAA_17 PF13207.1 KOG98140.1 - 2e-05 25.3 0.0 0.012 16.4 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 KOG98140.1 - 2.2e-05 24.1 0.0 0.34 10.6 0.0 3.8 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 KOG98140.1 - 0.00017 21.0 0.0 1.6 8.0 0.1 3.6 2 2 1 3 3 3 1 AAA domain AAA_2 PF07724.9 KOG98140.1 - 0.00043 20.2 0.0 0.01 15.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.1 KOG98140.1 - 0.00051 20.3 0.4 0.62 10.3 0.0 3.4 4 0 0 4 4 2 1 AAA domain Zeta_toxin PF06414.7 KOG98140.1 - 0.00073 18.6 0.0 0.18 10.8 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_33 PF13671.1 KOG98140.1 - 0.00079 19.3 0.0 0.067 13.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 KOG98140.1 - 0.0011 18.1 0.0 0.0057 15.7 0.0 2.2 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus ATP-synt_ab PF00006.20 KOG98140.1 - 0.0038 16.7 0.0 0.038 13.4 0.0 2.2 1 1 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_19 PF13245.1 KOG98140.1 - 0.004 16.8 0.0 2 8.2 0.0 2.5 2 0 0 2 2 2 1 Part of AAA domain IstB_IS21 PF01695.12 KOG98140.1 - 0.0067 15.8 0.0 0.2 11.0 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein UPF0079 PF02367.12 KOG98140.1 - 0.0081 15.7 0.0 1.5 8.4 0.0 2.6 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 TIP49 PF06068.8 KOG98140.1 - 0.02 13.6 0.0 0.12 11.1 0.0 2.2 2 0 0 2 2 2 0 TIP49 C-terminus AAA_3 PF07726.6 KOG98140.1 - 0.022 14.3 0.0 0.34 10.5 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 KOG98140.1 - 0.023 14.1 0.0 10 5.5 0.0 2.7 2 1 0 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.13 KOG98140.1 - 0.029 13.8 0.0 1.1 8.7 0.0 2.7 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase T2SE PF00437.15 KOG98140.1 - 0.041 12.7 0.0 0.84 8.4 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_24 PF13479.1 KOG98140.1 - 0.042 13.4 0.3 3.6 7.0 0.1 2.8 2 0 0 2 2 2 0 AAA domain Cytidylate_kin2 PF13189.1 KOG98140.1 - 0.051 13.4 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 Cytidylate kinase-like family Mg_chelatase PF01078.16 KOG98140.1 - 0.16 11.0 0.1 0.72 8.9 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Longin PF13774.1 KOG98141.1 - 3.4e-16 58.5 0.0 5.7e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.16 KOG98141.1 - 3.4e-15 55.4 1.1 5.7e-15 54.7 0.8 1.3 1 0 0 1 1 1 1 Synaptobrevin UPF0449 PF15136.1 KOG98141.1 - 0.0061 16.7 0.8 0.0097 16.0 0.6 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0449 Tbf5 PF06331.7 KOG98141.1 - 0.085 12.6 0.4 0.15 11.8 0.3 1.4 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 tRNA-synt_2b PF00587.20 KOG98142.1 - 1.2e-46 158.4 0.0 2e-46 157.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KOG98142.1 - 5.7e-19 67.8 0.3 9.1e-19 67.1 0.2 1.3 1 0 0 1 1 1 1 Anticodon binding domain Caps_assemb_Wzi PF14052.1 KOG98142.1 - 0.032 13.1 0.0 0.046 12.5 0.0 1.2 1 0 0 1 1 1 0 Capsule assembly protein Wzi LRR_4 PF12799.2 KOG98143.1 - 3.9e-37 125.2 56.4 2.6e-10 39.6 3.7 7.6 5 2 2 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOG98143.1 - 4.8e-23 80.6 64.5 1e-08 34.7 3.5 6.3 2 1 5 7 7 7 7 Leucine rich repeat LRR_1 PF00560.28 KOG98143.1 - 3.9e-11 41.3 48.1 0.05 13.6 0.1 11.7 12 0 0 12 12 12 6 Leucine Rich Repeat LRR_9 PF14580.1 KOG98143.1 - 5e-10 39.2 16.3 8.2e-07 28.7 1.0 3.4 1 1 2 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.1 KOG98143.1 - 3.3e-09 35.8 40.5 0.079 13.0 0.1 11.5 5 2 5 10 10 10 3 Leucine Rich repeat LRR_7 PF13504.1 KOG98143.1 - 2.9e-07 29.6 29.6 0.62 10.5 0.0 10.0 10 2 0 10 10 10 4 Leucine rich repeat LRR_5 PF13306.1 KOG98143.1 - 0.02 14.5 17.6 0.025 14.2 1.7 3.8 1 1 2 3 3 3 0 Leucine rich repeats (6 copies) DUF3744 PF12558.3 KOG98143.1 - 6.4 7.3 20.3 2.9 8.3 2.5 5.0 3 2 3 6 6 6 0 ATP-binding cassette cobalt transporter PP-binding PF00550.20 KOG98144.1 - 1.3e-12 47.8 0.2 1.7e-12 47.3 0.2 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.1 KOG98144.1 - 6.4e-07 29.3 0.2 9.4e-07 28.7 0.1 1.3 1 0 0 1 1 1 1 Acyl-carrier DUF1493 PF07377.7 KOG98144.1 - 8.9e-05 22.5 0.3 0.00014 21.9 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1493) Diphthamide_syn PF01866.12 KOG98145.1 - 5e-44 150.7 0.1 5.6e-21 75.0 0.0 2.1 2 0 0 2 2 2 2 Putative diphthamide synthesis protein EF-hand_1 PF00036.27 KOG98146.1 - 5.3e-23 78.5 15.6 3.1e-05 22.9 0.7 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOG98146.1 - 4.5e-19 68.3 4.5 1.7e-09 37.6 1.4 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOG98146.1 - 5.1e-19 66.3 6.7 0.00033 20.3 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOG98146.1 - 4.6e-14 51.0 21.1 0.0033 16.7 0.4 4.6 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.1 KOG98146.1 - 2.2e-09 36.7 17.0 0.014 14.9 0.2 4.5 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.2 KOG98146.1 - 2.5e-06 27.1 9.7 0.02 14.6 0.2 4.0 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOG98146.1 - 3.8e-05 23.6 0.0 0.14 12.1 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOG98146.1 - 0.00036 20.3 0.0 0.86 9.5 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain Mo25 PF08569.6 KOG98147.1 - 2.3e-124 414.8 9.5 2.6e-124 414.6 6.6 1.0 1 0 0 1 1 1 1 Mo25-like DUF1436 PF07262.6 KOG98147.1 - 0.01 15.3 0.6 0.019 14.4 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1436) YqbF PF14553.1 KOG98147.1 - 0.096 12.3 0.0 0.63 9.7 0.1 2.3 2 0 0 2 2 2 0 YqbF, hypothetical protein domain ABC_membrane_2 PF06472.10 KOG98148.1 - 3.8e-77 259.1 7.2 5.3e-77 258.7 5.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 KOG98148.1 - 1.1e-16 61.4 0.0 3.2e-15 56.6 0.0 2.6 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 KOG98148.1 - 0.00027 21.0 0.0 0.00027 21.0 0.0 4.0 5 0 0 5 5 5 1 AAA domain AAA_16 PF13191.1 KOG98148.1 - 0.0068 16.4 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 KOG98148.1 - 0.013 14.9 0.0 0.034 13.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.11 KOG98148.1 - 0.062 12.4 0.0 0.19 10.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOG98148.1 - 0.077 13.1 0.0 0.26 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 KOG98148.1 - 0.13 11.3 0.0 0.29 10.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SUR7 PF06687.7 KOG98149.1 - 3.8e-16 59.2 9.3 3e-15 56.3 6.5 2.2 1 1 0 1 1 1 1 SUR7/PalI family HEAT_2 PF13646.1 KOG98149.1 - 0.0009 19.4 0.9 6.7 7.0 0.0 4.2 3 1 1 4 4 4 2 HEAT repeats nsp7 PF08716.5 KOG98149.1 - 0.069 13.5 6.1 3.8 7.9 0.0 3.8 2 1 1 3 3 3 0 nsp7 replicase Mtr2 PF10429.4 KOG98150.1 - 3.1e-80 267.7 0.1 3.8e-80 267.4 0.1 1.0 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 GATA PF00320.22 KOG98151.1 - 7.4e-10 38.0 8.9 2e-09 36.6 6.1 1.8 1 0 0 1 1 1 1 GATA zinc finger Orn_Arg_deC_N PF02784.11 KOG98152.1 - 6.2e-78 261.4 0.0 8e-78 261.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 KOG98152.1 - 3.3e-31 107.4 0.2 8.1e-31 106.1 0.2 1.7 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Voldacs PF03517.8 KOG98153.1 - 2.8e-17 62.8 0.0 4.2e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling Acyl_transf_1 PF00698.16 KOG98154.1 - 1.1e-103 346.9 0.0 2e-102 342.8 0.0 3.0 4 0 0 4 4 4 1 Acyl transferase domain MaoC_dehydratas PF01575.14 KOG98154.1 - 4.7e-39 132.5 0.0 9.2e-39 131.6 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain DUF1729 PF08354.5 KOG98154.1 - 4.8e-29 99.9 0.1 1.4e-28 98.4 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) MaoC_dehydrat_N PF13452.1 KOG98154.1 - 9.1e-16 57.8 0.0 2.9e-15 56.1 0.0 1.9 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase NMO PF03060.10 KOG98154.1 - 0.0051 15.9 0.0 0.013 14.6 0.0 1.7 1 0 0 1 1 1 1 Nitronate monooxygenase Pribosyl_synth PF14572.1 KOG98155.1 - 3.2e-40 137.8 1.2 9e-32 110.3 0.1 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 KOG98155.1 - 1.3e-39 134.4 0.0 6.7e-39 132.2 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 KOG98155.1 - 4.1e-07 29.7 0.2 1.3e-05 24.9 0.1 2.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Ribosomal_L22 PF00237.14 KOG98156.1 - 3.5e-33 113.6 0.1 3.5e-33 113.6 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e Fis1_TPR_C PF14853.1 KOG98156.1 - 0.12 12.2 0.0 11 6.0 0.0 2.5 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat CASP_C PF08172.7 KOG98157.1 - 1.1e-75 253.9 2.0 1.1e-75 253.9 1.4 4.5 2 1 2 4 4 4 1 CASP C terminal UBN2_3 PF14244.1 KOG98157.1 - 0.0088 15.6 1.9 0.0088 15.6 1.3 4.1 4 2 1 5 5 5 1 gag-polypeptide of LTR copia-type DUF904 PF06005.7 KOG98157.1 - 0.35 11.2 0.0 0.35 11.2 0.0 8.6 4 2 3 7 7 7 0 Protein of unknown function (DUF904) Mnd1 PF03962.10 KOG98157.1 - 4 7.0 61.5 0.095 12.3 9.1 5.4 2 1 3 5 5 5 0 Mnd1 family DUF1515 PF07439.6 KOG98157.1 - 7.1 6.4 10.0 0.22 11.3 0.3 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1515) Seadorna_VP6 PF07407.6 KOG98157.1 - 7.5 5.1 7.3 1.7 7.2 0.2 2.6 3 0 0 3 3 3 0 Seadornavirus VP6 protein STE3 PF02076.10 KOG98158.1 - 1.2e-98 329.6 19.3 1.5e-98 329.4 13.4 1.1 1 0 0 1 1 1 1 Pheromone A receptor Zip PF02535.17 KOG98160.1 - 4.5e-27 94.8 17.9 1.3e-18 67.1 2.3 2.9 2 1 1 3 3 3 2 ZIP Zinc transporter AA_permease PF00324.16 KOG98161.1 - 1.1e-100 337.2 42.5 1.4e-100 336.9 29.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG98161.1 - 2.8e-34 118.4 47.8 3.8e-34 117.9 33.1 1.0 1 0 0 1 1 1 1 Amino acid permease GTP_EFTU PF00009.22 KOG98162.1 - 1.9e-34 118.7 0.2 3.9e-34 117.7 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 KOG98162.1 - 8.6e-15 54.6 0.0 2.1e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_C PF00679.19 KOG98162.1 - 4.2e-13 48.9 0.0 1.6e-12 47.1 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_IV PF03764.13 KOG98162.1 - 7.6e-13 48.0 0.0 1.5e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV Miro PF08477.8 KOG98162.1 - 4e-05 24.1 0.1 0.00012 22.5 0.1 1.9 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 KOG98162.1 - 0.0014 18.5 0.2 0.0034 17.3 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.1 KOG98162.1 - 0.0053 16.5 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II SRPRB PF09439.5 KOG98162.1 - 0.0078 15.4 0.1 0.21 10.7 0.0 2.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ebp2 PF05890.7 KOG98163.1 - 6.1e-86 288.0 28.1 6.1e-86 288.0 19.5 3.0 1 1 2 3 3 3 1 Eukaryotic rRNA processing protein EBP2 Pkinase PF00069.20 KOG98164.1 - 3.4e-36 124.7 1.0 4e-26 91.7 0.4 3.1 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98164.1 - 5.6e-20 71.5 0.0 3.3e-16 59.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 KOG98164.1 - 0.016 14.1 0.0 5 6.0 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Ribosomal_L14 PF00238.14 KOG98165.1 - 8.1e-39 132.1 4.1 9.1e-39 131.9 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Pkinase PF00069.20 KOG98166.1 - 1.1e-47 162.4 0.0 1.8e-47 161.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98166.1 - 1e-18 67.3 0.0 2e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase L51_S25_CI-B8 PF05047.11 KOG98167.1 - 4.6e-15 55.0 0.1 8.5e-15 54.2 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Pkinase PF00069.20 KOG98168.1 - 9.1e-73 244.5 0.0 1.1e-72 244.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98168.1 - 1.3e-40 139.1 0.0 1.7e-40 138.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG98168.1 - 8.9e-05 21.5 0.0 0.00016 20.7 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG98168.1 - 0.074 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 KOG98168.1 - 0.08 11.7 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.18 KOG98168.1 - 0.092 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOG98168.1 - 0.1 11.8 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL PigN PF04987.9 KOG98169.1 - 2.3e-137 458.2 47.5 2.9e-137 457.9 32.9 1.1 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.17 KOG98169.1 - 6e-14 52.1 1.6 4e-11 42.8 1.1 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 KOG98169.1 - 2.9e-10 39.8 0.2 5e-10 39.0 0.2 1.4 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 KOG98169.1 - 0.00074 18.9 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily PIR PF00399.14 KOG98170.1 - 1.2e-59 195.7 112.2 1e-07 31.0 4.6 9.7 9 0 0 9 9 9 8 Yeast PIR protein repeat HTH_37 PF13744.1 KOG98170.1 - 0.014 15.1 7.1 10 5.9 0.4 4.8 1 1 6 7 7 7 0 Helix-turn-helix domain HCV_NS5a_1a PF08300.8 KOG98170.1 - 0.02 14.7 1.7 35 4.4 0.0 3.9 2 1 4 6 6 6 0 Hepatitis C virus non-structural 5a zinc finger domain DUF2807 PF10988.3 KOG98170.1 - 0.082 12.4 5.6 1.8 8.0 1.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2807) DUF973 PF06157.6 KOG98170.1 - 9.4 5.1 18.6 21 3.9 2.5 3.9 1 1 3 4 4 4 0 Protein of unknown function (DUF973) PIR PF00399.14 KOG98171.1 - 1.4e-82 268.4 157.2 6.1e-08 31.7 6.0 12.7 12 0 0 12 12 12 12 Yeast PIR protein repeat DUF759 PF05537.6 KOG98171.1 - 0.014 14.2 6.1 0.55 8.9 0.7 2.4 1 1 1 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF759) PIR PF00399.14 KOG98172.1 - 3.5e-06 26.1 2.2 3.5e-06 26.1 1.5 3.0 4 0 0 4 4 4 1 Yeast PIR protein repeat SprB PF13573.1 KOG98172.1 - 0.00079 18.9 2.2 0.011 15.3 0.2 2.9 2 0 0 2 2 2 1 SprB repeat Methyltransf_28 PF02636.12 KOG98173.1 - 5.1e-16 58.8 0.0 7.3e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Pkinase PF00069.20 KOG98174.1 - 2.5e-67 226.7 0.0 3.2e-67 226.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98174.1 - 8e-30 103.7 0.0 1.2e-29 103.1 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOG98174.1 - 0.026 13.5 0.2 0.097 11.7 0.0 1.9 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family Elf1 PF05129.8 KOG98175.1 - 2e-31 107.5 2.9 2.7e-31 107.0 2.0 1.2 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like BUD22 PF09073.5 KOG98175.1 - 0.12 11.4 5.6 0.1 11.6 3.9 1.2 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.9 KOG98175.1 - 0.12 10.3 4.7 0.14 10.1 3.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_L37ae PF01780.14 KOG98175.1 - 0.12 12.2 1.3 0.19 11.6 0.9 1.3 1 0 0 1 1 1 0 Ribosomal L37ae protein family NOA36 PF06524.7 KOG98175.1 - 0.22 10.7 7.3 0.31 10.2 5.0 1.2 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.7 KOG98175.1 - 1.1 7.1 5.2 0.93 7.3 3.6 1.2 1 0 0 1 1 1 0 Nop14-like family Calcipressin PF04847.7 KOG98176.1 - 4.7e-40 137.1 0.5 7.1e-40 136.5 0.3 1.3 1 0 0 1 1 1 1 Calcipressin Ribosomal_S27e PF01667.12 KOG98177.1 - 2.1e-30 103.9 2.7 2.9e-30 103.5 1.9 1.2 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.16 KOG98177.1 - 2.7e-05 23.9 0.7 3.3e-05 23.6 0.5 1.1 1 0 0 1 1 1 1 IBR domain TF_Zn_Ribbon PF08271.7 KOG98177.1 - 0.05 12.9 3.8 0.074 12.3 2.6 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding zinc_ribbon_5 PF13719.1 KOG98177.1 - 0.13 11.9 1.3 6.2 6.5 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 KOG98177.1 - 0.14 11.8 1.3 6.3 6.5 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Rsm22 PF09243.5 KOG98178.1 - 1.4e-29 102.9 0.4 8.3e-11 41.4 0.0 4.2 3 1 0 3 3 3 3 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.1 KOG98178.1 - 6.4e-05 22.7 0.0 0.00017 21.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOG98178.1 - 0.026 15.0 0.0 0.11 13.1 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase domain SRPRB PF09439.5 KOG98179.1 - 1.9e-67 226.0 0.6 2.6e-67 225.5 0.4 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.16 KOG98179.1 - 1.2e-10 40.9 0.0 1.7e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOG98179.1 - 4e-08 33.2 0.1 8.6e-08 32.1 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOG98179.1 - 0.00021 20.6 0.2 0.00045 19.5 0.2 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 KOG98179.1 - 0.00033 20.1 0.2 0.0071 15.7 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Miro PF08477.8 KOG98179.1 - 0.0026 18.2 0.1 0.014 15.8 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein AAA_16 PF13191.1 KOG98179.1 - 0.063 13.2 0.1 0.15 12.0 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.1 KOG98179.1 - 0.076 13.3 4.5 2.9 8.1 0.2 2.2 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 KOG98179.1 - 0.14 11.9 6.3 0.77 9.5 1.7 3.2 2 1 0 2 2 2 0 Dynamin family AAA_18 PF13238.1 KOG98179.1 - 0.26 11.5 1.8 2.1 8.6 0.1 2.3 1 1 1 2 2 2 0 AAA domain Vpu PF00558.14 KOG98179.1 - 0.65 9.6 4.6 0.27 10.7 0.6 2.1 2 0 0 2 2 2 0 Vpu protein Bac_small_YrzI PF09501.5 KOG98179.1 - 1.7 8.5 4.6 23 4.9 0.3 2.6 2 0 0 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) His_Phos_1 PF00300.17 KOG98180.1 - 3.6e-43 147.4 0.0 4.4e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Carb_kinase PF01256.12 KOG98181.1 - 3.3e-86 288.5 0.0 4.4e-86 288.1 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.7 KOG98181.1 - 3.3e-06 26.4 0.0 4.5e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase NAD_binding_1 PF00175.16 KOG98182.1 - 1.7e-25 89.7 0.0 2.9e-24 85.7 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 KOG98182.1 - 3.5e-25 88.0 0.0 5.7e-25 87.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 KOG98182.1 - 0.00058 19.7 0.0 0.04 13.8 0.0 2.8 2 1 1 3 3 3 1 Ferric reductase NAD binding domain Metallophos PF00149.23 KOG98183.1 - 3.3e-15 56.0 2.7 3.3e-15 56.0 1.9 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase DBR1 PF05011.8 KOG98183.1 - 3.6e-09 36.6 0.1 6.7e-09 35.7 0.1 1.5 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Usg PF06233.7 KOG98183.1 - 0.017 14.9 0.1 0.097 12.5 0.0 2.2 2 0 0 2 2 2 0 Usg-like family FAD_binding_2 PF00890.19 KOG98184.1 - 8.1e-124 413.6 2.2 1e-123 413.2 1.5 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 KOG98184.1 - 4.4e-47 159.1 0.8 6.9e-47 158.5 0.6 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.17 KOG98184.1 - 7.7e-07 28.2 0.5 0.00061 18.7 0.3 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.9 KOG98184.1 - 8.5e-07 29.0 2.3 8.4e-05 22.5 1.3 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOG98184.1 - 8e-06 24.9 1.6 0.00011 21.2 1.1 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 KOG98184.1 - 4.8e-05 22.5 0.3 0.002 17.2 0.1 2.4 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.14 KOG98184.1 - 0.0059 15.7 1.3 0.011 14.8 0.1 2.1 3 0 0 3 3 3 1 FAD binding domain HI0933_like PF03486.9 KOG98184.1 - 0.011 14.2 0.2 0.064 11.7 0.0 2.3 3 0 0 3 3 3 0 HI0933-like protein Pyr_redox_3 PF13738.1 KOG98184.1 - 0.32 11.0 2.9 1.2 9.0 0.3 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Aa_trans PF01490.13 KOG98185.1 - 3.3e-103 345.3 30.0 4e-103 345.0 20.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AAA PF00004.24 KOG98186.1 - 3.6e-40 137.2 0.0 6.4e-40 136.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOG98186.1 - 5.5e-06 26.5 0.0 0.001 19.2 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 KOG98186.1 - 2.9e-05 23.8 0.0 0.00013 21.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOG98186.1 - 0.00015 21.8 0.0 0.00064 19.7 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.9 KOG98186.1 - 0.00022 21.1 0.0 0.00059 19.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 KOG98186.1 - 0.00085 20.1 0.2 0.003 18.3 0.0 2.2 2 1 0 2 2 1 1 AAA domain DUF815 PF05673.8 KOG98186.1 - 0.0011 17.9 0.0 0.002 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.7 KOG98186.1 - 0.0036 16.3 0.0 0.0064 15.5 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 KOG98186.1 - 0.0049 16.5 0.1 0.0095 15.6 0.1 1.4 1 0 0 1 1 1 1 Part of AAA domain AAA_28 PF13521.1 KOG98186.1 - 0.0099 15.8 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KOG98186.1 - 0.01 15.7 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOG98186.1 - 0.015 14.4 0.0 0.026 13.6 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.1 KOG98186.1 - 0.015 15.6 0.3 0.063 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 KOG98186.1 - 0.019 14.8 0.0 0.037 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOG98186.1 - 0.022 14.9 0.0 0.06 13.5 0.0 1.8 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.12 KOG98186.1 - 0.032 13.6 0.0 0.054 12.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.6 KOG98186.1 - 0.036 13.6 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 KOG98186.1 - 0.038 14.0 0.0 0.076 13.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.16 KOG98186.1 - 0.042 13.0 0.0 0.1 11.7 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 KOG98186.1 - 0.046 12.4 0.0 0.083 11.5 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus RNA_pol_Rbc25 PF08292.7 KOG98187.1 - 7.4e-46 155.3 0.1 1e-45 154.8 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.12 KOG98187.1 - 1.5e-20 73.1 0.0 2.1e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 LTV PF04180.9 KOG98188.1 - 1.1e-161 539.0 35.3 1.3e-161 538.8 24.5 1.0 1 0 0 1 1 1 1 Low temperature viability protein DUF4559 PF15112.1 KOG98188.1 - 1.5 7.8 7.4 0.056 12.5 1.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) DUF3294 PF07957.6 KOG98189.1 - 1.1e-85 286.5 7.2 1.2e-85 286.4 5.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) Viral_env_E26 PF11050.3 KOG98189.1 - 0.094 11.8 0.4 0.16 11.1 0.2 1.3 1 1 0 1 1 1 0 Virus envelope protein E26 Tricorn_C1 PF14684.1 KOG98189.1 - 0.14 12.0 0.1 3 7.7 0.0 2.6 2 0 0 2 2 2 0 Tricorn protease C1 domain Sdh_cyt PF01127.17 KOG98190.1 - 1.5e-19 69.9 4.0 2.1e-19 69.5 2.8 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Abhydrolase_1 PF00561.15 KOG98191.1 - 1.9e-31 109.4 0.1 2.7e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.11 KOG98191.1 - 1.1e-21 75.8 0.1 2e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_6 PF12697.2 KOG98191.1 - 4e-06 26.8 0.0 1.1e-05 25.4 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOG98191.1 - 4.1e-05 23.3 0.0 0.00043 20.0 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 KOG98191.1 - 0.00051 19.5 0.0 0.22 10.9 0.0 2.4 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.11 KOG98191.1 - 0.0045 16.4 0.0 1.5 8.2 0.0 2.3 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Ndr PF03096.9 KOG98191.1 - 0.084 11.3 0.1 0.27 9.6 0.0 1.8 2 0 0 2 2 2 0 Ndr family Pkinase PF00069.20 KOG98192.1 - 7.6e-73 244.8 0.1 1.1e-72 244.2 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98192.1 - 1.9e-33 115.6 0.0 2.7e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG98192.1 - 0.00025 20.0 0.0 0.00043 19.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG98192.1 - 0.041 12.9 0.1 0.15 11.1 0.1 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1871 PF08958.5 KOG98192.1 - 0.084 12.9 0.8 0.17 11.9 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1871) APH PF01636.18 KOG98192.1 - 0.086 12.5 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Patatin PF01734.17 KOG98192.1 - 1 9.2 3.1 2 8.2 2.2 1.4 1 0 0 1 1 1 0 Patatin-like phospholipase DASH_Hsk3 PF08227.6 KOG98193.1 - 5.3e-18 64.9 3.9 7.3e-18 64.4 2.7 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like DASH_Spc34 PF08657.5 KOG98193.1 - 0.0022 17.7 1.1 0.0023 17.6 0.8 1.0 1 0 0 1 1 1 1 DASH complex subunit Spc34 Occludin_ELL PF07303.8 KOG98193.1 - 0.022 15.4 0.6 0.027 15.2 0.4 1.1 1 0 0 1 1 1 0 Occludin homology domain DASH_Dad3 PF08656.5 KOG98193.1 - 0.029 14.0 2.6 0.038 13.6 1.8 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad3 COG5 PF10392.4 KOG98193.1 - 0.047 13.6 0.2 0.047 13.6 0.1 1.1 1 0 0 1 1 1 0 Golgi transport complex subunit 5 IFP_35_N PF07334.8 KOG98193.1 - 0.049 13.5 1.6 0.059 13.3 1.1 1.2 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus GvpK PF05121.7 KOG98193.1 - 0.054 13.3 0.6 0.059 13.1 0.4 1.1 1 0 0 1 1 1 0 Gas vesicle protein K Prominin PF05478.6 KOG98193.1 - 0.098 10.1 1.2 0.1 10.1 0.8 1.0 1 0 0 1 1 1 0 Prominin DUF342 PF03961.8 KOG98193.1 - 0.12 10.8 0.6 0.12 10.7 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) bZIP_Maf PF03131.12 KOG98193.1 - 0.19 12.0 2.4 0.22 11.8 1.7 1.1 1 0 0 1 1 1 0 bZIP Maf transcription factor Spc24 PF08286.6 KOG98193.1 - 0.29 10.8 2.3 0.34 10.6 1.6 1.1 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 L31 PF09784.4 KOG98194.1 - 3.4e-45 152.3 3.2 4.2e-45 152.0 2.2 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Cmc1 PF08583.5 KOG98195.1 - 7.3e-20 70.5 4.7 9.7e-20 70.1 3.2 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Pterin_4a PF01329.14 KOG98195.1 - 0.0075 16.0 0.1 0.0076 15.9 0.0 1.3 1 1 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Acetyltransf_CG PF14542.1 KOG98195.1 - 0.011 15.5 0.2 0.019 14.8 0.1 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF4434 PF14488.1 KOG98195.1 - 0.015 15.0 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) CHCH PF06747.8 KOG98195.1 - 0.26 11.2 5.6 0.79 9.7 0.3 2.2 1 1 1 2 2 2 0 CHCH domain COX17 PF05051.8 KOG98195.1 - 1.2 9.1 4.0 1.6 8.7 0.2 2.5 2 1 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Adaptin_N PF01602.15 KOG98196.1 - 2.5e-138 461.6 22.4 3e-138 461.4 15.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 KOG98196.1 - 8.4e-21 74.6 5.1 8.4e-21 74.6 3.5 3.0 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 KOG98196.1 - 3.2e-11 43.3 4.7 1.4e-06 28.5 0.2 5.0 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.17 KOG98196.1 - 5.6e-06 25.9 7.3 0.13 12.4 0.0 5.6 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.1 KOG98196.1 - 0.012 16.0 1.5 57 4.3 0.0 4.4 3 1 1 4 4 4 0 HEAT-like repeat Bravo_FIGEY PF13882.1 KOG98196.1 - 0.13 13.2 2.0 0.27 12.1 1.4 1.5 1 0 0 1 1 1 0 Bravo-like intracellular region Arm PF00514.18 KOG98196.1 - 1.2 9.0 5.6 1.2 9.0 0.3 3.7 4 1 1 5 5 5 0 Armadillo/beta-catenin-like repeat Peptidase_M3 PF01432.15 KOG98197.1 - 1.9e-152 508.5 0.0 2.4e-152 508.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.1 KOG98197.1 - 0.3 10.4 0.1 0.48 9.7 0.1 1.2 1 0 0 1 1 1 0 Peptidase M50B-like TPR_2 PF07719.12 KOG98198.1 - 0.0002 20.9 1.6 0.36 10.8 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOG98198.1 - 0.0011 18.7 1.9 1.8 8.5 0.0 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOG98198.1 - 0.0058 16.1 2.4 1.2 8.9 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOG98198.1 - 0.055 13.2 4.2 2 8.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Luciferase_3H PF10284.4 KOG98198.1 - 0.066 13.1 0.1 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Luciferase helical bundle domain She2p PF11435.3 KOG98200.1 - 1.1e-94 315.5 5.4 1.3e-94 315.2 3.8 1.0 1 0 0 1 1 1 1 RNA binding protein She2p Myosin_head PF00063.16 KOG98201.1 - 5.4e-222 738.6 4.8 9.7e-222 737.8 3.3 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 KOG98201.1 - 1.1e-48 165.1 0.5 1e-47 162.0 0.0 2.4 2 0 0 2 2 2 1 Myosin tail SH3_1 PF00018.23 KOG98201.1 - 2.3e-11 42.8 0.0 4.4e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOG98201.1 - 3.8e-08 32.7 0.0 8.1e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOG98201.1 - 0.0012 18.3 0.0 0.0027 17.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain AAA_22 PF13401.1 KOG98201.1 - 0.0044 17.1 0.0 0.014 15.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOG98201.1 - 0.014 15.1 0.0 0.15 11.8 0.0 2.7 2 0 0 2 2 2 0 Part of AAA domain AAA_17 PF13207.1 KOG98201.1 - 0.048 14.4 0.0 0.28 11.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 KOG98201.1 - 0.049 13.6 0.0 0.31 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain NACHT PF05729.7 KOG98201.1 - 0.074 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Hpr_kinase_C PF07475.7 KOG98201.1 - 0.13 11.6 0.1 5 6.4 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain IQ PF00612.22 KOG98201.1 - 1.1 9.1 14.4 2 8.3 4.3 2.7 1 1 1 2 2 2 0 IQ calmodulin-binding motif His_Phos_1 PF00300.17 KOG98202.1 - 4.1e-16 59.4 0.0 6.1e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PGM_PMM_I PF02878.11 KOG98203.1 - 1.9e-34 118.1 0.2 3.4e-34 117.2 0.0 1.5 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 KOG98203.1 - 1.7e-24 86.0 0.0 3.3e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 KOG98203.1 - 7.8e-11 42.2 0.0 2.1e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 KOG98203.1 - 7.6e-10 38.6 0.0 1.6e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Pkinase PF00069.20 KOG98204.1 - 4.3e-68 229.2 0.0 7.4e-68 228.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98204.1 - 1.1e-30 106.5 0.0 1.8e-30 105.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 KOG98204.1 - 1.8e-10 41.1 0.2 1.8e-10 41.1 0.1 2.1 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 KOG98204.1 - 0.0025 16.8 0.0 0.0062 15.5 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOG98204.1 - 0.084 11.9 0.1 0.16 10.9 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG98204.1 - 0.14 11.8 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RRN3 PF05327.6 KOG98205.1 - 4.8e-189 629.1 10.7 5.8e-189 628.8 7.4 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 BUD22 PF09073.5 KOG98205.1 - 0.13 11.2 4.6 0.23 10.4 3.2 1.3 1 0 0 1 1 1 0 BUD22 SepZ PF06066.6 KOG98205.1 - 0.22 11.5 0.0 0.41 10.6 0.0 1.4 1 0 0 1 1 1 0 SepZ SPRY PF00622.23 KOG98206.1 - 5.2e-13 49.1 0.0 1.1e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 SPRY domain SRP9-21 PF05486.7 KOG98207.1 - 7e-23 80.1 0.3 7e-23 80.1 0.2 1.8 2 0 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) DUF3525 PF12039.3 KOG98207.1 - 0.13 10.7 0.0 0.15 10.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) WD40 PF00400.27 KOG98208.1 - 9.9e-19 66.4 17.9 0.00014 21.6 0.0 6.4 6 1 0 6 6 6 4 WD domain, G-beta repeat Mito_carr PF00153.22 KOG98209.1 - 4.3e-59 196.2 8.3 2.5e-19 68.7 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.11 KOG98209.1 - 0.061 13.2 0.0 3.5 7.6 0.0 2.6 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Vma12 PF11712.3 KOG98210.1 - 5.9e-37 126.5 1.7 8.1e-37 126.0 1.2 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase Na_H_Exchanger PF00999.16 KOG98210.1 - 0.018 13.5 0.2 0.023 13.2 0.1 1.1 1 0 0 1 1 1 0 Sodium/hydrogen exchanger family MscS_TM PF12794.2 KOG98210.1 - 0.031 12.9 0.4 0.031 12.9 0.3 1.5 1 1 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF3169 PF11368.3 KOG98210.1 - 0.047 12.8 1.6 0.068 12.3 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) 2TM PF13239.1 KOG98210.1 - 0.049 13.6 0.7 0.049 13.6 0.5 1.8 2 0 0 2 2 2 0 2TM domain CS PF04969.11 KOG98211.1 - 0.0072 16.8 0.2 0.014 15.9 0.1 1.5 1 1 0 1 1 1 1 CS domain Med15 PF09606.5 KOG98211.1 - 0.7 8.0 9.3 0.82 7.7 6.4 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Pkinase PF00069.20 KOG98212.1 - 1.8e-63 214.1 0.0 2.4e-63 213.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98212.1 - 1.7e-27 96.1 0.0 6.8e-26 90.8 0.0 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOG98212.1 - 0.095 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AP_endonuc_2 PF01261.19 KOG98213.1 - 5e-30 104.3 0.0 6.8e-30 103.9 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel XPG_N PF00752.12 KOG98214.1 - 1.2e-39 134.5 0.0 2.6e-39 133.5 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 KOG98214.1 - 7.3e-28 96.4 0.0 1.9e-27 95.1 0.0 1.7 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.15 KOG98214.1 - 1.3e-05 25.2 2.5 3.4e-05 23.9 0.0 2.6 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold 5_3_exonuc_N PF02739.11 KOG98214.1 - 0.013 14.8 0.0 0.027 13.8 0.0 1.5 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain HHH_2 PF12826.2 KOG98214.1 - 0.029 14.2 0.1 0.12 12.2 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif CDKN3 PF05706.7 KOG98214.1 - 0.035 13.5 0.0 0.054 12.9 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) BAF1_ABF1 PF04684.8 KOG98215.1 - 5.5e-91 305.8 22.2 7.7e-53 180.0 5.5 6.6 3 2 3 6 6 6 4 BAF1 / ABF1 chromatin reorganising factor DBD_Tnp_Mut PF03108.10 KOG98215.1 - 0.0002 20.8 0.0 0.0004 19.8 0.0 1.5 1 0 0 1 1 1 1 MuDR family transposase KTI12 PF08433.5 KOG98216.1 - 2.8e-98 328.4 0.1 3.2e-98 328.2 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.1 KOG98216.1 - 1.7e-07 31.6 0.0 4.6e-07 30.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOG98216.1 - 1.4e-06 28.2 0.0 3.1e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOG98216.1 - 1.6e-06 28.9 0.0 2.8e-06 28.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.15 KOG98216.1 - 0.00048 19.8 0.0 0.00086 18.9 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_22 PF13401.1 KOG98216.1 - 0.0024 18.0 0.0 0.0073 16.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 KOG98216.1 - 0.003 17.7 0.0 0.0078 16.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOG98216.1 - 0.0036 17.3 0.0 0.015 15.2 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.1 KOG98216.1 - 0.0078 16.1 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KOG98216.1 - 0.01 15.7 0.0 0.025 14.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain 6PF2K PF01591.13 KOG98216.1 - 0.01 14.9 1.4 0.11 11.5 0.1 2.5 2 1 0 2 2 2 0 6-phosphofructo-2-kinase NACHT PF05729.7 KOG98216.1 - 0.017 14.7 0.0 0.032 13.9 0.0 1.6 1 1 0 1 1 1 0 NACHT domain MobB PF03205.9 KOG98216.1 - 0.034 13.8 0.0 0.066 12.9 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SRPRB PF09439.5 KOG98216.1 - 0.035 13.3 0.1 0.065 12.4 0.1 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit UPF0079 PF02367.12 KOG98216.1 - 0.044 13.4 0.0 0.16 11.5 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 NTPase_1 PF03266.10 KOG98216.1 - 0.053 13.2 1.1 0.21 11.2 0.0 2.2 3 0 0 3 3 2 0 NTPase Elong_Iki1 PF10483.4 KOG98216.1 - 0.055 12.8 0.6 0.12 11.7 0.1 1.7 2 0 0 2 2 2 0 Elongator subunit Iki1 cobW PF02492.14 KOG98216.1 - 0.078 12.4 0.1 0.24 10.8 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Mg_chelatase PF01078.16 KOG98216.1 - 0.12 11.4 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Hap4_Hap_bind PF10297.4 KOG98217.1 - 6.2e-08 32.2 6.4 1.6e-07 30.8 4.4 1.8 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 Drc1-Sld2 PF11719.3 KOG98218.1 - 2e-69 234.7 25.9 3.1e-67 227.5 18.0 2.0 1 1 0 1 1 1 1 DNA replication and checkpoint protein NAD_binding_10 PF13460.1 KOG98219.1 - 3.7e-06 27.0 0.3 9.1e-06 25.7 0.1 1.7 2 0 0 2 2 2 1 NADH(P)-binding adh_short PF00106.20 KOG98219.1 - 1.3e-05 25.1 0.0 2.3e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.16 KOG98219.1 - 0.00018 20.9 0.0 0.00027 20.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 KOG98219.1 - 0.0019 18.5 0.1 0.0095 16.3 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 KOG98219.1 - 0.0036 16.4 0.0 0.0054 15.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain KR PF08659.5 KOG98219.1 - 0.01 15.4 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 0 KR domain Saccharop_dh PF03435.13 KOG98219.1 - 0.021 13.8 0.2 0.043 12.8 0.1 1.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase NAD_binding_7 PF13241.1 KOG98219.1 - 0.031 14.5 0.1 0.083 13.1 0.1 1.6 1 1 0 1 1 1 0 Putative NAD(P)-binding NmrA PF05368.8 KOG98219.1 - 0.034 13.4 0.2 0.068 12.4 0.1 1.6 2 0 0 2 2 2 0 NmrA-like family THF_DHG_CYH_C PF02882.14 KOG98219.1 - 0.039 13.0 0.0 0.07 12.1 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.13 KOG98219.1 - 0.063 12.9 0.1 0.091 12.3 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 KOG98219.1 - 0.087 12.9 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase RmlD_sub_bind PF04321.12 KOG98219.1 - 0.14 11.0 0.0 0.24 10.2 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain Aminotran_1_2 PF00155.16 KOG98220.1 - 8.2e-99 330.9 0.0 9.3e-99 330.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II SIS PF01380.17 KOG98222.1 - 3.4e-61 204.6 0.0 6e-30 103.5 0.0 2.2 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 KOG98222.1 - 1e-28 100.0 0.0 1.5e-20 73.2 0.0 2.2 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 KOG98222.1 - 2.2e-18 66.4 0.0 4.9e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 KOG98222.1 - 5.4e-11 42.3 0.0 1.1e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 KOG98222.1 - 4.1e-09 35.5 0.1 7.4e-09 34.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Peptidase_M18 PF02127.10 KOG98223.1 - 1.3e-154 514.8 0.0 2.8e-154 513.7 0.0 1.5 2 0 0 2 2 2 1 Aminopeptidase I zinc metalloprotease (M18) Pkinase PF00069.20 KOG98224.1 - 1.5e-70 237.3 0.1 1.1e-69 234.4 0.1 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98224.1 - 1.3e-34 119.4 0.1 3.8e-33 114.6 0.1 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOG98224.1 - 0.0016 18.2 0.0 0.012 15.4 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 KOG98224.1 - 0.0048 15.9 0.0 0.0091 15.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_A22B PF04258.8 KOG98225.1 - 1.9e-83 280.3 13.5 3.1e-83 279.6 9.3 1.3 1 0 0 1 1 1 1 Signal peptide peptidase DUF3815 PF12821.2 KOG98225.1 - 0.011 15.7 0.2 0.011 15.7 0.2 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3815) LrgA PF03788.9 KOG98225.1 - 0.058 13.0 0.1 0.058 13.0 0.1 2.9 4 0 0 4 4 4 0 LrgA family Utp11 PF03998.8 KOG98226.1 - 4.1e-71 239.6 36.0 4.7e-71 239.4 24.9 1.0 1 0 0 1 1 1 1 Utp11 protein Phospholip_B PF04916.8 KOG98226.1 - 0.0032 15.6 1.1 0.0032 15.6 0.8 1.4 1 1 0 1 1 1 1 Phospholipase B DUF2529 PF10740.4 KOG98226.1 - 0.023 14.1 2.4 0.045 13.1 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2529) Lipoprotein_10 PF03202.8 KOG98226.1 - 9.7 6.2 15.7 0.41 10.6 5.7 2.1 1 1 1 2 2 2 0 Putative mycoplasma lipoprotein, C-terminal region PIR PF00399.14 KOG98229.1 - 5.9e-08 31.7 4.6 1.9e-07 30.1 3.2 2.0 1 0 0 1 1 1 1 Yeast PIR protein repeat Pol_alpha_B_N PF08418.5 KOG98229.1 - 0.061 12.8 15.1 0.08 12.4 10.4 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DUF4614 PF15391.1 KOG98229.1 - 0.27 10.9 13.4 0.56 9.9 9.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Macoilin PF09726.4 KOG98229.1 - 5.5 5.1 16.6 6.2 4.9 11.5 1.1 1 0 0 1 1 1 0 Transmembrane protein Golgin_A5 PF09787.4 KOG98229.1 - 9.9 4.5 15.7 13 4.1 10.9 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF572 PF04502.8 KOG98230.1 - 1.2e-51 175.8 13.8 1.6e-51 175.4 9.6 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Cytochrom_C552 PF02335.10 KOG98230.1 - 0.69 8.5 8.2 0.19 10.3 0.1 2.1 2 0 0 2 2 2 0 Cytochrome c552 Mut7-C PF01927.11 KOG98230.1 - 0.82 9.6 3.9 0.27 11.1 0.1 1.9 2 1 0 2 2 2 0 Mut7-C RNAse domain GET2 PF08690.5 KOG98230.1 - 0.87 8.7 8.2 1.1 8.4 4.2 1.9 1 1 1 2 2 2 0 GET complex subunit GET2 E7 PF00527.13 KOG98230.1 - 1.3 9.2 0.0 1.3 9.2 0.0 2.7 2 1 0 2 2 2 0 E7 protein, Early protein RRN3 PF05327.6 KOG98230.1 - 1.3 7.0 9.9 1.9 6.5 6.9 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 V_ATPase_I PF01496.14 KOG98230.1 - 9.6 3.9 8.3 15 3.3 5.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Abhydrolase_1 PF00561.15 KOG98231.1 - 2e-24 86.4 0.0 3e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOG98231.1 - 4.9e-19 69.1 0.0 6.4e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOG98231.1 - 1.2e-17 64.0 0.0 2.3e-17 63.1 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 KOG98231.1 - 1.3e-10 41.0 0.2 2.8e-10 39.8 0.0 1.7 2 0 0 2 2 2 1 Putative lysophospholipase Peptidase_S9 PF00326.16 KOG98231.1 - 3.5e-05 23.1 0.5 0.00041 19.6 0.1 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.13 KOG98231.1 - 5.3e-05 22.5 0.1 0.0025 17.1 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family FSH1 PF03959.8 KOG98231.1 - 0.024 14.0 0.1 0.12 11.8 0.0 1.9 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Chlorophyllase2 PF12740.2 KOG98231.1 - 0.034 13.0 0.0 0.054 12.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Chlorophyllase PF07224.6 KOG98231.1 - 0.035 12.8 0.0 0.046 12.5 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Abhydrolase_3 PF07859.8 KOG98231.1 - 0.12 11.9 0.0 0.41 10.1 0.0 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold RasGAP PF00616.14 KOG98233.1 - 2.3e-45 154.7 4.0 2.3e-45 154.7 2.8 2.1 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.25 KOG98233.1 - 0.00062 19.5 1.2 0.0012 18.6 0.2 1.9 2 0 0 2 2 2 1 C2 domain CRAL_TRIO PF00650.15 KOG98234.1 - 1.1e-34 119.1 0.3 2e-34 118.3 0.2 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 KOG98234.1 - 1.9e-13 50.3 0.9 5.8e-13 48.7 0.6 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 KOG98234.1 - 3e-05 23.9 0.4 6.9e-05 22.7 0.1 1.7 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain EF-hand_like PF09279.6 KOG98234.1 - 0.11 12.4 0.3 0.28 11.2 0.2 1.6 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like CUE PF02845.11 KOG98235.1 - 9.6e-20 69.7 3.1 1e-10 40.8 0.2 3.4 3 0 0 3 3 3 2 CUE domain Smr PF01713.16 KOG98235.1 - 6.4e-13 48.7 0.0 1.3e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Smr domain CENP-C_C PF11699.3 KOG98236.1 - 1.3e-30 105.1 1.7 3e-30 104.0 1.2 1.6 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.1 KOG98236.1 - 2.6e-23 83.1 6.5 2.6e-23 83.1 4.5 3.0 2 1 1 3 3 3 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.6 KOG98236.1 - 0.0065 15.9 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Cupin domain AT_hook PF02178.14 KOG98236.1 - 0.096 12.4 5.4 0.29 10.9 3.8 1.9 1 0 0 1 1 1 0 AT hook motif Flavoprotein PF02441.14 KOG98237.1 - 1.1e-38 131.8 0.2 1.1e-38 131.8 0.1 1.8 2 0 0 2 2 2 1 Flavoprotein Cyto_heme_lyase PF01265.12 KOG98238.1 - 3.5e-78 262.7 4.1 7.3e-78 261.7 2.8 1.5 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase ParBc PF02195.13 KOG98239.1 - 6.7e-24 83.8 0.0 7.9e-24 83.5 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain Ldh_1_C PF02866.13 KOG98240.1 - 4.1e-53 179.6 0.0 7.2e-53 178.8 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 KOG98240.1 - 3.3e-43 146.9 0.1 5.2e-43 146.2 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 KOG98240.1 - 0.0012 17.5 0.0 0.0018 17.0 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family zf-CHY PF05495.7 KOG98241.1 - 8.4e-16 57.8 13.5 1.2e-15 57.3 9.3 1.2 1 0 0 1 1 1 1 CHY zinc finger A2L_zn_ribbon PF08792.5 KOG98241.1 - 0.00016 20.9 0.3 0.00016 20.9 0.2 2.0 2 0 0 2 2 2 1 A2L zinc ribbon domain zf-RING_4 PF14570.1 KOG98241.1 - 0.00091 18.7 0.7 0.00091 18.7 0.5 3.0 2 1 1 3 3 3 1 RING/Ubox like zinc-binding domain TF_Zn_Ribbon PF08271.7 KOG98241.1 - 0.027 13.7 0.7 0.027 13.7 0.5 2.0 2 0 0 2 2 2 0 TFIIB zinc-binding DZR PF12773.2 KOG98241.1 - 0.044 13.6 8.4 0.52 10.1 5.8 2.3 1 1 0 1 1 1 0 Double zinc ribbon LIM PF00412.17 KOG98241.1 - 0.061 13.3 14.1 1.4 9.0 3.0 2.7 1 1 1 2 2 2 0 LIM domain DUF2296 PF10058.4 KOG98241.1 - 0.07 12.8 0.5 0.07 12.8 0.4 2.5 2 1 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) HypA PF01155.14 KOG98241.1 - 0.28 10.8 6.7 0.18 11.4 2.7 1.8 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family PhnA_Zn_Ribbon PF08274.7 KOG98241.1 - 0.33 10.7 0.1 0.33 10.7 0.1 3.4 3 1 1 4 4 4 0 PhnA Zinc-Ribbon C1_4 PF07975.7 KOG98241.1 - 0.61 10.1 10.4 11 6.0 5.5 2.5 1 1 0 1 1 1 0 TFIIH C1-like domain zf-RING_3 PF14369.1 KOG98241.1 - 0.85 9.6 9.8 0.16 12.0 1.0 2.7 2 1 1 3 3 3 0 zinc-finger Cytochrome_C7 PF14522.1 KOG98241.1 - 0.91 9.2 9.6 0.39 10.3 5.0 1.6 1 1 0 1 1 1 0 Cytochrome c7 DUF164 PF02591.10 KOG98241.1 - 1 9.2 5.0 7.7 6.4 0.5 2.4 1 1 1 2 2 2 0 Putative zinc ribbon domain DUF2318 PF10080.4 KOG98241.1 - 1.1 9.0 5.2 1.6 8.5 2.5 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) zf-C3HC4_3 PF13920.1 KOG98241.1 - 3.8 7.2 11.9 2.7 7.7 1.7 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_6 PF14599.1 KOG98241.1 - 3.9 7.3 8.9 0.16 11.8 1.4 2.1 1 1 1 2 2 2 0 Zinc-ribbon Zn_ribbon_recom PF13408.1 KOG98241.1 - 8.5 6.7 8.9 0.44 10.8 1.6 2.3 2 2 0 2 2 2 0 Recombinase zinc beta ribbon domain Zn_Tnp_IS1595 PF12760.2 KOG98241.1 - 8.6 6.2 10.0 11 5.9 1.4 2.7 1 1 1 2 2 2 0 Transposase zinc-ribbon domain SURF6 PF04935.7 KOG98242.1 - 5e-55 186.0 56.0 5e-55 186.0 38.8 3.1 2 1 1 3 3 3 1 Surfeit locus protein 6 RRP14 PF15459.1 KOG98242.1 - 1.1e-18 66.9 2.6 1.1e-18 66.9 1.8 8.2 5 3 1 6 6 6 1 60S ribosome biogenesis protein Rrp14 V-ATPase_C PF03223.10 KOG98243.1 - 1.6e-122 409.0 0.5 1.8e-122 408.8 0.3 1.0 1 0 0 1 1 1 1 V-ATPase subunit C NUC130_3NT PF08158.7 KOG98243.1 - 0.012 15.8 0.2 6.8 7.0 0.0 2.6 2 0 0 2 2 2 0 NUC130/3NT domain Kinesin PF00225.18 KOG98244.1 - 1.1e-70 237.9 3.9 1.1e-70 237.9 2.7 1.6 2 0 0 2 2 2 1 Kinesin motor domain DUF3811 PF11656.3 KOG98244.1 - 9.4 6.3 10.0 0.36 10.9 2.1 2.3 2 0 0 2 2 2 0 YjbD family (DUF3811) OB_NTP_bind PF07717.11 KOG98245.1 - 1.5e-19 69.8 0.0 3.1e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 KOG98245.1 - 3.9e-19 68.5 0.0 8.3e-19 67.5 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 KOG98245.1 - 3.4e-10 39.6 0.0 8.8e-10 38.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOG98245.1 - 7.8e-10 38.5 0.1 1.4e-09 37.6 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KOG98245.1 - 6.8e-06 26.2 0.1 1.3e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOG98245.1 - 0.00022 20.9 0.0 0.0006 19.5 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain ABC_tran PF00005.22 KOG98245.1 - 0.0023 18.2 0.1 0.084 13.1 0.0 2.8 2 1 1 3 3 3 1 ABC transporter AAA_29 PF13555.1 KOG98245.1 - 0.0033 16.9 0.3 0.009 15.5 0.0 1.9 2 0 0 2 2 1 1 P-loop containing region of AAA domain AAA_14 PF13173.1 KOG98245.1 - 0.006 16.4 0.1 0.056 13.3 0.1 2.3 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 KOG98245.1 - 0.021 14.6 0.0 0.36 10.6 0.0 2.2 1 1 0 2 2 2 0 Type III restriction enzyme, res subunit Helicase_RecD PF05127.9 KOG98245.1 - 0.035 13.7 0.0 0.063 12.9 0.0 1.4 1 0 0 1 1 1 0 Helicase SRP54 PF00448.17 KOG98245.1 - 0.036 13.5 0.1 0.15 11.5 0.1 2.0 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.9 KOG98245.1 - 0.054 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_10 PF12846.2 KOG98245.1 - 0.055 12.8 0.0 2.1 7.6 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain AAA_23 PF13476.1 KOG98245.1 - 0.064 13.5 1.2 0.14 12.4 0.3 2.0 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.1 KOG98245.1 - 0.078 12.5 0.4 0.73 9.3 0.0 2.4 1 1 1 2 2 2 0 AAA domain DUF4448 PF14610.1 KOG98246.1 - 3.8e-59 199.3 0.4 7e-59 198.5 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Toprim_C_rpt PF13368.1 KOG98247.1 - 3.9 8.0 5.3 8.1 7.0 0.7 2.5 2 0 0 2 2 2 0 Topoisomerase C-terminal repeat RRM_5 PF13893.1 KOG98248.1 - 3.8e-05 23.4 0.2 0.00026 20.7 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG98248.1 - 0.00071 19.5 0.0 0.0069 16.3 0.0 2.4 2 1 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOG98248.1 - 0.0014 18.1 0.0 0.0055 16.3 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HSP70 PF00012.15 KOG98249.1 - 6.9e-50 169.5 0.1 6.9e-50 169.5 0.1 2.1 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 KOG98249.1 - 2.1e-05 23.2 0.0 0.00027 19.6 0.0 2.1 1 1 0 1 1 1 1 MreB/Mbl protein CTD_bind PF04818.8 KOG98249.1 - 0.014 15.6 0.2 0.11 12.7 0.0 2.7 3 0 0 3 3 3 0 RNA polymerase II-binding domain. MCP_N PF05581.7 KOG98249.1 - 0.062 13.4 3.2 0.14 12.2 0.0 3.0 4 0 0 4 4 4 0 Vibrio chemotaxis protein N terminus GAF_2 PF13185.1 KOG98251.1 - 1.5e-07 32.0 0.0 7.8e-07 29.6 0.0 1.9 1 1 0 1 1 1 1 GAF domain GAF PF01590.21 KOG98251.1 - 0.028 14.5 0.0 0.037 14.1 0.0 1.3 1 1 0 1 1 1 0 GAF domain Nucleoporin_FG PF13634.1 KOG98253.1 - 1.6e-44 150.7 287.1 1.4e-13 51.0 27.6 9.0 1 1 8 10 10 10 9 Nucleoporin FG repeat region Nucleoporin2 PF04096.9 KOG98253.1 - 3.9e-43 146.6 0.0 7.3e-43 145.7 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin autopeptidase NDK PF00334.14 KOG98254.1 - 1.5e-55 186.6 0.0 1.7e-55 186.5 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Bap31 PF05529.7 KOG98256.1 - 1.1e-54 184.7 4.6 1.3e-54 184.5 3.2 1.0 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like Sec2p PF06428.6 KOG98256.1 - 0.0056 16.5 5.5 0.0067 16.2 3.4 1.4 1 1 0 1 1 1 1 GDP/GTP exchange factor Sec2p TACC PF05010.9 KOG98256.1 - 0.014 15.1 4.3 0.02 14.6 3.0 1.2 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) Rpp20 PF12328.3 KOG98256.1 - 0.029 14.0 3.0 0.045 13.4 2.1 1.2 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P DUF2968 PF11180.3 KOG98256.1 - 0.11 11.8 2.5 0.16 11.3 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) CorA PF01544.13 KOG98257.1 - 4.1e-39 134.3 5.5 7.4e-21 74.4 0.3 3.3 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein Ycf1 PF05758.7 KOG98258.1 - 0.022 12.5 10.3 0.024 12.4 7.1 1.0 1 0 0 1 1 1 0 Ycf1 DDHD PF02862.12 KOG98258.1 - 0.022 14.5 5.5 0.026 14.3 3.8 1.2 1 0 0 1 1 1 0 DDHD domain Hid1 PF12722.2 KOG98258.1 - 0.23 9.0 10.2 0.28 8.8 7.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FHIPEP PF00771.15 KOG98258.1 - 0.4 8.9 4.3 0.43 8.8 3.0 1.1 1 0 0 1 1 1 0 FHIPEP family Neur_chan_memb PF02932.11 KOG98258.1 - 1.1 9.0 6.4 1.2 9.0 4.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PPP4R2 PF09184.6 KOG98258.1 - 1.6 8.2 19.0 2 7.8 13.2 1.1 1 0 0 1 1 1 0 PPP4R2 DUF2201_N PF13203.1 KOG98258.1 - 1.9 7.5 12.7 2.5 7.2 8.8 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain Presenilin PF01080.12 KOG98258.1 - 2.2 7.0 6.1 2.8 6.6 4.3 1.2 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.5 KOG98258.1 - 2.4 6.4 9.4 2.8 6.2 6.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup YaaC PF14175.1 KOG98258.1 - 2.6 6.9 9.5 3.7 6.4 6.6 1.2 1 0 0 1 1 1 0 YaaC-like Protein GAGA_bind PF06217.7 KOG98258.1 - 4.4 7.1 16.6 5.6 6.8 11.5 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family zf-C2H2 PF00096.21 KOG98259.1 - 9.3e-11 41.4 12.6 6.3e-06 26.2 2.0 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG98259.1 - 1.6e-08 34.2 11.8 0.00026 21.1 1.7 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KOG98259.1 - 8.2e-08 32.1 18.0 3.3e-06 27.1 1.5 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-BED PF02892.10 KOG98259.1 - 8e-05 22.3 6.1 0.029 14.1 0.4 2.6 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_jaz PF12171.3 KOG98259.1 - 0.00018 21.5 11.4 0.078 13.1 2.6 3.0 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KOG98259.1 - 0.0033 17.5 6.6 1.3 9.3 1.4 3.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 KOG98259.1 - 0.073 13.1 8.0 0.86 9.7 1.4 3.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.6 KOG98259.1 - 0.076 12.6 2.3 7.8 6.1 0.1 3.0 2 1 1 3 3 3 0 GAGA factor zf-C2H2_6 PF13912.1 KOG98259.1 - 0.093 12.6 7.2 0.55 10.2 1.0 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.7 KOG98259.1 - 0.25 11.4 4.1 0.61 10.2 2.8 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-LYAR PF08790.6 KOG98259.1 - 0.56 9.9 3.6 12 5.6 0.1 2.7 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger DHquinase_I PF01487.10 KOG98260.1 - 0.028 14.0 0.4 0.04 13.5 0.3 1.2 1 0 0 1 1 1 0 Type I 3-dehydroquinase Streptin-Immun PF11083.3 KOG98260.1 - 0.037 14.0 6.2 0.047 13.6 3.6 1.7 1 1 1 2 2 2 0 Lantibiotic streptin immunity protein ComJ PF11033.3 KOG98260.1 - 0.087 12.4 0.2 0.1 12.1 0.1 1.1 1 0 0 1 1 1 0 Competence protein J (ComJ) LAGLIDADG_2 PF03161.8 KOG98260.1 - 0.12 12.2 0.4 4.5 7.1 0.0 2.1 2 0 0 2 2 2 0 LAGLIDADG DNA endonuclease family DUF3195 PF11424.3 KOG98260.1 - 0.3 11.3 2.2 1.2 9.3 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3195) IncA PF04156.9 KOG98260.1 - 1.1 8.8 3.8 1.7 8.2 1.4 1.8 1 1 0 1 1 1 0 IncA protein F_bP_aldolase PF01116.15 KOG98261.1 - 3.5e-92 308.5 0.0 3.9e-92 308.4 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II DWNN PF08783.6 KOG98262.1 - 1.4e-32 111.3 2.0 2.4e-32 110.7 0.1 2.1 2 0 0 2 2 2 1 DWNN domain zf-Nse PF11789.3 KOG98262.1 - 5.1e-05 22.7 0.3 0.00012 21.5 0.2 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-CCHC PF00098.18 KOG98262.1 - 0.0028 17.5 3.8 0.0028 17.5 2.6 2.1 2 0 0 2 2 2 1 Zinc knuckle Rubredoxin PF00301.15 KOG98262.1 - 0.0038 17.0 4.3 0.41 10.5 0.0 3.1 3 0 0 3 3 3 2 Rubredoxin zf-CCHC_2 PF13696.1 KOG98262.1 - 0.0038 16.6 4.9 0.0062 16.0 2.7 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.1 KOG98262.1 - 0.032 13.9 0.1 0.065 12.9 0.1 1.5 1 0 0 1 1 1 0 Zinc knuckle U-box PF04564.10 KOG98262.1 - 0.038 13.9 0.1 0.097 12.6 0.0 1.8 2 0 0 2 2 2 0 U-box domain zf-CCHC_5 PF14787.1 KOG98262.1 - 0.061 12.8 0.6 0.15 11.5 0.4 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-DNL PF05180.7 KOG98262.1 - 0.17 11.6 1.2 0.28 10.9 0.1 1.9 2 0 0 2 2 2 0 DNL zinc finger TF_Zn_Ribbon PF08271.7 KOG98262.1 - 0.59 9.4 4.8 0.73 9.1 0.2 2.6 2 0 0 2 2 2 0 TFIIB zinc-binding TFIIA_gamma_C PF02751.9 KOG98263.1 - 2.3e-27 94.5 0.9 3.5e-27 93.9 0.6 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.11 KOG98263.1 - 2.4e-25 87.8 0.2 3.2e-25 87.4 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TCTP PF00838.12 KOG98265.1 - 7.8e-73 243.8 3.0 8.8e-73 243.7 2.1 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein gp32 PF08804.5 KOG98265.1 - 0.11 12.6 0.1 0.54 10.4 0.0 2.0 2 0 0 2 2 2 0 gp32 DNA binding protein like adh_short PF00106.20 KOG98266.1 - 1.2e-15 57.8 0.0 9.5e-09 35.3 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.1 KOG98266.1 - 1.3e-12 48.0 0.1 3e-12 46.8 0.1 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOG98266.1 - 0.012 15.3 0.0 0.36 10.4 0.0 2.6 2 1 0 2 2 2 0 KR domain Epimerase PF01370.16 KOG98266.1 - 0.021 14.2 0.6 2 7.7 0.0 2.4 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family DUF1776 PF08643.5 KOG98266.1 - 0.054 12.6 0.3 0.075 12.1 0.2 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) CUE PF02845.11 KOG98267.1 - 1.1e-05 24.8 0.0 2.8e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 CUE domain UPF0203 PF05254.7 KOG98268.1 - 9.5e-31 105.4 2.1 1.1e-30 105.2 1.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) Cmc1 PF08583.5 KOG98268.1 - 0.00049 19.8 1.8 0.41 10.4 0.1 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.8 KOG98268.1 - 0.025 14.5 1.1 0.4 10.6 0.1 2.2 2 0 0 2 2 2 0 CHCH domain PaREP1 PF05942.6 KOG98268.1 - 0.026 14.4 0.1 0.029 14.2 0.0 1.1 1 0 0 1 1 1 0 Archaeal PaREP1/PaREP8 family COX6B PF02297.12 KOG98268.1 - 0.047 13.7 4.9 1.6 8.7 0.1 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb UCR_hinge PF02320.11 KOG98268.1 - 0.13 12.1 3.1 6 6.8 2.1 2.1 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein DASH_Ask1 PF08655.5 KOG98269.1 - 1.4e-29 101.7 0.2 3e-29 100.6 0.2 1.6 1 0 0 1 1 1 1 DASH complex subunit Ask1 CPSF73-100_C PF11718.3 KOG98269.1 - 0.19 11.0 3.5 0.39 10.0 2.5 1.5 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Frag1 PF10277.4 KOG98270.1 - 3e-85 285.0 23.4 3.7e-85 284.7 16.2 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Mem_trans PF03547.13 KOG98270.1 - 0.079 11.2 0.1 0.079 11.2 0.0 2.2 2 0 0 2 2 2 0 Membrane transport protein EVC2_like PF12297.3 KOG98270.1 - 0.14 10.7 0.4 0.2 10.2 0.3 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein DUF3812 PF12757.2 KOG98271.1 - 5.1e-26 91.1 0.7 5.1e-26 91.1 0.5 3.7 3 0 0 3 3 3 1 Protein of unknown function (DUF3812) Pkinase PF00069.20 KOG98272.1 - 2.9e-43 147.8 0.0 7.5e-43 146.5 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98272.1 - 6.3e-20 71.3 0.0 8.6e-17 61.0 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG98272.1 - 5.5e-05 22.2 0.0 0.00034 19.6 0.0 2.0 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 KOG98272.1 - 0.14 11.8 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2347 PF09804.4 KOG98273.1 - 5.8e-74 248.8 0.8 9.3e-74 248.2 0.5 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.1 KOG98273.1 - 3.9e-16 59.6 0.4 3.2e-08 33.8 0.1 3.0 2 1 1 3 3 3 2 Domain of unknown function (DUF4484) SPA PF08616.5 KOG98273.1 - 7.1e-08 32.1 0.1 1.6e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.4 KOG98273.1 - 9.6e-08 30.8 0.1 0.00055 18.5 0.0 2.8 2 1 0 2 2 2 2 Transport protein Avl9 Afi1 PF07792.7 KOG98273.1 - 0.061 13.3 0.3 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Glyco_hydro_76 PF03663.9 KOG98274.1 - 3e-154 513.8 26.2 3.8e-154 513.5 18.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 DNA_primase_lrg PF04104.9 KOG98275.1 - 1.3e-87 293.3 0.2 2.2e-87 292.6 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit KilA-N PF04383.8 KOG98276.1 - 1e-05 25.0 0.2 4e-05 23.2 0.1 2.0 1 1 0 1 1 1 1 KilA-N domain Spc42p PF11544.3 KOG98277.1 - 5.6e-24 83.8 13.9 5.6e-24 83.8 9.6 2.9 2 1 1 3 3 3 1 Spindle pole body component Spc42p DUF4116 PF13475.1 KOG98277.1 - 0.0061 16.0 0.7 0.018 14.4 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4116) Lsr2 PF11774.3 KOG98277.1 - 0.052 13.4 0.3 0.12 12.3 0.2 1.5 1 0 0 1 1 1 0 Lsr2 Atg14 PF10186.4 KOG98277.1 - 0.15 10.9 16.2 0.064 12.1 4.0 2.3 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Snf7 PF03357.16 KOG98278.1 - 3.3e-35 120.9 16.1 3.3e-35 120.9 11.2 1.5 2 0 0 2 2 2 1 Snf7 PAS_7 PF12860.2 KOG98278.1 - 0.014 15.3 5.3 0.43 10.6 0.1 3.3 2 1 2 4 4 4 0 PAS fold TAF8_C PF10406.4 KOG98278.1 - 0.33 11.0 2.0 0.84 9.7 0.1 2.5 2 0 0 2 2 2 0 Transcription factor TFIID complex subunit 8 C-term Eno-Rase_FAD_bd PF07055.7 KOG98278.1 - 0.33 10.9 3.8 0.28 11.1 0.8 2.3 2 1 0 2 2 2 0 Enoyl reductase FAD binding domain CheX PF13690.1 KOG98278.1 - 2.8 7.8 5.2 0.62 9.9 1.1 1.8 2 0 0 2 2 2 0 Chemotaxis phosphatase CheX Phasin PF05597.6 KOG98278.1 - 2.9 7.6 9.1 0.13 12.0 0.2 2.8 3 1 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) EF-1_beta_acid PF10587.4 KOG98278.1 - 7.1 6.8 7.0 41 4.4 1.3 3.1 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region Nfu_N PF08712.6 KOG98279.1 - 8.4e-25 86.2 0.0 2e-24 85.0 0.0 1.6 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.12 KOG98279.1 - 1.3e-24 85.6 0.0 2.2e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 NifU-like domain HOOK PF05622.7 KOG98279.1 - 0.01 13.6 0.3 0.015 13.1 0.2 1.2 1 0 0 1 1 1 0 HOOK protein YojJ PF10372.4 KOG98279.1 - 0.023 14.5 0.7 0.051 13.4 0.5 1.5 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus Lung_7-TM_R PF06814.8 KOG98280.1 - 2.5e-89 299.1 27.8 3.2e-89 298.7 19.3 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor Zn_clus PF00172.13 KOG98281.1 - 1.3e-09 37.7 12.7 2.3e-09 36.9 8.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UDPGP PF01704.13 KOG98282.1 - 6.6e-194 644.2 0.0 8.1e-194 643.9 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.1 KOG98282.1 - 0.0051 15.4 0.5 0.016 13.7 0.0 1.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4301) zf-RING_2 PF13639.1 KOG98283.1 - 7.5e-11 41.6 6.4 1.5e-10 40.7 4.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOG98283.1 - 5.2e-09 36.0 4.3 9.9e-09 35.1 3.0 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 KOG98283.1 - 1.5e-07 31.0 4.2 2.5e-07 30.2 2.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOG98283.1 - 4.5e-07 29.4 3.9 8.3e-07 28.5 2.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOG98283.1 - 2.4e-05 23.8 7.1 4.7e-05 22.9 4.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOG98283.1 - 3.1e-05 23.9 6.2 0.00014 21.7 4.3 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOG98283.1 - 0.001 18.8 2.2 0.002 17.9 1.5 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 KOG98283.1 - 0.0058 16.3 0.7 0.02 14.6 0.5 1.9 1 0 0 1 1 1 1 RING-type zinc-finger FANCL_C PF11793.3 KOG98283.1 - 0.044 13.7 5.1 0.14 12.1 3.5 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-P11 PF03854.9 KOG98283.1 - 2.8 7.4 6.6 0.93 9.0 2.3 1.8 2 0 0 2 2 2 0 P-11 zinc finger RINGv PF12906.2 KOG98283.1 - 6.2 6.9 7.6 0.8 9.8 2.2 1.7 2 0 0 2 2 2 0 RING-variant domain HAD_2 PF13419.1 KOG98284.1 - 1.5e-15 57.8 0.0 1.8e-15 57.5 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOG98284.1 - 9.5e-08 32.7 0.0 1.3e-07 32.2 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 KOG98284.1 - 0.0067 16.2 0.0 0.025 14.4 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD PF12710.2 KOG98284.1 - 0.045 13.9 0.0 0.057 13.5 0.0 1.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase HMG_box PF00505.14 KOG98286.1 - 6e-31 106.5 8.7 1.6e-17 63.5 1.5 4.1 4 0 0 4 4 4 2 HMG (high mobility group) box HMG_box_2 PF09011.5 KOG98286.1 - 1.9e-15 56.9 6.4 8.8e-11 42.0 1.5 4.1 4 0 0 4 4 4 2 HMG-box domain CHDNT PF08073.7 KOG98286.1 - 8.4e-06 25.3 0.0 0.012 15.3 0.0 2.5 2 0 0 2 2 2 2 CHDNT (NUC034) domain Macoilin PF09726.4 KOG98286.1 - 0.035 12.4 56.2 0.059 11.6 39.0 1.3 1 0 0 1 1 1 0 Transmembrane protein Malic_M PF03949.10 KOG98287.1 - 3.6e-78 262.6 0.1 5.3e-78 262.0 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 KOG98287.1 - 4e-63 212.2 0.1 1.4e-62 210.5 0.0 1.8 2 0 0 2 2 2 1 Malic enzyme, N-terminal domain Shikimate_DH PF01488.15 KOG98287.1 - 0.12 12.5 0.3 15 5.6 0.1 3.3 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase TFIIE_alpha PF02002.12 KOG98288.1 - 1.2e-35 121.1 0.0 1.2e-35 121.1 0.0 2.4 2 0 0 2 2 2 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.7 KOG98288.1 - 5.3e-09 35.2 0.7 5.3e-09 35.2 0.5 2.2 2 0 0 2 2 2 1 TFIIB zinc-binding Metal_resist PF13801.1 KOG98288.1 - 6.3 6.8 8.3 0.19 11.7 0.7 2.1 2 0 0 2 2 2 0 Heavy-metal resistance CENP-T PF15511.1 KOG98288.1 - 7.5 5.6 31.0 12 5.0 21.5 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T ThiF PF00899.16 KOG98289.1 - 7e-37 126.2 0.0 1.1e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 KOG98289.1 - 0.00011 22.2 0.0 0.00022 21.3 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 KOG98289.1 - 0.0077 16.2 0.2 0.031 14.2 0.0 2.0 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_7 PF13241.1 KOG98289.1 - 0.011 16.0 0.2 0.032 14.4 0.0 2.1 2 1 0 2 2 2 0 Putative NAD(P)-binding Saccharop_dh PF03435.13 KOG98289.1 - 0.011 14.7 0.5 0.049 12.6 0.3 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase ApbA PF02558.11 KOG98289.1 - 0.089 12.2 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sir1 PF11603.3 KOG98290.1 - 1.2e-10 41.6 7.5 7.2e-05 22.9 0.2 4.0 3 1 0 3 3 3 2 Regulatory protein Sir1 ADK PF00406.17 KOG98292.1 - 2.9e-50 170.0 0.0 3.8e-50 169.6 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_18 PF13238.1 KOG98292.1 - 1.2e-10 41.7 0.0 1.9e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 KOG98292.1 - 7.9e-08 31.8 0.2 0.0087 15.4 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase AAA_33 PF13671.1 KOG98292.1 - 2.1e-07 30.9 0.0 4.1e-07 29.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOG98292.1 - 8.2e-06 26.6 0.0 1.3e-05 25.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOG98292.1 - 0.0056 15.7 0.0 0.0085 15.2 0.0 1.4 1 1 0 1 1 1 1 Zeta toxin DUF4648 PF15505.1 KOG98293.1 - 0.015 15.5 0.1 0.016 15.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4648) Macoilin PF09726.4 KOG98294.1 - 0.008 14.5 29.9 0.01 14.1 20.7 1.0 1 0 0 1 1 1 1 Transmembrane protein TPR_1 PF00515.23 KOG98295.1 - 2.8e-37 124.8 23.4 1.4e-06 27.6 0.1 10.6 11 0 0 11 11 10 8 Tetratricopeptide repeat TPR_2 PF07719.12 KOG98295.1 - 6.2e-36 119.4 9.4 2e-05 24.1 0.0 10.4 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.1 KOG98295.1 - 2e-34 117.0 10.4 2.3e-08 33.5 0.1 6.8 6 1 0 6 6 6 5 TPR repeat Apc3 PF12895.2 KOG98295.1 - 7.2e-30 102.9 15.6 9.2e-22 76.9 0.1 5.8 4 2 2 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 KOG98295.1 - 9.7e-21 73.5 8.1 8.8e-08 31.9 0.0 7.0 5 3 2 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOG98295.1 - 3.4e-19 67.1 19.8 0.00041 19.9 0.0 9.0 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOG98295.1 - 1.4e-17 63.7 0.1 0.01 16.1 0.0 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOG98295.1 - 3.2e-16 59.5 0.0 0.073 13.7 0.0 6.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.1 KOG98295.1 - 1.3e-15 55.9 2.5 0.029 14.1 0.0 8.4 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOG98295.1 - 1.6e-15 55.9 7.0 0.095 12.9 0.0 8.8 9 1 0 9 9 8 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOG98295.1 - 1.1e-10 41.1 0.0 8 7.4 0.0 8.2 5 2 4 9 9 9 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOG98295.1 - 6.9e-08 32.1 0.0 7.9 6.5 0.0 7.6 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOG98295.1 - 5.4e-07 29.6 13.1 1.1 9.8 0.0 8.4 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_15 PF13429.1 KOG98295.1 - 1.4e-06 27.6 0.1 0.0048 16.0 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_21 PF09976.4 KOG98295.1 - 0.032 14.1 1.4 2.1 8.2 0.0 4.1 4 1 0 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOG98295.1 - 0.19 11.6 6.8 11 5.9 0.0 4.7 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Clathrin PF00637.15 KOG98295.1 - 0.73 9.4 14.5 0.052 13.1 1.2 4.2 4 0 0 4 4 4 0 Region in Clathrin and VPS TPR_3 PF07720.7 KOG98295.1 - 2.1 8.2 10.8 19 5.1 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat WD40 PF00400.27 KOG98296.1 - 1.3e-30 104.1 6.3 2.5e-07 30.3 0.6 5.4 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.3 KOG98296.1 - 6.9e-05 21.1 2.0 0.022 12.8 0.7 2.7 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 KOG98296.1 - 0.00022 20.1 4.6 1 8.0 0.0 3.8 2 1 2 4 4 4 3 Nup133 N terminal like BBS2_Mid PF14783.1 KOG98296.1 - 0.011 15.4 0.1 13 5.5 0.0 4.5 5 1 0 5 5 5 0 Ciliary BBSome complex subunit 2, middle region Ank PF00023.25 KOG98297.1 - 4.1e-18 64.1 0.1 1.3e-08 34.1 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOG98297.1 - 4.5e-14 52.5 3.3 1.4e-11 44.5 0.3 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOG98297.1 - 1.3e-13 51.0 0.1 3.6e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOG98297.1 - 9.7e-13 47.9 0.2 2.4e-08 33.9 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOG98297.1 - 2.5e-12 45.7 0.3 1.3e-05 25.0 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat TIG PF01833.19 KOG98297.1 - 2e-06 27.7 0.9 2e-06 27.7 0.6 3.0 3 0 0 3 3 3 1 IPT/TIG domain PPTA PF01239.17 KOG98298.1 - 6e-37 123.4 16.8 7.1e-08 31.4 0.2 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat DUF1748 PF08520.5 KOG98299.1 - 2.1e-18 65.7 0.2 3e-18 65.2 0.1 1.2 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) IFR3_antag PF14754.1 KOG98299.1 - 0.08 11.9 0.1 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 Papain-like auto-proteinase WD40 PF00400.27 KOG98300.1 - 1.3e-15 56.6 0.1 8e-05 22.3 0.0 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat AAA_12 PF13087.1 KOG98301.1 - 3.2e-58 196.4 0.0 3.2e-58 196.4 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.1 KOG98301.1 - 4.5e-56 190.0 4.7 8.3e-56 189.1 0.4 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOG98301.1 - 1.5e-12 47.1 0.0 1.1e-11 44.2 0.0 2.3 2 0 0 2 2 2 1 Part of AAA domain Viral_helicase1 PF01443.13 KOG98301.1 - 1.2e-10 41.2 1.8 0.0083 15.6 0.0 3.6 4 0 0 4 4 4 3 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.1 KOG98301.1 - 9.4e-08 31.8 0.0 0.00015 21.4 0.0 2.6 3 0 0 3 3 2 2 AAA domain ResIII PF04851.10 KOG98301.1 - 8.4e-06 25.7 1.0 2.3e-05 24.3 0.2 2.1 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 KOG98301.1 - 1.1e-05 25.0 0.4 0.00022 20.7 0.3 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase PhoH PF02562.11 KOG98301.1 - 1.4e-05 24.4 0.0 0.00015 21.1 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein DUF2075 PF09848.4 KOG98301.1 - 4.9e-05 22.4 2.2 0.0018 17.3 1.5 2.6 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 KOG98301.1 - 6.7e-05 23.0 0.0 0.00059 19.9 0.0 2.7 2 1 0 2 2 2 1 AAA domain UvrD-helicase PF00580.16 KOG98301.1 - 0.00046 19.5 8.1 0.00084 18.7 1.0 3.2 2 1 1 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_14 PF13173.1 KOG98301.1 - 0.0011 18.9 1.6 0.096 12.5 0.1 3.3 2 1 1 3 3 3 1 AAA domain Helicase_RecD PF05127.9 KOG98301.1 - 0.0036 16.9 0.0 0.027 14.1 0.0 2.6 2 1 0 2 2 2 1 Helicase UvrD_C_2 PF13538.1 KOG98301.1 - 0.0056 16.8 0.0 0.019 15.0 0.0 2.0 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_23 PF13476.1 KOG98301.1 - 0.0072 16.6 0.1 0.0072 16.6 0.1 3.6 3 1 1 4 4 4 1 AAA domain AAA PF00004.24 KOG98301.1 - 0.0087 16.2 0.0 0.029 14.5 0.0 2.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 KOG98301.1 - 0.01 15.2 0.0 0.025 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KOG98301.1 - 0.01 16.6 0.6 0.11 13.2 0.4 2.8 1 1 0 1 1 1 0 AAA domain Zot PF05707.7 KOG98301.1 - 0.018 14.5 0.1 0.14 11.6 0.0 2.5 3 0 0 3 3 3 0 Zonular occludens toxin (Zot) AAA_33 PF13671.1 KOG98301.1 - 0.021 14.7 0.2 0.19 11.5 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.1 KOG98301.1 - 0.022 14.7 0.0 0.046 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.9 KOG98301.1 - 0.055 13.1 0.0 0.18 11.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mt_ATP-synt_D PF05873.7 KOG98302.1 - 1.3e-15 57.3 4.0 1.6e-15 57.1 2.7 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) T5orf172 PF10544.4 KOG98302.1 - 0.042 14.2 0.2 0.076 13.4 0.1 1.5 1 1 0 1 1 1 0 T5orf172 domain CCDC74_C PF14917.1 KOG98302.1 - 0.048 13.7 1.6 0.4 10.7 0.2 2.2 1 1 1 2 2 2 0 Coiled coil protein 74, C terminal IncA PF04156.9 KOG98302.1 - 1.9 8.0 6.3 4.8 6.7 4.2 1.6 1 1 0 1 1 1 0 IncA protein Fungal_trans PF04082.13 KOG98303.1 - 6.2e-29 100.6 4.3 6.2e-29 100.6 3.0 2.2 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG98303.1 - 3.8e-10 39.4 7.2 6.8e-10 38.6 5.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SLEI_Leptospira PF07620.6 KOG98303.1 - 0.043 13.6 0.8 0.53 10.2 0.0 3.3 3 0 0 3 3 3 0 SLEI Npa1 PF11707.3 KOG98304.1 - 3.2e-102 341.9 5.7 3.2e-102 341.9 4.0 2.7 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal ARPC4 PF05856.7 KOG98305.1 - 6.5e-72 240.4 3.4 7.3e-72 240.2 2.3 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) FF PF01846.14 KOG98306.1 - 3.6e-40 135.6 39.2 2.1e-13 49.9 0.0 7.1 10 0 0 10 10 10 4 FF domain WW PF00397.21 KOG98306.1 - 3e-21 74.9 9.2 1.3e-11 44.0 0.6 3.2 2 0 0 2 2 2 2 WW domain Ydc2-catalyt PF09159.5 KOG98307.1 - 3.8e-55 187.3 2.1 5.5e-55 186.7 1.5 1.2 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pox_A22 PF04848.8 KOG98307.1 - 0.001 18.9 0.3 0.79 9.5 0.0 3.1 2 2 0 2 2 2 2 Poxvirus A22 protein HECT PF00632.20 KOG98308.1 - 6.7e-74 248.8 0.9 1.3e-73 247.9 0.6 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) EIAV_GP90 PF00971.13 KOG98308.1 - 0.032 12.6 0.2 2.3 6.5 0.1 2.2 2 0 0 2 2 2 0 EIAV coat protein, gp90 Ribosomal_L10 PF00466.15 KOG98309.1 - 1.2e-19 70.0 0.0 1.8e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 DUF3538 PF12057.3 KOG98309.1 - 0.031 13.8 0.0 0.058 13.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3538) TRAM_LAG1_CLN8 PF03798.11 KOG98310.1 - 4.4e-33 114.4 24.7 4.4e-33 114.4 17.1 2.1 2 1 0 2 2 2 1 TLC domain TRAM1 PF08390.6 KOG98310.1 - 3.7e-24 83.9 2.5 8.8e-24 82.7 1.7 1.7 1 0 0 1 1 1 1 TRAM1-like protein MOSP_C PF02722.10 KOG98310.1 - 0.062 12.8 0.1 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Major Outer Sheath Protein C-terminal region F-actin_cap_A PF01267.12 KOG98311.1 - 1.6e-80 270.1 0.4 1.8e-80 269.9 0.3 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit Tape_meas_lam_C PF09718.5 KOG98312.1 - 0.0011 18.8 0.2 0.0018 18.1 0.2 1.2 1 0 0 1 1 1 1 Lambda phage tail tape-measure protein (Tape_meas_lam_C) SF-assemblin PF06705.6 KOG98312.1 - 0.11 11.5 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 SF-assemblin/beta giardin Ribosomal_L14e PF01929.12 KOG98313.1 - 4.4e-32 110.2 0.3 7.6e-32 109.4 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.24 KOG98313.1 - 0.00055 19.5 0.4 0.0012 18.4 0.3 1.6 1 0 0 1 1 1 1 KOW motif TFIIS_M PF07500.9 KOG98314.1 - 4.9e-21 74.9 1.1 1.3e-20 73.5 0.8 1.8 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.24 KOG98314.1 - 9.6e-10 38.0 6.9 1.9e-09 37.0 4.8 1.5 1 0 0 1 1 1 1 PHD-finger SPOC PF07744.8 KOG98314.1 - 1.1e-08 35.6 0.1 1.4e-06 28.7 0.0 3.2 3 0 0 3 3 3 1 SPOC domain RAG2_PHD PF13341.1 KOG98314.1 - 0.015 15.2 1.3 0.032 14.1 0.9 1.5 1 0 0 1 1 1 0 RAG2 PHD domain PAP2 PF01569.16 KOG98315.1 - 6.8e-12 45.1 6.7 6.8e-12 45.1 4.6 2.3 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.1 KOG98315.1 - 0.0007 19.1 7.7 0.0007 19.1 5.4 2.4 2 1 0 2 2 2 1 PAP2 superfamily Ribosomal_S6 PF01250.12 KOG98316.1 - 2.4e-06 27.3 0.1 3.1e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S6 Snf7 PF03357.16 KOG98317.1 - 5.3e-18 64.9 10.5 5e-17 61.8 7.7 1.8 2 0 0 2 2 2 1 Snf7 DUF1002 PF06207.6 KOG98317.1 - 0.098 11.9 0.9 0.13 11.5 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) APS_kinase PF01583.15 KOG98318.1 - 1.6e-73 245.5 0.0 1.9e-73 245.3 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.1 KOG98318.1 - 1.4e-08 34.6 0.0 2.4e-08 33.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOG98318.1 - 1.5e-05 25.7 0.1 2.3e-05 25.1 0.1 1.4 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 KOG98318.1 - 8.7e-05 21.8 0.0 9.3e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.1 KOG98318.1 - 0.0001 22.6 0.1 0.0002 21.6 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 KOG98318.1 - 0.00017 21.0 0.0 0.00027 20.3 0.0 1.2 1 0 0 1 1 1 1 P-loop containing region of AAA domain CPT PF07931.7 KOG98318.1 - 0.0077 15.8 0.5 0.28 10.7 0.4 2.4 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_21 PF13304.1 KOG98318.1 - 0.016 15.1 0.1 0.021 14.7 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 KOG98318.1 - 0.02 15.2 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 KOG98318.1 - 0.058 13.6 0.0 0.074 13.3 0.0 1.2 1 0 0 1 1 1 0 ABC transporter PRK PF00485.13 KOG98318.1 - 0.075 12.5 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.7 KOG98318.1 - 0.098 11.7 0.0 0.25 10.4 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin AAA_16 PF13191.1 KOG98318.1 - 0.11 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Dynamin_M PF01031.15 KOG98319.1 - 9.7e-107 356.1 0.3 2.2e-106 354.9 0.2 1.6 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 KOG98319.1 - 9.8e-58 194.6 0.1 2.8e-57 193.1 0.1 1.8 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 KOG98319.1 - 9.2e-27 92.7 4.9 2.5e-26 91.3 3.4 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 KOG98319.1 - 0.0008 19.3 0.2 0.02 14.8 0.1 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KOG98319.1 - 0.024 15.1 0.0 0.07 13.6 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein ABC_tran PF00005.22 KOG98319.1 - 0.068 13.4 0.3 0.59 10.4 0.0 2.4 2 1 1 3 3 3 0 ABC transporter RNA_pol_Rpb4 PF03874.11 KOG98319.1 - 0.37 10.8 5.9 5.2 7.0 0.1 3.7 4 0 0 4 4 4 0 RNA polymerase Rpb4 PAP_central PF04928.12 KOG98320.1 - 3.8e-107 356.8 0.0 9e-107 355.6 0.0 1.6 2 0 0 2 2 2 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 KOG98320.1 - 3.1e-48 163.2 0.3 5e-48 162.5 0.2 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 KOG98320.1 - 2.6e-11 43.7 0.1 7.9e-11 42.1 0.1 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain Oxysterol_BP PF01237.13 KOG98321.1 - 1.8e-92 309.6 0.2 2.3e-92 309.2 0.1 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein PPTA PF01239.17 KOG98322.1 - 0.28 10.5 3.3 2.8 7.4 2.1 3.0 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat Nop14 PF04147.7 KOG98323.1 - 0.0016 16.4 10.5 0.0016 16.4 7.2 2.4 3 0 0 3 3 3 1 Nop14-like family Adenosine_kin PF04008.9 KOG98323.1 - 0.061 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Adenosine specific kinase ROK PF00480.15 KOG98323.1 - 0.57 9.9 3.9 1.2 8.9 2.7 1.5 1 0 0 1 1 1 0 ROK family Ribosomal_L50 PF10501.4 KOG98324.1 - 9.1e-23 80.3 1.7 1.2e-22 79.9 0.4 1.8 2 0 0 2 2 2 1 Ribosomal subunit 39S LAMTOR PF15454.1 KOG98325.1 - 1.3e-13 51.0 3.3 1.3e-13 51.0 2.3 1.8 1 1 1 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator T2SS-T3SS_pil_N PF13629.1 KOG98325.1 - 0.03 13.8 0.1 0.043 13.3 0.1 1.3 1 0 0 1 1 1 0 Pilus formation protein N terminal region SDA1 PF05285.7 KOG98325.1 - 0.038 13.2 11.4 0.052 12.8 7.9 1.2 1 0 0 1 1 1 0 SDA1 Bromodomain PF00439.20 KOG98326.1 - 3.1e-31 107.1 6.1 2.3e-19 69.0 0.2 2.7 2 0 0 2 2 2 2 Bromodomain adh_short PF00106.20 KOG98327.1 - 3.7e-63 212.3 4.6 1.3e-31 109.8 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase MaoC_dehydratas PF01575.14 KOG98327.1 - 5.9e-35 119.3 0.0 1.1e-34 118.4 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain KR PF08659.5 KOG98327.1 - 8.6e-33 113.5 1.2 7.8e-16 58.2 0.0 2.2 2 0 0 2 2 2 2 KR domain adh_short_C2 PF13561.1 KOG98327.1 - 4.3e-19 69.2 0.7 2.2e-10 40.7 0.1 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydrat_N PF13452.1 KOG98327.1 - 7.9e-07 28.9 0.0 5.8e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase DUF2099 PF09872.4 KOG98327.1 - 0.045 12.7 0.3 0.13 11.2 0.1 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2099) 3HCDH_N PF02737.13 KOG98327.1 - 0.16 11.5 4.1 1.5 8.4 0.0 2.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Cytokin_check_N PF10407.4 KOG98328.1 - 1.2e-27 95.2 1.3 6.1e-27 93.0 0.9 2.3 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus CAP PF00188.21 KOG98330.1 - 4.3e-17 62.7 4.5 4.3e-17 62.7 3.1 1.8 2 1 0 2 2 2 1 Cysteine-rich secretory protein family FAM196 PF15265.1 KOG98330.1 - 1.3 8.1 20.4 1.6 7.9 14.2 1.1 1 0 0 1 1 1 0 FAM196 family Herpes_UL32 PF06070.6 KOG98330.1 - 1.6 7.1 26.0 1.8 6.8 18.0 1.1 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 DUF605 PF04652.11 KOG98330.1 - 5 6.4 33.5 6.9 5.9 23.2 1.2 1 0 0 1 1 1 0 Vta1 like CytochromB561_N PF09786.4 KOG98330.1 - 7.4 4.8 22.7 8.7 4.6 15.8 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal DUF566 PF04484.7 KOG98330.1 - 9.1 5.6 28.3 14 5.0 19.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF566) Ras PF00071.17 KOG98331.1 - 7.6e-55 184.7 0.2 9.3e-55 184.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG98331.1 - 7.3e-21 74.8 0.3 1.4e-20 73.9 0.0 1.6 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 KOG98331.1 - 8.9e-13 47.8 0.1 1.7e-12 46.9 0.1 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOG98331.1 - 1.7e-05 24.1 0.0 2.7e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOG98331.1 - 3.1e-05 23.4 0.0 5.8e-05 22.6 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOG98331.1 - 0.00011 22.1 0.1 0.00022 21.1 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 KOG98331.1 - 0.042 13.8 0.3 0.099 12.6 0.2 1.9 1 1 1 2 2 2 0 AAA ATPase domain Septin PF00735.13 KOG98331.1 - 0.06 12.3 0.0 0.11 11.4 0.0 1.4 1 0 0 1 1 1 0 Septin DUF258 PF03193.11 KOG98331.1 - 0.064 12.4 0.2 0.14 11.3 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF258 FYDLN_acid PF09538.5 KOG98331.1 - 0.29 11.7 2.3 0.69 10.5 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Mitofilin PF09731.4 KOG98333.1 - 7.2e-132 440.9 21.4 2e-112 376.7 13.8 2.0 1 1 1 2 2 2 2 Mitochondrial inner membrane protein HDAC4_Gln PF12203.3 KOG98333.1 - 0.16 11.9 12.4 0.21 11.5 7.4 2.0 1 1 1 2 2 2 0 Glutamine rich N terminal domain of histone deacetylase 4 YjcZ PF13990.1 KOG98333.1 - 2.5 7.1 12.5 2.7 7.0 5.0 2.6 2 1 1 3 3 3 0 YjcZ-like protein IncA PF04156.9 KOG98333.1 - 6.2 6.3 20.4 1.1 8.7 7.0 2.4 2 0 0 2 2 2 0 IncA protein IBR PF01485.16 KOG98334.1 - 1.9e-18 66.0 39.6 5.9e-10 38.8 7.5 3.8 3 1 0 3 3 3 2 IBR domain zf-C3HC4 PF00097.20 KOG98334.1 - 2.3e-05 23.9 13.8 2.3e-05 23.9 9.5 4.7 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOG98334.1 - 0.0023 17.9 12.4 0.0023 17.9 8.6 5.3 5 0 0 5 5 5 3 Zinc finger, C3HC4 type (RING finger) VGCC_alpha2 PF08473.6 KOG98334.1 - 0.067 12.9 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 Neuronal voltage-dependent calcium channel alpha 2acd DUF3808 PF10300.4 KOG98335.1 - 6.3e-174 578.9 0.1 7.4e-174 578.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_16 PF13432.1 KOG98335.1 - 0.0064 17.1 3.3 0.59 10.8 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOG98335.1 - 0.02 14.7 0.8 33 4.7 0.0 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOG98335.1 - 0.075 12.8 1.0 17 5.3 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat EF-hand_4 PF12763.2 KOG98336.1 - 0.019 14.7 0.7 0.054 13.2 0.0 2.1 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Vps51 PF08700.6 KOG98337.1 - 1.7e-10 40.5 4.8 1.7e-10 40.5 3.3 1.7 2 0 0 2 2 2 1 Vps51/Vps67 HBS1_N PF08938.5 KOG98337.1 - 0.006 16.6 1.5 0.011 15.8 1.0 1.5 1 1 0 1 1 1 1 HBS1 N-terminus DUF1870 PF08965.5 KOG98337.1 - 0.025 14.2 0.2 0.045 13.4 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1870) Arrestin_C PF02752.17 KOG98338.1 - 2.5e-17 63.2 3.8 4.9e-15 55.8 0.1 3.2 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 KOG98338.1 - 2.9e-08 33.6 0.1 0.00012 21.9 0.1 2.8 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain NTR2 PF15458.1 KOG98339.1 - 1.3e-38 132.6 19.4 1.7e-38 132.3 13.4 1.1 1 0 0 1 1 1 1 Nineteen complex-related protein 2 Ribosomal_L14e PF01929.12 KOG98339.1 - 0.07 13.4 1.6 0.25 11.7 0.1 2.4 2 0 0 2 2 2 0 Ribosomal protein L14 zf-C2HC5 PF06221.8 KOG98340.1 - 2.6e-19 68.7 8.2 4.7e-19 67.8 5.7 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type zf-ribbon_3 PF13248.1 KOG98340.1 - 2.6 7.3 6.9 11 5.3 4.8 2.0 1 1 1 2 2 2 0 zinc-ribbon domain DUF3782 PF12644.2 KOG98340.1 - 3.7 7.4 8.8 0.82 9.5 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3782) DEAD PF00270.24 KOG98341.1 - 5.8e-40 136.5 0.0 1.2e-39 135.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.1 KOG98341.1 - 4.6e-19 67.7 0.0 1.2e-18 66.3 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 KOG98341.1 - 4.3e-17 61.7 0.0 9.1e-17 60.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOG98341.1 - 8e-06 25.8 0.5 1.8e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KOG98341.1 - 0.02 13.6 0.0 0.036 12.8 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain Sin_N PF04801.8 KOG98342.1 - 1.3e-16 60.5 0.5 1.3e-16 60.5 0.4 1.8 2 1 0 2 2 2 1 Sin-like protein conserved region MRP-L27 PF09809.4 KOG98342.1 - 0.09 12.3 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L27 IF-2B PF01008.12 KOG98343.1 - 4.2e-81 272.0 0.0 4.8e-81 271.8 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DeoRC PF00455.17 KOG98343.1 - 0.046 13.3 0.1 4.4 6.9 0.0 2.4 2 0 0 2 2 2 0 DeoR C terminal sensor domain ChAPs PF09295.5 KOG98344.1 - 9.1e-43 146.5 4.6 7.4e-35 120.4 0.8 2.1 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_11 PF13414.1 KOG98344.1 - 3.9e-05 23.1 0.0 0.0094 15.5 0.0 2.4 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOG98344.1 - 0.01 15.6 0.0 4.1 7.5 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Apc3 PF12895.2 KOG98344.1 - 0.046 13.8 0.0 0.77 9.9 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 KOG98344.1 - 0.14 12.8 0.0 33 5.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat SAPS PF04499.10 KOG98345.1 - 6.6e-167 555.9 2.2 6.6e-167 555.9 1.5 3.1 3 0 0 3 3 3 1 SIT4 phosphatase-associated protein PHD PF00628.24 KOG98346.1 - 9.6e-11 41.2 9.0 1.9e-10 40.2 6.2 1.5 1 0 0 1 1 1 1 PHD-finger SET PF00856.23 KOG98346.1 - 1.4e-05 25.4 0.1 1.4e-05 25.4 0.1 3.0 3 2 0 3 3 3 1 SET domain PHD_2 PF13831.1 KOG98346.1 - 0.00053 19.2 3.8 0.0011 18.2 2.6 1.5 1 0 0 1 1 1 1 PHD-finger UNC-50 PF05216.8 KOG98347.1 - 8.9e-91 303.2 20.3 1e-90 303.0 14.1 1.0 1 0 0 1 1 1 1 UNC-50 family UPF0542 PF15086.1 KOG98347.1 - 2.9 7.6 0.0 2.9 7.6 0.0 2.9 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 PLDc PF00614.17 KOG98348.1 - 7e-19 66.9 0.1 3.5e-09 36.1 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.1 KOG98348.1 - 3e-09 36.6 4.5 1.2e-06 28.3 0.0 3.9 4 0 0 4 4 4 2 PLD-like domain PX PF00787.19 KOG98348.1 - 0.00089 19.0 5.0 0.004 16.9 0.5 3.5 3 0 0 3 3 3 1 PX domain GATA PF00320.22 KOG98349.1 - 3.8e-15 54.9 1.0 7.2e-15 54.0 0.7 1.5 1 0 0 1 1 1 1 GATA zinc finger ArfGap PF01412.13 KOG98349.1 - 0.0076 16.0 0.7 0.013 15.2 0.5 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf TF_Zn_Ribbon PF08271.7 KOG98349.1 - 0.1 11.9 0.4 0.21 10.9 0.3 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Snf7 PF03357.16 KOG98350.1 - 5.1e-15 55.2 20.0 5.1e-15 55.2 13.9 1.4 2 0 0 2 2 2 1 Snf7 DUF2580 PF10824.3 KOG98350.1 - 0.059 13.7 1.7 0.065 13.5 0.0 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2580) FKBP_C PF00254.23 KOG98350.1 - 0.088 12.8 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase GrpE PF01025.14 KOG98350.1 - 0.33 10.4 12.5 0.07 12.6 6.2 1.7 1 1 1 2 2 2 0 GrpE ALMT PF11744.3 KOG98350.1 - 0.71 8.4 10.6 0.11 11.1 0.5 2.0 1 1 1 2 2 2 0 Aluminium activated malate transporter SYCE1 PF15233.1 KOG98350.1 - 5.9 6.8 14.8 13 5.7 10.2 1.7 1 1 0 1 1 1 0 Synaptonemal complex central element protein 1 WD40 PF00400.27 KOG98351.1 - 2.5e-35 119.0 5.9 1e-10 41.0 0.0 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat DUF3249 PF11615.3 KOG98351.1 - 5.8e-27 93.1 0.2 1.2e-26 92.2 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3249) Nup160 PF11715.3 KOG98351.1 - 0.00055 18.2 4.3 0.35 8.9 0.0 4.3 2 2 3 5 5 5 3 Nucleoporin Nup120/160 DASH_Spc34 PF08657.5 KOG98352.1 - 6.7e-76 255.3 0.6 7.6e-76 255.1 0.4 1.0 1 0 0 1 1 1 1 DASH complex subunit Spc34 TMF_TATA_bd PF12325.3 KOG98352.1 - 0.041 13.5 1.5 0.72 9.5 0.2 2.8 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF904 PF06005.7 KOG98352.1 - 0.079 13.2 3.8 4.1 7.7 0.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF904) Cep57_MT_bd PF06657.8 KOG98352.1 - 0.081 12.8 1.6 1.8 8.5 0.1 2.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 HRDC PF00570.18 KOG98352.1 - 0.083 12.6 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 HRDC domain Syntaxin PF00804.20 KOG98352.1 - 0.091 12.9 1.1 2.2 8.4 0.9 2.5 2 0 0 2 2 2 0 Syntaxin PaaX_C PF08223.6 KOG98352.1 - 0.096 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 PaaX-like protein C-terminal domain Peptidase_M22 PF00814.20 KOG98353.1 - 1.1e-84 284.1 0.0 1.3e-84 283.8 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family CmcH_NodU PF02543.10 KOG98353.1 - 0.017 14.3 0.1 0.023 13.8 0.0 1.1 1 0 0 1 1 1 0 Carbamoyltransferase Staygreen PF12638.2 KOG98353.1 - 0.025 14.1 0.0 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 Staygreen protein AA_permease PF00324.16 KOG98354.1 - 2.7e-154 514.0 36.4 3.1e-154 513.8 25.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG98354.1 - 1.5e-41 142.3 37.0 2.1e-41 141.8 25.7 1.0 1 0 0 1 1 1 1 Amino acid permease DnaJ PF00226.26 KOG98355.1 - 0.058 13.1 0.1 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 DnaJ domain SUN PF03856.8 KOG98356.1 - 7.8e-103 343.1 18.2 1.2e-102 342.5 12.6 1.3 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) His_Phos_1 PF00300.17 KOG98357.1 - 9.8e-28 97.2 0.1 1.3e-27 96.8 0.1 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 KOG98357.1 - 0.022 14.1 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Lectin_leg-like PF03388.8 KOG98358.1 - 9.4e-16 57.6 0.0 5.4e-07 28.9 0.0 2.2 2 0 0 2 2 2 2 Legume-like lectin family Lectin_legB PF00139.14 KOG98358.1 - 9.4e-06 25.1 0.4 2.2e-05 23.9 0.3 1.6 1 1 0 1 1 1 1 Legume lectin domain Med15 PF09606.5 KOG98359.1 - 0.0011 17.2 10.2 0.0014 16.9 7.1 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal CagX PF03524.10 KOG98359.1 - 0.011 15.0 3.8 0.024 13.9 2.6 1.5 1 0 0 1 1 1 0 Conjugal transfer protein Suf PF05843.9 KOG98359.1 - 0.074 12.7 4.3 0.079 12.6 3.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) BAF1_ABF1 PF04684.8 KOG98359.1 - 1.7 7.4 11.8 2.1 7.1 8.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor ERF PF04404.7 KOG98359.1 - 2.2 7.7 10.5 4.1 6.9 7.3 1.4 1 0 0 1 1 1 0 ERF superfamily NAP PF00956.13 KOG98361.1 - 5.3e-78 261.5 4.4 5.3e-78 261.5 3.0 2.6 3 0 0 3 3 3 1 Nucleosome assembly protein (NAP) DUF1687 PF07955.6 KOG98362.1 - 7.3e-42 142.5 0.8 8.6e-42 142.2 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) ATP-gua_PtransN PF02807.10 KOG98362.1 - 0.054 13.6 0.0 0.17 12.0 0.0 1.8 2 1 0 2 2 2 0 ATP:guanido phosphotransferase, N-terminal domain TrkH PF02386.11 KOG98363.1 - 6.6e-146 485.4 9.5 1.1e-143 478.0 1.0 2.1 2 0 0 2 2 2 2 Cation transport protein Solute_trans_a PF03619.11 KOG98364.1 - 1.1e-86 290.5 10.8 1.4e-86 290.2 7.5 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Mito_carr PF00153.22 KOG98365.1 - 1.3e-61 204.2 2.3 3e-21 74.9 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein PAP2 PF01569.16 KOG98366.1 - 1e-11 44.5 2.7 1e-11 44.5 1.9 2.1 1 1 1 2 2 2 1 PAP2 superfamily CD52 PF15116.1 KOG98366.1 - 0.087 12.6 3.0 0.074 12.8 0.8 1.9 1 1 1 2 2 2 0 CAMPATH-1 antigen Fer4_5 PF12801.2 KOG98366.1 - 0.56 10.0 8.2 0.17 11.6 2.6 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain 2TM PF13239.1 KOG98366.1 - 3.5 7.7 7.2 0.39 10.8 0.5 2.5 2 0 0 2 2 2 0 2TM domain DHC_N1 PF08385.7 KOG98367.1 - 9.1e-100 334.7 33.2 9.1e-100 334.7 23.0 6.4 8 1 0 8 8 7 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 KOG98367.1 - 1e-89 300.9 17.3 1e-89 300.9 12.0 6.5 8 1 1 9 9 7 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOG98367.1 - 1.4e-57 194.9 0.0 3.2e-57 193.7 0.0 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 Dynein_heavy PF03028.10 KOG98367.1 - 2.9e-35 121.4 0.3 2.9e-35 121.4 0.2 2.7 2 0 0 2 2 1 1 Dynein heavy chain and region D6 of dynein motor AAA_8 PF12780.2 KOG98367.1 - 5.6e-27 94.3 0.2 1.6e-26 92.8 0.1 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_5 PF07728.9 KOG98367.1 - 1.7e-23 82.8 2.9 1.1e-06 28.4 0.0 7.0 6 1 0 6 6 6 3 AAA domain (dynein-related subfamily) AAA_9 PF12781.2 KOG98367.1 - 2e-23 82.4 1.1 2e-23 82.4 0.8 2.5 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 MT PF12777.2 KOG98367.1 - 3.8e-23 81.7 9.1 7.8e-23 80.7 6.3 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 KOG98367.1 - 3.7e-17 62.3 0.1 7e-16 58.1 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA PF00004.24 KOG98367.1 - 9.2e-14 51.7 12.5 0.0013 18.9 0.0 8.5 8 0 0 8 8 8 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOG98367.1 - 1.2e-13 51.3 11.9 0.00014 21.9 0.0 8.2 7 1 0 7 7 6 4 AAA domain AAA_16 PF13191.1 KOG98367.1 - 1.6e-11 44.5 0.2 0.22 11.4 0.0 6.2 5 1 1 6 6 6 3 AAA ATPase domain Zeta_toxin PF06414.7 KOG98367.1 - 3.2e-08 32.9 0.0 0.013 14.6 0.0 3.9 4 0 0 4 4 3 2 Zeta toxin AAA_17 PF13207.1 KOG98367.1 - 1.9e-06 28.6 3.8 0.29 11.9 0.0 5.9 5 0 0 5 5 3 1 AAA domain AAA_33 PF13671.1 KOG98367.1 - 1e-05 25.4 0.1 0.16 11.8 0.0 4.8 4 0 0 4 4 4 1 AAA domain AAA_30 PF13604.1 KOG98367.1 - 4.5e-05 23.1 2.1 1.7 8.1 0.0 4.5 4 1 1 5 5 5 1 AAA domain AAA_28 PF13521.1 KOG98367.1 - 6.8e-05 22.8 0.4 0.99 9.3 0.0 4.1 4 0 0 4 4 3 1 AAA domain IstB_IS21 PF01695.12 KOG98367.1 - 7.2e-05 22.2 0.2 0.31 10.4 0.0 4.2 3 0 0 3 3 3 1 IstB-like ATP binding protein RNA_helicase PF00910.17 KOG98367.1 - 7.3e-05 22.8 0.3 4.4 7.5 0.0 4.9 4 0 0 4 4 4 1 RNA helicase AAA_19 PF13245.1 KOG98367.1 - 9.4e-05 22.0 0.6 3.2 7.5 0.0 4.3 4 0 0 4 4 4 1 Part of AAA domain ABC_tran PF00005.22 KOG98367.1 - 0.0025 18.1 3.0 0.99 9.6 0.0 5.1 5 0 0 5 5 4 1 ABC transporter FtsK_SpoIIIE PF01580.13 KOG98367.1 - 0.0041 16.6 0.2 19 4.6 0.0 4.2 5 0 0 5 5 5 0 FtsK/SpoIIIE family Mg_chelatase PF01078.16 KOG98367.1 - 0.011 14.9 0.5 0.93 8.6 0.0 3.5 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 KOG98367.1 - 0.045 14.0 17.3 1.5 9.1 0.0 6.6 6 0 0 6 6 6 0 AAA domain AAA_25 PF13481.1 KOG98367.1 - 0.067 12.5 0.2 7.2 5.9 0.0 3.5 4 0 0 4 4 3 0 AAA domain Ras PF00071.17 KOG98368.1 - 8.5e-52 174.7 0.0 1.3e-51 174.1 0.0 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG98368.1 - 1.8e-17 63.9 0.0 3.6e-17 62.9 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOG98368.1 - 3.3e-06 26.4 0.0 5.7e-06 25.6 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family tRNA_U5-meth_tr PF05958.6 KOG98369.1 - 1e-21 77.0 0.2 1.3e-20 73.3 0.2 2.1 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase TRAM PF01938.15 KOG98369.1 - 3.8e-11 42.5 0.3 7.6e-11 41.6 0.0 1.7 2 0 0 2 2 1 1 TRAM domain Methyltransf_31 PF13847.1 KOG98369.1 - 1.1e-09 38.0 0.2 3.2e-09 36.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOG98369.1 - 3.9e-07 30.6 0.0 1.4e-06 28.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 KOG98369.1 - 5.3e-06 25.7 0.0 1.2e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.5 KOG98369.1 - 9.8e-06 25.2 0.0 2.3e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.10 KOG98369.1 - 2e-05 24.0 0.2 5.4e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_26 PF13659.1 KOG98369.1 - 4.5e-05 23.4 0.0 8.3e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOG98369.1 - 0.00012 21.4 0.0 0.00029 20.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.12 KOG98369.1 - 0.00047 19.2 0.0 0.0013 17.7 0.0 1.7 1 0 0 1 1 1 1 Putative methyltransferase Met_10 PF02475.11 KOG98369.1 - 0.00059 19.4 0.3 0.0028 17.2 0.0 2.1 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_11 PF08241.7 KOG98369.1 - 0.00074 19.9 0.0 0.016 15.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOG98369.1 - 0.0011 19.3 0.0 0.009 16.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOG98369.1 - 0.0021 17.2 0.0 0.0054 15.8 0.0 1.7 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Ribosomal_S21e PF01249.13 KOG98370.1 - 7.5e-40 134.7 0.0 8.3e-40 134.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Glyco_transf_8 PF01501.15 KOG98371.1 - 5.3e-38 130.7 0.1 1.1e-37 129.7 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 8 PRO8NT PF08082.6 KOG98371.1 - 0.64 9.6 4.9 0.34 10.5 0.3 2.6 3 0 0 3 3 3 0 PRO8NT (NUC069), PrP8 N-terminal domain DEAD PF00270.24 KOG98372.1 - 6e-42 143.0 1.9 1.7e-41 141.5 0.3 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG98372.1 - 4e-28 97.0 0.2 3e-27 94.2 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOG98372.1 - 1.1e-05 25.3 0.0 2.7e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 KOG98372.1 - 0.00054 19.6 0.2 0.0018 17.9 0.1 1.8 2 0 0 2 2 2 1 Part of AAA domain DUF1253 PF06862.7 KOG98372.1 - 0.011 14.1 0.3 1.3 7.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1253) Helicase_C_2 PF13307.1 KOG98372.1 - 0.025 14.5 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain AAA_30 PF13604.1 KOG98372.1 - 0.064 12.8 0.2 0.23 10.9 0.1 1.9 2 1 0 2 2 2 0 AAA domain Ribosomal_L1 PF00687.16 KOG98373.1 - 5.9e-45 153.2 3.6 7.1e-45 153.0 2.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Glyco_transf_15 PF01793.11 KOG98374.1 - 1.7e-129 431.5 12.6 2.1e-129 431.2 8.8 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase TFIIE_beta PF02186.10 KOG98375.1 - 1.4e-23 82.6 0.7 3.2e-23 81.5 0.5 1.6 1 0 0 1 1 1 1 TFIIE beta subunit core domain Las1 PF04031.8 KOG98376.1 - 1.5e-53 180.6 0.0 2.9e-53 179.6 0.0 1.5 1 0 0 1 1 1 1 Las1-like DUF4111 PF13427.1 KOG98376.1 - 0.01 15.6 0.7 0.048 13.4 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4111) Secretin_N_2 PF07655.8 KOG98376.1 - 1.3 9.4 4.2 1.7 9.0 0.1 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain Pam17 PF08566.5 KOG98377.1 - 1.8e-71 239.4 0.0 2.1e-71 239.1 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 BPD_transp_2 PF02653.11 KOG98377.1 - 0.0088 15.0 0.0 0.012 14.5 0.0 1.1 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component DUF1086 PF06461.6 KOG98377.1 - 0.08 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1086) peroxidase PF00141.18 KOG98378.1 - 6e-44 150.2 0.0 1e-43 149.4 0.0 1.4 1 0 0 1 1 1 1 Peroxidase Acyltransferase PF01553.16 KOG98379.1 - 3.6e-06 26.4 0.0 2.8e-05 23.5 0.0 2.3 1 1 0 1 1 1 1 Acyltransferase TRAPP PF04051.11 KOG98380.1 - 4e-38 130.3 0.0 4.8e-38 130.0 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Dsl1_N PF11988.3 KOG98380.1 - 0.0023 16.8 0.3 0.0049 15.7 0.0 1.7 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 N terminal TP_methylase PF00590.15 KOG98381.1 - 1.9e-38 132.3 0.0 3e-38 131.6 0.0 1.4 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.1 KOG98381.1 - 0.00043 20.4 0.0 0.0014 18.8 0.0 1.8 2 0 0 2 2 2 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.1 KOG98381.1 - 0.00073 18.4 0.0 0.0017 17.2 0.0 1.7 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central CTF_NFI PF00859.13 KOG98381.1 - 0.15 11.7 1.1 0.24 11.1 0.8 1.2 1 0 0 1 1 1 0 CTF/NF-I family transcription modulation region Hydrolase_6 PF13344.1 KOG98382.1 - 2.8e-25 88.1 0.0 4.9e-25 87.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOG98382.1 - 1.6e-24 85.3 0.0 3.9e-24 84.1 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.1 KOG98382.1 - 9.9e-05 22.6 0.1 0.38 10.9 0.0 3.1 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOG98382.1 - 0.00023 21.6 0.0 0.002 18.6 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase CIAPIN1 PF05093.8 KOG98383.1 - 1.3e-36 124.6 5.9 3.7e-36 123.2 4.1 1.8 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis YL1 PF05764.8 KOG98383.1 - 0.86 9.1 12.1 1.7 8.1 8.4 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Flavoprotein PF02441.14 KOG98384.1 - 3.4e-44 149.6 0.1 6.4e-44 148.7 0.0 1.5 1 0 0 1 1 1 1 Flavoprotein CENP-T PF15511.1 KOG98384.1 - 0.24 10.6 22.3 0.18 10.9 13.6 2.0 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T Tim54 PF11711.3 KOG98384.1 - 0.29 9.6 11.3 0.029 12.9 3.6 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 BUD22 PF09073.5 KOG98384.1 - 0.46 9.5 29.2 0.1 11.6 16.3 2.3 2 0 0 2 2 2 0 BUD22 DUF1510 PF07423.6 KOG98384.1 - 0.51 9.6 25.5 1.4 8.2 17.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) FLO_LFY PF01698.11 KOG98384.1 - 0.95 8.2 6.8 1.6 7.4 4.7 1.3 1 0 0 1 1 1 0 Floricaula / Leafy protein CDC45 PF02724.9 KOG98384.1 - 6.1 4.7 28.5 14 3.5 19.7 1.5 1 0 0 1 1 1 0 CDC45-like protein VID27 PF08553.5 KOG98384.1 - 7 4.7 17.7 2 6.5 10.1 1.7 2 0 0 2 2 2 0 VID27 cytoplasmic protein DUF2340 PF10209.4 KOG98385.1 - 5.5e-58 194.4 2.6 7.2e-58 194.0 1.8 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) Peptidase_C13 PF01650.13 KOG98385.1 - 0.0057 15.9 0.5 0.0091 15.3 0.3 1.4 1 1 1 2 2 2 1 Peptidase C13 family Ubiquitin_2 PF14560.1 KOG98385.1 - 0.11 12.7 0.2 0.22 11.8 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain Zip PF02535.17 KOG98386.1 - 0.64 8.9 4.8 0.8 8.6 3.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter GST_N_2 PF13409.1 KOG98387.1 - 5.6e-24 83.9 0.0 1.3e-23 82.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOG98387.1 - 1.6e-10 40.7 0.0 3.3e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 KOG98387.1 - 0.00093 19.3 0.1 0.6 10.3 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 KOG98387.1 - 0.063 13.2 0.1 0.3 11.1 0.1 2.0 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOG98387.1 - 0.072 13.5 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Vps5 PF09325.5 KOG98389.1 - 5e-25 88.1 11.0 8.5e-25 87.3 7.7 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 KOG98389.1 - 3.6e-14 52.5 0.5 3.6e-14 52.5 0.4 3.2 3 1 1 4 4 4 1 PX domain Lactamase_B_2 PF12706.2 KOG98390.1 - 8.2e-39 133.1 0.3 2e-38 131.8 0.2 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.1 KOG98390.1 - 7.8e-24 82.9 0.0 1.5e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B PF00753.22 KOG98390.1 - 0.027 14.1 0.1 0.063 12.9 0.0 1.6 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily THF_DHG_CYH_C PF02882.14 KOG98391.1 - 6.8e-18 64.2 0.1 7.5e-11 41.3 0.0 2.6 1 1 1 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 KOG98391.1 - 1.1e-16 60.9 0.1 5.2e-16 58.7 0.0 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain RTP PF02334.11 KOG98391.1 - 0.053 13.4 0.2 0.23 11.4 0.0 2.0 1 1 1 2 2 2 0 Replication terminator protein Brix PF04427.13 KOG98392.1 - 1.5e-38 132.3 1.3 2e-38 131.9 0.9 1.2 1 0 0 1 1 1 1 Brix domain Nucleoporin_C PF03177.9 KOG98393.1 - 4.2e-62 210.5 19.1 5.8e-62 210.0 13.2 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 KOG98393.1 - 4.1e-57 193.8 10.3 6.3e-57 193.2 7.1 1.3 1 0 0 1 1 1 1 Nup133 N terminal like CHAP PF05257.11 KOG98393.1 - 0.096 12.3 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 CHAP domain DASH_Dad2 PF08654.5 KOG98394.1 - 8e-28 96.4 7.4 4e-26 90.9 5.2 2.0 1 1 0 1 1 1 1 DASH complex subunit Dad2 DASH_Duo1 PF08651.5 KOG98394.1 - 0.00033 20.1 1.7 0.00057 19.4 1.2 1.3 1 0 0 1 1 1 1 DASH complex subunit Duo1 DHC_N2 PF08393.8 KOG98394.1 - 0.003 16.1 1.6 0.0036 15.8 1.1 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 PBP1_TM PF14812.1 KOG98394.1 - 0.21 11.9 4.1 0.41 10.9 2.8 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.5 KOG98394.1 - 0.47 10.7 6.2 0.74 10.0 4.3 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF3585 PF12130.3 KOG98394.1 - 2.8 7.8 10.8 0.12 12.1 0.5 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3585) GTP_EFTU PF00009.22 KOG98395.1 - 4e-44 150.3 0.0 6.7e-44 149.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.5 KOG98395.1 - 9.1e-14 51.3 3.4 9.1e-14 51.3 2.4 2.1 2 0 0 2 2 2 1 HBS1 N-terminus MMR_HSR1 PF01926.18 KOG98395.1 - 8.1e-07 29.0 0.0 1.1e-05 25.3 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D3 PF03143.12 KOG98395.1 - 2.8e-05 24.1 0.0 0.00014 21.9 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 KOG98395.1 - 0.00012 22.0 0.1 0.00037 20.5 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Miro PF08477.8 KOG98395.1 - 0.0013 19.2 0.0 0.011 16.2 0.0 2.4 1 1 0 1 1 1 1 Miro-like protein Dynamin_N PF00350.18 KOG98395.1 - 0.0016 18.2 0.4 0.42 10.4 0.1 2.9 2 1 0 2 2 2 1 Dynamin family Ras PF00071.17 KOG98395.1 - 0.0072 15.7 0.5 0.1 12.0 0.0 2.5 3 0 0 3 3 3 1 Ras family FeoB_N PF02421.13 KOG98395.1 - 0.1 11.9 0.2 1.9 7.7 0.1 2.8 2 1 0 2 2 2 0 Ferrous iron transport protein B Dabb PF07876.7 KOG98395.1 - 0.15 12.5 0.3 89 3.6 0.0 3.5 3 0 0 3 3 3 0 Stress responsive A/B Barrel Domain MRP-L20 PF12824.2 KOG98396.1 - 2.5e-43 147.8 2.8 3e-43 147.6 2.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 HTH_38 PF13936.1 KOG98396.1 - 0.062 12.8 0.0 0.16 11.5 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Frankia_peptide PF14407.1 KOG98396.1 - 0.063 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. AIG2 PF06094.7 KOG98396.1 - 0.077 13.4 0.1 0.14 12.6 0.0 1.6 1 1 0 1 1 1 0 AIG2-like family Terminase_3 PF04466.8 KOG98396.1 - 0.087 11.8 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Phage terminase large subunit HA2 PF04408.18 KOG98397.1 - 1e-25 89.6 0.0 3.9e-25 87.8 0.0 2.1 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 KOG98397.1 - 1.3e-21 76.5 0.0 3.6e-21 75.1 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 KOG98397.1 - 3.2e-14 52.5 0.0 7.8e-14 51.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOG98397.1 - 1.7e-07 30.8 0.4 5.5e-07 29.2 0.1 2.1 2 0 0 2 2 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KOG98397.1 - 1.1e-06 28.8 0.0 4.1e-06 26.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOG98397.1 - 0.00023 20.8 0.0 0.00054 19.6 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 KOG98397.1 - 0.00042 20.2 0.6 0.017 15.0 0.4 2.9 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 KOG98397.1 - 0.0015 18.3 1.4 0.036 13.9 0.0 2.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.1 KOG98397.1 - 0.0015 18.5 0.0 0.005 16.8 0.0 1.9 1 0 0 1 1 1 1 Sigma-54 interaction domain PhoH PF02562.11 KOG98397.1 - 0.0019 17.4 0.0 0.0053 16.0 0.0 1.7 1 0 0 1 1 1 1 PhoH-like protein T2SE PF00437.15 KOG98397.1 - 0.0022 16.9 0.0 0.0043 16.0 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF2075 PF09848.4 KOG98397.1 - 0.0041 16.1 0.4 0.015 14.3 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.12 KOG98397.1 - 0.0046 16.4 0.0 2.5 7.5 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein NB-ARC PF00931.17 KOG98397.1 - 0.0087 14.9 0.1 0.015 14.1 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain ParA PF10609.4 KOG98397.1 - 0.011 15.6 0.0 1.5 8.8 0.0 3.2 3 0 0 3 3 3 0 ParA/MinD ATPase like Herpes_ori_bp PF02399.10 KOG98397.1 - 0.017 13.1 0.1 0.033 12.1 0.1 1.4 1 0 0 1 1 1 0 Origin of replication binding protein ABC_tran PF00005.22 KOG98397.1 - 0.017 15.4 0.0 0.064 13.5 0.0 2.0 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.1 KOG98397.1 - 0.017 14.7 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 KOG98397.1 - 0.023 14.3 0.6 0.071 12.8 0.0 2.1 2 0 0 2 2 1 0 Archaeal ATPase Sigma54_activat PF00158.21 KOG98397.1 - 0.034 13.6 0.0 0.077 12.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Miro PF08477.8 KOG98397.1 - 0.057 13.9 0.0 0.22 11.9 0.0 2.1 1 0 0 1 1 1 0 Miro-like protein AAA_16 PF13191.1 KOG98397.1 - 0.061 13.3 0.1 0.24 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.1 KOG98397.1 - 0.068 13.4 0.1 0.068 13.4 0.0 3.6 3 1 0 4 4 4 0 AAA domain AAA_25 PF13481.1 KOG98397.1 - 0.091 12.1 0.0 0.21 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KOG98397.1 - 0.092 12.2 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_11 PF13086.1 KOG98397.1 - 0.097 12.2 2.4 0.14 11.7 0.0 2.4 3 0 0 3 3 2 0 AAA domain Peptidase_M48 PF01435.13 KOG98398.1 - 4e-32 111.5 0.0 5.3e-32 111.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 SNARE_assoc PF09335.6 KOG98399.1 - 1.5e-15 57.4 5.3 1.5e-15 57.4 3.7 2.8 3 1 0 3 3 3 1 SNARE associated Golgi protein DUF4231 PF14015.1 KOG98399.1 - 0.082 12.9 11.5 2.4 8.1 0.1 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) Tetraspannin PF00335.15 KOG98399.1 - 0.18 11.0 4.5 7.4 5.7 3.1 2.4 2 0 0 2 2 2 0 Tetraspanin family DUF3754 PF12576.3 KOG98399.1 - 0.57 9.8 7.9 0.38 10.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3754) Cg6151-P PF10233.4 KOG98399.1 - 2 8.4 10.4 0.87 9.5 4.3 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein CG6151-P DUF3336 PF11815.3 KOG98400.1 - 2.7e-39 133.9 2.4 2.7e-39 133.9 1.7 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.17 KOG98400.1 - 4.9e-30 104.9 0.0 9.7e-30 104.0 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase LIM PF00412.17 KOG98401.1 - 7.3e-14 51.5 23.5 3.4e-08 33.4 6.1 2.4 2 0 0 2 2 2 2 LIM domain CTD PF12815.2 KOG98402.1 - 6.9 7.1 8.2 30 5.0 5.7 2.0 1 1 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 SRP40_C PF05022.7 KOG98403.1 - 1.9e-29 101.9 3.3 4.4e-29 100.8 2.3 1.7 1 0 0 1 1 1 1 SRP40, C-terminal domain PTR2 PF00854.16 KOG98404.1 - 1.8e-76 257.3 20.2 1.8e-76 257.3 14.0 1.3 2 0 0 2 2 2 1 POT family MFS_1 PF07690.11 KOG98404.1 - 2.2e-06 26.6 31.5 2.2e-06 26.6 21.8 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily TPR_MLP1_2 PF07926.7 KOG98405.1 - 8.2e-30 103.2 25.5 8.2e-30 103.2 17.7 16.3 3 3 11 16 16 16 4 TPR/MLP1/MLP2-like protein Cep57_CLD_2 PF14197.1 KOG98405.1 - 0.0015 18.4 7.3 0.0015 18.4 5.1 19.8 12 6 11 23 23 23 3 Centrosome localisation domain of PPC89 Pcc1 PF09341.5 KOG98406.1 - 4.1e-23 81.2 0.0 4.5e-23 81.0 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 PEPCK_ATP PF01293.15 KOG98408.1 - 8.7e-218 723.4 0.0 1e-217 723.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.1 KOG98408.1 - 0.011 15.6 0.0 0.1 12.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 KOG98408.1 - 0.032 13.7 0.0 0.082 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain KaiC PF06745.8 KOG98408.1 - 0.05 12.7 0.1 0.1 11.7 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.1 KOG98408.1 - 0.084 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain SelA PF03841.8 KOG98408.1 - 0.13 10.9 0.1 0.86 8.2 0.1 1.9 2 0 0 2 2 2 0 L-seryl-tRNA selenium transferase MRFAP1 PF15155.1 KOG98408.1 - 0.14 12.4 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 MORF4 family-associated protein1 UCH PF00443.24 KOG98409.1 - 8.3e-54 182.4 7.9 8.3e-54 182.4 5.5 1.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOG98409.1 - 2.2e-23 83.1 6.5 2.2e-23 83.1 4.5 2.4 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Med6 PF04934.9 KOG98409.1 - 0.025 14.1 2.8 0.79 9.2 0.1 3.0 3 0 0 3 3 3 0 MED6 mediator sub complex component Zip PF02535.17 KOG98409.1 - 0.23 10.4 3.0 0.42 9.5 2.1 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Innate_immun PF12782.2 KOG98409.1 - 0.53 9.4 5.2 0.82 8.8 3.6 1.2 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family SelP_N PF04592.9 KOG98409.1 - 0.66 9.3 13.1 0.13 11.6 4.1 2.5 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Myb_DNA-bind_6 PF13921.1 KOG98410.1 - 1.1e-26 92.6 3.7 9.2e-10 38.4 0.0 3.6 2 1 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 KOG98410.1 - 1.9e-23 82.2 7.5 6.2e-12 45.3 0.1 3.5 3 0 0 3 3 3 3 Myb-like DNA-binding domain Rap1_C PF11626.3 KOG98410.1 - 0.0067 16.2 2.3 1.2 9.0 0.1 2.6 1 1 0 2 2 2 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_5 PF13873.1 KOG98410.1 - 0.028 14.3 0.9 0.9 9.4 0.4 3.1 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain SKG6 PF08693.5 KOG98411.1 - 5.9e-06 25.4 2.2 1.3e-05 24.4 1.5 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Vpu PF00558.14 KOG98411.1 - 0.0037 16.8 0.0 0.012 15.1 0.0 1.9 1 0 0 1 1 1 1 Vpu protein Sir1 PF11603.3 KOG98412.1 - 1.8e-87 289.9 10.4 4.1e-45 153.0 1.6 4.2 4 0 0 4 4 4 3 Regulatory protein Sir1 PA14 PF07691.7 KOG98413.1 - 2.7e-31 108.1 0.1 6.5e-31 106.9 0.0 1.6 1 1 1 2 2 2 1 PA14 domain PA14_2 PF10528.4 KOG98413.1 - 2.9e-14 53.0 1.2 2.9e-14 53.0 0.8 2.0 2 0 0 2 2 2 1 GLEYA domain Acetyltransf_1 PF00583.19 KOG98414.1 - 2.3e-05 24.3 0.0 3.4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 KOG98414.1 - 0.012 15.6 0.0 0.021 14.7 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KOG98414.1 - 0.058 13.5 0.0 0.084 13.0 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Flocculin_t3 PF13928.1 KOG98415.1 - 9e-05 22.5 14.0 9e-05 22.5 9.7 7.4 3 2 2 5 5 5 3 Flocculin type 3 repeat NifT PF06988.6 KOG98415.1 - 0.052 13.0 0.1 9.3 5.8 0.0 2.5 2 0 0 2 2 2 0 NifT/FixU protein adh_short PF00106.20 KOG98416.1 - 7.2e-15 55.2 0.0 8.6e-15 55.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOG98416.1 - 7.1e-08 32.5 0.0 8.7e-08 32.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOG98416.1 - 1.2e-07 31.6 0.0 1.7e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 KOG98416.1 - 0.0023 17.3 0.0 0.0033 16.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DJ-1_PfpI PF01965.19 KOG98417.1 - 4.3e-26 91.1 0.1 9.5e-26 90.0 0.0 1.5 1 1 0 1 1 1 1 DJ-1/PfpI family DJ-1_PfpI_N PF13587.1 KOG98417.1 - 0.00048 19.5 0.1 0.001 18.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of DJ-1_PfpI family PA14 PF07691.7 KOG98418.1 - 3.6e-22 78.5 0.1 8e-22 77.4 0.0 1.5 1 0 0 1 1 1 1 PA14 domain PA14_2 PF10528.4 KOG98418.1 - 1.4e-13 50.8 0.6 1.4e-13 50.8 0.4 2.3 2 0 0 2 2 2 1 GLEYA domain Flocculin PF00624.13 KOG98418.1 - 3.9e-06 26.5 21.3 3.9e-06 26.5 14.8 4.3 3 1 1 4 4 4 1 Flocculin repeat OPT PF03169.10 KOG98419.1 - 9.6e-151 503.2 44.3 1.2e-150 503.0 30.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Pex2_Pex12 PF04757.9 KOG98420.1 - 5.1e-18 65.3 2.3 7.6e-18 64.7 1.6 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.1 KOG98420.1 - 0.2 11.6 12.3 0.32 11.0 7.9 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4525 PF15027.1 KOG98421.1 - 0.0077 15.7 0.2 0.017 14.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4525) Endonuclease_NS PF01223.18 KOG98422.1 - 2.8e-60 203.5 0.0 3.6e-60 203.1 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Sec10 PF07393.6 KOG98424.1 - 1.3e-66 225.2 19.1 1.7e-66 224.9 13.2 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box PF00646.28 KOG98424.1 - 0.033 13.8 0.1 0.22 11.2 0.0 2.4 2 0 0 2 2 2 0 F-box domain Surp PF01805.15 KOG98425.1 - 1.9e-16 59.4 0.2 1.1e-09 37.7 0.0 2.9 3 1 0 3 3 3 2 Surp module PRP21_like_P PF12230.3 KOG98425.1 - 5.3e-10 39.1 3.2 9.1e-10 38.4 2.2 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein CRAL_TRIO_2 PF13716.1 KOG98426.1 - 2e-31 108.8 1.4 5.8e-31 107.4 1.0 1.7 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.22 KOG98426.1 - 4.1e-07 29.7 0.2 1.4e-06 28.0 0.1 1.9 1 0 0 1 1 1 1 RhoGAP domain Aconitase PF00330.15 KOG98427.1 - 2.4e-178 593.3 0.0 5.9e-178 592.1 0.0 1.7 2 1 0 2 2 2 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 KOG98427.1 - 6.3e-43 146.0 0.0 1.1e-42 145.1 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.8 KOG98427.1 - 0.066 11.7 0.0 0.1 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) SPX PF03105.14 KOG98428.1 - 7.1e-44 150.6 8.9 1e-43 150.0 6.2 1.3 1 0 0 1 1 1 1 SPX domain Na_sulph_symp PF00939.14 KOG98428.1 - 1.7e-19 70.1 35.7 2.3e-19 69.6 24.8 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 KOG98428.1 - 6e-19 67.8 37.8 7.9e-15 54.2 16.2 2.1 1 1 1 2 2 2 2 Citrate transporter PBP1_TM PF14812.1 KOG98428.1 - 0.081 13.2 1.0 0.17 12.2 0.7 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UCH PF00443.24 KOG98429.1 - 2.1e-98 328.7 0.0 1.2e-97 326.2 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOG98429.1 - 3e-21 76.1 0.5 1.5e-12 47.5 0.1 2.5 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.7 KOG98429.1 - 0.00079 19.7 0.0 0.0059 16.9 0.0 2.6 2 0 0 2 2 2 1 DUSP domain UBA_e1_C PF09358.5 KOG98429.1 - 0.0096 16.0 0.6 0.16 12.1 0.1 3.2 4 0 0 4 4 4 1 Ubiquitin-activating enzyme e1 C-terminal domain ELO PF01151.13 KOG98430.1 - 1.2e-57 195.0 27.8 1.6e-57 194.7 19.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family AAA_22 PF13401.1 KOG98431.1 - 2.8e-12 46.9 0.0 1.1e-11 45.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 KOG98431.1 - 1.8e-09 37.9 0.0 8.1e-09 35.7 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOG98431.1 - 2.7e-08 34.0 0.0 8.5e-08 32.3 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain Cdc6_C PF09079.6 KOG98431.1 - 5e-05 22.9 0.0 0.00057 19.5 0.0 2.4 2 0 0 2 2 2 1 CDC6, C terminal NACHT PF05729.7 KOG98431.1 - 0.00034 20.3 0.1 0.3 10.7 0.1 2.7 2 0 0 2 2 2 2 NACHT domain KAP_NTPase PF07693.9 KOG98431.1 - 0.00046 19.2 0.1 0.035 13.1 0.1 2.3 1 1 1 2 2 2 1 KAP family P-loop domain AAA_19 PF13245.1 KOG98431.1 - 0.0025 17.5 0.0 0.0059 16.3 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain Arch_ATPase PF01637.13 KOG98431.1 - 0.0035 17.0 0.0 0.021 14.5 0.0 2.0 1 1 0 1 1 1 1 Archaeal ATPase AFG1_ATPase PF03969.11 KOG98431.1 - 0.0048 15.7 0.0 0.11 11.2 0.0 2.1 2 0 0 2 2 2 1 AFG1-like ATPase NB-ARC PF00931.17 KOG98431.1 - 0.0081 15.0 0.2 2.4 6.9 0.0 2.6 3 0 0 3 3 3 2 NB-ARC domain DUF2075 PF09848.4 KOG98431.1 - 0.04 12.9 0.2 0.26 10.2 0.2 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.1 KOG98431.1 - 0.045 13.6 0.0 5.8 6.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.1 KOG98431.1 - 0.065 12.8 1.6 0.23 11.0 1.1 2.0 1 1 0 1 1 1 0 AAA domain TPT PF03151.11 KOG98432.1 - 9.9e-43 145.4 6.5 9.9e-43 145.4 4.5 3.4 4 0 0 4 4 4 1 Triose-phosphate Transporter family UAA PF08449.6 KOG98432.1 - 0.00079 18.4 7.4 0.00079 18.4 5.1 2.7 3 0 0 3 3 3 1 UAA transporter family EamA PF00892.15 KOG98432.1 - 0.0025 17.8 32.4 0.014 15.4 9.5 3.5 2 2 1 3 3 3 2 EamA-like transporter family MLANA PF14991.1 KOG98432.1 - 0.15 12.0 0.7 0.69 9.9 0.0 2.4 2 0 0 2 2 2 0 Protein melan-A Nuc_sug_transp PF04142.10 KOG98432.1 - 1.5 7.8 12.2 0.3 10.1 0.8 3.0 3 0 0 3 3 3 0 Nucleotide-sugar transporter DUF4538 PF15061.1 KOG98433.1 - 0.35 10.2 1.9 0.62 9.4 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4538) Ribosomal_S11 PF00411.14 KOG98434.1 - 5e-40 136.0 1.0 6e-40 135.8 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Ribosomal_S8 PF00410.14 KOG98435.1 - 3.5e-26 91.5 0.1 4.8e-26 91.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Ribosomal_L39 PF00832.15 KOG98436.1 - 6.8e-21 73.4 15.7 8.1e-21 73.2 10.9 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein RAI1 PF08652.6 KOG98436.1 - 0.16 11.7 0.3 0.2 11.4 0.2 1.3 1 1 0 1 1 1 0 RAI1 like PD-(D/E)XK nuclease Pkinase PF00069.20 KOG98437.1 - 1.8e-46 158.4 0.3 7.6e-46 156.3 0.2 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98437.1 - 4.5e-27 94.7 0.1 7.4e-27 94.0 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2457 PF10446.4 KOG98437.1 - 7e-05 21.7 2.0 7e-05 21.7 1.4 3.4 4 0 0 4 4 4 1 Protein of unknown function (DUF2457) Prothymosin PF03247.9 KOG98437.1 - 0.0017 18.5 17.0 0.0017 18.5 11.8 3.6 3 1 1 4 4 4 1 Prothymosin/parathymosin family DUF4611 PF15387.1 KOG98437.1 - 0.0061 16.6 8.8 0.0061 16.6 6.1 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF4611) Kinase-like PF14531.1 KOG98437.1 - 0.0094 14.9 0.0 0.1 11.5 0.0 2.2 2 0 0 2 2 2 1 Kinase-like U1snRNP70_N PF12220.3 KOG98437.1 - 0.2 11.9 10.6 0.5 10.7 3.3 2.7 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Tim54 PF11711.3 KOG98437.1 - 2.7 6.4 12.7 1 7.8 2.8 2.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Mannosyl_trans3 PF11051.3 KOG98438.1 - 1.5e-84 283.5 0.1 2.4e-84 282.8 0.1 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Gon7 PF08738.5 KOG98440.1 - 8.5e-39 131.7 0.1 9.8e-39 131.5 0.1 1.0 1 0 0 1 1 1 1 Gon7 family FlxA PF14282.1 KOG98440.1 - 0.033 14.1 1.5 0.046 13.6 1.0 1.2 1 0 0 1 1 1 0 FlxA-like protein Glyco_transf_34 PF05637.7 KOG98441.1 - 4.9e-66 222.6 0.0 6.4e-66 222.2 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF244 PF03112.9 KOG98441.1 - 0.026 14.0 0.6 0.059 12.9 0.4 1.5 1 0 0 1 1 1 0 Uncharacterized protein family (ORF7) DUF DHFR_1 PF00186.14 KOG98442.1 - 0.076 12.6 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 Dihydrofolate reductase DUF1952 PF09189.5 KOG98442.1 - 0.11 12.2 0.0 1.2 8.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1952) ATP12 PF07542.6 KOG98443.1 - 1.4e-29 102.5 0.0 2.1e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein Prefoldin_2 PF01920.15 KOG98444.1 - 8e-13 48.0 10.0 8.8e-13 47.9 6.9 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF4144 PF13642.1 KOG98444.1 - 0.042 14.1 1.0 0.057 13.7 0.7 1.3 1 0 0 1 1 1 0 protein structure with unknown function CST-I PF06002.7 KOG98444.1 - 0.063 12.5 1.4 0.061 12.5 1.0 1.2 1 0 0 1 1 1 0 Alpha-2,3-sialyltransferase (CST-I) DUF3560 PF12083.3 KOG98444.1 - 0.09 12.8 0.9 1.3 9.1 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3560) DUF948 PF06103.6 KOG98444.1 - 0.19 11.6 4.8 0.75 9.6 0.3 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.7 KOG98444.1 - 2.7 7.7 8.1 50 3.6 5.6 2.0 1 1 0 1 1 1 0 Laminin Domain II ATG27 PF09451.5 KOG98445.1 - 2.7e-74 249.8 1.8 3.1e-74 249.5 1.2 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.13 KOG98445.1 - 0.0058 16.4 2.7 0.068 12.9 0.8 2.2 2 0 0 2 2 2 1 Cation-independent mannose-6-phosphate receptor repeat UPF0233 PF06781.7 KOG98445.1 - 0.011 15.2 0.1 0.03 13.9 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0233) DUF3899 PF13038.1 KOG98445.1 - 0.019 15.0 0.2 0.043 13.9 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3899) ABA_GPCR PF12430.3 KOG98445.1 - 0.062 12.4 0.2 0.53 9.4 0.1 2.3 3 0 0 3 3 3 0 Abscisic acid G-protein coupled receptor Ribosomal_L22 PF00237.14 KOG98446.1 - 3.9e-33 113.5 0.1 3.9e-33 113.5 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e SWIRM PF04433.12 KOG98447.1 - 9.7e-32 108.9 0.1 3e-31 107.3 0.1 1.9 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.26 KOG98447.1 - 4.2e-10 39.5 0.0 9.5e-10 38.3 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOG98447.1 - 8.4e-08 32.2 0.1 3.9e-07 30.0 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain CRAL_TRIO_N PF03765.10 KOG98447.1 - 0.67 10.1 4.5 0.86 9.7 0.0 3.2 3 0 0 3 3 3 0 CRAL/TRIO, N-terminal domain KRE9 PF05390.6 KOG98448.1 - 9.4e-55 183.5 8.5 9.4e-55 183.5 5.9 2.5 2 1 1 3 3 3 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.4 KOG98448.1 - 4.4e-14 52.7 0.8 4.4e-14 52.7 0.5 2.7 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family YtkA PF13115.1 KOG98448.1 - 0.085 13.2 0.3 0.26 11.6 0.0 1.9 2 0 0 2 2 2 0 YtkA-like Rep_fac-A_3 PF08661.6 KOG98449.1 - 1.1e-33 115.3 0.0 1.3e-33 115.1 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Peptidase_M20 PF01546.23 KOG98450.1 - 6.3e-27 94.3 0.0 8.1e-27 93.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 KOG98450.1 - 4.2e-19 68.3 0.0 7e-19 67.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain DUF2401 PF10287.4 KOG98451.1 - 2.4e-93 311.9 3.3 3.2e-93 311.5 2.3 1.1 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.4 KOG98451.1 - 3.4e-25 87.9 0.3 1.3e-24 86.0 0.0 2.2 2 0 0 2 2 2 1 Glycine-rich protein domain (DUF2403) SRI PF08236.6 KOG98453.1 - 9e-26 89.6 7.5 9e-26 89.6 5.2 3.5 2 1 1 3 3 3 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.23 KOG98453.1 - 7.7e-22 78.3 0.2 7.7e-22 78.3 0.1 4.1 3 2 0 3 3 3 1 SET domain WW PF00397.21 KOG98453.1 - 0.015 15.1 0.1 0.029 14.2 0.1 1.4 1 0 0 1 1 1 0 WW domain DUF3677 PF12432.3 KOG98453.1 - 0.089 13.2 4.4 0.34 11.3 1.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3677) polyprenyl_synt PF00348.12 KOG98454.1 - 2.5e-88 295.2 0.1 3e-88 295.0 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase UcrQ PF02939.11 KOG98455.1 - 6.6e-40 134.8 2.9 7.5e-40 134.6 2.0 1.0 1 0 0 1 1 1 1 UcrQ family DUF2741 PF10890.3 KOG98455.1 - 0.074 13.1 0.0 0.097 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2741) Pkinase PF00069.20 KOG98456.1 - 2e-45 155.0 0.0 9.2e-43 146.2 0.0 2.6 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98456.1 - 2.6e-18 66.0 0.0 8.9e-18 64.2 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG98456.1 - 0.0061 15.5 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG98456.1 - 0.071 12.1 0.1 0.16 11.0 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sec23_helical PF04815.10 KOG98456.1 - 0.54 9.7 2.9 19 4.7 0.1 2.4 2 0 0 2 2 2 0 Sec23/Sec24 helical domain Pkinase PF00069.20 KOG98457.1 - 9.6e-71 237.9 0.0 1.2e-70 237.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98457.1 - 8.9e-41 139.6 0.0 1.2e-40 139.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG98457.1 - 7.2e-06 25.1 0.0 1.1e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOG98457.1 - 0.033 13.8 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 KOG98457.1 - 0.055 12.2 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.9 KOG98457.1 - 0.094 11.7 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MFS_1 PF07690.11 KOG98458.1 - 1.5e-21 76.5 32.7 3.8e-20 71.9 12.7 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DnaJ PF00226.26 KOG98459.1 - 1.5e-17 63.0 0.2 4.9e-17 61.4 0.1 2.0 1 0 0 1 1 1 1 DnaJ domain PIR PF00399.14 KOG98461.1 - 9.4e-22 75.5 31.5 2.5e-08 32.9 0.8 4.3 4 0 0 4 4 4 3 Yeast PIR protein repeat DUF973 PF06157.6 KOG98461.1 - 0.16 10.8 2.7 0.26 10.2 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF973) SLD3 PF08639.5 KOG98461.1 - 0.26 9.8 12.2 0.33 9.5 8.5 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 PIR PF00399.14 KOG98462.1 - 1.4e-11 43.2 21.4 1.2e-07 30.7 2.9 3.1 2 0 0 2 2 2 2 Yeast PIR protein repeat Nup153 PF08604.5 KOG98462.1 - 0.019 13.6 8.9 0.023 13.3 6.2 1.0 1 0 0 1 1 1 0 Nucleoporin Nup153-like TPP_enzyme_C PF02775.16 KOG98462.1 - 0.035 13.6 0.3 0.054 13.0 0.2 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain BAP PF06639.6 KOG98462.1 - 0.11 12.1 0.6 0.2 11.3 0.4 1.4 1 0 0 1 1 1 0 Basal layer antifungal peptide (BAP) DUF2217 PF10265.4 KOG98462.1 - 3.3 6.3 5.8 4.3 5.9 4.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Macoilin PF09726.4 KOG98462.1 - 6 5.0 7.8 7.2 4.7 5.4 1.0 1 0 0 1 1 1 0 Transmembrane protein zf-RING_2 PF13639.1 KOG98463.1 - 0.00041 20.1 3.6 0.0012 18.6 2.5 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOG98463.1 - 0.052 13.5 4.7 0.14 12.2 3.3 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOG98463.1 - 0.11 12.5 2.0 0.38 10.8 1.4 2.0 1 0 0 1 1 1 0 RING-H2 zinc finger zf-C3HC4 PF00097.20 KOG98463.1 - 0.47 10.1 5.6 1.3 8.7 3.9 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Peptidase_S64 PF08192.6 KOG98464.1 - 1.6e-271 902.6 0.4 1.8e-271 902.4 0.3 1.0 1 0 0 1 1 1 1 Peptidase family S64 CLAMP PF14769.1 KOG98464.1 - 0.12 12.5 0.2 0.4 10.8 0.1 2.0 2 0 0 2 2 2 0 Flagellar C1a complex subunit C1a-32 6PF2K PF01591.13 KOG98465.1 - 7.9e-89 296.5 0.5 1.1e-88 296.0 0.3 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 KOG98465.1 - 4.1e-33 114.7 0.0 7e-33 113.9 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 KOG98465.1 - 1.3e-05 25.1 0.0 2.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOG98465.1 - 0.00083 20.1 0.1 0.011 16.5 0.0 2.5 2 1 0 2 2 2 1 AAA domain Vps35 PF03635.12 KOG98466.1 - 6.5e-281 933.9 36.1 7.6e-281 933.7 25.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 NAD_binding_5 PF07994.7 KOG98467.1 - 2.9e-117 391.4 0.0 3.4e-117 391.1 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 KOG98467.1 - 6.6e-44 148.3 0.3 1.6e-43 147.0 0.2 1.7 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Pmp3 PF01679.12 KOG98468.1 - 2.5e-18 65.4 2.2 3.1e-18 65.2 1.5 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator F-box-like PF12937.2 KOG98469.1 - 9.1e-10 38.1 0.1 2.7e-09 36.6 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 KOG98469.1 - 9.6e-07 28.3 0.1 3.9e-06 26.3 0.1 2.2 1 0 0 1 1 1 1 F-box domain RNA_polI_A34 PF08208.6 KOG98470.1 - 6e-40 137.0 18.3 9.1e-40 136.4 12.7 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 Peptidase_S49_N PF08496.5 KOG98470.1 - 0.11 12.2 11.2 2 8.1 7.1 2.3 2 1 0 2 2 2 0 Peptidase family S49 N-terminal RNA_pol PF00940.14 KOG98471.1 - 0.0084 14.6 0.4 0.009 14.5 0.2 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase S_tail_recep_bd PF14928.1 KOG98472.1 - 0.14 12.3 0.4 22 5.2 0.0 2.4 2 0 0 2 2 2 0 Short tail fibre protein receptor-binding domain CRAL_TRIO PF00650.15 KOG98473.1 - 6.6e-27 93.9 0.1 2.5e-26 92.0 0.1 1.8 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 KOG98473.1 - 1.9e-13 50.3 0.4 6.7e-13 48.5 0.2 2.0 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Orthopox_A49R PF06489.6 KOG98473.1 - 0.064 13.2 0.1 0.22 11.5 0.0 1.9 2 0 0 2 2 2 0 Orthopoxvirus A49R protein Tim17 PF02466.14 KOG98475.1 - 9.8e-33 112.9 4.3 1.2e-32 112.6 3.0 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Pkinase PF00069.20 KOG98476.1 - 5.9e-52 176.3 0.0 5.9e-52 176.3 0.0 3.2 2 2 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98476.1 - 6.6e-20 71.2 0.0 6.6e-20 71.2 0.0 2.7 2 1 0 2 2 2 1 Protein tyrosine kinase Mem_trans PF03547.13 KOG98476.1 - 0.00018 19.9 3.1 0.00029 19.2 2.2 1.3 1 0 0 1 1 1 1 Membrane transport protein APH PF01636.18 KOG98476.1 - 0.0059 16.3 0.0 0.0059 16.3 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family CAF-1_p150 PF11600.3 KOG98476.1 - 0.013 14.8 48.4 0.031 13.6 33.5 1.6 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Ycf1 PF05758.7 KOG98476.1 - 1.6 6.3 40.0 0.6 7.7 25.2 2.0 2 0 0 2 2 2 0 Ycf1 Asp-B-Hydro_N PF05279.6 KOG98476.1 - 3.1 7.5 28.7 5.4 6.7 19.9 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region RNA_pol_Rpb4 PF03874.11 KOG98477.1 - 1.7e-35 121.5 8.6 1.1e-34 118.9 5.9 2.2 1 1 0 1 1 1 1 RNA polymerase Rpb4 IncFII_repA PF02387.10 KOG98477.1 - 0.028 13.5 8.4 0.014 14.5 4.5 1.5 2 0 0 2 2 2 0 IncFII RepA protein family Cellulose_synt PF03552.9 KOG98477.1 - 0.034 12.4 1.9 0.04 12.2 1.3 1.1 1 0 0 1 1 1 0 Cellulose synthase Rtf2 PF04641.7 KOG98477.1 - 0.057 12.6 6.6 0.075 12.2 4.6 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger RXT2_N PF08595.6 KOG98477.1 - 0.06 13.1 7.3 0.1 12.3 5.1 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF2457 PF10446.4 KOG98477.1 - 0.079 11.6 13.3 0.12 11.1 9.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Tom37_C PF11801.3 KOG98477.1 - 0.44 10.4 8.3 0.052 13.4 2.3 1.8 1 1 1 2 2 2 0 Tom37 C-terminal domain DUF3295 PF11702.3 KOG98477.1 - 1 8.2 8.5 17 4.2 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3295) FLO_LFY PF01698.11 KOG98477.1 - 1.9 7.2 14.2 1.6 7.4 9.0 1.5 1 1 1 2 2 2 0 Floricaula / Leafy protein BTV_NS2 PF04514.7 KOG98477.1 - 4.8 5.9 11.1 6.5 5.5 7.7 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 PBP1_TM PF14812.1 KOG98477.1 - 5 7.4 14.4 3.7 7.9 8.0 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal IFT57 PF10498.4 KOG98477.1 - 5.2 5.7 16.7 0.24 10.0 6.6 2.0 1 1 0 2 2 2 0 Intra-flagellar transport protein 57 Glyco_transf_15 PF01793.11 KOG98478.1 - 3.2e-129 430.6 13.2 3.9e-129 430.3 9.2 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DEAD PF00270.24 KOG98479.1 - 2.4e-42 144.2 0.5 3e-42 143.9 0.3 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOG98479.1 - 6.6e-06 26.0 0.0 1.1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 KOG98479.1 - 0.0004 20.0 0.1 0.00073 19.2 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 KOG98479.1 - 0.026 14.1 0.1 0.065 12.8 0.1 1.6 1 1 0 1 1 1 0 AAA domain DUF1811 PF08838.5 KOG98479.1 - 0.068 13.1 0.0 17 5.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) AAA_11 PF13086.1 KOG98479.1 - 0.093 12.2 0.1 0.51 9.8 0.0 1.9 1 1 1 2 2 2 0 AAA domain PhoH PF02562.11 KOG98479.1 - 0.15 11.2 0.8 0.91 8.7 0.1 2.0 2 0 0 2 2 2 0 PhoH-like protein Glyco_transf_8 PF01501.15 KOG98480.1 - 1.4e-41 142.4 0.1 2e-41 141.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 PAP2 PF01569.16 KOG98481.1 - 1e-13 51.1 2.1 1e-13 51.1 1.5 2.0 2 0 0 2 2 2 1 PAP2 superfamily DUF2638 PF10937.3 KOG98482.1 - 0.14 13.1 1.1 0.45 11.5 0.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2638) Mito_carr PF00153.22 KOG98483.1 - 1.2e-65 217.2 2.3 2.2e-23 81.7 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein mIF3 PF14877.1 KOG98484.1 - 6.9e-66 221.0 9.4 6.9e-66 221.0 6.5 1.5 2 0 0 2 2 2 1 Mitochondrial translation initiation factor IF3_C PF00707.17 KOG98484.1 - 0.00058 19.5 0.5 0.0017 18.0 0.2 2.0 1 1 1 2 2 2 1 Translation initiation factor IF-3, C-terminal domain Rhodanese PF00581.15 KOG98484.1 - 0.04 14.2 0.0 0.1 12.9 0.0 1.7 1 0 0 1 1 1 0 Rhodanese-like domain CPSase_L_D2 PF02786.12 KOG98485.1 - 5.5e-115 381.9 1.0 7.1e-84 280.3 0.1 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.17 KOG98485.1 - 6.9e-47 158.2 0.0 1.8e-46 156.8 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 KOG98485.1 - 1e-44 152.2 0.0 2.2e-44 151.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.16 KOG98485.1 - 1.9e-41 141.0 0.2 6.3e-41 139.3 0.0 2.0 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.14 KOG98485.1 - 6.9e-41 138.8 0.8 2.5e-40 137.0 0.1 2.5 4 0 0 4 4 3 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_L_chain PF00289.17 KOG98485.1 - 1e-40 138.2 0.1 4.1e-20 71.9 0.0 2.9 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain OTCace PF00185.19 KOG98485.1 - 2.8e-35 121.5 0.0 2.8e-34 118.2 0.0 2.6 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ATP-grasp_4 PF13535.1 KOG98485.1 - 3.5e-34 118.1 0.3 4.9e-21 75.2 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.1 KOG98485.1 - 2.4e-24 85.7 0.3 5.8e-14 51.5 0.0 3.4 3 0 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon MGS PF02142.17 KOG98485.1 - 9.9e-22 76.6 0.0 5.9e-21 74.2 0.0 2.5 2 0 0 2 2 1 1 MGS-like domain Dala_Dala_lig_C PF07478.8 KOG98485.1 - 1.6e-16 60.2 3.5 1.6e-09 37.4 0.2 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 KOG98485.1 - 7.4e-15 54.7 0.7 1.4e-06 27.7 0.1 2.5 2 0 0 2 2 2 2 ATP-grasp domain RimK PF08443.6 KOG98485.1 - 1.2e-07 31.3 0.3 1.1e-05 24.9 0.1 2.6 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 KOG98485.1 - 3e-06 27.1 1.6 0.016 15.0 0.1 2.7 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.8 KOG98485.1 - 2.6e-05 23.7 0.0 0.00055 19.4 0.0 2.4 1 1 0 1 1 1 1 Peptidase C26 TrkH PF02386.11 KOG98486.1 - 4.8e-153 508.8 1.0 4.9e-149 495.7 0.0 2.2 2 0 0 2 2 2 2 Cation transport protein Vps54 PF07928.7 KOG98486.1 - 0.068 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Vps54-like protein PCP_red PF08369.5 KOG98486.1 - 0.19 11.6 0.0 0.5 10.2 0.0 1.6 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit Pkinase PF00069.20 KOG98487.1 - 1.4e-54 185.0 0.0 2e-54 184.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98487.1 - 2e-36 125.3 0.0 3e-36 124.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG98487.1 - 9.3e-05 21.5 0.0 0.00015 20.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 KOG98487.1 - 0.0003 19.7 0.2 0.001 17.9 0.1 1.8 2 0 0 2 2 2 1 Seadornavirus VP7 Pox_ser-thr_kin PF05445.6 KOG98487.1 - 0.12 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase TAT_signal PF10518.4 KOG98488.1 - 0.0089 15.9 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence Sec34 PF04136.10 KOG98488.1 - 0.13 11.9 0.0 0.13 11.9 0.0 1.0 1 0 0 1 1 1 0 Sec34-like family zf-H2C2 PF09337.5 KOG98489.1 - 1.9e-21 75.1 4.2 3.5e-21 74.3 2.9 1.5 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Acetyltransf_1 PF00583.19 KOG98489.1 - 0.00013 21.8 0.0 0.00026 20.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family CN_hydrolase PF00795.17 KOG98490.1 - 4.2e-28 97.9 0.0 6.1e-28 97.4 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase GCD14 PF08704.5 KOG98491.1 - 4.1e-81 272.1 0.4 3.3e-80 269.1 0.3 2.1 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit RrnaAD PF00398.15 KOG98491.1 - 2.2e-05 23.6 0.0 4.4e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 KOG98491.1 - 9.1e-05 22.4 0.0 0.00016 21.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOG98491.1 - 0.00047 20.7 0.0 0.0012 19.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Gcd10p PF04189.8 KOG98491.1 - 0.0022 17.2 0.1 0.0097 15.0 0.0 1.9 2 0 0 2 2 2 1 Gcd10p family PCMT PF01135.14 KOG98491.1 - 0.0065 16.0 0.0 0.015 14.8 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 KOG98491.1 - 0.01 15.4 0.0 0.038 13.5 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain DUF3748 PF12566.3 KOG98491.1 - 0.011 15.6 0.1 0.02 14.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3748) LSM PF01423.17 KOG98492.1 - 3e-14 52.3 0.1 4.9e-14 51.6 0.1 1.3 1 0 0 1 1 1 1 LSM domain Alb1 PF09135.6 KOG98493.1 - 6.2e-18 65.4 7.6 6.2e-18 65.4 5.3 1.9 1 1 1 2 2 2 1 Alb1 Ribul_P_3_epim PF00834.14 KOG98494.1 - 1.5e-69 233.1 0.0 2.6e-69 232.3 0.0 1.3 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.14 KOG98494.1 - 0.022 14.3 0.0 0.069 12.6 0.0 1.8 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain OMPdecase PF00215.19 KOG98494.1 - 0.029 13.7 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family PcrB PF01884.12 KOG98494.1 - 0.032 13.4 0.0 0.047 12.9 0.0 1.3 1 0 0 1 1 1 0 PcrB family Glyco_hydro_31 PF01055.21 KOG98494.1 - 0.15 10.8 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 31 Pho86 PF11124.3 KOG98495.1 - 1.9e-100 335.7 0.4 2.2e-100 335.5 0.3 1.0 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 SUN PF03856.8 KOG98496.1 - 1.3e-103 345.6 16.7 1.5e-103 345.4 11.6 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) ASF1_hist_chap PF04729.8 KOG98497.1 - 6.3e-66 220.7 0.1 8.5e-66 220.3 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone Nop14 PF04147.7 KOG98497.1 - 0.0046 14.9 47.3 0.0057 14.6 32.8 1.1 1 0 0 1 1 1 1 Nop14-like family BUD22 PF09073.5 KOG98497.1 - 0.084 11.9 32.5 0.11 11.5 22.5 1.3 1 0 0 1 1 1 0 BUD22 Daxx PF03344.10 KOG98497.1 - 0.8 8.1 44.1 1.4 7.2 30.6 1.4 1 0 0 1 1 1 0 Daxx Family TFIIF_alpha PF05793.7 KOG98497.1 - 3.7 5.8 41.6 4.2 5.6 28.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) rve PF00665.21 KOG98498.1 - 7.2e-18 64.8 0.2 1.6e-17 63.6 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.1 KOG98498.1 - 0.002 17.7 0.1 0.0064 16.0 0.1 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain DUF2360 PF10152.4 KOG98498.1 - 0.023 14.9 2.1 0.31 11.3 0.0 2.6 3 0 0 3 3 3 0 Predicted coiled-coil domain-containing protein (DUF2360) WD40 PF00400.27 KOG98499.1 - 2.2e-40 135.1 9.3 4.3e-11 42.2 0.2 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat Mdv1 PF11542.3 KOG98499.1 - 2.4e-23 81.7 1.0 5.3e-23 80.6 0.7 1.6 1 0 0 1 1 1 1 Mitochondrial division protein 1 Nup160 PF11715.3 KOG98499.1 - 3.7e-08 31.9 12.3 0.0015 16.8 0.2 4.9 2 2 2 4 4 4 4 Nucleoporin Nup120/160 Sigma70_r1_1 PF03979.9 KOG98499.1 - 0.059 13.3 6.6 0.1 12.5 3.2 2.4 2 1 1 3 3 3 0 Sigma-70 factor, region 1.1 DUF2730 PF10805.3 KOG98499.1 - 0.073 12.8 2.3 0.18 11.5 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) V_ATPase_I PF01496.14 KOG98499.1 - 0.53 8.0 3.0 0.79 7.4 2.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IncA PF04156.9 KOG98499.1 - 6.8 6.2 8.6 15 5.0 5.9 1.6 1 1 0 1 1 1 0 IncA protein Cpn60_TCP1 PF00118.19 KOG98500.1 - 3.1e-146 487.8 4.5 3.6e-146 487.6 3.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MtlR PF05068.7 KOG98500.1 - 0.033 13.6 0.2 0.064 12.6 0.1 1.5 1 0 0 1 1 1 0 Mannitol repressor GATA PF00320.22 KOG98501.1 - 8.1e-14 50.6 2.5 1.4e-13 49.8 1.7 1.4 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 KOG98501.1 - 0.015 14.6 0.3 0.029 13.6 0.2 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding Herpes_UL49_1 PF03117.9 KOG98501.1 - 0.099 11.7 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 UL49 family BP28CT PF08146.7 KOG98502.1 - 2.4e-41 141.0 1.7 2.4e-41 141.0 1.2 5.0 5 0 0 5 5 5 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.3 KOG98502.1 - 2.8e-22 78.9 1.6 2.8e-22 78.9 1.1 4.6 5 0 0 5 5 5 1 U3 small nucleolar RNA-associated protein 10 HEAT_2 PF13646.1 KOG98502.1 - 0.00055 20.1 1.7 6.1 7.2 0.0 6.1 5 0 0 5 5 5 1 HEAT repeats HEAT_EZ PF13513.1 KOG98502.1 - 0.019 15.4 8.0 0.87 10.1 0.4 6.0 5 1 1 6 6 6 0 HEAT-like repeat HEAT PF02985.17 KOG98502.1 - 0.086 12.9 6.1 20 5.6 0.0 5.9 6 0 0 6 6 6 0 HEAT repeat DUF1212 PF06738.7 KOG98503.1 - 9.4e-52 175.2 14.3 3.6e-49 166.8 0.4 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF1212) DUF3815 PF12821.2 KOG98503.1 - 6.2e-24 84.3 10.2 6.2e-24 84.3 7.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3815) Peptidase_A8 PF01252.13 KOG98503.1 - 0.0027 17.3 1.6 0.0074 15.9 1.1 1.7 1 0 0 1 1 1 1 Signal peptidase (SPase) II Peptidase_U57 PF05582.7 KOG98503.1 - 0.16 10.8 0.9 0.32 9.9 0.0 1.9 3 0 0 3 3 3 0 YabG peptidase U57 Pneumo_att_G PF05539.6 KOG98503.1 - 2.5 7.3 6.8 4.3 6.5 4.7 1.3 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Pkinase PF00069.20 KOG98504.1 - 1.3e-56 191.6 0.2 3.4e-54 183.7 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98504.1 - 5.3e-28 97.8 0.7 4.2e-26 91.5 0.1 2.8 2 1 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 KOG98504.1 - 1.9e-06 26.9 0.8 3.8e-06 25.9 0.2 1.6 1 1 0 1 1 1 1 Poxvirus serine/threonine protein kinase VIT PF08487.5 KOG98504.1 - 0.029 14.0 0.2 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 Vault protein inter-alpha-trypsin domain Kdo PF06293.9 KOG98504.1 - 0.12 11.4 0.1 0.34 9.9 0.0 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PHD PF00628.24 KOG98505.1 - 4.9e-10 38.9 10.7 1.7e-09 37.2 6.3 2.5 2 0 0 2 2 2 1 PHD-finger SET PF00856.23 KOG98505.1 - 7.5e-07 29.5 0.1 4.1e-06 27.1 0.0 2.2 3 0 0 3 3 3 1 SET domain PHD_2 PF13831.1 KOG98505.1 - 0.00012 21.2 3.2 0.00027 20.1 2.2 1.5 1 0 0 1 1 1 1 PHD-finger AMPKBI PF04739.10 KOG98505.1 - 2.7 7.9 7.6 5.1 7.0 0.2 3.0 2 2 1 3 3 3 0 5'-AMP-activated protein kinase beta subunit, interation domain Pam16 PF03656.8 KOG98506.1 - 9.7e-59 196.7 1.0 1.1e-58 196.5 0.7 1.0 1 0 0 1 1 1 1 Pam16 STb_secrete PF09075.5 KOG98506.1 - 0.066 13.0 0.6 0.21 11.4 0.1 2.0 1 1 1 2 2 2 0 Heat-stable enterotoxin B, secretory Zn_clus PF00172.13 KOG98507.1 - 2.6e-07 30.4 13.4 4.9e-07 29.5 9.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.19 KOG98507.1 - 0.0042 16.8 0.0 0.017 14.9 0.0 2.0 2 0 0 2 2 2 1 PAS fold GTP_EFTU PF00009.22 KOG98508.1 - 4.7e-58 195.7 0.3 2.9e-57 193.1 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 KOG98508.1 - 3.5e-26 90.8 0.1 8.2e-26 89.6 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 KOG98508.1 - 4e-18 65.0 0.0 3.9e-10 39.4 0.0 2.5 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 KOG98508.1 - 2.5e-10 40.3 0.1 9.4e-10 38.4 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KOG98508.1 - 0.0026 17.7 0.0 0.0072 16.2 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GCS PF03074.11 KOG98509.1 - 3.8e-164 546.1 0.2 4.9e-164 545.7 0.2 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase PI3_PI4_kinase PF00454.22 KOG98510.1 - 5.1e-73 245.4 0.1 7.9e-73 244.7 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase ChAPs PF09295.5 KOG98511.1 - 2e-52 178.3 1.2 3.9e-42 144.4 0.3 2.2 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_11 PF13414.1 KOG98511.1 - 1.5e-07 30.9 0.0 1.6e-06 27.6 0.1 2.2 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 KOG98511.1 - 6.4e-05 22.5 0.4 0.1 12.5 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 KOG98511.1 - 0.00016 21.7 0.1 0.00076 19.5 0.1 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 KOG98511.1 - 0.0039 16.7 0.6 0.03 13.9 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOG98511.1 - 0.0089 15.8 0.1 0.059 13.2 0.0 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOG98511.1 - 0.0099 16.5 0.0 0.023 15.3 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOG98511.1 - 0.017 15.0 1.2 0.05 13.5 0.5 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat SAPS PF04499.10 KOG98512.1 - 2.6e-167 557.2 10.1 2.6e-167 557.2 7.0 3.0 3 0 0 3 3 3 1 SIT4 phosphatase-associated protein PTPLA PF04387.9 KOG98513.1 - 2.4e-47 160.4 10.2 3.7e-47 159.8 7.1 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Pigment_DH PF06324.6 KOG98513.1 - 0.016 14.4 0.4 0.034 13.4 0.3 1.6 1 0 0 1 1 1 0 Pigment-dispersing hormone (PDH) Ribosomal_L21p PF00829.16 KOG98514.1 - 5.3e-05 23.2 0.0 7.1e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Pkinase PF00069.20 KOG98515.1 - 2.1e-66 223.7 0.0 5.9e-66 222.2 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98515.1 - 1.8e-45 155.0 0.0 3.5e-45 154.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG98515.1 - 5.4e-11 41.9 0.0 1.5e-07 30.6 0.0 3.0 3 0 0 3 3 3 2 Kinase-like APH PF01636.18 KOG98515.1 - 0.52 9.9 0.0 0.84 9.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Na_H_Exchanger PF00999.16 KOG98516.1 - 1.5e-63 214.6 38.4 2.1e-63 214.1 26.6 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF241 PF03087.9 KOG98516.1 - 0.044 13.2 1.7 0.081 12.4 1.1 1.3 1 0 0 1 1 1 0 Arabidopsis protein of unknown function S1FA PF04689.8 KOG98516.1 - 2.1 8.2 4.8 8 6.4 0.1 3.3 3 0 0 3 3 3 0 DNA binding protein S1FA SPC12 PF06645.8 KOG98516.1 - 3.3 7.5 7.6 9 6.1 0.1 3.9 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Ion_trans_2 PF07885.11 KOG98517.1 - 6.6e-27 93.0 24.4 4.7e-18 64.6 5.0 3.3 4 0 0 4 4 4 2 Ion channel DUF21 PF01595.15 KOG98517.1 - 0.91 8.7 7.5 1 8.6 1.0 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF21 UvrD_C PF13361.1 KOG98518.1 - 1.6e-88 297.5 3.0 1.6e-88 297.5 2.1 2.9 3 0 0 3 3 3 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 KOG98518.1 - 9.3e-71 238.6 0.1 9.3e-71 238.6 0.1 2.9 3 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.1 KOG98518.1 - 5.2e-12 45.3 0.0 1.5e-11 43.8 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain UvrD_C_2 PF13538.1 KOG98518.1 - 6.3e-10 39.1 0.0 1.9e-06 27.9 0.0 3.2 3 0 0 3 3 3 2 UvrD-like helicase C-terminal domain AAA_30 PF13604.1 KOG98518.1 - 0.00013 21.5 1.1 0.00036 20.1 0.1 2.0 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.9 KOG98518.1 - 0.0021 17.7 0.0 0.0084 15.7 0.0 2.1 2 0 0 2 2 2 1 Helicase GWT1 PF06423.7 KOG98519.1 - 1.2e-44 151.6 2.1 1.2e-44 151.6 1.4 2.7 4 0 0 4 4 4 1 GWT1 BRCT PF00533.21 KOG98520.1 - 1.5e-25 89.1 8.5 3.7e-10 39.8 0.1 4.6 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 KOG98520.1 - 2.7e-08 33.5 0.2 3.7e-05 23.5 0.0 4.4 5 0 0 5 5 5 1 twin BRCT domain Rhamno_transf PF11316.3 KOG98520.1 - 0.095 11.8 0.8 0.34 10.0 0.0 2.0 2 0 0 2 2 2 0 Putative rhamnosyl transferase Zn_clus PF00172.13 KOG98521.1 - 8.5e-11 41.5 10.8 1.3e-10 40.9 7.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain OTCace PF00185.19 KOG98522.1 - 4.5e-41 140.3 0.1 1e-40 139.2 0.0 1.6 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.16 KOG98522.1 - 5.7e-40 136.2 0.1 9.4e-40 135.5 0.1 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain RNA_lig_T4_1 PF09511.5 KOG98523.1 - 1.4e-78 263.3 0.1 3.5e-78 262.1 0.0 1.7 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.6 KOG98523.1 - 8.7e-76 253.4 0.8 8.7e-76 253.4 0.6 2.4 3 0 0 3 3 3 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.6 KOG98523.1 - 7.1e-60 202.3 2.6 1.1e-59 201.7 1.8 1.3 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain ABC_tran PF00005.22 KOG98523.1 - 0.049 13.9 0.1 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.1 KOG98523.1 - 0.4 10.8 2.1 2.9 8.0 0.9 2.5 2 1 0 2 2 2 0 AAA domain Exo70 PF03081.10 KOG98524.1 - 6.1e-86 288.5 10.1 6.1e-86 288.5 7.0 2.1 2 1 0 2 2 2 1 Exo70 exocyst complex subunit PilJ PF13675.1 KOG98524.1 - 0.048 13.9 0.4 17 5.7 0.1 3.7 3 1 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Cytochrom_B562 PF07361.6 KOG98524.1 - 6.5 7.2 8.2 7.9 6.9 0.1 3.8 4 0 0 4 4 4 0 Cytochrome b562 EF-hand_4 PF12763.2 KOG98525.1 - 0.00094 18.8 0.1 0.0022 17.7 0.1 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand DUF3808 PF10300.4 KOG98526.1 - 2.9e-159 530.5 0.2 3.5e-159 530.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_16 PF13432.1 KOG98526.1 - 0.16 12.7 8.9 5.3 7.8 0.0 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat Actin PF00022.14 KOG98527.1 - 6.2e-98 327.8 0.0 5.7e-97 324.6 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 KOG98527.1 - 0.029 12.9 0.0 2.2 6.7 0.0 2.2 2 0 0 2 2 2 0 MreB/Mbl protein KH_1 PF00013.24 KOG98528.1 - 1.1e-79 262.0 40.0 1.1e-12 47.3 0.4 12.8 13 1 0 13 13 13 8 KH domain KH_3 PF13014.1 KOG98528.1 - 1.5e-52 174.5 27.2 4.3e-09 35.8 0.1 10.9 11 0 0 11 11 11 7 KH domain KH_2 PF07650.12 KOG98528.1 - 2.5e-13 49.3 19.2 0.001 18.5 0.0 7.2 5 2 0 6 6 6 4 KH domain KH_4 PF13083.1 KOG98528.1 - 1.5e-07 30.9 10.2 0.26 10.9 0.0 7.3 6 1 1 7 7 7 3 KH domain SLS PF14611.1 KOG98528.1 - 7.8e-06 25.4 17.3 0.31 10.4 0.0 7.4 5 3 4 9 9 9 4 Mitochondrial inner-membrane-bound regulator TBP PF00352.16 KOG98528.1 - 0.05 12.9 0.5 14 5.1 0.0 3.6 3 0 0 3 3 3 0 Transcription factor TFIID (or TATA-binding protein, TBP) EMP24_GP25L PF01105.19 KOG98528.1 - 0.1 12.2 3.2 0.65 9.6 0.3 3.3 1 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DegQ PF08181.6 KOG98528.1 - 1 9.1 4.9 0.49 10.1 0.0 2.9 3 0 0 3 3 3 0 DegQ (SacQ) family CAP PF00188.21 KOG98529.1 - 5.7e-22 78.5 1.4 5.7e-22 78.5 1.0 2.1 2 1 0 2 2 2 1 Cysteine-rich secretory protein family DUF3306 PF11748.3 KOG98529.1 - 0.0069 17.0 6.0 0.01 16.4 3.8 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3306) PAP1 PF08601.5 KOG98529.1 - 0.018 14.7 6.8 0.019 14.6 4.7 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 DUF2611 PF11022.3 KOG98529.1 - 5.7 7.1 8.1 8.6e+02 0.1 5.6 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2611) Macoilin PF09726.4 KOG98529.1 - 10 4.2 11.2 12 4.0 7.7 1.1 1 0 0 1 1 1 0 Transmembrane protein CAP PF00188.21 KOG98530.1 - 1.2e-20 74.2 3.7 1.2e-20 74.2 2.5 4.6 4 2 0 4 4 4 1 Cysteine-rich secretory protein family Cytokin_check_N PF10407.4 KOG98531.1 - 4.1e-31 106.4 2.7 9e-31 105.3 1.9 1.6 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus SMC_N PF02463.14 KOG98532.1 - 3.2e-51 173.6 63.6 2e-50 171.0 44.1 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 KOG98532.1 - 9.4e-29 99.8 0.6 3.8e-28 97.8 0.0 2.5 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 KOG98532.1 - 9.7e-14 52.0 6.3 1.9e-09 37.9 1.8 5.5 2 1 3 5 5 5 2 AAA domain AAA_23 PF13476.1 KOG98532.1 - 2.1e-10 41.2 33.9 2.1e-10 41.2 23.5 7.8 2 1 2 5 5 5 1 AAA domain AAA_29 PF13555.1 KOG98532.1 - 0.00052 19.4 0.0 0.0013 18.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain BLOC1_2 PF10046.4 KOG98532.1 - 0.0053 16.8 4.1 0.0053 16.8 2.8 9.8 7 2 2 10 10 10 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 DnaJ PF00226.26 KOG98533.1 - 1.7e-22 78.9 3.8 3.8e-22 77.8 2.7 1.7 1 0 0 1 1 1 1 DnaJ domain DUF3819 PF12842.2 KOG98533.1 - 0.014 15.0 0.1 0.05 13.2 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) Sld5 PF05916.6 KOG98534.1 - 5.6e-17 61.9 1.1 9.8e-17 61.2 0.8 1.4 1 0 0 1 1 1 1 GINS complex protein DUF790 PF05626.6 KOG98534.1 - 0.03 12.8 0.0 0.039 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF790) DUF619 PF04768.8 KOG98535.1 - 5.4e-52 175.6 0.7 1.7e-51 174.0 0.1 2.0 3 0 0 3 3 3 1 Protein of unknown function (DUF619) A_deaminase PF00962.17 KOG98536.1 - 4.5e-18 65.2 0.0 1.9e-12 46.7 0.0 3.6 3 1 0 3 3 3 3 Adenosine/AMP deaminase WD40 PF00400.27 KOG98537.1 - 3.2e-17 61.6 0.4 3.5e-06 26.6 0.0 5.2 6 0 0 6 6 6 3 WD domain, G-beta repeat Apc4_WD40 PF12894.2 KOG98537.1 - 0.0031 16.9 0.0 0.078 12.5 0.0 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Esterase PF00756.15 KOG98538.1 - 1.6e-70 237.3 0.3 1.8e-70 237.2 0.2 1.0 1 0 0 1 1 1 1 Putative esterase Abhydrolase_5 PF12695.2 KOG98538.1 - 1.4e-06 28.1 0.0 1.9e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOG98538.1 - 0.014 14.5 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family DLH PF01738.13 KOG98538.1 - 0.022 14.0 0.1 0.62 9.3 0.1 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_6 PF12697.2 KOG98538.1 - 0.029 14.2 0.0 0.049 13.4 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 KOG98538.1 - 0.037 12.9 0.0 0.059 12.2 0.0 1.3 1 1 0 1 1 1 0 Chlorophyllase enzyme Esterase_phd PF10503.4 KOG98538.1 - 0.076 12.2 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase CBFD_NFYB_HMF PF00808.18 KOG98540.1 - 0.00011 22.1 0.0 0.00028 20.8 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF4411 PF14367.1 KOG98540.1 - 0.0054 16.4 0.0 0.0091 15.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4411) Histone PF00125.19 KOG98540.1 - 0.15 12.1 0.0 0.55 10.4 0.0 1.7 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Ribosomal_L17 PF01196.14 KOG98541.1 - 2.4e-28 98.5 0.1 7.4e-28 96.9 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L17 EcoEI_R_C PF08463.5 KOG98541.1 - 0.0086 15.9 0.6 0.61 9.9 0.1 2.2 2 0 0 2 2 2 2 EcoEI R protein C-terminal Phosphodiest PF01663.17 KOG98543.1 - 8.6e-13 48.3 3.1 2.1e-09 37.2 0.2 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 KOG98543.1 - 3.6e-05 23.0 0.0 7.8e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 KOG98543.1 - 0.0073 15.7 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily LepA_C PF06421.7 KOG98544.1 - 0.0075 16.1 3.4 0.019 14.8 2.4 1.7 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus Aminotran_1_2 PF00155.16 KOG98545.1 - 2.1e-90 303.3 0.0 2.5e-90 303.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 KOG98545.1 - 5.8e-08 32.1 0.0 9.2e-08 31.5 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 KOG98545.1 - 0.00014 20.3 0.1 0.00047 18.5 0.1 1.7 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 KOG98545.1 - 0.0041 15.9 0.1 0.02 13.6 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 KOG98545.1 - 0.014 14.5 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_3 PF00202.16 KOG98545.1 - 0.03 13.1 0.0 0.053 12.3 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-III DUF2240 PF09999.4 KOG98545.1 - 0.065 12.6 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2240) CLN3 PF02487.12 KOG98546.1 - 3.2e-182 605.8 22.0 3.2e-181 602.5 15.2 1.9 1 1 0 1 1 1 1 CLN3 protein MFS_1 PF07690.11 KOG98546.1 - 1.2e-05 24.1 20.7 9.3e-05 21.2 14.3 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily HbrB PF08539.6 KOG98547.1 - 1e-41 142.3 0.3 1.8e-41 141.6 0.2 1.4 1 0 0 1 1 1 1 HbrB-like Pkinase PF00069.20 KOG98548.1 - 3.4e-34 118.1 0.0 8.5e-34 116.8 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98548.1 - 1.8e-17 63.2 0.0 1.2e-16 60.5 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase zf-C2H2 PF00096.21 KOG98549.1 - 5.5e-19 67.2 80.6 5.1e-06 26.5 0.8 10.6 11 0 0 11 11 11 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KOG98549.1 - 1.7e-17 62.7 74.3 6.7e-09 35.6 0.2 9.1 10 0 0 10 10 10 4 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOG98549.1 - 4.3e-05 23.5 70.2 0.0018 18.4 0.3 9.5 10 0 0 10 10 10 5 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KOG98549.1 - 0.00027 20.7 53.1 0.003 17.3 1.4 7.6 7 1 1 8 8 8 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOG98549.1 - 0.0018 18.3 52.6 0.014 15.5 2.1 7.9 6 1 1 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KOG98549.1 - 0.12 12.5 46.7 0.19 12.0 2.3 7.9 8 0 0 8 8 8 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.1 KOG98549.1 - 0.15 11.7 15.3 0.2 11.3 0.1 5.2 5 0 0 5 5 5 0 zinc-finger of a C2HC-type Phage_Orf51 PF06194.6 KOG98549.1 - 4.2 7.5 9.9 11 6.2 0.0 3.4 3 0 0 3 3 3 0 Phage Conserved Open Reading Frame 51 Lysine_decarbox PF03641.9 KOG98550.1 - 1.4e-47 160.8 0.2 1.8e-47 160.4 0.1 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase Tim54 PF11711.3 KOG98551.1 - 2.8e-138 460.6 0.0 3.2e-138 460.4 0.0 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Vps26 PF03643.10 KOG98552.1 - 3.5e-123 409.7 0.0 4.1e-123 409.5 0.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 KOG98552.1 - 2.6e-05 24.1 0.2 0.0001 22.1 0.1 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 KOG98552.1 - 0.00049 20.2 0.0 0.0087 16.1 0.0 2.4 1 1 1 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Gp_dh_C PF02800.15 KOG98553.1 - 1.4e-73 245.5 0.1 1.9e-73 245.1 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 KOG98553.1 - 5.4e-59 198.4 0.0 8.9e-59 197.7 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 KOG98553.1 - 0.0018 18.2 0.3 0.0057 16.5 0.1 2.1 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus rRNA_proc-arch PF13234.1 KOG98555.1 - 4.5e-95 317.8 0.8 4.5e-95 317.8 0.5 1.6 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.7 KOG98555.1 - 3.9e-63 211.9 0.4 8.1e-63 210.9 0.3 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 KOG98555.1 - 5.8e-22 77.9 0.0 1.4e-20 73.5 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG98555.1 - 2.8e-06 27.0 0.0 6.8e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain T2SE PF00437.15 KOG98555.1 - 0.072 11.9 0.0 0.2 10.5 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein Snf7 PF03357.16 KOG98556.1 - 7.9e-11 41.6 12.8 1.6e-10 40.6 8.9 1.5 1 0 0 1 1 1 1 Snf7 GTPase_Cys_C PF12631.2 KOG98556.1 - 0.015 15.7 1.1 0.035 14.5 0.1 2.1 2 0 0 2 2 2 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE RFC1 PF08519.7 KOG98556.1 - 0.047 13.4 0.8 0.13 12.0 0.6 1.8 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain Val_tRNA-synt_C PF10458.4 KOG98556.1 - 0.19 11.8 5.7 0.2 11.7 0.1 3.4 3 0 0 3 3 3 0 Valyl tRNA synthetase tRNA binding arm UBX PF00789.15 KOG98557.1 - 1.7e-20 72.8 0.0 4.1e-20 71.6 0.0 1.7 1 0 0 1 1 1 1 UBX domain Cullin PF00888.17 KOG98558.1 - 2.5e-10 39.5 15.7 3.4e-10 39.1 8.1 2.8 2 1 0 2 2 2 1 Cullin family BPL_LplA_LipB PF03099.14 KOG98559.1 - 2.3e-19 69.6 0.1 4.4e-19 68.7 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family TEX12 PF15219.1 KOG98559.1 - 0.093 12.7 0.2 8.9 6.3 0.0 2.5 1 1 1 2 2 2 0 Testis-expressed 12 FAD_binding_2 PF00890.19 KOG98560.1 - 1.5e-122 409.4 3.3 1.9e-122 409.1 2.3 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 KOG98560.1 - 2.4e-49 166.4 0.7 3.8e-49 165.8 0.5 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.9 KOG98560.1 - 3.6e-08 33.5 0.4 5.7e-05 23.0 0.0 3.0 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 KOG98560.1 - 4.4e-06 25.8 3.5 0.00064 18.6 0.2 2.7 3 0 0 3 3 3 2 Glucose inhibited division protein A Thi4 PF01946.12 KOG98560.1 - 7.6e-06 25.1 0.1 0.002 17.2 0.0 2.8 3 0 0 3 3 3 2 Thi4 family DAO PF01266.19 KOG98560.1 - 8.6e-05 21.5 0.8 0.001 18.0 0.6 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 KOG98560.1 - 0.0049 15.9 0.1 0.011 14.8 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 KOG98560.1 - 0.0079 14.7 0.2 0.049 12.1 0.0 2.3 3 0 0 3 3 3 1 HI0933-like protein RabGAP-TBC PF00566.13 KOG98561.1 - 5e-21 75.1 6.4 8.3e-21 74.4 3.4 2.0 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Pas_Saposin PF09016.5 KOG98561.1 - 0.27 11.2 3.9 0.23 11.5 0.6 2.2 2 0 0 2 2 2 0 Pas factor saposin fold LRR_6 PF13516.1 KOG98563.1 - 0.13 12.4 4.8 48 4.4 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich repeat Nsp1_C PF05064.8 KOG98564.1 - 1.2e-11 44.3 2.1 1.2e-11 44.3 1.5 2.3 1 1 1 2 2 2 1 Nsp1-like C-terminal region KIP1 PF07765.7 KOG98564.1 - 0.00025 20.8 0.6 0.0033 17.2 0.1 2.2 1 1 1 2 2 2 1 KIP1-like protein WXG100 PF06013.7 KOG98564.1 - 0.0033 17.3 3.9 0.0033 17.3 2.7 1.9 2 1 0 2 2 1 1 Proteins of 100 residues with WXG GldM_N PF12081.3 KOG98564.1 - 0.0095 15.4 6.3 0.012 15.2 4.3 1.2 1 0 0 1 1 1 1 GldM N-terminal domain STAT_alpha PF01017.15 KOG98564.1 - 0.016 14.9 5.5 0.024 14.3 3.8 1.2 1 0 0 1 1 1 0 STAT protein, all-alpha domain CENP-F_leu_zip PF10473.4 KOG98564.1 - 0.018 14.8 7.2 0.052 13.4 5.0 1.7 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.7 KOG98564.1 - 0.024 14.4 15.5 0.042 13.6 10.6 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4200 PF13863.1 KOG98564.1 - 0.033 14.1 5.5 0.038 13.9 2.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Muted PF14942.1 KOG98564.1 - 0.033 14.0 4.4 0.049 13.5 2.7 1.6 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein V-SNARE PF05008.10 KOG98564.1 - 0.069 13.3 7.6 1.1 9.5 0.3 2.8 1 1 2 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF948 PF06103.6 KOG98564.1 - 0.091 12.6 6.6 1.9 8.4 0.9 2.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Spc24 PF08286.6 KOG98564.1 - 0.17 11.5 13.8 0.059 13.0 4.5 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Prefoldin_2 PF01920.15 KOG98564.1 - 0.23 11.2 8.0 1.8 8.3 3.7 2.8 2 1 0 2 2 2 0 Prefoldin subunit Cep57_MT_bd PF06657.8 KOG98564.1 - 0.26 11.2 3.1 8.1 6.4 0.1 3.0 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Laminin_II PF06009.7 KOG98564.1 - 0.28 10.9 13.7 0.26 11.0 6.3 2.0 1 1 1 2 2 2 0 Laminin Domain II DUF342 PF03961.8 KOG98564.1 - 0.35 9.2 6.0 0.39 9.0 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Peptidase_S64 PF08192.6 KOG98564.1 - 0.36 9.0 8.2 0.37 9.0 5.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 APG6 PF04111.7 KOG98564.1 - 0.37 9.8 10.0 0.47 9.4 7.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 OmpH PF03938.9 KOG98564.1 - 0.4 10.6 7.3 0.5 10.2 5.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Hep_59 PF07052.6 KOG98564.1 - 0.46 10.8 4.6 0.8 10.1 3.1 1.6 1 1 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 FlaG PF03646.10 KOG98564.1 - 0.57 10.3 10.2 0.096 12.8 2.8 2.1 1 1 1 2 2 2 0 FlaG protein CDC37_N PF03234.9 KOG98564.1 - 0.63 10.3 7.4 0.8 9.9 5.2 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding DUF2935 PF11155.3 KOG98564.1 - 0.66 10.0 5.6 2.1 8.4 3.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) RP-C_C PF11800.3 KOG98564.1 - 0.85 9.2 6.7 0.92 9.1 0.6 2.0 1 1 1 2 2 2 0 Replication protein C C-terminal region Tropomyosin_1 PF12718.2 KOG98564.1 - 1.2 8.9 10.5 2.4 7.9 6.3 2.0 1 1 1 2 2 2 0 Tropomyosin like NPV_P10 PF05531.7 KOG98564.1 - 1.3 9.3 10.4 0.67 10.2 1.7 3.0 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein AATF-Che1 PF13339.1 KOG98564.1 - 1.5 9.0 6.5 1.3 9.2 2.6 1.8 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor RNA_polI_A14 PF08203.6 KOG98564.1 - 1.5 9.0 5.1 1.6 9.0 2.2 2.1 1 1 1 2 2 2 0 Yeast RNA polymerase I subunit RPA14 KAR PF15222.1 KOG98564.1 - 2.7 8.1 10.1 0.33 11.0 0.6 2.4 1 1 1 2 2 2 0 Kidney androgen-regulated Med4 PF10018.4 KOG98564.1 - 2.8 7.3 9.5 0.26 10.6 1.7 2.3 1 1 2 3 3 3 0 Vitamin-D-receptor interacting Mediator subunit 4 EAP30 PF04157.11 KOG98564.1 - 3 6.9 10.1 0.24 10.5 1.5 2.1 2 0 0 2 2 2 0 EAP30/Vps36 family Reo_sigmaC PF04582.7 KOG98564.1 - 4.1 6.4 10.8 13 4.8 6.6 1.6 1 1 0 1 1 1 0 Reovirus sigma C capsid protein Syntaxin-6_N PF09177.6 KOG98564.1 - 4.5 7.7 11.7 5.1 7.5 2.7 2.6 1 1 2 3 3 3 0 Syntaxin 6, N-terminal FliD_N PF02465.13 KOG98564.1 - 4.7 7.6 15.8 11 6.4 5.7 2.9 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 N-terminus XhlA PF10779.4 KOG98564.1 - 8.3 6.4 12.3 43 4.1 4.8 3.1 1 1 1 2 2 2 0 Haemolysin XhlA IncA PF04156.9 KOG98564.1 - 9 5.8 9.3 19 4.7 6.5 1.6 1 1 0 1 1 1 0 IncA protein DUF3414 PF11894.3 KOG98565.1 - 0 1567.7 46.7 0 1567.5 32.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3414) DUF1344 PF07076.6 KOG98565.1 - 0.0036 16.8 0.0 0.012 15.1 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1344) PNK3P PF08645.6 KOG98566.1 - 0.047 13.1 1.1 0.088 12.2 0.3 1.7 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase Translin PF01997.11 KOG98566.1 - 0.29 10.7 6.0 0.06 12.9 1.6 1.7 2 1 0 2 2 2 0 Translin family DUF948 PF06103.6 KOG98567.1 - 0.17 11.7 9.5 0.92 9.4 0.8 2.9 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) ETRAMP PF09716.5 KOG98567.1 - 1.5 8.7 11.4 2 8.4 0.2 3.0 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) YMF19 PF02326.10 KOG98567.1 - 5.4 7.6 5.8 18 5.9 0.4 2.7 1 1 2 3 3 3 0 Plant ATP synthase F0 PX PF00787.19 KOG98568.1 - 1.7e-23 82.5 0.8 4.3e-23 81.2 0.1 2.1 2 0 0 2 2 2 1 PX domain Vps5 PF09325.5 KOG98568.1 - 3.5e-07 29.7 15.8 2.4e-05 23.7 2.1 2.2 2 0 0 2 2 2 2 Vps5 C terminal like Baculo_PEP_C PF04513.7 KOG98568.1 - 0.0054 16.5 4.2 0.1 12.4 0.3 2.3 1 1 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus ING PF12998.2 KOG98568.1 - 0.0073 16.5 2.5 0.0073 16.5 1.7 2.9 1 1 2 3 3 3 1 Inhibitor of growth proteins N-terminal histone-binding Nup54 PF13874.1 KOG98568.1 - 0.02 14.5 4.3 0.22 11.2 0.5 3.0 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 NPV_P10 PF05531.7 KOG98568.1 - 0.058 13.6 6.0 22 5.3 2.5 3.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Allexi_40kDa PF05549.6 KOG98568.1 - 0.07 12.4 4.7 0.24 10.6 0.9 2.3 2 0 0 2 2 2 0 Allexivirus 40kDa protein Reo_sigmaC PF04582.7 KOG98568.1 - 0.096 11.8 1.8 0.51 9.4 0.2 2.4 1 1 2 3 3 3 0 Reovirus sigma C capsid protein FlaC_arch PF05377.6 KOG98568.1 - 0.32 10.9 6.7 3.1 7.7 0.1 3.4 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) TMP_2 PF06791.8 KOG98568.1 - 0.4 10.2 1.4 0.55 9.8 0.3 1.7 2 0 0 2 2 2 0 Prophage tail length tape measure protein DUF4618 PF15397.1 KOG98568.1 - 0.49 9.6 19.6 0.2 10.9 8.9 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF4618) DUF745 PF05335.8 KOG98568.1 - 0.75 9.2 4.0 7.3 6.0 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF745) GreA_GreB_N PF03449.10 KOG98568.1 - 0.95 9.5 7.4 8.2 6.5 0.3 4.5 5 0 0 5 5 5 0 Transcription elongation factor, N-terminal RPW8 PF05659.6 KOG98568.1 - 1.5 8.3 10.1 2.3 7.7 4.6 2.8 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF3552 PF12072.3 KOG98568.1 - 1.5 7.9 13.9 0.16 11.1 3.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Laminin_II PF06009.7 KOG98568.1 - 2 8.1 7.6 1.5 8.5 1.2 2.7 2 1 1 3 3 3 0 Laminin Domain II DUF1664 PF07889.7 KOG98568.1 - 2 8.2 10.3 4.9 6.9 2.8 3.0 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Cep57_CLD_2 PF14197.1 KOG98568.1 - 2.1 8.3 7.5 2.7 7.9 1.8 2.9 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 IncA PF04156.9 KOG98568.1 - 2.7 7.5 16.5 1.6 8.2 5.3 2.7 2 1 0 2 2 2 0 IncA protein DASH_Dam1 PF08653.5 KOG98568.1 - 3.1 7.6 5.8 4.9 6.9 0.1 4.0 4 1 2 6 6 4 0 DASH complex subunit Dam1 DUF948 PF06103.6 KOG98568.1 - 5.4 6.9 9.7 0.55 10.1 2.0 2.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) dCMP_cyt_deam_1 PF00383.17 KOG98569.1 - 5.3e-21 74.1 0.1 7.5e-21 73.6 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.1 KOG98569.1 - 0.0007 19.4 0.3 0.062 13.1 0.2 2.3 1 1 0 1 1 1 1 Bd3614-like deaminase MafB19-deam PF14437.1 KOG98569.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 MafB19-like deaminase APOBEC_N PF08210.6 KOG98569.1 - 0.12 11.9 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 APOBEC-like N-terminal domain HSP70 PF00012.15 KOG98570.1 - 8.9e-265 879.2 12.7 1e-264 879.0 8.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOG98570.1 - 1.1e-18 66.8 1.3 3.2e-17 62.1 0.2 2.1 2 0 0 2 2 2 2 MreB/Mbl protein Hydantoinase_A PF01968.13 KOG98570.1 - 0.0017 17.5 3.3 0.048 12.7 0.0 3.1 2 1 1 3 3 3 1 Hydantoinase/oxoprolinase BcrAD_BadFG PF01869.15 KOG98570.1 - 0.0054 16.0 0.1 0.023 14.0 0.1 2.0 1 1 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family FtsA PF14450.1 KOG98570.1 - 0.085 12.7 7.3 0.42 10.4 0.9 3.4 2 2 0 2 2 2 0 Cell division protein FtsA FGGY_C PF02782.11 KOG98570.1 - 0.11 12.1 0.0 0.28 10.7 0.0 1.7 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain DEAD PF00270.24 KOG98571.1 - 2.1e-45 154.2 0.2 7.8e-45 152.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF4217 PF13959.1 KOG98571.1 - 3.6e-25 87.2 0.1 7.6e-25 86.2 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 KOG98571.1 - 1.6e-22 79.1 0.2 4.4e-22 77.7 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOG98571.1 - 0.00021 21.1 0.0 0.00021 21.1 0.0 3.2 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit PPTA PF01239.17 KOG98572.1 - 2.2e-32 109.0 14.8 7.8e-09 34.5 0.0 4.7 4 0 0 4 4 4 4 Protein prenyltransferase alpha subunit repeat DUF4219 PF13961.1 KOG98572.1 - 0.18 11.3 2.4 5.6 6.5 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) HORMA PF02301.13 KOG98573.1 - 1.3e-45 155.4 0.2 1.4e-45 155.3 0.1 1.0 1 0 0 1 1 1 1 HORMA domain ATG13 PF10033.4 KOG98573.1 - 0.011 15.1 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 13 DUF1649 PF07855.7 KOG98573.1 - 0.024 14.3 0.1 0.08 12.6 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1649) DUF4279 PF14106.1 KOG98573.1 - 0.04 13.7 0.1 0.33 10.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4279) V-set_CD47 PF08204.6 KOG98573.1 - 0.1 12.3 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain RBD-FIP PF09457.5 KOG98573.1 - 0.12 12.1 0.6 0.29 10.9 0.4 1.7 1 0 0 1 1 1 0 FIP domain Vps53_N PF04100.7 KOG98574.1 - 8.4e-111 370.4 13.7 1.4e-110 369.7 9.5 1.4 1 0 0 1 1 1 1 Vps53-like, N-terminal LRV_FeS PF05484.6 KOG98575.1 - 0.25 10.9 3.3 0.39 10.3 0.7 2.4 1 1 1 2 2 2 0 LRV protein FeS4 cluster Ribonuc_red_sm PF00268.16 KOG98576.1 - 2.1e-119 397.6 2.2 3.2e-119 397.1 1.5 1.3 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF3595 PF12166.3 KOG98576.1 - 0.042 12.6 5.8 1 8.0 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3595) RE_XcyI PF09571.5 KOG98576.1 - 0.17 10.7 1.8 7 5.4 0.0 2.2 2 0 0 2 2 2 0 XcyI restriction endonuclease RRN7 PF11781.3 KOG98577.1 - 9.7e-10 37.7 0.2 2.3e-09 36.5 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase I-specific transcription initiation factor Rrn7 Cullin_Nedd8 PF10557.4 KOG98577.1 - 0.015 15.0 0.4 0.045 13.5 0.1 1.9 2 0 0 2 2 2 0 Cullin protein neddylation domain Clat_adaptor_s PF01217.15 KOG98578.1 - 1.4e-39 135.0 3.6 1.8e-39 134.7 2.5 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SH3_1 PF00018.23 KOG98580.1 - 2e-08 33.4 0.3 5.7e-08 32.0 0.2 1.9 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 KOG98580.1 - 1.2e-06 27.9 0.0 2.8e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 KOG98580.1 - 1.8e-05 24.1 0.2 5.2e-05 22.7 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain Sad1_UNC PF07738.8 KOG98581.1 - 4.5e-06 26.4 1.2 0.00029 20.6 0.1 2.9 2 1 0 2 2 2 1 Sad1 / UNC-like C-terminal IncA PF04156.9 KOG98581.1 - 0.00095 18.8 0.1 0.00095 18.8 0.1 2.2 2 0 0 2 2 2 1 IncA protein Phasin PF05597.6 KOG98581.1 - 0.19 11.4 3.6 0.14 11.9 0.5 2.1 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Baculo_PEP_C PF04513.7 KOG98581.1 - 0.21 11.4 7.6 0.037 13.8 2.4 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1539 PF07560.6 KOG98581.1 - 0.29 11.0 10.9 0.027 14.3 2.2 2.6 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1539) Cpn60_TCP1 PF00118.19 KOG98583.1 - 3.3e-154 514.1 2.2 3.8e-154 513.9 1.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mad3_BUB1_I PF08311.7 KOG98584.1 - 1.7e-43 147.3 0.5 3.3e-43 146.4 0.4 1.5 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.6 KOG98584.1 - 2.7e-25 88.0 0.7 7.7e-25 86.5 0.5 1.8 1 0 0 1 1 1 1 Mad3/BUB1 homology region 2 VTC PF09359.5 KOG98585.1 - 8e-104 346.6 0.2 8e-104 346.6 0.1 1.5 2 0 0 2 2 2 1 VTC domain SPX PF03105.14 KOG98585.1 - 1.7e-21 77.2 11.7 4.1e-10 39.9 0.2 3.6 1 1 1 2 2 2 2 SPX domain DUF202 PF02656.10 KOG98585.1 - 3e-06 27.3 7.4 6.4e-06 26.2 4.5 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF202) RNA_pol_Rpb4 PF03874.11 KOG98586.1 - 1.9e-30 105.2 1.4 2.4e-30 104.9 0.9 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 PUF PF00806.14 KOG98587.1 - 2.4e-33 111.6 12.3 0.00024 20.4 0.0 9.0 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat DUF778 PF05608.7 KOG98587.1 - 0.19 11.6 1.0 1.4 8.8 0.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF778) Cpn60_TCP1 PF00118.19 KOG98588.1 - 6.2e-139 463.7 6.3 7.1e-139 463.5 4.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cyclin_N PF00134.18 KOG98589.1 - 3.4e-10 39.5 3.2 6.2e-10 38.7 2.2 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.14 KOG98589.1 - 0.061 13.1 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Transcription factor TFIIB repeat PP2C PF00481.16 KOG98590.1 - 1.1e-58 198.5 0.1 2.5e-58 197.4 0.1 1.6 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.2 KOG98590.1 - 5.5e-42 140.7 81.2 1.5e-08 34.0 0.6 12.4 7 2 5 13 13 13 12 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOG98590.1 - 8.9e-35 118.2 71.7 5.6e-09 35.6 3.9 9.8 5 3 5 10 10 10 9 Leucine rich repeat Guanylate_cyc PF00211.15 KOG98590.1 - 7.2e-28 97.1 0.0 1.3e-27 96.3 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_1 PF00560.28 KOG98590.1 - 8.1e-14 49.5 71.0 1.2 9.4 0.2 18.5 16 3 2 18 18 17 6 Leucine Rich Repeat RA PF00788.18 KOG98590.1 - 2e-09 37.7 0.0 4.7e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Ad_cyc_g-alpha PF08509.6 KOG98590.1 - 1.4e-08 33.8 0.1 4e-08 32.4 0.1 1.8 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_7 PF13504.1 KOG98590.1 - 0.00028 20.6 56.8 4.1 8.0 0.1 16.3 17 1 1 18 18 16 2 Leucine rich repeat PP2C_2 PF13672.1 KOG98590.1 - 0.014 14.7 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein phosphatase 2C LRR_6 PF13516.1 KOG98590.1 - 0.19 11.8 73.6 1.8 8.9 0.1 16.6 18 1 1 19 19 18 0 Leucine Rich repeat LRR_9 PF14580.1 KOG98590.1 - 0.25 10.9 13.0 0.22 11.0 1.3 4.0 2 1 3 5 5 5 0 Leucine-rich repeat DUF2065 PF09838.4 KOG98590.1 - 0.63 9.7 0.0 1.4 8.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2065) SYS1 PF09801.4 KOG98591.1 - 2e-49 167.2 12.2 2.4e-49 167.0 8.4 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network COX16 PF14138.1 KOG98592.1 - 1.1e-30 105.6 0.1 1.8e-30 104.9 0.1 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 Ribophorin_I PF04597.9 KOG98593.1 - 2.8e-133 444.5 8.5 3.2e-133 444.4 5.9 1.0 1 0 0 1 1 1 1 Ribophorin I Aa_trans PF01490.13 KOG98594.1 - 4.1e-88 295.6 21.1 4.9e-88 295.3 14.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Mpp10 PF04006.7 KOG98595.1 - 1.1e-151 506.2 53.2 1.4e-151 505.8 36.9 1.1 1 0 0 1 1 1 1 Mpp10 protein Candida_ALS_N PF11766.3 KOG98597.1 - 9.9e-78 260.4 7.7 1.3e-77 260.0 5.3 1.1 1 0 0 1 1 1 1 Cell-wall agglutinin N-terminal ligand-sugar binding SprB PF13573.1 KOG98597.1 - 0.0004 19.9 0.8 0.0004 19.9 0.6 3.2 3 0 0 3 3 3 1 SprB repeat Flocculin PF00624.13 KOG98597.1 - 0.001 18.8 23.7 0.001 18.8 16.4 2.7 4 0 0 4 4 4 1 Flocculin repeat Adaptin_N PF01602.15 KOG98598.1 - 2.2e-112 376.0 17.7 2.7e-112 375.7 12.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 KOG98598.1 - 1.1e-05 25.5 0.3 0.31 11.3 0.0 3.6 3 1 0 3 3 3 2 HEAT repeats FANCI_S2 PF14676.1 KOG98598.1 - 0.28 11.0 8.3 0.027 14.3 0.7 3.0 4 0 0 4 4 4 0 FANCI solenoid 2 DUF2562 PF10814.3 KOG98599.1 - 0.22 11.4 4.1 0.26 11.2 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2562) Peptidase_M29 PF02073.10 KOG98599.1 - 0.23 10.1 2.5 0.26 9.9 1.7 1.0 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) PV-1 PF06637.6 KOG98599.1 - 1.5 7.3 10.7 1.6 7.1 7.4 1.0 1 0 0 1 1 1 0 PV-1 protein (PLVAP) CAF-1_p150 PF11600.3 KOG98599.1 - 3.5 6.9 19.7 4 6.7 13.7 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal LEA_1 PF03760.10 KOG98599.1 - 4.4 7.5 14.9 16 5.7 10.4 2.0 1 1 0 1 1 1 0 Late embryogenesis abundant (LEA) group 1 DDRGK PF09756.4 KOG98599.1 - 6.4 6.1 16.7 7.7 5.8 11.6 1.1 1 0 0 1 1 1 0 DDRGK domain TBCA PF02970.11 KOG98599.1 - 8.6 6.5 14.8 0.66 10.0 2.2 2.1 1 1 1 2 2 2 0 Tubulin binding cofactor A DNA_pol_E_B PF04042.11 KOG98600.1 - 3.1e-54 183.4 0.1 4.2e-54 182.9 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DUF4238 PF14022.1 KOG98600.1 - 0.015 14.6 0.2 0.041 13.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4238) PDZ_assoc PF10600.4 KOG98600.1 - 0.091 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 PDZ-associated domain of NMDA receptors EIF_2_alpha PF07541.7 KOG98601.1 - 2.1e-40 136.9 1.1 3.7e-40 136.2 0.1 1.8 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 KOG98601.1 - 4.6e-14 52.2 0.6 1.2e-13 50.9 0.4 1.7 1 0 0 1 1 1 1 S1 RNA binding domain EXOSC1 PF10447.4 KOG98601.1 - 0.083 12.8 0.2 0.23 11.4 0.2 1.8 1 1 0 1 1 1 0 Exosome component EXOSC1/CSL4 Med9 PF07544.8 KOG98601.1 - 0.14 11.9 1.8 1 9.1 0.3 2.9 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Memo PF01875.12 KOG98602.1 - 3.9e-107 357.2 0.3 4.5e-107 357.0 0.2 1.0 1 0 0 1 1 1 1 Memo-like protein CbiX PF01903.12 KOG98602.1 - 0.079 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 CbiX Gp_dh_C PF02800.15 KOG98603.1 - 3.4e-74 247.5 0.1 5.2e-74 246.9 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 KOG98603.1 - 1.2e-59 200.6 0.7 7e-59 198.1 0.1 2.0 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 KOG98603.1 - 0.01 15.7 1.7 0.015 15.2 0.3 2.1 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.14 KOG98603.1 - 0.073 12.2 0.1 0.23 10.5 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ATP-sulfurylase PF01747.12 KOG98604.1 - 3.1e-88 294.6 0.0 4.1e-88 294.2 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.1 KOG98604.1 - 8.4e-50 168.3 0.0 1.3e-49 167.6 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain SPC12 PF06645.8 KOG98605.1 - 2.4e-24 84.9 1.2 2.9e-24 84.6 0.8 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) Involucrin_N PF10583.4 KOG98607.1 - 0.01 16.1 2.0 0.015 15.5 1.4 1.3 1 0 0 1 1 1 0 Involucrin of squamous epithelia N-terminus Mannosyl_trans PF05007.8 KOG98608.1 - 1.8e-101 339.1 17.8 1.8e-101 339.1 12.4 1.9 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.8 KOG98608.1 - 5.7e-16 58.3 8.3 5.7e-16 58.3 5.7 1.6 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U DUF2029 PF09594.5 KOG98608.1 - 3.3e-11 43.1 2.7 3.3e-11 43.1 1.9 1.7 2 1 0 2 2 2 1 Protein of unknown function (DUF2029) PMT_2 PF13231.1 KOG98608.1 - 7e-05 22.7 9.4 7e-05 22.7 6.5 3.0 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase SUI1 PF01253.17 KOG98609.1 - 2.8e-20 71.9 2.3 2.8e-20 71.9 1.6 1.7 2 0 0 2 2 2 1 Translation initiation factor SUI1 DUF3271 PF11675.3 KOG98609.1 - 0.0053 15.9 0.9 0.0071 15.5 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3271) PIN_2 PF10130.4 KOG98609.1 - 1.1 9.3 6.0 0.7 9.9 0.1 2.3 1 1 1 2 2 2 0 PIN domain GAGA_bind PF06217.7 KOG98609.1 - 1.5 8.6 5.0 1 9.2 2.4 1.5 1 1 0 1 1 1 0 GAGA binding protein-like family ILVD_EDD PF00920.16 KOG98610.1 - 2.6e-204 679.4 0.2 3e-204 679.2 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family Rotamase PF00639.16 KOG98611.1 - 2.9e-27 95.2 0.0 4e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 KOG98611.1 - 9.4e-22 77.4 0.0 1.3e-21 77.0 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 KOG98611.1 - 7.1e-09 36.3 0.0 1.3e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.21 KOG98611.1 - 2.2e-07 30.5 2.6 3.6e-07 29.9 1.8 1.4 1 0 0 1 1 1 1 WW domain Acyl_CoA_thio PF02551.10 KOG98612.1 - 1.9e-55 186.0 3.6 2.9e-40 136.9 0.7 3.1 2 1 0 2 2 2 2 Acyl-CoA thioesterase 4HBT_3 PF13622.1 KOG98612.1 - 6.1e-24 85.1 0.0 8e-24 84.7 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily LSM PF01423.17 KOG98613.1 - 1.4e-11 43.7 0.2 2.3e-11 43.0 0.1 1.3 1 0 0 1 1 1 1 LSM domain Aldolase_II PF00596.16 KOG98614.1 - 4.6e-41 140.4 0.0 5.4e-41 140.2 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain RLAN PF14401.1 KOG98614.1 - 0.14 11.6 0.0 0.83 9.1 0.0 2.1 1 1 0 1 1 1 0 RimK-like ATPgrasp N-terminal domain 3-HAO PF06052.7 KOG98615.1 - 7.3e-73 242.9 0.1 8.6e-73 242.7 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.6 KOG98615.1 - 5.5e-05 22.5 0.0 9.8e-05 21.7 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Nudix_N_2 PF14803.1 KOG98615.1 - 0.03 14.0 0.7 4.7 6.9 0.2 2.6 2 0 0 2 2 2 0 Nudix N-terminal DUF2296 PF10058.4 KOG98615.1 - 0.03 14.0 1.7 0.57 9.9 0.1 2.3 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) Cupin_1 PF00190.17 KOG98615.1 - 0.032 13.6 0.0 0.047 13.1 0.0 1.2 1 0 0 1 1 1 0 Cupin DZR PF12773.2 KOG98615.1 - 0.11 12.3 0.8 0.44 10.3 0.5 2.0 1 1 0 1 1 1 0 Double zinc ribbon Sec7 PF01369.15 KOG98617.1 - 3.2e-61 206.3 5.8 7.6e-61 205.1 0.1 3.2 3 1 1 4 4 4 2 Sec7 domain Pro_isomerase PF00160.16 KOG98618.1 - 4.2e-39 134.2 0.1 7e-39 133.5 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 KOG98618.1 - 7.9e-14 51.0 4.9 8.5e-07 28.5 0.9 2.4 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOG98618.1 - 1.5e-10 40.1 10.5 5e-06 26.0 0.3 3.9 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOG98618.1 - 1e-09 37.5 7.5 2.8e-07 29.8 0.5 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOG98618.1 - 8.9e-08 31.9 1.9 1.2e-05 25.1 0.6 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOG98618.1 - 2e-05 24.0 11.9 0.0017 18.0 0.5 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOG98618.1 - 0.0001 22.8 0.5 0.00025 21.6 0.2 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOG98618.1 - 0.0099 16.0 2.0 0.9 9.8 0.1 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat DUF3856 PF12968.2 KOG98618.1 - 0.025 14.4 0.1 0.056 13.2 0.1 1.6 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) TPR_6 PF13174.1 KOG98618.1 - 0.036 14.5 0.2 0.036 14.5 0.2 3.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOG98618.1 - 0.047 13.5 0.1 0.79 9.6 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.13 KOG98618.1 - 0.17 11.7 3.2 0.48 10.3 0.2 2.7 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Apc3 PF12895.2 KOG98618.1 - 0.23 11.6 8.2 5.2 7.2 5.2 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Rav1p_C PF12234.3 KOG98619.1 - 6.5e-273 906.6 3.9 9.3e-273 906.1 1.2 2.0 2 0 0 2 2 2 1 RAVE protein 1 C terminal WD40 PF00400.27 KOG98619.1 - 8.3e-10 38.1 4.9 0.021 14.7 0.0 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat Pet191_N PF10203.4 KOG98620.1 - 5.9e-26 90.3 2.8 8.6e-26 89.7 2.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 KOG98620.1 - 0.006 16.3 0.8 3.8 7.3 0.0 2.5 2 0 0 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.8 KOG98620.1 - 0.032 14.1 1.0 0.65 9.9 0.2 2.5 2 0 0 2 2 2 0 CHCH domain SNF2_N PF00176.18 KOG98621.1 - 2.4e-80 269.5 0.3 4.6e-80 268.6 0.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOG98621.1 - 7.5e-15 54.5 0.0 3.5e-14 52.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HECT PF00632.20 KOG98622.1 - 1.1e-81 274.4 4.3 2.3e-81 273.4 3.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Voltage_CLC PF00654.15 KOG98624.1 - 3.1e-79 266.5 23.6 3.1e-79 266.5 16.4 1.7 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 KOG98624.1 - 2.3e-13 49.6 0.0 1.2e-05 25.0 0.0 2.7 2 0 0 2 2 2 2 CBS domain Urb2 PF10441.4 KOG98625.1 - 1.7e-64 217.4 2.0 1.7e-64 217.4 1.4 2.6 3 0 0 3 3 3 1 Urb2/Npa2 family Nucleopor_Nup85 PF07575.8 KOG98626.1 - 8.6e-175 582.1 1.3 1e-174 581.9 0.9 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin CDC27 PF09507.5 KOG98627.1 - 8.6e-06 25.2 34.0 8.6e-06 25.2 23.6 1.6 2 0 0 2 2 2 1 DNA polymerase subunit Cdc27 Vps55 PF04133.9 KOG98628.1 - 1.1e-44 150.9 6.5 1.4e-44 150.7 4.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF2085 PF09858.4 KOG98628.1 - 0.0024 17.8 0.2 0.0024 17.8 0.1 1.5 2 0 0 2 2 2 1 Predicted membrane protein (DUF2085) 5TM-5TMR_LYT PF07694.7 KOG98628.1 - 0.014 14.7 2.4 0.029 13.6 1.7 1.6 1 1 0 1 1 1 0 5TMR of 5TMR-LYT DUF2108 PF09881.4 KOG98628.1 - 0.36 10.6 2.9 1.2 8.9 0.1 2.4 2 1 0 2 2 2 0 Predicted membrane protein (DUF2108) DUF998 PF06197.8 KOG98628.1 - 0.44 9.8 5.1 0.38 10.0 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF998) HSP70 PF00012.15 KOG98629.1 - 1.2e-267 888.8 14.2 1.3e-267 888.6 9.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOG98629.1 - 2.6e-14 52.5 3.0 3.1e-12 45.7 0.7 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 KOG98629.1 - 0.002 17.7 0.1 0.0062 16.1 0.0 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DUF2797 PF10977.3 KOG98629.1 - 0.036 13.6 3.7 0.068 12.7 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) DUF615 PF04751.9 KOG98629.1 - 0.068 12.8 4.6 0.16 11.6 3.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF615) Hydantoinase_A PF01968.13 KOG98629.1 - 0.12 11.4 9.0 0.2 10.7 0.1 3.4 4 0 0 4 4 4 0 Hydantoinase/oxoprolinase Gp-FAR-1 PF05823.7 KOG98629.1 - 0.22 11.4 7.4 0.47 10.4 5.1 1.5 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) BSMAP PF12280.3 KOG98630.1 - 0.33 10.8 2.7 0.37 10.6 1.0 1.7 2 0 0 2 2 2 0 Brain specific membrane anchored protein eIF-5a PF01287.15 KOG98631.1 - 8.2e-28 96.1 0.8 1.3e-27 95.5 0.5 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold KOW PF00467.24 KOG98631.1 - 7.1e-05 22.3 0.8 0.00013 21.4 0.6 1.5 1 0 0 1 1 1 1 KOW motif EFP_N PF08207.7 KOG98631.1 - 0.00077 19.2 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain TcdB_toxin_midN PF12256.3 KOG98631.1 - 0.15 11.5 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Insecticide toxin TcdB middle/N-terminal region Cytochrom_C PF00034.16 KOG98632.1 - 2e-10 41.3 0.1 3.2e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 KOG98632.1 - 3e-08 33.7 2.0 6.5e-07 29.4 1.4 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.1 KOG98632.1 - 0.014 14.8 0.6 0.057 12.8 0.1 2.0 2 0 0 2 2 2 0 Cytochrome c-550 domain Cytochrom_C1 PF02167.10 KOG98632.1 - 0.077 12.6 0.1 0.1 12.2 0.1 1.4 1 1 0 1 1 1 0 Cytochrome C1 family NAD_kinase PF01513.16 KOG98633.1 - 8.8e-82 274.0 0.0 1.2e-81 273.5 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.19 KOG98633.1 - 0.033 13.6 0.0 0.44 9.9 0.0 2.6 3 0 0 3 3 3 0 Diacylglycerol kinase catalytic domain Isy1 PF06246.7 KOG98634.1 - 5.2e-43 147.3 19.1 4.8e-42 144.1 13.3 1.9 1 1 0 1 1 1 1 Isy1-like splicing family DUF1672 PF07901.6 KOG98634.1 - 0.22 10.4 6.8 0.015 14.3 1.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1672) Calci_bind_CcbP PF11535.3 KOG98634.1 - 0.88 9.8 5.7 8.4 6.6 0.8 3.0 3 0 0 3 3 3 0 Calcium binding FAD_binding_2 PF00890.19 KOG98635.1 - 4.6e-71 239.8 0.0 5.2e-71 239.6 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 KOG98635.1 - 5.5e-08 32.9 0.6 0.00066 19.6 0.0 3.8 2 2 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KOG98635.1 - 1.2e-06 28.4 0.1 5.5e-06 26.3 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 KOG98635.1 - 1.5e-05 24.2 0.8 0.02 13.9 0.0 2.5 2 0 0 2 2 2 2 Thi4 family DAO PF01266.19 KOG98635.1 - 0.00019 20.4 0.0 0.0072 15.2 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.9 KOG98635.1 - 0.00056 18.5 4.5 0.23 9.8 0.0 3.1 3 1 0 3 3 3 2 HI0933-like protein Pyr_redox_3 PF13738.1 KOG98635.1 - 0.00084 19.4 0.0 0.0068 16.4 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOG98635.1 - 0.0026 16.7 0.0 0.31 9.9 0.0 2.6 3 0 0 3 3 3 1 Lycopene cyclase protein FAD_binding_3 PF01494.14 KOG98635.1 - 0.022 13.8 0.0 0.37 9.7 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.1 KOG98635.1 - 0.03 14.0 0.0 0.38 10.5 0.0 2.4 1 1 0 1 1 1 0 FAD-NAD(P)-binding GMC_oxred_N PF00732.14 KOG98635.1 - 0.061 12.4 0.2 1.8 7.6 0.0 2.6 3 0 0 3 3 3 0 GMC oxidoreductase zf-HIT PF04438.11 KOG98639.1 - 6.5e-12 44.8 13.3 1.2e-11 44.0 9.2 1.4 1 0 0 1 1 1 1 HIT zinc finger CDC14 PF08045.6 KOG98639.1 - 0.0021 17.2 0.3 0.0027 16.8 0.2 1.1 1 0 0 1 1 1 1 Cell division control protein 14, SIN component Sec7 PF01369.15 KOG98639.1 - 0.0056 16.3 0.3 0.0072 16.0 0.2 1.2 1 0 0 1 1 1 1 Sec7 domain zf-MYND PF01753.13 KOG98639.1 - 0.03 14.2 10.3 0.047 13.5 7.2 1.3 1 0 0 1 1 1 0 MYND finger YL1_C PF08265.6 KOG98639.1 - 0.039 13.5 0.0 0.13 11.8 0.0 1.8 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain Lipin_N PF04571.9 KOG98639.1 - 0.079 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 lipin, N-terminal conserved region zf-Mss51 PF13824.1 KOG98639.1 - 0.15 11.9 5.0 1.3 8.9 4.3 1.9 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 GFO_IDH_MocA_C PF02894.12 KOG98640.1 - 0.00013 21.7 0.0 0.00058 19.6 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain GFO_IDH_MocA PF01408.17 KOG98640.1 - 0.00029 21.3 0.0 0.00044 20.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DUF4588 PF15251.1 KOG98641.1 - 3.8e-11 43.4 5.9 5.1e-11 43.0 4.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4588) Peptidase_S46 PF10459.4 KOG98641.1 - 0.03 12.7 3.0 0.04 12.3 2.1 1.1 1 0 0 1 1 1 0 Peptidase S46 Thymidylate_kin PF02223.12 KOG98642.1 - 1.2e-47 161.7 0.0 1.3e-47 161.5 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.1 KOG98642.1 - 0.0027 17.9 0.2 0.015 15.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 KOG98642.1 - 0.02 14.8 0.1 0.041 13.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain Clat_adaptor_s PF01217.15 KOG98643.1 - 1.3e-56 190.2 1.9 1.5e-56 190.1 1.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Pkinase PF00069.20 KOG98644.1 - 4.7e-40 137.3 0.0 7.9e-40 136.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98644.1 - 6.5e-14 51.6 0.0 1.2e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOG98644.1 - 0.0048 15.9 0.0 0.0085 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOG98644.1 - 0.027 13.4 0.0 0.046 12.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like HLH PF00010.21 KOG98645.1 - 6.6e-12 44.9 2.5 6.6e-12 44.9 1.8 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain FANCI_S2 PF14676.1 KOG98645.1 - 0.087 12.7 0.3 0.14 12.0 0.2 1.2 1 0 0 1 1 1 0 FANCI solenoid 2 LicD PF04991.8 KOG98646.1 - 6.6e-52 176.5 4.8 6.6e-52 176.5 3.4 2.8 3 1 0 3 3 3 1 LicD family CN_hydrolase PF00795.17 KOG98647.1 - 1.3e-13 50.7 0.0 1.8e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase TFIIS_C PF01096.13 KOG98648.1 - 1.2e-17 63.2 1.6 1.2e-17 63.2 1.1 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 KOG98648.1 - 3.3e-16 58.6 9.6 4.2e-14 51.9 0.5 3.0 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit Lar_restr_allev PF14354.1 KOG98648.1 - 4.8e-05 23.5 5.1 0.0023 18.1 0.2 2.6 2 1 1 3 3 3 1 Restriction alleviation protein Lar DZR PF12773.2 KOG98648.1 - 0.00078 19.2 7.3 0.38 10.6 0.1 3.0 2 1 0 2 2 2 2 Double zinc ribbon zinc_ribbon_2 PF13240.1 KOG98648.1 - 0.002 17.5 15.1 0.096 12.1 0.5 4.1 3 2 1 4 4 4 1 zinc-ribbon domain TF_Zn_Ribbon PF08271.7 KOG98648.1 - 0.0043 16.3 6.7 0.042 13.1 2.1 2.8 2 1 0 2 2 2 1 TFIIB zinc-binding zf-ribbon_3 PF13248.1 KOG98648.1 - 0.0061 15.7 10.3 1.1 8.5 0.2 4.2 4 0 0 4 4 4 1 zinc-ribbon domain Terminase_GpA PF05876.7 KOG98648.1 - 0.013 13.8 1.6 0.017 13.5 0.4 1.6 1 1 1 2 2 2 0 Phage terminase large subunit (GpA) zf-H2C2_2 PF13465.1 KOG98648.1 - 0.017 15.3 3.9 0.37 11.1 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger double domain RRN7 PF11781.3 KOG98648.1 - 0.017 14.5 5.7 4.3 6.9 0.3 3.5 3 0 0 3 3 3 0 RNA polymerase I-specific transcription initiation factor Rrn7 Zn_Tnp_IS1595 PF12760.2 KOG98648.1 - 0.02 14.6 0.3 0.02 14.6 0.2 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain C1_1 PF00130.17 KOG98648.1 - 0.025 14.3 1.9 2.8 7.7 0.1 2.6 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_4 PF13717.1 KOG98648.1 - 0.025 14.2 7.6 5.9 6.6 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Stc1 PF12898.2 KOG98648.1 - 0.027 14.5 4.6 0.081 12.9 0.1 2.2 1 1 1 2 2 2 0 Stc1 domain zinc_ribbon_5 PF13719.1 KOG98648.1 - 0.032 13.8 7.9 5.8 6.5 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain DUF2072 PF09845.4 KOG98648.1 - 0.035 14.0 6.3 0.062 13.2 0.1 3.1 1 1 0 3 3 3 0 Zn-ribbon containing protein (DUF2072) DUF2387 PF09526.5 KOG98648.1 - 0.042 13.7 0.2 0.042 13.7 0.1 2.6 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) Rubredoxin PF00301.15 KOG98648.1 - 0.048 13.5 5.2 9.9 6.1 0.2 3.3 3 0 0 3 3 3 0 Rubredoxin zf-DNA_Pol PF08996.5 KOG98648.1 - 0.053 12.8 5.8 0.12 11.7 0.9 2.2 2 0 0 2 2 2 0 DNA Polymerase alpha zinc finger Mu-like_Com PF10122.4 KOG98648.1 - 0.1 11.6 0.4 5.2 6.2 0.0 2.5 2 0 0 2 2 2 0 Mu-like prophage protein Com Nop10p PF04135.7 KOG98648.1 - 0.11 12.2 1.3 0.2 11.4 0.2 2.0 2 0 0 2 2 1 0 Nucleolar RNA-binding protein, Nop10p family Ribosomal_L32p PF01783.18 KOG98648.1 - 0.13 12.4 2.4 18 5.6 0.1 3.2 3 0 0 3 3 3 0 Ribosomal L32p protein family Prok-RING_1 PF14446.1 KOG98648.1 - 0.21 11.3 8.0 3.9 7.2 0.6 3.4 3 1 0 3 3 3 0 Prokaryotic RING finger family 1 Ogr_Delta PF04606.7 KOG98648.1 - 0.26 10.9 7.6 0.064 12.9 1.9 2.4 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Baculo_LEF5_C PF11792.3 KOG98648.1 - 0.29 10.5 6.4 0.074 12.4 0.7 2.7 2 1 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain zinc-ribbons_6 PF07191.7 KOG98648.1 - 0.35 10.6 7.6 1.4 8.8 0.2 2.7 2 1 0 2 2 2 0 zinc-ribbons Elf1 PF05129.8 KOG98648.1 - 0.38 10.4 5.4 0.28 10.9 0.8 2.3 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like zf-RING_5 PF14634.1 KOG98648.1 - 0.42 10.3 6.6 3.1 7.6 0.5 3.0 3 0 0 3 3 3 0 zinc-RING finger domain zf-TFIIB PF13453.1 KOG98648.1 - 0.47 9.6 5.2 0.18 11.0 0.6 2.2 2 0 0 2 2 2 0 Transcription factor zinc-finger zf-MYND PF01753.13 KOG98648.1 - 0.55 10.1 4.3 8.3 6.3 0.3 2.5 2 1 0 2 2 2 0 MYND finger zf-C4_Topoisom PF01396.14 KOG98648.1 - 0.55 9.7 8.4 0.18 11.3 2.1 2.8 2 1 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger OrfB_Zn_ribbon PF07282.6 KOG98648.1 - 0.55 9.9 7.1 6.4 6.5 1.5 2.7 2 1 0 2 2 2 0 Putative transposase DNA-binding domain zinc_ribbon_6 PF14599.1 KOG98648.1 - 0.58 9.9 3.5 2.3 8.0 0.1 2.8 3 0 0 3 3 2 0 Zinc-ribbon Zn-ribbon_8 PF09723.5 KOG98648.1 - 0.67 9.9 13.0 3.3 7.7 0.1 3.7 3 1 0 3 3 3 0 Zinc ribbon domain CpXC PF14353.1 KOG98648.1 - 0.69 9.8 7.8 1.1 9.2 0.1 2.9 1 1 1 3 3 3 0 CpXC protein Nudix_N_2 PF14803.1 KOG98648.1 - 0.74 9.5 10.9 36 4.1 0.0 4.0 3 1 0 3 3 3 0 Nudix N-terminal HypA PF01155.14 KOG98648.1 - 0.83 9.3 7.9 1.3e+02 2.3 0.1 3.0 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Ribosomal_S27e PF01667.12 KOG98648.1 - 1.5 8.3 9.5 24 4.5 0.0 3.8 3 1 0 3 3 3 0 Ribosomal protein S27 zf-CHY PF05495.7 KOG98648.1 - 1.6 8.9 7.1 4.7 7.4 0.1 2.7 2 1 1 3 3 3 0 CHY zinc finger zf-C3HC4_4 PF15227.1 KOG98648.1 - 1.7 8.6 5.1 5.6 6.9 0.3 3.1 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 KOG98648.1 - 2.7 7.7 7.7 5.4 6.7 0.1 2.9 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-AN1 PF01428.11 KOG98648.1 - 2.9 7.8 9.4 34 4.4 0.1 3.4 3 1 0 3 3 3 0 AN1-like Zinc finger GATA PF00320.22 KOG98648.1 - 3.3 7.1 9.2 0.52 9.6 1.2 2.8 3 0 0 3 3 3 0 GATA zinc finger zf-C2H2_4 PF13894.1 KOG98648.1 - 4.4 7.8 7.9 27 5.4 1.2 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger NOB1_Zn_bind PF08772.6 KOG98648.1 - 5.9 6.8 8.1 3.4 7.5 0.1 3.5 3 1 1 4 4 4 0 Nin one binding (NOB1) Zn-ribbon like IBR PF01485.16 KOG98648.1 - 6.1 6.7 12.2 59 3.6 1.4 3.1 1 1 1 2 2 2 0 IBR domain Cpn60_TCP1 PF00118.19 KOG98649.1 - 4.1e-141 470.9 2.0 4.7e-141 470.7 1.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family YbjQ_1 PF01906.12 KOG98649.1 - 0.046 14.1 0.0 1.7 9.0 0.0 3.0 3 0 0 3 3 3 0 Putative heavy-metal-binding Resolvase PF00239.16 KOG98649.1 - 0.052 13.4 0.3 3 7.7 0.1 2.5 2 0 0 2 2 2 0 Resolvase, N terminal domain Actin PF00022.14 KOG98650.1 - 3.1e-92 309.0 0.0 6.6e-92 307.9 0.0 1.5 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 KOG98650.1 - 4.3e-05 22.2 0.0 0.046 12.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FAT PF02259.18 KOG98651.1 - 1.3e-130 435.5 0.1 1.3e-130 435.5 0.1 2.4 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.22 KOG98651.1 - 3.3e-62 210.0 0.2 6e-62 209.1 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.3 KOG98651.1 - 2.4e-61 206.3 1.0 2.4e-61 206.3 0.7 4.6 5 0 0 5 5 5 1 Domain of unknown function (DUF3385) Rapamycin_bind PF08771.6 KOG98651.1 - 8.3e-41 138.1 1.2 8.3e-41 138.1 0.8 3.1 3 0 0 3 3 3 1 Rapamycin binding domain FATC PF02260.15 KOG98651.1 - 3.1e-17 61.7 1.8 3.2e-17 61.6 0.1 2.0 2 0 0 2 2 2 1 FATC domain HEAT_2 PF13646.1 KOG98651.1 - 1.1e-16 60.9 7.5 0.00066 19.9 0.0 8.7 6 2 3 9 9 9 5 HEAT repeats HEAT_EZ PF13513.1 KOG98651.1 - 2e-09 37.6 3.9 0.00082 19.7 0.0 9.2 11 1 2 13 13 13 3 HEAT-like repeat HEAT PF02985.17 KOG98651.1 - 1.1e-07 31.3 10.9 0.012 15.6 0.0 7.7 8 0 0 8 8 8 2 HEAT repeat Vac14_Fab1_bd PF12755.2 KOG98651.1 - 4.3e-06 27.0 5.0 0.22 11.9 0.0 5.9 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region HrpB1_HrpK PF09613.5 KOG98651.1 - 0.01 15.3 0.0 0.22 10.9 0.0 2.8 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) Yae1_N PF09811.4 KOG98652.1 - 3.7e-14 51.9 0.1 5.2e-14 51.4 0.1 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Baculo_gp41 PF04700.7 KOG98652.1 - 0.033 13.6 0.1 0.045 13.1 0.1 1.2 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region BBP1_C PF15272.1 KOG98652.1 - 0.04 13.4 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal Romo1 PF10247.4 KOG98652.1 - 0.084 13.0 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 AAA PF00004.24 KOG98653.1 - 7e-16 58.6 0.0 1.4e-15 57.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.6 KOG98653.1 - 8.9e-15 54.4 0.0 1.7e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 KOG98653.1 - 8.9e-13 48.2 0.0 3.8e-12 46.1 0.0 2.0 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.10 KOG98653.1 - 1.5e-08 33.8 0.1 7.5e-07 28.2 0.0 2.2 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein RuvB_N PF05496.7 KOG98653.1 - 2.5e-06 26.7 0.0 4.7e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOG98653.1 - 3.7e-06 27.1 0.0 3.1e-05 24.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KOG98653.1 - 2.9e-05 23.9 0.0 0.00038 20.3 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_11 PF13086.1 KOG98653.1 - 3.2e-05 23.6 0.0 5.1e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOG98653.1 - 0.0001 21.9 0.0 0.0002 21.0 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 KOG98653.1 - 0.00027 20.9 0.0 0.0027 17.7 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.16 KOG98653.1 - 0.00035 19.8 0.0 0.0068 15.5 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.8 KOG98653.1 - 0.0018 17.2 0.0 0.0028 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_24 PF13479.1 KOG98653.1 - 0.0029 17.2 0.4 0.0092 15.5 0.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 KOG98653.1 - 0.0056 16.2 0.0 0.012 15.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.1 KOG98653.1 - 0.0076 16.5 0.1 0.019 15.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOG98653.1 - 0.013 16.3 0.0 0.027 15.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 KOG98653.1 - 0.013 15.3 0.0 0.061 13.1 0.0 2.0 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.4 KOG98653.1 - 0.017 14.1 0.0 0.029 13.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.9 KOG98653.1 - 0.038 13.7 0.2 0.35 10.5 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 KOG98653.1 - 0.057 13.0 0.0 0.55 9.8 0.0 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SNF2_N PF00176.18 KOG98653.1 - 0.063 12.0 0.0 2.1 7.0 0.0 2.2 1 1 0 2 2 2 0 SNF2 family N-terminal domain AAA_18 PF13238.1 KOG98653.1 - 0.071 13.4 0.0 0.23 11.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 KOG98653.1 - 0.084 12.3 0.1 0.19 11.1 0.0 1.6 1 1 1 2 2 2 0 FtsK/SpoIIIE family AAA_25 PF13481.1 KOG98653.1 - 0.085 12.2 0.2 0.28 10.5 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KOG98653.1 - 0.11 12.4 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ham1p_like PF01725.11 KOG98654.1 - 5.3e-53 179.1 0.1 6e-53 179.0 0.1 1.0 1 0 0 1 1 1 1 Ham1 family HEAT_2 PF13646.1 KOG98655.1 - 1.1e-37 128.1 2.0 1e-17 64.1 0.0 3.3 2 1 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.11 KOG98655.1 - 3.2e-22 76.7 2.3 3.9e-05 23.7 0.0 6.3 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.17 KOG98655.1 - 1.5e-10 40.2 5.0 0.26 11.4 0.0 5.9 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.1 KOG98655.1 - 4.8e-07 30.0 6.3 0.02 15.3 0.1 5.2 3 2 3 6 6 6 4 HEAT-like repeat Arm PF00514.18 KOG98655.1 - 0.01 15.6 0.2 4.3 7.3 0.0 3.2 2 1 1 3 3 3 1 Armadillo/beta-catenin-like repeat ATP_bind_1 PF03029.12 KOG98656.1 - 9.8e-86 287.1 0.3 1.5e-85 286.5 0.2 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.22 KOG98656.1 - 4.1e-07 29.6 0.3 8.9e-06 25.2 0.2 2.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 KOG98656.1 - 2.5e-05 25.0 0.9 0.00017 22.3 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOG98656.1 - 3.4e-05 23.7 0.0 0.00012 22.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOG98656.1 - 4.8e-05 23.5 0.0 0.00017 21.7 0.0 1.9 2 0 0 2 2 1 1 AAA domain PduV-EutP PF10662.4 KOG98656.1 - 0.00016 21.2 0.0 0.027 13.9 0.0 2.7 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation AAA_10 PF12846.2 KOG98656.1 - 0.00025 20.5 0.2 0.0017 17.8 0.1 2.0 1 1 0 1 1 1 1 AAA-like domain CbiA PF01656.18 KOG98656.1 - 0.00031 20.1 0.0 0.00068 19.1 0.0 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain NACHT PF05729.7 KOG98656.1 - 0.00039 20.1 0.0 0.0014 18.3 0.0 1.9 2 0 0 2 2 2 1 NACHT domain MMR_HSR1 PF01926.18 KOG98656.1 - 0.00062 19.7 0.0 0.0019 18.1 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.1 KOG98656.1 - 0.0014 18.2 0.0 0.0038 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain FeoB_N PF02421.13 KOG98656.1 - 0.0017 17.6 0.0 0.044 13.0 0.0 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B ArgK PF03308.11 KOG98656.1 - 0.0019 17.0 0.0 0.23 10.2 0.0 2.3 2 0 0 2 2 2 1 ArgK protein SRP54 PF00448.17 KOG98656.1 - 0.0053 16.2 0.0 0.03 13.7 0.0 2.1 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_16 PF13191.1 KOG98656.1 - 0.0068 16.4 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.1 KOG98656.1 - 0.0075 16.5 1.5 0.025 14.9 0.0 2.5 2 1 0 2 2 2 1 AAA domain Arf PF00025.16 KOG98656.1 - 0.008 15.4 0.0 0.63 9.2 0.0 3.0 2 1 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.5 KOG98656.1 - 0.0097 15.1 0.2 0.78 8.9 0.0 2.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit cobW PF02492.14 KOG98656.1 - 0.014 14.8 0.1 0.23 10.8 0.1 2.4 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PRK PF00485.13 KOG98656.1 - 0.018 14.6 0.0 0.059 12.9 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family FadA PF09403.5 KOG98656.1 - 0.018 15.0 2.3 0.041 13.8 0.2 2.2 2 0 0 2 2 2 0 Adhesion protein FadA KTI12 PF08433.5 KOG98656.1 - 0.02 14.0 0.1 0.093 11.9 0.0 2.0 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Miro PF08477.8 KOG98656.1 - 0.021 15.3 0.0 4.8 7.6 0.0 2.6 2 0 0 2 2 2 0 Miro-like protein MobB PF03205.9 KOG98656.1 - 0.026 14.2 0.0 0.074 12.7 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 KOG98656.1 - 0.032 13.8 0.0 0.062 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOG98656.1 - 0.059 12.5 0.0 0.96 8.6 0.0 2.6 1 1 0 1 1 1 0 Protein of unknown function, DUF258 NB-ARC PF00931.17 KOG98656.1 - 0.14 10.9 1.3 0.26 10.1 0.1 1.9 2 0 0 2 2 2 0 NB-ARC domain Glyco_tranf_2_3 PF13641.1 KOG98656.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 PEMT PF04191.8 KOG98657.1 - 7.2e-35 119.2 1.7 7.2e-35 119.2 1.2 1.7 2 0 0 2 2 2 1 Phospholipid methyltransferase Tmemb_170 PF10190.4 KOG98657.1 - 0.087 12.8 0.8 2.2 8.3 0.0 2.3 2 1 0 2 2 2 0 Putative transmembrane protein 170 Gly_transf_sug PF04488.10 KOG98658.1 - 1.9e-15 57.1 0.1 7.1e-15 55.2 0.0 2.0 2 1 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif DUF3450 PF11932.3 KOG98658.1 - 0.0077 15.5 1.6 0.011 15.0 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) BBP1_C PF15272.1 KOG98658.1 - 0.018 14.5 2.9 0.028 13.9 0.8 1.9 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal UPF0118 PF01594.11 KOG98658.1 - 0.051 12.5 0.4 0.08 11.9 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF20 IncA PF04156.9 KOG98658.1 - 0.068 12.7 2.3 0.12 12.0 1.6 1.3 1 0 0 1 1 1 0 IncA protein Septin PF00735.13 KOG98659.1 - 1.4e-109 365.4 0.0 1.4e-109 365.4 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 KOG98659.1 - 2e-08 34.1 0.0 6.3e-08 32.5 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 KOG98659.1 - 1.8e-05 24.6 7.5 0.00051 19.9 0.2 3.0 2 1 1 3 3 3 2 Dynamin family ABC_tran PF00005.22 KOG98659.1 - 4.6e-05 23.7 1.1 0.00023 21.4 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AIG1 PF04548.11 KOG98659.1 - 4.9e-05 22.5 0.1 4.9e-05 22.5 0.0 2.0 2 0 0 2 2 2 1 AIG1 family DUF258 PF03193.11 KOG98659.1 - 6.8e-05 22.1 1.3 0.00044 19.4 0.9 2.1 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_10 PF12846.2 KOG98659.1 - 0.0022 17.4 0.0 0.0038 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA-like domain IIGP PF05049.8 KOG98659.1 - 0.0024 16.7 0.1 0.0042 15.9 0.1 1.3 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Miro PF08477.8 KOG98659.1 - 0.0026 18.2 1.1 0.0045 17.4 0.0 1.9 2 0 0 2 2 2 1 Miro-like protein AAA_17 PF13207.1 KOG98659.1 - 0.0067 17.2 0.9 0.032 15.0 0.0 2.5 3 1 0 3 3 3 1 AAA domain AAA_29 PF13555.1 KOG98659.1 - 0.031 13.7 0.4 0.1 12.1 0.3 1.9 1 1 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.22 KOG98659.1 - 0.038 13.4 0.4 0.44 9.9 0.2 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.4 KOG98659.1 - 0.054 12.9 0.8 2 7.8 0.2 2.5 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 KOG98659.1 - 0.058 13.0 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.13 KOG98659.1 - 0.066 12.6 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family FeoB_N PF02421.13 KOG98659.1 - 0.11 11.8 2.3 0.36 10.0 0.3 2.4 2 1 0 2 2 2 0 Ferrous iron transport protein B Mito_carr PF00153.22 KOG98660.1 - 9.1e-47 156.7 8.7 6e-19 67.5 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein IDO PF01231.13 KOG98661.1 - 9.6e-150 498.6 0.0 1.2e-149 498.3 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.6 KOG98661.1 - 0.021 13.3 0.2 0.15 10.5 0.2 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF1864) AIM24 PF01987.12 KOG98662.1 - 7.1e-07 28.8 0.0 3.9e-06 26.4 0.0 2.2 1 1 0 1 1 1 1 Mitochondrial biogenesis AIM24 NuA4 PF09340.5 KOG98663.1 - 1.6e-19 69.2 11.5 6.8e-18 64.0 8.0 2.1 1 1 0 1 1 1 1 Histone acetyltransferase subunit NuA4 CENP-Q PF13094.1 KOG98663.1 - 0.0098 15.9 3.7 0.0098 15.9 2.5 1.3 1 1 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit IncA PF04156.9 KOG98663.1 - 1.2 8.7 3.9 1.8 8.0 2.7 1.2 1 0 0 1 1 1 0 IncA protein TPD52 PF04201.10 KOG98664.1 - 0.013 15.2 2.1 0.022 14.4 1.5 1.3 1 0 0 1 1 1 0 Tumour protein D52 family Tropomyosin_1 PF12718.2 KOG98664.1 - 0.2 11.4 11.4 0.02 14.7 4.4 1.9 2 0 0 2 2 2 0 Tropomyosin like IncA PF04156.9 KOG98664.1 - 0.27 10.8 5.3 0.47 10.0 3.7 1.5 1 0 0 1 1 1 0 IncA protein PCI PF01399.22 KOG98665.1 - 4.6e-13 49.3 0.1 1.5e-12 47.7 0.0 2.0 2 0 0 2 2 2 1 PCI domain Tmemb_14 PF03647.8 KOG98666.1 - 1.2e-24 86.5 7.8 1.3e-24 86.4 5.4 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF3816 PF12822.2 KOG98666.1 - 0.077 12.8 1.2 0.12 12.2 0.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) G-gamma PF00631.17 KOG98667.1 - 1.1e-27 95.5 0.2 1.7e-27 94.9 0.1 1.3 1 0 0 1 1 1 1 GGL domain Herpes_UL95 PF03038.9 KOG98667.1 - 0.013 14.4 0.2 0.016 14.0 0.1 1.1 1 0 0 1 1 1 0 UL95 family GnsAB PF08178.6 KOG98667.1 - 0.11 12.2 0.4 0.15 11.7 0.2 1.2 1 0 0 1 1 1 0 GnsA/GnsB family Mitofilin PF09731.4 KOG98667.1 - 0.33 9.5 4.5 0.44 9.1 3.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein FYVE_2 PF02318.11 KOG98667.1 - 3.7 7.4 6.5 0.55 10.1 1.5 1.9 2 1 1 3 3 3 0 FYVE-type zinc finger TPR_16 PF13432.1 KOG98668.1 - 0.00076 20.0 1.5 0.035 14.7 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOG98668.1 - 0.0014 19.0 0.7 8.9 7.2 0.0 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOG98668.1 - 0.0024 17.6 7.2 0.12 12.3 0.1 3.9 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOG98668.1 - 0.0036 17.6 6.5 1.9 9.1 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOG98668.1 - 0.0042 16.6 1.3 0.14 11.7 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOG98668.1 - 0.0056 16.3 0.1 4.2 7.3 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOG98668.1 - 0.0065 16.3 1.2 4.5 7.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOG98668.1 - 0.01 15.4 3.9 0.2 11.3 0.3 2.8 3 1 1 4 4 4 0 TPR repeat TPR_19 PF14559.1 KOG98668.1 - 0.013 15.7 0.8 1.1 9.6 0.0 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOG98668.1 - 0.025 14.3 3.6 1.3 8.9 0.0 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOG98668.1 - 0.04 13.8 0.1 0.15 12.0 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat BIR PF00653.16 KOG98669.1 - 2.7e-26 91.7 6.2 5.1e-16 58.8 0.4 2.7 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain F-box-like PF12937.2 KOG98670.1 - 2.6e-05 23.8 0.2 6.1e-05 22.6 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 KOG98670.1 - 0.0051 16.4 0.1 0.015 14.9 0.1 1.9 1 0 0 1 1 1 1 F-box domain PUF PF00806.14 KOG98671.1 - 5.4e-32 107.4 0.0 1.9e-06 27.0 0.0 5.8 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat RRM_1 PF00076.17 KOG98671.1 - 5.1e-08 32.4 0.0 1.4e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG98671.1 - 8.4e-06 25.5 0.0 2.4e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG98671.1 - 0.00053 19.9 0.0 0.0016 18.3 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Anillin PF08174.6 KOG98672.1 - 6.1e-14 52.2 0.1 6.1e-14 52.2 0.1 2.8 2 1 1 3 3 3 1 Cell division protein anillin PH PF00169.24 KOG98672.1 - 1.9e-09 37.6 0.8 1.4e-08 34.8 0.2 3.0 2 0 0 2 2 2 1 PH domain Fip1 PF05182.8 KOG98673.1 - 1.8e-22 78.2 0.6 3.1e-22 77.5 0.4 1.4 1 0 0 1 1 1 1 Fip1 motif DUF3828 PF12883.2 KOG98674.1 - 6.3 6.7 11.4 1 9.2 4.4 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3828) Ribosomal_L37ae PF01780.14 KOG98675.1 - 9.6e-40 134.3 9.2 1.1e-39 134.2 6.4 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family DUF1364 PF07102.7 KOG98675.1 - 0.0044 16.8 0.9 0.0055 16.5 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1364) Rep_fac-A_C PF08646.5 KOG98675.1 - 0.006 16.2 0.4 0.0073 16.0 0.3 1.2 1 0 0 1 1 1 1 Replication factor-A C terminal domain Zn_Tnp_IS1595 PF12760.2 KOG98675.1 - 0.017 14.8 2.7 0.028 14.2 1.9 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Sgf11 PF08209.6 KOG98675.1 - 0.019 14.2 0.6 0.4 10.0 0.0 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) C1_1 PF00130.17 KOG98675.1 - 0.049 13.3 1.7 0.074 12.7 1.2 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CarbpepA_inh PF02977.10 KOG98675.1 - 0.053 13.1 3.9 0.11 12.1 0.5 2.1 1 1 1 2 2 2 0 Carboxypeptidase A inhibitor zf-H2C2_2 PF13465.1 KOG98675.1 - 0.13 12.6 1.2 1.3 9.3 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zf-C4_ClpX PF06689.8 KOG98675.1 - 0.15 11.6 0.3 0.15 11.6 0.2 2.1 2 0 0 2 2 2 0 ClpX C4-type zinc finger zinc_ribbon_2 PF13240.1 KOG98675.1 - 0.17 11.4 1.6 0.9 9.1 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 KOG98675.1 - 0.21 11.2 3.0 0.32 10.6 2.0 1.4 1 1 0 1 1 1 0 Putative transposase DNA-binding domain Elf1 PF05129.8 KOG98675.1 - 0.22 11.2 2.7 0.5 10.0 1.8 1.7 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like A2L_zn_ribbon PF08792.5 KOG98675.1 - 0.43 10.1 2.3 9.7 5.7 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain Mito_carr PF00153.22 KOG98676.1 - 2.8e-75 248.0 1.2 1.4e-24 85.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Cas_GSU0053 PF09617.5 KOG98676.1 - 0.076 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein GSU0053 (Cas_GSU0053) Aldo_ket_red PF00248.16 KOG98677.1 - 1.8e-48 164.8 0.0 2.1e-48 164.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DnaJ PF00226.26 KOG98678.1 - 2.1e-18 65.7 0.7 3.1e-18 65.2 0.5 1.2 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.8 KOG98678.1 - 1.9e-16 59.2 1.9 3.6e-16 58.4 1.3 1.5 1 0 0 1 1 1 1 CSL zinc finger YedD PF13987.1 KOG98678.1 - 0.031 13.8 0.1 0.049 13.2 0.1 1.3 1 0 0 1 1 1 0 YedD-like protein RPA_interact_C PF14768.1 KOG98678.1 - 0.035 14.4 0.9 7.1 7.0 0.0 2.3 2 0 0 2 2 2 0 Replication protein A interacting C-terminal RPT PF13446.1 KOG98678.1 - 0.056 12.8 0.0 0.94 8.9 0.0 2.3 2 0 0 2 2 2 0 A repeated domain in UCH-protein DUF3811 PF11656.3 KOG98678.1 - 0.42 10.7 2.1 0.86 9.7 1.4 1.5 1 1 0 1 1 1 0 YjbD family (DUF3811) LCAT PF02450.10 KOG98679.1 - 6.9e-08 31.8 0.6 4e-07 29.3 0.4 2.0 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase PGAP1 PF07819.8 KOG98679.1 - 1.6e-06 27.8 0.0 3.5e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 KOG98679.1 - 6.1e-05 23.0 0.0 8.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.7 KOG98679.1 - 0.0003 20.1 0.0 0.00065 19.0 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_8 PF06259.7 KOG98679.1 - 0.0028 17.1 0.0 0.005 16.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase Abhydrolase_1 PF00561.15 KOG98679.1 - 0.0079 15.7 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOG98679.1 - 0.0099 15.6 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2305 PF10230.4 KOG98679.1 - 0.036 13.4 0.5 0.073 12.4 0.1 1.6 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2305) Ser_hydrolase PF06821.8 KOG98679.1 - 0.14 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase Peptidase_C12 PF01088.16 KOG98680.1 - 3.5e-51 173.4 0.0 4.3e-51 173.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Scramblase PF03803.10 KOG98681.1 - 1.2e-78 263.1 0.3 1.5e-78 262.9 0.2 1.1 1 0 0 1 1 1 1 Scramblase KRTDAP PF15200.1 KOG98681.1 - 0.1 12.4 0.1 0.38 10.5 0.1 2.0 1 0 0 1 1 1 0 Keratinocyte differentiation-associated Ribosomal_L5_C PF00673.16 KOG98681.1 - 0.1 12.3 0.8 3.2 7.5 0.0 2.7 3 0 0 3 3 3 0 ribosomal L5P family C-terminus Sod_Fe_C PF02777.13 KOG98682.1 - 1.1e-11 44.5 2.8 3e-06 27.0 1.1 2.8 1 1 2 3 3 3 2 Iron/manganese superoxide dismutases, C-terminal domain Pik1 PF11522.3 KOG98682.1 - 0.0034 17.0 0.2 0.0034 17.0 0.2 2.4 3 0 0 3 3 3 1 Yeast phosphatidylinositol-4-OH kinase Pik1 ESCRT-II PF05871.7 KOG98683.1 - 5.5e-51 172.1 1.9 6.8e-51 171.8 1.3 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit Phage_T4_gp19 PF06841.7 KOG98683.1 - 0.16 11.5 1.1 0.37 10.4 0.1 1.8 2 0 0 2 2 2 0 T4-like virus tail tube protein gp19 CTP_synth_N PF06418.9 KOG98684.1 - 1e-119 398.6 0.2 1.4e-119 398.2 0.1 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 KOG98684.1 - 1.4e-60 204.0 0.0 2.1e-60 203.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 KOG98684.1 - 4.8e-05 22.9 0.0 0.00018 21.0 0.0 2.0 2 1 0 2 2 2 1 Peptidase C26 CbiA PF01656.18 KOG98684.1 - 0.0011 18.4 0.0 0.0045 16.4 0.0 1.9 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain Sod_Cu PF00080.15 KOG98685.1 - 2e-46 157.6 1.8 2.3e-46 157.4 1.3 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) PfkB PF00294.19 KOG98686.1 - 1.9e-76 257.0 2.3 2.2e-76 256.8 1.6 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 KOG98686.1 - 7.7e-07 28.5 0.0 1.4e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Na_Ca_ex PF01699.19 KOG98687.1 - 1.3e-61 206.2 23.7 2e-40 137.6 4.3 2.9 3 1 0 3 3 3 2 Sodium/calcium exchanger protein Lipase_3 PF01764.20 KOG98688.1 - 1.5e-45 154.2 0.0 2.2e-45 153.7 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 KOG98688.1 - 0.02 14.2 0.0 0.43 9.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_5 PF12695.2 KOG98688.1 - 0.026 14.3 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOG98688.1 - 0.026 14.3 0.0 0.028 14.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Cutinase PF01083.17 KOG98688.1 - 0.056 13.1 0.0 0.097 12.4 0.0 1.3 1 0 0 1 1 1 0 Cutinase Abhydrolase_1 PF00561.15 KOG98688.1 - 0.15 11.5 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold CPSase_L_D2 PF02786.12 KOG98690.1 - 1.7e-108 360.7 0.0 1.4e-82 276.1 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.14 KOG98690.1 - 4.5e-37 126.5 0.2 4.5e-37 126.5 0.1 2.2 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 KOG98690.1 - 7e-37 126.9 0.9 5.5e-21 75.1 0.0 2.8 3 0 0 3 3 3 2 ATP-grasp domain CPSase_L_chain PF00289.17 KOG98690.1 - 3.9e-34 117.0 0.0 2.9e-17 62.7 0.0 2.6 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATPgrasp_Ter PF15632.1 KOG98690.1 - 8.1e-24 83.9 0.0 9.8e-12 44.2 0.0 3.6 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 KOG98690.1 - 1.5e-17 63.5 0.0 1.2e-07 31.2 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.8 KOG98690.1 - 8.3e-14 51.4 0.2 4.9e-06 26.0 0.1 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus MGS PF02142.17 KOG98690.1 - 2.1e-05 24.3 0.2 9.5e-05 22.2 0.0 2.3 3 0 0 3 3 2 1 MGS-like domain ATP-grasp_3 PF02655.9 KOG98690.1 - 0.00012 21.9 0.1 0.67 9.8 0.0 2.8 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.14 KOG98690.1 - 0.00017 21.2 0.2 0.074 12.6 0.1 2.7 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_5 PF13549.1 KOG98690.1 - 0.00039 19.6 0.0 0.035 13.3 0.0 2.5 2 0 0 2 2 2 1 ATP-grasp domain Epimerase PF01370.16 KOG98690.1 - 0.012 15.1 0.1 0.19 11.1 0.0 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DUF4561 PF15120.1 KOG98690.1 - 0.012 15.0 0.1 0.034 13.6 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4561) Myotub-related PF06602.9 KOG98691.1 - 4.7e-141 469.6 1.3 6e-141 469.3 0.9 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.22 KOG98691.1 - 0.00043 19.7 0.0 0.0011 18.2 0.0 1.7 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 KOG98691.1 - 0.016 15.4 0.0 0.036 14.3 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family GRAM PF02893.15 KOG98691.1 - 0.018 14.5 0.6 0.049 13.1 0.0 2.1 2 0 0 2 2 2 0 GRAM domain DSPc PF00782.15 KOG98691.1 - 0.026 14.1 0.1 0.088 12.3 0.0 1.9 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain CMD PF02627.15 KOG98692.1 - 1e-06 28.4 0.0 7.7e-06 25.6 0.0 2.2 3 0 0 3 3 3 1 Carboxymuconolactone decarboxylase family Nnf1 PF03980.9 KOG98693.1 - 6.3e-31 106.6 4.2 1.3e-30 105.5 2.9 1.6 1 0 0 1 1 1 1 Nnf1 Psu PF07455.6 KOG98693.1 - 0.0046 16.4 0.2 0.0094 15.4 0.1 1.5 1 0 0 1 1 1 1 Phage polarity suppression protein (Psu) ALIX_LYPXL_bnd PF13949.1 KOG98693.1 - 0.0086 15.0 1.1 0.0086 15.0 0.8 2.0 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV DUF948 PF06103.6 KOG98693.1 - 0.023 14.5 0.6 7.4 6.5 0.1 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) V_ATPase_I PF01496.14 KOG98693.1 - 0.033 12.0 2.5 0.038 11.8 1.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UPF0184 PF03670.8 KOG98693.1 - 0.043 13.9 1.0 0.043 13.9 0.7 2.0 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0184) 7TMR-HDED PF07697.6 KOG98693.1 - 0.051 13.2 3.1 0.34 10.6 0.5 2.2 1 1 1 2 2 2 0 7TM-HD extracellular BTV_NS2 PF04514.7 KOG98693.1 - 0.064 12.1 3.1 0.084 11.7 2.1 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Guanylate_kin PF00625.16 KOG98693.1 - 0.066 12.6 2.0 0.74 9.2 0.1 2.1 2 0 0 2 2 2 0 Guanylate kinase Prominin PF05478.6 KOG98693.1 - 0.11 10.0 2.3 0.14 9.6 0.4 1.5 1 1 1 2 2 2 0 Prominin VIT1 PF01988.14 KOG98693.1 - 0.22 10.9 3.0 2.6 7.4 0.2 2.1 1 1 1 2 2 2 0 VIT family CR6_interact PF10147.4 KOG98693.1 - 0.24 10.6 3.1 1.1 8.5 0.3 2.1 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 HAUS6_N PF14661.1 KOG98693.1 - 0.25 10.6 2.7 0.84 8.9 0.2 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus TBPIP PF07106.8 KOG98693.1 - 0.25 10.8 9.6 0.02 14.4 1.7 2.1 2 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) NPV_P10 PF05531.7 KOG98693.1 - 0.37 11.0 2.6 0.9 9.8 0.1 2.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Syntaxin PF00804.20 KOG98693.1 - 0.43 10.7 6.3 0.25 11.5 0.6 2.4 2 1 0 2 2 2 0 Syntaxin DASH_Dad2 PF08654.5 KOG98693.1 - 0.67 9.9 3.7 0.34 10.9 0.4 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad2 ATG16 PF08614.6 KOG98693.1 - 0.67 9.7 8.6 0.49 10.1 2.3 2.5 2 2 0 2 2 2 0 Autophagy protein 16 (ATG16) V-SNARE PF05008.10 KOG98693.1 - 0.79 9.9 8.5 1.8 8.8 1.1 2.7 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DMPK_coil PF08826.5 KOG98693.1 - 0.88 9.5 10.8 0.052 13.4 1.8 2.8 3 0 0 3 3 3 0 DMPK coiled coil domain like DUF793 PF05633.6 KOG98693.1 - 1 8.0 4.5 1.6 7.4 1.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF793) IncA PF04156.9 KOG98693.1 - 1.1 8.8 14.0 49 3.4 9.7 2.3 1 1 0 1 1 1 0 IncA protein Nsp1_C PF05064.8 KOG98693.1 - 1.3 8.7 6.4 0.44 10.2 1.3 2.4 3 0 0 3 3 3 0 Nsp1-like C-terminal region Occludin_ELL PF07303.8 KOG98693.1 - 2.9 8.6 6.2 4.4 8.0 0.5 2.6 2 1 1 3 3 3 0 Occludin homology domain Kinetocho_Slk19 PF12709.2 KOG98693.1 - 3 8.0 6.7 0.46 10.5 1.3 2.1 2 0 0 2 2 2 0 Central kinetochore-associated DivIC PF04977.10 KOG98693.1 - 6.8 6.2 9.4 0.26 10.7 1.0 2.5 3 0 0 3 3 3 0 Septum formation initiator VanZ PF04892.7 KOG98694.1 - 4.3e-08 33.1 0.6 4.8e-08 33.0 0.4 1.1 1 0 0 1 1 1 1 VanZ like family Cation_ATPase_C PF00689.16 KOG98694.1 - 0.025 14.0 0.4 0.03 13.8 0.3 1.1 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus SpoIID PF08486.5 KOG98694.1 - 0.03 14.5 0.0 0.034 14.4 0.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein Ribosomal_S7 PF00177.16 KOG98695.1 - 6.7e-31 106.8 0.0 9.7e-31 106.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e TRAM_LAG1_CLN8 PF03798.11 KOG98697.1 - 2.6e-30 105.4 17.5 2.6e-30 105.4 12.1 1.5 2 0 0 2 2 2 1 TLC domain Peptidase_M48 PF01435.13 KOG98698.1 - 5.8e-53 179.7 0.0 8.2e-53 179.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 DUF2268 PF10026.4 KOG98698.1 - 0.0046 16.3 0.0 0.0086 15.4 0.0 1.3 1 0 0 1 1 1 1 Predicted Zn-dependent protease (DUF2268) Peptidase_M56 PF05569.6 KOG98698.1 - 0.0072 15.3 0.2 0.017 14.0 0.1 1.6 1 0 0 1 1 1 1 BlaR1 peptidase M56 Ilm1 PF10311.4 KOG98699.1 - 2.2e-45 154.0 10.3 3.1e-45 153.6 7.2 1.2 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 DUF1971 PF09313.6 KOG98699.1 - 0.11 12.2 0.0 0.37 10.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1971) CTP_transf_1 PF01148.15 KOG98699.1 - 2.6 7.6 7.1 7.8 6.0 4.9 1.7 1 1 0 1 1 1 0 Cytidylyltransferase family JmjC PF02373.17 KOG98700.1 - 6.6e-41 139.1 0.2 1.7e-40 137.8 0.1 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.12 KOG98700.1 - 1.9e-12 46.4 0.1 5.6e-12 44.9 0.1 1.9 1 0 0 1 1 1 1 jmjN domain PHD PF00628.24 KOG98700.1 - 6.6e-12 44.9 3.8 6.6e-12 44.9 2.7 2.4 2 0 0 2 2 2 1 PHD-finger Lar_restr_allev PF14354.1 KOG98700.1 - 0.015 15.5 2.0 0.093 13.0 0.0 2.6 2 0 0 2 2 2 0 Restriction alleviation protein Lar PHD_2 PF13831.1 KOG98700.1 - 0.085 12.1 1.7 0.5 9.7 0.2 2.6 2 0 0 2 2 2 0 PHD-finger DZR PF12773.2 KOG98700.1 - 1.6 8.5 9.6 13 5.7 3.7 3.2 3 1 0 3 3 3 0 Double zinc ribbon ATP-synt_ab PF00006.20 KOG98701.1 - 1.1e-62 211.4 0.0 1.6e-62 210.7 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 KOG98701.1 - 2.8e-26 92.2 0.3 5.6e-26 91.2 0.2 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 KOG98701.1 - 5.6e-24 84.1 0.8 1.4e-23 82.8 0.6 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain KaiC PF06745.8 KOG98701.1 - 0.0007 18.7 0.2 0.0012 18.0 0.1 1.4 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.1 KOG98701.1 - 0.0056 16.0 0.0 0.014 14.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain MobB PF03205.9 KOG98701.1 - 0.013 15.1 0.1 0.57 9.8 0.0 2.9 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.7 KOG98701.1 - 0.021 14.4 0.1 0.068 12.8 0.0 1.9 2 0 0 2 2 2 0 NACHT domain NB-ARC PF00931.17 KOG98701.1 - 0.032 13.0 0.8 0.53 9.0 0.1 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA PF00004.24 KOG98701.1 - 0.035 14.3 0.1 0.52 10.5 0.0 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 KOG98701.1 - 0.043 13.0 0.1 0.084 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 KOG98701.1 - 0.061 13.2 0.6 0.25 11.2 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain Arch_ATPase PF01637.13 KOG98701.1 - 0.083 12.5 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Archaeal ATPase AAA_22 PF13401.1 KOG98701.1 - 0.086 12.9 0.0 0.33 11.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOG98701.1 - 0.088 12.9 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase GCV_T PF01571.16 KOG98702.1 - 2.3e-06 27.1 0.0 0.02 14.2 0.0 2.9 3 0 0 3 3 3 2 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 KOG98702.1 - 0.0038 17.2 0.0 0.0072 16.3 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Ribosomal_S7 PF00177.16 KOG98703.1 - 9e-40 135.6 1.8 1.2e-39 135.2 1.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e MFS_1 PF07690.11 KOG98704.1 - 4.3e-25 88.1 21.6 8e-18 64.2 12.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOG98704.1 - 5.1e-07 28.4 27.9 1.8e-06 26.6 9.0 2.5 1 1 2 3 3 3 3 MFS/sugar transport protein Sugar_tr PF00083.19 KOG98704.1 - 7.3e-05 21.5 9.8 7.3e-05 21.5 6.8 2.9 2 1 0 3 3 3 1 Sugar (and other) transporter ATG22 PF11700.3 KOG98704.1 - 0.00013 20.5 10.9 0.00013 20.5 7.6 3.2 3 1 0 3 3 3 1 Vacuole effluxer Atg22 like MFS_1_like PF12832.2 KOG98704.1 - 0.011 15.5 8.9 0.014 15.2 0.2 4.2 4 0 0 4 4 4 0 MFS_1 like family MFS_3 PF05977.8 KOG98704.1 - 2.4 6.1 9.7 1.8 6.5 0.1 2.9 2 2 0 2 2 2 0 Transmembrane secretion effector ENTH PF01417.15 KOG98705.1 - 5.3e-45 152.3 0.1 1.1e-44 151.2 0.1 1.6 1 0 0 1 1 1 1 ENTH domain VHS PF00790.14 KOG98705.1 - 0.00029 20.4 0.0 0.00047 19.7 0.0 1.3 1 0 0 1 1 1 1 VHS domain ANTH PF07651.11 KOG98705.1 - 0.0013 17.4 0.0 0.0019 16.9 0.0 1.2 1 0 0 1 1 1 1 ANTH domain DUF3991 PF13154.1 KOG98705.1 - 0.072 13.2 0.1 3.7 7.7 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3991) Peptidase_M28 PF04389.12 KOG98706.1 - 1e-12 48.1 0.1 2e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.10 KOG98706.1 - 2.9e-06 26.8 0.0 5.7e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.17 KOG98706.1 - 0.0054 16.4 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 PA domain zf-C2H2 PF00096.21 KOG98707.1 - 4.1e-05 23.6 13.5 0.0063 16.7 3.1 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KOG98707.1 - 0.00015 21.8 12.0 0.0061 16.7 4.6 2.7 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOG98707.1 - 0.03 14.6 13.8 0.46 10.9 2.9 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger Methyltransf_16 PF10294.4 KOG98708.1 - 4.5e-24 84.8 0.0 6.7e-24 84.2 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 KOG98708.1 - 6.4e-06 25.9 0.0 1.1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 KOG98708.1 - 0.00035 19.6 0.0 0.00058 18.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_18 PF12847.2 KOG98708.1 - 0.0062 17.1 0.0 0.012 16.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOG98708.1 - 0.0094 15.3 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 KOG98708.1 - 0.011 15.3 0.0 0.022 14.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 KOG98708.1 - 0.025 15.0 0.0 0.046 14.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.1 KOG98708.1 - 0.047 13.3 0.0 0.089 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 KOG98708.1 - 0.17 11.9 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Cys_Met_Meta_PP PF01053.15 KOG98709.1 - 4.7e-27 94.2 0.0 1.1e-26 92.9 0.0 1.7 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme PDE6_gamma PF04868.7 KOG98709.1 - 0.01 15.6 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 Retinal cGMP phosphodiesterase, gamma subunit Aminotran_1_2 PF00155.16 KOG98709.1 - 0.038 12.9 0.0 0.065 12.1 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Glyco_hydro_47 PF01532.15 KOG98710.1 - 1.5e-142 475.4 0.8 1.7e-142 475.2 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 IBN_N PF03810.14 KOG98711.1 - 1.9e-17 62.8 0.0 1.4e-15 56.9 0.0 3.6 3 0 0 3 3 3 1 Importin-beta N-terminal domain Pribosyltran PF00156.22 KOG98712.1 - 6.7e-13 48.4 0.3 4.6e-12 45.7 0.2 2.0 1 1 0 1 1 1 1 Phosphoribosyl transferase domain TMF_TATA_bd PF12325.3 KOG98713.1 - 2.1e-37 127.5 18.4 2.1e-37 127.5 12.8 5.8 3 2 2 5 5 5 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 KOG98713.1 - 1.6e-16 59.8 4.7 1.6e-16 59.8 3.3 9.4 5 3 4 9 9 9 1 TATA element modulatory factor 1 DNA binding AAA_13 PF13166.1 KOG98713.1 - 0.33 9.3 76.6 0.073 11.5 21.1 3.2 1 1 1 3 3 3 0 AAA domain Lebercilin PF15619.1 KOG98713.1 - 8.1 5.8 77.8 0.038 13.4 11.6 4.0 3 1 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease zf-Tim10_DDP PF02953.10 KOG98715.1 - 6.2e-22 76.6 1.6 7.6e-22 76.3 1.1 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger ATP11 PF06644.6 KOG98715.1 - 0.1 12.0 0.1 0.17 11.3 0.1 1.5 1 1 0 1 1 1 0 ATP11 protein DUF2454 PF10521.4 KOG98716.1 - 3.7e-71 239.4 7.2 6e-71 238.7 5.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2454) NIR_SIR PF01077.17 KOG98717.1 - 6.2e-57 191.3 0.0 7.7e-53 178.0 0.0 2.5 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain Flavodoxin_1 PF00258.20 KOG98717.1 - 4.2e-30 104.6 0.1 8.8e-30 103.5 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NIR_SIR_ferr PF03460.12 KOG98717.1 - 9.3e-28 95.6 0.1 1.4e-12 47.0 0.0 2.5 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain TraF PF13728.1 KOG98717.1 - 0.015 14.7 0.0 0.031 13.7 0.0 1.4 1 0 0 1 1 1 0 F plasmid transfer operon protein Flavodoxin_NdrI PF07972.6 KOG98717.1 - 0.059 13.2 0.0 0.2 11.5 0.0 1.9 1 0 0 1 1 1 0 NrdI Flavodoxin like Flavodoxin_3 PF12641.2 KOG98717.1 - 0.11 11.9 0.0 0.24 10.8 0.0 1.6 1 0 0 1 1 1 0 Flavodoxin domain DUF3608 PF12257.3 KOG98718.1 - 5.8e-144 478.1 3.8 5.8e-144 478.1 2.6 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3608) DEP PF00610.16 KOG98718.1 - 6.1e-25 86.7 0.8 1.7e-24 85.3 0.6 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Homoserine_dh PF00742.14 KOG98719.1 - 2.3e-54 183.7 0.1 3.3e-54 183.2 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.11 KOG98719.1 - 1.7e-27 96.1 0.0 3.4e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain 6PF2K PF01591.13 KOG98719.1 - 0.041 12.9 0.1 0.071 12.1 0.1 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase HECT_2 PF09814.4 KOG98721.1 - 2.6e-80 269.8 0.1 2.9e-80 269.6 0.1 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding NUDIX PF00293.23 KOG98722.1 - 5.2e-08 32.6 0.0 3.5e-06 26.6 0.0 2.2 2 0 0 2 2 2 2 NUDIX domain PMT PF02366.13 KOG98723.1 - 7.3e-83 277.6 22.5 1.4e-82 276.7 15.6 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 KOG98723.1 - 1.6e-26 93.0 0.3 2.8e-26 92.2 0.2 1.4 1 0 0 1 1 1 1 MIR domain Mgm101p PF06420.7 KOG98724.1 - 2.4e-91 303.6 0.1 3.2e-91 303.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Rad52_Rad22 PF04098.10 KOG98724.1 - 0.073 12.8 0.0 0.14 11.8 0.0 1.6 1 1 0 1 1 1 0 Rad52/22 family double-strand break repair protein Ribosomal_S4e PF00900.15 KOG98725.1 - 3.5e-34 116.3 1.3 1.4e-32 111.1 0.4 2.3 2 0 0 2 2 2 1 Ribosomal family S4e KOW PF00467.24 KOG98725.1 - 7.4e-06 25.4 1.5 7.4e-06 25.4 1.0 3.6 4 0 0 4 4 4 1 KOW motif S4 PF01479.20 KOG98725.1 - 0.00028 20.2 0.0 0.00069 18.9 0.0 1.7 1 0 0 1 1 1 1 S4 domain Cache_1 PF02743.13 KOG98725.1 - 0.097 12.2 0.1 0.29 10.7 0.0 1.9 2 0 0 2 2 2 0 Cache domain HSF_DNA-bind PF00447.12 KOG98726.1 - 4.3e-19 68.5 1.3 4.3e-19 68.5 0.9 1.9 2 0 0 2 2 2 1 HSF-type DNA-binding Aminotran_4 PF01063.14 KOG98727.1 - 4.1e-31 108.2 0.0 5e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV SRP1_TIP1 PF00660.12 KOG98728.1 - 2.3e-30 104.4 0.1 5.9e-30 103.1 0.1 1.7 1 0 0 1 1 1 1 Seripauperin and TIP1 family MFS_1 PF07690.11 KOG98729.1 - 3.2e-24 85.2 12.5 3.2e-24 85.2 8.7 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily NMO PF03060.10 KOG98730.1 - 1.4e-49 169.0 0.0 1.7e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 KOG98730.1 - 5.7e-08 32.0 1.0 0.0015 17.5 0.1 2.1 1 1 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain DHO_dh PF01180.16 KOG98730.1 - 0.096 11.6 0.1 0.18 10.6 0.0 1.4 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase MFS_1 PF07690.11 KOG98731.1 - 6e-31 107.4 25.0 6e-31 107.4 17.3 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily ESSS PF10183.4 KOG98731.1 - 0.07 13.5 0.6 0.23 11.8 0.0 2.2 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Pox_A14 PF05767.7 KOG98731.1 - 0.32 10.9 6.4 6.2 6.8 0.5 3.5 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 Glyco_hydro_28 PF00295.12 KOG98732.1 - 5e-100 334.6 20.9 5.7e-100 334.4 14.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.1 KOG98732.1 - 2.9e-06 27.1 62.2 0.00025 20.8 19.6 2.8 1 1 2 3 3 3 3 Right handed beta helix region Melibiase PF02065.13 KOG98733.1 - 5.9e-73 245.8 0.0 1.3e-70 238.0 0.0 2.1 1 1 0 1 1 1 1 Melibiase FAD_binding_8 PF08022.7 KOG98734.1 - 2.2e-27 94.9 0.0 4.9e-27 93.8 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 KOG98734.1 - 6.1e-27 94.4 0.0 9.1e-27 93.8 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 KOG98734.1 - 4.4e-20 72.0 14.2 4.4e-20 72.0 9.8 2.2 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 KOG98734.1 - 0.14 12.2 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain DUF4131 PF13567.1 KOG98734.1 - 4.4 6.6 8.1 7.9 5.8 4.8 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) Aldose_epim PF01263.15 KOG98735.1 - 2.2e-79 266.7 0.1 2.5e-79 266.5 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase ADH_zinc_N PF00107.21 KOG98736.1 - 2.4e-25 88.5 0.7 2.4e-25 88.5 0.5 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOG98736.1 - 2.3e-17 62.7 0.3 9.5e-17 60.7 0.0 2.2 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 KOG98736.1 - 5.2e-05 24.1 0.0 0.00012 22.9 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.9 KOG98736.1 - 0.0047 16.3 0.0 0.0098 15.2 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.22 KOG98736.1 - 0.02 15.2 0.1 0.13 12.6 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.14 KOG98736.1 - 0.099 11.7 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 KOG98736.1 - 0.12 12.0 0.2 0.23 11.1 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 KOG98736.1 - 0.12 11.3 0.5 0.18 10.7 0.4 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase Amidase PF01425.16 KOG98737.1 - 7.8e-70 235.9 0.0 4e-67 226.9 0.0 2.1 2 0 0 2 2 2 2 Amidase Asp PF00026.18 KOG98738.1 - 1.4e-57 195.3 7.3 1.7e-57 195.0 5.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOG98738.1 - 3.3e-10 40.1 1.1 8.4e-10 38.8 0.8 1.8 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 KOG98738.1 - 6.9e-07 29.6 0.4 0.32 11.5 0.0 3.5 3 0 0 3 3 3 3 Aspartyl protease TAXi_C PF14541.1 KOG98738.1 - 0.02 14.4 0.1 0.053 13.0 0.0 1.6 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Aldo_ket_red PF00248.16 KOG98739.1 - 9.8e-48 162.3 0.0 1.1e-47 162.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.11 KOG98740.1 - 3.7e-28 98.2 14.3 4.8e-28 97.8 9.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 KOG98740.1 - 0.0002 19.9 3.5 0.00066 18.1 2.2 2.1 1 1 1 2 2 2 1 MFS/sugar transport protein MFS_1_like PF12832.2 KOG98740.1 - 0.036 13.8 0.7 0.036 13.8 0.5 3.0 3 0 0 3 3 3 0 MFS_1 like family CN_hydrolase PF00795.17 KOG98741.1 - 5.7e-31 107.2 0.0 7.7e-31 106.8 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Glyco_hydro_32N PF00251.15 KOG98742.1 - 8.3e-89 297.9 13.4 1.2e-88 297.4 9.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.7 KOG98742.1 - 1.9e-09 37.7 0.2 9.1e-09 35.5 0.2 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 32 C terminal DUF1777 PF08648.7 KOG98743.1 - 0.0016 18.1 16.3 0.0021 17.8 11.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) Neur_chan_memb PF02932.11 KOG98743.1 - 0.44 10.3 4.9 0.51 10.1 3.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Corona_nucleoca PF00937.13 KOG98743.1 - 0.51 9.2 22.3 0.74 8.7 15.5 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein XAP5 PF04921.9 KOG98743.1 - 0.59 9.6 20.0 1 8.8 13.9 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator Ndc1_Nup PF09531.5 KOG98743.1 - 2.6 6.3 6.9 2.7 6.2 4.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DDHD PF02862.12 KOG98743.1 - 4.9 6.8 9.8 9.7 5.9 6.8 1.5 1 0 0 1 1 1 0 DDHD domain Thiolase_N PF00108.18 KOG98744.1 - 2.6e-88 295.4 0.0 3.5e-88 294.9 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 KOG98744.1 - 4.4e-50 168.2 0.3 8e-50 167.3 0.2 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 KOG98744.1 - 0.0027 17.2 0.6 0.0061 16.0 0.1 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain FH2 PF02181.18 KOG98745.1 - 3.2e-73 246.7 17.0 3.2e-73 246.7 11.8 2.3 2 0 0 2 2 2 1 Formin Homology 2 Domain SKG6 PF08693.5 KOG98746.1 - 0.00082 18.6 0.4 0.0022 17.2 0.2 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Coa1 PF08695.5 KOG98747.1 - 9.3e-38 128.3 0.0 1.3e-37 127.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 lci PF12197.3 KOG98747.1 - 0.24 10.9 1.5 1.1 8.8 0.2 2.1 2 0 0 2 2 2 0 Bacillus cereus group antimicrobial protein DUF1748 PF08520.5 KOG98748.1 - 1.8e-12 46.6 0.2 1.9e-12 46.6 0.1 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) UCH PF00443.24 KOG98749.1 - 3.2e-63 213.3 2.9 3.2e-63 213.3 2.0 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOG98749.1 - 5.2e-31 108.1 1.6 5.2e-31 108.1 1.1 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Jiraiya PF15038.1 KOG98749.1 - 0.063 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Jiraiya DAO PF01266.19 KOG98750.1 - 1.4e-54 185.3 0.0 2.1e-54 184.7 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOG98750.1 - 2.1e-13 49.9 1.8 2.3e-07 30.0 0.7 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.2 KOG98750.1 - 1.1e-10 41.2 0.0 3e-08 33.1 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOG98750.1 - 1.9e-06 27.9 0.3 0.00013 21.9 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 KOG98750.1 - 4.1e-05 22.6 3.9 0.0034 16.2 0.5 2.6 3 0 0 3 3 3 2 Glucose inhibited division protein A Thi4 PF01946.12 KOG98750.1 - 9.1e-05 21.6 0.3 0.042 12.9 0.0 2.3 2 0 0 2 2 2 2 Thi4 family HI0933_like PF03486.9 KOG98750.1 - 0.00018 20.1 0.7 0.0003 19.4 0.5 1.3 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.1 KOG98750.1 - 0.00019 21.3 0.7 0.00068 19.6 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 KOG98750.1 - 0.0037 16.2 0.8 0.062 12.2 0.1 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.14 KOG98750.1 - 0.0056 15.7 1.4 0.077 12.0 1.1 2.1 1 1 0 1 1 1 1 FAD binding domain GMC_oxred_N PF00732.14 KOG98750.1 - 0.018 14.2 0.1 0.063 12.4 0.0 1.8 2 0 0 2 2 2 0 GMC oxidoreductase 3HCDH_N PF02737.13 KOG98750.1 - 0.043 13.4 1.3 0.15 11.7 0.9 1.9 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.22 KOG98750.1 - 0.07 13.5 0.4 0.17 12.3 0.3 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Nop25 PF09805.4 KOG98751.1 - 0.061 13.3 7.6 0.11 12.5 5.3 1.4 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) COPI_C PF06957.6 KOG98751.1 - 0.14 10.7 2.3 0.17 10.3 1.6 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus Daxx PF03344.10 KOG98751.1 - 1.2 7.5 13.7 1.6 7.0 9.5 1.3 1 0 0 1 1 1 0 Daxx Family PTPA PF03095.10 KOG98752.1 - 9.5e-109 363.1 0.0 1.1e-108 362.9 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Tombus_P19 PF03220.8 KOG98753.1 - 0.013 14.8 0.2 0.02 14.2 0.2 1.2 1 0 0 1 1 1 0 Tombusvirus P19 core protein PIN_4 PF13638.1 KOG98754.1 - 1e-09 38.5 1.2 2.3e-09 37.4 0.8 1.6 1 0 0 1 1 1 1 PIN domain zf-primase PF09329.6 KOG98755.1 - 1.9e-14 52.9 1.4 3.5e-14 52.1 1.0 1.5 1 0 0 1 1 1 1 Primase zinc finger TPR_MLP1_2 PF07926.7 KOG98756.1 - 3e-10 39.9 20.0 3e-10 39.9 13.9 16.0 6 4 8 14 14 14 1 TPR/MLP1/MLP2-like protein ubiquitin PF00240.18 KOG98757.1 - 1.8e-34 116.9 0.9 2.3e-34 116.5 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.12 KOG98757.1 - 4.3e-31 106.2 10.9 6.7e-31 105.6 7.6 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.3 KOG98757.1 - 3.8e-18 64.9 0.3 6e-18 64.3 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 KOG98757.1 - 1.1e-05 25.5 0.1 4e-05 23.7 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 KOG98757.1 - 0.0015 18.2 0.0 0.0023 17.6 0.0 1.2 1 0 0 1 1 1 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 KOG98757.1 - 0.009 15.8 0.0 0.018 14.9 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 KOG98757.1 - 0.011 15.9 0.0 0.012 15.7 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Fer2_3 PF13085.1 KOG98757.1 - 0.25 11.1 1.5 1 9.1 0.8 2.0 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain zf-DHHC PF01529.15 KOG98757.1 - 8.4 5.7 10.3 2.8 7.3 2.4 2.1 2 0 0 2 2 2 0 DHHC palmitoyltransferase HATPase_c PF02518.21 KOG98758.1 - 2.9e-28 97.8 3.6 2e-27 95.1 2.5 2.3 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 KOG98758.1 - 9.5e-28 96.4 0.1 2.5e-27 95.0 0.1 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 KOG98758.1 - 9.8e-11 41.4 0.1 3e-10 39.9 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.20 KOG98758.1 - 0.016 15.3 10.7 0.21 11.8 0.2 3.1 3 0 0 3 3 3 0 HAMP domain DUF4449 PF14613.1 KOG98759.1 - 0.00057 19.8 1.3 0.001 19.0 0.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4449) RNase_H2-Ydr279 PF09468.5 KOG98759.1 - 0.014 14.6 5.8 0.025 13.7 4.0 1.4 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Iron_permease PF04120.7 KOG98759.1 - 0.11 12.0 0.3 0.21 11.1 0.2 1.4 1 0 0 1 1 1 0 Low affinity iron permease 7tm_6 PF02949.15 KOG98759.1 - 0.35 9.6 1.6 0.85 8.4 0.0 2.1 2 1 1 3 3 3 0 7tm Odorant receptor NUC153 PF08159.7 KOG98759.1 - 0.61 9.7 2.7 0.7 9.5 0.1 2.4 3 0 0 3 3 3 0 NUC153 domain Med19 PF10278.4 KOG98759.1 - 1.3 8.6 9.1 2.4 7.8 6.3 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Pantoate_ligase PF02569.10 KOG98760.1 - 6e-118 392.6 0.1 6.7e-118 392.4 0.1 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Ndc80_HEC PF03801.8 KOG98761.1 - 3.1e-57 192.4 1.6 3.1e-57 192.4 1.1 2.4 1 1 1 2 2 2 1 HEC/Ndc80p family CENP-F_leu_zip PF10473.4 KOG98761.1 - 0.00012 21.9 14.8 0.00012 21.9 10.3 3.6 2 2 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YqbF PF14553.1 KOG98761.1 - 0.017 14.7 1.7 1.2 8.8 0.3 3.3 2 0 0 2 2 2 0 YqbF, hypothetical protein domain Filament PF00038.16 KOG98761.1 - 0.032 13.7 39.5 0.054 12.9 12.3 2.6 2 0 0 2 2 2 0 Intermediate filament protein MbeD_MobD PF04899.7 KOG98761.1 - 0.56 10.1 6.7 0.88 9.5 0.1 3.5 3 0 0 3 3 3 0 MbeD/MobD like Helicase_C_3 PF13625.1 KOG98762.1 - 1.7e-25 89.2 0.0 5.6e-25 87.5 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOG98762.1 - 5.5e-14 52.4 0.0 1.2e-13 51.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KOG98762.1 - 2.7e-12 46.1 0.1 4.2e-12 45.4 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOG98762.1 - 1.4e-10 40.8 0.0 3.3e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOG98762.1 - 3e-07 30.0 0.0 6.1e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SBP_bac_6 PF13343.1 KOG98762.1 - 0.033 13.5 0.1 0.33 10.2 0.0 2.2 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein AAA_34 PF13872.1 KOG98762.1 - 0.057 12.1 0.0 0.1 11.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 Cpn60_TCP1 PF00118.19 KOG98763.1 - 1.7e-136 455.7 11.8 2e-136 455.4 8.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Transposase_23 PF03017.9 KOG98763.1 - 0.017 14.6 0.1 0.061 12.8 0.0 2.0 2 0 0 2 2 2 0 TNP1/EN/SPM transposase SKG6 PF08693.5 KOG98764.1 - 8.2e-16 57.0 1.6 1.8e-15 55.9 1.1 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain He_PIG PF05345.7 KOG98764.1 - 9.9e-12 44.7 4.1 4.8e-05 23.3 0.0 5.1 4 1 0 4 4 4 2 Putative Ig domain TMEM154 PF15102.1 KOG98764.1 - 6.4e-06 25.9 1.4 2.4e-05 24.0 1.0 2.0 1 0 0 1 1 1 1 TMEM154 protein family Rifin_STEVOR PF02009.11 KOG98764.1 - 2.3e-05 24.2 0.2 4.3e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 Rifin/stevor family Mid2 PF04478.7 KOG98764.1 - 0.00031 20.1 5.0 0.00031 20.1 3.5 2.2 2 1 0 2 2 2 1 Mid2 like cell wall stress sensor Adeno_E3_CR2 PF02439.10 KOG98764.1 - 0.0018 17.7 0.2 0.0032 16.9 0.1 1.3 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Herpes_gE PF02480.11 KOG98764.1 - 0.0055 15.0 0.1 0.01 14.1 0.1 1.4 1 1 0 1 1 1 1 Alphaherpesvirus glycoprotein E DUF912 PF06024.7 KOG98764.1 - 0.04 13.9 0.4 0.04 13.9 0.3 2.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) EphA2_TM PF14575.1 KOG98764.1 - 0.11 12.9 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MGC-24 PF05283.6 KOG98764.1 - 0.82 9.4 16.6 0.013 15.2 4.8 2.4 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24) HORMA PF02301.13 KOG98765.1 - 8.2e-23 80.9 3.6 1e-22 80.6 2.5 1.1 1 0 0 1 1 1 1 HORMA domain Tropomyosin_1 PF12718.2 KOG98766.1 - 3.3e-42 143.7 40.1 4e-42 143.4 27.8 1.1 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.15 KOG98766.1 - 1.4e-08 34.1 37.0 0.00021 20.4 10.6 2.1 1 1 1 2 2 2 2 Tropomyosin GAS PF13851.1 KOG98766.1 - 0.00016 20.9 35.2 0.0082 15.3 13.0 2.3 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding APG6 PF04111.7 KOG98766.1 - 0.0003 19.9 40.1 0.034 13.2 12.8 2.0 1 1 1 2 2 2 2 Autophagy protein Apg6 TMF_DNA_bd PF12329.3 KOG98766.1 - 0.00033 20.4 43.2 0.0066 16.2 11.0 3.2 2 1 1 3 3 3 2 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.4 KOG98766.1 - 0.00059 19.7 40.9 0.016 15.0 7.1 2.3 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TelA PF05816.6 KOG98766.1 - 0.0017 17.1 3.1 0.0017 17.1 2.1 2.1 1 1 1 2 2 2 1 Toxic anion resistance protein (TelA) KLRAQ PF10205.4 KOG98766.1 - 0.0019 18.2 10.8 0.0019 18.2 7.5 2.2 1 1 1 2 2 2 1 Predicted coiled-coil domain-containing protein WXG100 PF06013.7 KOG98766.1 - 0.0027 17.6 16.1 0.057 13.4 0.1 3.7 2 1 1 3 3 3 2 Proteins of 100 residues with WXG Laminin_II PF06009.7 KOG98766.1 - 0.0043 16.8 8.8 0.0043 16.8 6.1 2.4 1 1 1 2 2 2 1 Laminin Domain II Filament PF00038.16 KOG98766.1 - 0.0046 16.4 30.8 0.016 14.6 9.2 2.0 1 1 1 2 2 2 1 Intermediate filament protein ERM PF00769.14 KOG98766.1 - 0.0053 16.3 37.0 0.026 14.0 15.4 2.1 1 1 1 2 2 2 1 Ezrin/radixin/moesin family ADIP PF11559.3 KOG98766.1 - 0.0088 15.9 32.9 0.36 10.7 12.5 2.8 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding DUF3584 PF12128.3 KOG98766.1 - 0.017 12.4 31.2 0.019 12.3 21.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Uds1 PF15456.1 KOG98766.1 - 0.025 14.5 26.5 0.021 14.8 7.0 2.6 1 1 1 2 2 2 0 Up-regulated During Septation MIS13 PF08202.6 KOG98766.1 - 0.025 13.6 28.3 1.2 8.1 13.3 2.3 1 1 1 2 2 2 0 Mis12-Mtw1 protein family BLOC1_2 PF10046.4 KOG98766.1 - 0.028 14.5 28.2 0.57 10.3 4.9 3.5 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlaC_arch PF05377.6 KOG98766.1 - 0.036 13.9 21.1 2.7 7.9 1.4 4.2 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) Lectin_N PF03954.9 KOG98766.1 - 0.049 13.0 12.4 0.041 13.2 3.7 2.2 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain HAP1_N PF04849.8 KOG98766.1 - 0.053 12.4 33.7 0.062 12.2 23.4 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region PEPcase PF00311.12 KOG98766.1 - 0.053 11.3 11.5 0.053 11.3 8.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase ATG16 PF08614.6 KOG98766.1 - 0.067 13.0 31.1 0.17 11.6 8.5 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Imm15 PF15590.1 KOG98766.1 - 0.067 12.2 1.8 2.4 7.3 0.1 2.6 2 0 0 2 2 2 0 Immunity protein 15 AAA_13 PF13166.1 KOG98766.1 - 0.071 11.5 29.2 0.084 11.3 20.2 1.1 1 0 0 1 1 1 0 AAA domain EzrA PF06160.7 KOG98766.1 - 0.092 10.9 27.4 0.61 8.2 19.0 2.0 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Fib_alpha PF08702.5 KOG98766.1 - 0.097 12.7 20.9 0.32 11.1 8.4 2.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Nup54 PF13874.1 KOG98766.1 - 0.12 12.0 19.4 0.097 12.3 9.8 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Cortex-I_coil PF09304.5 KOG98766.1 - 0.15 12.1 31.0 0.25 11.3 8.9 3.0 1 1 2 3 3 3 0 Cortexillin I, coiled coil SNARE PF05739.14 KOG98766.1 - 0.17 11.6 9.8 2 8.1 0.2 3.7 4 0 0 4 4 3 0 SNARE domain Mod_r PF07200.8 KOG98766.1 - 0.18 11.7 32.4 0.22 11.4 16.7 2.8 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Reo_sigmaC PF04582.7 KOG98766.1 - 0.21 10.7 4.3 2.5 7.1 0.5 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Ax_dynein_light PF10211.4 KOG98766.1 - 0.23 11.3 36.2 0.55 10.0 6.9 3.1 1 1 2 3 3 3 0 Axonemal dynein light chain TBPIP PF07106.8 KOG98766.1 - 0.37 10.3 33.3 2.4 7.6 10.3 2.4 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TACC PF05010.9 KOG98766.1 - 0.39 10.4 28.5 2.2 7.9 1.9 2.1 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC) Spc7 PF08317.6 KOG98766.1 - 0.42 9.2 32.5 0.52 8.9 10.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Lebercilin PF15619.1 KOG98766.1 - 0.46 9.8 35.1 2.2 7.6 10.8 2.1 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Taxilin PF09728.4 KOG98766.1 - 0.55 9.2 35.1 0.11 11.5 6.8 2.6 1 1 1 2 2 2 0 Myosin-like coiled-coil protein IncA PF04156.9 KOG98766.1 - 0.57 9.7 37.9 1.6e+02 1.7 26.0 2.3 1 1 0 1 1 1 0 IncA protein Mnd1 PF03962.10 KOG98766.1 - 0.68 9.5 33.6 2.9 7.4 10.5 2.1 1 1 1 2 2 2 0 Mnd1 family HlyD PF00529.15 KOG98766.1 - 0.8 8.9 16.7 6.8 5.9 11.6 1.9 1 1 0 1 1 1 0 HlyD family secretion protein NPV_P10 PF05531.7 KOG98766.1 - 0.8 10.0 12.0 3.3e+03 -1.6 8.3 3.9 1 1 0 1 1 0 0 Nucleopolyhedrovirus P10 protein Atg14 PF10186.4 KOG98766.1 - 0.8 8.5 27.7 0.48 9.3 7.3 2.0 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 MbeD_MobD PF04899.7 KOG98766.1 - 0.83 9.5 13.7 0.32 10.9 0.6 3.2 1 1 2 3 3 3 0 MbeD/MobD like Fez1 PF06818.10 KOG98766.1 - 0.85 9.5 26.5 1 9.3 18.3 1.1 1 0 0 1 1 1 0 Fez1 DUF4200 PF13863.1 KOG98766.1 - 0.91 9.4 39.1 2.9 7.8 12.9 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF972 PF06156.8 KOG98766.1 - 1 9.7 30.6 1.5e+04 -5.4 21.2 2.7 1 1 0 1 1 0 0 Protein of unknown function (DUF972) DUF3450 PF11932.3 KOG98766.1 - 1 8.5 26.3 0.85 8.8 6.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) FliD_C PF07195.7 KOG98766.1 - 1 8.5 20.4 5.7 6.1 0.3 3.1 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Seryl_tRNA_N PF02403.17 KOG98766.1 - 1.1 9.3 32.1 1.1 9.3 2.2 3.2 1 1 1 2 2 1 0 Seryl-tRNA synthetase N-terminal domain WEMBL PF05701.6 KOG98766.1 - 1.2 7.4 34.0 0.34 9.3 10.8 2.0 1 1 1 2 2 2 0 Weak chloroplast movement under blue light DUF812 PF05667.6 KOG98766.1 - 1.2 7.5 28.7 1.7 7.0 6.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) BBP1_C PF15272.1 KOG98766.1 - 1.3 8.5 30.5 1.2 8.6 2.8 3.0 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal DUF869 PF05911.6 KOG98766.1 - 1.3 7.1 33.8 0.21 9.7 17.3 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) TPR_MLP1_2 PF07926.7 KOG98766.1 - 1.4 8.6 39.1 0.42 10.3 13.3 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Syntaxin-6_N PF09177.6 KOG98766.1 - 1.4 9.3 24.0 2.5 8.5 1.3 3.1 1 1 2 3 3 3 0 Syntaxin 6, N-terminal Sec2p PF06428.6 KOG98766.1 - 1.5 8.7 30.0 0.53 10.1 11.6 3.3 1 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p IFT57 PF10498.4 KOG98766.1 - 1.5 7.4 28.8 2.9 6.5 10.7 2.1 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DivIC PF04977.10 KOG98766.1 - 1.6 8.2 32.8 0.084 12.3 3.8 4.1 1 1 3 4 4 4 0 Septum formation initiator RPW8 PF05659.6 KOG98766.1 - 1.7 8.1 8.6 1.1 8.8 3.2 2.4 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Prefoldin_2 PF01920.15 KOG98766.1 - 1.7 8.4 40.5 3.8 7.3 2.8 4.1 1 1 3 4 4 4 0 Prefoldin subunit Rootletin PF15035.1 KOG98766.1 - 1.8 8.4 32.7 6.3 6.7 10.3 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion FliJ PF02050.11 KOG98766.1 - 2 8.4 31.1 2.9 7.9 11.2 3.0 1 1 1 2 2 2 0 Flagellar FliJ protein Laminin_I PF06008.9 KOG98766.1 - 2.2 7.5 30.2 0.59 9.4 16.6 2.1 1 1 1 2 2 2 0 Laminin Domain I AATF-Che1 PF13339.1 KOG98766.1 - 2.2 8.4 24.4 2.3 8.3 0.4 2.6 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor FTO_CTD PF12934.2 KOG98766.1 - 2.2 7.8 14.0 1.3 8.5 2.4 2.2 1 1 1 2 2 2 0 FTO C-terminal domain T2SM PF04612.7 KOG98766.1 - 2.5 7.8 11.9 2.6 7.8 1.8 3.0 2 1 1 3 3 3 0 Type II secretion system (T2SS), protein M G6PD_N PF00479.17 KOG98766.1 - 2.5 8.2 8.8 0.21 11.7 0.7 2.3 1 1 1 2 2 2 0 Glucose-6-phosphate dehydrogenase, NAD binding domain STAT_alpha PF01017.15 KOG98766.1 - 2.5 7.7 21.8 14 5.3 15.1 2.0 1 1 0 1 1 1 0 STAT protein, all-alpha domain DUF1664 PF07889.7 KOG98766.1 - 2.7 7.7 16.3 6.5 6.5 0.2 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) HSP70 PF00012.15 KOG98766.1 - 2.8 5.7 22.7 3.3 5.5 15.7 1.2 1 0 0 1 1 1 0 Hsp70 protein IZUMO PF15005.1 KOG98766.1 - 3.1 7.8 10.2 1.3 9.0 4.8 1.8 1 1 1 2 2 2 0 Izumo sperm-egg fusion Baculo_PEP_C PF04513.7 KOG98766.1 - 3.5 7.4 9.9 1.2e+02 2.4 6.8 2.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Vps5 PF09325.5 KOG98766.1 - 3.8 6.6 26.6 0.19 10.9 5.7 2.9 1 1 2 3 3 3 0 Vps5 C terminal like PspA_IM30 PF04012.7 KOG98766.1 - 4.1 6.7 27.4 3.3 7.0 7.0 2.6 1 1 1 2 2 2 0 PspA/IM30 family PMC2NT PF08066.7 KOG98766.1 - 4.4 7.6 11.5 0.78 10.0 4.2 2.1 1 1 1 2 2 2 0 PMC2NT (NUC016) domain DivIVA PF05103.8 KOG98766.1 - 4.7 7.2 32.0 35 4.4 10.1 3.2 1 1 1 2 2 2 0 DivIVA protein CALCOCO1 PF07888.6 KOG98766.1 - 6.7 4.8 26.5 39 2.3 18.4 1.8 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like MAD PF05557.8 KOG98766.1 - 7.5 4.5 35.3 3.2 5.7 3.7 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF724 PF05266.9 KOG98766.1 - 9.1 5.8 33.0 4.9 6.7 9.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF2802 PF10975.3 KOG98766.1 - 9.9 6.0 16.4 33 4.3 0.9 4.4 1 1 3 4 4 4 0 Protein of unknown function (DUF2802) Peptidase_M1 PF01433.15 KOG98767.1 - 1.2e-104 350.4 1.5 1.2e-104 350.4 1.0 1.6 2 0 0 2 2 2 1 Peptidase family M1 ERAP1_C PF11838.3 KOG98767.1 - 2.8e-72 243.7 0.0 4.1e-72 243.1 0.0 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 KOG98767.1 - 1.4e-13 51.0 0.0 2.7e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily peroxidase PF00141.18 KOG98767.1 - 0.016 14.7 0.0 0.035 13.5 0.0 1.5 1 0 0 1 1 1 0 Peroxidase DUF2265 PF10023.4 KOG98767.1 - 0.019 14.1 0.0 0.033 13.3 0.0 1.3 1 0 0 1 1 1 0 Predicted aminopeptidase (DUF2265) PGA_cap PF09587.5 KOG98767.1 - 0.029 13.7 0.0 2 7.6 0.0 2.6 2 0 0 2 2 2 0 Bacterial capsule synthesis protein PGA_cap MIT PF04212.13 KOG98768.1 - 0.55 10.1 7.4 0.27 11.1 0.7 3.3 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.12 KOG98768.1 - 2.4 8.2 7.3 7.7 6.7 1.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Mito_carr PF00153.22 KOG98770.1 - 1.7e-63 210.3 2.0 3.6e-22 77.8 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L13 PF00572.13 KOG98771.1 - 0.006 16.6 0.2 0.012 15.6 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L13 Fork_head PF00250.13 KOG98773.1 - 8e-36 121.9 0.5 1.8e-35 120.8 0.3 1.6 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 KOG98773.1 - 3.3e-13 49.5 0.1 3.8e-12 46.1 0.0 2.5 2 0 0 2 2 2 1 FHA domain Linker_histone PF00538.14 KOG98773.1 - 0.09 12.8 0.0 0.41 10.7 0.0 2.1 2 0 0 2 2 2 0 linker histone H1 and H5 family Fungal_trans PF04082.13 KOG98774.1 - 1.1e-37 129.3 2.7 1.1e-37 129.3 1.9 2.7 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG98774.1 - 5.9e-11 42.0 12.8 1e-10 41.3 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MOR2-PAG1_N PF14222.1 KOG98775.1 - 3.1e-186 620.3 11.5 7.9e-186 618.9 8.0 1.8 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.1 KOG98775.1 - 3.8e-97 325.1 1.4 3.8e-97 325.1 0.9 4.1 5 1 1 6 6 6 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.1 KOG98775.1 - 4.2e-22 77.6 18.0 9.6e-11 40.0 0.8 3.7 2 2 1 3 3 3 3 Cell morphogenesis central region MMS19_C PF12460.3 KOG98776.1 - 1.8e-92 310.2 24.6 1.8e-92 310.2 17.1 3.2 3 1 1 4 4 4 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.1 KOG98776.1 - 1.7e-90 302.8 18.5 6.7e-89 297.6 4.4 4.3 4 1 1 5 5 5 3 Dos2-interacting transcription regulator of RNA-Pol-II HEAT PF02985.17 KOG98776.1 - 1.9e-07 30.5 0.7 0.021 14.8 0.0 5.5 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.1 KOG98776.1 - 4.3e-07 30.1 0.1 0.00011 22.3 0.0 3.6 3 0 0 3 3 3 1 HEAT repeats HEAT_EZ PF13513.1 KOG98776.1 - 0.00056 20.3 4.5 0.37 11.3 0.0 4.9 4 1 0 4 4 4 1 HEAT-like repeat Vac14_Fab1_bd PF12755.2 KOG98776.1 - 0.004 17.4 0.5 0.62 10.4 0.0 4.1 2 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region SpoU_sub_bind PF08032.7 KOG98777.1 - 0.039 14.1 2.1 0.039 14.1 1.5 2.1 2 1 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding Asp-B-Hydro_N PF05279.6 KOG98777.1 - 2.7 7.7 11.7 4 7.2 8.1 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DnaG_DnaB_bind PF08278.6 KOG98777.1 - 3.9 7.6 9.0 9.1 6.5 5.1 2.3 1 1 1 2 2 2 0 DNA primase DnaG DnaB-binding SNF2_N PF00176.18 KOG98778.1 - 5.6e-85 284.7 1.1 5.6e-85 284.7 0.8 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOG98778.1 - 9.5e-20 70.2 0.1 5.4e-18 64.6 0.0 3.7 4 0 0 4 4 4 1 Helicase conserved C-terminal domain Bromodomain PF00439.20 KOG98778.1 - 1.9e-19 69.3 1.4 6.4e-19 67.6 0.2 2.6 2 0 0 2 2 2 1 Bromodomain SnAC PF14619.1 KOG98778.1 - 7.1e-14 51.7 1.2 7.1e-14 51.7 0.8 3.8 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex Transket_pyr PF02779.19 KOG98779.1 - 5.3e-66 221.4 0.0 1.1e-65 220.4 0.0 1.6 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 KOG98779.1 - 2.9e-55 187.1 0.0 3.8e-55 186.7 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component LuxE PF04443.7 KOG98779.1 - 0.15 10.6 0.5 0.26 9.9 0.3 1.3 1 0 0 1 1 1 0 Acyl-protein synthetase, LuxE adh_short PF00106.20 KOG98780.1 - 1.8e-26 93.0 0.0 2.8e-26 92.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOG98780.1 - 8.6e-13 48.6 0.0 1.2e-12 48.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 KOG98780.1 - 1.8e-06 28.0 0.0 4e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOG98780.1 - 2.3e-06 27.2 0.0 1e-05 25.1 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.5 KOG98780.1 - 8e-06 25.6 0.0 1.2e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.12 KOG98780.1 - 7.3e-05 21.7 0.0 9.7e-05 21.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.8 KOG98780.1 - 0.011 15.0 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family DUF1776 PF08643.5 KOG98780.1 - 0.019 14.1 0.0 5.4 6.0 0.0 2.9 3 0 0 3 3 3 0 Fungal family of unknown function (DUF1776) Saccharop_dh PF03435.13 KOG98780.1 - 0.019 13.9 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase 3Beta_HSD PF01073.14 KOG98780.1 - 0.067 11.8 0.0 0.096 11.3 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family SUN PF03856.8 KOG98781.1 - 4.8e-106 353.6 14.9 7.6e-106 352.9 10.3 1.3 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) TFIIA PF03153.8 KOG98781.1 - 7.9 6.2 14.0 11 5.8 9.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MFS_1 PF07690.11 KOG98783.1 - 6e-43 146.8 18.8 4.1e-37 127.7 9.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Peptidase_M9_N PF08453.5 KOG98783.1 - 0.13 11.5 0.0 0.29 10.4 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M9 N-terminal Gly-zipper_Omp PF13488.1 KOG98783.1 - 0.35 10.5 3.1 0.87 9.2 2.2 1.6 1 0 0 1 1 1 0 Glycine zipper MFS_1 PF07690.11 KOG98784.1 - 1.7e-43 148.7 22.2 9.9e-40 136.3 9.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 KOG98784.1 - 1.7e-12 46.6 14.9 1.7e-12 46.6 10.3 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 KOG98784.1 - 8.9e-06 24.1 5.0 8.9e-06 24.1 3.5 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) ESSS PF10183.4 KOG98784.1 - 0.16 12.3 0.1 0.71 10.3 0.1 2.0 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Myb_DNA-bind_4 PF13837.1 KOG98785.1 - 5.2e-06 26.5 7.2 1.2e-05 25.3 1.8 2.7 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Ras PF00071.17 KOG98786.1 - 2e-59 199.6 0.1 2.5e-59 199.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG98786.1 - 5.6e-16 59.1 0.0 8.6e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOG98786.1 - 3.8e-10 39.2 0.0 5.9e-10 38.6 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOG98786.1 - 0.00039 19.6 0.0 0.00049 19.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.15 KOG98786.1 - 0.0014 17.4 0.0 0.0016 17.1 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit MMR_HSR1 PF01926.18 KOG98786.1 - 0.0022 17.9 0.1 0.0032 17.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KOG98786.1 - 0.0025 17.0 0.0 0.0033 16.6 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arch_ATPase PF01637.13 KOG98786.1 - 0.029 14.0 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase ABC_tran PF00005.22 KOG98786.1 - 0.037 14.3 0.3 0.079 13.2 0.2 1.8 1 1 0 1 1 1 0 ABC transporter MIG-14_Wnt-bd PF06664.7 KOG98787.1 - 0.057 12.2 0.0 0.087 11.6 0.0 1.2 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion EphA2_TM PF14575.1 KOG98787.1 - 0.1 13.0 0.0 0.36 11.2 0.0 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF2189 PF09955.4 KOG98787.1 - 0.24 11.3 4.0 0.56 10.1 2.8 1.6 1 1 0 1 1 1 0 Predicted integral membrane protein (DUF2189) DUF3139 PF11337.3 KOG98787.1 - 0.26 11.5 1.7 0.7 10.2 1.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3139) DctM PF06808.7 KOG98787.1 - 0.53 8.7 9.3 0.68 8.4 6.4 1.1 1 0 0 1 1 1 0 DctM-like transporters MSP1_C PF07462.6 KOG98787.1 - 5.3 5.3 10.9 10 4.3 7.6 1.4 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Aminotran_1_2 PF00155.16 KOG98788.1 - 5.4e-70 236.1 0.0 6.4e-70 235.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.8 KOG98788.1 - 0.00089 18.0 0.0 0.0013 17.4 0.0 1.3 1 0 0 1 1 1 1 Allinase Porin_3 PF01459.17 KOG98790.1 - 2.3e-50 171.4 2.7 2.6e-50 171.2 1.9 1.0 1 0 0 1 1 1 1 Eukaryotic porin DSPc PF00782.15 KOG98791.1 - 9.2e-33 112.6 0.0 1.1e-32 112.3 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOG98791.1 - 0.00014 21.2 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.7 KOG98791.1 - 0.016 14.6 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.1 KOG98791.1 - 0.043 13.8 0.0 0.066 13.2 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Init_tRNA_PT PF04179.7 KOG98791.1 - 0.15 10.8 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase Ank_2 PF12796.2 KOG98792.1 - 1.3e-50 169.6 1.1 1.3e-24 86.3 0.1 3.7 2 2 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOG98792.1 - 4.2e-36 120.9 0.3 1.6e-10 40.2 0.1 6.5 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.1 KOG98792.1 - 5.1e-31 105.9 0.0 2.7e-08 33.7 0.0 4.8 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOG98792.1 - 6.2e-29 99.8 0.0 1.4e-11 44.5 0.0 4.5 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOG98792.1 - 1.8e-27 92.6 0.0 5.8e-09 35.3 0.1 5.1 4 0 0 4 4 4 4 Ankyrin repeat DUF1110 PF06533.7 KOG98792.1 - 0.039 13.7 0.2 8.8 6.0 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1110) Sec23_trunk PF04811.10 KOG98794.1 - 2.8e-74 249.5 0.0 6.2e-74 248.4 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 KOG98794.1 - 7e-25 86.4 0.9 1.5e-24 85.3 0.2 2.0 2 0 0 2 2 2 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.10 KOG98794.1 - 3.1e-18 65.0 5.7 5.5e-18 64.2 4.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.7 KOG98794.1 - 1.1e-14 54.7 0.2 2.7e-14 53.4 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 KOG98794.1 - 5.8e-11 41.9 0.0 1.4e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Metallopep PF12044.3 KOG98795.1 - 1.2e-177 590.6 0.0 1.4e-177 590.4 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.12 KOG98795.1 - 1.3e-06 28.3 0.3 6.2e-06 26.1 0.0 2.4 2 1 0 2 2 2 1 Jacalin-like lectin domain Reprolysin_3 PF13582.1 KOG98795.1 - 0.014 15.9 0.0 0.034 14.6 0.0 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 KOG98795.1 - 0.029 14.3 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_4 PF13583.1 KOG98795.1 - 0.062 12.8 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like 6PF2K PF01591.13 KOG98796.1 - 2.8e-85 284.9 0.0 5.6e-85 283.9 0.0 1.5 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 KOG98796.1 - 1.3e-29 103.3 0.0 1.5e-28 99.8 0.0 2.3 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 KOG98796.1 - 2.5e-09 37.1 0.0 1.1e-08 35.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KOG98796.1 - 1.3e-06 29.2 0.1 7.2e-06 26.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KOG98796.1 - 0.012 15.9 0.0 0.088 13.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.15 KOG98796.1 - 0.028 14.0 0.0 0.063 12.9 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase Zeta_toxin PF06414.7 KOG98796.1 - 0.036 13.1 0.0 0.074 12.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Mob1_phocein PF03637.12 KOG98797.1 - 7.9e-76 253.5 0.1 9.5e-76 253.3 0.1 1.1 1 0 0 1 1 1 1 Mob1/phocein family PH PF00169.24 KOG98798.1 - 3.5e-16 59.3 0.3 1e-15 57.8 0.2 1.9 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 KOG98798.1 - 0.035 14.3 0.8 0.17 12.1 0.1 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain SHQ1 PF04925.10 KOG98799.1 - 2.5e-74 248.8 0.7 3.6e-74 248.3 0.5 1.2 1 0 0 1 1 1 1 SHQ1 protein Diphthamide_syn PF01866.12 KOG98800.1 - 5.4e-112 374.0 0.0 8.1e-112 373.4 0.0 1.3 1 0 0 1 1 1 1 Putative diphthamide synthesis protein DPM2 PF07297.7 KOG98801.1 - 9.5e-10 38.6 1.2 1.2e-09 38.3 0.8 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) COX3 PF00510.13 KOG98801.1 - 0.062 12.7 0.8 0.07 12.5 0.6 1.0 1 0 0 1 1 1 0 Cytochrome c oxidase subunit III DPM3 PF08285.6 KOG98801.1 - 0.44 10.4 1.9 0.59 10.0 1.3 1.3 1 1 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) RhodobacterPufX PF11511.3 KOG98801.1 - 2.5 7.5 4.5 3.3 7.1 0.0 2.1 2 0 0 2 2 2 0 Intrinsic membrane protein PufX Glyco_hydro_15 PF00723.16 KOG98803.1 - 6.1e-53 179.9 0.0 8.3e-53 179.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Complex1_LYR_2 PF13233.1 KOG98804.1 - 2.9e-17 63.0 0.7 4.2e-17 62.5 0.5 1.2 1 0 0 1 1 1 1 Complex1_LYR-like DnaG_DnaB_bind PF08278.6 KOG98804.1 - 0.077 13.2 0.6 0.22 11.7 0.1 1.8 1 1 1 2 2 2 0 DNA primase DnaG DnaB-binding CLTH PF10607.4 KOG98805.1 - 8.2e-33 113.1 2.1 8.2e-33 113.1 1.5 2.8 3 0 0 3 3 3 1 CTLH/CRA C-terminal to LisH motif domain U-box PF04564.10 KOG98805.1 - 0.006 16.5 0.2 0.045 13.7 0.0 2.6 2 0 0 2 2 2 1 U-box domain LOH1CR12 PF10158.4 KOG98805.1 - 0.085 12.6 2.4 0.23 11.2 0.9 2.0 2 0 0 2 2 2 0 Tumour suppressor protein DUF2431 PF10354.4 KOG98806.1 - 6.1e-55 185.6 0.6 6.1e-55 185.6 0.4 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2431) Pkinase PF00069.20 KOG98807.1 - 1.7e-36 125.6 0.0 3.2e-36 124.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98807.1 - 6.2e-31 107.4 0.0 9.7e-31 106.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG98807.1 - 2.6e-05 23.3 0.0 5e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOG98807.1 - 0.1 12.2 0.0 0.62 9.7 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Iso_dh PF00180.15 KOG98808.1 - 1.5e-112 376.0 0.0 1.8e-112 375.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase MRP-S25 PF13741.1 KOG98809.1 - 1.6e-90 302.6 2.4 1.8e-90 302.4 1.6 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.4 KOG98809.1 - 1.1e-05 25.2 0.8 0.00068 19.5 0.0 2.7 2 1 0 2 2 2 2 Mitochondrial ribosomal protein S23 DUF1253 PF06862.7 KOG98811.1 - 6.1e-164 545.6 11.5 9e-164 545.0 7.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1253) ICE2 PF08426.5 KOG98812.1 - 7.2e-174 578.2 21.9 8.3e-174 578.0 15.2 1.0 1 0 0 1 1 1 1 ICE2 Aa_trans PF01490.13 KOG98814.1 - 1e-137 459.0 18.3 1.2e-137 458.8 12.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2416 PF10315.4 KOG98815.1 - 3.7e-40 136.5 2.0 7.1e-40 135.6 1.4 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2416) Glyco_transf_15 PF01793.11 KOG98816.1 - 5.2e-125 416.7 13.4 7.4e-125 416.2 9.3 1.2 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Sds3 PF08598.6 KOG98817.1 - 3.6e-67 225.8 9.2 6.4e-67 225.0 6.4 1.4 1 1 0 1 1 1 1 Sds3-like Tim44 PF04280.10 KOG98817.1 - 0.0057 16.6 0.1 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 Tim44-like domain zf-CCHC PF00098.18 KOG98818.1 - 3.3e-09 36.2 39.8 0.00054 19.7 3.3 5.2 5 1 0 5 5 5 3 Zinc knuckle zf-CCHC_4 PF14392.1 KOG98818.1 - 0.012 15.2 33.5 0.29 10.8 1.1 5.4 4 1 1 5 5 5 0 Zinc knuckle tRNA-synt_2b PF00587.20 KOG98819.1 - 1.2e-46 158.4 0.4 2.4e-46 157.4 0.3 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KOG98819.1 - 2.1e-22 78.8 0.9 4.4e-22 77.8 0.6 1.6 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.16 KOG98819.1 - 3.6e-15 55.5 0.0 9.9e-15 54.1 0.0 1.7 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.9 KOG98819.1 - 6.9e-13 48.2 0.0 1.3e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF1689 PF07954.6 KOG98820.1 - 6.5e-57 191.6 1.2 8.6e-57 191.2 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1689) NAD_binding_10 PF13460.1 KOG98821.1 - 2.6e-26 92.7 0.1 3e-26 92.5 0.1 1.0 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 KOG98821.1 - 6.9e-11 41.8 0.0 1.3e-10 40.9 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.14 KOG98821.1 - 2.3e-08 33.0 0.4 3.4e-08 32.5 0.3 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 KOG98821.1 - 4.1e-07 29.6 0.1 1.2e-06 28.1 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 KOG98821.1 - 3e-06 27.5 0.1 9.2e-06 25.9 0.1 1.7 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 KOG98821.1 - 9e-06 25.6 0.1 1.7e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Ldh_1_N PF00056.18 KOG98821.1 - 0.00019 21.2 0.4 0.00027 20.7 0.2 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Coatomer_E PF04733.9 KOG98822.1 - 6.2e-11 42.0 12.5 1.6e-10 40.6 8.6 1.6 1 1 0 1 1 1 1 Coatomer epsilon subunit Imm16 PF15565.1 KOG98822.1 - 0.0097 15.7 0.2 0.033 14.0 0.0 2.0 2 0 0 2 2 2 1 Immunity protein 16 Apc3 PF12895.2 KOG98822.1 - 3 8.0 6.7 4.8 7.3 0.6 3.2 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 PC_rep PF01851.17 KOG98823.1 - 3.8e-41 137.0 27.7 2.4e-06 27.4 0.0 11.2 11 1 1 12 12 12 8 Proteasome/cyclosome repeat HEAT_2 PF13646.1 KOG98823.1 - 6.3e-16 58.4 8.1 3.6e-13 49.5 0.1 4.7 4 1 1 5 5 5 1 HEAT repeats HEAT PF02985.17 KOG98823.1 - 5.7e-08 32.1 3.0 0.55 10.4 0.1 4.8 4 0 0 4 4 4 3 HEAT repeat HEAT_EZ PF13513.1 KOG98823.1 - 8.9e-08 32.3 7.6 0.041 14.3 0.1 5.7 4 2 2 6 6 6 2 HEAT-like repeat Apc3 PF12895.2 KOG98823.1 - 0.013 15.6 0.2 3.1 8.0 0.1 3.7 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 RICTOR_V PF14668.1 KOG98823.1 - 0.033 14.1 0.2 0.23 11.3 0.0 2.6 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 Ribosomal_60s PF00428.14 KOG98823.1 - 0.047 14.0 10.4 0.14 12.5 7.2 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein Vac14_Fab1_bd PF12755.2 KOG98823.1 - 0.067 13.5 3.4 7.7 6.9 0.0 4.7 4 1 1 5 5 5 0 Vacuolar 14 Fab1-binding region HEAT_PBS PF03130.11 KOG98823.1 - 0.27 11.7 4.2 34 5.3 0.1 4.6 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Vfa1 PF08432.5 KOG98823.1 - 4.1 7.3 17.7 7.2 6.5 12.3 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 2-Hacid_dh_C PF02826.14 KOG98824.1 - 1e-52 177.8 0.0 1.7e-52 177.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 KOG98824.1 - 1.5e-38 131.2 0.1 2e-38 130.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 KOG98824.1 - 2.7e-05 24.0 0.2 7.4e-05 22.6 0.1 1.8 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.16 KOG98824.1 - 7.5e-05 22.6 0.0 0.00014 21.7 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Acetyltransf_1 PF00583.19 KOG98824.1 - 0.001 19.0 0.0 0.049 13.6 0.0 2.8 2 1 1 3 3 3 1 Acetyltransferase (GNAT) family ACT PF01842.20 KOG98824.1 - 0.0023 17.3 0.0 0.009 15.4 0.0 2.0 1 1 0 1 1 1 1 ACT domain DUF2703 PF10865.3 KOG98824.1 - 0.055 13.4 0.1 0.94 9.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2703) DUF262 PF03235.9 KOG98824.1 - 0.081 12.8 0.1 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF262 SPO22 PF08631.5 KOG98825.1 - 1.9e-79 266.6 9.9 1.9e-79 266.6 6.9 3.6 3 1 1 4 4 4 1 Meiosis protein SPO22/ZIP4 like Apc3 PF12895.2 KOG98825.1 - 0.011 15.8 2.0 0.045 13.8 0.6 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 KOG98825.1 - 0.11 12.4 0.2 2.6 8.0 0.0 2.9 1 1 1 2 2 2 0 Tetratricopeptide repeat HORMA PF02301.13 KOG98826.1 - 5.4e-48 163.2 2.2 5.4e-48 163.2 1.5 2.1 2 1 0 2 2 2 1 HORMA domain PHD_2 PF13831.1 KOG98826.1 - 0.048 12.9 2.9 0.091 12.0 2.0 1.5 1 0 0 1 1 1 0 PHD-finger PCI PF01399.22 KOG98827.1 - 0.004 17.4 0.2 0.013 15.8 0.1 2.0 1 1 0 1 1 1 1 PCI domain DYW_deaminase PF14432.1 KOG98827.1 - 0.057 13.4 0.2 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases CH PF00307.26 KOG98827.1 - 0.11 12.5 1.8 0.25 11.4 0.1 2.3 2 0 0 2 2 2 0 Calponin homology (CH) domain MAM33 PF02330.11 KOG98828.1 - 2e-72 243.2 8.2 2.3e-72 243.0 5.7 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein MiaE_2 PF13794.1 KOG98828.1 - 0.055 12.9 0.0 0.095 12.1 0.0 1.4 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like Ribosomal_S24e PF01282.14 KOG98829.1 - 2.5e-35 120.1 0.2 3.8e-35 119.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e RAMPs PF03787.10 KOG98829.1 - 0.017 14.9 0.5 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 RAMP superfamily SeleniumBinding PF11524.3 KOG98829.1 - 0.025 14.6 0.0 0.045 13.8 0.0 1.4 1 0 0 1 1 1 0 Selenium binding protein Sec6 PF06046.8 KOG98830.1 - 1.2e-171 571.6 10.1 2.1e-171 570.8 7.0 1.4 1 0 0 1 1 1 1 Exocyst complex component Sec6 LCCL PF03815.14 KOG98831.1 - 6e-09 35.7 0.1 1.1e-08 34.9 0.1 1.4 1 0 0 1 1 1 1 LCCL domain Ribonuc_red_lgC PF02867.10 KOG98832.1 - 2.9e-210 699.4 0.0 4.1e-210 698.9 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 KOG98832.1 - 1.9e-23 82.0 0.0 6.2e-23 80.4 0.0 2.0 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 KOG98832.1 - 1.6e-15 57.3 0.0 6.5e-15 55.3 0.0 2.2 1 0 0 1 1 1 1 ATP cone domain Fis1_TPR_C PF14853.1 KOG98833.1 - 3e-25 87.8 0.9 4.6e-25 87.2 0.6 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.1 KOG98833.1 - 1.1e-13 50.2 0.0 1.7e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_19 PF14559.1 KOG98833.1 - 0.094 13.0 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Ran_BP1 PF00638.13 KOG98834.1 - 5.6e-43 145.8 0.7 5.6e-43 145.8 0.5 2.2 2 0 0 2 2 2 1 RanBP1 domain P16-Arc PF04699.9 KOG98835.1 - 2.4e-51 173.7 0.0 2.7e-51 173.5 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) RolB_RolC PF02027.12 KOG98835.1 - 0.16 11.1 0.3 0.54 9.3 0.2 1.7 1 1 0 1 1 1 0 RolB/RolC glucosidase family U1snRNP70_N PF12220.3 KOG98836.1 - 1.4e-20 73.4 2.6 1.4e-20 73.4 1.8 1.8 2 0 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.17 KOG98836.1 - 3.5e-16 58.6 0.1 7.1e-16 57.5 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG98836.1 - 1.6e-11 43.9 0.1 3e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG98836.1 - 1e-06 28.4 0.2 1.8e-06 27.7 0.2 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3906 PF13046.1 KOG98836.1 - 0.036 13.6 0.2 0.065 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3906) Nup35_RRM_2 PF14605.1 KOG98836.1 - 0.086 12.6 0.1 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF2578 PF10843.3 KOG98837.1 - 2.9e-66 222.8 13.8 3.2e-66 222.7 9.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2578) DIX PF00778.12 KOG98837.1 - 0.0065 16.1 0.7 0.017 14.8 0.5 1.8 1 0 0 1 1 1 1 DIX domain Pkip-1 PF06878.6 KOG98837.1 - 0.014 15.2 0.5 0.026 14.4 0.4 1.5 1 0 0 1 1 1 0 Pkip-1 protein Acetone_carb_G PF08882.6 KOG98837.1 - 0.065 13.2 0.1 0.1 12.6 0.0 1.4 1 1 0 1 1 1 0 Acetone carboxylase gamma subunit CENP-L PF13092.1 KOG98837.1 - 0.091 12.5 0.2 0.1 12.3 0.1 1.3 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 Gp58 PF07902.6 KOG98837.1 - 0.094 10.9 0.1 0.11 10.7 0.1 1.0 1 0 0 1 1 1 0 gp58-like protein Vhr1 PF04001.8 KOG98838.1 - 2.9e-50 168.1 3.3 6.9e-50 166.9 2.3 1.7 1 0 0 1 1 1 1 Transcription factor Vhr1 HAD_2 PF13419.1 KOG98840.1 - 7.7e-13 49.0 0.0 1.1e-12 48.5 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOG98840.1 - 1.6e-08 35.2 0.0 3.9e-08 33.9 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOG98840.1 - 2.7e-07 30.1 0.0 4.9e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.2 KOG98840.1 - 0.0009 19.4 0.0 0.0012 19.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Ribonuc_L-PSP PF01042.16 KOG98841.1 - 4.4e-43 145.8 1.0 5.1e-43 145.6 0.7 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Cyclin PF08613.6 KOG98842.1 - 9.5e-51 172.1 0.1 1.4e-50 171.6 0.1 1.2 1 0 0 1 1 1 1 Cyclin Steroid_dh PF02544.11 KOG98843.1 - 1.1e-11 44.7 3.9 1.1e-11 44.7 2.7 1.8 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase UPF0239 PF06783.6 KOG98843.1 - 0.068 13.0 0.1 0.2 11.5 0.1 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) DUF2474 PF10617.4 KOG98843.1 - 1.6 8.4 4.1 0.5 9.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2474) E1-E2_ATPase PF00122.15 KOG98844.1 - 3.1e-31 108.1 0.0 6.7e-31 107.0 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 KOG98844.1 - 4.3e-13 50.1 0.0 7.2e-12 46.1 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOG98844.1 - 1.8e-10 41.3 0.0 5.6e-10 39.7 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOG98844.1 - 1e-08 34.9 0.0 3.5e-08 33.2 0.0 1.9 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 KOG98844.1 - 0.00044 19.9 0.1 0.0026 17.3 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase EXS PF03124.9 KOG98845.1 - 1.5e-92 310.3 26.0 2.2e-92 309.7 18.0 1.3 1 0 0 1 1 1 1 EXS family SPX PF03105.14 KOG98845.1 - 2e-38 132.7 0.3 2e-38 132.7 0.2 2.0 2 1 0 2 2 2 1 SPX domain WD40 PF00400.27 KOG98846.1 - 5e-49 162.5 25.3 2.5e-09 36.6 1.2 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat F-box-like PF12937.2 KOG98846.1 - 1.7e-14 53.2 2.1 3.4e-14 52.2 1.5 1.5 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.3 KOG98846.1 - 3e-11 42.1 5.7 0.11 10.6 0.0 5.9 1 1 5 6 6 6 5 Nucleoporin Nup120/160 F-box PF00646.28 KOG98846.1 - 1.8e-10 40.1 1.0 4.2e-10 39.0 0.7 1.7 1 0 0 1 1 1 1 F-box domain PRANC PF09372.5 KOG98846.1 - 0.038 13.9 2.9 0.078 12.9 2.0 1.5 1 0 0 1 1 1 0 PRANC domain CBM_21 PF03370.8 KOG98847.1 - 1.1e-30 105.9 1.0 2.4e-30 104.8 0.7 1.6 1 0 0 1 1 1 1 Putative phosphatase regulatory subunit ArfGap PF01412.13 KOG98848.1 - 2.7e-38 130.3 0.8 2.7e-38 130.3 0.5 2.2 2 1 0 2 2 2 1 Putative GTPase activating protein for Arf NAD_binding_1 PF00175.16 KOG98849.1 - 2e-31 108.7 0.0 3.2e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 KOG98849.1 - 1.3e-29 102.1 0.0 2.2e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 KOG98849.1 - 1.1e-07 31.8 0.0 0.00094 19.1 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.6 KOG98849.1 - 0.034 14.1 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain BCDHK_Adom3 PF10436.4 KOG98850.1 - 6.5e-27 94.0 0.3 1e-26 93.3 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 KOG98850.1 - 8.8e-20 70.4 0.0 1.4e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 KOG98850.1 - 0.00066 19.3 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 KOG98850.1 - 0.015 15.1 0.0 0.037 13.8 0.0 1.6 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain BAR_2 PF10455.4 KOG98851.1 - 1.6e-89 299.6 10.9 1.6e-89 299.6 7.6 1.7 1 1 1 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.13 KOG98851.1 - 4.5e-10 39.4 6.0 4.5e-10 39.4 4.1 2.2 2 1 1 3 3 3 1 BAR domain DUF3452 PF11934.3 KOG98851.1 - 0.059 12.6 3.9 0.06 12.6 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3452) DUF2422 PF10337.4 KOG98851.1 - 0.62 8.7 3.5 0.92 8.2 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) Syntaxin-6_N PF09177.6 KOG98851.1 - 2.6 8.5 6.6 7.7 6.9 0.2 3.4 2 2 1 3 3 3 0 Syntaxin 6, N-terminal Apq12 PF12716.2 KOG98852.1 - 0.00024 20.7 8.4 0.00024 20.7 5.9 1.9 2 0 0 2 2 2 1 Nuclear pore assembly and biogenesis Metallophos PF00149.23 KOG98853.1 - 4.6e-42 143.6 3.6 7.5e-42 143.0 2.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Acyl-CoA_ox_N PF14749.1 KOG98853.1 - 0.06 13.6 0.1 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal Not3 PF04065.10 KOG98854.1 - 2.5e-90 301.8 29.3 2.5e-90 301.8 20.3 2.8 2 1 1 3 3 3 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 KOG98854.1 - 3.9e-27 94.7 0.3 3.9e-27 94.7 0.2 3.0 3 0 0 3 3 3 1 NOT2 / NOT3 / NOT5 family MgtE PF01769.11 KOG98855.1 - 0.92 9.7 7.7 0.68 10.2 0.2 2.6 2 0 0 2 2 2 0 Divalent cation transporter DUF912 PF06024.7 KOG98855.1 - 2.1 8.4 8.5 7.4 6.6 0.1 3.5 2 1 2 4 4 4 0 Nucleopolyhedrovirus protein of unknown function (DUF912) bZIP_1 PF00170.16 KOG98856.1 - 8.4e-15 54.4 8.3 2.6e-14 52.9 5.8 1.9 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 KOG98856.1 - 1.1e-06 28.3 7.2 4.1e-06 26.5 5.0 2.0 1 0 0 1 1 1 1 Basic region leucine zipper MCR_alpha PF02249.12 KOG98856.1 - 0.12 12.4 3.4 0.33 10.9 0.6 2.5 2 0 0 2 2 2 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain bZIP_Maf PF03131.12 KOG98856.1 - 0.57 10.5 9.5 0.031 14.5 2.3 2.2 2 0 0 2 2 2 0 bZIP Maf transcription factor Pkinase PF00069.20 KOG98857.1 - 7.3e-54 182.6 5.2 2.6e-52 177.5 3.6 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98857.1 - 1e-18 67.3 1.5 4.5e-13 48.8 0.0 2.4 2 1 1 3 3 3 2 Protein tyrosine kinase APH PF01636.18 KOG98857.1 - 2.4e-05 24.1 0.1 0.0001 22.1 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 KOG98857.1 - 0.0034 16.9 0.6 0.015 14.8 0.1 2.1 2 0 0 2 2 2 1 Choline/ethanolamine kinase DUF496 PF04363.7 KOG98857.1 - 1.4 8.8 5.8 0.84 9.4 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF496) F_actin_cap_B PF01115.12 KOG98858.1 - 7.5e-103 342.9 0.0 8.6e-103 342.7 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit cNMP_binding PF00027.24 KOG98859.1 - 2.3e-45 152.3 0.1 3.6e-23 81.2 0.0 3.1 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain RIIa PF02197.12 KOG98859.1 - 1.6e-14 53.0 3.1 4.7e-14 51.5 2.1 1.9 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit ATP-synt_DE_N PF02823.11 KOG98859.1 - 0.15 11.8 0.5 10 5.9 0.0 2.3 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Cupin_2 PF07883.6 KOG98859.1 - 0.16 11.4 0.3 21 4.6 0.0 2.3 2 0 0 2 2 2 0 Cupin domain Peptidase_C48 PF02902.14 KOG98860.1 - 2.9e-45 154.5 9.0 2.9e-45 154.5 6.2 2.5 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain RINGv PF12906.2 KOG98861.1 - 2.7e-15 56.1 4.8 4.9e-15 55.3 3.3 1.5 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 KOG98861.1 - 0.014 15.2 4.7 0.028 14.2 3.2 1.6 1 0 0 1 1 1 0 Ring finger domain EmrE PF13536.1 KOG98862.1 - 0.0039 17.3 0.5 0.0039 17.3 0.3 2.0 2 0 0 2 2 2 1 Multidrug resistance efflux transporter Pox_A14 PF05767.7 KOG98862.1 - 0.42 10.5 3.9 0.49 10.3 0.5 2.4 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 MMgT PF10270.4 KOG98863.1 - 1.9e-26 92.5 0.1 2.3e-26 92.3 0.1 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter STAG PF08514.6 KOG98864.1 - 6.2e-08 32.3 1.7 2.6e-07 30.3 1.2 2.1 1 0 0 1 1 1 1 STAG domain Zip PF02535.17 KOG98866.1 - 5.5e-55 186.6 24.4 4.3e-54 183.6 13.9 2.4 2 1 0 2 2 2 1 ZIP Zinc transporter DUF1218 PF06749.7 KOG98866.1 - 0.00016 22.0 1.7 0.2 12.1 0.6 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF1218) DUF3054 PF11255.3 KOG98866.1 - 0.013 15.3 0.1 0.03 14.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3054) Tim44 PF04280.10 KOG98867.1 - 1.8e-34 118.8 0.1 4.3e-34 117.5 0.0 1.7 1 0 0 1 1 1 1 Tim44-like domain CCDC32 PF14989.1 KOG98867.1 - 0.038 13.8 0.6 0.57 10.0 0.2 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing 32 Spore_III_AB PF09548.5 KOG98867.1 - 0.12 12.0 0.7 0.41 10.3 0.1 2.1 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) RNA_pol_A_bac PF01000.21 KOG98868.1 - 4.5e-32 110.5 0.3 1.1e-31 109.2 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 KOG98868.1 - 2.1e-14 52.4 0.0 3e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Resolvase PF00239.16 KOG98868.1 - 0.077 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Resolvase, N terminal domain His_biosynth PF00977.16 KOG98869.1 - 1.4e-27 96.4 0.0 1.7e-27 96.2 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein DUF3152 PF11350.3 KOG98869.1 - 0.072 12.5 0.1 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3152) Ribosomal_L2_C PF03947.13 KOG98871.1 - 5.5e-41 139.4 2.0 8e-41 138.8 1.4 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 KOG98871.1 - 1.2e-13 50.7 0.2 2.7e-13 49.6 0.1 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain HEAT PF02985.17 KOG98872.1 - 0.002 18.0 1.8 7.9 6.8 0.1 5.1 5 0 0 5 5 5 1 HEAT repeat CENP-B_dimeris PF09026.5 KOG98872.1 - 0.44 10.8 6.6 1.1 9.4 4.5 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.7 KOG98872.1 - 2.9 7.0 8.2 4.9 6.3 5.7 1.2 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.4 KOG98872.1 - 7 5.2 10.8 11 4.6 7.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BAG PF02179.11 KOG98873.1 - 2.9e-19 68.9 2.7 4.5e-19 68.3 1.9 1.3 1 0 0 1 1 1 1 BAG domain DUF1980 PF09323.5 KOG98873.1 - 0.059 13.1 0.0 0.094 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Asp PF00026.18 KOG98874.1 - 1.1e-85 287.7 3.3 1.1e-85 287.7 2.3 1.9 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOG98874.1 - 3.7e-06 26.9 2.2 5.4e-06 26.4 0.0 2.3 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 KOG98874.1 - 0.02 14.4 0.0 0.079 12.4 0.0 2.1 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal ABC2_membrane PF01061.19 KOG98875.1 - 2.2e-68 229.5 62.2 9.9e-35 119.6 22.1 2.9 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.7 KOG98875.1 - 8.1e-31 105.7 4.3 3.3e-25 87.7 0.1 3.0 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.22 KOG98875.1 - 8.5e-28 97.3 0.0 1.1e-15 58.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.2 KOG98875.1 - 3.8e-08 32.7 56.2 1.4e-05 24.2 8.8 3.7 3 1 0 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.1 KOG98875.1 - 4.7e-06 26.7 8.7 0.046 13.6 0.1 3.9 3 1 0 4 4 4 3 AAA domain DUF258 PF03193.11 KOG98875.1 - 5.3e-05 22.4 0.0 0.0001 21.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SMC_N PF02463.14 KOG98875.1 - 0.0015 17.8 0.0 0.04 13.1 0.0 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_18 PF13238.1 KOG98875.1 - 0.0023 18.2 0.0 0.0076 16.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOG98875.1 - 0.01 15.9 0.0 0.043 13.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 KOG98875.1 - 0.014 15.7 0.1 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KOG98875.1 - 0.015 15.3 0.1 0.032 14.2 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.14 KOG98875.1 - 0.024 14.0 0.1 0.047 13.1 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 KOG98875.1 - 0.056 12.9 0.7 0.2 11.2 0.5 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRP1_TIP1 PF00660.12 KOG98876.1 - 6.2e-34 115.9 1.2 2.2e-33 114.1 0.8 2.0 1 0 0 1 1 1 1 Seripauperin and TIP1 family SLD3 PF08639.5 KOG98876.1 - 0.48 8.9 22.2 0.64 8.5 15.4 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 DUF936 PF06075.7 KOG98876.1 - 2.5 6.9 28.5 2.9 6.6 19.8 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) FAM196 PF15265.1 KOG98876.1 - 3.7 6.6 23.1 4.6 6.3 16.0 1.1 1 0 0 1 1 1 0 FAM196 family Hid1 PF12722.2 KOG98876.1 - 7.3 4.1 17.9 8.4 3.9 12.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF966 PF06136.8 KOG98876.1 - 8 5.7 26.8 10 5.4 18.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) AhpC-TSA PF00578.16 KOG98877.1 - 7.9e-28 96.6 0.0 1.1e-27 96.1 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KOG98877.1 - 2e-19 69.5 0.0 2.7e-19 69.1 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.1 KOG98877.1 - 0.02 14.7 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme TPP1 PF10341.4 KOG98878.1 - 8.5e-08 32.1 0.0 1.1e-07 31.8 0.0 1.1 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD DUF1736 PF08409.6 KOG98878.1 - 0.061 12.8 0.0 0.089 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1736) Sugar_tr PF00083.19 KOG98879.1 - 4.3e-171 569.4 35.1 4.9e-171 569.2 24.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG98879.1 - 2.9e-35 121.6 33.0 2e-32 112.3 13.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOG98879.1 - 2.7e-05 22.7 11.2 2.7e-05 22.7 7.8 3.7 3 2 1 4 4 4 2 MFS/sugar transport protein Cytochrom_B_N PF00033.14 KOG98879.1 - 0.00038 19.8 4.4 0.0019 17.5 0.0 3.6 4 1 0 4 4 4 1 Cytochrome b(N-terminal)/b6/petB MFS_3 PF05977.8 KOG98879.1 - 0.001 17.3 5.2 0.011 13.9 1.5 2.3 2 0 0 2 2 2 2 Transmembrane secretion effector PDR_CDR PF06422.7 KOG98879.1 - 2.7 7.6 0.0 2.7 7.6 0.0 4.2 4 0 0 4 4 4 0 CDR ABC transporter Urm1 PF09138.6 KOG98880.1 - 1.8e-33 114.5 0.4 2e-33 114.3 0.3 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.15 KOG98880.1 - 0.0032 17.8 0.0 0.0046 17.3 0.0 1.3 1 0 0 1 1 1 1 ThiS family PDZ PF00595.19 KOG98881.1 - 6.8e-09 35.7 0.2 1.3e-08 34.9 0.1 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOG98881.1 - 1.1e-06 28.4 0.0 2.3e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.9 KOG98881.1 - 0.0018 18.2 0.0 0.0034 17.3 0.0 1.4 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain DUF1463 PF07316.6 KOG98881.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1463) Mito_carr PF00153.22 KOG98882.1 - 1.2e-71 236.4 0.6 3.7e-25 87.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Thioredoxin PF00085.15 KOG98883.1 - 4.3e-27 93.8 1.6 2.9e-21 75.0 0.0 3.6 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.1 KOG98883.1 - 5.6e-07 29.5 13.3 4.3e-06 26.6 0.5 3.7 4 0 0 4 4 4 2 Thioredoxin-like domain Thioredoxin_2 PF13098.1 KOG98883.1 - 0.0088 16.2 4.3 1.6 8.9 0.0 3.9 4 1 0 4 4 4 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOG98883.1 - 0.046 13.8 2.1 0.39 10.8 0.0 3.5 4 0 0 4 4 4 0 Thioredoxin-like DUF1907 PF08925.6 KOG98883.1 - 0.076 12.0 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1907) SNARE PF05739.14 KOG98884.1 - 1.1e-09 37.7 0.6 1.6e-09 37.2 0.4 1.3 1 0 0 1 1 1 1 SNARE domain Sec20 PF03908.8 KOG98884.1 - 0.2 11.3 1.3 0.93 9.2 0.5 2.0 1 1 1 2 2 2 0 Sec20 ParA PF10609.4 KOG98885.1 - 4.4e-36 122.6 0.0 7.9e-36 121.7 0.0 1.4 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 KOG98885.1 - 1.5e-15 57.1 0.0 2.3e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 KOG98885.1 - 2.7e-07 29.9 0.0 1.1e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.10 KOG98885.1 - 1.5e-05 24.2 0.4 4e-05 22.8 0.1 1.8 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_31 PF13614.1 KOG98885.1 - 0.00041 20.2 0.0 0.0041 17.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain Fer4_NifH PF00142.13 KOG98885.1 - 0.0034 16.6 0.2 0.18 10.9 0.0 2.3 2 1 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArgK PF03308.11 KOG98885.1 - 0.0047 15.7 0.1 0.008 14.9 0.1 1.3 1 0 0 1 1 1 1 ArgK protein zf-C4_ClpX PF06689.8 KOG98885.1 - 0.018 14.5 3.1 0.033 13.6 2.1 1.4 1 0 0 1 1 1 0 ClpX C4-type zinc finger YhjQ PF06564.7 KOG98885.1 - 0.039 13.3 0.0 0.079 12.2 0.0 1.5 1 1 0 1 1 1 0 YhjQ protein APS_kinase PF01583.15 KOG98885.1 - 0.075 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_25 PF13481.1 KOG98885.1 - 0.086 12.2 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain HR1 PF02185.11 KOG98886.1 - 0.00061 19.4 1.2 0.00079 19.1 0.8 1.2 1 0 0 1 1 1 1 Hr1 repeat Viral_P18 PF04521.8 KOG98886.1 - 0.08 12.3 0.2 0.095 12.1 0.1 1.2 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein FlaC_arch PF05377.6 KOG98886.1 - 0.11 12.3 0.8 0.24 11.2 0.6 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Laminin_II PF06009.7 KOG98886.1 - 0.16 11.7 0.4 0.23 11.2 0.3 1.4 1 1 0 1 1 1 0 Laminin Domain II Syja_N PF02383.13 KOG98887.1 - 3.3e-61 206.8 4.5 3.3e-61 206.7 0.6 2.1 2 0 0 2 2 2 1 SacI homology domain Exo_endo_phos PF03372.18 KOG98887.1 - 1.4e-24 87.4 0.0 2.4e-24 86.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BTB PF00651.26 KOG98888.1 - 3.9e-32 110.5 0.9 5.5e-20 71.4 0.0 2.4 2 0 0 2 2 2 2 BTB/POZ domain Ank PF00023.25 KOG98888.1 - 8.8e-10 37.9 0.1 7.1e-06 25.5 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 KOG98888.1 - 1.1e-08 35.3 0.0 5.5e-08 33.0 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOG98888.1 - 5.7e-08 33.0 0.0 6.2e-07 29.7 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOG98888.1 - 0.00018 21.4 0.0 0.4 11.0 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOG98888.1 - 0.00094 19.3 0.0 0.0048 17.1 0.0 2.3 2 1 0 2 2 2 1 Ankyrin repeats (many copies) RRM_1 PF00076.17 KOG98889.1 - 4.5e-21 74.2 0.0 8e-21 73.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG98889.1 - 4.4e-16 58.6 0.0 6.7e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG98889.1 - 4.1e-08 32.9 0.0 8.3e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Helicase_C PF00271.26 KOG98890.1 - 5.5e-20 71.0 0.1 1.6e-19 69.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOG98890.1 - 9.4e-19 67.5 0.0 2.3e-17 63.0 0.0 3.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.10 KOG98890.1 - 2.9e-17 63.1 0.0 2.9e-17 63.1 0.0 4.6 5 0 0 5 5 5 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOG98890.1 - 0.0027 17.8 0.0 0.12 12.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain STAT_int PF02865.12 KOG98890.1 - 0.0056 16.6 0.1 0.023 14.6 0.0 2.2 1 0 0 1 1 1 1 STAT protein, protein interaction domain DUF3210 PF11489.3 KOG98891.1 - 4.3e-27 95.1 52.9 4.3e-27 95.1 36.7 3.1 2 1 2 4 4 4 2 Protein of unknown function (DUF3210) polyprenyl_synt PF00348.12 KOG98891.1 - 0.27 10.0 4.2 7.4 5.3 0.1 3.3 2 1 1 3 3 3 0 Polyprenyl synthetase DnaJ-X PF14308.1 KOG98892.1 - 1.4e-66 223.7 5.2 1.4e-66 223.7 3.6 2.2 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.26 KOG98892.1 - 1.9e-24 85.1 0.8 1.9e-24 85.1 0.6 2.2 2 0 0 2 2 2 1 DnaJ domain DUF3275 PF11679.3 KOG98892.1 - 1.3 8.5 8.5 0.38 10.3 2.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) RRM_1 PF00076.17 KOG98893.1 - 1.4e-19 69.4 0.0 2.2e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG98893.1 - 1.8e-12 47.0 0.0 2.6e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG98893.1 - 3.6e-08 33.1 0.0 6.2e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EF-hand_4 PF12763.2 KOG98894.1 - 7.2e-27 93.1 0.0 2.9e-13 49.4 0.0 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.1 KOG98894.1 - 4.3e-06 26.7 0.0 0.0037 17.3 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain pair DUF1720 PF08226.6 KOG98894.1 - 1.4e-05 25.0 58.2 9.4e-05 22.4 14.2 9.9 5 2 4 9 9 9 4 Domain of unknown function (DUF1720) EF-hand_1 PF00036.27 KOG98894.1 - 0.00014 20.9 0.0 0.032 13.5 0.0 3.5 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.1 KOG98894.1 - 0.0046 16.7 0.1 17 5.6 0.0 4.1 5 0 0 5 5 5 1 EF-hand domain Cellulase PF00150.13 KOG98895.1 - 1.7e-15 56.9 0.1 1.4e-09 37.5 0.0 2.6 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_35 PF01301.14 KOG98895.1 - 0.0041 16.5 0.0 0.008 15.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 SIR2_2 PF13289.1 KOG98895.1 - 0.049 13.5 0.0 0.35 10.7 0.0 2.3 2 0 0 2 2 2 0 SIR2-like domain DNA_primase_S PF01896.14 KOG98896.1 - 9.9e-55 184.3 0.3 1.6e-54 183.6 0.2 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit Gag_p30 PF02093.11 KOG98896.1 - 0.032 13.4 1.0 0.074 12.2 0.1 1.9 2 0 0 2 2 2 0 Gag P30 core shell protein RRM_5 PF13893.1 KOG98897.1 - 1.1e-13 50.7 0.1 4.8e-13 48.7 0.0 1.8 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG98897.1 - 6.5e-08 32.4 0.0 1.4e-07 31.3 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOG98897.1 - 1e-07 31.4 0.2 1.9e-07 30.6 0.1 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIS13 PF08202.6 KOG98898.1 - 4.2e-95 318.2 15.9 4.2e-95 318.2 11.0 1.4 2 0 0 2 2 2 1 Mis12-Mtw1 protein family OAD_gamma PF04277.8 KOG98898.1 - 0.38 11.1 1.9 0.48 10.8 0.1 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Cut8_C PF08559.5 KOG98899.1 - 1.7e-49 167.3 1.0 2.8e-49 166.6 0.7 1.3 1 0 0 1 1 1 1 Cut8 six-helix bundle Cut8_M PF14483.1 KOG98899.1 - 1.1e-14 53.8 5.2 2.1e-14 53.0 3.6 1.4 1 0 0 1 1 1 1 Cut8 dimerisation domain WD40 PF00400.27 KOG98900.1 - 3.8e-06 26.5 14.4 0.0014 18.4 0.5 5.5 7 0 0 7 7 7 3 WD domain, G-beta repeat PQQ_2 PF13360.1 KOG98900.1 - 1.2e-05 24.8 0.1 0.053 12.9 0.0 2.8 1 1 2 3 3 3 3 PQQ-like domain Apc4_WD40 PF12894.2 KOG98900.1 - 0.00085 18.7 0.0 0.034 13.6 0.0 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain GATA PF00320.22 KOG98901.1 - 4.7e-13 48.2 3.9 6.9e-13 47.6 2.7 1.3 1 0 0 1 1 1 1 GATA zinc finger Rpr2 PF04032.11 KOG98903.1 - 1.5e-13 50.4 0.1 2e-13 50.0 0.1 1.3 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF3133 PF11331.3 KOG98903.1 - 0.015 14.8 0.3 0.026 14.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3133) DUF1844 PF08899.6 KOG98903.1 - 0.087 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1844) bZIP_2 PF07716.10 KOG98905.1 - 1.2e-09 37.8 12.9 1.2e-09 37.8 9.0 1.9 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.12 KOG98905.1 - 0.0053 17.0 9.1 0.0053 17.0 6.3 2.6 2 1 1 3 3 3 1 bZIP Maf transcription factor bZIP_1 PF00170.16 KOG98905.1 - 0.021 14.7 16.4 0.021 14.7 11.3 2.8 2 1 0 2 2 2 0 bZIP transcription factor Herpes_UL6 PF01763.11 KOG98905.1 - 0.11 10.6 3.9 0.14 10.2 2.7 1.2 1 0 0 1 1 1 0 Herpesvirus UL6 like TSC22 PF01166.13 KOG98905.1 - 0.2 11.6 2.5 0.21 11.6 0.3 2.1 2 1 0 2 2 2 0 TSC-22/dip/bun family PRP1_N PF06424.7 KOG98905.1 - 0.21 11.9 6.4 0.33 11.2 4.4 1.4 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DivIC PF04977.10 KOG98905.1 - 0.54 9.7 8.2 0.093 12.2 0.9 2.4 2 0 0 2 2 2 0 Septum formation initiator DASH_Dad3 PF08656.5 KOG98905.1 - 0.77 9.4 4.7 4.1 7.1 0.4 2.6 2 0 0 2 2 2 0 DASH complex subunit Dad3 GA PF01468.12 KOG98905.1 - 0.79 9.9 5.8 2.1 8.5 0.7 3.0 2 1 1 3 3 3 0 GA module PIN_4 PF13638.1 KOG98905.1 - 1.4 8.9 5.9 0.61 10.1 2.3 1.7 2 0 0 2 2 2 0 PIN domain BLOC1_2 PF10046.4 KOG98905.1 - 2 8.6 9.2 1.1 9.4 1.1 2.7 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 bZIP_1 PF00170.16 KOG98906.1 - 6.5e-07 29.2 15.4 3.2e-06 27.0 9.1 2.5 1 1 1 2 2 2 1 bZIP transcription factor Glutaredoxin2_C PF04399.8 KOG98906.1 - 0.00058 19.4 2.8 0.0009 18.8 1.9 1.2 1 0 0 1 1 1 1 Glutaredoxin 2, C terminal domain CENP-Q PF13094.1 KOG98906.1 - 0.0027 17.7 10.2 0.0046 16.9 7.0 1.4 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Prefoldin_2 PF01920.15 KOG98906.1 - 0.0048 16.6 2.6 0.0048 16.6 1.8 1.8 1 1 1 2 2 2 1 Prefoldin subunit DUF4515 PF14988.1 KOG98906.1 - 0.0077 15.9 11.0 0.011 15.4 7.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4515) IncA PF04156.9 KOG98906.1 - 0.0096 15.5 7.6 0.015 14.9 5.3 1.2 1 0 0 1 1 1 1 IncA protein ATG16 PF08614.6 KOG98906.1 - 0.0098 15.7 6.6 0.017 14.9 4.6 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF4200 PF13863.1 KOG98906.1 - 0.012 15.5 8.4 0.022 14.6 5.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) CR6_interact PF10147.4 KOG98906.1 - 0.015 14.5 3.4 0.029 13.7 2.3 1.4 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF4407 PF14362.1 KOG98906.1 - 0.016 14.1 2.8 0.025 13.5 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF641 PF04859.7 KOG98906.1 - 0.017 14.8 7.1 0.032 13.9 4.9 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) SlyX PF04102.7 KOG98906.1 - 0.018 15.4 1.8 0.018 15.4 1.2 2.9 3 1 0 3 3 2 0 SlyX Reo_sigmaC PF04582.7 KOG98906.1 - 0.033 13.3 0.3 0.047 12.8 0.2 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein ADIP PF11559.3 KOG98906.1 - 0.041 13.7 10.9 0.068 13.0 7.6 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Sipho_Gp157 PF05565.6 KOG98906.1 - 0.053 13.0 2.7 0.077 12.5 1.3 1.7 2 0 0 2 2 2 0 Siphovirus Gp157 USP8_interact PF08941.5 KOG98906.1 - 0.077 12.3 0.4 0.15 11.3 0.3 1.4 1 0 0 1 1 1 0 USP8 interacting Ribosomal_L20 PF00453.13 KOG98906.1 - 0.11 12.4 5.5 0.036 13.9 1.2 1.9 2 0 0 2 2 2 0 Ribosomal protein L20 APG6 PF04111.7 KOG98906.1 - 0.15 11.0 7.1 0.2 10.6 4.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1664 PF07889.7 KOG98906.1 - 0.15 11.8 2.5 0.24 11.1 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) HlyD PF00529.15 KOG98906.1 - 0.22 10.8 5.6 0.29 10.4 3.9 1.1 1 0 0 1 1 1 0 HlyD family secretion protein Phage_lysis PF03245.8 KOG98906.1 - 0.24 11.3 8.9 0.42 10.6 6.2 1.4 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein Exonuc_VII_L PF02601.10 KOG98906.1 - 0.52 9.4 6.3 0.65 9.1 4.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.14 KOG98906.1 - 0.52 8.0 4.2 0.66 7.7 2.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CCDC-167 PF15188.1 KOG98906.1 - 0.62 10.0 5.5 0.74 9.8 2.9 2.0 2 0 0 2 2 1 0 Coiled-coil domain-containing protein 167 Nnf1 PF03980.9 KOG98906.1 - 0.71 9.8 7.7 1.7 8.6 5.3 1.7 1 0 0 1 1 1 0 Nnf1 TMF_DNA_bd PF12329.3 KOG98906.1 - 1.2 8.9 10.6 0.27 11.0 4.4 2.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding YvrJ PF12841.2 KOG98906.1 - 1.6 8.0 3.2 3.1 7.1 0.3 2.6 3 0 0 3 3 3 0 YvrJ protein family TBPIP PF07106.8 KOG98906.1 - 2 7.9 9.5 3.6 7.0 5.9 1.7 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DivIC PF04977.10 KOG98906.1 - 3.4 7.2 10.5 5.2 6.6 0.9 2.5 1 1 1 2 2 2 0 Septum formation initiator DUF972 PF06156.8 KOG98906.1 - 3.6 7.9 10.1 0.13 12.6 2.2 2.1 1 1 2 3 3 2 0 Protein of unknown function (DUF972) DUF4140 PF13600.1 KOG98906.1 - 9.3 6.7 9.5 1.6e+02 2.8 6.5 2.2 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Flo11 PF10182.4 KOG98907.1 - 5.7e-58 194.8 7.4 1.2e-57 193.7 5.2 1.6 1 0 0 1 1 1 1 Flo11 domain Ydc2-catalyt PF09159.5 KOG98908.1 - 3.4e-22 79.2 0.0 4.4e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Peptidase_S24 PF00717.18 KOG98909.1 - 1.6e-09 37.2 0.0 3e-09 36.3 0.0 1.6 1 1 0 1 1 1 1 Peptidase S24-like Fungal_trans PF04082.13 KOG98910.1 - 1.1e-30 106.4 3.2 1.1e-30 106.4 2.2 2.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG98910.1 - 2.8e-07 30.3 8.1 5.7e-07 29.3 5.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3801 PF12687.2 KOG98911.1 - 5.6 6.4 7.5 31 4.0 5.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3801) Apc15p PF05841.6 KOG98912.1 - 8e-28 97.6 1.7 1e-27 97.3 0.2 1.9 2 0 0 2 2 2 1 Apc15p protein DSPc PF00782.15 KOG98913.1 - 3.6e-25 88.0 0.1 9.1e-24 83.5 0.1 2.3 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOG98913.1 - 0.0015 17.8 0.0 0.0041 16.4 0.0 1.6 1 1 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 KOG98913.1 - 0.0024 17.9 0.0 0.0053 16.8 0.0 1.6 2 0 0 2 2 2 1 Inositol hexakisphosphate Yippee-Mis18 PF03226.9 KOG98913.1 - 0.01 15.8 1.1 0.087 12.8 0.7 2.3 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Eapp_C PF10238.4 KOG98913.1 - 0.023 14.6 0.4 1.4 8.8 0.1 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein Sgf11 PF08209.6 KOG98913.1 - 0.044 13.0 1.0 1.1 8.5 0.0 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Elf1 PF05129.8 KOG98913.1 - 0.082 12.6 0.6 14 5.4 0.0 2.7 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like UPF0547 PF10571.4 KOG98913.1 - 1 9.1 4.6 11 5.8 0.0 2.7 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 Amidohydro_1 PF01979.15 KOG98914.1 - 1.8e-40 139.5 0.0 2.2e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 KOG98914.1 - 2.7e-23 83.4 0.0 6.2e-23 82.1 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_5 PF13594.1 KOG98914.1 - 1.5e-10 40.7 0.1 5.3e-10 38.9 0.1 1.9 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_3 PF07969.6 KOG98914.1 - 9.1e-07 28.4 0.1 0.006 15.8 0.0 2.8 3 0 0 3 3 3 2 Amidohydrolase family Transp_cyt_pur PF02133.10 KOG98915.1 - 2.8e-178 593.0 35.9 3.3e-178 592.7 24.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Allantoicase PF03561.10 KOG98916.1 - 1.1e-107 356.0 0.7 7.6e-58 194.2 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat Asp_Glu_race PF01177.17 KOG98917.1 - 3.2e-18 66.4 0.0 3.7e-18 66.2 0.0 1.0 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase Malate_synthase PF01274.17 KOG98918.1 - 1.1e-222 739.6 0.0 1.4e-222 739.3 0.0 1.0 1 0 0 1 1 1 1 Malate synthase Ureidogly_hydro PF04115.7 KOG98919.1 - 3.4e-45 153.3 0.0 3.8e-45 153.2 0.0 1.0 1 0 0 1 1 1 1 Ureidoglycolate hydrolase Ank PF00023.25 KOG98920.1 - 7.3e-15 53.9 0.1 2.1e-06 27.2 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 KOG98920.1 - 2.3e-12 47.0 0.1 8.5e-12 45.2 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOG98920.1 - 3.2e-12 46.6 0.4 2.8e-10 40.4 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOG98920.1 - 6.7e-11 41.3 0.2 0.00019 21.3 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOG98920.1 - 1.2e-10 41.2 0.2 1.3e-06 28.4 0.0 3.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) TIG PF01833.19 KOG98920.1 - 3.5e-08 33.3 0.5 1.2e-07 31.6 0.4 1.9 1 0 0 1 1 1 1 IPT/TIG domain AlaDh_PNT_N PF05222.10 KOG98921.1 - 1.1e-29 103.1 0.0 1.6e-29 102.6 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 KOG98921.1 - 1.2e-15 57.4 0.0 1.6e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.20 KOG98922.1 - 1.9e-27 96.2 0.0 2.4e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOG98922.1 - 1e-15 58.1 0.1 1.3e-15 57.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOG98922.1 - 1.4e-07 31.3 0.0 2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 KOG98922.1 - 6.2e-05 22.5 0.2 0.00034 20.1 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family tRNA_m1G_MT PF01746.16 KOG98922.1 - 0.01 15.4 0.1 0.019 14.5 0.1 1.4 1 0 0 1 1 1 0 tRNA (Guanine-1)-methyltransferase TrkA_N PF02254.13 KOG98922.1 - 0.013 15.4 0.2 0.031 14.2 0.0 1.7 2 0 0 2 2 2 0 TrkA-N domain RBDV_coat PF06593.6 KOG98922.1 - 0.043 13.0 0.6 0.063 12.5 0.4 1.3 1 0 0 1 1 1 0 Raspberry bushy dwarf virus coat protein NAD_binding_10 PF13460.1 KOG98922.1 - 0.05 13.6 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 NADH(P)-binding 3Beta_HSD PF01073.14 KOG98922.1 - 0.061 12.0 0.2 0.091 11.4 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 KOG98923.1 - 8.7e-35 120.0 0.0 1.2e-34 119.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOG98923.1 - 8.3e-19 68.3 0.0 1e-18 68.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOG98923.1 - 1.5e-13 50.7 0.1 2.7e-13 49.9 0.0 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 KOG98923.1 - 6.4e-05 22.5 0.2 0.00047 19.6 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 KOG98923.1 - 0.0036 16.2 0.0 0.0099 14.8 0.0 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein GSHPx PF00255.14 KOG98924.1 - 4.1e-48 161.2 0.2 5.3e-48 160.8 0.1 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 KOG98924.1 - 7.3e-06 25.6 0.1 5e-05 22.9 0.1 2.0 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KOG98924.1 - 1.5e-05 24.5 0.0 5.4e-05 22.7 0.0 1.9 1 1 0 1 1 1 1 Redoxin DUF4174 PF13778.1 KOG98924.1 - 0.0096 16.0 0.0 0.017 15.2 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4174) GST_N PF02798.15 KOG98925.1 - 1.4e-15 57.2 0.0 2.5e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 KOG98925.1 - 6e-11 42.1 0.0 9.3e-11 41.5 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 KOG98925.1 - 4.1e-07 29.8 0.0 9.5e-07 28.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 KOG98925.1 - 5.4e-07 29.7 0.0 1.2e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 KOG98925.1 - 2.3e-05 24.7 0.0 5.9e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 KOG98925.1 - 0.017 14.9 0.0 0.038 13.8 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Fungal_trans PF04082.13 KOG98926.1 - 3.6e-16 58.8 2.6 7.8e-16 57.7 1.8 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG98926.1 - 1.4e-05 24.8 13.6 3e-05 23.8 9.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Afi1 PF07792.7 KOG98926.1 - 0.031 14.3 0.8 0.062 13.3 0.5 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MFS_1 PF07690.11 KOG98927.1 - 2.3e-20 72.6 48.7 3.8e-20 71.8 33.8 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Peptidase_M20 PF01546.23 KOG98928.1 - 2.4e-25 89.1 0.0 3.5e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 KOG98928.1 - 1.1e-12 47.7 0.0 2.1e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain FAD_binding_8 PF08022.7 KOG98929.1 - 3.9e-19 68.4 0.0 7.7e-19 67.5 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 KOG98929.1 - 4.1e-19 69.0 0.1 6e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 KOG98929.1 - 1.7e-15 57.2 9.4 1.7e-15 57.2 6.5 1.9 2 1 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 KOG98929.1 - 0.00066 19.7 0.0 0.0014 18.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain 3Beta_HSD PF01073.14 KOG98930.1 - 6.3e-13 48.0 0.0 8.2e-13 47.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 KOG98930.1 - 1.4e-12 47.6 0.0 2.7e-12 46.6 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 KOG98930.1 - 1.7e-07 31.4 0.0 3.8e-07 30.2 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 KOG98930.1 - 9.4e-05 21.4 0.0 0.00051 19.0 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 KOG98930.1 - 0.00022 21.1 0.0 0.00047 20.1 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 KOG98930.1 - 0.0056 15.9 0.0 0.35 10.0 0.0 2.2 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.10 KOG98930.1 - 0.0057 15.5 0.0 0.013 14.4 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein F420_oxidored PF03807.12 KOG98930.1 - 0.017 15.5 0.0 0.25 11.8 0.0 2.5 3 0 0 3 3 2 0 NADP oxidoreductase coenzyme F420-dependent RmlD_sub_bind PF04321.12 KOG98930.1 - 0.11 11.3 0.0 1.2 7.9 0.0 2.2 2 0 0 2 2 2 0 RmlD substrate binding domain DXP_redisom_C PF08436.7 KOG98930.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal Med30 PF11315.3 KOG98930.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 30 DCP1 PF06058.8 KOG98931.1 - 1.3e-17 64.0 3.2 1e-09 38.4 0.0 3.0 2 1 1 3 3 3 3 Dcp1-like decapping family Spt20 PF12090.3 KOG98932.1 - 9.2e-58 194.5 6.2 9.2e-58 194.5 4.3 3.3 3 1 0 3 3 3 1 Spt20 family PEX11 PF05648.9 KOG98933.1 - 3e-64 216.3 4.0 3.4e-64 216.1 2.8 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Sld5 PF05916.6 KOG98934.1 - 1e-16 61.1 0.0 1.3e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 GINS complex protein TPR_2 PF07719.12 KOG98935.1 - 4.1e-29 98.1 18.1 0.013 15.3 0.0 12.1 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_11 PF13414.1 KOG98935.1 - 9.5e-25 86.0 21.1 5.9e-06 25.8 0.0 10.3 7 2 5 12 12 12 8 TPR repeat TPR_12 PF13424.1 KOG98935.1 - 2.9e-20 71.9 23.0 1.9e-05 24.5 0.0 10.9 5 3 7 13 13 13 6 Tetratricopeptide repeat TPR_1 PF00515.23 KOG98935.1 - 3.4e-20 70.7 34.9 7.4e-05 22.1 0.0 11.9 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_19 PF14559.1 KOG98935.1 - 5.4e-19 68.2 7.7 0.0019 18.4 0.0 9.6 10 1 1 11 11 10 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOG98935.1 - 2e-16 58.9 0.5 0.14 12.8 0.0 11.3 9 2 3 12 12 12 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOG98935.1 - 4.2e-16 59.1 0.0 0.13 12.9 0.0 8.4 8 1 1 9 9 9 4 Tetratricopeptide repeat Apc3 PF12895.2 KOG98935.1 - 5e-15 55.4 15.8 0.0075 16.3 0.0 8.3 5 4 3 8 8 8 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 KOG98935.1 - 5.5e-14 50.8 29.4 0.036 13.8 0.0 11.9 12 0 0 12 12 11 5 Tetratricopeptide repeat TPR_6 PF13174.1 KOG98935.1 - 2.1e-12 46.6 16.6 4.7 7.8 0.0 12.6 14 0 0 14 14 14 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOG98935.1 - 2.7e-08 32.9 13.7 0.92 9.4 0.0 10.3 12 0 0 12 12 12 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOG98935.1 - 7.6e-08 32.0 4.9 0.029 14.3 0.0 8.2 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOG98935.1 - 5.7e-07 29.2 5.9 29 5.1 0.0 10.1 11 0 0 11 11 10 0 Tetratricopeptide repeat RRM_5 PF13893.1 KOG98936.1 - 1e-07 31.6 0.7 2.3e-07 30.5 0.5 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOG98936.1 - 5.1e-05 22.8 3.5 0.00029 20.4 1.3 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG98936.1 - 0.00011 22.1 0.5 0.00038 20.3 0.2 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) MAPKK1_Int PF08923.5 KOG98936.1 - 0.028 14.0 0.0 0.18 11.4 0.0 2.1 2 0 0 2 2 2 0 Mitogen-activated protein kinase kinase 1 interacting DMRL_synthase PF00885.14 KOG98937.1 - 4e-44 149.7 0.1 4.9e-44 149.4 0.1 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase OprF PF05736.6 KOG98937.1 - 0.086 12.3 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 OprF membrane domain LCM PF04072.9 KOG98939.1 - 1.5e-28 99.6 0.0 2.7e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.1 KOG98939.1 - 5.1e-16 58.1 2.7 1.1e-08 34.7 0.0 5.1 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_6 PF13964.1 KOG98939.1 - 7.4e-12 44.9 6.4 0.0022 18.1 0.0 6.0 5 1 1 6 6 6 3 Kelch motif Kelch_3 PF13415.1 KOG98939.1 - 1.6e-10 40.8 0.0 0.03 14.4 0.0 5.0 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KOG98939.1 - 5.8e-09 35.3 2.9 0.0026 17.4 0.0 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.1 KOG98939.1 - 1.6e-07 31.1 0.1 0.72 9.8 0.0 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 KOG98939.1 - 1.3e-05 24.6 0.1 0.0043 16.5 0.0 4.3 5 0 0 5 5 5 1 Kelch motif DUF512 PF04459.7 KOG98939.1 - 0.13 11.3 0.0 0.28 10.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF512) Aminotran_3 PF00202.16 KOG98940.1 - 1.5e-114 382.4 0.1 1.8e-114 382.1 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-III PucR PF07905.6 KOG98940.1 - 0.0058 16.1 0.0 0.31 10.6 0.0 2.9 3 0 0 3 3 3 1 Purine catabolism regulatory protein-like family Aminotran_5 PF00266.14 KOG98940.1 - 0.021 13.6 0.0 0.033 12.9 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class-V IF4E PF01652.13 KOG98941.1 - 1.4e-56 190.5 0.1 1.8e-56 190.2 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E WD40 PF00400.27 KOG98942.1 - 5.9e-18 64.0 0.4 2.2e-08 33.6 0.0 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat zf-RING_2 PF13639.1 KOG98942.1 - 5.3e-06 26.1 4.5 1.5e-05 24.7 3.1 1.8 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOG98942.1 - 2.5e-05 24.2 3.6 2.5e-05 24.2 2.5 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 KOG98942.1 - 0.00013 21.8 4.5 0.00013 21.8 3.1 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOG98942.1 - 0.00014 21.4 0.9 0.00014 21.4 0.7 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOG98942.1 - 0.047 13.5 4.7 0.13 12.1 3.3 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 KOG98942.1 - 0.49 10.1 9.7 0.09 12.5 3.6 2.2 2 1 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOG98942.1 - 2.7 7.7 10.0 0.063 12.9 1.6 2.2 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) MFS_1 PF07690.11 KOG98943.1 - 6.6e-26 90.8 53.7 1.7e-25 89.5 20.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1228 PF06779.9 KOG98943.1 - 0.087 12.8 4.4 0.53 10.3 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1228) 6PF2K PF01591.13 KOG98944.1 - 1.8e-75 252.8 3.7 3.2e-75 252.0 2.5 1.4 1 0 0 1 1 1 1 6-phosphofructo-2-kinase KTI12 PF08433.5 KOG98944.1 - 0.00096 18.4 0.0 0.0019 17.4 0.0 1.5 1 1 1 2 2 2 1 Chromatin associated protein KTI12 AAA_33 PF13671.1 KOG98944.1 - 0.0016 18.3 0.0 0.0031 17.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOG98944.1 - 0.0028 17.9 0.8 0.008 16.4 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 KOG98944.1 - 0.0043 17.8 0.0 0.012 16.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.15 KOG98944.1 - 0.066 12.8 0.0 1.7 8.2 0.0 2.2 2 0 0 2 2 2 0 Adenylylsulphate kinase DUF234 PF03008.9 KOG98944.1 - 0.14 12.2 0.2 0.14 12.2 0.2 2.1 2 0 0 2 2 2 0 Archaea bacterial proteins of unknown function AAA_22 PF13401.1 KOG98944.1 - 0.14 12.2 0.0 0.34 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Med7 PF05983.6 KOG98945.1 - 8.3e-68 227.2 2.6 9.8e-68 227.0 1.8 1.1 1 0 0 1 1 1 1 MED7 protein Prefoldin_2 PF01920.15 KOG98945.1 - 0.12 12.1 0.3 0.12 12.1 0.2 2.4 3 0 0 3 3 3 0 Prefoldin subunit zf-rbx1 PF12678.2 KOG98946.1 - 2.8e-32 110.6 13.8 4.2e-32 110.0 9.6 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 KOG98946.1 - 6e-17 61.2 10.1 8.5e-17 60.7 7.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 KOG98946.1 - 3.8e-07 29.8 11.8 3e-06 26.9 8.1 2.1 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 KOG98946.1 - 0.0019 17.8 11.9 0.019 14.5 8.3 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOG98946.1 - 0.016 15.2 2.0 0.016 15.2 1.4 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 KOG98946.1 - 0.037 13.5 2.9 0.087 12.3 2.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.1 KOG98946.1 - 0.06 13.0 10.2 2.6 7.7 7.1 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KOG98946.1 - 0.18 11.7 6.9 0.19 11.5 0.3 2.5 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 KOG98946.1 - 0.54 10.0 10.3 4.2 7.1 7.2 2.3 1 1 1 2 2 2 0 zinc-RING finger domain FANCL_C PF11793.3 KOG98946.1 - 1.2 9.1 9.7 7.2 6.6 6.9 2.1 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_UBOX PF13445.1 KOG98946.1 - 2 8.2 11.8 0.2 11.3 2.9 3.0 2 1 1 3 3 3 0 RING-type zinc-finger Glyco_hydro_72 PF03198.9 KOG98947.1 - 7.5e-138 458.7 4.0 9.3e-138 458.4 2.8 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.13 KOG98947.1 - 4.2e-05 22.8 0.1 0.00016 21.0 0.0 1.9 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) RNR_N PF08343.5 KOG98947.1 - 0.24 11.2 2.7 0.54 10.0 0.4 2.4 2 0 0 2 2 2 0 Ribonucleotide reductase N-terminal MbtH PF03621.8 KOG98948.1 - 0.053 12.8 0.0 0.087 12.2 0.0 1.3 1 0 0 1 1 1 0 MbtH-like protein CorA PF01544.13 KOG98949.1 - 2e-40 138.6 2.1 5.4e-25 88.0 0.0 2.2 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein DUF2231 PF09990.4 KOG98949.1 - 0.017 15.4 0.5 0.036 14.4 0.3 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2231) UPF0220 PF05255.6 KOG98950.1 - 1.6e-68 229.1 1.0 1.8e-68 228.9 0.7 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Pkinase PF00069.20 KOG98951.1 - 3.9e-53 180.2 0.0 5.2e-53 179.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98951.1 - 1.2e-22 80.2 0.0 1.7e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG98951.1 - 0.003 16.5 0.0 0.005 15.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pox_ser-thr_kin PF05445.6 KOG98951.1 - 0.004 16.0 0.2 0.0066 15.2 0.1 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase APH PF01636.18 KOG98951.1 - 0.018 14.7 0.0 0.042 13.5 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1679 PF07914.6 KOG98951.1 - 0.045 12.3 0.1 3.6 6.1 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1679) Kdo PF06293.9 KOG98951.1 - 0.077 12.0 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L23 PF00276.15 KOG98952.1 - 4.2e-17 61.8 1.7 5.1e-17 61.5 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L23 Levi_coat PF01819.12 KOG98952.1 - 0.0043 16.6 0.1 0.0052 16.3 0.1 1.1 1 0 0 1 1 1 1 Levivirus coat protein Lipoprotein_1 PF00820.14 KOG98952.1 - 0.11 11.5 0.1 0.12 11.4 0.1 1.0 1 0 0 1 1 1 0 Borrelia lipoprotein STN1_2 PF09170.5 KOG98952.1 - 0.12 12.0 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 Ldh_1_C PF02866.13 KOG98953.1 - 3.6e-51 173.3 0.0 5.2e-51 172.8 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 KOG98953.1 - 2.6e-45 153.7 0.3 4.1e-45 153.0 0.2 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain TRM13 PF05206.9 KOG98954.1 - 1.7e-76 256.8 0.6 2.4e-76 256.4 0.4 1.2 1 0 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.3 KOG98954.1 - 2.9e-12 45.7 2.2 6.6e-12 44.5 1.5 1.7 1 0 0 1 1 1 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.7 KOG98954.1 - 1.1e-11 44.1 0.8 2.4e-11 43.0 0.6 1.6 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger Methyltransf_32 PF13679.1 KOG98954.1 - 0.0022 17.6 2.1 0.018 14.7 1.5 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOG98954.1 - 0.058 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.13 KOG98955.1 - 3.7e-14 52.6 0.0 6.9e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 KOG98955.1 - 1.1e-06 28.6 0.0 2e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.13 KOG98955.1 - 0.032 13.6 0.0 1.1 8.6 0.0 2.3 2 0 0 2 2 2 0 DNA methylase MethyltransfD12 PF02086.10 KOG98955.1 - 0.18 11.2 5.8 3.5 7.0 0.1 3.7 3 1 0 4 4 4 0 D12 class N6 adenine-specific DNA methyltransferase RRM_1 PF00076.17 KOG98956.1 - 1.4e-36 123.9 0.3 9.2e-19 66.8 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG98956.1 - 7.6e-32 109.1 0.0 1e-15 57.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG98956.1 - 1.2e-10 41.0 0.0 0.00052 19.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.6 KOG98956.1 - 0.016 14.7 0.3 3.6 7.1 0.0 2.7 2 0 0 2 2 2 0 Ribonuclease B OB domain DUF2413 PF10310.4 KOG98956.1 - 9.2 4.9 20.9 19 3.9 14.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Nramp PF01566.13 KOG98957.1 - 2.5e-92 309.4 11.7 2.5e-92 309.4 8.1 1.5 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein Ribosomal_S19e PF01090.14 KOG98958.1 - 3.4e-38 130.2 0.1 3.7e-38 130.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e MFS_1 PF07690.11 KOG98959.1 - 1.4e-27 96.3 37.9 1.4e-27 96.3 26.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3789 PF12664.2 KOG98959.1 - 2.6 7.4 5.1 8.1 5.8 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3789) PCI PF01399.22 KOG98960.1 - 0.039 14.2 6.5 0.58 10.5 1.0 3.1 2 1 0 2 2 2 0 PCI domain GCR1_C PF12550.3 KOG98961.1 - 7.8e-25 86.5 0.3 1.6e-24 85.5 0.2 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes DUF4631 PF15450.1 KOG98961.1 - 0.032 12.5 0.5 0.048 11.9 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4631) DUF802 PF05650.6 KOG98961.1 - 0.084 13.0 1.1 0.14 12.3 0.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF802) SM-ATX PF14438.1 KOG98961.1 - 0.13 12.2 0.0 0.41 10.6 0.0 1.9 1 1 1 2 2 2 0 Ataxin 2 SM domain NTP_transf_2 PF01909.18 KOG98962.1 - 2e-17 63.2 0.9 1.5e-16 60.4 0.0 2.5 2 0 0 2 2 2 1 Nucleotidyltransferase domain PAP_assoc PF03828.14 KOG98962.1 - 7.4e-12 45.0 0.0 7.4e-12 45.0 0.0 2.1 2 0 0 2 2 2 1 Cid1 family poly A polymerase RD3 PF14473.1 KOG98962.1 - 0.0052 16.2 3.3 0.012 15.1 2.3 1.5 1 0 0 1 1 1 1 RD3 protein DNA_pol_B_palm PF14792.1 KOG98962.1 - 0.023 14.7 0.0 0.07 13.1 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase beta palm RF-1 PF00472.15 KOG98963.1 - 5.1e-13 48.8 0.1 1.2e-12 47.6 0.1 1.6 1 1 0 1 1 1 1 RF-1 domain MRP-S28 PF10213.4 KOG98963.1 - 0.016 15.3 0.1 0.022 14.8 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit protein Pkinase PF00069.20 KOG98964.1 - 2.3e-63 213.7 0.1 4.8e-63 212.7 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98964.1 - 8.4e-50 169.2 0.1 1.3e-49 168.5 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 KOG98964.1 - 7.1e-21 74.3 0.4 2.9e-20 72.4 0.0 2.2 2 0 0 2 2 2 1 P21-Rho-binding domain PH PF00169.24 KOG98964.1 - 6.2e-10 39.2 2.7 6.3e-10 39.1 0.4 2.1 3 0 0 3 3 3 1 PH domain Kinase-like PF14531.1 KOG98964.1 - 6.5e-07 28.5 0.2 4.5e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 Kinase-like PH_11 PF15413.1 KOG98964.1 - 5.7e-05 23.3 0.2 5.7e-05 23.3 0.1 2.3 2 1 0 2 2 2 1 Pleckstrin homology domain PAZ_siRNAbind PF12212.3 KOG98964.1 - 0.039 13.5 1.4 6.8 6.4 0.1 3.3 3 0 0 3 3 3 0 Piwi/Argonaute/Zwille siRNA-binding domain Kdo PF06293.9 KOG98964.1 - 0.054 12.5 0.0 0.13 11.3 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG98964.1 - 0.16 11.7 0.1 0.71 9.5 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family RabGAP-TBC PF00566.13 KOG98965.1 - 4e-44 150.6 0.1 1.3e-43 148.9 0.0 2.0 2 1 0 2 2 2 1 Rab-GTPase-TBC domain ubiquitin PF00240.18 KOG98966.1 - 2.4e-11 42.8 0.7 5.7e-11 41.6 0.3 1.8 1 1 1 2 2 2 1 Ubiquitin family Rad60-SLD_2 PF13881.1 KOG98966.1 - 3.1e-05 23.8 0.1 6.1e-05 22.8 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like CLU_N PF15044.1 KOG98966.1 - 0.0024 17.9 0.1 0.005 16.9 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term Rad60-SLD PF11976.3 KOG98966.1 - 0.0024 17.4 0.3 0.0076 15.9 0.1 1.9 1 1 1 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Erf4 PF10256.4 KOG98967.1 - 1.9e-23 82.5 0.0 2.5e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Apolipoprotein PF01442.13 KOG98968.1 - 0.00062 19.3 15.1 0.001 18.6 10.5 1.4 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Reo_sigmaC PF04582.7 KOG98968.1 - 0.086 12.0 2.1 0.11 11.7 1.4 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein OmpH PF03938.9 KOG98968.1 - 0.22 11.4 20.2 0.32 10.9 14.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Baculo_PEP_C PF04513.7 KOG98968.1 - 0.25 11.1 7.1 0.089 12.6 1.9 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DivIVA PF05103.8 KOG98968.1 - 0.4 10.7 18.1 0.55 10.2 12.4 1.4 1 1 0 1 1 1 0 DivIVA protein Lyase_8_N PF08124.6 KOG98968.1 - 0.49 9.2 7.8 0.59 8.9 5.4 1.1 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain DUF883 PF05957.8 KOG98968.1 - 0.56 10.6 12.2 3.3 8.1 8.4 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) CCDC84 PF14968.1 KOG98968.1 - 0.64 9.4 11.1 0.71 9.3 7.7 1.0 1 0 0 1 1 1 0 Coiled coil protein 84 Fzo_mitofusin PF04799.8 KOG98968.1 - 0.85 8.9 8.9 0.76 9.1 5.3 1.5 1 1 0 1 1 1 0 fzo-like conserved region Exonuc_VII_L PF02601.10 KOG98968.1 - 0.89 8.6 10.9 1.1 8.4 7.6 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.6 KOG98968.1 - 0.93 8.0 16.1 1.1 7.8 11.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Carbpep_Y_N PF05388.6 KOG98968.1 - 0.98 9.6 5.7 0.43 10.7 1.3 1.9 1 1 1 2 2 2 0 Carboxypeptidase Y pro-peptide DUF4407 PF14362.1 KOG98968.1 - 1.8 7.4 14.4 3 6.7 10.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF148 PF02520.12 KOG98968.1 - 2.1 8.1 16.1 1.7 8.4 10.5 1.4 1 1 0 1 1 1 0 Domain of unknown function DUF148 Prominin PF05478.6 KOG98968.1 - 2.9 5.2 7.7 3.4 5.0 5.4 1.1 1 0 0 1 1 1 0 Prominin MAT1 PF06391.8 KOG98968.1 - 3.5 7.1 17.1 3.7 7.0 11.9 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 ATP11 PF06644.6 KOG98968.1 - 4.2 6.7 15.0 4.7 6.6 10.4 1.1 1 0 0 1 1 1 0 ATP11 protein FLO_LFY PF01698.11 KOG98968.1 - 5.9 5.6 12.4 7.1 5.3 8.6 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein Effector_1 PF04518.7 KOG98968.1 - 5.9 5.7 14.9 7 5.5 10.3 1.1 1 0 0 1 1 1 0 Effector from type III secretion system CMV_1a PF12467.3 KOG98968.1 - 7.5 6.8 15.3 11 6.4 10.6 1.3 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family RRF PF01765.14 KOG98968.1 - 8.7 5.7 17.5 12 5.3 12.1 1.2 1 0 0 1 1 1 0 Ribosome recycling factor HLH PF00010.21 KOG98969.1 - 0.6 9.8 4.0 1.3 8.7 0.2 2.5 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain DUF1751 PF08551.5 KOG98970.1 - 3.3e-30 104.3 1.4 3.3e-30 104.3 1.0 2.4 3 0 0 3 3 3 1 Eukaryotic integral membrane protein (DUF1751) YrhC PF14143.1 KOG98970.1 - 0.059 13.3 0.1 0.39 10.6 0.0 2.4 2 0 0 2 2 2 0 YrhC-like protein MgtE PF01769.11 KOG98970.1 - 0.14 12.4 7.1 0.067 13.4 0.6 2.4 2 0 0 2 2 2 0 Divalent cation transporter WSC PF01822.14 KOG98971.1 - 9.4e-12 44.6 12.1 9.4e-12 44.6 8.4 2.8 2 1 0 2 2 2 1 WSC domain Syndecan PF01034.15 KOG98971.1 - 9.2e-06 25.2 0.0 2.4e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Syndecan domain SKG6 PF08693.5 KOG98971.1 - 0.0019 17.4 0.6 0.0019 17.4 0.4 2.5 2 0 0 2 2 2 1 Transmembrane alpha-helix domain EphA2_TM PF14575.1 KOG98971.1 - 0.1 12.9 0.1 0.42 11.0 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF2668 PF10873.3 KOG98971.1 - 0.12 12.5 0.3 0.12 12.5 0.2 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF2668) DUF605 PF04652.11 KOG98971.1 - 0.38 10.0 22.3 0.63 9.3 15.5 1.4 1 0 0 1 1 1 0 Vta1 like Sugar_tr PF00083.19 KOG98973.1 - 1.4e-146 488.6 32.4 2e-146 488.1 22.5 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG98973.1 - 1.4e-28 99.6 34.9 2.5e-26 92.2 18.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 KOG98973.1 - 9.1e-07 27.4 1.6 9.1e-07 27.4 1.1 1.9 2 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 KOG98973.1 - 0.00055 18.1 0.7 0.00055 18.1 0.5 2.0 2 0 0 2 2 2 1 Transmembrane secretion effector DUF1673 PF07895.6 KOG98973.1 - 2.6 7.5 11.4 0.54 9.7 3.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1673) PTS_2-RNA PF01885.11 KOG98974.1 - 1.8e-58 196.9 0.2 2.3e-58 196.5 0.1 1.0 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Pox_VLTF3 PF04947.9 KOG98974.1 - 0.045 13.2 1.7 0.094 12.2 1.2 1.5 1 0 0 1 1 1 0 Poxvirus Late Transcription Factor VLTF3 like PARP PF00644.15 KOG98974.1 - 0.046 13.1 0.2 0.098 12.0 0.1 1.5 1 1 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain HlyIII PF03006.15 KOG98975.1 - 1.4e-25 90.0 22.1 1.7e-25 89.7 15.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF1129 PF06570.6 KOG98975.1 - 5 6.3 11.1 0.32 10.2 0.1 2.9 1 1 3 4 4 4 0 Protein of unknown function (DUF1129) Pkinase PF00069.20 KOG98976.1 - 5.4e-63 212.5 0.0 1.3e-62 211.3 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG98976.1 - 6.4e-32 110.6 0.0 1.1e-31 109.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG98976.1 - 3.4e-08 32.7 0.0 7.6e-08 31.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG98976.1 - 0.009 15.0 0.0 0.019 14.0 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG98976.1 - 0.01 15.5 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_M16_C PF05193.16 KOG98977.1 - 3.2e-14 53.0 0.2 4.6e-12 46.0 0.0 3.7 4 0 0 4 4 4 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 KOG98977.1 - 9.4e-08 31.9 0.0 3.2e-07 30.1 0.0 1.9 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) tRNA-synt_1b PF00579.20 KOG98978.1 - 9.2e-20 70.9 0.0 8.6e-13 48.0 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) Methyltransf_23 PF13489.1 KOG98979.1 - 5.1e-20 71.8 0.0 7.3e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOG98979.1 - 1.9e-15 57.4 0.0 9.6e-15 55.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOG98979.1 - 1.4e-14 53.9 0.0 2.3e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOG98979.1 - 1.7e-13 50.8 0.0 3.9e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOG98979.1 - 8.1e-12 45.4 0.0 1.9e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOG98979.1 - 1.8e-09 37.8 0.0 9.5e-09 35.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.15 KOG98979.1 - 2.7e-08 33.2 0.0 3.8e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.8 KOG98979.1 - 3e-07 29.8 0.0 4.3e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 KOG98979.1 - 3.5e-07 29.7 0.0 5.6e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain NodS PF05401.6 KOG98979.1 - 1.8e-06 27.5 0.0 2.8e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_26 PF13659.1 KOG98979.1 - 6.5e-06 26.1 0.0 1.7e-05 24.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 KOG98979.1 - 1.8e-05 24.2 0.1 5.1e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.13 KOG98979.1 - 0.00042 19.4 0.0 0.00057 19.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.1 KOG98979.1 - 0.0007 19.2 0.0 0.0013 18.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.7 KOG98979.1 - 0.0014 17.5 0.0 0.0026 16.6 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase RrnaAD PF00398.15 KOG98979.1 - 0.023 13.7 0.0 0.041 12.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PCMT PF01135.14 KOG98979.1 - 0.025 14.0 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.6 KOG98979.1 - 0.032 12.9 0.0 0.05 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) CheR PF01739.13 KOG98979.1 - 0.07 12.4 0.0 1 8.6 0.0 2.2 1 1 0 2 2 2 0 CheR methyltransferase, SAM binding domain UvrD_C PF13361.1 KOG98980.1 - 1e-66 225.8 0.1 3.6e-66 224.0 0.1 1.8 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 KOG98980.1 - 1.3e-38 133.0 4.0 1.2e-19 70.7 0.4 2.7 2 1 1 3 3 3 2 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.1 KOG98980.1 - 9.9e-11 41.7 0.0 3.1e-10 40.1 0.0 1.9 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.13 KOG98980.1 - 1.2e-10 41.3 0.2 0.00023 20.7 0.0 3.1 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 KOG98980.1 - 6.8e-10 38.5 0.0 1.8e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_11 PF13086.1 KOG98980.1 - 1e-09 38.3 0.1 5.3e-07 29.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.4 KOG98980.1 - 0.0034 16.4 1.0 1 8.2 0.0 3.2 3 1 0 4 4 4 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 KOG98980.1 - 0.02 14.4 0.0 0.28 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain DEAD PF00270.24 KOG98980.1 - 0.087 12.3 0.1 0.31 10.4 0.0 1.9 2 0 0 2 2 2 0 DEAD/DEAH box helicase Rep_fac_C PF08542.6 KOG98981.1 - 2.3e-18 65.9 1.1 4.3e-17 61.8 0.1 2.7 3 0 0 3 3 3 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 KOG98981.1 - 3.1e-14 52.9 0.1 1.7e-11 44.0 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 KOG98981.1 - 4.7e-13 49.4 0.0 9.8e-13 48.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 KOG98981.1 - 4e-09 35.7 0.0 8.1e-06 24.7 0.0 2.5 1 1 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 KOG98981.1 - 1.3e-07 31.7 0.0 8.4e-06 25.8 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.1 KOG98981.1 - 5.1e-07 29.6 0.0 8.6e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOG98981.1 - 4.2e-06 26.9 0.3 0.0019 18.3 0.2 2.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOG98981.1 - 1.1e-05 24.5 0.1 5.5e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_3 PF07726.6 KOG98981.1 - 0.00012 21.7 0.0 0.00027 20.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.13 KOG98981.1 - 0.00021 20.9 0.0 0.00041 19.9 0.0 1.5 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_10 PF12846.2 KOG98981.1 - 0.00026 20.5 0.3 0.1 12.0 0.1 2.3 1 1 1 2 2 2 2 AAA-like domain NTPase_1 PF03266.10 KOG98981.1 - 0.00077 19.2 0.1 0.016 14.8 0.0 2.3 1 1 1 2 2 2 1 NTPase FtsK_SpoIIIE PF01580.13 KOG98981.1 - 0.002 17.6 0.0 0.0037 16.7 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family Mg_chelatase PF01078.16 KOG98981.1 - 0.0025 16.9 0.1 0.037 13.2 0.1 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 KOG98981.1 - 0.0034 17.1 0.0 0.0065 16.1 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain DNA_pol3_delta PF06144.8 KOG98981.1 - 0.0047 16.4 0.1 0.0086 15.6 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit NB-ARC PF00931.17 KOG98981.1 - 0.013 14.3 0.0 0.024 13.4 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain ArgK PF03308.11 KOG98981.1 - 0.018 13.8 0.1 0.16 10.7 0.0 2.3 2 1 1 3 3 3 0 ArgK protein AAA_11 PF13086.1 KOG98981.1 - 0.027 14.0 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain DEAD PF00270.24 KOG98981.1 - 0.063 12.7 0.1 0.57 9.6 0.0 2.3 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_18 PF13238.1 KOG98981.1 - 0.07 13.4 0.0 0.16 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KOG98981.1 - 0.1 12.2 0.1 0.39 10.3 0.0 1.9 1 1 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 KOG98981.1 - 0.13 12.4 0.1 0.26 11.4 0.0 1.7 1 1 0 1 1 1 0 RNA helicase Med28 PF11594.3 KOG98981.1 - 0.19 11.9 1.2 7.7 6.8 0.1 3.1 3 1 0 3 3 3 0 Mediator complex subunit 28 tRNA_m1G_MT PF01746.16 KOG98982.1 - 1.2e-44 152.1 0.2 2.2e-44 151.2 0.1 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase CI-B14_5a PF07347.7 KOG98982.1 - 0.057 13.1 0.3 0.7 9.6 0.2 2.3 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) PQ-loop PF04193.9 KOG98983.1 - 2.6e-39 132.5 21.6 1.4e-20 72.6 2.5 2.8 3 0 0 3 3 3 2 PQ loop repeat MutS_V PF00488.16 KOG98985.1 - 7.3e-98 326.6 0.0 1.3e-97 325.8 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 KOG98985.1 - 5.6e-34 117.7 3.6 6.1e-34 117.6 0.5 2.3 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.12 KOG98985.1 - 2.1e-25 89.3 0.2 7.3e-25 87.6 0.1 2.1 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.13 KOG98985.1 - 7.5e-19 67.7 1.0 2.7e-18 65.9 0.7 2.1 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.15 KOG98985.1 - 1.4e-09 37.9 0.2 6.2e-09 35.8 0.0 2.1 2 0 0 2 2 2 1 MutS domain I Fungal_trans PF04082.13 KOG98986.1 - 3.8e-37 127.5 5.2 3.8e-37 127.5 3.6 2.7 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG98986.1 - 5.5e-09 35.7 13.6 1.1e-08 34.8 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mit_KHE1 PF10173.4 KOG98986.1 - 0.18 11.6 5.3 0.13 12.0 1.1 2.5 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related DUF948 PF06103.6 KOG98986.1 - 5 7.0 7.5 1.9 8.4 0.1 3.5 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Thioredoxin PF00085.15 KOG98987.1 - 6.7e-11 41.7 0.0 1.8e-10 40.4 0.1 1.7 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.1 KOG98987.1 - 0.02 15.0 0.0 0.051 13.7 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like ERp29 PF07749.7 KOG98987.1 - 0.2 12.3 1.6 0.48 11.0 0.1 2.0 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain Thymopoietin PF08198.6 KOG98987.1 - 0.45 10.0 2.0 1.8 8.1 0.7 2.2 1 1 1 2 2 2 0 Thymopoietin protein DUF3337 PF11816.3 KOG98988.1 - 7.4e-85 285.2 6.7 7.4e-85 285.2 4.7 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF3337) WD40 PF00400.27 KOG98988.1 - 7.2e-10 38.3 5.5 0.04 13.7 0.0 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat CENP-S PF15630.1 KOG98989.1 - 1.5e-21 76.3 0.0 1.9e-21 76.0 0.0 1.1 1 0 0 1 1 1 1 Kinetochore component CENP-S CENP-T PF15511.1 KOG98989.1 - 4.5e-05 22.8 0.1 6.5e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T Bromo_TP PF07524.8 KOG98989.1 - 0.0009 18.9 0.0 0.0013 18.3 0.0 1.4 1 1 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.10 KOG98989.1 - 0.019 14.7 0.1 0.022 14.5 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit ADH_N PF08240.7 KOG98990.1 - 4.2e-30 103.7 0.5 1.3e-29 102.1 0.4 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOG98990.1 - 6.2e-30 103.4 1.5 9.1e-30 102.8 1.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KOG98990.1 - 8.2e-05 23.5 0.0 0.00018 22.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF221 PF02714.10 KOG98991.1 - 1.3e-104 349.5 15.8 1.3e-104 349.5 11.0 1.6 2 0 0 2 2 2 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 KOG98991.1 - 2.5e-39 134.3 1.7 2.5e-39 134.3 1.2 2.6 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 KOG98991.1 - 5.5e-27 93.5 0.8 1.1e-26 92.5 0.0 1.9 2 0 0 2 2 2 1 Phosphate metabolism protein DUF4463 PF14703.1 KOG98991.1 - 1.2e-12 48.1 2.6 2.5e-12 47.1 1.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) Telomerase_RBD PF12009.3 KOG98991.1 - 0.081 12.8 1.0 3.9 7.3 0.0 2.7 2 0 0 2 2 2 0 Telomerase ribonucleoprotein complex - RNA binding domain CENP-N PF05238.8 KOG98991.1 - 0.77 8.7 5.3 1.5 7.8 3.7 1.4 1 0 0 1 1 1 0 Kinetochore protein CHL4 like ATG19_autophagy PF12744.2 KOG98992.1 - 6.9e-70 234.9 0.1 1.1e-69 234.3 0.0 1.3 1 0 0 1 1 1 1 Autophagy protein Atg19, Atg8-binding ATG19_autophagy PF12744.2 KOG98993.1 - 2.4e-72 243.0 2.6 6.9e-72 241.5 0.3 2.6 2 1 0 2 2 2 1 Autophagy protein Atg19, Atg8-binding SSFA2_C PF14723.1 KOG98993.1 - 0.038 13.7 0.3 0.57 9.8 0.1 2.1 2 0 0 2 2 2 0 Sperm-specific antigen 2 C-terminus Trp_repressor PF01371.14 KOG98993.1 - 0.1 12.5 0.2 0.27 11.1 0.0 1.8 2 0 0 2 2 2 0 Trp repressor protein RasGAP PF00616.14 KOG98994.1 - 5e-42 143.7 7.1 6.2e-42 143.4 2.0 3.1 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RNase_T PF00929.19 KOG98995.1 - 5.4e-29 101.5 0.0 1e-28 100.6 0.0 1.5 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 KOG98995.1 - 0.0008 18.9 0.0 0.0029 17.1 0.0 2.0 1 1 0 1 1 1 1 3'-5' exonuclease TUG-UBL1 PF11470.3 KOG98996.1 - 2e-05 24.4 1.1 0.0026 17.6 0.1 3.2 3 0 0 3 3 3 2 GLUT4 regulating protein TUG RBD PF02196.10 KOG98996.1 - 0.00043 19.9 0.0 0.0012 18.5 0.0 1.7 1 0 0 1 1 1 1 Raf-like Ras-binding domain DUF2611 PF11022.3 KOG98997.1 - 2.3e-24 85.2 0.0 2.5e-24 85.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2611) Brix PF04427.13 KOG98998.1 - 5.8e-40 136.9 0.2 8.6e-40 136.4 0.2 1.2 1 0 0 1 1 1 1 Brix domain DUF468 PF04318.7 KOG98998.1 - 0.025 15.1 1.1 0.055 14.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF468) NatB_MDM20 PF09797.4 KOG98999.1 - 6.4e-71 238.9 10.0 6.4e-71 238.9 6.9 2.5 4 0 0 4 4 4 1 N-acetyltransferase B complex (NatB) non catalytic subunit ENT PF03735.9 KOG98999.1 - 0.0076 15.9 0.2 2.9 7.6 0.0 3.1 2 0 0 2 2 2 2 ENT domain TPR_16 PF13432.1 KOG98999.1 - 0.057 14.1 0.0 35 5.2 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOG98999.1 - 0.083 12.7 0.0 0.36 10.7 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat ABC_tran PF00005.22 KOG99000.1 - 3.5e-50 169.8 2.8 4.9e-24 85.1 0.0 2.8 3 0 0 3 3 2 2 ABC transporter ABC2_membrane PF01061.19 KOG99000.1 - 6.7e-40 136.4 36.3 5.6e-25 87.7 10.3 2.4 2 0 0 2 2 2 2 ABC-2 type transporter AAA_21 PF13304.1 KOG99000.1 - 3.9e-16 59.8 13.9 3.1e-06 27.3 0.1 5.1 4 1 1 5 5 5 4 AAA domain DUF258 PF03193.11 KOG99000.1 - 1.1e-09 37.6 1.0 0.00018 20.7 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 SMC_N PF02463.14 KOG99000.1 - 4.6e-09 35.8 2.2 4.5e-05 22.7 0.1 3.2 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 KOG99000.1 - 2e-08 34.4 0.6 0.00016 21.7 0.0 3.4 3 1 0 3 3 2 2 AAA domain AAA_17 PF13207.1 KOG99000.1 - 8.1e-08 33.1 0.0 0.024 15.4 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.1 KOG99000.1 - 1.1e-07 31.4 0.2 0.0082 15.5 0.0 4.5 5 0 0 5 5 5 1 AAA domain AAA_16 PF13191.1 KOG99000.1 - 2.8e-07 30.7 0.3 0.031 14.2 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.1 KOG99000.1 - 4.2e-07 30.3 0.5 0.015 15.5 0.0 3.3 3 0 0 3 3 2 2 AAA domain AAA_15 PF13175.1 KOG99000.1 - 1.1e-06 28.0 10.6 0.002 17.2 0.0 5.0 5 1 0 5 5 5 2 AAA ATPase domain AAA_29 PF13555.1 KOG99000.1 - 1.7e-06 27.4 3.0 0.047 13.2 0.5 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain NACHT PF05729.7 KOG99000.1 - 5.2e-05 22.9 0.1 0.032 13.9 0.1 2.6 2 0 0 2 2 2 1 NACHT domain AAA_10 PF12846.2 KOG99000.1 - 0.00026 20.5 3.3 0.32 10.3 0.1 2.4 2 0 0 2 2 2 2 AAA-like domain AAA_28 PF13521.1 KOG99000.1 - 0.00027 20.9 0.2 0.027 14.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 KOG99000.1 - 0.00027 20.8 0.4 0.33 10.9 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase T2SE PF00437.15 KOG99000.1 - 0.00044 19.2 0.2 0.1 11.4 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_19 PF13245.1 KOG99000.1 - 0.00047 19.8 0.1 0.059 13.1 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain Arch_ATPase PF01637.13 KOG99000.1 - 0.00049 19.8 0.0 0.21 11.2 0.0 2.7 2 0 0 2 2 2 1 Archaeal ATPase SbcCD_C PF13558.1 KOG99000.1 - 0.00058 19.7 0.5 1.9 8.4 0.0 3.3 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.1 KOG99000.1 - 0.00081 19.2 0.1 2 8.3 0.0 3.3 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.17 KOG99000.1 - 0.0015 18.7 0.3 1.6 8.9 0.0 2.7 2 0 0 2 2 2 1 RNA helicase KAP_NTPase PF07693.9 KOG99000.1 - 0.0019 17.2 0.0 0.43 9.5 0.0 2.4 2 0 0 2 2 2 1 KAP family P-loop domain FtsK_SpoIIIE PF01580.13 KOG99000.1 - 0.0025 17.3 2.4 0.021 14.2 0.1 2.5 3 0 0 3 3 2 1 FtsK/SpoIIIE family MobB PF03205.9 KOG99000.1 - 0.0032 17.1 2.0 0.94 9.1 0.1 2.7 3 0 0 3 3 2 1 Molybdopterin guanine dinucleotide synthesis protein B Adeno_IVa2 PF02456.10 KOG99000.1 - 0.0042 15.7 0.2 0.016 13.8 0.0 1.9 2 0 0 2 2 2 1 Adenovirus IVa2 protein cobW PF02492.14 KOG99000.1 - 0.005 16.2 1.5 0.49 9.8 0.2 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Pox_A32 PF04665.7 KOG99000.1 - 0.0058 15.9 0.3 0.067 12.4 0.1 2.3 2 0 0 2 2 2 1 Poxvirus A32 protein AAA PF00004.24 KOG99000.1 - 0.0062 16.7 1.0 3.2 7.9 0.0 3.6 4 1 0 4 4 2 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 KOG99000.1 - 0.009 15.7 0.2 15 5.2 0.0 3.5 3 0 0 3 3 3 0 NTPase Miro PF08477.8 KOG99000.1 - 0.0099 16.3 0.1 7.8 7.0 0.1 2.9 2 0 0 2 2 2 0 Miro-like protein UPF0079 PF02367.12 KOG99000.1 - 0.011 15.3 0.4 0.3 10.7 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 KOG99000.1 - 0.014 14.9 0.6 2.5 7.6 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 KOG99000.1 - 0.021 14.6 0.3 6.4 6.6 0.2 2.5 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 KOG99000.1 - 0.028 14.7 13.6 0.079 13.2 2.0 3.8 2 1 1 3 3 2 0 AAA domain AAA_5 PF07728.9 KOG99000.1 - 0.052 13.2 0.7 1.7 8.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PRK PF00485.13 KOG99000.1 - 0.085 12.3 0.8 7.2 6.1 0.1 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family DUF87 PF01935.12 KOG99000.1 - 0.11 12.3 12.5 1.2 8.9 0.2 4.0 3 1 1 4 4 4 0 Domain of unknown function DUF87 AAA_24 PF13479.1 KOG99000.1 - 0.12 11.9 1.6 11 5.4 0.3 2.5 2 0 0 2 2 2 0 AAA domain ABC_ATPase PF09818.4 KOG99000.1 - 0.31 9.5 0.6 0.94 7.9 0.1 1.8 2 0 0 2 2 2 0 Predicted ATPase of the ABC class Zeta_toxin PF06414.7 KOG99000.1 - 0.44 9.6 1.9 14 4.6 0.0 2.5 3 0 0 3 3 2 0 Zeta toxin ATP_bind_1 PF03029.12 KOG99000.1 - 0.58 9.6 3.5 14 5.0 0.8 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PCI PF01399.22 KOG99002.1 - 6.3e-19 68.2 0.9 8.2e-18 64.6 0.0 2.7 3 0 0 3 3 3 1 PCI domain Sdh5 PF03937.11 KOG99003.1 - 4.2e-25 87.2 0.7 7e-25 86.5 0.5 1.4 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase Nuf2 PF03800.9 KOG99005.1 - 9.3e-50 168.4 3.8 9.3e-50 168.4 2.6 2.1 2 0 0 2 2 2 1 Nuf2 family DASH_Dam1 PF08653.5 KOG99005.1 - 0.047 13.4 14.7 5.3 6.8 0.1 5.3 5 0 0 5 5 5 0 DASH complex subunit Dam1 Reo_sigmaC PF04582.7 KOG99005.1 - 0.41 9.7 8.4 0.34 10.0 4.3 1.8 1 1 0 2 2 2 0 Reovirus sigma C capsid protein SIR2 PF02146.12 KOG99006.1 - 1.8e-65 219.9 0.0 2.8e-65 219.3 0.0 1.3 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.8 KOG99006.1 - 3e-56 189.2 3.7 5.4e-56 188.3 2.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.17 KOG99006.1 - 0.00062 19.5 0.1 0.75 9.5 0.0 2.8 3 0 0 3 3 3 2 Thiamine pyrophosphate enzyme, central domain HLH PF00010.21 KOG99007.1 - 7.3e-18 64.0 0.0 1.3e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PseudoU_synth_2 PF00849.17 KOG99008.1 - 9.4e-32 110.1 0.1 9.4e-32 110.1 0.1 1.6 2 0 0 2 2 2 1 RNA pseudouridylate synthase dCMP_cyt_deam_1 PF00383.17 KOG99008.1 - 5.4e-17 61.3 0.1 1.2e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region S4 PF01479.20 KOG99008.1 - 0.14 11.6 0.0 0.3 10.5 0.0 1.6 1 0 0 1 1 1 0 S4 domain Exo_endo_phos PF03372.18 KOG99009.1 - 4.3e-19 69.4 0.0 5.1e-19 69.1 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 KOG99009.1 - 0.045 13.3 0.0 0.12 11.9 0.0 1.8 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase Inositol_P PF00459.20 KOG99010.1 - 1.5e-63 214.6 0.1 1.9e-62 211.0 0.1 1.9 1 1 0 1 1 1 1 Inositol monophosphatase family CRT10 PF08728.5 KOG99011.1 - 2.8e-261 868.6 4.5 3.2e-261 868.4 3.1 1.0 1 0 0 1 1 1 1 CRT10 Adap_comp_sub PF00928.16 KOG99012.1 - 4.6e-77 258.6 0.9 4.6e-77 258.6 0.6 1.5 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 KOG99012.1 - 0.00046 19.9 0.3 0.0031 17.2 0.0 2.1 2 0 0 2 2 2 1 Clathrin adaptor complex small chain Pribosyl_synth PF14572.1 KOG99013.1 - 7.6e-42 143.1 1.3 4.5e-41 140.6 0.9 2.0 1 1 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 KOG99013.1 - 2.1e-35 120.9 0.1 2e-34 117.8 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 KOG99013.1 - 9.1e-13 48.0 0.1 2.2e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF21 PF01595.15 KOG99014.1 - 5.2e-32 110.6 1.4 6.6e-32 110.2 0.3 1.6 2 0 0 2 2 2 1 Domain of unknown function DUF21 CBS PF00571.23 KOG99014.1 - 2.5e-05 23.9 0.0 0.042 13.6 0.0 2.6 2 0 0 2 2 2 2 CBS domain T4_Gp59_C PF08994.5 KOG99014.1 - 0.017 15.2 0.0 0.047 13.8 0.0 1.7 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase C-term NAD_Gly3P_dh_N PF01210.18 KOG99015.1 - 8.2e-53 178.3 0.0 1.4e-52 177.6 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.9 KOG99015.1 - 1.1e-48 164.7 0.1 1.6e-48 164.2 0.1 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.12 KOG99015.1 - 0.051 14.0 0.1 0.9 10.0 0.0 2.5 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.19 KOG99015.1 - 0.095 13.0 0.0 1.5 9.1 0.0 2.4 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Arginosuc_synth PF00764.14 KOG99016.1 - 3.8e-164 546.3 0.0 4.4e-164 546.1 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.16 KOG99016.1 - 5.6e-05 22.7 0.0 8.2e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.8 KOG99016.1 - 0.00022 20.5 0.0 0.00042 19.6 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 KOG99016.1 - 0.005 15.4 0.0 0.0073 14.9 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase Peptidase_M49 PF03571.10 KOG99017.1 - 2.1e-225 749.0 0.1 4.5e-225 747.9 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M49 Phos_pyr_kin PF08543.7 KOG99018.1 - 4.3e-78 261.9 0.1 5.3e-78 261.6 0.1 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.11 KOG99018.1 - 1.1e-69 234.4 0.5 1.5e-69 233.9 0.3 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.19 KOG99018.1 - 0.00021 20.5 0.0 0.00032 19.9 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase zf-C3HC4_4 PF15227.1 KOG99019.1 - 1.9e-09 37.2 10.6 1.9e-09 37.2 7.3 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 KOG99019.1 - 1.6e-08 34.0 9.8 1.6e-08 34.0 6.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOG99019.1 - 7.2e-08 32.3 9.8 7.2e-08 32.3 6.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOG99019.1 - 9.8e-08 31.5 13.1 6.1e-07 29.0 4.0 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOG99019.1 - 2e-07 30.5 3.1 4.6e-07 29.4 2.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.1 KOG99019.1 - 5.2e-07 29.3 9.1 5.2e-07 29.3 6.3 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 KOG99019.1 - 9e-06 25.3 8.5 9e-06 25.3 5.9 2.5 2 1 0 2 2 2 1 zinc-RING finger domain DZR PF12773.2 KOG99019.1 - 0.0012 18.5 9.5 0.18 11.6 0.2 2.6 2 0 0 2 2 2 2 Double zinc ribbon HypA PF01155.14 KOG99019.1 - 0.0023 17.5 4.8 0.067 12.8 0.0 2.3 1 1 1 2 2 2 1 Hydrogenase expression/synthesis hypA family zf-ribbon_3 PF13248.1 KOG99019.1 - 0.0046 16.1 3.3 0.023 13.8 0.5 2.7 2 0 0 2 2 2 1 zinc-ribbon domain zf-rbx1 PF12678.2 KOG99019.1 - 0.018 15.1 3.7 0.018 15.1 2.6 2.2 2 0 0 2 2 2 0 RING-H2 zinc finger NinF PF05810.7 KOG99019.1 - 0.02 14.6 1.4 0.02 14.6 0.9 2.8 3 0 0 3 3 1 0 NinF protein GldM_N PF12081.3 KOG99019.1 - 0.025 14.1 0.1 0.053 13.0 0.1 1.5 1 0 0 1 1 1 0 GldM N-terminal domain zinc_ribbon_2 PF13240.1 KOG99019.1 - 0.03 13.7 4.4 0.95 9.0 1.1 3.5 2 1 1 3 3 3 0 zinc-ribbon domain zf-RING_3 PF14369.1 KOG99019.1 - 0.038 14.0 17.4 0.12 12.3 2.1 3.8 3 1 1 4 4 4 0 zinc-finger Glucokinase PF02685.11 KOG99019.1 - 0.2 10.4 0.0 0.28 9.9 0.0 1.2 1 0 0 1 1 1 0 Glucokinase PhnA_Zn_Ribbon PF08274.7 KOG99019.1 - 0.7 9.7 6.7 14 5.5 0.1 4.0 4 0 0 4 4 4 0 PhnA Zinc-Ribbon zf-Apc11 PF12861.2 KOG99019.1 - 0.71 9.7 8.0 0.048 13.4 1.8 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-CHY PF05495.7 KOG99019.1 - 0.87 9.7 10.9 4.5 7.5 0.1 3.0 2 1 0 2 2 2 0 CHY zinc finger Zn_Tnp_IS1595 PF12760.2 KOG99019.1 - 0.92 9.3 7.2 2.1 8.2 0.1 3.2 3 0 0 3 3 3 0 Transposase zinc-ribbon domain Zn-ribbon_8 PF09723.5 KOG99019.1 - 2.1 8.3 11.7 1.2 9.1 0.7 3.4 2 1 1 3 3 3 0 Zinc ribbon domain RNHCP PF12647.2 KOG99019.1 - 2.8 7.8 9.2 0.88 9.4 0.2 3.1 2 1 0 2 2 2 0 RNHCP domain zf-RING_4 PF14570.1 KOG99019.1 - 5.2 6.7 19.5 3.4 7.3 6.1 3.3 2 2 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-MIZ PF02891.15 KOG99019.1 - 5.8 6.5 16.6 0.1 12.1 5.4 2.1 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger DUF2296 PF10058.4 KOG99019.1 - 6 6.6 9.8 41 4.0 0.1 4.3 3 1 1 4 4 4 0 Predicted integral membrane metal-binding protein (DUF2296) zinc-ribbons_6 PF07191.7 KOG99019.1 - 6.4 6.6 11.0 3.4 7.5 0.3 2.6 2 1 0 2 2 2 0 zinc-ribbons Colicin_V PF02674.11 KOG99020.1 - 0.052 13.4 0.0 0.076 12.8 0.0 1.2 1 0 0 1 1 1 0 Colicin V production protein Transgly_assoc PF04226.8 KOG99021.1 - 1.7 8.7 6.5 0.47 10.5 2.5 1.5 2 0 0 2 2 2 0 Transglycosylase associated protein SAM_decarbox PF01536.11 KOG99022.1 - 2.3e-123 411.0 2.7 2.7e-123 410.8 1.9 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Tbf5 PF06331.7 KOG99022.1 - 0.15 11.8 0.6 7.7 6.3 0.0 3.4 4 0 0 4 4 4 0 Transcription factor TFIIH complex subunit Tfb5 Med15_fungi PF05397.7 KOG99023.1 - 3e-39 133.5 5.3 3e-39 133.5 3.7 7.4 5 2 2 7 7 7 1 Mediator complex subunit 15 GSH_synth_ATP PF03917.12 KOG99024.1 - 9.7e-139 462.0 0.1 1.1e-138 461.8 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 KOG99024.1 - 2.3e-37 127.2 0.1 4.2e-37 126.4 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Pkinase PF00069.20 KOG99025.1 - 2.8e-60 203.6 0.1 5.3e-60 202.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99025.1 - 1.3e-22 80.0 0.0 2.2e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG99025.1 - 2.5e-10 39.8 0.0 4.3e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PAS PF00989.19 KOG99025.1 - 7.8e-05 22.4 0.0 0.62 9.8 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.1 KOG99025.1 - 0.00095 19.5 0.0 0.83 10.0 0.0 2.8 2 0 0 2 2 2 2 PAS domain Kdo PF06293.9 KOG99025.1 - 0.0014 17.7 0.1 0.0028 16.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG99025.1 - 0.0021 17.8 0.1 0.0052 16.5 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family NETI PF14044.1 KOG99026.1 - 0.14 11.7 0.2 0.62 9.6 0.0 2.2 2 0 0 2 2 2 0 NETI protein HhH-GPD PF00730.20 KOG99027.1 - 6.9e-20 71.3 0.0 1.1e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 KOG99027.1 - 0.0017 17.9 0.0 0.0063 16.1 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif Exo_endo_phos PF03372.18 KOG99028.1 - 2.9e-17 63.4 0.1 3.7e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RRM_1 PF00076.17 KOG99029.1 - 3.4e-20 71.4 2.7 7.2e-15 54.3 0.1 4.7 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG99029.1 - 9.9e-14 51.0 0.3 1.6e-10 40.7 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG99029.1 - 4.1e-13 48.9 1.7 5.9e-07 29.2 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KOG99029.1 - 0.0032 17.1 0.1 0.4 10.4 0.0 3.0 2 1 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Ribosomal_S19 PF00203.16 KOG99030.1 - 2.9e-32 110.1 0.4 6.2e-32 109.0 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein S19 DUF86 PF01934.12 KOG99030.1 - 0.13 11.9 0.0 2.5 7.7 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF86 Ribosomal_60s PF00428.14 KOG99031.1 - 1.3e-24 86.4 14.1 1.5e-24 86.2 9.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Sugar-bind PF04198.8 KOG99031.1 - 0.0055 15.6 0.1 0.0069 15.3 0.1 1.2 1 0 0 1 1 1 1 Putative sugar-binding domain DREPP PF05558.7 KOG99031.1 - 0.36 10.6 5.4 0.45 10.3 3.7 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Proteasome PF00227.21 KOG99032.1 - 7.4e-57 191.7 0.0 9.5e-57 191.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KOG99032.1 - 6.2e-14 51.0 0.1 1.4e-13 49.8 0.0 1.7 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature STAS PF01740.16 KOG99032.1 - 0.0054 16.1 0.2 0.015 14.7 0.1 1.8 2 0 0 2 2 2 1 STAS domain APC_CDC26 PF10471.4 KOG99032.1 - 0.61 10.8 5.1 1.2 9.9 3.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 DUF956 PF06115.6 KOG99033.1 - 0.015 14.8 0.4 0.12 11.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF956) SMC_N PF02463.14 KOG99034.1 - 7.3e-27 94.0 5.7 1.3e-26 93.1 4.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KOG99034.1 - 5.4e-10 39.9 41.8 5.4e-10 39.9 29.0 5.3 2 2 1 3 3 3 1 AAA domain AAA_21 PF13304.1 KOG99034.1 - 4.3e-07 30.1 0.6 4.3e-07 30.1 0.4 4.0 2 2 2 4 4 4 1 AAA domain AAA_29 PF13555.1 KOG99034.1 - 0.0002 20.8 0.0 0.00045 19.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 KOG99034.1 - 0.004 16.5 0.2 0.038 13.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain TMF_TATA_bd PF12325.3 KOG99034.1 - 0.0058 16.3 13.2 0.0058 16.3 9.2 6.5 2 2 4 7 7 7 1 TATA element modulatory factor 1 TATA binding Phe_tRNA-synt_N PF02912.13 KOG99034.1 - 0.0078 15.9 2.6 0.0078 15.9 1.8 3.7 5 0 0 5 5 5 1 Aminoacyl tRNA synthetase class II, N-terminal domain AAA_10 PF12846.2 KOG99034.1 - 0.25 10.7 0.0 0.25 10.7 0.0 4.2 3 2 0 3 3 3 0 AAA-like domain DUF3584 PF12128.3 KOG99034.1 - 1.4 6.1 71.1 0.31 8.3 3.7 4.1 2 2 2 4 4 4 0 Protein of unknown function (DUF3584) ApoO PF09769.4 KOG99034.1 - 4.3 7.0 11.2 0.24 11.1 0.9 3.5 3 1 0 3 3 3 0 Apolipoprotein O tRNA-synt_1c PF00749.16 KOG99035.1 - 4e-118 393.6 0.0 5.2e-118 393.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain DUF775 PF05603.7 KOG99036.1 - 3.7e-60 202.9 0.0 4.2e-60 202.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) ABC2_membrane_3 PF12698.2 KOG99037.1 - 9.9 5.0 7.3 0.63 9.0 0.8 1.9 2 0 0 2 2 2 0 ABC-2 family transporter protein Glyco_hydro_72 PF03198.9 KOG99038.1 - 5.4e-144 478.9 9.8 7.5e-144 478.4 6.8 1.2 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.13 KOG99038.1 - 2.7e-06 26.8 0.2 4.5e-05 22.7 0.1 2.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.12 KOG99038.1 - 6.1e-05 22.0 0.3 0.00013 21.0 0.2 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Nop14 PF04147.7 KOG99038.1 - 0.03 12.2 3.9 0.038 11.9 2.7 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4614 PF15391.1 KOG99038.1 - 0.33 10.6 17.0 0.72 9.5 11.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Macoilin PF09726.4 KOG99038.1 - 3.1 5.9 15.1 4 5.5 10.4 1.1 1 0 0 1 1 1 0 Transmembrane protein Na_trans_assoc PF06512.8 KOG99038.1 - 5.5 6.8 8.9 9 6.1 6.1 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated DUF515 PF04415.7 KOG99038.1 - 5.9 5.0 23.0 11 4.1 16.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF572 PF04502.8 KOG99038.1 - 6 5.9 10.6 9.1 5.3 7.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Apt1 PF10351.4 KOG99038.1 - 6.7 5.4 15.7 10 4.8 10.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain CDC45 PF02724.9 KOG99038.1 - 9.9 4.0 11.6 14 3.5 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Hap4_Hap_bind PF10297.4 KOG99039.1 - 1.6e-08 34.1 1.6 3.1e-08 33.1 1.1 1.5 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.16 KOG99039.1 - 4.8e-08 32.8 6.6 2.1e-07 30.8 4.6 2.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 KOG99039.1 - 6.9e-05 22.5 6.3 0.00026 20.7 4.4 2.0 1 0 0 1 1 1 1 Basic region leucine zipper CR6_interact PF10147.4 KOG99039.1 - 0.002 17.5 2.9 0.006 15.9 2.0 1.8 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 bZIP_Maf PF03131.12 KOG99039.1 - 0.0065 16.7 7.8 0.014 15.6 5.0 1.9 1 1 0 1 1 1 1 bZIP Maf transcription factor EAP30 PF04157.11 KOG99039.1 - 0.034 13.2 1.1 0.069 12.3 0.5 1.6 1 1 0 1 1 1 0 EAP30/Vps36 family Striatin PF08232.7 KOG99039.1 - 0.89 9.8 9.9 0.73 10.1 4.6 2.7 1 1 1 2 2 2 0 Striatin family ADIP PF11559.3 KOG99039.1 - 2 8.2 12.1 0.29 11.0 4.9 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding LETM1 PF07766.8 KOG99040.1 - 1.2e-105 352.3 7.2 2.3e-105 351.4 5.0 1.4 1 0 0 1 1 1 1 LETM1-like protein TOM13 PF08219.6 KOG99041.1 - 3e-30 103.7 0.0 3.8e-30 103.4 0.0 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 TIP120 PF08623.5 KOG99042.1 - 0.0009 18.8 0.4 0.0049 16.4 0.3 2.4 1 0 0 1 1 1 1 TATA-binding protein interacting (TIP20) Crystall_3 PF08964.5 KOG99043.1 - 0.014 15.0 0.1 0.029 14.0 0.1 1.4 1 0 0 1 1 1 0 Beta/Gamma crystallin GTP_EFTU PF00009.22 KOG99044.1 - 8.8e-35 119.8 6.1 2.9e-34 118.1 3.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 KOG99044.1 - 8.7e-24 83.5 0.6 2.7e-23 81.9 0.4 1.9 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 KOG99044.1 - 4.5e-10 39.5 0.3 1.1e-05 25.4 0.0 3.0 2 0 0 2 2 2 2 Elongation factor Tu domain 2 IF2_N PF04760.10 KOG99044.1 - 1.7e-08 33.9 0.2 5.8e-08 32.2 0.0 2.1 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region MMR_HSR1 PF01926.18 KOG99044.1 - 1.6e-06 28.0 1.0 3.4e-06 27.0 0.2 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 KOG99044.1 - 1.9e-05 25.1 0.2 7e-05 23.3 0.1 2.0 1 0 0 1 1 1 1 Miro-like protein FeoB_N PF02421.13 KOG99044.1 - 0.0016 17.6 0.5 0.0064 15.7 0.4 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.17 KOG99044.1 - 0.0019 17.5 1.0 0.0041 16.5 0.0 2.1 2 1 0 2 2 2 1 Ras family Dynamin_N PF00350.18 KOG99044.1 - 0.076 12.8 8.0 2.5 7.9 0.1 3.9 4 1 1 5 5 5 0 Dynamin family PDCD2_C PF04194.8 KOG99045.1 - 2.4e-38 131.3 6.4 3.6e-38 130.7 0.0 3.0 2 1 1 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain RNB PF00773.14 KOG99046.1 - 4.1e-94 315.4 0.0 6.6e-94 314.8 0.0 1.3 1 0 0 1 1 1 1 RNB domain PIN_4 PF13638.1 KOG99046.1 - 3.3e-14 53.1 0.3 8.2e-14 51.8 0.2 1.7 1 0 0 1 1 1 1 PIN domain AA_permease PF00324.16 KOG99047.1 - 3.2e-118 395.1 41.9 3.9e-118 394.8 29.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG99047.1 - 4.4e-31 107.8 43.9 5.6e-31 107.5 30.5 1.1 1 0 0 1 1 1 1 Amino acid permease SUR7 PF06687.7 KOG99048.1 - 8e-19 68.0 18.8 1.2e-18 67.4 13.0 1.2 1 0 0 1 1 1 1 SUR7/PalI family SNARE PF05739.14 KOG99049.1 - 3.3e-19 68.3 5.0 4.7e-18 64.6 1.8 3.0 3 0 0 3 3 3 1 SNARE domain Plasmodium_Vir PF05795.6 KOG99049.1 - 0.00034 19.9 8.4 0.00051 19.3 5.8 1.2 1 0 0 1 1 1 1 Plasmodium vivax Vir protein DUF3357 PF11837.3 KOG99049.1 - 0.0017 18.1 0.1 0.0052 16.6 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3357) DUF1980 PF09323.5 KOG99049.1 - 0.0021 17.8 1.3 0.0021 17.8 0.9 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1980) Menin PF05053.8 KOG99049.1 - 0.047 11.8 1.0 0.056 11.6 0.7 1.2 1 0 0 1 1 1 0 Menin Serinc PF03348.10 KOG99049.1 - 0.15 10.7 0.5 0.23 10.1 0.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Dsh_C PF12316.3 KOG99049.1 - 0.46 10.5 5.3 1.2 9.2 3.7 1.6 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF4239 PF14023.1 KOG99049.1 - 5.1 6.3 6.0 53 3.0 4.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4239) WHIM1 PF15612.1 KOG99050.1 - 0.00098 18.9 1.0 0.0017 18.2 0.0 1.9 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 Pkinase PF00069.20 KOG99051.1 - 5.3e-70 235.5 0.0 7.6e-70 235.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99051.1 - 1.6e-38 132.2 0.0 2.6e-38 131.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG99051.1 - 0.0052 15.7 0.0 0.044 12.7 0.0 2.2 2 1 0 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.4 KOG99051.1 - 0.052 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pox_ser-thr_kin PF05445.6 KOG99051.1 - 0.06 12.1 0.9 0.12 11.1 0.1 1.8 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase zf-RING_2 PF13639.1 KOG99054.1 - 7.5e-13 48.0 5.7 1.5e-12 47.1 4.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOG99054.1 - 5.5e-10 39.2 6.0 1.1e-09 38.2 4.1 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 KOG99054.1 - 2.4e-08 33.5 4.8 4.3e-08 32.7 3.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOG99054.1 - 3.2e-08 33.0 3.8 6.1e-08 32.2 2.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOG99054.1 - 5.3e-07 29.5 6.7 3.7e-06 26.8 4.6 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOG99054.1 - 4.7e-05 22.9 8.0 4.7e-05 22.9 5.5 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOG99054.1 - 0.0011 18.6 6.5 0.0098 15.5 4.6 2.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 KOG99054.1 - 0.013 15.3 1.7 0.013 15.3 1.2 2.9 4 0 0 4 4 4 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.1 KOG99054.1 - 0.028 13.9 0.3 0.068 12.7 0.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-Apc11 PF12861.2 KOG99054.1 - 0.066 13.0 4.7 0.17 11.7 3.2 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.2 KOG99054.1 - 0.6 10.2 7.3 2.1 8.4 5.0 1.9 1 1 0 1 1 1 0 RING-variant domain zf-P11 PF03854.9 KOG99054.1 - 1 8.9 6.2 0.17 11.3 1.4 1.9 2 0 0 2 2 2 0 P-11 zinc finger FANCL_C PF11793.3 KOG99054.1 - 1.5 8.8 5.7 1.7 8.6 2.7 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain Histone PF00125.19 KOG99055.1 - 1.7e-22 79.3 0.1 2.1e-22 78.9 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KOG99055.1 - 0.00018 21.5 0.0 0.00024 21.1 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PLA2_B PF01735.13 KOG99056.1 - 9.8e-231 766.1 1.5 1.2e-230 765.8 1.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain RTC PF01137.16 KOG99057.1 - 4.2e-61 205.6 0.0 4.9e-61 205.4 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.8 KOG99057.1 - 2.9e-29 101.1 0.0 4.9e-29 100.3 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain DUF2404 PF10296.4 KOG99058.1 - 0.005 16.9 0.0 0.019 15.0 0.0 1.9 2 0 0 2 2 2 1 Putative integral membrane protein conserved region (DUF2404) Polyketide_cyc PF03364.15 KOG99059.1 - 2.5e-16 59.8 0.0 3e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Herpes_gE PF02480.11 KOG99060.1 - 0.0062 14.8 0.2 0.014 13.6 0.0 1.6 1 1 0 2 2 2 1 Alphaherpesvirus glycoprotein E Topoisom_I_N PF02919.10 KOG99061.1 - 2.3e-101 337.5 0.8 2.3e-101 337.5 0.5 3.5 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.15 KOG99061.1 - 6e-86 287.3 1.5 6e-86 287.3 1.0 3.0 4 0 0 4 4 4 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 KOG99061.1 - 3.2e-33 113.2 0.8 3.2e-33 113.2 0.5 2.4 2 0 0 2 2 2 1 C-terminal topoisomerase domain RNA_pol_L_2 PF13656.1 KOG99062.1 - 1.1e-25 88.8 0.0 1.4e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 KOG99062.1 - 4.8e-12 44.8 0.0 6.5e-12 44.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Thymidylate_kin PF02223.12 KOG99062.1 - 0.11 11.8 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Thymidylate kinase PAH PF02671.16 KOG99063.1 - 2.5e-46 155.0 8.0 2.2e-19 68.7 0.7 4.3 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.7 KOG99063.1 - 9.4e-44 147.3 0.7 3.4e-43 145.4 0.2 2.3 2 0 0 2 2 2 1 Sin3 family co-repressor zf-DHHC PF01529.15 KOG99064.1 - 2.5e-30 105.1 17.2 2.5e-30 105.1 11.9 2.0 1 1 1 2 2 2 1 DHHC palmitoyltransferase HlyIII PF03006.15 KOG99065.1 - 3.7e-52 176.9 20.7 4.4e-52 176.6 14.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF4401 PF14351.1 KOG99065.1 - 0.005 15.8 8.4 0.0075 15.2 1.9 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4401) DUF4199 PF13858.1 KOG99065.1 - 1.5 8.7 9.6 0.49 10.3 2.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4199) Cyclin PF08613.6 KOG99066.1 - 3.7e-39 134.5 1.4 3.7e-39 134.5 1.0 1.6 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.18 KOG99066.1 - 0.019 14.5 0.0 0.041 13.4 0.0 1.6 1 0 0 1 1 1 0 Cyclin, N-terminal domain HU-DNA_bdg PF14848.1 KOG99066.1 - 0.11 12.1 0.1 0.42 10.3 0.0 1.9 2 0 0 2 2 2 0 DNA-binding domain DNA_pol_A_exo1 PF01612.15 KOG99067.1 - 3.7e-48 163.3 2.3 1.3e-47 161.4 0.3 2.3 2 0 0 2 2 2 1 3'-5' exonuclease PMC2NT PF08066.7 KOG99067.1 - 3.1e-25 88.3 9.5 7.8e-25 86.9 2.0 3.3 3 0 0 3 3 3 1 PMC2NT (NUC016) domain HRDC PF00570.18 KOG99067.1 - 1.5e-11 43.8 0.0 3.1e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 HRDC domain Mer2 PF09074.5 KOG99067.1 - 0.0092 15.9 0.8 0.0092 15.9 0.6 2.8 3 0 0 3 3 3 1 Mer2 Alg6_Alg8 PF03155.10 KOG99068.1 - 1.5e-178 594.4 32.7 1.7e-178 594.2 22.7 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Peptidase_S8 PF00082.17 KOG99069.1 - 1.8e-53 181.5 1.2 2.4e-53 181.1 0.9 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 KOG99069.1 - 5.2e-09 36.5 0.0 1.4e-08 35.1 0.0 1.8 1 0 0 1 1 1 1 Peptidase inhibitor I9 Fcf1 PF04900.7 KOG99070.1 - 2.7e-32 110.8 2.7 3.8e-32 110.3 0.3 2.2 2 0 0 2 2 2 1 Fcf1 SCHIP-1 PF10148.4 KOG99070.1 - 0.12 11.7 4.6 0.21 10.9 3.2 1.3 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 CDC45 PF02724.9 KOG99070.1 - 0.32 8.9 4.5 0.39 8.6 3.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_ligase_A_M PF01068.16 KOG99071.1 - 3.4e-51 173.5 0.0 6.1e-51 172.6 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 KOG99071.1 - 3e-13 49.9 0.0 6.4e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus BRCT PF00533.21 KOG99071.1 - 3.1e-10 40.0 0.9 3.9e-05 23.7 0.0 2.8 2 1 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain DNA_ligase_A_C PF04679.10 KOG99071.1 - 1.9e-05 24.9 0.0 4.5e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region mRNA_cap_enzyme PF01331.14 KOG99071.1 - 0.00039 20.1 0.4 0.38 10.4 0.0 2.6 2 0 0 2 2 2 2 mRNA capping enzyme, catalytic domain Fve PF09259.6 KOG99071.1 - 0.0026 17.6 0.0 0.42 10.5 0.0 2.6 2 0 0 2 2 2 1 Fungal immunomodulatory protein Fve DUF367 PF04034.8 KOG99072.1 - 7.8e-55 183.9 0.0 1.1e-54 183.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 KOG99072.1 - 1e-15 56.9 0.3 1.8e-15 56.2 0.2 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI TPR_11 PF13414.1 KOG99073.1 - 1.8e-22 78.7 8.7 1.5e-17 63.0 1.7 3.0 1 1 1 3 3 3 2 TPR repeat TPR_1 PF00515.23 KOG99073.1 - 8.3e-19 66.3 6.1 4.8e-07 29.1 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOG99073.1 - 1.9e-16 58.5 7.4 1.7e-05 24.3 0.1 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOG99073.1 - 1.3e-10 41.6 11.2 2.9e-06 27.7 1.0 2.8 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOG99073.1 - 6.3e-09 35.6 5.1 2e-07 30.8 0.5 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOG99073.1 - 1.9e-08 33.8 0.7 0.0016 18.4 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOG99073.1 - 4.7e-07 29.8 0.2 0.035 14.7 0.0 3.5 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOG99073.1 - 1.8e-06 28.2 4.0 0.018 15.3 0.1 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOG99073.1 - 7.4e-06 25.3 9.4 0.023 14.4 0.1 3.7 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOG99073.1 - 1.5e-05 24.4 2.9 0.83 9.6 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat BTAD PF03704.12 KOG99073.1 - 0.00064 20.0 0.1 0.0029 17.9 0.0 2.0 1 1 1 2 2 2 1 Bacterial transcriptional activator domain TPR_6 PF13174.1 KOG99073.1 - 0.002 18.4 2.4 0.061 13.8 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOG99073.1 - 0.0032 17.3 0.7 2.2 8.3 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOG99073.1 - 0.0097 15.7 0.0 0.05 13.4 0.0 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOG99073.1 - 0.015 15.1 2.5 2.6 7.9 0.1 3.6 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Apc3 PF12895.2 KOG99073.1 - 0.015 15.3 2.3 0.07 13.2 1.3 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3856 PF12968.2 KOG99073.1 - 0.018 14.8 1.3 0.09 12.5 0.4 2.4 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) MIT PF04212.13 KOG99073.1 - 1.2 9.0 13.1 1.3 9.0 0.2 4.0 2 2 2 4 4 4 0 MIT (microtubule interacting and transport) domain WSC PF01822.14 KOG99074.1 - 3.5e-13 49.2 15.0 3.5e-13 49.2 10.4 3.0 2 1 0 2 2 1 1 WSC domain TMEM154 PF15102.1 KOG99074.1 - 0.0014 18.3 0.3 0.0014 18.3 0.2 2.5 1 1 1 2 2 1 1 TMEM154 protein family DUF4514 PF14986.1 KOG99074.1 - 0.021 14.6 0.4 0.045 13.5 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4514) Gly-zipper_Omp PF13488.1 KOG99074.1 - 0.043 13.4 10.9 0.085 12.5 7.6 1.4 1 0 0 1 1 1 0 Glycine zipper Yip1 PF04893.12 KOG99074.1 - 0.049 13.1 0.2 0.085 12.3 0.1 1.4 1 0 0 1 1 1 0 Yip1 domain Macoilin PF09726.4 KOG99074.1 - 0.085 11.1 17.6 0.1 10.8 12.2 1.4 1 0 0 1 1 1 0 Transmembrane protein Gly-zipper_YMGG PF13441.1 KOG99074.1 - 0.086 12.3 8.2 0.17 11.4 5.7 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper EphA2_TM PF14575.1 KOG99074.1 - 0.15 12.4 2.1 0.19 12.1 0.0 2.2 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Sec3_C PF09763.4 KOG99074.1 - 0.24 9.4 5.7 0.3 9.1 4.0 1.3 1 0 0 1 1 1 0 Exocyst complex component Sec3 Rifin_STEVOR PF02009.11 KOG99074.1 - 0.65 9.5 11.1 2.6 7.5 7.7 1.9 1 1 0 1 1 1 0 Rifin/stevor family ABC2_membrane_3 PF12698.2 KOG99074.1 - 0.67 8.9 8.3 1.3 8.0 5.8 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein CCDC84 PF14968.1 KOG99074.1 - 3.4 7.0 11.2 5.3 6.4 7.8 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 Bacteriocin_IIc PF10439.4 KOG99074.1 - 3.9 7.6 11.7 0.25 11.5 4.3 1.8 2 0 0 2 2 1 0 Bacteriocin class II with double-glycine leader peptide DUF566 PF04484.7 KOG99074.1 - 6.3 6.2 20.8 11 5.4 14.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF566) Beta-APP PF03494.8 KOG99074.1 - 7 6.2 8.0 20 4.7 5.6 1.8 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) SRP1_TIP1 PF00660.12 KOG99075.1 - 5.5e-38 128.9 0.5 2.3e-37 126.9 0.3 2.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family SRP1_TIP1 PF00660.12 KOG99076.1 - 1.5e-38 130.8 0.5 4.8e-38 129.1 0.3 1.8 1 0 0 1 1 1 1 Seripauperin and TIP1 family PIR PF00399.14 KOG99076.1 - 2.7e-08 32.8 6.9 3.5e-07 29.3 4.8 3.2 1 0 0 1 1 1 1 Yeast PIR protein repeat Spc42p PF11544.3 KOG99076.1 - 0.09 12.7 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Spindle pole body component Spc42p SLD3 PF08639.5 KOG99076.1 - 2.7 6.5 13.4 3.7 6.0 9.3 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 CytochromB561_N PF09786.4 KOG99076.1 - 2.9 6.2 19.7 3.2 6.0 13.6 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal SOBP PF15279.1 KOG99076.1 - 5.6 7.2 9.8 9.2 6.5 6.8 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein Hex_IIIa PF02455.11 KOG99076.1 - 6.9 5.2 13.3 32 3.0 0.0 2.1 2 0 0 2 2 2 0 Hexon-associated protein (IIIa) FAM196 PF15265.1 KOG99076.1 - 9 5.3 15.2 12 4.9 10.5 1.1 1 0 0 1 1 1 0 FAM196 family ABC2_membrane PF01061.19 KOG99077.1 - 1.6e-65 220.1 63.9 1.2e-35 122.6 19.9 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.22 KOG99077.1 - 9.6e-30 103.6 0.0 6.6e-15 55.6 0.1 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.7 KOG99077.1 - 8.7e-28 96.0 14.5 3.8e-24 84.3 0.0 3.4 3 0 0 3 3 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.2 KOG99077.1 - 5e-13 48.7 45.3 2e-08 33.6 4.9 3.3 2 1 0 2 2 2 2 ABC-2 family transporter protein DUF258 PF03193.11 KOG99077.1 - 5e-05 22.5 0.1 9e-05 21.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_21 PF13304.1 KOG99077.1 - 0.00032 20.7 17.7 0.054 13.4 0.1 4.8 3 2 2 5 5 5 2 AAA domain AAA_18 PF13238.1 KOG99077.1 - 0.00097 19.4 0.0 0.0036 17.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.14 KOG99077.1 - 0.0071 15.5 0.7 0.39 9.9 0.0 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain cobW PF02492.14 KOG99077.1 - 0.014 14.8 0.1 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.1 KOG99077.1 - 0.015 15.3 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 KOG99077.1 - 0.029 14.4 0.0 0.079 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 KOG99077.1 - 0.035 14.4 0.3 0.035 14.4 0.2 2.1 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 KOG99077.1 - 0.049 13.1 0.5 0.13 11.8 0.4 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.1 KOG99077.1 - 0.12 11.7 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 KOG99077.1 - 0.14 11.8 0.0 0.34 10.6 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain T2SE PF00437.15 KOG99077.1 - 0.44 9.3 0.0 0.72 8.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein B56 PF01603.15 KOG99079.1 - 8.3e-146 485.7 25.5 4.4e-140 466.9 8.1 2.4 3 0 0 3 3 3 2 Protein phosphatase 2A regulatory B subunit (B56 family) EMP24_GP25L PF01105.19 KOG99080.1 - 2.2e-35 122.0 0.1 2.8e-35 121.7 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TMEM237 PF15383.1 KOG99080.1 - 0.014 14.4 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 237 ThiC PF01964.13 KOG99080.1 - 0.061 11.8 0.1 0.083 11.3 0.0 1.1 1 0 0 1 1 1 0 ThiC family GP41 PF00517.12 KOG99080.1 - 0.073 12.6 0.3 0.089 12.3 0.2 1.1 1 0 0 1 1 1 0 Retroviral envelope protein Ribosomal_S30AE PF02482.14 KOG99080.1 - 0.11 12.9 0.8 0.31 11.4 0.5 1.8 1 1 1 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein Pet127 PF08634.5 KOG99081.1 - 5.6e-112 373.3 11.7 3.6e-111 370.7 8.1 2.1 1 1 0 1 1 1 1 Mitochondrial protein Pet127 Arrestin_C PF02752.17 KOG99082.1 - 5.8e-23 81.5 0.0 5.8e-23 81.5 0.0 3.8 3 1 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 KOG99082.1 - 2.6e-13 50.0 0.1 1.3e-11 44.5 0.1 3.0 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.2 KOG99082.1 - 5.2e-05 22.8 0.1 0.00016 21.2 0.0 1.8 2 0 0 2 2 2 1 Arrestin_N terminal like RRM_1 PF00076.17 KOG99083.1 - 3.2e-40 135.5 9.5 6e-16 57.8 0.2 4.3 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG99083.1 - 8.3e-31 105.7 0.4 6.4e-12 45.2 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG99083.1 - 1.7e-18 66.2 1.4 1.3e-05 24.9 0.0 4.1 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 KOG99083.1 - 0.0013 18.4 0.2 1.8 8.3 0.0 3.8 3 1 0 3 3 3 1 Limkain b1 PCI PF01399.22 KOG99083.1 - 0.0054 17.0 0.0 0.26 11.6 0.0 3.2 3 1 0 3 3 3 1 PCI domain Mer2 PF09074.5 KOG99083.1 - 0.036 13.9 7.7 0.093 12.6 5.3 1.6 1 0 0 1 1 1 0 Mer2 Nup35_RRM_2 PF14605.1 KOG99083.1 - 0.12 12.2 0.0 2.2 8.1 0.0 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DUF500 PF04366.7 KOG99084.1 - 1.2e-43 147.5 1.2 1.4e-43 147.3 0.1 1.7 2 0 0 2 2 2 1 Family of unknown function (DUF500) SH3_1 PF00018.23 KOG99084.1 - 3.7e-18 64.6 0.1 7.9e-18 63.5 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOG99084.1 - 1e-13 50.6 0.0 1.8e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOG99084.1 - 3.1e-13 48.9 0.0 5.6e-13 48.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF1776 PF08643.5 KOG99085.1 - 2.6e-58 197.5 2.2 6e-58 196.3 1.5 1.5 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) MFS_1_like PF12832.2 KOG99085.1 - 0.00053 19.7 0.2 0.0013 18.5 0.1 1.6 1 0 0 1 1 1 1 MFS_1 like family DUF3514 PF12027.3 KOG99085.1 - 0.012 14.9 0.1 0.023 13.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3514) Lyase_1 PF00206.15 KOG99086.1 - 3.3e-96 322.1 0.0 4.6e-96 321.6 0.0 1.2 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.1 KOG99086.1 - 2.9e-26 91.3 0.1 9e-26 89.7 0.0 1.9 2 0 0 2 2 2 1 Argininosuccinate lyase C-terminal BBE PF08031.7 KOG99086.1 - 0.12 12.3 0.4 3.1 7.7 0.0 2.9 3 0 0 3 3 3 0 Berberine and berberine like tRNA-synt_2 PF00152.15 KOG99087.1 - 1.4e-74 250.9 0.0 2.3e-74 250.1 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KOG99087.1 - 6.2e-13 48.4 0.1 1.3e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Ins134_P3_kin PF05770.6 KOG99087.1 - 0.0089 15.0 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 1 Inositol 1, 3, 4-trisphosphate 5/6-kinase XhlA PF10779.4 KOG99087.1 - 0.36 10.7 3.8 0.67 9.9 2.6 1.4 1 0 0 1 1 1 0 Haemolysin XhlA PWWP PF00855.12 KOG99087.1 - 1.1 9.4 3.6 17 5.7 2.5 2.3 1 1 0 1 1 1 0 PWWP domain ProRS-C_1 PF09180.6 KOG99088.1 - 2.4e-25 88.2 0.8 5.5e-25 87.0 0.5 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.20 KOG99088.1 - 2.7e-22 79.1 0.0 4.9e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KOG99088.1 - 7.5e-19 67.4 0.2 1.8e-18 66.2 0.1 1.7 1 0 0 1 1 1 1 Anticodon binding domain Chorion_2 PF03964.10 KOG99088.1 - 0.096 13.2 0.5 0.21 12.1 0.3 1.5 1 0 0 1 1 1 0 Chorion family 2 K_channel_TID PF07941.6 KOG99088.1 - 1.6 9.0 6.3 3.4 7.9 4.4 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Myosin_head PF00063.16 KOG99089.1 - 1.2e-261 869.7 11.8 1.2e-261 869.7 8.2 4.7 4 2 1 5 5 5 1 Myosin head (motor domain) Myosin_N PF02736.14 KOG99089.1 - 0.0046 16.5 0.5 0.012 15.3 0.0 1.9 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain AAA_16 PF13191.1 KOG99089.1 - 0.053 13.5 0.0 0.053 13.5 0.0 4.3 4 1 0 4 4 4 0 AAA ATPase domain Peptidase_M16_C PF05193.16 KOG99090.1 - 1.1e-46 158.8 0.1 6.2e-46 156.3 0.0 2.2 3 0 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 KOG99090.1 - 4e-46 156.4 0.0 1.8e-43 147.8 0.0 2.2 2 0 0 2 2 2 2 Insulinase (Peptidase family M16) GHMP_kinases_N PF00288.21 KOG99091.1 - 2e-12 46.9 0.0 4.5e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 KOG99091.1 - 0.00035 20.6 0.0 0.00081 19.5 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal ATP-synt_C PF00137.16 KOG99092.1 - 4e-28 97.1 29.2 1.4e-18 66.5 6.0 2.4 2 0 0 2 2 2 2 ATP synthase subunit C PC_rep PF01851.17 KOG99093.1 - 2.8e-25 87.0 12.5 3.9e-07 29.9 0.1 8.5 9 0 0 9 9 9 6 Proteasome/cyclosome repeat ScpA_ScpB PF02616.9 KOG99093.1 - 0.89 9.0 13.0 0.1 12.1 1.9 2.3 2 0 0 2 2 2 0 ScpA/B protein RP-C_C PF11800.3 KOG99093.1 - 4.6 6.8 8.6 16 5.1 0.9 3.0 3 0 0 3 3 3 0 Replication protein C C-terminal region DPPIV_N PF00930.16 KOG99094.1 - 1.6e-101 339.4 5.4 2.2e-101 338.9 3.7 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 KOG99094.1 - 4.9e-52 176.2 1.5 9.1e-52 175.3 1.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 KOG99094.1 - 1.4e-08 34.6 0.0 2.4e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOG99094.1 - 0.00029 20.7 0.0 0.0014 18.5 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 KOG99094.1 - 0.021 14.2 0.1 1.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase PhzC-PhzF PF02567.11 KOG99095.1 - 1.5e-74 250.7 0.0 1.7e-74 250.5 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.6 KOG99095.1 - 0.1 11.4 0.0 1.8 7.3 0.0 2.1 2 0 0 2 2 2 0 Proline racemase Pkinase PF00069.20 KOG99096.1 - 1.3e-67 227.6 0.5 2e-67 227.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99096.1 - 2.5e-31 108.6 0.0 5.8e-31 107.5 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase DUF1635 PF07795.6 KOG99096.1 - 0.018 14.4 5.5 0.037 13.3 3.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Spt20 PF12090.3 KOG99096.1 - 0.037 13.3 5.9 0.082 12.2 4.1 1.5 1 0 0 1 1 1 0 Spt20 family APH PF01636.18 KOG99096.1 - 0.053 13.2 1.0 0.1 12.3 0.1 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family PAT1 PF09770.4 KOG99096.1 - 0.32 9.1 19.2 0.43 8.7 13.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RCR PF12273.3 KOG99096.1 - 4.1 7.9 16.0 1.5 9.3 9.1 1.7 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red PIF1 PF05970.9 KOG99097.1 - 2.1e-52 178.2 4.8 9.3e-46 156.4 1.2 2.2 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 KOG99097.1 - 5.8e-18 65.1 0.0 1.5e-17 63.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOG99097.1 - 6.1e-07 29.6 0.4 3.5e-06 27.1 0.1 2.4 3 0 0 3 3 3 1 AAA domain Herpes_Helicase PF02689.9 KOG99097.1 - 6e-05 21.0 0.2 0.0053 14.5 0.0 2.2 2 0 0 2 2 2 2 Helicase AAA PF00004.24 KOG99097.1 - 0.00028 21.0 0.1 0.00072 19.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 KOG99097.1 - 0.00041 20.0 0.2 0.00087 19.0 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain T2SE PF00437.15 KOG99097.1 - 0.0005 19.0 0.2 0.0009 18.2 0.2 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein PhoH PF02562.11 KOG99097.1 - 0.0033 16.6 0.1 0.0098 15.1 0.1 1.8 1 0 0 1 1 1 1 PhoH-like protein FtsK_SpoIIIE PF01580.13 KOG99097.1 - 0.005 16.3 0.1 0.016 14.6 0.0 1.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family Helicase_RecD PF05127.9 KOG99097.1 - 0.005 16.4 0.3 0.016 14.8 0.2 1.9 1 1 0 1 1 1 1 Helicase Viral_helicase1 PF01443.13 KOG99097.1 - 0.0069 15.9 0.1 0.32 10.4 0.0 2.9 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.4 KOG99097.1 - 0.011 14.7 0.1 0.028 13.3 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) UvrD_C_2 PF13538.1 KOG99097.1 - 0.018 15.1 0.0 0.32 11.1 0.0 2.7 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain Mg_chelatase PF01078.16 KOG99097.1 - 0.024 13.7 0.2 0.061 12.4 0.1 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KOG99097.1 - 0.026 14.2 0.3 0.11 12.1 0.2 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOG99097.1 - 0.031 14.2 0.1 0.086 12.8 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.22 KOG99097.1 - 0.042 14.1 0.8 0.13 12.5 0.3 1.9 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.17 KOG99097.1 - 0.087 12.9 0.8 1.1 9.5 0.2 2.8 2 1 0 2 2 2 0 RNA helicase Parvo_NS1 PF01057.12 KOG99097.1 - 0.094 11.5 0.0 0.18 10.6 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 MatE PF01554.13 KOG99098.1 - 4e-65 218.3 25.9 1.4e-35 122.3 6.3 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 KOG99098.1 - 6.6e-06 25.9 1.1 6.6e-06 25.9 0.8 3.9 4 1 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain AA_kinase PF00696.23 KOG99099.1 - 6.8e-37 127.2 0.1 1.2e-36 126.4 0.1 1.4 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.15 KOG99099.1 - 3.7e-15 55.4 0.0 7.3e-15 54.4 0.0 1.5 1 0 0 1 1 1 1 PUA domain PIH1 PF08190.7 KOG99100.1 - 1.4e-22 80.5 0.1 2.7e-22 79.6 0.1 1.4 1 1 0 1 1 1 1 pre-RNA processing PIH1/Nop17 Sec23_trunk PF04811.10 KOG99101.1 - 6.8e-18 64.9 0.1 1.5e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 KOG99101.1 - 0.00053 19.3 1.1 0.0025 17.2 0.0 2.6 3 0 0 3 3 3 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.10 KOG99101.1 - 0.018 14.6 3.8 0.059 12.9 2.6 1.9 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Brr6_like_C_C PF10104.4 KOG99102.1 - 2.9e-47 159.5 4.6 5.1e-47 158.7 3.2 1.4 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Dynactin PF12455.3 KOG99102.1 - 0.023 13.6 0.5 0.023 13.6 0.3 1.5 2 0 0 2 2 2 0 Dynein associated protein Herpes_glycop PF01528.11 KOG99102.1 - 0.084 11.5 0.3 0.14 10.7 0.2 1.2 1 0 0 1 1 1 0 Herpesvirus glycoprotein M Aldedh PF00171.17 KOG99103.1 - 7.9e-99 331.0 0.0 9.4e-99 330.8 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF3383 PF11863.3 KOG99103.1 - 0.027 13.1 0.5 0.068 11.8 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3383) RRF PF01765.14 KOG99104.1 - 1.1e-36 125.7 3.1 1.1e-36 125.7 2.2 1.5 1 1 1 2 2 2 1 Ribosome recycling factor DUF2884 PF11101.3 KOG99104.1 - 0.022 14.1 2.2 0.096 12.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) DUF2115 PF09888.4 KOG99104.1 - 1.1 9.3 5.3 0.91 9.6 0.7 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) Pox_polyA_pol_N PF12630.2 KOG99104.1 - 2.5 8.2 7.0 0.28 11.3 1.4 2.0 2 2 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain Aldedh PF00171.17 KOG99105.1 - 2e-125 418.7 0.0 2.4e-125 418.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF3953 PF13129.1 KOG99105.1 - 0.029 13.9 0.4 0.054 13.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3953) zf-HIT PF04438.11 KOG99106.1 - 5.7e-11 41.8 7.7 9.7e-11 41.1 5.4 1.4 1 0 0 1 1 1 1 HIT zinc finger PolC_DP2 PF03833.8 KOG99106.1 - 1.4 6.5 5.5 0.58 7.7 1.7 1.7 2 0 0 2 2 2 0 DNA polymerase II large subunit DP2 Med20 PF08612.6 KOG99107.1 - 6.9e-28 97.3 0.0 7.6e-28 97.1 0.0 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex FAD_binding_1 PF00667.15 KOG99108.1 - 2e-68 230.1 0.0 2.9e-68 229.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 KOG99108.1 - 2.9e-29 101.9 1.1 4.9e-29 101.1 0.8 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 KOG99108.1 - 1.4e-22 80.2 0.0 3.6e-22 78.9 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.2 KOG99108.1 - 0.012 15.6 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain Spore_IV_A PF09547.5 KOG99108.1 - 0.066 11.8 0.2 0.12 11.0 0.1 1.3 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) HAD_2 PF13419.1 KOG99109.1 - 1.5e-11 44.7 0.0 2.7e-11 44.0 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOG99109.1 - 1.1e-05 25.9 0.0 5.5e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOG99109.1 - 6e-05 22.6 0.1 0.0001 21.9 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.2 KOG99109.1 - 0.008 16.3 0.0 0.01 15.9 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Inositol_P PF00459.20 KOG99111.1 - 4.1e-71 239.4 0.0 4.5e-71 239.3 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family DUF1953 PF09196.5 KOG99111.1 - 0.054 13.2 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1953) Peptidase_M1 PF01433.15 KOG99112.1 - 1.2e-145 485.5 2.4 1.7e-145 484.9 1.6 1.3 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 KOG99112.1 - 3.1e-85 286.2 2.0 8.3e-85 284.8 0.7 2.0 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 KOG99112.1 - 8.4e-21 74.3 0.2 1.9e-20 73.2 0.1 1.6 1 0 0 1 1 1 1 Peptidase MA superfamily MFS_1 PF07690.11 KOG99113.1 - 2.2e-40 138.4 25.6 2.2e-40 138.4 17.8 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOG99113.1 - 2.4e-08 33.0 29.6 4.2e-08 32.1 20.5 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter Fijivirus_P9-2 PF06837.6 KOG99113.1 - 7.7 5.5 8.4 1.2 8.2 0.4 2.5 2 0 0 2 2 2 0 Fijivirus P9-2 protein FSH1 PF03959.8 KOG99114.1 - 5.2e-63 212.3 0.0 5.8e-63 212.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.11 KOG99114.1 - 0.00053 19.4 0.0 0.31 10.4 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 KOG99114.1 - 0.0031 17.2 0.0 0.0034 17.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.6 KOG99114.1 - 0.011 15.4 0.3 0.27 10.9 0.0 2.2 1 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.2 KOG99114.1 - 0.15 11.9 0.0 3.7 7.3 0.0 2.1 1 1 1 2 2 2 0 Alpha/beta hydrolase family Nramp PF01566.13 KOG99115.1 - 1.8e-93 313.1 14.6 2.5e-93 312.7 10.1 1.2 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein COX5A PF02284.11 KOG99116.1 - 8.9e-52 173.6 1.1 1.2e-51 173.2 0.7 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Nterm_IS4 PF13006.2 KOG99116.1 - 0.084 12.9 0.1 0.49 10.4 0.0 2.0 2 0 0 2 2 2 0 Insertion element 4 transposase N-terminal Ribosomal_L1 PF00687.16 KOG99117.1 - 1.2e-38 132.6 9.3 2.8e-38 131.4 6.5 1.6 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family PBP_sp32 PF07222.7 KOG99117.1 - 0.079 12.1 5.5 0.17 11.0 3.8 1.5 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Yeast_MT PF11403.3 KOG99118.1 - 1.6e-22 79.3 35.0 1.6e-22 79.3 24.3 1.5 2 0 0 2 2 2 1 Yeast metallothionein Zn_clus PF00172.13 KOG99119.1 - 5.1e-08 32.6 8.8 9.2e-08 31.8 6.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mucin PF01456.12 KOG99119.1 - 0.19 11.5 4.3 0.36 10.5 3.0 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Pro_isomerase PF00160.16 KOG99120.1 - 6.3e-45 153.1 0.9 7.4e-45 152.9 0.6 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD FTP PF07504.8 KOG99120.1 - 0.038 13.4 0.9 0.23 10.9 0.1 2.4 2 0 0 2 2 2 0 Fungalysin/Thermolysin Propeptide Motif Med6 PF04934.9 KOG99121.1 - 2.2e-54 182.8 0.8 2.9e-54 182.4 0.5 1.1 1 0 0 1 1 1 1 MED6 mediator sub complex component IGR PF09597.5 KOG99122.1 - 1.8e-26 91.7 0.5 2.8e-26 91.1 0.3 1.3 1 0 0 1 1 1 1 IGR protein motif Laminin_G_2 PF02210.19 KOG99123.1 - 0.0027 17.7 0.0 0.0049 16.9 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain PBD PF00786.23 KOG99124.1 - 0.001 19.4 0.8 0.0038 17.6 0.6 2.2 1 1 0 1 1 1 1 P21-Rho-binding domain RNase_P_p30 PF01876.11 KOG99125.1 - 2.2e-46 156.8 0.0 3.4e-46 156.1 0.0 1.3 1 0 0 1 1 1 1 RNase P subunit p30 ApbA PF02558.11 KOG99126.1 - 6.3e-35 119.8 0.0 8.9e-35 119.3 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.6 KOG99126.1 - 3e-24 85.3 0.0 5e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal NAD_Gly3P_dh_N PF01210.18 KOG99126.1 - 0.00023 20.9 0.0 0.0022 17.7 0.0 2.2 2 1 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus BBS2_C PF14782.1 KOG99126.1 - 0.06 11.9 0.8 0.087 11.3 0.6 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal HSP70 PF00012.15 KOG99127.1 - 5.2e-77 259.1 1.2 9.4e-76 254.9 0.2 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 KOG99127.1 - 6.6e-10 38.0 0.0 9.7e-10 37.5 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein PilM_2 PF11104.3 KOG99127.1 - 0.054 12.3 0.0 0.088 11.6 0.0 1.4 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; DEAD PF00270.24 KOG99128.1 - 2.8e-47 160.3 0.0 5.3e-47 159.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG99128.1 - 1.2e-26 92.3 0.0 1.2e-25 89.1 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOG99128.1 - 2.7e-06 27.3 2.4 2.1e-05 24.4 0.0 3.0 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 KOG99128.1 - 0.0092 15.7 0.0 0.1 12.3 0.0 2.6 3 0 0 3 3 3 1 Part of AAA domain Neur_chan_memb PF02932.11 KOG99128.1 - 0.1 12.4 0.1 0.17 11.7 0.1 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Brix PF04427.13 KOG99129.1 - 1.8e-61 207.1 3.8 2.6e-61 206.6 2.7 1.3 1 0 0 1 1 1 1 Brix domain DUF1223 PF06764.6 KOG99129.1 - 0.45 10.3 5.4 1 9.1 3.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) DUF2514 PF10721.4 KOG99129.1 - 8.3 6.0 16.6 0.06 13.0 4.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) Spore_coat_CotO PF14153.1 KOG99129.1 - 10 5.5 22.5 0.57 9.5 2.2 2.6 2 0 0 2 2 2 0 Spore coat protein CotO MaoC_dehydrat_N PF13452.1 KOG99130.1 - 0.014 15.2 0.0 5.1 6.8 0.0 2.4 2 0 0 2 2 2 0 N-terminal half of MaoC dehydratase MaoC_dehydratas PF01575.14 KOG99130.1 - 0.091 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 MaoC like domain DS PF01916.12 KOG99131.1 - 3.4e-150 499.1 0.1 4.1e-150 498.9 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase ECR1_N PF14382.1 KOG99132.1 - 2.4e-13 49.1 0.0 5.8e-13 47.8 0.0 1.7 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region MotA_activ PF09114.5 KOG99132.1 - 0.0089 15.7 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Transcription factor MotA, activation domain EXOSC1 PF10447.4 KOG99132.1 - 0.013 15.3 0.0 0.34 10.9 0.0 2.8 2 1 0 2 2 2 0 Exosome component EXOSC1/CSL4 Dicistro_VP4 PF11492.3 KOG99132.1 - 0.025 14.5 0.0 0.057 13.4 0.0 1.5 1 0 0 1 1 1 0 Cricket paralysis virus, VP4 Met_10 PF02475.11 KOG99133.1 - 6.7e-79 264.1 0.0 1.1e-78 263.3 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.11 KOG99133.1 - 0.0015 17.5 0.1 0.003 16.5 0.0 1.5 2 0 0 2 2 2 1 N2,N2-dimethylguanosine tRNA methyltransferase MethyltransfD12 PF02086.10 KOG99133.1 - 0.0028 17.1 0.0 0.0045 16.4 0.0 1.3 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase PrmA PF06325.8 KOG99133.1 - 0.035 13.2 0.0 0.059 12.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 KOG99133.1 - 0.05 14.1 0.0 0.11 13.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF4438 PF14505.1 KOG99133.1 - 0.051 12.3 0.0 0.08 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4438) Methyltransf_26 PF13659.1 KOG99133.1 - 0.065 13.2 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Cyclin_N PF00134.18 KOG99134.1 - 3.9e-09 36.1 0.0 6.3e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 KOG99134.1 - 2.2e-08 34.6 0.0 2.8e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Cyclin Prenyltrans PF00432.16 KOG99135.1 - 7.6e-27 92.5 2.2 1.4e-08 34.1 0.0 4.0 4 0 0 4 4 4 3 Prenyltransferase and squalene oxidase repeat Prenyltrans_1 PF13243.1 KOG99135.1 - 5.8e-21 74.5 0.0 1.4e-11 44.3 0.0 4.7 3 2 2 5 5 5 3 Prenyltransferase-like Prenyltrans_2 PF13249.1 KOG99135.1 - 9.8e-19 67.8 0.0 8.2e-13 48.7 0.0 4.3 3 1 1 4 4 4 3 Prenyltransferase-like Pec_lyase PF09492.5 KOG99135.1 - 3.5e-05 23.1 0.0 0.049 12.8 0.0 2.6 1 1 1 2 2 2 2 Pectic acid lyase A2M_comp PF07678.9 KOG99135.1 - 0.088 12.0 0.0 0.3 10.2 0.0 1.9 1 1 0 1 1 1 0 A-macroglobulin complement component Nop10p PF04135.7 KOG99136.1 - 7.1e-22 76.8 0.2 8.8e-22 76.5 0.1 1.2 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family Oxysterol_BP PF01237.13 KOG99137.1 - 1.3e-102 342.9 1.6 2.8e-102 341.8 1.1 1.5 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.1 KOG99137.1 - 2.5e-33 114.0 4.3 1.7e-32 111.3 0.4 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.24 KOG99137.1 - 2.6e-05 24.3 0.4 2.6e-05 24.3 0.3 2.7 2 0 0 2 2 2 1 PH domain PH_11 PF15413.1 KOG99137.1 - 0.62 10.3 11.0 0.53 10.5 3.6 3.4 2 1 0 2 2 2 0 Pleckstrin homology domain CN_hydrolase PF00795.17 KOG99138.1 - 2.7e-26 92.0 0.0 4.1e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.12 KOG99138.1 - 7.5e-23 80.6 0.0 2.1e-22 79.2 0.0 1.7 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.16 KOG99138.1 - 0.0027 17.2 0.0 0.005 16.3 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase Abhydrolase_1 PF00561.15 KOG99139.1 - 1.6e-19 70.4 0.0 2.6e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOG99139.1 - 3.1e-19 69.7 0.0 4.2e-19 69.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOG99139.1 - 8.3e-09 35.3 0.0 1.6e-08 34.4 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 KOG99139.1 - 0.00044 20.0 0.0 0.0016 18.2 0.0 1.9 2 0 0 2 2 2 1 Putative lysophospholipase Lipase_3 PF01764.20 KOG99139.1 - 0.0041 16.7 0.1 0.011 15.2 0.0 1.6 1 1 0 1 1 1 1 Lipase (class 3) VirJ PF06057.6 KOG99139.1 - 0.0045 16.8 0.0 0.014 15.1 0.0 1.8 2 0 0 2 2 2 1 Bacterial virulence protein (VirJ) DUF2974 PF11187.3 KOG99139.1 - 0.013 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Thioesterase PF00975.15 KOG99139.1 - 0.013 15.6 0.2 0.14 12.3 0.2 2.2 1 1 0 1 1 1 0 Thioesterase domain PGAP1 PF07819.8 KOG99139.1 - 0.021 14.4 0.0 0.031 13.8 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein PAF-AH_p_II PF03403.8 KOG99139.1 - 0.041 12.1 0.0 2.9 6.0 0.0 2.2 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II DUF2305 PF10230.4 KOG99139.1 - 0.046 13.1 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) DUF676 PF05057.9 KOG99139.1 - 0.059 12.6 0.0 0.16 11.2 0.0 1.7 2 0 0 2 2 2 0 Putative serine esterase (DUF676) AAA_35 PF14516.1 KOG99139.1 - 0.074 11.6 0.0 0.13 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Abhydrolase_2 PF02230.11 KOG99139.1 - 0.22 10.9 1.3 8 5.8 0.5 2.7 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase DUF1314 PF07013.6 KOG99140.1 - 0.0046 16.3 4.5 0.2 11.0 0.1 3.3 3 0 0 3 3 3 3 Protein of unknown function (DUF1314) SpoIIE PF07228.7 KOG99141.1 - 1.7e-40 138.7 0.0 3.7e-40 137.7 0.0 1.5 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.16 KOG99141.1 - 2.2e-08 33.8 0.4 6.3e-05 22.4 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 KOG99141.1 - 2.3e-06 27.1 0.0 4.9e-06 26.0 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C MIF4G PF02854.14 KOG99142.1 - 3.1e-64 216.2 32.1 3.2e-40 137.7 3.1 3.9 3 1 0 3 3 3 2 MIF4G domain Upf2 PF04050.9 KOG99142.1 - 6e-16 58.6 53.4 1.3e-13 51.0 37.0 2.6 1 1 0 1 1 1 1 Up-frameshift suppressor 2 CENP-T PF15511.1 KOG99142.1 - 0.047 12.9 26.1 0.077 12.2 18.1 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Nop14 PF04147.7 KOG99142.1 - 3.4 5.4 49.8 0.35 8.7 29.9 2.5 2 0 0 2 2 2 0 Nop14-like family ABA_GPCR PF12430.3 KOG99143.1 - 1.5e-65 219.9 4.8 1.5e-65 219.9 3.3 3.0 2 1 0 3 3 3 1 Abscisic acid G-protein coupled receptor DUF3735 PF12537.3 KOG99143.1 - 1.7e-17 63.2 0.0 4.9e-17 61.7 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3735) Sec20 PF03908.8 KOG99143.1 - 6.6 6.5 7.4 5.5 6.7 0.1 3.2 3 0 0 3 3 3 0 Sec20 Pkinase PF00069.20 KOG99144.1 - 8.2e-46 156.2 0.0 1.3e-45 155.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.7 KOG99144.1 - 4.6e-41 139.6 1.7 5.8e-41 139.3 0.1 2.1 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.12 KOG99144.1 - 4.1e-24 85.0 0.0 2.6e-23 82.4 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.16 KOG99144.1 - 1.1e-05 24.7 0.0 0.41 10.2 0.0 3.6 3 0 0 3 3 3 2 PQQ enzyme repeat Kdo PF06293.9 KOG99144.1 - 0.00022 20.3 0.0 0.00041 19.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ_2 PF13360.1 KOG99144.1 - 0.065 12.6 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 PQQ-like domain APH PF01636.18 KOG99144.1 - 0.092 12.4 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Swi5 PF07061.6 KOG99145.1 - 6.1e-22 77.2 3.5 7.3e-22 76.9 2.5 1.1 1 0 0 1 1 1 1 Swi5 DUF2951 PF11166.3 KOG99145.1 - 0.00071 19.3 2.9 0.00084 19.1 1.3 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF2951) eIF3_N PF09440.5 KOG99145.1 - 0.11 12.6 2.5 0.75 9.9 1.3 1.8 1 1 1 2 2 2 0 eIF3 subunit 6 N terminal domain Hep_59 PF07052.6 KOG99145.1 - 0.12 12.7 2.4 0.13 12.6 1.7 1.1 1 0 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 HAUS6_N PF14661.1 KOG99145.1 - 0.15 11.3 2.0 0.18 11.1 1.4 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Myb_DNA-bind_4 PF13837.1 KOG99145.1 - 0.17 12.0 1.2 0.29 11.3 0.8 1.5 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF342 PF03961.8 KOG99145.1 - 0.39 9.0 6.2 0.39 9.0 4.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF848 PF05852.6 KOG99145.1 - 0.6 9.9 3.4 0.71 9.7 2.4 1.1 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) IncA PF04156.9 KOG99145.1 - 0.71 9.4 7.0 0.8 9.2 4.8 1.1 1 0 0 1 1 1 0 IncA protein DivIVA PF05103.8 KOG99145.1 - 1.3 9.0 6.6 3.9 7.5 4.6 1.8 1 1 0 1 1 1 0 DivIVA protein TcdA_TcdB PF12919.2 KOG99145.1 - 2.4 6.5 6.3 1.8 6.9 3.4 1.5 1 1 1 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain Sugarporin_N PF11471.3 KOG99145.1 - 6.5 6.4 7.6 6.9 6.3 0.9 2.4 2 1 0 2 2 2 0 Maltoporin periplasmic N-terminal extension GRAM PF02893.15 KOG99146.1 - 1.3e-19 69.4 0.0 3.3e-19 68.1 0.0 1.8 1 0 0 1 1 1 1 GRAM domain Sas10_Utp3 PF04000.10 KOG99147.1 - 9.3e-09 35.3 4.0 9.3e-09 35.3 2.8 1.9 2 1 0 2 2 2 1 Sas10/Utp3/C1D family DUF904 PF06005.7 KOG99147.1 - 0.25 11.6 3.4 1.2 9.4 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Pkinase PF00069.20 KOG99148.1 - 9.8e-47 159.2 2.0 4.6e-43 147.2 0.4 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99148.1 - 6.6e-21 74.5 0.2 3.4e-20 72.2 0.1 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG99148.1 - 0.00011 21.2 0.0 0.00018 20.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like TF_Otx PF03529.8 KOG99148.1 - 0.03 14.5 5.8 0.02 15.0 2.1 2.2 2 0 0 2 2 2 0 Otx1 transcription factor Kdo PF06293.9 KOG99148.1 - 0.085 11.9 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2731 PF10806.3 KOG99149.1 - 4.4e-43 146.4 0.0 1e-42 145.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2731) STE PF02200.11 KOG99150.1 - 6.1e-60 200.1 3.3 9.7e-60 199.5 2.3 1.3 1 0 0 1 1 1 1 STE like transcription factor Ipi1_N PF12333.3 KOG99151.1 - 3.2e-26 91.2 1.4 4.2e-26 90.8 0.0 1.9 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation RRM_1 PF00076.17 KOG99152.1 - 8.5e-42 140.6 0.0 1.1e-16 60.1 0.0 4.2 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG99152.1 - 2.6e-24 84.9 0.0 2.6e-09 36.9 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG99152.1 - 2.9e-18 65.4 0.0 6.3e-08 32.3 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KOG99152.1 - 0.012 15.3 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 KOG99152.1 - 0.019 14.7 0.0 0.069 13.0 0.0 2.0 2 0 0 2 2 2 0 RNA binding motif SBDS PF01172.13 KOG99153.1 - 4.5e-16 58.4 0.3 5.1e-16 58.2 0.2 1.0 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Brix PF04427.13 KOG99154.1 - 3.3e-39 134.5 2.8 4.8e-39 133.9 2.0 1.2 1 0 0 1 1 1 1 Brix domain Gar1 PF04410.9 KOG99155.1 - 7.7e-43 145.6 0.0 7.7e-43 145.6 0.0 1.6 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region ING PF12998.2 KOG99156.1 - 3e-21 75.6 3.9 3e-21 75.6 2.7 1.7 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 KOG99156.1 - 6.2e-10 38.6 8.3 6.2e-10 38.6 5.8 1.7 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.1 KOG99156.1 - 0.051 13.7 1.8 0.068 13.3 0.4 1.9 2 0 0 2 2 2 0 PHD-like zinc-binding domain tRNA-synt_1d PF00750.14 KOG99157.1 - 6.8e-123 409.9 6.0 8.8e-123 409.6 4.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 KOG99157.1 - 6.7e-26 90.5 0.1 6.7e-25 87.3 0.0 2.3 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 KOG99157.1 - 8.9e-05 22.9 0.0 0.00023 21.6 0.0 1.8 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain Sugar_tr PF00083.19 KOG99158.1 - 9.8e-175 581.4 36.0 1.1e-174 581.2 25.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG99158.1 - 1.2e-28 99.8 45.1 3e-25 88.6 17.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2178 PF09946.4 KOG99158.1 - 0.081 12.6 4.5 7.5 6.3 1.5 3.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2178) Sugar_tr PF00083.19 KOG99159.1 - 7.7e-174 578.4 35.8 8.8e-174 578.3 24.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG99159.1 - 1.7e-30 105.9 30.4 3.3e-29 101.7 15.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 KOG99160.1 - 1.1e-169 564.8 36.4 1.2e-169 564.6 25.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG99160.1 - 1.9e-35 122.2 40.0 5.8e-33 114.0 16.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pal1 PF08316.6 KOG99161.1 - 2.5e-58 196.5 3.1 2.5e-58 196.5 2.1 2.6 3 1 0 3 3 3 1 Pal1 cell morphology protein Sec23_trunk PF04811.10 KOG99162.1 - 2.4e-66 223.5 0.1 5.5e-66 222.4 0.0 1.6 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 KOG99162.1 - 1.4e-21 75.8 0.8 3.6e-21 74.5 0.1 2.1 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 KOG99162.1 - 3.7e-14 53.0 0.0 7.9e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 KOG99162.1 - 2.6e-13 49.3 3.1 4.9e-13 48.4 2.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 KOG99162.1 - 7.9e-10 38.2 0.1 3.7e-09 36.1 0.0 2.2 3 0 0 3 3 3 1 Gelsolin repeat FAT PF02259.18 KOG99163.1 - 3.6e-70 236.7 8.5 7.2e-70 235.7 5.9 1.6 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.22 KOG99163.1 - 1.9e-53 181.3 1.5 1.9e-53 181.3 1.1 2.9 3 0 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 KOG99163.1 - 3.2e-07 29.6 0.0 8.5e-07 28.2 0.0 1.8 1 0 0 1 1 1 1 FATC domain TPR_11 PF13414.1 KOG99163.1 - 0.011 15.3 2.8 0.035 13.7 0.2 2.9 3 0 0 3 3 3 0 TPR repeat PGP_phosphatase PF09419.5 KOG99164.1 - 6.9e-72 240.2 0.0 7.9e-72 240.0 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.1 KOG99164.1 - 5.6e-05 22.7 0.0 9e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 KOG99164.1 - 0.1 13.0 0.0 0.23 11.8 0.0 1.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase ATP-synt_S1 PF05827.7 KOG99165.1 - 3.5e-52 177.4 0.0 4.3e-52 177.1 0.0 1.1 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Pkinase PF00069.20 KOG99166.1 - 3.8e-70 236.0 0.0 6.2e-70 235.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99166.1 - 6.1e-50 169.6 0.0 9.6e-50 169.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG99166.1 - 7.7e-06 25.0 0.1 3.6e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 KOG99166.1 - 0.14 11.8 0.0 0.33 10.6 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Aldo_ket_red PF00248.16 KOG99168.1 - 2.8e-47 160.9 0.0 3.6e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family PX PF00787.19 KOG99169.1 - 3.6e-19 68.6 0.2 4.8e-19 68.2 0.1 1.2 1 0 0 1 1 1 1 PX domain Pyr_redox_2 PF07992.9 KOG99170.1 - 8.2e-29 100.9 0.1 1e-28 100.6 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOG99170.1 - 4.4e-18 65.4 0.2 7.8e-15 55.0 0.1 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOG99170.1 - 6e-11 42.7 0.0 6.3e-08 32.9 0.0 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 KOG99170.1 - 5e-05 22.3 0.7 0.54 9.0 0.1 3.9 3 1 1 4 4 4 1 Glucose inhibited division protein A NAD_binding_7 PF13241.1 KOG99170.1 - 7.4e-05 22.9 0.1 0.033 14.4 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_8 PF13450.1 KOG99170.1 - 0.00026 20.9 0.0 0.022 14.7 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 KOG99170.1 - 0.0003 19.9 0.1 0.005 15.9 0.0 2.3 2 0 0 2 2 2 1 Thi4 family Shikimate_DH PF01488.15 KOG99170.1 - 0.0029 17.6 0.1 2.9 7.9 0.0 2.4 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase DAO PF01266.19 KOG99170.1 - 0.0032 16.4 0.0 0.81 8.5 0.0 2.9 2 1 1 3 3 3 1 FAD dependent oxidoreductase K_oxygenase PF13434.1 KOG99170.1 - 0.0071 15.2 0.0 0.59 8.9 0.0 2.8 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.9 KOG99170.1 - 0.028 12.8 0.4 1.1 7.5 0.1 2.7 2 1 1 3 3 3 0 HI0933-like protein FAD_binding_2 PF00890.19 KOG99170.1 - 0.042 12.6 0.8 0.65 8.7 0.2 2.7 3 1 1 4 4 4 0 FAD binding domain NAD_Gly3P_dh_N PF01210.18 KOG99170.1 - 0.08 12.6 0.1 7 6.3 0.1 2.4 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.14 KOG99170.1 - 0.085 11.8 0.1 8.5 5.3 0.1 2.2 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.1 KOG99170.1 - 0.11 12.2 0.0 8 6.2 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding Septin PF00735.13 KOG99171.1 - 5.1e-119 396.4 0.0 7.4e-119 395.9 0.0 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 KOG99171.1 - 1.4e-06 28.2 0.0 2.6e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 KOG99171.1 - 4.7e-06 25.8 0.0 1.2e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 KOG99171.1 - 0.00025 20.5 0.4 0.0074 15.7 0.0 2.5 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 KOG99171.1 - 0.00073 19.6 0.2 0.011 15.8 0.1 2.5 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.1 KOG99171.1 - 0.0019 17.8 0.0 0.0037 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 KOG99171.1 - 0.0057 16.1 0.0 0.014 14.8 0.0 1.6 1 0 0 1 1 1 1 FtsK/SpoIIIE family Miro PF08477.8 KOG99171.1 - 0.0074 16.7 0.0 0.037 14.5 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein RNA_helicase PF00910.17 KOG99171.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AIG1 PF04548.11 KOG99171.1 - 0.015 14.3 0.0 0.039 13.0 0.0 1.7 2 0 0 2 2 2 0 AIG1 family AAA_16 PF13191.1 KOG99171.1 - 0.018 15.0 0.2 0.054 13.4 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.22 KOG99171.1 - 0.018 15.3 0.0 0.058 13.6 0.0 1.8 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.7 KOG99171.1 - 0.023 14.3 0.0 0.058 13.0 0.0 1.6 2 0 0 2 2 1 0 NACHT domain Dynamin_N PF00350.18 KOG99171.1 - 0.028 14.2 3.8 9.1 6.0 0.0 3.2 2 1 1 3 3 3 0 Dynamin family AAA_33 PF13671.1 KOG99171.1 - 0.03 14.2 0.1 0.083 12.7 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_10 PF12846.2 KOG99171.1 - 0.036 13.5 0.0 0.061 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain Sigma54_activat PF00158.21 KOG99171.1 - 0.041 13.3 0.0 0.074 12.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Pox_A32 PF04665.7 KOG99171.1 - 0.049 12.9 0.1 0.086 12.1 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein Gtr1_RagA PF04670.7 KOG99171.1 - 0.099 11.7 0.0 0.41 9.7 0.0 2.0 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 KOG99171.1 - 0.13 11.7 0.9 0.64 9.5 0.2 2.3 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF3970 PF13113.1 KOG99171.1 - 3 7.5 5.4 26 4.5 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3970) VHS PF00790.14 KOG99172.1 - 2.3e-49 166.6 0.2 8.8e-49 164.7 0.0 2.0 2 0 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.15 KOG99172.1 - 1.3e-23 83.5 0.2 1.3e-23 83.5 0.2 2.1 2 0 0 2 2 2 1 Adaptin C-terminal domain GAT PF03127.9 KOG99172.1 - 3.1e-13 49.5 5.0 9.4e-13 48.0 3.5 1.8 1 0 0 1 1 1 1 GAT domain EMP24_GP25L PF01105.19 KOG99174.1 - 2.2e-49 167.6 0.4 2.6e-49 167.4 0.3 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4140 PF13600.1 KOG99174.1 - 0.053 13.9 0.0 0.15 12.5 0.0 1.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) NTR2 PF15458.1 KOG99174.1 - 0.059 12.6 0.8 0.079 12.1 0.5 1.2 1 0 0 1 1 1 0 Nineteen complex-related protein 2 Synaptobrevin PF00957.16 KOG99174.1 - 3.3 7.3 6.1 0.15 11.7 0.5 1.5 2 0 0 2 2 2 0 Synaptobrevin ThiF PF00899.16 KOG99175.1 - 6.4e-44 149.0 0.0 1.7e-43 147.6 0.0 1.7 2 0 0 2 2 2 1 ThiF family MoeZ_MoeB PF05237.8 KOG99175.1 - 6.1e-27 93.0 0.6 1.1e-26 92.2 0.4 1.4 1 0 0 1 1 1 1 MoeZ/MoeB domain Rhodanese PF00581.15 KOG99175.1 - 1.7e-16 60.5 0.0 3.9e-16 59.3 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Shikimate_DH PF01488.15 KOG99175.1 - 0.00011 22.2 0.0 0.00033 20.7 0.0 1.8 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 KOG99175.1 - 0.029 14.6 0.0 0.098 12.9 0.0 1.9 2 0 0 2 2 2 0 Putative NAD(P)-binding CDKN3 PF05706.7 KOG99175.1 - 0.039 13.3 0.0 0.092 12.1 0.0 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) RNA_pol_Rpb5_N PF03871.9 KOG99175.1 - 0.081 13.3 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb5, N-terminal domain Cys_Met_Meta_PP PF01053.15 KOG99176.1 - 9e-62 208.5 0.0 2.7e-61 206.9 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 KOG99176.1 - 0.00059 18.6 0.0 0.00091 18.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V SelA PF03841.8 KOG99176.1 - 0.1 11.2 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 L-seryl-tRNA selenium transferase Peptidase_M18 PF02127.10 KOG99177.1 - 2.3e-183 609.6 0.0 2.6e-183 609.4 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 KOG99177.1 - 4.9e-08 32.0 0.0 2.3e-05 23.3 0.0 2.4 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase SH3_9 PF14604.1 KOG99178.1 - 1.3e-27 95.1 0.3 7.1e-14 51.1 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.18 KOG99178.1 - 5.3e-25 87.4 1.8 1.5e-24 85.9 0.1 2.6 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.23 KOG99178.1 - 9.3e-25 85.7 0.4 9e-12 44.2 0.0 2.7 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.12 KOG99178.1 - 2.3e-14 52.5 0.0 2.2e-06 27.0 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain DAHP_synth_2 PF01474.11 KOG99178.1 - 0.027 12.8 3.9 0.23 9.7 0.1 2.2 2 0 0 2 2 2 0 Class-II DAHP synthetase family GvpH PF05455.6 KOG99178.1 - 0.03 13.9 0.1 0.03 13.9 0.1 1.7 2 0 0 2 2 2 0 GvpH FHA PF00498.21 KOG99179.1 - 1.4e-15 57.1 0.3 2.9e-15 56.1 0.2 1.6 1 0 0 1 1 1 1 FHA domain zf-RING_2 PF13639.1 KOG99179.1 - 1.2e-05 24.9 9.5 4.6e-05 23.1 7.1 1.6 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 KOG99179.1 - 1.8e-05 24.7 4.5 3.5e-05 23.8 3.1 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 KOG99179.1 - 0.0036 17.1 4.2 0.0071 16.1 2.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 KOG99179.1 - 0.0086 15.7 10.8 0.015 14.9 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOG99179.1 - 0.016 14.9 8.6 0.027 14.2 5.9 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Sec_GG PF07549.9 KOG99179.1 - 0.045 13.0 0.4 0.11 11.8 0.3 1.6 1 0 0 1 1 1 0 SecD/SecF GG Motif zf-HC5HC2H PF13771.1 KOG99179.1 - 0.075 13.1 4.0 0.15 12.2 2.7 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain NESP55 PF06390.7 KOG99179.1 - 0.086 12.2 2.2 0.22 10.8 1.5 1.6 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) zf-C3HC4_2 PF13923.1 KOG99179.1 - 0.12 12.4 12.3 0.22 11.5 8.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) C2-set PF05790.10 KOG99179.1 - 0.17 11.8 1.4 2.1 8.4 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin C2-set domain PHD PF00628.24 KOG99179.1 - 1.7 8.4 6.5 3.3 7.4 4.5 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.6 KOG99179.1 - 3.8 7.5 7.5 8.2 6.5 5.2 1.6 1 0 0 1 1 1 0 RING-like domain CHCH PF06747.8 KOG99180.1 - 4e-07 29.7 7.3 7e-07 29.0 5.0 1.4 1 0 0 1 1 1 1 CHCH domain DUF1903 PF08991.5 KOG99180.1 - 1.7e-05 24.8 4.2 2.4e-05 24.3 2.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1903) Pet191_N PF10203.4 KOG99180.1 - 0.058 13.4 2.8 0.085 12.9 1.9 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Me-amine-dh_L PF02975.9 KOG99180.1 - 0.085 12.8 0.8 0.19 11.7 0.5 1.6 1 1 0 1 1 1 0 Methylamine dehydrogenase, L chain UPF0203 PF05254.7 KOG99180.1 - 0.26 11.1 6.0 0.41 10.5 1.8 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) TPR_11 PF13414.1 KOG99181.1 - 2.5e-40 135.9 14.2 3.5e-17 61.8 0.0 6.8 3 2 3 7 7 7 6 TPR repeat TPR_2 PF07719.12 KOG99181.1 - 5.4e-31 103.9 15.2 2.8e-05 23.6 0.0 10.6 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_1 PF00515.23 KOG99181.1 - 5.8e-31 104.8 20.1 1.1e-06 28.0 0.3 10.3 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOG99181.1 - 5e-22 78.0 0.0 2.1e-05 25.0 0.0 6.5 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_17 PF13431.1 KOG99181.1 - 1.4e-20 71.6 9.8 0.00053 19.9 0.0 8.4 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOG99181.1 - 1.8e-18 66.6 16.0 2.6e-06 27.6 0.0 7.3 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOG99181.1 - 3.4e-18 64.4 0.6 0.076 13.6 0.0 9.7 6 4 5 11 11 11 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOG99181.1 - 5.4e-17 60.2 15.6 0.00083 18.9 0.1 10.0 8 1 2 10 10 10 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOG99181.1 - 1e-15 57.4 10.8 0.00025 20.9 0.0 7.0 5 1 4 9 9 9 6 Tetratricopeptide repeat Apc3 PF12895.2 KOG99181.1 - 9.2e-12 44.9 4.4 0.021 14.9 0.7 5.0 4 1 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 KOG99181.1 - 3.7e-11 42.7 0.0 0.00087 19.0 0.0 5.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOG99181.1 - 1.4e-07 30.7 8.1 0.38 10.6 0.0 7.7 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_3 PF07720.7 KOG99181.1 - 0.00047 19.8 16.0 0.013 15.3 0.3 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOG99181.1 - 0.0023 18.2 13.4 14 6.3 0.0 7.9 8 0 0 8 8 8 0 Tetratricopeptide repeat Peptidase_C37 PF05416.7 KOG99181.1 - 0.021 13.1 1.5 0.033 12.5 1.1 1.2 1 0 0 1 1 1 0 Southampton virus-type processing peptidase Protocadherin PF08374.6 KOG99181.1 - 0.063 12.9 1.7 0.12 12.0 1.2 1.3 1 0 0 1 1 1 0 Protocadherin TPR_10 PF13374.1 KOG99181.1 - 0.086 12.7 0.1 23 5.0 0.0 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat PPR PF01535.15 KOG99181.1 - 0.3 11.1 1.2 24 5.2 0.0 3.7 3 0 0 3 3 3 0 PPR repeat ORC6 PF05460.8 KOG99182.1 - 6.3e-102 341.2 3.3 7.4e-102 341.0 2.3 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Integrase_Zn PF02022.14 KOG99182.1 - 0.084 12.3 0.9 0.3 10.5 0.0 2.3 3 0 0 3 3 3 0 Integrase Zinc binding domain CDC45 PF02724.9 KOG99182.1 - 5.3 4.9 11.8 8.4 4.2 8.2 1.2 1 0 0 1 1 1 0 CDC45-like protein N-SET PF11764.3 KOG99183.1 - 4.7e-44 150.2 5.7 4.7e-44 150.2 4.0 3.6 4 0 0 4 4 4 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.23 KOG99183.1 - 1.1e-23 84.3 0.2 1.1e-23 84.3 0.1 3.7 5 2 0 5 5 5 1 SET domain SET_assoc PF11767.3 KOG99183.1 - 1.1e-21 75.9 2.3 1.1e-21 75.8 0.2 2.2 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated MutS_V PF00488.16 KOG99184.1 - 3.1e-77 259.1 0.0 4.8e-77 258.5 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 KOG99184.1 - 3.9e-34 118.2 4.7 8.3e-34 117.1 3.3 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 KOG99184.1 - 1.9e-28 98.7 0.0 4.4e-28 97.5 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.12 KOG99184.1 - 1.8e-11 44.2 0.6 6.4e-11 42.4 0.0 2.2 2 0 0 2 2 2 1 MutS domain II DUF2097 PF09870.4 KOG99184.1 - 0.25 11.4 2.6 2.8 8.0 1.7 2.8 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2097) AD PF09793.4 KOG99185.1 - 2.2e-26 91.4 0.1 3.5e-26 90.8 0.1 1.3 1 0 0 1 1 1 1 Anticodon-binding domain DUF3074 PF11274.3 KOG99185.1 - 0.044 13.4 0.1 0.065 12.8 0.1 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) Peroxin-22 PF12827.2 KOG99185.1 - 0.072 12.8 0.8 0.097 12.3 0.4 1.4 1 1 0 1 1 1 0 Peroxisomal biogenesis protein family LSM14 PF12701.2 KOG99185.1 - 0.13 12.0 0.7 0.38 10.6 0.2 2.0 2 1 0 2 2 2 0 Scd6-like Sm domain DUF59 PF01883.14 KOG99186.1 - 9.7e-06 25.4 0.0 1.7e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF59 NDT80_PhoG PF05224.7 KOG99187.1 - 1.7e-69 233.5 0.1 4.6e-69 232.1 0.0 1.7 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family PIR PF00399.14 KOG99188.1 - 8.3e-08 31.3 4.7 8.3e-08 31.3 3.3 2.0 2 0 0 2 2 2 1 Yeast PIR protein repeat DUF1034 PF06280.7 KOG99188.1 - 0.26 11.7 3.3 1 9.8 0.3 2.7 2 1 0 2 2 2 0 Fn3-like domain (DUF1034) UPRTase PF14681.1 KOG99190.1 - 2.9e-76 255.2 0.0 3.4e-76 255.0 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 KOG99190.1 - 0.0049 16.5 0.0 0.0083 15.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Flu_C_NS1 PF03506.8 KOG99190.1 - 0.071 12.8 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) Actin PF00022.14 KOG99191.1 - 1.6e-113 379.1 0.0 1.9e-113 378.8 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 KOG99191.1 - 0.18 10.4 0.1 3.3 6.2 0.0 2.4 3 0 0 3 3 3 0 MreB/Mbl protein PH_9 PF15410.1 KOG99192.1 - 0.048 13.8 3.9 0.72 10.0 2.7 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain Nop14 PF04147.7 KOG99192.1 - 9.9 3.9 27.7 28 2.4 19.2 1.8 1 1 0 1 1 1 0 Nop14-like family Peptidase_M14 PF00246.19 KOG99193.1 - 8.1e-72 242.1 0.1 9.7e-72 241.8 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Endosulfine PF04667.12 KOG99194.1 - 9.9e-34 115.1 0.1 1.3e-33 114.7 0.1 1.2 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Act-Frag_cataly PF09192.5 KOG99194.1 - 0.068 12.1 0.0 0.08 11.9 0.0 1.1 1 0 0 1 1 1 0 Actin-fragmin kinase, catalytic INSIG PF07281.7 KOG99195.1 - 6.4e-13 48.4 4.2 1.4e-12 47.3 2.6 1.7 1 1 1 2 2 2 1 Insulin-induced protein (INSIG) Thia_YuaJ PF09515.5 KOG99195.1 - 0.082 12.6 5.3 0.6 9.8 2.1 2.2 2 0 0 2 2 2 0 Thiamine transporter protein (Thia_YuaJ) WLM PF08325.5 KOG99196.1 - 1.4e-54 184.7 0.0 1.8e-54 184.4 0.0 1.1 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.12 KOG99196.1 - 0.03 14.1 0.1 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF45 Mesothelin PF06060.7 KOG99196.1 - 0.083 10.9 0.0 0.11 10.5 0.0 1.1 1 0 0 1 1 1 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Pkinase PF00069.20 KOG99197.1 - 1.5e-33 116.1 0.0 1.5e-33 116.1 0.0 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99197.1 - 1.2e-12 47.5 0.0 1.2e-12 47.5 0.0 2.6 3 0 0 3 3 3 1 Protein tyrosine kinase TGFb_propeptide PF00688.13 KOG99198.1 - 0.017 14.4 5.8 0.02 14.1 4.0 1.1 1 0 0 1 1 1 0 TGF-beta propeptide DUF1395 PF07160.7 KOG99198.1 - 0.058 12.8 3.5 0.069 12.6 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1395) DUF3736 PF12540.3 KOG99198.1 - 0.061 13.5 12.0 0.092 12.9 8.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3736) Erythro_esteras PF05139.9 KOG99198.1 - 0.087 11.9 4.1 0.099 11.8 2.9 1.0 1 0 0 1 1 1 0 Erythromycin esterase DUF4613 PF15390.1 KOG99198.1 - 1.3 7.1 4.1 1.5 6.9 2.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DUF2489 PF10675.4 KOG99198.1 - 1.3 8.6 8.7 0.27 10.9 3.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) DUF106 PF01956.11 KOG99198.1 - 1.4 8.3 3.9 1.7 8.1 2.7 1.1 1 0 0 1 1 1 0 Integral membrane protein DUF106 Carbpep_Y_N PF05388.6 KOG99199.1 - 0.11 12.7 0.1 0.15 12.2 0.0 1.4 1 1 0 1 1 1 0 Carboxypeptidase Y pro-peptide Asparaginase PF00710.15 KOG99200.1 - 1.3e-23 83.3 4.3 3.3e-23 82.0 3.0 1.6 1 1 0 1 1 1 1 Asparaginase Far-17a_AIG1 PF04750.9 KOG99201.1 - 2.2e-14 53.1 8.4 2.6e-14 52.8 5.8 1.1 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein HDA2-3 PF11496.3 KOG99201.1 - 0.15 10.8 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 Chs3p PF12271.3 KOG99202.1 - 9.2e-99 330.1 22.7 2.6e-98 328.6 15.8 1.6 1 1 0 1 1 1 1 Chitin synthase III catalytic subunit DUF3980 PF13140.1 KOG99202.1 - 0.086 13.1 6.2 0.33 11.2 4.3 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3980) DNA_RNApol_7kD PF03604.8 KOG99204.1 - 1.9e-16 59.2 1.8 2.5e-16 58.8 1.3 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.2 KOG99204.1 - 0.0031 17.2 0.4 0.0042 16.8 0.3 1.2 1 0 0 1 1 1 1 Double zinc ribbon TFIIS_C PF01096.13 KOG99204.1 - 0.0055 16.3 0.6 2.9 7.6 0.1 2.3 2 0 0 2 2 2 2 Transcription factor S-II (TFIIS) HypA PF01155.14 KOG99204.1 - 0.0061 16.2 0.2 0.0061 16.2 0.1 1.1 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family Prok-RING_1 PF14446.1 KOG99204.1 - 0.007 16.0 0.7 0.0092 15.6 0.5 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 GFA PF04828.9 KOG99204.1 - 0.028 14.3 0.5 2.2 8.2 0.0 2.0 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme NCD3G PF07562.9 KOG99204.1 - 0.03 14.0 0.3 0.038 13.7 0.2 1.2 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR FYDLN_acid PF09538.5 KOG99204.1 - 0.046 14.3 0.3 0.055 14.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) C1_1 PF00130.17 KOG99204.1 - 0.047 13.4 0.5 0.067 12.9 0.4 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF951 PF06107.6 KOG99204.1 - 0.061 12.8 1.3 1.5 8.3 0.2 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF951) A2L_zn_ribbon PF08792.5 KOG99204.1 - 0.063 12.7 0.9 0.94 9.0 0.0 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain FYVE_2 PF02318.11 KOG99204.1 - 0.066 13.1 0.3 0.072 12.9 0.2 1.1 1 0 0 1 1 1 0 FYVE-type zinc finger DUF2318 PF10080.4 KOG99204.1 - 0.071 12.8 0.1 0.081 12.6 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) DUF2197 PF09963.4 KOG99204.1 - 0.072 13.0 2.2 7.2 6.6 0.2 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) DUF4428 PF14471.1 KOG99204.1 - 0.086 12.5 1.7 1.4 8.7 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4428) Zn_ribbon_recom PF13408.1 KOG99204.1 - 0.21 11.8 3.1 3.5 7.9 0.5 2.1 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain Ribosomal_L40e PF01020.12 KOG99204.1 - 0.32 10.6 2.7 0.42 10.2 1.9 1.2 1 0 0 1 1 1 0 Ribosomal L40e family Zn-ribbon_8 PF09723.5 KOG99204.1 - 0.35 10.8 3.4 1.2 9.2 2.3 1.8 1 1 0 1 1 1 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.2 KOG99204.1 - 0.43 10.4 3.2 2.4 8.0 2.6 1.8 1 1 1 2 2 2 0 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.7 KOG99204.1 - 0.53 9.6 2.5 8.3 5.8 2.1 2.0 1 1 2 3 3 3 0 TFIIB zinc-binding dCMP_cyt_deam_1 PF00383.17 KOG99205.1 - 1e-25 89.2 2.6 1.5e-25 88.7 1.8 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region FLO_LFY PF01698.11 KOG99206.1 - 1.4 7.7 22.2 0.21 10.4 1.4 2.1 2 0 0 2 2 2 0 Floricaula / Leafy protein FAM60A PF15396.1 KOG99206.1 - 5.3 6.7 21.8 0.48 10.1 0.9 2.4 2 0 0 2 2 2 0 Protein Family FAM60A Ribosomal_L6 PF00347.18 KOG99207.1 - 2.6e-28 98.3 1.7 3.3e-15 56.3 0.2 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 NUMOD4 PF07463.6 KOG99207.1 - 0.044 13.6 0.0 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 NUMOD4 motif Ribosomal_S4 PF00163.14 KOG99208.1 - 9.1e-27 93.2 2.3 2.4e-26 91.9 1.8 1.5 2 0 0 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 KOG99208.1 - 5.4e-13 48.1 0.0 1.9e-12 46.3 0.0 1.9 2 0 0 2 2 2 1 S4 domain Baculo_gp41 PF04700.7 KOG99208.1 - 0.059 12.8 0.1 0.09 12.2 0.1 1.3 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region THDPS_N_2 PF14805.1 KOG99208.1 - 0.093 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal Herpes_LAMP2 PF06126.6 KOG99208.1 - 0.14 10.4 0.1 0.17 10.2 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus Latent membrane protein 2 SKG6 PF08693.5 KOG99209.1 - 2.2e-15 55.6 6.8 3.8e-15 54.9 4.7 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.1 KOG99209.1 - 5.3e-05 22.7 0.8 0.00014 21.4 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) TMEM154 PF15102.1 KOG99209.1 - 0.00011 21.9 0.1 0.00011 21.9 0.1 2.5 3 0 0 3 3 3 1 TMEM154 protein family DUF912 PF06024.7 KOG99209.1 - 0.0013 18.7 0.1 0.0013 18.7 0.1 3.5 4 0 0 4 4 4 1 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF2615 PF11027.3 KOG99209.1 - 0.033 14.1 0.0 0.11 12.4 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) Vma12 PF11712.3 KOG99209.1 - 0.045 13.4 0.2 0.93 9.1 0.0 2.9 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Adeno_E3_CR2 PF02439.10 KOG99209.1 - 0.051 13.1 2.7 0.085 12.4 1.9 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EII-Sor PF03609.9 KOG99209.1 - 0.092 12.0 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 PTS system sorbose-specific iic component 7tm_1 PF00001.16 KOG99209.1 - 0.1 11.7 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) EphA2_TM PF14575.1 KOG99209.1 - 0.11 12.9 0.0 0.11 12.9 0.0 3.4 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Pex24p PF06398.6 KOG99210.1 - 1.4e-73 247.8 2.1 1.7e-73 247.4 1.5 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin PRT_C PF08372.5 KOG99210.1 - 0.0041 16.6 0.1 0.0083 15.6 0.1 1.4 1 0 0 1 1 1 1 Plant phosphoribosyltransferase C-terminal Reticulon PF02453.12 KOG99210.1 - 0.034 13.7 2.2 1.9 8.0 0.3 2.3 2 0 0 2 2 2 0 Reticulon Spo12 PF05032.7 KOG99212.1 - 2e-17 62.4 1.5 2e-17 62.4 1.0 1.9 2 0 0 2 2 2 1 Spo12 family DUF2693 PF10902.3 KOG99212.1 - 0.053 13.4 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2693) SprA-related PF12118.3 KOG99212.1 - 3.1 7.0 9.2 3.5 6.8 6.4 1.1 1 0 0 1 1 1 0 SprA-related family Rad33 PF08730.5 KOG99213.1 - 0.024 14.1 0.8 0.98 8.8 0.0 2.4 1 1 2 3 3 3 0 Rad33 BRCT PF00533.21 KOG99214.1 - 2.4e-25 88.4 9.1 5.1e-09 36.1 0.1 5.9 5 0 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 KOG99214.1 - 4.1e-15 55.3 0.0 7.6e-11 41.7 0.0 3.0 2 0 0 2 2 2 2 twin BRCT domain PH PF00169.24 KOG99215.1 - 7.5e-08 32.5 3.5 3.5e-07 30.3 0.1 3.3 3 0 0 3 3 3 1 PH domain GYF PF02213.11 KOG99216.1 - 1.3e-09 37.5 3.9 3.7e-09 36.0 2.7 1.9 1 0 0 1 1 1 1 GYF domain DTHCT PF08070.6 KOG99216.1 - 0.23 12.1 5.4 0.62 10.7 3.7 1.7 1 0 0 1 1 1 0 DTHCT (NUC029) region PRCC PF10253.4 KOG99216.1 - 1.3 9.6 9.9 4 8.1 0.7 2.4 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting DUF2963 PF11178.3 KOG99217.1 - 0.1 12.0 1.7 0.54 9.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2963) Kelch_3 PF13415.1 KOG99218.1 - 1.9e-36 123.3 1.8 5.7e-08 32.7 0.0 6.0 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KOG99218.1 - 6.5e-34 115.3 4.8 3e-06 27.0 0.2 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KOG99218.1 - 3.2e-28 97.2 8.2 1.9e-06 27.5 0.1 6.6 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.1 KOG99218.1 - 1.1e-27 94.9 5.6 1.2e-06 28.4 0.0 6.3 4 2 2 6 6 6 5 Kelch motif Kelch_1 PF01344.20 KOG99218.1 - 1.1e-24 85.6 2.0 6.4e-07 28.8 0.0 5.7 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 KOG99218.1 - 5.5e-15 54.4 6.3 0.0023 17.6 0.0 6.7 6 1 0 6 6 6 5 Kelch motif ANTH PF07651.11 KOG99221.1 - 5.4e-70 235.2 1.2 5.4e-70 235.2 0.8 1.8 2 0 0 2 2 2 1 ANTH domain ENTH PF01417.15 KOG99221.1 - 3.3e-08 33.4 0.0 1.1e-07 31.7 0.0 1.9 1 0 0 1 1 1 1 ENTH domain MPC PF03650.8 KOG99222.1 - 2.6e-54 182.2 0.2 3e-54 182.0 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) MtN3_slv PF03083.11 KOG99222.1 - 0.0084 15.9 0.1 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange Glucosamine_iso PF01182.15 KOG99223.1 - 9.5e-53 178.8 0.0 1.1e-52 178.6 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Dna2 PF08696.6 KOG99224.1 - 1.9e-63 213.5 0.2 5.4e-63 212.0 0.1 1.9 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.1 KOG99224.1 - 5.5e-49 166.2 0.1 5.5e-49 166.2 0.1 1.9 2 0 0 2 2 1 1 AAA domain AAA_11 PF13086.1 KOG99224.1 - 3.1e-35 121.8 0.2 1.2e-19 70.8 0.0 3.5 3 1 1 4 4 4 2 AAA domain AAA_30 PF13604.1 KOG99224.1 - 1.5e-14 54.0 0.0 3.9e-14 52.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOG99224.1 - 2.3e-08 33.6 0.0 5.2e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain PDDEXK_1 PF12705.2 KOG99224.1 - 4.2e-08 32.8 0.0 9.4e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Viral_helicase1 PF01443.13 KOG99224.1 - 2.5e-05 23.9 0.1 0.19 11.2 0.2 3.9 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase PIF1 PF05970.9 KOG99224.1 - 7.7e-05 21.8 0.0 0.00023 20.2 0.0 1.7 1 1 0 1 1 1 1 PIF1-like helicase Helicase_RecD PF05127.9 KOG99224.1 - 0.00012 21.7 0.0 0.00037 20.1 0.0 1.9 1 0 0 1 1 1 1 Helicase MobB PF03205.9 KOG99224.1 - 0.00072 19.2 0.2 0.0034 17.0 0.1 2.1 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 KOG99224.1 - 0.00078 19.4 0.2 0.0053 16.7 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain CbiA PF01656.18 KOG99224.1 - 0.00081 18.8 0.4 0.0099 15.3 0.1 2.7 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54 PF00448.17 KOG99224.1 - 0.0014 18.1 0.0 0.0034 16.8 0.0 1.7 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Cas_Cas4 PF01930.12 KOG99224.1 - 0.022 14.7 5.5 0.022 14.6 0.0 3.0 3 0 0 3 3 2 0 Domain of unknown function DUF83 AAA_22 PF13401.1 KOG99224.1 - 0.042 13.9 0.3 0.44 10.6 0.0 2.9 2 1 0 2 2 1 0 AAA domain AAA_18 PF13238.1 KOG99224.1 - 0.045 14.0 3.0 0.056 13.7 0.0 2.7 2 1 0 2 2 2 0 AAA domain ArgK PF03308.11 KOG99224.1 - 0.087 11.5 0.3 0.22 10.2 0.0 1.7 2 0 0 2 2 2 0 ArgK protein UvrD_C_2 PF13538.1 KOG99224.1 - 0.12 12.5 0.0 0.59 10.3 0.0 2.3 2 0 0 2 2 1 0 UvrD-like helicase C-terminal domain AAA_25 PF13481.1 KOG99224.1 - 0.14 11.4 0.0 0.32 10.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain PROCN PF08083.6 KOG99226.1 - 8e-221 732.6 12.7 1.3e-220 731.9 8.8 1.4 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.3 KOG99226.1 - 3.1e-121 402.9 1.8 3.1e-121 402.9 1.3 2.1 2 0 0 2 2 2 1 PRP8 domain IV core U6-snRNA_bdg PF10596.4 KOG99226.1 - 1.1e-88 294.6 0.6 2.4e-88 293.5 0.4 1.6 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.6 KOG99226.1 - 5.6e-78 259.8 3.2 9.5e-78 259.0 1.6 1.9 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.4 KOG99226.1 - 1.4e-64 215.7 0.0 3.9e-64 214.3 0.0 1.8 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.6 KOG99226.1 - 6.4e-47 158.3 0.0 1.6e-46 157.0 0.0 1.8 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.4 KOG99226.1 - 2.6e-45 152.1 0.3 8.2e-45 150.6 0.2 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 APC8 PF04049.8 KOG99227.1 - 4.2e-36 123.8 0.1 1.1e-35 122.4 0.0 1.6 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.23 KOG99227.1 - 5.8e-26 88.9 14.6 0.00041 19.8 0.0 8.2 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.1 KOG99227.1 - 6.6e-23 80.1 16.5 2.1e-08 33.6 0.1 5.8 6 1 1 7 7 6 4 TPR repeat TPR_8 PF13181.1 KOG99227.1 - 6.5e-22 75.6 17.8 0.0046 16.6 0.0 8.6 8 1 1 9 9 8 5 Tetratricopeptide repeat TPR_2 PF07719.12 KOG99227.1 - 8.1e-21 72.2 13.4 0.031 14.1 0.1 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.1 KOG99227.1 - 1.5e-16 60.0 11.0 0.0016 18.3 0.1 5.7 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOG99227.1 - 1e-12 47.4 0.0 0.01 16.3 0.0 7.5 6 2 3 9 9 8 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOG99227.1 - 5.2e-11 41.8 8.0 0.002 18.1 0.0 7.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOG99227.1 - 8.6e-10 37.6 1.1 0.35 10.7 0.0 5.6 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOG99227.1 - 4.8e-09 36.6 1.7 0.017 15.8 0.0 6.7 7 1 1 8 8 7 1 Tetratricopeptide repeat Apc3 PF12895.2 KOG99227.1 - 1.2e-06 28.5 20.7 0.0023 18.0 2.2 6.2 4 2 3 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 KOG99227.1 - 4.5e-06 26.9 4.7 3.5 8.0 0.0 6.6 7 1 1 8 8 7 2 Tetratricopeptide repeat ChAPs PF09295.5 KOG99227.1 - 6.8e-06 25.1 0.0 4.6e-05 22.3 0.0 2.1 1 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) RPN7 PF10602.4 KOG99227.1 - 4.7e-05 22.8 4.1 0.00016 21.1 0.2 3.2 3 0 0 3 3 3 1 26S proteasome subunit RPN7 MIT PF04212.13 KOG99227.1 - 0.00013 21.7 0.3 0.063 13.1 0.0 3.4 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_15 PF13429.1 KOG99227.1 - 0.00065 18.8 2.3 0.36 9.8 0.1 3.7 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOG99227.1 - 0.0027 18.0 16.0 3.9 8.1 0.0 8.3 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOG99227.1 - 0.023 14.5 0.1 0.77 9.6 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOG99227.1 - 0.031 14.2 0.2 1.2 9.1 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Flp_N PF03930.9 KOG99227.1 - 0.26 11.0 2.6 0.85 9.4 0.1 2.5 2 0 0 2 2 2 0 Recombinase Flp protein N-terminus THP2 PF09432.5 KOG99228.1 - 1.7e-58 196.2 2.9 3.5e-58 195.1 2.0 1.5 1 0 0 1 1 1 1 Tho complex subunit THP2 Retrotrans_gag PF03732.12 KOG99228.1 - 0.025 14.6 1.9 0.1 12.6 0.1 2.6 2 1 1 3 3 3 0 Retrotransposon gag protein Phasin PF05597.6 KOG99228.1 - 0.041 13.6 0.5 3.4 7.4 0.0 3.2 3 0 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4570 PF15134.1 KOG99228.1 - 0.042 13.6 0.2 0.11 12.3 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) Snf7 PF03357.16 KOG99228.1 - 0.1 11.9 4.0 0.18 11.2 0.8 2.6 2 1 0 2 2 2 0 Snf7 DUF2310 PF10071.4 KOG99228.1 - 0.15 11.0 4.3 0.095 11.6 0.5 2.4 4 0 0 4 4 4 0 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) Mnd1 PF03962.10 KOG99228.1 - 0.23 11.1 0.1 0.23 11.1 0.1 2.3 2 1 1 3 3 3 0 Mnd1 family Syntaxin PF00804.20 KOG99228.1 - 0.47 10.6 3.9 0.63 10.2 0.2 2.7 2 2 0 2 2 2 0 Syntaxin DUF972 PF06156.8 KOG99228.1 - 4.2 7.7 9.0 4.2 7.7 0.7 3.2 2 2 0 3 3 3 0 Protein of unknown function (DUF972) GTP1_OBG PF01018.17 KOG99229.1 - 8.1e-31 106.7 4.4 5e-21 74.9 1.7 2.3 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.18 KOG99229.1 - 3.2e-21 75.4 0.0 5.2e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOG99229.1 - 1.5e-11 43.8 0.0 2.4e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.16 KOG99229.1 - 7.4e-09 35.0 0.2 1.9e-08 33.7 0.2 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KOG99229.1 - 0.00085 18.8 0.3 0.1 11.9 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Miro PF08477.8 KOG99229.1 - 0.0017 18.8 0.0 0.0045 17.4 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 KOG99229.1 - 0.031 13.4 0.0 0.074 12.2 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DEAD PF00270.24 KOG99230.1 - 1.2e-38 132.2 0.2 3.7e-37 127.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG99230.1 - 4.1e-27 93.8 0.1 1e-26 92.5 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOG99230.1 - 0.0041 16.9 0.2 0.016 15.0 0.0 2.3 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit NMD3 PF04981.8 KOG99231.1 - 3.4e-74 248.9 1.5 3.4e-74 248.9 1.0 1.6 2 0 0 2 2 2 1 NMD3 family DZR PF12773.2 KOG99231.1 - 2.3 8.1 8.4 13 5.7 4.1 2.8 2 1 1 3 3 3 0 Double zinc ribbon zinc_ribbon_6 PF14599.1 KOG99231.1 - 8.9 6.1 7.4 0.67 9.7 0.0 2.8 2 1 1 3 3 3 0 Zinc-ribbon ThiF PF00899.16 KOG99232.1 - 2.2e-30 105.2 0.0 7.4e-30 103.5 0.0 1.9 2 0 0 2 2 2 1 ThiF family Shikimate_DH PF01488.15 KOG99232.1 - 0.00057 19.9 0.0 0.0037 17.3 0.0 2.1 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase Spc97_Spc98 PF04130.8 KOG99233.1 - 5.3e-79 265.9 19.8 6.4e-79 265.7 13.7 1.0 1 0 0 1 1 1 1 Spc97 / Spc98 family Enolase_C PF00113.17 KOG99234.1 - 3.3e-151 502.2 0.0 4.5e-151 501.8 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 KOG99234.1 - 8.9e-55 184.2 0.4 1.7e-54 183.3 0.3 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.1 KOG99234.1 - 0.0017 18.2 0.1 0.0075 16.2 0.0 2.1 2 0 0 2 2 2 1 Enolase C-terminal domain-like MAAL_C PF07476.6 KOG99234.1 - 0.015 14.2 0.3 0.054 12.4 0.0 1.9 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus MR_MLE PF01188.16 KOG99234.1 - 0.041 14.4 0.0 0.18 12.3 0.0 2.2 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain Ctr PF04145.10 KOG99235.1 - 9.2e-34 116.5 9.2 8.3e-32 110.2 6.4 2.0 1 1 0 1 1 1 1 Ctr copper transporter family Competence PF03772.11 KOG99235.1 - 0.013 14.6 0.7 0.025 13.6 0.5 1.5 1 1 0 1 1 1 0 Competence protein LysE PF01810.13 KOG99235.1 - 0.031 13.5 3.2 0.047 12.9 2.2 1.2 1 0 0 1 1 1 0 LysE type translocator DUF2897 PF11446.3 KOG99235.1 - 0.15 11.8 0.2 0.37 10.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) Abi PF02517.11 KOG99235.1 - 0.83 9.8 5.7 1.3 9.2 0.8 2.2 2 0 0 2 2 2 0 CAAX protease self-immunity FMO-like PF00743.14 KOG99236.1 - 1e-39 136.1 0.9 1.1e-31 109.6 0.1 2.2 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 KOG99236.1 - 3.2e-17 63.2 0.0 2.7e-15 57.0 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KOG99236.1 - 2.8e-15 56.4 0.1 9.3e-12 44.9 0.0 2.9 2 2 1 3 3 3 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 KOG99236.1 - 2.9e-09 37.0 0.0 8.5e-08 32.3 0.0 2.3 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 KOG99236.1 - 3.5e-06 26.1 2.3 0.00026 20.0 0.0 2.9 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 KOG99236.1 - 5.9e-06 26.2 0.0 2.2e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOG99236.1 - 0.00048 19.1 0.0 0.23 10.3 0.0 3.1 2 1 0 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.12 KOG99236.1 - 0.0022 17.1 0.0 0.16 11.0 0.0 2.2 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.9 KOG99236.1 - 0.003 16.1 1.8 0.8 8.1 0.0 2.8 3 1 1 4 4 4 2 HI0933-like protein Pyr_redox PF00070.22 KOG99236.1 - 0.0031 17.8 0.3 22 5.5 0.1 3.4 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.18 KOG99236.1 - 0.01 15.5 0.1 8.1 6.1 0.0 3.0 3 0 0 3 3 3 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GIDA PF01134.17 KOG99236.1 - 0.035 12.9 0.6 0.82 8.4 0.0 2.5 3 0 0 3 3 3 0 Glucose inhibited division protein A Fungal_trans PF04082.13 KOG99237.1 - 6.7e-33 113.6 0.0 6.7e-33 113.6 0.0 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG99237.1 - 5.3e-08 32.6 11.2 9.7e-08 31.8 7.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1216 PF06746.6 KOG99237.1 - 0.46 10.2 4.0 0.27 11.0 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1216) Dickkopf_N PF04706.7 KOG99237.1 - 4.7 7.4 11.6 1.3 9.2 5.3 2.1 2 0 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region Oxidored_FMN PF00724.15 KOG99238.1 - 1e-135 452.1 0.0 1.2e-135 451.9 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Ribosomal_L30_N PF08079.7 KOG99238.1 - 0.058 13.4 1.2 0.14 12.2 0.9 1.6 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain Erv26 PF04148.8 KOG99239.1 - 1.9e-89 298.6 4.8 2.1e-89 298.4 3.4 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 DUF996 PF06195.8 KOG99239.1 - 0.011 15.7 2.1 0.024 14.6 1.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF996) Cytochrom_C_asm PF01578.15 KOG99239.1 - 0.34 10.4 5.9 0.074 12.5 0.9 2.1 1 1 1 2 2 2 0 Cytochrome C assembly protein RhoGAP PF00620.22 KOG99240.1 - 0.00047 19.7 2.3 0.00065 19.3 0.1 2.4 3 0 0 3 3 3 1 RhoGAP domain 6PGD PF00393.14 KOG99241.1 - 1.5e-133 444.4 0.0 1.9e-133 444.1 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 KOG99241.1 - 2e-52 177.2 0.0 3e-52 176.7 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 KOG99241.1 - 0.026 14.6 0.0 0.1 12.6 0.0 2.0 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 KOG99241.1 - 0.044 14.2 0.1 0.088 13.2 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 KOG99241.1 - 0.12 11.4 0.0 0.46 9.6 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Raptor_N PF14538.1 KOG99244.1 - 3.5e-65 218.5 0.0 3.5e-65 218.5 0.0 3.1 3 0 0 3 3 3 1 Raptor N-terminal CASPase like domain BBS2_Mid PF14783.1 KOG99244.1 - 2.8e-07 30.2 0.1 0.00026 20.7 0.0 3.0 2 0 0 2 2 2 2 Ciliary BBSome complex subunit 2, middle region HEAT PF02985.17 KOG99244.1 - 3.8e-07 29.6 1.1 0.0034 17.3 0.0 5.0 5 0 0 5 5 5 1 HEAT repeat WD40 PF00400.27 KOG99244.1 - 2.5e-05 23.9 3.2 2.7 8.0 0.0 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat HEAT_2 PF13646.1 KOG99244.1 - 0.00032 20.9 0.0 0.0049 17.1 0.0 2.7 3 0 0 3 3 3 1 HEAT repeats OmpH PF03938.9 KOG99244.1 - 0.0029 17.5 5.3 0.0029 17.5 3.6 3.0 3 0 0 3 3 3 1 Outer membrane protein (OmpH-like) Elong_Iki1 PF10483.4 KOG99245.1 - 1e-92 310.4 0.2 1.2e-92 310.3 0.1 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 Gpi16 PF04113.9 KOG99246.1 - 2.2e-175 583.8 0.0 3e-175 583.4 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Pept_tRNA_hydro PF01195.14 KOG99247.1 - 3.9e-43 147.0 0.0 4.4e-43 146.9 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase SQS_PSY PF00494.14 KOG99248.1 - 8.4e-40 136.7 0.0 1.1e-39 136.4 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Ctf8 PF09696.5 KOG99249.1 - 2.1e-29 101.7 0.1 3.3e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 Ctf8 DUF2296 PF10058.4 KOG99250.1 - 1.3e-14 53.6 0.4 2.4e-14 52.8 0.3 1.4 1 0 0 1 1 1 1 Predicted integral membrane metal-binding protein (DUF2296) FYDLN_acid PF09538.5 KOG99250.1 - 0.024 15.2 1.8 0.024 15.2 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) YjgP_YjgQ PF03739.9 KOG99250.1 - 0.053 12.2 0.0 0.083 11.6 0.0 1.3 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family DUF1469 PF07332.6 KOG99250.1 - 0.1 12.3 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) PRTase_2 PF15609.1 KOG99250.1 - 0.11 11.8 0.1 0.18 11.1 0.1 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase DUF2197 PF09963.4 KOG99250.1 - 0.15 12.0 2.3 0.17 11.8 0.2 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) Zn_Tnp_IS1595 PF12760.2 KOG99250.1 - 0.18 11.6 7.2 0.97 9.2 5.1 2.0 1 1 1 2 2 2 0 Transposase zinc-ribbon domain PhnA_Zn_Ribbon PF08274.7 KOG99250.1 - 1.2 8.9 7.4 36 4.2 5.2 2.5 1 1 1 2 2 2 0 PhnA Zinc-Ribbon NAC PF01849.13 KOG99251.1 - 9e-19 66.7 1.6 1.1e-18 66.4 0.2 1.8 2 0 0 2 2 2 1 NAC domain UBA PF00627.26 KOG99251.1 - 6.9e-06 25.7 0.1 1.9e-05 24.3 0.1 1.8 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.1 KOG99251.1 - 0.00041 19.8 0.1 0.0011 18.4 0.0 1.8 1 0 0 1 1 1 1 UBA-like domain TMF_DNA_bd PF12329.3 KOG99251.1 - 0.058 13.2 0.1 0.058 13.2 0.1 3.2 4 0 0 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF1079 PF06435.6 KOG99251.1 - 0.34 10.8 0.1 0.34 10.8 0.1 2.7 3 0 0 3 3 3 0 Repeat of unknown function (DUF1079) MDM31_MDM32 PF08118.6 KOG99252.1 - 7.2e-268 889.0 9.8 8.3e-268 888.8 6.8 1.0 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins Trypan_PARP PF05887.6 KOG99253.1 - 1.8 8.3 5.4 3.1 7.6 3.8 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PD40 PF07676.7 KOG99254.1 - 0.014 15.0 0.9 1.9 8.2 0.0 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Utp12 PF04003.7 KOG99254.1 - 0.019 14.8 0.4 0.038 13.8 0.3 1.5 1 0 0 1 1 1 0 Dip2/Utp12 Family RIX1 PF08167.7 KOG99255.1 - 3.6e-42 143.8 5.8 6.4e-42 143.0 2.7 2.3 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis Chalcone PF02431.10 KOG99256.1 - 1.2e-55 188.0 0.1 1.5e-55 187.6 0.1 1.1 1 0 0 1 1 1 1 Chalcone-flavanone isomerase Pribosyltran PF00156.22 KOG99256.1 - 0.094 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase domain Chalcone PF02431.10 KOG99257.1 - 2.9e-42 144.3 0.0 3.5e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 Chalcone-flavanone isomerase DUF2789 PF10982.3 KOG99258.1 - 0.0099 15.8 1.2 0.012 15.5 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2789) Nbl1_Borealin_N PF10444.4 KOG99258.1 - 0.26 10.7 2.1 0.32 10.3 1.4 1.2 1 0 0 1 1 1 0 Nbl1 / Borealin N terminal DUF2205 PF10224.4 KOG99258.1 - 0.8 9.3 6.8 0.66 9.5 1.2 2.0 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) VWA_2 PF13519.1 KOG99259.1 - 2.1e-07 31.1 0.0 3.2e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.9 KOG99259.1 - 2.1e-06 27.4 0.0 3.1e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like Aminotran_1_2 PF00155.16 KOG99259.1 - 0.035 13.0 0.0 2.5 6.9 0.0 2.1 2 0 0 2 2 2 0 Aminotransferase class I and II DUF2405 PF10293.4 KOG99259.1 - 0.12 12.0 1.8 0.47 10.1 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2405) DHHA2 PF02833.9 KOG99260.1 - 8.3e-29 100.3 0.4 1.5e-28 99.5 0.1 1.6 2 0 0 2 2 2 1 DHHA2 domain DHH PF01368.15 KOG99260.1 - 1.2e-07 31.4 0.5 4.7e-07 29.5 0.4 1.9 1 1 0 1 1 1 1 DHH family PMT PF02366.13 KOG99261.1 - 2.4e-69 233.4 12.5 2.4e-69 233.4 8.6 1.6 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 KOG99261.1 - 1.4e-16 60.5 0.7 2.5e-16 59.7 0.5 1.4 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.1 KOG99261.1 - 5e-07 29.7 9.8 5e-07 29.7 6.8 2.9 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Metallophos PF00149.23 KOG99262.1 - 1.1e-12 47.7 0.8 2e-12 46.9 0.6 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase MRI PF15325.1 KOG99262.1 - 0.0062 17.4 0.2 0.011 16.6 0.2 1.4 1 0 0 1 1 1 1 Modulator of retrovirus infection Ribosomal_S4e PF00900.15 KOG99263.1 - 3.5e-34 116.3 1.3 1.4e-32 111.1 0.4 2.3 2 0 0 2 2 2 1 Ribosomal family S4e KOW PF00467.24 KOG99263.1 - 7.4e-06 25.4 1.5 7.4e-06 25.4 1.0 3.6 4 0 0 4 4 4 1 KOW motif S4 PF01479.20 KOG99263.1 - 0.00028 20.2 0.0 0.00069 18.9 0.0 1.7 1 0 0 1 1 1 1 S4 domain Cache_1 PF02743.13 KOG99263.1 - 0.097 12.2 0.1 0.29 10.7 0.0 1.9 2 0 0 2 2 2 0 Cache domain Glyco_hydro_47 PF01532.15 KOG99264.1 - 2.1e-117 392.5 0.0 3e-117 392.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Pkinase PF00069.20 KOG99265.1 - 5.8e-69 232.1 0.0 1e-68 231.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99265.1 - 2.7e-30 105.3 0.0 3.9e-30 104.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 KOG99265.1 - 5.3e-11 42.8 2.0 5.3e-11 42.8 1.4 2.7 3 0 0 3 3 3 1 Protein kinase C terminal domain Kinase-like PF14531.1 KOG99265.1 - 7.7e-10 38.2 0.0 1.9e-09 36.8 0.0 1.6 2 0 0 2 2 2 1 Kinase-like C2 PF00168.25 KOG99265.1 - 3.2e-06 26.8 0.0 0.13 12.0 0.0 2.6 2 0 0 2 2 2 2 C2 domain YrbL-PhoP_reg PF10707.4 KOG99265.1 - 0.065 12.5 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 KOG99265.1 - 0.17 11.5 0.1 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family HSF_DNA-bind PF00447.12 KOG99266.1 - 1.4e-34 118.3 2.0 4e-34 116.9 1.4 1.8 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.19 KOG99266.1 - 2.7e-25 88.5 0.3 7.8e-25 87.0 0.2 1.8 2 0 0 2 2 2 1 Response regulator receiver domain Myosin_tail_1 PF01576.14 KOG99266.1 - 0.0046 14.7 0.4 0.0062 14.3 0.3 1.1 1 0 0 1 1 1 1 Myosin tail SET PF00856.23 KOG99267.1 - 1e-12 48.6 0.5 5.8e-12 46.2 0.4 2.4 1 1 0 1 1 1 1 SET domain Aminotran_4 PF01063.14 KOG99268.1 - 1.3e-29 103.3 0.0 1.6e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV Zn_clus PF00172.13 KOG99269.1 - 6.9e-08 32.2 10.4 1.4e-07 31.2 7.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF554 PF04474.7 KOG99269.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF554) Methyltransf_11 PF08241.7 KOG99270.1 - 4.2e-17 62.4 0.0 6.8e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOG99270.1 - 2.6e-14 53.0 0.0 4.2e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOG99270.1 - 1.3e-13 51.2 0.0 4.7e-13 49.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOG99270.1 - 1.3e-12 48.2 0.0 2e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOG99270.1 - 2.4e-11 43.9 0.0 7.5e-11 42.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOG99270.1 - 3.1e-10 40.0 0.0 4.9e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOG99270.1 - 1.4e-06 27.6 0.0 2.9e-06 26.5 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 KOG99270.1 - 6.9e-06 26.0 0.0 2.2e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOG99270.1 - 7.5e-05 21.9 0.0 0.00011 21.4 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.9 KOG99270.1 - 0.0038 16.6 0.0 0.006 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.1 KOG99270.1 - 0.024 14.3 0.0 0.04 13.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.6 KOG99270.1 - 0.059 12.0 0.0 0.11 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) UPF0020 PF01170.13 KOG99270.1 - 0.064 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Alkyl_sulf_dimr PF14863.1 KOG99271.1 - 3.6e-61 205.5 2.0 5.9e-61 204.8 1.4 1.4 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Alkyl_sulf_C PF14864.1 KOG99271.1 - 7.5e-32 109.9 0.6 1.3e-31 109.1 0.4 1.4 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Lactamase_B PF00753.22 KOG99271.1 - 2.5e-31 108.8 0.2 4.4e-31 108.0 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily SCP2 PF02036.12 KOG99271.1 - 7.3e-07 29.4 0.0 1.8e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 SCP-2 sterol transfer family Lactamase_B_2 PF12706.2 KOG99271.1 - 0.00026 20.5 0.0 0.00045 19.8 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 KOG99271.1 - 0.099 12.3 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain MFS_1 PF07690.11 KOG99272.1 - 1.2e-16 60.3 15.4 1.7e-16 59.9 10.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOG99273.1 - 1.5e-89 300.6 6.5 1.7e-89 300.5 4.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG99273.1 - 8.3e-20 70.7 8.8 1.1e-19 70.3 6.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 KOG99273.1 - 4e-05 22.0 2.4 5.6e-05 21.5 1.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ATG22 PF11700.3 KOG99273.1 - 0.0001 20.9 8.9 0.00017 20.2 6.2 1.3 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_2 PF13347.1 KOG99273.1 - 0.00068 18.1 2.1 0.00068 18.1 1.4 1.9 3 0 0 3 3 3 1 MFS/sugar transport protein MFS_3 PF05977.8 KOG99273.1 - 0.01 13.9 2.0 0.014 13.5 1.4 1.1 1 0 0 1 1 1 0 Transmembrane secretion effector Pox_A14 PF05767.7 KOG99273.1 - 0.044 13.7 2.0 0.17 11.8 0.0 2.3 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 DUF3816 PF12822.2 KOG99273.1 - 2.7 7.8 17.8 19 5.1 5.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3816) Grp1_Fun34_YaaH PF01184.14 KOG99274.1 - 1.1e-61 207.8 12.1 1.3e-61 207.6 8.4 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Asp PF00026.18 KOG99275.1 - 1.1e-59 202.2 6.8 1.1e-59 202.2 4.7 2.0 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOG99275.1 - 1.6e-10 41.2 0.8 1.6e-10 41.2 0.6 2.3 3 0 0 3 3 3 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 KOG99275.1 - 1.8e-08 34.7 0.5 0.025 15.0 0.0 3.6 3 0 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.1 KOG99275.1 - 0.0049 16.6 0.1 0.55 10.1 0.0 2.4 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Aldose_epim PF01263.15 KOG99276.1 - 3.2e-74 249.7 0.0 3.6e-74 249.5 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Pyr_redox_2 PF07992.9 KOG99277.1 - 9e-15 55.0 0.1 1.3e-14 54.6 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOG99277.1 - 9.2e-14 51.6 0.1 5.1e-10 39.6 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOG99277.1 - 0.00066 18.6 0.0 0.068 12.0 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 KOG99277.1 - 0.0018 18.0 0.0 0.38 10.5 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding K_oxygenase PF13434.1 KOG99277.1 - 0.021 13.7 0.0 7.8 5.3 0.0 2.9 1 1 2 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 KOG99277.1 - 0.049 13.6 0.2 0.64 10.0 0.0 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain ABC2_membrane PF01061.19 KOG99278.1 - 2.3e-65 219.7 66.6 1.5e-40 138.5 14.8 2.8 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.22 KOG99278.1 - 2.1e-39 134.9 0.0 4.8e-19 69.0 0.1 2.9 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.7 KOG99278.1 - 6.6e-39 131.7 8.0 1.4e-32 111.3 0.0 3.3 3 0 0 3 3 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.2 KOG99278.1 - 3.3e-13 49.4 51.7 8.5e-12 44.7 13.5 3.3 2 2 0 2 2 2 2 ABC-2 family transporter protein ABC_trans_N PF14510.1 KOG99278.1 - 1.7e-10 40.8 0.0 4.7e-10 39.4 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal DUF258 PF03193.11 KOG99278.1 - 9e-06 24.9 0.1 0.00063 18.9 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 KOG99278.1 - 1.9e-05 24.1 0.1 0.0017 17.7 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 KOG99278.1 - 0.00034 20.6 0.6 0.045 13.7 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.1 KOG99278.1 - 0.00047 20.2 0.0 0.077 12.9 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.1 KOG99278.1 - 0.001 18.5 0.4 0.042 13.3 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.1 KOG99278.1 - 0.0011 19.0 0.1 0.0096 16.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 KOG99278.1 - 0.0015 19.0 0.1 0.6 10.6 0.0 2.8 2 0 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 KOG99278.1 - 0.0028 17.6 0.0 0.11 12.3 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_15 PF13175.1 KOG99278.1 - 0.0036 16.3 0.3 0.022 13.8 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain cobW PF02492.14 KOG99278.1 - 0.0052 16.2 0.2 0.0052 16.2 0.2 1.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 KOG99278.1 - 0.0065 16.7 0.0 0.084 13.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.14 KOG99278.1 - 0.0092 15.2 0.0 2.3 7.4 0.0 3.2 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 KOG99278.1 - 0.021 15.6 0.0 0.071 13.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KOG99278.1 - 0.027 14.4 0.0 0.056 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Septin PF00735.13 KOG99278.1 - 0.054 12.4 0.0 0.12 11.3 0.0 1.5 1 0 0 1 1 1 0 Septin Zeta_toxin PF06414.7 KOG99278.1 - 0.061 12.4 0.2 1.6 7.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin UPF0079 PF02367.12 KOG99278.1 - 0.074 12.6 0.9 0.47 10.0 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 KOG99278.1 - 0.078 12.6 0.3 0.25 10.9 0.1 2.0 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.1 KOG99278.1 - 0.1 12.4 0.3 0.26 11.1 0.0 1.9 2 0 0 2 2 1 0 AAA domain Dynamin_N PF00350.18 KOG99278.1 - 0.11 12.3 0.1 0.11 12.3 0.0 2.0 3 0 0 3 3 1 0 Dynamin family AAA_10 PF12846.2 KOG99278.1 - 0.13 11.6 1.4 0.35 10.2 0.1 2.1 2 0 0 2 2 2 0 AAA-like domain AAA_23 PF13476.1 KOG99278.1 - 0.14 12.4 0.4 0.37 11.1 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_19 PF13245.1 KOG99278.1 - 0.23 11.2 2.6 9.1 6.1 0.5 2.7 2 0 0 2 2 2 0 Part of AAA domain FtsK_SpoIIIE PF01580.13 KOG99278.1 - 0.25 10.8 0.1 1.9 7.9 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family Sir1 PF11603.3 KOG99280.1 - 1.3e-08 35.0 3.3 2.5e-08 34.1 1.3 1.8 1 1 1 2 2 2 1 Regulatory protein Sir1 ADH_zinc_N PF00107.21 KOG99281.1 - 2.7e-15 56.0 0.0 4.3e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOG99281.1 - 0.00021 21.0 0.1 0.01 15.6 0.0 2.4 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 KOG99281.1 - 0.087 13.7 0.0 0.18 12.6 0.0 1.6 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Zip PF02535.17 KOG99282.1 - 1.5e-60 204.9 2.2 1.7e-60 204.7 1.5 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter DUF1469 PF07332.6 KOG99282.1 - 0.2 11.3 2.7 0.3 10.7 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) zf-C2H2 PF00096.21 KOG99283.1 - 1.2e-08 34.8 32.4 1.7e-05 24.8 0.5 5.9 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KOG99283.1 - 3.4e-08 33.3 24.1 0.00039 20.5 1.4 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOG99283.1 - 6.4e-07 29.2 26.0 0.013 15.8 0.7 5.6 5 0 0 5 5 5 3 C2H2-type zinc finger zf-met PF12874.2 KOG99283.1 - 3e-06 27.2 9.2 0.045 13.9 0.4 5.3 5 1 1 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KOG99283.1 - 0.00015 21.7 4.1 0.0034 17.4 0.1 4.3 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.7 KOG99283.1 - 0.16 12.1 14.1 5.9 7.0 0.0 4.3 3 1 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Hexokinase_2 PF03727.11 KOG99284.1 - 7.8e-99 329.7 0.0 1.1e-98 329.2 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KOG99284.1 - 1.6e-86 288.9 0.0 2.1e-86 288.4 0.0 1.2 1 0 0 1 1 1 1 Hexokinase FGGY_N PF00370.16 KOG99284.1 - 0.05 12.9 0.0 0.096 11.9 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Sec63 PF02889.11 KOG99285.1 - 8.3e-49 166.4 0.6 1.4e-48 165.7 0.4 1.3 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.24 KOG99285.1 - 3.6e-30 104.6 0.1 1.1e-28 99.8 0.0 2.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.10 KOG99285.1 - 7.1e-13 48.7 0.7 5.1e-12 45.9 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 KOG99285.1 - 6.6e-11 41.9 0.0 1.8e-10 40.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 KOG99285.1 - 0.00042 20.4 0.1 0.0038 17.3 0.0 2.6 1 1 0 1 1 1 1 AAA domain T2SE PF00437.15 KOG99285.1 - 0.033 13.0 0.0 0.078 11.8 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF1160 PF06648.6 KOG99285.1 - 0.054 13.2 0.5 0.86 9.4 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1160) AAA_19 PF13245.1 KOG99285.1 - 0.075 12.7 0.0 0.24 11.1 0.0 1.8 2 0 0 2 2 2 0 Part of AAA domain UvrD-helicase PF00580.16 KOG99285.1 - 0.28 10.4 0.0 0.28 10.4 0.0 3.3 3 1 0 3 3 3 0 UvrD/REP helicase N-terminal domain DUF2420 PF10336.4 KOG99286.1 - 5.7e-42 141.8 0.4 8.8e-42 141.3 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) PDEase_II PF02112.10 KOG99288.1 - 6.8e-108 360.5 0.1 8.2e-108 360.2 0.0 1.0 1 0 0 1 1 1 1 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.2 KOG99288.1 - 1.8e-06 27.6 0.2 2.4e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Brr6_like_C_C PF10104.4 KOG99289.1 - 1.3e-42 144.5 0.7 1.5e-42 144.3 0.5 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Baculo_11_kDa PF06143.6 KOG99289.1 - 0.012 14.9 0.3 0.012 14.9 0.2 1.9 2 0 0 2 2 2 0 Baculovirus 11 kDa family GP41 PF00517.12 KOG99289.1 - 0.082 12.4 0.4 0.7 9.4 0.1 2.0 2 0 0 2 2 2 0 Retroviral envelope protein MSC PF09402.5 KOG99289.1 - 0.43 9.2 2.7 0.23 10.1 0.0 1.8 2 1 0 2 2 2 0 Man1-Src1p-C-terminal domain RAI1 PF08652.6 KOG99290.1 - 5.4e-28 96.5 0.4 1e-27 95.6 0.3 1.5 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease tRNA-synt_1c PF00749.16 KOG99291.1 - 7.8e-119 395.9 0.1 1e-118 395.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 KOG99291.1 - 1.2e-39 135.7 2.0 2.9e-39 134.5 0.6 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_3 PF14497.1 KOG99291.1 - 0.00022 21.6 0.0 0.0007 20.0 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 KOG99291.1 - 0.0037 17.1 0.0 0.0095 15.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOG99291.1 - 0.0086 16.0 0.0 0.027 14.4 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF3352 PF11832.3 KOG99291.1 - 0.15 10.3 0.0 0.21 9.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3352) Plus-3 PF03126.13 KOG99292.1 - 2.5e-33 114.3 0.1 2.5e-33 114.3 0.1 2.7 3 0 0 3 3 3 1 Plus-3 domain A_deamin PF02137.13 KOG99293.1 - 3.4e-61 207.4 0.0 4e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain Ank PF00023.25 KOG99294.1 - 2.4e-12 46.0 0.1 0.00019 21.0 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.2 KOG99294.1 - 2.3e-11 43.8 0.0 2.3e-08 34.2 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOG99294.1 - 1.7e-09 37.8 0.4 0.00012 22.4 0.0 2.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOG99294.1 - 4e-09 36.4 0.0 0.00044 20.3 0.0 4.1 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOG99294.1 - 6e-08 32.1 0.0 0.0011 19.0 0.0 3.8 3 1 0 3 3 3 2 Ankyrin repeat IBN_N PF03810.14 KOG99295.1 - 2.4e-11 43.4 0.4 2.4e-11 43.4 0.3 3.2 3 0 0 3 3 3 1 Importin-beta N-terminal domain DUF3015 PF11220.3 KOG99295.1 - 0.2 11.2 1.2 0.54 9.8 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3015) APC10 PF03256.11 KOG99296.1 - 2.1e-64 216.6 0.0 2.9e-64 216.2 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.20 KOG99296.1 - 0.0067 16.2 0.0 0.012 15.4 0.0 1.5 1 1 0 1 1 1 1 F5/8 type C domain Cse1 PF08506.5 KOG99297.1 - 6.9e-173 574.3 11.9 1.3e-172 573.4 8.2 1.5 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.10 KOG99297.1 - 2.4e-106 355.6 13.4 2.4e-106 355.6 9.3 1.8 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.14 KOG99297.1 - 1.6e-19 69.5 0.1 9.6e-17 60.6 0.0 3.9 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.7 KOG99297.1 - 0.011 15.6 0.1 0.011 15.6 0.1 3.9 3 2 0 3 3 3 0 Exportin 1-like protein CBFB_NFYA PF02045.10 KOG99298.1 - 6.7e-28 96.9 9.0 1.6e-27 95.7 6.2 1.7 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B GIDA PF01134.17 KOG99299.1 - 7.3e-159 528.8 0.0 9.6e-159 528.4 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc_3 PF13932.1 KOG99299.1 - 1.6e-20 72.8 0.0 9.9e-20 70.3 0.0 2.4 3 0 0 3 3 3 1 GidA associated domain 3 FAD_oxidored PF12831.2 KOG99299.1 - 7.8e-07 28.5 0.4 1.3e-06 27.8 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOG99299.1 - 1.7e-06 28.0 0.2 3.4e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOG99299.1 - 1.9e-06 27.0 0.6 0.038 12.8 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOG99299.1 - 0.00046 20.5 0.2 0.0011 19.2 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KOG99299.1 - 0.003 17.3 0.6 0.0061 16.3 0.0 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 KOG99299.1 - 0.0039 16.0 3.3 0.013 14.3 1.6 2.0 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 KOG99299.1 - 0.018 13.5 1.4 0.15 10.5 0.4 2.2 2 0 0 2 2 2 0 HI0933-like protein AlaDh_PNT_C PF01262.16 KOG99299.1 - 0.034 13.7 0.1 0.061 12.8 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.1 KOG99299.1 - 0.079 13.2 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox_3 PF13738.1 KOG99299.1 - 0.098 12.7 0.1 0.38 10.7 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOG99299.1 - 0.15 10.9 0.1 1.3 7.8 0.2 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein GARS_A PF01071.14 KOG99300.1 - 7.3e-81 270.3 0.0 1.3e-80 269.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.10 KOG99300.1 - 1.2e-32 112.3 0.1 1e-31 109.3 0.0 2.5 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.17 KOG99300.1 - 2.8e-31 108.6 0.0 5.8e-31 107.5 0.0 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.11 KOG99300.1 - 6e-27 93.6 0.4 1.4e-26 92.4 0.3 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.19 KOG99300.1 - 5e-14 52.3 1.3 5e-14 52.3 0.9 2.6 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain ATPgrasp_Ter PF15632.1 KOG99300.1 - 6.1e-06 25.2 0.0 1.2e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_4 PF13535.1 KOG99300.1 - 1.2e-05 25.1 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 KOG99300.1 - 0.026 14.3 0.2 0.11 12.3 0.0 2.1 2 0 0 2 2 2 0 ATP-grasp domain ATP-grasp_2 PF08442.5 KOG99300.1 - 0.083 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp PF02222.17 KOG99300.1 - 0.089 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain Sec15 PF04091.7 KOG99301.1 - 2.5e-109 365.3 4.9 2.5e-109 365.3 3.4 2.3 2 1 0 2 2 2 1 Exocyst complex subunit Sec15-like DUF1077 PF06417.7 KOG99302.1 - 5.6e-47 158.1 5.1 7.1e-47 157.8 3.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Rhamno_transf PF11316.3 KOG99303.1 - 0.018 14.2 0.0 0.052 12.7 0.0 1.7 2 0 0 2 2 2 0 Putative rhamnosyl transferase SAPS PF04499.10 KOG99304.1 - 9.5e-147 489.4 7.8 1.6e-146 488.7 5.4 1.4 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein SPRY PF00622.23 KOG99306.1 - 8.8e-27 93.6 0.3 3.5e-26 91.7 0.1 2.2 2 0 0 2 2 2 1 SPRY domain CLTH PF10607.4 KOG99306.1 - 7.7e-13 48.3 5.1 1.1e-12 47.8 2.8 1.8 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.6 KOG99306.1 - 0.0011 18.6 0.0 0.0038 16.9 0.0 2.0 1 0 0 1 1 1 1 LisH CENP-T PF15511.1 KOG99306.1 - 0.0052 16.0 12.1 0.016 14.4 6.4 2.4 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T Daxx PF03344.10 KOG99306.1 - 1.2 7.5 24.0 0.025 13.1 9.0 2.2 2 0 0 2 2 2 0 Daxx Family COX4 PF02936.9 KOG99307.1 - 3.1e-07 30.2 0.0 3.6e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Coiled PF05710.7 KOG99307.1 - 0.096 13.1 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 Coiled coil Tegument_dsDNA PF12818.2 KOG99308.1 - 0.11 11.3 0.1 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 dsDNA viral tegument protein SRP1_TIP1 PF00660.12 KOG99309.1 - 8.3e-32 109.1 0.1 1.1e-31 108.7 0.0 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family UAA PF08449.6 KOG99310.1 - 7.5e-17 61.1 24.4 9.2e-17 60.8 16.9 1.1 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOG99310.1 - 5.3e-10 39.1 9.8 5.3e-10 39.1 6.8 2.7 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOG99310.1 - 0.0025 17.8 32.1 0.061 13.3 9.6 2.4 2 0 0 2 2 2 2 EamA-like transporter family PHO4 PF01384.15 KOG99310.1 - 0.044 12.4 8.4 0.05 12.2 1.3 2.8 2 1 0 2 2 2 0 Phosphate transporter family HAD_2 PF13419.1 KOG99311.1 - 2.9e-23 82.9 0.0 3.7e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOG99311.1 - 0.0016 18.9 0.0 0.1 13.0 0.0 2.1 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Acid_PPase PF12689.2 KOG99311.1 - 0.0028 17.3 0.1 0.068 12.8 0.0 2.3 2 0 0 2 2 2 1 Acid Phosphatase Vps51 PF08700.6 KOG99312.1 - 0.0053 16.5 4.6 0.0073 16.1 0.3 3.1 4 0 0 4 4 4 1 Vps51/Vps67 Smoothelin PF12510.3 KOG99312.1 - 0.067 13.0 0.1 0.18 11.6 0.0 1.8 1 0 0 1 1 1 0 Smoothelin cytoskeleton protein SR-25 PF10500.4 KOG99313.1 - 0.038 13.4 26.6 0.054 12.9 18.3 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ndc1_Nup PF09531.5 KOG99313.1 - 0.57 8.5 11.9 0.68 8.2 8.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF2217 PF10265.4 KOG99313.1 - 2 7.1 8.1 2.4 6.8 5.6 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) SRP-alpha_N PF04086.8 KOG99313.1 - 2.1 7.6 9.0 2.8 7.2 6.2 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Med13_C PF06333.7 KOG99313.1 - 2.5 6.5 9.3 2.9 6.3 6.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal Macoilin PF09726.4 KOG99313.1 - 3.2 5.9 13.1 3.6 5.7 9.1 1.1 1 0 0 1 1 1 0 Transmembrane protein Apt1 PF10351.4 KOG99313.1 - 3.4 6.4 9.9 4 6.1 6.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4614 PF15391.1 KOG99313.1 - 4.7 6.9 12.3 2.3 7.9 6.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) RPA_C PF08784.6 KOG99313.1 - 6.4 7.2 8.8 2.2 8.7 2.6 2.4 1 1 1 2 2 2 0 Replication protein A C terminal Tmemb_cc2 PF10267.4 KOG99313.1 - 9.1 4.7 8.4 11 4.4 5.8 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein NIF3 PF01784.13 KOG99314.1 - 1.4e-61 208.1 0.0 1.6e-61 207.9 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) tRNA-synt_1c_C PF03950.13 KOG99315.1 - 0.054 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), anti-codon binding domain Kinesin PF00225.18 KOG99316.1 - 5e-114 380.4 2.4 5e-114 380.4 1.7 1.7 2 0 0 2 2 2 1 Kinesin motor domain AAA_24 PF13479.1 KOG99316.1 - 0.019 14.5 0.0 0.14 11.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain Cyclin PF08613.6 KOG99317.1 - 2.9e-06 27.7 0.1 5.9e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 Cyclin WD40 PF00400.27 KOG99318.1 - 2e-14 52.8 22.1 2.2e-07 30.4 2.0 6.2 7 0 0 7 7 7 4 WD domain, G-beta repeat eIF2A PF08662.6 KOG99318.1 - 0.014 15.0 0.0 0.061 13.0 0.0 1.9 1 1 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.1 KOG99318.1 - 0.081 12.6 0.0 9 6.1 0.0 2.6 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region PX PF00787.19 KOG99319.1 - 1.9e-14 53.4 0.6 5.9e-14 51.8 0.1 1.9 2 0 0 2 2 2 1 PX domain SNARE PF05739.14 KOG99319.1 - 3e-12 46.0 7.2 8.3e-12 44.6 5.0 1.8 1 0 0 1 1 1 1 SNARE domain ATP_bind_3 PF01171.15 KOG99320.1 - 5.4e-18 65.1 0.0 1.1e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 PP-loop family DUF2392 PF10288.4 KOG99320.1 - 7e-05 23.1 0.0 0.00019 21.7 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF2392) MU117 PF15474.1 KOG99320.1 - 0.0065 16.9 2.0 0.0065 16.9 1.4 1.9 2 0 0 2 2 2 1 Meiotically up-regulated gene family tRNA_Me_trans PF03054.11 KOG99320.1 - 0.017 13.6 0.0 0.033 12.7 0.0 1.5 1 1 0 1 1 1 0 tRNA methyl transferase PAPS_reduct PF01507.14 KOG99320.1 - 0.062 13.1 0.0 0.28 10.9 0.0 2.0 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family Ribosomal_S14 PF00253.16 KOG99320.1 - 9.5 5.6 12.0 0.48 9.8 1.0 3.2 3 0 0 3 3 3 0 Ribosomal protein S14p/S29e Ras PF00071.17 KOG99321.1 - 8e-60 200.8 0.3 9.4e-60 200.6 0.2 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG99321.1 - 6.6e-20 71.7 0.1 9.5e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOG99321.1 - 3.2e-13 49.2 0.0 4.3e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOG99321.1 - 1.6e-07 31.3 0.1 2.5e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.1 KOG99321.1 - 7.4e-06 25.2 0.1 8.2e-06 25.1 0.1 1.2 1 0 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.22 KOG99321.1 - 1.1e-05 24.9 0.1 2.4e-05 23.8 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KOG99321.1 - 0.00032 19.9 0.0 0.0004 19.5 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.11 KOG99321.1 - 0.00054 19.1 0.0 0.0011 18.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SRPRB PF09439.5 KOG99321.1 - 0.0022 17.2 0.0 0.0031 16.7 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit KAP_NTPase PF07693.9 KOG99321.1 - 0.0023 16.9 0.0 0.0031 16.5 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain AAA_22 PF13401.1 KOG99321.1 - 0.0095 16.0 0.1 0.022 14.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOG99321.1 - 0.02 14.8 0.2 0.092 12.7 0.2 2.0 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.13 KOG99321.1 - 0.026 13.7 0.0 0.048 12.9 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B ABC_tran PF00005.22 KOG99321.1 - 0.03 14.6 0.2 0.043 14.1 0.2 1.4 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.4 KOG99321.1 - 0.065 12.7 0.0 0.14 11.6 0.0 1.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.13 KOG99321.1 - 0.066 12.2 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_14 PF13173.1 KOG99321.1 - 0.078 12.8 0.1 0.16 11.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain TraG_N PF07916.6 KOG99321.1 - 0.097 11.0 0.0 0.12 10.8 0.0 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region AAA_29 PF13555.1 KOG99321.1 - 0.12 11.9 0.0 0.34 10.4 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain zf-H2C2_2 PF13465.1 KOG99322.1 - 3.4e-10 39.6 18.6 3.8e-06 26.9 3.7 3.4 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 KOG99322.1 - 5.1e-08 32.7 18.4 5.6e-06 26.3 2.6 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG99322.1 - 6.8e-06 26.0 13.6 5e-05 23.3 0.9 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOG99322.1 - 0.00055 19.9 6.3 0.091 12.9 0.5 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding RPAP2_Rtr1 PF04181.8 KOG99322.1 - 0.22 11.6 3.0 0.23 11.5 0.1 2.4 2 0 0 2 2 2 0 Rtr1/RPAP2 family zf-met PF12874.2 KOG99322.1 - 0.25 11.6 4.3 2.9 8.2 0.6 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type PAT1 PF09770.4 KOG99322.1 - 2.1 6.4 24.9 3 5.9 17.3 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 zf-C2HC_2 PF13913.1 KOG99322.1 - 5.2 6.8 7.7 3.1 7.5 0.2 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type AMPKBI PF04739.10 KOG99323.1 - 1.8e-32 111.2 3.4 4e-32 110.0 2.4 1.6 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interation domain SPT16 PF08644.6 KOG99324.1 - 2.6e-51 173.4 0.2 8.2e-51 171.8 0.2 1.9 1 0 0 1 1 1 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.1 KOG99324.1 - 4.9e-49 166.0 3.2 2.1e-48 163.9 0.1 2.7 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.19 KOG99324.1 - 4.7e-25 88.3 0.0 8.1e-25 87.6 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.7 KOG99324.1 - 1.1e-18 66.9 0.1 5.1e-18 64.8 0.1 2.2 1 0 0 1 1 1 1 Histone chaperone Rttp106-like Clathrin PF00637.15 KOG99325.1 - 2e-199 653.1 57.8 2.5e-33 114.7 1.6 8.4 9 0 0 9 9 9 7 Region in Clathrin and VPS Clathrin_H_link PF13838.1 KOG99325.1 - 5e-25 87.1 1.3 1.4e-24 85.7 0.2 2.4 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.15 KOG99325.1 - 3.9e-18 64.4 3.6 0.00025 21.1 0.1 5.7 5 0 0 5 5 5 5 Clathrin propeller repeat Clathrin-link PF09268.5 KOG99325.1 - 1.5e-08 33.4 0.3 1.5e-08 33.4 0.2 3.2 4 0 0 4 4 4 1 Clathrin, heavy-chain linker TPR_7 PF13176.1 KOG99325.1 - 0.00062 19.3 3.1 15 5.7 0.0 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOG99325.1 - 6.1 7.2 8.7 18 5.7 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat ACOX PF01756.14 KOG99326.1 - 7.5e-53 178.6 0.0 1.5e-52 177.6 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.14 KOG99326.1 - 6.5e-17 60.7 0.3 1.3e-16 59.8 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.1 KOG99326.1 - 4.1e-10 40.0 0.0 2e-09 37.8 0.0 2.1 1 1 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.19 KOG99326.1 - 0.0016 18.5 0.0 0.024 14.7 0.0 2.3 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Peptidase_S10 PF00450.17 KOG99327.1 - 8.4e-106 354.5 0.1 1.3e-105 354.0 0.1 1.3 1 0 0 1 1 1 1 Serine carboxypeptidase Glycophorin_A PF01102.13 KOG99327.1 - 0.063 13.0 0.0 0.2 11.4 0.0 1.8 1 0 0 1 1 1 0 Glycophorin A Aminotran_1_2 PF00155.16 KOG99328.1 - 9.8e-19 67.5 0.0 1.3e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOG99328.1 - 0.13 11.3 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 KOG99328.1 - 0.13 11.2 0.2 0.36 9.8 0.0 1.6 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family MCM PF00493.18 KOG99329.1 - 3.2e-137 456.7 0.3 4.7e-137 456.2 0.2 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 KOG99329.1 - 3.5e-21 75.9 0.4 2.1e-20 73.4 0.0 2.5 3 0 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.16 KOG99329.1 - 2.1e-07 30.2 0.0 7.2e-07 28.5 0.0 1.9 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 KOG99329.1 - 0.0038 16.7 0.0 0.008 15.6 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.6 KOG99329.1 - 0.014 15.0 0.1 0.047 13.2 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOG99329.1 - 0.061 13.0 0.0 0.15 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) EMP24_GP25L PF01105.19 KOG99330.1 - 2.1e-43 148.1 0.0 2.4e-43 147.9 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Lsr2 PF11774.3 KOG99330.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Lsr2 Yip1 PF04893.12 KOG99331.1 - 1.2e-12 47.6 11.4 1.6e-12 47.2 7.9 1.2 1 0 0 1 1 1 1 Yip1 domain Kelch_6 PF13964.1 KOG99332.1 - 2.4e-16 59.0 0.4 2.4e-07 30.6 0.0 5.0 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 KOG99332.1 - 1.6e-14 53.1 3.2 3.3e-07 29.7 0.0 4.6 4 1 0 4 4 4 3 Kelch motif Kelch_4 PF13418.1 KOG99332.1 - 5.2e-14 51.7 3.6 8.3e-05 22.2 0.0 6.2 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.1 KOG99332.1 - 3.8e-11 42.8 1.3 0.00012 22.1 0.0 5.3 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KOG99332.1 - 2.8e-09 36.3 0.5 6.8e-06 25.6 0.0 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.1 KOG99332.1 - 6.4e-05 22.8 0.1 0.011 15.6 0.0 3.6 3 0 0 3 3 3 1 Kelch motif Serinc PF03348.10 KOG99332.1 - 0.69 8.5 1.7 1.2 7.7 1.2 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) D-ser_dehydrat PF14031.1 KOG99333.1 - 1.8e-19 69.7 0.0 3.2e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.15 KOG99333.1 - 6.8e-12 45.4 0.0 1.2e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DUF3554 PF12074.3 KOG99334.1 - 3.7e-54 184.4 5.5 3.7e-54 184.4 3.8 6.2 7 1 0 7 7 7 1 Domain of unknown function (DUF3554) HEAT_2 PF13646.1 KOG99334.1 - 3.1e-34 117.0 27.1 3.8e-08 33.4 0.0 13.5 10 4 5 15 15 15 8 HEAT repeats HEAT_EZ PF13513.1 KOG99334.1 - 1.4e-28 98.6 21.2 0.0036 17.7 0.9 17.0 12 3 6 19 19 19 6 HEAT-like repeat HEAT PF02985.17 KOG99334.1 - 5.7e-28 94.4 33.4 0.0044 16.9 0.0 19.4 25 0 0 25 25 25 8 HEAT repeat CLASP_N PF12348.3 KOG99334.1 - 8.2e-20 71.1 0.9 0.0016 17.8 0.0 9.6 8 1 2 11 11 11 4 CLASP N terminal Vac14_Fab1_bd PF12755.2 KOG99334.1 - 1.2e-12 48.0 1.1 0.065 13.6 0.0 9.1 9 1 1 10 10 10 3 Vacuolar 14 Fab1-binding region Hist_deacetyl PF00850.14 KOG99336.1 - 5e-81 272.3 0.0 6.4e-81 272.0 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain MT-A70 PF05063.9 KOG99337.1 - 8.4e-56 188.2 0.2 8.4e-56 188.2 0.1 1.9 2 0 0 2 2 2 1 MT-A70 COX6A PF02046.10 KOG99338.1 - 1.5e-40 137.7 0.6 1.6e-40 137.6 0.4 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa DUF2741 PF10890.3 KOG99338.1 - 0.08 13.0 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2741) WD40 PF00400.27 KOG99339.1 - 1.5e-16 59.5 0.1 0.0014 18.3 0.0 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat Mem_trans PF03547.13 KOG99339.1 - 4.1 5.5 6.3 6.6 4.9 4.4 1.2 1 0 0 1 1 1 0 Membrane transport protein Ribosomal_S26e PF01283.14 KOG99340.1 - 2.4e-50 169.5 8.3 2.9e-50 169.2 5.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e DUF1101 PF06503.6 KOG99340.1 - 0.016 14.0 0.1 0.017 13.9 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1101) COX5B PF01215.14 KOG99341.1 - 1.2e-60 203.0 0.0 1.5e-60 202.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb Transp_cyt_pur PF02133.10 KOG99342.1 - 3.2e-17 62.2 35.4 3.2e-17 62.2 24.5 2.0 2 0 0 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin 2-Hacid_dh_C PF02826.14 KOG99343.1 - 2.3e-31 108.3 0.0 3.4e-31 107.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 KOG99343.1 - 8.1e-06 25.3 0.0 1.5e-05 24.4 0.0 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 KOG99343.1 - 0.00064 19.6 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.11 KOG99343.1 - 0.0032 16.9 0.0 0.0074 15.7 0.0 1.7 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Cys_Met_Meta_PP PF01053.15 KOG99344.1 - 3.4e-129 430.4 0.0 4e-129 430.2 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Mnd1 PF03962.10 KOG99345.1 - 1.1e-37 129.4 12.9 1.3e-37 129.3 8.9 1.0 1 0 0 1 1 1 1 Mnd1 family CHASE3 PF05227.8 KOG99345.1 - 0.017 14.7 2.2 0.017 14.7 1.5 1.5 1 1 0 1 1 1 0 CHASE3 domain RasGAP_C PF03836.10 KOG99345.1 - 0.031 13.9 8.4 0.05 13.2 5.8 1.3 1 0 0 1 1 1 0 RasGAP C-terminus DUF2684 PF10885.3 KOG99345.1 - 0.037 13.8 0.0 12 5.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2684) Img2 PF05046.9 KOG99345.1 - 0.44 10.8 3.2 1.3 9.3 2.2 2.0 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) DUF3735 PF12537.3 KOG99345.1 - 0.44 10.6 2.4 1 9.4 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3735) Snf7 PF03357.16 KOG99345.1 - 0.96 8.8 11.2 1.8 7.9 7.8 1.5 1 1 0 1 1 1 0 Snf7 ArfGap PF01412.13 KOG99346.1 - 7.7e-29 99.8 0.0 7.7e-29 99.8 0.0 2.8 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf UBA PF00627.26 KOG99346.1 - 6.1e-09 35.4 0.0 6.1e-09 35.4 0.0 2.2 2 0 0 2 2 2 1 UBA/TS-N domain Med15 PF09606.5 KOG99346.1 - 1.3e-05 23.7 70.6 1.6e-05 23.3 48.9 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Cellulose_synt PF03552.9 KOG99346.1 - 3.5 5.7 4.3 4.6 5.4 3.0 1.1 1 0 0 1 1 1 0 Cellulose synthase Erythro_esteras PF05139.9 KOG99346.1 - 4 6.5 21.8 27 3.8 0.0 2.2 2 0 0 2 2 2 0 Erythromycin esterase EPL1 PF10513.4 KOG99346.1 - 5.9 7.1 12.3 11 6.1 8.5 1.5 1 0 0 1 1 1 0 Enhancer of polycomb-like PAT1 PF09770.4 KOG99346.1 - 6.7 4.8 57.6 8.6 4.4 39.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3543 PF12063.3 KOG99347.1 - 1.2e-63 214.5 9.7 2.6e-62 210.1 6.7 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.20 KOG99347.1 - 1.6e-60 204.4 0.0 6.7e-60 202.4 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99347.1 - 7.1e-45 153.0 0.0 1.4e-44 152.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG99347.1 - 0.017 14.0 0.0 0.33 9.8 0.0 2.3 2 0 0 2 2 2 0 Kinase-like APH PF01636.18 KOG99347.1 - 0.038 13.7 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.20 KOG99348.1 - 3.8e-65 219.6 0.0 4.9e-65 219.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99348.1 - 9.7e-34 116.5 0.0 1.5e-33 115.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG99348.1 - 3.3e-09 36.1 0.0 6e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 KOG99348.1 - 0.036 12.9 0.0 0.15 10.8 0.0 1.9 2 0 0 2 2 2 0 Seadornavirus VP7 Kdo PF06293.9 KOG99348.1 - 0.18 10.8 0.0 1.4 7.9 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PUF PF00806.14 KOG99349.1 - 1.6e-58 190.9 31.5 2.3e-08 33.0 0.1 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat BSMAP PF12280.3 KOG99351.1 - 1.2 9.0 4.5 0.44 10.3 1.2 1.6 2 0 0 2 2 2 0 Brain specific membrane anchored protein Bud13 PF09736.4 KOG99352.1 - 4.1e-25 88.7 6.3 4.1e-25 88.7 4.4 2.9 2 1 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex TOM20_plant PF06552.7 KOG99352.1 - 0.35 10.4 3.4 1.2 8.6 0.0 3.0 2 1 2 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 XRN_N PF03159.13 KOG99353.1 - 6.9e-103 343.1 0.3 6.9e-103 343.1 0.2 2.3 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus Nucleoporin_FG PF13634.1 KOG99354.1 - 3.4e-22 78.8 123.0 4.5e-09 36.5 41.2 4.7 2 1 2 4 4 4 3 Nucleoporin FG repeat region NPV_P10 PF05531.7 KOG99354.1 - 0.057 13.6 4.6 2.7 8.3 0.0 2.6 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.7 KOG99354.1 - 0.35 10.6 3.9 1.5 8.6 0.8 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DEAD PF00270.24 KOG99355.1 - 9.9e-43 145.5 0.3 2.5e-42 144.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG99355.1 - 3.3e-25 87.7 0.1 1.1e-24 86.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOG99355.1 - 5.4e-05 23.0 0.0 5.4e-05 23.0 0.0 2.8 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOG99355.1 - 0.042 14.0 1.3 0.37 10.9 0.9 2.3 1 1 0 1 1 1 0 AAA domain P68HR PF08061.6 KOG99356.1 - 0.0033 17.1 1.5 0.0073 16.0 0.1 2.2 2 0 0 2 2 2 1 P68HR (NUC004) repeat Sua5_yciO_yrdC PF01300.13 KOG99357.1 - 2e-47 160.7 0.0 5.4e-47 159.3 0.0 1.7 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.8 KOG99357.1 - 6.6e-32 110.2 0.0 1.3e-31 109.2 0.0 1.5 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding E1-E2_ATPase PF00122.15 KOG99358.1 - 5.8e-78 261.0 0.7 5.8e-78 261.0 0.5 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 KOG99358.1 - 2.9e-47 160.5 1.3 2.9e-47 160.5 0.9 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 KOG99358.1 - 5.8e-31 108.5 0.0 1.4e-30 107.3 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOG99358.1 - 1.2e-19 69.9 0.0 2.7e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 KOG99358.1 - 6e-17 62.4 0.0 1.2e-16 61.4 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 KOG99358.1 - 3.4e-16 58.4 0.0 9.7e-16 57.0 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 KOG99358.1 - 6e-05 22.7 0.3 0.0059 16.2 0.2 2.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Copper-fist PF00649.13 KOG99359.1 - 3.8e-21 73.9 1.0 3.8e-21 73.9 0.7 2.4 1 1 1 2 2 2 1 Copper fist DNA binding domain Cucumo_2B PF03263.8 KOG99359.1 - 0.084 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Cucumovirus protein 2B VESA1_N PF12785.2 KOG99359.1 - 0.64 8.9 11.9 0.78 8.6 8.2 1.1 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 Ran-binding PF05508.6 KOG99360.1 - 4.7e-121 403.3 5.9 4.7e-121 403.3 4.1 1.5 2 0 0 2 2 2 1 RanGTP-binding protein TRAP-gamma PF07074.7 KOG99360.1 - 0.0034 16.9 0.5 0.0087 15.6 0.1 1.8 1 1 1 2 2 2 1 Translocon-associated protein, gamma subunit (TRAP-gamma) Laminin_II PF06009.7 KOG99360.1 - 0.044 13.5 0.6 0.044 13.5 0.4 2.8 3 0 0 3 3 3 0 Laminin Domain II Daxx PF03344.10 KOG99360.1 - 0.1 11.0 22.7 0.19 10.1 15.7 1.4 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 KOG99360.1 - 0.32 8.9 13.7 0.81 7.6 9.5 1.7 1 0 0 1 1 1 0 CDC45-like protein CENP-T PF15511.1 KOG99360.1 - 0.35 10.0 10.7 0.55 9.4 7.4 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T TRAP_alpha PF03896.11 KOG99360.1 - 0.99 8.3 11.9 3.2 6.6 8.2 1.8 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SNF2_N PF00176.18 KOG99361.1 - 4.4e-70 235.8 0.0 6.8e-70 235.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.5 KOG99361.1 - 7.8e-56 188.9 2.0 1.9e-55 187.6 1.2 1.8 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.26 KOG99361.1 - 8e-14 51.2 0.0 2.5e-13 49.6 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 KOG99361.1 - 5.7e-10 38.4 2.3 1e-08 34.3 0.1 3.0 2 2 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 KOG99361.1 - 2e-05 24.1 0.0 4.6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOG99361.1 - 0.0039 17.0 0.0 0.02 14.7 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF1170 PF06663.8 KOG99361.1 - 0.019 14.8 0.0 0.072 13.0 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1170) Zn_clus PF00172.13 KOG99363.1 - 0.00099 18.9 3.6 0.00099 18.9 2.5 3.0 3 0 0 3 3 3 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Yip1 PF04893.12 KOG99364.1 - 2.2e-07 30.5 0.4 4.4e-07 29.5 0.2 1.6 1 1 0 1 1 1 1 Yip1 domain DUF2427 PF10348.4 KOG99364.1 - 7.9e-05 22.1 0.3 0.00021 20.8 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF2427) IBD PF10416.4 KOG99364.1 - 0.029 14.1 0.0 0.061 13.1 0.0 1.5 1 0 0 1 1 1 0 Transcription-initiator DNA-binding domain IBD NAD_binding_6 PF08030.7 KOG99365.1 - 2e-20 73.3 0.0 3e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 KOG99365.1 - 2.3e-18 66.4 9.6 2.3e-18 66.4 6.7 2.4 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 KOG99365.1 - 2.3e-13 49.9 0.0 5e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain OCD_Mu_crystall PF02423.10 KOG99366.1 - 5.3e-09 35.2 0.0 0.0016 17.2 0.0 2.4 2 0 0 2 2 2 2 Ornithine cyclodeaminase/mu-crystallin family Pkinase PF00069.20 KOG99367.1 - 1.1e-58 198.4 0.0 1.7e-58 197.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99367.1 - 2.5e-24 85.7 0.0 5.4e-23 81.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG99367.1 - 1.2e-06 27.7 0.1 1.1e-05 24.5 0.0 2.2 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG99367.1 - 0.00052 19.1 0.0 0.00085 18.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Epimerase PF01370.16 KOG99368.1 - 2.6e-15 56.4 0.0 4.4e-15 55.7 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KOG99368.1 - 1.2e-10 40.5 0.0 1.6e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 KOG99368.1 - 1.6e-09 37.0 0.5 2e-08 33.4 0.4 2.0 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 KOG99368.1 - 3e-07 30.6 0.5 6.8e-07 29.4 0.4 1.6 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 KOG99368.1 - 8.6e-07 29.0 0.0 1.6e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOG99368.1 - 9.4e-05 22.1 0.0 0.00017 21.3 0.0 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 KOG99368.1 - 0.00025 20.0 0.2 0.00051 19.0 0.1 1.5 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.8 KOG99368.1 - 0.0046 16.2 0.1 0.046 12.9 0.1 2.1 2 0 0 2 2 2 1 NmrA-like family DXP_redisom_C PF08436.7 KOG99368.1 - 0.098 12.5 0.0 1.9 8.3 0.0 3.0 4 0 0 4 4 4 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal Glyco_hydro_38 PF01074.17 KOG99369.1 - 1.8e-86 289.8 0.4 2.7e-86 289.2 0.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.8 KOG99369.1 - 2.1e-70 237.7 3.5 3e-70 237.2 2.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.6 KOG99369.1 - 1.9e-24 85.6 0.0 5e-24 84.3 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase, middle domain Prenyltrans PF00432.16 KOG99370.1 - 5.2e-33 112.2 4.3 1e-07 31.3 0.0 4.7 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 KOG99370.1 - 1.2e-15 57.9 0.1 0.00019 21.8 0.2 3.2 2 1 1 3 3 3 3 Prenyltransferase-like Prenyltrans_1 PF13243.1 KOG99370.1 - 6.6e-06 26.1 0.0 0.058 13.4 0.0 2.3 2 0 0 2 2 2 2 Prenyltransferase-like U3_assoc_6 PF08640.6 KOG99370.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.7 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 6 ACPS PF01648.15 KOG99371.1 - 7.2e-09 35.4 0.0 1.2e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Pex14_N PF04695.8 KOG99372.1 - 1.4e-31 109.3 2.5 1.4e-31 109.3 1.8 3.0 3 1 0 3 3 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region IncA PF04156.9 KOG99372.1 - 5.8e-05 22.7 4.2 9.3e-05 22.0 2.9 1.4 1 0 0 1 1 1 1 IncA protein Mating_N PF12731.2 KOG99372.1 - 0.0054 16.5 0.6 0.013 15.3 0.4 1.7 1 0 0 1 1 1 1 Mating-type protein beta 1 Nsp1_C PF05064.8 KOG99372.1 - 0.0058 16.2 14.0 0.41 10.2 3.1 3.1 1 1 2 3 3 3 2 Nsp1-like C-terminal region UPF0242 PF06785.6 KOG99372.1 - 0.025 13.2 4.3 0.034 12.8 3.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) ATG16 PF08614.6 KOG99372.1 - 0.036 13.8 18.0 5.5 6.7 0.1 3.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Atg14 PF10186.4 KOG99372.1 - 0.037 12.9 2.3 0.059 12.3 1.6 1.4 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 zf-C4H2 PF10146.4 KOG99372.1 - 0.053 13.5 11.2 0.093 12.7 7.8 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein Reo_sigmaC PF04582.7 KOG99372.1 - 0.13 11.4 0.3 0.19 10.8 0.2 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF1043 PF06295.7 KOG99372.1 - 0.14 11.8 7.4 0.28 10.8 2.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) DUF1664 PF07889.7 KOG99372.1 - 0.16 11.7 8.0 0.07 12.9 2.7 2.3 2 1 1 3 3 2 0 Protein of unknown function (DUF1664) SPX PF03105.14 KOG99372.1 - 0.3 10.8 10.7 0.6 9.8 7.4 1.5 1 0 0 1 1 1 0 SPX domain V_ATPase_I PF01496.14 KOG99372.1 - 0.36 8.6 9.2 0.59 7.9 6.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Baculo_PEP_C PF04513.7 KOG99372.1 - 0.41 10.4 10.2 1 9.1 7.0 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus APG6 PF04111.7 KOG99372.1 - 0.51 9.3 14.7 1 8.3 10.2 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 CR6_interact PF10147.4 KOG99372.1 - 0.54 9.5 9.3 0.03 13.6 2.5 1.7 2 1 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 LXG PF04740.7 KOG99372.1 - 0.94 9.2 12.9 2.3 7.9 7.9 2.2 1 1 1 2 2 2 0 LXG domain of WXG superfamily COG2 PF06148.6 KOG99372.1 - 1.9 8.3 8.5 4.2 7.2 0.1 2.6 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Sec34 PF04136.10 KOG99372.1 - 3.2 7.4 10.6 1.4 8.6 3.7 2.3 1 1 1 2 2 2 0 Sec34-like family EMP24_GP25L PF01105.19 KOG99372.1 - 5.5 6.6 9.0 0.71 9.5 2.3 2.1 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD IFT57 PF10498.4 KOG99372.1 - 6.8 5.3 23.8 0.3 9.7 11.3 2.2 2 1 0 2 2 2 0 Intra-flagellar transport protein 57 Spc7 PF08317.6 KOG99372.1 - 8.3 4.9 23.8 1 7.9 12.0 2.4 2 1 0 2 2 2 0 Spc7 kinetochore protein Cytochrom_B562 PF07361.6 KOG99372.1 - 9.9 6.6 15.0 3.9 7.9 2.5 2.9 1 1 0 3 3 3 0 Cytochrome b562 Med5 PF08689.5 KOG99373.1 - 0 1013.7 54.6 0 1013.5 37.9 1.0 1 0 0 1 1 1 1 Mediator complex subunit Med5 SNF2_N PF00176.18 KOG99374.1 - 7.6e-72 241.6 3.9 7.6e-72 241.6 2.7 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.1 KOG99374.1 - 1.6e-52 177.2 25.1 1.6e-52 177.2 17.4 4.1 3 1 0 4 4 4 1 DNA-binding domain Helicase_C PF00271.26 KOG99374.1 - 7.6e-14 51.3 0.0 2.3e-13 49.8 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chorismate_synt PF01264.16 KOG99375.1 - 7.2e-135 448.9 0.0 8.3e-135 448.7 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Ribosomal_L6 PF00347.18 KOG99376.1 - 8.6e-29 99.8 10.0 7.4e-15 55.2 2.5 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 LRR_6 PF13516.1 KOG99376.1 - 0.014 15.3 0.6 0.28 11.3 0.1 2.9 3 0 0 3 3 3 0 Leucine Rich repeat LRR_4 PF12799.2 KOG99376.1 - 0.026 14.1 0.1 1.1 9.0 0.0 2.4 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) EMP24_GP25L PF01105.19 KOG99377.1 - 1e-08 35.1 0.2 1.9e-08 34.2 0.1 1.4 1 1 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF760 PF05542.6 KOG99377.1 - 0.1 12.7 0.2 0.25 11.5 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF760) DBR1 PF05011.8 KOG99377.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain RINT1_TIP1 PF04437.8 KOG99378.1 - 1.7e-112 376.5 24.3 1.7e-112 376.5 16.8 2.1 2 0 0 2 2 2 1 RINT-1 / TIP-1 family PrkA PF06798.7 KOG99378.1 - 0.0084 15.4 1.3 0.0084 15.4 0.9 2.5 4 0 0 4 4 4 1 PrkA serine protein kinase C-terminal domain Terpene_synth_C PF03936.11 KOG99378.1 - 0.011 14.9 3.5 2.3 7.4 0.0 3.2 3 1 0 4 4 4 0 Terpene synthase family, metal binding domain HrpB7 PF09486.5 KOG99378.1 - 2 8.3 8.3 1.5 8.7 1.3 2.3 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF676 PF05057.9 KOG99379.1 - 4.1e-60 202.8 0.0 6.7e-60 202.0 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.20 KOG99379.1 - 0.0026 17.3 0.0 0.0094 15.5 0.0 2.0 1 1 0 1 1 1 1 Lipase (class 3) LCAT PF02450.10 KOG99379.1 - 0.015 14.3 0.6 0.028 13.4 0.0 1.7 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase PGAP1 PF07819.8 KOG99379.1 - 0.016 14.7 0.0 0.037 13.6 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein RF-1 PF00472.15 KOG99380.1 - 8.6e-40 135.0 3.6 2.2e-39 133.7 2.5 1.7 1 0 0 1 1 1 1 RF-1 domain PCRF PF03462.13 KOG99380.1 - 3.1e-31 107.4 0.1 3.7e-30 103.9 0.0 2.4 2 0 0 2 2 2 1 PCRF domain Dynamin_N PF00350.18 KOG99380.1 - 0.018 14.8 1.1 0.047 13.5 0.0 2.0 2 0 0 2 2 2 0 Dynamin family Glyco_transf_22 PF03901.12 KOG99381.1 - 3.1e-133 444.8 31.8 3.7e-133 444.5 22.0 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family HECT PF00632.20 KOG99382.1 - 1.4e-87 293.8 0.7 3e-87 292.7 0.5 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF2422 PF10337.4 KOG99383.1 - 2.4e-92 310.1 11.2 1.4e-91 307.6 0.2 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF2422) FUSC_2 PF13515.1 KOG99383.1 - 2e-13 50.3 13.0 2e-13 50.3 9.0 2.8 2 1 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.3 KOG99383.1 - 1.4e-08 33.7 7.1 7.3e-07 28.1 1.0 2.6 3 0 0 3 3 3 2 Aluminium activated malate transporter DUF2421 PF10334.4 KOG99383.1 - 0.00043 19.9 0.0 0.00079 19.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2421) FUSC PF04632.7 KOG99383.1 - 0.012 14.1 2.3 0.022 13.2 1.6 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF939 PF06081.6 KOG99383.1 - 2.6 7.9 6.9 1.1 9.1 1.2 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF939) TRP PF06011.7 KOG99384.1 - 4.4e-148 493.4 39.6 6.8e-148 492.8 27.4 1.3 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 KOG99384.1 - 6.7e-42 142.8 0.8 6.7e-42 142.8 0.5 1.7 2 0 0 2 2 2 1 ML-like domain E1_DerP2_DerF2 PF02221.10 KOG99384.1 - 0.014 15.6 0.1 0.025 14.7 0.1 1.4 1 0 0 1 1 1 0 ML domain Coatomer_WDAD PF04053.9 KOG99386.1 - 1.3e-163 544.9 0.1 2e-163 544.3 0.1 1.3 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.27 KOG99386.1 - 9.2e-49 161.6 4.7 1.1e-11 44.1 0.0 7.8 7 0 0 7 7 7 6 WD domain, G-beta repeat BBS2_Mid PF14783.1 KOG99386.1 - 0.00016 21.4 0.0 0.34 10.6 0.0 4.3 3 1 2 5 5 5 1 Ciliary BBSome complex subunit 2, middle region TPR_2 PF07719.12 KOG99386.1 - 0.00024 20.7 1.0 0.29 11.1 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOG99386.1 - 0.0052 16.3 0.0 1.8 8.3 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat Poly_export PF02563.11 KOG99386.1 - 0.0089 15.7 0.0 3.6 7.4 0.0 2.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis/export protein Nup160 PF11715.3 KOG99386.1 - 0.0089 14.2 3.1 2.4 6.2 0.0 4.2 4 1 1 5 5 5 1 Nucleoporin Nup120/160 TPR_11 PF13414.1 KOG99386.1 - 0.013 15.1 0.4 0.56 9.9 0.1 2.8 2 0 0 2 2 2 0 TPR repeat TPR_8 PF13181.1 KOG99386.1 - 5.4 7.0 6.4 30 4.7 0.0 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat FtsJ PF01728.14 KOG99387.1 - 1.1e-52 178.6 0.0 1.5e-52 178.2 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.1 KOG99387.1 - 0.00018 21.2 0.0 0.00034 20.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOG99387.1 - 0.038 14.5 0.0 0.099 13.2 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Ribosomal_L1 PF00687.16 KOG99388.1 - 5.2e-44 150.2 1.9 6.4e-44 149.9 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Cyclin PF08613.6 KOG99389.1 - 5.6e-18 65.7 2.4 1.1e-17 64.8 1.7 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 KOG99389.1 - 0.081 12.4 1.1 0.2 11.2 0.8 1.6 1 0 0 1 1 1 0 Cyclin, N-terminal domain HMG-CoA_red PF00368.13 KOG99389.1 - 0.12 11.0 0.1 0.2 10.2 0.1 1.2 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A reductase WAC_Acf1_DNA_bd PF10537.4 KOG99390.1 - 6e-36 122.6 0.4 6e-36 122.6 0.3 2.7 3 0 0 3 3 3 1 ATP-utilising chromatin assembly and remodelling N-terminal DDT PF02791.12 KOG99390.1 - 1.5e-20 72.7 0.3 5.9e-19 67.5 0.1 2.5 2 0 0 2 2 2 1 DDT domain WHIM2 PF15613.1 KOG99390.1 - 5.3e-14 51.4 0.2 5.8e-12 45.0 0.1 3.0 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 2 BAH PF01426.13 KOG99391.1 - 7e-17 61.2 0.6 2.6e-16 59.4 0.1 2.1 2 0 0 2 2 2 1 BAH domain PHD PF00628.24 KOG99391.1 - 7.6e-11 41.5 67.2 4e-06 26.4 5.8 6.1 6 1 1 7 7 7 3 PHD-finger zf-HC5HC2H_2 PF13832.1 KOG99391.1 - 1.2e-10 41.3 7.5 1.2e-10 41.3 5.2 4.8 3 2 0 4 4 4 1 PHD-zinc-finger like domain PHD_2 PF13831.1 KOG99391.1 - 0.00071 18.8 27.9 0.0016 17.7 3.7 4.9 3 1 0 3 3 3 2 PHD-finger mRNA_cap_enzyme PF01331.14 KOG99392.1 - 7.5e-64 214.9 0.1 1.9e-63 213.6 0.0 1.7 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.10 KOG99392.1 - 2.5e-21 75.9 0.4 1.4e-20 73.5 0.3 2.2 1 1 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.16 KOG99392.1 - 1.6e-07 30.8 0.0 1.4e-06 27.7 0.0 2.4 2 1 0 2 2 2 1 ATP dependent DNA ligase domain DUF4420 PF14390.1 KOG99392.1 - 0.02 13.7 0.1 0.042 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4420) DAP3 PF10236.4 KOG99393.1 - 2.7e-85 286.0 1.6 3.7e-85 285.5 1.1 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.1 KOG99393.1 - 2.4e-05 24.3 0.0 4.8e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 KOG99393.1 - 0.0032 17.6 0.1 0.04 14.0 0.1 2.4 1 1 0 1 1 1 1 AAA domain T2SE PF00437.15 KOG99393.1 - 0.0087 14.9 0.0 0.018 13.9 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein Sigma54_activat PF00158.21 KOG99393.1 - 0.0094 15.4 0.0 0.019 14.4 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain DUF258 PF03193.11 KOG99393.1 - 0.017 14.2 0.0 0.037 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 KOG99393.1 - 0.021 14.3 0.0 0.048 13.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.10 KOG99393.1 - 0.046 13.4 1.0 0.23 11.1 0.0 2.6 3 0 0 3 3 3 0 NTPase DnaJ PF00226.26 KOG99394.1 - 6e-16 57.9 0.4 1.1e-15 57.0 0.3 1.5 1 0 0 1 1 1 1 DnaJ domain Acyl-CoA_ox_N PF14749.1 KOG99394.1 - 0.015 15.5 0.4 0.027 14.7 0.3 1.5 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal Med31 PF05669.7 KOG99395.1 - 1.5e-34 117.8 0.6 1.7e-34 117.6 0.4 1.1 1 0 0 1 1 1 1 SOH1 Dam PF05869.6 KOG99395.1 - 0.094 12.1 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) Scs3p PF10261.4 KOG99396.1 - 2e-47 161.2 1.5 2.5e-47 160.9 1.0 1.1 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Chorion_2 PF03964.10 KOG99396.1 - 0.035 14.6 1.3 0.065 13.7 0.9 1.4 1 0 0 1 1 1 0 Chorion family 2 DUF3098 PF11297.3 KOG99396.1 - 0.14 11.8 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3098) Helicase_IV_N PF12462.3 KOG99396.1 - 0.34 10.5 3.2 2.7 7.5 0.0 2.1 2 0 0 2 2 2 0 DNA helicase IV / RNA helicase N terminal MTHFR PF02219.12 KOG99397.1 - 1.2e-124 415.0 0.0 1.7e-124 414.6 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Mon1 PF03164.9 KOG99398.1 - 6.2e-165 548.8 4.2 8.2e-165 548.4 2.9 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 Ribosomal_S5 PF00333.15 KOG99399.1 - 5.9e-29 99.6 5.8 6e-29 99.5 1.6 2.4 3 0 0 3 3 3 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 KOG99399.1 - 1.3e-21 75.5 0.1 2.3e-21 74.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain E3_binding PF02817.12 KOG99399.1 - 0.23 11.1 1.3 0.38 10.4 0.0 2.0 2 0 0 2 2 2 0 e3 binding domain Nab2 PF11517.3 KOG99400.1 - 3.9e-49 165.1 2.4 6.4e-49 164.5 1.6 1.3 1 0 0 1 1 1 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) zf-CCCH_2 PF14608.1 KOG99400.1 - 1.8e-15 56.2 67.1 5e-05 23.1 4.7 7.4 7 0 0 7 7 7 5 Zinc finger C-x8-C-x5-C-x3-H type Ycf1 PF05758.7 KOG99400.1 - 0.00045 18.0 0.4 0.00045 18.0 0.3 1.1 1 0 0 1 1 1 1 Ycf1 PIH1 PF08190.7 KOG99400.1 - 0.013 14.9 15.5 0.026 13.9 10.7 1.4 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 Band_3_cyto PF07565.8 KOG99400.1 - 0.018 14.5 7.3 0.028 13.9 5.1 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PAT1 PF09770.4 KOG99400.1 - 0.045 11.9 40.9 0.071 11.3 28.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SHOCT PF09851.4 KOG99400.1 - 0.06 12.8 0.7 0.15 11.5 0.5 1.7 1 0 0 1 1 1 0 Short C-terminal domain V_ATPase_I PF01496.14 KOG99400.1 - 0.28 8.9 5.6 0.38 8.5 3.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BAF1_ABF1 PF04684.8 KOG99400.1 - 0.33 9.7 22.0 0.48 9.2 15.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4045 PF13254.1 KOG99400.1 - 0.54 9.4 12.2 1.2 8.3 8.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Kei1 PF08552.6 KOG99400.1 - 0.69 9.5 3.5 1.1 8.9 2.4 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DDHD PF02862.12 KOG99400.1 - 1.4 8.7 12.0 2.6 7.7 8.3 1.4 1 0 0 1 1 1 0 DDHD domain Hid1 PF12722.2 KOG99400.1 - 1.5 6.4 11.6 1.9 6.0 8.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pex14_N PF04695.8 KOG99400.1 - 1.6 8.7 21.5 4 7.4 14.9 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2215 PF10225.4 KOG99400.1 - 1.8 7.9 4.1 2.8 7.3 2.8 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) Baculo_PP31 PF05311.6 KOG99400.1 - 2.1 7.5 10.3 3.9 6.6 7.1 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF4557 PF15101.1 KOG99400.1 - 2.2 8.0 20.5 4 7.2 14.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) SeqA PF03925.8 KOG99400.1 - 2.7 7.6 15.0 1.2 8.8 8.7 1.6 2 0 0 2 2 1 0 SeqA protein SprA-related PF12118.3 KOG99400.1 - 2.8 7.1 33.4 4.8 6.4 23.1 1.3 1 0 0 1 1 1 0 SprA-related family FLO_LFY PF01698.11 KOG99400.1 - 3.1 6.5 13.2 5.1 5.8 9.1 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF4407 PF14362.1 KOG99400.1 - 3.3 6.5 17.9 5.6 5.8 12.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TFIIA PF03153.8 KOG99400.1 - 3.6 7.4 31.1 6.6 6.5 21.6 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Dala_Dala_lig_N PF01820.16 KOG99400.1 - 3.8 7.8 6.8 10 6.4 4.7 1.7 1 0 0 1 1 1 0 D-ala D-ala ligase N-terminus Med15 PF09606.5 KOG99400.1 - 3.8 5.5 58.2 5.2 5.1 40.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4011 PF13195.1 KOG99400.1 - 6 6.8 9.7 7.5 6.5 6.1 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF4011) FimP PF09766.4 KOG99400.1 - 6.2 5.7 24.8 11 4.9 17.2 1.3 1 0 0 1 1 1 0 Fms-interacting protein Serinc PF03348.10 KOG99400.1 - 9.4 4.8 10.8 14 4.2 7.5 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) HA2 PF04408.18 KOG99402.1 - 1.1e-26 92.7 0.0 2.3e-26 91.7 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 KOG99402.1 - 1.8e-25 88.9 0.0 4.4e-25 87.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 KOG99402.1 - 6.1e-12 45.2 0.0 1.3e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOG99402.1 - 2e-09 37.1 0.2 3.5e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KOG99402.1 - 2.9e-06 27.4 0.1 1.1e-05 25.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 KOG99402.1 - 0.00027 20.4 0.1 0.00064 19.2 0.1 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain ResIII PF04851.10 KOG99402.1 - 0.00034 20.4 0.3 0.016 15.0 0.1 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.9 KOG99402.1 - 0.0013 18.5 0.1 0.0025 17.5 0.1 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_23 PF13476.1 KOG99402.1 - 0.0069 16.7 0.0 0.062 13.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 KOG99402.1 - 0.013 14.4 0.0 0.029 13.2 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.1 KOG99402.1 - 0.025 14.1 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 KOG99402.1 - 0.088 12.0 0.0 0.32 10.2 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_29 PF13555.1 KOG99402.1 - 0.13 11.7 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC1 PF03109.11 KOG99403.1 - 9.9e-37 125.5 0.0 1.8e-36 124.7 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Abhydrolase_8 PF06259.7 KOG99403.1 - 0.099 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase Arfaptin PF06456.8 KOG99404.1 - 0.00025 20.4 0.2 0.00047 19.5 0.1 1.4 1 0 0 1 1 1 1 Arfaptin-like domain GCN5L1 PF06320.8 KOG99404.1 - 0.051 13.3 0.1 0.32 10.8 0.0 2.2 3 0 0 3 3 3 0 GCN5-like protein 1 (GCN5L1) DUF2762 PF10960.3 KOG99404.1 - 0.11 12.2 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2762) WD40 PF00400.27 KOG99405.1 - 2.3e-22 77.9 15.0 1.7e-07 30.8 0.1 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat CBS PF00571.23 KOG99406.1 - 3.4e-29 100.3 3.6 1.1e-12 47.5 0.1 4.2 4 0 0 4 4 4 4 CBS domain Foamy_BEL PF03274.9 KOG99406.1 - 0.12 11.5 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Foamy virus BEL 1/2 protein OPT PF03169.10 KOG99407.1 - 1.9e-173 578.2 21.4 2.2e-173 578.0 14.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4229 PF14012.1 KOG99407.1 - 2.8 7.9 8.4 5.8 6.8 2.7 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4229) SLD3 PF08639.5 KOG99408.1 - 1.7e-93 313.9 17.2 6e-93 312.1 11.9 1.9 1 1 0 1 1 1 1 DNA replication regulator SLD3 TAF PF02969.12 KOG99409.1 - 9.4e-30 102.3 0.2 2.4e-29 101.0 0.2 1.7 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) DUF1546 PF07571.8 KOG99409.1 - 1.1e-29 102.3 0.0 5.6e-29 100.1 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1546) Histone PF00125.19 KOG99409.1 - 0.00046 20.2 0.1 0.0027 17.7 0.1 2.1 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TAF4 PF05236.9 KOG99409.1 - 0.00083 18.7 0.0 0.002 17.4 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family CENP-S PF15630.1 KOG99409.1 - 0.0032 17.6 1.1 0.6 10.3 0.0 3.2 3 0 0 3 3 3 1 Kinetochore component CENP-S TFIID-31kDa PF02291.10 KOG99409.1 - 0.045 13.5 1.1 0.11 12.3 0.1 2.0 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.18 KOG99409.1 - 0.093 12.8 0.4 0.43 10.6 0.1 2.3 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zf-CHC2 PF01807.15 KOG99410.1 - 0.096 12.2 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 CHC2 zinc finger CUE PF02845.11 KOG99411.1 - 5.5e-09 35.3 0.3 1.4e-08 34.0 0.2 1.8 1 0 0 1 1 1 1 CUE domain CAF-1_p150 PF11600.3 KOG99412.1 - 0.62 9.3 26.4 0.8 9.0 18.3 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF1675 PF07897.6 KOG99412.1 - 3.4 7.4 15.0 4.3 7.1 10.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Asp-B-Hydro_N PF05279.6 KOG99412.1 - 3.6 7.3 15.1 3.9 7.2 10.4 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4407 PF14362.1 KOG99412.1 - 3.6 6.4 12.3 4.3 6.1 8.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Vfa1 PF08432.5 KOG99412.1 - 7.8 6.4 19.1 9.7 6.1 13.3 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PPR PF01535.15 KOG99413.1 - 0.002 17.9 0.4 0.018 15.0 0.0 2.8 3 0 0 3 3 3 1 PPR repeat Rsa3 PF14615.1 KOG99413.1 - 0.015 14.6 0.1 0.11 11.8 0.0 2.5 2 0 0 2 2 2 0 Ribosome-assembly protein 3 EF-hand_7 PF13499.1 KOG99414.1 - 1.2e-14 54.1 1.8 1.5e-09 37.8 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOG99414.1 - 2e-10 39.6 4.7 0.00044 19.8 0.1 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.27 KOG99414.1 - 2e-09 36.0 6.7 0.00022 20.2 0.1 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOG99414.1 - 1.1e-08 34.5 2.8 6.2e-07 28.9 0.1 3.3 3 2 2 5 5 5 1 EF-hand domain pair EF-hand_9 PF14658.1 KOG99414.1 - 1.1e-06 28.4 0.0 0.042 13.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOG99414.1 - 0.042 13.1 3.1 0.4 10.1 0.0 3.2 3 0 0 3 3 3 0 EF hand Orthopox_B11R PF07033.6 KOG99414.1 - 0.11 11.9 0.2 0.33 10.4 0.1 1.7 2 0 0 2 2 2 0 Orthopoxvirus B11R protein tRNA_bind PF01588.15 KOG99415.1 - 1.3e-28 98.6 0.0 2.3e-28 97.8 0.0 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain NARP1 PF12569.3 KOG99415.1 - 0.34 9.5 14.1 0.48 9.1 9.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Sugar_tr PF00083.19 KOG99416.1 - 2e-86 290.3 22.1 2.5e-86 290.0 15.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG99416.1 - 9.5e-24 83.7 24.2 1.7e-18 66.4 4.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ribosomal_L18e PF00828.14 KOG99417.1 - 5.4e-35 120.5 0.1 7.6e-35 120.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 HD_3 PF13023.1 KOG99418.1 - 4.1e-35 120.9 0.2 4.1e-35 120.9 0.2 1.5 2 0 0 2 2 2 1 HD domain HD PF01966.17 KOG99418.1 - 3.2e-06 27.1 0.1 7.3e-06 25.9 0.0 1.6 1 1 0 1 1 1 1 HD domain HD_2 PF12917.2 KOG99418.1 - 0.0014 18.4 0.2 0.0019 17.9 0.1 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme WD40 PF00400.27 KOG99419.1 - 5e-37 124.4 21.4 6.2e-09 35.4 0.0 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat MMR_HSR1 PF01926.18 KOG99420.1 - 2.9e-16 59.4 1.1 1.9e-14 53.6 0.0 2.8 3 0 0 3 3 3 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOG99420.1 - 1.3e-07 31.0 0.5 1.4e-05 24.4 0.0 2.5 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF258 PF03193.11 KOG99420.1 - 0.00065 18.9 0.0 0.0013 17.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AIG1 PF04548.11 KOG99420.1 - 0.0024 17.0 0.1 0.005 15.9 0.1 1.5 1 0 0 1 1 1 1 AIG1 family Miro PF08477.8 KOG99420.1 - 0.031 14.7 3.7 0.081 13.4 0.1 2.9 3 0 0 3 3 3 0 Miro-like protein GTP_EFTU PF00009.22 KOG99420.1 - 0.081 12.3 0.1 9.1 5.6 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 KOG99420.1 - 0.12 12.2 7.3 0.03 14.1 0.6 3.0 3 1 0 3 3 3 0 Dynamin family Use1 PF09753.4 KOG99421.1 - 2.1e-07 30.6 0.8 4.4e-07 29.5 0.3 1.6 1 1 0 1 1 1 1 Membrane fusion protein Use1 DUF1980 PF09323.5 KOG99421.1 - 0.023 14.4 2.9 0.023 14.4 2.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) GvpG PF05120.7 KOG99421.1 - 0.3 10.9 4.2 8.4 6.2 0.3 2.8 2 1 1 3 3 3 0 Gas vesicle protein G adh_short PF00106.20 KOG99422.1 - 2.6e-16 60.0 0.0 4.2e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOG99422.1 - 4.2e-08 33.0 0.0 6.5e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 KOG99422.1 - 0.00031 20.5 0.0 0.00045 20.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase THF_DHG_CYH_C PF02882.14 KOG99422.1 - 0.0031 16.5 1.0 0.0067 15.5 0.7 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.1 KOG99422.1 - 0.0039 17.2 0.1 0.054 13.4 0.1 2.1 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOG99422.1 - 0.024 14.0 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family RCC1 PF00415.13 KOG99423.1 - 1.3e-59 198.1 0.8 5.7e-09 36.0 0.0 7.8 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOG99423.1 - 1.5e-38 129.5 19.3 1.3e-08 34.1 0.0 7.4 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Homeobox_KN PF05920.6 KOG99424.1 - 3.9e-19 68.0 0.9 7.2e-19 67.2 0.6 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.24 KOG99424.1 - 2.8e-07 30.0 0.1 6.4e-07 28.8 0.1 1.6 1 0 0 1 1 1 1 Homeobox domain Sec1 PF00995.18 KOG99425.1 - 1.2e-141 473.2 18.4 1.3e-141 473.0 12.8 1.0 1 0 0 1 1 1 1 Sec1 family HEAT_2 PF13646.1 KOG99425.1 - 0.096 12.9 0.0 0.3 11.4 0.0 1.8 1 0 0 1 1 1 0 HEAT repeats Prp18 PF02840.10 KOG99425.1 - 9.2 6.0 8.5 3.3 7.5 0.2 3.4 3 1 1 4 4 4 0 Prp18 domain UCH_1 PF13423.1 KOG99426.1 - 1.1e-39 136.6 4.1 1.6e-39 136.1 2.9 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.19 KOG99426.1 - 5.1e-30 104.9 0.0 1.9e-29 103.0 0.0 2.0 2 0 0 2 2 2 1 Exonuclease UCH PF00443.24 KOG99426.1 - 8.6e-09 34.8 2.1 2e-08 33.6 1.5 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Spc7 PF08317.6 KOG99427.1 - 1.2e-84 283.7 11.6 2.6e-84 282.6 8.0 1.5 1 0 0 1 1 1 1 Spc7 kinetochore protein DASH_Dam1 PF08653.5 KOG99427.1 - 0.026 14.2 0.1 0.11 12.2 0.0 2.2 1 0 0 1 1 1 0 DASH complex subunit Dam1 FlaC_arch PF05377.6 KOG99427.1 - 0.89 9.4 9.6 1.1 9.1 0.2 3.9 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) ParA PF10609.4 KOG99428.1 - 1.1e-35 121.4 0.0 2.1e-35 120.4 0.0 1.4 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 KOG99428.1 - 1.5e-16 60.3 0.0 2.2e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 KOG99428.1 - 1.1e-06 27.9 0.0 1.6e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.1 KOG99428.1 - 1.1e-06 28.6 0.0 5.7e-06 26.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.10 KOG99428.1 - 0.0001 21.4 0.3 0.0031 16.6 0.0 2.3 2 1 0 2 2 2 1 Anion-transporting ATPase AAA_26 PF13500.1 KOG99428.1 - 0.0085 15.7 0.0 0.095 12.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 KOG99428.1 - 0.013 14.7 0.0 0.024 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_25 PF13481.1 KOG99428.1 - 0.016 14.6 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain TF_Zn_Ribbon PF08271.7 KOG99428.1 - 0.036 13.3 0.4 0.11 11.8 0.3 1.8 1 0 0 1 1 1 0 TFIIB zinc-binding AAA_23 PF13476.1 KOG99428.1 - 0.081 13.2 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 KOG99428.1 - 0.16 10.8 0.1 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain XLF PF09302.6 KOG99429.1 - 2.1e-43 148.0 4.8 3.3e-43 147.4 3.3 1.3 1 0 0 1 1 1 1 XLF (XRCC4-like factor) MF_alpha_N PF05436.6 KOG99430.1 - 7.4e-35 118.4 0.7 9.4e-35 118.1 0.5 1.1 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus MF_alpha PF04648.7 KOG99430.1 - 5.5e-22 76.5 32.5 2.4e-07 30.5 4.0 3.2 3 0 0 3 3 3 3 Yeast mating factor alpha hormone UQ_con PF00179.21 KOG99431.1 - 2.2e-17 62.7 0.1 2.4e-17 62.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 KOG99431.1 - 0.00063 19.6 0.1 0.00069 19.4 0.0 1.2 1 0 0 1 1 1 1 RWD domain MAD PF05557.8 KOG99432.1 - 1e-21 76.8 88.4 4.7e-21 74.5 61.3 1.7 1 1 0 1 1 1 1 Mitotic checkpoint protein SNase PF00565.12 KOG99433.1 - 1.8e-28 98.9 0.0 2.8e-28 98.3 0.0 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue DUF3188 PF11384.3 KOG99433.1 - 0.079 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) MBOAT PF03062.14 KOG99434.1 - 5.3e-67 226.2 29.6 1e-66 225.2 20.5 1.5 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Pkinase PF00069.20 KOG99435.1 - 7.5e-18 64.6 0.1 1.3e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99435.1 - 7.3e-10 38.3 0.0 1.3e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF544 PF04424.8 KOG99436.1 - 4.2e-35 120.1 0.0 7.7e-35 119.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF544) Transglut_i_TM PF14400.1 KOG99436.1 - 0.038 13.4 0.7 0.084 12.3 0.5 1.5 1 0 0 1 1 1 0 Inactive transglutaminase fused to 7 transmembrane helices FHA PF00498.21 KOG99437.1 - 1.9e-06 27.8 0.1 5.5e-06 26.4 0.1 1.9 2 0 0 2 2 2 1 FHA domain Myc_N PF01056.13 KOG99437.1 - 0.3 10.1 7.8 0.46 9.6 5.4 1.2 1 0 0 1 1 1 0 Myc amino-terminal region MPC PF03650.8 KOG99438.1 - 3.6e-48 162.4 0.1 4.1e-48 162.2 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) DUF663 PF04950.7 KOG99438.1 - 0.053 12.4 0.1 0.053 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF663) KxDL PF10241.4 KOG99439.1 - 6.3e-08 32.4 0.3 1.2e-07 31.4 0.2 1.5 2 0 0 2 2 2 1 Uncharacterized conserved protein DEAD PF00270.24 KOG99440.1 - 3.8e-51 172.9 0.1 5.4e-49 165.9 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG99440.1 - 7.2e-31 105.8 0.0 1.1e-28 98.8 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.1 KOG99440.1 - 0.00085 18.4 13.7 0.0018 17.3 0.0 2.5 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit DUF1253 PF06862.7 KOG99440.1 - 0.002 16.5 0.1 0.002 16.5 0.1 3.3 3 1 0 3 3 3 1 Protein of unknown function (DUF1253) AAA_19 PF13245.1 KOG99440.1 - 0.0048 16.6 0.0 0.018 14.7 0.0 2.0 1 1 0 1 1 1 1 Part of AAA domain Vfa1 PF08432.5 KOG99440.1 - 6.4 6.7 23.7 13 5.7 16.4 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 AA_permease_2 PF13520.1 KOG99441.1 - 8.6e-50 169.5 47.7 1e-49 169.2 33.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOG99441.1 - 1.1e-19 70.2 39.5 1.4e-19 69.8 27.4 1.0 1 0 0 1 1 1 1 Amino acid permease Fib_alpha PF08702.5 KOG99442.1 - 0.0068 16.5 11.3 0.021 14.9 7.8 1.9 1 1 0 1 1 1 1 Fibrinogen alpha/beta chain family HOOK PF05622.7 KOG99442.1 - 0.0078 14.0 13.5 0.011 13.5 9.3 1.2 1 0 0 1 1 1 1 HOOK protein HJURP_C PF12347.3 KOG99442.1 - 0.037 13.6 0.6 0.13 11.8 0.2 2.1 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat SseC PF04888.7 KOG99442.1 - 0.046 13.0 0.3 0.046 13.0 0.2 1.5 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family GP41 PF00517.12 KOG99442.1 - 0.17 11.4 14.2 0.44 10.0 9.9 1.8 1 1 0 1 1 1 0 Retroviral envelope protein NPV_P10 PF05531.7 KOG99442.1 - 0.67 10.2 5.3 2.2 8.5 0.3 2.8 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Striatin PF08232.7 KOG99442.1 - 0.68 10.2 14.6 0.8 10.0 8.9 1.9 1 1 1 2 2 2 0 Striatin family Jnk-SapK_ap_N PF09744.4 KOG99442.1 - 0.75 9.7 0.0 0.75 9.7 0.0 2.5 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF641 PF04859.7 KOG99442.1 - 0.97 9.1 14.4 0.79 9.4 4.4 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) IncA PF04156.9 KOG99442.1 - 1.3 8.6 19.8 1.3 8.6 6.6 3.0 2 1 1 3 3 3 0 IncA protein DUF1664 PF07889.7 KOG99442.1 - 1.7 8.4 9.7 0.79 9.5 3.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CENP-Q PF13094.1 KOG99442.1 - 4.8 7.1 17.4 29 4.6 11.9 2.1 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit SlyX PF04102.7 KOG99442.1 - 5.8 7.3 12.9 14 6.0 0.4 2.6 2 0 0 2 2 2 0 SlyX HSF_DNA-bind PF00447.12 KOG99443.1 - 1.5e-34 118.2 3.4 1.5e-34 118.2 2.4 2.4 2 0 0 2 2 2 1 HSF-type DNA-binding AFT PF08731.6 KOG99444.1 - 1.1e-47 160.8 3.5 1.1e-47 160.8 2.4 2.3 2 0 0 2 2 2 1 Transcription factor AFT DBD_Tnp_Mut PF03108.10 KOG99444.1 - 0.00027 20.4 1.6 0.43 10.1 0.0 2.5 2 0 0 2 2 2 2 MuDR family transposase FAD_binding_3 PF01494.14 KOG99444.1 - 0.083 11.9 0.7 0.13 11.3 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain RNA_POL_M_15KD PF02150.11 KOG99445.1 - 1.2e-16 60.0 4.2 1.2e-16 60.0 2.9 2.8 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.13 KOG99445.1 - 5.8e-15 54.6 14.8 6.5e-15 54.4 1.7 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Lar_restr_allev PF14354.1 KOG99445.1 - 0.00021 21.5 2.5 0.0039 17.4 0.2 2.2 2 0 0 2 2 2 1 Restriction alleviation protein Lar Rubredoxin PF00301.15 KOG99445.1 - 0.011 15.5 3.3 25 4.8 0.0 4.0 4 0 0 4 4 4 0 Rubredoxin DZR PF12773.2 KOG99445.1 - 0.013 15.3 7.9 0.2 11.4 0.3 2.4 2 1 0 2 2 2 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.2 KOG99445.1 - 0.017 14.8 11.5 0.95 9.3 2.9 3.1 2 1 1 3 3 3 0 Transposase zinc-ribbon domain zf-UBP PF02148.14 KOG99445.1 - 0.024 14.7 4.0 0.41 10.8 0.3 2.3 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein DUF2387 PF09526.5 KOG99445.1 - 0.024 14.5 3.2 1.2 9.1 0.3 2.4 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) Zn-ribbon_8 PF09723.5 KOG99445.1 - 0.044 13.7 8.7 4.5 7.3 0.0 3.9 4 0 0 4 4 4 0 Zinc ribbon domain C1_4 PF07975.7 KOG99445.1 - 0.057 13.4 11.0 0.28 11.1 0.7 3.0 2 1 1 3 3 3 0 TFIIH C1-like domain zf-CHY PF05495.7 KOG99445.1 - 0.082 13.0 6.4 0.47 10.6 0.9 2.3 2 0 0 2 2 2 0 CHY zinc finger Cytochrome_C7 PF14522.1 KOG99445.1 - 0.096 12.3 3.7 0.16 11.6 0.1 2.3 2 1 0 2 2 2 0 Cytochrome c7 Cytochrom_c3_2 PF14537.1 KOG99445.1 - 0.19 12.0 3.4 0.26 11.6 0.4 2.1 2 0 0 2 2 2 0 Cytochrome c3 IBR PF01485.16 KOG99445.1 - 0.23 11.3 6.9 1.1 9.1 0.3 2.6 2 1 0 2 2 2 0 IBR domain zf-CSL PF05207.8 KOG99445.1 - 0.32 10.5 5.0 2 8.0 0.2 2.3 2 0 0 2 2 2 0 CSL zinc finger GFA PF04828.9 KOG99445.1 - 0.67 9.9 5.4 6.5 6.7 0.7 2.5 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DUF2296 PF10058.4 KOG99445.1 - 0.79 9.5 7.1 0.97 9.2 0.3 2.5 2 1 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) Nudix_N_2 PF14803.1 KOG99445.1 - 1.7 8.3 9.6 3.2 7.5 0.6 3.3 3 0 0 3 3 3 0 Nudix N-terminal Mut7-C PF01927.11 KOG99445.1 - 2.8 7.9 5.6 4.1 7.3 1.1 2.3 1 1 1 2 2 2 0 Mut7-C RNAse domain Rpr2 PF04032.11 KOG99445.1 - 3.8 7.4 9.3 5.1e+02 0.6 6.5 2.7 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain HypA PF01155.14 KOG99445.1 - 4.5 7.0 8.5 29 4.3 3.3 2.9 1 1 0 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-RING_5 PF14634.1 KOG99445.1 - 4.6 7.0 13.4 0.16 11.7 2.5 2.5 2 2 0 2 2 2 0 zinc-RING finger domain RPA_interact_C PF14768.1 KOG99445.1 - 9.4 6.7 10.8 4.1 7.8 0.9 2.5 2 2 0 2 2 2 0 Replication protein A interacting C-terminal Ribosomal_L12 PF00542.14 KOG99446.1 - 2e-21 75.7 12.7 2.8e-21 75.3 6.4 2.3 2 1 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Enoyl_reductase PF12241.3 KOG99446.1 - 0.089 11.7 0.2 0.17 10.8 0.1 1.5 1 0 0 1 1 1 0 Trans-2-enoyl-CoA reductase catalytic region Ribosomal_60s PF00428.14 KOG99446.1 - 8.9 6.7 15.3 0.73 10.2 4.6 2.8 1 1 1 3 3 3 0 60s Acidic ribosomal protein NUDIX PF00293.23 KOG99447.1 - 1.9e-14 53.4 0.0 3.5e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain zf-NADH-PPase PF09297.6 KOG99447.1 - 7.2e-07 28.6 0.1 1.5e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain TGT_C2 PF14810.1 KOG99447.1 - 0.013 15.2 0.0 0.11 12.3 0.0 2.3 2 0 0 2 2 2 0 Patch-forming domain C2 of tRNA-guanine transglycosylase zf-ribbon_3 PF13248.1 KOG99447.1 - 0.045 12.9 0.1 0.12 11.6 0.0 1.7 1 0 0 1 1 1 0 zinc-ribbon domain NUDIX-like PF09296.6 KOG99447.1 - 0.074 13.4 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 NADH pyrophosphatase-like rudimentary NUDIX domain SCA7 PF08313.7 KOG99448.1 - 7.8e-35 118.3 0.9 7.8e-35 118.3 0.6 3.1 3 1 0 3 3 3 1 SCA7, zinc-binding domain CENP-T PF15511.1 KOG99448.1 - 0.00038 19.8 15.5 0.00038 19.8 10.7 3.1 3 0 0 3 3 3 1 Centromere kinetochore component CENP-T CDC45 PF02724.9 KOG99448.1 - 0.0027 15.8 22.7 0.0027 15.8 15.7 3.3 3 0 0 3 3 3 1 CDC45-like protein Glycos_transf_1 PF00534.15 KOG99449.1 - 3.5e-50 169.7 0.1 5.8e-50 169.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 KOG99449.1 - 1.5e-09 37.7 0.0 6.3e-09 35.7 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.1 KOG99449.1 - 4.5e-06 26.8 0.0 0.00036 20.7 0.0 2.4 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 KOG99449.1 - 0.00012 22.3 0.0 0.00041 20.5 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain DEAD PF00270.24 KOG99450.1 - 6.3e-33 113.6 0.4 3.3e-32 111.3 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG99450.1 - 9.3e-16 57.4 0.0 4.7e-15 55.2 0.0 2.2 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOG99450.1 - 2.9e-08 33.7 0.5 5e-07 29.7 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KOG99450.1 - 7.3e-08 31.5 0.3 1.2e-07 30.8 0.2 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.1 KOG99450.1 - 0.066 13.3 0.3 0.44 10.6 0.2 2.3 1 1 0 1 1 1 0 AAA domain Helicase_C_2 PF13307.1 KOG99450.1 - 0.11 12.4 0.1 14 5.6 0.0 2.8 2 1 1 3 3 3 0 Helicase C-terminal domain PseudoU_synth_1 PF01416.15 KOG99451.1 - 1.4e-25 89.7 0.0 2.5e-12 47.1 0.0 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase PG_binding_2 PF08823.6 KOG99451.1 - 0.031 14.3 0.0 0.22 11.6 0.0 2.2 2 0 0 2 2 2 0 Putative peptidoglycan binding domain CPSase_L_D2 PF02786.12 KOG99452.1 - 1.2e-84 282.7 0.1 2.2e-84 281.9 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.13 KOG99452.1 - 2e-65 219.8 0.0 3.4e-65 219.1 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain CPSase_L_chain PF00289.17 KOG99452.1 - 1.9e-36 124.4 0.1 4.2e-36 123.3 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 KOG99452.1 - 8.8e-31 106.0 0.0 2.9e-30 104.3 0.0 2.0 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.14 KOG99452.1 - 3.1e-30 105.5 0.1 6.8e-30 104.4 0.1 1.6 1 0 0 1 1 1 1 HMGL-like ATPgrasp_Ter PF15632.1 KOG99452.1 - 1.3e-19 70.1 0.1 8.2e-19 67.5 0.0 2.3 3 1 0 3 3 3 1 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl PF00364.17 KOG99452.1 - 4.3e-19 67.9 2.5 4.3e-19 67.9 1.7 2.2 3 0 0 3 3 2 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 KOG99452.1 - 2.1e-17 63.4 0.2 4e-17 62.5 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 KOG99452.1 - 3.4e-08 33.0 2.1 0.00082 18.9 0.1 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.17 KOG99452.1 - 5.6e-08 32.3 0.0 1.1e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 KOG99452.1 - 3.1e-07 30.0 0.0 6.2e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 KOG99452.1 - 1.1e-05 25.3 0.0 2.9e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.6 KOG99452.1 - 4.7e-05 22.9 0.0 0.00019 20.9 0.0 1.9 1 1 0 1 1 1 1 RimK-like ATP-grasp domain HlyD PF00529.15 KOG99452.1 - 9e-05 21.9 0.8 0.061 12.6 0.0 2.8 3 0 0 3 3 3 2 HlyD family secretion protein HlyD_3 PF13437.1 KOG99452.1 - 0.00037 20.8 0.1 0.32 11.3 0.0 3.0 2 0 0 2 2 2 1 HlyD family secretion protein RnfC_N PF13375.1 KOG99452.1 - 0.0037 16.9 1.5 0.12 12.0 0.2 2.9 2 0 0 2 2 2 1 RnfC Barrel sandwich hybrid domain HlyD_2 PF12700.2 KOG99452.1 - 0.013 14.6 0.4 2.4 7.2 0.1 2.4 1 1 1 2 2 2 0 HlyD family secretion protein NQRA PF05896.6 KOG99452.1 - 0.031 13.4 0.1 0.056 12.6 0.1 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) DASH_Duo1 PF08651.5 KOG99453.1 - 6.3e-27 92.9 1.0 6.3e-27 92.9 0.7 2.4 1 1 1 2 2 2 1 DASH complex subunit Duo1 Cbl_N PF02262.11 KOG99453.1 - 0.2 11.3 2.1 0.78 9.4 1.5 2.0 1 1 0 1 1 1 0 CBL proto-oncogene N-terminal domain 1 Bap31 PF05529.7 KOG99453.1 - 5.3 6.4 8.2 1 8.8 3.0 1.7 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like BCDHK_Adom3 PF10436.4 KOG99454.1 - 2.6e-35 121.3 1.0 4.5e-35 120.5 0.6 1.5 1 1 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 KOG99454.1 - 1.2e-07 31.4 0.0 0.0082 15.8 0.0 2.5 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4170 PF13773.1 KOG99454.1 - 0.073 12.9 0.0 0.22 11.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4170) HATPase_c_3 PF13589.1 KOG99454.1 - 0.1 12.2 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UQ_con PF00179.21 KOG99455.1 - 1.2e-50 170.5 0.1 1.4e-50 170.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOG99455.1 - 6.9e-06 25.8 0.0 8.7e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KOG99455.1 - 0.023 14.5 0.2 0.077 12.8 0.1 1.8 1 1 0 1 1 1 0 RWD domain UEV PF05743.8 KOG99455.1 - 0.031 13.9 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 UEV domain Nucleoplasmin PF03066.10 KOG99455.1 - 8.7 5.8 11.0 12 5.4 7.6 1.2 1 0 0 1 1 1 0 Nucleoplasmin COX4 PF02936.9 KOG99456.1 - 0.00032 20.4 0.0 0.003 17.3 0.0 2.2 2 0 0 2 2 2 1 Cytochrome c oxidase subunit IV CBS PF00571.23 KOG99457.1 - 4.3e-21 74.4 0.7 6e-05 22.7 0.1 5.3 5 0 0 5 5 5 5 CBS domain FA_desaturase PF00487.19 KOG99458.1 - 5.8e-19 68.5 19.5 5.8e-19 68.5 13.5 1.6 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.23 KOG99458.1 - 1e-14 54.0 0.0 3.4e-14 52.4 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Cornichon PF03311.9 KOG99459.1 - 1.6e-51 173.7 8.9 1.9e-51 173.5 6.1 1.0 1 0 0 1 1 1 1 Cornichon protein TYW3 PF02676.9 KOG99460.1 - 9.2e-66 220.8 0.0 1.2e-65 220.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 MIF4G PF02854.14 KOG99461.1 - 1.4e-49 168.3 0.3 2.8e-49 167.3 0.2 1.5 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.3 KOG99461.1 - 1.8e-25 88.5 0.7 6.5e-25 86.8 0.5 2.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 AAA PF00004.24 KOG99462.1 - 1.6e-43 148.0 0.0 2.9e-43 147.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOG99462.1 - 4e-07 29.8 0.0 1.8e-06 27.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 KOG99462.1 - 5.2e-07 29.7 0.0 1.2e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 KOG99462.1 - 3.9e-06 27.0 0.1 0.00028 21.0 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOG99462.1 - 2.3e-05 24.4 0.0 7.2e-05 22.8 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 KOG99462.1 - 4e-05 24.4 0.3 0.00013 22.7 0.0 2.0 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 KOG99462.1 - 0.00014 20.9 0.0 0.00025 20.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 KOG99462.1 - 0.00015 21.4 0.1 0.00031 20.4 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 KOG99462.1 - 0.00024 20.5 0.0 0.00044 19.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 KOG99462.1 - 0.00058 19.7 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOG99462.1 - 0.0019 18.2 0.0 0.0035 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOG99462.1 - 0.0019 18.1 0.0 0.0039 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOG99462.1 - 0.0028 16.7 0.0 0.0067 15.5 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin DUF2072 PF09845.4 KOG99462.1 - 0.0029 17.5 1.5 0.0077 16.1 1.0 1.7 1 0 0 1 1 1 1 Zn-ribbon containing protein (DUF2072) AAA_3 PF07726.6 KOG99462.1 - 0.0054 16.3 0.0 0.015 14.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 KOG99462.1 - 0.0061 16.8 0.8 0.031 14.5 0.0 2.5 3 1 0 3 3 3 1 AAA domain TIP49 PF06068.8 KOG99462.1 - 0.0083 14.8 0.2 0.022 13.4 0.0 1.8 2 0 0 2 2 2 1 TIP49 C-terminus Mg_chelatase PF01078.16 KOG99462.1 - 0.011 14.9 0.0 0.025 13.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.11 KOG99462.1 - 0.012 14.8 0.0 0.046 12.9 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein Sigma54_activat PF00158.21 KOG99462.1 - 0.027 13.9 0.0 0.15 11.5 0.0 2.2 2 1 1 3 3 3 0 Sigma-54 interaction domain AAA_25 PF13481.1 KOG99462.1 - 0.029 13.7 0.1 0.1 12.0 0.0 1.7 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.1 KOG99462.1 - 0.029 13.9 0.0 0.07 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOG99462.1 - 0.032 14.3 0.0 0.07 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Sipho_Gp157 PF05565.6 KOG99462.1 - 0.059 12.9 1.8 0.076 12.5 0.5 1.9 2 0 0 2 2 1 0 Siphovirus Gp157 NACHT PF05729.7 KOG99462.1 - 0.064 12.9 0.0 0.35 10.4 0.0 2.1 1 1 1 2 2 2 0 NACHT domain DUF815 PF05673.8 KOG99462.1 - 0.083 11.7 0.0 0.16 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Parvo_NS1 PF01057.12 KOG99462.1 - 0.087 11.6 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Glyco_tran_28_C PF04101.11 KOG99463.1 - 6.4e-31 107.2 0.0 1.3e-30 106.2 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 KOG99463.1 - 0.023 13.8 0.0 0.028 13.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 1 Arrestin_N PF00339.24 KOG99464.1 - 1e-27 96.7 1.7 2.3e-27 95.6 0.1 2.3 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 KOG99464.1 - 1.2e-08 35.1 0.2 1.2e-08 35.1 0.1 3.1 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain RRM_1 PF00076.17 KOG99465.1 - 3.4e-20 71.4 0.0 6e-20 70.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG99465.1 - 6.9e-15 54.7 0.0 1.3e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG99465.1 - 6.8e-11 41.8 0.0 1.1e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.1 KOG99465.1 - 4.6e-07 29.0 0.8 9.6e-07 27.9 0.5 1.4 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal CSTF2_hinge PF14327.1 KOG99465.1 - 0.0032 17.4 0.2 0.0088 16.1 0.0 1.9 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 Med30 PF11315.3 KOG99465.1 - 0.0088 16.1 0.2 0.017 15.2 0.1 1.4 1 0 0 1 1 1 1 Mediator complex subunit 30 Menin PF05053.8 KOG99465.1 - 5 5.1 8.0 6.9 4.6 5.6 1.1 1 0 0 1 1 1 0 Menin TFIIS_M PF07500.9 KOG99466.1 - 3.1e-26 91.6 0.9 4.4e-26 91.1 0.1 1.7 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.13 KOG99466.1 - 1.8e-17 62.6 6.3 3.2e-17 61.8 4.4 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.6 KOG99466.1 - 5.1e-15 54.7 0.9 1.1e-14 53.6 0.6 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Ribosomal_S27 PF01599.14 KOG99466.1 - 0.26 11.1 2.5 2.1 8.2 0.1 2.4 2 0 0 2 2 2 0 Ribosomal protein S27a Zn_Tnp_IS1595 PF12760.2 KOG99466.1 - 1.7 8.5 5.5 6.1 6.7 3.9 1.8 1 1 0 1 1 1 0 Transposase zinc-ribbon domain ComZ PF10815.3 KOG99467.1 - 0.0015 18.2 0.4 0.0031 17.2 0.3 1.6 1 0 0 1 1 1 1 ComZ ALAD PF00490.16 KOG99468.1 - 1.4e-114 382.4 0.0 1.6e-114 382.1 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Epimerase PF01370.16 KOG99469.1 - 2.6e-14 53.2 0.0 3.8e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KOG99469.1 - 7.2e-12 44.5 0.0 8.7e-12 44.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 KOG99469.1 - 1.2e-09 37.5 0.0 4.6e-09 35.5 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 KOG99469.1 - 2.1e-06 27.8 0.2 4.1e-06 26.9 0.1 1.6 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 KOG99469.1 - 2e-05 24.5 0.0 3.6e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOG99469.1 - 4.6e-05 23.1 0.0 8.7e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 KOG99469.1 - 0.00056 18.9 0.2 0.00076 18.4 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 KOG99469.1 - 0.00074 18.8 0.0 0.0063 15.7 0.0 2.0 2 0 0 2 2 2 1 NmrA-like family Gly_transf_sug PF04488.10 KOG99470.1 - 1.7e-13 50.8 0.0 4.6e-13 49.4 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Isochorismatase PF00857.15 KOG99471.1 - 2.6e-29 102.3 0.1 4e-29 101.7 0.1 1.3 1 1 0 1 1 1 1 Isochorismatase family DUF771 PF05595.6 KOG99471.1 - 0.097 12.5 0.2 0.2 11.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF771) zf-H2C2_2 PF13465.1 KOG99473.1 - 2e-07 30.9 15.2 1.2e-05 25.3 1.2 3.4 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 KOG99473.1 - 2.1e-06 27.7 12.8 0.0045 17.2 0.9 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG99473.1 - 0.00038 20.5 12.9 0.055 13.8 0.7 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger Ribosomal_L24e PF01246.15 KOG99476.1 - 4.4e-33 112.9 0.4 4.4e-33 112.9 0.3 2.0 2 1 0 2 2 2 1 Ribosomal protein L24e Ribosomal_L7Ae PF01248.21 KOG99477.1 - 7.9e-07 28.5 0.0 8e-07 28.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Cgr1 PF03879.9 KOG99478.1 - 1.2e-36 125.2 28.1 1.4e-36 124.9 19.5 1.0 1 0 0 1 1 1 1 Cgr1 family DUF2095 PF09868.4 KOG99478.1 - 0.017 14.8 2.6 0.021 14.5 1.8 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) DRY_EERY PF09750.4 KOG99478.1 - 0.089 12.8 7.3 0.11 12.5 5.1 1.3 1 0 0 1 1 1 0 Alternative splicing regulator DUF342 PF03961.8 KOG99478.1 - 1.7 7.0 10.1 1.7 6.9 7.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Macoilin PF09726.4 KOG99479.1 - 1.4 7.0 33.4 2.3 6.3 23.1 1.2 1 0 0 1 1 1 0 Transmembrane protein Phyto_Pns9_10 PF05878.6 KOG99479.1 - 6 5.7 10.9 18 4.2 7.7 1.8 2 0 0 2 2 2 0 Phytoreovirus nonstructural protein Pns9/Pns10 Glyco_hydro_63 PF03200.11 KOG99480.1 - 1.1e-211 704.8 6.9 2.9e-211 703.4 4.8 1.5 1 1 0 1 1 1 1 Mannosyl oligosaccharide glucosidase GDE_C PF06202.9 KOG99480.1 - 0.00028 19.7 0.1 0.0024 16.6 0.0 2.3 2 1 0 3 3 3 1 Amylo-alpha-1,6-glucosidase Trp_syntA PF00290.15 KOG99481.1 - 6.9e-99 329.5 0.1 1e-98 329.0 0.1 1.2 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.20 KOG99481.1 - 1.1e-42 146.3 1.6 2.1e-42 145.4 0.3 1.9 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme PcrB PF01884.12 KOG99481.1 - 0.025 13.8 0.2 0.16 11.2 0.0 2.1 2 0 0 2 2 2 0 PcrB family Med3 PF11593.3 KOG99482.1 - 1.3e-121 406.4 39.0 1.4e-121 406.3 27.1 1.0 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal FYVE PF01363.16 KOG99483.1 - 1.8e-15 56.5 6.2 4.2e-15 55.3 4.3 1.6 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.11 KOG99483.1 - 1.6 8.6 10.8 5 7.0 7.5 1.9 1 1 0 1 1 1 0 AN1-like Zinc finger STT3 PF02516.9 KOG99484.1 - 3.4e-142 474.8 51.7 2.4e-140 468.7 33.1 2.0 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit DUF3635 PF12330.3 KOG99485.1 - 1.7e-29 101.7 0.5 8.6e-29 99.5 0.4 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3635) Pkinase PF00069.20 KOG99485.1 - 0.00014 21.0 0.2 0.00033 19.9 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 KOG99485.1 - 0.0037 17.0 0.0 0.0063 16.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family MADF_DNA_bdg PF10545.4 KOG99485.1 - 0.77 9.9 5.5 0.15 12.2 0.5 2.3 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like CHD5 PF04420.9 KOG99486.1 - 9.7e-52 174.8 5.4 1.6e-51 174.1 3.8 1.3 1 1 0 1 1 1 1 CHD5-like protein AAA_21 PF13304.1 KOG99486.1 - 0.0016 18.4 0.1 0.0022 18.0 0.1 1.1 1 0 0 1 1 1 1 AAA domain IncA PF04156.9 KOG99486.1 - 0.015 14.8 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 IncA protein DUF4446 PF14584.1 KOG99486.1 - 0.22 11.3 2.1 3.5 7.4 1.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) CK_II_beta PF01214.13 KOG99487.1 - 1e-73 246.7 2.0 3.2e-73 245.1 1.4 1.7 1 1 0 1 1 1 1 Casein kinase II regulatory subunit TRAP_alpha PF03896.11 KOG99487.1 - 0.19 10.7 2.0 0.27 10.2 1.4 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit HSCB_C PF07743.8 KOG99488.1 - 3.7e-16 59.3 7.0 5.9e-15 55.4 1.4 2.1 2 0 0 2 2 2 2 HSCB C-terminal oligomerisation domain DnaJ PF00226.26 KOG99488.1 - 2.1e-15 56.2 0.3 5e-15 54.9 0.2 1.7 1 0 0 1 1 1 1 DnaJ domain Ran_BP1 PF00638.13 KOG99488.1 - 0.05 13.6 0.0 0.077 13.0 0.0 1.3 1 0 0 1 1 1 0 RanBP1 domain Pterin_4a PF01329.14 KOG99488.1 - 0.23 11.2 4.0 4 7.2 0.1 3.1 2 1 1 3 3 3 0 Pterin 4 alpha carbinolamine dehydratase DUF2630 PF10944.3 KOG99488.1 - 0.95 9.6 4.9 0.41 10.7 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) Syntaxin PF00804.20 KOG99488.1 - 2.2 8.5 8.2 32 4.7 5.7 2.2 1 1 0 1 1 1 0 Syntaxin V_ATPase_I PF01496.14 KOG99488.1 - 8.8 4.0 7.6 1.8 6.3 0.5 1.9 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family ATE_C PF04377.10 KOG99489.1 - 2.7e-44 150.3 1.4 4.7e-44 149.5 1.0 1.5 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.8 KOG99489.1 - 6.6e-24 83.5 0.7 1.8e-23 82.1 0.5 1.8 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus PUF PF00806.14 KOG99492.1 - 7.6e-67 217.2 18.8 6.8e-10 37.8 0.1 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Fungal_trans PF04082.13 KOG99493.1 - 4.5e-60 202.7 6.6 4.5e-60 202.7 4.6 2.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOG99493.1 - 3.9e-09 36.2 15.3 3.9e-09 36.2 10.6 2.5 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ERG4_ERG24 PF01222.12 KOG99494.1 - 6.9e-191 634.4 31.5 7.9e-191 634.2 21.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Proteasome PF00227.21 KOG99495.1 - 9.5e-47 158.7 0.0 1.4e-46 158.1 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KOG99495.1 - 1.9e-15 55.8 0.1 3.4e-15 55.0 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF962 PF06127.6 KOG99496.1 - 1.8e-28 98.2 0.0 3.3e-28 97.4 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Aconitase PF00330.15 KOG99497.1 - 2.3e-196 652.8 0.1 2.9e-196 652.4 0.1 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 KOG99497.1 - 3.3e-47 159.8 0.0 7.5e-47 158.7 0.0 1.7 1 0 0 1 1 1 1 Aconitase C-terminal domain E1-E2_ATPase PF00122.15 KOG99498.1 - 6.6e-63 211.8 5.7 1.6e-62 210.5 4.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 KOG99498.1 - 4.8e-24 85.9 0.0 1.1e-23 84.8 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOG99498.1 - 3.5e-14 53.4 0.0 1.2e-13 51.6 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 KOG99498.1 - 8.3e-11 41.1 0.8 2e-10 40.0 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 KOG99498.1 - 0.0015 18.2 0.1 0.0034 16.9 0.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOG99498.1 - 0.012 15.5 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit MLANA PF14991.1 KOG99498.1 - 3.5 7.6 4.7 0.89 9.5 0.2 2.3 2 0 0 2 2 2 0 Protein melan-A E1-E2_ATPase PF00122.15 KOG99500.1 - 1.9e-57 193.9 0.9 1.9e-57 193.9 0.6 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 KOG99500.1 - 1.5e-41 141.9 9.7 1.5e-41 141.9 6.7 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 KOG99500.1 - 4.8e-25 89.2 0.0 9e-19 68.7 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOG99500.1 - 3.5e-14 52.5 0.0 1.1e-13 50.9 0.0 1.9 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 KOG99500.1 - 5.2e-14 52.8 0.0 1.2e-13 51.6 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 KOG99500.1 - 2.2e-06 27.0 0.0 7.6e-06 25.3 0.0 2.0 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 KOG99500.1 - 0.00028 20.5 0.3 0.00028 20.5 0.2 2.9 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase LURAP PF14854.1 KOG99501.1 - 0.019 14.7 1.0 0.042 13.5 0.4 1.9 1 1 0 1 1 1 0 Leucine rich adaptor protein DUF4175 PF13779.1 KOG99501.1 - 0.027 12.2 0.0 0.034 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Peptidase_M19 PF01244.16 KOG99501.1 - 0.052 12.4 0.1 0.068 12.0 0.1 1.2 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) DUF1664 PF07889.7 KOG99501.1 - 0.096 12.4 3.3 0.19 11.5 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.7 KOG99501.1 - 0.3 10.8 8.4 0.045 13.4 1.8 2.2 1 1 1 2 2 2 0 Laminin Domain II TMF_TATA_bd PF12325.3 KOG99501.1 - 0.75 9.5 8.4 0.6 9.8 1.3 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding End3 PF12761.2 KOG99501.1 - 0.92 9.1 9.2 1.6 8.3 0.5 2.3 1 1 1 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 COG2 PF06148.6 KOG99501.1 - 2.3 8.1 7.1 2.7 7.8 0.7 3.1 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 NPV_P10 PF05531.7 KOG99501.1 - 2.3 8.5 9.5 0.14 12.3 0.8 3.0 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FlxA PF14282.1 KOG99501.1 - 9.7 6.1 16.3 1.2 9.1 1.2 3.3 3 0 0 3 3 3 0 FlxA-like protein WD40 PF00400.27 KOG99502.1 - 1.8e-22 78.3 1.9 1e-07 31.5 0.0 5.2 6 0 0 6 6 6 4 WD domain, G-beta repeat WD40 PF00400.27 KOG99503.1 - 6.6e-30 101.8 4.5 2.6e-06 27.1 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.6 KOG99503.1 - 2.1e-07 30.8 0.7 0.00045 19.9 0.2 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A EMP24_GP25L PF01105.19 KOG99504.1 - 2.8e-49 167.3 1.3 3.2e-49 167.1 0.9 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2846 PF11008.3 KOG99504.1 - 0.05 13.4 0.0 0.083 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2846) DUF1128 PF06569.6 KOG99504.1 - 0.054 13.2 0.3 0.11 12.2 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) Remorin_C PF03763.8 KOG99504.1 - 0.097 12.2 1.5 0.15 11.5 1.0 1.2 1 0 0 1 1 1 0 Remorin, C-terminal region 3Beta_HSD PF01073.14 KOG99505.1 - 4.9e-95 317.4 0.0 5.9e-95 317.1 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 KOG99505.1 - 1.6e-31 109.5 0.0 2e-31 109.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 KOG99505.1 - 1.8e-16 59.8 0.0 4.4e-16 58.5 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.12 KOG99505.1 - 4.3e-16 58.6 0.0 7.8e-16 57.7 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 KOG99505.1 - 4.6e-11 43.0 0.0 7e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 KOG99505.1 - 6.9e-10 38.2 0.0 1.5e-09 37.1 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.20 KOG99505.1 - 0.00016 21.6 0.0 0.00057 19.8 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOG99505.1 - 0.0026 17.4 0.0 0.014 15.0 0.0 2.0 1 1 0 1 1 1 1 KR domain NmrA PF05368.8 KOG99505.1 - 0.03 13.5 0.0 0.042 13.1 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family Myb_DNA-bind_6 PF13921.1 KOG99506.1 - 0.0053 16.8 1.0 0.0053 16.8 0.7 2.7 3 0 0 3 3 3 1 Myb-like DNA-binding domain Cullin PF00888.17 KOG99507.1 - 5.7e-103 345.4 18.4 8e-103 344.9 12.8 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 KOG99507.1 - 1.2e-19 69.8 1.1 4.6e-19 68.0 0.8 2.1 1 0 0 1 1 1 1 Cullin protein neddylation domain Pex24p PF06398.6 KOG99508.1 - 1.8e-80 270.4 9.1 2.4e-80 270.0 6.3 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin IGF2_C PF08365.6 KOG99508.1 - 0.017 14.8 0.1 0.046 13.4 0.0 1.7 1 0 0 1 1 1 0 Insulin-like growth factor II E-peptide TFIIF_beta PF02270.10 KOG99509.1 - 2.5e-94 316.1 15.7 4.4e-94 315.3 10.9 1.4 1 0 0 1 1 1 1 Transcription initiation factor IIF, beta subunit Prp18 PF02840.10 KOG99510.1 - 3.5e-43 146.8 0.0 9e-43 145.5 0.0 1.6 1 0 0 1 1 1 1 Prp18 domain CTP_transf_2 PF01467.21 KOG99511.1 - 1.2e-25 90.3 0.1 4.3e-19 69.1 0.1 2.3 2 0 0 2 2 2 2 Cytidylyltransferase FAD_syn PF06574.7 KOG99511.1 - 0.0084 15.7 0.2 6.5 6.3 0.1 3.1 3 0 0 3 3 3 2 FAD synthetase HABP4_PAI-RBP1 PF04774.10 KOG99512.1 - 2.6e-05 24.6 2.3 3.3e-05 24.3 1.6 1.3 1 1 0 1 1 1 1 Hyaluronan / mRNA binding family CTP_transf_2 PF01467.21 KOG99514.1 - 6.5e-36 123.7 0.0 1.2e-35 122.9 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase PALP PF00291.20 KOG99515.1 - 4.3e-62 210.0 0.6 5e-62 209.8 0.4 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme FOP_dimer PF09398.5 KOG99516.1 - 0.0098 15.8 0.0 0.037 14.0 0.0 2.0 1 0 0 1 1 1 1 FOP N terminal dimerisation domain DUF912 PF06024.7 KOG99517.1 - 0.007 16.3 0.0 0.063 13.3 0.0 2.7 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) Abhydrolase_1 PF00561.15 KOG99518.1 - 5.7e-18 65.3 0.0 6.9e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOG99518.1 - 3.1e-17 63.2 0.0 4.8e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 KOG99518.1 - 2.2e-06 28.0 0.0 3.5e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_5 PF12695.2 KOG99518.1 - 7.1e-06 25.8 0.0 1.1e-05 25.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 KOG99518.1 - 0.00051 19.6 0.0 0.0011 18.5 0.0 1.6 2 0 0 2 2 2 1 PGAP1-like protein Esterase PF00756.15 KOG99518.1 - 0.0017 17.8 0.0 0.0033 16.9 0.0 1.4 1 0 0 1 1 1 1 Putative esterase BAAT_C PF08840.6 KOG99518.1 - 0.046 13.4 0.0 0.085 12.5 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF1972 PF09314.6 KOG99518.1 - 0.049 13.0 0.0 0.07 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1972) DUF2974 PF11187.3 KOG99518.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Lipase_3 PF01764.20 KOG99518.1 - 0.13 11.8 0.0 0.28 10.8 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) DUF3687 PF12459.3 KOG99519.1 - 0.82 8.9 3.8 2.5 7.3 0.1 2.4 2 0 0 2 2 2 0 D-Ala-teichoic acid biosynthesis protein Pyridox_oxase_2 PF12766.2 KOG99520.1 - 2.9e-30 104.5 0.1 2.9e-30 104.5 0.1 1.6 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase MCM PF00493.18 KOG99520.1 - 0.055 12.2 0.5 0.084 11.6 0.3 1.2 1 0 0 1 1 1 0 MCM2/3/5 family Sigma70_ner PF04546.8 KOG99520.1 - 0.059 12.9 6.7 0.12 12.0 4.7 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region NOA36 PF06524.7 KOG99520.1 - 1.5 7.9 7.9 2.4 7.3 5.5 1.3 1 0 0 1 1 1 0 NOA36 protein Aminotran_3 PF00202.16 KOG99521.1 - 1.3e-86 290.5 0.0 1.5e-86 290.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III ATP-synt_F PF01990.12 KOG99522.1 - 5e-32 110.1 0.3 5.8e-32 109.9 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DUF257 PF03192.8 KOG99522.1 - 0.056 12.7 0.0 0.066 12.5 0.0 1.1 1 0 0 1 1 1 0 Pyrococcus protein of unknown function, DUF257 Nol1_Nop2_Fmu PF01189.12 KOG99522.1 - 0.11 11.8 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 NOL1/NOP2/sun family Transcrip_reg PF01709.15 KOG99523.1 - 8.2e-73 244.3 1.4 9.7e-73 244.1 1.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator Nif11 PF07862.6 KOG99523.1 - 0.12 12.3 0.1 0.49 10.3 0.0 2.0 2 0 0 2 2 2 0 Nitrogen fixation protein of unknown function Mid2 PF04478.7 KOG99524.1 - 4.7e-69 230.7 0.6 4.7e-69 230.7 0.4 4.6 2 1 2 5 5 5 1 Mid2 like cell wall stress sensor SKG6 PF08693.5 KOG99524.1 - 0.0025 17.1 1.3 0.0025 17.1 0.9 4.2 3 0 0 3 3 3 1 Transmembrane alpha-helix domain DUF912 PF06024.7 KOG99524.1 - 2.3 8.3 5.4 1 9.4 0.0 3.1 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Thg1 PF04446.7 KOG99525.1 - 1.2e-45 154.4 0.3 1.8e-45 153.9 0.2 1.2 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.1 KOG99525.1 - 3.7e-38 129.9 0.2 7.2e-38 128.9 0.2 1.4 1 0 0 1 1 1 1 Thg1 C terminal domain Ribosomal_S25 PF03297.10 KOG99527.1 - 1.8e-44 150.0 3.8 2e-44 149.9 2.6 1.0 1 0 0 1 1 1 1 S25 ribosomal protein Ftsk_gamma PF09397.5 KOG99527.1 - 5.7e-05 22.7 0.0 8.5e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Ftsk gamma domain EAP30 PF04157.11 KOG99527.1 - 0.02 14.0 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family TAF4 PF05236.9 KOG99527.1 - 0.061 12.5 0.1 0.061 12.5 0.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family HTH_CodY PF08222.6 KOG99527.1 - 0.062 12.6 0.1 0.1 11.9 0.1 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain MerR PF00376.18 KOG99527.1 - 0.11 12.0 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 MerR family regulatory protein AAA PF00004.24 KOG99528.1 - 4.3e-39 133.7 0.0 6.7e-39 133.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 KOG99528.1 - 1.9e-07 31.0 0.0 4.2e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOG99528.1 - 2.8e-07 30.7 0.2 0.00023 21.2 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_17 PF13207.1 KOG99528.1 - 4.4e-07 30.7 0.1 1.1e-06 29.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOG99528.1 - 1.7e-06 27.8 0.2 2.5e-05 24.0 0.1 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 KOG99528.1 - 1.9e-06 28.0 0.4 0.0007 19.7 0.0 2.8 2 1 1 3 3 2 1 AAA domain RuvB_N PF05496.7 KOG99528.1 - 3e-06 26.4 0.0 7.9e-06 25.0 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 KOG99528.1 - 4.4e-06 26.7 0.0 9e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 KOG99528.1 - 5.4e-05 23.1 0.0 0.00024 21.0 0.0 2.1 3 1 0 3 3 2 1 AAA domain Zeta_toxin PF06414.7 KOG99528.1 - 0.0001 21.5 0.0 0.00016 20.8 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Sigma54_activ_2 PF14532.1 KOG99528.1 - 0.00018 21.5 0.0 0.00037 20.5 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.1 KOG99528.1 - 0.00024 21.4 0.1 0.00062 20.0 0.0 1.8 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 KOG99528.1 - 0.00041 19.8 0.0 0.00089 18.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 KOG99528.1 - 0.00058 19.0 0.2 0.0016 17.6 0.1 1.6 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 KOG99528.1 - 0.00085 19.4 0.0 0.0019 18.3 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.1 KOG99528.1 - 0.001 18.4 0.7 0.023 14.1 0.1 2.5 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.8 KOG99528.1 - 0.0013 17.7 0.0 0.0021 17.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) NACHT PF05729.7 KOG99528.1 - 0.0029 17.2 0.1 0.0095 15.6 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_28 PF13521.1 KOG99528.1 - 0.0037 17.2 0.0 0.0066 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 KOG99528.1 - 0.0043 16.6 0.0 0.0077 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Bac_DnaA PF00308.13 KOG99528.1 - 0.0057 16.3 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 Bacterial dnaA protein Rad17 PF03215.10 KOG99528.1 - 0.0061 15.2 0.0 0.009 14.7 0.0 1.3 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein TIP49 PF06068.8 KOG99528.1 - 0.0085 14.8 0.1 0.019 13.6 0.0 1.6 1 1 0 1 1 1 1 TIP49 C-terminus ABC_tran PF00005.22 KOG99528.1 - 0.011 16.0 0.0 0.028 14.7 0.0 1.9 1 1 0 1 1 1 0 ABC transporter Arch_ATPase PF01637.13 KOG99528.1 - 0.011 15.4 0.4 0.11 12.2 0.0 2.4 2 1 1 3 3 2 0 Archaeal ATPase Sigma54_activat PF00158.21 KOG99528.1 - 0.011 15.1 0.0 0.041 13.3 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_10 PF12846.2 KOG99528.1 - 0.018 14.5 0.2 1.5 8.1 0.0 2.5 1 1 1 2 2 2 0 AAA-like domain AAA_3 PF07726.6 KOG99528.1 - 0.02 14.4 0.0 0.05 13.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SKI PF01202.17 KOG99528.1 - 0.021 14.7 0.0 0.13 12.1 0.0 2.1 2 0 0 2 2 2 0 Shikimate kinase AAA_19 PF13245.1 KOG99528.1 - 0.022 14.5 0.1 0.064 13.0 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain KAP_NTPase PF07693.9 KOG99528.1 - 0.026 13.5 0.4 1.2 8.0 0.0 2.4 2 1 1 3 3 3 0 KAP family P-loop domain Parvo_NS1 PF01057.12 KOG99528.1 - 0.036 12.9 0.1 0.072 11.9 0.0 1.4 2 0 0 2 2 1 0 Parvovirus non-structural protein NS1 Viral_helicase1 PF01443.13 KOG99528.1 - 0.044 13.3 0.0 0.09 12.2 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.17 KOG99528.1 - 0.065 12.0 0.0 0.11 11.3 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain UPF0079 PF02367.12 KOG99528.1 - 0.066 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 tRNA_lig_kinase PF08303.6 KOG99528.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 tRNA ligase kinase domain DUF4239 PF14023.1 KOG99528.1 - 0.13 11.5 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) KaiC PF06745.8 KOG99528.1 - 0.15 11.1 0.3 1 8.4 0.0 2.3 2 1 1 3 3 3 0 KaiC IPT PF01745.11 KOG99528.1 - 0.15 11.2 0.0 0.27 10.3 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase Alba PF01918.16 KOG99529.1 - 2.8e-08 33.2 0.0 4.6e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Alba CesA PF11439.3 KOG99529.1 - 0.015 15.1 0.9 3 7.8 0.0 2.4 2 1 1 3 3 3 0 Type III secretion system filament chaperone CesA PRD_Mga PF08270.6 KOG99529.1 - 0.13 11.5 3.2 3.8 6.7 0.4 2.1 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) PRD domain Abhydrolase_6 PF12697.2 KOG99530.1 - 3.8e-27 95.6 0.0 4.8e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOG99530.1 - 1.7e-20 73.6 0.0 5.6e-20 71.8 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOG99530.1 - 9.4e-13 48.1 0.0 1.4e-12 47.5 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 KOG99530.1 - 1.8e-10 40.8 0.0 2.6e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Esterase PF00756.15 KOG99530.1 - 0.0001 21.8 0.0 0.0002 20.8 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.3 KOG99530.1 - 0.0059 16.4 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Putative lysophospholipase Thioesterase PF00975.15 KOG99530.1 - 0.0077 16.4 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain DUF676 PF05057.9 KOG99530.1 - 0.012 14.9 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF2048 PF09752.4 KOG99530.1 - 0.044 12.6 0.1 6.2 5.5 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2048) Glucan_synthase PF02364.10 KOG99531.1 - 0 1448.7 0.0 0 1448.3 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 KOG99531.1 - 3.1e-38 130.2 0.0 9.1e-38 128.7 0.0 1.9 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 TIM21 PF08294.6 KOG99532.1 - 2.8e-60 202.1 0.1 3.6e-60 201.8 0.0 1.1 1 0 0 1 1 1 1 TIM21 KOW PF00467.24 KOG99533.1 - 4.5e-05 22.9 0.9 0.00011 21.7 0.6 1.7 1 1 0 1 1 1 1 KOW motif AreA_N PF07573.6 KOG99534.1 - 2.9 8.5 5.1 0.82 10.2 0.8 1.9 1 1 1 2 2 2 0 Nitrogen regulatory protein AreA N terminus PAP2 PF01569.16 KOG99535.1 - 1.6e-19 69.8 0.5 1.6e-19 69.8 0.3 1.7 2 0 0 2 2 2 1 PAP2 superfamily ACBP PF00887.14 KOG99536.1 - 1.5e-29 101.4 1.1 2.2e-29 100.9 0.8 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein ORMDL PF04061.9 KOG99537.1 - 2.5e-58 195.4 7.1 3.1e-58 195.1 5.0 1.1 1 0 0 1 1 1 1 ORMDL family DUF4271 PF14093.1 KOG99537.1 - 0.0022 17.7 0.1 0.0028 17.3 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4271) Pkinase PF00069.20 KOG99538.1 - 2.7e-71 239.7 0.0 3.3e-71 239.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99538.1 - 2.8e-32 111.7 0.0 4.2e-32 111.2 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG99538.1 - 1.3e-06 27.6 0.0 2.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOG99538.1 - 0.002 17.2 0.0 0.0034 16.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG99538.1 - 0.0085 15.8 0.2 0.04 13.6 0.0 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family DUF2439 PF10382.4 KOG99540.1 - 3.7e-26 91.1 1.8 8.9e-26 89.9 1.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) Transaldolase PF00923.14 KOG99541.1 - 1.3e-94 316.5 0.2 1.5e-94 316.3 0.2 1.0 1 0 0 1 1 1 1 Transaldolase InvH PF04741.7 KOG99541.1 - 0.08 12.7 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 InvH outer membrane lipoprotein zf-C2H2_4 PF13894.1 KOG99542.1 - 1.9e-08 34.0 11.4 0.00033 20.7 0.2 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 KOG99542.1 - 0.00051 20.2 0.6 0.00051 20.2 0.4 3.9 4 1 0 4 4 4 2 Zinc finger, C2H2 type zf-Di19 PF05605.7 KOG99542.1 - 0.065 13.3 5.3 9.4 6.4 0.0 3.4 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.1 KOG99542.1 - 0.37 11.1 15.6 1.7 9.0 0.9 4.4 4 1 0 4 4 4 0 Zinc-finger double domain Mmp37 PF09139.6 KOG99543.1 - 4.7e-103 344.6 9.7 1.9e-93 313.1 1.4 2.2 1 1 1 2 2 2 2 Mitochondrial matrix Mmp37 TPR_11 PF13414.1 KOG99544.1 - 1.6e-16 59.6 17.5 2.3e-06 27.1 0.3 7.9 6 2 1 8 8 8 4 TPR repeat TPR_16 PF13432.1 KOG99544.1 - 9.6e-16 57.9 12.3 0.0015 19.1 0.3 7.5 6 2 1 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOG99544.1 - 2.7e-13 48.7 15.9 0.14 12.1 0.1 10.9 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOG99544.1 - 1e-12 48.1 9.1 0.0033 17.7 0.0 6.9 5 2 3 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOG99544.1 - 2.3e-11 43.4 19.1 0.0015 18.4 0.2 6.5 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOG99544.1 - 9.4e-11 41.3 8.2 6.1 7.7 0.2 8.6 6 2 3 9 9 8 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOG99544.1 - 1.4e-10 40.3 12.3 1.7 8.3 0.0 9.2 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOG99544.1 - 2e-09 36.8 7.9 0.26 11.5 0.1 7.5 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOG99544.1 - 8.5e-07 29.0 15.1 0.11 12.9 0.0 7.7 10 0 0 10 10 8 2 Tetratricopeptide repeat Apc3 PF12895.2 KOG99544.1 - 4.3e-06 26.7 18.4 0.59 10.3 0.1 6.2 5 1 1 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.1 KOG99544.1 - 6.5e-05 22.9 0.3 1 9.5 0.0 4.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOG99544.1 - 0.0001 22.1 2.6 0.27 11.1 0.0 5.1 5 1 2 7 7 6 2 Tetratricopeptide repeat Pox_polyA_pol_N PF12630.2 KOG99544.1 - 0.051 13.6 2.3 0.16 12.0 0.0 2.6 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain DUF3273 PF11677.3 KOG99544.1 - 0.069 12.3 0.1 0.14 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3273) TPR_8 PF13181.1 KOG99544.1 - 0.3 10.9 27.2 0.26 11.1 0.1 8.5 10 0 0 10 10 9 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOG99544.1 - 0.32 10.9 6.1 21 5.2 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOG99544.1 - 0.34 10.8 11.0 18 5.4 0.1 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat UFD1 PF03152.9 KOG99545.1 - 9.2e-73 243.1 0.0 1.3e-72 242.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.12 KOG99545.1 - 0.05 13.2 0.3 0.89 9.2 0.0 2.5 3 0 0 3 3 3 0 Cell division protein 48 (CDC48), domain 2 Pkinase PF00069.20 KOG99547.1 - 1.1e-49 168.9 0.0 1.8e-49 168.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99547.1 - 7.1e-26 90.8 0.0 1.5e-25 89.7 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG99547.1 - 4.1e-06 25.9 0.0 8.7e-06 24.8 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOG99547.1 - 0.00019 21.2 0.0 0.28 10.8 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family eIF2A PF08662.6 KOG99549.1 - 9.6e-76 253.8 0.1 3.8e-75 251.8 0.0 2.0 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.27 KOG99549.1 - 0.0017 18.1 0.5 8.2 6.4 0.1 4.7 4 0 0 4 4 4 1 WD domain, G-beta repeat CDV3 PF15359.1 KOG99549.1 - 0.15 12.1 1.9 0.37 10.8 1.3 1.6 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 AA_permease_2 PF13520.1 KOG99550.1 - 9.1e-83 278.1 48.0 1.1e-82 277.8 33.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOG99550.1 - 7.1e-16 57.5 44.0 1.1e-15 57.0 30.5 1.1 1 0 0 1 1 1 1 Amino acid permease Bromodomain PF00439.20 KOG99551.1 - 4.5e-31 106.5 9.4 3.9e-15 55.5 1.5 2.8 2 0 0 2 2 2 2 Bromodomain BAH PF01426.13 KOG99551.1 - 1.6e-25 89.1 0.1 3.2e-25 88.1 0.1 1.5 1 0 0 1 1 1 1 BAH domain CENP-B_dimeris PF09026.5 KOG99551.1 - 0.17 12.1 6.4 0.41 10.8 4.4 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Folliculin PF11704.3 KOG99552.1 - 3.8e-52 176.2 1.3 4.6e-52 176.0 0.9 1.1 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport DUF4334 PF14232.1 KOG99552.1 - 0.12 12.0 0.1 0.4 10.3 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4334) EF-hand_7 PF13499.1 KOG99553.1 - 2.5e-08 33.9 2.9 0.0034 17.4 0.2 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOG99553.1 - 3.2e-07 29.6 1.6 0.088 12.7 0.0 4.4 3 1 1 4 4 4 2 EF-hand domain EF-hand_1 PF00036.27 KOG99553.1 - 4.7e-06 25.5 0.0 6.3 6.3 0.0 4.8 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOG99553.1 - 4.5e-05 22.9 0.1 0.98 9.0 0.0 4.2 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 KOG99553.1 - 0.045 13.0 0.1 8.9 5.8 0.0 3.6 4 0 0 4 4 4 0 EF hand Septin PF00735.13 KOG99554.1 - 5.3e-99 330.7 1.8 5.3e-99 330.7 1.3 1.7 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 KOG99554.1 - 2.4e-05 24.2 0.1 7.9e-05 22.5 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 KOG99554.1 - 0.00068 18.8 2.7 0.0013 17.9 0.2 2.7 2 1 0 2 2 2 1 Protein of unknown function, DUF258 Miro PF08477.8 KOG99554.1 - 0.0082 16.6 0.0 0.045 14.2 0.0 2.3 2 0 0 2 2 1 1 Miro-like protein CCDC92 PF14916.1 KOG99554.1 - 0.01 15.3 5.0 0.031 13.8 3.5 1.8 1 0 0 1 1 1 0 Coiled-coil domain of unknown function S6PP PF05116.8 KOG99554.1 - 0.024 13.9 1.0 0.044 13.0 0.7 1.3 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase AAA_22 PF13401.1 KOG99554.1 - 0.035 14.2 0.0 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 KOG99554.1 - 0.036 13.6 0.0 0.11 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 KOG99554.1 - 0.061 12.2 0.1 0.11 11.3 0.0 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 KOG99554.1 - 0.083 12.3 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family RNA_helicase PF00910.17 KOG99554.1 - 0.16 12.1 2.5 2.5 8.3 0.0 3.0 3 0 0 3 3 3 0 RNA helicase AAA_17 PF13207.1 KOG99554.1 - 3.9 8.3 6.4 16 6.3 1.4 3.4 1 1 1 2 2 2 0 AAA domain FA_hydroxylase PF04116.8 KOG99555.1 - 2.2e-15 57.0 21.1 2.2e-15 57.0 14.6 2.3 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily FDC-SP PF15215.1 KOG99555.1 - 0.02 15.2 1.3 0.052 13.8 0.9 1.7 1 0 0 1 1 1 0 Follicular dendritic cell secreted peptide GATase_5 PF13507.1 KOG99556.1 - 1.5e-96 322.2 0.0 2.3e-96 321.6 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.17 KOG99556.1 - 2.5e-50 170.4 0.3 3.4e-28 98.5 0.0 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.19 KOG99556.1 - 1.4e-21 76.5 0.1 6.1e-21 74.4 0.0 2.1 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain GLYCAM-1 PF05242.6 KOG99556.1 - 0.049 13.5 0.4 0.14 12.1 0.3 1.7 1 0 0 1 1 1 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) Peptidase_C93 PF06035.6 KOG99556.1 - 0.055 12.8 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial transglutaminase-like cysteine proteinase BTLCP 60KD_IMP PF02096.15 KOG99557.1 - 5e-17 62.2 15.1 5.9e-16 58.7 10.4 2.0 1 1 0 1 1 1 1 60Kd inner membrane protein Spt4 PF06093.8 KOG99558.1 - 4.7e-29 100.0 0.6 5.5e-29 99.8 0.4 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger MFS_1 PF07690.11 KOG99559.1 - 2.3e-20 72.6 22.8 3.8e-19 68.6 14.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Vac_ImportDeg PF09783.4 KOG99560.1 - 1.1e-58 197.6 0.6 1.5e-58 197.2 0.4 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein zf-C2H2 PF00096.21 KOG99561.1 - 7.8e-08 32.2 13.1 9.1e-05 22.5 1.5 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOG99561.1 - 8.3e-07 28.9 11.9 0.00046 20.3 1.8 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KOG99561.1 - 0.00065 19.8 13.0 0.0025 17.9 0.9 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-met2 PF12907.2 KOG99561.1 - 0.56 10.2 3.2 5.7 7.0 0.6 2.5 2 0 0 2 2 2 0 Zinc-binding zf-H2C2_5 PF13909.1 KOG99561.1 - 1.1 9.6 8.2 0.12 12.6 1.3 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Arrestin_C PF02752.17 KOG99562.1 - 3e-17 63.0 0.0 2.1e-16 60.2 0.0 2.2 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 KOG99562.1 - 1.1e-06 28.5 0.0 0.00025 20.9 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain CNH PF00780.17 KOG99563.1 - 7.1e-59 199.4 1.2 1.3e-58 198.6 0.8 1.4 1 0 0 1 1 1 1 CNH domain PH_5 PF15405.1 KOG99563.1 - 9.3e-36 122.7 0.1 9.3e-36 122.7 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain RhoGEF PF00621.15 KOG99563.1 - 1.1e-29 103.6 0.2 2.8e-29 102.2 0.1 1.8 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.16 KOG99563.1 - 1.2e-09 37.7 0.0 3.1e-09 36.4 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) zf-BED PF02892.10 KOG99564.1 - 2.7e-08 33.4 1.2 6e-08 32.3 0.8 1.6 1 0 0 1 1 1 1 BED zinc finger Smg4_UPF3 PF03467.10 KOG99565.1 - 9.7e-55 185.2 8.4 9.7e-55 185.2 5.8 2.2 1 1 1 2 2 2 1 Smg-4/UPF3 family DUF4278 PF14105.1 KOG99565.1 - 0.33 10.9 2.7 0.25 11.2 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4278) LSM PF01423.17 KOG99566.1 - 1.1e-21 76.1 0.1 1.6e-21 75.5 0.1 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 KOG99566.1 - 0.0016 18.2 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain PRP38 PF03371.10 KOG99567.1 - 1.2e-45 155.2 2.1 1.5e-45 154.8 1.5 1.0 1 0 0 1 1 1 1 PRP38 family Prefoldin PF02996.12 KOG99570.1 - 1.7e-36 124.4 0.2 2.7e-36 123.8 0.1 1.3 1 0 0 1 1 1 1 Prefoldin subunit DUF4476 PF14771.1 KOG99570.1 - 0.044 13.8 0.1 0.13 12.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) CENP-Q PF13094.1 KOG99570.1 - 0.11 12.5 4.3 0.065 13.2 0.6 2.0 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF1147 PF06615.6 KOG99570.1 - 0.14 11.9 0.2 1.7 8.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1147) Prefoldin_2 PF01920.15 KOG99570.1 - 0.24 11.1 7.4 0.29 10.8 0.1 2.5 3 0 0 3 3 3 0 Prefoldin subunit Lebercilin PF15619.1 KOG99570.1 - 0.35 10.2 5.3 2.8 7.3 1.2 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Cofilin_ADF PF00241.15 KOG99572.1 - 2.8e-40 137.1 0.1 5.6e-19 68.2 0.0 2.3 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Fibroin_P25 PF07294.6 KOG99572.1 - 0.1 12.1 0.0 0.42 10.0 0.0 2.0 2 1 0 2 2 2 0 Fibroin P25 SLX9 PF15341.1 KOG99573.1 - 4.9e-20 72.1 11.3 7.7e-20 71.5 7.9 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 DASH_Spc19 PF08287.6 KOG99573.1 - 0.0077 15.8 0.6 0.016 14.8 0.0 1.8 2 0 0 2 2 2 1 Spc19 MAS20 PF02064.10 KOG99574.1 - 6.8e-19 67.9 0.4 1.2e-17 63.9 0.3 2.0 1 1 0 1 1 1 1 MAS20 protein import receptor IF-2B PF01008.12 KOG99575.1 - 6.3e-111 369.8 0.0 6.3e-111 369.8 0.0 2.1 2 0 0 2 2 2 1 Initiation factor 2 subunit family STb_secrete PF09075.5 KOG99575.1 - 0.03 14.1 0.1 0.23 11.3 0.1 2.2 2 0 0 2 2 2 0 Heat-stable enterotoxin B, secretory Ribosomal_L5_C PF00673.16 KOG99577.1 - 8.4e-23 79.9 0.0 1.3e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 KOG99577.1 - 7.7e-21 73.6 0.2 2.1e-20 72.2 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L5 Pil1 PF13805.1 KOG99578.1 - 4.2e-155 514.7 0.2 5e-155 514.4 0.1 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 TPP_enzyme_M PF00205.17 KOG99579.1 - 6e-33 113.4 0.0 3e-32 111.2 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N PF02776.13 KOG99579.1 - 2.4e-32 111.8 0.0 3.4e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 KOG99579.1 - 2.3e-14 53.2 0.0 4.9e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Catalase PF00199.14 KOG99581.1 - 4.6e-151 502.8 2.1 7.7e-151 502.1 1.5 1.3 1 1 0 1 1 1 1 Catalase Catalase-rel PF06628.7 KOG99581.1 - 4.1e-12 45.7 0.1 2.3e-11 43.3 0.0 2.3 3 0 0 3 3 3 1 Catalase-related immune-responsive DivIC PF04977.10 KOG99582.1 - 0.00043 19.7 2.5 0.00043 19.7 1.7 5.0 5 0 0 5 5 5 2 Septum formation initiator DUF1664 PF07889.7 KOG99582.1 - 0.42 10.4 18.3 0.14 11.9 5.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF2198 PF09964.4 KOG99582.1 - 0.64 9.8 3.5 2.2 8.0 0.4 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) Laminin_II PF06009.7 KOG99582.1 - 1.4 8.6 24.4 1.5 8.5 6.8 2.8 2 1 1 3 3 3 0 Laminin Domain II RasGAP_C PF03836.10 KOG99582.1 - 9.1 5.9 33.5 0.81 9.3 9.6 3.3 2 1 1 3 3 3 0 RasGAP C-terminus Nrap PF03813.9 KOG99583.1 - 0 1226.6 2.8 0 1226.4 1.9 1.0 1 0 0 1 1 1 1 Nrap protein Nop PF01798.13 KOG99584.1 - 9.8e-45 151.5 0.0 1.7e-44 150.7 0.0 1.4 1 0 0 1 1 1 1 Putative snoRNA binding domain Prp31_C PF09785.4 KOG99584.1 - 3.9e-31 108.0 1.6 8.1e-31 107.0 1.1 1.5 1 0 0 1 1 1 1 Prp31 C terminal domain NOSIC PF08060.8 KOG99584.1 - 2.3e-10 40.0 0.1 5.2e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 NOSIC (NUC001) domain Pkinase PF00069.20 KOG99585.1 - 2.6e-54 184.1 0.1 2.9e-53 180.6 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99585.1 - 7.1e-28 97.3 0.2 2.1e-19 69.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.19 KOG99585.1 - 8.1e-06 26.2 3.8 6.2e-05 23.4 0.6 2.7 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 KOG99585.1 - 0.0013 17.7 0.0 0.015 14.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOG99585.1 - 0.019 14.0 0.0 0.037 13.0 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG99585.1 - 0.062 13.0 0.7 0.34 10.5 0.3 2.5 2 1 0 2 2 2 0 Phosphotransferase enzyme family CwfJ_C_1 PF04677.10 KOG99586.1 - 2.4e-37 127.2 0.2 5.8e-37 126.0 0.2 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 KOG99586.1 - 1.1e-21 77.1 0.6 2.9e-21 75.7 0.4 1.8 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 tRNA-synt_1 PF00133.17 KOG99587.1 - 5e-233 774.4 0.0 2.6e-232 772.1 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 KOG99587.1 - 5.1e-31 107.4 2.4 1.5e-30 105.9 1.7 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 KOG99587.1 - 2.4e-18 66.0 0.3 6.3e-10 38.2 0.0 4.5 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 KOG99587.1 - 8.1e-08 31.7 0.1 1.2e-06 27.9 0.0 3.7 3 1 1 4 4 4 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.4 KOG99587.1 - 0.0013 18.7 6.3 0.0013 18.7 4.4 2.9 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1e PF01406.14 KOG99587.1 - 0.011 14.8 4.4 0.43 9.6 0.0 3.3 4 1 0 4 4 4 0 tRNA synthetases class I (C) catalytic domain RNase_PH PF01138.16 KOG99588.1 - 7.7e-19 68.3 0.0 1.2e-18 67.7 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 KOG99588.1 - 1.4e-07 31.3 1.1 3.5e-07 30.0 0.1 2.0 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Mito_carr PF00153.22 KOG99589.1 - 3e-61 203.1 3.4 2.4e-21 75.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Herpes_IE1 PF07340.6 KOG99589.1 - 0.088 11.2 0.0 0.13 10.7 0.0 1.2 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein PH PF00169.24 KOG99590.1 - 5.3e-35 119.7 0.4 1.8e-34 118.0 0.2 2.0 1 0 0 1 1 1 1 PH domain Peptidase_C50 PF03568.12 KOG99591.1 - 2.4e-137 457.6 0.5 5.8e-137 456.4 0.3 1.7 1 0 0 1 1 1 1 Peptidase family C50 Telomere_reg-2 PF10193.4 KOG99592.1 - 3.4e-27 94.9 1.5 2.2e-26 92.3 0.2 2.5 2 0 0 2 2 2 1 Telomere length regulation protein Ada3 PF10198.4 KOG99592.1 - 0.00011 21.9 0.5 0.0053 16.5 0.3 2.8 2 1 0 2 2 2 1 Histone acetyltransferases subunit 3 RabGAP-TBC PF00566.13 KOG99593.1 - 2.1e-51 174.4 0.5 2.1e-51 174.4 0.4 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GRAM PF02893.15 KOG99593.1 - 1.6e-15 56.3 0.0 4.5e-15 54.9 0.0 1.9 1 0 0 1 1 1 1 GRAM domain EF-hand_6 PF13405.1 KOG99593.1 - 4.4e-06 26.1 0.9 0.00047 19.8 0.0 3.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KOG99593.1 - 1e-05 25.5 1.2 1e-05 25.5 0.9 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.27 KOG99593.1 - 0.0016 17.6 0.1 0.0068 15.6 0.0 2.2 2 0 0 2 2 2 1 EF hand Rhomboid PF01694.17 KOG99594.1 - 1.9e-30 105.8 16.2 1.9e-30 105.8 11.2 1.8 2 0 0 2 2 2 1 Rhomboid family Pescadillo_N PF06732.6 KOG99596.1 - 1.1e-127 425.0 1.6 1.1e-127 425.0 1.1 3.0 3 0 0 3 3 3 1 Pescadillo N-terminus BRCT PF00533.21 KOG99596.1 - 2.1e-11 43.7 0.0 1.5e-10 41.0 0.0 2.4 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain Med18 PF09637.5 KOG99597.1 - 4.9e-78 262.1 1.2 9.6e-78 261.1 0.8 1.4 1 1 0 1 1 1 1 Med18 protein VMA21 PF09446.5 KOG99598.1 - 1.2e-16 60.3 9.7 1.5e-16 60.0 6.8 1.2 1 0 0 1 1 1 1 VMA21-like domain DAD PF02109.11 KOG99598.1 - 0.013 15.5 0.6 0.015 15.3 0.4 1.1 1 0 0 1 1 1 0 DAD family MscS_TM PF12794.2 KOG99598.1 - 0.03 12.9 0.3 0.03 12.9 0.2 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 PAP2_C PF14360.1 KOG99598.1 - 0.23 11.7 1.5 0.36 11.1 1.0 1.4 1 1 0 1 1 1 0 PAP2 superfamily C-terminal DUF21 PF01595.15 KOG99598.1 - 0.34 10.1 2.5 0.38 10.0 1.7 1.0 1 0 0 1 1 1 0 Domain of unknown function DUF21 ATP-synt_S1 PF05827.7 KOG99599.1 - 0.00033 20.0 0.0 0.00061 19.2 0.0 1.4 1 1 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) DUF4064 PF13273.1 KOG99599.1 - 0.065 13.3 4.9 3.3 7.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Cyclin_N PF00134.18 KOG99600.1 - 1.6e-40 137.5 0.2 7.7e-40 135.3 0.1 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 KOG99600.1 - 1.3e-28 99.3 0.1 4.4e-28 97.5 0.0 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_N PF00134.18 KOG99601.1 - 3e-42 143.1 2.3 1.1e-38 131.6 1.0 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.14 KOG99601.1 - 1.1e-20 73.6 0.0 2.3e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Abhydrolase_1 PF00561.15 KOG99602.1 - 1e-26 93.9 0.1 1.3e-26 93.5 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOG99602.1 - 1.7e-19 70.5 0.0 2.7e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOG99602.1 - 8.4e-08 32.0 0.0 2.3e-07 30.6 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.8 KOG99602.1 - 0.00036 20.1 0.0 0.00071 19.2 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase DUF2305 PF10230.4 KOG99602.1 - 0.022 14.1 0.1 0.066 12.6 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2305) Acetyltransf_7 PF13508.1 KOG99603.1 - 1.7e-05 24.8 0.0 4.3e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TLD PF07534.11 KOG99603.1 - 0.016 15.2 0.1 0.04 13.8 0.0 1.7 1 0 0 1 1 1 0 TLD Acetyltransf_1 PF00583.19 KOG99603.1 - 0.031 14.2 0.0 0.34 10.9 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.1 KOG99603.1 - 0.075 12.8 0.0 0.43 10.4 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain SURF1 PF02104.10 KOG99604.1 - 3.6e-65 219.7 0.0 7.6e-65 218.7 0.0 1.5 2 0 0 2 2 2 1 SURF1 family DASH_Dam1 PF08653.5 KOG99605.1 - 1.5e-26 91.9 1.0 3.1e-26 90.8 0.1 1.9 2 0 0 2 2 2 1 DASH complex subunit Dam1 Suppressor_APC PF11414.3 KOG99605.1 - 0.095 12.4 0.9 0.23 11.2 0.4 1.8 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein SH2_2 PF14633.1 KOG99606.1 - 4.8e-110 365.8 4.2 1.5e-109 364.2 2.0 2.6 2 0 0 2 2 2 1 SH2 domain YqgF PF14639.1 KOG99606.1 - 5.3e-69 230.5 0.0 1.7e-68 228.9 0.0 1.9 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 DLD PF14878.1 KOG99606.1 - 2.9e-50 169.1 4.2 2.9e-50 169.1 2.9 4.1 3 0 0 3 3 3 1 Death-like domain of SPT6 HHH_7 PF14635.1 KOG99606.1 - 1.3e-47 160.1 0.2 4.4e-47 158.4 0.1 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.1 KOG99606.1 - 3.2e-44 149.7 3.0 3.2e-44 149.7 2.1 3.4 3 0 0 3 3 3 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.1 KOG99606.1 - 5.7e-23 80.8 22.0 5.7e-23 80.8 15.2 5.5 5 1 1 6 6 6 1 Acidic N-terminal SPT6 SH2 PF00017.19 KOG99606.1 - 6.1e-14 51.5 0.2 2.5e-13 49.6 0.1 2.2 2 0 0 2 2 2 1 SH2 domain B2-adapt-app_C PF09066.5 KOG99606.1 - 0.0012 18.6 0.3 0.014 15.2 0.0 2.6 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain WD40 PF00400.27 KOG99607.1 - 0.0018 18.0 0.5 1.2 9.1 0.1 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat LisH PF08513.6 KOG99607.1 - 0.0084 15.8 0.0 0.02 14.6 0.0 1.7 1 0 0 1 1 1 1 LisH CNH PF00780.17 KOG99607.1 - 0.022 14.2 0.0 0.12 11.7 0.0 2.1 2 0 0 2 2 2 0 CNH domain DUF4165 PF13752.1 KOG99607.1 - 0.11 12.2 0.1 0.46 10.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4165) Ribosom_S12_S23 PF00164.20 KOG99608.1 - 7.9e-41 138.3 0.5 9.3e-41 138.0 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Nup54 PF13874.1 KOG99609.1 - 8.6e-41 138.9 4.9 8.6e-41 138.9 3.4 2.4 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.1 KOG99609.1 - 1e-16 61.1 129.6 8e-08 32.5 30.6 4.3 2 1 2 4 4 4 3 Nucleoporin FG repeat region TFIIA PF03153.8 KOG99609.1 - 0.3 10.9 24.3 0.016 15.1 12.9 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit COG2 PF06148.6 KOG99610.1 - 1e-09 38.3 5.6 1.2e-09 38.1 2.6 2.0 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Syntaxin_2 PF14523.1 KOG99610.1 - 0.0018 18.2 5.7 0.69 9.9 0.0 2.8 2 1 0 2 2 2 2 Syntaxin-like protein zf-C3HC PF07967.8 KOG99610.1 - 0.021 14.5 0.5 0.054 13.2 0.1 1.9 2 1 1 3 3 3 0 C3HC zinc finger-like RPA_interact_M PF14767.1 KOG99610.1 - 0.13 13.0 9.3 9 7.1 0.0 3.5 2 2 2 4 4 4 0 Replication protein A interacting middle Rsd_AlgQ PF04353.8 KOG99610.1 - 0.17 11.6 5.4 0.23 11.1 1.9 2.4 1 1 2 3 3 3 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ DUF948 PF06103.6 KOG99610.1 - 0.32 10.8 3.0 0.6 10.0 1.1 2.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) IncA PF04156.9 KOG99610.1 - 2.5 7.6 8.2 12 5.4 5.7 2.1 1 1 0 1 1 1 0 IncA protein Ammonium_transp PF00909.16 KOG99611.1 - 2.5e-127 424.6 22.8 2.9e-127 424.4 15.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Bacteriocin_IIc PF10439.4 KOG99611.1 - 0.63 10.2 6.9 9.9 6.3 1.1 3.1 3 0 0 3 3 3 0 Bacteriocin class II with double-glycine leader peptide ABC2_membrane_2 PF12679.2 KOG99611.1 - 1.4 7.7 13.0 0.018 13.8 3.1 2.0 2 1 0 2 2 2 0 ABC-2 family transporter protein Metallophos PF00149.23 KOG99613.1 - 3.4e-38 131.0 0.2 5.7e-38 130.3 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_11 PF13414.1 KOG99613.1 - 6.4e-21 73.7 1.0 4.1e-17 61.5 0.1 2.5 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOG99613.1 - 5.5e-15 53.9 1.2 2.8e-05 23.7 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOG99613.1 - 1.6e-13 49.6 1.8 3.3e-06 26.4 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat PPP5 PF08321.7 KOG99613.1 - 9.5e-13 47.9 0.1 9.9e-10 38.3 0.0 3.2 2 1 0 2 2 2 1 PPP5 TPR repeat region TPR_19 PF14559.1 KOG99613.1 - 3.9e-05 23.8 0.9 0.00053 20.2 0.2 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOG99613.1 - 0.00032 20.4 0.0 0.0011 18.7 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOG99613.1 - 0.00042 20.2 0.4 0.34 11.2 0.0 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOG99613.1 - 0.00056 19.7 0.3 0.03 14.1 0.0 2.9 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.1 KOG99613.1 - 0.00089 19.8 0.0 0.0068 17.0 0.0 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOG99613.1 - 0.007 16.2 0.1 0.12 12.2 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOG99613.1 - 0.02 15.4 0.0 0.54 11.0 0.0 2.9 2 1 1 3 3 2 0 Tetratricopeptide repeat NBP1 PF08537.5 KOG99613.1 - 0.086 12.0 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 Asn_synthase PF00733.16 KOG99614.1 - 1e-69 234.8 0.0 1.4e-69 234.4 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 KOG99614.1 - 4.7e-34 116.8 0.0 7.7e-34 116.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 KOG99614.1 - 1.6e-27 96.1 0.0 6.4e-27 94.1 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.3 KOG99614.1 - 1e-08 34.7 0.0 1.8e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein GATase_2 PF00310.16 KOG99614.1 - 8.7e-06 24.6 0.0 0.16 10.6 0.0 3.0 1 1 2 3 3 3 2 Glutamine amidotransferases class-II NAD_synthase PF02540.12 KOG99614.1 - 0.0042 16.0 0.0 0.0075 15.1 0.0 1.4 1 0 0 1 1 1 1 NAD synthase Sulfate_transp PF00916.15 KOG99615.1 - 5.1e-58 196.2 9.3 1.3e-57 194.9 6.5 1.7 1 0 0 1 1 1 1 Sulfate transporter family STAS PF01740.16 KOG99615.1 - 1.6e-16 59.7 1.3 3.4e-16 58.7 0.9 1.6 1 0 0 1 1 1 1 STAS domain cNMP_binding PF00027.24 KOG99615.1 - 0.00038 20.2 0.0 0.00077 19.2 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain NRDE PF05742.7 KOG99617.1 - 5.7e-87 291.4 0.0 6.4e-87 291.3 0.0 1.0 1 0 0 1 1 1 1 NRDE protein Utp8 PF10395.4 KOG99618.1 - 2.9e-231 769.4 25.2 3.3e-231 769.2 17.5 1.0 1 0 0 1 1 1 1 Utp8 family SYF2 PF08231.7 KOG99619.1 - 3.6e-11 43.4 16.4 3.6e-11 43.4 11.4 1.5 2 0 0 2 2 2 1 SYF2 splicing factor Phage_tail_2 PF06199.6 KOG99619.1 - 0.078 13.0 2.3 0.07 13.1 0.6 1.6 1 1 0 1 1 1 0 Phage major tail protein 2 MtrE PF04206.7 KOG99620.1 - 0.35 9.8 0.5 0.54 9.2 0.4 1.2 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit E MARVEL PF01284.18 KOG99621.1 - 4.3e-27 94.6 14.1 5.4e-27 94.3 9.8 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF1218 PF06749.7 KOG99621.1 - 0.029 14.8 1.5 0.029 14.8 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) DUF3844 PF12955.2 KOG99621.1 - 0.034 14.2 0.3 0.034 14.2 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3844) Band_7 PF01145.20 KOG99622.1 - 1.4e-26 93.5 2.1 2.2e-26 92.8 1.4 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 KOG99622.1 - 0.011 15.3 0.1 0.018 14.6 0.1 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family UQ_con PF00179.21 KOG99623.1 - 6.6e-36 122.8 0.0 7.5e-36 122.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.6 KOG99623.1 - 0.0033 16.8 0.0 0.0049 16.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.17 KOG99623.1 - 0.08 12.8 0.1 0.17 11.8 0.1 1.4 1 1 0 1 1 1 0 RWD domain PV_NSP1 PF12433.3 KOG99624.1 - 0.05 13.6 1.4 1.2 9.2 0.1 3.2 3 0 0 3 3 3 0 Parvovirus non-structural protein 1 Proteasome PF00227.21 KOG99625.1 - 5.2e-58 195.4 0.6 6.4e-58 195.1 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KOG99625.1 - 2.1e-13 49.2 0.2 4.2e-13 48.3 0.2 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Lipocalin_6 PF13944.1 KOG99625.1 - 0.015 15.4 1.1 4.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Lipocalin-like domain SH3_1 PF00018.23 KOG99626.1 - 1.5e-15 56.3 0.0 3e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 KOG99626.1 - 1.4e-12 46.8 0.0 2.1e-11 43.1 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.1 KOG99626.1 - 1.7e-11 43.5 0.0 2.9e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain PAT1 PF09770.4 KOG99626.1 - 0.12 10.5 23.1 0.15 10.3 16.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MFS_1 PF07690.11 KOG99627.1 - 2.2e-32 112.1 32.6 2.2e-32 112.1 22.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOG99627.1 - 8.9e-13 47.6 22.0 2.3e-12 46.2 15.2 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter Nucleo_P87 PF07267.6 KOG99627.1 - 2.5 6.6 6.4 3.5 6.2 4.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TRI5 PF06330.6 KOG99628.1 - 0.14 10.7 0.0 0.19 10.3 0.0 1.1 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) GCR1_C PF12550.3 KOG99629.1 - 1.6e-17 63.0 0.1 3.7e-17 61.9 0.0 1.7 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes TAFH PF07531.9 KOG99629.1 - 0.15 11.7 3.3 3.2 7.4 0.3 2.5 2 0 0 2 2 2 0 NHR1 homology to TAF Spt5_N PF11942.3 KOG99629.1 - 3.8 8.2 18.6 0.12 13.0 5.2 2.7 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal DUF946 PF06101.6 KOG99630.1 - 4.9e-08 31.4 1.8 1.1e-07 30.2 0.5 1.8 2 0 0 2 2 2 1 Plant protein of unknown function (DUF946) DUF4407 PF14362.1 KOG99631.1 - 6.8 5.5 9.4 9.9 5.0 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SKN1 PF03935.10 KOG99632.1 - 4.4e-254 843.2 5.9 6e-254 842.7 4.1 1.2 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Thi4 PF01946.12 KOG99633.1 - 7.8e-105 349.0 0.1 9.3e-105 348.8 0.1 1.0 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 KOG99633.1 - 1.1e-08 34.3 0.4 2.2e-08 33.4 0.2 1.5 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 KOG99633.1 - 4.3e-06 26.6 0.1 1.5e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 KOG99633.1 - 5.5e-06 25.4 0.8 0.00018 20.5 0.3 2.2 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.7 KOG99633.1 - 2.9e-05 23.1 0.1 4.4e-05 22.5 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.1 KOG99633.1 - 0.00081 19.5 0.0 0.0015 18.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KOG99633.1 - 0.00097 18.9 0.0 0.0038 17.0 0.0 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_oxidored PF12831.2 KOG99633.1 - 0.0012 17.9 0.0 0.0017 17.4 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 KOG99633.1 - 0.0013 17.2 0.0 0.005 15.3 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.9 KOG99633.1 - 0.0017 18.3 0.3 0.0032 17.3 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 KOG99633.1 - 0.0099 14.7 0.1 0.043 12.6 0.0 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A Trp_halogenase PF04820.9 KOG99633.1 - 0.093 11.3 0.1 0.13 10.8 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase K_oxygenase PF13434.1 KOG99633.1 - 0.095 11.6 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.14 KOG99633.1 - 0.1 11.6 0.1 0.15 11.1 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain NUC153 PF08159.7 KOG99634.1 - 3.2e-12 45.8 5.8 7.3e-12 44.6 4.0 1.7 1 0 0 1 1 1 1 NUC153 domain Ecl1 PF12855.2 KOG99635.1 - 1.5e-19 68.9 4.0 3e-19 68.0 2.8 1.5 1 0 0 1 1 1 1 Life-span regulatory factor RPAP2_Rtr1 PF04181.8 KOG99635.1 - 0.12 12.5 2.7 0.21 11.6 1.9 1.4 1 0 0 1 1 1 0 Rtr1/RPAP2 family DUF1279 PF06916.8 KOG99637.1 - 7.2e-22 77.5 0.0 1.5e-21 76.4 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) HMG_box_2 PF09011.5 KOG99637.1 - 0.72 10.2 5.1 9.1 6.7 0.2 2.5 2 0 0 2 2 2 0 HMG-box domain Ribosomal_L24e PF01246.15 KOG99638.1 - 4.4e-33 112.9 0.4 4.4e-33 112.9 0.3 2.0 2 1 0 2 2 2 1 Ribosomal protein L24e DUF2838 PF10998.3 KOG99639.1 - 4.5e-44 148.8 17.5 4.5e-44 148.8 12.1 2.7 3 1 0 3 3 3 1 Protein of unknown function (DUF2838) PPR_2 PF13041.1 KOG99640.1 - 3.6e-13 49.2 1.1 3.1e-09 36.6 0.0 3.9 3 1 1 4 4 4 2 PPR repeat family PPR_3 PF13812.1 KOG99640.1 - 1e-07 31.6 0.8 0.019 15.2 0.0 5.6 7 0 0 7 7 7 2 Pentatricopeptide repeat domain PPR PF01535.15 KOG99640.1 - 1.2e-06 28.0 0.0 9.1e-05 22.1 0.0 3.6 3 0 0 3 3 3 1 PPR repeat Ras PF00071.17 KOG99641.1 - 2.1e-50 170.2 0.0 3.2e-50 169.6 0.0 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG99641.1 - 1.9e-17 63.8 0.5 5.2e-17 62.4 0.0 1.9 2 1 0 2 2 2 1 Miro-like protein Arf PF00025.16 KOG99641.1 - 9.9e-08 31.4 0.1 1.5e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KOG99641.1 - 3.4e-07 29.9 0.0 9.4e-07 28.4 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOG99641.1 - 0.0037 17.1 1.2 0.0061 16.5 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Neur_chan_memb PF02932.11 KOG99641.1 - 8.3 6.2 10.8 12 5.6 7.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PALP PF00291.20 KOG99643.1 - 1.2e-56 192.1 0.0 1.5e-56 191.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.23 KOG99643.1 - 8.9e-17 60.6 0.0 1.8e-11 43.6 0.1 2.6 2 0 0 2 2 2 2 CBS domain DUF2181 PF10223.4 KOG99643.1 - 0.062 12.6 0.1 0.1 11.9 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2181) GHMP_kinases_C PF08544.8 KOG99643.1 - 0.095 12.9 0.0 2.8 8.2 0.0 2.7 3 0 0 3 3 3 0 GHMP kinases C terminal CSTF2_hinge PF14327.1 KOG99644.1 - 9.4e-27 92.9 2.1 9.4e-27 92.9 1.4 2.7 3 0 0 3 3 3 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.17 KOG99644.1 - 0.019 14.5 0.0 0.11 12.1 0.0 2.3 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MarR PF01047.17 KOG99644.1 - 0.028 14.0 0.1 0.059 13.0 0.1 1.5 1 0 0 1 1 1 0 MarR family CSTF_C PF14304.1 KOG99644.1 - 0.03 13.5 8.0 0.099 11.9 2.0 3.2 3 0 0 3 3 3 0 Transcription termination and cleavage factor C-terminal PEMT PF04191.8 KOG99645.1 - 2.9e-53 178.4 9.1 7.4e-32 109.6 1.2 4.1 4 1 1 5 5 5 2 Phospholipid methyltransferase RNase_PH PF01138.16 KOG99646.1 - 7.5e-18 65.1 0.0 1.1e-17 64.5 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RRM_1 PF00076.17 KOG99647.1 - 1.2e-43 146.6 0.0 4.9e-21 74.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG99647.1 - 1.2e-30 105.3 0.0 5.7e-15 55.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG99647.1 - 7.5e-21 73.7 0.0 2.8e-10 39.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.4 KOG99647.1 - 0.0046 15.4 34.5 0.0052 15.3 23.9 1.2 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Daxx PF03344.10 KOG99647.1 - 0.0056 15.2 31.5 0.0077 14.7 21.8 1.4 1 0 0 1 1 1 1 Daxx Family Mitofilin PF09731.4 KOG99647.1 - 0.0082 14.8 24.1 0.011 14.4 16.7 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein BUD22 PF09073.5 KOG99647.1 - 0.014 14.5 55.0 0.02 13.9 38.2 1.2 1 0 0 1 1 1 0 BUD22 Nup35_RRM_2 PF14605.1 KOG99647.1 - 0.016 15.0 0.0 0.41 10.4 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 KOG99647.1 - 0.023 14.4 0.0 0.18 11.5 0.0 2.5 2 0 0 2 2 2 0 Limkain b1 SOBP PF15279.1 KOG99647.1 - 0.11 12.9 11.5 0.14 12.5 8.0 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein DUF2046 PF09755.4 KOG99648.1 - 0.0021 17.0 0.0 0.0029 16.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) MerR_2 PF13591.1 KOG99648.1 - 0.016 14.8 0.8 0.031 13.8 0.5 1.5 1 0 0 1 1 1 0 MerR HTH family regulatory protein NYD-SP28_assoc PF14775.1 KOG99648.1 - 0.052 13.2 0.6 0.12 12.1 0.4 1.6 1 0 0 1 1 1 0 Sperm tail C-terminal domain HALZ PF02183.13 KOG99648.1 - 0.13 11.9 0.6 0.3 10.8 0.4 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF3545 PF12065.3 KOG99648.1 - 0.5 10.1 3.1 1.2 8.9 1.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3545) MIF4G PF02854.14 KOG99650.1 - 1.5e-50 171.5 0.1 2.5e-50 170.8 0.0 1.4 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.3 KOG99650.1 - 8.1e-27 92.9 1.1 2.6e-26 91.2 0.0 2.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 4G1 Gtr1_RagA PF04670.7 KOG99651.1 - 5.3e-69 231.8 1.4 6.8e-69 231.5 0.9 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_14 PF13173.1 KOG99651.1 - 0.00055 19.8 0.0 0.0013 18.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 KOG99651.1 - 0.0067 15.3 0.0 0.018 13.9 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Arch_ATPase PF01637.13 KOG99651.1 - 0.015 14.9 0.0 0.038 13.6 0.0 1.8 1 1 0 1 1 1 0 Archaeal ATPase SRPRB PF09439.5 KOG99651.1 - 0.029 13.5 0.1 0.079 12.1 0.0 1.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Arf PF00025.16 KOG99651.1 - 0.063 12.5 0.1 0.21 10.8 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family Miro PF08477.8 KOG99651.1 - 0.066 13.7 0.1 0.21 12.0 0.0 1.8 2 0 0 2 2 2 0 Miro-like protein Bot1p PF12298.3 KOG99652.1 - 7.3e-60 201.8 0.0 1e-59 201.3 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein Trs65 PF12735.2 KOG99653.1 - 8.5e-53 179.6 9.9 8.5e-53 179.6 6.8 1.6 2 0 0 2 2 2 1 TRAPP trafficking subunit Trs65 Clathrin_lg_ch PF01086.12 KOG99654.1 - 1.4e-58 198.4 27.1 1.6e-58 198.3 18.8 1.0 1 0 0 1 1 1 1 Clathrin light chain DUF4521 PF15021.1 KOG99654.1 - 0.0049 16.4 3.6 0.0068 16.0 2.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4521) TraY PF05509.6 KOG99654.1 - 0.19 11.5 1.4 8.4 6.2 0.1 2.9 2 0 0 2 2 2 0 TraY domain DUF2201_N PF13203.1 KOG99654.1 - 0.57 9.2 7.6 0.71 8.9 5.3 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF4407 PF14362.1 KOG99654.1 - 6 5.7 9.7 8.9 5.1 6.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) PseudoU_synth_2 PF00849.17 KOG99656.1 - 1.1e-25 90.3 0.0 1.8e-25 89.6 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase SAPS PF04499.10 KOG99657.1 - 0.72 8.4 10.4 0.76 8.3 7.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF1764 PF08576.5 KOG99657.1 - 3.5 8.4 14.0 4.2 8.2 9.7 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) GRIM-19 PF06212.7 KOG99657.1 - 5.7 6.6 7.6 10 5.8 0.2 2.0 1 1 1 2 2 2 0 GRIM-19 protein BTV_NS2 PF04514.7 KOG99657.1 - 8.9 5.0 13.2 10 4.8 9.2 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 PS_Dcarbxylase PF02666.10 KOG99658.1 - 1.4e-52 177.9 0.0 2.3e-52 177.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.25 KOG99658.1 - 9.1e-18 63.8 3.1 4.2e-10 39.3 0.1 3.5 3 0 0 3 3 3 2 C2 domain tRNA-synt_1g PF09334.6 KOG99659.1 - 5.1e-104 348.0 1.1 2e-103 346.1 0.8 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 KOG99659.1 - 1.2e-21 76.3 1.7 3.8e-11 41.7 0.0 4.2 2 1 1 4 4 4 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 KOG99659.1 - 7e-08 31.9 0.0 7.6e-05 21.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.13 KOG99659.1 - 0.009 14.7 0.0 0.015 14.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (K) Fascin PF06268.8 KOG99659.1 - 0.064 13.3 0.0 0.2 11.7 0.0 1.8 1 0 0 1 1 1 0 Fascin domain Yip1 PF04893.12 KOG99660.1 - 2e-12 46.9 14.7 2.8e-12 46.4 10.2 1.3 1 0 0 1 1 1 1 Yip1 domain MMR_HSR1 PF01926.18 KOG99661.1 - 7.5e-20 71.0 0.7 1.9e-19 69.7 0.1 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.16 KOG99661.1 - 1.5e-18 66.3 0.0 4e-18 64.9 0.0 1.8 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 KOG99661.1 - 1.8e-13 50.0 0.0 3e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 KOG99661.1 - 6.6e-05 22.7 0.6 0.028 14.2 0.0 2.4 1 1 1 2 2 2 2 Dynamin family Miro PF08477.8 KOG99661.1 - 0.00025 21.5 0.1 0.001 19.5 0.0 2.0 2 0 0 2 2 2 1 Miro-like protein AIG1 PF04548.11 KOG99661.1 - 0.00096 18.3 0.1 0.0017 17.5 0.0 1.3 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.5 KOG99661.1 - 0.0073 15.5 0.7 0.035 13.3 0.4 2.1 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit MCM PF00493.18 KOG99661.1 - 0.014 14.2 0.0 0.031 13.0 0.0 1.5 1 0 0 1 1 1 0 MCM2/3/5 family GTP_EFTU PF00009.22 KOG99661.1 - 0.017 14.6 2.8 8 5.8 0.1 3.4 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain Ras PF00071.17 KOG99661.1 - 0.034 13.5 0.5 0.94 8.8 0.0 2.3 2 0 0 2 2 2 0 Ras family CBP4 PF07960.6 KOG99662.1 - 7.6e-53 177.5 2.1 8.6e-53 177.3 1.5 1.0 1 0 0 1 1 1 1 CBP4 DUF3552 PF12072.3 KOG99662.1 - 0.0031 16.7 0.0 0.0053 15.9 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3552) DUF4056 PF13265.1 KOG99662.1 - 0.1 11.5 1.3 0.14 11.1 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4056) Synaptobrevin PF00957.16 KOG99662.1 - 0.45 10.1 2.1 2.5 7.7 0.3 2.3 2 0 0 2 2 2 0 Synaptobrevin Atg14 PF10186.4 KOG99662.1 - 0.91 8.4 5.4 1.1 8.0 3.7 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 LAMTOR PF15454.1 KOG99662.1 - 1.2 9.4 5.4 0.43 10.8 0.6 2.1 1 1 1 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Mt_ATP-synt_B PF05405.9 KOG99662.1 - 2.1 7.7 5.8 5.4 6.4 0.4 2.1 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) SE PF08491.5 KOG99663.1 - 8.1e-124 411.8 0.0 1.1e-123 411.5 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.14 KOG99663.1 - 5.8e-13 48.6 0.0 8.3e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 KOG99663.1 - 2.1e-07 30.1 0.1 3.5e-05 22.8 0.2 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOG99663.1 - 0.0017 18.7 0.1 0.0052 17.1 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 KOG99663.1 - 0.0031 17.4 0.0 0.0065 16.3 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KOG99663.1 - 0.0047 16.9 0.1 0.01 15.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 KOG99663.1 - 0.0068 15.2 0.7 0.015 14.1 0.5 1.5 2 0 0 2 2 2 1 FAD binding domain 3HCDH_N PF02737.13 KOG99663.1 - 0.0082 15.8 0.2 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.12 KOG99663.1 - 0.0088 15.1 0.1 0.019 14.1 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Shikimate_DH PF01488.15 KOG99663.1 - 0.016 15.3 0.1 0.028 14.5 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GDI PF00996.13 KOG99663.1 - 0.024 12.9 0.0 0.039 12.2 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor HI0933_like PF03486.9 KOG99663.1 - 0.096 11.1 0.6 0.55 8.6 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein ApbA PF02558.11 KOG99663.1 - 0.12 11.8 0.1 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.2 KOG99663.1 - 0.15 11.1 0.6 0.29 10.1 0.4 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.9 KOG99663.1 - 0.15 11.4 0.4 0.35 10.2 0.1 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Lycopene_cycl PF05834.7 KOG99663.1 - 3 6.6 3.8 3.7 6.3 0.2 2.5 3 1 1 4 4 4 0 Lycopene cyclase protein AATase PF07247.7 KOG99664.1 - 6.1e-171 569.1 0.8 6.9e-171 568.9 0.5 1.0 1 0 0 1 1 1 1 Alcohol acetyltransferase Tri3 PF07428.6 KOG99664.1 - 0.043 12.5 0.0 0.067 11.9 0.0 1.2 1 0 0 1 1 1 0 15-O-acetyltransferase Tri3 LsmAD PF06741.8 KOG99665.1 - 3.6e-29 100.6 3.0 5.7e-29 100.0 0.1 2.7 2 0 0 2 2 2 1 LsmAD domain SM-ATX PF14438.1 KOG99665.1 - 2.4e-17 62.6 0.3 6.1e-17 61.3 0.2 1.8 1 0 0 1 1 1 1 Ataxin 2 SM domain SOG2 PF10428.4 KOG99665.1 - 7.1 5.1 21.1 4.4 5.8 12.4 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein CENP-Q PF13094.1 KOG99666.1 - 0.0031 17.5 7.8 0.0031 17.5 5.4 3.5 1 1 2 3 3 3 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF2404 PF10296.4 KOG99666.1 - 0.026 14.6 0.2 0.074 13.1 0.1 1.9 1 0 0 1 1 1 0 Putative integral membrane protein conserved region (DUF2404) Ribonuc_red_sm PF00268.16 KOG99667.1 - 3.2e-77 259.2 4.4 4.3e-77 258.8 3.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain zf-Tim10_DDP PF02953.10 KOG99669.1 - 9.5e-19 66.4 0.7 1.4e-18 65.9 0.5 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF3398 PF11878.3 KOG99669.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3398) UCR_UQCRX_QCR9 PF05365.7 KOG99670.1 - 8.4e-28 95.7 4.8 9.4e-28 95.6 3.3 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like DUF2976 PF11190.3 KOG99670.1 - 0.0033 16.9 0.1 0.0039 16.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2976) zf-UBR PF02207.15 KOG99671.1 - 6.7e-15 54.5 20.5 6.7e-15 54.5 14.2 2.7 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.12 KOG99671.1 - 1.3e-07 31.2 0.0 2.9e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS tRNA-synt_1b PF00579.20 KOG99672.1 - 5e-77 258.8 0.0 6.3e-77 258.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TFIIF_alpha PF05793.7 KOG99673.1 - 8.5e-10 37.6 0.5 8.5e-10 37.6 0.3 3.0 3 1 1 4 4 4 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF383 PF04063.9 KOG99674.1 - 8e-71 237.5 0.9 1.8e-70 236.3 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.8 KOG99674.1 - 1.8e-25 88.2 0.1 5.4e-25 86.7 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF384) Med8 PF10232.4 KOG99674.1 - 0.062 12.8 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 HEAT PF02985.17 KOG99674.1 - 0.12 12.5 0.0 0.94 9.7 0.0 2.7 1 0 0 1 1 1 0 HEAT repeat NOA36 PF06524.7 KOG99674.1 - 1.3 8.1 4.3 1.9 7.6 3.0 1.2 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.4 KOG99674.1 - 3.8 6.1 12.8 5.1 5.7 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nucleoplasmin PF03066.10 KOG99674.1 - 4 6.9 11.9 7.9 5.9 8.2 1.5 1 0 0 1 1 1 0 Nucleoplasmin Mad3_BUB1_I PF08311.7 KOG99675.1 - 5.3e-37 126.4 1.1 1e-36 125.4 0.7 1.5 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.6 KOG99675.1 - 4.2e-23 81.0 0.5 1.3e-22 79.4 0.1 2.0 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase PF00069.20 KOG99675.1 - 1.3e-16 60.5 0.0 2.5e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99675.1 - 0.0012 17.9 0.0 0.0024 17.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Glyco_hydro_16 PF00722.16 KOG99676.1 - 1.6e-47 161.2 3.1 1.6e-47 161.2 2.2 2.7 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 DUF605 PF04652.11 KOG99676.1 - 0.0023 17.4 31.6 0.0034 16.8 21.9 1.2 1 0 0 1 1 1 1 Vta1 like AA_permease PF00324.16 KOG99677.1 - 1.5e-137 458.8 32.6 1.7e-137 458.6 22.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG99677.1 - 1.5e-37 129.2 35.7 1.8e-37 128.8 24.7 1.0 1 0 0 1 1 1 1 Amino acid permease Gp_dh_C PF02800.15 KOG99678.1 - 3.4e-74 247.5 0.1 5.2e-74 246.9 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 KOG99678.1 - 1.2e-59 200.6 0.7 7e-59 198.1 0.1 2.0 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 KOG99678.1 - 0.01 15.7 1.7 0.015 15.2 0.3 2.1 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.14 KOG99678.1 - 0.073 12.2 0.1 0.23 10.5 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Biotin_lipoyl PF00364.17 KOG99679.1 - 1.6e-17 62.9 0.1 2.6e-17 62.2 0.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_3 PF13437.1 KOG99679.1 - 0.0026 18.0 0.5 0.81 10.0 0.0 2.7 1 1 1 2 2 2 2 HlyD family secretion protein E3_binding PF02817.12 KOG99679.1 - 0.0064 16.0 0.0 0.017 14.7 0.0 1.7 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.1 KOG99679.1 - 0.033 13.8 1.2 0.13 11.9 0.0 2.5 3 0 0 3 3 3 0 Biotin-lipoyl like FGGY_N PF00370.16 KOG99680.1 - 2.3e-27 95.9 0.0 7.7e-17 61.4 0.0 2.4 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.11 KOG99680.1 - 1.4e-16 60.6 0.0 1.2e-14 54.4 0.0 2.8 3 1 0 3 3 3 2 FGGY family of carbohydrate kinases, C-terminal domain RNase_PH PF01138.16 KOG99681.1 - 8e-26 90.9 0.0 1.1e-25 90.4 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 KOG99681.1 - 1.8e-06 27.7 0.3 5.2e-06 26.3 0.1 1.9 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 DUF3533 PF12051.3 KOG99683.1 - 4.1e-138 460.2 19.1 4.9e-138 460.0 13.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) PDR_CDR PF06422.7 KOG99683.1 - 0.046 13.3 0.0 0.14 11.8 0.0 1.8 1 0 0 1 1 1 0 CDR ABC transporter TPR_2 PF07719.12 KOG99684.1 - 0.2 11.6 3.8 4.6 7.3 0.0 4.7 6 1 0 6 6 6 0 Tetratricopeptide repeat PMT PF02366.13 KOG99685.1 - 3.7e-88 295.0 22.2 3.7e-88 295.0 15.4 2.1 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 KOG99685.1 - 5.8e-25 87.9 0.1 9.2e-25 87.2 0.1 1.3 1 0 0 1 1 1 1 MIR domain WD40 PF00400.27 KOG99686.1 - 7.9e-61 199.9 19.4 3.4e-09 36.2 0.0 11.6 13 0 0 13 13 13 9 WD domain, G-beta repeat GST_C PF00043.20 KOG99687.1 - 9.2e-09 35.1 0.0 1.2e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 KOG99687.1 - 0.0043 17.1 0.0 0.014 15.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOG99687.1 - 0.077 12.9 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain CTP_transf_2 PF01467.21 KOG99688.1 - 1.1e-24 87.2 0.0 2.4e-24 86.1 0.0 1.6 1 0 0 1 1 1 1 Cytidylyltransferase RR_TM4-6 PF06459.7 KOG99688.1 - 6.5 6.5 17.5 1.8 8.3 4.5 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Rhodanese PF00581.15 KOG99689.1 - 2.1e-09 37.7 0.0 1.8e-08 34.6 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain FTHFS PF01268.14 KOG99690.1 - 1.3e-255 848.6 1.5 1.8e-255 848.2 1.1 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.14 KOG99690.1 - 3.2e-60 201.8 2.2 5e-60 201.2 0.1 2.2 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 KOG99690.1 - 1e-38 131.9 0.0 1.4e-37 128.3 0.0 2.4 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AAA_14 PF13173.1 KOG99691.1 - 0.0065 16.3 0.0 0.015 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOG99691.1 - 0.013 16.3 0.0 0.029 15.1 0.0 1.6 1 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 KOG99691.1 - 0.017 15.2 0.1 0.045 13.9 0.0 1.8 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.1 KOG99691.1 - 0.057 13.7 0.0 0.14 12.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 KOG99691.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Mvb12 PF09452.5 KOG99692.1 - 4.4e-43 145.3 0.3 5e-43 145.1 0.2 1.0 1 0 0 1 1 1 1 ESCRT-I subunit Mvb12 ETF PF01012.16 KOG99693.1 - 1.2e-33 116.1 0.0 1.6e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain HAD PF12710.2 KOG99694.1 - 2.3e-14 53.9 0.1 3.6e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOG99694.1 - 4.9e-12 46.7 0.1 1.1e-11 45.5 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KOG99694.1 - 1.2e-08 34.8 0.7 7.2e-06 25.7 0.0 3.0 1 1 2 3 3 3 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOG99694.1 - 5.2e-05 23.5 0.0 0.00011 22.4 0.0 1.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 KOG99694.1 - 5.5e-05 22.4 0.2 0.00013 21.2 0.2 1.6 1 1 0 1 1 1 1 Putative Phosphatase Thioredoxin PF00085.15 KOG99695.1 - 2.8e-32 110.4 0.1 3.9e-32 110.0 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 KOG99695.1 - 2.7e-09 37.1 0.2 3.5e-08 33.6 0.2 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOG99695.1 - 2.8e-07 30.5 0.0 7.2e-06 26.0 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.1 KOG99695.1 - 6.7e-07 28.9 0.0 8.9e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.16 KOG99695.1 - 5.1e-06 26.1 0.1 6.6e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family DIM1 PF02966.11 KOG99695.1 - 5.8e-05 22.6 0.0 8.1e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Mitosis protein DIM1 Redoxin PF08534.5 KOG99695.1 - 0.00016 21.2 0.0 0.0002 20.9 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.1 KOG99695.1 - 0.015 15.2 0.1 0.035 14.1 0.1 1.7 1 1 0 1 1 1 0 Thioredoxin-like TraF PF13728.1 KOG99695.1 - 0.02 14.3 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_6 PF13848.1 KOG99695.1 - 0.095 12.4 0.1 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain DUF3289 PF11692.3 KOG99695.1 - 0.1 11.8 0.0 0.23 10.6 0.0 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3289) MMR_HSR1_C PF08438.5 KOG99696.1 - 6.5e-31 106.7 0.0 1e-30 106.1 0.0 1.3 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 KOG99696.1 - 4e-18 65.4 0.0 8.2e-18 64.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOG99696.1 - 4.1e-06 26.1 0.1 1.7e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 KOG99696.1 - 0.012 15.1 0.4 3.3 7.1 0.0 2.5 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 KOG99696.1 - 0.018 14.8 0.1 0.078 12.8 0.0 2.1 2 0 0 2 2 2 0 Dynamin family AAA_10 PF12846.2 KOG99696.1 - 0.022 14.2 0.0 0.1 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA-like domain AAA_17 PF13207.1 KOG99696.1 - 0.075 13.8 0.4 0.64 10.8 0.0 2.5 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.13 KOG99696.1 - 0.084 12.3 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family ArgK PF03308.11 KOG99696.1 - 0.096 11.4 0.5 0.24 10.1 0.0 1.9 3 0 0 3 3 3 0 ArgK protein KTI12 PF08433.5 KOG99696.1 - 0.13 11.4 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ATP_bind_1 PF03029.12 KOG99696.1 - 0.19 11.2 0.3 9.4 5.6 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein zf-ZPR1 PF03367.8 KOG99697.1 - 2.1e-121 400.8 7.1 2.9e-60 202.0 1.6 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain AATase PF07247.7 KOG99698.1 - 1.8e-64 218.1 4.3 2.2e-64 217.8 3.0 1.0 1 0 0 1 1 1 1 Alcohol acetyltransferase RTA1 PF04479.8 KOG99699.1 - 1.1e-85 286.7 14.2 1.1e-85 286.7 9.9 1.3 2 0 0 2 2 2 1 RTA1 like protein Ribosomal_S2 PF00318.15 KOG99700.1 - 8.1e-41 139.5 0.0 5.1e-21 74.8 0.0 2.6 2 1 1 3 3 3 2 Ribosomal protein S2 MRP-S33 PF08293.6 KOG99701.1 - 1.3e-31 108.4 0.1 1.3e-31 108.4 0.0 1.9 2 0 0 2 2 2 1 Mitochondrial ribosomal subunit S27 Gpi1 PF05024.10 KOG99702.1 - 2.3e-64 216.5 18.0 2.3e-64 216.5 12.5 1.9 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) Ion_trans PF00520.26 KOG99703.1 - 4.9e-98 326.2 84.5 1.1e-33 116.1 3.7 5.1 5 0 0 5 5 5 4 Ion transport protein FAM220 PF15487.1 KOG99703.1 - 0.058 12.7 5.6 0.097 12.0 3.9 1.2 1 0 0 1 1 1 0 FAM220 family CRM1_C PF08767.6 KOG99704.1 - 6.9e-129 429.3 6.9 6.9e-129 429.3 4.8 3.2 3 0 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.7 KOG99704.1 - 4.5e-38 130.4 6.9 4.5e-38 130.4 4.8 4.2 4 1 1 5 5 5 1 Exportin 1-like protein IBN_N PF03810.14 KOG99704.1 - 6.2e-15 54.8 0.6 3.7e-14 52.3 0.1 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain Ribosomal_L3 PF00297.17 KOG99705.1 - 4e-49 167.3 2.0 2.3e-47 161.5 1.4 2.1 1 1 0 1 1 1 1 Ribosomal protein L3 SKG6 PF08693.5 KOG99706.1 - 4.2e-13 48.3 6.6 8.7e-13 47.3 4.6 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.1 KOG99706.1 - 0.0029 17.3 0.0 0.011 15.4 0.0 2.0 1 0 0 1 1 1 1 TMEM154 protein family STE2 PF02116.10 KOG99706.1 - 0.02 13.9 0.1 0.03 13.3 0.1 1.2 1 0 0 1 1 1 0 Fungal pheromone mating factor STE2 GPCR RRM_1 PF00076.17 KOG99707.1 - 0.011 15.3 0.0 0.022 14.3 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EthD PF07110.6 KOG99707.1 - 0.073 14.0 0.0 0.77 10.7 0.0 2.5 2 1 0 2 2 2 0 EthD domain WD40 PF00400.27 KOG99708.1 - 0.0022 17.8 0.0 0.97 9.4 0.0 3.4 3 1 0 3 3 3 2 WD domain, G-beta repeat Viral_Rep PF02407.11 KOG99708.1 - 0.095 12.7 0.2 13 5.9 0.1 2.7 2 0 0 2 2 2 0 Putative viral replication protein DIE2_ALG10 PF04922.7 KOG99709.1 - 6.6e-142 473.0 36.4 6.6e-142 473.0 25.2 1.4 2 0 0 2 2 2 1 DIE2/ALG10 family SMI1_KNR4 PF09346.5 KOG99710.1 - 1.5e-34 118.8 4.1 3.6e-34 117.5 0.0 3.1 2 1 1 3 3 3 1 SMI1 / KNR4 family (SUKH-1) SLT_L PF14718.1 KOG99710.1 - 0.0026 17.5 0.6 0.026 14.2 0.0 2.8 3 0 0 3 3 3 1 Soluble lytic murein transglycosylase L domain CDC27 PF09507.5 KOG99710.1 - 1.7 7.8 35.7 2.7 7.1 24.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RIX1 PF08167.7 KOG99711.1 - 0.0053 16.4 0.1 0.0074 15.9 0.1 1.1 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis Spo12 PF05032.7 KOG99712.1 - 8.8e-18 63.6 3.2 8.8e-18 63.6 2.2 1.8 2 0 0 2 2 2 1 Spo12 family Band_7 PF01145.20 KOG99713.1 - 3.4e-22 79.2 1.5 3.4e-22 79.2 1.0 1.6 2 0 0 2 2 2 1 SPFH domain / Band 7 family Ank_2 PF12796.2 KOG99714.1 - 8e-33 112.6 0.0 4.9e-14 52.4 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOG99714.1 - 1.6e-29 100.1 0.0 2.1e-05 24.0 0.0 6.1 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.1 KOG99714.1 - 5.2e-25 87.3 2.0 1.7e-08 34.7 0.0 5.0 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOG99714.1 - 6.9e-24 81.5 0.0 7.6e-05 22.5 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 KOG99714.1 - 4.3e-21 74.4 0.4 0.00011 22.3 0.0 6.0 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOG99715.1 - 4.4e-35 119.8 0.2 1.2e-14 54.3 0.0 4.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 KOG99715.1 - 4.3e-26 89.3 3.6 2.6e-05 23.8 0.0 6.9 6 0 0 6 6 6 6 Ankyrin repeat SPX PF03105.14 KOG99715.1 - 7.2e-25 88.3 23.2 2.2e-14 53.9 5.2 3.1 2 1 1 3 3 3 2 SPX domain Ank_5 PF13857.1 KOG99715.1 - 2.7e-19 68.7 1.3 4.6e-05 23.5 0.0 5.8 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOG99715.1 - 1.6e-17 61.8 4.6 0.0041 17.2 0.0 7.9 7 1 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.1 KOG99715.1 - 3.4e-16 59.2 5.1 2.2e-05 24.8 0.0 5.3 4 1 1 5 5 5 3 Ankyrin repeats (many copies) FAD_binding_6 PF00970.19 KOG99716.1 - 5e-12 45.8 0.0 9e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Globin PF00042.17 KOG99716.1 - 2.4e-10 40.7 0.2 4.1e-09 36.7 0.0 2.3 2 0 0 2 2 2 1 Globin NAD_binding_1 PF00175.16 KOG99716.1 - 5.6e-05 23.6 0.0 0.00022 21.7 0.0 2.0 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Protoglobin PF11563.3 KOG99716.1 - 0.0054 16.4 0.3 0.02 14.5 0.2 2.0 1 1 0 1 1 1 1 Protoglobin ApoO PF09769.4 KOG99717.1 - 2.2e-40 137.9 0.1 3.8e-40 137.1 0.0 1.4 2 0 0 2 2 2 1 Apolipoprotein O KIP1 PF07765.7 KOG99719.1 - 0.046 13.5 0.5 0.23 11.3 0.1 2.3 2 0 0 2 2 2 0 KIP1-like protein Kelch_3 PF13415.1 KOG99720.1 - 4.1e-35 119.1 0.5 8.8e-08 32.1 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KOG99720.1 - 3.8e-31 106.5 4.3 9.8e-07 28.5 0.0 6.5 7 0 0 7 7 7 5 Kelch motif Kelch_4 PF13418.1 KOG99720.1 - 8.1e-30 102.3 12.3 1.4e-09 37.5 0.1 6.6 5 2 1 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.1 KOG99720.1 - 5.8e-27 92.7 9.1 2.4e-08 33.7 0.1 6.4 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.20 KOG99720.1 - 3.7e-25 87.2 0.9 1.9e-10 40.0 0.0 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 KOG99720.1 - 2.1e-17 62.1 4.7 0.039 13.7 0.0 6.6 6 0 0 6 6 6 5 Kelch motif RAG2 PF03089.9 KOG99720.1 - 0.0072 15.0 0.0 1.3 7.6 0.0 2.6 2 0 0 2 2 2 2 Recombination activating protein 2 PFK PF00365.15 KOG99722.1 - 4e-168 557.5 2.5 6.5e-125 415.7 1.0 2.3 2 0 0 2 2 2 2 Phosphofructokinase ANTH PF07651.11 KOG99723.1 - 5.6e-70 235.2 3.3 5.6e-70 235.2 2.3 2.5 3 0 0 3 3 3 1 ANTH domain ENTH PF01417.15 KOG99723.1 - 2.9e-09 36.8 0.3 2.9e-09 36.8 0.2 2.5 3 0 0 3 3 3 1 ENTH domain 2-oxoacid_dh PF00198.18 KOG99723.1 - 0.0032 16.7 0.0 0.007 15.6 0.0 1.6 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Utp14 PF04615.8 KOG99723.1 - 0.11 10.7 25.9 0.21 9.7 18.0 1.4 1 0 0 1 1 1 0 Utp14 protein DUF106 PF01956.11 KOG99723.1 - 4 6.9 17.2 0.78 9.2 6.5 2.6 2 0 0 2 2 2 0 Integral membrane protein DUF106 MPC PF03650.8 KOG99724.1 - 1.3e-52 176.8 0.3 1.5e-52 176.6 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) ATP-grasp_2 PF08442.5 KOG99725.1 - 1.9e-79 265.7 0.6 3.1e-79 265.0 0.4 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 KOG99725.1 - 3.7e-27 94.8 0.2 1.4e-26 92.9 0.1 2.0 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.1 KOG99725.1 - 3.1e-07 29.8 0.2 5.3e-07 29.0 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 KOG99725.1 - 0.00076 19.0 0.1 0.0022 17.5 0.0 1.7 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_4 PF13535.1 KOG99725.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain SDA1 PF05285.7 KOG99726.1 - 4.9e-92 308.6 31.9 4.9e-92 308.6 22.1 1.9 2 0 0 2 2 2 1 SDA1 NUC130_3NT PF08158.7 KOG99726.1 - 4.7e-23 81.2 1.6 2.5e-22 78.8 0.4 2.5 2 0 0 2 2 2 1 NUC130/3NT domain TFIIB PF00382.14 KOG99727.1 - 8e-55 182.5 1.4 2.2e-27 94.6 0.2 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.8 KOG99727.1 - 1.5e-31 108.4 5.6 1.5e-31 108.4 3.9 3.6 2 2 1 3 3 3 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.7 KOG99727.1 - 6.5e-10 38.1 2.5 1.4e-09 37.1 1.7 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.18 KOG99727.1 - 4.5e-05 23.0 1.0 0.043 13.3 0.1 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain CPDase PF07823.6 KOG99728.1 - 3.6e-72 242.0 0.1 4.2e-72 241.7 0.1 1.1 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.1 KOG99728.1 - 0.00064 19.4 0.1 0.0019 17.9 0.1 1.7 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily CAT PF00302.13 KOG99728.1 - 0.019 14.5 0.0 0.043 13.4 0.0 1.5 1 1 0 1 1 1 0 Chloramphenicol acetyltransferase DUF4621 PF15414.1 KOG99728.1 - 0.12 10.9 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4621) Glucosamine_iso PF01182.15 KOG99729.1 - 4.1e-51 173.5 0.0 4.8e-51 173.3 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase HSF_DNA-bind PF00447.12 KOG99731.1 - 5.3e-28 97.2 0.9 1.6e-27 95.6 0.6 1.9 1 0 0 1 1 1 1 HSF-type DNA-binding Kinesin-related PF06548.6 KOG99731.1 - 0.093 11.2 3.9 0.14 10.6 2.7 1.1 1 0 0 1 1 1 0 Kinesin-related Macoilin PF09726.4 KOG99731.1 - 0.23 9.6 10.3 0.29 9.3 7.2 1.1 1 0 0 1 1 1 0 Transmembrane protein RRM_1 PF00076.17 KOG99732.1 - 1.2e-32 111.3 1.2 1e-11 44.2 0.0 5.7 5 1 1 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG99732.1 - 1.4e-19 69.7 0.0 8.6e-07 28.8 0.0 4.0 3 1 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG99732.1 - 3.7e-14 52.2 0.3 0.0021 17.8 0.0 3.9 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2702 PF10863.3 KOG99733.1 - 1.8e-58 196.3 6.4 2.9e-58 195.6 4.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2702) YvbH_ext PF11724.3 KOG99733.1 - 0.33 10.6 2.6 22 4.8 0.1 3.0 2 1 1 3 3 3 0 YvbH-like oligomerisation region Bromodomain PF00439.20 KOG99734.1 - 2.6e-27 94.5 2.0 5.7e-27 93.4 1.4 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_7 PF13508.1 KOG99734.1 - 4.6e-09 36.3 0.2 9.8e-09 35.2 0.2 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 KOG99734.1 - 1.5e-08 34.5 0.0 2.6e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 KOG99734.1 - 0.00084 19.3 0.1 0.0017 18.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOG99734.1 - 0.0014 18.7 0.0 0.0031 17.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Proteasome PF00227.21 KOG99735.1 - 5.4e-53 179.1 0.0 7e-53 178.7 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KOG99735.1 - 1.3e-13 49.9 0.1 3.9e-13 48.4 0.1 1.9 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Enolase_C PF00113.17 KOG99736.1 - 2.5e-151 502.6 0.0 3.4e-151 502.2 0.0 1.2 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 KOG99736.1 - 9.1e-55 184.1 0.3 1.7e-54 183.2 0.2 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.1 KOG99736.1 - 0.002 18.0 0.1 0.0075 16.2 0.0 2.0 2 0 0 2 2 2 1 Enolase C-terminal domain-like MAAL_C PF07476.6 KOG99736.1 - 0.014 14.3 0.2 0.055 12.4 0.0 1.9 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus MR_MLE PF01188.16 KOG99736.1 - 0.03 14.8 0.0 0.12 12.9 0.0 2.1 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain FAD_binding_3 PF01494.14 KOG99737.1 - 5.8e-19 68.3 0.4 4.6e-13 48.9 0.0 2.9 2 1 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.7 KOG99737.1 - 0.00014 20.9 0.0 0.017 14.0 0.0 3.0 3 0 0 3 3 3 1 Lycopene cyclase protein SE PF08491.5 KOG99737.1 - 0.00018 20.4 0.0 0.00031 19.6 0.0 1.3 1 0 0 1 1 1 1 Squalene epoxidase DAO PF01266.19 KOG99737.1 - 0.00037 19.5 0.0 0.042 12.7 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOG99737.1 - 0.005 16.7 0.0 0.0099 15.7 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 KOG99737.1 - 0.025 13.4 0.0 0.053 12.3 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.1 KOG99737.1 - 0.033 14.1 0.0 0.083 12.9 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 KOG99737.1 - 0.035 14.5 0.0 2.8 8.4 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KOG99737.1 - 0.042 13.6 0.0 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding Thi4 PF01946.12 KOG99737.1 - 0.045 12.8 0.0 0.11 11.5 0.0 1.6 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.1 KOG99737.1 - 0.061 13.3 0.0 0.2 11.7 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOG99737.1 - 0.085 11.3 0.0 0.13 10.6 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.9 KOG99737.1 - 0.096 11.2 0.0 0.52 8.8 0.0 2.1 3 0 0 3 3 3 0 Tryptophan halogenase 6PGD PF00393.14 KOG99738.1 - 7.5e-132 438.9 0.0 9.1e-132 438.6 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 KOG99738.1 - 8.2e-51 172.0 0.0 1.2e-50 171.5 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 KOG99738.1 - 0.035 14.1 0.0 0.14 12.2 0.0 2.0 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.14 KOG99738.1 - 0.081 12.0 0.1 0.23 10.6 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.12 KOG99738.1 - 0.12 12.8 0.2 0.21 12.0 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.13 KOG99738.1 - 0.13 11.8 0.1 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Mito_carr PF00153.22 KOG99739.1 - 8.5e-62 204.8 0.1 9.8e-23 79.6 0.0 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein XPG_N PF00752.12 KOG99740.1 - 1.4e-37 128.0 0.1 4.5e-37 126.3 0.0 2.0 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.13 KOG99740.1 - 3.2e-26 91.2 0.0 1.2e-25 89.3 0.0 2.1 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.15 KOG99740.1 - 0.001 19.2 0.0 0.0038 17.4 0.0 2.0 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.2 KOG99740.1 - 0.0038 16.7 0.0 0.0088 15.5 0.0 1.7 1 0 0 1 1 1 1 XPG domain containing MFS_1 PF07690.11 KOG99741.1 - 1.8e-32 112.4 25.4 2.7e-32 111.8 17.3 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily ZYG-11_interact PF05884.7 KOG99741.1 - 0.98 8.4 7.1 0.15 11.0 2.0 1.7 2 0 0 2 2 2 0 Interactor of ZYG-11 Adaptin_N PF01602.15 KOG99742.1 - 1.8e-134 448.9 14.4 2.3e-134 448.5 10.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 KOG99742.1 - 3.6e-16 59.2 1.0 8.9e-09 35.5 0.0 5.2 6 0 0 6 6 6 3 HEAT repeats HEAT PF02985.17 KOG99742.1 - 2.4e-10 39.6 7.2 0.016 15.2 0.0 6.2 6 0 0 6 6 6 3 HEAT repeat Cnd1 PF12717.2 KOG99742.1 - 9.8e-06 25.5 0.3 9.8e-06 25.5 0.2 3.6 4 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 UNC45-central PF11701.3 KOG99742.1 - 0.0061 16.2 3.6 0.19 11.3 0.0 3.5 3 1 0 3 3 3 1 Myosin-binding striated muscle assembly central Vac14_Fab1_bd PF12755.2 KOG99742.1 - 0.026 14.8 0.1 0.63 10.4 0.0 3.2 2 1 0 2 2 2 0 Vacuolar 14 Fab1-binding region Cohesin_HEAT PF12765.2 KOG99742.1 - 0.031 14.2 0.3 0.67 9.9 0.0 3.0 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion HEAT_EZ PF13513.1 KOG99742.1 - 0.033 14.7 11.7 6.4 7.4 0.0 6.1 7 1 1 8 8 8 0 HEAT-like repeat Kdo PF06293.9 KOG99743.1 - 8.1e-08 31.5 0.0 1.2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 KOG99743.1 - 2.9e-05 23.3 0.0 3.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 KOG99743.1 - 0.00019 21.2 0.6 0.029 14.1 0.2 2.2 1 1 0 2 2 2 2 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 KOG99743.1 - 0.021 13.9 0.0 0.03 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase DUF1679 PF07914.6 KOG99743.1 - 0.074 11.6 0.0 0.1 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) DUF2424 PF10340.4 KOG99744.1 - 1.8e-158 527.0 1.9 2.1e-158 526.8 1.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_3 PF07859.8 KOG99744.1 - 4.8e-13 49.1 0.0 7e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOG99744.1 - 0.0044 16.7 0.0 0.0062 16.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family tRNA-synt_1g PF09334.6 KOG99745.1 - 9.5e-147 488.7 0.3 1.4e-146 488.2 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) MetRS-N PF09635.5 KOG99745.1 - 1e-49 167.9 6.4 2.1e-49 166.9 4.4 1.6 1 0 0 1 1 1 1 MetRS-N binding domain tRNA-synt_1 PF00133.17 KOG99745.1 - 4.3e-09 34.9 0.7 0.0021 16.1 0.0 2.6 1 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) PhoD PF09423.5 KOG99746.1 - 6.4e-05 21.7 1.8 0.00028 19.6 1.2 1.9 1 1 0 1 1 1 1 PhoD-like phosphatase GTP_cyclohydroI PF01227.17 KOG99747.1 - 5e-75 250.6 0.2 6.1e-75 250.4 0.1 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.1 KOG99747.1 - 1.1e-05 25.2 0.0 3.1e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 QueF-like protein OmpH PF03938.9 KOG99747.1 - 0.0023 17.8 0.1 1.3 8.9 0.0 2.1 2 0 0 2 2 2 2 Outer membrane protein (OmpH-like) DnaJ_CXXCXGXG PF00684.14 KOG99748.1 - 2.2e-05 24.3 5.7 0.026 14.5 0.3 2.5 2 0 0 2 2 2 2 DnaJ central domain HypA PF01155.14 KOG99748.1 - 0.051 13.2 2.4 0.32 10.6 0.2 2.1 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-RING_5 PF14634.1 KOG99748.1 - 0.14 11.8 3.5 13 5.6 0.1 3.2 3 0 0 3 3 3 0 zinc-RING finger domain Cytochrom_c3_2 PF14537.1 KOG99748.1 - 0.63 10.4 5.5 20 5.5 2.9 2.4 2 1 0 2 2 2 0 Cytochrome c3 DUF605 PF04652.11 KOG99748.1 - 4.7 6.4 16.0 5.5 6.2 11.1 1.0 1 0 0 1 1 1 0 Vta1 like DZR PF12773.2 KOG99748.1 - 5.8 6.8 7.8 2.2 8.1 0.4 2.6 2 1 0 2 2 2 0 Double zinc ribbon PAT1 PF09770.4 KOG99748.1 - 8.6 4.4 7.4 9.7 4.2 5.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AAA PF00004.24 KOG99749.1 - 4.8e-50 169.1 0.0 1.1e-42 145.3 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 KOG99749.1 - 3.2e-07 30.4 0.0 1e-05 25.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 KOG99749.1 - 6.5e-07 29.5 0.0 2.8e-05 24.1 0.0 3.0 2 1 0 2 2 2 1 AAA ATPase domain Bromodomain PF00439.20 KOG99749.1 - 3.1e-05 23.8 0.0 0.0001 22.1 0.0 1.9 1 0 0 1 1 1 1 Bromodomain AAA_22 PF13401.1 KOG99749.1 - 5e-05 23.4 0.9 0.002 18.2 0.1 3.2 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 KOG99749.1 - 5.4e-05 22.6 0.0 0.00017 21.0 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_5 PF07728.9 KOG99749.1 - 0.00013 21.7 0.0 0.00044 19.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 KOG99749.1 - 0.00014 21.7 0.0 0.0064 16.3 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOG99749.1 - 0.0013 18.4 0.0 0.023 14.4 0.0 2.5 2 0 0 2 2 2 1 Part of AAA domain ResIII PF04851.10 KOG99749.1 - 0.0015 18.4 0.1 0.016 15.0 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.1 KOG99749.1 - 0.0025 17.8 0.0 0.33 11.0 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain TIP49 PF06068.8 KOG99749.1 - 0.007 15.1 0.0 0.019 13.7 0.0 1.6 2 0 0 2 2 2 1 TIP49 C-terminus AAA_17 PF13207.1 KOG99749.1 - 0.008 16.9 0.0 0.008 16.9 0.0 3.9 4 1 0 4 4 1 1 AAA domain AAA_33 PF13671.1 KOG99749.1 - 0.0087 15.9 0.0 0.029 14.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 KOG99749.1 - 0.011 15.1 0.0 0.037 13.4 0.0 1.9 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOG99749.1 - 0.016 15.3 0.0 0.072 13.2 0.0 2.2 2 0 0 2 2 1 0 RNA helicase Sigma54_activat PF00158.21 KOG99749.1 - 0.023 14.1 0.0 0.63 9.4 0.0 3.0 2 1 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.16 KOG99749.1 - 0.031 13.4 0.0 0.12 11.5 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.22 KOG99749.1 - 0.043 14.1 0.0 0.043 14.1 0.0 3.8 4 1 0 4 4 2 0 ABC transporter AAA_30 PF13604.1 KOG99749.1 - 0.046 13.3 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 KOG99749.1 - 0.064 12.4 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_3 PF07726.6 KOG99749.1 - 0.068 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOG99749.1 - 0.074 12.0 0.0 0.15 11.0 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.1 KOG99749.1 - 0.19 12.0 0.0 0.19 12.0 0.0 3.6 3 0 0 3 3 2 0 AAA domain Sec63 PF02889.11 KOG99750.1 - 9.4e-137 455.4 2.3 7.6e-94 314.4 0.1 2.4 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 KOG99750.1 - 1.3e-50 171.1 9.2 1.7e-27 95.9 0.7 4.7 5 0 0 5 5 5 2 DEAD/DEAH box helicase ResIII PF04851.10 KOG99750.1 - 1.5e-20 73.8 3.9 2.4e-09 37.2 0.2 3.0 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 KOG99750.1 - 3.2e-17 62.1 0.0 9.3e-08 31.8 0.0 2.9 2 0 0 2 2 2 2 Helicase conserved C-terminal domain SNF2_N PF00176.18 KOG99750.1 - 1.9e-08 33.4 0.3 0.00021 20.2 0.1 2.4 2 0 0 2 2 2 2 SNF2 family N-terminal domain AAA_22 PF13401.1 KOG99750.1 - 0.00013 22.0 8.2 0.21 11.7 0.2 5.1 3 2 2 5 5 5 2 AAA domain PhoH PF02562.11 KOG99750.1 - 0.00023 20.4 0.5 0.16 11.2 0.0 3.1 4 0 0 4 4 4 2 PhoH-like protein AAA PF00004.24 KOG99750.1 - 0.00032 20.8 7.7 0.078 13.1 0.0 4.7 5 2 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 KOG99750.1 - 0.0025 17.5 0.0 2.5 7.9 0.0 2.6 2 0 0 2 2 2 2 Part of AAA domain IstB_IS21 PF01695.12 KOG99750.1 - 0.0028 17.0 2.4 2.1 7.7 0.0 4.6 6 0 0 6 6 6 1 IstB-like ATP binding protein AAA_10 PF12846.2 KOG99750.1 - 0.89 8.9 5.3 56 3.0 0.0 4.4 4 2 1 6 6 6 0 AAA-like domain DUF2361 PF10153.4 KOG99751.1 - 3.9e-37 126.9 15.4 7.1e-37 126.0 10.7 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2361) tRNA-synt_1c_C PF03950.13 KOG99751.1 - 0.052 13.2 0.8 0.096 12.3 0.5 1.6 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), anti-codon binding domain Plasmid_parti PF01672.11 KOG99751.1 - 0.47 10.9 7.5 0.14 12.6 2.9 1.9 2 0 0 2 2 2 0 Putative plasmid partition protein DUF2406 PF10295.4 KOG99752.1 - 1.1e-23 83.4 0.1 2.6e-23 82.3 0.1 1.7 1 0 0 1 1 1 1 Uncharacterised protein (DUF2406) DUF3591 PF12157.3 KOG99753.1 - 9.9e-194 643.9 3.9 1.9e-193 643.0 2.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.1 KOG99753.1 - 3.9e-06 26.4 0.3 7.7e-06 25.4 0.2 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.18 KOG99753.1 - 0.23 11.4 0.3 0.55 10.2 0.2 1.6 1 0 0 1 1 1 0 Zinc knuckle Rtt102p PF09510.5 KOG99754.1 - 3e-40 137.2 0.1 4e-40 136.8 0.1 1.2 1 0 0 1 1 1 1 Rtt102p-like transcription regulator protein DUF834 PF05754.9 KOG99754.1 - 0.17 11.7 1.8 0.19 11.5 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF834) RNase_T PF00929.19 KOG99755.1 - 2.7e-29 102.5 0.1 7.8e-29 101.0 0.0 1.8 2 0 0 2 2 2 1 Exonuclease CTP_transf_2 PF01467.21 KOG99756.1 - 4.5e-20 72.2 0.0 6.3e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase Glyco_hydro_17 PF00332.13 KOG99757.1 - 1.3e-11 44.1 0.5 3.5e-11 42.7 0.3 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 RAP1 PF07218.6 KOG99757.1 - 6.7 4.6 7.6 9.6 4.1 5.2 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) G-patch PF01585.18 KOG99758.1 - 9.1e-11 41.3 0.0 1.8e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 G-patch domain YL1 PF05764.8 KOG99758.1 - 1.1e-05 25.1 25.9 1.7e-05 24.5 18.0 1.3 1 0 0 1 1 1 1 YL1 nuclear protein Nop14 PF04147.7 KOG99758.1 - 0.00028 18.9 20.3 0.00032 18.7 14.1 1.1 1 0 0 1 1 1 1 Nop14-like family G-patch_2 PF12656.2 KOG99758.1 - 0.00031 20.5 0.1 0.00031 20.5 0.0 3.8 2 1 0 2 2 1 1 DExH-box splicing factor binding site eIF3_subunit PF08597.5 KOG99758.1 - 0.084 12.4 36.2 0.14 11.6 25.1 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Hex_IIIa PF02455.11 KOG99758.1 - 0.22 10.1 6.6 0.24 10.0 4.6 1.1 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) CDC45 PF02724.9 KOG99758.1 - 0.24 9.3 28.0 0.34 8.9 19.4 1.1 1 0 0 1 1 1 0 CDC45-like protein MIP-T3 PF10243.4 KOG99758.1 - 0.49 8.8 33.6 0.67 8.3 23.3 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF2201_N PF13203.1 KOG99758.1 - 0.76 8.8 12.5 1 8.4 8.7 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Spt5_N PF11942.3 KOG99758.1 - 1.2 9.8 26.7 0.23 12.1 15.9 1.8 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Hid1 PF12722.2 KOG99758.1 - 2.1 5.9 17.5 2.5 5.6 12.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pox_RNA_Pol_19 PF05320.7 KOG99758.1 - 2.3 7.9 15.3 3.9 7.2 10.6 1.4 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit YqfQ PF14181.1 KOG99758.1 - 3.3 7.7 23.4 6.7 6.7 16.2 1.6 1 0 0 1 1 1 0 YqfQ-like protein DUF1510 PF07423.6 KOG99758.1 - 3.6 6.9 31.4 0.88 8.8 19.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Zip PF02535.17 KOG99758.1 - 6.1 5.7 14.1 7.7 5.4 9.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2422 PF10337.4 KOG99758.1 - 6.2 5.4 8.0 8.8 4.9 5.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) ABC_membrane PF00664.18 KOG99759.1 - 5.4e-73 245.7 39.5 3.8e-41 141.3 10.2 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 KOG99759.1 - 8.9e-46 155.5 4.7 2.2e-28 99.2 0.0 3.6 3 1 0 3 3 2 2 ABC transporter AAA_23 PF13476.1 KOG99759.1 - 1.2e-11 45.3 9.1 4.5e-08 33.6 0.9 3.5 3 0 0 3 3 3 2 AAA domain SMC_N PF02463.14 KOG99759.1 - 1.5e-09 37.4 6.2 0.044 13.0 0.3 4.4 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 KOG99759.1 - 9.6e-09 34.6 1.6 0.00063 19.2 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.1 KOG99759.1 - 5.1e-07 29.9 13.2 4.6e-05 23.5 0.0 5.5 4 2 0 5 5 4 1 AAA domain AAA_17 PF13207.1 KOG99759.1 - 8.2e-07 29.8 1.5 0.064 14.0 0.0 3.6 4 0 0 4 4 2 2 AAA domain DUF258 PF03193.11 KOG99759.1 - 9.3e-07 28.1 0.3 0.0019 17.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 KOG99759.1 - 1.3e-05 25.0 0.3 0.21 11.5 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_10 PF12846.2 KOG99759.1 - 5e-05 22.8 0.9 0.18 11.2 0.0 2.9 2 1 0 2 2 2 2 AAA-like domain T2SE PF00437.15 KOG99759.1 - 9e-05 21.4 0.0 0.026 13.4 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein Miro PF08477.8 KOG99759.1 - 0.00016 22.1 0.1 1.3 9.5 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein Zeta_toxin PF06414.7 KOG99759.1 - 0.00021 20.4 0.0 0.018 14.1 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_25 PF13481.1 KOG99759.1 - 0.00025 20.5 0.0 0.12 11.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 KOG99759.1 - 0.00041 19.2 3.0 1.2 7.7 0.0 3.3 3 0 0 3 3 3 1 ArgK protein AAA_16 PF13191.1 KOG99759.1 - 0.0018 18.2 0.1 0.075 13.0 0.0 2.7 3 0 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.1 KOG99759.1 - 0.0019 18.3 7.7 1 9.4 0.1 4.2 3 1 0 3 3 3 2 AAA domain AAA_18 PF13238.1 KOG99759.1 - 0.0028 17.9 12.4 0.13 12.5 0.0 4.9 6 0 0 6 6 4 2 AAA domain FtsK_SpoIIIE PF01580.13 KOG99759.1 - 0.0028 17.1 0.1 0.72 9.2 0.0 2.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_30 PF13604.1 KOG99759.1 - 0.0035 16.9 3.6 0.4 10.2 0.0 3.1 4 0 0 4 4 3 1 AAA domain TrwB_AAD_bind PF10412.4 KOG99759.1 - 0.0059 15.2 0.1 1.4 7.4 0.1 2.4 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain IstB_IS21 PF01695.12 KOG99759.1 - 0.006 16.0 1.4 0.29 10.5 0.0 3.3 5 0 0 5 5 3 1 IstB-like ATP binding protein RNA_helicase PF00910.17 KOG99759.1 - 0.0063 16.6 0.1 9.9 6.3 0.0 3.7 3 0 0 3 3 3 0 RNA helicase AAA_14 PF13173.1 KOG99759.1 - 0.0066 16.3 0.1 2.6 7.9 0.0 3.8 3 0 0 3 3 3 1 AAA domain ATP-synt_ab PF00006.20 KOG99759.1 - 0.011 15.2 0.1 3.6 7.0 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.10 KOG99759.1 - 0.023 14.3 0.3 3.5 7.2 0.0 2.6 2 0 0 2 2 2 0 NTPase AAA_28 PF13521.1 KOG99759.1 - 0.03 14.3 1.1 0.81 9.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA PF00004.24 KOG99759.1 - 0.036 14.2 0.9 0.61 10.2 0.1 3.2 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.12 KOG99759.1 - 0.065 13.0 0.1 0.065 13.0 0.1 2.5 3 0 0 3 3 1 0 Domain of unknown function DUF87 cobW PF02492.14 KOG99759.1 - 0.07 12.5 2.5 1.9 7.9 0.0 3.1 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 KOG99759.1 - 0.19 11.6 0.0 28 4.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 KOG99759.1 - 0.21 11.2 0.0 0.21 11.2 0.0 3.9 4 1 0 4 4 3 0 Archaeal ATPase Dynamin_N PF00350.18 KOG99759.1 - 0.79 9.5 10.3 0.56 10.0 0.0 3.4 4 0 0 4 4 3 0 Dynamin family Glyco_hydro_17 PF00332.13 KOG99760.1 - 2.5e-77 259.9 2.4 2.8e-77 259.7 1.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 DUF1088 PF06469.6 KOG99760.1 - 0.045 13.1 0.0 0.091 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1088) Phage-A118_gp45 PF10653.4 KOG99760.1 - 0.077 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein gp45 of Bacteriophage A118 Methyltrn_RNA_3 PF02598.12 KOG99761.1 - 1.1e-78 264.5 0.1 1.3e-78 264.2 0.1 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase SURF4 PF02077.10 KOG99762.1 - 2.3e-110 368.1 11.3 2.7e-110 367.9 7.8 1.0 1 0 0 1 1 1 1 SURF4 family DUF4516 PF14990.1 KOG99762.1 - 7.5 6.1 6.7 0.65 9.6 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4516) DnaJ PF00226.26 KOG99763.1 - 3.5e-16 58.6 0.2 3.5e-16 58.6 0.2 2.5 2 0 0 2 2 2 1 DnaJ domain BATS PF06968.8 KOG99764.1 - 8.3e-29 99.2 0.3 2.3e-28 97.8 0.0 1.9 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.16 KOG99764.1 - 2.2e-17 63.7 0.5 7.8e-17 61.9 0.1 1.9 2 0 0 2 2 2 1 Radical SAM superfamily SRP1_TIP1 PF00660.12 KOG99765.1 - 2.5e-32 110.8 0.1 3.1e-32 110.4 0.1 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family CorA PF01544.13 KOG99766.1 - 1.7e-37 129.0 3.7 2.6e-22 79.2 0.0 2.2 1 1 0 2 2 2 2 CorA-like Mg2+ transporter protein S-methyl_trans PF02574.11 KOG99767.1 - 3.6e-95 318.7 0.0 4.1e-95 318.6 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Kelch_1 PF01344.20 KOG99767.1 - 0.062 12.8 0.1 0.63 9.6 0.0 2.4 2 0 0 2 2 2 0 Kelch motif AA_permease PF00324.16 KOG99768.1 - 7.6e-36 123.4 7.3 9.2e-36 123.1 5.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG99768.1 - 6.1e-12 44.7 7.9 7.3e-12 44.5 5.5 1.1 1 0 0 1 1 1 1 Amino acid permease ATP_synt_H PF05493.8 KOG99768.1 - 0.022 14.8 1.0 0.022 14.8 0.7 2.0 2 0 0 2 2 2 0 ATP synthase subunit H UPF0104 PF03706.8 KOG99768.1 - 0.069 12.4 3.5 0.11 11.7 2.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0104) Asp PF00026.18 KOG99769.1 - 9.2e-58 195.9 9.7 1.3e-57 195.4 6.8 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOG99769.1 - 2.6e-10 40.4 0.1 1.9e-09 37.7 0.0 2.5 3 1 0 3 3 3 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 KOG99769.1 - 1.5e-07 31.7 0.7 0.34 11.4 0.0 3.5 3 0 0 3 3 3 3 Aspartyl protease TAXi_C PF14541.1 KOG99769.1 - 0.00041 19.9 0.1 0.01 15.4 0.1 2.4 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.1 KOG99769.1 - 0.0029 17.3 0.0 1.5 8.6 0.0 2.3 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease ADH_zinc_N PF00107.21 KOG99770.1 - 1.7e-14 53.4 0.1 2.6e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOG99770.1 - 0.00047 19.8 0.2 0.0046 16.6 0.1 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Semialdhyde_dh PF01118.19 KOG99770.1 - 0.036 14.3 0.0 0.055 13.7 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.1 KOG99770.1 - 0.13 13.1 0.0 0.23 12.3 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Flocculin_t3 PF13928.1 KOG99771.1 - 3.9e-47 158.1 141.5 1.9e-13 50.2 15.5 6.7 6 0 0 6 6 6 4 Flocculin type 3 repeat ArsD PF06953.6 KOG99771.1 - 3.9 7.6 22.3 17 5.5 0.4 4.5 4 1 0 4 4 4 0 Arsenical resistance operon trans-acting repressor ArsD PA14 PF07691.7 KOG99772.1 - 3.7e-22 78.5 0.0 7.4e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 PA14 domain PA14_2 PF10528.4 KOG99772.1 - 4.9e-12 45.8 0.8 4.9e-12 45.8 0.5 2.1 2 0 0 2 2 2 1 GLEYA domain Flocculin PF00624.13 KOG99772.1 - 2.8e-07 30.2 14.6 2.8e-07 30.2 10.1 4.7 5 0 0 5 5 5 1 Flocculin repeat Colipase_C PF02740.9 KOG99772.1 - 0.015 15.0 0.2 0.046 13.4 0.1 1.9 1 0 0 1 1 1 0 Colipase, C-terminal domain CorA PF01544.13 KOG99773.1 - 1.4e-39 135.9 1.8 3.2e-25 88.7 0.0 2.2 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein CRC_subunit PF08624.5 KOG99774.1 - 5e-37 126.9 0.2 9.6e-37 125.9 0.1 1.5 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Lectin_leg-like PF03388.8 KOG99775.1 - 1.8e-60 203.9 0.1 2.8e-60 203.2 0.1 1.3 1 0 0 1 1 1 1 Legume-like lectin family FCH PF00611.18 KOG99776.1 - 3.1e-16 59.3 0.0 3.1e-16 59.3 0.0 2.9 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain DEP PF00610.16 KOG99776.1 - 3.5e-10 39.4 0.1 1.4e-09 37.5 0.0 2.2 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RhoGAP PF00620.22 KOG99776.1 - 7.9e-08 32.0 5.0 3.3e-07 30.0 0.0 3.2 3 1 0 3 3 3 1 RhoGAP domain DUF1640 PF07798.6 KOG99777.1 - 2e-63 213.5 8.0 2.3e-63 213.4 5.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) DUF3523 PF12037.3 KOG99777.1 - 0.0015 17.5 6.3 0.0019 17.2 4.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) DUF3584 PF12128.3 KOG99777.1 - 0.006 13.9 7.0 0.0075 13.6 4.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) FlaC_arch PF05377.6 KOG99777.1 - 0.0075 16.1 4.3 0.25 11.2 0.2 2.5 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) FTA4 PF13093.1 KOG99777.1 - 0.055 12.9 4.6 0.07 12.5 3.2 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 ApoLp-III PF07464.6 KOG99777.1 - 0.061 13.3 4.3 0.087 12.8 3.0 1.3 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF2407_C PF13373.1 KOG99777.1 - 0.14 12.0 1.3 0.36 10.7 0.9 1.7 1 1 0 1 1 1 0 DUF2407 C-terminal domain HALZ PF02183.13 KOG99777.1 - 0.19 11.4 2.5 0.66 9.7 0.5 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF3410 PF11890.3 KOG99777.1 - 0.36 10.4 2.9 0.69 9.6 1.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3410) Baculo_PEP_C PF04513.7 KOG99777.1 - 0.4 10.5 4.3 4.1 7.2 3.0 2.2 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.7 KOG99777.1 - 0.56 10.0 6.2 4.2 7.1 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF1732 PF08340.6 KOG99777.1 - 0.58 10.0 7.6 0.77 9.6 4.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1732) Apolipoprotein PF01442.13 KOG99777.1 - 0.75 9.2 6.9 2.4 7.6 4.8 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain TBPIP PF07106.8 KOG99777.1 - 0.88 9.1 10.6 2 7.9 7.4 1.6 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF342 PF03961.8 KOG99777.1 - 1 7.7 8.5 1.5 7.1 5.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Phage_lysis PF03245.8 KOG99777.1 - 1 9.3 6.6 0.65 9.9 0.2 2.3 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein YlqD PF11068.3 KOG99777.1 - 1.4 8.9 11.5 2.4 8.2 3.4 2.1 1 1 1 2 2 2 0 YlqD protein Syntaxin PF00804.20 KOG99777.1 - 4.1 7.6 13.3 8.8 6.5 5.6 2.3 1 1 1 2 2 2 0 Syntaxin PMM PF03332.8 KOG99778.1 - 1.1e-114 381.4 0.3 1.3e-114 381.2 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.7 KOG99778.1 - 2e-05 24.3 0.0 0.00043 19.9 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TMPIT PF07851.8 KOG99778.1 - 0.023 13.8 0.0 0.03 13.4 0.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein Chordopox_A13L PF05961.6 KOG99778.1 - 0.16 11.9 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirus A13L protein OTU PF02338.14 KOG99779.1 - 5.6e-15 55.9 0.0 1.1e-14 55.1 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease DUF764 PF05561.6 KOG99779.1 - 0.004 16.6 0.2 0.0071 15.7 0.2 1.4 1 0 0 1 1 1 1 Borrelia burgdorferi protein of unknown function (DUF764) Nab2 PF11517.3 KOG99779.1 - 0.017 15.1 0.3 0.037 14.0 0.2 1.5 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) FeoA PF04023.9 KOG99779.1 - 0.11 12.4 0.0 0.3 11.0 0.0 1.8 1 0 0 1 1 1 0 FeoA domain GRAM PF02893.15 KOG99780.1 - 1.5e-19 69.2 0.1 3.9e-19 67.9 0.0 1.8 2 0 0 2 2 2 1 GRAM domain Herpes_BLLF1 PF05109.8 KOG99780.1 - 0.42 8.5 7.4 0.62 7.9 5.2 1.2 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Cu-oxidase_2 PF07731.9 KOG99781.1 - 2.8e-40 137.0 7.2 2.3e-37 127.5 0.5 3.0 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.10 KOG99781.1 - 1.1e-38 131.6 5.2 1.3e-36 124.8 0.3 2.9 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 KOG99781.1 - 1e-36 126.2 5.1 1.3e-33 116.1 0.4 3.5 3 1 0 3 3 3 2 Multicopper oxidase ADH_zinc_N PF00107.21 KOG99781.1 - 0.039 13.5 0.0 0.078 12.5 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase E1_DerP2_DerF2 PF02221.10 KOG99781.1 - 0.11 12.7 0.0 0.32 11.2 0.0 1.8 1 0 0 1 1 1 0 ML domain Sugar_tr PF00083.19 KOG99782.1 - 5.7e-60 203.1 27.4 7e-60 202.8 19.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG99782.1 - 5.2e-16 58.2 34.2 2.1e-14 53.0 10.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Actin PF00022.14 KOG99783.1 - 2.2e-154 513.6 0.0 2.4e-154 513.5 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 KOG99783.1 - 0.04 14.3 0.0 0.17 12.2 0.0 2.0 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Ras PF00071.17 KOG99784.1 - 3.7e-64 214.9 0.5 4.6e-64 214.6 0.3 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG99784.1 - 8.6e-20 71.4 0.4 1.5e-19 70.6 0.1 1.6 2 0 0 2 2 1 1 Miro-like protein Arf PF00025.16 KOG99784.1 - 7.3e-17 61.1 0.4 9.6e-17 60.7 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOG99784.1 - 1.7e-06 27.3 0.2 2.4e-06 26.8 0.2 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOG99784.1 - 1.5e-05 24.4 0.1 3.5e-05 23.3 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOG99784.1 - 6.3e-05 22.9 0.1 0.00012 21.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KOG99784.1 - 0.0034 16.6 0.9 0.0038 16.4 0.1 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 KOG99784.1 - 0.0046 15.6 4.4 0.024 13.3 0.0 2.6 1 1 1 2 2 2 1 G-protein alpha subunit AAA_22 PF13401.1 KOG99784.1 - 0.014 15.5 0.0 0.03 14.4 0.0 1.6 1 1 1 2 2 2 0 AAA domain DUF258 PF03193.11 KOG99784.1 - 0.019 14.1 0.0 0.037 13.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 YTH PF04146.10 KOG99784.1 - 0.021 14.3 0.0 0.035 13.6 0.0 1.4 1 1 0 1 1 1 0 YT521-B-like domain Septin PF00735.13 KOG99784.1 - 0.055 12.4 0.3 0.18 10.8 0.0 1.8 2 0 0 2 2 2 0 Septin AAA_5 PF07728.9 KOG99784.1 - 0.064 12.9 0.1 0.14 11.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.1 KOG99784.1 - 0.066 12.7 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.1 KOG99784.1 - 0.082 12.8 0.2 0.22 11.4 0.1 1.8 2 1 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.22 KOG99784.1 - 0.11 12.7 1.5 0.57 10.4 1.1 2.1 1 1 0 1 1 1 0 ABC transporter Tubulin PF00091.20 KOG99785.1 - 1.6e-70 237.3 0.0 2.8e-70 236.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KOG99785.1 - 4.2e-48 162.5 0.1 8.7e-48 161.5 0.0 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 KOG99785.1 - 0.0026 17.2 0.0 0.0047 16.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.4 KOG99785.1 - 0.011 15.7 0.0 0.028 14.4 0.0 1.7 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain MVL PF12151.3 KOG99785.1 - 0.088 12.4 0.0 0.28 10.8 0.0 1.9 1 0 0 1 1 1 0 Mannan-binding protein RNA_pol PF00940.14 KOG99786.1 - 2.3e-162 540.0 0.0 4e-162 539.3 0.0 1.4 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.1 KOG99786.1 - 2.5e-91 306.2 0.1 4.5e-91 305.4 0.1 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal Mob1_phocein PF03637.12 KOG99787.1 - 5.4e-74 247.6 1.5 8.5e-74 246.9 1.0 1.3 1 0 0 1 1 1 1 Mob1/phocein family DUF726 PF05277.7 KOG99788.1 - 2.8e-139 463.8 2.0 2.8e-139 463.8 1.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF726) Pkinase PF00069.20 KOG99789.1 - 3.8e-60 203.2 0.0 5.6e-37 127.2 0.0 2.9 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99789.1 - 1.5e-23 83.2 0.0 2.4e-19 69.4 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.19 KOG99789.1 - 2.8e-07 30.5 0.0 5.2e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.1 KOG99789.1 - 2.5e-05 23.3 0.0 0.00017 20.6 0.0 2.3 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 KOG99789.1 - 0.00042 19.4 0.0 0.00092 18.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOG99789.1 - 0.00066 19.4 0.0 0.16 11.6 0.2 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family bZIP_2 PF07716.10 KOG99790.1 - 6.2e-06 25.9 7.5 6.2e-06 25.9 5.2 1.7 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.16 KOG99790.1 - 0.00014 21.7 7.6 0.00024 20.9 5.2 1.4 1 0 0 1 1 1 1 bZIP transcription factor DUF2360 PF10152.4 KOG99790.1 - 0.061 13.6 0.6 0.11 12.7 0.1 1.6 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) Aminotran_5 PF00266.14 KOG99791.1 - 2.6e-20 72.5 0.0 3.3e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Pkinase PF00069.20 KOG99792.1 - 6.6e-26 91.0 0.0 9.1e-25 87.2 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99792.1 - 6.1e-14 51.7 0.0 8.5e-14 51.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOG99792.1 - 0.0017 18.1 0.0 0.0029 17.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOG99792.1 - 0.0073 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 KOG99792.1 - 0.015 14.4 0.0 0.024 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CENP-O PF09496.5 KOG99792.1 - 0.096 12.9 0.1 0.18 12.0 0.1 1.5 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component ABC_tran PF00005.22 KOG99793.1 - 3.7e-17 62.9 0.0 8.5e-17 61.7 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOG99793.1 - 1.3e-09 38.4 0.1 1.4e-08 35.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 KOG99793.1 - 4.6e-05 22.7 0.0 0.1 11.7 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 KOG99793.1 - 0.00015 20.9 0.0 0.099 11.6 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 KOG99793.1 - 0.0021 17.5 0.1 0.0042 16.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_17 PF13207.1 KOG99793.1 - 0.0033 18.2 0.7 0.01 16.6 0.5 2.1 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 KOG99793.1 - 0.0039 16.6 0.1 0.0066 15.9 0.1 1.3 1 0 0 1 1 1 1 AAA-like domain AAA_24 PF13479.1 KOG99793.1 - 0.0073 15.9 0.1 0.016 14.7 0.0 1.6 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.18 KOG99793.1 - 0.012 15.3 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Dynamin family DUF258 PF03193.11 KOG99793.1 - 0.014 14.6 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_23 PF13476.1 KOG99793.1 - 0.025 14.9 0.0 0.033 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF3712 PF12505.3 KOG99793.1 - 0.071 13.1 0.1 0.54 10.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3712) FtsK_SpoIIIE PF01580.13 KOG99793.1 - 0.089 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_18 PF13238.1 KOG99793.1 - 0.092 13.0 1.3 0.23 11.7 0.2 2.1 2 1 0 2 2 2 0 AAA domain ArgK PF03308.11 KOG99793.1 - 0.12 11.1 0.0 0.22 10.2 0.0 1.4 1 1 0 1 1 1 0 ArgK protein DUF3584 PF12128.3 KOG99793.1 - 0.13 9.6 0.1 0.17 9.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) SRP54 PF00448.17 KOG99793.1 - 0.15 11.5 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.7 KOG99793.1 - 0.16 11.0 0.0 0.32 10.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RabGAP-TBC PF00566.13 KOG99794.1 - 1.2e-15 57.6 6.8 2.1e-15 56.7 3.8 2.1 2 1 0 2 2 2 1 Rab-GTPase-TBC domain PGAP1 PF07819.8 KOG99795.1 - 3.4e-90 301.5 0.1 8e-90 300.3 0.0 1.7 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_6 PF12697.2 KOG99795.1 - 0.00019 21.4 0.0 0.00033 20.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOG99795.1 - 0.00081 19.1 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOG99795.1 - 0.0037 16.8 0.0 0.0063 16.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF676 PF05057.9 KOG99795.1 - 0.051 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) LCAT PF02450.10 KOG99795.1 - 0.1 11.5 0.0 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase SKG6 PF08693.5 KOG99795.1 - 0.14 11.5 2.2 0.82 9.0 0.0 2.7 2 0 0 2 2 2 0 Transmembrane alpha-helix domain EPL1 PF10513.4 KOG99796.1 - 2.7e-31 108.9 2.4 2.7e-31 108.9 1.7 4.6 4 1 0 4 4 4 1 Enhancer of polycomb-like OmpH PF03938.9 KOG99796.1 - 0.00074 19.4 38.3 0.00086 19.2 13.1 2.7 2 0 0 2 2 2 2 Outer membrane protein (OmpH-like) SprA-related PF12118.3 KOG99796.1 - 0.15 11.3 42.3 0.058 12.7 16.5 2.4 2 0 0 2 2 2 0 SprA-related family DUF3835 PF12927.2 KOG99797.1 - 1.3e-18 67.7 0.4 1.3e-18 67.7 0.2 6.4 6 2 0 6 6 6 2 Domain of unknown function (DUF3835) Prefoldin PF02996.12 KOG99797.1 - 8.1e-15 54.5 0.5 3.2e-14 52.6 0.3 2.1 1 0 0 1 1 1 1 Prefoldin subunit HR1 PF02185.11 KOG99797.1 - 0.61 9.8 0.0 0.61 9.8 0.0 4.4 6 0 0 6 6 6 0 Hr1 repeat tRNA-synt_2d PF01409.15 KOG99798.1 - 8.4e-92 306.8 0.0 1.1e-91 306.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 KOG99798.1 - 3.3e-06 26.8 0.1 8.8e-06 25.4 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.15 KOG99798.1 - 8.3e-05 21.5 4.1 0.00022 20.1 0.1 3.0 2 2 1 4 4 4 1 tRNA synthetases class II (D, K and N) tRNA-synt_His PF13393.1 KOG99798.1 - 0.0011 18.1 0.1 0.0092 15.0 0.0 2.2 2 0 0 2 2 2 1 Histidyl-tRNA synthetase DUF465 PF04325.8 KOG99798.1 - 0.062 13.0 0.4 0.062 13.0 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF465) GATA PF00320.22 KOG99799.1 - 1.8e-15 56.0 3.9 8.9e-15 53.7 2.0 2.5 2 0 0 2 2 2 1 GATA zinc finger DUF1752 PF08550.5 KOG99799.1 - 2.1e-08 33.5 0.6 4.7e-08 32.4 0.4 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Pyr_redox_dim PF02852.17 KOG99801.1 - 1.8e-43 147.0 1.3 2.6e-43 146.5 0.1 2.0 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 KOG99801.1 - 9e-39 133.4 12.1 6.8e-37 127.3 8.4 3.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOG99801.1 - 9.6e-23 80.3 7.7 1.3e-19 70.3 0.4 3.5 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KOG99801.1 - 7.2e-12 45.1 0.5 1.1e-05 25.3 0.1 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 KOG99801.1 - 2.2e-11 43.5 5.9 2.1e-10 40.2 0.0 2.6 3 1 1 4 4 4 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 KOG99801.1 - 6e-10 39.5 1.0 3.7e-06 27.1 0.1 2.5 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 KOG99801.1 - 8.7e-10 38.0 1.9 8.7e-10 38.0 1.3 2.5 2 2 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.19 KOG99801.1 - 6.1e-08 31.9 2.0 6.1e-08 31.9 1.4 3.0 2 1 1 3 3 3 1 FAD binding domain DAO PF01266.19 KOG99801.1 - 9e-08 31.3 12.6 0.00051 19.0 0.7 4.0 2 2 2 4 4 4 3 FAD dependent oxidoreductase Thi4 PF01946.12 KOG99801.1 - 1.3e-06 27.7 0.9 0.00028 20.0 0.0 2.4 2 0 0 2 2 2 2 Thi4 family HI0933_like PF03486.9 KOG99801.1 - 1.5e-06 26.9 15.2 2.5e-05 22.9 0.6 4.4 4 1 1 5 5 5 3 HI0933-like protein AlaDh_PNT_C PF01262.16 KOG99801.1 - 3.1e-05 23.6 1.2 0.11 12.0 0.0 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.14 KOG99801.1 - 4.1e-05 22.7 9.4 0.0012 17.9 0.2 3.6 2 1 0 2 2 2 1 FAD binding domain K_oxygenase PF13434.1 KOG99801.1 - 0.00049 19.1 1.0 0.15 10.9 0.1 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.13 KOG99801.1 - 0.0011 18.6 5.9 0.0022 17.6 0.4 3.0 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.1 KOG99801.1 - 0.0017 18.6 0.0 1.9 8.7 0.0 2.5 2 0 0 2 2 2 2 XdhC Rossmann domain THF_DHG_CYH_C PF02882.14 KOG99801.1 - 0.0087 15.1 0.9 0.018 14.1 0.1 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Mqo PF06039.10 KOG99801.1 - 0.042 12.0 2.1 0.067 11.3 0.6 1.8 1 1 1 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Lycopene_cycl PF05834.7 KOG99801.1 - 0.065 12.1 4.2 0.13 11.1 0.3 2.5 3 0 0 3 3 3 0 Lycopene cyclase protein UDPG_MGDP_dh_N PF03721.9 KOG99801.1 - 0.12 11.7 4.8 0.56 9.5 0.5 2.7 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Trp_halogenase PF04820.9 KOG99801.1 - 0.13 10.8 3.5 0.096 11.2 0.2 2.2 3 0 0 3 3 3 0 Tryptophan halogenase LSM PF01423.17 KOG99802.1 - 3.3e-14 52.1 0.0 3.7e-14 52.0 0.0 1.0 1 0 0 1 1 1 1 LSM domain Acetyltransf_1 PF00583.19 KOG99803.1 - 2.6e-18 65.8 0.0 3.3e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOG99803.1 - 5.3e-11 42.5 0.0 7.7e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOG99803.1 - 7.6e-07 29.2 0.0 9.9e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 KOG99803.1 - 1.4e-06 28.1 0.0 3.3e-06 26.9 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KOG99803.1 - 1.9e-05 24.8 0.1 3.3e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 KOG99803.1 - 0.014 15.3 0.1 0.04 13.8 0.1 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOG99803.1 - 0.019 14.7 0.0 0.064 13.0 0.0 1.9 1 1 0 1 1 1 0 FR47-like protein Acetyltransf_CG PF14542.1 KOG99803.1 - 0.032 14.1 0.0 0.061 13.2 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_8 PF13523.1 KOG99803.1 - 0.096 12.5 0.0 0.26 11.1 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain GNAT_acetyltr_2 PF13718.1 KOG99803.1 - 0.11 11.7 0.0 0.47 9.7 0.0 2.0 2 1 1 3 3 3 0 GNAT acetyltransferase 2 DnaJ PF00226.26 KOG99804.1 - 2.1e-24 85.0 5.4 4.3e-24 84.0 3.8 1.6 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 KOG99804.1 - 1.4e-23 82.5 1.1 1.1e-17 63.6 0.1 3.0 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 KOG99804.1 - 1e-11 44.6 19.9 1.8e-11 43.8 13.8 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 KOG99804.1 - 0.012 15.3 1.2 0.012 15.3 0.8 2.4 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Cytochrome_C7 PF14522.1 KOG99804.1 - 0.15 11.6 13.1 0.23 11.1 8.3 1.9 1 1 0 1 1 1 0 Cytochrome c7 DUF2318 PF10080.4 KOG99804.1 - 1.2 9.0 6.4 0.29 10.9 0.3 2.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) DUF1924 PF09086.6 KOG99804.1 - 1.3 9.0 9.2 6.4 6.8 0.5 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF1924) HSP9_HSP12 PF04119.7 KOG99805.1 - 6.5e-27 93.3 4.4 8.6e-27 93.0 1.3 2.1 2 1 0 2 2 2 1 Heat shock protein 9/12 DUF883 PF05957.8 KOG99805.1 - 0.12 12.7 1.1 0.5 10.7 0.7 1.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DUF357 PF04010.8 KOG99805.1 - 0.15 11.8 0.4 2.4 7.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF357) DUF2585 PF10755.4 KOG99806.1 - 0.16 11.4 0.1 0.27 10.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2585) NT5C PF06941.7 KOG99807.1 - 0.051 13.0 0.1 0.072 12.5 0.1 1.3 1 0 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Sugar_tr PF00083.19 KOG99808.1 - 1.1e-170 568.0 35.6 1.3e-170 567.8 24.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOG99808.1 - 1.1e-34 119.6 33.1 7.6e-32 110.3 13.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOG99808.1 - 2.7e-05 22.7 11.2 2.7e-05 22.7 7.8 3.7 3 2 1 4 4 4 2 MFS/sugar transport protein Cytochrom_B_N PF00033.14 KOG99808.1 - 0.00057 19.3 4.6 0.0019 17.5 0.0 3.5 4 1 0 4 4 4 1 Cytochrome b(N-terminal)/b6/petB MFS_3 PF05977.8 KOG99808.1 - 0.00072 17.7 5.3 0.0076 14.4 1.5 2.3 2 0 0 2 2 2 2 Transmembrane secretion effector PDR_CDR PF06422.7 KOG99808.1 - 2.7 7.6 0.0 2.7 7.6 0.0 4.2 4 0 0 4 4 4 0 CDR ABC transporter WW PF00397.21 KOG99809.1 - 7.4e-08 32.1 1.0 7.4e-08 32.1 0.7 2.3 2 0 0 2 2 2 1 WW domain DUF605 PF04652.11 KOG99809.1 - 0.00062 19.2 11.5 0.00069 19.1 8.0 1.0 1 0 0 1 1 1 1 Vta1 like TFIIA PF03153.8 KOG99809.1 - 0.68 9.7 8.8 0.69 9.7 6.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 KOG99809.1 - 6.6 4.8 18.4 8.4 4.4 12.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 WD40 PF00400.27 KOG99810.1 - 4.2e-46 153.2 25.9 1.1e-10 40.9 0.5 8.0 9 0 0 9 9 9 6 WD domain, G-beta repeat F-box-like PF12937.2 KOG99810.1 - 4.2e-09 35.9 0.1 9e-09 34.9 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 KOG99810.1 - 4.5e-05 22.9 0.6 0.00012 21.5 0.4 1.8 1 0 0 1 1 1 1 F-box domain PQQ_3 PF13570.1 KOG99810.1 - 1.6 9.0 4.2 1.2e+02 3.1 0.0 4.5 4 0 0 4 4 4 0 PQQ-like domain PRANC PF09372.5 KOG99810.1 - 8 6.5 14.3 0.076 12.9 3.2 2.8 3 0 0 3 3 3 0 PRANC domain SMC_N PF02463.14 KOG99811.1 - 4.8e-55 186.1 39.8 1.2e-54 184.9 27.6 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 KOG99811.1 - 4.5e-24 84.7 0.0 1.4e-23 83.1 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 KOG99811.1 - 1.1e-13 52.0 25.2 1.1e-13 52.0 17.5 6.6 2 2 2 4 4 4 1 AAA domain AAA_21 PF13304.1 KOG99811.1 - 4.5e-09 36.6 24.3 7.1e-08 32.7 2.3 5.6 2 2 3 5 5 5 2 AAA domain AAA_29 PF13555.1 KOG99811.1 - 3.1e-08 33.0 0.1 6.3e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Tropomyosin PF00261.15 KOG99811.1 - 0.0018 17.4 20.6 0.0018 17.4 14.3 8.1 3 3 4 7 7 7 2 Tropomyosin Uds1 PF15456.1 KOG99811.1 - 0.0062 16.5 12.5 0.0062 16.5 8.6 7.1 5 1 2 7 7 7 1 Up-regulated During Septation ABC_tran PF00005.22 KOG99811.1 - 0.071 13.4 0.1 0.071 13.4 0.1 6.2 4 3 0 4 4 4 0 ABC transporter Reo_sigmaC PF04582.7 KOG99811.1 - 1.3 8.1 31.9 0.033 13.3 1.3 5.0 3 2 1 5 5 5 0 Reovirus sigma C capsid protein FUSC PF04632.7 KOG99811.1 - 1.8 6.9 1.5 3.4 5.9 1.0 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF3437 PF11919.3 KOG99812.1 - 2.6e-29 100.7 0.0 8.4e-29 99.1 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) Ras PF00071.17 KOG99813.1 - 1.3e-63 213.1 0.4 1.7e-63 212.8 0.2 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG99813.1 - 2e-19 70.2 0.1 2.9e-19 69.6 0.1 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOG99813.1 - 4e-19 68.5 0.1 4.9e-19 68.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 KOG99813.1 - 1.1e-07 31.2 0.2 1.4e-07 30.9 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 KOG99813.1 - 1.7e-07 30.6 0.1 1.9e-07 30.4 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOG99813.1 - 4.7e-06 26.1 0.5 5.6e-05 22.6 0.3 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOG99813.1 - 8.6e-06 25.7 0.2 1.4e-05 25.0 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOG99813.1 - 0.0022 17.3 0.3 0.031 13.5 0.2 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.1 KOG99813.1 - 0.003 17.5 0.2 0.011 15.7 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 KOG99813.1 - 0.0031 17.6 0.1 0.0087 16.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 KOG99813.1 - 0.011 14.9 0.1 0.024 13.8 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF258 MCM PF00493.18 KOG99813.1 - 0.023 13.5 0.0 0.039 12.7 0.0 1.3 1 0 0 1 1 1 0 MCM2/3/5 family AAA_29 PF13555.1 KOG99813.1 - 0.032 13.7 1.7 0.097 12.2 0.4 2.3 2 1 1 3 3 3 0 P-loop containing region of AAA domain AAA PF00004.24 KOG99813.1 - 0.045 13.9 0.0 0.64 10.2 0.0 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.15 KOG99813.1 - 0.062 11.9 0.8 0.99 8.0 0.0 2.4 1 1 1 2 2 2 0 G-protein alpha subunit DUF815 PF05673.8 KOG99813.1 - 0.091 11.6 0.0 0.21 10.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) VTC PF09359.5 KOG99814.1 - 1.3e-99 332.8 0.4 1.3e-99 332.8 0.3 1.7 2 0 0 2 2 2 1 VTC domain SPX PF03105.14 KOG99814.1 - 4.6e-23 82.3 24.9 4.4e-13 49.6 3.5 4.7 3 1 1 4 4 4 3 SPX domain DUF202 PF02656.10 KOG99814.1 - 4e-10 39.7 1.6 8.7e-10 38.6 0.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) MBOAT PF03062.14 KOG99814.1 - 0.00026 20.2 0.5 0.00051 19.2 0.3 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Pex14_N PF04695.8 KOG99814.1 - 0.076 13.0 3.2 0.16 11.9 0.2 2.8 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MutS_V PF00488.16 KOG99815.1 - 4.5e-69 232.4 0.3 1.1e-68 231.2 0.2 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 KOG99815.1 - 7.7e-31 107.4 8.7 8e-31 107.4 3.8 2.4 2 1 0 2 2 2 1 MutS domain III MutS_II PF05188.12 KOG99815.1 - 4.4e-22 78.6 0.2 4.4e-22 78.6 0.2 2.0 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.13 KOG99815.1 - 1.2e-16 60.5 1.0 6.3e-16 58.3 0.7 2.4 1 0 0 1 1 1 1 MutS family domain IV DEAD PF00270.24 KOG99816.1 - 5.4e-39 133.3 0.2 5.5e-38 130.1 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOG99816.1 - 2.2e-21 75.4 0.0 6e-21 74.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 KOG99816.1 - 6.1e-18 64.1 0.0 1.5e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 KOG99816.1 - 0.041 13.7 0.0 0.041 13.7 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit PseudoU_synth_1 PF01416.15 KOG99817.1 - 2.8e-26 91.9 0.0 4.4e-17 62.4 0.0 2.6 2 0 0 2 2 2 2 tRNA pseudouridine synthase Striatin PF08232.7 KOG99817.1 - 0.0036 17.6 1.2 0.0071 16.6 0.8 1.4 1 0 0 1 1 1 1 Striatin family Nic96 PF04097.9 KOG99819.1 - 2e-209 696.7 9.6 2.8e-209 696.2 6.7 1.2 1 0 0 1 1 1 1 Nup93/Nic96 HHH_4 PF14490.1 KOG99819.1 - 0.0006 19.5 0.1 0.095 12.4 0.0 2.9 2 0 0 2 2 2 2 Helix-hairpin-helix containing domain PPI_Ypi1 PF07491.6 KOG99820.1 - 7.6e-22 76.7 12.5 2.5e-21 75.0 8.7 2.0 1 1 0 1 1 1 1 Protein phosphatase inhibitor SR-25 PF10500.4 KOG99820.1 - 0.027 13.9 16.9 0.039 13.4 11.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Herpes_DNAp_acc PF04929.7 KOG99820.1 - 1.1 8.1 8.1 1.4 7.7 5.6 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor CDC45 PF02724.9 KOG99820.1 - 3.5 5.5 15.3 3.8 5.4 10.6 1.1 1 0 0 1 1 1 0 CDC45-like protein JAB PF01398.16 KOG99821.1 - 7.6e-34 115.8 0.2 7.6e-34 115.8 0.1 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 KOG99821.1 - 2.9e-25 88.5 5.2 7.7e-25 87.2 3.6 1.7 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.1 KOG99821.1 - 1.2e-08 34.4 0.0 2.1e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.8 KOG99821.1 - 0.069 12.6 1.0 0.31 10.5 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) UCH PF00443.24 KOG99822.1 - 3.3e-09 36.2 0.4 2.4e-08 33.4 0.3 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 KOG99822.1 - 1.2e-07 31.7 4.5 2.8e-07 30.5 3.1 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Peptidase_M24 PF00557.19 KOG99823.1 - 2e-59 200.6 0.0 2.8e-59 200.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 KOG99823.1 - 1.7e-25 88.9 0.1 7.9e-25 86.7 0.0 2.1 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain DUF515 PF04415.7 KOG99823.1 - 0.061 11.5 0.3 0.098 10.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF4220 PF13968.1 KOG99823.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) AAA_16 PF13191.1 KOG99824.1 - 1e-05 25.6 0.0 2.1e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 KOG99824.1 - 1.3e-05 26.0 0.1 4.6e-05 24.2 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOG99824.1 - 5.1e-05 23.1 0.0 0.0011 18.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 KOG99824.1 - 8e-05 21.8 0.0 0.00018 20.6 0.0 1.5 2 0 0 2 2 1 1 Zeta toxin AAA_5 PF07728.9 KOG99824.1 - 0.00011 21.9 0.0 0.00039 20.1 0.0 2.0 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 KOG99824.1 - 0.00071 19.8 0.0 0.0023 18.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain PRK PF00485.13 KOG99824.1 - 0.00071 19.1 0.1 1.1 8.7 0.0 2.4 2 1 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family KTI12 PF08433.5 KOG99824.1 - 0.0018 17.5 0.0 0.0029 16.8 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 6PF2K PF01591.13 KOG99824.1 - 0.0021 17.1 0.0 0.0037 16.3 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase RNA_helicase PF00910.17 KOG99824.1 - 0.0048 17.0 0.0 0.009 16.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_22 PF13401.1 KOG99824.1 - 0.0061 16.7 0.0 0.015 15.4 0.0 1.7 2 0 0 2 2 1 1 AAA domain MMR_HSR1 PF01926.18 KOG99824.1 - 0.0061 16.4 0.0 0.017 15.0 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA PF00004.24 KOG99824.1 - 0.008 16.3 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MobB PF03205.9 KOG99824.1 - 0.012 15.3 0.0 0.03 14.0 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.1 KOG99824.1 - 0.022 14.6 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 KOG99824.1 - 0.023 13.4 0.0 0.044 12.5 0.0 1.4 1 0 0 1 1 1 0 ArgK protein Sigma54_activat PF00158.21 KOG99824.1 - 0.032 13.6 0.0 0.059 12.8 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain NB-ARC PF00931.17 KOG99824.1 - 0.033 13.0 0.0 0.067 12.0 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.14 KOG99824.1 - 0.036 13.4 0.0 0.081 12.3 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.22 KOG99824.1 - 0.05 13.8 0.0 0.088 13.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Mg_chelatase PF01078.16 KOG99824.1 - 0.055 12.6 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.7 KOG99824.1 - 0.057 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Sigma54_activ_2 PF14532.1 KOG99824.1 - 0.074 13.1 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.1 KOG99824.1 - 0.076 12.5 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 KOG99824.1 - 0.091 12.5 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA_29 PF13555.1 KOG99824.1 - 0.098 12.2 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.10 KOG99824.1 - 0.11 12.1 0.0 0.31 10.7 0.0 1.7 1 0 0 1 1 1 0 NTPase RuvB_N PF05496.7 KOG99824.1 - 0.11 11.4 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus PPV_E1_C PF00519.12 KOG99824.1 - 0.12 10.9 0.0 0.18 10.4 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase ATP-synt_G PF04718.10 KOG99825.1 - 0.15 12.7 5.8 1.3 9.7 0.0 2.6 3 0 0 3 3 3 0 Mitochondrial ATP synthase g subunit FlaC_arch PF05377.6 KOG99825.1 - 0.37 10.7 0.2 0.37 10.7 0.1 2.8 3 2 1 4 4 4 0 Flagella accessory protein C (FlaC) FAM195 PF14799.1 KOG99825.1 - 0.4 10.5 7.1 2.3 8.1 1.5 2.4 2 1 0 2 2 2 0 FAM195 family DUF4407 PF14362.1 KOG99825.1 - 0.9 8.4 7.9 1.1 8.1 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hexokinase_2 PF03727.11 KOG99825.1 - 1.9 7.6 5.2 0.27 10.3 0.7 1.7 2 0 0 2 2 2 0 Hexokinase SIR2 PF02146.12 KOG99825.1 - 4.4 6.9 8.2 1.8 8.2 1.8 2.3 2 1 0 2 2 2 0 Sir2 family Plasmodium_HRP PF05403.6 KOG99826.1 - 3.3e-05 23.5 9.0 3.3e-05 23.5 6.2 2.2 1 1 1 2 2 2 1 Plasmodium histidine-rich protein (HRPII/III) Glutaredoxin PF00462.19 KOG99827.1 - 0.0085 16.0 0.0 0.029 14.3 0.0 2.0 1 0 0 1 1 1 1 Glutaredoxin SH3BGR PF04908.10 KOG99827.1 - 0.027 14.3 0.1 0.15 12.0 0.0 2.3 2 1 1 3 3 3 0 SH3-binding, glutamic acid-rich protein Pex14_N PF04695.8 KOG99827.1 - 0.06 13.3 0.6 0.06 13.3 0.4 2.2 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Glycogen_syn PF05693.8 KOG99828.1 - 0 1138.4 0.0 0 1138.2 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.15 KOG99828.1 - 1.4e-10 40.8 0.0 1.1e-07 31.4 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 KOG99828.1 - 0.00025 21.2 0.1 0.00045 20.3 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Pkinase PF00069.20 KOG99829.1 - 1.4e-71 240.6 0.0 2.4e-71 239.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOG99829.1 - 3.5e-38 131.1 0.0 5.1e-38 130.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOG99829.1 - 0.00051 19.0 0.0 0.24 10.2 0.0 2.4 2 0 0 2 2 2 2 Kinase-like YrbL-PhoP_reg PF10707.4 KOG99829.1 - 0.021 14.1 0.0 0.06 12.6 0.0 1.7 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL WHIM1 PF15612.1 KOG99830.1 - 9.9e-05 22.0 0.0 0.00031 20.5 0.0 1.9 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 NOA36 PF06524.7 KOG99830.1 - 1.1 8.5 14.3 2.3 7.3 9.9 1.5 1 0 0 1 1 1 0 NOA36 protein SUR7 PF06687.7 KOG99831.1 - 1.7e-17 63.6 20.5 3e-17 62.9 14.2 1.4 1 0 0 1 1 1 1 SUR7/PalI family TspO_MBR PF03073.10 KOG99831.1 - 0.64 9.5 9.4 3.4 7.1 6.5 2.0 1 1 0 1 1 1 0 TspO/MBR family DUF1690 PF07956.6 KOG99832.1 - 7.4e-56 188.0 10.6 8.6e-56 187.8 7.3 1.0 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) UCH PF00443.24 KOG99833.1 - 6e-51 173.1 7.8 7.8e-51 172.7 5.4 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOG99833.1 - 1.8e-18 66.9 17.1 3.4e-18 66.1 11.9 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 KOG99833.1 - 4.9e-05 22.6 0.6 0.00036 19.8 0.0 2.5 2 0 0 2 2 2 1 Ubiquitin family Glyco_hydro_31 PF01055.21 KOG99833.1 - 0.021 13.6 0.2 0.029 13.2 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 31 ABC_tran PF00005.22 KOG99834.1 - 1e-47 161.8 0.2 2.7e-23 82.7 0.0 3.1 2 0 0 2 2 2 2 ABC transporter ABC_tran_2 PF12848.2 KOG99834.1 - 9.4e-19 67.0 9.3 9.4e-19 67.0 6.4 2.3 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 KOG99834.1 - 1.2e-16 61.5 15.0 5.3e-06 26.5 0.0 5.4 3 2 2 5 5 5 3 AAA domain SMC_N PF02463.14 KOG99834.1 - 2.7e-10 39.8 0.0 0.0023 17.1 0.0 3.5 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 KOG99834.1 - 7.5e-09 36.4 0.6 0.00064 20.5 0.0 3.3 4 0 0 4 4 2 2 AAA domain AAA_28 PF13521.1 KOG99834.1 - 1.3e-07 31.7 0.1 0.022 14.7 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 KOG99834.1 - 7.5e-07 28.5 0.0 0.063 12.8 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 KOG99834.1 - 9.4e-07 29.0 0.4 0.15 12.2 0.1 3.8 3 1 0 3 3 3 2 AAA domain NACHT PF05729.7 KOG99834.1 - 1.3e-06 28.1 0.5 0.0086 15.7 0.0 2.8 2 1 0 3 3 2 2 NACHT domain DUF258 PF03193.11 KOG99834.1 - 1.6e-06 27.4 0.0 0.036 13.2 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 KOG99834.1 - 3.9e-06 26.9 0.1 0.11 12.5 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain Miro PF08477.8 KOG99834.1 - 5e-06 27.0 0.0 0.16 12.4 0.0 2.9 2 0 0 2 2 2 2 Miro-like protein AAA_15 PF13175.1 KOG99834.1 - 5.9e-06 25.5 20.7 0.013 14.6 0.0 5.7 4 1 1 5 5 5 2 AAA ATPase domain AAA_14 PF13173.1 KOG99834.1 - 1e-05 25.4 0.0 0.15 11.9 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.1 KOG99834.1 - 1.2e-05 25.6 10.0 0.15 12.3 0.0 4.8 5 1 0 5 5 5 2 AAA domain AAA_33 PF13671.1 KOG99834.1 - 2.6e-05 24.1 0.0 0.075 12.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain MobB PF03205.9 KOG99834.1 - 3.6e-05 23.4 0.1 0.17 11.5 0.0 2.8 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.24 KOG99834.1 - 4.9e-05 23.5 0.0 0.17 12.1 0.0 3.4 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) ATP-synt_ab PF00006.20 KOG99834.1 - 5.6e-05 22.7 0.0 0.027 13.9 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain MMR_HSR1 PF01926.18 KOG99834.1 - 6.8e-05 22.7 0.0 0.12 12.3 0.0 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 KOG99834.1 - 9e-05 21.9 0.1 0.18 11.3 0.1 2.8 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_10 PF12846.2 KOG99834.1 - 0.00013 21.5 0.0 1.7 8.0 0.0 3.3 3 0 0 3 3 3 2 AAA-like domain RNA_helicase PF00910.17 KOG99834.1 - 0.00031 20.8 1.0 0.33 11.1 0.0 3.3 4 0 0 4 4 2 1 RNA helicase SbcCD_C PF13558.1 KOG99834.1 - 0.00034 20.4 0.1 1.1 9.2 0.0 3.3 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Arch_ATPase PF01637.13 KOG99834.1 - 0.00072 19.3 2.3 0.48 10.0 0.0 3.1 3 0 0 3 3 2 2 Archaeal ATPase ArgK PF03308.11 KOG99834.1 - 0.0013 17.5 0.0 0.17 10.6 0.0 2.5 2 0 0 2 2 2 1 ArgK protein NB-ARC PF00931.17 KOG99834.1 - 0.0015 17.4 0.0 1.1 8.0 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain AAA_5 PF07728.9 KOG99834.1 - 0.0017 18.0 0.0 3.1 7.5 0.0 2.8 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) NTPase_1 PF03266.10 KOG99834.1 - 0.0019 17.9 0.0 0.64 9.7 0.0 2.6 2 0 0 2 2 2 1 NTPase AAA_25 PF13481.1 KOG99834.1 - 0.0078 15.6 0.0 4.7 6.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 KOG99834.1 - 0.0092 15.8 6.5 0.089 12.6 0.2 3.6 2 1 1 3 3 3 1 Dynamin family Zeta_toxin PF06414.7 KOG99834.1 - 0.01 14.9 0.0 1.6 7.8 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.1 KOG99834.1 - 0.014 15.7 0.0 0.25 11.6 0.0 5.2 4 1 0 5 5 4 0 AAA domain Pox_A32 PF04665.7 KOG99834.1 - 0.015 14.6 1.6 0.16 11.2 0.0 2.7 3 0 0 3 3 3 0 Poxvirus A32 protein T2SE PF00437.15 KOG99834.1 - 0.02 13.8 0.0 0.31 9.8 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein cobW PF02492.14 KOG99834.1 - 0.02 14.3 0.2 2.3 7.6 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.13 KOG99834.1 - 0.026 13.7 0.0 6.4 6.0 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B SRP54 PF00448.17 KOG99834.1 - 0.033 13.6 0.0 2 7.8 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain FtsK_SpoIIIE PF01580.13 KOG99834.1 - 0.067 12.6 0.6 5.7 6.3 0.0 2.8 2 1 1 3 3 3 0 FtsK/SpoIIIE family UPF0079 PF02367.12 KOG99834.1 - 0.073 12.7 0.0 1.1 8.9 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Viral_helicase1 PF01443.13 KOG99834.1 - 0.093 12.2 0.0 2.8 7.3 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Troponin-I_N PF11636.3 KOG99835.1 - 0.66 9.7 17.7 0.23 11.1 0.7 3.5 3 0 0 3 3 3 0 Troponin I residues 1-32 Peptidase_M28 PF04389.12 KOG99836.1 - 2.4e-41 141.4 0.1 3.5e-41 140.8 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M28 PIP5K PF01504.13 KOG99837.1 - 1.1e-64 217.9 2.7 1.1e-64 217.9 1.9 2.3 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.19 KOG99837.1 - 1.2e-23 83.5 0.1 1.2e-23 83.5 0.1 1.7 2 0 0 2 2 2 1 TCP-1/cpn60 chaperonin family FYVE PF01363.16 KOG99837.1 - 2e-15 56.4 15.0 6e-15 54.9 10.4 1.9 1 0 0 1 1 1 1 FYVE zinc finger DUF3391 PF11871.3 KOG99837.1 - 6.3 7.0 7.9 0.41 10.8 0.5 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3391) WD40 PF00400.27 KOG99838.1 - 6.8e-08 32.0 0.0 0.011 15.5 0.0 2.9 3 0 0 3 3 3 2 WD domain, G-beta repeat CNH PF00780.17 KOG99838.1 - 0.032 13.6 0.0 0.14 11.5 0.0 2.0 2 1 0 2 2 2 0 CNH domain Arrestin_C PF02752.17 KOG99839.1 - 1.8e-23 83.1 0.1 1e-22 80.6 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 KOG99839.1 - 2e-09 37.4 0.0 5.1e-08 32.8 0.0 2.3 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.2 KOG99839.1 - 0.00062 19.3 0.1 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 Arrestin_N terminal like RRM_1 PF00076.17 KOG99840.1 - 1.6e-50 168.5 11.5 7.8e-20 70.2 0.1 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOG99840.1 - 6.4e-32 109.3 0.8 4.9e-09 36.0 0.0 4.4 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG99840.1 - 7.7e-23 80.1 3.4 5e-08 32.6 0.3 4.4 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 KOG99840.1 - 4.5e-07 29.5 1.7 0.3 10.8 0.0 4.9 2 2 2 4 4 4 3 Limkain b1 RRM_3 PF08777.6 KOG99840.1 - 7e-06 25.8 5.4 2 8.2 0.1 4.8 4 2 0 4 4 4 3 RNA binding motif Nup35_RRM_2 PF14605.1 KOG99840.1 - 1.3e-05 24.8 0.1 0.00048 19.8 0.0 3.2 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif DUF500 PF04366.7 KOG99841.1 - 7.6e-45 151.4 0.1 1.3e-44 150.6 0.1 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF500) SH3_1 PF00018.23 KOG99841.1 - 3.6e-17 61.4 0.0 7.7e-17 60.4 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOG99841.1 - 2.9e-14 52.3 0.1 6.8e-14 51.1 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOG99841.1 - 3.2e-12 45.7 0.0 6.7e-12 44.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PHP PF02811.14 KOG99842.1 - 1.9e-24 86.4 0.0 3.9e-24 85.3 0.0 1.5 1 1 0 1 1 1 1 PHP domain Acetyltransf_13 PF13880.1 KOG99843.1 - 4.1e-21 74.4 0.0 9.8e-21 73.2 0.0 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.1 KOG99843.1 - 4.2e-10 39.0 0.3 7e-10 38.3 0.2 1.4 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO ECH PF00378.15 KOG99843.1 - 0.09 11.8 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase family FAINT PF04385.10 KOG99843.1 - 0.12 12.2 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function, DUF529 DSPn PF14671.1 KOG99844.1 - 1.8e-50 170.5 0.0 4.7e-50 169.2 0.0 1.7 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.15 KOG99844.1 - 1e-25 89.8 0.0 7.3e-25 87.0 0.0 2.2 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOG99844.1 - 0.00015 21.1 0.0 0.00042 19.7 0.0 1.7 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.7 KOG99844.1 - 0.00072 19.0 0.6 0.0015 17.9 0.1 1.7 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.1 KOG99844.1 - 0.0033 17.4 0.0 0.0082 16.1 0.0 1.7 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 KOG99844.1 - 0.082 13.1 0.4 0.32 11.2 0.2 1.9 1 1 0 1 1 1 0 Tyrosine phosphatase family ORC6 PF05460.8 KOG99844.1 - 0.47 9.5 8.8 0.68 8.9 6.1 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) FAD_binding_1 PF00667.15 KOG99846.1 - 3.9e-72 242.2 0.2 1.4e-71 240.4 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.16 KOG99846.1 - 5.4e-10 39.8 0.1 3.3e-09 37.2 0.0 2.4 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 KOG99846.1 - 0.089 12.9 0.0 0.44 10.7 0.0 2.1 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain SMC_N PF02463.14 KOG99847.1 - 1.2e-70 237.1 11.4 2.9e-69 232.6 7.9 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 KOG99847.1 - 3.6e-25 88.2 0.3 2.3e-24 85.6 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 KOG99847.1 - 5e-10 39.8 10.0 3.6e-06 27.1 0.2 4.9 3 2 1 4 4 4 2 AAA domain AAA_23 PF13476.1 KOG99847.1 - 1.5e-05 25.4 45.6 1.5e-05 25.4 31.6 6.8 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.1 KOG99847.1 - 2e-05 24.0 0.1 4.6e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain GAS PF13851.1 KOG99847.1 - 4.2e-05 22.8 39.7 0.00012 21.3 19.4 7.9 3 2 5 8 8 8 3 Growth-arrest specific micro-tubule binding Tropomyosin PF00261.15 KOG99847.1 - 0.0028 16.7 25.0 0.0028 16.7 17.3 7.3 2 2 2 5 5 5 1 Tropomyosin Reo_sigmaC PF04582.7 KOG99847.1 - 0.012 14.7 40.9 0.0068 15.6 4.0 5.7 2 2 3 6 6 6 0 Reovirus sigma C capsid protein ABC_tran PF00005.22 KOG99847.1 - 0.48 10.7 0.0 0.48 10.7 0.0 6.2 3 2 0 3 3 3 0 ABC transporter Ribosomal_L2_C PF03947.13 KOG99848.1 - 9.6e-08 31.8 1.5 1.3e-07 31.5 1.0 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain RRM_6 PF14259.1 KOG99849.1 - 9e-15 54.4 0.0 1.5e-10 40.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOG99849.1 - 1.2e-14 53.7 0.0 2.7e-09 36.5 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOG99849.1 - 0.0013 18.5 0.0 0.0031 17.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L29e PF01779.12 KOG99850.1 - 1.8e-24 85.2 8.8 2.4e-24 84.8 6.1 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family UCR_hinge PF02320.11 KOG99851.1 - 3.5e-21 74.8 4.7 5.8e-21 74.2 3.3 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Sigma70_ner PF04546.8 KOG99851.1 - 7.6e-05 22.4 15.3 9e-05 22.1 10.6 1.2 1 0 0 1 1 1 1 Sigma-70, non-essential region RAB3GAP2_C PF14656.1 KOG99851.1 - 0.0024 16.0 2.1 0.0026 15.9 1.4 1.1 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit C-terminus DUF506 PF04720.7 KOG99851.1 - 0.0058 16.2 8.9 0.0071 16.0 6.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF506) Nop14 PF04147.7 KOG99851.1 - 0.0076 14.2 22.4 0.0077 14.2 15.5 1.0 1 0 0 1 1 1 1 Nop14-like family RNA_pol_Rpc4 PF05132.9 KOG99851.1 - 0.087 12.8 4.6 0.14 12.1 3.2 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Neisseria_TspB PF05616.8 KOG99851.1 - 0.093 11.0 2.9 0.1 10.9 2.0 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein RRN3 PF05327.6 KOG99851.1 - 0.17 9.9 12.2 0.17 9.9 8.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Daxx PF03344.10 KOG99851.1 - 0.17 10.3 24.4 0.2 10.1 16.9 1.0 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 KOG99851.1 - 0.19 9.7 16.8 0.21 9.5 11.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3530 PF12048.3 KOG99851.1 - 0.31 9.9 4.5 0.37 9.7 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Cwf_Cwc_15 PF04889.7 KOG99851.1 - 0.33 10.6 21.8 0.4 10.3 15.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pro_CA PF00484.14 KOG99851.1 - 0.33 10.9 1.9 0.46 10.4 1.3 1.4 1 0 0 1 1 1 0 Carbonic anhydrase Vfa1 PF08432.5 KOG99851.1 - 0.58 10.1 12.2 0.73 9.8 8.5 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Sigma_reg_C PF13791.1 KOG99851.1 - 0.59 10.1 6.7 0.72 9.8 4.6 1.2 1 0 0 1 1 1 0 Sigma factor regulator C-terminal FLO_LFY PF01698.11 KOG99851.1 - 1.9 7.2 10.7 2.5 6.8 7.4 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein CENP-T PF15511.1 KOG99851.1 - 1.9 7.6 17.4 2.2 7.4 12.1 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T tRNA-Thr_ED PF08915.6 KOG99851.1 - 2 8.3 4.4 1.1 9.2 0.8 2.0 1 1 1 2 2 2 0 Archaea-specific editing domain of threonyl-tRNA synthetase Mpp10 PF04006.7 KOG99851.1 - 2.6 6.3 25.4 2.9 6.1 17.6 1.0 1 0 0 1 1 1 0 Mpp10 protein Ycf1 PF05758.7 KOG99851.1 - 2.6 5.6 10.6 2.7 5.5 7.3 1.0 1 0 0 1 1 1 0 Ycf1 SAPS PF04499.10 KOG99851.1 - 3.1 6.3 7.3 3.2 6.2 5.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF1510 PF07423.6 KOG99851.1 - 4.9 6.4 19.6 5.6 6.2 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) NOA36 PF06524.7 KOG99851.1 - 5.1 6.2 18.5 7.7 5.6 12.8 1.4 1 0 0 1 1 1 0 NOA36 protein CobT PF06213.7 KOG99851.1 - 5.5 6.0 24.5 7.3 5.6 17.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT BUD22 PF09073.5 KOG99851.1 - 6.8 5.6 21.1 7.1 5.5 14.6 1.1 1 0 0 1 1 1 0 BUD22 Rep_4 PF05797.6 KOG99851.1 - 9.4 4.8 8.2 11 4.5 5.7 1.1 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) NOA36 PF06524.7 KOG99852.1 - 4.9 6.3 7.0 6.7 5.8 4.8 1.2 1 0 0 1 1 1 0 NOA36 protein APC_CDC26 PF10471.4 KOG99854.1 - 4.3e-12 46.5 7.4 9.5e-12 45.4 5.1 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex APC subunit 1 PBP1_TM PF14812.1 KOG99854.1 - 0.38 11.1 7.6 0.33 11.2 4.5 1.5 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2457 PF10446.4 KOG99854.1 - 3.1 6.4 13.7 3.5 6.2 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF506 PF04720.7 KOG99854.1 - 6.3 6.3 7.0 8.7 5.9 4.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF506) DUF3245 PF11595.3 KOG99854.1 - 9.7 6.4 10.9 6.8 6.9 6.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3245) SWIRM PF04433.12 KOG99855.1 - 7.9e-32 109.2 0.2 1.7e-31 108.1 0.1 1.6 1 0 0 1 1 1 1 SWIRM domain ZZ PF00569.12 KOG99855.1 - 1.4e-17 62.9 4.1 2.3e-17 62.2 2.8 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.26 KOG99855.1 - 1.4e-06 28.2 0.2 2.9e-06 27.2 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOG99855.1 - 5.4e-06 26.4 0.0 3.1e-05 23.9 0.0 2.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Elf1 PF05129.8 KOG99855.1 - 0.0047 16.5 0.3 0.015 14.9 0.2 1.8 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like SNF2_N PF00176.18 KOG99856.1 - 5.3e-73 245.4 0.1 5.3e-73 245.4 0.1 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOG99856.1 - 3.7e-15 55.5 0.0 1.4e-14 53.7 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOG99856.1 - 2.5e-07 30.3 0.0 5.4e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase UPF0515 PF15135.1 KOG99856.1 - 0.58 9.1 3.2 1.2 8.0 2.2 1.6 1 0 0 1 1 1 0 Uncharacterised protein UPF0515 SAPS PF04499.10 KOG99858.1 - 6e-171 569.2 10.8 6e-171 569.2 7.5 4.0 4 0 0 4 4 4 1 SIT4 phosphatase-associated protein DnaJ PF00226.26 KOG99859.1 - 5e-14 51.7 3.0 1e-13 50.8 2.1 1.5 1 0 0 1 1 1 1 DnaJ domain RNA_pol_Rbc25 PF08292.7 KOG99859.1 - 0.002 18.2 0.3 0.0039 17.3 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 Adaptin_binding PF10199.4 KOG99861.1 - 2.5e-07 31.0 2.6 0.014 15.6 0.3 2.3 1 1 1 2 2 2 2 Alpha and gamma adaptin binding protein p34 Peptidase_M20 PF01546.23 KOG99862.1 - 4.3e-28 98.1 0.0 6.6e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 KOG99862.1 - 8e-13 48.1 0.0 1.3e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain DUF848 PF05852.6 KOG99862.1 - 0.11 12.3 0.1 0.44 10.3 0.0 1.9 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Mito_carr PF00153.22 KOG99863.1 - 7.3e-38 128.1 7.0 2.1e-18 65.8 0.5 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein PAZ_siRNAbind PF12212.3 KOG99864.1 - 0.095 12.3 0.2 6.7 6.4 0.0 2.6 2 0 0 2 2 2 0 Piwi/Argonaute/Zwille siRNA-binding domain Ribosomal_60s PF00428.14 KOG99864.1 - 0.25 11.7 11.4 0.61 10.5 7.9 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Herpes_pp85 PF04637.7 KOG99864.1 - 0.26 9.5 4.4 0.082 11.1 1.0 1.6 2 0 0 2 2 2 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) SRP14 PF02290.10 KOG99864.1 - 0.28 11.1 0.1 0.28 11.1 0.1 2.2 2 1 1 3 3 3 0 Signal recognition particle 14kD protein Nucleoplasmin PF03066.10 KOG99864.1 - 0.34 10.4 10.9 0.82 9.1 7.6 1.7 1 0 0 1 1 1 0 Nucleoplasmin Radial_spoke PF04712.7 KOG99864.1 - 0.68 8.6 14.8 0.3 9.7 4.5 2.2 2 0 0 2 2 2 0 Radial spokehead-like protein QRPTase_C PF01729.14 KOG99865.1 - 1.9e-58 196.7 0.0 2.3e-58 196.4 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.11 KOG99865.1 - 2e-23 82.0 0.0 4.4e-23 80.9 0.0 1.6 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain DUF155 PF02582.9 KOG99866.1 - 6.1e-59 198.8 0.2 1.1e-58 198.0 0.2 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 DUF2638 PF10937.3 KOG99867.1 - 1.6e-31 109.6 0.1 1.8e-31 109.4 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2638) E_Pc_C PF06752.7 KOG99867.1 - 0.016 14.6 0.0 0.018 14.5 0.0 1.1 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus Proteasome PF00227.21 KOG99868.1 - 5.1e-24 84.6 0.0 6.5e-24 84.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Adap_comp_sub PF00928.16 KOG99869.1 - 1e-09 37.9 0.0 1.6e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 KOG99869.1 - 1.2e-08 34.7 2.3 2.4e-08 33.8 1.6 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.4 KOG99869.1 - 0.0048 16.1 0.0 0.014 14.5 0.0 1.7 1 1 0 1 1 1 1 Muniscin C-terminal mu homology domain CDC37_N PF03234.9 KOG99869.1 - 0.0067 16.7 2.4 0.061 13.6 0.1 2.3 2 0 0 2 2 2 1 Cdc37 N terminal kinase binding SAC3_GANP PF03399.11 KOG99870.1 - 3.5e-30 105.0 3.1 4.7e-30 104.6 2.1 1.2 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 KOG99870.1 - 3.9e-20 72.0 3.7 3.9e-20 72.0 2.5 1.5 2 0 0 2 2 2 1 COP9 signalosome, subunit CSN8 Hexokinase_2 PF03727.11 KOG99871.1 - 2.4e-97 324.9 0.0 4.3e-97 324.0 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KOG99871.1 - 7.6e-88 293.2 0.1 1.1e-87 292.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase FGGY_N PF00370.16 KOG99871.1 - 0.0024 17.2 0.0 0.0043 16.4 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Apolipoprotein PF01442.13 KOG99871.1 - 0.08 12.4 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Flocculin_t3 PF13928.1 KOG99873.1 - 3.5e-10 39.8 19.1 3.5e-10 39.8 13.3 5.5 4 3 0 4 4 4 1 Flocculin type 3 repeat Flocculin PF00624.13 KOG99873.1 - 5.1e-09 35.8 22.6 5.1e-09 35.8 15.7 6.7 6 3 1 7 7 7 1 Flocculin repeat FMN_bind_2 PF04299.7 KOG99875.1 - 1.5e-54 183.9 0.0 2.3e-54 183.3 0.0 1.3 1 0 0 1 1 1 1 Putative FMN-binding domain Cys_Met_Meta_PP PF01053.15 KOG99876.1 - 5e-89 298.2 0.0 6e-89 298.0 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 KOG99876.1 - 6.9e-07 28.5 0.0 1e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 KOG99876.1 - 0.00017 20.4 0.0 0.00024 19.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 KOG99876.1 - 0.00048 19.3 0.0 0.0013 17.9 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 KOG99876.1 - 0.0012 17.9 0.0 0.0026 16.8 0.0 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Glyco_hydro_28 PF00295.12 KOG99877.1 - 9.2e-70 235.1 14.9 1.1e-69 234.9 10.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.1 KOG99877.1 - 0.0099 15.6 23.8 0.016 14.9 14.0 2.3 1 1 1 2 2 2 2 Right handed beta helix region YjbE PF11106.3 KOG99877.1 - 4.2 7.4 9.2 4 7.4 3.3 2.4 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE DUP PF00674.13 KOG99878.1 - 2.2e-45 153.0 16.8 3.6e-26 91.2 4.3 2.2 2 0 0 2 2 2 2 DUP family Aldo_ket_red PF00248.16 KOG99879.1 - 5.2e-45 153.4 0.0 5.8e-45 153.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family S-methyl_trans PF02574.11 KOG99880.1 - 2.8e-90 302.7 0.0 3.2e-90 302.5 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Kelch_1 PF01344.20 KOG99880.1 - 0.0048 16.4 0.2 0.035 13.6 0.0 2.2 2 0 0 2 2 2 1 Kelch motif AA_permease PF00324.16 KOG99881.1 - 6.2e-105 351.2 36.9 7.1e-105 351.0 25.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG99881.1 - 6.2e-36 123.8 38.7 8e-36 123.4 26.8 1.2 1 0 0 1 1 1 1 Amino acid permease FAD_binding_7 PF03441.9 KOG99882.1 - 9.6e-79 264.4 0.9 1.6e-78 263.7 0.1 1.8 2 1 0 2 2 2 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 KOG99882.1 - 4.8e-29 101.2 0.2 9.2e-29 100.3 0.1 1.5 1 0 0 1 1 1 1 DNA photolyase Acetyltransf_1 PF00583.19 KOG99883.1 - 2.4e-13 49.9 0.0 3.4e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOG99883.1 - 0.00019 21.4 0.1 0.00033 20.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KOG99883.1 - 0.00036 20.7 0.2 0.00043 20.4 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOG99883.1 - 0.00041 20.0 0.0 0.00058 19.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.1 KOG99883.1 - 0.0017 18.1 0.0 0.0032 17.3 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_8 PF13523.1 KOG99883.1 - 0.0033 17.3 0.0 0.0047 16.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 KOG99883.1 - 0.004 16.7 0.1 0.054 13.0 0.0 2.1 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOG99883.1 - 0.086 12.9 0.0 0.095 12.8 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain MFS_1 PF07690.11 KOG99884.1 - 1.5e-11 43.6 47.3 1.2e-08 34.1 31.9 2.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOG99884.1 - 2.8e-05 22.8 8.8 2.8e-05 22.8 6.1 2.8 3 0 0 3 3 3 2 Sugar (and other) transporter FUSC PF04632.7 KOG99884.1 - 0.35 9.2 3.3 0.57 8.5 2.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Aa_trans PF01490.13 KOG99885.1 - 8.1e-97 324.2 33.3 9.2e-97 324.0 23.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease PF00324.16 KOG99886.1 - 3.9e-140 467.3 52.8 4.9e-140 467.0 36.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOG99886.1 - 2.6e-27 95.4 56.9 3.4e-27 95.0 39.4 1.1 1 0 0 1 1 1 1 Amino acid permease NPR2 PF06218.6 KOG99887.1 - 1.5e-171 570.8 6.3 1.5e-171 570.8 4.4 1.8 2 0 0 2 2 2 1 Nitrogen permease regulator 2 Kinesin PF00225.18 KOG99888.1 - 3.4e-96 321.8 8.7 9.9e-64 215.1 3.3 4.0 3 2 0 3 3 3 2 Kinesin motor domain AIP3 PF03915.8 KOG99888.1 - 0.0036 16.2 16.0 0.0036 16.2 11.1 3.9 2 1 2 4 4 4 1 Actin interacting protein 3 DUF2730 PF10805.3 KOG99888.1 - 0.35 10.6 9.5 0.059 13.0 0.5 3.3 2 1 0 3 3 3 0 Protein of unknown function (DUF2730) Peptidase_S8 PF00082.17 KOG99889.1 - 5.8e-57 192.9 4.7 5.8e-57 192.9 3.3 1.5 2 0 0 2 2 2 1 Subtilase family Inhibitor_I9 PF05922.11 KOG99889.1 - 1.8e-13 50.8 0.2 1.8e-13 50.8 0.2 2.5 3 0 0 3 3 3 1 Peptidase inhibitor I9 Mitochondr_Som1 PF11093.3 KOG99890.1 - 2.8e-25 87.9 0.0 3.2e-25 87.7 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial export protein Som1 PGM_PMM_I PF02878.11 KOG99891.1 - 5.6e-16 58.2 0.1 2.6e-08 33.4 0.0 2.7 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 KOG99891.1 - 1.8e-13 50.7 0.0 5.5e-13 49.1 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 KOG99891.1 - 1.5e-08 34.5 0.0 3.9e-08 33.1 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Peptidase_M26_C PF07580.9 KOG99891.1 - 0.094 11.0 0.1 0.16 10.2 0.1 1.3 1 0 0 1 1 1 0 M26 IgA1-specific Metallo-endopeptidase C-terminal region DUF4250 PF14056.1 KOG99892.1 - 0.48 10.1 2.2 18 5.1 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4250) CAF1C_H4-bd PF12265.3 KOG99893.1 - 5e-24 84.0 0.1 1.2e-23 82.7 0.1 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 KOG99893.1 - 8.3e-21 73.0 3.0 4e-06 26.5 0.0 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat CNH PF00780.17 KOG99893.1 - 0.0034 16.8 0.0 0.015 14.7 0.0 1.8 2 0 0 2 2 2 1 CNH domain DNA_pol_phi PF04931.8 KOG99894.1 - 4.4e-256 851.5 25.5 6.7e-256 850.9 17.7 1.3 1 0 0 1 1 1 1 DNA polymerase phi Ribosomal_L11_N PF03946.9 KOG99895.1 - 4.3e-17 61.3 0.2 8.6e-17 60.3 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 KOG99895.1 - 3.3e-11 43.1 0.8 6.7e-11 42.1 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain Mak10 PF04112.8 KOG99896.1 - 4.6e-45 152.8 0.0 1.3e-44 151.3 0.0 1.8 2 0 0 2 2 2 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase DUF2489 PF10675.4 KOG99896.1 - 0.0061 16.2 0.8 0.02 14.5 0.6 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2489) AFG1_ATPase PF03969.11 KOG99897.1 - 3.9e-74 249.6 0.0 6.9e-67 225.7 0.0 4.0 2 1 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.1 KOG99897.1 - 1.7e-05 24.8 0.2 0.013 15.5 0.0 2.6 1 1 0 2 2 2 2 AAA ATPase domain AAA PF00004.24 KOG99897.1 - 0.00077 19.6 0.0 0.0016 18.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 KOG99897.1 - 0.0076 15.9 0.0 0.016 14.8 0.0 1.6 1 0 0 1 1 1 1 Archaeal ATPase Bac_DnaA PF00308.13 KOG99897.1 - 0.0098 15.5 0.1 0.021 14.5 0.1 1.6 1 1 0 1 1 1 1 Bacterial dnaA protein AAA_22 PF13401.1 KOG99897.1 - 0.02 15.0 0.0 0.049 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOG99897.1 - 0.023 14.8 0.0 0.078 13.1 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.9 KOG99897.1 - 0.029 14.0 0.0 0.073 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.7 KOG99897.1 - 0.14 11.7 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Mg_chelatase PF01078.16 KOG99897.1 - 0.18 10.9 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATP-synt_D PF01813.12 KOG99898.1 - 5e-63 212.2 4.7 6.3e-63 211.8 3.3 1.1 1 0 0 1 1 1 1 ATP synthase subunit D NARP1 PF12569.3 KOG99898.1 - 0.02 13.6 5.4 0.037 12.8 3.7 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RICH PF05062.7 KOG99898.1 - 0.11 12.6 4.3 0.13 12.4 1.0 2.3 2 0 0 2 2 2 0 RICH domain Ribosomal_L2_C PF03947.13 KOG99899.1 - 1.2e-50 170.6 1.1 2.4e-50 169.6 0.8 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 KOG99899.1 - 1.2e-27 95.6 0.1 3e-27 94.3 0.1 1.7 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain SRP1_TIP1 PF00660.12 KOG99900.1 - 2.2e-32 110.9 0.2 2.7e-32 110.6 0.1 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family Sedlin_N PF04628.8 KOG99901.1 - 2e-11 43.8 0.0 2.4e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region FAD_binding_2 PF00890.19 KOG99902.1 - 4.6e-75 253.0 0.0 5.2e-75 252.8 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 KOG99902.1 - 4.3e-09 35.7 0.0 3.4e-06 26.1 0.0 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOG99902.1 - 1.3e-08 35.0 0.4 0.00022 21.1 0.1 3.0 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KOG99902.1 - 6e-08 32.5 0.0 2.9e-07 30.3 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 KOG99902.1 - 2.9e-07 29.8 0.0 8e-07 28.4 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.1 KOG99902.1 - 4e-06 27.0 0.0 7.7e-05 22.8 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 KOG99902.1 - 2.5e-05 23.4 2.0 0.0019 17.3 0.3 2.4 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.7 KOG99902.1 - 5.8e-05 22.1 0.2 0.059 12.2 0.1 3.0 3 0 0 3 3 3 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 KOG99902.1 - 0.00012 21.8 0.0 0.00075 19.3 0.0 2.1 1 1 0 1 1 1 1 FAD-NAD(P)-binding HI0933_like PF03486.9 KOG99902.1 - 0.00031 19.3 4.7 0.037 12.4 0.1 3.4 4 0 0 4 4 4 2 HI0933-like protein Amino_oxidase PF01593.19 KOG99902.1 - 0.0019 17.3 0.0 0.11 11.5 0.0 2.4 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.22 KOG99902.1 - 0.002 18.5 0.4 0.22 11.9 0.1 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOG99902.1 - 0.027 13.5 0.3 0.15 11.0 0.2 2.0 1 1 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.13 KOG99902.1 - 0.034 13.8 0.0 0.069 12.7 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.17 KOG99902.1 - 0.19 10.5 1.4 0.78 8.5 0.0 2.4 3 0 0 3 3 3 0 Glucose inhibited division protein A Beta_elim_lyase PF01212.16 KOG99903.1 - 2.5e-77 259.8 0.0 3e-77 259.6 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 KOG99903.1 - 0.0024 16.8 0.0 0.0033 16.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II YL1_C PF08265.6 KOG99904.1 - 4.2e-13 48.6 0.3 4.2e-13 48.6 0.2 1.9 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain DUF1043 PF06295.7 KOG99905.1 - 2.9 7.5 14.3 4.6 6.8 3.9 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) SlyX PF04102.7 KOG99905.1 - 2.9 8.3 15.2 2.4 8.5 0.7 4.1 3 0 0 3 3 3 0 SlyX GDA1_CD39 PF01150.12 KOG99906.1 - 6.6e-119 397.2 0.0 8e-119 396.9 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family NAD_kinase PF01513.16 KOG99907.1 - 1.7e-81 273.1 0.0 2.2e-81 272.7 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase Glyco_hydro_16 PF00722.16 KOG99908.1 - 1.3e-40 138.7 5.9 1.3e-40 138.7 4.1 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.14 KOG99908.1 - 0.01 15.8 12.5 0.023 14.6 8.7 1.5 1 0 0 1 1 1 0 Chitin recognition protein YcgR_2 PF12945.2 KOG99908.1 - 0.098 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Flagellar protein YcgR Ashwin PF15323.1 KOG99908.1 - 8.2 6.3 17.6 18 5.2 12.2 1.5 1 0 0 1 1 1 0 Developmental protein Cytochrom_C PF00034.16 KOG99909.1 - 3e-09 37.5 0.5 4.9e-09 36.8 0.3 1.4 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 KOG99909.1 - 1e-07 32.0 1.9 2e-06 27.8 1.3 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.1 KOG99909.1 - 0.0072 15.7 0.6 0.021 14.2 0.1 1.9 2 0 0 2 2 2 1 Cytochrome c-550 domain HAD_2 PF13419.1 KOG99910.1 - 1.2e-17 64.6 0.0 1.7e-17 64.2 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase UBA PF00627.26 KOG99911.1 - 2.9e-25 87.3 0.7 2.1e-14 52.8 0.0 2.5 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.18 KOG99911.1 - 2.9e-17 61.8 0.6 9.4e-17 60.1 0.5 1.8 2 0 0 2 2 2 1 Ubiquitin family XPC-binding PF09280.6 KOG99911.1 - 8.6e-14 50.7 0.1 1.6e-13 49.8 0.1 1.4 1 0 0 1 1 1 1 XPC-binding domain Rad60-SLD PF11976.3 KOG99911.1 - 7.9e-08 31.8 0.1 2e-07 30.6 0.1 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.1 KOG99911.1 - 4.7e-06 26.4 0.0 1e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 KOG99911.1 - 0.0021 18.1 0.0 0.0044 17.1 0.0 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain CUE PF02845.11 KOG99911.1 - 0.0053 16.2 1.2 2.9 7.4 0.0 4.3 3 2 1 4 4 4 1 CUE domain DUF444 PF04285.7 KOG99911.1 - 0.0087 14.7 0.9 0.014 14.0 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF444) RepB PF07506.6 KOG99911.1 - 0.08 12.8 0.2 0.35 10.7 0.0 2.0 1 1 1 2 2 2 0 RepB plasmid partitioning protein DUF3306 PF11748.3 KOG99911.1 - 2.4 8.8 12.3 0.08 13.6 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Anp1 PF03452.9 KOG99912.1 - 1.3e-122 408.1 0.0 3.4e-122 406.8 0.0 1.6 2 0 0 2 2 2 1 Anp1 AAR2 PF05282.6 KOG99912.1 - 0.042 12.7 4.6 0.065 12.1 3.2 1.2 1 0 0 1 1 1 0 AAR2 protein eIF-5a PF01287.15 KOG99913.1 - 5.7e-28 96.6 0.6 8.4e-28 96.1 0.4 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold KOW PF00467.24 KOG99913.1 - 0.00092 18.8 0.4 0.0018 17.9 0.3 1.5 1 0 0 1 1 1 1 KOW motif EFP_N PF08207.7 KOG99913.1 - 0.0043 16.9 0.0 0.0066 16.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain TcdB_toxin_midN PF12256.3 KOG99913.1 - 0.058 12.8 0.0 0.078 12.4 0.0 1.2 1 0 0 1 1 1 0 Insecticide toxin TcdB middle/N-terminal region MCM PF00493.18 KOG99914.1 - 4.4e-129 430.0 0.1 6.3e-129 429.5 0.1 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 KOG99914.1 - 1.2e-24 87.0 0.0 5.1e-24 85.0 0.0 2.1 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 KOG99914.1 - 1.2e-07 31.1 0.0 1.5e-06 27.5 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 KOG99914.1 - 0.0028 17.2 0.3 0.011 15.2 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ORC6 PF05460.8 KOG99914.1 - 0.009 15.1 3.5 0.016 14.2 2.4 1.4 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Sigma54_activat PF00158.21 KOG99914.1 - 0.014 14.8 0.0 0.037 13.5 0.0 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Hydrolase PF00702.21 KOG99915.1 - 2.6e-24 86.8 0.0 7.6e-24 85.3 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOG99915.1 - 2.6e-23 83.1 0.1 6.4e-23 81.9 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 KOG99915.1 - 5.4e-17 61.5 0.2 2.4e-16 59.4 0.1 2.0 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 KOG99915.1 - 1e-06 28.6 0.0 2.1e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 KOG99915.1 - 0.00066 19.3 0.1 0.0066 16.0 0.0 2.4 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 KOG99915.1 - 0.068 12.4 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase HSP70 PF00012.15 KOG99916.1 - 5.4e-260 863.4 11.7 6.2e-260 863.2 8.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOG99916.1 - 1.6e-16 59.8 2.5 2.1e-14 52.8 0.5 2.5 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 KOG99916.1 - 0.00075 19.1 0.0 0.0021 17.7 0.0 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 KOG99916.1 - 0.044 13.6 11.0 2.8 7.8 0.0 4.5 4 1 0 4 4 4 0 Cell division protein FtsA Hydantoinase_A PF01968.13 KOG99916.1 - 0.1 11.6 2.8 0.24 10.4 0.1 2.7 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase RIX1 PF08167.7 KOG99916.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 rRNA processing/ribosome biogenesis Phos_pyr_kin PF08543.7 KOG99917.1 - 3.1e-11 42.9 0.0 3.9e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 KOG99917.1 - 1.3e-10 40.8 0.0 3.7e-09 36.1 0.0 2.1 2 0 0 2 2 2 2 pfkB family carbohydrate kinase ATP-synt_C PF00137.16 KOG99918.1 - 4.6e-32 109.7 27.6 1.9e-18 66.1 7.0 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF2970 PF11174.3 KOG99918.1 - 1.5 8.4 8.5 0.41 10.2 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Ribosomal_L7Ae PF01248.21 KOG99919.1 - 1.2e-27 95.2 0.0 1.4e-27 95.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 KOG99919.1 - 0.012 15.4 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 0 RNase P subunit Pop3 PELOTA_1 PF15608.1 KOG99919.1 - 0.028 14.2 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 PELOTA RNA binding domain UCR_TM PF02921.9 KOG99921.1 - 3.7e-19 68.7 0.9 6.4e-19 67.9 0.7 1.4 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.21 KOG99921.1 - 1.6e-17 62.8 0.0 2.6e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain DUF2235 PF09994.4 KOG99922.1 - 1e-86 290.8 0.0 1.4e-86 290.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Sec7 PF01369.15 KOG99923.1 - 3.4e-64 216.0 0.8 3.4e-64 216.0 0.6 2.4 2 1 1 3 3 3 1 Sec7 domain Fucose_iso_N2 PF07882.7 KOG99923.1 - 0.003 17.2 1.4 0.021 14.5 0.0 2.8 3 0 0 3 3 3 1 L-fucose isomerase, second N-terminal domain Alpha-amylase_C PF02806.13 KOG99924.1 - 1.3e-26 92.5 3.3 5.7e-26 90.4 0.2 2.8 3 0 0 3 3 3 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.19 KOG99924.1 - 2.4e-16 60.0 0.2 2.5e-15 56.7 0.1 2.4 1 1 1 2 2 2 1 Alpha amylase, catalytic domain CBM_48 PF02922.13 KOG99924.1 - 4.3e-15 55.5 0.0 1.1e-14 54.2 0.0 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Tenui_N PF05733.6 KOG99924.1 - 0.02 14.1 0.0 1.8 7.8 0.0 2.1 2 0 0 2 2 2 0 Tenuivirus/Phlebovirus nucleocapsid protein UQ_con PF00179.21 KOG99925.1 - 2e-38 131.0 0.1 2.3e-38 130.7 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 KOG99925.1 - 0.059 13.2 0.1 0.11 12.4 0.1 1.7 1 1 0 1 1 1 0 RWD domain BUD22 PF09073.5 KOG99925.1 - 1.9 7.4 7.0 2.2 7.2 4.8 1.1 1 0 0 1 1 1 0 BUD22 Arm PF00514.18 KOG99926.1 - 4e-72 235.8 24.7 1.5e-12 46.8 0.0 10.5 10 0 0 10 10 10 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOG99926.1 - 4.8e-26 90.8 8.0 1e-06 28.9 0.0 7.3 2 2 5 7 7 7 6 HEAT repeats HEAT_EZ PF13513.1 KOG99926.1 - 3.5e-16 59.1 15.1 0.00016 22.0 0.3 8.4 7 1 2 9 9 8 4 HEAT-like repeat HEAT PF02985.17 KOG99926.1 - 9.3e-16 56.4 27.7 0.012 15.6 0.0 11.1 13 0 0 13 13 12 3 HEAT repeat Adaptin_N PF01602.15 KOG99926.1 - 5.4e-13 48.1 21.3 4.1e-08 31.9 2.0 2.9 1 1 2 3 3 3 3 Adaptin N terminal region KAP PF05804.7 KOG99926.1 - 1.5e-10 39.7 0.6 1e-09 36.9 0.4 2.0 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) Arm_2 PF04826.8 KOG99926.1 - 3.8e-10 39.2 8.3 0.00019 20.6 0.2 4.0 2 1 2 4 4 4 3 Armadillo-like Vac14_Fab1_bd PF12755.2 KOG99926.1 - 2e-05 24.8 0.3 0.15 12.4 0.0 4.1 3 2 1 4 4 4 2 Vacuolar 14 Fab1-binding region V-ATPase_H_N PF03224.9 KOG99926.1 - 5e-05 22.5 3.0 0.0044 16.1 0.8 3.3 1 1 1 2 2 2 1 V-ATPase subunit H DUF2454 PF10521.4 KOG99926.1 - 0.00048 19.2 0.0 0.3 10.0 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF2454) RIX1 PF08167.7 KOG99926.1 - 0.00095 18.8 1.5 0.013 15.2 0.1 3.0 3 1 0 3 3 3 1 rRNA processing/ribosome biogenesis V-ATPase_H_C PF11698.3 KOG99926.1 - 0.0048 16.8 2.2 1.3 8.9 0.1 4.2 2 2 4 6 6 6 1 V-ATPase subunit H DUF1981 PF09324.5 KOG99926.1 - 0.039 13.4 0.4 26 4.4 0.0 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF1981) YjeF_N PF03853.10 KOG99927.1 - 2.2e-34 118.4 0.0 4e-34 117.6 0.0 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.5 KOG99927.1 - 1e-14 54.8 7.3 1e-14 54.8 5.1 2.5 2 0 0 2 2 2 1 FDF domain Phosphodiest PF01663.17 KOG99928.1 - 8.8e-66 222.6 0.5 1e-65 222.4 0.3 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 KOG99928.1 - 0.064 12.4 0.0 0.23 10.5 0.0 1.9 1 1 1 2 2 2 0 Sulfatase FlaC_arch PF05377.6 KOG99929.1 - 0.08 12.8 0.0 0.56 10.1 0.0 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) PMP1_2 PF08114.6 KOG99930.1 - 3.1e-28 96.9 4.1 3.3e-28 96.8 2.9 1.0 1 0 0 1 1 1 1 ATPase proteolipid family DUF1049 PF06305.6 KOG99930.1 - 0.021 14.2 0.4 0.026 13.9 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Chordopox_A13L PF05961.6 KOG99930.1 - 0.074 12.9 0.7 0.084 12.8 0.5 1.1 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Vpu PF00558.14 KOG99930.1 - 0.081 12.4 0.9 0.079 12.5 0.6 1.0 1 0 0 1 1 1 0 Vpu protein DUF1443 PF07280.6 KOG99930.1 - 0.12 11.9 1.4 0.16 11.5 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1443) RCR PF12273.3 KOG99930.1 - 0.27 11.7 1.3 0.31 11.5 0.9 1.0 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red PCI PF01399.22 KOG99931.1 - 0.096 13.0 0.0 0.25 11.6 0.0 1.8 1 1 0 1 1 1 0 PCI domain RNA_GG_bind PF10258.4 KOG99931.1 - 0.18 11.4 1.5 0.35 10.6 0.2 2.2 2 0 0 2 2 2 0 PHAX RNA-binding domain zf-Nse PF11789.3 KOG99932.1 - 5.2e-22 77.1 1.5 9.2e-22 76.3 0.4 2.0 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KOG99932.1 - 0.0008 19.0 0.3 0.0025 17.4 0.2 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.1 KOG99932.1 - 0.0021 17.8 1.9 0.0078 16.0 0.2 2.7 2 1 1 3 3 3 1 Ring finger domain zf-Apc11 PF12861.2 KOG99932.1 - 0.0047 16.7 0.3 0.011 15.4 0.2 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 KOG99932.1 - 0.0047 16.9 0.1 0.015 15.4 0.1 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger zf-MIZ PF02891.15 KOG99932.1 - 0.008 15.6 1.6 0.02 14.4 0.5 2.2 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-C3HC4 PF00097.20 KOG99932.1 - 0.0086 15.7 0.5 0.026 14.1 0.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ku_PK_bind PF08785.6 KOG99932.1 - 0.024 14.5 0.1 0.053 13.4 0.1 1.5 1 0 0 1 1 1 0 Ku C terminal domain like HR1 PF02185.11 KOG99932.1 - 0.089 12.5 0.0 0.22 11.2 0.0 1.7 2 0 0 2 2 2 0 Hr1 repeat Fzo_mitofusin PF04799.8 KOG99932.1 - 0.13 11.6 1.5 0.28 10.5 0.2 1.9 2 0 0 2 2 2 0 fzo-like conserved region zf-C3HC4_2 PF13923.1 KOG99932.1 - 0.83 9.7 3.3 0.92 9.5 1.0 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TPP_enzyme_N PF02776.13 KOG99933.1 - 1.4e-42 145.0 0.0 2e-41 141.3 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 KOG99933.1 - 3.3e-25 88.4 0.0 7.1e-25 87.3 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 KOG99933.1 - 8e-21 74.2 0.1 8e-20 70.9 0.0 2.5 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain zf-Tim10_DDP PF02953.10 KOG99934.1 - 9.9e-21 72.8 7.6 1.3e-20 72.4 5.2 1.3 1 1 0 1 1 1 1 Tim10/DDP family zinc finger Mmp37 PF09139.6 KOG99934.1 - 0.024 13.6 0.6 0.027 13.5 0.4 1.0 1 0 0 1 1 1 0 Mitochondrial matrix Mmp37 DUF1178 PF06676.6 KOG99934.1 - 0.044 13.9 0.3 0.066 13.4 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1178) Pepsin-I3 PF06394.8 KOG99934.1 - 0.094 12.3 3.1 0.54 9.9 0.0 2.2 2 1 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain Gemini_AL1_M PF08283.6 KOG99934.1 - 0.14 12.0 0.2 0.15 11.9 0.1 1.2 1 0 0 1 1 1 0 Geminivirus rep protein central domain CARM1 PF11531.3 KOG99934.1 - 0.17 11.6 1.3 0.38 10.4 0.9 1.7 1 1 0 1 1 1 0 Coactivator-associated arginine methyltransferase 1 N terminal Vicilin_N PF04702.7 KOG99934.1 - 0.51 9.9 6.0 0.7 9.5 4.2 1.2 1 0 0 1 1 1 0 Vicilin N terminal region OMPdecase PF00215.19 KOG99935.1 - 1e-74 250.7 0.0 1.2e-74 250.5 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family bZIP_1 PF00170.16 KOG99937.1 - 2.6e-16 59.3 10.4 5.5e-16 58.2 7.2 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 KOG99937.1 - 6.4e-12 45.0 12.4 1.1e-11 44.3 8.6 1.3 1 0 0 1 1 1 1 Basic region leucine zipper FA_desaturase PF00487.19 KOG99937.1 - 0.01 15.3 0.8 0.013 14.9 0.6 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Zip PF02535.17 KOG99937.1 - 0.03 13.3 0.6 0.033 13.1 0.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1843 PF08898.5 KOG99937.1 - 0.04 13.9 2.0 0.09 12.8 1.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1843) DivIC PF04977.10 KOG99937.1 - 0.6 9.6 3.6 1.2 8.6 2.5 1.5 1 0 0 1 1 1 0 Septum formation initiator bZIP_Maf PF03131.12 KOG99937.1 - 1 9.7 13.5 0.095 13.0 5.7 1.9 2 0 0 2 2 2 0 bZIP Maf transcription factor DUF904 PF06005.7 KOG99937.1 - 5.3 7.3 10.3 0.19 12.0 2.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Gti1_Pac2 PF09729.4 KOG99939.1 - 2.9e-55 186.6 0.0 2.9e-55 186.6 0.0 3.9 4 0 0 4 4 4 2 Gti1/Pac2 family Mito_carr PF00153.22 KOG99940.1 - 2.9e-72 238.4 2.1 6.9e-24 83.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3552 PF12072.3 KOG99941.1 - 0.023 13.8 1.2 0.036 13.2 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) UAA PF08449.6 KOG99942.1 - 9e-92 307.2 16.6 1e-91 307.0 11.5 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOG99942.1 - 2.2e-09 37.1 8.0 2.2e-09 37.1 5.5 2.4 2 0 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOG99942.1 - 1.8 8.5 24.4 0.12 12.4 4.4 3.4 3 1 1 4 4 4 0 EamA-like transporter family DUF914 PF06027.7 KOG99942.1 - 6.2 5.5 16.6 0.82 8.4 3.3 2.5 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF914) Prefoldin_2 PF01920.15 KOG99943.1 - 9.7e-21 73.5 6.4 1.1e-20 73.3 4.4 1.0 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.12 KOG99943.1 - 0.0058 16.2 3.1 0.91 9.1 0.2 2.2 1 1 1 2 2 2 2 Prefoldin subunit DUF2383 PF09537.5 KOG99943.1 - 0.037 14.2 0.4 0.077 13.2 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) DUF2935 PF11155.3 KOG99943.1 - 0.079 13.0 0.6 0.1 12.7 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) BLOC1_2 PF10046.4 KOG99943.1 - 0.12 12.5 0.7 0.12 12.5 0.5 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_32 PF13654.1 KOG99943.1 - 0.18 10.4 3.4 0.22 10.1 2.4 1.0 1 0 0 1 1 1 0 AAA domain APG6 PF04111.7 KOG99943.1 - 0.21 10.6 3.7 0.25 10.3 2.3 1.3 1 1 0 1 1 1 0 Autophagy protein Apg6 DUF342 PF03961.8 KOG99943.1 - 0.36 9.2 6.3 0.74 8.1 4.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF342) CASP_C PF08172.7 KOG99943.1 - 0.43 9.5 3.6 0.26 10.2 0.4 1.8 2 0 0 2 2 2 0 CASP C terminal Occludin_ELL PF07303.8 KOG99943.1 - 0.77 10.5 6.0 4.1 8.1 0.7 2.1 1 1 1 2 2 2 0 Occludin homology domain GrpE PF01025.14 KOG99943.1 - 1.1 8.8 4.8 2.4 7.6 0.3 2.0 2 0 0 2 2 2 0 GrpE Cortex-I_coil PF09304.5 KOG99943.1 - 1.2 9.1 5.2 1.6 8.8 0.4 2.2 1 1 1 2 2 2 0 Cortexillin I, coiled coil Spc24 PF08286.6 KOG99943.1 - 2.6 7.7 7.1 3 7.5 0.5 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DDOST_48kD PF03345.9 KOG99944.1 - 3.8e-135 450.6 5.8 4.4e-135 450.4 4.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta PsbU PF06514.6 KOG99944.1 - 0.055 13.3 0.2 1.1 9.1 0.0 2.7 3 0 0 3 3 3 0 Photosystem II 12 kDa extrinsic protein (PsbU) Tail_tube PF10618.4 KOG99945.1 - 0.069 12.8 0.3 0.12 12.1 0.2 1.4 1 0 0 1 1 1 0 Phage tail tube protein DUF4366 PF14283.1 KOG99945.1 - 0.092 12.1 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Nop16 PF09420.5 KOG99946.1 - 4.2e-63 212.3 9.4 4.9e-63 212.1 6.5 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 PCNP PF15473.1 KOG99946.1 - 0.092 13.0 1.4 0.17 12.2 1.0 1.4 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family Flagellin_C PF00700.16 KOG99946.1 - 0.18 11.9 0.6 18 5.5 0.1 2.4 2 0 0 2 2 2 0 Bacterial flagellin C-terminal helical region PMI_typeI PF01238.16 KOG99947.1 - 6.6e-141 469.6 0.0 7.5e-141 469.4 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.14 KOG99947.1 - 1.2e-08 34.7 0.0 2.2e-05 24.1 0.0 2.9 3 0 0 3 3 3 2 AraC-like ligand binding domain Cupin_2 PF07883.6 KOG99947.1 - 0.0012 18.3 0.0 1.7 8.1 0.0 2.4 2 0 0 2 2 2 2 Cupin domain Het-C PF07217.6 KOG99947.1 - 0.052 11.7 0.0 0.073 11.2 0.0 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C AraC_binding_2 PF14525.1 KOG99947.1 - 0.2 11.2 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 AraC-binding-like domain NAD_binding_10 PF13460.1 KOG99948.1 - 4.3e-11 43.1 0.0 5.3e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding HIM1 PF08732.5 KOG99948.1 - 2.6e-08 32.7 0.0 2.9e-07 29.3 0.0 2.2 1 1 0 1 1 1 1 HIM1 Epimerase PF01370.16 KOG99948.1 - 9.4e-05 21.9 0.0 0.00076 18.9 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 KOG99948.1 - 0.01 15.0 0.0 0.026 13.7 0.0 1.6 1 1 0 1 1 1 0 NmrA-like family Semialdhyde_dh PF01118.19 KOG99948.1 - 0.018 15.3 0.0 0.41 10.9 0.0 2.1 1 1 1 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.7 KOG99948.1 - 0.14 11.0 0.0 0.76 8.6 0.0 1.9 1 1 1 3 3 3 0 Male sterility protein GDA1_CD39 PF01150.12 KOG99949.1 - 1.6e-161 537.6 0.0 3.7e-161 536.4 0.0 1.5 2 0 0 2 2 2 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.11 KOG99949.1 - 0.031 13.4 0.0 0.068 12.3 0.0 1.5 1 0 0 1 1 1 0 Ppx/GppA phosphatase family CAP_GLY PF01302.20 KOG99950.1 - 2.3e-16 59.2 0.3 3.7e-16 58.5 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.2 KOG99950.1 - 1.7e-15 56.2 32.2 1.5e-06 27.7 0.8 5.8 5 0 0 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOG99950.1 - 3.5e-09 36.2 14.8 3.5e-07 29.8 2.8 5.7 1 1 6 7 7 7 6 Leucine rich repeat LRR_1 PF00560.28 KOG99950.1 - 1.4e-08 33.6 25.2 0.069 13.2 0.0 8.8 6 2 1 7 7 7 4 Leucine Rich Repeat LRR_6 PF13516.1 KOG99950.1 - 1.8e-07 30.4 31.5 0.94 9.7 0.1 9.4 10 0 0 10 10 10 4 Leucine Rich repeat LRR_7 PF13504.1 KOG99950.1 - 7.7e-07 28.3 19.0 15 6.3 0.0 9.1 9 0 0 9 9 9 3 Leucine rich repeat PUA PF01472.15 KOG99951.1 - 3.4e-14 52.3 0.0 3.9e-14 52.1 0.0 1.0 1 0 0 1 1 1 1 PUA domain DpnD-PcfM PF14207.1 KOG99951.1 - 0.11 12.2 0.1 0.16 11.7 0.1 1.2 1 0 0 1 1 1 0 DpnD/PcfM-like protein Sec3_C PF09763.4 KOG99953.1 - 2.2e-167 558.3 31.5 2.2e-167 558.3 21.9 2.2 2 0 0 2 2 2 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.1 KOG99953.1 - 2e-25 88.4 0.3 2e-25 88.4 0.2 2.6 2 0 0 2 2 2 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH NTF2 PF02136.15 KOG99954.1 - 1.1e-35 122.5 0.5 1.2e-35 122.4 0.4 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4518 PF15008.1 KOG99954.1 - 0.00096 18.2 0.1 0.0017 17.4 0.1 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4518) DUF4440 PF14534.1 KOG99954.1 - 0.075 13.2 0.0 0.093 12.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Methyltransf_6 PF03737.10 KOG99955.1 - 4.2e-42 143.6 0.0 5.5e-42 143.2 0.0 1.1 1 0 0 1 1 1 1 Demethylmenaquinone methyltransferase SRP1_TIP1 PF00660.12 KOG99956.1 - 1.1e-41 140.9 0.6 3.3e-41 139.3 0.4 1.8 1 0 0 1 1 1 1 Seripauperin and TIP1 family PIR PF00399.14 KOG99956.1 - 8.8e-09 34.4 7.6 9.2e-08 31.1 5.3 3.0 1 0 0 1 1 1 1 Yeast PIR protein repeat Spc42p PF11544.3 KOG99956.1 - 0.026 14.4 0.0 0.065 13.1 0.0 1.6 1 0 0 1 1 1 0 Spindle pole body component Spc42p SLD3 PF08639.5 KOG99956.1 - 0.15 10.6 14.3 0.21 10.1 9.9 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 FAM196 PF15265.1 KOG99956.1 - 0.19 10.9 13.3 0.23 10.6 9.2 1.1 1 0 0 1 1 1 0 FAM196 family Macoilin PF09726.4 KOG99956.1 - 0.47 8.6 27.7 0.67 8.1 19.2 1.2 1 0 0 1 1 1 0 Transmembrane protein TFIIA PF03153.8 KOG99956.1 - 0.52 10.1 13.6 0.61 9.9 9.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hid1 PF12722.2 KOG99956.1 - 1.1 6.8 7.1 1 6.9 4.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DDHD PF02862.12 KOG99956.1 - 4.7 6.9 17.0 7.6 6.2 11.8 1.3 1 0 0 1 1 1 0 DDHD domain Proteasome PF00227.21 KOG99957.1 - 2e-44 151.1 0.0 2.3e-44 150.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit OB_NTP_bind PF07717.11 KOG99958.1 - 7.2e-27 93.4 0.0 2e-26 92.0 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 KOG99958.1 - 4.5e-26 90.8 2.2 5.5e-26 90.5 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) S1 PF00575.18 KOG99958.1 - 1.5e-13 50.5 0.2 4.8e-13 48.9 0.1 1.9 1 0 0 1 1 1 1 S1 RNA binding domain Helicase_C PF00271.26 KOG99958.1 - 9.9e-13 47.7 0.0 3.7e-12 45.9 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 KOG99958.1 - 1.8e-05 24.8 0.0 5.2e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 KOG99958.1 - 5.2e-05 22.8 0.4 0.00019 20.9 0.3 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 KOG99958.1 - 0.00022 20.2 0.0 0.0013 17.6 0.0 2.2 3 0 0 3 3 3 1 Type II/IV secretion system protein PWI PF01480.12 KOG99958.1 - 0.0018 18.3 1.1 0.33 11.0 0.1 2.8 2 0 0 2 2 2 1 PWI domain AAA_14 PF13173.1 KOG99958.1 - 0.0033 17.3 0.0 0.036 13.9 0.0 2.6 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.22 KOG99958.1 - 0.0052 17.0 5.4 0.32 11.2 0.0 4.3 3 1 1 4 4 4 1 ABC transporter AAA_30 PF13604.1 KOG99958.1 - 0.021 14.3 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 KOG99958.1 - 0.024 14.6 0.0 0.14 12.1 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain SRP54 PF00448.17 KOG99958.1 - 0.05 13.0 0.1 0.11 11.9 0.1 1.6 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA PF00004.24 KOG99958.1 - 0.074 13.2 1.7 0.46 10.6 0.1 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NAD_binding_8 PF13450.1 KOG99959.1 - 6.6e-12 45.2 0.0 1.4e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOG99959.1 - 1.4e-05 24.1 0.0 4.7e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOG99959.1 - 5.3e-05 23.5 0.4 0.0078 16.5 0.0 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 KOG99959.1 - 6.5e-05 22.1 0.0 0.00033 19.8 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Thi4 PF01946.12 KOG99959.1 - 0.0012 17.9 0.0 0.0026 16.8 0.0 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.1 KOG99959.1 - 0.0092 15.7 0.0 0.024 14.3 0.0 1.7 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 KOG99959.1 - 0.072 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Globin PF00042.17 KOG99959.1 - 0.075 13.3 0.1 0.18 12.1 0.1 1.6 1 0 0 1 1 1 0 Globin AMP-binding PF00501.23 KOG99960.1 - 5.7e-66 222.6 0.0 7.4e-66 222.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme SRP1_TIP1 PF00660.12 KOG99961.1 - 2.4e-32 110.8 0.1 3.1e-32 110.5 0.1 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family EB1 PF03271.12 KOG99962.1 - 3.9e-20 71.6 0.1 8.1e-20 70.6 0.1 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.26 KOG99962.1 - 9.5e-07 28.8 0.4 1.7e-06 27.9 0.3 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain Tmemb_cc2 PF10267.4 KOG99962.1 - 0.009 14.6 0.0 0.012 14.2 0.0 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein FliJ PF02050.11 KOG99962.1 - 0.022 14.8 0.3 0.039 14.0 0.2 1.4 1 0 0 1 1 1 0 Flagellar FliJ protein CENP-F_leu_zip PF10473.4 KOG99962.1 - 0.042 13.6 0.3 0.069 13.0 0.2 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Laminin_II PF06009.7 KOG99962.1 - 0.061 13.0 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Laminin Domain II DivIC PF04977.10 KOG99962.1 - 0.1 12.1 0.1 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Septum formation initiator DUF2968 PF11180.3 KOG99962.1 - 0.1 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Peptidase_M41 PF01434.13 KOG99963.1 - 1.9e-75 252.9 0.0 2.8e-75 252.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 KOG99963.1 - 8.4e-43 145.7 0.0 1.7e-42 144.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.10 KOG99963.1 - 1.1e-06 28.7 0.6 3.2e-06 27.2 0.4 1.8 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.9 KOG99963.1 - 3.1e-05 23.7 0.1 0.00019 21.1 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 KOG99963.1 - 0.00086 19.4 0.2 0.067 13.3 0.1 3.0 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KOG99963.1 - 0.0015 19.3 0.7 0.0046 17.7 0.0 2.4 2 1 0 2 2 1 1 AAA domain AAA_19 PF13245.1 KOG99963.1 - 0.0048 16.6 0.7 0.014 15.1 0.5 1.7 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 KOG99963.1 - 0.0051 15.9 0.0 0.0098 14.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 KOG99963.1 - 0.0053 15.5 0.0 0.0097 14.6 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 KOG99963.1 - 0.011 15.2 0.0 0.021 14.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_2 PF07724.9 KOG99963.1 - 0.011 15.6 0.0 0.058 13.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 KOG99963.1 - 0.018 14.9 0.0 0.086 12.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 KOG99963.1 - 0.025 14.5 0.1 0.081 12.8 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.7 KOG99963.1 - 0.046 12.8 0.0 0.088 11.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.1 KOG99963.1 - 0.085 12.2 0.0 0.19 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Tim54 PF11711.3 KOG99963.1 - 0.12 10.9 0.8 0.22 10.1 0.2 1.5 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 AAA_18 PF13238.1 KOG99963.1 - 0.16 12.2 1.1 0.7 10.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain APG6 PF04111.7 KOG99964.1 - 1.7e-05 24.0 9.5 2.1e-05 23.7 6.6 1.0 1 0 0 1 1 1 1 Autophagy protein Apg6 Filament PF00038.16 KOG99964.1 - 1.8e-05 24.3 12.0 2.1e-05 24.1 8.3 1.0 1 0 0 1 1 1 1 Intermediate filament protein Phasin_2 PF09361.5 KOG99964.1 - 0.0054 16.7 1.2 0.0054 16.7 0.8 2.4 1 1 1 2 2 2 1 Phasin protein CALCOCO1 PF07888.6 KOG99964.1 - 0.0055 15.0 7.6 0.0058 14.9 5.3 1.0 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like TMF_TATA_bd PF12325.3 KOG99964.1 - 0.0075 16.0 9.1 0.025 14.3 6.5 1.9 1 1 0 1 1 1 1 TATA element modulatory factor 1 TATA binding HAUS6_N PF14661.1 KOG99964.1 - 0.0086 15.4 8.7 0.0094 15.3 6.0 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus Citrate_synt PF00285.16 KOG99964.1 - 0.01 14.6 1.0 0.012 14.3 0.7 1.0 1 0 0 1 1 1 0 Citrate synthase Mod_r PF07200.8 KOG99964.1 - 0.011 15.6 7.0 0.014 15.3 4.6 1.4 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein GAS PF13851.1 KOG99964.1 - 0.013 14.7 5.5 0.018 14.2 3.8 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding RmuC PF02646.11 KOG99964.1 - 0.03 13.1 4.4 0.035 12.9 3.1 1.2 1 0 0 1 1 1 0 RmuC family DUF4407 PF14362.1 KOG99964.1 - 0.031 13.2 8.1 0.037 12.9 5.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Herpes_UL6 PF01763.11 KOG99964.1 - 0.032 12.4 4.6 0.034 12.3 3.2 1.0 1 0 0 1 1 1 0 Herpesvirus UL6 like AAA_13 PF13166.1 KOG99964.1 - 0.037 12.5 1.8 0.038 12.4 1.2 1.0 1 0 0 1 1 1 0 AAA domain zf-C4H2 PF10146.4 KOG99964.1 - 0.038 14.0 1.3 0.041 13.9 0.9 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein Baculo_PEP_C PF04513.7 KOG99964.1 - 0.039 13.7 2.5 0.063 13.0 1.7 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Methyltrans_Mon PF14314.1 KOG99964.1 - 0.039 11.7 1.0 0.039 11.7 0.7 1.0 1 0 0 1 1 1 0 Virus-capping methyltransferase DUF972 PF06156.8 KOG99964.1 - 0.049 13.9 6.1 0.11 12.8 4.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF972) NTPase_1 PF03266.10 KOG99964.1 - 0.051 13.2 0.1 0.21 11.3 0.1 1.9 1 1 1 2 2 2 0 NTPase TBPIP PF07106.8 KOG99964.1 - 0.052 13.1 5.4 0.063 12.8 3.8 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) IncA PF04156.9 KOG99964.1 - 0.069 12.7 14.2 0.11 12.1 9.8 1.3 1 0 0 1 1 1 0 IncA protein Peptidase_M13_N PF05649.8 KOG99964.1 - 0.07 12.1 2.0 0.074 12.0 1.4 1.1 1 0 0 1 1 1 0 Peptidase family M13 DUF342 PF03961.8 KOG99964.1 - 0.075 11.4 1.1 0.079 11.3 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DivIVA PF05103.8 KOG99964.1 - 0.11 12.5 6.7 0.17 11.9 4.6 1.5 1 1 0 1 1 1 0 DivIVA protein Spc7 PF08317.6 KOG99964.1 - 0.11 11.1 7.1 0.099 11.2 4.4 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein V-ATPase_C PF03223.10 KOG99964.1 - 0.11 11.3 1.3 0.13 11.0 0.9 1.0 1 0 0 1 1 1 0 V-ATPase subunit C Fmp27_WPPW PF10359.4 KOG99964.1 - 0.12 10.7 6.5 0.14 10.5 4.5 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain IFT57 PF10498.4 KOG99964.1 - 0.12 11.0 5.8 0.13 10.9 4.0 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Syntaxin-6_N PF09177.6 KOG99964.1 - 0.14 12.6 5.6 0.17 12.2 3.9 1.2 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Jnk-SapK_ap_N PF09744.4 KOG99964.1 - 0.15 12.0 7.6 0.23 11.4 4.4 1.8 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF948 PF06103.6 KOG99964.1 - 0.22 11.4 0.8 0.58 10.0 0.6 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF3251 PF11622.3 KOG99964.1 - 0.24 10.8 4.0 0.18 11.2 1.7 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF3251) Sec34 PF04136.10 KOG99964.1 - 0.25 11.0 3.5 0.36 10.5 1.9 1.6 1 1 0 1 1 1 0 Sec34-like family Phage_GPO PF05929.6 KOG99964.1 - 0.29 10.3 6.0 0.31 10.2 4.2 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase V_ATPase_I PF01496.14 KOG99964.1 - 0.34 8.7 4.1 0.36 8.6 2.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ATG16 PF08614.6 KOG99964.1 - 0.37 10.5 15.5 0.41 10.4 7.5 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Mnd1 PF03962.10 KOG99964.1 - 0.38 10.3 8.2 0.48 10.0 5.7 1.3 1 0 0 1 1 1 0 Mnd1 family Prefoldin_2 PF01920.15 KOG99964.1 - 0.43 10.3 10.7 1.6 8.5 1.2 2.6 1 1 1 2 2 2 0 Prefoldin subunit Spc24 PF08286.6 KOG99964.1 - 0.57 9.8 5.5 1.4 8.6 3.8 1.8 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 CENP-F_leu_zip PF10473.4 KOG99964.1 - 0.58 10.0 9.7 0.85 9.4 6.3 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4200 PF13863.1 KOG99964.1 - 0.59 10.0 12.5 11 6.0 6.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Ax_dynein_light PF10211.4 KOG99964.1 - 0.64 9.8 10.8 0.12 12.1 1.5 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain Exonuc_VII_L PF02601.10 KOG99964.1 - 0.75 8.9 7.8 0.84 8.7 5.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit BEX PF04538.7 KOG99964.1 - 0.83 9.8 5.3 0.76 10.0 1.5 2.0 1 1 2 3 3 3 0 Brain expressed X-linked like family HemX PF04375.9 KOG99964.1 - 0.98 7.9 15.6 1.2 7.7 10.8 1.1 1 0 0 1 1 1 0 HemX CENP-H PF05837.7 KOG99964.1 - 1 9.6 8.6 0.47 10.6 4.0 1.7 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Seryl_tRNA_N PF02403.17 KOG99964.1 - 1 9.4 6.7 3.2 7.8 4.4 1.8 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Hemerythrin PF01814.18 KOG99964.1 - 1.1 9.4 8.4 1.8 8.7 2.2 2.2 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain TMF_DNA_bd PF12329.3 KOG99964.1 - 1.2 8.9 5.7 0.94 9.3 1.8 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding NPV_P10 PF05531.7 KOG99964.1 - 1.3 9.2 7.2 2.8 8.2 2.1 2.5 2 1 0 2 2 1 0 Nucleopolyhedrovirus P10 protein Prefoldin PF02996.12 KOG99964.1 - 1.4 8.5 6.6 0.49 10.0 0.6 2.3 1 1 1 2 2 2 0 Prefoldin subunit DUF4140 PF13600.1 KOG99964.1 - 1.5 9.2 13.0 0.26 11.7 5.3 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) SlyX PF04102.7 KOG99964.1 - 1.7 9.0 19.9 0.34 11.2 4.9 3.0 1 1 1 3 3 3 0 SlyX Nup88 PF10168.4 KOG99964.1 - 1.7 6.3 5.7 1.9 6.2 4.0 1.1 1 0 0 1 1 1 0 Nuclear pore component COG2 PF06148.6 KOG99964.1 - 2.1 8.1 5.4 5.1 6.9 3.7 1.8 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 FUSC PF04632.7 KOG99964.1 - 2.2 6.6 15.4 2.6 6.3 10.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family WXG100 PF06013.7 KOG99964.1 - 2.2 8.3 12.8 4.4 7.3 1.5 2.5 1 1 1 2 2 2 0 Proteins of 100 residues with WXG DUF2937 PF11157.3 KOG99964.1 - 2.3 7.5 12.9 1.5 8.1 7.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2937) DUF3287 PF11690.3 KOG99964.1 - 2.9 7.9 9.7 1.4 8.9 3.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3287) DivIC PF04977.10 KOG99964.1 - 3.2 7.2 10.6 0.61 9.6 3.1 2.5 1 1 2 3 3 3 0 Septum formation initiator Atg14 PF10186.4 KOG99964.1 - 4.1 6.2 11.5 5.1 5.9 8.0 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Cep57_MT_bd PF06657.8 KOG99964.1 - 5 7.1 12.3 4.4 7.3 4.6 3.1 2 1 2 4 4 4 0 Centrosome microtubule-binding domain of Cep57 Occludin_ELL PF07303.8 KOG99964.1 - 6.3 7.5 7.5 13 6.5 0.8 2.3 1 1 1 2 2 2 0 Occludin homology domain DUF904 PF06005.7 KOG99964.1 - 7.9 6.8 9.8 41 4.5 6.8 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF904) ADIP PF11559.3 KOG99964.1 - 8.3 6.2 15.6 32 4.4 10.9 1.8 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding YlqD PF11068.3 KOG99964.1 - 8.5 6.4 14.0 9.8 6.2 9.1 1.6 1 1 0 1 1 1 0 YlqD protein Exo_endo_phos PF03372.18 KOG99965.1 - 3.9e-19 69.5 0.0 5.2e-19 69.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Sec61_beta PF03911.11 KOG99966.1 - 6.5e-15 54.6 0.4 8e-15 54.3 0.3 1.1 1 0 0 1 1 1 1 Sec61beta family G-alpha PF00503.15 KOG99967.1 - 2.5e-116 388.5 0.5 3.3e-116 388.1 0.4 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 KOG99967.1 - 4.3e-16 58.6 1.1 2.1e-10 40.0 0.2 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 KOG99967.1 - 0.0012 19.2 0.1 1.6 9.2 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein Gtr1_RagA PF04670.7 KOG99967.1 - 0.0025 17.0 0.6 0.3 10.2 0.1 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region FtsK_SpoIIIE PF01580.13 KOG99967.1 - 0.012 15.0 0.0 0.025 14.0 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.1 KOG99967.1 - 0.047 13.2 0.1 0.14 11.6 0.1 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain Ras PF00071.17 KOG99967.1 - 0.13 11.6 0.6 18 4.6 0.1 2.6 2 1 0 2 2 2 0 Ras family PCI PF01399.22 KOG99968.1 - 1.1e-20 73.8 2.7 2.9e-20 72.5 0.4 2.6 2 0 0 2 2 2 1 PCI domain Rpn3_C PF08375.6 KOG99968.1 - 1.3e-19 70.2 5.7 1.3e-19 70.2 4.0 1.9 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI_Csn8 PF10075.4 KOG99968.1 - 0.0021 17.8 0.1 0.0056 16.4 0.1 1.7 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 MarR_2 PF12802.2 KOG99968.1 - 0.058 13.0 0.0 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 MarR family Med17 PF10156.4 KOG99969.1 - 1.8e-147 491.3 26.1 1.8e-147 491.3 18.1 1.8 1 1 1 2 2 2 1 Subunit 17 of Mediator complex P5CR_dimer PF14748.1 KOG99970.1 - 8.9e-33 112.5 0.5 2e-32 111.3 0.1 1.8 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 KOG99970.1 - 2.1e-11 44.1 0.3 5.3e-11 42.8 0.2 1.7 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.18 KOG99970.1 - 0.026 14.2 0.3 0.056 13.1 0.2 1.6 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DapB_N PF01113.15 KOG99970.1 - 0.067 13.1 0.1 0.54 10.1 0.0 2.2 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Carn_acyltransf PF00755.15 KOG99971.1 - 3.9e-79 266.3 0.4 4.9e-64 216.4 0.0 2.2 2 0 0 2 2 2 2 Choline/Carnitine o-acyltransferase Mg296 PF09644.5 KOG99971.1 - 0.025 14.4 0.2 0.087 12.6 0.1 1.9 1 0 0 1 1 1 0 Mg296 protein GTP_EFTU PF00009.22 KOG99972.1 - 1.7e-38 131.9 0.0 3.1e-38 131.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 KOG99972.1 - 2.4e-36 123.6 0.2 5.3e-36 122.5 0.1 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 KOG99972.1 - 1.3e-11 44.4 0.6 5.7e-11 42.3 0.4 2.2 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KOG99972.1 - 0.0065 16.4 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Notch PF00066.12 KOG99972.1 - 3.5 7.9 5.7 6.7 7.0 4.0 1.5 1 0 0 1 1 1 0 LNR domain CDP-OH_P_transf PF01066.16 KOG99973.1 - 9.3e-12 45.1 3.3 1.9e-11 44.1 2.3 1.5 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase AMPKBI PF04739.10 KOG99974.1 - 5.1e-33 112.9 5.3 5.1e-33 112.9 3.7 2.1 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interation domain FSIP1 PF15554.1 KOG99974.1 - 4.6 5.9 16.3 0.21 10.3 7.2 1.6 2 0 0 2 2 2 0 FSIP1 family zf-H2C2_2 PF13465.1 KOG99975.1 - 2.7e-07 30.5 17.6 5.1e-06 26.5 3.8 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOG99975.1 - 3.8e-06 26.8 11.8 0.00034 20.7 0.6 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 KOG99975.1 - 5.5e-06 26.4 17.4 0.0004 20.5 2.1 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 KOG99975.1 - 0.0041 17.2 5.8 1 9.6 1.7 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding LSM PF01423.17 KOG99976.1 - 9.8e-19 66.6 0.2 1.9e-18 65.7 0.1 1.5 1 0 0 1 1 1 1 LSM domain CHZ PF09649.5 KOG99977.1 - 1.6e-20 71.9 2.5 1.6e-20 71.9 1.7 2.5 3 0 0 3 3 3 1 Histone chaperone domain CHZ BUD22 PF09073.5 KOG99977.1 - 0.5 9.3 27.1 0.68 8.9 18.8 1.2 1 0 0 1 1 1 0 BUD22 TT_ORF2 PF02957.10 KOG99977.1 - 0.82 10.3 16.0 0.23 12.1 5.3 2.2 2 0 0 2 2 2 0 TT viral ORF2 ATP-synt_E PF05680.7 KOG99977.1 - 6.5 6.7 10.7 1.3 9.0 3.1 2.3 2 0 0 2 2 2 0 ATP synthase E chain Ras PF00071.17 KOG99978.1 - 1.2e-61 206.8 0.2 1.4e-61 206.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOG99978.1 - 1.2e-19 70.9 0.0 2.4e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOG99978.1 - 9.3e-14 51.0 0.0 1.2e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOG99978.1 - 8.6e-07 28.9 0.0 1.9e-06 27.8 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOG99978.1 - 8.1e-05 22.1 0.0 0.0004 19.8 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain KAP_NTPase PF07693.9 KOG99978.1 - 0.0002 20.4 0.0 0.00026 20.1 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain AAA_15 PF13175.1 KOG99978.1 - 0.00035 19.7 0.2 0.00057 19.0 0.1 1.3 1 1 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.7 KOG99978.1 - 0.00038 19.6 0.1 0.00055 19.1 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.11 KOG99978.1 - 0.0021 17.2 0.7 0.0046 16.1 0.1 1.9 2 1 0 2 2 2 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOG99978.1 - 0.0044 17.1 0.2 0.023 14.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain TraG_N PF07916.6 KOG99978.1 - 0.012 14.1 0.1 0.016 13.6 0.1 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region PduV-EutP PF10662.4 KOG99978.1 - 0.021 14.3 0.0 0.036 13.5 0.0 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.5 KOG99978.1 - 0.024 13.8 0.2 0.13 11.5 0.0 1.9 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.22 KOG99978.1 - 0.024 14.9 1.3 0.083 13.1 0.9 1.9 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 KOG99978.1 - 0.042 13.8 0.4 0.095 12.6 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.1 KOG99978.1 - 0.047 13.5 0.1 0.12 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain Septin PF00735.13 KOG99978.1 - 0.047 12.6 0.0 0.094 11.7 0.0 1.4 1 0 0 1 1 1 0 Septin FeoB_N PF02421.13 KOG99978.1 - 0.052 12.8 0.0 0.097 11.9 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_18 PF13238.1 KOG99978.1 - 0.077 13.3 0.2 0.73 10.1 0.1 2.4 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 KOG99978.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 NTPase DUF4038 PF13204.1 KOG99979.1 - 0.07 12.4 0.1 0.14 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4038) Ax_dynein_light PF10211.4 KOG99981.1 - 2.2 8.0 14.3 2 8.2 0.3 2.1 2 0 0 2 2 2 0 Axonemal dynein light chain PNRC PF15365.1 KOG99982.1 - 0.17 11.9 0.0 0.17 11.9 0.0 2.2 3 0 0 3 3 3 0 Proline-rich nuclear receptor coactivator ABC_tran PF00005.22 KOG99983.1 - 1.3e-49 168.0 0.0 3.3e-25 88.9 0.0 2.8 3 0 0 3 3 2 2 ABC transporter AAA_21 PF13304.1 KOG99983.1 - 1e-22 81.4 1.6 1.4e-06 28.5 0.0 4.3 2 2 0 3 3 3 3 AAA domain ABC_tran_2 PF12848.2 KOG99983.1 - 2.4e-20 72.1 2.9 2.4e-20 72.1 2.0 2.9 3 0 0 3 3 2 1 ABC transporter SMC_N PF02463.14 KOG99983.1 - 6.9e-10 38.5 1.0 0.51 9.5 0.0 4.5 3 1 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 KOG99983.1 - 1.1e-08 34.5 0.0 0.00096 18.6 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 KOG99983.1 - 5.3e-08 33.0 0.0 0.012 15.7 0.0 3.0 3 0 0 3 3 2 2 AAA domain Miro PF08477.8 KOG99983.1 - 9.3e-08 32.5 0.0 0.0043 17.5 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein DUF258 PF03193.11 KOG99983.1 - 2.1e-07 30.2 0.0 0.00014 21.0 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_18 PF13238.1 KOG99983.1 - 3.6e-07 30.5 0.0 0.006 16.8 0.0 3.4 3 1 0 3 3 3 2 AAA domain AAA_17 PF13207.1 KOG99983.1 - 3.9e-07 30.9 0.1 0.037 14.8 0.0 3.1 2 1 1 3 3 2 2 AAA domain AAA_23 PF13476.1 KOG99983.1 - 6.7e-06 26.5 14.9 0.0018 18.6 0.0 3.7 4 1 0 4 4 3 2 AAA domain NACHT PF05729.7 KOG99983.1 - 1.2e-05 25.0 0.7 0.16 11.6 0.0 2.9 3 0 0 3 3 2 2 NACHT domain MMR_HSR1 PF01926.18 KOG99983.1 - 1.3e-05 25.1 0.1 0.046 13.6 0.1 3.2 3 2 1 4 4 2 2 50S ribosome-binding GTPase RNA_helicase PF00910.17 KOG99983.1 - 2.4e-05 24.4 0.0 0.25 11.5 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA PF00004.24 KOG99983.1 - 2.9e-05 24.2 0.1 0.16 12.1 0.0 3.2 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 KOG99983.1 - 4.5e-05 23.4 0.0 0.25 11.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.1 KOG99983.1 - 6e-05 22.2 0.0 0.67 8.9 0.0 3.6 4 1 0 4 4 3 2 AAA ATPase domain AAA_33 PF13671.1 KOG99983.1 - 6.9e-05 22.7 0.1 0.21 11.4 0.0 3.0 3 0 0 3 3 3 2 AAA domain MobB PF03205.9 KOG99983.1 - 0.00024 20.8 0.2 0.0069 16.0 0.1 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B VirE PF05272.6 KOG99983.1 - 0.00026 20.5 0.2 0.34 10.3 0.0 3.0 3 0 0 3 3 3 1 Virulence-associated protein E AAA_14 PF13173.1 KOG99983.1 - 0.00033 20.5 0.0 1.5 8.6 0.0 3.1 2 0 0 2 2 2 2 AAA domain MCM PF00493.18 KOG99983.1 - 0.00034 19.5 1.8 0.52 9.0 0.0 3.1 3 0 0 3 3 3 1 MCM2/3/5 family AAA_10 PF12846.2 KOG99983.1 - 0.00037 20.0 0.0 0.78 9.1 0.1 3.2 3 0 0 3 3 3 1 AAA-like domain AAA_16 PF13191.1 KOG99983.1 - 0.00059 19.8 2.2 0.63 10.0 0.1 3.4 3 2 0 3 3 3 2 AAA ATPase domain Arch_ATPase PF01637.13 KOG99983.1 - 0.00072 19.3 0.2 2.4 7.7 0.0 3.4 3 1 1 4 4 4 1 Archaeal ATPase AAA_25 PF13481.1 KOG99983.1 - 0.00096 18.5 0.0 1.6 8.1 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.9 KOG99983.1 - 0.0023 17.6 0.0 2.6 7.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DAP3 PF10236.4 KOG99983.1 - 0.0072 15.2 0.8 5.1 5.9 0.0 3.2 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 ArgK PF03308.11 KOG99983.1 - 0.0084 14.9 0.2 1.4 7.6 0.0 2.7 3 0 0 3 3 3 1 ArgK protein DUF815 PF05673.8 KOG99983.1 - 0.01 14.7 0.4 4.8 6.0 0.0 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF815) Rad17 PF03215.10 KOG99983.1 - 0.01 14.5 0.1 1.1 7.9 0.0 2.5 3 0 0 3 3 3 0 Rad17 cell cycle checkpoint protein PduV-EutP PF10662.4 KOG99983.1 - 0.014 14.8 0.3 6.8 6.1 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation T2SE PF00437.15 KOG99983.1 - 0.015 14.1 0.0 0.4 9.5 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein SbcCD_C PF13558.1 KOG99983.1 - 0.016 15.1 0.1 1.3 8.9 0.0 3.1 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Dynamin_N PF00350.18 KOG99983.1 - 0.016 15.0 6.1 1.6 8.4 0.0 4.0 3 1 0 4 4 3 0 Dynamin family Sigma54_activ_2 PF14532.1 KOG99983.1 - 0.02 14.9 0.0 5.9 6.9 0.0 2.8 2 0 0 2 2 2 0 Sigma-54 interaction domain NB-ARC PF00931.17 KOG99983.1 - 0.028 13.3 0.0 2.9 6.6 0.0 3.0 2 1 0 2 2 2 0 NB-ARC domain DUF87 PF01935.12 KOG99983.1 - 0.055 13.2 1.4 18 5.0 0.0 3.5 3 1 1 4 4 4 0 Domain of unknown function DUF87 G-alpha PF00503.15 KOG99983.1 - 0.055 12.1 3.3 3.5 6.2 0.0 3.3 4 0 0 4 4 4 0 G-protein alpha subunit FeoB_N PF02421.13 KOG99983.1 - 0.061 12.5 0.1 2.7 7.2 0.0 2.7 3 0 0 3 3 3 0 Ferrous iron transport protein B NTPase_1 PF03266.10 KOG99983.1 - 0.071 12.8 1.3 1.8 8.2 0.1 2.9 3 0 0 3 3 2 0 NTPase FtsK_SpoIIIE PF01580.13 KOG99983.1 - 0.073 12.5 0.0 3.1 7.2 0.0 2.8 2 1 1 3 3 3 0 FtsK/SpoIIIE family HAD_2 PF13419.1 KOG99984.1 - 8.7e-20 71.6 0.1 1.2e-19 71.1 0.1 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOG99984.1 - 0.00023 21.6 0.0 0.084 13.2 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Nse5 PF08691.5 KOG99985.1 - 3.7e-58 197.2 24.7 4.4e-58 197.0 17.1 1.0 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 UAA PF08449.6 KOG99986.1 - 3.1e-15 55.8 22.3 3.9e-15 55.5 15.5 1.1 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOG99986.1 - 1.3e-08 34.5 6.1 1.3e-08 34.5 4.2 2.9 1 1 2 3 3 3 1 Triose-phosphate Transporter family EamA PF00892.15 KOG99986.1 - 1.5e-05 25.0 27.0 0.0065 16.4 4.6 2.2 2 0 0 2 2 2 2 EamA-like transporter family PHO4 PF01384.15 KOG99986.1 - 0.043 12.4 9.8 0.014 14.1 1.3 2.8 2 1 0 2 2 2 0 Phosphate transporter family GATA PF00320.22 KOG99987.1 - 7.4e-16 57.1 3.3 7.4e-16 57.1 2.3 2.3 2 0 0 2 2 2 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 KOG99987.1 - 0.16 11.2 0.6 0.35 10.2 0.4 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding XPG_I PF00867.13 KOG99988.1 - 8e-20 70.6 0.0 2.3e-19 69.2 0.0 1.9 1 0 0 1 1 1 1 XPG I-region DUF1669 PF07894.7 KOG99988.1 - 0.071 12.2 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1669) PMSR PF01625.16 KOG99989.1 - 2e-50 170.6 0.1 2.7e-50 170.3 0.1 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase AdoHcyase PF05221.12 KOG99990.1 - 9.6e-142 470.6 0.0 1.1e-141 470.4 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 KOG99990.1 - 2.8e-85 284.1 2.7 4.4e-85 283.5 1.9 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 KOG99990.1 - 1.3e-06 27.6 0.1 2.4e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.13 KOG99990.1 - 0.0005 20.0 0.1 0.00098 19.1 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain IlvN PF07991.7 KOG99990.1 - 0.0013 18.1 0.3 0.0023 17.3 0.2 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain Erg28 PF03694.8 KOG99991.1 - 1.5e-45 153.7 2.0 1.8e-45 153.4 1.4 1.1 1 0 0 1 1 1 1 Erg28 like protein MtN3_slv PF03083.11 KOG99991.1 - 0.00061 19.6 1.1 0.0014 18.4 0.4 1.9 1 1 1 2 2 2 1 Sugar efflux transporter for intercellular exchange Mei4 PF13971.1 KOG99992.1 - 2e-49 168.5 9.2 2.4e-49 168.3 6.4 1.0 1 0 0 1 1 1 1 Meiosis-specific protein Mei4 bZIP_1 PF00170.16 KOG99993.1 - 1.5e-16 60.0 10.8 2.9e-16 59.1 7.5 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 KOG99993.1 - 1.3e-06 28.1 7.0 3.6e-06 26.7 4.8 1.7 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 KOG99993.1 - 0.013 15.7 5.1 0.04 14.2 3.6 1.7 1 0 0 1 1 1 0 bZIP Maf transcription factor Pex24p PF06398.6 KOG99994.1 - 0.2 10.4 4.5 0.24 10.1 3.1 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin AAA PF00004.24 KOG99995.1 - 1.5e-39 135.2 0.0 3.3e-39 134.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 KOG99995.1 - 4.5e-06 26.4 0.0 6.2e-05 22.8 0.0 2.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.1 KOG99995.1 - 1.8e-05 24.8 0.1 0.00029 20.9 0.1 2.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOG99995.1 - 7.4e-05 21.9 0.0 0.00014 20.9 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 KOG99995.1 - 8.6e-05 22.5 0.2 0.0004 20.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 KOG99995.1 - 0.00016 21.7 0.1 0.012 15.6 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.1 KOG99995.1 - 0.00069 19.0 0.2 0.26 10.6 0.0 2.5 1 1 1 2 2 2 2 AAA domain TIP49 PF06068.8 KOG99995.1 - 0.00091 18.0 0.0 0.0016 17.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_5 PF07728.9 KOG99995.1 - 0.0015 18.3 1.3 0.0043 16.7 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 KOG99995.1 - 0.0028 16.8 0.1 0.0094 15.1 0.1 1.9 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 KOG99995.1 - 0.0035 16.7 0.0 0.0074 15.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 KOG99995.1 - 0.004 17.0 1.1 0.023 14.6 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 KOG99995.1 - 0.012 15.3 0.0 0.037 13.7 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain AAA_33 PF13671.1 KOG99995.1 - 0.013 15.3 0.0 0.04 13.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 KOG99995.1 - 0.015 14.2 0.0 0.031 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_28 PF13521.1 KOG99995.1 - 0.028 14.4 0.2 0.19 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Chromo PF00385.19 KOG99995.1 - 0.038 13.6 0.0 0.1 12.2 0.0 1.7 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain AAA_18 PF13238.1 KOG99995.1 - 0.054 13.7 2.4 0.31 11.3 0.0 2.9 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.1 KOG99995.1 - 0.15 12.8 0.0 0.15 12.8 0.0 3.2 4 1 0 4 4 3 0 AAA domain DnaJ-X PF14308.1 KOG99996.1 - 2.2e-60 203.4 9.6 4.1e-60 202.5 6.7 1.4 1 0 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.26 KOG99996.1 - 2e-24 85.1 1.1 2e-24 85.1 0.8 3.3 4 1 0 4 4 4 1 DnaJ domain Complex1_LYR_1 PF13232.1 KOG99997.1 - 2.4e-18 66.0 0.4 3e-18 65.7 0.3 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 KOG99997.1 - 2.9e-18 65.4 0.4 3.7e-18 65.0 0.3 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) MIF4G PF02854.14 KOG99997.1 - 0.017 14.5 0.3 0.018 14.4 0.2 1.1 1 0 0 1 1 1 0 MIF4G domain DUF1851 PF08906.6 KOG99997.1 - 0.11 12.5 0.1 0.18 11.7 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1851) DUF368 PF04018.8 KOG99997.1 - 0.11 11.6 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF368) DUF3038 PF11237.3 KOG99997.1 - 0.15 11.8 0.4 0.17 11.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3038) Ofd1_CTDD PF10637.4 KOG99998.1 - 8.9e-98 326.6 2.0 8.8e-94 313.5 1.6 2.3 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_3 PF13640.1 KOG99998.1 - 3.9e-15 56.1 0.1 1.3e-14 54.5 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Ribosomal_S18 PF01084.15 KOG99999.1 - 1.3e-14 53.8 0.2 2.2e-14 53.0 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 Cupin_8 PF13621.1 KOH00001.1 - 4.8e-07 29.5 3.3 9.1e-07 28.6 2.3 1.5 1 1 0 1 1 1 1 Cupin-like domain PHD PF00628.24 KOH00001.1 - 1.7e-05 24.4 2.4 3.6e-05 23.3 1.6 1.6 1 0 0 1 1 1 1 PHD-finger JmjC PF02373.17 KOH00001.1 - 0.00031 20.9 0.2 0.16 12.1 0.0 3.8 3 1 0 3 3 3 1 JmjC domain, hydroxylase C1_1 PF00130.17 KOH00001.1 - 0.01 15.5 5.6 0.023 14.4 3.9 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF1423 PF07227.6 KOH00001.1 - 0.014 14.0 2.0 0.031 12.9 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) Cupin_4 PF08007.7 KOH00001.1 - 0.026 13.8 0.0 0.054 12.7 0.0 1.5 1 0 0 1 1 1 0 Cupin superfamily protein Cupin_2 PF07883.6 KOH00001.1 - 0.057 12.9 0.0 0.22 11.0 0.0 1.9 2 0 0 2 2 2 0 Cupin domain AA_kinase PF00696.23 KOH00002.1 - 7.5e-41 140.2 0.0 1.1e-40 139.7 0.0 1.2 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.20 KOH00002.1 - 4.4e-13 48.4 0.7 5.8e-07 28.8 0.1 3.2 3 0 0 3 3 3 2 ACT domain ACT_7 PF13840.1 KOH00002.1 - 3e-09 36.2 1.2 4.1e-07 29.4 0.2 2.5 2 0 0 2 2 2 2 ACT domain Mito_carr PF00153.22 KOH00003.1 - 1.8e-47 158.9 6.5 3.7e-17 61.7 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2254 PF10011.4 KOH00004.1 - 0.14 10.6 0.1 0.14 10.6 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) CBM_21 PF03370.8 KOH00005.1 - 2.8e-30 104.5 2.1 7.4e-30 103.2 0.5 2.4 3 0 0 3 3 3 1 Putative phosphatase regulatory subunit CBM_25 PF03423.8 KOH00005.1 - 0.52 10.4 5.5 6.8 6.8 0.4 3.5 3 0 0 3 3 3 0 Carbohydrate binding domain (family 25) HisG PF01634.13 KOH00006.1 - 9e-53 178.1 0.2 1.2e-52 177.7 0.1 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.6 KOH00006.1 - 1.4e-26 92.1 0.0 2.5e-26 91.4 0.0 1.4 1 0 0 1 1 1 1 HisG, C-terminal domain Transp_cyt_pur PF02133.10 KOH00007.1 - 2.6e-116 388.7 45.1 3e-116 388.5 31.3 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Ribonuc_L-PSP PF01042.16 KOH00008.1 - 4.6e-43 145.8 0.9 5.2e-43 145.6 0.6 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF4488 PF14869.1 KOH00008.1 - 0.025 14.1 0.1 0.032 13.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4488) Mg_chelatase_2 PF13335.1 KOH00008.1 - 0.11 12.9 0.0 0.16 12.4 0.0 1.4 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF896 PF05979.7 KOH00009.1 - 4.1 7.0 6.1 1.4 8.6 1.7 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) Cyclin PF08613.6 KOH00010.1 - 2.7e-44 151.1 0.2 7.3e-25 88.1 0.0 2.7 2 0 0 2 2 2 2 Cyclin Transp_cyt_pur PF02133.10 KOH00011.1 - 5.6e-118 394.2 42.9 6.8e-118 393.9 29.7 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Transp_cyt_pur PF02133.10 KOH00012.1 - 2.1e-115 385.8 43.4 2.4e-115 385.6 30.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin ketoacyl-synt PF00109.21 KOH00013.1 - 3.1e-56 190.6 0.0 8.1e-56 189.3 0.0 1.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 KOH00013.1 - 6.4e-34 116.3 0.1 1e-33 115.6 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 KOH00013.1 - 0.0094 14.9 0.3 0.019 13.9 0.1 1.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain HAD_2 PF13419.1 KOH00014.1 - 9.2e-14 52.0 0.0 1.2e-13 51.6 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOH00014.1 - 1.5e-08 35.3 0.0 3.2e-08 34.2 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOH00014.1 - 4.3e-07 29.5 0.0 7.8e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.2 KOH00014.1 - 0.0026 17.9 0.0 0.0035 17.5 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase SAP PF02037.22 KOH00015.1 - 2.6e-12 45.9 0.5 4.3e-12 45.2 0.3 1.4 1 0 0 1 1 1 1 SAP domain Vhr1 PF04001.8 KOH00016.1 - 6.4e-50 167.0 1.1 1.3e-49 166.0 0.8 1.5 1 0 0 1 1 1 1 Transcription factor Vhr1 ABC_tran_2 PF12848.2 KOH00016.1 - 1.3 8.8 4.3 0.48 10.3 0.1 2.1 1 1 1 2 2 2 0 ABC transporter ICL PF00463.16 KOH00017.1 - 2e-287 953.5 0.2 2.3e-287 953.3 0.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 KOH00017.1 - 4.6e-10 39.1 0.0 8.8e-10 38.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Terpene_synth_C PF03936.11 KOH00017.1 - 0.065 12.4 0.1 0.23 10.6 0.0 2.0 2 0 0 2 2 2 0 Terpene synthase family, metal binding domain Arg_repressor_C PF02863.13 KOH00017.1 - 0.12 11.8 0.1 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain DUF2578 PF10843.3 KOH00018.1 - 1.4e-65 220.6 15.1 1.6e-65 220.4 10.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2578) DIX PF00778.12 KOH00018.1 - 0.0013 18.4 3.0 0.0018 17.9 0.4 2.3 2 0 0 2 2 2 1 DIX domain zf-RING_4 PF14570.1 KOH00019.1 - 5.5e-20 70.6 13.5 1e-19 69.8 9.4 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_5 PF13893.1 KOH00019.1 - 2e-07 30.7 0.4 9.5e-07 28.5 0.3 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rtf2 PF04641.7 KOH00019.1 - 9.3e-07 28.2 0.8 2e-06 27.2 0.5 1.5 1 0 0 1 1 1 1 Rtf2 RING-finger zf-C3HC4_3 PF13920.1 KOH00019.1 - 5.2e-06 26.0 6.7 1.1e-05 25.0 4.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.17 KOH00019.1 - 5.6e-06 25.9 0.1 0.00014 21.4 0.0 2.4 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Baculo_IE-1 PF05290.6 KOH00019.1 - 4.2e-05 23.3 3.0 9.3e-05 22.1 2.1 1.5 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_2 PF13639.1 KOH00019.1 - 0.0014 18.3 8.9 0.0033 17.2 6.2 1.6 1 0 0 1 1 1 1 Ring finger domain RRM_6 PF14259.1 KOH00019.1 - 0.0028 17.6 0.1 0.0092 15.9 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4 PF00097.20 KOH00019.1 - 0.007 15.9 10.9 0.016 14.8 7.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SET_assoc PF11767.3 KOH00019.1 - 0.011 15.0 0.0 0.025 13.8 0.0 1.5 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated PocR PF10114.4 KOH00019.1 - 0.022 13.9 0.8 0.25 10.4 0.3 2.4 2 0 0 2 2 2 0 Sensory domain found in PocR zf-UDP PF14569.1 KOH00019.1 - 0.13 12.0 5.5 0.29 10.9 3.8 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_5 PF14634.1 KOH00019.1 - 0.15 11.7 9.5 0.33 10.7 6.6 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KOH00019.1 - 0.68 10.0 11.2 1.4 8.9 7.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KOH00019.1 - 2.5 8.0 11.7 16 5.4 7.7 2.6 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING DUF619 PF04768.8 KOH00020.1 - 1.1e-51 174.5 0.3 3.1e-51 173.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF619) Semialdhyde_dh PF01118.19 KOH00020.1 - 1.2e-30 106.3 0.0 2.4e-30 105.3 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.23 KOH00020.1 - 9.8e-18 64.5 0.1 2e-17 63.5 0.1 1.5 1 0 0 1 1 1 1 Amino acid kinase family DapB_N PF01113.15 KOH00020.1 - 0.0076 16.1 0.0 0.021 14.7 0.0 1.8 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Ribonuc_red_lgC PF02867.10 KOH00021.1 - 5.7e-216 718.2 0.0 8.4e-216 717.6 0.0 1.3 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 KOH00021.1 - 1.9e-23 82.0 0.0 5.2e-23 80.6 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 KOH00021.1 - 2.3e-15 56.7 0.1 1.4e-14 54.2 0.0 2.5 2 0 0 2 2 2 1 ATP cone domain Tctex-1 PF03645.8 KOH00022.1 - 3.2e-06 26.9 0.0 4.3e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Tctex-1 family Phage_Integr_2 PF13009.1 KOH00022.1 - 0.038 12.9 0.1 0.048 12.5 0.1 1.1 1 0 0 1 1 1 0 Putative phage integrase DUF202 PF02656.10 KOH00023.1 - 3e-13 49.7 2.8 3e-13 49.7 1.9 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) LHC PF00556.15 KOH00023.1 - 0.011 15.5 0.1 0.037 13.8 0.0 1.9 1 0 0 1 1 1 0 Antenna complex alpha/beta subunit DUF2207 PF09972.4 KOH00023.1 - 5.1 5.5 6.1 19 3.6 4.4 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Aldedh PF00171.17 KOH00024.1 - 2.9e-185 616.0 0.7 3.3e-185 615.8 0.5 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 KOH00024.1 - 0.00016 20.5 0.0 0.00032 19.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) CN_hydrolase PF00795.17 KOH00024.1 - 0.036 13.4 0.0 0.066 12.5 0.0 1.4 1 0 0 1 1 1 0 Carbon-nitrogen hydrolase TPR_12 PF13424.1 KOH00024.1 - 0.17 11.8 0.1 0.46 10.4 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Ribosomal_S24e PF01282.14 KOH00025.1 - 2.5e-35 120.1 0.2 3.8e-35 119.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e RAMPs PF03787.10 KOH00025.1 - 0.017 14.9 0.5 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 RAMP superfamily SeleniumBinding PF11524.3 KOH00025.1 - 0.025 14.6 0.0 0.045 13.8 0.0 1.4 1 0 0 1 1 1 0 Selenium binding protein Yos1 PF08571.5 KOH00026.1 - 8.8e-17 60.9 0.2 9.3e-17 60.9 0.2 1.0 1 0 0 1 1 1 1 Yos1-like TMEM191C PF15194.1 KOH00026.1 - 0.05 13.4 0.0 0.051 13.4 0.0 1.0 1 0 0 1 1 1 0 TMEM191C family Y_phosphatase PF00102.22 KOH00027.1 - 5.9e-49 166.5 0.0 9.5e-48 162.5 0.0 2.2 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.15 KOH00027.1 - 5.9e-11 42.7 0.0 2e-10 41.0 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.15 KOH00027.1 - 0.0024 17.4 0.0 0.0096 15.5 0.0 2.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DUF4622 PF15415.1 KOH00027.1 - 0.013 14.2 0.0 0.045 12.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4622) Y_phosphatase3 PF13350.1 KOH00027.1 - 0.08 13.1 0.5 0.22 11.7 0.0 1.9 2 0 0 2 2 2 0 Tyrosine phosphatase family PPR_2 PF13041.1 KOH00028.1 - 9.9e-14 51.0 3.9 5.6e-11 42.2 0.0 3.9 4 0 0 4 4 4 2 PPR repeat family Peptidase_M24 PF00557.19 KOH00029.1 - 4.9e-49 166.7 0.0 6.6e-49 166.3 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 KOH00029.1 - 4.5e-31 107.0 0.0 1.9e-30 105.0 0.0 2.0 3 0 0 3 3 3 1 Aminopeptidase P, N-terminal domain APH PF01636.18 KOH00031.1 - 2.8e-07 30.5 0.0 2.8e-06 27.2 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 KOH00031.1 - 0.085 11.9 0.0 8.4 5.3 0.0 2.6 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family 2-Hacid_dh_C PF02826.14 KOH00032.1 - 9.1e-52 174.7 0.0 1.5e-51 174.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 KOH00032.1 - 7.4e-38 129.0 0.0 1e-37 128.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 KOH00032.1 - 9.3e-06 25.5 1.5 1.4e-05 25.0 0.2 1.9 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.16 KOH00032.1 - 0.0003 20.6 0.0 0.0006 19.6 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Acetyltransf_1 PF00583.19 KOH00032.1 - 0.0025 17.8 0.0 0.016 15.2 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family ACT PF01842.20 KOH00032.1 - 0.015 14.7 0.0 0.05 13.1 0.0 1.8 1 0 0 1 1 1 0 ACT domain DUF4367 PF14285.1 KOH00032.1 - 0.02 14.2 0.0 0.02 14.2 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4367) DUF262 PF03235.9 KOH00032.1 - 0.024 14.6 0.1 0.04 13.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF262 3HCDH_N PF02737.13 KOH00032.1 - 0.087 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.1 KOH00032.1 - 0.098 12.9 0.0 0.37 11.1 0.0 1.9 2 0 0 2 2 2 0 XdhC Rossmann domain BING4CT PF08149.6 KOH00033.1 - 9.8e-39 130.7 0.0 1.1e-36 124.2 0.0 3.5 4 0 0 4 4 4 1 BING4CT (NUC141) domain WD40 PF00400.27 KOH00033.1 - 3.7e-06 26.6 0.0 0.00018 21.2 0.0 3.4 3 0 0 3 3 3 1 WD domain, G-beta repeat GET2 PF08690.5 KOH00034.1 - 2e-101 339.2 1.3 2.1e-100 335.8 0.9 1.9 1 1 0 1 1 1 1 GET complex subunit GET2 Clathrin-link PF09268.5 KOH00035.1 - 0.27 10.3 1.5 0.36 9.9 0.3 1.8 2 0 0 2 2 2 0 Clathrin, heavy-chain linker PALP PF00291.20 KOH00036.1 - 6.7e-74 248.8 0.2 9.1e-74 248.4 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.13 KOH00036.1 - 1.2e-42 143.3 0.0 3.5e-29 100.2 0.0 2.6 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Alpha-2-MRAP_N PF06400.6 KOH00036.1 - 0.039 13.6 0.2 0.071 12.7 0.1 1.4 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, N-terminal domain tRNA-synt_2b PF00587.20 KOH00037.1 - 1.8e-32 112.3 0.0 4.1e-32 111.1 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KOH00037.1 - 0.0087 15.9 0.0 0.02 14.8 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain A2L_zn_ribbon PF08792.5 KOH00037.1 - 0.19 11.2 2.8 14 5.2 0.1 3.2 3 0 0 3 3 3 0 A2L zinc ribbon domain Sec61_beta PF03911.11 KOH00038.1 - 7.9e-17 60.7 0.8 9.7e-17 60.5 0.5 1.1 1 0 0 1 1 1 1 Sec61beta family Myb_DNA-bind_6 PF13921.1 KOH00039.1 - 6.2e-12 45.4 1.2 1.8e-09 37.5 0.2 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 KOH00039.1 - 4e-09 36.3 0.8 2.6e-07 30.5 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain PP2C PF00481.16 KOH00041.1 - 1.1e-82 277.2 0.0 1.7e-82 276.6 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Chorismate_bind PF00425.13 KOH00042.1 - 6.3e-87 291.1 0.0 4.9e-86 288.2 0.0 2.0 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.8 KOH00042.1 - 3.7e-31 108.0 0.1 9.5e-29 100.2 0.0 3.4 2 1 0 2 2 2 1 Anthranilate synthase component I, N terminal region POR PF01558.13 KOH00042.1 - 0.071 13.0 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase RNase_P_pop3 PF08228.6 KOH00042.1 - 0.13 12.0 0.1 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 RNase P subunit Pop3 Meth_synt_2 PF01717.13 KOH00043.1 - 2.1e-144 480.4 0.0 1.2e-139 464.8 0.0 2.4 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 KOH00043.1 - 1.1e-128 428.8 0.0 1.1e-114 382.9 0.0 3.1 3 0 0 3 3 3 3 Cobalamin-independent synthase, N-terminal domain EzrA PF06160.7 KOH00044.1 - 0.07 11.2 0.5 0.087 10.9 0.4 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA TelA PF05816.6 KOH00044.1 - 0.11 11.1 0.4 0.18 10.5 0.3 1.3 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) RICTOR_N PF14664.1 KOH00045.1 - 1.1e-107 359.8 10.3 2e-107 358.9 7.1 1.5 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.1 KOH00045.1 - 1.4e-76 256.4 2.6 1.4e-76 256.4 1.8 3.6 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.1 KOH00045.1 - 1.5e-32 111.9 0.7 6.4e-32 109.8 0.1 2.5 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.1 KOH00045.1 - 7.4e-31 105.9 0.5 1.4e-29 101.8 0.1 3.2 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 DUF1664 PF07889.7 KOH00045.1 - 0.19 11.5 3.1 0.34 10.7 0.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Proteasome PF00227.21 KOH00046.1 - 1.2e-40 138.7 0.0 1.5e-40 138.5 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Asp PF00026.18 KOH00046.1 - 0.08 12.1 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic aspartyl protease Rad51 PF08423.6 KOH00047.1 - 3.3e-136 452.2 0.0 4.2e-136 451.8 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 KOH00047.1 - 3.6e-13 49.3 0.0 5.6e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.1 KOH00047.1 - 2.4e-11 43.6 1.7 6.3e-11 42.2 1.2 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain RecA PF00154.16 KOH00047.1 - 3.6e-11 42.6 0.0 5.3e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 KOH00047.1 - 4.8e-06 25.8 0.0 8.6e-06 25.0 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.1 KOH00047.1 - 0.022 14.9 0.0 0.042 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.10 KOH00047.1 - 0.061 12.2 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Ribosomal_60s PF00428.14 KOH00047.1 - 0.91 9.9 5.1 0.72 10.2 0.8 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Sel1 PF08238.7 KOH00048.1 - 4e-20 71.7 0.1 0.00012 22.5 0.0 4.6 4 0 0 4 4 4 4 Sel1 repeat UCH PF00443.24 KOH00049.1 - 2.1e-85 286.1 14.3 4.3e-85 285.0 9.9 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOH00049.1 - 6.1e-24 84.9 13.9 4.6e-20 72.2 0.6 3.1 2 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Pribosyltran_N PF13793.1 KOH00050.1 - 1.7e-43 146.9 0.0 2.6e-40 136.7 0.0 2.3 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 KOH00050.1 - 3.5e-36 124.6 1.8 1.2e-29 103.3 0.5 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 KOH00050.1 - 4.2e-14 52.3 0.3 8e-13 48.2 0.3 2.3 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.1 KOH00050.1 - 0.0034 16.6 0.1 0.0049 16.1 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase UQ_con PF00179.21 KOH00051.1 - 3.1e-28 97.9 0.2 5.3e-28 97.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 KOH00051.1 - 0.0088 15.9 0.1 0.021 14.7 0.1 1.7 1 0 0 1 1 1 1 RWD domain ADH_zinc_N_2 PF13602.1 KOH00052.1 - 6.3e-12 46.4 0.0 1.3e-11 45.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOH00052.1 - 7.2e-06 25.7 0.0 1.3e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOH00052.1 - 0.0043 16.6 0.0 0.4 10.2 0.0 2.5 2 0 0 2 2 2 2 Zinc-binding dehydrogenase Ribosomal_S8e PF01201.17 KOH00053.1 - 7.4e-51 171.7 2.6 8.5e-51 171.5 1.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e HSP70 PF00012.15 KOH00054.1 - 1.6e-269 894.9 11.0 1.8e-269 894.7 7.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOH00054.1 - 2.2e-18 65.9 0.0 2.8e-17 62.3 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 KOH00054.1 - 0.00011 21.9 0.0 0.00023 20.8 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.5 KOH00054.1 - 0.033 13.0 0.4 0.51 9.1 0.1 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.13 KOH00054.1 - 0.041 12.9 2.6 0.051 12.6 0.1 2.4 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase CAF-1_p150 PF11600.3 KOH00055.1 - 0.25 10.7 11.9 0.36 10.1 8.3 1.3 1 1 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal SOBP PF15279.1 KOH00055.1 - 1.4 9.2 6.9 1.7 8.9 4.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Nucleoporin_C PF03177.9 KOH00056.1 - 2.4e-97 326.8 5.3 3.2e-97 326.4 3.7 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 KOH00056.1 - 6.7e-91 305.1 14.3 9.1e-91 304.6 7.7 2.1 2 0 0 2 2 2 1 Nup133 N terminal like DUF1955 PF09205.5 KOH00056.1 - 0.051 13.0 2.6 0.7 9.3 0.0 3.8 5 1 0 6 6 6 0 Domain of unknown function (DUF1955) MAM1 PF10434.4 KOH00057.1 - 8.3e-75 251.4 21.5 8.3e-75 251.4 14.9 1.4 2 0 0 2 2 2 1 Monopolin complex protein MAM1 Curto_V2 PF07325.6 KOH00057.1 - 2.8 7.6 7.0 1.7 8.3 1.3 2.8 1 1 2 3 3 3 0 Curtovirus V2 protein WD40 PF00400.27 KOH00058.1 - 2.8e-26 90.3 4.1 4e-05 23.3 0.0 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.3 KOH00058.1 - 0.021 12.9 0.2 0.1 10.7 0.0 1.9 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Rrn6 PF10214.4 KOH00058.1 - 0.43 8.6 2.0 3.2 5.7 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor LisH PF08513.6 KOH00059.1 - 9.9e-06 25.1 0.1 1.9e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 LisH BAF1_ABF1 PF04684.8 KOH00059.1 - 0.021 13.7 11.7 0.042 12.7 8.1 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor HEAT_EZ PF13513.1 KOH00060.1 - 1.4e-18 66.8 0.1 0.0017 18.8 0.0 8.9 9 0 0 9 9 9 4 HEAT-like repeat HEAT_2 PF13646.1 KOH00060.1 - 1.8e-14 53.7 2.4 0.0023 18.2 0.0 6.7 5 2 2 7 7 7 5 HEAT repeats IBN_N PF03810.14 KOH00060.1 - 2.3e-14 53.0 2.4 1.3e-09 37.8 0.0 4.8 4 0 0 4 4 4 2 Importin-beta N-terminal domain HEAT PF02985.17 KOH00060.1 - 6e-13 47.7 2.7 0.045 13.8 0.0 9.3 10 0 0 10 10 10 2 HEAT repeat Ipi1_N PF12333.3 KOH00060.1 - 0.047 13.6 1.8 2.7 8.0 0.0 4.8 6 1 1 7 7 7 0 Rix1 complex component involved in 60S ribosome maturation Cnd1 PF12717.2 KOH00060.1 - 0.061 13.1 11.7 0.8 9.5 0.2 5.2 3 3 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Ank PF00023.25 KOH00061.1 - 7e-10 38.2 3.0 0.00064 19.4 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 KOH00061.1 - 2.9e-08 33.9 3.2 0.0048 17.2 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOH00061.1 - 1.4e-07 31.8 3.3 0.0075 16.7 0.1 3.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) KilA-N PF04383.8 KOH00061.1 - 2.4e-07 30.3 0.7 2.4e-07 30.3 0.5 5.1 4 1 0 4 4 4 1 KilA-N domain Ank_3 PF13606.1 KOH00061.1 - 4e-06 26.5 0.9 0.087 13.1 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOH00061.1 - 0.00023 21.2 1.5 0.33 11.2 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) LSM PF01423.17 KOH00062.1 - 5.8e-16 57.7 0.2 5.8e-16 57.7 0.1 1.7 2 0 0 2 2 2 1 LSM domain SM-ATX PF14438.1 KOH00062.1 - 8.2e-05 22.4 0.0 0.00021 21.1 0.0 1.7 1 0 0 1 1 1 1 Ataxin 2 SM domain EMP70 PF02990.11 KOH00063.1 - 1.3e-171 571.6 15.8 1.6e-171 571.3 11.0 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 EphA2_TM PF14575.1 KOH00063.1 - 0.052 13.9 2.9 5.2 7.5 0.0 3.9 3 1 1 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain PH PF00169.24 KOH00064.1 - 3.1e-14 53.0 2.5 5.4e-14 52.2 0.0 2.7 2 1 0 2 2 2 1 PH domain SH3_1 PF00018.23 KOH00064.1 - 1.4e-12 46.7 0.2 2.9e-12 45.7 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SAM_2 PF07647.12 KOH00064.1 - 2.7e-11 43.1 0.0 5.7e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_11 PF15413.1 KOH00064.1 - 8e-09 35.7 0.0 3.9e-08 33.5 0.0 2.3 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_9 PF14604.1 KOH00064.1 - 1.1e-06 28.0 0.1 2.1e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_8 PF15409.1 KOH00064.1 - 0.00043 20.3 0.0 0.011 15.7 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain SAM_1 PF00536.25 KOH00064.1 - 0.0013 18.8 0.1 0.0028 17.7 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.12 KOH00064.1 - 0.0013 18.1 0.0 0.0029 17.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain zf-C3HC4 PF00097.20 KOH00066.1 - 3.4e-07 29.8 14.4 6.6e-07 28.8 10.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOH00066.1 - 1.1e-06 28.3 14.8 2.4e-06 27.2 10.3 1.6 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOH00066.1 - 3.8e-06 26.4 13.1 8e-06 25.4 9.1 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOH00066.1 - 1.6e-05 24.8 11.5 4.6e-05 23.3 8.2 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOH00066.1 - 4.4e-05 23.0 8.4 0.00011 21.8 5.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 KOH00066.1 - 0.00052 19.6 14.1 0.0021 17.7 9.9 1.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 KOH00066.1 - 0.07 13.0 15.1 0.16 11.8 10.4 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 KOH00066.1 - 5.7 7.1 9.9 17 5.5 6.9 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger Ribosomal_L14 PF00238.14 KOH00067.1 - 8.1e-32 109.5 0.0 9e-32 109.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e SH3_1 PF00018.23 KOH00068.1 - 3.2e-12 45.6 0.2 5.9e-12 44.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOH00068.1 - 9.2e-11 41.1 0.1 1.5e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOH00068.1 - 8.3e-08 31.6 0.0 1.7e-07 30.5 0.0 1.6 1 1 0 1 1 1 1 Variant SH3 domain Aa_trans PF01490.13 KOH00069.1 - 1.6e-118 395.7 27.9 1.9e-118 395.5 19.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 KOH00069.1 - 2.4e-09 36.4 15.9 2.4e-09 36.4 11.0 1.7 1 1 1 2 2 2 1 Tryptophan/tyrosine permease family SHR3_chaperone PF08229.6 KOH00069.1 - 0.16 10.8 2.0 0.2 10.5 0.2 2.1 2 0 0 2 2 2 0 ER membrane protein SH3 Motile_Sperm PF00635.21 KOH00070.1 - 1.3e-26 92.4 0.4 3e-26 91.1 0.0 1.8 2 0 0 2 2 2 1 MSP (Major sperm protein) domain ArfGap PF01412.13 KOH00071.1 - 2.1e-33 114.5 0.5 2.1e-33 114.5 0.4 2.4 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf SOBP PF15279.1 KOH00071.1 - 6.7 7.0 11.3 9.8 6.4 7.8 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Pkinase PF00069.20 KOH00072.1 - 4.7e-27 94.7 0.5 1e-26 93.6 0.0 1.8 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00072.1 - 7.8e-07 28.4 0.0 1.4e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3354 PF11834.3 KOH00072.1 - 0.093 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3354) WD40 PF00400.27 KOH00073.1 - 0.0075 16.1 1.6 5.8 6.9 0.0 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat HECT PF00632.20 KOH00074.1 - 9.7e-91 304.2 0.0 1.3e-90 303.7 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.21 KOH00074.1 - 5e-34 115.7 19.7 6.7e-11 41.8 1.0 3.8 3 0 0 3 3 3 3 WW domain C2 PF00168.25 KOH00074.1 - 4.3e-16 58.5 0.3 1.1e-15 57.2 0.2 1.7 1 0 0 1 1 1 1 C2 domain Ribosomal_S8e PF01201.17 KOH00075.1 - 2.5e-38 131.1 6.8 5.9e-38 129.9 4.7 1.6 1 1 0 1 1 1 1 Ribosomal protein S8e HPD PF05044.7 KOH00075.1 - 0.037 13.7 0.1 0.073 12.7 0.1 1.4 1 0 0 1 1 1 0 Homeo-prospero domain YebF PF13995.1 KOH00075.1 - 0.065 13.2 0.2 0.18 11.8 0.0 1.8 2 0 0 2 2 2 0 YebF-like protein Sas10_Utp3 PF04000.10 KOH00076.1 - 2e-11 43.8 1.0 2e-11 43.8 0.7 2.3 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Syntaxin_2 PF14523.1 KOH00076.1 - 0.69 9.9 10.2 0.57 10.2 0.2 3.1 3 0 0 3 3 3 0 Syntaxin-like protein Sec2p PF06428.6 KOH00076.1 - 5.7 6.8 10.8 0.062 13.1 1.1 2.5 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p DUF2762 PF10960.3 KOH00076.1 - 6.3 6.5 6.4 16 5.3 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2762) Vfa1 PF08432.5 KOH00077.1 - 7.7e-45 153.1 4.0 8.8e-45 152.9 2.8 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 BCIP PF13862.1 KOH00077.1 - 0.0045 16.5 1.9 0.0045 16.5 1.3 1.6 2 0 0 2 2 2 1 p21-C-terminal region-binding protein Pkinase PF00069.20 KOH00078.1 - 1.4e-57 194.8 0.1 2.3e-57 194.0 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00078.1 - 4.6e-26 91.4 0.2 2e-25 89.3 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH00078.1 - 6.7e-06 25.2 0.0 1.3e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like zf-C2H2 PF00096.21 KOH00079.1 - 1e-11 44.4 16.5 3.8e-06 26.8 2.3 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOH00079.1 - 3.2e-09 36.4 12.7 0.00011 22.2 1.5 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOH00079.1 - 2.5e-07 30.6 9.1 0.0031 17.6 0.8 2.9 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KOH00079.1 - 4.3e-07 29.9 7.1 0.0047 17.0 0.1 2.9 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.1 KOH00079.1 - 6.4e-05 23.0 21.1 0.00022 21.3 4.8 3.5 3 0 0 3 3 3 1 Zinc-finger double domain UPF0515 PF15135.1 KOH00079.1 - 0.011 14.8 1.4 0.029 13.4 1.0 1.9 1 1 0 1 1 1 0 Uncharacterised protein UPF0515 zf-C2H2_6 PF13912.1 KOH00079.1 - 0.023 14.5 0.8 0.023 14.5 0.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.7 KOH00079.1 - 0.047 13.8 7.0 0.082 13.0 4.8 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.10 KOH00079.1 - 0.062 13.0 9.8 0.59 9.9 2.9 2.6 1 1 1 2 2 2 0 BED zinc finger GAGA PF09237.6 KOH00079.1 - 0.075 12.6 1.1 0.17 11.5 0.8 1.6 1 0 0 1 1 1 0 GAGA factor zf-C2H2_2 PF12756.2 KOH00079.1 - 0.22 11.6 8.3 7.4 6.7 1.8 2.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.1 KOH00079.1 - 8 6.2 9.3 21 4.9 0.3 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Elf1 PF05129.8 KOH00079.1 - 9.2 6.0 10.2 8.4 6.1 2.0 2.4 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like Ribosomal_S26e PF01283.14 KOH00080.1 - 2.5e-50 169.4 8.1 2.9e-50 169.2 5.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e DUF1101 PF06503.6 KOH00080.1 - 0.019 13.7 0.1 0.021 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1101) Kelch_6 PF13964.1 KOH00081.1 - 1.8e-12 46.8 4.4 1.1e-05 25.3 0.0 5.2 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.1 KOH00081.1 - 1.8e-10 40.3 2.2 0.0025 17.5 0.0 5.1 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KOH00081.1 - 2.2e-10 39.9 0.8 0.00021 20.7 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 KOH00081.1 - 1.2e-09 38.0 0.4 0.0075 16.4 0.0 5.4 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KOH00081.1 - 2e-05 24.1 0.8 0.38 10.5 0.0 3.2 2 1 0 2 2 2 2 Kelch motif Kelch_5 PF13854.1 KOH00081.1 - 0.0012 18.7 0.5 0.0049 16.7 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Acid_PPase PF12689.2 KOH00083.1 - 2.6e-41 141.0 0.0 3.1e-41 140.8 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase GDI PF00996.13 KOH00084.1 - 3.3e-219 727.6 0.1 4.2e-219 727.2 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.1 KOH00084.1 - 0.007 16.3 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain ParcG PF10274.4 KOH00085.1 - 0.053 13.4 0.2 0.064 13.1 0.1 1.1 1 0 0 1 1 1 0 Parkin co-regulated protein zf-CCHC PF00098.18 KOH00085.1 - 0.23 11.4 2.7 0.37 10.7 1.9 1.3 1 0 0 1 1 1 0 Zinc knuckle eIF3g PF12353.3 KOH00085.1 - 0.29 11.0 4.0 0.24 11.3 1.3 1.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G DUF3372 PF11852.3 KOH00087.1 - 0.027 13.6 0.4 0.044 12.9 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3372) RPAP2_Rtr1 PF04181.8 KOH00088.1 - 1.4e-20 73.1 0.2 2.3e-20 72.4 0.1 1.4 1 0 0 1 1 1 1 Rtr1/RPAP2 family TraB PF01963.12 KOH00088.1 - 0.028 13.8 0.1 6.2 6.1 0.0 2.1 2 0 0 2 2 2 0 TraB family DUF747 PF05346.6 KOH00089.1 - 9.3e-93 310.8 20.2 1.3e-92 310.3 14.0 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family COX15-CtaA PF02628.10 KOH00090.1 - 1.7e-99 332.5 7.2 2e-99 332.2 5.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Cytochrom_B561 PF03188.11 KOH00090.1 - 0.017 14.9 2.0 0.017 14.9 1.4 2.5 3 1 0 3 3 3 0 Eukaryotic cytochrome b561 HhH-GPD PF00730.20 KOH00091.1 - 4.7e-13 49.3 0.0 8.4e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Asp_protease PF09668.5 KOH00092.1 - 2.5e-50 169.1 0.1 3.9e-50 168.5 0.1 1.3 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 KOH00092.1 - 7.1e-10 39.2 0.2 1.7e-09 38.0 0.2 1.7 1 0 0 1 1 1 1 Aspartyl protease UBA PF00627.26 KOH00092.1 - 1.2e-09 37.6 0.1 5e-09 35.7 0.0 2.1 2 0 0 2 2 2 1 UBA/TS-N domain RVP PF00077.15 KOH00092.1 - 4.4e-08 32.9 0.3 8.9e-08 31.9 0.2 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KOH00092.1 - 2.4e-06 27.2 0.0 5.5e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KOH00092.1 - 4.2e-06 26.7 0.0 8.3e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease UN_NPL4 PF11543.3 KOH00092.1 - 0.0019 18.4 0.0 0.0078 16.4 0.0 2.0 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 UBA_3 PF09288.5 KOH00092.1 - 0.066 12.8 0.4 0.25 10.9 0.0 2.2 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain UCH PF00443.24 KOH00093.1 - 7.3e-66 222.0 1.8 1.1e-65 221.5 1.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOH00093.1 - 2.1e-28 99.6 1.3 3.2e-28 99.0 0.9 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.15 KOH00093.1 - 1.7e-08 34.7 0.0 3.1e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain FTR1 PF03239.9 KOH00094.1 - 2.4e-104 348.5 7.3 2.9e-104 348.2 5.1 1.1 1 0 0 1 1 1 1 Iron permease FTR1 family DUF839 PF05787.8 KOH00094.1 - 0.0083 15.1 0.2 0.012 14.6 0.1 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF839) LSM PF01423.17 KOH00095.1 - 4.9e-18 64.4 0.6 6.7e-18 64.0 0.4 1.2 1 0 0 1 1 1 1 LSM domain Cohesin_load PF10345.4 KOH00096.1 - 2.8e-145 484.9 5.8 3.2e-145 484.7 4.0 1.0 1 0 0 1 1 1 1 Cohesin loading factor TBP PF00352.16 KOH00097.1 - 9.3e-70 230.0 0.4 4.1e-35 119.0 0.0 2.5 3 0 0 3 3 3 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 KOH00097.1 - 0.00017 21.5 1.0 0.62 10.1 0.0 2.9 3 1 1 4 4 4 2 Domain of unknown function (DUF3378) Myosin_tail_1 PF01576.14 KOH00098.1 - 9.9e-05 20.2 8.6 9.9e-05 20.2 6.0 2.2 2 0 0 2 2 2 2 Myosin tail Rab5-bind PF09311.6 KOH00098.1 - 0.0015 18.4 4.4 0.0015 18.4 3.0 2.4 2 0 0 2 2 2 1 Rabaptin-like protein ADIP PF11559.3 KOH00098.1 - 0.0078 16.1 8.5 0.0078 16.1 5.9 2.8 2 1 0 2 2 2 1 Afadin- and alpha -actinin-Binding NYD-SP28_assoc PF14775.1 KOH00098.1 - 0.0098 15.5 1.0 0.0098 15.5 0.7 2.7 3 0 0 3 3 3 1 Sperm tail C-terminal domain TPR_MLP1_2 PF07926.7 KOH00098.1 - 0.56 9.9 20.7 0.83 9.3 5.5 3.4 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Flocculin_t3 PF13928.1 KOH00099.1 - 0.018 15.1 7.6 0.018 15.1 5.3 3.1 1 1 2 3 3 3 0 Flocculin type 3 repeat UCH PF00443.24 KOH00100.1 - 1.2e-55 188.5 3.7 1.2e-55 188.5 2.6 2.2 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Aminotran_1_2 PF00155.16 KOH00101.1 - 2.9e-22 79.1 0.0 3.5e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 KOH00101.1 - 1.9e-05 23.4 0.0 2.3e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase PET122 PF05476.6 KOH00102.1 - 3.1e-109 364.3 0.0 3.8e-109 364.0 0.0 1.0 1 0 0 1 1 1 1 PET122 60KD_IMP PF02096.15 KOH00103.1 - 1.7e-37 129.0 0.8 1.7e-37 129.0 0.6 2.1 2 0 0 2 2 2 1 60Kd inner membrane protein RhoGAP PF00620.22 KOH00104.1 - 5.1e-40 136.5 0.2 5.4e-39 133.2 0.0 2.8 2 0 0 2 2 2 1 RhoGAP domain RasGEF PF00617.14 KOH00104.1 - 1.9e-20 73.3 2.0 8e-19 68.0 0.2 3.2 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 KOH00104.1 - 1.3e-18 67.0 2.1 6.2e-18 64.8 0.4 3.2 2 0 0 2 2 2 1 RasGEF N-terminal motif UPF0160 PF03690.8 KOH00105.1 - 3.7e-125 417.5 0.0 4.2e-125 417.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Sec34 PF04136.10 KOH00106.1 - 7.7e-29 100.4 4.7 7.7e-29 100.4 3.2 3.7 3 1 1 4 4 4 1 Sec34-like family UPF0184 PF03670.8 KOH00106.1 - 0.007 16.5 0.2 0.072 13.2 0.1 2.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0184) DUF3538 PF12057.3 KOH00106.1 - 0.026 14.1 0.1 0.09 12.3 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3538) PaO PF08417.7 KOH00106.1 - 0.051 13.5 0.1 1.7 8.6 0.0 2.7 2 0 0 2 2 2 0 Pheophorbide a oxygenase CBFD_NFYB_HMF PF00808.18 KOH00108.1 - 5.1e-11 42.4 0.1 7.8e-11 41.8 0.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 KOH00108.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 EVI2A PF05399.6 KOH00108.1 - 0.12 11.6 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) PCP_red PF08369.5 KOH00108.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit SPT2 PF08243.6 KOH00109.1 - 3.6e-29 101.4 30.7 3.6e-29 101.4 21.3 2.4 2 0 0 2 2 2 1 SPT2 chromatin protein Rad4 PF03835.10 KOH00110.1 - 2.9e-34 117.5 2.1 7.5e-34 116.2 1.4 1.8 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 KOH00110.1 - 2.5e-25 87.9 0.1 4.9e-25 87.0 0.1 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 KOH00110.1 - 1.1e-17 63.3 0.0 2.9e-17 61.9 0.0 1.8 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 KOH00110.1 - 7.3e-11 42.2 0.1 3.4e-10 40.1 0.1 2.3 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.14 KOH00110.1 - 9.4e-07 29.0 0.0 2.7e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF4523 PF15023.1 KOH00110.1 - 0.069 12.6 2.4 1.4 8.4 1.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) SNF2_N PF00176.18 KOH00111.1 - 5.4e-75 251.9 0.0 1.1e-74 251.0 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF4208 PF13907.1 KOH00111.1 - 2e-31 108.1 1.0 2e-31 108.1 0.7 3.4 4 0 0 4 4 4 1 Domain of unknown function (DUF4208) Chromo PF00385.19 KOH00111.1 - 5.2e-23 80.4 1.8 3.8e-14 52.1 0.1 3.3 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 KOH00111.1 - 3.2e-15 55.7 0.0 1.9e-14 53.2 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Myb_DNA-bind_6 PF13921.1 KOH00111.1 - 3.8e-05 23.7 0.0 0.00016 21.7 0.0 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 KOH00111.1 - 0.001 19.0 0.0 0.0036 17.3 0.0 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain RRM_1 PF00076.17 KOH00112.1 - 8.4e-86 281.6 5.5 1.4e-21 75.8 0.1 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOH00112.1 - 9.1e-58 192.1 0.2 3.3e-15 55.7 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOH00112.1 - 5.4e-42 141.4 0.1 3.1e-09 36.5 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 KOH00112.1 - 6.8e-24 83.3 1.0 6.9e-23 80.1 0.0 2.8 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_3 PF08777.6 KOH00112.1 - 5.2e-07 29.4 4.8 0.018 14.8 1.1 4.7 3 1 1 4 4 4 1 RNA binding motif YflT PF11181.3 KOH00112.1 - 0.00034 20.7 4.8 0.58 10.3 0.5 3.6 2 1 1 3 3 3 2 Heat induced stress protein YflT Nup35_RRM_2 PF14605.1 KOH00112.1 - 0.0028 17.3 0.3 16 5.3 0.0 3.7 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.6 KOH00112.1 - 0.0029 17.0 2.8 4.5 6.8 0.1 3.5 3 0 0 3 3 3 2 Ribonuclease B OB domain CbiG_mid PF11761.3 KOH00112.1 - 0.0034 17.5 0.3 0.59 10.4 0.0 2.9 2 1 0 2 2 2 1 Cobalamin biosynthesis central region TC1 PF15063.1 KOH00112.1 - 0.04 13.4 0.2 0.15 11.6 0.0 2.0 2 0 0 2 2 2 0 Thyroid cancer protein 1 Limkain-b1 PF11608.3 KOH00112.1 - 0.1 12.3 0.3 14 5.5 0.0 3.7 4 0 0 4 4 4 0 Limkain b1 CSD PF00313.17 KOH00112.1 - 0.17 11.7 1.9 13 5.6 0.0 3.5 3 0 0 3 3 3 0 'Cold-shock' DNA-binding domain E1-E2_ATPase PF00122.15 KOH00113.1 - 5.9e-15 54.9 0.9 1e-14 54.1 0.0 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 KOH00113.1 - 1.1e-13 50.9 0.0 3.3e-13 49.3 0.0 1.9 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 KOH00113.1 - 1.2e-12 48.4 0.0 3.1e-12 47.0 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOH00113.1 - 4.1e-10 40.4 0.2 3.4e-08 34.1 0.1 3.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KOH00113.1 - 0.0043 16.6 0.2 0.01 15.4 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PolyA_pol PF01743.15 KOH00115.1 - 2.6e-32 111.6 0.0 4.7e-32 110.8 0.0 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.2 KOH00115.1 - 1.7e-05 24.3 0.0 4.7e-05 22.8 0.0 1.8 1 1 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.1 KOH00115.1 - 0.0015 18.3 0.0 0.0042 16.9 0.0 1.7 2 0 0 2 2 2 1 tRNA nucleotidyltransferase domain 2 putative DUF3958 PF13125.1 KOH00115.1 - 0.064 13.1 1.2 0.98 9.3 0.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3958) JmjC PF02373.17 KOH00116.1 - 2.5e-41 140.4 0.7 2.5e-41 140.4 0.5 2.6 2 0 0 2 2 2 1 JmjC domain, hydroxylase JmjN PF02375.12 KOH00116.1 - 2.6e-15 55.6 2.0 6.9e-15 54.2 1.4 1.8 1 0 0 1 1 1 1 jmjN domain zf-H2C2_2 PF13465.1 KOH00116.1 - 3.8e-09 36.3 11.9 3.5e-07 30.1 4.7 3.0 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.21 KOH00116.1 - 2e-07 30.9 17.3 0.0009 19.4 2.6 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOH00116.1 - 1.8e-06 27.8 13.0 0.0012 19.0 1.1 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KOH00116.1 - 0.003 17.4 10.0 0.02 14.7 2.8 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.5 KOH00116.1 - 0.94 9.4 6.2 5.1 7.1 4.3 2.2 1 1 0 1 1 1 0 Zinc ribbon domain zf-met PF12874.2 KOH00116.1 - 1.5 9.1 8.8 11 6.3 1.3 3.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KOH00116.1 - 2.7 8.2 16.2 0.56 10.4 3.5 3.4 2 1 1 3 3 3 0 Zinc-finger double-stranded RNA-binding ADK PF00406.17 KOH00117.1 - 8.8e-42 142.5 0.0 1.1e-41 142.2 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 KOH00117.1 - 6e-13 48.2 0.0 1.3e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.1 KOH00117.1 - 1.1e-05 25.3 0.0 2.6e-05 24.1 0.0 1.6 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KOH00117.1 - 0.0042 17.3 1.0 0.023 15.0 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KOH00117.1 - 0.0095 16.7 0.0 0.015 16.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOH00117.1 - 0.083 11.9 0.0 0.25 10.4 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin ABC_tran PF00005.22 KOH00117.1 - 0.085 13.1 0.0 0.16 12.2 0.0 1.3 1 1 0 1 1 1 0 ABC transporter DUF1227 PF06777.6 KOH00118.1 - 2.8e-59 199.0 1.1 6.5e-59 197.8 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) DEAD_2 PF06733.10 KOH00118.1 - 2.6e-53 179.9 4.3 4.9e-53 179.0 3.0 1.5 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.1 KOH00118.1 - 1.6e-45 155.0 0.1 8.6e-45 152.6 0.0 2.2 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD PF00270.24 KOH00118.1 - 0.0027 17.2 0.1 0.92 8.9 0.0 2.7 3 0 0 3 3 3 2 DEAD/DEAH box helicase SNF2_N PF00176.18 KOH00118.1 - 0.016 13.9 0.2 0.65 8.7 0.0 2.3 2 0 0 2 2 2 0 SNF2 family N-terminal domain ResIII PF04851.10 KOH00118.1 - 0.052 13.3 0.7 0.96 9.2 0.5 2.3 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Sec63 PF02889.11 KOH00119.1 - 6.3e-171 567.6 9.8 7.6e-87 291.4 0.1 2.9 3 0 0 3 3 3 2 Sec63 Brl domain DEAD PF00270.24 KOH00119.1 - 2.1e-49 167.2 0.0 9.4e-32 109.8 0.0 3.8 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.10 KOH00119.1 - 5.5e-11 42.6 6.2 3.4e-09 36.7 0.0 4.2 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 KOH00119.1 - 2e-07 30.7 0.0 7.5e-07 28.9 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 KOH00119.1 - 3.8e-06 27.0 0.2 0.029 14.4 0.0 3.2 2 0 0 2 2 2 2 AAA domain PhoH PF02562.11 KOH00119.1 - 0.00018 20.8 0.0 0.17 11.1 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_19 PF13245.1 KOH00119.1 - 0.0068 16.1 0.0 2 8.2 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain Helicase_RecD PF05127.9 KOH00119.1 - 0.061 12.9 0.0 4.2 6.9 0.0 3.0 3 0 0 3 3 3 0 Helicase AAA_16 PF13191.1 KOH00119.1 - 0.11 12.4 0.0 2.8 7.8 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.13 KOH00119.1 - 0.23 10.9 0.0 0.76 9.2 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family Rad17 PF03215.10 KOH00120.1 - 3.3e-167 557.3 8.7 6e-165 549.8 6.1 2.1 1 1 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 KOH00120.1 - 0.0003 20.8 0.1 0.0017 18.3 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 KOH00120.1 - 0.00067 19.1 0.0 0.0021 17.5 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF258 PF03193.11 KOH00120.1 - 0.0031 16.7 0.0 0.0059 15.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 RNA_helicase PF00910.17 KOH00120.1 - 0.0037 17.4 0.0 0.012 15.7 0.0 1.9 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.16 KOH00120.1 - 0.01 15.0 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KOH00120.1 - 0.017 14.8 0.0 0.036 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.24 KOH00120.1 - 0.021 15.0 0.0 0.073 13.2 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOH00120.1 - 0.062 14.1 0.0 0.54 11.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.1 KOH00120.1 - 0.11 12.5 0.1 2 8.5 0.1 2.4 1 1 0 1 1 1 0 AAA domain Methyltransf_31 PF13847.1 KOH00121.1 - 2.2e-12 46.8 0.0 3.7e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOH00121.1 - 1.8e-09 37.9 0.0 2.9e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOH00121.1 - 8.6e-09 35.7 0.0 1.8e-08 34.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOH00121.1 - 3.5e-07 30.0 0.1 5.8e-07 29.3 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOH00121.1 - 1.6e-06 28.6 0.0 2.8e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOH00121.1 - 2.7e-06 27.6 0.0 5.1e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOH00121.1 - 0.00082 18.5 0.0 0.0012 17.9 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.15 KOH00121.1 - 0.001 18.2 0.0 0.0014 17.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.12 KOH00121.1 - 0.0033 16.4 0.0 0.0056 15.7 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 KOH00121.1 - 0.023 14.7 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_32 PF13679.1 KOH00121.1 - 0.053 13.2 0.0 0.085 12.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain AAA_12 PF13087.1 KOH00122.1 - 2.4e-60 203.3 0.1 2.4e-60 203.3 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 KOH00122.1 - 9.1e-42 143.2 0.5 9.1e-42 143.2 0.4 3.6 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOH00122.1 - 1.3e-10 40.8 0.0 8e-10 38.3 0.0 2.2 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 KOH00122.1 - 1.4e-09 37.8 0.0 2.3e-08 33.8 0.0 2.3 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 KOH00122.1 - 1.9e-05 24.3 7.4 0.065 12.7 0.0 4.8 5 0 0 5 5 5 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.1 KOH00122.1 - 0.0025 17.8 3.3 0.0041 17.2 0.0 3.0 3 0 0 3 3 3 1 UvrD-like helicase C-terminal domain PhoH PF02562.11 KOH00122.1 - 0.0052 16.0 0.0 0.017 14.3 0.0 1.8 1 0 0 1 1 1 1 PhoH-like protein AAA_16 PF13191.1 KOH00122.1 - 0.0052 16.7 0.0 0.024 14.6 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 KOH00122.1 - 0.0082 16.3 0.1 0.045 13.9 0.1 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOH00122.1 - 0.048 13.7 0.0 0.2 11.7 0.0 2.1 1 0 0 1 1 1 0 AAA domain 14-3-3 PF00244.15 KOH00123.1 - 5.7e-115 382.3 6.1 6.9e-115 382.0 4.2 1.1 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.6 KOH00123.1 - 0.041 13.7 0.4 0.14 11.9 0.3 1.9 1 0 0 1 1 1 0 Flagellar protein FlaF DUF885 PF05960.6 KOH00123.1 - 0.042 13.0 6.4 0.0086 15.2 1.3 1.9 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF885) E1_dh PF00676.15 KOH00124.1 - 1.2e-120 401.8 0.0 1.5e-120 401.5 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 KOH00124.1 - 0.0021 17.0 0.0 0.0037 16.2 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase KRTAP7 PF15034.1 KOH00124.1 - 0.011 16.3 3.5 0.066 13.8 0.1 2.9 2 2 0 2 2 2 0 KRTAP type 7 family Rad51 PF08423.6 KOH00125.1 - 1.3e-110 368.3 0.0 1.5e-110 368.1 0.0 1.0 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 KOH00125.1 - 1.4e-08 34.3 0.0 1.9e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOH00125.1 - 0.095 12.8 0.0 0.22 11.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain DUF2205 PF10224.4 KOH00127.1 - 5.1e-09 35.5 4.5 6.1e-09 35.3 3.1 1.1 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) DUF837 PF05769.6 KOH00127.1 - 0.0042 16.6 0.4 0.0047 16.4 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF837) DivIC PF04977.10 KOH00127.1 - 0.64 9.5 4.1 4.4 6.8 0.1 2.1 1 1 1 2 2 2 0 Septum formation initiator bZIP_1 PF00170.16 KOH00127.1 - 0.72 9.8 4.7 1.3 8.9 0.2 2.2 1 1 1 2 2 2 0 bZIP transcription factor Synaptonemal_3 PF15191.1 KOH00128.1 - 0.026 14.2 0.1 0.36 10.5 0.0 2.1 2 0 0 2 2 2 0 Synaptonemal complex central element protein 3 5-FTHF_cyc-lig PF01812.15 KOH00129.1 - 1.1e-52 178.5 0.0 1.3e-52 178.3 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Fe-ADH PF00465.14 KOH00130.1 - 2e-116 388.6 1.2 2.5e-116 388.3 0.8 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.1 KOH00130.1 - 2.5e-21 76.1 1.9 3.1e-14 52.8 0.1 2.2 1 1 1 2 2 2 2 Iron-containing alcohol dehydrogenase Mannosyl_trans3 PF11051.3 KOH00131.1 - 3.7e-60 203.5 0.2 5e-60 203.1 0.1 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Fungal_trans PF04082.13 KOH00132.1 - 2.4e-16 59.4 8.4 3.8e-16 58.7 5.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOH00132.1 - 8.8e-08 31.9 13.9 2e-07 30.7 9.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.19 KOH00133.1 - 1e-94 317.6 20.7 1.2e-94 317.4 14.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOH00133.1 - 1.6e-11 43.5 27.7 3.1e-08 32.7 5.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOH00133.1 - 2.7e-05 22.7 1.1 2.7e-05 22.7 0.8 3.5 3 1 1 4 4 4 3 MFS/sugar transport protein Alpha-amylase PF00128.19 KOH00134.1 - 2.3e-106 355.7 0.3 4.1e-106 354.9 0.2 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.1 KOH00134.1 - 0.043 12.7 0.0 0.094 11.6 0.0 1.5 2 0 0 2 2 2 0 glucanotransferase domain of human glycogen debranching enzyme Sugar_tr PF00083.19 KOH00135.1 - 9.4e-166 551.8 36.8 1.1e-165 551.6 25.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOH00135.1 - 1.8e-25 89.3 34.9 8.2e-23 80.6 14.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Alpha-amylase PF00128.19 KOH00136.1 - 4.3e-109 364.7 0.9 6.9e-109 364.0 0.6 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.1 KOH00136.1 - 0.0068 15.3 0.1 0.026 13.4 0.0 1.8 2 0 0 2 2 2 1 glucanotransferase domain of human glycogen debranching enzyme MFS_1 PF07690.11 KOH00137.1 - 1.4e-17 63.4 47.1 2.7e-16 59.2 29.2 3.5 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 KOH00137.1 - 1.3e-07 30.2 19.9 1.7e-07 29.8 13.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) SRP1_TIP1 PF00660.12 KOH00138.1 - 4.2e-32 110.0 0.1 5.2e-32 109.7 0.1 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family MFS_1 PF07690.11 KOH00139.1 - 2.1e-17 62.8 45.5 1.3e-15 57.0 31.2 3.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 KOH00139.1 - 1.5e-07 30.0 19.9 1.9e-07 29.6 13.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) SRP1_TIP1 PF00660.12 KOH00140.1 - 4.2e-32 110.0 0.1 5.2e-32 109.7 0.1 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family Sugar_tr PF00083.19 KOH00141.1 - 1.5e-86 290.8 21.2 1.7e-86 290.5 14.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOH00141.1 - 2.2e-32 112.1 24.7 2.2e-32 112.1 17.1 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 KOH00141.1 - 0.00086 17.6 10.4 0.0019 16.5 2.4 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) DUF4097 PF13349.1 KOH00141.1 - 0.019 14.5 2.1 1.8 8.0 0.4 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4097) LIM PF00412.17 KOH00143.1 - 8e-39 131.5 53.6 2.5e-15 56.2 5.2 4.4 4 0 0 4 4 4 4 LIM domain RhoGAP PF00620.22 KOH00143.1 - 9.1e-36 122.7 1.5 1.9e-35 121.7 0.1 2.3 3 0 0 3 3 3 1 RhoGAP domain SID PF11778.3 KOH00144.1 - 3.8e-46 156.4 2.1 3.8e-46 156.4 1.5 3.1 3 0 0 3 3 3 1 Septation initiation Cep57_CLD_2 PF14197.1 KOH00144.1 - 0.005 16.7 2.0 0.005 16.7 1.4 5.4 5 2 1 6 6 6 2 Centrosome localisation domain of PPC89 HTH_1 PF00126.22 KOH00144.1 - 0.0095 15.6 0.9 0.023 14.4 0.6 1.7 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Reo_sigmaC PF04582.7 KOH00144.1 - 0.15 11.2 3.6 5.3 6.1 0.1 2.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Amidohydro_1 PF01979.15 KOH00145.1 - 1.2e-55 189.4 0.0 1.4e-55 189.2 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 KOH00145.1 - 6.1e-11 42.1 0.0 3.1e-08 33.2 0.0 2.3 1 1 0 2 2 2 2 Amidohydrolase family Amidohydro_5 PF13594.1 KOH00145.1 - 6.1e-05 22.7 0.1 0.00022 20.9 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_4 PF13147.1 KOH00145.1 - 7.1e-05 22.9 0.0 0.0061 16.6 0.0 2.3 2 0 0 2 2 2 1 Amidohydrolase A_deaminase PF00962.17 KOH00145.1 - 0.018 13.9 0.0 0.58 9.0 0.0 2.2 1 1 1 2 2 2 0 Adenosine/AMP deaminase Hydrolase_6 PF13344.1 KOH00147.1 - 9.3e-28 96.0 0.0 3.1e-27 94.4 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOH00147.1 - 1.4e-15 58.2 0.0 2e-15 57.7 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOH00147.1 - 2.3e-12 46.4 0.0 4e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.1 KOH00147.1 - 1.3e-05 25.4 0.0 0.065 13.4 0.1 2.5 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hpt PF01627.18 KOH00148.1 - 9.9e-13 47.9 0.1 1.6e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Hpt domain PHB_acc PF05233.8 KOH00148.1 - 0.11 12.1 1.1 0.25 11.0 0.7 1.5 1 0 0 1 1 1 0 PHB accumulation regulatory domain RabGAP-TBC PF00566.13 KOH00149.1 - 3.1e-30 105.2 10.7 3.1e-30 105.2 7.4 4.0 3 2 2 5 5 5 2 Rab-GTPase-TBC domain LIM_bind PF01803.11 KOH00150.1 - 6.8e-51 172.6 2.1 9e-51 172.2 1.4 1.2 1 0 0 1 1 1 1 LIM-domain binding protein Ost4 PF10215.4 KOH00151.1 - 6.4e-18 63.9 1.6 6.8e-18 63.8 1.1 1.0 1 0 0 1 1 1 1 Oligosaccaryltransferase PsbT PF01405.12 KOH00151.1 - 0.094 12.3 2.3 0.2 11.2 1.6 1.6 1 1 0 1 1 1 0 Photosystem II reaction centre T protein FUSC_2 PF13515.1 KOH00152.1 - 1.8e-10 40.8 5.2 1.8e-10 40.8 3.6 2.4 2 0 0 2 2 2 1 Fusaric acid resistance protein-like DUF2422 PF10337.4 KOH00152.1 - 2.8e-05 23.0 3.5 2.8e-05 23.0 2.4 3.1 2 1 1 3 3 3 1 Protein of unknown function (DUF2422) DUF2421 PF10334.4 KOH00152.1 - 3.2e-05 23.6 0.0 7e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2421) ALMT PF11744.3 KOH00152.1 - 0.011 14.4 5.7 0.012 14.3 0.1 3.1 3 1 0 3 3 3 0 Aluminium activated malate transporter FUSC PF04632.7 KOH00152.1 - 0.049 12.0 0.0 0.049 12.0 0.0 2.6 2 1 1 3 3 3 0 Fusaric acid resistance protein family Y_phosphatase PF00102.22 KOH00153.1 - 3.3e-54 183.7 0.5 2.6e-53 180.7 0.3 2.1 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.15 KOH00153.1 - 4.4e-05 23.0 0.0 8.2e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 KOH00153.1 - 0.00057 20.1 0.0 0.0014 18.9 0.0 1.6 1 1 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.1 KOH00153.1 - 0.0011 19.0 0.2 0.004 17.1 0.0 1.9 2 0 0 2 2 2 1 Inositol hexakisphosphate Myotub-related PF06602.9 KOH00153.1 - 0.08 11.7 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain HSP70 PF00012.15 KOH00154.1 - 4.1e-226 751.5 9.4 4.6e-226 751.4 6.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOH00154.1 - 9.2e-17 60.6 0.2 1.5e-16 59.9 0.1 1.2 1 0 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.11 KOH00154.1 - 0.0045 16.6 0.0 0.0079 15.8 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hom_end_hint PF05203.11 KOH00155.1 - 2.8e-47 161.2 0.0 3.3e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 Hom_end-associated Hint Hom_end PF05204.9 KOH00155.1 - 1.1e-45 154.0 0.0 5.7e-39 132.4 0.0 2.5 2 0 0 2 2 2 2 Homing endonuclease LAGLIDADG_3 PF14528.1 KOH00155.1 - 7.7e-09 35.6 0.0 3.2e-06 27.2 0.0 2.9 3 1 0 3 3 3 2 LAGLIDADG-like domain DUF1794 PF08768.6 KOH00155.1 - 0.076 12.8 0.0 0.21 11.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1794) ArfGap PF01412.13 KOH00156.1 - 6.2e-31 106.6 0.4 1.6e-30 105.3 0.0 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Septin PF00735.13 KOH00157.1 - 4.6e-72 242.4 6.0 8.1e-67 225.1 0.6 2.7 3 0 0 3 3 3 2 Septin AAA_33 PF13671.1 KOH00157.1 - 0.0048 16.7 0.3 0.015 15.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain Guanylate_kin PF00625.16 KOH00157.1 - 0.0067 15.8 1.0 2.9 7.3 0.0 3.0 2 0 0 2 2 2 1 Guanylate kinase AAA_22 PF13401.1 KOH00157.1 - 0.007 16.5 0.0 0.021 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AIG1 PF04548.11 KOH00157.1 - 0.0088 15.1 1.9 0.012 14.7 0.0 2.1 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.18 KOH00157.1 - 0.013 15.3 0.0 0.013 15.3 0.0 3.4 3 1 0 3 3 2 0 Dynamin family DUF258 PF03193.11 KOH00157.1 - 0.025 13.7 0.0 0.083 12.0 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 KOH00157.1 - 0.036 14.8 0.1 0.19 12.5 0.0 2.3 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.1 KOH00157.1 - 0.058 13.3 0.6 0.58 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.17 KOH00157.1 - 0.063 13.4 0.0 0.19 11.8 0.0 1.9 1 0 0 1 1 1 0 RNA helicase FtsK_SpoIIIE PF01580.13 KOH00157.1 - 0.081 12.3 0.1 1.3 8.4 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_18 PF13238.1 KOH00157.1 - 0.12 12.6 3.7 0.45 10.8 0.0 2.9 2 1 0 2 2 2 0 AAA domain AAA PF00004.24 KOH00157.1 - 0.3 11.2 0.0 0.3 11.2 0.0 2.2 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Synaptobrevin PF00957.16 KOH00157.1 - 0.33 10.5 4.9 0.6 9.7 2.6 2.1 1 1 0 1 1 1 0 Synaptobrevin OmpH PF03938.9 KOH00157.1 - 8.2 6.3 14.5 0.68 9.8 5.3 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) V_ATPase_I PF01496.14 KOH00157.1 - 9.9 3.8 8.2 15 3.2 5.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RRM_1 PF00076.17 KOH00158.1 - 3e-17 61.9 0.0 1.3e-13 50.3 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOH00158.1 - 1.4e-08 34.5 0.0 7.1e-07 29.1 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF4153 PF13687.1 KOH00158.1 - 0.36 10.3 0.0 0.58 9.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4153) SUR7 PF06687.7 KOH00160.1 - 7.9e-41 139.9 5.5 9.9e-41 139.6 3.8 1.1 1 0 0 1 1 1 1 SUR7/PalI family Claudin_2 PF13903.1 KOH00160.1 - 4.8e-05 23.1 5.2 4.8e-05 23.1 3.6 1.8 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction ABC2_membrane_4 PF12730.2 KOH00160.1 - 0.051 12.7 15.3 0.1 11.7 4.6 2.9 3 0 0 3 3 3 0 ABC-2 family transporter protein Wzy_C PF04932.10 KOH00160.1 - 0.28 10.9 3.0 0.22 11.3 0.4 1.9 2 0 0 2 2 2 0 O-Antigen ligase Fig1 PF12351.3 KOH00160.1 - 1.1 9.1 16.7 0.036 13.9 7.5 1.5 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 POT1 PF02765.12 KOH00161.1 - 2.5e-18 66.3 1.1 3.9e-18 65.7 0.2 1.8 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 DUF4110 PF13422.1 KOH00161.1 - 0.024 14.4 0.8 0.99 9.2 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4110) Tyr_Deacylase PF02580.11 KOH00162.1 - 4.7e-48 162.8 0.1 5.2e-48 162.7 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase MARVEL PF01284.18 KOH00163.1 - 5.4e-26 91.1 11.4 8.1e-26 90.5 7.9 1.2 1 0 0 1 1 1 1 Membrane-associating domain FA_desaturase PF00487.19 KOH00163.1 - 0.012 15.0 1.6 0.012 15.0 1.1 1.6 1 1 1 2 2 2 0 Fatty acid desaturase Penaeidin PF05927.6 KOH00163.1 - 0.056 13.9 0.1 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 Penaeidin TMEM192 PF14802.1 KOH00163.1 - 0.3 9.9 3.6 0.3 9.9 0.7 2.2 1 1 1 2 2 2 0 TMEM192 family BCD PF15461.1 KOH00163.1 - 0.46 9.8 8.5 1.3 8.3 5.8 1.8 1 1 0 1 1 1 0 Beta-carotene 15,15'-dioxygenase Dexa_ind PF15198.1 KOH00163.1 - 0.56 10.1 2.6 1.4 8.8 1.8 1.6 1 0 0 1 1 1 0 Dexamethasone-induced PepSY_TM_3 PF13706.1 KOH00163.1 - 0.66 9.4 0.0 0.66 9.4 0.0 3.5 4 1 0 4 4 4 0 PepSY-associated TM helix Tic20 PF09685.5 KOH00163.1 - 1.2 9.1 8.8 1.4 8.9 4.2 2.0 2 0 0 2 2 2 0 Tic20-like protein Tetraspannin PF00335.15 KOH00163.1 - 4.3 6.5 16.1 0.36 10.0 6.6 2.1 1 1 1 2 2 2 0 Tetraspanin family Tim17 PF02466.14 KOH00164.1 - 5.3e-46 155.8 7.8 7.9e-46 155.2 5.4 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DLH PF01738.13 KOH00164.1 - 0.11 11.7 0.6 0.54 9.4 0.0 2.0 2 1 0 2 2 2 0 Dienelactone hydrolase family JAB PF01398.16 KOH00165.1 - 6.1e-28 96.8 0.7 2.3e-27 95.0 0.0 2.2 2 1 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 KOH00165.1 - 7.1e-05 22.3 0.0 0.00017 21.1 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain ELFV_dehydrog PF00208.16 KOH00166.1 - 9.5e-61 205.4 0.0 4e-60 203.4 0.0 1.9 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.7 KOH00166.1 - 5e-17 60.7 5.9 2.4e-12 45.2 0.2 2.8 2 1 1 3 3 3 2 Bacterial NAD-glutamate dehydrogenase DUF2564 PF10819.3 KOH00166.1 - 0.0099 15.9 0.0 0.029 14.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2564) ELFV_dehydrog_N PF02812.13 KOH00166.1 - 0.052 13.1 0.0 0.17 11.5 0.0 1.8 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Pkinase PF00069.20 KOH00167.1 - 2.5e-55 187.4 0.0 3.9e-55 186.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00167.1 - 2.9e-21 75.7 0.0 6e-21 74.6 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH00167.1 - 0.00011 21.2 0.1 0.0004 19.4 0.1 1.8 1 1 0 1 1 1 1 Kinase-like RRM_1 PF00076.17 KOH00168.1 - 0.00061 19.3 0.0 0.0014 18.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOH00168.1 - 0.00098 19.0 0.0 0.0018 18.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SHR3_chaperone PF08229.6 KOH00169.1 - 1.2e-80 269.0 0.5 1.5e-80 268.8 0.3 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 Tetraspannin PF00335.15 KOH00169.1 - 0.0033 16.7 1.8 0.041 13.1 1.3 2.0 1 1 0 1 1 1 1 Tetraspanin family DUF2681 PF10883.3 KOH00169.1 - 0.015 15.4 2.5 0.039 14.1 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DUF1049 PF06305.6 KOH00169.1 - 0.026 14.0 1.4 1.4 8.4 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1049) Romo1 PF10247.4 KOH00170.1 - 0.035 14.2 0.1 0.075 13.2 0.1 1.5 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 Alpha-E PF04168.7 KOH00170.1 - 0.038 13.3 0.0 0.061 12.6 0.0 1.3 1 0 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. Syndecan PF01034.15 KOH00170.1 - 0.061 12.9 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Syndecan domain Podoplanin PF05808.6 KOH00170.1 - 3.6 7.1 13.2 8.9 5.8 8.3 2.3 1 1 1 2 2 2 0 Podoplanin AA_permease_2 PF13520.1 KOH00171.1 - 3.2e-67 226.9 42.4 4e-67 226.6 29.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOH00171.1 - 5.9e-22 77.6 34.5 9.4e-22 76.9 23.9 1.2 1 0 0 1 1 1 1 Amino acid permease DUF3487 PF11990.3 KOH00171.1 - 0.34 10.3 0.1 0.34 10.3 0.0 4.7 5 1 1 6 6 6 0 Protein of unknown function (DUF3487) DUF1129 PF06570.6 KOH00171.1 - 3.4 6.9 5.6 0.6 9.3 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) RRM_1 PF00076.17 KOH00172.1 - 1.1e-06 28.1 0.1 2.7e-06 26.8 0.1 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOH00172.1 - 7.6e-06 25.6 0.0 1.7e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOH00172.1 - 0.0027 17.6 0.0 0.0059 16.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KOH00172.1 - 0.021 14.5 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 KOH00172.1 - 0.028 14.2 0.1 0.058 13.2 0.0 1.5 1 0 0 1 1 1 0 RNA binding motif PAP_RNA-bind PF04926.10 KOH00172.1 - 0.076 12.5 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain zf-CCCH PF00642.19 KOH00172.1 - 1.4 8.7 5.2 2.4 7.9 3.6 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ribosomal_L7Ae PF01248.21 KOH00173.1 - 9.2e-28 95.6 0.8 1.5e-27 94.9 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 KOH00173.1 - 0.00012 21.8 0.1 0.00033 20.5 0.0 1.6 2 0 0 2 2 2 1 RNase P subunit Pop3 RVT_connect PF06815.8 KOH00173.1 - 0.13 12.1 0.4 0.22 11.4 0.0 1.6 2 0 0 2 2 2 0 Reverse transcriptase connection domain GLE1 PF07817.8 KOH00174.1 - 2e-90 302.2 0.1 2e-90 302.2 0.0 2.6 2 1 0 3 3 3 1 GLE1-like protein CAF-1_p150 PF11600.3 KOH00174.1 - 0.002 17.5 46.4 0.002 17.5 32.1 1.7 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Macoilin PF09726.4 KOH00174.1 - 0.019 13.3 27.8 0.027 12.8 19.2 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF4613 PF15390.1 KOH00174.1 - 0.019 13.1 15.7 0.029 12.5 10.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) SprA-related PF12118.3 KOH00174.1 - 0.022 14.0 21.0 0.031 13.6 14.6 1.2 1 0 0 1 1 1 0 SprA-related family Hom_end_hint PF05203.11 KOH00174.1 - 0.04 13.6 3.4 0.052 13.2 2.3 1.4 1 0 0 1 1 1 0 Hom_end-associated Hint Pilt PF15453.1 KOH00174.1 - 0.29 10.7 17.0 0.5 10.0 11.8 1.3 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions DUF1777 PF08648.7 KOH00174.1 - 2.2 8.0 26.3 1.5 8.5 16.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) Asp-B-Hydro_N PF05279.6 KOH00174.1 - 2.5 7.8 24.9 4.1 7.1 17.2 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF2252 PF10009.4 KOH00174.1 - 4.1 6.1 15.3 6.9 5.4 10.6 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) RR_TM4-6 PF06459.7 KOH00174.1 - 6.9 6.4 22.3 13 5.5 15.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LMBR1 PF04791.11 KOH00174.1 - 8 4.9 8.8 11 4.4 6.1 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Na_Ca_ex PF01699.19 KOH00175.1 - 1.9e-58 196.0 26.1 1.2e-30 106.0 3.8 3.2 2 1 1 3 3 3 2 Sodium/calcium exchanger protein WBP-1 PF11669.3 KOH00175.1 - 0.067 13.2 3.4 0.11 12.6 0.1 2.8 2 1 1 3 3 3 0 WW domain-binding protein 1 Mucin PF01456.12 KOH00175.1 - 0.078 12.7 0.1 0.21 11.3 0.0 1.6 2 0 0 2 2 2 0 Mucin-like glycoprotein Porphobil_deam PF01379.15 KOH00176.1 - 6.4e-89 296.5 0.0 8.4e-89 296.1 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 KOH00176.1 - 9.3e-21 73.7 1.6 1.5e-20 73.0 1.1 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Reticulon PF02453.12 KOH00177.1 - 8e-33 113.4 0.2 1.3e-32 112.7 0.1 1.3 1 0 0 1 1 1 1 Reticulon SCFA_trans PF02667.9 KOH00177.1 - 0.037 12.8 0.3 0.057 12.1 0.2 1.2 1 0 0 1 1 1 0 Short chain fatty acid transporter Sel1 PF08238.7 KOH00178.1 - 1.1e-33 114.8 18.6 1.6e-06 28.5 0.0 7.7 7 1 0 7 7 7 7 Sel1 repeat TPR_8 PF13181.1 KOH00178.1 - 0.23 11.3 6.4 1.5 8.7 1.1 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOH00178.1 - 0.69 9.6 13.8 5.1 6.8 0.2 5.2 3 2 3 6 6 6 0 TPR repeat Ribosomal_L10 PF00466.15 KOH00179.1 - 2.1e-10 40.4 0.0 3.4e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 A2M_recep PF07677.9 KOH00179.1 - 0.036 14.2 0.3 0.083 13.0 0.2 1.5 1 0 0 1 1 1 0 A-macroglobulin receptor Methyltransf_4 PF02390.12 KOH00180.1 - 5.4e-63 211.6 0.1 7.9e-63 211.0 0.1 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 KOH00180.1 - 5.8e-05 23.6 0.0 0.00013 22.5 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOH00180.1 - 0.00012 21.7 0.0 0.00025 20.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOH00180.1 - 0.00047 20.1 0.0 0.00075 19.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOH00180.1 - 0.001 18.4 0.0 0.0022 17.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 KOH00180.1 - 0.006 16.9 0.0 0.014 15.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOH00180.1 - 0.011 16.2 0.0 0.031 14.7 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.13 KOH00180.1 - 0.02 13.9 0.0 0.061 12.4 0.0 1.7 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family FmrO PF07091.6 KOH00180.1 - 0.099 11.6 0.0 0.22 10.4 0.0 1.5 2 0 0 2 2 2 0 Ribosomal RNA methyltransferase (FmrO) DUF3958 PF13125.1 KOH00180.1 - 0.72 9.7 3.7 0.3 11.0 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) DNA_binding_1 PF01035.15 KOH00181.1 - 1.7e-29 101.3 0.0 2.5e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N PF02870.10 KOH00181.1 - 4.1e-10 40.1 0.1 6.5e-10 39.4 0.1 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain Sugar_tr PF00083.19 KOH00182.1 - 5.6e-38 130.6 22.8 7.2e-38 130.3 15.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOH00182.1 - 5.4e-12 45.1 20.7 5.4e-12 45.1 14.4 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Mito_carr PF00153.22 KOH00183.1 - 1.4e-31 108.0 0.1 1.1e-14 53.8 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Apc1 PF12859.2 KOH00184.1 - 0.2 11.8 1.8 14 5.9 0.0 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 Sec31 PF11549.3 KOH00185.1 - 2e-26 91.3 2.7 2e-26 91.3 1.9 2.9 2 0 0 2 2 2 1 Protein transport protein SEC31 WD40 PF00400.27 KOH00185.1 - 7.7e-22 76.3 12.3 1.5e-06 27.8 0.0 8.2 8 0 0 8 8 8 4 WD domain, G-beta repeat SRA1 PF07304.6 KOH00185.1 - 5.5e-09 35.9 0.0 5.5e-09 35.9 0.0 2.6 2 0 0 2 2 2 1 Steroid receptor RNA activator (SRA1) eIF2A PF08662.6 KOH00185.1 - 5.7e-05 22.9 1.7 0.00078 19.2 0.1 2.6 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Sec16_C PF12931.2 KOH00185.1 - 0.00026 20.8 0.5 0.00052 19.8 0.4 1.5 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Prp18 PF02840.10 KOH00185.1 - 0.8 9.5 6.2 0.18 11.6 0.3 2.9 3 1 0 3 3 3 0 Prp18 domain Sugar_tr PF00083.19 KOH00186.1 - 1.1e-130 436.2 31.3 1.3e-130 436.0 21.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOH00186.1 - 1.8e-18 66.4 40.7 1.5e-14 53.4 11.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Na_trans_assoc PF06512.8 KOH00186.1 - 1.2 9.0 3.9 2.7 7.8 2.7 1.6 1 0 0 1 1 1 0 Sodium ion transport-associated Prenyltransf PF01255.14 KOH00187.1 - 0.0024 17.0 0.0 0.0053 15.9 0.0 1.6 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Thia_YuaJ PF09515.5 KOH00187.1 - 0.55 9.9 2.9 0.81 9.4 1.2 1.7 1 1 1 2 2 2 0 Thiamine transporter protein (Thia_YuaJ) Arf PF00025.16 KOH00188.1 - 5e-78 260.3 0.0 5.8e-78 260.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KOH00188.1 - 3.7e-14 52.4 0.0 4e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 KOH00188.1 - 2.9e-13 49.4 0.0 3.5e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 KOH00188.1 - 2.7e-11 42.8 0.3 3.3e-08 32.6 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 KOH00188.1 - 6.8e-11 41.7 0.0 8.2e-11 41.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 KOH00188.1 - 2.9e-10 40.6 0.0 3.9e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 KOH00188.1 - 7.9e-06 25.8 0.0 1.2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOH00188.1 - 0.0055 16.1 0.0 0.03 13.7 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRP54 PF00448.17 KOH00188.1 - 0.006 16.0 0.2 0.011 15.1 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_33 PF13671.1 KOH00188.1 - 0.0087 15.9 0.1 0.014 15.3 0.1 1.5 1 1 0 1 1 1 1 AAA domain NACHT PF05729.7 KOH00188.1 - 0.012 15.3 0.3 1.5 8.4 0.0 2.1 2 0 0 2 2 2 0 NACHT domain cobW PF02492.14 KOH00188.1 - 0.027 13.9 0.1 6.3 6.2 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.22 KOH00188.1 - 0.036 14.3 0.1 0.065 13.5 0.0 1.5 1 1 0 1 1 1 0 ABC transporter 6PF2K PF01591.13 KOH00188.1 - 0.046 12.8 0.1 0.061 12.3 0.1 1.4 1 1 0 1 1 1 0 6-phosphofructo-2-kinase DBD_Tnp_Mut PF03108.10 KOH00188.1 - 0.1 12.2 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 MuDR family transposase Thymidylate_kin PF02223.12 KOH00188.1 - 0.26 10.6 0.9 0.91 8.8 0.2 1.9 2 0 0 2 2 2 0 Thymidylate kinase Ribosomal_L29 PF00831.18 KOH00189.1 - 9.6e-16 57.2 2.0 9.6e-16 57.2 1.4 2.3 2 0 0 2 2 2 1 Ribosomal L29 protein MRP-L47 PF06984.8 KOH00189.1 - 0.33 10.8 3.2 0.31 10.9 0.3 2.3 2 2 0 2 2 2 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DUF4600 PF15372.1 KOH00189.1 - 0.72 10.0 8.1 0.21 11.7 2.9 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) Malate_DH PF12434.3 KOH00189.1 - 7.8 6.2 10.8 5.9 6.6 0.4 3.3 3 0 0 3 3 3 0 Malate dehydrogenase enzyme Ufd2P_core PF10408.4 KOH00190.1 - 3.1e-187 623.6 5.1 3.1e-187 623.6 3.5 1.4 2 0 0 2 2 2 1 Ubiquitin elongating factor core U-box PF04564.10 KOH00190.1 - 3.9e-27 94.0 2.0 1.2e-26 92.4 1.4 1.9 1 0 0 1 1 1 1 U-box domain R3H PF01424.17 KOH00191.1 - 8.4e-09 34.9 0.1 1.7e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 R3H domain IpaC_SipC PF09599.5 KOH00191.1 - 0.098 11.6 6.8 0.18 10.8 4.7 1.4 1 0 0 1 1 1 0 Salmonella-Shigella invasin protein C (IpaC_SipC) Metallophos PF00149.23 KOH00192.1 - 8e-29 100.4 0.3 1.5e-28 99.5 0.1 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase WTX PF09422.5 KOH00192.1 - 0.028 13.4 0.5 0.036 13.0 0.3 1.1 1 0 0 1 1 1 0 WTX protein TSA PF03249.8 KOH00193.1 - 0.085 11.3 1.4 0.13 10.7 1.0 1.2 1 0 0 1 1 1 0 Type specific antigen ATP-synt_ab PF00006.20 KOH00194.1 - 9.1e-123 407.7 0.1 1.7e-122 406.8 0.0 1.5 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 KOH00194.1 - 3.4e-19 69.3 0.1 7.4e-19 68.2 0.1 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 KOH00194.1 - 6.3e-17 61.5 1.6 1.5e-16 60.2 1.1 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_14 PF13173.1 KOH00194.1 - 0.0063 16.4 0.0 0.02 14.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain Mit_KHE1 PF10173.4 KOH00195.1 - 3.5e-57 193.2 3.9 4.7e-57 192.8 2.7 1.2 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related Herpes_U34 PF04541.8 KOH00195.1 - 0.069 12.0 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus virion protein U34 HMGL-like PF00682.14 KOH00196.1 - 7.9e-75 251.5 0.2 1.4e-74 250.7 0.1 1.4 1 0 0 1 1 1 1 HMGL-like ADP_PFK_GK PF04587.10 KOH00196.1 - 0.018 13.2 0.0 0.027 12.6 0.0 1.2 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region Trp_syntA PF00290.15 KOH00196.1 - 0.045 12.2 0.0 6.9 5.1 0.0 2.5 2 0 0 2 2 2 0 Tryptophan synthase alpha chain DUF1507 PF07408.6 KOH00196.1 - 0.065 12.9 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1507) IATP PF04568.7 KOH00197.1 - 1.3e-21 76.4 0.6 1.4e-21 76.3 0.4 1.0 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Fib_alpha PF08702.5 KOH00197.1 - 0.0027 17.8 0.5 0.003 17.6 0.4 1.1 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Atg14 PF10186.4 KOH00197.1 - 0.038 12.9 0.8 0.033 13.1 0.5 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DivIC PF04977.10 KOH00197.1 - 0.042 13.3 3.3 0.057 12.9 2.3 1.3 1 0 0 1 1 1 0 Septum formation initiator ABC_tran_2 PF12848.2 KOH00197.1 - 0.092 12.6 3.5 0.13 12.1 2.4 1.3 1 0 0 1 1 1 0 ABC transporter XhlA PF10779.4 KOH00197.1 - 0.11 12.4 1.6 0.12 12.2 1.1 1.2 1 0 0 1 1 1 0 Haemolysin XhlA DUF4140 PF13600.1 KOH00197.1 - 0.11 12.8 0.5 0.16 12.3 0.4 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) PspB PF06667.7 KOH00197.1 - 0.14 12.0 1.9 0.2 11.6 1.3 1.1 1 0 0 1 1 1 0 Phage shock protein B DUF3813 PF12758.2 KOH00197.1 - 0.2 11.8 3.8 0.37 10.9 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3813) Pox_A_type_inc PF04508.7 KOH00197.1 - 3.7 7.5 8.4 2 8.3 1.0 2.5 1 1 1 2 2 2 0 Viral A-type inclusion protein repeat TMEM154 PF15102.1 KOH00198.1 - 0.13 11.9 0.0 5.2 6.7 0.0 2.6 2 0 0 2 2 2 0 TMEM154 protein family Cyclin_N PF00134.18 KOH00199.1 - 2.3e-15 56.2 0.0 3.6e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 KOH00199.1 - 2.9e-07 31.0 0.0 4.8e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Cyclin FAD-oxidase_C PF02913.14 KOH00200.1 - 1.6e-61 207.7 0.0 2.1e-61 207.4 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 KOH00200.1 - 1.2e-33 115.5 0.2 2.4e-33 114.5 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain UPF0029 PF01205.14 KOH00201.1 - 3e-35 120.2 2.3 1.1e-33 115.1 1.6 2.0 1 1 0 1 1 1 1 Uncharacterized protein family UPF0029 SR-25 PF10500.4 KOH00201.1 - 0.028 13.8 3.2 0.037 13.5 2.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Y_phosphatase PF00102.22 KOH00201.1 - 0.054 12.8 1.9 0.065 12.5 1.3 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase TraH_2 PF06871.6 KOH00201.1 - 0.41 10.0 1.7 17 4.7 0.0 2.1 1 1 1 2 2 2 0 TraH_2 zf-CCHC PF00098.18 KOH00203.1 - 3.7e-10 39.2 40.6 7.2e-05 22.5 2.2 5.4 5 1 0 5 5 5 4 Zinc knuckle zf-CCHC_2 PF13696.1 KOH00203.1 - 1.4 8.4 29.7 0.34 10.4 0.8 5.2 2 1 3 5 5 5 0 Zinc knuckle FAD-oxidase_C PF02913.14 KOH00204.1 - 1.4e-56 191.6 0.3 2.1e-56 191.0 0.2 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 KOH00204.1 - 2.6e-36 124.1 0.0 7.7e-36 122.6 0.0 1.9 1 0 0 1 1 1 1 FAD binding domain DUF3602 PF12223.3 KOH00205.1 - 6.6e-18 64.8 20.0 4.1e-05 23.8 0.1 4.5 3 1 1 4 4 4 4 Protein of unknown function (DUF3602) PBP1_TM PF14812.1 KOH00205.1 - 0.03 14.6 3.0 0.03 14.6 2.1 2.4 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3245 PF11595.3 KOH00205.1 - 0.75 10.0 11.3 2 8.7 7.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Glyco_tran_28_C PF04101.11 KOH00205.1 - 1.2 8.7 6.8 12 5.4 0.0 3.9 4 1 1 5 5 5 0 Glycosyltransferase family 28 C-terminal domain DUF912 PF06024.7 KOH00205.1 - 1.4 9.0 3.5 1.8 8.6 1.2 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Glu_synthase PF01645.12 KOH00206.1 - 4.5e-158 525.9 0.1 1.4e-157 524.3 0.0 1.8 2 0 0 2 2 2 1 Conserved region in glutamate synthase GATase_2 PF00310.16 KOH00206.1 - 7.2e-138 459.2 0.0 1e-137 458.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.9 KOH00206.1 - 7.9e-119 396.1 0.0 2.4e-118 394.5 0.0 1.8 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.14 KOH00206.1 - 3.6e-61 205.7 2.0 6.3e-61 204.9 1.4 1.3 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.1 KOH00206.1 - 8e-24 83.3 0.0 1.5e-23 82.5 0.0 1.4 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.9 KOH00206.1 - 2.7e-12 46.9 0.0 1.1e-11 44.9 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KOH00206.1 - 2.5e-08 33.8 0.0 6.9e-08 32.4 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 KOH00206.1 - 4.3e-08 33.4 1.8 2.4e-06 27.8 0.0 3.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOH00206.1 - 2e-07 31.2 0.1 0.0017 18.4 0.0 2.7 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 KOH00206.1 - 8.1e-06 25.1 0.0 1.5e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase HI0933_like PF03486.9 KOH00206.1 - 0.00024 19.6 0.1 0.00054 18.5 0.1 1.6 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.12 KOH00206.1 - 0.00025 20.2 1.5 0.00094 18.3 0.0 2.6 4 0 0 4 4 4 1 Thi4 family DAO PF01266.19 KOH00206.1 - 0.00031 19.7 0.2 0.00083 18.3 0.1 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 KOH00206.1 - 0.0015 17.6 0.0 0.0028 16.8 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.14 KOH00206.1 - 0.002 17.3 0.0 0.034 13.2 0.0 2.7 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.19 KOH00206.1 - 0.0023 16.8 0.2 0.0042 15.9 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.14 KOH00206.1 - 0.0023 17.0 0.1 0.0047 16.0 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_Gly3P_dh_N PF01210.18 KOH00206.1 - 0.012 15.3 0.0 0.042 13.5 0.0 2.0 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GATase_6 PF13522.1 KOH00206.1 - 0.016 15.1 0.0 0.05 13.5 0.0 1.9 1 1 0 1 1 1 0 Glutamine amidotransferase domain 3HCDH_N PF02737.13 KOH00206.1 - 0.024 14.2 0.0 0.075 12.6 0.0 1.9 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.17 KOH00206.1 - 0.026 13.3 0.4 0.094 11.5 0.0 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_7 PF13241.1 KOH00206.1 - 0.055 13.7 1.1 7.1 6.9 0.0 2.9 2 0 0 2 2 2 0 Putative NAD(P)-binding Rossmann-like PF10727.4 KOH00206.1 - 0.058 13.1 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Rossmann-like domain FMN_dh PF01070.13 KOH00206.1 - 0.14 10.9 1.6 0.57 8.9 0.6 2.2 3 0 0 3 3 3 0 FMN-dependent dehydrogenase AdoHcyase_NAD PF00670.16 KOH00206.1 - 0.45 10.3 4.2 11 5.8 0.1 2.8 1 1 1 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Fungal_trans_2 PF11951.3 KOH00207.1 - 7e-62 209.2 3.0 8.4e-62 208.9 2.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOH00207.1 - 6.8e-08 32.3 9.0 1.2e-07 31.5 6.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF848 PF05852.6 KOH00208.1 - 0.021 14.6 0.2 0.034 14.0 0.2 1.3 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) LEA_3 PF03242.8 KOH00208.1 - 0.034 14.3 3.2 0.088 13.0 0.0 2.7 1 1 1 2 2 2 0 Late embryogenesis abundant protein RAP1 PF07218.6 KOH00208.1 - 0.063 11.3 1.6 0.075 11.1 1.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Attachment_P66 PF11263.3 KOH00208.1 - 0.097 11.6 0.0 0.2 10.6 0.0 1.5 1 0 0 1 1 1 0 Borrelia burgdorferi attachment protein P66 ADH_N PF08240.7 KOH00209.1 - 7e-28 96.5 2.4 1.5e-27 95.4 1.7 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOH00209.1 - 1e-21 76.8 0.2 1.7e-21 76.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KOH00209.1 - 0.0016 19.3 0.0 0.0043 17.9 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 KOH00209.1 - 0.0037 16.4 0.1 0.0063 15.6 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 KOH00209.1 - 0.034 13.5 0.5 0.058 12.7 0.3 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.13 KOH00209.1 - 0.056 13.4 0.1 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain zf-RanBP PF00641.13 KOH00210.1 - 2.7e-23 80.7 14.8 4.3e-12 44.9 1.6 3.3 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.17 KOH00210.1 - 1.5e-08 34.0 0.0 0.00078 19.0 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOH00210.1 - 0.00053 19.9 0.0 0.0076 16.2 0.0 2.6 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DZR PF12773.2 KOH00210.1 - 0.05 13.4 9.1 0.91 9.3 1.2 2.4 2 0 0 2 2 2 0 Double zinc ribbon AAA_18 PF13238.1 KOH00211.1 - 2.5e-26 92.4 0.1 3.7e-26 91.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOH00211.1 - 1e-13 52.1 0.4 1.8e-13 51.3 0.2 1.5 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.1 KOH00211.1 - 0.00018 21.4 0.5 0.00095 19.1 0.3 1.9 1 1 0 1 1 1 1 Cytidylate kinase-like family RNA_helicase PF00910.17 KOH00211.1 - 0.00021 21.4 0.3 0.00055 20.0 0.0 1.7 2 0 0 2 2 2 1 RNA helicase KTI12 PF08433.5 KOH00211.1 - 0.0013 17.9 0.0 0.0063 15.7 0.0 2.0 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_28 PF13521.1 KOH00211.1 - 0.0013 18.6 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOH00211.1 - 0.0018 18.2 0.0 0.0031 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Thymidylate_kin PF02223.12 KOH00211.1 - 0.0024 17.2 0.1 1.1 8.5 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase AAA_33 PF13671.1 KOH00211.1 - 0.0034 17.2 0.1 0.56 10.0 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KOH00211.1 - 0.0043 16.9 0.0 0.0072 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 KOH00211.1 - 0.0087 16.2 0.0 0.013 15.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOH00211.1 - 0.0094 16.0 0.1 0.019 15.1 0.1 1.5 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOH00211.1 - 0.01 14.9 0.0 0.017 14.2 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin ADK PF00406.17 KOH00211.1 - 0.044 13.6 0.1 2.2 8.1 0.0 2.2 2 0 0 2 2 2 0 Adenylate kinase AAA_5 PF07728.9 KOH00211.1 - 0.047 13.4 0.0 0.074 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.13 KOH00211.1 - 0.071 12.6 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.10 KOH00211.1 - 0.082 12.6 0.1 0.19 11.4 0.0 1.6 2 0 0 2 2 2 0 NTPase Baculo_helicase PF04735.7 KOH00211.1 - 0.1 9.9 0.0 0.15 9.3 0.0 1.2 1 0 0 1 1 1 0 Baculovirus DNA helicase MobB PF03205.9 KOH00211.1 - 0.1 12.2 0.1 0.19 11.4 0.0 1.5 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NOT2_3_5 PF04153.13 KOH00212.1 - 2.6e-34 117.9 1.5 3.2e-34 117.6 1.0 1.1 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Imm43 PF15602.1 KOH00212.1 - 0.064 13.2 0.1 0.58 10.1 0.0 2.0 2 0 0 2 2 2 0 Immunity protein 43 DNA_ligase_A_M PF01068.16 KOH00213.1 - 3.3e-62 209.4 0.3 4.7e-62 208.9 0.2 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 KOH00213.1 - 2.5e-56 190.2 0.2 4.3e-56 189.5 0.2 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 KOH00213.1 - 4e-26 91.2 0.0 1.6e-25 89.2 0.0 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.1 KOH00213.1 - 0.0055 16.3 0.8 1.5 8.5 0.0 2.6 2 0 0 2 2 2 2 DNA ligase OB-like domain Phasin PF05597.6 KOH00213.1 - 0.066 12.9 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Macoilin PF09726.4 KOH00213.1 - 3.4 5.8 5.7 4.9 5.3 3.9 1.1 1 0 0 1 1 1 0 Transmembrane protein ENTH PF01417.15 KOH00214.1 - 1.1e-41 141.6 0.4 1.1e-41 141.6 0.3 1.8 2 0 0 2 2 2 1 ENTH domain DUF3668 PF12416.3 KOH00214.1 - 0.0078 15.4 11.2 0.044 12.9 0.0 3.2 1 1 2 3 3 3 2 Cep120 protein Cytochrom_B559a PF00284.15 KOH00214.1 - 0.14 11.6 5.2 2.4 7.7 0.1 3.8 3 0 0 3 3 3 0 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit CENP-X PF09415.5 KOH00215.1 - 3.4e-20 71.6 0.0 4.2e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 CENP-S associating Centromere protein X DEAD PF00270.24 KOH00216.1 - 2.7e-41 140.8 0.1 4.4e-41 140.1 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOH00216.1 - 1e-25 89.3 0.1 2.5e-25 88.1 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 KOH00216.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain Pkinase PF00069.20 KOH00217.1 - 5.1e-67 225.7 0.1 7.9e-67 225.1 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00217.1 - 4e-38 130.9 0.0 5.4e-38 130.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH00217.1 - 6.2e-05 22.0 0.0 0.00012 21.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like WD40 PF00400.27 KOH00219.1 - 1e-09 37.8 5.7 0.0016 18.2 0.0 5.1 6 0 0 6 6 6 2 WD domain, G-beta repeat DUF290 PF01060.18 KOH00219.1 - 0.0043 17.0 0.1 0.029 14.3 0.0 2.3 2 1 0 2 2 2 1 Transthyretin-like family Cyclin_N PF00134.18 KOH00220.1 - 6.4e-44 148.5 0.1 1.4e-43 147.5 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 KOH00220.1 - 8.4e-28 96.6 0.1 1.7e-27 95.7 0.1 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain SIN1 PF05422.7 KOH00220.1 - 0.043 12.3 0.6 0.06 11.8 0.4 1.1 1 0 0 1 1 1 0 Stress-activated map kinase interacting protein 1 (SIN1) MutS_V PF00488.16 KOH00221.1 - 4.3e-55 186.6 0.0 7.3e-55 185.9 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 KOH00221.1 - 1.8e-26 93.2 0.3 4.6e-26 91.8 0.2 1.7 2 0 0 2 2 2 1 MutS domain III AAA_29 PF13555.1 KOH00221.1 - 0.04 13.4 0.5 0.16 11.4 0.1 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain Zot PF05707.7 KOH00221.1 - 0.045 13.2 0.3 7.3 5.9 0.0 2.5 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) AAA_14 PF13173.1 KOH00221.1 - 0.49 10.3 6.2 0.29 11.0 0.1 3.5 3 1 1 4 4 4 0 AAA domain Sas10 PF09368.5 KOH00222.1 - 1.8e-29 101.6 10.3 1.8e-29 101.6 7.2 2.3 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.10 KOH00222.1 - 8.1e-11 41.9 0.1 3e-10 40.1 0.1 2.1 1 0 0 1 1 1 1 Sas10/Utp3/C1D family RNA_pol_Rpc4 PF05132.9 KOH00223.1 - 3.7e-31 107.8 0.5 3.7e-31 107.8 0.3 2.9 3 0 0 3 3 3 1 RNA polymerase III RPC4 IncA PF04156.9 KOH00223.1 - 0.06 12.9 7.6 0.11 12.0 5.3 1.5 1 0 0 1 1 1 0 IncA protein APG9 PF04109.11 KOH00224.1 - 9.6e-163 541.3 7.9 1.3e-162 540.8 5.5 1.2 1 0 0 1 1 1 1 Autophagy protein Apg9 Nop14 PF04147.7 KOH00225.1 - 4.7e-233 775.7 75.7 4e-136 455.1 11.1 2.0 1 1 1 2 2 2 2 Nop14-like family PCI PF01399.22 KOH00226.1 - 1.9e-23 82.7 1.4 5.7e-23 81.2 0.1 2.4 2 0 0 2 2 2 1 PCI domain DUF2013 PF09431.5 KOH00227.1 - 5.6e-47 159.0 10.2 5.6e-47 159.0 7.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) Coatomer_WDAD PF04053.9 KOH00228.1 - 8.3e-138 459.8 3.7 1.2e-137 459.3 2.5 1.3 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.6 KOH00228.1 - 3.3e-68 230.1 0.0 4.9e-68 229.5 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.27 KOH00228.1 - 3.3e-56 185.2 14.2 4.1e-10 39.1 0.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat eIF2A PF08662.6 KOH00228.1 - 1.3e-06 28.3 0.8 0.015 15.0 0.0 3.9 3 1 0 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 KOH00228.1 - 5.1e-06 24.9 6.0 0.18 9.9 0.1 3.7 2 1 1 3 3 3 3 Nucleoporin Nup120/160 TPR_2 PF07719.12 KOH00228.1 - 1.2 9.2 3.8 0.7 9.9 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ApbA_C PF08546.6 KOH00229.1 - 1.5e-27 96.0 0.0 2.3e-27 95.4 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 KOH00229.1 - 2.2e-20 72.6 0.0 3.3e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.16 KOH00229.1 - 0.021 14.6 0.9 0.065 13.0 0.2 2.0 2 0 0 2 2 2 0 ThiF family Phenol_hyd_sub PF06099.6 KOH00229.1 - 0.13 12.1 0.1 0.33 10.8 0.1 1.7 1 0 0 1 1 1 0 Phenol hydroxylase subunit Cpn60_TCP1 PF00118.19 KOH00230.1 - 9.8e-135 449.8 11.3 1.2e-134 449.5 7.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DeoC PF01791.4 KOH00230.1 - 0.03 13.6 1.3 0.95 8.7 0.1 2.9 3 0 0 3 3 3 0 DeoC/LacD family aldolase CDP-OH_P_transf PF01066.16 KOH00231.1 - 2.8e-17 62.8 1.9 2.8e-17 62.8 1.3 2.0 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase TctB PF07331.6 KOH00231.1 - 0.024 14.3 0.1 0.045 13.4 0.1 1.5 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family BPL_N PF09825.4 KOH00232.1 - 9.7e-142 472.0 0.0 1.2e-141 471.7 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.14 KOH00232.1 - 1.4e-18 67.0 0.2 1.8e-17 63.4 0.1 2.3 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.12 KOH00232.1 - 9.7e-16 57.1 0.0 2.2e-15 56.0 0.0 1.7 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain RNA_pol_Rpb1_1 PF04997.7 KOH00233.1 - 2.2e-119 398.6 0.0 3.8e-119 397.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.12 KOH00233.1 - 1.7e-108 362.1 0.1 3e-108 361.2 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 KOH00233.1 - 1.5e-72 242.9 0.0 4.1e-72 241.5 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.9 KOH00233.1 - 4.9e-64 215.5 0.4 1.1e-63 214.4 0.3 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.13 KOH00233.1 - 1.1e-46 158.4 0.0 2.8e-46 157.1 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.7 KOH00233.1 - 7.4e-45 151.9 3.2 1.7e-44 150.7 2.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.12 KOH00233.1 - 6.3e-35 119.1 0.1 1.8e-34 117.7 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.8 KOH00233.1 - 2.6e-18 64.4 263.4 0.037 14.1 9.1 14.5 3 1 1 15 15 15 14 RNA polymerase Rpb1 C-terminal repeat NAC PF01849.13 KOH00233.1 - 1.1 8.8 4.3 22 4.6 0.7 2.6 2 0 0 2 2 2 0 NAC domain Sugar_tr PF00083.19 KOH00234.1 - 2e-128 428.7 27.7 2.5e-128 428.5 19.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOH00234.1 - 5.1e-22 78.0 41.4 9.2e-14 50.9 10.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Arf PF00025.16 KOH00235.1 - 1.1e-77 259.2 0.0 1.2e-77 259.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KOH00235.1 - 3.1e-14 52.6 0.0 3.4e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 KOH00235.1 - 8.9e-14 51.1 0.0 1.1e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 KOH00235.1 - 1.1e-10 40.7 0.4 1.3e-07 30.6 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 KOH00235.1 - 1.6e-10 40.5 0.0 1.9e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 KOH00235.1 - 3.7e-10 40.3 0.0 5e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 KOH00235.1 - 1.2e-05 25.1 0.0 1.8e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOH00235.1 - 0.0045 16.4 0.0 0.021 14.2 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRP54 PF00448.17 KOH00235.1 - 0.006 16.0 0.2 0.011 15.1 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_33 PF13671.1 KOH00235.1 - 0.0083 16.0 0.1 0.013 15.3 0.1 1.5 1 1 0 1 1 1 1 AAA domain NACHT PF05729.7 KOH00235.1 - 0.015 14.9 0.3 2 8.0 0.0 2.1 2 0 0 2 2 2 0 NACHT domain ABC_tran PF00005.22 KOH00235.1 - 0.033 14.4 0.0 0.059 13.6 0.0 1.5 1 1 0 1 1 1 0 ABC transporter 6PF2K PF01591.13 KOH00235.1 - 0.038 13.0 0.1 0.06 12.4 0.1 1.5 1 1 0 1 1 1 0 6-phosphofructo-2-kinase cobW PF02492.14 KOH00235.1 - 0.07 12.5 0.1 6.3 6.2 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.7 KOH00235.1 - 0.14 11.1 0.1 0.33 10.0 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin Rho_GDI PF02115.12 KOH00236.1 - 4.3e-69 231.9 3.5 4.7e-69 231.8 2.4 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Metallophos PF00149.23 KOH00237.1 - 2.8e-40 137.8 0.6 4.2e-40 137.2 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase MARVEL PF01284.18 KOH00238.1 - 0.073 12.8 3.6 0.15 11.8 2.5 1.5 1 0 0 1 1 1 0 Membrane-associating domain Cullin PF00888.17 KOH00239.1 - 5.4e-169 563.4 18.5 7.3e-169 563.0 12.8 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 KOH00239.1 - 2.1e-25 88.3 0.1 1e-24 86.1 0.1 2.3 1 0 0 1 1 1 1 Cullin protein neddylation domain Phage_rep_O PF04492.8 KOH00239.1 - 0.0062 16.7 1.2 0.9 9.7 0.0 3.4 3 0 0 3 3 3 1 Bacteriophage replication protein O Penicillinase_R PF03965.11 KOH00239.1 - 0.024 14.7 0.0 0.18 11.8 0.0 2.6 2 0 0 2 2 2 0 Penicillinase repressor HMGL-like PF00682.14 KOH00240.1 - 1.1e-43 149.6 0.1 1.2e-43 149.4 0.1 1.0 1 0 0 1 1 1 1 HMGL-like ADP_PFK_GK PF04587.10 KOH00240.1 - 0.013 13.7 0.0 0.017 13.3 0.0 1.1 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region IATP PF04568.7 KOH00241.1 - 8.5e-20 70.6 0.3 9.3e-20 70.5 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP DUF4140 PF13600.1 KOH00241.1 - 0.015 15.7 0.1 0.02 15.3 0.1 1.2 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) IncA PF04156.9 KOH00241.1 - 0.029 13.9 0.1 0.029 13.9 0.1 1.1 1 0 0 1 1 1 0 IncA protein AAA_23 PF13476.1 KOH00241.1 - 0.033 14.4 0.4 0.033 14.4 0.2 1.1 1 0 0 1 1 1 0 AAA domain NinG PF05766.7 KOH00241.1 - 0.12 12.1 3.0 0.14 11.8 2.1 1.1 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein ORF6C PF10552.4 KOH00241.1 - 0.12 12.0 1.7 0.17 11.6 1.2 1.2 1 0 0 1 1 1 0 ORF6C domain HTH_25 PF13413.1 KOH00241.1 - 0.21 11.2 0.8 0.29 10.8 0.6 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain DASH_Dad2 PF08654.5 KOH00241.1 - 0.44 10.5 2.8 0.53 10.3 2.0 1.1 1 0 0 1 1 1 0 DASH complex subunit Dad2 DivIC PF04977.10 KOH00241.1 - 0.8 9.2 5.7 1.1 8.7 3.9 1.3 1 0 0 1 1 1 0 Septum formation initiator Na_Ca_ex PF01699.19 KOH00243.1 - 2.6e-51 172.8 30.5 3.9e-26 91.3 5.2 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Cyclin_N PF00134.18 KOH00244.1 - 2.7e-13 49.6 0.0 5.2e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 KOH00244.1 - 3.5e-10 40.4 0.0 3.5e-10 40.4 0.0 1.7 2 0 0 2 2 2 1 Cyclin AAA PF00004.24 KOH00245.1 - 4.4e-98 324.6 0.0 5e-48 162.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 KOH00245.1 - 9.3e-20 70.3 0.4 3.1e-19 68.6 0.3 2.0 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 KOH00245.1 - 1.1e-13 51.5 0.0 2.8e-07 30.6 0.0 2.9 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 KOH00245.1 - 1.5e-13 50.3 0.0 1.4e-05 24.2 0.0 3.1 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 KOH00245.1 - 1.3e-12 47.6 1.5 2e-06 27.5 0.0 3.9 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOH00245.1 - 5.3e-12 46.0 0.0 0.0004 20.4 0.0 3.5 2 1 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.1 KOH00245.1 - 1.3e-11 44.5 0.0 5.8e-06 26.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 KOH00245.1 - 2.7e-11 44.3 0.1 0.0011 19.8 0.0 3.7 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.1 KOH00245.1 - 3.3e-10 40.2 3.9 0.0012 18.9 0.1 4.3 3 2 0 3 3 2 2 AAA domain TIP49 PF06068.8 KOH00245.1 - 2.9e-09 36.1 0.0 0.0012 17.6 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus CDC48_2 PF02933.12 KOH00245.1 - 1.6e-08 34.0 0.0 4.4e-08 32.6 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_14 PF13173.1 KOH00245.1 - 1.9e-08 34.2 0.0 0.004 17.0 0.0 3.1 3 0 0 3 3 3 2 AAA domain IstB_IS21 PF01695.12 KOH00245.1 - 8.7e-08 31.7 0.1 0.0074 15.7 0.0 2.9 3 0 0 3 3 2 2 IstB-like ATP binding protein AAA_19 PF13245.1 KOH00245.1 - 1.7e-07 30.8 0.9 0.025 14.3 0.0 3.0 2 0 0 2 2 2 2 Part of AAA domain RNA_helicase PF00910.17 KOH00245.1 - 2.4e-07 30.8 0.0 0.011 15.9 0.0 3.0 3 0 0 3 3 2 2 RNA helicase Mg_chelatase PF01078.16 KOH00245.1 - 4.3e-07 29.3 0.5 0.031 13.4 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 KOH00245.1 - 4.3e-07 29.2 0.3 0.011 14.8 0.0 3.1 3 0 0 3 3 3 2 Zeta toxin AAA_25 PF13481.1 KOH00245.1 - 4.8e-07 29.3 6.9 0.03 13.7 0.1 4.3 2 2 2 4 4 4 2 AAA domain AAA_24 PF13479.1 KOH00245.1 - 1.8e-06 27.7 0.1 0.11 12.0 0.0 3.3 3 0 0 3 3 3 2 AAA domain KaiC PF06745.8 KOH00245.1 - 2.6e-06 26.7 2.6 0.34 10.0 0.0 3.8 2 2 1 3 3 3 2 KaiC ABC_tran PF00005.22 KOH00245.1 - 7.2e-06 26.3 0.0 0.047 13.9 0.0 4.1 3 1 0 3 3 3 1 ABC transporter ResIII PF04851.10 KOH00245.1 - 8.7e-06 25.6 0.0 0.0098 15.7 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_18 PF13238.1 KOH00245.1 - 1.1e-05 25.7 0.0 0.19 12.0 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.1 KOH00245.1 - 1.2e-05 25.3 0.0 0.24 11.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.21 KOH00245.1 - 1.3e-05 24.7 0.1 0.13 11.7 0.0 3.5 3 1 0 3 3 2 2 Sigma-54 interaction domain PhoH PF02562.11 KOH00245.1 - 2.4e-05 23.6 0.5 0.12 11.6 0.1 2.5 2 0 0 2 2 2 2 PhoH-like protein Parvo_NS1 PF01057.12 KOH00245.1 - 2.8e-05 23.1 0.1 0.11 11.3 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_11 PF13086.1 KOH00245.1 - 3.4e-05 23.5 0.0 0.36 10.3 0.0 2.7 2 1 0 2 2 2 2 AAA domain Sigma54_activ_2 PF14532.1 KOH00245.1 - 4.4e-05 23.5 0.0 0.17 11.9 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain DUF815 PF05673.8 KOH00245.1 - 7.5e-05 21.7 0.0 0.11 11.4 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Vps4_C PF09336.5 KOH00245.1 - 0.00011 21.9 0.1 0.0013 18.5 0.0 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_3 PF07726.6 KOH00245.1 - 0.00012 21.6 0.0 0.66 9.5 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.13 KOH00245.1 - 0.00017 21.2 0.0 0.38 10.3 0.0 3.2 4 0 0 4 4 2 1 Bacterial dnaA protein NACHT PF05729.7 KOH00245.1 - 0.00021 21.0 0.1 1.7 8.3 0.0 3.5 3 0 0 3 3 3 1 NACHT domain Arch_ATPase PF01637.13 KOH00245.1 - 0.00034 20.3 1.8 0.64 9.6 0.0 3.9 3 2 2 5 5 3 1 Archaeal ATPase DUF2075 PF09848.4 KOH00245.1 - 0.00041 19.4 0.0 0.69 8.8 0.0 2.6 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 KOH00245.1 - 0.00067 19.2 0.9 1.6 8.2 0.0 3.1 3 0 0 3 3 2 2 AAA domain NB-ARC PF00931.17 KOH00245.1 - 0.0046 15.8 0.1 1.8 7.3 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain NTPase_1 PF03266.10 KOH00245.1 - 0.0086 15.7 1.2 3.4 7.3 0.0 4.1 4 0 0 4 4 4 0 NTPase IPT PF01745.11 KOH00245.1 - 0.014 14.5 0.1 1.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase KAP_NTPase PF07693.9 KOH00245.1 - 0.018 14.0 0.2 1.6 7.6 0.0 2.9 2 2 1 3 3 3 0 KAP family P-loop domain Zot PF05707.7 KOH00245.1 - 0.023 14.1 0.3 5.8 6.3 0.0 3.6 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) SKI PF01202.17 KOH00245.1 - 0.053 13.3 0.0 4.7 7.0 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase UPF0079 PF02367.12 KOH00245.1 - 0.056 13.0 0.1 6.6 6.3 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 UFD1 PF03152.9 KOH00245.1 - 0.077 12.1 0.0 0.52 9.4 0.0 1.9 1 1 1 2 2 2 0 Ubiquitin fusion degradation protein UFD1 DEAD PF00270.24 KOH00245.1 - 0.18 11.3 0.3 25 4.3 0.0 3.3 3 1 1 4 4 4 0 DEAD/DEAH box helicase HIT PF01230.18 KOH00246.1 - 1.7e-09 38.0 0.2 2.3e-09 37.6 0.2 1.2 1 0 0 1 1 1 1 HIT domain DUF4566 PF15130.1 KOH00246.1 - 0.12 11.5 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4566) Pmp3 PF01679.12 KOH00247.1 - 1.8e-19 69.1 6.0 2.6e-19 68.6 4.1 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator ABC2_membrane_4 PF12730.2 KOH00247.1 - 0.0024 17.0 1.0 0.0029 16.8 0.7 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein UCH PF00443.24 KOH00248.1 - 5.2e-49 166.7 3.5 9.4e-49 165.9 2.4 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOH00248.1 - 1.9e-08 34.1 12.4 8.6e-05 22.1 1.0 3.8 4 0 0 4 4 4 3 Ubiquitin carboxyl-terminal hydrolase Mso1_Sec1_bdg PF14475.1 KOH00249.1 - 0.0099 15.2 0.3 0.0099 15.2 0.2 1.6 2 0 0 2 2 2 1 Sec1-binding region of Mso1 Frataxin_Cyay PF01491.11 KOH00250.1 - 3.6e-33 113.6 0.0 4.4e-33 113.3 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain Mito_carr PF00153.22 KOH00251.1 - 4.1e-53 177.0 2.0 3.7e-19 68.2 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein SH3_9 PF14604.1 KOH00252.1 - 3.1e-05 23.4 0.0 6.8e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 KOH00252.1 - 3.5e-05 23.1 0.0 8.5e-05 21.8 0.0 1.7 1 0 0 1 1 1 1 SH3 domain Transglut_core PF01841.14 KOH00252.1 - 0.00049 20.2 0.0 0.001 19.2 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_2 PF07653.12 KOH00252.1 - 0.00059 19.2 0.1 0.0013 18.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SCIMP PF15050.1 KOH00252.1 - 4.7 7.1 13.5 0.5 10.2 3.1 2.9 2 1 1 3 3 3 0 SCIMP protein Nup84_Nup100 PF04121.8 KOH00253.1 - 2.4e-237 789.0 22.8 2.8e-237 788.8 15.8 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 DUF1762 PF08574.5 KOH00254.1 - 4.6e-21 75.0 13.1 4.6e-21 75.0 9.1 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1762) DUF4535 PF15054.1 KOH00254.1 - 0.072 12.4 0.3 0.2 11.0 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4535) adh_short PF00106.20 KOH00255.1 - 2.5e-28 99.1 0.0 3.2e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOH00255.1 - 4.9e-10 39.3 0.0 1.9e-09 37.4 0.0 1.8 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 KOH00255.1 - 1.5e-09 38.0 0.0 2.2e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 KOH00255.1 - 0.00067 19.1 0.0 0.0013 18.1 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KOH00255.1 - 0.0079 14.9 0.1 0.011 14.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family HHV6-IE PF03753.8 KOH00255.1 - 0.035 11.6 0.2 0.048 11.1 0.2 1.1 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein PX PF00787.19 KOH00256.1 - 1e-22 80.0 0.1 1e-22 80.0 0.0 2.4 3 0 0 3 3 3 1 PX domain Vps5 PF09325.5 KOH00256.1 - 0.0049 16.1 21.6 0.0053 16.0 2.5 2.8 3 0 0 3 3 3 2 Vps5 C terminal like SpoU_methylase PF00588.14 KOH00257.1 - 7.3e-26 90.7 0.0 1.6e-25 89.6 0.0 1.6 1 0 0 1 1 1 1 SpoU rRNA Methylase family RNase_PH PF01138.16 KOH00258.1 - 1.6e-12 47.8 0.2 2.3e-12 47.3 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 KOH00258.1 - 0.0004 20.2 0.0 0.001 18.9 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Med9 PF07544.8 KOH00259.1 - 0.03 14.0 0.1 0.067 12.9 0.1 1.7 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Streptin-Immun PF11083.3 KOH00259.1 - 0.037 14.0 0.9 0.23 11.4 0.2 2.2 2 0 0 2 2 2 0 Lantibiotic streptin immunity protein Use1 PF09753.4 KOH00259.1 - 0.042 13.2 1.2 0.11 11.8 0.8 1.7 1 1 1 2 2 2 0 Membrane fusion protein Use1 IncA PF04156.9 KOH00259.1 - 0.061 12.9 0.4 0.07 12.7 0.3 1.1 1 0 0 1 1 1 0 IncA protein Cluap1 PF10234.4 KOH00259.1 - 0.067 12.3 0.1 0.11 11.6 0.1 1.4 1 0 0 1 1 1 0 Clusterin-associated protein-1 APG6 PF04111.7 KOH00259.1 - 0.088 11.8 0.9 0.11 11.5 0.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc7 PF08317.6 KOH00259.1 - 0.11 11.0 2.4 0.14 10.7 1.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein ISG65-75 PF11727.3 KOH00259.1 - 0.31 10.0 5.0 0.43 9.5 3.4 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein DUF676 PF05057.9 KOH00260.1 - 2.6e-61 206.7 0.1 4.7e-61 205.8 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.20 KOH00260.1 - 0.0013 18.3 0.0 0.0044 16.6 0.0 1.9 1 1 1 2 2 2 1 Lipase (class 3) PGAP1 PF07819.8 KOH00260.1 - 0.023 14.2 0.0 0.058 12.9 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.2 KOH00260.1 - 0.056 13.2 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pkinase PF00069.20 KOH00261.1 - 6.3e-60 202.5 0.0 7.1e-60 202.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00261.1 - 1.3e-23 83.3 0.0 2.5e-23 82.5 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 KOH00261.1 - 0.00026 20.7 0.0 0.00038 20.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOH00261.1 - 0.0063 15.5 0.0 0.0085 15.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Dexa_ind PF15198.1 KOH00261.1 - 0.12 12.2 0.2 0.39 10.6 0.1 1.8 2 0 0 2 2 2 0 Dexamethasone-induced TPR_11 PF13414.1 KOH00262.1 - 1.3e-06 27.9 3.8 1.1e-05 25.0 0.4 2.8 2 1 1 3 3 3 1 TPR repeat TPR_19 PF14559.1 KOH00262.1 - 4e-05 23.8 0.1 0.11 12.7 0.2 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOH00262.1 - 7.5e-05 23.2 0.1 0.02 15.5 0.0 2.1 1 1 2 3 3 2 2 Tetratricopeptide repeat Apc3 PF12895.2 KOH00262.1 - 0.0028 17.7 4.5 0.45 10.6 0.3 3.1 2 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 KOH00262.1 - 0.0035 17.1 6.5 0.041 13.8 0.1 4.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOH00262.1 - 0.0046 16.6 1.7 0.0046 16.6 1.2 5.3 5 1 0 5 5 5 1 Tetratricopeptide repeat vWA-TerF-like PF10138.4 KOH00262.1 - 0.0096 15.7 1.2 0.045 13.5 0.4 2.0 1 1 1 2 2 2 1 vWA found in TerF C terminus TPR_12 PF13424.1 KOH00262.1 - 0.011 15.6 1.8 0.14 12.1 0.1 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat SGS PF05002.10 KOH00262.1 - 0.058 13.1 0.4 6.7 6.5 0.0 2.4 2 0 0 2 2 2 0 SGS domain TPR_7 PF13176.1 KOH00262.1 - 0.073 12.9 1.6 0.37 10.6 0.0 2.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Cytokin_check_N PF10407.4 KOH00262.1 - 0.11 12.1 6.0 0.28 10.8 0.1 3.7 3 1 1 4 4 4 0 Cdc14 phosphatase binding protein N-terminus TPR_1 PF00515.23 KOH00262.1 - 6.2 6.6 12.9 0.11 12.1 0.6 3.8 5 0 0 5 5 4 0 Tetratricopeptide repeat Homeobox PF00046.24 KOH00263.1 - 1.3e-17 63.1 0.5 2.7e-17 62.1 0.3 1.6 1 0 0 1 1 1 1 Homeobox domain Nse4_C PF08743.5 KOH00264.1 - 3.4e-24 84.6 2.1 8.8e-24 83.3 0.1 2.7 2 0 0 2 2 2 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.1 KOH00264.1 - 2.9e-14 52.6 0.8 7.5e-14 51.3 0.5 1.7 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE LemA PF04011.7 KOH00264.1 - 0.0059 15.7 0.2 0.0059 15.7 0.1 1.7 2 0 0 2 2 2 1 LemA family Peptidase_M22 PF00814.20 KOH00265.1 - 1.1e-73 248.0 0.0 1.3e-73 247.8 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family BcrAD_BadFG PF01869.15 KOH00265.1 - 0.058 12.6 0.0 0.094 12.0 0.0 1.2 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family UDPGP PF01704.13 KOH00266.1 - 2.2e-46 158.2 0.0 3e-46 157.7 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.2 KOH00266.1 - 0.041 13.9 0.0 0.073 13.1 0.0 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain DNA_pol_B PF00136.16 KOH00267.1 - 3.7e-135 451.3 0.7 5.1e-135 450.8 0.5 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 KOH00267.1 - 2.1e-93 312.7 0.3 3.8e-93 311.9 0.2 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 KOH00267.1 - 2.4e-22 78.7 6.1 4.9e-22 77.7 4.2 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.8 KOH00267.1 - 0.00018 20.3 3.0 0.001 17.8 0.3 2.3 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.4 KOH00267.1 - 0.001 18.6 0.1 0.0028 17.2 0.0 1.7 2 0 0 2 2 2 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 KOH00267.1 - 0.0026 17.5 0.3 0.016 14.9 0.2 2.4 1 1 0 1 1 1 1 RNase_H superfamily Pkinase PF00069.20 KOH00268.1 - 1e-72 244.4 0.0 1.4e-72 243.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00268.1 - 2.2e-36 125.2 0.0 3.1e-36 124.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 KOH00268.1 - 4.1e-18 65.2 1.5 8.5e-18 64.2 0.4 2.0 2 0 0 2 2 2 1 FHA domain Kinase-like PF14531.1 KOH00268.1 - 0.00044 19.2 5.1 0.67 8.8 1.2 3.6 2 2 1 3 3 3 2 Kinase-like Kdo PF06293.9 KOH00268.1 - 0.0056 15.7 0.0 0.0098 14.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 KOH00268.1 - 0.053 12.8 0.8 0.12 11.6 0.5 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL ArsA_ATPase PF02374.10 KOH00269.1 - 1.3e-119 398.7 0.0 1.6e-119 398.5 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.18 KOH00269.1 - 1.1e-12 47.7 0.2 1.7e-12 47.1 0.1 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 KOH00269.1 - 0.00056 19.8 0.0 0.0044 16.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain Fer4_NifH PF00142.13 KOH00269.1 - 0.0014 17.8 0.0 0.0029 16.8 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.17 KOH00269.1 - 0.014 14.8 0.0 0.21 11.0 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.1 KOH00269.1 - 0.029 13.7 0.0 0.064 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Plasmodium_Vir PF05795.6 KOH00269.1 - 0.06 12.5 0.1 0.08 12.1 0.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PhoH PF02562.11 KOH00269.1 - 0.066 12.4 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.7 KOH00269.1 - 0.073 12.7 0.1 0.2 11.3 0.0 1.8 2 0 0 2 2 2 0 NACHT domain T2SE PF00437.15 KOH00269.1 - 0.17 10.7 0.0 0.31 9.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Reo_sigmaC PF04582.7 KOH00270.1 - 0.0081 15.3 1.8 0.012 14.7 1.2 1.2 1 0 0 1 1 1 1 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.7 KOH00270.1 - 0.084 12.6 5.2 0.15 11.8 3.6 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus PolyA_pol PF01743.15 KOH00270.1 - 3 8.0 13.6 0.18 12.0 4.3 2.9 2 1 1 3 3 3 0 Poly A polymerase head domain Daxx PF03344.10 KOH00270.1 - 7.5 4.9 44.8 13 4.1 31.0 1.3 1 0 0 1 1 1 0 Daxx Family zf-C2H2_jaz PF12171.3 KOH00271.1 - 3.3e-05 23.8 1.0 6.9e-05 22.8 0.7 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KOH00271.1 - 4.4e-05 23.5 1.0 9.8e-05 22.4 0.7 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type SRP-alpha_N PF04086.8 KOH00271.1 - 0.0003 20.2 1.2 0.0003 20.2 0.8 1.6 2 0 0 2 2 2 1 Signal recognition particle, alpha subunit, N-terminal zf-C2H2_6 PF13912.1 KOH00271.1 - 0.044 13.7 0.6 0.082 12.8 0.4 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_4 PF13894.1 KOH00271.1 - 0.15 12.4 0.7 0.41 11.0 0.5 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger PCI PF01399.22 KOH00272.1 - 3.8e-18 65.7 1.9 7e-18 64.8 0.0 2.4 3 0 0 3 3 3 1 PCI domain TPR_16 PF13432.1 KOH00272.1 - 4.2e-06 27.2 0.6 0.013 16.1 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.1 KOH00272.1 - 2.6e-05 23.4 2.5 6.3e-05 22.1 1.7 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat Apc3 PF12895.2 KOH00272.1 - 0.015 15.3 2.1 0.015 15.3 1.5 4.4 4 1 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 KOH00272.1 - 0.019 14.9 6.3 0.69 9.8 0.5 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat DDRGK PF09756.4 KOH00272.1 - 0.024 14.0 0.2 0.024 14.0 0.1 2.0 2 0 0 2 2 2 0 DDRGK domain TPR_21 PF09976.4 KOH00272.1 - 0.032 14.1 2.6 2.9 7.8 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOH00272.1 - 0.12 12.7 6.7 12 6.2 0.3 4.0 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOH00272.1 - 0.68 10.0 12.1 3.3 7.8 0.2 5.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_3 PF07720.7 KOH00272.1 - 3.7 7.4 8.2 13 5.6 0.3 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOH00272.1 - 4.1 8.0 9.1 3.9 8.1 0.1 4.5 6 0 0 6 6 4 0 Tetratricopeptide repeat Rapamycin_bind PF08771.6 KOH00272.1 - 5.6 7.1 6.7 38 4.4 0.1 4.1 4 2 1 5 5 5 0 Rapamycin binding domain PMT PF02366.13 KOH00273.1 - 7.4e-88 294.0 22.3 7.4e-88 294.0 15.5 2.1 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 KOH00273.1 - 8.7e-56 188.4 0.2 1.6e-55 187.6 0.1 1.4 1 0 0 1 1 1 1 MIR domain PMT PF02366.13 KOH00274.1 - 4.8e-72 242.2 19.4 4.8e-72 242.2 13.4 2.4 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 KOH00274.1 - 1.3e-55 187.8 0.1 1.9e-55 187.3 0.0 1.2 1 0 0 1 1 1 1 MIR domain SRP14 PF02290.10 KOH00275.1 - 9.2e-26 89.5 0.0 9.2e-26 89.5 0.0 1.6 2 0 0 2 2 2 1 Signal recognition particle 14kD protein UBX PF00789.15 KOH00276.1 - 8.6e-21 73.8 0.0 1.8e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 UBX domain DUF2418 PF10332.4 KOH00277.1 - 4.2e-23 81.5 1.3 1.2e-22 80.0 0.9 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) Nup35_RRM PF05172.8 KOH00278.1 - 2.7e-37 126.5 1.0 9.6e-37 124.7 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.1 KOH00278.1 - 1.9e-06 27.5 0.1 0.00012 21.7 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif LUC7 PF03194.10 KOH00279.1 - 9.5e-78 261.2 5.5 1e-77 261.0 3.8 1.0 1 0 0 1 1 1 1 LUC7 N_terminus DUF1104 PF06518.6 KOH00279.1 - 0.05 13.7 0.2 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1104) DLH PF01738.13 KOH00280.1 - 6.3e-22 77.9 0.0 7.3e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 KOH00280.1 - 4.8e-05 23.1 0.0 6.3e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOH00280.1 - 0.0012 18.0 0.0 0.027 13.6 0.0 2.3 3 0 0 3 3 3 1 Prolyl oligopeptidase family 6PF2K PF01591.13 KOH00280.1 - 0.023 13.7 0.0 0.032 13.3 0.0 1.1 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Chlorophyllase2 PF12740.2 KOH00280.1 - 0.031 13.1 0.0 0.039 12.8 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Chlorophyllase PF07224.6 KOH00280.1 - 0.07 11.9 0.1 0.1 11.3 0.1 1.2 1 0 0 1 1 1 0 Chlorophyllase DUF2305 PF10230.4 KOH00280.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) 4F5 PF04419.9 KOH00281.1 - 1e-07 32.5 13.1 1e-07 32.5 9.1 2.6 3 1 0 3 3 3 1 4F5 protein family Pex24p PF06398.6 KOH00281.1 - 0.0096 14.7 0.0 0.01 14.6 0.0 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Joubert PF15392.1 KOH00281.1 - 0.019 14.2 2.4 0.024 13.8 1.6 1.1 1 0 0 1 1 1 0 Joubert syndrome-associated Creatininase PF02633.9 KOH00281.1 - 0.098 11.7 0.4 0.12 11.3 0.2 1.1 1 0 0 1 1 1 0 Creatinine amidohydrolase CDC37_N PF03234.9 KOH00281.1 - 0.2 11.9 6.6 6.7 7.0 3.1 2.1 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding DUF4407 PF14362.1 KOH00281.1 - 2.1 7.2 7.9 2.5 6.9 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pyr_redox_2 PF07992.9 KOH00282.1 - 4.3e-23 82.2 0.0 3.9e-14 52.9 0.0 3.6 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOH00282.1 - 1.9e-11 44.2 0.0 9e-10 38.8 0.0 2.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOH00282.1 - 8.8e-06 25.9 0.0 0.0022 18.0 0.0 3.2 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Sugar-bind PF04198.8 KOH00282.1 - 0.16 10.8 0.0 0.32 9.8 0.0 1.5 1 0 0 1 1 1 0 Putative sugar-binding domain DEAD PF00270.24 KOH00283.1 - 3.9e-35 120.8 0.2 1.2e-34 119.1 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOH00283.1 - 8.9e-23 79.9 0.0 1e-21 76.5 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOH00283.1 - 1.2e-05 25.2 0.1 3.8e-05 23.6 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Ribosomal_L13e PF01294.13 KOH00284.1 - 2.7e-73 245.2 6.0 3.4e-73 244.9 4.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Ribosomal_60s PF00428.14 KOH00285.1 - 1.6e-21 76.5 5.8 1.9e-21 76.2 4.0 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein TPP_enzyme_N PF02776.13 KOH00286.1 - 3.9e-28 98.0 0.0 5.8e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 KOH00286.1 - 4.1e-25 88.1 0.0 8e-25 87.1 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 KOH00286.1 - 1.2e-14 54.2 0.0 1.9e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Ldh_1_C PF02866.13 KOH00287.1 - 2.4e-51 173.8 0.1 3.3e-51 173.4 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 KOH00287.1 - 1.3e-43 148.2 0.1 2.2e-43 147.4 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.19 KOH00287.1 - 0.00042 20.6 0.1 0.0014 18.9 0.0 2.0 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 KOH00287.1 - 0.041 12.5 0.0 0.058 12.0 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Vps39_1 PF10366.4 KOH00288.1 - 2.7e-34 117.4 2.8 4.9e-34 116.5 0.3 2.9 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.4 KOH00288.1 - 6.6e-12 45.5 0.0 1.7e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 DUF3330 PF11809.3 KOH00288.1 - 0.015 15.1 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3330) Rxt3 PF08642.5 KOH00289.1 - 2e-34 118.2 0.0 4.3e-34 117.1 0.0 1.5 2 0 0 2 2 2 1 Histone deacetylation protein Rxt3 Ribosomal_L31e PF01198.14 KOH00290.1 - 1.4e-36 123.9 1.5 1.7e-36 123.7 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e BRE1 PF08647.6 KOH00291.1 - 1.2e-31 108.5 10.0 1.2e-31 108.5 6.9 6.2 4 2 2 6 6 4 1 BRE1 E3 ubiquitin ligase zf-C3HC4_2 PF13923.1 KOH00291.1 - 1.7e-06 27.9 13.8 3.4e-06 26.9 9.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOH00291.1 - 3.3e-06 26.6 11.9 6.2e-06 25.7 8.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOH00291.1 - 1.5e-05 24.6 13.8 2.9e-05 23.6 9.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 KOH00291.1 - 5.2e-05 22.8 14.4 0.00011 21.7 10.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOH00291.1 - 0.0018 18.0 11.1 0.0037 17.0 7.7 1.6 1 0 0 1 1 1 1 Ring finger domain Pox_A_type_inc PF04508.7 KOH00291.1 - 0.0031 17.1 7.4 4.6 7.2 0.5 6.2 4 0 0 4 4 4 1 Viral A-type inclusion protein repeat zf-C2H2 PF00096.21 KOH00291.1 - 0.0045 17.2 0.2 0.0045 17.2 0.1 2.6 2 0 0 2 2 1 1 Zinc finger, C2H2 type DUF3410 PF11890.3 KOH00291.1 - 0.026 14.1 2.1 0.09 12.4 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3410) Prok-RING_4 PF14447.1 KOH00291.1 - 0.026 14.0 5.2 0.061 12.8 3.6 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.1 KOH00291.1 - 0.028 14.1 8.2 0.14 11.8 5.7 2.4 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_6 PF14835.1 KOH00291.1 - 0.029 14.1 4.5 0.068 12.9 3.1 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.1 KOH00291.1 - 3 7.5 11.7 6.2 6.4 8.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 KOH00291.1 - 5.5 6.9 10.7 17 5.4 7.4 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF1765 PF08578.5 KOH00292.1 - 1.1e-24 86.8 6.4 4e-24 85.0 4.4 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) Bap31 PF05529.7 KOH00293.1 - 3.6e-58 196.1 0.5 4.1e-58 196.0 0.3 1.0 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like BofA PF07441.6 KOH00293.1 - 0.016 15.1 0.2 0.016 15.1 0.1 2.2 3 0 0 3 3 3 0 SigmaK-factor processing regulatory protein BofA Spc24 PF08286.6 KOH00293.1 - 0.058 13.0 1.2 0.098 12.3 0.8 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Bromodomain PF00439.20 KOH00294.1 - 3.6e-39 132.5 2.1 7.3e-21 73.8 0.2 2.7 2 0 0 2 2 2 2 Bromodomain ENTH PF01417.15 KOH00295.1 - 0.027 14.3 0.1 0.027 14.3 0.1 2.2 2 1 0 2 2 2 0 ENTH domain Imm30 PF15594.1 KOH00295.1 - 0.23 11.5 2.9 0.35 10.9 1.3 1.9 1 1 0 2 2 2 0 Immunity protein 30 FSH1 PF03959.8 KOH00296.1 - 0.0078 15.6 0.0 0.0078 15.6 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Iso_dh PF00180.15 KOH00297.1 - 8.2e-70 235.4 0.0 9.6e-70 235.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PhoU_div PF01865.11 KOH00297.1 - 0.063 12.4 0.1 0.14 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF47 DUF925 PF06042.6 KOH00297.1 - 0.098 12.2 0.1 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF925) Pex19 PF04614.7 KOH00298.1 - 1.5e-64 218.0 9.0 1.5e-64 218.0 6.2 1.4 1 1 1 2 2 2 1 Pex19 protein family Colicin_Pyocin PF01320.13 KOH00298.1 - 0.092 12.6 1.9 1.4 8.7 0.1 2.8 3 0 0 3 3 3 0 Colicin immunity protein / pyocin immunity protein XPC-binding PF09280.6 KOH00298.1 - 0.16 11.4 1.5 0.81 9.1 0.3 2.7 3 0 0 3 3 3 0 XPC-binding domain BCDHK_Adom3 PF10436.4 KOH00298.1 - 0.29 10.6 2.5 3.6 7.0 0.0 2.6 2 1 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase D5_N PF08706.6 KOH00298.1 - 0.3 11.1 3.0 8.3 6.4 0.2 3.2 1 1 1 2 2 2 0 D5 N terminal like HEAT_2 PF13646.1 KOH00299.1 - 0.026 14.8 0.0 3.1 8.1 0.0 2.8 2 0 0 2 2 2 0 HEAT repeats Ribosomal_S14 PF00253.16 KOH00300.1 - 6.6e-18 63.8 4.7 7.2e-18 63.7 3.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF4428 PF14471.1 KOH00300.1 - 0.045 13.5 0.1 0.051 13.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) Prim_Zn_Ribbon PF08273.7 KOH00300.1 - 0.11 12.5 2.2 1.6 8.8 0.2 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DUF2296 PF10058.4 KOH00300.1 - 0.17 11.6 1.7 8.2 6.2 1.8 2.1 1 1 1 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) RNA_POL_M_15KD PF02150.11 KOH00300.1 - 0.26 11.0 1.6 6.3 6.5 0.1 2.1 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit DUF663 PF04950.7 KOH00301.1 - 3e-108 361.2 0.0 7.6e-108 359.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 KOH00301.1 - 8.2e-25 86.1 0.0 2e-24 84.8 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Rad52_Rad22 PF04098.10 KOH00302.1 - 5.2e-45 152.9 0.1 6.6e-45 152.5 0.1 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein DUF2634 PF10934.3 KOH00302.1 - 0.013 15.2 0.4 0.037 13.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2634) Uso1_p115_head PF04869.9 KOH00303.1 - 1.9e-106 355.4 4.2 1.9e-106 355.4 2.9 2.5 3 0 0 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.8 KOH00303.1 - 1.7e-20 73.3 28.6 1.7e-20 73.3 19.8 13.2 2 1 8 11 11 11 1 Uso1 / p115 like vesicle tethering protein, C terminal region IncA PF04156.9 KOH00303.1 - 0.0015 18.1 29.8 0.0015 18.1 20.6 11.7 1 1 9 10 10 10 3 IncA protein Reo_sigmaC PF04582.7 KOH00303.1 - 0.0023 17.1 91.3 0.031 13.4 6.4 8.5 1 1 7 9 9 9 5 Reovirus sigma C capsid protein DUF3584 PF12128.3 KOH00303.1 - 0.016 12.6 214.8 0.0023 15.3 42.4 5.6 1 1 3 5 5 5 0 Protein of unknown function (DUF3584) AAA_13 PF13166.1 KOH00303.1 - 8.1 4.7 227.4 0.039 12.4 27.2 6.9 1 1 5 6 6 6 0 AAA domain Abhydrolase_5 PF12695.2 KOH00304.1 - 9.4e-15 54.6 0.0 1.7e-14 53.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOH00304.1 - 2.5e-12 47.1 0.0 1.9e-11 44.2 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 KOH00304.1 - 2.1e-07 30.6 0.0 4.3e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Peptidase_S15 PF02129.13 KOH00304.1 - 0.054 12.9 0.0 0.25 10.7 0.0 1.9 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Ank_4 PF13637.1 KOH00305.1 - 1e-12 48.1 0.1 4.2e-07 30.3 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOH00305.1 - 3e-12 46.3 0.0 6.7e-05 23.0 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOH00305.1 - 6.3e-12 45.6 0.0 4.9e-06 26.7 0.0 3.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) KilA-N PF04383.8 KOH00305.1 - 3e-08 33.2 1.7 1.2e-07 31.3 0.2 2.7 2 1 0 2 2 2 1 KilA-N domain Ank PF00023.25 KOH00305.1 - 8.1e-08 31.7 0.2 0.0058 16.3 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 KOH00305.1 - 2.5e-05 24.1 0.5 0.027 14.7 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat NTP_transferase PF00483.18 KOH00306.1 - 5.1e-50 170.0 0.0 6.3e-50 169.7 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 KOH00306.1 - 4.7e-11 43.0 0.0 6.2e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.19 KOH00306.1 - 1.8e-09 36.6 7.3 7.9e-07 28.3 0.8 3.7 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 KOH00306.1 - 0.0032 17.0 4.6 0.039 13.5 0.2 3.2 4 0 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase CTP_transf_3 PF02348.14 KOH00306.1 - 0.037 13.6 0.0 0.064 12.8 0.0 1.5 1 0 0 1 1 1 0 Cytidylyltransferase MFS_1 PF07690.11 KOH00307.1 - 1.8e-15 56.5 24.7 2.9e-15 55.8 17.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DivIVA PF05103.8 KOH00308.1 - 0.014 15.4 1.0 0.019 14.9 0.0 1.7 2 0 0 2 2 2 0 DivIVA protein MRP-S25 PF13741.1 KOH00308.1 - 0.03 13.7 1.3 0.05 13.0 0.9 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein S25 Macoilin PF09726.4 KOH00308.1 - 0.39 8.9 9.1 0.43 8.8 6.3 1.1 1 0 0 1 1 1 0 Transmembrane protein Acyltransferase PF01553.16 KOH00309.1 - 1.3e-33 115.2 0.0 2.1e-33 114.5 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase La PF05383.12 KOH00310.1 - 4.9e-23 80.6 0.0 1.3e-22 79.3 0.0 1.8 1 0 0 1 1 1 1 La domain RRM_1 PF00076.17 KOH00310.1 - 1.5e-07 30.9 0.1 1e-06 28.2 0.1 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOH00310.1 - 0.00013 21.9 0.1 0.0011 18.9 0.1 2.4 2 1 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOH00310.1 - 0.0019 18.0 0.1 0.015 15.1 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) tRNA-synt_1g PF09334.6 KOH00310.1 - 0.0047 15.6 0.2 0.012 14.3 0.0 1.5 1 1 1 2 2 2 1 tRNA synthetases class I (M) BRAP2 PF07576.7 KOH00310.1 - 0.016 14.8 0.1 0.036 13.6 0.1 1.6 1 0 0 1 1 1 0 BRCA1-associated protein 2 RXT2_N PF08595.6 KOH00310.1 - 3.1 7.6 13.1 7.7 6.3 9.1 1.7 1 1 0 1 1 1 0 RXT2-like, N-terminal KRE9 PF05390.6 KOH00311.1 - 2.1e-57 192.0 6.8 4.6e-57 190.9 4.7 1.6 1 0 0 1 1 1 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.4 KOH00311.1 - 7.6e-10 39.1 0.7 7.6e-10 39.1 0.5 2.5 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family zf-C2H2_6 PF13912.1 KOH00312.1 - 1.5e-05 24.7 8.7 0.00057 19.6 0.1 4.2 3 1 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_4 PF13894.1 KOH00312.1 - 0.0001 22.3 19.9 0.0015 18.7 1.2 5.1 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.21 KOH00312.1 - 0.0011 19.1 1.8 0.0011 19.1 1.2 5.1 4 1 0 4 4 4 1 Zinc finger, C2H2 type Rad50_zn_hook PF04423.9 KOH00312.1 - 0.0023 17.3 1.5 0.1 12.0 0.1 2.8 2 0 0 2 2 2 1 Rad50 zinc hook motif zf-C2H2_jaz PF12171.3 KOH00312.1 - 0.0044 17.1 2.8 0.16 12.1 0.0 3.6 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 KOH00312.1 - 0.0047 17.1 2.2 0.0047 17.1 1.5 4.6 4 1 1 5 5 5 1 Zinc-finger double domain zf-RING_3 PF14369.1 KOH00312.1 - 1.1 9.3 3.9 4.9 7.2 0.2 3.3 3 0 0 3 3 3 0 zinc-finger zf-Di19 PF05605.7 KOH00312.1 - 1.2 9.3 10.4 0.47 10.6 3.3 3.2 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_5 PF14634.1 KOH00312.1 - 1.4 8.6 6.5 15 5.4 0.1 3.2 3 0 0 3 3 3 0 zinc-RING finger domain zf-met PF12874.2 KOH00312.1 - 6.4 7.1 7.8 0.64 10.3 0.2 3.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Metallophos PF00149.23 KOH00313.1 - 1.8e-43 148.2 0.2 2.3e-43 147.9 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOH00313.1 - 0.0021 17.9 0.0 0.0045 16.8 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DIL PF01843.14 KOH00313.1 - 0.12 12.2 0.1 0.4 10.5 0.0 1.8 2 0 0 2 2 2 0 DIL domain E1_DerP2_DerF2 PF02221.10 KOH00314.1 - 3.3e-26 92.1 0.0 3.8e-26 91.9 0.0 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.1 KOH00314.1 - 0.004 17.1 0.0 0.005 16.8 0.0 1.2 1 0 0 1 1 1 1 ML-like domain CHCH PF06747.8 KOH00315.1 - 6.4e-06 25.9 0.3 8.5e-06 25.5 0.2 1.2 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.5 KOH00315.1 - 0.00049 19.8 0.5 0.00057 19.6 0.4 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CMV_US PF08001.6 KOH00315.1 - 0.046 12.7 0.0 0.053 12.5 0.0 1.1 1 0 0 1 1 1 0 CMV US PAPS_reduct PF01507.14 KOH00316.1 - 7.3e-40 136.6 0.0 9.8e-40 136.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family DUF3730 PF12530.3 KOH00316.1 - 0.0053 16.7 0.0 0.0091 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3730) HTH_45 PF14947.1 KOH00316.1 - 0.13 12.0 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix zf-met PF12874.2 KOH00318.1 - 5.9e-06 26.3 1.5 5.9e-06 26.3 1.1 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-U1 PF06220.7 KOH00318.1 - 0.047 13.2 0.1 0.086 12.4 0.1 1.4 1 0 0 1 1 1 0 U1 zinc finger zf-C2H2_2 PF12756.2 KOH00318.1 - 0.059 13.4 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) DUF3505 PF12013.3 KOH00318.1 - 0.073 13.3 0.1 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3505) PAS_6 PF08348.6 KOH00318.1 - 0.073 12.6 0.1 0.97 9.0 0.0 2.1 2 0 0 2 2 2 0 YheO-like PAS domain SIR2 PF02146.12 KOH00319.1 - 2e-66 223.1 0.0 4.9e-66 221.8 0.0 1.7 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.8 KOH00319.1 - 5.5e-65 217.6 0.4 1.3e-64 216.3 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.17 KOH00319.1 - 0.0007 19.3 0.0 0.73 9.5 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain NARP1 PF12569.3 KOH00320.1 - 5.6e-116 388.3 22.8 1.3e-81 274.9 0.8 3.0 4 0 0 4 4 4 2 NMDA receptor-regulated protein 1 TPR_16 PF13432.1 KOH00320.1 - 3.2e-13 49.9 4.2 0.0022 18.6 0.1 6.9 8 1 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOH00320.1 - 9.3e-13 47.5 0.2 0.058 14.0 0.0 7.4 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOH00320.1 - 9.7e-13 46.9 8.2 0.014 15.2 0.0 7.5 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOH00320.1 - 9e-12 45.1 6.6 0.0052 17.0 0.0 5.8 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.1 KOH00320.1 - 8.5e-11 41.3 10.4 0.018 14.6 0.0 5.7 6 0 0 6 6 6 4 TPR repeat TPR_8 PF13181.1 KOH00320.1 - 1.2e-05 24.7 13.3 0.36 10.7 0.0 7.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOH00320.1 - 5.4e-05 23.0 9.2 5.3 7.4 0.0 7.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOH00320.1 - 9.5e-05 22.2 12.0 0.043 13.7 0.1 6.2 7 1 0 7 7 7 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOH00320.1 - 0.0092 15.8 7.3 1.6 8.6 0.2 4.7 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 KOH00320.1 - 0.056 13.9 7.9 1.5 9.4 0.0 6.3 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOH00320.1 - 0.1 12.2 15.8 0.28 10.8 0.0 7.8 11 1 1 12 12 12 0 Tetratricopeptide repeat PseudoU_synth_2 PF00849.17 KOH00321.1 - 7.8e-32 110.3 0.2 5.2e-31 107.6 0.0 2.2 2 0 0 2 2 2 1 RNA pseudouridylate synthase Git3 PF11710.3 KOH00322.1 - 2.7e-87 291.5 7.8 5e-87 290.6 5.4 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Git3_C PF11970.3 KOH00322.1 - 6.4e-32 109.1 2.6 6.4e-32 109.1 1.8 2.3 3 0 0 3 3 3 1 G protein-coupled glucose receptor regulating Gpa2 C-term Menin PF05053.8 KOH00322.1 - 0.035 12.2 8.4 0.056 11.6 5.9 1.2 1 0 0 1 1 1 0 Menin Neur_chan_memb PF02932.11 KOH00322.1 - 0.17 11.7 8.3 0.14 12.0 4.3 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PNTB PF02233.11 KOH00322.1 - 0.39 9.4 1.6 0.66 8.6 1.1 1.3 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit DEAD PF00270.24 KOH00323.1 - 1.4e-46 158.1 0.2 6.4e-46 155.9 0.0 2.1 2 1 0 2 2 2 1 DEAD/DEAH box helicase DBP10CT PF08147.7 KOH00323.1 - 2e-21 75.5 6.6 2e-21 75.5 4.6 3.1 3 0 0 3 3 3 1 DBP10CT (NUC160) domain Helicase_C PF00271.26 KOH00323.1 - 4.6e-21 74.4 0.0 1.7e-20 72.6 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF3449 PF11931.3 KOH00324.1 - 4.8e-65 218.7 0.4 4.8e-65 218.7 0.3 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) zf-C2H2_jaz PF12171.3 KOH00324.1 - 5.9e-11 42.1 1.9 1e-06 28.6 0.1 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KOH00324.1 - 1.2e-08 34.8 0.6 0.0012 18.9 0.0 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 KOH00324.1 - 0.0007 19.7 4.3 0.08 13.3 0.1 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.2 KOH00324.1 - 0.0041 17.1 3.4 0.13 12.3 0.2 2.7 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 KOH00324.1 - 0.019 15.2 2.4 3.6 8.1 0.3 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KOH00324.1 - 0.64 10.4 2.9 8.9 6.8 0.4 2.8 2 0 0 2 2 2 0 Zinc-finger double domain zf-DBF PF07535.7 KOH00324.1 - 1.1 8.9 7.3 1.4 8.6 0.1 2.5 2 0 0 2 2 2 0 DBF zinc finger Pkinase PF00069.20 KOH00325.1 - 9.7e-50 169.1 0.0 2.6e-49 167.7 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00325.1 - 7.5e-22 77.6 0.0 1.4e-21 76.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOH00325.1 - 0.0016 18.1 0.0 0.63 9.7 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family PerC PF06069.6 KOH00325.1 - 0.013 15.4 0.1 0.26 11.3 0.0 3.0 3 0 0 3 3 3 0 PerC transcriptional activator RIO1 PF01163.17 KOH00325.1 - 0.015 14.6 0.2 0.038 13.3 0.1 1.7 1 0 0 1 1 1 0 RIO1 family RseC_MucC PF04246.7 KOH00326.1 - 0.17 11.4 1.5 0.3 10.6 1.0 1.3 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Pkinase PF00069.20 KOH00327.1 - 1e-57 195.2 0.0 1.7e-57 194.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00327.1 - 3.4e-22 78.7 0.0 5.8e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOH00327.1 - 0.02 14.6 0.1 0.042 13.5 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 KOH00327.1 - 0.082 11.8 0.0 0.22 10.4 0.0 1.5 1 1 0 1 1 1 0 Kinase-like His_Phos_2 PF00328.17 KOH00328.1 - 9.2e-50 169.9 0.1 1.1e-49 169.6 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF1122 PF06557.6 KOH00328.1 - 0.043 12.9 0.0 0.19 10.8 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1122) NAD_Gly3P_dh_N PF01210.18 KOH00329.1 - 2.8e-53 179.8 0.1 4.3e-53 179.2 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.9 KOH00329.1 - 8e-47 158.7 0.0 1.2e-46 158.1 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus His_Phos_1 PF00300.17 KOH00330.1 - 1.7e-43 148.4 0.1 6.3e-43 146.5 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) zf-C2H2_4 PF13894.1 KOH00331.1 - 6.5e-06 26.1 5.8 0.022 15.0 0.1 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.21 KOH00331.1 - 0.0021 18.2 14.5 0.011 16.0 0.1 3.4 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 KOH00331.1 - 6.2 6.8 7.0 2.3 8.2 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger Oxysterol_BP PF01237.13 KOH00332.1 - 5.8e-134 446.0 0.7 1.1e-133 445.1 0.5 1.5 1 0 0 1 1 1 1 Oxysterol-binding protein Ank_2 PF12796.2 KOH00332.1 - 1.6e-13 50.7 0.1 1.3e-07 31.8 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOH00332.1 - 2.5e-12 46.5 0.1 7.4e-05 22.8 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 KOH00332.1 - 6.7e-11 41.4 0.0 7.9e-06 25.4 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOH00332.1 - 9.9e-10 38.6 0.0 0.00019 21.8 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) PH PF00169.24 KOH00332.1 - 1.5e-09 37.9 0.0 8.9e-09 35.4 0.0 2.5 1 0 0 1 1 1 1 PH domain Ank_3 PF13606.1 KOH00332.1 - 6.7e-09 35.1 0.2 0.00046 20.1 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat PH_8 PF15409.1 KOH00332.1 - 6.8e-06 26.0 0.0 2.2e-05 24.4 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.1 KOH00332.1 - 5.9e-05 23.2 2.6 8.4e-05 22.8 0.1 2.8 2 0 0 2 2 2 1 Pleckstrin homology domain Carn_acyltransf PF00755.15 KOH00333.1 - 1.5e-177 591.2 0.1 2.4e-177 590.6 0.0 1.3 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase EMP24_GP25L PF01105.19 KOH00334.1 - 6.8e-35 120.4 0.3 9.2e-35 120.0 0.2 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Syntaxin-6_N PF09177.6 KOH00334.1 - 0.018 15.4 0.8 0.03 14.7 0.6 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF999 PF06198.6 KOH00334.1 - 0.11 12.2 0.3 0.18 11.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF999) Pkinase PF00069.20 KOH00335.1 - 4.7e-41 140.6 0.0 1.1e-22 80.5 0.0 3.1 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00335.1 - 3.9e-14 52.3 0.0 1.2e-08 34.3 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.1 KOH00335.1 - 0.00022 20.2 0.0 0.49 9.3 0.0 2.7 3 0 0 3 3 3 2 Kinase-like APH PF01636.18 KOH00335.1 - 0.021 14.5 0.0 0.046 13.4 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Steroid_dh PF02544.11 KOH00336.1 - 1.6e-46 157.7 14.6 2.8e-46 156.9 10.1 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1304 PF06993.7 KOH00336.1 - 0.023 14.3 0.2 0.046 13.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1304) Fibrillarin PF01269.12 KOH00337.1 - 3.7e-110 366.2 0.0 4.5e-110 366.0 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 KOH00337.1 - 1.4e-05 24.7 0.1 2.8e-05 23.7 0.1 1.4 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.14 KOH00337.1 - 0.056 12.9 0.0 0.089 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) zf-C3HC4_2 PF13923.1 KOH00338.1 - 0.011 15.7 0.1 0.036 14.0 0.1 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOH00338.1 - 0.014 15.0 0.1 0.038 13.6 0.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOH00338.1 - 0.018 14.7 0.1 0.018 14.7 0.0 1.9 2 0 0 2 2 2 0 zinc-RING finger domain Fer2_3 PF13085.1 KOH00338.1 - 0.038 13.8 0.0 0.13 12.0 0.0 1.9 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain DUF1980 PF09323.5 KOH00338.1 - 0.11 12.1 0.5 0.23 11.2 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Glutaredoxin PF00462.19 KOH00339.1 - 1.4e-11 44.1 0.0 4.1e-11 42.7 0.0 1.8 1 0 0 1 1 1 1 Glutaredoxin zf-Apc11 PF12861.2 KOH00340.1 - 2.4e-46 155.5 6.6 3.2e-46 155.1 4.6 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 KOH00340.1 - 1.1e-30 105.5 7.9 1.6e-30 105.0 5.5 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 KOH00340.1 - 2.1e-07 30.6 16.1 9.4e-07 28.5 11.2 2.2 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KOH00340.1 - 0.00059 19.5 12.1 0.0056 16.3 8.8 2.2 1 1 1 2 2 2 1 zinc-RING finger domain CpXC PF14353.1 KOH00340.1 - 0.0066 16.4 0.6 0.0094 15.9 0.4 1.3 1 0 0 1 1 1 1 CpXC protein zf-C3HC4_2 PF13923.1 KOH00340.1 - 0.0068 16.4 13.5 0.049 13.6 9.4 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOH00340.1 - 0.014 15.0 14.5 0.11 12.1 10.1 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOH00340.1 - 0.029 14.0 12.5 1.2 8.8 8.7 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 KOH00340.1 - 0.19 11.3 14.1 0.068 12.7 1.5 3.0 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.3 KOH00340.1 - 0.62 9.6 4.9 1.5 8.4 3.4 1.7 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.3 KOH00340.1 - 0.67 9.9 15.8 11 6.0 10.9 3.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.6 KOH00340.1 - 0.9 9.5 11.6 5 7.2 8.0 2.2 1 1 0 1 1 1 0 RING-like domain DZR PF12773.2 KOH00340.1 - 0.97 9.3 10.6 48 3.8 7.4 2.3 1 1 0 1 1 1 0 Double zinc ribbon zf-HC5HC2H_2 PF13832.1 KOH00340.1 - 1.2 9.1 6.8 0.46 10.5 2.7 1.8 1 1 0 1 1 1 0 PHD-zinc-finger like domain RINGv PF12906.2 KOH00340.1 - 1.9 8.6 8.8 7.9 6.6 6.2 2.0 1 1 0 1 1 1 0 RING-variant domain zf-HIT PF04438.11 KOH00340.1 - 2.7 7.7 9.3 0.5 10.0 3.2 2.0 2 0 0 2 2 2 0 HIT zinc finger AAA PF00004.24 KOH00342.1 - 1.8e-40 138.1 0.0 3.1e-40 137.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOH00342.1 - 3.1e-06 27.3 0.1 0.0018 18.4 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.9 KOH00342.1 - 8.4e-06 25.7 0.0 2.5e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 KOH00342.1 - 2.1e-05 23.6 0.0 3.5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 KOH00342.1 - 0.00012 21.8 0.1 0.00054 19.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOH00342.1 - 0.00035 20.6 0.0 0.0013 18.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.7 KOH00342.1 - 0.0013 17.8 0.0 0.0024 16.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_28 PF13521.1 KOH00342.1 - 0.0016 18.4 0.5 0.0041 17.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 KOH00342.1 - 0.0038 17.1 0.0 0.0089 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOH00342.1 - 0.0057 16.9 0.1 0.023 14.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KOH00342.1 - 0.0057 17.4 0.7 0.013 16.2 0.1 2.0 2 1 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 KOH00342.1 - 0.007 15.8 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 KOH00342.1 - 0.0084 15.8 0.6 0.018 14.8 0.4 1.4 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 KOH00342.1 - 0.01 14.9 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_3 PF07726.6 KOH00342.1 - 0.011 15.3 0.0 0.027 14.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 KOH00342.1 - 0.012 15.4 0.0 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 KOH00342.1 - 0.013 14.3 0.0 0.047 12.5 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain TIP49 PF06068.8 KOH00342.1 - 0.022 13.4 0.0 0.04 12.6 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus NTPase_1 PF03266.10 KOH00342.1 - 0.024 14.3 0.1 0.12 12.0 0.0 2.2 2 0 0 2 2 2 0 NTPase PhoH PF02562.11 KOH00342.1 - 0.031 13.5 0.2 0.19 10.9 0.1 2.0 2 0 0 2 2 2 0 PhoH-like protein RNA_helicase PF00910.17 KOH00342.1 - 0.033 14.3 0.0 0.083 13.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.1 KOH00342.1 - 0.039 13.3 3.2 0.19 11.0 0.3 2.5 2 1 0 3 3 3 0 AAA domain Mg_chelatase PF01078.16 KOH00342.1 - 0.049 12.7 0.1 0.098 11.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 KOH00342.1 - 0.053 13.0 0.2 0.13 11.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KOH00342.1 - 0.069 12.8 0.1 0.32 10.6 0.1 2.0 2 0 0 2 2 2 0 NACHT domain PP2C PF00481.16 KOH00343.1 - 1.7e-78 263.5 0.4 4.3e-78 262.2 0.3 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOH00343.1 - 0.0007 19.3 0.1 0.003 17.2 0.1 1.9 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Med2 PF11214.3 KOH00344.1 - 3.5e-32 110.5 25.7 2.1e-30 104.8 17.8 2.9 1 1 0 1 1 1 1 Mediator complex subunit 2 ATP-synt_DE_N PF02823.11 KOH00345.1 - 3.2e-20 71.6 0.0 4.5e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Rad21_Rec8_N PF04825.8 KOH00346.1 - 5.4e-24 84.2 0.3 1.5e-23 82.8 0.2 1.7 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 KOH00346.1 - 1.1e-15 56.5 0.0 2e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 KOH00346.1 - 0.002 17.7 0.3 0.036 13.6 0.0 2.3 2 0 0 2 2 2 1 ScpA/B protein HMG_box PF00505.14 KOH00347.1 - 5.5e-13 48.9 1.5 5.5e-13 48.9 1.0 2.6 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOH00347.1 - 6.8e-13 48.7 0.8 6.8e-13 48.7 0.5 1.9 2 0 0 2 2 2 1 HMG-box domain DUF155 PF02582.9 KOH00348.1 - 3.8e-61 206.0 2.3 7e-61 205.1 1.6 1.5 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.1 KOH00348.1 - 0.025 14.7 0.0 0.084 13.0 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Trehalase PF01204.13 KOH00349.1 - 1.5e-192 640.7 0.2 1.8e-192 640.5 0.1 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.6 KOH00349.1 - 2.3e-17 61.9 0.3 4.4e-17 61.0 0.2 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Toxin_ToxA PF11584.3 KOH00349.1 - 0.083 12.7 0.3 0.17 11.7 0.2 1.5 1 0 0 1 1 1 0 Proteinaceous host-selective toxin ToxA Ran_BP1 PF00638.13 KOH00350.1 - 7.3e-57 190.7 2.3 1.1e-56 190.1 1.6 1.3 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.18 KOH00350.1 - 4.2e-05 23.2 1.6 0.00047 19.8 1.1 2.1 1 1 0 1 1 1 1 WH1 domain RCR PF12273.3 KOH00351.1 - 6.6e-40 136.6 0.1 8.5e-40 136.3 0.0 1.3 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red ATG27 PF09451.5 KOH00351.1 - 0.036 13.2 0.2 0.055 12.7 0.1 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 DUF2975 PF11188.3 KOH00351.1 - 0.054 13.2 1.0 0.075 12.7 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) WBP-1 PF11669.3 KOH00351.1 - 0.093 12.8 0.3 0.17 11.9 0.2 1.5 1 1 0 1 1 1 0 WW domain-binding protein 1 DUF3753 PF12575.3 KOH00351.1 - 0.098 12.4 0.7 0.17 11.6 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) Rad51 PF08423.6 KOH00352.1 - 1.4e-28 99.4 0.0 3.9e-28 98.0 0.0 1.6 2 0 0 2 2 2 1 Rad51 AAA_25 PF13481.1 KOH00352.1 - 2.4e-11 43.4 0.0 4.2e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 KOH00352.1 - 7.8e-08 31.7 0.3 1.9e-07 30.4 0.1 1.7 2 0 0 2 2 2 1 KaiC RecA PF00154.16 KOH00352.1 - 5.5e-05 22.3 0.1 9.2e-05 21.6 0.1 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_22 PF13401.1 KOH00352.1 - 0.01 15.9 0.5 0.043 13.9 0.2 2.1 2 1 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 KOH00352.1 - 0.023 14.4 0.4 0.074 12.7 0.0 1.9 2 0 0 2 2 2 0 Archaeal ATPase CobU PF02283.11 KOH00352.1 - 0.031 13.6 0.7 0.12 11.7 0.0 2.2 3 0 0 3 3 3 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Thymidylate_kin PF02223.12 KOH00352.1 - 0.71 9.2 4.4 5.8 6.2 0.0 3.0 3 0 0 3 3 3 0 Thymidylate kinase Maf1 PF09174.5 KOH00353.1 - 3e-49 167.3 4.3 4.5e-49 166.7 3.0 1.2 1 0 0 1 1 1 1 Maf1 regulator Tcp11 PF05794.8 KOH00354.1 - 8.6e-125 416.9 1.9 1.5e-124 416.1 1.3 1.4 1 0 0 1 1 1 1 T-complex protein 11 DUF1088 PF06469.6 KOH00354.1 - 0.057 12.8 0.4 7.9 5.8 0.0 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1088) PRAI PF00697.17 KOH00355.1 - 2.4e-58 196.9 0.0 3e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GalKase_gal_bdg PF10509.4 KOH00356.1 - 1.6e-21 75.3 0.0 3.2e-21 74.3 0.0 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.21 KOH00356.1 - 5.4e-14 52.0 0.1 1.1e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 KOH00356.1 - 1.9e-08 34.3 0.0 4.1e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal Peptidase_C65 PF10275.4 KOH00356.1 - 0.037 13.3 0.2 0.063 12.6 0.1 1.4 1 0 0 1 1 1 0 Peptidase C65 Otubain Ribosomal_L4 PF00573.17 KOH00357.1 - 4.3e-46 156.7 1.1 8.5e-46 155.7 0.8 1.5 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 KOH00357.1 - 2.6e-29 100.9 0.6 3.5e-28 97.3 0.3 2.3 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Methyltransf_31 PF13847.1 KOH00358.1 - 1.2e-12 47.7 0.0 2e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOH00358.1 - 5e-12 45.5 0.0 8.7e-12 44.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 KOH00358.1 - 2.5e-10 40.3 0.0 4.9e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOH00358.1 - 4.7e-10 40.0 0.0 2.1e-09 37.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOH00358.1 - 2e-07 31.3 0.0 5.3e-07 30.0 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOH00358.1 - 6.2e-07 29.2 0.0 1.1e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOH00358.1 - 1.1e-06 28.1 0.0 2.1e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 KOH00358.1 - 1.3e-06 28.7 0.0 3e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.11 KOH00358.1 - 2.1e-06 26.9 0.0 2.7e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_9 PF08003.6 KOH00358.1 - 6.6e-06 25.0 0.1 9.3e-06 24.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.15 KOH00358.1 - 2.1e-05 23.7 0.0 2.9e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.4 KOH00358.1 - 0.00019 20.9 0.0 0.0003 20.3 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.7 KOH00358.1 - 0.00034 21.0 0.0 0.001 19.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 KOH00358.1 - 0.0004 20.4 0.0 0.0019 18.2 0.0 1.8 2 0 0 2 2 2 1 FtsJ-like methyltransferase Met_10 PF02475.11 KOH00358.1 - 0.0039 16.8 0.0 0.0063 16.1 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein PCMT PF01135.14 KOH00358.1 - 0.015 14.8 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.13 KOH00358.1 - 0.018 14.6 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_32 PF13679.1 KOH00358.1 - 0.023 14.3 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 KOH00358.1 - 0.055 12.5 0.0 0.093 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase DOT1 PF08123.8 KOH00358.1 - 0.065 12.5 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 Histone methylation protein DOT1 Cons_hypoth95 PF03602.10 KOH00358.1 - 0.099 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PNPOx_C PF10590.4 KOH00359.1 - 3.5e-21 74.4 2.6 7.7e-21 73.3 1.8 1.6 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxidase PF01243.15 KOH00359.1 - 5.8e-14 51.8 0.0 8.1e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.2 KOH00359.1 - 0.0097 16.1 0.0 0.016 15.5 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PDR_assoc PF08370.6 KOH00360.1 - 0.21 11.0 4.1 1.3 8.6 0.1 3.2 3 0 0 3 3 3 0 Plant PDR ABC transporter associated EmrE PF13536.1 KOH00360.1 - 2.1 8.5 20.6 0.074 13.2 1.7 3.0 4 0 0 4 4 4 0 Multidrug resistance efflux transporter SCO1-SenC PF02630.9 KOH00361.1 - 2.9e-72 241.9 0.0 3.7e-72 241.5 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 KOH00361.1 - 0.00019 21.1 0.0 0.00039 20.0 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.1 KOH00361.1 - 0.069 13.2 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like Chitin_synth_1 PF01644.12 KOH00362.1 - 2.5e-78 261.5 0.5 3.8e-78 260.9 0.4 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 KOH00362.1 - 2.5e-26 91.1 0.0 6e-26 89.9 0.0 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 KOH00362.1 - 2.6e-24 85.5 5.3 1.6e-19 69.7 0.0 3.0 3 0 0 3 3 3 2 Chitin synthase Glyco_tranf_2_3 PF13641.1 KOH00362.1 - 5.5e-11 42.6 0.0 1.6e-09 37.9 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 KOH00362.1 - 1.1e-09 38.3 1.0 1.1e-09 38.3 0.7 2.2 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Ant_C PF05586.6 KOH00362.1 - 0.052 14.0 0.5 0.45 10.9 0.3 2.3 1 1 0 1 1 1 0 Anthrax receptor C-terminus region ATP-synt PF00231.14 KOH00363.1 - 3.4e-67 226.8 6.6 4e-67 226.6 4.6 1.0 1 0 0 1 1 1 1 ATP synthase MecA_N PF05223.6 KOH00363.1 - 0.015 15.3 3.8 0.037 14.0 2.7 1.6 1 0 0 1 1 1 0 NTF2-like N-terminal transpeptidase domain CsrA PF02599.11 KOH00363.1 - 0.066 12.9 0.1 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Global regulator protein family Fig1 PF12351.3 KOH00364.1 - 1.8e-56 190.9 3.5 1.8e-56 190.9 2.4 2.0 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.7 KOH00364.1 - 3.9e-05 23.3 12.3 5.5e-05 22.8 8.5 1.2 1 0 0 1 1 1 1 SUR7/PalI family AMP-binding PF00501.23 KOH00365.1 - 4.3e-64 216.4 0.0 5.2e-64 216.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Acyltransferase PF01553.16 KOH00366.1 - 1e-34 118.8 0.0 1.5e-34 118.2 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase MFS_1 PF07690.11 KOH00367.1 - 7.7e-29 100.4 22.0 7.7e-29 100.4 15.3 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Cpn60_TCP1 PF00118.19 KOH00368.1 - 9.7e-12 44.2 0.2 1.6e-11 43.5 0.1 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family INTS2 PF14750.1 KOH00368.1 - 0.015 12.8 0.0 0.027 11.9 0.0 1.3 1 0 0 1 1 1 0 Integrator complex subunit 2 ADH_zinc_N PF00107.21 KOH00370.1 - 1.5e-28 98.9 0.0 2.4e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KOH00370.1 - 3.4e-12 47.3 0.0 7.9e-12 46.1 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOH00370.1 - 2.6e-10 40.0 0.0 5.7e-10 38.9 0.0 1.6 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Ribosomal_S17 PF00366.15 KOH00372.1 - 3.3e-30 103.9 5.7 5.4e-30 103.2 3.9 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 Myb_DNA-binding PF00249.26 KOH00373.1 - 1.1e-18 66.9 11.4 3.2e-11 43.0 0.7 4.4 4 0 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOH00373.1 - 1.5e-16 60.2 16.4 7.3e-13 48.4 2.0 4.9 4 1 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 KOH00373.1 - 0.014 15.4 0.5 0.014 15.4 0.4 5.5 5 1 0 5 5 5 0 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.4 KOH00373.1 - 0.1 12.8 11.7 0.051 13.7 0.6 4.3 4 0 0 4 4 4 0 Alcohol dehydrogenase transcription factor Myb/SANT-like K_channel_TID PF07941.6 KOH00373.1 - 2.8 8.2 9.3 8.2 6.7 0.1 3.3 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain DUF1752 PF08550.5 KOH00374.1 - 6.6e-06 25.6 0.0 2.2e-05 23.9 0.0 2.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Flavodoxin_1 PF00258.20 KOH00375.1 - 0.0026 17.7 0.1 0.0057 16.6 0.1 1.6 1 1 0 1 1 1 1 Flavodoxin FMN_red PF03358.10 KOH00375.1 - 0.07 12.6 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 NADPH-dependent FMN reductase SGL PF08450.7 KOH00376.1 - 1.5e-49 168.6 0.0 1.8e-49 168.3 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Arylesterase PF01731.15 KOH00376.1 - 0.004 17.1 0.0 2.7 8.0 0.0 2.8 3 0 0 3 3 3 2 Arylesterase Bac_rhodopsin PF01036.13 KOH00377.1 - 6.9e-39 133.4 17.7 9.3e-39 133.0 12.2 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein SR-25 PF10500.4 KOH00377.1 - 0.099 12.0 18.7 0.13 11.7 12.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein BLVR PF06375.6 KOH00377.1 - 0.35 10.6 14.8 0.51 10.1 10.3 1.2 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) GpcrRhopsn4 PF10192.4 KOH00377.1 - 5.1 6.1 16.5 0.91 8.6 3.9 2.2 1 1 1 2 2 2 0 Rhodopsin-like GPCR transmembrane domain DUF4316 PF14195.1 KOH00377.1 - 6.7 6.8 10.0 12 6.1 7.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4316) PRP1_N PF06424.7 KOH00378.1 - 7.8e-30 103.9 5.4 7.8e-30 103.9 3.8 2.2 2 0 0 2 2 2 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.1 KOH00378.1 - 5.2e-18 63.9 0.5 0.028 15.0 0.1 11.3 10 3 3 13 13 12 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOH00378.1 - 1.3e-14 54.2 1.2 0.013 15.7 0.6 8.3 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOH00378.1 - 9.9e-11 41.1 1.7 0.16 11.6 0.0 6.1 5 1 1 6 6 6 3 TPR repeat TPR_16 PF13432.1 KOH00378.1 - 6.1e-10 39.5 0.0 0.11 13.1 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOH00378.1 - 5.5e-07 29.0 4.9 3.2 7.9 0.0 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOH00378.1 - 0.00031 20.6 4.0 42 4.7 0.0 7.2 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOH00378.1 - 0.00071 19.0 0.7 9.6 6.0 0.0 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOH00378.1 - 0.0014 18.5 4.1 3 7.8 0.0 5.5 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOH00378.1 - 0.0055 16.4 4.0 2.9 7.8 0.0 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOH00378.1 - 0.021 15.2 9.9 4.6 7.9 0.0 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOH00378.1 - 0.055 13.2 3.4 11 6.1 0.0 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TMF_TATA_bd PF12325.3 KOH00380.1 - 0.084 12.6 11.3 0.44 10.2 0.1 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding IncA PF04156.9 KOH00380.1 - 0.24 10.9 8.9 0.34 10.4 1.8 2.3 2 0 0 2 2 2 0 IncA protein Prefoldin_2 PF01920.15 KOH00380.1 - 0.24 11.1 15.3 0.064 13.0 2.7 3.1 3 0 0 3 3 3 0 Prefoldin subunit DUF4099 PF13351.1 KOH00380.1 - 0.35 10.7 3.5 0.28 11.1 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4099) UCH PF00443.24 KOH00381.1 - 1.3e-50 171.9 0.2 5.4e-50 169.9 0.0 2.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOH00381.1 - 2.8e-27 95.9 0.3 1.2e-26 93.8 0.0 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 KOH00381.1 - 1.7e-19 69.6 7.6 1.7e-19 69.6 5.3 3.3 4 1 0 4 4 4 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.26 KOH00381.1 - 1.3e-14 53.5 0.0 6.4e-06 25.8 0.0 2.7 2 0 0 2 2 2 2 UBA/TS-N domain PsbQ PF05757.6 KOH00382.1 - 0.11 11.9 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) DUF3317 PF11779.3 KOH00382.1 - 1 8.8 6.3 1.4 8.3 4.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3317) Pkinase PF00069.20 KOH00383.1 - 3e-35 121.6 0.1 8.8e-35 120.0 0.1 1.9 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00383.1 - 6.4e-24 84.4 0.0 1.4e-23 83.3 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOH00383.1 - 0.004 16.9 0.0 0.17 11.5 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family ORC2 PF04084.9 KOH00384.1 - 7.7e-114 379.9 2.9 1e-113 379.4 2.0 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 tRNA-synt_2 PF00152.15 KOH00385.1 - 2.7e-89 299.2 0.2 4.6e-89 298.4 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KOH00385.1 - 1.9e-12 46.8 0.2 4.9e-12 45.5 0.1 1.8 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 KOH00385.1 - 1.8e-07 30.6 0.0 0.0016 17.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FtsJ PF01728.14 KOH00386.1 - 1.6e-64 217.2 0.0 2.1e-64 216.8 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 KOH00386.1 - 0.039 14.5 0.0 0.074 13.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 KOH00386.1 - 0.084 12.5 0.0 0.17 11.5 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain zf-H2C2_2 PF13465.1 KOH00390.1 - 8.5e-06 25.8 2.3 8.5e-06 25.8 1.6 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOH00390.1 - 7.3e-05 22.8 15.5 0.0061 16.8 4.1 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 KOH00390.1 - 0.0004 20.5 19.2 0.019 15.2 2.8 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-RING-like PF08746.6 KOH00390.1 - 0.17 11.9 4.2 0.45 10.5 2.9 1.7 1 0 0 1 1 1 0 RING-like domain zf-met PF12874.2 KOH00390.1 - 1.2 9.4 8.4 0.2 11.8 0.9 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type SRP1_TIP1 PF00660.12 KOH00391.1 - 9.6e-36 121.7 0.8 2.1e-35 120.6 0.5 1.5 1 0 0 1 1 1 1 Seripauperin and TIP1 family Pox_A12 PF04651.8 KOH00391.1 - 0.05 13.7 7.9 0.73 9.9 4.8 2.0 2 0 0 2 2 2 0 Poxvirus A12 protein Macoilin PF09726.4 KOH00391.1 - 0.29 9.3 12.5 0.31 9.2 8.7 1.0 1 0 0 1 1 1 0 Transmembrane protein KAR9 PF08580.5 KOH00391.1 - 1.2 7.2 13.7 1.5 6.9 9.5 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 DUF566 PF04484.7 KOH00391.1 - 2.3 7.6 19.1 2.9 7.3 13.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) Gag_spuma PF03276.9 KOH00391.1 - 2.8 6.1 8.8 3.5 5.8 6.1 1.1 1 0 0 1 1 1 0 Spumavirus gag protein DNA_pol_viral_N PF00242.12 KOH00391.1 - 4.5 6.2 7.4 5 6.0 5.2 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DUF3275 PF11679.3 KOH00391.1 - 7 6.2 6.7 11 5.5 4.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) AA_permease PF00324.16 KOH00392.1 - 7.6e-138 459.8 36.6 9.6e-138 459.4 25.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOH00392.1 - 2.2e-34 118.7 34.9 3e-34 118.2 24.2 1.0 1 0 0 1 1 1 1 Amino acid permease Peptidase_S7 PF00949.16 KOH00392.1 - 0.092 12.1 0.1 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease AA_permease PF00324.16 KOH00393.1 - 4e-123 411.2 38.3 4.6e-123 411.0 26.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOH00393.1 - 4.9e-40 137.3 38.5 5.7e-40 137.1 26.7 1.0 1 0 0 1 1 1 1 Amino acid permease Spore_permease PF03845.8 KOH00393.1 - 0.0029 16.2 17.6 0.0029 16.2 12.2 3.0 3 1 0 3 3 3 2 Spore germination protein ROK PF00480.15 KOH00393.1 - 0.019 14.7 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 ROK family DUF2207 PF09972.4 KOH00393.1 - 2.3 6.6 0.0 2.3 6.6 0.0 3.5 4 0 0 4 4 4 0 Predicted membrane protein (DUF2207) Alg14 PF08660.6 KOH00394.1 - 1.5e-50 171.5 0.8 1.8e-50 171.2 0.1 1.4 2 0 0 2 2 2 1 Oligosaccharide biosynthesis protein Alg14 like HSP20 PF00011.16 KOH00396.1 - 1.4e-25 89.0 2.8 1.9e-25 88.6 1.9 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family SNF2_N PF00176.18 KOH00397.1 - 1.4e-66 224.3 0.0 2.1e-66 223.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOH00397.1 - 2.4e-11 43.3 0.0 7.4e-11 41.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 KOH00397.1 - 1.7e-10 40.1 0.3 6.1e-06 25.2 0.1 2.6 2 0 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.10 KOH00397.1 - 2e-09 37.5 0.2 1.2e-08 34.9 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 KOH00397.1 - 2.3e-07 30.4 0.0 5.1e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2439 PF10382.4 KOH00397.1 - 3.6e-05 23.8 0.3 0.00013 22.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2439) Peptidase_M28 PF04389.12 KOH00398.1 - 3.3e-32 111.6 0.4 5.5e-32 110.9 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.23 KOH00398.1 - 0.00038 20.0 0.0 0.00045 19.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.9 KOH00398.1 - 0.0031 16.3 0.0 0.011 14.5 0.0 1.8 1 1 1 2 2 2 1 M42 glutamyl aminopeptidase DUF2189 PF09955.4 KOH00398.1 - 0.038 13.9 0.0 0.038 13.9 0.0 2.7 4 0 0 4 4 4 0 Predicted integral membrane protein (DUF2189) DUF4451 PF14616.1 KOH00399.1 - 1.2e-08 34.7 1.7 6.2e-08 32.4 1.2 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4451) Recep_L_domain PF01030.19 KOH00401.1 - 5.9e-06 26.2 3.5 0.049 13.6 0.3 3.4 1 1 2 3 3 3 2 Receptor L domain LRR_9 PF14580.1 KOH00401.1 - 0.0036 16.8 0.1 0.0065 16.0 0.0 1.5 1 0 0 1 1 1 1 Leucine-rich repeat DUF4339 PF14237.1 KOH00401.1 - 0.0091 15.5 0.0 0.099 12.2 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4339) LRR_4 PF12799.2 KOH00401.1 - 0.014 14.9 6.9 0.053 13.1 0.4 3.4 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) Macoilin PF09726.4 KOH00401.1 - 7.9 4.6 14.9 11 4.1 10.3 1.2 1 0 0 1 1 1 0 Transmembrane protein PCI PF01399.22 KOH00402.1 - 1.7e-07 31.4 3.7 1.5e-06 28.4 0.2 3.4 2 1 1 3 3 3 1 PCI domain AAA PF00004.24 KOH00403.1 - 2.2e-50 170.2 0.0 1.2e-37 129.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 KOH00403.1 - 2.8e-16 59.2 0.0 1.7e-15 56.7 0.0 2.3 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain CDC48_2 PF02933.12 KOH00403.1 - 2.4e-10 39.8 1.1 6.9e-10 38.4 0.2 2.1 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.1 KOH00403.1 - 9.2e-10 38.7 0.7 0.00036 20.6 0.1 3.3 2 2 0 2 2 2 2 AAA domain AAA_17 PF13207.1 KOH00403.1 - 6.5e-09 36.6 0.0 0.0039 17.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 KOH00403.1 - 3.3e-08 33.1 0.2 0.0041 16.8 0.1 2.5 2 0 0 2 2 2 2 Part of AAA domain AAA_16 PF13191.1 KOH00403.1 - 3.4e-08 33.6 0.0 0.0099 15.8 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.9 KOH00403.1 - 6.7e-07 29.1 0.3 0.0013 18.4 0.0 3.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 KOH00403.1 - 7.3e-07 28.2 0.1 0.027 13.2 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus Mg_chelatase PF01078.16 KOH00403.1 - 1.4e-06 27.6 0.2 0.0017 17.5 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 KOH00403.1 - 3.4e-06 27.3 0.2 0.031 14.5 0.0 3.2 3 1 0 3 3 2 2 AAA domain AAA_33 PF13671.1 KOH00403.1 - 4.4e-06 26.6 0.0 0.028 14.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 KOH00403.1 - 9.3e-06 25.7 0.1 0.083 13.0 0.0 3.5 3 0 0 3 3 3 2 RNA helicase IstB_IS21 PF01695.12 KOH00403.1 - 1.8e-05 24.2 0.2 0.05 13.0 0.0 2.7 3 0 0 3 3 2 2 IstB-like ATP binding protein AAA_14 PF13173.1 KOH00403.1 - 1.9e-05 24.5 0.0 0.093 12.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 KOH00403.1 - 2.3e-05 24.0 2.6 0.021 14.4 0.1 3.5 4 1 1 5 5 3 2 NACHT domain PhoH PF02562.11 KOH00403.1 - 2.3e-05 23.6 0.0 0.03 13.5 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein DUF2075 PF09848.4 KOH00403.1 - 4e-05 22.7 0.0 0.052 12.5 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_2 PF07724.9 KOH00403.1 - 5.2e-05 23.2 0.0 0.002 18.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 KOH00403.1 - 8e-05 21.7 0.6 0.091 11.7 0.1 2.7 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus NB-ARC PF00931.17 KOH00403.1 - 0.00013 20.9 0.0 0.11 11.3 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain Sigma54_activat PF00158.21 KOH00403.1 - 0.00029 20.3 0.0 0.67 9.4 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain ABC_tran PF00005.22 KOH00403.1 - 0.00072 19.8 1.0 0.091 13.0 0.0 2.7 3 0 0 3 3 2 1 ABC transporter AAA_24 PF13479.1 KOH00403.1 - 0.00088 18.9 2.5 0.42 10.1 0.3 2.7 2 1 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 KOH00403.1 - 0.0012 18.6 1.1 1.3 8.6 0.0 3.3 2 1 1 3 3 3 1 Archaeal ATPase Zeta_toxin PF06414.7 KOH00403.1 - 0.0012 17.9 0.1 0.65 9.0 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin KaiC PF06745.8 KOH00403.1 - 0.002 17.3 0.4 0.23 10.5 0.1 2.6 2 0 0 2 2 2 1 KaiC AAA_25 PF13481.1 KOH00403.1 - 0.0022 17.4 6.2 1.6 8.0 0.1 3.9 2 2 2 4 4 4 2 AAA domain UPF0079 PF02367.12 KOH00403.1 - 0.0029 17.2 0.0 2.7 7.6 0.0 3.0 3 0 0 3 3 3 1 Uncharacterised P-loop hydrolase UPF0079 ResIII PF04851.10 KOH00403.1 - 0.003 17.4 0.1 1.1 9.0 0.0 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 KOH00403.1 - 0.0042 16.6 0.0 2.9 7.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 KOH00403.1 - 0.0073 15.7 0.0 0.18 11.1 0.0 2.2 2 0 0 2 2 2 1 AAA-like domain AAA_11 PF13086.1 KOH00403.1 - 0.0087 15.6 0.0 2.3 7.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 KOH00403.1 - 0.0088 16.3 1.0 2.3 8.5 0.1 2.8 2 1 0 2 2 2 1 AAA domain DEAD PF00270.24 KOH00403.1 - 0.0099 15.3 0.2 31 4.0 0.0 3.9 3 1 0 4 4 4 0 DEAD/DEAH box helicase AAA_28 PF13521.1 KOH00403.1 - 0.012 15.6 0.0 2.5 8.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain IPT PF01745.11 KOH00403.1 - 0.014 14.5 0.1 0.11 11.6 0.0 2.1 2 0 0 2 2 2 0 Isopentenyl transferase Zot PF05707.7 KOH00403.1 - 0.021 14.3 0.1 6.9 6.0 0.0 2.9 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) T2SE PF00437.15 KOH00403.1 - 0.021 13.7 0.2 4.2 6.1 0.0 2.7 3 0 0 3 3 2 0 Type II/IV secretion system protein Bac_DnaA PF00308.13 KOH00403.1 - 0.023 14.3 0.1 13 5.3 0.0 3.1 3 0 0 3 3 3 0 Bacterial dnaA protein AAA_3 PF07726.6 KOH00403.1 - 0.023 14.3 0.0 0.2 11.2 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.12 KOH00403.1 - 0.028 13.2 0.0 2.6 6.8 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.1 KOH00403.1 - 0.039 13.9 0.2 16 5.5 0.0 3.1 2 1 0 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.13 KOH00403.1 - 0.18 11.3 0.0 1 8.8 0.0 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Bromodomain PF00439.20 KOH00404.1 - 1.2e-17 63.6 0.3 4.7e-17 61.6 0.2 2.1 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.8 KOH00404.1 - 0.00042 19.9 0.0 0.0012 18.5 0.0 1.8 1 0 0 1 1 1 1 Bromodomain associated UQ_con PF00179.21 KOH00405.1 - 3.1e-43 146.5 0.1 3.4e-43 146.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOH00405.1 - 2.5e-05 24.0 0.0 2.9e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KOH00405.1 - 0.00016 21.5 0.0 0.00022 21.0 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 KOH00405.1 - 0.0024 17.5 0.0 0.0039 16.8 0.0 1.3 1 0 0 1 1 1 1 UEV domain TEA PF01285.13 KOH00406.1 - 3.2e-76 257.2 13.9 3.7e-76 257.0 9.6 1.0 1 0 0 1 1 1 1 TEA/ATTS domain family FTHFS PF01268.14 KOH00407.1 - 9.3e-258 855.7 1.1 1.3e-257 855.3 0.8 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.14 KOH00407.1 - 4.7e-71 237.0 0.9 4.7e-71 237.0 0.6 2.4 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 KOH00407.1 - 2.1e-35 121.2 0.8 6.9e-35 119.6 0.3 2.1 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Mito_carr PF00153.22 KOH00408.1 - 3.4e-70 231.8 7.0 1.8e-24 85.2 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein KH_1 PF00013.24 KOH00409.1 - 5.4e-18 64.3 3.1 6.8e-10 38.4 0.1 3.1 3 0 0 3 3 3 2 KH domain KH_3 PF13014.1 KOH00409.1 - 1.9e-15 56.0 1.6 6.1e-06 25.7 0.0 3.4 3 0 0 3 3 3 2 KH domain KH_2 PF07650.12 KOH00409.1 - 4.3e-05 22.9 0.5 0.09 12.3 0.1 2.5 2 0 0 2 2 2 2 KH domain KH_5 PF13184.1 KOH00409.1 - 0.013 15.3 0.6 1.3 8.8 0.1 2.8 2 1 0 2 2 2 0 NusA-like KH domain KH_4 PF13083.1 KOH00409.1 - 0.049 13.2 0.0 1.3 8.7 0.0 2.5 2 0 0 2 2 2 0 KH domain DUF4421 PF14391.1 KOH00410.1 - 0.041 13.0 0.2 0.043 13.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4421) Spt5-NGN PF03439.8 KOH00410.1 - 0.15 11.8 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Early transcription elongation factor of RNA pol II, NGN section Anoctamin PF04547.7 KOH00411.1 - 2.6e-48 164.8 31.1 1.1e-47 162.7 21.6 1.9 1 1 0 1 1 1 1 Calcium-activated chloride channel Dehydrin PF00257.14 KOH00411.1 - 0.0065 16.8 6.6 0.0065 16.8 4.6 2.3 2 0 0 2 2 2 1 Dehydrin RAMP4 PF06624.7 KOH00411.1 - 0.033 13.7 0.3 0.12 11.9 0.2 1.9 1 0 0 1 1 1 0 Ribosome associated membrane protein RAMP4 SelP_N PF04592.9 KOH00411.1 - 5.6 6.2 12.1 11 5.3 8.4 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Rep_fac_C PF08542.6 KOH00412.1 - 1.1e-19 70.1 1.0 1.2e-18 66.8 0.1 2.5 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 KOH00412.1 - 1e-11 44.7 0.1 3.2e-11 43.1 0.1 1.9 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 KOH00412.1 - 2.8e-06 27.5 0.1 8.5e-06 25.9 0.1 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.8 KOH00412.1 - 0.00023 20.7 0.2 0.00091 18.7 0.0 2.0 2 1 0 2 2 2 1 DNA polymerase III, delta subunit AAA_22 PF13401.1 KOH00412.1 - 0.0041 17.2 1.1 0.027 14.5 0.1 2.7 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.1 KOH00412.1 - 0.0046 16.9 0.0 0.0093 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain NYD-SP12_N PF15015.1 KOH00412.1 - 0.0064 14.7 0.0 0.0093 14.2 0.0 1.1 1 0 0 1 1 1 1 Spermatogenesis-associated, N-terminal Sigma54_activ_2 PF14532.1 KOH00412.1 - 0.0072 16.3 0.0 0.41 10.7 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain RuvB_N PF05496.7 KOH00412.1 - 0.037 13.0 0.0 0.2 10.6 0.0 2.1 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus AAA_10 PF12846.2 KOH00412.1 - 0.085 12.2 0.1 0.24 10.8 0.0 1.7 1 1 0 1 1 1 0 AAA-like domain FtsK_SpoIIIE PF01580.13 KOH00412.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family PCNA_N PF00705.13 KOH00413.1 - 4.2e-52 174.9 1.2 8.7e-52 173.9 0.8 1.5 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 KOH00413.1 - 1.1e-51 174.0 0.0 2.8e-51 172.7 0.0 1.6 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.8 KOH00413.1 - 0.00016 20.9 0.0 0.00021 20.5 0.0 1.3 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.11 KOH00413.1 - 0.00078 18.2 0.5 0.016 14.0 0.4 2.1 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 HMG_box PF00505.14 KOH00414.1 - 1.3e-23 82.9 0.1 2.3e-23 82.2 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOH00414.1 - 9.2e-18 64.3 0.2 9.2e-18 64.3 0.1 1.5 2 0 0 2 2 2 1 HMG-box domain HMG_box_5 PF14887.1 KOH00414.1 - 0.00049 19.8 0.3 0.00049 19.8 0.2 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box 5 CHDNT PF08073.7 KOH00414.1 - 0.064 12.9 0.0 0.099 12.3 0.0 1.3 1 0 0 1 1 1 0 CHDNT (NUC034) domain zf-Tim10_DDP PF02953.10 KOH00415.1 - 2.7e-14 52.2 1.9 3.6e-14 51.7 1.3 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger TTL PF03133.10 KOH00416.1 - 3.6e-92 308.4 4.4 4.8e-92 308.0 3.1 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.12 KOH00416.1 - 6.2e-39 133.3 0.0 1.2e-38 132.3 0.0 1.5 1 0 0 1 1 1 1 Survival protein SurE ATP-grasp_4 PF13535.1 KOH00416.1 - 0.0015 18.2 0.0 0.016 14.9 0.0 2.2 2 1 0 2 2 2 1 ATP-grasp domain Nro1 PF12753.2 KOH00416.1 - 0.005 15.8 1.7 0.01 14.8 1.2 1.4 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 ATPgrasp_YheCD PF14398.1 KOH00416.1 - 0.0052 15.6 0.0 0.37 9.5 0.0 2.6 2 0 0 2 2 2 1 YheC/D like ATP-grasp Sedlin_N PF04628.8 KOH00416.1 - 0.019 14.8 0.3 1.1 9.1 0.0 2.5 2 0 0 2 2 2 0 Sedlin, N-terminal conserved region ATPgrasp_Ter PF15632.1 KOH00416.1 - 0.15 10.7 0.0 1.1 7.8 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon RXT2_N PF08595.6 KOH00417.1 - 1.5e-46 157.8 10.6 1e-45 155.1 1.2 3.1 3 0 0 3 3 3 2 RXT2-like, N-terminal PGC7_Stella PF15549.1 KOH00417.1 - 2.2 8.2 5.6 0.63 10.0 1.5 1.8 2 0 0 2 2 2 0 PGC7/Stella/Dppa3 domain 4HBT_2 PF13279.1 KOH00418.1 - 1.6e-07 31.8 0.0 2.3e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Pkinase PF00069.20 KOH00419.1 - 4.8e-25 88.1 1.0 3e-24 85.5 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00419.1 - 1.7e-12 46.9 0.0 3.5e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT PF02985.17 KOH00419.1 - 2.1e-08 33.5 0.4 2.5 8.3 0.0 5.7 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.1 KOH00419.1 - 0.00022 21.4 0.0 0.0028 17.9 0.0 2.7 2 1 1 3 3 3 1 HEAT repeats Apc4_WD40 PF12894.2 KOH00419.1 - 0.012 15.1 0.0 0.034 13.6 0.0 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.27 KOH00419.1 - 0.034 14.0 3.4 0.57 10.1 0.0 4.0 4 0 0 4 4 4 0 WD domain, G-beta repeat HEAT_EZ PF13513.1 KOH00419.1 - 0.21 12.1 0.2 28 5.3 0.0 3.2 2 1 0 2 2 2 0 HEAT-like repeat ERCC4 PF02732.10 KOH00420.1 - 5e-09 36.0 1.4 5e-09 36.0 1.0 2.1 1 1 1 2 2 2 1 ERCC4 domain Fes1 PF08609.5 KOH00421.1 - 8.6e-29 99.8 0.3 6.9e-28 96.9 0.1 2.3 2 1 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.1 KOH00421.1 - 4.3e-05 23.7 0.0 0.001 19.2 0.0 2.9 2 1 2 4 4 4 1 HEAT repeats IBN_N PF03810.14 KOH00421.1 - 0.002 17.9 0.2 1.4 8.8 0.0 3.8 1 1 3 4 4 4 1 Importin-beta N-terminal domain HEAT_EZ PF13513.1 KOH00421.1 - 0.0056 17.1 0.1 0.12 12.8 0.0 3.0 2 1 1 3 3 3 1 HEAT-like repeat Uso1_p115_head PF04869.9 KOH00421.1 - 0.052 12.3 1.0 1 8.0 0.3 2.5 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, head region UPF0253 PF06786.7 KOH00421.1 - 0.074 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0253) Vps51 PF08700.6 KOH00422.1 - 4.9e-08 32.6 3.0 4.9e-08 32.6 2.1 2.7 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.6 KOH00422.1 - 0.0089 15.8 4.9 0.0089 15.8 3.4 3.4 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Isochorismatase PF00857.15 KOH00422.1 - 0.04 13.8 0.4 0.11 12.4 0.2 1.8 2 0 0 2 2 2 0 Isochorismatase family WD40 PF00400.27 KOH00423.1 - 4.6e-26 89.7 11.9 1.4e-07 31.0 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat LisH PF08513.6 KOH00423.1 - 1.7e-08 33.9 0.1 3.5e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 LisH RAB3GAP2_N PF14655.1 KOH00423.1 - 0.00061 18.9 0.0 0.00088 18.3 0.0 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Nup160 PF11715.3 KOH00423.1 - 0.00083 17.6 0.7 0.029 12.5 0.0 2.9 3 1 0 3 3 3 1 Nucleoporin Nup120/160 DUF4099 PF13351.1 KOH00423.1 - 0.08 12.8 0.0 1.5 8.7 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4099) Mito_carr PF00153.22 KOH00424.1 - 2.1e-62 206.8 1.6 4.9e-22 77.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Vac_ImportDeg PF09783.4 KOH00425.1 - 1.7e-69 232.8 3.5 4.4e-69 231.5 2.4 1.6 1 1 0 1 1 1 1 Vacuolar import and degradation protein Pho88 PF10032.4 KOH00427.1 - 4.4e-82 273.9 0.8 4.9e-82 273.8 0.6 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) CENP-L PF13092.1 KOH00428.1 - 4e-05 23.4 0.0 6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 MATH PF00917.21 KOH00428.1 - 0.028 14.6 0.3 0.057 13.6 0.2 1.5 1 1 0 1 1 1 0 MATH domain EF-hand_1 PF00036.27 KOH00430.1 - 2.3e-30 101.5 4.3 1.7e-08 33.1 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOH00430.1 - 9.6e-27 92.9 0.8 2.2e-13 50.1 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOH00430.1 - 4.8e-26 88.2 3.1 6.3e-08 31.8 0.0 4.3 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOH00430.1 - 9.7e-18 63.5 5.6 1.1e-06 28.1 0.0 4.2 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOH00430.1 - 3e-17 61.0 3.7 1.9e-07 30.1 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 KOH00430.1 - 2.5e-12 46.5 0.0 1.9e-08 34.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.4 KOH00430.1 - 1.9e-06 27.9 0.2 0.00061 19.8 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.8 KOH00430.1 - 3.4e-06 26.5 0.0 0.018 14.6 0.0 2.7 2 1 0 3 3 3 2 Uncharacterised protein family (UPF0154) Caleosin PF05042.8 KOH00430.1 - 0.00069 19.2 0.0 0.35 10.3 0.0 2.2 2 0 0 2 2 2 2 Caleosin related protein EF-hand_4 PF12763.2 KOH00430.1 - 0.0034 17.0 0.4 0.009 15.7 0.1 1.7 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand DUF853 PF05872.7 KOH00430.1 - 0.0035 15.7 0.3 0.096 11.0 0.0 2.0 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF853) TerB PF05099.8 KOH00430.1 - 0.01 15.5 0.1 0.51 10.0 0.0 2.2 2 1 0 2 2 2 0 Tellurite resistance protein TerB p25-alpha PF05517.7 KOH00430.1 - 0.038 14.2 0.0 0.95 9.7 0.0 2.1 1 1 1 2 2 2 0 p25-alpha PepSY_2 PF13670.1 KOH00430.1 - 0.065 13.1 0.0 9 6.2 0.0 2.2 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Glycos_transf_1 PF00534.15 KOH00431.1 - 3e-13 49.5 0.0 5.4e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 KOH00431.1 - 3.5e-13 49.8 0.0 1.3e-12 48.0 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 KOH00431.1 - 5.9e-05 23.2 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 KOH00431.1 - 0.00046 20.3 0.0 0.00065 19.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain NUDIX PF00293.23 KOH00432.1 - 3.6e-17 62.2 0.0 2.1e-16 59.7 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain TPR_1 PF00515.23 KOH00433.1 - 2.3e-48 159.8 21.1 1.9e-07 30.4 0.0 11.0 10 1 0 10 10 10 10 Tetratricopeptide repeat TPR_11 PF13414.1 KOH00433.1 - 5.3e-44 147.7 23.7 4.6e-10 39.0 0.5 6.7 2 2 4 7 7 7 7 TPR repeat TPR_2 PF07719.12 KOH00433.1 - 4.8e-42 138.5 21.9 9.9e-05 21.9 0.0 10.7 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_12 PF13424.1 KOH00433.1 - 4.9e-30 103.3 28.6 8.1e-08 32.0 0.3 7.7 2 2 6 8 8 8 8 Tetratricopeptide repeat TPR_17 PF13431.1 KOH00433.1 - 4.7e-27 91.8 29.3 0.00054 19.9 0.1 11.0 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_8 PF13181.1 KOH00433.1 - 6e-25 85.1 15.5 0.034 13.9 0.0 10.6 9 1 1 10 10 10 8 Tetratricopeptide repeat TPR_7 PF13176.1 KOH00433.1 - 4.6e-21 72.9 16.4 0.00065 19.3 0.1 10.0 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOH00433.1 - 2.1e-15 56.9 14.6 4.2e-05 24.0 0.9 8.5 6 2 2 8 8 7 6 Tetratricopeptide repeat TPR_14 PF13428.1 KOH00433.1 - 1.1e-13 50.4 68.2 0.0011 19.4 0.3 12.3 3 3 8 11 11 10 7 Tetratricopeptide repeat TPR_9 PF13371.1 KOH00433.1 - 5.8e-08 32.4 6.5 7.3e-05 22.5 0.0 7.7 4 3 4 8 8 7 5 Tetratricopeptide repeat TPR_6 PF13174.1 KOH00433.1 - 0.0017 18.7 52.9 0.73 10.4 0.0 12.1 11 1 0 11 11 10 4 Tetratricopeptide repeat DUF4131 PF13567.1 KOH00434.1 - 0.23 10.8 2.4 0.35 10.2 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) SNF2_N PF00176.18 KOH00435.1 - 1.6e-75 253.6 0.3 2.5e-75 253.0 0.2 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOH00435.1 - 7.8e-11 41.6 0.0 2.1e-10 40.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOH00435.1 - 2.3e-09 36.9 0.0 4.7e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4 PF00097.20 KOH00435.1 - 5.9e-08 32.2 11.3 5.9e-08 32.2 7.8 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOH00435.1 - 5.9e-05 22.8 9.1 5.9e-05 22.8 6.3 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOH00435.1 - 0.00023 21.1 9.4 0.00023 21.1 6.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KOH00435.1 - 0.003 17.4 9.7 0.003 17.4 6.7 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Zn_Tnp_IS91 PF14319.1 KOH00435.1 - 0.22 11.0 10.8 0.086 12.3 0.6 2.5 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-RING_6 PF14835.1 KOH00435.1 - 0.29 10.9 3.3 0.93 9.3 2.3 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein AMP-binding PF00501.23 KOH00436.1 - 9.2e-72 241.7 0.0 1.2e-71 241.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.7 KOH00436.1 - 1.9e-68 230.1 0.0 3.3e-68 229.3 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.20 KOH00436.1 - 2.5e-16 59.6 0.0 5.9e-16 58.4 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.16 KOH00436.1 - 7.6e-11 41.8 0.0 1.4e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.1 KOH00436.1 - 1.5e-07 32.2 0.0 6.7e-07 30.1 0.0 2.2 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.14 KOH00436.1 - 2.1e-05 23.3 0.0 6.7e-05 21.7 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Condensation PF00668.15 KOH00436.1 - 0.041 12.7 0.7 0.066 12.0 0.0 1.7 2 0 0 2 2 2 0 Condensation domain Transketolase_N PF00456.16 KOH00437.1 - 8.2e-151 501.4 0.0 1.1e-150 501.0 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 KOH00437.1 - 1.8e-48 164.4 0.0 2.9e-48 163.7 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 KOH00437.1 - 6.8e-13 48.6 0.0 1.4e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.1 KOH00437.1 - 8.7e-05 21.5 0.1 0.0019 17.2 0.1 2.3 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.15 KOH00437.1 - 0.00015 20.6 0.0 0.00047 18.9 0.0 1.8 2 0 0 2 2 2 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.16 KOH00437.1 - 0.00027 20.5 0.1 0.0029 17.1 0.1 2.4 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain XFP_C PF09363.5 KOH00437.1 - 0.059 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 XFP C-terminal domain GTP_EFTU PF00009.22 KOH00438.1 - 5.9e-57 192.1 0.1 8.9e-57 191.5 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 KOH00438.1 - 1.5e-35 121.2 0.0 4.8e-35 119.6 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 KOH00438.1 - 6.4e-17 61.4 2.2 6.4e-17 61.4 1.5 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 KOH00438.1 - 2.7e-05 23.6 0.6 2.7e-05 23.6 0.4 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 KOH00438.1 - 0.0012 18.8 0.3 0.0037 17.2 0.2 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase RRM_1 PF00076.17 KOH00439.1 - 3e-11 42.7 0.0 1.3e-07 31.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOH00439.1 - 8.1e-08 32.1 0.0 0.014 15.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOH00439.1 - 3.4e-07 30.0 0.1 0.034 13.9 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF240 PF03086.9 KOH00439.1 - 0.16 11.5 2.9 0.1 12.2 0.7 1.7 2 0 0 2 2 2 0 MG032/MG096/MG288 family 2 CHD5 PF04420.9 KOH00439.1 - 2 8.0 5.3 0.87 9.2 1.8 1.8 1 1 1 2 2 2 0 CHD5-like protein CABS1 PF15367.1 KOH00440.1 - 0.049 12.5 0.6 0.065 12.0 0.4 1.1 1 0 0 1 1 1 0 Calcium-binding and spermatid-specific protein 1 tRNA-synt_2b PF00587.20 KOH00441.1 - 3.7e-73 244.7 0.1 6.3e-73 244.0 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KOH00441.1 - 1.8e-20 72.6 1.7 2.3e-20 72.3 0.1 2.1 2 0 0 2 2 2 1 Anticodon binding domain Ribosomal_L31 PF01197.13 KOH00442.1 - 0.027 14.4 0.0 0.05 13.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L31 SPOUT_MTase PF02590.12 KOH00442.1 - 0.039 13.6 0.2 0.056 13.1 0.1 1.3 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase Ribosomal_60s PF00428.14 KOH00442.1 - 0.04 14.3 1.1 0.065 13.6 0.8 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein TGF_beta_GS PF08515.7 KOH00442.1 - 0.094 12.0 0.3 0.21 10.9 0.2 1.6 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif Tau95 PF09734.4 KOH00443.1 - 3.1e-65 220.5 2.2 4.5e-65 220.0 1.6 1.2 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit PP2C PF00481.16 KOH00444.1 - 4.3e-74 249.1 0.0 4.2e-70 236.0 0.0 2.1 1 1 1 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 KOH00444.1 - 4.2e-06 26.3 0.1 8.9e-05 21.9 0.1 2.6 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOH00444.1 - 0.00025 20.8 0.0 0.17 11.5 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) Glyco_transf_20 PF00982.16 KOH00445.1 - 2.1e-202 672.8 0.1 2.4e-202 672.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glycos_transf_1 PF00534.15 KOH00445.1 - 0.00024 20.5 2.3 0.1 12.0 0.1 3.4 3 1 0 3 3 3 2 Glycosyl transferases group 1 ATP-synt_ab PF00006.20 KOH00446.1 - 3.8e-61 206.3 0.0 5.5e-61 205.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 KOH00446.1 - 4.2e-16 59.4 0.5 8.8e-16 58.3 0.4 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 KOH00446.1 - 1.1e-14 54.3 1.2 2.5e-14 53.2 0.8 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 KOH00446.1 - 0.00012 21.8 0.5 0.00035 20.4 0.3 1.8 1 0 0 1 1 1 1 HAS barrel domain Atg14 PF10186.4 KOH00447.1 - 6.7e-56 189.4 6.5 7.9e-56 189.2 4.5 1.1 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 Fib_alpha PF08702.5 KOH00447.1 - 0.00016 21.8 2.4 0.00016 21.8 1.6 2.3 3 0 0 3 3 3 1 Fibrinogen alpha/beta chain family AAA_13 PF13166.1 KOH00447.1 - 0.012 14.1 5.1 0.015 13.8 3.6 1.1 1 0 0 1 1 1 0 AAA domain Laminin_II PF06009.7 KOH00447.1 - 0.032 13.9 5.9 0.038 13.7 3.4 1.6 1 1 0 1 1 1 0 Laminin Domain II TSA PF03249.8 KOH00447.1 - 0.033 12.7 0.3 0.041 12.4 0.2 1.4 1 0 0 1 1 1 0 Type specific antigen ATG16 PF08614.6 KOH00447.1 - 0.1 12.4 7.7 0.15 11.8 5.3 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) TetR_C_4 PF08359.6 KOH00447.1 - 0.1 12.5 1.3 0.22 11.4 0.9 1.5 1 0 0 1 1 1 0 YsiA-like protein, C-terminal region IncA PF04156.9 KOH00447.1 - 0.2 11.2 4.4 0.33 10.5 3.0 1.4 1 0 0 1 1 1 0 IncA protein Mnd1 PF03962.10 KOH00447.1 - 0.62 9.7 7.1 0.38 10.4 2.5 2.0 2 0 0 2 2 2 0 Mnd1 family PH PF00169.24 KOH00448.1 - 6.9e-08 32.6 6.9 4.5e-05 23.5 0.9 2.6 2 1 0 2 2 2 2 PH domain PH_11 PF15413.1 KOH00448.1 - 0.0033 17.6 7.0 0.063 13.5 0.1 3.0 2 2 1 3 3 3 2 Pleckstrin homology domain Levi_coat PF01819.12 KOH00449.1 - 0.52 9.8 5.8 0.61 9.6 0.2 2.4 2 0 0 2 2 2 0 Levivirus coat protein DUF1712 PF08217.6 KOH00450.1 - 1.8e-202 673.8 19.5 2.1e-202 673.6 13.5 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) AA_permease PF00324.16 KOH00451.1 - 6.2e-136 453.5 24.9 7e-136 453.3 17.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOH00451.1 - 3.1e-26 91.9 27.8 4e-26 91.5 19.3 1.1 1 0 0 1 1 1 1 Amino acid permease DUF1772 PF08592.6 KOH00451.1 - 2 8.1 16.0 0.2 11.3 0.2 4.2 4 1 0 4 4 4 0 Domain of unknown function (DUF1772) PRMT5 PF05185.11 KOH00452.1 - 1.4e-154 515.3 1.3 1.8e-154 515.0 0.9 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase CKS PF01111.14 KOH00453.1 - 7.5e-36 121.8 0.1 1.2e-35 121.1 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit PI3_PI4_kinase PF00454.22 KOH00454.1 - 3.4e-54 183.7 0.3 1.1e-53 182.0 0.2 2.0 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.8 KOH00454.1 - 5.4e-34 116.3 0.6 5.4e-34 116.3 0.4 3.7 5 0 0 5 5 5 1 UME (NUC010) domain FATC PF02260.15 KOH00454.1 - 8.7e-15 53.8 0.1 1.9e-14 52.8 0.1 1.6 1 0 0 1 1 1 1 FATC domain TPR_19 PF14559.1 KOH00454.1 - 0.11 12.8 0.0 0.77 10.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF336 PF03928.9 KOH00455.1 - 2.6e-29 101.6 0.0 3.1e-29 101.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF336) zf-C3HC4_2 PF13923.1 KOH00456.1 - 0.16 11.9 2.3 0.33 11.0 1.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Peptidase_S10 PF00450.17 KOH00457.1 - 1.6e-129 432.7 0.2 1.9e-129 432.4 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 KOH00457.1 - 9e-05 22.4 0.0 0.00035 20.5 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family RasGAP PF00616.14 KOH00458.1 - 9.8e-36 123.2 0.3 3.8e-35 121.3 0.2 2.2 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase DUF2717 PF10911.3 KOH00458.1 - 0.045 13.2 0.0 2.6 7.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2717) DUF3321 PF11968.3 KOH00459.1 - 2e-73 246.6 0.0 2.9e-73 246.1 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase (DUF3321) Methyltransf_23 PF13489.1 KOH00459.1 - 1.5e-07 31.2 0.0 4.8e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOH00459.1 - 0.00048 19.7 0.1 0.0012 18.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOH00459.1 - 0.00065 20.1 0.0 0.032 14.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOH00459.1 - 0.00073 19.9 0.1 0.0021 18.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOH00459.1 - 0.0017 18.9 0.0 0.0034 17.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.13 KOH00459.1 - 0.024 13.9 0.1 0.08 12.2 0.0 1.8 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain NodS PF05401.6 KOH00459.1 - 0.059 12.7 0.0 0.16 11.3 0.0 1.7 2 0 0 2 2 2 0 Nodulation protein S (NodS) RD3 PF14473.1 KOH00459.1 - 0.13 11.7 0.2 0.22 11.0 0.1 1.4 1 0 0 1 1 1 0 RD3 protein DEAD PF00270.24 KOH00460.1 - 7.9e-39 132.8 0.2 1.6e-38 131.8 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOH00460.1 - 1.8e-26 91.8 0.2 9.5e-25 86.2 0.1 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Na_trans_assoc PF06512.8 KOH00460.1 - 3.4 7.5 23.4 0.19 11.6 10.1 2.8 3 0 0 3 3 3 0 Sodium ion transport-associated Astro_capsid PF03115.9 KOH00460.1 - 5.6 5.0 10.1 14 3.8 7.0 1.6 1 0 0 1 1 1 0 Astrovirus capsid protein precursor eRF1_2 PF03464.10 KOH00461.1 - 1.1e-44 152.0 0.1 1.8e-44 151.2 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 KOH00461.1 - 6.2e-38 129.5 0.2 1.4e-37 128.4 0.2 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.10 KOH00461.1 - 7.4e-28 96.7 0.1 1.3e-27 95.9 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 1 ADH_N PF08240.7 KOH00462.1 - 2e-30 104.7 1.1 2e-30 104.7 0.7 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOH00462.1 - 1.5e-29 102.1 0.5 2.1e-29 101.6 0.3 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KOH00462.1 - 1.1e-05 26.3 0.0 2.5e-05 25.1 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF539 PF04400.8 KOH00462.1 - 0.09 12.2 0.2 0.09 12.2 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF539) Ribosomal_S9 PF00380.14 KOH00463.1 - 7.7e-38 129.4 0.2 1.2e-37 128.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DUF4340 PF14238.1 KOH00463.1 - 0.086 12.5 0.2 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4340) PQ-loop PF04193.9 KOH00464.1 - 4.3e-42 141.4 10.9 1.8e-23 81.8 1.6 3.0 4 0 0 4 4 4 2 PQ loop repeat Steroid_dh PF02544.11 KOH00464.1 - 0.016 14.9 0.8 0.054 13.2 0.1 2.1 2 0 0 2 2 2 0 3-oxo-5-alpha-steroid 4-dehydrogenase YbhQ PF11076.3 KOH00464.1 - 0.047 13.2 0.2 0.12 12.0 0.1 1.6 1 0 0 1 1 1 0 Putative inner membrane protein YbhQ DUF3278 PF11683.3 KOH00464.1 - 0.057 13.4 1.6 0.84 9.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) MtN3_slv PF03083.11 KOH00464.1 - 3.3 7.6 9.8 2.6 7.9 0.6 3.2 2 1 1 3 3 3 0 Sugar efflux transporter for intercellular exchange DUF4191 PF13829.1 KOH00465.1 - 0.00071 18.7 1.9 0.00071 18.7 1.3 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4191) Aldo_ket_red PF00248.16 KOH00466.1 - 2e-43 148.2 0.0 2.4e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Fungal_trans PF04082.13 KOH00467.1 - 2.6e-26 92.0 4.3 7.9e-26 90.4 3.0 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOH00467.1 - 8.9e-09 35.1 11.2 1.6e-08 34.2 7.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CRS1_YhbY PF01985.16 KOH00467.1 - 0.073 13.0 0.3 0.22 11.5 0.2 1.7 1 0 0 1 1 1 0 CRS1 / YhbY (CRM) domain CobT PF06213.7 KOH00467.1 - 0.23 10.5 23.8 0.51 9.4 16.5 1.6 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.9 KOH00467.1 - 0.24 9.3 21.0 0.47 8.4 14.6 1.5 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.5 KOH00467.1 - 2.7 6.9 36.9 0.0058 15.7 18.1 1.9 2 0 0 2 2 2 0 BUD22 Astro_capsid PF03115.9 KOH00467.1 - 3.9 5.5 7.5 5.8 5.0 5.2 1.2 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Suc_Fer-like PF06999.7 KOH00468.1 - 9.9e-59 199.1 0.0 1.2e-58 198.8 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Tropomodulin PF03250.9 KOH00469.1 - 0.28 10.6 10.5 0.032 13.7 3.1 2.2 1 1 1 2 2 2 0 Tropomodulin TM231 PF10149.4 KOH00469.1 - 0.63 8.9 12.7 0.55 9.1 0.4 2.4 2 1 1 3 3 3 0 Transmembrane protein 231 RibD_C PF01872.12 KOH00470.1 - 1.3e-39 135.9 0.0 1.5e-39 135.7 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain RNA_pol_Rpb5_N PF03871.9 KOH00471.1 - 2.8e-33 114.1 0.4 4.8e-33 113.4 0.3 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain RNA_pol_Rpb5_C PF01191.14 KOH00471.1 - 1.6e-32 110.9 0.4 2.9e-32 110.0 0.3 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain Mrr_cat PF04471.7 KOH00471.1 - 0.02 14.7 0.0 0.081 12.7 0.0 1.9 2 0 0 2 2 2 0 Restriction endonuclease TPR_11 PF13414.1 KOH00472.1 - 3.7e-15 55.3 3.5 7.3e-13 47.9 1.3 2.6 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOH00472.1 - 1e-09 37.5 6.0 4.3e-06 26.0 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOH00472.1 - 7.1e-09 34.9 4.6 0.0052 16.5 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOH00472.1 - 0.00012 22.6 0.0 0.44 11.2 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 KOH00472.1 - 0.00013 22.0 4.2 0.00026 21.0 2.4 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 KOH00472.1 - 0.00084 18.9 0.7 0.64 9.9 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOH00472.1 - 0.0042 16.9 1.2 0.64 9.9 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat LRR_6 PF13516.1 KOH00474.1 - 3.7e-05 23.3 5.0 0.16 12.1 0.0 5.7 6 0 0 6 6 6 2 Leucine Rich repeat LRR_4 PF12799.2 KOH00474.1 - 0.00017 21.1 11.1 0.25 10.9 1.8 5.0 3 1 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOH00474.1 - 0.022 14.5 10.0 0.11 12.2 0.5 4.4 3 2 1 4 4 4 0 Leucine rich repeat LRR_7 PF13504.1 KOH00474.1 - 2.8 8.5 6.3 67 4.3 0.3 4.4 4 1 0 4 4 4 0 Leucine rich repeat adh_short PF00106.20 KOH00475.1 - 1.1e-21 77.5 0.0 1.5e-21 77.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOH00475.1 - 3.6e-11 43.2 0.0 6e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOH00475.1 - 5.3e-07 29.4 0.0 8.7e-07 28.7 0.0 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 KOH00475.1 - 4.6e-05 23.4 0.0 7.2e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 KOH00475.1 - 0.0012 17.8 0.2 0.0019 17.1 0.1 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3HCDH_N PF02737.13 KOH00475.1 - 0.055 13.1 0.2 0.1 12.2 0.1 1.5 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 KOH00475.1 - 0.079 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family T_Ag_DNA_bind PF02217.11 KOH00475.1 - 0.099 13.0 0.6 0.38 11.1 0.0 2.1 2 0 0 2 2 2 0 Origin of replication binding protein Pkinase PF00069.20 KOH00476.1 - 1.4e-71 240.7 0.0 1.6e-71 240.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00476.1 - 2e-33 115.5 0.0 2.4e-33 115.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH00476.1 - 4.3e-06 25.8 0.0 6.7e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOH00476.1 - 0.0027 17.4 0.1 0.048 13.3 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 KOH00476.1 - 0.064 12.3 0.1 0.27 10.2 0.1 1.9 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 KOH00476.1 - 0.086 11.6 0.1 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Gly_transf_sug PF04488.10 KOH00477.1 - 1.6e-20 73.4 0.2 8.6e-20 71.0 0.0 2.2 2 1 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 KOH00477.1 - 0.02 13.4 4.7 0.19 10.1 0.3 2.3 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain DUF2401 PF10287.4 KOH00478.1 - 1.4e-96 322.5 2.0 1.4e-96 322.5 1.4 1.9 3 0 0 3 3 3 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.4 KOH00478.1 - 2.2e-29 101.3 0.1 2.2e-29 101.3 0.1 2.6 3 0 0 3 3 3 1 Glycine-rich protein domain (DUF2403) CamS PF07537.6 KOH00478.1 - 0.15 11.1 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 CamS sex pheromone cAM373 precursor DUF1573 PF07610.6 KOH00478.1 - 0.25 10.9 3.5 0.53 9.8 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1573) MAP65_ASE1 PF03999.7 KOH00478.1 - 0.56 8.7 2.0 0.72 8.3 1.4 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Macoilin PF09726.4 KOH00478.1 - 2.8 6.0 10.4 3.5 5.7 7.2 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF515 PF04415.7 KOH00478.1 - 9.2 4.3 9.1 16 3.6 6.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF515) RAMP4 PF06624.7 KOH00479.1 - 9.5e-05 21.8 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 DUF2207 PF09972.4 KOH00479.1 - 0.024 13.2 0.1 0.024 13.2 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Exo5 PF09810.4 KOH00480.1 - 1.7e-29 103.0 0.5 6.3e-29 101.2 0.3 1.9 1 1 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.2 KOH00480.1 - 2.2e-07 30.5 0.0 1.4e-06 27.8 0.0 2.3 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Arf PF00025.16 KOH00481.1 - 1e-76 256.0 0.1 1.2e-76 255.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 KOH00481.1 - 2.2e-11 43.3 0.0 2.6e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 KOH00481.1 - 3.7e-11 42.6 0.0 4.3e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 KOH00481.1 - 2.5e-10 39.9 0.0 3.1e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.15 KOH00481.1 - 3.5e-10 39.1 0.5 1.8e-06 26.9 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Miro PF08477.8 KOH00481.1 - 2.2e-09 37.8 0.0 3e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 KOH00481.1 - 1.1e-05 24.9 0.2 0.00018 21.0 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOH00481.1 - 0.00049 20.0 0.0 0.00073 19.4 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 KOH00481.1 - 0.0013 19.0 0.3 0.0046 17.2 0.2 1.7 1 1 0 1 1 1 1 ABC transporter ArgK PF03308.11 KOH00481.1 - 0.0027 16.5 0.9 0.25 10.1 0.2 2.8 2 1 0 2 2 2 1 ArgK protein cobW PF02492.14 KOH00481.1 - 0.082 12.3 0.6 4.5 6.6 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PDH PF02153.12 KOH00483.1 - 2.3e-10 39.8 0.0 3.6e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase NAD_binding_2 PF03446.10 KOH00483.1 - 1.3e-05 25.1 0.0 2.4e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 KOH00483.1 - 4.5e-05 23.8 0.0 8.8e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 KOH00483.1 - 7.9e-05 21.8 0.0 0.00022 20.4 0.0 1.7 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.11 KOH00483.1 - 0.00011 21.6 0.0 0.00021 20.7 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.13 KOH00483.1 - 0.004 16.8 0.0 0.014 15.0 0.0 1.8 1 1 1 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.7 KOH00483.1 - 0.022 14.1 0.0 0.043 13.1 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain UDPG_MGDP_dh_N PF03721.9 KOH00483.1 - 0.063 12.6 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Rpp20 PF12328.3 KOH00484.1 - 1.1e-29 102.9 5.4 9.9e-28 96.6 3.7 2.2 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.16 KOH00484.1 - 1.7e-15 56.3 0.2 2.7e-15 55.7 0.2 1.3 1 0 0 1 1 1 1 Alba vWA-TerF-like PF10138.4 KOH00484.1 - 0.015 15.1 0.3 0.085 12.6 0.1 1.9 1 1 1 2 2 2 0 vWA found in TerF C terminus AA_kinase PF00696.23 KOH00484.1 - 0.037 13.5 0.1 0.042 13.3 0.1 1.1 1 0 0 1 1 1 0 Amino acid kinase family Pex24p PF06398.6 KOH00485.1 - 1.2e-58 198.6 15.7 1.4e-58 198.4 10.9 1.0 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Cleaved_Adhesin PF07675.6 KOH00485.1 - 0.11 12.0 2.2 0.19 11.2 1.5 1.3 1 0 0 1 1 1 0 Cleaved Adhesin Domain HSP70 PF00012.15 KOH00486.1 - 2.2e-185 617.0 0.0 3e-185 616.6 0.0 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOH00486.1 - 1.1e-09 37.3 0.0 3.9e-09 35.5 0.0 1.7 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.1 KOH00486.1 - 4.7e-05 23.2 1.1 0.0051 16.6 0.1 3.8 2 2 0 2 2 2 1 Cell division protein FtsA AHS1 PF02682.11 KOH00486.1 - 0.006 16.0 0.2 0.035 13.5 0.0 2.1 2 0 0 2 2 2 1 Allophanate hydrolase subunit 1 NPL4 PF05021.10 KOH00487.1 - 8e-126 419.3 0.0 1.2e-125 418.7 0.0 1.3 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.10 KOH00487.1 - 2.6e-73 244.5 3.3 3.9e-73 243.9 2.3 1.2 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.3 KOH00487.1 - 4.1e-05 23.7 0.0 0.00012 22.2 0.0 1.9 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 Sec66 PF09802.4 KOH00488.1 - 2.7e-76 255.1 3.9 3.1e-76 255.0 2.7 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 TMEM154 PF15102.1 KOH00488.1 - 0.013 15.2 0.1 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Aha1_N PF09229.6 KOH00488.1 - 0.079 12.7 0.9 0.14 12.0 0.1 1.8 2 0 0 2 2 2 0 Activator of Hsp90 ATPase, N-terminal GYF PF02213.11 KOH00489.1 - 2.1e-18 65.6 0.6 5.6e-18 64.2 0.1 2.0 2 0 0 2 2 2 1 GYF domain UMP1 PF05348.6 KOH00490.1 - 3.3e-44 150.0 0.1 3.8e-44 149.7 0.1 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 WD40 PF00400.27 KOH00491.1 - 3e-27 93.4 13.7 2e-09 36.9 0.0 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat Nup160 PF11715.3 KOH00491.1 - 3.2e-06 25.5 0.1 0.013 13.6 0.0 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 KOH00491.1 - 6.7e-06 24.6 0.0 0.017 13.4 0.0 2.6 2 1 1 3 3 3 2 Cytochrome D1 heme domain eIF2A PF08662.6 KOH00491.1 - 0.0041 16.8 0.1 1.7 8.3 0.0 3.6 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A DPPIV_N PF00930.16 KOH00491.1 - 0.14 10.7 0.0 1.4 7.4 0.0 2.3 1 1 0 1 1 1 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pantoate_transf PF02548.10 KOH00492.1 - 4.8e-98 327.4 0.0 5.6e-98 327.2 0.0 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.1 KOH00492.1 - 4.4e-05 22.8 0.0 8.9e-05 21.8 0.0 1.6 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Abhydrolase_1 PF00561.15 KOH00493.1 - 8.7e-38 130.1 0.0 1.4e-37 129.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOH00493.1 - 2.2e-14 53.8 0.0 3.3e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOH00493.1 - 2.7e-07 30.4 0.0 1.3e-06 28.2 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOH00493.1 - 1.8e-05 24.1 0.0 0.0015 17.7 0.0 2.3 2 0 0 2 2 2 1 Prolyl oligopeptidase family DUF2669 PF10876.3 KOH00493.1 - 0.084 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2669) ORC3_N PF07034.6 KOH00493.1 - 0.13 11.1 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus Ser_hydrolase PF06821.8 KOH00493.1 - 0.17 11.5 0.0 0.44 10.1 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase Dynamin_N PF00350.18 KOH00494.1 - 2.2e-14 53.6 1.2 7.6e-14 51.8 0.1 2.4 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.18 KOH00494.1 - 2.3e-08 34.0 0.1 2e-07 30.9 0.1 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOH00494.1 - 9.4e-08 31.7 0.7 6.4e-05 22.4 1.0 2.7 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain PduV-EutP PF10662.4 KOH00494.1 - 0.017 14.6 0.2 8.9 5.7 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation MFS_1 PF07690.11 KOH00495.1 - 2.6e-49 167.8 40.1 1.3e-44 152.4 12.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 KOH00495.1 - 9.7e-20 70.5 28.1 2.9e-18 65.6 1.7 2.4 3 0 0 3 3 3 2 Sugar (and other) transporter Ribosomal_S6e PF01092.14 KOH00496.1 - 3.1e-25 88.2 0.2 6.4e-25 87.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e Cadherin_C PF01049.12 KOH00496.1 - 0.054 13.5 0.2 0.081 12.9 0.1 1.2 1 0 0 1 1 1 0 Cadherin cytoplasmic region SRF-TF PF00319.13 KOH00497.1 - 7.3e-25 85.9 0.0 7.3e-25 85.9 0.0 1.8 2 0 0 2 2 2 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Ceramidase PF05875.7 KOH00498.1 - 1.3e-95 319.5 14.0 1.5e-95 319.3 9.7 1.0 1 0 0 1 1 1 1 Ceramidase Leader_Trp PF08255.6 KOH00498.1 - 0.16 11.7 3.2 0.52 10.0 2.2 1.9 1 0 0 1 1 1 0 Trp-operon Leader Peptide MBA1 PF07961.6 KOH00500.1 - 6.5e-108 358.9 1.4 8.8e-108 358.5 1.0 1.2 1 0 0 1 1 1 1 MBA1-like protein UPF0016 PF01169.14 KOH00502.1 - 4.5e-40 135.6 24.7 3.8e-21 75.0 4.7 2.4 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Mqo PF06039.10 KOH00502.1 - 0.021 13.0 0.1 0.029 12.5 0.0 1.1 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) DUF1673 PF07895.6 KOH00502.1 - 5.8 6.3 6.4 0.45 10.0 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1673) cwf18 PF08315.7 KOH00503.1 - 0.003 18.0 5.0 0.017 15.5 3.5 2.0 1 1 0 1 1 1 1 cwf18 pre-mRNA splicing factor IncA PF04156.9 KOH00503.1 - 0.49 9.9 5.7 0.14 11.7 2.1 1.4 2 0 0 2 2 2 0 IncA protein Cep57_CLD_2 PF14197.1 KOH00503.1 - 1.4 8.8 7.6 6.8 6.7 0.6 2.5 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 Ribosomal_L21e PF01157.13 KOH00505.1 - 3.9e-46 154.8 6.8 4.9e-46 154.5 4.2 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.4 KOH00505.1 - 0.022 14.1 0.0 0.026 13.8 0.0 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Mito_carr PF00153.22 KOH00506.1 - 3.1e-79 260.7 3.0 7.4e-30 102.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein ACCA PF03255.9 KOH00506.1 - 0.076 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Med8 PF10232.4 KOH00507.1 - 5.8e-59 199.3 2.1 6.5e-59 199.1 1.5 1.0 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 DUF2421 PF10334.4 KOH00507.1 - 0.041 13.5 0.0 0.065 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2421) DUF240 PF03086.9 KOH00507.1 - 0.06 12.9 1.1 0.35 10.5 0.1 2.1 2 0 0 2 2 2 0 MG032/MG096/MG288 family 2 Aha1_N PF09229.6 KOH00507.1 - 0.072 12.9 0.1 0.25 11.1 0.0 2.0 2 0 0 2 2 2 0 Activator of Hsp90 ATPase, N-terminal NpwBP PF12622.2 KOH00508.1 - 5e-08 33.2 0.3 1.1e-07 32.2 0.0 1.7 2 0 0 2 2 2 1 mRNA biogenesis factor DivIC PF04977.10 KOH00508.1 - 0.21 11.1 4.7 0.35 10.3 3.3 1.3 1 0 0 1 1 1 0 Septum formation initiator WD40 PF00400.27 KOH00509.1 - 1.4e-19 69.1 9.5 6.1e-05 22.7 0.0 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 KOH00509.1 - 6.6e-18 64.3 0.6 1.5e-17 63.2 0.4 1.6 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex eIF2A PF08662.6 KOH00509.1 - 9.6e-08 31.9 1.3 0.0005 19.8 0.1 3.3 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.7 KOH00509.1 - 0.0091 13.8 1.1 0.14 9.9 0.0 2.1 2 0 0 2 2 2 2 IKI3 family MAAL_N PF05034.8 KOH00509.1 - 0.023 14.4 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase N-terminus SdiA-regulated PF06977.6 KOH00509.1 - 0.11 11.4 0.1 12 4.7 0.0 2.7 2 1 0 2 2 2 0 SdiA-regulated PGI PF00342.14 KOH00510.1 - 1.5e-226 752.5 1.5 1.9e-226 752.1 1.1 1.1 1 0 0 1 1 1 1 Phosphoglucose isomerase TRF PF08558.5 KOH00511.1 - 0.0027 17.1 0.2 0.0042 16.4 0.1 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) WD40 PF00400.27 KOH00512.1 - 2.3e-61 201.6 19.9 1.1e-11 44.1 0.2 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat TFIID_90kDa PF04494.10 KOH00512.1 - 8.8e-51 171.7 1.0 1.7e-50 170.7 0.7 1.5 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit LisH PF08513.6 KOH00512.1 - 1.2e-06 28.0 0.1 3e-06 26.7 0.1 1.8 1 0 0 1 1 1 1 LisH Nup160 PF11715.3 KOH00512.1 - 1.1e-05 23.8 1.2 0.28 9.2 0.0 3.8 1 1 2 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 KOH00512.1 - 0.0021 16.8 0.5 0.063 12.0 0.3 3.1 1 1 0 1 1 1 1 Nup133 N terminal like Cytochrom_D1 PF02239.11 KOH00512.1 - 0.035 12.4 0.1 0.17 10.1 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain Glyco_transf_15 PF01793.11 KOH00513.1 - 5.9e-119 396.8 10.3 7.5e-119 396.5 7.1 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase T4SS PF07996.6 KOH00513.1 - 0.15 11.9 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 Type IV secretion system proteins SH3_1 PF00018.23 KOH00514.1 - 2.1e-24 84.6 0.0 2.1e-11 42.9 0.0 2.6 2 0 0 2 2 2 2 SH3 domain PX PF00787.19 KOH00514.1 - 2.5e-17 62.6 0.0 4.8e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 PX domain SH3_9 PF14604.1 KOH00514.1 - 6.6e-14 51.2 1.0 2.5e-10 39.7 0.0 3.1 3 0 0 3 3 3 2 Variant SH3 domain PB1 PF00564.19 KOH00514.1 - 1.4e-09 37.4 0.3 3.4e-09 36.2 0.2 1.7 1 0 0 1 1 1 1 PB1 domain SH3_2 PF07653.12 KOH00514.1 - 3.6e-08 32.7 0.1 1.9e-07 30.4 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain DER1 PF04511.10 KOH00515.1 - 1.5e-49 168.1 9.6 1.7e-49 168.0 6.7 1.0 1 0 0 1 1 1 1 Der1-like family RVT_1 PF00078.22 KOH00515.1 - 0.016 14.5 0.1 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) COX7C PF02935.11 KOH00516.1 - 0.06 13.1 0.1 0.093 12.5 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIc MCM PF00493.18 KOH00517.1 - 1.6e-134 447.9 0.1 3.5e-134 446.7 0.0 1.6 2 0 0 2 2 2 1 MCM2/3/5 family MCM_N PF14551.1 KOH00517.1 - 2.5e-26 92.5 1.9 1.9e-25 89.6 1.3 2.6 1 1 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 KOH00517.1 - 7.3e-08 31.8 0.0 1.1e-05 24.6 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KOH00517.1 - 2.4e-06 27.3 0.0 1.1e-05 25.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase_2 PF13335.1 KOH00517.1 - 0.0014 19.0 0.2 0.0059 16.9 0.1 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF455 PF04305.9 KOH00517.1 - 0.002 17.4 0.1 0.0038 16.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF455) Sigma54_activat PF00158.21 KOH00517.1 - 0.024 14.0 0.0 0.6 9.5 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.6 KOH00517.1 - 0.055 13.0 0.0 0.19 11.3 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 KOH00517.1 - 0.13 12.4 1.5 0.43 10.7 0.0 2.7 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) F-box-like PF12937.2 KOH00518.1 - 0.00012 21.7 0.0 0.00028 20.5 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 KOH00518.1 - 0.00042 19.8 0.0 0.0019 17.7 0.0 2.1 1 0 0 1 1 1 1 F-box domain Abhydrolase_1 PF00561.15 KOH00519.1 - 3e-22 79.3 0.0 2e-21 76.6 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOH00519.1 - 3.2e-19 69.7 0.0 4.5e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOH00519.1 - 1.1e-12 47.9 0.0 2.1e-12 47.0 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF2305 PF10230.4 KOH00519.1 - 2.1e-07 30.6 0.0 3.2e-07 30.0 0.0 1.6 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) PGAP1 PF07819.8 KOH00519.1 - 7.3e-05 22.4 0.0 0.00049 19.7 0.0 2.0 1 1 0 1 1 1 1 PGAP1-like protein Ser_hydrolase PF06821.8 KOH00519.1 - 0.0031 17.1 0.0 0.0054 16.3 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase Hydrolase_4 PF12146.3 KOH00519.1 - 0.012 15.4 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Putative lysophospholipase DUF3089 PF11288.3 KOH00519.1 - 0.085 11.9 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Glyco_transf_15 PF01793.11 KOH00520.1 - 3.8e-141 469.8 10.0 4.7e-141 469.5 7.0 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase FTR1 PF03239.9 KOH00521.1 - 2.9e-113 377.8 1.9 3.4e-113 377.6 1.3 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Amidase PF01425.16 KOH00522.1 - 1.2e-99 334.1 0.0 1.7e-99 333.6 0.0 1.2 1 0 0 1 1 1 1 Amidase AHS2 PF02626.10 KOH00522.1 - 5.9e-85 284.8 0.0 1.3e-84 283.7 0.0 1.6 1 0 0 1 1 1 1 Allophanate hydrolase subunit 2 CPSase_L_D2 PF02786.12 KOH00522.1 - 1.7e-63 213.7 0.0 3.1e-63 212.8 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain AHS1 PF02682.11 KOH00522.1 - 5.7e-44 149.9 0.0 1.3e-43 148.8 0.0 1.6 1 0 0 1 1 1 1 Allophanate hydrolase subunit 1 CPSase_L_chain PF00289.17 KOH00522.1 - 3.8e-39 133.2 0.0 1.3e-38 131.4 0.0 2.0 2 0 0 2 2 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 KOH00522.1 - 5.6e-32 109.9 0.0 1.4e-31 108.6 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 KOH00522.1 - 1.5e-18 67.1 0.0 3.5e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.17 KOH00522.1 - 1.1e-17 63.3 0.2 3.2e-17 61.9 0.2 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 KOH00522.1 - 9.2e-15 54.2 0.0 8.8e-10 37.8 0.0 2.2 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 KOH00522.1 - 2.7e-12 46.5 0.0 6.1e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 KOH00522.1 - 4.5e-06 26.1 0.1 1.6e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.6 KOH00522.1 - 7.4e-06 25.5 0.0 3.1e-05 23.5 0.0 2.1 2 1 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 KOH00522.1 - 0.00088 19.1 0.0 0.0017 18.2 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.1 KOH00522.1 - 0.0077 15.4 0.0 0.022 13.9 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain RnfC_N PF13375.1 KOH00522.1 - 0.018 14.7 0.0 0.049 13.3 0.0 1.7 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Toxin_59 PF15537.1 KOH00522.1 - 0.048 13.7 0.5 0.37 10.8 0.0 2.6 3 0 0 3 3 3 0 Putative toxin 59 Cornichon PF03311.9 KOH00523.1 - 5.7e-46 155.7 8.1 6.4e-46 155.6 5.6 1.0 1 0 0 1 1 1 1 Cornichon protein DUF716 PF04819.7 KOH00523.1 - 0.59 9.5 4.2 6.6 6.1 0.1 2.4 3 0 0 3 3 3 0 Family of unknown function (DUF716) FA_desaturase PF00487.19 KOH00523.1 - 1.7 8.0 4.5 2.3 7.6 3.1 1.2 1 0 0 1 1 1 0 Fatty acid desaturase DivIC PF04977.10 KOH00524.1 - 9.7 5.7 11.2 0.21 11.0 2.6 2.1 2 1 0 2 2 2 0 Septum formation initiator RRM_1 PF00076.17 KOH00525.1 - 1.2e-43 146.5 0.0 1.3e-16 60.0 0.0 4.3 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOH00525.1 - 2.3e-28 97.9 0.0 4e-12 45.9 0.0 3.7 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOH00525.1 - 5.6e-19 67.7 0.0 9.7e-08 31.7 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KOH00525.1 - 3.1e-06 26.8 0.0 3.6e-05 23.4 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 KOH00525.1 - 0.22 11.4 0.0 0.22 11.4 0.0 2.8 4 1 0 4 4 4 0 RNA binding motif NAD_binding_7 PF13241.1 KOH00526.1 - 1e-26 93.1 0.0 1.8e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.1 KOH00526.1 - 1.8e-23 81.6 0.0 3.9e-23 80.5 0.0 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.1 KOH00526.1 - 2.2e-14 52.1 0.1 5e-14 50.9 0.1 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Shikimate_DH PF01488.15 KOH00526.1 - 0.015 15.4 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CBS PF00571.23 KOH00527.1 - 5.7e-22 77.2 0.1 0.0008 19.1 0.0 5.4 5 0 0 5 5 5 5 CBS domain DUF2981 PF11200.3 KOH00527.1 - 1.4 7.8 4.7 2.7 7.0 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) HUN PF08729.5 KOH00528.1 - 3.3e-13 49.2 0.0 3.3e-13 49.2 0.0 2.1 2 0 0 2 2 2 1 HPC2 and ubinuclein domain Kinetochor_Ybp2 PF08568.5 KOH00529.1 - 2.1e-152 508.6 15.8 2.5e-152 508.3 11.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin APG12 PF04110.8 KOH00530.1 - 2.3e-32 111.0 0.2 4.5e-32 110.0 0.1 1.5 2 0 0 2 2 2 1 Ubiquitin-like autophagy protein Apg12 Topoisom_I_N PF02919.10 KOH00530.1 - 0.0049 16.2 0.1 0.0057 15.9 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, DNA binding fragment GcrA PF07750.6 KOH00530.1 - 0.035 14.2 0.3 0.048 13.8 0.2 1.3 1 0 0 1 1 1 0 GcrA cell cycle regulator BPL_N PF09825.4 KOH00530.1 - 0.054 12.2 0.9 0.06 12.1 0.6 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF3713 PF12506.3 KOH00530.1 - 3.5 7.7 10.0 0.51 10.4 3.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3713) CPSase_L_D2 PF02786.12 KOH00531.1 - 8.6e-84 280.0 0.0 1.5e-83 279.2 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.13 KOH00531.1 - 6e-66 221.6 0.0 9.5e-66 220.9 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain CPSase_L_chain PF00289.17 KOH00531.1 - 1.1e-35 122.0 0.0 2.4e-35 120.9 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 KOH00531.1 - 5e-31 106.8 0.0 1.9e-30 104.9 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.14 KOH00531.1 - 2.5e-29 102.6 0.0 5.2e-29 101.5 0.0 1.5 1 0 0 1 1 1 1 HMGL-like ATPgrasp_Ter PF15632.1 KOH00531.1 - 3.2e-19 68.8 0.0 1.2e-18 66.9 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl PF00364.17 KOH00531.1 - 2.5e-18 65.5 5.8 2.5e-18 65.5 4.0 2.4 3 0 0 3 3 3 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 KOH00531.1 - 1.2e-16 60.9 0.1 2.3e-16 60.0 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 KOH00531.1 - 4.8e-08 32.5 4.0 0.00075 19.1 0.3 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.8 KOH00531.1 - 1.5e-07 31.0 0.0 3e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 KOH00531.1 - 8.9e-07 28.4 0.0 1.7e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.6 KOH00531.1 - 1.4e-05 24.6 0.0 4.1e-05 23.1 0.0 1.8 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 KOH00531.1 - 3.5e-05 23.7 0.0 9.2e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain HlyD PF00529.15 KOH00531.1 - 0.0012 18.2 1.2 0.19 11.0 0.0 2.7 3 0 0 3 3 3 1 HlyD family secretion protein HlyD_2 PF12700.2 KOH00531.1 - 0.0057 15.8 1.2 1.2 8.2 0.0 2.3 1 1 1 2 2 2 2 HlyD family secretion protein HlyD_3 PF13437.1 KOH00531.1 - 0.011 16.0 1.6 6.7 7.1 0.0 3.5 3 0 0 3 3 3 0 HlyD family secretion protein GCV_H PF01597.14 KOH00531.1 - 0.14 11.8 0.7 0.31 10.7 0.5 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein Acatn PF13000.2 KOH00532.1 - 0 1034.0 19.8 0 1033.8 13.7 1.0 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Transket_pyr PF02779.19 KOH00533.1 - 9.1e-48 162.0 0.0 3.6e-47 160.1 0.0 1.8 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 KOH00533.1 - 1.6e-36 124.9 0.2 3.3e-36 123.9 0.1 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain GntR PF00392.16 KOH00533.1 - 0.036 13.4 0.5 4.4 6.8 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family AMP-binding PF00501.23 KOH00534.1 - 2.9e-72 243.3 0.0 4.7e-72 242.6 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 KOH00534.1 - 3.8e-17 62.9 0.1 1.1e-16 61.5 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NSP11 PF06471.7 KOH00534.1 - 0.016 13.4 0.2 0.062 11.4 0.0 1.9 2 0 0 2 2 2 0 NSP11 Tyr-DNA_phospho PF06087.7 KOH00535.1 - 1.7e-108 363.1 0.1 2e-108 362.8 0.1 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase Methyltransf_11 PF08241.7 KOH00536.1 - 0.0078 16.6 0.0 0.031 14.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain PNPase_C PF12111.3 KOH00536.1 - 3.9 6.7 7.3 12 5.2 0.7 2.6 2 0 0 2 2 2 0 Polyribonucleotide phosphorylase C terminal AAA_2 PF07724.9 KOH00537.1 - 6.5e-36 123.8 0.9 3.3e-35 121.5 0.6 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 KOH00537.1 - 5.9e-15 55.6 0.3 1.2e-14 54.6 0.2 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 KOH00537.1 - 2.9e-08 33.4 0.0 7.7e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 KOH00537.1 - 3.2e-08 33.3 0.0 7.7e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 KOH00537.1 - 4.3e-06 26.9 0.2 4.6e-05 23.5 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOH00537.1 - 1.3e-05 25.3 0.2 5.2e-05 23.3 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 KOH00537.1 - 2e-05 25.3 2.4 3.6e-05 24.5 0.1 2.6 3 1 0 3 3 2 1 AAA domain Mg_chelatase PF01078.16 KOH00537.1 - 3.3e-05 23.1 0.1 0.002 17.3 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 KOH00537.1 - 0.00014 21.4 0.1 0.033 13.6 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain RuvB_N PF05496.7 KOH00537.1 - 0.00081 18.5 0.0 0.0023 17.0 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 KOH00537.1 - 0.00089 19.1 0.1 0.0028 17.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 KOH00537.1 - 0.0012 18.2 0.1 0.0035 16.7 0.0 1.7 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_24 PF13479.1 KOH00537.1 - 0.0012 18.4 0.1 0.0037 16.8 0.1 1.8 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 KOH00537.1 - 0.0023 16.8 0.0 0.0039 16.1 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein Sigma54_activ_2 PF14532.1 KOH00537.1 - 0.0028 17.7 0.0 0.008 16.2 0.0 1.8 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_33 PF13671.1 KOH00537.1 - 0.0055 16.5 0.0 0.018 14.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain MCM PF00493.18 KOH00537.1 - 0.0057 15.4 0.2 0.016 14.0 0.1 1.7 1 1 0 1 1 1 1 MCM2/3/5 family DEAD PF00270.24 KOH00537.1 - 0.0061 16.0 1.2 0.24 10.8 0.0 3.3 3 1 1 4 4 4 1 DEAD/DEAH box helicase AAA_18 PF13238.1 KOH00537.1 - 0.0084 16.4 3.2 0.0087 16.3 0.5 2.4 2 1 0 2 2 2 1 AAA domain PhoH PF02562.11 KOH00537.1 - 0.0088 15.2 0.0 0.019 14.1 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein NACHT PF05729.7 KOH00537.1 - 0.016 14.8 0.1 0.11 12.1 0.0 2.3 2 0 0 2 2 2 0 NACHT domain AAA_29 PF13555.1 KOH00537.1 - 0.029 13.8 0.0 0.065 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MobB PF03205.9 KOH00537.1 - 0.031 13.9 0.3 0.12 12.0 0.1 2.1 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 KOH00537.1 - 0.037 14.1 0.0 0.19 11.8 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_19 PF13245.1 KOH00537.1 - 0.049 13.3 0.1 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain CbiA PF01656.18 KOH00537.1 - 0.076 12.4 1.6 0.12 11.7 0.7 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.22 KOH00537.1 - 0.093 13.0 2.0 0.1 12.9 0.3 2.1 1 1 0 1 1 1 0 ABC transporter AAA_23 PF13476.1 KOH00537.1 - 2.7 8.2 14.4 0.23 11.7 2.2 3.0 1 1 1 2 2 2 0 AAA domain GIY-YIG PF01541.19 KOH00538.1 - 1e-09 38.5 0.2 3.1e-09 37.0 0.0 1.9 2 0 0 2 2 2 1 GIY-YIG catalytic domain FANCL_C PF11793.3 KOH00538.1 - 5.9e-06 26.1 4.7 1.9e-05 24.5 3.2 1.9 1 0 0 1 1 1 1 FANCL C-terminal domain zinc_ribbon_5 PF13719.1 KOH00538.1 - 0.022 14.3 0.4 0.89 9.1 0.1 3.0 2 1 0 2 2 2 0 zinc-ribbon domain zf-RING_2 PF13639.1 KOH00538.1 - 0.027 14.2 4.1 0.063 13.1 2.8 1.7 1 0 0 1 1 1 0 Ring finger domain zinc_ribbon_4 PF13717.1 KOH00538.1 - 0.045 13.4 0.8 0.84 9.3 0.1 2.9 2 1 0 2 2 2 0 zinc-ribbon domain zf-RING-like PF08746.6 KOH00538.1 - 0.083 12.9 0.9 0.083 12.9 0.6 2.6 3 0 0 3 3 3 0 RING-like domain DUF329 PF03884.9 KOH00538.1 - 0.43 10.1 4.3 9.2 5.9 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF329) Glyco_hydro_31 PF01055.21 KOH00539.1 - 3.4e-146 487.5 0.3 5.2e-146 486.9 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 KOH00539.1 - 2.2e-20 72.2 1.1 1.6e-19 69.5 0.1 2.9 3 0 0 3 3 3 1 Galactose mutarotase-like Myotoxins PF00819.12 KOH00539.1 - 0.11 12.6 0.1 23 5.1 0.0 2.6 2 0 0 2 2 2 0 Myotoxin CDC45 PF02724.9 KOH00541.1 - 0.085 10.8 22.1 0.12 10.3 15.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 KOH00541.1 - 0.14 10.6 27.7 0.17 10.3 19.2 1.0 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 KOH00541.1 - 0.3 8.9 25.8 0.35 8.7 17.9 1.1 1 0 0 1 1 1 0 Nop14-like family KH_1 PF00013.24 KOH00542.1 - 6.4e-35 118.6 1.7 3.1e-10 39.5 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 KOH00542.1 - 3.6e-25 87.1 8.3 5.7e-09 35.4 1.0 3.5 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 KOH00542.1 - 2.6e-10 39.7 0.3 0.071 12.6 0.0 3.5 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 KOH00542.1 - 2.8e-06 26.8 0.9 0.08 12.5 0.0 3.2 3 0 0 3 3 3 2 KH domain Mcm10 PF09332.6 KOH00542.1 - 0.12 11.6 0.3 0.25 10.6 0.2 1.4 1 0 0 1 1 1 0 Mcm10 replication factor KH_5 PF13184.1 KOH00542.1 - 0.13 12.0 1.1 16 5.3 0.0 3.3 3 0 0 3 3 3 0 NusA-like KH domain DASH_Dad3 PF08656.5 KOH00543.1 - 1.3e-28 98.5 4.3 1.5e-28 98.2 3.0 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad3 COG6 PF06419.6 KOH00543.1 - 0.054 11.6 2.1 0.05 11.7 1.4 1.0 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 WD40 PF00400.27 KOH00544.1 - 1.6e-15 56.3 13.3 6.2e-05 22.7 0.2 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat Rax2 PF12768.2 KOH00544.1 - 0.0014 17.8 0.1 0.0025 17.0 0.1 1.3 1 0 0 1 1 1 1 Cortical protein marker for cell polarity AA_permease PF00324.16 KOH00545.1 - 2.1e-44 151.7 36.8 3.3e-44 151.0 25.5 1.3 1 0 0 1 1 1 1 Amino acid permease Pox_MCEL PF03291.11 KOH00546.1 - 5.4e-103 344.3 0.0 5.4e-103 344.3 0.0 1.4 2 0 0 2 2 1 1 mRNA capping enzyme Methyltransf_23 PF13489.1 KOH00546.1 - 4.9e-09 36.1 0.0 9.4e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOH00546.1 - 6.4e-09 36.1 0.1 2e-08 34.6 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOH00546.1 - 5.8e-08 33.2 0.0 1e-07 32.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOH00546.1 - 6.3e-08 33.0 0.0 1.3e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOH00546.1 - 1.3e-06 28.0 0.0 3.1e-06 26.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOH00546.1 - 1.5e-06 28.5 0.0 2.8e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 KOH00546.1 - 0.00053 19.0 0.0 0.0013 17.7 0.0 1.6 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_26 PF13659.1 KOH00546.1 - 0.00058 19.8 0.0 0.001 19.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 KOH00546.1 - 0.0037 16.3 0.0 0.0073 15.3 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase CMAS PF02353.15 KOH00546.1 - 0.0085 15.1 0.0 0.032 13.3 0.0 1.8 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase MetW PF07021.7 KOH00546.1 - 0.05 12.9 0.0 0.098 12.0 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW TPMT PF05724.6 KOH00546.1 - 0.054 12.9 0.0 0.13 11.7 0.0 1.5 2 0 0 2 2 2 0 Thiopurine S-methyltransferase (TPMT) DUF3682 PF12446.3 KOH00546.1 - 0.15 12.3 3.3 0.24 11.7 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) DEAD PF00270.24 KOH00547.1 - 5e-42 143.2 0.0 1.3e-41 141.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOH00547.1 - 5.4e-18 64.6 0.4 1.5e-17 63.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 KOH00547.1 - 2.2e-05 23.4 0.0 4.3e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C_2 PF13307.1 KOH00547.1 - 0.34 10.8 0.0 0.34 10.8 0.0 2.5 2 1 0 2 2 2 0 Helicase C-terminal domain PAS PF00989.19 KOH00549.1 - 3e-19 68.8 0.0 5e-19 68.1 0.0 1.4 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.13 KOH00549.1 - 1.3e-07 31.3 7.6 2.4e-07 30.5 5.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CpeT PF06206.6 KOH00549.1 - 0.012 15.2 0.1 0.042 13.5 0.0 1.8 2 0 0 2 2 2 0 CpeT/CpcT family (DUF1001) PAS_9 PF13426.1 KOH00549.1 - 0.019 15.3 0.0 0.052 13.9 0.0 1.7 1 0 0 1 1 1 0 PAS domain PAS_4 PF08448.5 KOH00549.1 - 0.11 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 PAS fold Zn_clus PF00172.13 KOH00550.1 - 8.7e-12 44.7 6.4 4.5e-11 42.4 4.4 2.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Competence PF03772.11 KOH00551.1 - 0.067 12.2 1.3 0.11 11.5 0.9 1.2 1 0 0 1 1 1 0 Competence protein Sugar_tr PF00083.19 KOH00552.1 - 1.5e-110 369.8 18.0 1.9e-110 369.5 12.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOH00552.1 - 6e-30 104.1 47.5 3.1e-29 101.8 15.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily HD_3 PF13023.1 KOH00553.1 - 1.4e-35 122.4 0.1 1.8e-35 122.0 0.0 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.17 KOH00553.1 - 4.4e-06 26.7 2.0 2.6e-05 24.2 1.4 2.0 1 1 0 1 1 1 1 HD domain Glycos_transf_4 PF00953.16 KOH00554.1 - 1.9e-31 109.0 9.6 1.9e-31 109.0 6.7 2.1 2 1 0 2 2 2 1 Glycosyl transferase family 4 DUF4006 PF13179.1 KOH00554.1 - 7.2 6.2 6.1 23 4.6 0.2 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF4006) GSHPx PF00255.14 KOH00555.1 - 2.1e-48 162.1 1.8 2.8e-48 161.7 1.3 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 KOH00555.1 - 1.9e-06 27.5 0.8 1.6e-05 24.5 0.6 2.0 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KOH00555.1 - 1.1e-05 25.0 0.4 7.1e-05 22.3 0.3 2.0 1 1 0 1 1 1 1 Redoxin SCO1-SenC PF02630.9 KOH00555.1 - 0.003 17.2 0.6 0.055 13.0 0.1 2.2 2 0 0 2 2 2 1 SCO1/SenC SNF2_N PF00176.18 KOH00556.1 - 2.5e-82 276.0 0.3 4.5e-82 275.2 0.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 KOH00556.1 - 1.3e-40 137.8 2.8 1.3e-40 137.8 1.9 3.5 4 0 0 4 4 4 1 SLIDE HAND PF09110.6 KOH00556.1 - 4.8e-35 120.3 1.0 4.8e-35 120.3 0.7 3.8 5 0 0 5 5 5 1 HAND Helicase_C PF00271.26 KOH00556.1 - 1.2e-14 53.9 0.0 3.2e-14 52.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOH00556.1 - 4.2e-10 39.7 4.3 5.5e-09 36.1 0.0 4.3 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.24 KOH00556.1 - 3.3e-05 23.4 0.0 7.5e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase XRN_N PF03159.13 KOH00556.1 - 0.0027 17.1 0.1 0.0098 15.3 0.0 2.0 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus DEAD_2 PF06733.10 KOH00556.1 - 0.0079 15.6 0.1 0.018 14.4 0.1 1.6 1 0 0 1 1 1 1 DEAD_2 AAA_14 PF13173.1 KOH00556.1 - 0.0083 16.0 0.1 0.054 13.3 0.0 2.5 1 0 0 1 1 1 1 AAA domain WD40 PF00400.27 KOH00557.1 - 0.00041 20.1 15.6 0.21 11.5 0.2 5.1 6 0 0 6 6 6 4 WD domain, G-beta repeat Bystin PF05291.6 KOH00558.1 - 1e-120 402.2 0.0 1.8e-120 401.4 0.0 1.4 1 0 0 1 1 1 1 Bystin His_biosynth PF00977.16 KOH00559.1 - 2.9e-44 151.0 0.2 4.1e-43 147.2 0.1 2.8 2 1 0 2 2 2 1 Histidine biosynthesis protein GATase PF00117.23 KOH00559.1 - 1.8e-31 109.0 0.0 3e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.14 KOH00559.1 - 1.9e-07 30.9 0.0 0.0011 18.6 0.0 2.3 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.9 KOH00559.1 - 1.3e-06 28.1 0.0 4.1e-06 26.4 0.0 1.8 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.8 KOH00559.1 - 0.00018 21.0 0.1 0.13 11.7 0.0 2.3 2 0 0 2 2 2 2 Peptidase C26 DJ-1_PfpI PF01965.19 KOH00559.1 - 0.037 13.4 0.0 0.1 12.0 0.0 1.7 2 0 0 2 2 2 0 DJ-1/PfpI family ThiG PF05690.9 KOH00559.1 - 0.055 12.5 0.0 0.098 11.7 0.0 1.4 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG DAHP_synth_1 PF00793.15 KOH00560.1 - 1.1e-105 352.2 0.1 1.4e-105 351.8 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Arrestin_N PF00339.24 KOH00561.1 - 4.1e-07 29.9 0.8 8.8e-07 28.8 0.3 1.7 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain YceI PF04264.8 KOH00561.1 - 0.031 14.2 0.2 0.077 12.9 0.1 1.6 1 1 0 1 1 1 0 YceI-like domain Ribosomal_S5 PF00333.15 KOH00562.1 - 6e-26 89.9 0.3 1.3e-25 88.9 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 KOH00562.1 - 7.6e-18 63.5 0.0 2e-17 62.2 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain dUTPase PF00692.14 KOH00563.1 - 2e-44 150.1 0.1 2.8e-44 149.6 0.1 1.2 1 0 0 1 1 1 1 dUTPase Med22 PF06179.7 KOH00564.1 - 6.4e-23 80.8 4.8 7.6e-23 80.6 3.3 1.0 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex TMCO5 PF14992.1 KOH00564.1 - 0.00092 18.4 3.4 0.0011 18.1 2.4 1.1 1 0 0 1 1 1 1 TMCO5 family DUF3246 PF11596.3 KOH00564.1 - 0.013 14.7 0.2 0.017 14.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Sedlin_N PF04628.8 KOH00565.1 - 3.2e-49 166.1 0.0 3.7e-49 165.9 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 KOH00565.1 - 4.1e-07 29.7 0.1 5.7e-07 29.3 0.1 1.6 1 1 0 1 1 1 1 Sybindin-like family Pox_ser-thr_kin PF05445.6 KOH00567.1 - 0.083 11.6 0.0 0.084 11.6 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Lum_binding PF00677.12 KOH00568.1 - 7.7e-54 179.5 5.0 2.7e-26 91.2 0.3 2.4 2 0 0 2 2 2 2 Lumazine binding domain PilZ PF07238.9 KOH00568.1 - 0.091 12.7 0.2 3.3 7.7 0.0 2.5 1 1 1 2 2 2 0 PilZ domain UPF0086 PF01868.11 KOH00569.1 - 8.8e-15 54.1 0.0 1.7e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Methyltrans_Mon PF14314.1 KOH00569.1 - 0.00077 17.4 1.0 0.047 11.5 0.5 2.1 2 0 0 2 2 2 2 Virus-capping methyltransferase COMPASS-Shg1 PF05205.7 KOH00570.1 - 1.1e-26 93.2 5.2 1.4e-26 92.8 3.6 1.2 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 RhoGAP PF00620.22 KOH00572.1 - 1e-39 135.5 0.2 9.8e-39 132.3 0.0 2.5 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.18 KOH00572.1 - 1.2e-14 54.2 2.0 1.2e-14 54.2 1.4 2.5 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Fib_alpha PF08702.5 KOH00572.1 - 0.026 14.6 12.3 0.049 13.7 1.5 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Ead_Ea22 PF13935.1 KOH00572.1 - 0.038 14.3 1.7 0.36 11.1 0.2 2.3 1 1 1 2 2 2 0 Ead/Ea22-like protein ERG2_Sigma1R PF04622.7 KOH00572.1 - 0.12 11.6 0.2 0.2 10.8 0.2 1.3 1 0 0 1 1 1 0 ERG2 and Sigma1 receptor like protein Syntaxin_2 PF14523.1 KOH00572.1 - 1.4 9.0 7.3 1 9.4 2.9 2.5 2 1 0 2 2 2 0 Syntaxin-like protein Methyltransf_PK PF05891.7 KOH00573.1 - 1.2e-99 332.0 0.0 1.4e-99 331.7 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_23 PF13489.1 KOH00573.1 - 1.9e-07 30.9 0.0 4.1e-07 29.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOH00573.1 - 2.6e-05 24.7 0.0 4.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOH00573.1 - 0.00039 20.8 0.0 0.00071 20.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOH00573.1 - 0.0004 20.7 0.0 0.00071 19.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 KOH00573.1 - 0.038 13.1 0.2 0.22 10.6 0.1 2.0 1 1 0 1 1 1 0 O-methyltransferase SHMT PF00464.14 KOH00575.1 - 2.5e-208 691.2 0.0 2.9e-208 691.0 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Ras PF00071.17 KOH00576.1 - 6.6e-43 145.9 0.0 8.3e-43 145.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOH00576.1 - 8.1e-19 68.2 0.1 1.3e-18 67.6 0.1 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOH00576.1 - 3.5e-13 49.1 0.0 4.5e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KOH00576.1 - 3.2e-10 39.7 0.2 1.1e-09 38.0 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KOH00576.1 - 2.9e-08 33.1 0.1 4.2e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KOH00576.1 - 3.3e-07 30.2 0.0 5.1e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KOH00576.1 - 0.00053 19.2 0.1 0.0011 18.1 0.1 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.13 KOH00576.1 - 0.0017 17.6 0.1 0.014 14.7 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B G-alpha PF00503.15 KOH00576.1 - 0.0053 15.5 0.6 1.5 7.4 0.0 2.9 1 1 1 2 2 2 2 G-protein alpha subunit AAA_22 PF13401.1 KOH00576.1 - 0.012 15.7 0.1 0.026 14.6 0.1 1.5 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 KOH00576.1 - 0.021 14.3 0.2 0.21 11.1 0.2 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF258 PF03193.11 KOH00576.1 - 0.049 12.8 0.3 0.084 12.0 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function, DUF258 adh_short PF00106.20 KOH00577.1 - 1.2e-19 70.8 0.0 3.4e-19 69.3 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOH00577.1 - 2.4e-10 40.3 0.0 3.7e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 KOH00577.1 - 0.0011 18.7 0.0 0.0015 18.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.10 KOH00577.1 - 0.0018 17.2 0.0 0.0043 15.9 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein zf-C2H2_2 PF12756.2 KOH00578.1 - 1.3e-33 115.0 5.5 4.4e-31 106.9 2.1 2.5 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.7 KOH00578.1 - 0.052 13.3 5.5 1.4 8.6 0.2 3.1 2 1 1 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) Hepcidin PF06446.7 KOH00578.1 - 0.75 10.2 3.4 1.6 9.2 0.3 2.9 2 0 0 2 2 2 0 Hepcidin zf-C2H2_4 PF13894.1 KOH00578.1 - 2.2 8.8 9.2 1.1 9.7 0.1 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger Ribosomal_L37 PF08561.5 KOH00579.1 - 3.5e-28 97.0 0.7 4.1e-28 96.7 0.5 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 DUF1674 PF07896.7 KOH00580.1 - 4.9e-17 61.8 1.3 7.2e-17 61.3 0.9 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) HbrB PF08539.6 KOH00581.1 - 1.1e-39 135.8 1.4 2.2e-39 134.8 1.0 1.5 1 0 0 1 1 1 1 HbrB-like Methyltransf_16 PF10294.4 KOH00582.1 - 1.2e-23 83.4 0.0 2.1e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_31 PF13847.1 KOH00582.1 - 9.8e-07 28.4 0.0 2.7e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOH00582.1 - 1.9e-05 25.1 0.0 5.8e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOH00582.1 - 4.1e-05 23.3 0.0 9.5e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOH00582.1 - 0.00046 19.6 0.0 0.00076 18.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 KOH00582.1 - 0.0077 16.6 0.0 0.026 15.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.10 KOH00582.1 - 0.021 14.2 0.0 0.049 13.0 0.0 1.6 1 1 0 1 1 1 0 Conserved hypothetical protein 95 Osmo_CC PF08946.5 KOH00582.1 - 0.031 14.2 1.3 0.18 11.8 0.3 2.4 2 0 0 2 2 2 0 Osmosensory transporter coiled coil Methyltransf_26 PF13659.1 KOH00582.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain KRTDAP PF15200.1 KOH00583.1 - 0.11 12.2 0.1 0.78 9.5 0.0 2.3 2 0 0 2 2 2 0 Keratinocyte differentiation-associated UBX PF00789.15 KOH00584.1 - 3.8e-22 78.1 0.1 1.8e-21 76.0 0.0 2.2 2 0 0 2 2 2 1 UBX domain Pkinase PF00069.20 KOH00585.1 - 5.5e-61 205.9 0.0 7.7e-61 205.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00585.1 - 1.8e-34 119.0 0.0 4e-34 117.8 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH00585.1 - 1.3e-06 27.5 0.0 2.1e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 KOH00585.1 - 0.01 14.6 0.1 0.025 13.4 0.0 1.6 2 0 0 2 2 2 0 Seadornavirus VP7 Choline_kinase PF01633.15 KOH00585.1 - 0.019 14.5 0.5 0.12 11.9 0.0 2.1 2 0 0 2 2 2 0 Choline/ethanolamine kinase PP1c_bdg PF10488.4 KOH00585.1 - 0.054 12.6 0.8 0.079 12.1 0.6 1.1 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region Kdo PF06293.9 KOH00585.1 - 0.055 12.5 0.0 0.092 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Rif1_N PF12231.3 KOH00586.1 - 3.3e-88 296.1 13.5 3.3e-88 296.1 9.4 2.3 2 0 0 2 2 2 1 Rap1-interacting factor 1 N terminal DSPc PF00782.15 KOH00587.1 - 1.4e-24 86.1 0.0 1.4e-18 66.7 0.0 3.4 2 1 0 3 3 3 3 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOH00587.1 - 0.00011 21.6 0.0 0.00024 20.4 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 KOH00587.1 - 0.016 15.2 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Histone PF00125.19 KOH00588.1 - 0.0022 18.0 0.1 0.0038 17.2 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KOH00588.1 - 0.0038 17.2 0.0 0.0073 16.3 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone LEDGF PF11467.3 KOH00588.1 - 0.017 14.7 0.2 0.037 13.7 0.1 1.5 1 0 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) CobT PF06213.7 KOH00588.1 - 0.091 11.8 15.3 0.12 11.4 10.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Zip PF02535.17 KOH00588.1 - 0.13 11.2 1.1 0.16 10.9 0.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SDA1 PF05285.7 KOH00588.1 - 0.39 9.9 14.7 0.48 9.6 10.2 1.3 1 0 0 1 1 1 0 SDA1 Trypan_PARP PF05887.6 KOH00588.1 - 2 8.1 11.9 3.2 7.5 8.3 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF2457 PF10446.4 KOH00588.1 - 2.2 6.9 19.8 2.9 6.5 13.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.7 KOH00588.1 - 7.4 4.3 20.3 8.4 4.1 14.1 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 KOH00588.1 - 7.8 4.4 14.2 9.8 4.0 9.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Paf1 PF03985.8 KOH00589.1 - 1.7e-151 504.8 20.4 2e-151 504.6 14.1 1.0 1 0 0 1 1 1 1 Paf1 RCC1_2 PF13540.1 KOH00590.1 - 1.9e-18 65.5 8.6 7.5e-10 38.1 1.4 4.7 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 KOH00590.1 - 3.2e-15 56.0 6.0 6.6e-05 23.0 0.2 6.3 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat Peptidase_M20 PF01546.23 KOH00591.1 - 3.8e-20 72.1 0.0 7.9e-20 71.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 KOH00591.1 - 1.7e-14 53.5 0.0 4.2e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain WD40 PF00400.27 KOH00591.1 - 1.8e-13 49.7 2.8 0.00071 19.3 0.0 6.0 5 0 0 5 5 5 4 WD domain, G-beta repeat DUF2392 PF10288.4 KOH00591.1 - 0.017 15.4 0.2 0.075 13.3 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2392) MRP-L27 PF09809.4 KOH00592.1 - 1.4e-31 108.4 0.4 2.1e-31 107.8 0.3 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 SecY PF00344.15 KOH00593.1 - 5.3e-56 190.0 22.3 7.2e-56 189.5 15.5 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 KOH00593.1 - 8.2e-09 34.8 0.1 3e-08 33.0 0.0 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p A_deaminase PF00962.17 KOH00594.1 - 4.3e-22 78.4 0.0 5.8e-14 51.7 0.0 2.5 2 1 0 2 2 2 2 Adenosine/AMP deaminase Peptidase_M28 PF04389.12 KOH00596.1 - 1.3e-35 122.7 0.0 2e-35 122.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 KOH00596.1 - 8.9e-12 44.5 0.0 1.8e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.23 KOH00596.1 - 0.0029 17.1 0.0 0.0041 16.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.9 KOH00596.1 - 0.0057 15.4 0.0 0.014 14.2 0.0 1.6 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase Mem_trans PF03547.13 KOH00597.1 - 9.5e-72 241.3 11.7 1.2e-71 241.1 8.1 1.1 1 0 0 1 1 1 1 Membrane transport protein CcoS PF03597.10 KOH00597.1 - 0.089 12.2 3.9 2.6 7.5 0.2 3.3 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type Adap_comp_sub PF00928.16 KOH00598.1 - 5e-42 143.8 0.3 1.7e-41 142.0 0.0 1.8 1 1 1 2 2 2 2 Adaptor complexes medium subunit family DUF3947 PF13135.1 KOH00598.1 - 0.3 11.3 4.3 0.57 10.4 3.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) SNF5 PF04855.7 KOH00599.1 - 6.7e-71 238.5 5.9 6.7e-71 238.5 4.1 4.8 3 2 0 3 3 3 1 SNF5 / SMARCB1 / INI1 DUF2370 PF10176.4 KOH00600.1 - 3.3e-86 288.4 0.1 4.7e-86 287.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) Sigma70_ner PF04546.8 KOH00600.1 - 0.0035 16.9 0.7 0.0064 16.1 0.5 1.4 1 0 0 1 1 1 1 Sigma-70, non-essential region Mito_carr PF00153.22 KOH00601.1 - 1.6e-66 220.0 0.8 8.1e-23 79.9 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.14 KOH00601.1 - 0.016 15.2 0.5 8.1 6.4 0.0 3.4 3 1 1 4 4 4 0 Tim17/Tim22/Tim23/Pmp24 family MFS_1 PF07690.11 KOH00602.1 - 5.5e-43 147.0 48.0 6.3e-41 140.2 33.3 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOH00602.1 - 8.9e-15 54.2 28.5 1e-14 53.9 9.7 3.2 2 1 1 3 3 3 2 Sugar (and other) transporter BatA PF07584.6 KOH00602.1 - 8.5 6.6 8.4 1.6 8.9 0.2 3.5 4 0 0 4 4 4 0 Aerotolerance regulator N-terminal Sulfate_transp PF00916.15 KOH00603.1 - 2e-85 286.2 4.8 2e-85 286.2 3.3 2.0 2 0 0 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 KOH00603.1 - 4.4e-31 106.3 3.0 1.7e-30 104.5 2.1 2.1 1 0 0 1 1 1 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 KOH00603.1 - 4.7e-08 32.4 0.0 2.2e-07 30.2 0.0 2.1 3 0 0 3 3 3 1 STAS domain STAS_2 PF13466.1 KOH00603.1 - 0.0022 17.9 0.0 0.0045 16.9 0.0 1.4 1 0 0 1 1 1 1 STAS domain PHO4 PF01384.15 KOH00604.1 - 1.4e-119 398.5 1.2 3e-119 397.5 0.8 1.5 1 1 0 1 1 1 1 Phosphate transporter family Tautomerase PF01361.16 KOH00604.1 - 0.037 13.6 0.0 0.092 12.3 0.0 1.6 1 0 0 1 1 1 0 Tautomerase enzyme MIP PF00230.15 KOH00605.1 - 8e-49 166.1 10.2 1.2e-48 165.6 7.1 1.2 1 0 0 1 1 1 1 Major intrinsic protein DUF340 PF03956.8 KOH00605.1 - 0.073 12.3 4.3 1.4 8.2 0.0 2.2 2 0 0 2 2 2 0 Membrane protein of unknown function (DUF340) NADH-u_ox-rdase PF10785.4 KOH00605.1 - 5.6 7.2 6.8 5 7.4 0.1 3.1 1 1 1 3 3 3 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Dak1 PF02733.12 KOH00606.1 - 6.6e-146 485.0 2.0 8.4e-146 484.6 1.4 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 KOH00606.1 - 5.9e-44 149.8 2.8 1.4e-43 148.5 2.0 1.7 1 0 0 1 1 1 1 DAK2 domain DUF1349 PF07081.6 KOH00607.1 - 9.6e-68 227.1 0.0 1.1e-67 226.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) Homeobox PF00046.24 KOH00611.1 - 5e-09 35.6 1.2 5e-09 35.6 0.8 1.7 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.6 KOH00611.1 - 7.1e-07 28.8 0.4 7.1e-07 28.8 0.3 2.2 3 0 0 3 3 3 1 Homeobox KN domain Homez PF11569.3 KOH00611.1 - 0.0076 15.2 0.2 0.058 12.4 0.0 2.1 1 1 1 2 2 2 1 Homeodomain leucine-zipper encoding, Homez Syntaxin-6_N PF09177.6 KOH00611.1 - 0.028 14.7 2.8 0.11 12.9 2.0 2.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Aurora-A_bind PF09041.5 KOH00611.1 - 0.069 12.9 0.1 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Aurora-A binding MAT_Alpha1 PF04769.7 KOH00612.1 - 2.3e-30 105.4 0.7 2.6e-30 105.2 0.5 1.0 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 MRP-S26 PF14943.1 KOH00613.1 - 0.022 14.3 2.3 0.054 13.0 1.6 1.6 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 SLX9 PF15341.1 KOH00613.1 - 3.5 8.0 10.2 0.36 11.2 0.1 2.7 3 0 0 3 3 3 0 Ribosome biogenesis protein SLX9 KH_1 PF00013.24 KOH00614.1 - 0.0026 17.3 0.3 0.0062 16.1 0.0 1.8 2 0 0 2 2 2 1 KH domain KH_3 PF13014.1 KOH00614.1 - 0.033 13.8 0.2 0.098 12.3 0.0 1.9 2 0 0 2 2 2 0 KH domain Spore_GerAC PF05504.6 KOH00614.1 - 2.6 7.8 9.4 41 3.9 3.4 3.0 2 1 1 3 3 3 0 Spore germination B3/ GerAC like, C-terminal MRP-L28 PF09812.4 KOH00615.1 - 2.3 8.0 7.9 2.8 7.7 5.5 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 DUF543 PF04418.7 KOH00616.1 - 4.1e-30 103.5 0.2 4.8e-30 103.3 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) DUF4386 PF14329.1 KOH00616.1 - 0.031 13.7 0.0 0.036 13.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) Peptidase_M3 PF01432.15 KOH00617.1 - 2.8e-158 527.7 1.3 3.4e-158 527.4 0.9 1.1 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.1 KOH00617.1 - 0.048 13.7 0.0 0.32 11.0 0.0 2.1 2 0 0 2 2 2 0 Effector protein ABA_GPCR PF12430.3 KOH00618.1 - 0.046 12.8 0.5 0.059 12.4 0.3 1.1 1 0 0 1 1 1 0 Abscisic acid G-protein coupled receptor MT-A70 PF05063.9 KOH00619.1 - 6.5e-14 51.8 0.0 1e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 MT-A70 EZH2_WD-Binding PF11616.3 KOH00619.1 - 0.048 13.5 1.5 0.1 12.4 1.1 1.5 1 0 0 1 1 1 0 WD repeat binding protein EZH2 Spb1_C PF07780.7 KOH00620.1 - 1.2e-75 253.6 25.3 1.2e-75 253.6 17.6 3.3 2 1 0 3 3 3 1 Spb1 C-terminal domain DUF3381 PF11861.3 KOH00620.1 - 2.3e-53 179.9 16.2 2.3e-53 179.9 11.2 4.8 4 2 1 5 5 5 1 Domain of unknown function (DUF3381) FtsJ PF01728.14 KOH00620.1 - 1.5e-51 174.9 0.1 1.5e-51 174.9 0.1 2.1 3 0 0 3 3 3 1 FtsJ-like methyltransferase PIG-X PF08320.7 KOH00621.1 - 2.9e-50 170.4 0.0 4e-50 169.9 0.0 1.2 1 0 0 1 1 1 1 PIG-X / PBN1 ATP_transf PF09830.4 KOH00623.1 - 3e-20 71.7 0.0 5.6e-20 70.9 0.0 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.18 KOH00623.1 - 0.06 13.8 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 HIT domain Recep_L_domain PF01030.19 KOH00625.1 - 1.7e-09 37.6 18.8 0.00042 20.2 0.0 4.8 2 1 1 5 5 5 3 Receptor L domain LRR_5 PF13306.1 KOH00625.1 - 0.0066 16.1 0.8 0.0066 16.1 0.5 2.9 1 1 2 3 3 3 1 Leucine rich repeats (6 copies) CTP_transf_2 PF01467.21 KOH00626.1 - 1.7e-05 24.8 0.2 0.00021 21.3 0.1 2.2 1 1 0 1 1 1 1 Cytidylyltransferase DUF1620 PF07774.8 KOH00627.1 - 8.5e-72 240.9 0.6 1.3e-71 240.2 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 KOH00627.1 - 0.0078 15.6 0.5 6 6.2 0.1 3.1 2 1 1 3 3 3 3 PQQ-like domain Mgr1 PF08602.5 KOH00628.1 - 1.7e-159 530.6 0.1 2e-159 530.4 0.1 1.0 1 0 0 1 1 1 1 Mgr1-like, i-AAA protease complex subunit Thioredoxin PF00085.15 KOH00629.1 - 4.1e-62 206.3 0.3 3.8e-30 103.6 0.1 3.3 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 KOH00629.1 - 2.3e-28 99.2 1.9 8.6e-19 68.0 0.8 3.4 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.1 KOH00629.1 - 1.1e-10 41.7 0.7 0.00047 20.3 0.1 3.6 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.1 KOH00629.1 - 2.6e-10 40.1 0.1 1.3e-05 25.0 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.1 KOH00629.1 - 1.5e-08 34.6 0.1 0.0069 16.4 0.0 3.5 3 1 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.16 KOH00629.1 - 1.3e-06 28.1 0.1 0.055 13.1 0.0 2.8 2 0 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.5 KOH00629.1 - 0.0034 16.9 0.2 0.51 9.8 0.0 2.5 2 0 0 2 2 2 1 Redoxin Thioredoxin_9 PF14595.1 KOH00629.1 - 0.019 14.5 0.3 7.5 6.1 0.0 2.9 3 0 0 3 3 3 0 Thioredoxin Thioredoxin_4 PF13462.1 KOH00629.1 - 0.17 11.8 3.1 8.7 6.3 0.0 3.2 3 1 0 3 3 3 0 Thioredoxin Hexokinase_2 PF03727.11 KOH00630.1 - 9.7e-92 306.5 0.0 1.4e-91 306.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KOH00630.1 - 2.3e-77 258.9 0.0 5.3e-77 257.8 0.0 1.6 2 0 0 2 2 2 1 Hexokinase PqqD PF05402.7 KOH00630.1 - 0.044 13.8 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) WD40 PF00400.27 KOH00631.1 - 1.6e-11 43.5 8.2 0.0096 15.7 0.0 5.9 7 0 0 7 7 7 3 WD domain, G-beta repeat DUF4221 PF13970.1 KOH00631.1 - 3.4e-05 23.3 0.1 9.5e-05 21.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4221) ATG22 PF11700.3 KOH00632.1 - 5.2e-161 536.3 30.3 5.9e-161 536.1 21.0 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.11 KOH00632.1 - 5.8e-06 25.2 44.2 2.6e-05 23.1 13.6 3.4 2 2 1 3 3 3 2 Major Facilitator Superfamily La PF05383.12 KOH00633.1 - 1.9e-19 69.2 0.1 4.5e-19 68.0 0.0 1.7 2 0 0 2 2 2 1 La domain Glutaredoxin PF00462.19 KOH00634.1 - 4.8e-15 55.2 0.0 7.5e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.1 KOH00634.1 - 0.0014 18.4 0.1 0.0028 17.4 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin domain Thioredoxin_9 PF14595.1 KOH00634.1 - 0.013 15.0 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin MafB19-deam PF14437.1 KOH00634.1 - 0.036 13.7 0.0 0.43 10.2 0.0 2.0 1 1 1 2 2 2 0 MafB19-like deaminase DSBA PF01323.15 KOH00634.1 - 0.043 13.3 0.5 2.6 7.5 0.0 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.1 KOH00634.1 - 0.07 13.3 0.2 0.11 12.6 0.1 1.5 1 1 0 1 1 1 0 Thioredoxin-like domain GST_N_2 PF13409.1 KOH00634.1 - 0.078 12.9 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Thioredoxin_4 PF13462.1 KOH00634.1 - 0.17 11.9 0.6 3.1 7.7 0.0 2.0 1 1 1 2 2 2 0 Thioredoxin GAT PF03127.9 KOH00635.1 - 3.3e-06 27.0 0.1 7.7e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 GAT domain VHS PF00790.14 KOH00635.1 - 0.0028 17.2 0.0 0.005 16.4 0.0 1.4 1 0 0 1 1 1 1 VHS domain SelR PF01641.13 KOH00636.1 - 2.2e-50 169.4 0.0 2.8e-50 169.1 0.0 1.1 1 0 0 1 1 1 1 SelR domain GFA PF04828.9 KOH00636.1 - 0.15 12.0 1.7 1.1 9.2 0.1 2.4 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.2 KOH00636.1 - 0.22 11.3 4.4 1.1 9.1 0.2 2.2 1 1 1 2 2 2 0 Double zinc ribbon Yippee-Mis18 PF03226.9 KOH00636.1 - 0.47 10.5 2.6 3.3 7.8 1.8 2.1 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-Mss51 PF13824.1 KOH00636.1 - 1.3 8.8 6.6 21 5.0 0.1 3.3 1 1 2 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Ste50p-SAM PF09235.5 KOH00637.1 - 1.2e-36 124.5 6.3 2.2e-36 123.6 4.4 1.4 1 0 0 1 1 1 1 Ste50p, sterile alpha motif RA PF00788.18 KOH00637.1 - 1.6e-15 57.3 0.0 3.8e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain DUF2828 PF11443.3 KOH00637.1 - 0.012 13.9 0.1 0.014 13.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF342 PF03961.8 KOH00637.1 - 0.16 10.3 0.6 0.27 9.6 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) RRP7 PF12923.2 KOH00638.1 - 1e-34 119.4 8.9 2e-34 118.3 6.2 1.6 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) Ribosomal_L14e PF01929.12 KOH00638.1 - 6.8 7.1 12.3 12 6.3 2.6 3.3 2 1 1 3 3 3 0 Ribosomal protein L14 Histidinol_dh PF00815.15 KOH00639.1 - 3.4e-186 618.8 0.9 4.9e-186 618.3 0.6 1.2 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.13 KOH00639.1 - 2.5e-28 97.4 0.0 4.8e-28 96.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.12 KOH00639.1 - 1.5e-10 41.1 0.1 6.6e-10 39.1 0.1 2.2 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase ATP-cone PF03477.11 KOH00639.1 - 0.012 16.0 0.4 0.11 12.9 0.1 2.7 2 0 0 2 2 2 0 ATP cone domain ACPS PF01648.15 KOH00639.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 4'-phosphopantetheinyl transferase superfamily CAP_GLY PF01302.20 KOH00640.1 - 8.5e-16 57.4 0.0 1.5e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain zf-CCHC_4 PF14392.1 KOH00640.1 - 0.034 13.8 1.3 0.095 12.3 0.9 1.8 1 0 0 1 1 1 0 Zinc knuckle PspA_IM30 PF04012.7 KOH00640.1 - 0.99 8.7 25.9 0.32 10.3 11.4 2.2 1 1 0 2 2 2 0 PspA/IM30 family Spc7 PF08317.6 KOH00640.1 - 1.6 7.2 30.9 3.8 6.0 7.0 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein ACT_5 PF13710.1 KOH00640.1 - 2.6 7.9 6.4 19 5.1 0.1 3.9 4 0 0 4 4 4 0 ACT domain DUF4239 PF14023.1 KOH00640.1 - 5.1 6.3 7.4 0.48 9.7 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) TPR_11 PF13414.1 KOH00641.1 - 0.018 14.7 0.0 0.018 14.7 0.0 2.4 3 0 0 3 3 3 0 TPR repeat TPR_2 PF07719.12 KOH00641.1 - 0.056 13.3 0.0 0.19 11.7 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOH00641.1 - 0.53 10.8 0.0 0.53 10.8 0.0 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat SH3_9 PF14604.1 KOH00642.1 - 3.3e-06 26.5 0.0 8.4e-06 25.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 KOH00642.1 - 7.3e-06 25.2 0.0 2.3e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.12 KOH00642.1 - 0.00066 19.1 0.0 0.0018 17.7 0.0 1.8 1 1 0 1 1 1 1 Variant SH3 domain SKG6 PF08693.5 KOH00642.1 - 0.0052 16.0 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF485 PF04341.7 KOH00642.1 - 0.11 12.1 0.1 0.21 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF485 Nitroreductase PF00881.19 KOH00643.1 - 1.3e-07 31.6 0.1 2.1e-07 30.8 0.0 1.4 1 1 0 1 1 1 1 Nitroreductase family AA_permease PF00324.16 KOH00644.1 - 2.8e-127 424.9 37.7 3.3e-127 424.7 26.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOH00644.1 - 3.8e-32 111.3 38.7 4.5e-32 111.1 26.8 1.0 1 0 0 1 1 1 1 Amino acid permease Pkinase PF00069.20 KOH00645.1 - 3.2e-69 232.9 0.0 7.6e-69 231.7 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00645.1 - 2.2e-34 118.7 0.0 5.4e-34 117.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH00645.1 - 4.4e-05 22.6 0.0 0.0001 21.3 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOH00645.1 - 0.031 14.0 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 KOH00645.1 - 0.066 12.2 0.0 0.14 11.1 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Rieske PF00355.21 KOH00647.1 - 0.033 13.7 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain Iso_dh PF00180.15 KOH00648.1 - 2.3e-131 437.8 0.0 2.7e-131 437.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DNA_ligase_aden PF01653.13 KOH00648.1 - 0.091 11.6 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 NAD-dependent DNA ligase adenylation domain Aminotran_5 PF00266.14 KOH00649.1 - 6.9e-103 344.2 0.0 8.7e-103 343.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 KOH00649.1 - 6e-09 35.4 0.0 8.8e-09 34.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 KOH00649.1 - 3.1e-08 32.9 0.0 6.9e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 KOH00649.1 - 1.4e-06 27.5 0.2 3.4e-06 26.3 0.1 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.14 KOH00649.1 - 0.00039 18.9 0.0 0.00065 18.2 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.15 KOH00649.1 - 0.0018 16.6 0.2 0.0029 15.9 0.1 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF2036 PF09724.4 KOH00650.1 - 1e-88 297.6 1.6 1.2e-88 297.4 1.1 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) DUF3507 PF12015.3 KOH00651.1 - 3.9e-63 212.2 0.0 7.9e-63 211.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) DUF2015 PF09435.5 KOH00652.1 - 4.6e-47 158.9 0.2 5.1e-47 158.8 0.2 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) YMF19 PF02326.10 KOH00652.1 - 0.23 12.0 1.3 0.35 11.4 0.9 1.5 1 1 0 1 1 1 0 Plant ATP synthase F0 RRM_1 PF00076.17 KOH00653.1 - 4.8e-57 189.4 0.2 1.2e-19 69.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOH00653.1 - 4.7e-35 119.4 0.1 2.9e-11 43.1 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOH00653.1 - 2.8e-17 62.2 0.1 1.5e-08 34.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1325 PF07039.6 KOH00654.1 - 1.1e-34 118.8 0.0 3e-34 117.4 0.0 1.7 2 0 0 2 2 2 1 SGF29 tudor-like domain DUF4537 PF15057.1 KOH00654.1 - 0.013 15.2 0.0 0.038 13.7 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4537) ALS_ss_C PF10369.4 KOH00655.1 - 4.1e-19 68.0 0.3 1.7e-18 66.0 0.0 2.2 3 0 0 3 3 3 1 Small subunit of acetolactate synthase ACT PF01842.20 KOH00655.1 - 9.7e-12 44.1 0.1 1.8e-11 43.2 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.1 KOH00655.1 - 6.8e-09 35.4 0.0 1.2e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 ACT domain Limkain-b1 PF11608.3 KOH00655.1 - 0.0053 16.4 0.3 0.053 13.2 0.0 2.6 3 0 0 3 3 3 1 Limkain b1 ACT_4 PF13291.1 KOH00655.1 - 0.054 13.8 0.1 0.49 10.7 0.0 2.2 2 0 0 2 2 2 0 ACT domain UEV PF05743.8 KOH00656.1 - 8.1e-30 103.0 0.0 1.5e-29 102.1 0.0 1.5 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.5 KOH00656.1 - 4.5e-26 90.2 0.9 1.6e-25 88.4 0.1 2.2 2 0 0 2 2 2 1 Vps23 core domain UQ_con PF00179.21 KOH00656.1 - 8.8e-07 28.4 0.5 2.2e-06 27.1 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme WASH_WAHD PF11945.3 KOH00656.1 - 0.007 15.7 0.6 0.0099 15.2 0.4 1.1 1 0 0 1 1 1 1 WAHD domain of WASH complex DUF3540 PF12059.3 KOH00656.1 - 0.019 14.5 2.8 0.03 13.9 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3540) DUF1342 PF07072.6 KOH00656.1 - 0.041 13.5 2.6 0.068 12.8 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1342) Peptidase_M9_N PF08453.5 KOH00656.1 - 0.15 11.4 1.2 0.23 10.7 0.8 1.3 1 1 0 1 1 1 0 Peptidase family M9 N-terminal Metal_resist PF13801.1 KOH00656.1 - 0.34 10.9 2.5 1.7 8.6 0.4 2.3 1 1 1 2 2 2 0 Heavy-metal resistance DUF605 PF04652.11 KOH00656.1 - 1.9 7.7 7.2 2.5 7.4 5.0 1.2 1 0 0 1 1 1 0 Vta1 like ATP_synt_H PF05493.8 KOH00657.1 - 6.6e-18 64.5 1.1 7e-18 64.4 0.8 1.0 1 0 0 1 1 1 1 ATP synthase subunit H AzlD PF05437.7 KOH00657.1 - 0.031 14.2 0.1 0.038 13.9 0.1 1.2 1 0 0 1 1 1 0 Branched-chain amino acid transport protein (AzlD) DUF1129 PF06570.6 KOH00657.1 - 0.15 11.3 0.5 0.15 11.3 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) PLDc_2 PF13091.1 KOH00659.1 - 1e-16 60.8 0.0 2.8e-07 30.3 0.0 2.6 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.17 KOH00659.1 - 1e-11 44.1 1.3 1.2e-06 28.0 0.1 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif PQ-loop PF04193.9 KOH00660.1 - 0.012 15.1 1.2 0.012 15.1 0.8 2.4 2 1 0 2 2 2 0 PQ loop repeat Rer1 PF03248.8 KOH00661.1 - 7.8e-77 256.8 4.9 8.9e-77 256.6 3.4 1.0 1 0 0 1 1 1 1 Rer1 family DUF4395 PF14340.1 KOH00661.1 - 0.0075 16.3 1.6 1.7 8.7 0.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4395) eRF1_2 PF03464.10 KOH00662.1 - 7.1e-33 113.7 0.2 1.6e-32 112.6 0.1 1.6 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 KOH00662.1 - 2.2e-26 92.3 0.1 5.4e-26 91.0 0.1 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.10 KOH00662.1 - 1.8e-11 43.7 0.8 3.2e-11 42.9 0.5 1.4 1 0 0 1 1 1 1 eRF1 domain 1 PhosphMutase PF10143.4 KOH00662.1 - 0.019 14.5 0.1 0.038 13.6 0.0 1.5 1 0 0 1 1 1 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase PhnI PF05861.7 KOH00662.1 - 0.027 12.9 0.1 0.43 9.0 0.0 2.1 2 0 0 2 2 2 0 Bacterial phosphonate metabolism protein (PhnI) Septin PF00735.13 KOH00663.1 - 1.2e-107 359.1 1.0 1.4e-107 358.8 0.7 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 KOH00663.1 - 1.2e-08 34.8 0.0 2.4e-08 33.9 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 KOH00663.1 - 5.1e-08 32.2 0.0 9.1e-08 31.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AIG1 PF04548.11 KOH00663.1 - 6.6e-07 28.6 0.3 2e-06 27.0 0.2 1.8 1 1 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.22 KOH00663.1 - 1.4e-06 27.9 0.5 3e-05 23.5 0.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 KOH00663.1 - 0.0002 21.1 1.2 0.064 13.0 0.4 2.5 1 1 1 2 2 2 1 Dynamin family AAA_24 PF13479.1 KOH00663.1 - 0.00031 20.3 0.1 0.0006 19.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 KOH00663.1 - 0.00032 20.2 0.0 0.00038 19.9 0.0 1.4 1 1 0 1 1 1 1 AAA-like domain FtsK_SpoIIIE PF01580.13 KOH00663.1 - 0.0004 19.9 0.1 0.0012 18.4 0.0 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family Gtr1_RagA PF04670.7 KOH00663.1 - 0.00059 19.0 0.6 0.0053 15.9 0.4 2.1 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 KOH00663.1 - 0.0032 17.9 0.2 0.0074 16.7 0.1 1.9 1 1 0 1 1 1 1 Miro-like protein AAA_16 PF13191.1 KOH00663.1 - 0.0033 17.4 0.2 0.008 16.1 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.22 KOH00663.1 - 0.0049 17.1 1.1 0.015 15.5 0.4 2.1 2 1 0 2 2 2 1 ABC transporter IIGP PF05049.8 KOH00663.1 - 0.0067 15.2 0.4 0.017 13.9 0.1 1.7 1 1 1 2 2 2 1 Interferon-inducible GTPase (IIGP) AAA_22 PF13401.1 KOH00663.1 - 0.0074 16.4 0.1 0.016 15.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.17 KOH00663.1 - 0.0079 15.0 0.2 0.011 14.6 0.1 1.4 1 1 0 1 1 1 1 NB-ARC domain FeoB_N PF02421.13 KOH00663.1 - 0.014 14.7 1.2 0.84 8.9 0.1 2.4 1 1 0 2 2 2 0 Ferrous iron transport protein B AAA_29 PF13555.1 KOH00663.1 - 0.016 14.7 0.0 0.036 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.1 KOH00663.1 - 0.016 15.0 0.2 0.078 12.8 0.0 2.2 2 2 0 2 2 2 0 AAA domain AAA_23 PF13476.1 KOH00663.1 - 0.016 15.5 0.2 0.031 14.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 KOH00663.1 - 0.021 14.5 0.2 0.15 11.8 0.1 2.3 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.4 KOH00663.1 - 0.034 13.6 0.2 0.73 9.3 0.1 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation T2SE PF00437.15 KOH00663.1 - 0.045 12.6 0.1 0.088 11.6 0.1 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.1 KOH00663.1 - 0.074 12.9 0.2 0.21 11.4 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KOH00663.1 - 0.084 13.6 0.5 0.26 12.1 0.3 2.1 1 1 0 1 1 1 0 AAA domain Ribosomal_L32p PF01783.18 KOH00664.1 - 7.6e-10 38.8 5.9 1.3e-09 38.1 4.1 1.4 1 0 0 1 1 1 1 Ribosomal L32p protein family CpXC PF14353.1 KOH00664.1 - 0.054 13.4 0.9 0.077 12.9 0.7 1.3 1 0 0 1 1 1 0 CpXC protein FMN_red PF03358.10 KOH00665.1 - 2.8e-08 33.4 0.0 4.3e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.20 KOH00665.1 - 3.7e-08 33.4 0.0 6e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_2 PF02525.12 KOH00665.1 - 1.7e-05 24.4 0.0 3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold Citrate_synt PF00285.16 KOH00666.1 - 1.2e-102 343.2 0.0 1.5e-102 342.9 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase DUF1129 PF06570.6 KOH00667.1 - 0.043 13.1 2.6 0.064 12.5 1.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) DUF4131 PF13567.1 KOH00667.1 - 1.7 8.0 8.7 3 7.1 5.6 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF805 PF05656.9 KOH00667.1 - 6.4 6.6 8.8 9.6 6.0 2.9 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF805) Pkinase PF00069.20 KOH00668.1 - 7.7e-67 225.1 0.0 1.1e-66 224.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00668.1 - 1.1e-26 93.5 0.0 1.7e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH00668.1 - 0.0024 16.8 0.0 0.0047 15.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOH00668.1 - 0.024 14.3 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 KOH00668.1 - 0.055 12.5 0.0 0.097 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 KOH00668.1 - 0.06 12.9 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.17 KOH00668.1 - 0.098 11.9 0.2 0.48 9.7 0.0 2.1 2 0 0 2 2 2 0 RIO1 family MBD_C PF14048.1 KOH00668.1 - 2.6 8.6 4.8 1.8 9.1 0.3 2.8 1 1 2 3 3 3 0 C-terminal domain of methyl-CpG binding protein 2 and 3 BAR PF03114.13 KOH00669.1 - 3.3e-55 187.1 1.6 3.9e-55 186.8 1.1 1.1 1 0 0 1 1 1 1 BAR domain DUF1496 PF07383.7 KOH00669.1 - 0.0013 17.8 0.5 0.0025 17.0 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1496) Seryl_tRNA_N PF02403.17 KOH00669.1 - 0.039 13.9 4.0 1.2 9.1 0.8 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF2458 PF10454.4 KOH00669.1 - 0.29 11.0 3.6 0.14 12.0 0.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2458) DUF4164 PF13747.1 KOH00669.1 - 0.35 11.0 3.4 0.55 10.4 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Grp1_Fun34_YaaH PF01184.14 KOH00670.1 - 8.6e-94 312.7 17.6 1e-93 312.5 12.2 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF373 PF04123.8 KOH00670.1 - 0.84 8.5 5.1 0.49 9.3 2.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF373) DUF997 PF06196.7 KOH00670.1 - 0.97 8.9 5.8 6.4 6.3 1.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF997) ABC2_membrane PF01061.19 KOH00671.1 - 5.4e-37 126.9 21.1 5.4e-37 126.9 14.6 2.0 3 0 0 3 3 2 1 ABC-2 type transporter ABC_tran PF00005.22 KOH00671.1 - 2.1e-29 102.5 0.1 5.5e-29 101.2 0.0 1.8 2 0 0 2 2 2 1 ABC transporter DUF258 PF03193.11 KOH00671.1 - 3.2e-05 23.1 0.2 7.5e-05 21.9 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 KOH00671.1 - 0.001 19.1 0.0 0.0024 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 KOH00671.1 - 0.0017 17.8 0.0 0.032 13.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.1 KOH00671.1 - 0.0051 15.8 3.0 0.73 8.8 0.0 3.1 3 1 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.1 KOH00671.1 - 0.012 15.1 0.1 0.029 13.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.1 KOH00671.1 - 0.03 14.4 0.2 0.087 12.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KOH00671.1 - 0.045 13.7 0.4 0.079 12.9 0.3 1.3 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 KOH00671.1 - 0.1 12.5 0.1 0.35 10.8 0.0 2.0 2 1 0 2 2 1 0 Putative exonuclease SbcCD, C subunit AAA_17 PF13207.1 KOH00671.1 - 0.12 13.1 0.3 0.51 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 KOH00671.1 - 0.15 11.6 0.6 0.27 10.8 0.4 1.4 1 0 0 1 1 1 0 NACHT domain Laminin_EGF PF00053.19 KOH00671.1 - 0.2 11.6 32.5 0.027 14.3 3.7 4.1 4 0 0 4 4 4 0 Laminin EGF-like (Domains III and V) EGF_2 PF07974.8 KOH00671.1 - 0.7 10.1 27.3 0.05 13.7 4.3 4.0 4 0 0 4 4 3 0 EGF-like domain PGK PF00162.14 KOH00672.1 - 7.6e-153 508.6 0.1 8.6e-153 508.4 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DNA_pol_B_thumb PF14791.1 KOH00673.1 - 5.1e-17 61.3 0.0 1.5e-16 59.7 0.0 1.9 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_8 PF14716.1 KOH00673.1 - 1.1e-15 57.5 0.1 3.9e-15 55.7 0.1 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_palm PF14792.1 KOH00673.1 - 3.7e-12 46.2 0.0 1.5e-11 44.3 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.4 KOH00673.1 - 0.0027 17.2 0.1 0.02 14.4 0.1 2.5 1 1 0 1 1 1 1 Fingers domain of DNA polymerase lambda HAD PF12710.2 KOH00674.1 - 3.9e-09 36.9 0.0 6.3e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2373 PF10180.4 KOH00675.1 - 3.7e-29 100.0 1.1 8.3e-29 98.9 0.8 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) DUF4120 PF13496.1 KOH00675.1 - 0.17 11.9 2.4 1.7 8.6 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4120) Frag1 PF10277.4 KOH00676.1 - 1.3e-36 126.0 10.3 1.3e-36 126.0 7.1 3.5 3 2 0 3 3 3 1 Frag1/DRAM/Sfk1 family PfkB PF00294.19 KOH00677.1 - 1e-10 41.2 0.0 1.5e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase TENA_THI-4 PF03070.11 KOH00678.1 - 3e-12 46.7 0.4 4.4e-12 46.1 0.3 1.3 1 0 0 1 1 1 1 TENA/THI-4/PQQC family LSM PF01423.17 KOH00679.1 - 1.4e-11 43.7 0.1 1.8e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain Bac_rhodopsin PF01036.13 KOH00681.1 - 6.6e-58 195.6 18.2 8.1e-58 195.3 12.6 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF4131 PF13567.1 KOH00681.1 - 0.0016 17.8 9.5 0.055 12.8 1.2 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4131) MFS_1 PF07690.11 KOH00682.1 - 9.8e-32 110.0 1.2 2.3e-31 108.7 0.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOH00682.1 - 4.7e-10 38.6 4.8 4.7e-10 38.6 3.3 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.1 KOH00682.1 - 0.00016 20.2 4.7 0.00016 20.2 3.2 2.5 2 0 0 2 2 2 2 MFS/sugar transport protein tRNA-synt_2 PF00152.15 KOH00683.1 - 1.7e-73 247.3 0.0 2.3e-73 246.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KOH00683.1 - 2.8e-08 33.5 0.0 4.8e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain PMP1_2 PF08114.6 KOH00684.1 - 4e-27 93.4 4.1 4.3e-27 93.3 2.8 1.0 1 0 0 1 1 1 1 ATPase proteolipid family DUF1049 PF06305.6 KOH00684.1 - 0.026 14.0 0.9 0.032 13.6 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Vpu PF00558.14 KOH00684.1 - 0.058 12.9 0.6 0.058 12.9 0.4 1.0 1 0 0 1 1 1 0 Vpu protein Chordopox_A13L PF05961.6 KOH00684.1 - 0.075 12.9 1.0 0.086 12.7 0.7 1.1 1 0 0 1 1 1 0 Chordopoxvirus A13L protein DUF1443 PF07280.6 KOH00684.1 - 0.1 12.2 1.4 0.13 11.8 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1443) TrbE PF11100.3 KOH00684.1 - 0.11 12.4 0.4 0.12 12.2 0.2 1.1 1 0 0 1 1 1 0 Conjugal transfer protein TrbE Sigma_reg_N PF13800.1 KOH00684.1 - 0.12 12.3 0.2 0.13 12.2 0.1 1.1 1 0 0 1 1 1 0 Sigma factor regulator N-terminal RCR PF12273.3 KOH00684.1 - 0.22 12.0 1.3 0.25 11.9 0.9 1.0 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Phosphodiest PF01663.17 KOH00685.1 - 2.9e-84 283.5 4.4 2.9e-84 283.5 3.1 1.4 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 KOH00685.1 - 0.00022 20.5 0.0 0.0011 18.1 0.0 2.1 1 1 0 1 1 1 1 Sulfatase Nop14 PF04147.7 KOH00685.1 - 0.0041 15.1 4.5 0.0067 14.4 3.1 1.3 1 0 0 1 1 1 1 Nop14-like family Sigma70_ner PF04546.8 KOH00685.1 - 0.28 10.7 7.2 0.7 9.4 5.0 1.7 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2457 PF10446.4 KOH00685.1 - 0.31 9.7 16.4 0.53 8.9 11.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sporozoite_P67 PF05642.6 KOH00685.1 - 0.45 8.3 7.3 0.82 7.4 5.0 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Cwf_Cwc_15 PF04889.7 KOH00685.1 - 1 9.0 9.6 2 8.0 6.6 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.9 KOH00685.1 - 1.1 7.2 4.9 1.6 6.6 3.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Nucleoplasmin PF03066.10 KOH00685.1 - 2.8 7.4 9.3 7.2 6.1 6.4 1.8 1 0 0 1 1 1 0 Nucleoplasmin NOA36 PF06524.7 KOH00685.1 - 9.2 5.4 12.1 15 4.7 8.4 1.2 1 0 0 1 1 1 0 NOA36 protein Ras PF00071.17 KOH00686.1 - 9.7e-47 158.3 0.1 1.1e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOH00686.1 - 2.2e-11 44.2 0.0 4e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOH00686.1 - 5.4e-08 32.2 0.0 6.4e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOH00686.1 - 1.4e-05 25.0 0.0 1.9e-05 24.5 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOH00686.1 - 0.00034 20.1 0.2 0.012 15.1 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_14 PF13173.1 KOH00686.1 - 0.0018 18.1 0.1 0.014 15.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain SRPRB PF09439.5 KOH00686.1 - 0.0033 16.6 0.1 0.0046 16.1 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arch_ATPase PF01637.13 KOH00686.1 - 0.0085 15.8 1.3 0.08 12.6 0.9 2.0 1 1 0 1 1 1 1 Archaeal ATPase FeoB_N PF02421.13 KOH00686.1 - 0.032 13.5 0.0 0.052 12.8 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_28 PF13521.1 KOH00686.1 - 0.075 12.9 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.11 KOH00687.1 - 3.8e-21 75.1 28.2 5.6e-21 74.6 19.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DDDD PF10161.4 KOH00687.1 - 1.5e-05 24.5 1.0 4.1e-05 23.1 0.2 2.1 2 0 0 2 2 2 1 Putative mitochondrial precursor protein muHD PF10291.4 KOH00688.1 - 5.1e-77 258.5 0.0 1.1e-76 257.4 0.0 1.6 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.18 KOH00688.1 - 0.016 15.4 2.3 0.066 13.3 1.6 2.2 1 1 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain Ribosomal_S11 PF00411.14 KOH00689.1 - 4.9e-40 136.1 1.0 5.8e-40 135.8 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Beach PF02138.13 KOH00690.1 - 4.8e-107 357.4 1.8 2.3e-106 355.1 0.0 2.4 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.1 KOH00690.1 - 7.3e-12 45.0 4.4 8.4e-11 41.6 0.0 2.9 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.1 KOH00690.1 - 0.0036 17.5 0.0 0.0076 16.4 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Myb_DNA-binding PF00249.26 KOH00691.1 - 3.5e-16 58.9 0.1 1.1e-06 28.6 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOH00691.1 - 2.8e-05 24.1 0.2 0.0095 16.0 0.1 3.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain ELO PF01151.13 KOH00692.1 - 9.5e-61 205.2 25.7 1.1e-60 205.0 17.8 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family RNase_PH PF01138.16 KOH00693.1 - 3.8e-27 95.1 3.7 1.9e-26 92.9 0.9 2.7 3 1 0 3 3 3 1 3' exoribonuclease family, domain 1 PfkB PF00294.19 KOH00694.1 - 9.7e-44 149.6 1.9 3.2e-43 148.0 1.3 1.7 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 KOH00694.1 - 0.037 13.2 0.0 1.7 7.7 0.0 2.4 2 0 0 2 2 2 0 Phosphomethylpyrimidine kinase RasGEF PF00617.14 KOH00695.1 - 3.5e-28 98.5 1.4 3.5e-28 98.5 1.0 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 KOH00695.1 - 0.0028 17.7 1.1 0.0028 17.7 0.8 2.5 3 0 0 3 3 3 1 RasGEF N-terminal motif BCAS2 PF05700.6 KOH00695.1 - 0.014 14.8 0.2 0.031 13.7 0.2 1.5 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) Glycoprotein_G PF00802.14 KOH00695.1 - 0.13 11.3 4.6 0.54 9.3 0.4 2.3 2 0 0 2 2 2 0 Pneumovirus attachment glycoprotein G Homeobox PF00046.24 KOH00696.1 - 5e-09 35.6 1.2 5e-09 35.6 0.8 1.7 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.6 KOH00696.1 - 7.1e-07 28.8 0.4 7.1e-07 28.8 0.3 2.2 3 0 0 3 3 3 1 Homeobox KN domain Homez PF11569.3 KOH00696.1 - 0.0076 15.2 0.2 0.058 12.4 0.0 2.1 1 1 1 2 2 2 1 Homeodomain leucine-zipper encoding, Homez Syntaxin-6_N PF09177.6 KOH00696.1 - 0.028 14.7 2.8 0.11 12.9 2.0 2.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Aurora-A_bind PF09041.5 KOH00696.1 - 0.069 12.9 0.1 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Aurora-A binding MAT_Alpha1 PF04769.7 KOH00697.1 - 2.3e-30 105.4 0.7 2.6e-30 105.2 0.5 1.0 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 Peptidase_M1 PF01433.15 KOH00698.1 - 2.4e-06 26.9 1.4 0.15 11.1 0.0 3.4 2 1 1 3 3 3 3 Peptidase family M1 CDC45 PF02724.9 KOH00698.1 - 0.17 9.8 11.0 0.27 9.2 7.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.7 KOH00698.1 - 0.48 8.2 22.2 0.77 7.5 15.4 1.2 1 0 0 1 1 1 0 Nop14-like family Per1 PF04080.8 KOH00700.1 - 5.6e-99 330.9 17.5 5.6e-99 330.9 12.1 1.4 2 0 0 2 2 2 1 Per1-like Peptidase_S8 PF00082.17 KOH00701.1 - 7.2e-45 153.3 0.1 1e-44 152.8 0.0 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 KOH00701.1 - 2.6e-06 27.9 0.0 5.5e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 Ribosomal_L19 PF01245.15 KOH00702.1 - 3.1e-11 43.0 0.0 4.4e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L19 Img2 PF05046.9 KOH00702.1 - 0.13 12.4 0.6 0.4 10.9 0.1 1.9 2 0 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) WBS_methylT PF12589.3 KOH00703.1 - 2.2e-17 63.3 5.4 2.2e-17 63.3 3.8 1.8 2 0 0 2 2 2 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.7 KOH00703.1 - 4e-13 49.6 0.0 9.5e-13 48.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOH00703.1 - 5.4e-07 30.0 0.0 2.9e-06 27.6 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOH00703.1 - 1e-06 28.9 0.0 4.6e-06 26.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOH00703.1 - 7.3e-06 25.7 0.0 1.2e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOH00703.1 - 1.4e-05 24.6 0.0 6.3e-05 22.5 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain CMAS PF02353.15 KOH00703.1 - 2e-05 23.8 0.1 0.00019 20.5 0.0 2.3 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.2 KOH00703.1 - 4.4e-05 24.0 0.0 0.00019 21.9 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.14 KOH00703.1 - 0.00031 20.3 0.0 0.00073 19.1 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 KOH00703.1 - 0.00039 20.4 0.0 0.0011 18.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 KOH00703.1 - 0.0011 18.4 0.0 0.0019 17.5 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.8 KOH00703.1 - 0.0049 16.0 0.3 0.017 14.2 0.0 1.9 3 0 0 3 3 3 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.1 KOH00703.1 - 0.033 13.8 0.1 1.4 8.5 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain AdoMet_MTase PF07757.8 KOH00703.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase MBOAT PF03062.14 KOH00704.1 - 2.2e-67 227.4 42.6 2.2e-67 227.4 29.6 1.4 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Ank_5 PF13857.1 KOH00705.1 - 1.4e-15 56.8 0.6 1.1e-11 44.5 0.2 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOH00705.1 - 7.3e-10 39.0 0.1 1.1e-08 35.2 0.0 2.2 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOH00705.1 - 8.7e-10 38.8 0.4 7.9e-05 23.0 0.2 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOH00705.1 - 3.3e-07 29.9 0.1 0.00026 20.9 0.1 3.6 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.25 KOH00705.1 - 5.8e-07 28.9 5.5 1.2e-05 24.8 0.3 3.3 4 0 0 4 4 4 2 Ankyrin repeat Inositol_P PF00459.20 KOH00705.1 - 0.0059 15.9 0.0 0.01 15.1 0.0 1.4 1 0 0 1 1 1 1 Inositol monophosphatase family SWIB PF02201.13 KOH00706.1 - 0.0057 16.3 0.0 0.017 14.8 0.0 1.8 1 0 0 1 1 1 1 SWIB/MDM2 domain RNase_H2_suC PF08615.6 KOH00706.1 - 0.33 10.7 3.7 3.3 7.5 0.3 2.7 2 1 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) TT_ORF2 PF02957.10 KOH00706.1 - 2.8 8.6 7.3 22 5.7 0.1 2.7 2 0 0 2 2 2 0 TT viral ORF2 DUF4611 PF15387.1 KOH00706.1 - 3.9 7.6 16.7 2.4 8.3 1.9 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) Senescence_reg PF04520.8 KOH00706.1 - 7.9 6.9 8.0 0.55 10.7 0.1 2.6 3 0 0 3 3 3 0 Senescence regulator Thr_synth_N PF14821.1 KOH00707.1 - 3.8e-28 97.3 0.0 1.3e-27 95.6 0.0 2.0 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.20 KOH00707.1 - 7.1e-20 71.4 0.0 1.2e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Atx10homo_assoc PF09759.4 KOH00708.1 - 4.3e-38 129.1 1.5 7.9e-38 128.2 0.2 2.1 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain DUF2454 PF10521.4 KOH00708.1 - 0.024 13.6 1.1 1.7 7.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2454) Cut8_M PF14483.1 KOH00708.1 - 0.094 12.5 0.0 0.5 10.1 0.0 2.3 1 0 0 1 1 1 0 Cut8 dimerisation domain WD40 PF00400.27 KOH00709.1 - 2e-63 208.1 14.8 8e-13 47.7 0.1 12.8 13 0 0 13 13 13 8 WD domain, G-beta repeat Utp12 PF04003.7 KOH00709.1 - 2.8e-26 91.5 0.0 4.6e-26 90.8 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family eIF2A PF08662.6 KOH00709.1 - 5.7e-11 42.4 6.2 0.00046 19.9 0.0 6.7 4 3 3 8 8 8 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 KOH00709.1 - 2.8e-06 26.6 0.7 0.055 12.5 0.0 3.9 3 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.3 KOH00709.1 - 5.2e-05 21.5 5.9 0.13 10.3 0.0 4.5 2 2 1 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 KOH00709.1 - 0.00014 20.3 0.7 0.18 10.0 0.0 4.2 3 1 1 5 5 5 1 Cytochrome D1 heme domain PD40 PF07676.7 KOH00709.1 - 0.013 15.1 0.2 61 3.4 0.1 4.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Apc4_WD40 PF12894.2 KOH00709.1 - 0.025 14.1 0.0 6.4 6.3 0.0 3.9 5 0 0 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain CPSF_A PF03178.10 KOH00709.1 - 0.025 13.6 0.5 0.18 10.8 0.0 2.6 3 1 0 3 3 3 0 CPSF A subunit region Proteasome_A_N PF10584.4 KOH00709.1 - 0.99 8.7 4.8 1.8 7.9 0.0 3.6 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature UPF0029 PF01205.14 KOH00710.1 - 1.1e-29 102.2 0.1 1.6e-29 101.7 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.17 KOH00710.1 - 3.3e-11 43.0 0.0 5.5e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 RWD domain TPR_11 PF13414.1 KOH00711.1 - 6.1e-19 67.4 4.7 2.2e-15 56.0 0.2 1.7 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOH00711.1 - 6.5e-11 41.3 0.7 0.00013 21.4 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOH00711.1 - 1.8e-10 41.1 13.7 2.2e-09 37.7 0.7 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOH00711.1 - 1.6e-09 36.9 4.3 0.00031 20.4 0.2 2.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOH00711.1 - 2.9e-07 30.5 4.6 0.006 17.1 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOH00711.1 - 1.1e-06 28.8 2.8 1.1e-06 28.8 1.9 1.4 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOH00711.1 - 6.6e-06 25.5 0.2 0.068 13.0 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 KOH00711.1 - 3.1e-05 24.0 0.7 4.1e-05 23.6 0.5 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.1 KOH00711.1 - 3.6e-05 23.5 1.5 0.061 13.2 0.0 2.4 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.1 KOH00711.1 - 5.7e-05 22.8 1.1 5.7e-05 22.8 0.8 1.7 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOH00711.1 - 0.00042 20.2 0.1 0.0014 18.6 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOH00711.1 - 0.00056 20.1 3.8 0.16 12.4 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOH00711.1 - 0.0013 18.5 4.6 0.055 13.4 0.8 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_4 PF07721.9 KOH00711.1 - 0.0057 16.9 2.7 0.02 15.2 0.0 2.9 3 1 0 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOH00711.1 - 0.01 15.5 0.1 0.58 10.0 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Ytp1 PF10355.4 KOH00712.1 - 2.2e-110 368.1 13.0 3e-110 367.6 9.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 KOH00712.1 - 9.9e-27 92.5 2.9 9.9e-27 92.5 2.0 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) DUF3246 PF11596.3 KOH00712.1 - 0.15 11.3 1.1 0.28 10.4 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) G10 PF01125.12 KOH00714.1 - 3.9e-61 204.8 7.2 4.4e-61 204.6 5.0 1.0 1 0 0 1 1 1 1 G10 protein DNase_II PF03265.10 KOH00714.1 - 0.026 13.5 0.6 0.034 13.1 0.4 1.2 1 1 0 1 1 1 0 Deoxyribonuclease II Fork_head PF00250.13 KOH00715.1 - 1.1e-36 124.6 0.2 3.1e-36 123.2 0.2 1.8 1 0 0 1 1 1 1 Fork head domain zf-C3HC4 PF00097.20 KOH00716.1 - 1.4e-10 40.6 12.9 1.4e-10 40.6 8.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOH00716.1 - 2.6e-08 33.7 12.8 2.6e-08 33.7 8.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOH00716.1 - 1.4e-07 31.1 16.3 4.5e-07 29.5 8.1 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOH00716.1 - 8.2e-07 28.6 12.9 3.1e-06 26.7 5.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOH00716.1 - 2.6e-06 27.0 17.9 1.6e-05 24.5 7.6 2.4 2 0 0 2 2 2 2 zinc-RING finger domain SAP PF02037.22 KOH00716.1 - 4.3e-06 26.0 0.0 1.3e-05 24.5 0.0 1.9 1 0 0 1 1 1 1 SAP domain zf-RING_6 PF14835.1 KOH00716.1 - 4.5e-06 26.3 3.9 4.5e-06 26.3 2.7 1.8 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.1 KOH00716.1 - 7.7e-06 25.6 16.3 1.1e-05 25.1 8.5 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING U-box PF04564.10 KOH00716.1 - 0.0002 21.2 0.0 0.0016 18.3 0.0 2.4 2 0 0 2 2 2 1 U-box domain zf-RING_UBOX PF13445.1 KOH00716.1 - 0.00097 18.8 10.5 0.00097 18.8 7.3 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.2 KOH00716.1 - 0.0029 17.6 8.2 0.0048 16.9 3.5 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger GAGA PF09237.6 KOH00716.1 - 0.031 13.8 0.8 0.031 13.8 0.5 2.4 2 0 0 2 2 2 0 GAGA factor zf-RING_4 PF14570.1 KOH00716.1 - 0.17 11.5 8.7 0.25 10.9 1.8 2.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 KOH00716.1 - 2.2 8.1 6.3 9.6 6.1 1.8 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.1 KOH00716.1 - 3.7 7.1 9.5 2.4 7.7 3.7 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 WD40 PF00400.27 KOH00718.1 - 1.7e-09 37.1 0.1 3.8e-05 23.4 0.0 4.6 6 0 0 6 6 6 2 WD domain, G-beta repeat Lipase_3 PF01764.20 KOH00719.1 - 1.8e-09 37.3 0.0 3.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) UPF0227 PF05728.7 KOH00719.1 - 0.024 14.3 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Abhydrolase_6 PF12697.2 KOH00719.1 - 0.038 13.8 0.0 0.094 12.5 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOH00719.1 - 0.061 13.0 0.0 0.23 11.2 0.0 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family Pro_isomerase PF00160.16 KOH00720.1 - 1.3e-21 77.4 0.1 2.2e-21 76.7 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Img2 PF05046.9 KOH00721.1 - 1.5e-28 98.8 0.5 1.9e-28 98.4 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) SUI1 PF01253.17 KOH00721.1 - 0.018 14.8 0.9 0.13 12.0 0.6 2.0 1 1 0 1 1 1 0 Translation initiation factor SUI1 DUF3294 PF07957.6 KOH00721.1 - 0.054 13.0 0.0 0.073 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3294) WD40 PF00400.27 KOH00722.1 - 3.4e-86 280.3 34.0 2.1e-15 55.9 0.1 8.4 8 0 0 8 8 8 8 WD domain, G-beta repeat eIF2A PF08662.6 KOH00722.1 - 1.3e-09 38.0 1.7 4.5e-05 23.2 0.0 3.8 2 2 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 KOH00722.1 - 1.3e-06 26.8 10.8 0.13 10.3 0.4 5.5 2 1 2 5 5 5 3 Nucleoporin Nup120/160 NLE PF08154.7 KOH00722.1 - 1.8e-06 27.8 0.0 3.3e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Cytochrom_D1 PF02239.11 KOH00722.1 - 0.00062 18.1 0.0 0.078 11.2 0.0 2.9 2 1 0 2 2 2 1 Cytochrome D1 heme domain Nbas_N PF15492.1 KOH00722.1 - 0.001 18.2 1.0 0.69 8.9 0.1 3.2 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.7 KOH00722.1 - 0.0079 15.8 0.1 2.6 7.7 0.0 2.9 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Gmad1 PF10647.4 KOH00722.1 - 0.014 14.7 0.1 0.087 12.2 0.0 2.0 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain Pkinase PF00069.20 KOH00723.1 - 2.1e-63 213.9 0.0 3.3e-63 213.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00723.1 - 2.8e-34 118.3 0.1 1.5e-33 115.9 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH00723.1 - 2.7e-07 29.8 0.1 3.3e-05 23.0 0.0 2.6 2 1 0 2 2 2 2 Kinase-like APH PF01636.18 KOH00723.1 - 0.015 15.0 0.0 0.06 13.0 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Glucosamine_iso PF01182.15 KOH00724.1 - 6.2e-48 163.1 0.0 1e-47 162.4 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF3215 PF11503.3 KOH00725.1 - 2.1e-28 97.7 0.1 2.2e-28 97.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3215) PAD_M PF08527.5 KOH00725.1 - 0.093 12.1 0.0 0.096 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain PI31_Prot_C PF08577.6 KOH00726.1 - 8e-13 48.8 10.1 8e-13 48.8 7.0 2.1 2 0 0 2 2 2 1 PI31 proteasome regulator PP2C PF00481.16 KOH00727.1 - 4.9e-42 144.0 0.0 1.2e-41 142.7 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOH00727.1 - 1.2e-06 28.1 0.0 0.00011 21.7 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C Med12 PF09497.5 KOH00728.1 - 3.7e-21 74.8 0.1 9.3e-21 73.5 0.1 1.8 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 NDUFB10 PF10249.4 KOH00728.1 - 0.026 14.6 0.1 0.026 14.6 0.1 2.5 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase subunit 10 Thioredoxin PF00085.15 KOH00730.1 - 1.2e-28 98.8 0.2 1.4e-28 98.6 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 KOH00730.1 - 7.3e-08 32.5 0.7 4.1e-07 30.1 0.5 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOH00730.1 - 1.8e-06 27.9 0.0 4.6e-05 23.4 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.16 KOH00730.1 - 0.00014 21.5 0.0 0.00018 21.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_9 PF14595.1 KOH00730.1 - 0.00062 19.3 0.0 0.00074 19.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.5 KOH00730.1 - 0.0012 18.4 0.1 0.0081 15.7 0.1 1.9 1 1 1 2 2 2 1 Redoxin Thioredoxin_7 PF13899.1 KOH00730.1 - 0.0066 16.4 0.1 0.0094 15.9 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin-like DSBA PF01323.15 KOH00730.1 - 0.0079 15.7 0.2 0.15 11.6 0.1 2.1 1 1 1 2 2 2 1 DSBA-like thioredoxin domain Phosducin PF02114.11 KOH00730.1 - 0.018 13.7 0.0 0.021 13.5 0.0 1.1 1 0 0 1 1 1 0 Phosducin WD40 PF00400.27 KOH00731.1 - 1.2e-62 205.7 13.8 3.4e-10 39.3 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.5 KOH00731.1 - 3.6e-30 103.9 12.8 3.6e-30 103.9 8.9 2.6 2 0 0 2 2 2 1 Tup N-terminal PAT1 PF09770.4 KOH00731.1 - 2.9 6.0 45.9 3.9 5.5 31.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Csm1 PF12539.3 KOH00732.1 - 1.5e-29 102.2 0.9 2.4e-29 101.6 0.1 1.7 2 0 0 2 2 1 1 Chromosome segregation protein Csm1/Pcs1 ATG16 PF08614.6 KOH00732.1 - 0.00013 21.8 4.4 0.00022 21.1 3.1 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) ADIP PF11559.3 KOH00732.1 - 0.0004 20.3 1.4 0.00084 19.2 1.0 1.5 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Spc24 PF08286.6 KOH00732.1 - 0.0013 18.4 2.5 0.0013 18.4 1.7 1.7 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 Cep57_MT_bd PF06657.8 KOH00732.1 - 0.0041 17.0 2.0 1.9 8.4 0.5 2.4 2 0 0 2 2 2 1 Centrosome microtubule-binding domain of Cep57 DUF3373 PF11853.3 KOH00732.1 - 0.0042 15.6 0.4 0.0043 15.6 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3373) Syntaxin-6_N PF09177.6 KOH00732.1 - 0.0043 17.4 3.0 0.0043 17.4 2.1 1.9 2 1 0 2 2 2 1 Syntaxin 6, N-terminal BRE1 PF08647.6 KOH00732.1 - 0.0045 16.9 2.9 0.0045 16.9 2.0 1.7 2 0 0 2 2 1 1 BRE1 E3 ubiquitin ligase Rab5-bind PF09311.6 KOH00732.1 - 0.0047 16.8 2.5 0.0077 16.1 1.7 1.3 1 0 0 1 1 1 1 Rabaptin-like protein FlxA PF14282.1 KOH00732.1 - 0.0055 16.6 6.7 0.015 15.2 4.7 1.7 1 0 0 1 1 1 1 FlxA-like protein Tmemb_cc2 PF10267.4 KOH00732.1 - 0.0058 15.2 1.0 0.0058 15.2 0.7 1.8 1 1 1 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein Phage_GP20 PF06810.6 KOH00732.1 - 0.0061 16.0 6.8 0.015 14.7 4.7 1.8 1 1 0 1 1 1 1 Phage minor structural protein GP20 Fib_alpha PF08702.5 KOH00732.1 - 0.0072 16.4 3.6 0.0072 16.4 2.5 1.8 2 0 0 2 2 2 1 Fibrinogen alpha/beta chain family DUF3138 PF11336.3 KOH00732.1 - 0.0098 14.1 0.3 0.013 13.6 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3138) GAS PF13851.1 KOH00732.1 - 0.013 14.6 4.1 0.013 14.6 2.8 1.7 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding NPV_P10 PF05531.7 KOH00732.1 - 0.013 15.7 5.4 0.37 11.0 3.9 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4618 PF15397.1 KOH00732.1 - 0.014 14.7 2.5 0.014 14.7 1.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) DUF4349 PF14257.1 KOH00732.1 - 0.014 14.6 1.1 0.022 13.9 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) TMF_DNA_bd PF12329.3 KOH00732.1 - 0.02 14.6 8.3 0.02 14.6 5.7 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Occludin_ELL PF07303.8 KOH00732.1 - 0.023 15.4 1.4 0.023 15.4 0.9 1.9 2 0 0 2 2 2 0 Occludin homology domain FliD_N PF02465.13 KOH00732.1 - 0.024 14.9 0.6 0.054 13.8 0.4 1.6 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF4200 PF13863.1 KOH00732.1 - 0.026 14.4 2.5 0.026 14.4 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF3450 PF11932.3 KOH00732.1 - 0.028 13.6 1.5 0.049 12.9 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) FlgN PF05130.7 KOH00732.1 - 0.03 14.5 0.6 0.03 14.5 0.4 1.6 2 0 0 2 2 1 0 FlgN protein DUF4140 PF13600.1 KOH00732.1 - 0.037 14.4 0.4 0.16 12.4 0.3 1.9 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) SPAM PF02090.10 KOH00732.1 - 0.049 13.6 1.2 0.078 12.9 0.2 1.7 2 0 0 2 2 2 0 Salmonella surface presentation of antigen gene type M protein DUF4407 PF14362.1 KOH00732.1 - 0.05 12.5 0.9 0.07 12.0 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.7 KOH00732.1 - 0.059 13.7 2.4 0.14 12.5 1.7 1.7 1 0 0 1 1 1 0 SlyX COG2 PF06148.6 KOH00732.1 - 0.059 13.2 3.4 0.29 11.0 0.7 2.3 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Reo_sigmaC PF04582.7 KOH00732.1 - 0.083 12.0 0.6 0.11 11.6 0.4 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF4446 PF14584.1 KOH00732.1 - 0.086 12.6 1.0 0.18 11.6 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DivIC PF04977.10 KOH00732.1 - 0.094 12.2 10.2 0.035 13.6 3.2 2.7 2 1 1 3 3 3 0 Septum formation initiator Cauli_AT PF03233.8 KOH00732.1 - 0.1 12.3 4.6 0.061 13.0 1.4 1.8 2 0 0 2 2 2 0 Aphid transmission protein DUF3573 PF12097.3 KOH00732.1 - 0.13 10.8 5.3 0.15 10.5 3.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) COG5 PF10392.4 KOH00732.1 - 0.14 12.1 4.5 0.12 12.3 0.7 2.1 2 0 0 2 2 2 0 Golgi transport complex subunit 5 FlaC_arch PF05377.6 KOH00732.1 - 0.15 11.9 3.6 0.43 10.5 2.5 1.9 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) Seryl_tRNA_N PF02403.17 KOH00732.1 - 0.16 11.9 6.0 0.35 10.9 1.4 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4559 PF15112.1 KOH00732.1 - 0.24 10.5 6.4 0.11 11.6 2.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) BLOC1_2 PF10046.4 KOH00732.1 - 0.33 11.1 6.8 0.18 11.9 3.2 1.8 2 0 0 2 2 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF16 PF01519.11 KOH00732.1 - 0.35 11.0 4.6 0.28 11.4 1.8 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF16 PFEMP PF03011.10 KOH00732.1 - 0.5 10.7 7.7 0.65 10.3 2.4 2.1 2 0 0 2 2 2 0 PFEMP DBL domain TMF_TATA_bd PF12325.3 KOH00732.1 - 0.9 9.2 7.5 0.13 12.0 1.3 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF603 PF04645.7 KOH00732.1 - 1.2 9.1 6.0 1.3 8.9 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF603 IncA PF04156.9 KOH00732.1 - 2 7.9 9.2 0.13 11.8 2.5 1.7 2 0 0 2 2 2 0 IncA protein DUF4315 PF14193.1 KOH00732.1 - 4.2 7.3 9.5 0.2 11.6 2.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) zf-LYAR PF08790.6 KOH00733.1 - 1.4e-15 56.6 6.7 2.8e-15 55.6 4.6 1.5 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger zf-TRAF PF02176.13 KOH00733.1 - 0.14 12.5 2.6 0.24 11.8 1.8 1.4 1 0 0 1 1 1 0 TRAF-type zinc finger zf-C2H2_jaz PF12171.3 KOH00733.1 - 0.4 10.8 5.4 0.52 10.5 0.4 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-GRF PF06839.7 KOH00733.1 - 0.43 10.5 4.3 1.2 9.1 3.0 1.8 1 0 0 1 1 1 0 GRF zinc finger A2L_zn_ribbon PF08792.5 KOH00733.1 - 1.1 8.8 8.8 27 4.3 6.1 2.7 1 1 0 1 1 1 0 A2L zinc ribbon domain XPA_N PF01286.13 KOH00733.1 - 1.1 8.9 5.2 5.8 6.6 0.2 2.3 2 0 0 2 2 2 0 XPA protein N-terminal zf-C2H2_4 PF13894.1 KOH00733.1 - 1.3 9.5 4.2 93 3.7 2.9 2.4 1 1 0 1 1 1 0 C2H2-type zinc finger RNHCP PF12647.2 KOH00733.1 - 1.3 8.8 4.5 1.9 8.3 2.0 1.9 1 1 1 2 2 2 0 RNHCP domain MGC-24 PF05283.6 KOH00733.1 - 1.4 8.6 7.2 1.8 8.3 5.0 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) zf-met PF12874.2 KOH00733.1 - 1.5 9.1 5.3 12 6.2 0.3 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type C1_4 PF07975.7 KOH00733.1 - 1.7 8.7 7.4 1.4 9.0 3.7 2.0 1 1 0 1 1 1 0 TFIIH C1-like domain zf-C2H2 PF00096.21 KOH00733.1 - 1.7 9.1 6.3 0.79 10.1 0.6 2.5 1 1 1 2 2 2 0 Zinc finger, C2H2 type Cofilin_ADF PF00241.15 KOH00734.1 - 4e-23 81.6 0.0 8.4e-23 80.6 0.0 1.5 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_1 PF00018.23 KOH00734.1 - 2.3e-15 55.7 1.0 5.6e-15 54.4 0.7 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOH00734.1 - 1.4e-14 53.4 0.2 3.5e-14 52.1 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOH00734.1 - 2.1e-06 27.1 0.0 4.4e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Collagen PF01391.13 KOH00735.1 - 2 8.0 15.9 5.7 6.5 4.7 2.3 1 1 1 2 2 2 0 Collagen triple helix repeat (20 copies) Flocculin_t3 PF13928.1 KOH00736.1 - 1.7e-10 40.8 34.0 4.3e-07 29.9 8.4 14.4 6 3 5 11 11 11 3 Flocculin type 3 repeat DUF866 PF05907.8 KOH00737.1 - 2.2e-26 92.2 5.3 3.1e-24 85.2 3.7 2.0 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Yippee-Mis18 PF03226.9 KOH00737.1 - 0.0025 17.7 1.7 0.35 10.9 0.1 2.3 2 0 0 2 2 2 2 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF581 PF04570.9 KOH00737.1 - 0.04 13.2 0.1 0.04 13.2 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF581) EPL1 PF10513.4 KOH00737.1 - 0.074 13.2 0.1 0.098 12.9 0.0 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like zf-PHD-like PF15446.1 KOH00737.1 - 0.12 11.6 2.8 12 5.1 0.0 2.8 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain Elf1 PF05129.8 KOH00737.1 - 0.8 9.4 6.2 1 9.0 0.2 2.9 1 1 2 3 3 3 0 Transcription elongation factor Elf1 like Pkinase PF00069.20 KOH00738.1 - 9.9e-76 254.3 0.1 1.8e-75 253.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00738.1 - 4.3e-33 114.4 0.1 1.5e-32 112.6 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH00738.1 - 5.1e-12 45.3 0.1 3.3e-09 36.1 0.0 2.3 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.9 KOH00738.1 - 0.042 12.9 0.0 0.075 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MCR_beta PF02241.13 KOH00738.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain PYST-C1 PF09690.5 KOH00738.1 - 4.3 7.0 9.1 1.2 8.8 3.3 2.4 2 0 0 2 2 2 0 Plasmodium yoelii subtelomeric region (PYST-C1) MutS_V PF00488.16 KOH00739.1 - 3.8e-75 252.3 0.0 7.1e-75 251.4 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 KOH00739.1 - 9.3e-36 123.5 0.6 9.3e-36 123.5 0.4 1.7 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.15 KOH00739.1 - 6.6e-32 109.8 0.1 1.3e-31 108.9 0.0 1.5 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.13 KOH00739.1 - 3.6e-14 52.7 1.5 1e-13 51.2 1.0 1.9 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.12 KOH00739.1 - 7e-12 45.5 0.6 7.1e-11 42.3 0.0 3.1 3 2 0 3 3 3 1 MutS domain II Not1 PF04054.10 KOH00740.1 - 7.7e-138 459.4 11.9 7.7e-138 459.4 8.2 4.0 4 1 0 4 4 2 1 CCR4-Not complex component, Not1 DUF3819 PF12842.2 KOH00740.1 - 1.7e-42 144.5 5.0 1.7e-42 144.5 3.4 3.1 3 0 0 3 3 1 1 Domain of unknown function (DUF3819) PAT1 PF09770.4 KOH00740.1 - 0.00086 17.6 106.9 0.013 13.8 39.3 2.2 2 0 0 2 2 2 2 Topoisomerase II-associated protein PAT1 Gti1_Pac2 PF09729.4 KOH00740.1 - 0.0022 17.8 17.7 0.1 12.4 3.5 2.7 2 0 0 2 2 2 2 Gti1/Pac2 family zf-DHHC PF01529.15 KOH00740.1 - 0.0077 15.6 9.9 0.16 11.3 0.2 3.1 2 0 0 2 2 2 2 DHHC palmitoyltransferase TFIIA PF03153.8 KOH00740.1 - 0.016 15.1 84.6 0.037 13.9 20.4 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4557 PF15101.1 KOH00740.1 - 0.43 10.3 60.1 0.05 13.4 14.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4557) Spore_coat_CotO PF14153.1 KOH00740.1 - 0.7 9.3 50.8 0.14 11.5 11.6 2.4 2 0 0 2 2 2 0 Spore coat protein CotO GAGA_bind PF06217.7 KOH00740.1 - 1.1 9.2 36.0 0.96 9.3 8.6 2.4 2 0 0 2 2 2 0 GAGA binding protein-like family DUF966 PF06136.8 KOH00740.1 - 1.3 8.3 28.7 0.36 10.1 3.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF966) RED_N PF07808.8 KOH00740.1 - 1.7 7.8 47.6 1.6 7.8 12.5 2.9 2 0 0 2 2 2 0 RED-like protein N-terminal region DDHD PF02862.12 KOH00740.1 - 2.1 8.0 33.1 0.38 10.5 5.6 2.5 2 0 0 2 2 2 0 DDHD domain Gag_spuma PF03276.9 KOH00740.1 - 3.8 5.7 69.3 0.017 13.4 17.3 2.4 2 0 0 2 2 2 0 Spumavirus gag protein RR_TM4-6 PF06459.7 KOH00740.1 - 4.4 7.1 40.9 1.9 8.2 11.7 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF1387 PF07139.6 KOH00740.1 - 7.1 6.1 28.8 0.19 11.2 4.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) Hom_end_hint PF05203.11 KOH00740.1 - 7.6 6.1 22.7 0.73 9.5 2.2 2.4 2 0 0 2 2 2 0 Hom_end-associated Hint SPX PF03105.14 KOH00740.1 - 9.1 5.9 35.3 0.71 9.6 6.9 2.4 2 0 0 2 2 2 0 SPX domain eIF-3_zeta PF05091.7 KOH00740.1 - 10 4.6 50.9 0.55 8.7 12.1 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CDC50 PF03381.10 KOH00741.1 - 3.1e-101 338.1 1.9 4e-101 337.8 1.3 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Y_phosphatase2 PF03162.8 KOH00742.1 - 6e-45 152.5 2.4 2.3e-34 118.1 0.8 2.5 1 1 1 2 2 2 2 Tyrosine phosphatase family Transpep_BrtH PF14399.1 KOH00742.1 - 0.036 13.3 0.0 4.9 6.3 0.0 2.3 2 0 0 2 2 2 0 NlpC/p60-like transpeptidase SnAC PF14619.1 KOH00742.1 - 0.05 13.7 0.4 0.51 10.5 0.1 2.4 2 0 0 2 2 2 0 Snf2-ATP coupling, chromatin remodelling complex AFG1_ATPase PF03969.11 KOH00742.1 - 0.094 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 AFG1-like ATPase Homeobox PF00046.24 KOH00743.1 - 9.5e-10 37.9 1.2 1.5e-09 37.3 0.8 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 KOH00743.1 - 1.4e-07 31.0 0.4 2.5e-07 30.2 0.3 1.4 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.3 KOH00743.1 - 0.0019 17.2 0.3 0.023 13.7 0.0 2.2 1 1 1 2 2 2 1 Homeodomain leucine-zipper encoding, Homez DUF825 PF05695.7 KOH00743.1 - 0.014 12.8 0.7 0.015 12.7 0.5 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF825) Aurora-A_bind PF09041.5 KOH00743.1 - 0.028 14.1 0.1 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 Aurora-A binding Flocculin_t3 PF13928.1 KOH00744.1 - 0.00094 19.2 28.8 0.0022 18.0 5.8 10.5 2 1 8 10 10 10 6 Flocculin type 3 repeat Alpha-amylase PF00128.19 KOH00745.1 - 3.9e-105 351.7 0.6 5.7e-105 351.1 0.4 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.1 KOH00745.1 - 0.0057 15.6 0.2 0.018 13.9 0.1 1.7 2 0 0 2 2 2 1 glucanotransferase domain of human glycogen debranching enzyme Sugar_tr PF00083.19 KOH00746.1 - 3e-93 312.8 23.4 3.5e-93 312.6 16.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOH00746.1 - 8.6e-10 37.8 23.7 8.6e-10 37.8 16.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOH00746.1 - 2.2e-05 23.0 2.9 2.2e-05 23.0 2.0 3.3 3 1 1 4 4 4 2 MFS/sugar transport protein SNO PF01174.14 KOH00747.1 - 1.3e-16 60.7 0.1 1.4e-16 60.6 0.1 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family Cid2 PF09774.4 KOH00748.1 - 8e-37 126.6 5.3 9.6e-37 126.4 3.6 1.1 1 0 0 1 1 1 1 Caffeine-induced death protein 2 Lgl_C PF08596.5 KOH00749.1 - 6.1e-147 489.1 0.3 6.8e-146 485.7 0.1 2.3 2 1 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.27 KOH00749.1 - 0.0014 18.4 0.1 25 4.9 0.0 5.2 5 0 0 5 5 5 2 WD domain, G-beta repeat BBS2_N PF14781.1 KOH00749.1 - 0.0028 17.2 0.0 0.12 12.0 0.1 3.2 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, N-terminal Pkinase PF00069.20 KOH00750.1 - 3.3e-64 216.5 0.0 3.4e-63 213.2 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00750.1 - 1.2e-35 122.9 0.0 2.8e-35 121.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.11 KOH00750.1 - 2.7e-22 78.2 18.2 1.5e-13 50.2 5.9 3.2 4 0 0 4 4 4 2 Hr1 repeat C1_1 PF00130.17 KOH00750.1 - 3.7e-20 71.3 36.4 1.1e-10 41.0 10.4 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.19 KOH00750.1 - 1.5e-11 44.6 2.3 1.5e-11 44.6 1.6 2.6 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 KOH00750.1 - 0.00031 19.7 0.0 0.00078 18.4 0.0 1.6 1 0 0 1 1 1 1 Kinase-like C2 PF00168.25 KOH00750.1 - 0.00032 20.4 0.0 0.00095 18.9 0.0 1.8 1 0 0 1 1 1 1 C2 domain FliC PF12445.3 KOH00750.1 - 0.046 13.8 3.0 0.37 10.9 0.1 2.5 2 0 0 2 2 2 0 Flagellin protein zf-tcix PF14952.1 KOH00750.1 - 5.6 6.3 11.3 0.86 8.9 1.3 2.7 1 1 1 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding DUF4206 PF13901.1 KOH00750.1 - 9.6 5.7 32.6 0.58 9.6 4.7 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4206) SopA PF13981.1 KOH00751.1 - 0.022 14.7 0.0 0.09 12.7 0.0 2.0 2 0 0 2 2 2 0 SopA-like central domain zf-RING_2 PF13639.1 KOH00751.1 - 0.46 10.3 12.1 0.34 10.7 2.2 3.4 3 0 0 3 3 3 0 Ring finger domain HLH PF00010.21 KOH00752.1 - 1.6e-13 50.0 0.2 3.8e-13 48.9 0.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Sds3 PF08598.6 KOH00752.1 - 9 5.7 12.2 0.18 11.3 1.1 2.7 2 1 1 3 3 3 0 Sds3-like Got1 PF04178.7 KOH00753.1 - 1.5e-30 105.6 19.2 2.1e-30 105.2 13.3 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family ABC2_membrane_5 PF13346.1 KOH00753.1 - 0.41 9.9 15.0 20 4.3 9.9 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF1049 PF06305.6 KOH00753.1 - 0.44 10.0 2.3 19 4.8 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) Arrestin_C PF02752.17 KOH00754.1 - 7.5e-16 58.4 0.4 1.7e-14 54.0 0.0 3.2 3 2 1 4 4 4 1 Arrestin (or S-antigen), C-terminal domain ATP-synt_ab PF00006.20 KOH00755.1 - 8.6e-71 237.8 0.0 1.3e-70 237.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 KOH00755.1 - 8.7e-27 93.8 0.3 2.7e-26 92.2 0.2 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 KOH00755.1 - 1.1e-16 60.8 1.5 2.7e-16 59.5 1.0 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_25 PF13481.1 KOH00755.1 - 0.012 15.0 0.0 0.023 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain HAS-barrel PF09378.5 KOH00755.1 - 0.013 15.4 0.3 0.042 13.7 0.2 2.0 1 1 0 1 1 1 0 HAS barrel domain Tex_N PF09371.5 KOH00755.1 - 0.027 13.7 0.4 0.49 9.6 0.0 2.3 2 0 0 2 2 2 0 Tex-like protein N-terminal domain FAD_binding_3 PF01494.14 KOH00756.1 - 8.8e-23 80.9 0.0 1.6e-22 80.0 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 KOH00756.1 - 6.8e-07 29.2 0.0 1.7e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOH00756.1 - 1.7e-06 27.2 0.0 4.9e-06 25.7 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOH00756.1 - 2e-06 28.1 0.1 3.9e-05 23.9 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 KOH00756.1 - 2.9e-06 26.4 0.0 4.6e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A 3HCDH_N PF02737.13 KOH00756.1 - 0.00023 20.8 0.0 0.00044 19.9 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SE PF08491.5 KOH00756.1 - 0.00029 19.7 0.0 0.0033 16.2 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase ApbA PF02558.11 KOH00756.1 - 0.00038 19.9 0.0 0.00075 18.9 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.9 KOH00756.1 - 0.0036 17.2 0.1 0.0066 16.3 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 KOH00756.1 - 0.004 16.0 0.0 0.0065 15.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 KOH00756.1 - 0.0055 15.2 0.0 0.019 13.4 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein UDPG_MGDP_dh_N PF03721.9 KOH00756.1 - 0.0063 15.9 0.0 0.012 14.9 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.18 KOH00756.1 - 0.0079 15.9 0.0 0.02 14.6 0.0 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.10 KOH00756.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ThiF PF00899.16 KOH00756.1 - 0.066 13.0 0.1 0.18 11.6 0.1 1.8 1 0 0 1 1 1 0 ThiF family Trp_halogenase PF04820.9 KOH00756.1 - 0.097 11.2 0.0 5.6 5.4 0.0 2.3 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.1 KOH00756.1 - 0.11 12.6 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOH00756.1 - 0.11 11.5 1.0 0.17 10.9 0.7 1.4 1 1 0 1 1 1 0 FAD dependent oxidoreductase Cnd2 PF05786.9 KOH00757.1 - 1.5e-134 450.2 40.7 2e-134 449.7 28.2 1.1 1 0 0 1 1 1 1 Condensin complex subunit 2 4HBT PF03061.17 KOH00758.1 - 1.5e-05 25.0 0.0 3.4e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Thioesterase superfamily Rox3 PF08633.5 KOH00759.1 - 8.6e-71 238.2 1.3 9.8e-71 238.0 0.9 1.0 1 0 0 1 1 1 1 Rox3 mediator complex subunit Ribosomal_L32e PF01655.13 KOH00760.1 - 4.2e-45 152.2 2.8 5.2e-45 151.9 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Srg PF02118.16 KOH00760.1 - 0.071 12.5 1.0 0.099 12.0 0.7 1.1 1 0 0 1 1 1 0 Srg family chemoreceptor DUF3437 PF11919.3 KOH00760.1 - 0.078 12.7 0.2 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) MFS_2 PF13347.1 KOH00761.1 - 0.0084 14.5 0.1 0.01 14.2 0.0 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein Peptidase_M24 PF00557.19 KOH00762.1 - 1.6e-53 181.3 0.0 2.1e-53 180.9 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Protocadherin PF08374.6 KOH00762.1 - 0.74 9.4 3.6 1.2 8.6 2.0 1.7 2 0 0 2 2 2 0 Protocadherin Ribosomal_S21 PF01165.15 KOH00763.1 - 1e-12 47.3 2.0 2e-12 46.3 0.7 2.0 2 0 0 2 2 2 1 Ribosomal protein S21 Aa_trans PF01490.13 KOH00764.1 - 7.6e-122 406.7 19.6 8.6e-122 406.5 13.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 KOH00764.1 - 4.2e-07 29.1 10.1 4.2e-07 29.1 7.0 2.1 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family PI3_PI4_kinase PF00454.22 KOH00765.1 - 2e-55 187.8 2.1 5.1e-54 183.2 0.0 3.6 3 0 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.3 KOH00765.1 - 3.4e-32 111.3 3.5 3.4e-32 111.3 2.4 2.8 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair FATC PF02260.15 KOH00765.1 - 6.3e-14 51.1 1.4 2.3e-13 49.3 0.1 2.4 2 0 0 2 2 2 1 FATC domain Ribosomal_L14 PF00238.14 KOH00766.1 - 1.7e-30 105.2 0.0 1.8e-30 105.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e NT-C2 PF10358.4 KOH00767.1 - 3.8e-48 162.6 1.4 1.1e-47 161.1 1.2 1.7 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins PH PF00169.24 KOH00768.1 - 2.4e-14 53.3 0.0 2.4e-14 53.3 0.0 2.7 2 1 0 2 2 2 1 PH domain SAM_2 PF07647.12 KOH00768.1 - 3.6e-13 49.1 0.2 7.9e-13 48.0 0.0 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.23 KOH00768.1 - 2.1e-12 46.2 0.2 4.4e-12 45.1 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOH00768.1 - 3.7e-09 36.0 0.1 7.2e-09 35.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.1 KOH00768.1 - 2.3e-08 34.2 4.6 3.7e-08 33.6 0.0 3.4 2 1 1 3 3 3 1 Pleckstrin homology domain PH_8 PF15409.1 KOH00768.1 - 9.9e-06 25.5 0.0 0.00049 20.1 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain SH3_2 PF07653.12 KOH00768.1 - 0.00037 19.9 0.0 0.00076 18.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.25 KOH00768.1 - 0.063 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) TPR_2 PF07719.12 KOH00769.1 - 4.3e-39 129.3 9.3 9e-07 28.3 0.1 9.0 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_11 PF13414.1 KOH00769.1 - 5.6e-33 112.4 19.7 1.1e-12 47.3 1.0 7.6 4 2 6 10 10 10 6 TPR repeat TPR_1 PF00515.23 KOH00769.1 - 8.3e-33 110.6 12.0 5.6e-09 35.2 0.0 8.7 8 0 0 8 8 8 6 Tetratricopeptide repeat Apc3 PF12895.2 KOH00769.1 - 4.5e-29 100.4 23.5 2.4e-16 59.6 2.9 4.7 4 0 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 KOH00769.1 - 2e-26 89.7 7.5 9.8e-05 21.8 0.1 8.7 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.1 KOH00769.1 - 2.4e-25 88.2 4.2 4.2e-06 26.6 0.6 7.9 6 2 2 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOH00769.1 - 3.9e-21 75.1 0.2 1.3e-07 32.0 0.0 5.3 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOH00769.1 - 1.7e-20 71.4 8.5 6e-06 26.0 0.2 8.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOH00769.1 - 1.6e-13 49.9 0.1 0.027 15.0 0.0 6.3 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOH00769.1 - 1.7e-13 50.0 9.6 0.027 14.9 0.0 8.0 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOH00769.1 - 2.1e-13 50.3 2.8 0.00071 19.8 0.0 4.7 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_9 PF13371.1 KOH00769.1 - 1.8e-09 37.2 0.1 7.5e-05 22.5 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOH00769.1 - 2.4e-09 36.2 4.8 1.6 8.7 0.0 7.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_15 PF13429.1 KOH00769.1 - 8.5e-05 21.7 0.0 0.015 14.3 0.0 2.9 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_20 PF14561.1 KOH00769.1 - 0.0005 20.1 0.0 0.2 11.8 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOH00769.1 - 0.0038 17.1 1.6 0.67 9.9 0.0 4.8 6 0 0 6 6 6 1 Tetratricopeptide repeat Sel1 PF08238.7 KOH00769.1 - 0.11 13.1 5.6 11 6.8 0.1 4.6 5 0 0 5 5 4 0 Sel1 repeat ALG3 PF05208.8 KOH00770.1 - 3.8e-143 477.1 20.8 4.8e-143 476.8 14.4 1.1 1 0 0 1 1 1 1 ALG3 protein GatB_N PF02934.10 KOH00772.1 - 1.8e-92 309.3 0.0 2.4e-92 308.8 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.13 KOH00772.1 - 3.7e-30 104.5 0.0 6e-30 103.9 0.0 1.3 1 0 0 1 1 1 1 GatB domain Nucleoporin_C PF03177.9 KOH00773.1 - 3.9e-126 421.9 14.8 5.7e-126 421.4 10.3 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 KOH00773.1 - 4.2e-113 378.2 8.4 4.2e-113 378.2 5.8 2.3 2 0 0 2 2 2 1 Nup133 N terminal like Atg8 PF02991.11 KOH00774.1 - 8.6e-51 170.2 0.1 9.8e-51 170.0 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 KOH00774.1 - 7.2e-07 29.3 0.0 9.2e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 tRNA-synt_1 PF00133.17 KOH00775.1 - 1.3e-239 796.2 0.6 9.6e-239 793.3 0.1 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 KOH00775.1 - 1.8e-26 92.7 0.0 6.3e-26 90.9 0.0 2.0 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 KOH00775.1 - 2.1e-19 69.4 1.8 1.2e-06 27.4 0.4 4.2 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 KOH00775.1 - 0.0021 17.2 0.0 0.0061 15.7 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain AAR2 PF05282.6 KOH00776.1 - 2e-58 198.0 7.3 2.3e-58 197.8 5.1 1.0 1 0 0 1 1 1 1 AAR2 protein Ribosomal_S8e PF01201.17 KOH00777.1 - 7.5e-51 171.7 2.6 8.6e-51 171.5 1.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e zf-CSL PF05207.8 KOH00778.1 - 3e-24 84.2 1.3 3.8e-24 83.9 0.9 1.1 1 0 0 1 1 1 1 CSL zinc finger TF_Zn_Ribbon PF08271.7 KOH00778.1 - 0.02 14.2 1.0 0.04 13.2 0.7 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding zf-RING_4 PF14570.1 KOH00778.1 - 0.31 10.6 2.1 0.55 9.8 1.4 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain ADH_zinc_N_2 PF13602.1 KOH00779.1 - 1e-12 49.0 0.0 1.8e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOH00779.1 - 1.1e-06 28.4 0.1 2e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOH00779.1 - 0.0054 16.2 0.0 0.018 14.6 0.0 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Pribosyltran_N PF13793.1 KOH00780.1 - 2.1e-42 143.5 0.1 4.5e-40 136.0 0.0 2.3 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 KOH00780.1 - 1.9e-33 115.7 0.5 1.3e-27 96.6 0.1 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 KOH00780.1 - 7.3e-14 51.5 0.8 8.5e-13 48.1 0.4 2.2 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.1 KOH00780.1 - 0.00027 20.1 0.0 0.00049 19.3 0.0 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase UCH PF00443.24 KOH00781.1 - 2.2e-75 253.2 9.7 7.2e-75 251.5 6.7 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOH00781.1 - 3e-27 95.8 11.6 2e-23 83.2 1.7 2.8 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Fungal_trans PF04082.13 KOH00782.1 - 2.2e-28 98.8 2.9 4.2e-28 97.9 2.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOH00782.1 - 4.2e-11 42.5 10.4 6.7e-11 41.9 7.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AhpC-TSA PF00578.16 KOH00783.1 - 1e-32 112.4 0.1 1.5e-32 111.8 0.1 1.3 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.4 KOH00783.1 - 6.2e-15 54.5 0.1 1e-14 53.8 0.1 1.3 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.5 KOH00783.1 - 6.7e-11 41.9 0.1 1e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.1 KOH00783.1 - 0.13 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme Kinesin PF00225.18 KOH00784.1 - 1.7e-109 365.5 9.3 1.7e-109 365.5 6.4 2.3 2 1 0 2 2 2 1 Kinesin motor domain Apolipoprotein PF01442.13 KOH00784.1 - 3e-06 26.8 6.0 0.012 15.1 0.4 3.6 2 1 2 4 4 4 3 Apolipoprotein A1/A4/E domain DinI PF06183.8 KOH00784.1 - 0.054 13.5 1.5 1.3 9.0 0.3 3.3 2 0 0 2 2 2 0 DinI-like family Sel1 PF08238.7 KOH00785.1 - 1.3e-41 140.0 16.2 5.7e-10 39.4 0.8 7.6 7 0 0 7 7 7 7 Sel1 repeat Sec7 PF01369.15 KOH00786.1 - 5.9e-30 104.3 1.1 1.1e-29 103.4 0.8 1.4 1 0 0 1 1 1 1 Sec7 domain SEP PF08059.8 KOH00788.1 - 4.9e-26 90.8 0.6 1.4e-25 89.3 0.1 2.1 2 0 0 2 2 2 1 SEP domain UBX PF00789.15 KOH00788.1 - 1.6e-19 69.7 0.0 3.1e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.1 KOH00788.1 - 1.3e-07 31.0 2.2 2.2e-07 30.2 1.5 1.4 1 0 0 1 1 1 1 UBA-like domain GET2 PF08690.5 KOH00788.1 - 0.72 9.0 5.0 1.6 7.8 3.5 1.5 1 0 0 1 1 1 0 GET complex subunit GET2 PTH2 PF01981.11 KOH00789.1 - 1.6e-44 150.2 0.1 2.2e-44 149.8 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 CENP-B_dimeris PF09026.5 KOH00789.1 - 0.034 14.3 2.0 0.053 13.7 1.4 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Myc_N PF01056.13 KOH00789.1 - 0.04 13.0 0.2 0.045 12.9 0.1 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Nucleoplasmin PF03066.10 KOH00789.1 - 0.062 12.8 7.0 0.16 11.4 4.8 1.6 2 0 0 2 2 2 0 Nucleoplasmin FAM176 PF14851.1 KOH00789.1 - 0.085 12.5 0.6 0.12 12.0 0.1 1.5 2 0 0 2 2 2 0 FAM176 family DNA_pol_phi PF04931.8 KOH00789.1 - 1.8 6.2 9.3 2.4 5.8 6.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi PP2C PF00481.16 KOH00790.1 - 6.7e-85 284.5 0.1 1.1e-84 283.8 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Myb_DNA-bind_6 PF13921.1 KOH00791.1 - 6.1e-12 45.4 3.6 5.9e-10 39.0 0.2 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 KOH00791.1 - 2.2e-07 30.8 1.2 1.3e-06 28.3 0.2 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain Ribosomal_60s PF00428.14 KOH00791.1 - 0.0002 21.6 4.6 0.00041 20.6 3.2 1.4 1 0 0 1 1 1 1 60s Acidic ribosomal protein Rap1_C PF11626.3 KOH00791.1 - 0.016 15.0 0.4 0.84 9.5 0.1 2.4 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MOZ_SAS PF01853.13 KOH00792.1 - 4.1e-79 264.2 1.2 6.8e-79 263.4 0.8 1.4 1 0 0 1 1 1 1 MOZ/SAS family RR_TM4-6 PF06459.7 KOH00792.1 - 9.1 6.0 14.5 19 5.0 10.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RRM_6 PF14259.1 KOH00793.1 - 3.9e-09 36.3 0.0 8.7e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOH00793.1 - 6.4e-07 28.9 0.0 2.3e-06 27.1 0.0 2.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOH00793.1 - 0.00021 21.0 0.0 0.00057 19.6 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_2 PF04059.7 KOH00793.1 - 0.016 15.1 0.1 0.042 13.8 0.1 1.6 1 0 0 1 1 1 0 RNA recognition motif 2 SNAP PF14938.1 KOH00794.1 - 2.5e-103 345.1 8.5 2.8e-103 344.9 5.9 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KOH00794.1 - 9.1e-08 31.9 3.4 0.0039 17.1 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOH00794.1 - 0.0001 22.4 0.8 34 5.1 0.0 5.2 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOH00794.1 - 0.0076 15.8 7.7 0.025 14.2 0.1 3.7 1 1 3 4 4 4 2 TPR repeat TPR_8 PF13181.1 KOH00794.1 - 0.012 15.3 7.6 2.2 8.2 0.0 4.8 3 2 2 5 5 5 0 Tetratricopeptide repeat Foie-gras_1 PF11817.3 KOH00794.1 - 0.023 14.1 0.1 0.049 13.1 0.0 1.5 1 1 0 1 1 1 0 Foie gras liver health family 1 DUF2225 PF09986.4 KOH00794.1 - 0.034 13.6 1.8 1.2 8.5 1.2 2.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_7 PF13176.1 KOH00794.1 - 0.16 11.8 1.5 3 7.8 0.0 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 KOH00794.1 - 0.21 11.5 7.4 2.4 8.0 0.8 3.9 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.12 KOH00794.1 - 0.22 11.5 6.5 10 6.3 0.1 5.1 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOH00794.1 - 0.53 9.9 7.3 1 9.0 0.1 4.3 4 2 2 6 6 6 0 Tetratricopeptide repeat Yippee-Mis18 PF03226.9 KOH00795.1 - 7.2e-19 67.6 3.9 9.4e-19 67.2 2.7 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Evr1_Alr PF04777.8 KOH00795.1 - 0.044 13.6 1.4 0.08 12.8 0.1 1.8 1 1 1 2 2 2 0 Erv1 / Alr family EF-hand_4 PF12763.2 KOH00796.1 - 2.2e-33 114.0 2.2 6.7e-10 38.6 0.0 4.3 4 0 0 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.1 KOH00796.1 - 3.4e-11 43.1 0.1 0.0049 16.9 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.27 KOH00796.1 - 2.5e-09 35.7 0.5 0.00092 18.3 0.0 3.6 3 0 0 3 3 3 2 EF hand UBA PF00627.26 KOH00796.1 - 5.1e-08 32.5 0.1 1.3e-07 31.2 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain DUF3584 PF12128.3 KOH00796.1 - 6.9e-06 23.7 52.4 6.9e-06 23.7 36.3 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3584) EF-hand_6 PF13405.1 KOH00796.1 - 1.1e-05 24.9 0.2 0.2 11.6 0.0 4.1 4 0 0 4 4 4 2 EF-hand domain UBA_4 PF14555.1 KOH00796.1 - 8.6e-05 21.9 0.5 0.00024 20.5 0.3 1.8 1 0 0 1 1 1 1 UBA-like domain CENP-F_leu_zip PF10473.4 KOH00796.1 - 0.0001 22.1 30.9 0.0001 22.1 21.4 3.1 3 1 1 4 4 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.7 KOH00796.1 - 0.0031 17.2 25.2 0.0031 17.2 17.5 4.2 1 1 2 4 4 4 1 TPR/MLP1/MLP2-like protein EF-hand_8 PF13833.1 KOH00796.1 - 0.0038 16.8 0.2 4.6 6.9 0.0 3.8 3 0 0 3 3 3 1 EF-hand domain pair IncA PF04156.9 KOH00796.1 - 0.097 12.2 55.7 0.16 11.5 9.6 3.8 1 1 2 3 3 3 0 IncA protein Filament PF00038.16 KOH00796.1 - 3.1 7.1 56.4 0.13 11.7 28.4 2.4 1 1 1 2 2 2 0 Intermediate filament protein PPP4R2 PF09184.6 KOH00797.1 - 4.1e-68 230.0 24.5 4.1e-68 230.0 17.0 2.1 1 1 0 2 2 2 1 PPP4R2 Peptidase_M16 PF00675.15 KOH00798.1 - 6.2e-31 107.1 1.4 9.2e-31 106.6 0.2 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 KOH00798.1 - 1e-26 93.7 0.1 1.8e-26 92.9 0.1 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Pup_ligase PF03136.10 KOH00798.1 - 0.074 11.6 0.0 0.17 10.4 0.0 1.5 2 0 0 2 2 2 0 Pup-ligase protein Transp_cyt_pur PF02133.10 KOH00800.1 - 9.9e-151 502.2 36.0 1.1e-150 502.0 24.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Transp_cyt_pur PF02133.10 KOH00801.1 - 3.3e-169 563.0 37.9 3.9e-169 562.8 26.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Proteasome PF00227.21 KOH00802.1 - 3.6e-35 120.9 0.1 2.5e-34 118.2 0.1 1.9 1 1 0 1 1 1 1 Proteasome subunit ER_lumen_recept PF00810.13 KOH00803.1 - 1.1e-42 145.9 12.7 1.6e-42 145.4 8.8 1.2 1 0 0 1 1 1 1 ER lumen protein retaining receptor CTP_synth_N PF06418.9 KOH00805.1 - 1.5e-119 398.1 0.4 2.1e-119 397.6 0.2 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 KOH00805.1 - 7.8e-56 188.5 0.0 1.2e-55 188.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 KOH00805.1 - 5.4e-05 22.7 0.0 0.00027 20.4 0.0 2.1 1 1 0 1 1 1 1 Peptidase C26 CbiA PF01656.18 KOH00805.1 - 0.0079 15.6 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Ribosomal_L16 PF00252.13 KOH00806.1 - 6.7e-34 116.5 0.2 9.6e-34 115.9 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Adaptin_N PF01602.15 KOH00807.1 - 7.2e-136 453.5 19.9 8.8e-136 453.2 13.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 KOH00807.1 - 1.4e-08 35.0 0.2 5.2e-08 33.2 0.1 2.0 1 0 0 1 1 1 1 Adaptin C-terminal domain Alpha_adaptin_C PF02296.11 KOH00807.1 - 1.5e-05 24.8 0.0 4.5e-05 23.3 0.0 1.9 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Ala_racemase_N PF01168.15 KOH00808.1 - 1.8e-41 142.0 0.0 2.2e-41 141.8 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DUF3420 PF11900.3 KOH00808.1 - 0.43 10.7 2.4 0.71 10.0 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3420) Pol_alpha_B_N PF08418.5 KOH00809.1 - 1.1e-75 254.4 7.4 1.8e-75 253.7 5.1 1.3 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.11 KOH00809.1 - 4.2e-59 199.3 0.1 4.2e-59 199.3 0.1 1.7 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B CLASP_N PF12348.3 KOH00810.1 - 4.3e-73 245.4 7.4 6e-68 228.6 3.1 2.8 2 0 0 2 2 2 2 CLASP N terminal GTP_cyclohydro2 PF00925.15 KOH00811.1 - 3.8e-57 192.2 0.1 2.5e-52 176.5 0.0 2.1 2 0 0 2 2 2 2 GTP cyclohydrolase II KH_1 PF00013.24 KOH00812.1 - 3.4e-28 97.0 12.2 3.6e-10 39.3 0.6 3.2 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 KOH00812.1 - 6.1e-20 70.4 12.4 3.3e-10 39.3 0.5 3.6 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 KOH00812.1 - 4.5e-05 22.9 9.0 0.066 12.7 0.1 3.6 3 1 0 3 3 3 3 KH domain KH_4 PF13083.1 KOH00812.1 - 0.00017 21.1 0.1 0.85 9.3 0.0 3.7 3 0 0 3 3 3 2 KH domain KH_5 PF13184.1 KOH00812.1 - 0.043 13.6 6.1 0.16 11.7 0.1 3.1 3 0 0 3 3 3 0 NusA-like KH domain DUF4054 PF13262.1 KOH00813.1 - 0.24 11.6 1.9 0.5 10.6 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4054) Mito_carr PF00153.22 KOH00814.1 - 6.2e-70 230.9 5.7 9.1e-24 82.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PsbX PF06596.6 KOH00814.1 - 0.63 9.7 4.8 1.2 8.8 0.8 2.7 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) zf-LITAF-like PF10601.4 KOH00815.1 - 0.037 13.8 0.5 0.095 12.5 0.3 1.7 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain Cys_rich_KTR PF14205.1 KOH00815.1 - 0.23 10.9 3.2 4.4 6.8 0.2 2.8 3 0 0 3 3 3 0 Cysteine-rich KTR zf-Mss51 PF13824.1 KOH00815.1 - 0.31 10.9 4.3 9.9 6.1 0.3 2.7 2 1 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Zn_Tnp_IS1595 PF12760.2 KOH00815.1 - 0.43 10.4 5.7 3.5 7.5 0.5 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.7 KOH00815.1 - 1.4 8.3 4.7 16 4.9 0.9 2.7 2 1 1 3 3 3 0 TFIIB zinc-binding Cys_rich_CPCC PF14206.1 KOH00815.1 - 1.4 8.5 4.5 0.57 9.7 0.2 2.2 2 0 0 2 2 2 0 Cysteine-rich CPCC RecR PF02132.10 KOH00815.1 - 8.5 5.9 6.5 5.3 6.5 1.1 2.2 2 0 0 2 2 2 0 RecR protein DUF2423 PF10338.4 KOH00817.1 - 1.8e-19 69.3 6.5 1.8e-19 69.3 4.5 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) MSC PF09402.5 KOH00817.1 - 0.14 10.8 2.7 0.15 10.7 1.9 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Med12-LCEWAV PF12145.3 KOH00817.1 - 0.21 10.0 3.5 0.23 9.8 2.4 1.0 1 0 0 1 1 1 0 Eukaryotic Mediator 12 subunit domain Ribosomal_L19e PF01280.15 KOH00818.1 - 4.4e-58 195.2 11.4 4.4e-58 195.2 7.9 1.5 2 0 0 2 2 2 1 Ribosomal protein L19e LSM PF01423.17 KOH00820.1 - 6.5e-17 60.8 0.3 1.1e-16 60.1 0.2 1.4 1 0 0 1 1 1 1 LSM domain UAF_Rrn10 PF05234.6 KOH00821.1 - 8.5e-62 206.5 0.3 1e-61 206.2 0.2 1.0 1 0 0 1 1 1 1 UAF complex subunit Rrn10 Nol1_Nop2_Fmu PF01189.12 KOH00822.1 - 1.5e-125 418.2 0.1 1.8e-108 362.2 0.0 2.1 1 1 1 2 2 2 2 NOL1/NOP2/sun family FtsJ PF01728.14 KOH00822.1 - 0.00055 19.9 0.0 0.0011 18.9 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase RrnaAD PF00398.15 KOH00822.1 - 0.03 13.3 0.0 0.059 12.3 0.0 1.5 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase MCM PF00493.18 KOH00823.1 - 5.4e-141 469.1 0.8 8.8e-141 468.4 0.6 1.3 1 0 0 1 1 1 1 MCM2/3/5 family MCM2_N PF12619.3 KOH00823.1 - 1.5e-28 99.7 32.9 1.5e-28 99.7 22.8 3.6 5 0 0 5 5 5 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.1 KOH00823.1 - 9e-14 51.9 0.1 2.3e-13 50.6 0.0 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 KOH00823.1 - 2.7e-09 36.5 0.0 2.6e-07 30.0 0.0 2.5 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KOH00823.1 - 1.7e-07 31.0 0.0 4e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 KOH00823.1 - 0.00031 20.3 0.0 0.0021 17.6 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 KOH00823.1 - 0.0013 18.2 0.1 0.0079 15.6 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain Cut8_N PF14482.1 KOH00823.1 - 0.011 15.6 1.6 0.011 15.6 1.1 2.7 3 0 0 3 3 3 0 Cut8 proteasome-binding domain AAA PF00004.24 KOH00823.1 - 0.027 14.6 1.7 0.044 13.9 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Lon_C PF05362.8 KOH00824.1 - 4.5e-65 218.7 0.0 1.2e-64 217.4 0.0 1.7 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON PF02190.11 KOH00824.1 - 9.4e-35 120.1 12.0 5e-34 117.7 8.3 2.3 1 1 0 1 1 1 1 ATP-dependent protease La (LON) domain AAA PF00004.24 KOH00824.1 - 2.5e-22 79.4 0.0 7.1e-22 78.0 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOH00824.1 - 3.6e-07 30.0 0.0 1e-06 28.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.1 KOH00824.1 - 3.1e-06 26.7 0.0 9e-06 25.2 0.0 1.8 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_22 PF13401.1 KOH00824.1 - 6.3e-05 23.1 0.0 0.0018 18.4 0.0 3.0 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOH00824.1 - 0.00022 22.0 0.0 0.00022 22.0 0.0 3.6 5 0 0 5 5 4 1 AAA domain AAA_16 PF13191.1 KOH00824.1 - 0.0003 20.8 0.2 0.0071 16.3 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.17 KOH00824.1 - 0.0015 18.7 0.0 0.069 13.3 0.0 2.8 2 0 0 2 2 2 1 RNA helicase AAA_14 PF13173.1 KOH00824.1 - 0.0022 17.8 0.1 0.012 15.4 0.0 2.4 3 0 0 3 3 2 1 AAA domain SKI PF01202.17 KOH00824.1 - 0.0067 16.3 0.5 0.027 14.3 0.0 2.4 2 0 0 2 2 1 1 Shikimate kinase AAA_18 PF13238.1 KOH00824.1 - 0.0067 16.7 0.0 0.0067 16.7 0.0 3.6 4 0 0 4 4 3 1 AAA domain RuvB_N PF05496.7 KOH00824.1 - 0.01 14.9 0.0 0.069 12.1 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus NTPase_1 PF03266.10 KOH00824.1 - 0.016 14.9 0.5 0.49 10.0 0.0 3.0 2 1 1 3 3 3 0 NTPase DUF258 PF03193.11 KOH00824.1 - 0.048 12.8 0.2 0.15 11.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 KOH00824.1 - 0.062 13.2 1.4 4.8 7.1 0.0 3.3 3 0 0 3 3 3 0 50S ribosome-binding GTPase CBFD_NFYB_HMF PF00808.18 KOH00825.1 - 8e-25 86.6 0.0 1.2e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 KOH00825.1 - 3.6e-06 27.0 0.0 5.8e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Rft-1 PF04506.8 KOH00826.1 - 6.6e-230 764.1 37.5 7.4e-230 763.9 26.0 1.0 1 0 0 1 1 1 1 Rft protein BNR PF02012.15 KOH00827.1 - 7.4e-09 34.1 27.3 0.079 12.8 0.2 7.5 7 0 0 7 7 7 5 BNR/Asp-box repeat DUF4118 PF13493.1 KOH00827.1 - 0.087 13.0 1.5 0.16 12.2 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4118) BNR PF02012.15 KOH00828.1 - 0.018 14.7 11.3 3.3 7.9 0.3 4.2 4 0 0 4 4 4 0 BNR/Asp-box repeat PSII_BNR PF14870.1 KOH00828.1 - 0.051 12.5 1.2 0.15 11.0 0.0 2.2 2 1 0 2 2 2 0 Photosynthesis system II assembly factor YCF48 BNR_2 PF13088.1 KOH00828.1 - 0.057 12.7 0.3 0.45 9.7 0.2 2.3 1 1 1 2 2 2 0 BNR repeat-like domain TSGP1 PF07771.6 KOH00828.1 - 0.14 12.0 4.3 0.72 9.7 0.1 2.4 1 1 1 2 2 2 0 Tick salivary peptide group 1 Pkinase PF00069.20 KOH00829.1 - 2.5e-71 239.8 0.0 3.1e-71 239.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00829.1 - 4e-31 108.0 0.0 5.9e-31 107.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH00829.1 - 0.0057 15.6 0.0 0.025 13.5 0.0 1.9 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOH00829.1 - 0.061 12.3 0.1 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOH00829.1 - 0.066 12.9 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family AcetylCoA_hydro PF02550.10 KOH00830.1 - 3.6e-79 265.1 0.0 1.1e-78 263.5 0.0 1.8 2 0 0 2 2 2 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.1 KOH00830.1 - 1e-38 132.4 0.0 1.6e-38 131.8 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain CitF PF04223.7 KOH00830.1 - 0.0035 16.0 0.0 0.0055 15.4 0.0 1.3 1 0 0 1 1 1 1 Citrate lyase, alpha subunit (CitF) CoA_trans PF01144.18 KOH00830.1 - 0.026 13.7 0.0 0.11 11.7 0.0 2.0 2 0 0 2 2 2 0 Coenzyme A transferase Rrn6 PF10214.4 KOH00831.1 - 8.5e-157 523.4 33.5 9.9e-157 523.2 23.2 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Formyl_trans_N PF00551.14 KOH00832.1 - 8.2e-42 142.7 0.0 9.9e-42 142.5 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase Acyltransferase PF01553.16 KOH00833.1 - 1.8e-11 43.5 0.0 1e-10 41.1 0.0 2.2 1 1 0 1 1 1 1 Acyltransferase HeLo PF14479.1 KOH00834.1 - 0.024 14.3 1.2 0.032 13.9 0.8 1.4 1 0 0 1 1 1 0 Prion-inhibition and propagation DUF3635 PF12330.3 KOH00835.1 - 1.5e-27 95.5 0.4 5.4e-27 93.7 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3635) WD40 PF00400.27 KOH00836.1 - 6.5e-43 143.1 14.1 1.7e-10 40.3 0.1 7.9 7 1 0 7 7 7 6 WD domain, G-beta repeat HIRA_B PF09453.5 KOH00836.1 - 1.6e-08 33.8 1.1 4.3e-08 32.5 0.7 1.8 1 0 0 1 1 1 1 HIRA B motif Hira PF07569.6 KOH00836.1 - 1.4e-06 27.6 0.0 3.4e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 TUP1-like enhancer of split PD40 PF07676.7 KOH00836.1 - 2.3e-05 23.9 0.3 1.4 8.6 0.0 4.3 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOH00836.1 - 0.0011 18.6 0.1 1.8 8.2 0.0 4.2 5 0 0 5 5 5 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 KOH00836.1 - 0.0061 15.6 0.0 0.11 11.5 0.0 2.7 2 0 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal IKI3 PF04762.7 KOH00836.1 - 0.0066 14.3 0.0 1.1 6.9 0.0 2.5 2 0 0 2 2 2 2 IKI3 family PQQ_2 PF13360.1 KOH00836.1 - 0.021 14.2 0.1 6 6.2 0.0 3.4 3 1 0 3 3 3 0 PQQ-like domain CbiA PF01656.18 KOH00836.1 - 0.044 13.1 0.0 0.096 12.0 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain SH3_1 PF00018.23 KOH00837.1 - 2.4e-41 138.8 3.9 5.3e-14 51.3 0.0 4.2 4 0 0 4 4 4 3 SH3 domain SHD1 PF03983.7 KOH00837.1 - 9.3e-34 114.9 0.0 2.1e-33 113.7 0.0 1.6 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_9 PF14604.1 KOH00837.1 - 1.6e-33 114.0 6.4 2.4e-11 43.0 0.1 4.0 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.12 KOH00837.1 - 9.2e-29 98.7 0.0 5.4e-08 32.1 0.0 4.4 4 0 0 4 4 4 3 Variant SH3 domain SH3_3 PF08239.6 KOH00837.1 - 0.0025 17.9 0.8 1.6 8.9 0.0 3.2 3 0 0 3 3 3 2 Bacterial SH3 domain DUF3104 PF11302.3 KOH00837.1 - 0.0072 15.6 0.1 0.029 13.7 0.0 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3104) Rsc14 PF08586.5 KOH00838.1 - 8.7e-40 135.2 0.2 1.3e-39 134.7 0.1 1.2 1 0 0 1 1 1 1 RSC complex, Rsc14/Ldb7 subunit zf-met2 PF12907.2 KOH00838.1 - 0.095 12.6 0.2 0.18 11.7 0.2 1.4 1 0 0 1 1 1 0 Zinc-binding zf-AN1 PF01428.11 KOH00838.1 - 0.76 9.6 3.7 0.18 11.7 0.3 1.6 2 0 0 2 2 2 0 AN1-like Zinc finger Fungal_trans PF04082.13 KOH00839.1 - 8.2e-38 129.7 5.4 8.2e-38 129.7 3.7 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOH00839.1 - 2.8e-09 36.7 14.2 2.8e-09 36.7 9.8 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DRIM PF07539.7 KOH00840.1 - 2.1e-49 166.5 1.1 1.4e-48 163.8 0.2 2.9 2 0 0 2 2 2 1 Down-regulated in metastasis HEAT PF02985.17 KOH00840.1 - 0.051 13.6 8.1 41 4.6 0.0 7.8 9 0 0 9 9 9 0 HEAT repeat Histone PF00125.19 KOH00841.1 - 6.5e-26 90.2 0.0 8.8e-26 89.8 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KOH00841.1 - 9.8e-06 25.5 0.0 1.5e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 KOH00842.1 - 1.4e-21 76.3 0.3 2e-21 75.8 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KOH00842.1 - 6.6e-06 26.1 0.1 1.4e-05 25.0 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 KOH00842.1 - 0.0013 18.9 0.0 0.0022 18.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Mitofilin PF09731.4 KOH00842.1 - 0.037 12.6 2.7 0.045 12.4 1.9 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF1018 PF06252.7 KOH00842.1 - 0.093 13.2 0.5 0.12 12.8 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) DUF77 PF01910.12 KOH00843.1 - 2.3e-29 100.9 0.1 2.6e-29 100.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function DUF77 Trehalase PF01204.13 KOH00844.1 - 6.2e-187 622.2 0.0 7.9e-187 621.9 0.0 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.6 KOH00844.1 - 7.6e-17 60.3 0.5 1.3e-16 59.5 0.3 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Prenyltransf PF01255.14 KOH00845.1 - 7.1e-79 264.0 0.0 8.7e-79 263.7 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase polyprenyl_synt PF00348.12 KOH00846.1 - 3.5e-53 180.1 0.0 4.7e-48 163.2 0.0 3.1 2 1 0 2 2 2 2 Polyprenyl synthetase DUF2990 PF11693.3 KOH00846.1 - 0.13 12.0 0.0 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2990) Mannosyl_trans2 PF04188.8 KOH00847.1 - 4.7e-136 454.2 38.1 3.6e-135 451.3 26.4 1.9 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V)) RCR PF12273.3 KOH00848.1 - 1.1e-39 135.9 0.6 1.8e-39 135.2 0.4 1.4 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red TMEM51 PF15345.1 KOH00848.1 - 0.02 14.5 0.0 0.03 14.0 0.0 1.3 1 1 0 1 1 1 0 Transmembrane protein 51 Peptidase_A8 PF01252.13 KOH00848.1 - 0.079 12.5 0.1 0.11 12.0 0.1 1.1 1 0 0 1 1 1 0 Signal peptidase (SPase) II DUF3290 PF11694.3 KOH00848.1 - 0.14 11.9 0.3 0.23 11.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) ATG27 PF09451.5 KOH00848.1 - 0.16 11.2 0.4 0.24 10.5 0.3 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 CorA PF01544.13 KOH00848.1 - 0.36 9.8 2.3 0.5 9.3 1.6 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF1443 PF07280.6 KOH00848.1 - 0.94 9.0 5.1 2.4 7.7 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1443) Aldedh PF00171.17 KOH00849.1 - 1e-154 515.3 0.0 1.2e-154 515.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Sel1 PF08238.7 KOH00850.1 - 3.8e-06 27.3 2.5 0.00054 20.5 0.1 3.2 3 0 0 3 3 3 2 Sel1 repeat Histone PF00125.19 KOH00851.1 - 7.9e-15 54.7 0.2 9.6e-15 54.4 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KOH00851.1 - 7e-05 22.9 0.1 9.7e-05 22.4 0.0 1.4 1 1 0 1 1 1 1 Kinetochore component CENP-S TAF PF02969.12 KOH00851.1 - 8.3e-05 22.4 0.1 0.00012 21.9 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.18 KOH00851.1 - 0.00018 21.4 0.1 0.00032 20.6 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T PF15511.1 KOH00851.1 - 0.0021 17.3 0.0 0.0022 17.2 0.0 1.0 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T Bromo_TP PF07524.8 KOH00851.1 - 0.024 14.3 0.0 0.029 14.0 0.0 1.3 1 1 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.8 KOH00851.1 - 0.06 13.6 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.19 KOH00852.1 - 5.2e-30 103.3 0.7 8.5e-30 102.7 0.5 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KOH00852.1 - 9.4e-07 28.9 0.0 1.4e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 KOH00852.1 - 0.002 18.1 1.0 0.0025 17.8 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 KOH00852.1 - 0.058 13.1 0.1 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Pyrophosphatase PF00719.14 KOH00853.1 - 2.2e-53 179.8 0.2 3e-53 179.4 0.1 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase Glutaredoxin PF00462.19 KOH00854.1 - 5e-15 55.2 0.0 1.2e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_9 PF14595.1 KOH00854.1 - 0.0013 18.2 0.0 0.002 17.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 KOH00854.1 - 0.015 15.2 0.0 0.039 13.9 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_2 PF13098.1 KOH00854.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain DUF843 PF05814.6 KOH00854.1 - 0.2 11.4 0.1 0.2 11.4 0.1 1.9 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) Mannosyl_trans3 PF11051.3 KOH00855.1 - 2.1e-85 286.3 0.0 3.3e-85 285.7 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative CYSTM PF12734.2 KOH00856.1 - 7.1e-14 51.5 8.6 7.1e-14 51.5 6.0 5.1 1 1 2 3 3 3 1 Cysteine-rich TM module stress tolerance HEAT PF02985.17 KOH00857.1 - 1.1e-24 84.2 6.8 0.00046 20.0 0.0 9.9 9 0 0 9 9 9 4 HEAT repeat HEAT_EZ PF13513.1 KOH00857.1 - 6.8e-23 80.5 0.1 3e-11 43.4 0.0 8.6 8 0 0 8 8 8 2 HEAT-like repeat HEAT_2 PF13646.1 KOH00857.1 - 1.8e-18 66.6 0.0 3.4e-06 27.2 0.0 6.0 4 2 1 5 5 5 5 HEAT repeats Vac14_Fab1_bd PF12755.2 KOH00857.1 - 4.5e-05 23.7 0.2 1.7 9.1 0.0 5.0 5 1 1 6 6 6 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.3 KOH00857.1 - 0.013 14.8 0.0 0.59 9.4 0.0 3.2 3 0 0 3 3 3 0 CLASP N terminal IBN_N PF03810.14 KOH00857.1 - 0.013 15.3 0.2 0.12 12.3 0.1 2.7 1 1 0 1 1 1 0 Importin-beta N-terminal domain Arm PF00514.18 KOH00857.1 - 0.034 13.9 2.0 5.6 6.9 0.0 4.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat GalP_UDP_transf PF01087.17 KOH00858.1 - 4.4e-68 228.9 0.5 7.4e-68 228.2 0.4 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.12 KOH00858.1 - 1.6e-65 219.7 1.6 2e-65 219.4 0.3 1.7 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.18 KOH00858.1 - 0.00083 19.8 0.1 0.011 16.2 0.0 2.3 2 0 0 2 2 2 1 HIT domain Aldose_epim PF01263.15 KOH00859.1 - 4.3e-83 278.8 0.2 5.9e-83 278.4 0.2 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase Epimerase PF01370.16 KOH00859.1 - 2.3e-54 184.3 0.0 5.4e-54 183.1 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 KOH00859.1 - 2.2e-23 81.9 0.1 4.5e-23 80.9 0.1 1.6 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit Polysacc_synt_2 PF02719.10 KOH00859.1 - 3.4e-18 65.5 0.0 2.2e-16 59.6 0.0 2.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 KOH00859.1 - 6.4e-17 61.1 0.0 3.1e-16 58.8 0.0 1.8 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 KOH00859.1 - 1.8e-12 47.4 0.0 2.9e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.12 KOH00859.1 - 6.6e-12 44.9 0.0 1e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 KOH00859.1 - 3.6e-09 35.9 0.0 1.7e-08 33.6 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein KR PF08659.5 KOH00859.1 - 9.7e-09 35.1 0.0 1.8e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 KOH00859.1 - 7.1e-07 29.4 0.0 1.2e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding GalKase_gal_bdg PF10509.4 KOH00860.1 - 2.4e-22 77.9 0.0 5.6e-22 76.7 0.0 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.21 KOH00860.1 - 4.3e-15 55.5 0.2 1e-14 54.3 0.1 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 KOH00860.1 - 7.7e-10 38.8 0.0 1.8e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal Peptidase_M16_C PF05193.16 KOH00860.1 - 0.032 13.8 0.0 0.11 12.1 0.0 1.9 2 0 0 2 2 2 0 Peptidase M16 inactive domain Transp_cyt_pur PF02133.10 KOH00861.1 - 5.9e-182 605.1 36.3 6.9e-182 604.9 25.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Macro PF01661.16 KOH00862.1 - 4.2e-29 100.8 0.0 5.1e-29 100.5 0.0 1.1 1 0 0 1 1 1 1 Macro domain Chitin_synth_2 PF03142.10 KOH00863.1 - 3.4e-291 966.2 0.9 3.6e-291 966.1 0.0 1.4 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.1 KOH00863.1 - 8e-16 58.3 0.6 2.3e-15 56.8 0.4 1.9 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 KOH00863.1 - 2.3e-13 50.5 0.0 9.2e-11 41.9 0.0 2.5 2 1 0 2 2 2 2 Glycosyltransferase like family 2 Cyt-b5 PF00173.23 KOH00863.1 - 9e-06 25.4 0.1 0.0048 16.6 0.0 2.7 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_21 PF13506.1 KOH00863.1 - 0.0016 17.7 0.1 0.0051 16.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 KOH00863.1 - 0.003 17.2 0.0 0.056 13.1 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 SCO1-SenC PF02630.9 KOH00864.1 - 1.8e-73 245.8 0.0 2.5e-73 245.3 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 KOH00864.1 - 8.8e-07 28.6 0.0 1.9e-06 27.5 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.1 KOH00864.1 - 5.5e-05 23.1 0.0 0.00014 21.9 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like FAM60A PF15396.1 KOH00864.1 - 0.079 12.6 0.1 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein Family FAM60A DUF3918 PF13056.1 KOH00864.1 - 0.12 11.7 0.0 0.27 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) YchF-GTPase_C PF06071.8 KOH00865.1 - 5e-36 122.3 0.0 1.1e-35 121.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 KOH00865.1 - 7.3e-13 48.4 0.0 1.9e-12 47.1 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 KOH00865.1 - 0.00072 19.3 0.0 0.0017 18.1 0.0 1.6 1 0 0 1 1 1 1 TGS domain AAA_23 PF13476.1 KOH00865.1 - 0.0022 18.3 0.2 0.0066 16.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain FeoB_N PF02421.13 KOH00865.1 - 0.003 16.8 0.0 0.0058 15.9 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B SecA_PP_bind PF01043.15 KOH00865.1 - 0.038 14.3 0.1 0.41 11.0 0.0 2.2 2 0 0 2 2 2 0 SecA preprotein cross-linking domain Cupin_2 PF07883.6 KOH00865.1 - 0.13 11.7 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 Cupin domain MobB PF03205.9 KOH00865.1 - 0.15 11.7 0.5 5.9 6.5 0.0 2.8 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B ADH_zinc_N PF00107.21 KOH00866.1 - 1.7e-07 30.8 0.0 2.8e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CwfJ_C_2 PF04676.9 KOH00866.1 - 0.025 15.0 0.0 0.049 14.1 0.0 1.5 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 2 Pkinase PF00069.20 KOH00867.1 - 2.5e-65 220.2 0.1 4.1e-65 219.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00867.1 - 4.1e-34 117.8 0.0 4.4e-33 114.4 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 KOH00867.1 - 6.1e-06 26.6 0.8 2e-05 24.9 0.5 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 KOH00867.1 - 0.0073 15.2 0.0 0.026 13.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like CTP_transf_1 PF01148.15 KOH00868.1 - 5.9e-81 271.9 23.9 7.3e-81 271.6 16.6 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family DUF3810 PF12725.2 KOH00868.1 - 8.4 5.1 10.5 3.3 6.5 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3810) SET PF00856.23 KOH00869.1 - 1.9e-08 34.8 1.2 3e-05 24.4 0.0 3.1 3 0 0 3 3 3 2 SET domain DDHD PF02862.12 KOH00869.1 - 4.9e-05 23.2 0.7 9.9e-05 22.2 0.5 1.4 1 0 0 1 1 1 1 DDHD domain Nop14 PF04147.7 KOH00869.1 - 0.0012 16.8 15.2 0.0018 16.3 10.6 1.3 1 0 0 1 1 1 1 Nop14-like family Spore_coat_CotO PF14153.1 KOH00869.1 - 0.043 13.2 5.9 0.084 12.3 4.1 1.5 1 0 0 1 1 1 0 Spore coat protein CotO CDC45 PF02724.9 KOH00869.1 - 2 6.3 17.1 0.0042 15.2 4.5 1.8 3 0 0 3 3 3 0 CDC45-like protein Ribosomal_L4 PF00573.17 KOH00870.1 - 4.4e-46 156.6 1.1 8.5e-46 155.7 0.8 1.5 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 KOH00870.1 - 3.2e-29 100.6 0.4 4.5e-28 96.9 0.2 2.3 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Sld5 PF05916.6 KOH00871.1 - 3.6e-12 46.5 1.1 5.4e-12 45.9 0.8 1.3 1 0 0 1 1 1 1 GINS complex protein PIF1 PF05970.9 KOH00871.1 - 0.0017 17.3 0.3 0.0087 15.0 0.0 1.8 1 1 1 2 2 2 1 PIF1-like helicase GCOM2 PF15328.1 KOH00871.1 - 0.023 14.4 1.5 0.04 13.6 1.1 1.4 1 1 0 1 1 1 0 Putative GRINL1B complex locus protein 2 PAH PF02671.16 KOH00871.1 - 0.76 9.4 3.0 0.59 9.7 0.3 2.1 2 0 0 2 2 2 0 Paired amphipathic helix repeat Syntaxin_2 PF14523.1 KOH00871.1 - 3.4 7.7 7.7 7.8 6.5 0.1 2.5 2 1 0 3 3 3 0 Syntaxin-like protein DUF3636 PF12331.3 KOH00872.1 - 0.052 13.1 0.2 0.49 9.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3636) CRCB PF02537.10 KOH00873.1 - 1.1e-31 109.0 25.1 4.3e-22 78.2 5.5 2.8 2 1 0 2 2 2 2 CrcB-like protein DASH_Dad1 PF08649.5 KOH00875.1 - 6.2e-28 96.2 1.5 8.3e-28 95.8 1.1 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad1 GCR1_C PF12550.3 KOH00875.1 - 0.061 13.2 0.3 0.93 9.4 0.0 2.3 1 1 1 2 2 2 0 Transcriptional activator of glycolytic enzymes IPK PF03770.11 KOH00876.1 - 3.4e-49 167.1 0.0 3.4e-49 167.1 0.0 2.2 2 1 0 2 2 2 1 Inositol polyphosphate kinase Bacteriocin_IIi PF11758.3 KOH00876.1 - 0.08 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Aureocin-like type II bacteriocin Acyltransferase PF01553.16 KOH00877.1 - 7.4e-31 106.3 0.0 1.1e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase DUF4328 PF14219.1 KOH00877.1 - 0.0053 16.0 0.0 0.0098 15.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4328) Oxidored_q4 PF00507.14 KOH00877.1 - 0.039 13.7 0.2 0.039 13.7 0.1 2.0 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 GCV_T PF01571.16 KOH00878.1 - 2e-64 216.8 0.0 2.6e-64 216.4 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 KOH00878.1 - 3e-14 52.7 0.0 5.6e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain TrmE_N PF10396.4 KOH00878.1 - 0.012 15.5 0.0 0.46 10.4 0.0 2.3 2 0 0 2 2 2 0 GTP-binding protein TrmE N-terminus PRK PF00485.13 KOH00879.1 - 7.7e-12 45.1 1.7 7.7e-12 45.1 1.2 1.4 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family DUF211 PF02680.9 KOH00879.1 - 0.093 12.5 0.3 0.22 11.3 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 XH PF03469.9 KOH00879.1 - 0.11 12.1 0.1 0.23 11.1 0.0 1.5 1 1 0 1 1 1 0 XH domain DEAD PF00270.24 KOH00880.1 - 7.3e-43 145.9 4.1 1.6e-42 144.8 2.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOH00880.1 - 2.2e-27 94.7 0.8 1.3e-26 92.2 0.2 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 KOH00880.1 - 1.7e-05 24.9 1.1 6.8e-05 23.0 0.8 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOH00880.1 - 2.8e-05 23.7 0.3 0.0001 21.9 0.1 2.0 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 KOH00880.1 - 0.00098 18.7 0.1 0.0021 17.7 0.1 1.5 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 KOH00880.1 - 0.0021 17.3 4.0 0.0021 17.3 2.7 1.7 2 1 0 2 2 2 1 PhoH-like protein CMS1 PF14617.1 KOH00880.1 - 0.0032 16.5 0.8 0.011 14.8 0.0 2.2 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.9 KOH00880.1 - 0.0047 16.5 0.0 0.01 15.5 0.0 1.6 1 1 0 1 1 1 1 Helicase ResIII PF04851.10 KOH00880.1 - 0.014 15.2 1.5 0.041 13.7 0.2 2.3 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 KOH00880.1 - 0.02 14.8 0.2 0.17 11.8 0.1 2.6 2 2 1 3 3 3 0 Helicase C-terminal domain AAA PF00004.24 KOH00880.1 - 0.023 14.8 1.1 0.11 12.7 0.8 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Flavi_DEAD PF07652.9 KOH00880.1 - 0.055 13.2 0.0 0.36 10.5 0.0 2.2 1 1 0 1 1 1 0 Flavivirus DEAD domain CobA_CobO_BtuR PF02572.10 KOH00880.1 - 0.07 12.7 0.2 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Atg31 PF09795.4 KOH00881.1 - 2.1e-51 173.8 7.2 2.4e-51 173.6 5.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 31 tRNA-synt_2b PF00587.20 KOH00882.1 - 9.9e-35 119.6 0.5 2.5e-34 118.3 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 KOH00882.1 - 3.2e-23 81.8 9.7 3.2e-23 81.8 6.7 1.9 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain Mitofilin PF09731.4 KOH00882.1 - 0.03 12.9 5.7 0.044 12.4 3.9 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF342 PF03961.8 KOH00882.1 - 0.036 12.4 6.2 0.058 11.7 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Ribosomal_S17 PF00366.15 KOH00883.1 - 3.3e-30 103.9 5.7 5.4e-30 103.2 3.9 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 Myb_DNA-binding PF00249.26 KOH00884.1 - 5.1e-18 64.8 14.5 3.2e-10 39.9 0.7 4.9 4 1 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOH00884.1 - 1.6e-17 63.3 14.5 4.4e-14 52.3 1.3 4.1 3 2 0 3 3 3 3 Myb-like DNA-binding domain ELYS PF13934.1 KOH00884.1 - 0.03 14.0 0.1 0.057 13.1 0.1 1.4 1 0 0 1 1 1 0 Nuclear pore complex assembly Vps54 PF07928.7 KOH00885.1 - 0.00035 20.6 0.7 0.00096 19.2 0.0 2.2 2 0 0 2 2 2 1 Vps54-like protein DUF1752 PF08550.5 KOH00886.1 - 6.1e-11 41.7 1.6 1.3e-10 40.6 1.1 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) WD40 PF00400.27 KOH00887.1 - 6.8e-19 66.9 10.8 6.2e-06 25.8 0.1 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat CHCH PF06747.8 KOH00888.1 - 7.4e-11 41.6 7.9 6.8e-07 29.0 0.3 2.7 2 1 0 2 2 2 2 CHCH domain UPF0203 PF05254.7 KOH00888.1 - 6.2e-05 22.7 7.9 0.0029 17.4 0.7 3.1 1 1 2 3 3 3 3 Uncharacterised protein family (UPF0203) GCK PF07802.6 KOH00888.1 - 0.0012 18.8 4.5 0.072 13.2 0.1 2.5 1 1 2 3 3 3 3 GCK domain Cmc1 PF08583.5 KOH00888.1 - 0.0017 18.0 6.9 0.047 13.4 0.8 2.8 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like COX6B PF02297.12 KOH00888.1 - 0.0048 16.8 4.9 0.27 11.2 2.8 2.1 1 1 1 2 2 2 1 Cytochrome oxidase c subunit VIb UCR_hinge PF02320.11 KOH00888.1 - 0.008 16.0 5.1 0.022 14.6 0.3 2.3 1 1 0 2 2 2 1 Ubiquinol-cytochrome C reductase hinge protein Pet191_N PF10203.4 KOH00888.1 - 0.029 14.4 8.9 0.97 9.5 3.4 2.7 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 NDUF_B7 PF05676.8 KOH00888.1 - 0.036 13.4 6.0 0.086 12.2 0.2 2.6 1 1 2 3 3 3 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) COX17 PF05051.8 KOH00888.1 - 0.33 10.9 7.1 4.5 7.3 0.6 2.8 2 1 1 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) DB PF01682.14 KOH00888.1 - 0.88 9.6 5.7 0.6 10.1 2.0 1.9 1 1 1 2 2 2 0 DB module FMN_red PF03358.10 KOH00889.1 - 2.5e-10 40.0 0.0 3.6e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.20 KOH00889.1 - 3.7e-08 33.4 0.1 9.2e-08 32.1 0.0 1.7 2 0 0 2 2 2 1 Flavodoxin Flavodoxin_2 PF02525.12 KOH00889.1 - 4.9e-05 22.9 0.0 6.2e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Bac_rhodopsin PF01036.13 KOH00890.1 - 4.9e-38 130.6 14.3 6e-38 130.3 9.9 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein Phage_holin_1 PF04531.8 KOH00890.1 - 0.12 12.4 0.8 0.54 10.3 0.1 2.2 2 0 0 2 2 2 0 Bacteriophage holin TSGP1 PF07771.6 KOH00890.1 - 4.5 7.1 6.8 7.2 6.5 4.7 1.3 1 0 0 1 1 1 0 Tick salivary peptide group 1 Fungal_trans_2 PF11951.3 KOH00891.1 - 3.2e-22 78.6 1.6 6.6e-22 77.6 1.1 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOH00891.1 - 6.7e-07 29.1 12.7 1.4e-06 28.1 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DAHP_synth_1 PF00793.15 KOH00892.1 - 1.6e-102 341.8 0.0 1.9e-102 341.6 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family ECH PF00378.15 KOH00893.1 - 5.3e-30 104.3 0.0 9.9e-30 103.4 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 KOH00893.1 - 3.4e-20 72.3 0.5 1.2e-19 70.5 0.1 2.1 3 0 0 3 3 3 1 2-enoyl-CoA Hydratase C-terminal region USP7_C2 PF14533.1 KOH00893.1 - 0.02 14.3 0.1 0.035 13.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal Cytochrome-c551 PF10643.4 KOH00893.1 - 0.1 11.9 0.3 0.26 10.5 0.0 1.9 3 0 0 3 3 3 0 Photosystem P840 reaction-centre cytochrome c-551 tRNA-synt_2 PF00152.15 KOH00894.1 - 2.7e-89 299.2 0.2 4.6e-89 298.4 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KOH00894.1 - 1.9e-12 46.8 0.2 4.9e-12 45.5 0.1 1.8 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 KOH00894.1 - 1.8e-07 30.6 0.0 0.0016 17.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) E1-E2_ATPase PF00122.15 KOH00895.1 - 4.7e-64 215.5 5.9 1e-63 214.4 4.1 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 KOH00895.1 - 2.7e-33 115.0 0.7 2.7e-33 115.0 0.5 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 KOH00895.1 - 5.7e-26 92.2 0.0 1.2e-24 87.9 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOH00895.1 - 6.4e-17 61.3 0.0 1.3e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 KOH00895.1 - 6.4e-16 59.0 0.0 1.5e-15 57.8 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 KOH00895.1 - 1.2e-15 56.6 0.0 2.4e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 KOH00895.1 - 0.00048 19.7 0.8 0.0025 17.4 0.4 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Ribosomal_S10 PF00338.17 KOH00896.1 - 1e-28 99.0 0.0 1.6e-28 98.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e zf-C2H2_4 PF13894.1 KOH00898.1 - 2.8e-06 27.2 13.9 0.0088 16.3 0.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KOH00898.1 - 2.3e-05 24.4 5.3 2.3e-05 24.4 3.7 3.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.21 KOH00898.1 - 0.00043 20.4 17.1 0.00069 19.8 0.3 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type Coprogen_oxidas PF01218.13 KOH00899.1 - 5.1e-132 438.8 0.0 5.8e-132 438.7 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase TFIIS_C PF01096.13 KOH00900.1 - 7.5e-22 76.6 2.1 7.5e-22 76.6 1.5 2.6 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 KOH00900.1 - 5.4e-17 61.1 2.1 1.5e-16 59.7 0.1 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Elf1 PF05129.8 KOH00900.1 - 0.037 13.7 1.1 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Zn_Tnp_IS1595 PF12760.2 KOH00900.1 - 0.045 13.5 4.3 0.96 9.3 0.3 2.6 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zf-C4_Topoisom PF01396.14 KOH00900.1 - 0.13 11.8 0.6 0.13 11.8 0.4 2.4 3 0 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger Terminase_GpA PF05876.7 KOH00900.1 - 0.16 10.3 0.6 1.1 7.5 0.4 2.0 1 1 0 1 1 1 0 Phage terminase large subunit (GpA) Baculo_LEF5_C PF11792.3 KOH00900.1 - 0.34 10.3 0.1 0.34 10.3 0.1 2.0 3 0 0 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain Desulfoferrod_N PF06397.7 KOH00900.1 - 0.37 10.2 0.2 0.37 10.2 0.1 2.0 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain IBR PF01485.16 KOH00900.1 - 0.7 9.8 7.2 1.7 8.5 0.1 2.9 2 1 0 2 2 2 0 IBR domain Zn-ribbon_8 PF09723.5 KOH00900.1 - 1.3 9.0 9.5 24 4.9 0.1 4.1 4 0 0 4 4 4 0 Zinc ribbon domain PhnA_Zn_Ribbon PF08274.7 KOH00900.1 - 7.1 6.5 7.7 6.4 6.6 0.2 3.1 3 0 0 3 3 3 0 PhnA Zinc-Ribbon zinc_ribbon_2 PF13240.1 KOH00900.1 - 9.6 5.8 10.3 6.4 6.3 0.0 3.5 4 0 0 4 4 4 0 zinc-ribbon domain AA_permease PF00324.16 KOH00901.1 - 4.6e-130 434.1 35.3 5.8e-130 433.8 24.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOH00901.1 - 1.6e-33 115.9 35.3 2.1e-33 115.5 24.5 1.1 1 0 0 1 1 1 1 Amino acid permease URO-D PF01208.12 KOH00902.1 - 4.1e-123 410.6 0.0 4.6e-123 410.4 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Ank_5 PF13857.1 KOH00903.1 - 5.7e-05 23.2 0.0 0.00028 21.0 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOH00903.1 - 0.0097 16.2 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOH00903.1 - 0.078 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeat zf-C2H2_jaz PF12171.3 KOH00903.1 - 0.25 11.5 1.5 0.5 10.5 0.3 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding TIM PF00121.13 KOH00904.1 - 2.3e-88 295.3 0.0 2.6e-88 295.1 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase His_Phos_1 PF00300.17 KOH00905.1 - 9.8e-36 123.2 0.0 1.4e-35 122.7 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Dfp1_Him1_M PF08630.5 KOH00906.1 - 3.7e-46 155.9 0.0 3.7e-46 155.9 0.0 2.6 3 0 0 3 3 3 1 Dfp1/Him1, central region zf-DBF PF07535.7 KOH00906.1 - 1.1e-21 76.2 0.6 2.5e-21 75.0 0.4 1.7 1 0 0 1 1 1 1 DBF zinc finger HHH_8 PF14716.1 KOH00906.1 - 0.0019 18.3 0.1 0.0074 16.4 0.1 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix domain UQ_con PF00179.21 KOH00907.1 - 1.2e-44 151.1 0.1 1.6e-44 150.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOH00907.1 - 0.042 13.6 0.0 0.14 11.9 0.0 1.8 1 1 0 1 1 1 0 Prokaryotic E2 family B Recep_L_domain PF01030.19 KOH00908.1 - 3.4e-08 33.4 18.3 0.00048 20.0 0.6 4.5 1 1 3 4 4 4 4 Receptor L domain LRR_9 PF14580.1 KOH00908.1 - 0.0009 18.8 0.2 0.0025 17.4 0.1 1.9 1 1 0 1 1 1 1 Leucine-rich repeat DUF4339 PF14237.1 KOH00908.1 - 0.015 14.8 0.0 0.11 12.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4339) DUF3242 PF11586.3 KOH00909.1 - 0.0083 15.6 0.3 0.013 15.0 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3242) PFU PF09070.6 KOH00909.1 - 0.0093 15.9 2.7 0.087 12.8 0.1 2.3 2 0 0 2 2 2 1 PFU (PLAA family ubiquitin binding) Myosin_N PF02736.14 KOH00909.1 - 0.014 15.0 0.7 0.04 13.5 0.5 1.8 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain DUF2807 PF10988.3 KOH00909.1 - 0.031 13.8 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2807) PRKCSH PF07915.8 KOH00910.1 - 7.4e-09 36.2 2.3 8.5e-09 36.0 0.3 2.2 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PGAP1 PF07819.8 KOH00911.1 - 6.7e-07 29.1 0.0 1.4e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.9 KOH00911.1 - 3.3e-05 23.2 0.0 7.1e-05 22.1 0.0 1.5 2 0 0 2 2 2 1 Putative serine esterase (DUF676) DUF915 PF06028.6 KOH00911.1 - 0.0022 17.1 0.0 0.016 14.2 0.0 2.3 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_5 PF12695.2 KOH00911.1 - 0.0067 16.1 0.0 0.02 14.6 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOH00911.1 - 0.011 15.6 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family LCAT PF02450.10 KOH00911.1 - 0.011 14.7 0.0 0.021 13.8 0.0 1.4 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF900 PF05990.7 KOH00911.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_1 PF00561.15 KOH00911.1 - 0.037 13.5 0.0 0.068 12.7 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.20 KOH00911.1 - 0.041 13.4 0.0 0.081 12.5 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Oxidored_nitro PF00148.14 KOH00911.1 - 0.15 10.6 0.0 0.21 10.1 0.0 1.1 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase UQ_con PF00179.21 KOH00912.1 - 4.3e-43 146.1 0.1 4.8e-43 145.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOH00912.1 - 2.5e-05 24.0 0.0 2.9e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KOH00912.1 - 0.00071 19.4 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 KOH00912.1 - 0.0049 16.5 0.0 0.0081 15.8 0.0 1.3 1 0 0 1 1 1 1 UEV domain CBF PF03914.12 KOH00913.1 - 2.4e-46 157.1 0.4 2.4e-46 157.1 0.3 3.5 5 0 0 5 5 5 1 CBF/Mak21 family Pyridox_ox_2 PF12900.2 KOH00913.1 - 0.027 14.3 0.1 0.5 10.1 0.0 3.0 3 0 0 3 3 3 0 Pyridoxamine 5'-phosphate oxidase ABC_tran PF00005.22 KOH00914.1 - 4.3e-23 82.1 0.0 7.6e-14 52.1 0.0 2.7 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.1 KOH00914.1 - 1e-08 35.5 3.8 0.00017 21.6 0.0 2.9 2 1 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 KOH00914.1 - 0.00012 21.9 0.0 0.15 12.0 0.0 2.5 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 KOH00914.1 - 0.0014 18.1 0.0 0.003 17.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Miro PF08477.8 KOH00914.1 - 0.0075 16.7 0.0 0.017 15.6 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein AAA_23 PF13476.1 KOH00914.1 - 0.045 14.0 0.2 0.43 10.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 KOH00914.1 - 0.098 12.0 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.1 KOH00914.1 - 0.098 12.6 0.0 0.22 11.4 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain Aminotran_1_2 PF00155.16 KOH00915.1 - 8.5e-72 242.0 0.0 1e-71 241.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOH00915.1 - 0.012 14.7 0.0 0.045 12.9 0.0 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase Aminotran_5 PF00266.14 KOH00915.1 - 0.026 13.2 0.0 0.064 11.9 0.0 1.5 1 1 0 1 1 1 0 Aminotransferase class-V CSS-motif PF12792.2 KOH00915.1 - 0.041 13.2 0.0 0.095 12.0 0.0 1.6 2 0 0 2 2 2 0 CSS motif domain associated with EAL Cofilin_ADF PF00241.15 KOH00916.1 - 1.7e-07 31.1 0.1 2.1e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Ribosomal_S13_N PF08069.7 KOH00917.1 - 2.8e-25 87.9 0.3 5.5e-25 86.9 0.0 1.6 2 0 0 2 2 2 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.17 KOH00917.1 - 1.9e-23 82.0 0.2 4.9e-23 80.7 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein S15 Complex1_LYR PF05347.10 KOH00918.1 - 0.024 14.4 2.4 0.17 11.7 0.6 2.7 2 1 0 2 2 2 0 Complex 1 protein (LYR family) NikR_C PF08753.6 KOH00918.1 - 0.036 13.9 0.1 0.069 13.0 0.1 1.4 1 0 0 1 1 1 0 NikR C terminal nickel binding domain Complex1_LYR_2 PF13233.1 KOH00918.1 - 2.1 8.8 8.4 0.11 13.0 0.6 2.5 2 1 0 2 2 2 0 Complex1_LYR-like RPAP2_Rtr1 PF04181.8 KOH00919.1 - 9.7e-11 41.6 1.3 2.5e-08 33.8 0.9 2.5 1 1 0 1 1 1 1 Rtr1/RPAP2 family Myticin-prepro PF10690.4 KOH00919.1 - 0.093 12.7 0.8 5.9 6.9 0.3 2.3 1 1 1 2 2 2 0 Myticin pre-proprotein from the mussel Y_phosphatase2 PF03162.8 KOH00920.1 - 9e-61 204.0 1.8 1.1e-60 203.7 1.2 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family BSD PF03909.12 KOH00921.1 - 1.4e-15 56.7 0.2 1.4e-15 56.7 0.2 2.4 2 1 0 2 2 2 1 BSD domain DUF1198 PF06711.6 KOH00921.1 - 0.057 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1198) DUF1002 PF06207.6 KOH00921.1 - 0.13 11.6 6.5 0.32 10.3 4.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) DUF4337 PF14235.1 KOH00921.1 - 0.31 10.8 8.1 0.065 13.0 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) UCH PF00443.24 KOH00922.1 - 1.4e-69 234.1 0.6 1.4e-69 234.1 0.4 2.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOH00922.1 - 1.7e-31 109.7 0.3 1.7e-31 109.7 0.2 3.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.15 KOH00922.1 - 0.00016 21.9 0.0 0.00058 20.1 0.0 2.0 1 0 0 1 1 1 1 Rhodanese-like domain Zn-ribbon_8 PF09723.5 KOH00922.1 - 1 9.3 5.2 11 6.0 1.5 2.8 2 0 0 2 2 2 0 Zinc ribbon domain Acetyltransf_1 PF00583.19 KOH00924.1 - 2.4e-09 37.0 0.0 3.8e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOH00924.1 - 2.2e-08 34.1 0.0 3.2e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 KOH00924.1 - 0.0046 16.8 0.0 0.0062 16.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOH00924.1 - 0.0062 16.2 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.1 KOH00924.1 - 0.013 15.3 0.0 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 KOH00924.1 - 0.024 14.5 0.1 0.039 13.9 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOH00924.1 - 0.079 13.0 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PAP2 PF01569.16 KOH00925.1 - 1.1e-09 38.0 13.4 2.9e-09 36.6 4.4 3.1 2 1 0 2 2 2 2 PAP2 superfamily ACP53EA PF06313.6 KOH00926.1 - 0.027 14.4 0.1 0.039 13.8 0.1 1.2 1 0 0 1 1 1 0 Drosophila ACP53EA protein Glyco_transf_20 PF00982.16 KOH00927.1 - 7.9e-157 522.5 4.1 1.1e-156 522.0 2.8 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 KOH00927.1 - 1.5e-89 298.9 0.0 2.5e-89 298.2 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Gon7 PF08738.5 KOH00927.1 - 0.29 11.1 2.9 0.44 10.5 0.0 2.6 3 0 0 3 3 3 0 Gon7 family Metallophos PF00149.23 KOH00928.1 - 1.6e-42 145.1 0.1 2e-42 144.8 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOH00928.1 - 0.00011 22.0 0.0 0.00019 21.3 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain KaiC PF06745.8 KOH00929.1 - 1.2e-07 31.0 0.2 2.7e-07 29.9 0.1 1.7 1 1 0 1 1 1 1 KaiC Rad51 PF08423.6 KOH00929.1 - 5.6e-06 25.4 0.0 9.6e-06 24.6 0.0 1.3 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 KOH00929.1 - 9.2e-06 25.1 0.0 1.7e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOH00929.1 - 0.0021 18.2 0.0 0.004 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOH00929.1 - 0.0033 17.7 0.0 0.011 15.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.10 KOH00929.1 - 0.012 14.5 0.2 0.051 12.4 0.0 2.2 3 0 0 3 3 3 0 DnaB-like helicase C terminal domain Hema_stalk PF08720.5 KOH00929.1 - 0.04 13.4 0.1 0.22 11.0 0.0 2.1 1 1 1 2 2 2 0 Influenza C hemagglutinin stalk DUF3883 PF13020.1 KOH00929.1 - 0.065 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) Fer2_4 PF13510.1 KOH00930.1 - 0.05 13.4 2.6 4.1 7.2 0.1 2.9 2 1 1 3 3 3 0 2Fe-2S iron-sulfur cluster binding domain SWIM PF04434.12 KOH00931.1 - 0.0086 15.5 4.7 1.3 8.5 0.6 2.4 2 0 0 2 2 2 2 SWIM zinc finger DUF3738 PF12543.3 KOH00932.1 - 0.057 12.9 0.1 0.078 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3738) DEK_C PF08766.6 KOH00932.1 - 0.059 13.1 1.0 0.12 12.2 0.7 1.6 1 0 0 1 1 1 0 DEK C terminal domain GvpL_GvpF PF06386.6 KOH00932.1 - 0.12 11.9 0.5 0.15 11.6 0.4 1.0 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Tbf5 PF06331.7 KOH00933.1 - 2.7e-28 97.5 0.3 3.1e-28 97.3 0.2 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Clathrin PF00637.15 KOH00934.1 - 4e-33 114.0 2.6 4e-32 110.7 0.2 2.5 2 0 0 2 2 2 1 Region in Clathrin and VPS WD40 PF00400.27 KOH00934.1 - 5e-05 23.0 0.7 0.0059 16.4 0.3 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat Vps39_1 PF10366.4 KOH00934.1 - 5.9e-05 23.0 0.4 0.00023 21.1 0.0 2.2 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Prp19_bind PF06991.6 KOH00934.1 - 0.23 10.6 5.5 0.51 9.5 3.8 1.5 1 0 0 1 1 1 0 Splicing factor, Prp19-binding domain EBV-NA3 PF05009.7 KOH00934.1 - 3.9 6.6 4.1 8.6 5.5 2.8 1.5 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) DDE_1 PF03184.14 KOH00935.1 - 4.5e-79 264.5 3.0 4.5e-79 264.5 2.1 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KOH00935.1 - 1.1e-14 53.9 0.2 1.1e-14 53.9 0.1 2.5 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain Stn1 PF10451.4 KOH00936.1 - 4.6e-99 330.4 4.3 6.1e-99 330.0 3.0 1.2 1 0 0 1 1 1 1 Telomere regulation protein Stn1 Stn1_C PF12659.2 KOH00936.1 - 6.3e-36 122.9 2.6 6.9e-36 122.8 0.9 1.8 2 0 0 2 2 2 1 Telomere capping C-terminal wHTH Methyltransf_8 PF05148.10 KOH00937.1 - 3.6e-67 226.1 3.1 8.7e-65 218.4 0.1 2.9 1 1 1 2 2 2 2 Hypothetical methyltransferase Methyltransf_11 PF08241.7 KOH00937.1 - 1.7e-09 38.0 0.0 2.2e-07 31.2 0.0 3.3 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOH00937.1 - 8.1e-05 22.2 0.2 0.00074 19.1 0.1 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOH00937.1 - 0.0023 18.2 0.1 0.02 15.2 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.1 KOH00937.1 - 0.055 13.1 0.0 0.055 13.1 0.0 2.5 3 1 0 3 3 3 0 Methyltransferase domain Neur_chan_memb PF02932.11 KOH00937.1 - 0.55 10.0 3.2 0.85 9.4 2.2 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF846 PF05832.7 KOH00938.1 - 5.1e-47 159.1 9.4 6.1e-47 158.8 6.5 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) SecE PF00584.15 KOH00940.1 - 2.1e-10 40.0 0.0 2.4e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Coiled-coil_56 PF09813.4 KOH00940.1 - 0.019 14.9 0.0 0.021 14.8 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 Nop52 PF05997.7 KOH00941.1 - 6.6e-68 228.3 6.7 7.9e-68 228.1 4.7 1.0 1 0 0 1 1 1 1 Nucleolar protein,Nop52 TAN PF11640.3 KOH00941.1 - 0.0028 17.3 0.7 0.013 15.2 0.2 2.1 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair DUF3139 PF11337.3 KOH00941.1 - 0.087 13.1 1.1 0.76 10.0 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) Nucleoplasmin PF03066.10 KOH00941.1 - 0.55 9.7 9.2 0.062 12.8 0.7 2.2 2 0 0 2 2 2 0 Nucleoplasmin CENP-B_dimeris PF09026.5 KOH00941.1 - 2.4 8.4 14.0 1 9.6 2.0 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Slu7 PF11708.3 KOH00942.1 - 4.9e-45 154.1 22.5 4.9e-45 154.1 15.6 2.1 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC PF00098.18 KOH00942.1 - 0.0014 18.4 4.1 0.0022 17.8 2.8 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 KOH00942.1 - 0.1 12.2 0.5 0.25 11.0 0.4 1.6 1 0 0 1 1 1 0 Zinc knuckle SPX PF03105.14 KOH00943.1 - 9e-06 25.6 6.2 9e-06 25.6 4.3 5.0 1 1 2 3 3 3 2 SPX domain DUF3493 PF11998.3 KOH00943.1 - 0.46 10.3 1.9 1 9.3 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3493) ABC2_membrane_3 PF12698.2 KOH00943.1 - 2.6 6.9 16.5 0.16 10.9 5.0 2.6 2 2 0 2 2 2 0 ABC-2 family transporter protein PQ-loop PF04193.9 KOH00944.1 - 7.4e-24 83.0 8.7 1.9e-18 65.7 1.5 2.6 2 0 0 2 2 2 2 PQ loop repeat RLL PF10036.4 KOH00944.1 - 0.024 14.0 1.3 0.034 13.5 0.9 1.1 1 0 0 1 1 1 0 Putative carnitine deficiency-associated protein ABC2_membrane_5 PF13346.1 KOH00944.1 - 0.47 9.6 23.1 0.02 14.1 7.6 2.2 1 1 2 3 3 3 0 ABC-2 family transporter protein ABC_tran PF00005.22 KOH00945.1 - 1.5e-35 122.4 0.0 9.5e-17 61.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RLI PF04068.10 KOH00945.1 - 1.6e-14 53.1 5.0 3.7e-14 52.0 3.5 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.1 KOH00945.1 - 6.4e-14 52.5 8.7 0.0058 16.6 0.0 4.3 2 2 2 4 4 4 4 AAA domain SMC_N PF02463.14 KOH00945.1 - 2.6e-09 36.6 2.4 0.027 13.7 0.0 4.0 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 KOH00945.1 - 1.6e-07 30.7 0.1 0.47 9.4 0.0 4.0 3 1 1 4 4 4 2 AAA ATPase domain Fer4 PF00037.22 KOH00945.1 - 2.9e-07 29.7 3.5 2.9e-07 29.7 2.4 2.5 3 0 0 3 3 2 1 4Fe-4S binding domain AAA PF00004.24 KOH00945.1 - 1.3e-06 28.5 0.0 0.0053 16.9 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 KOH00945.1 - 6.5e-06 25.5 0.3 0.13 11.7 0.0 2.7 3 0 0 3 3 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 KOH00945.1 - 1e-05 24.7 2.5 0.042 13.0 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOH00945.1 - 2.8e-05 24.2 0.0 0.014 15.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KOH00945.1 - 2.9e-05 24.8 0.2 0.14 12.9 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 KOH00945.1 - 0.00013 21.9 0.0 0.027 14.4 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Miro PF08477.8 KOH00945.1 - 0.00018 21.9 0.0 0.43 11.0 0.0 2.7 3 0 0 3 3 2 1 Miro-like protein NB-ARC PF00931.17 KOH00945.1 - 0.00023 20.1 0.0 0.065 12.0 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain Fer4_6 PF12837.2 KOH00945.1 - 0.00024 20.8 12.2 0.00038 20.2 2.3 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_18 PF13238.1 KOH00945.1 - 0.00047 20.4 0.0 1.2 9.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 KOH00945.1 - 0.00097 18.8 0.4 0.25 11.0 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 KOH00945.1 - 0.00098 19.0 0.2 0.85 9.5 0.0 2.9 3 0 0 3 3 2 1 AAA domain NACHT PF05729.7 KOH00945.1 - 0.001 18.7 1.5 0.11 12.1 0.0 2.5 2 0 0 2 2 2 1 NACHT domain Fer4_21 PF14697.1 KOH00945.1 - 0.0013 18.5 12.7 0.0028 17.4 8.8 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.2 KOH00945.1 - 0.0017 18.7 1.8 0.0017 18.7 1.3 2.5 1 1 0 2 2 2 1 4Fe-4S dicluster domain AAA_25 PF13481.1 KOH00945.1 - 0.0017 17.7 0.0 1 8.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 KOH00945.1 - 0.002 18.3 0.1 0.79 9.9 0.0 3.0 4 0 0 4 4 2 1 RNA helicase Rad17 PF03215.10 KOH00945.1 - 0.0026 16.5 0.0 1.2 7.7 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein Fer4_2 PF12797.2 KOH00945.1 - 0.0026 17.5 2.4 0.0026 17.5 1.7 2.6 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_33 PF13671.1 KOH00945.1 - 0.003 17.4 0.0 0.42 10.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4_9 PF13187.1 KOH00945.1 - 0.004 17.3 2.2 0.004 17.3 1.6 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain AAA_28 PF13521.1 KOH00945.1 - 0.0044 16.9 0.0 1.1 9.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain VirE PF05272.6 KOH00945.1 - 0.0045 16.4 0.0 0.61 9.5 0.0 2.3 2 0 0 2 2 2 1 Virulence-associated protein E SRP54 PF00448.17 KOH00945.1 - 0.0049 16.3 2.8 0.21 11.0 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_16 PF13484.1 KOH00945.1 - 0.0055 17.4 0.1 0.0055 17.4 0.1 2.5 2 1 1 3 3 1 1 4Fe-4S double cluster binding domain Fer4_3 PF12798.2 KOH00945.1 - 0.0058 17.1 4.2 0.0058 17.1 2.9 2.5 2 0 0 2 2 1 1 4Fe-4S binding domain Fer4_10 PF13237.1 KOH00945.1 - 0.0068 16.1 1.5 0.0068 16.1 1.0 2.2 1 1 1 2 2 2 1 4Fe-4S dicluster domain AAA_23 PF13476.1 KOH00945.1 - 0.0073 16.6 4.5 0.038 14.3 0.0 2.7 2 1 0 2 2 2 1 AAA domain SbcCD_C PF13558.1 KOH00945.1 - 0.01 15.7 0.0 12 5.9 0.0 3.5 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit UPF0079 PF02367.12 KOH00945.1 - 0.012 15.2 0.2 0.16 11.6 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 KOH00945.1 - 0.012 15.1 0.1 0.29 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 KOH00945.1 - 0.017 14.8 1.6 0.11 12.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Fer4_4 PF12800.2 KOH00945.1 - 0.042 14.2 2.2 0.042 14.2 1.5 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Thymidylate_kin PF02223.12 KOH00945.1 - 0.054 12.8 0.7 8.6 5.6 0.0 3.1 3 0 0 3 3 3 0 Thymidylate kinase AAA_24 PF13479.1 KOH00945.1 - 0.077 12.5 0.4 1.9 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.8 KOH00945.1 - 0.093 11.6 0.0 3.6 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Fer4_17 PF13534.1 KOH00945.1 - 0.098 13.0 0.2 0.098 13.0 0.1 2.6 2 0 0 2 2 2 0 4Fe-4S dicluster domain DLIC PF05783.6 KOH00945.1 - 0.17 10.4 0.0 0.29 9.7 0.0 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) PduV-EutP PF10662.4 KOH00945.1 - 0.18 11.2 1.9 0.36 10.3 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_13 PF13166.1 KOH00945.1 - 0.19 10.1 0.1 0.99 7.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain ArgK PF03308.11 KOH00945.1 - 0.19 10.4 0.1 3.1 6.4 0.0 2.1 2 0 0 2 2 2 0 ArgK protein AAA_19 PF13245.1 KOH00945.1 - 0.2 11.4 0.9 0.66 9.7 0.0 2.1 2 0 0 2 2 1 0 Part of AAA domain NTPase_1 PF03266.10 KOH00945.1 - 0.21 11.2 1.5 2.5 7.8 0.1 2.4 2 0 0 2 2 2 0 NTPase Fer4_8 PF13183.1 KOH00945.1 - 0.23 11.5 8.6 0.12 12.4 0.8 1.9 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.1 KOH00945.1 - 8.9 6.8 10.4 0.35 11.3 2.5 2.0 1 1 0 2 2 1 0 4Fe-4S dicluster domain E1-E2_ATPase PF00122.15 KOH00946.1 - 1.1e-16 60.6 0.0 2.5e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 KOH00946.1 - 3.7e-13 50.0 0.1 7.8e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOH00946.1 - 7.9e-13 48.1 0.0 2.2e-12 46.7 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase PF00702.21 KOH00946.1 - 5.6e-10 40.0 1.6 1.9e-05 25.2 1.1 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KOH00946.1 - 0.0013 18.4 0.2 0.0037 16.8 0.1 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase JmjC PF02373.17 KOH00947.1 - 1.2e-32 112.5 2.0 1.4e-32 112.3 0.2 2.2 2 0 0 2 2 2 1 JmjC domain, hydroxylase JmjN PF02375.12 KOH00947.1 - 2.3e-11 43.0 2.1 3.2e-11 42.5 0.5 2.0 2 0 0 2 2 2 1 jmjN domain zf-C2H2 PF00096.21 KOH00947.1 - 1.5e-06 28.2 16.5 0.003 17.7 2.5 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOH00947.1 - 1.5e-06 28.1 13.6 0.0016 18.6 1.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KOH00947.1 - 3.7e-06 26.9 6.2 3.7e-06 26.9 4.3 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.1 KOH00947.1 - 0.00022 21.0 9.5 0.0054 16.6 2.4 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 KOH00947.1 - 0.063 13.4 7.4 1.9 8.8 0.3 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KOH00947.1 - 0.18 11.9 9.7 0.7 10.1 2.9 2.6 1 1 1 2 2 2 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.5 KOH00947.1 - 1.6 8.7 5.4 8.2 6.4 3.7 2.1 1 1 0 1 1 1 0 Zinc ribbon domain MutS_V PF00488.16 KOH00948.1 - 6.5e-75 251.5 0.1 1.4e-74 250.4 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 KOH00948.1 - 6.3e-43 146.9 0.2 1.2e-42 146.0 0.2 1.5 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 KOH00948.1 - 1.6e-33 115.0 0.0 5.2e-33 113.4 0.0 1.9 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.13 KOH00948.1 - 9.5e-19 67.3 0.6 2.9e-18 65.8 0.4 1.9 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.12 KOH00948.1 - 6.3e-12 45.7 0.7 2.1e-11 44.0 0.0 2.2 2 0 0 2 2 2 1 MutS domain II AAA_29 PF13555.1 KOH00948.1 - 0.052 13.0 0.0 0.16 11.5 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.22 KOH00948.1 - 0.053 13.8 3.5 4.1 7.7 0.0 3.9 3 0 0 3 3 3 0 ABC transporter Glutaredoxin PF00462.19 KOH00949.1 - 2.7e-19 68.9 0.0 5.1e-16 58.4 0.0 2.6 2 0 0 2 2 2 2 Glutaredoxin Thioredoxin PF00085.15 KOH00949.1 - 4.5e-15 55.2 0.0 1e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 KOH00949.1 - 1.1e-05 25.4 0.1 0.0028 17.7 0.0 2.6 1 1 1 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.16 KOH00949.1 - 0.00052 19.7 0.0 0.00091 18.9 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Nucleoplasmin PF03066.10 KOH00949.1 - 0.0015 18.0 2.6 0.0019 17.7 1.8 1.3 1 0 0 1 1 1 1 Nucleoplasmin Thioredoxin_2 PF13098.1 KOH00949.1 - 0.0019 18.3 0.1 0.066 13.4 0.0 2.8 2 2 0 2 2 2 1 Thioredoxin-like domain TRAP_alpha PF03896.11 KOH00949.1 - 0.0038 16.2 0.9 0.005 15.8 0.7 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Thioredoxin_7 PF13899.1 KOH00949.1 - 0.0099 15.8 0.0 0.034 14.1 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin-like CENP-B_dimeris PF09026.5 KOH00949.1 - 0.015 15.5 5.2 0.03 14.5 3.6 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CPSF73-100_C PF11718.3 KOH00949.1 - 0.029 13.7 2.5 0.92 8.8 0.0 2.1 2 0 0 2 2 2 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term DUF2457 PF10446.4 KOH00949.1 - 0.064 11.9 4.6 0.087 11.5 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RNase_H2_suC PF08615.6 KOH00949.1 - 0.078 12.8 0.1 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Sigma70_ner PF04546.8 KOH00949.1 - 0.079 12.5 5.6 0.12 11.9 3.9 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region CobT PF06213.7 KOH00949.1 - 0.12 11.5 5.2 0.18 10.9 3.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DIM1 PF02966.11 KOH00949.1 - 0.13 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Mitosis protein DIM1 FAM176 PF14851.1 KOH00949.1 - 0.13 11.9 1.8 0.21 11.2 1.2 1.3 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.6 KOH00949.1 - 0.18 11.6 3.4 0.29 10.9 2.4 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Myc_N PF01056.13 KOH00949.1 - 0.48 9.5 4.5 0.7 9.0 3.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Sporozoite_P67 PF05642.6 KOH00949.1 - 0.58 7.9 2.9 0.75 7.5 2.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Daxx PF03344.10 KOH00949.1 - 0.9 7.9 7.5 1.1 7.6 5.2 1.1 1 0 0 1 1 1 0 Daxx Family PBP1_TM PF14812.1 KOH00949.1 - 1.5 9.1 6.4 2.5 8.4 4.4 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.8 KOH00949.1 - 2.7 5.6 7.9 3.8 5.1 5.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.7 KOH00949.1 - 4.7 6.3 5.6 6.8 5.8 3.9 1.2 1 0 0 1 1 1 0 NOA36 protein 14-3-3 PF00244.15 KOH00950.1 - 1.7e-115 384.0 4.7 2.2e-115 383.7 3.3 1.1 1 0 0 1 1 1 1 14-3-3 protein DUF885 PF05960.6 KOH00950.1 - 0.0073 15.5 1.1 0.0073 15.5 0.8 1.9 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF885) FlaF PF07309.6 KOH00950.1 - 0.019 14.8 0.7 0.062 13.1 0.5 1.8 1 0 0 1 1 1 0 Flagellar protein FlaF COPI_assoc PF08507.5 KOH00951.1 - 9.4e-38 129.0 4.3 1e-37 128.8 3.0 1.0 1 0 0 1 1 1 1 COPI associated protein Peptidase_M24 PF00557.19 KOH00952.1 - 2.7e-09 36.9 0.0 1.2e-08 34.7 0.0 2.1 2 0 0 2 2 2 1 Metallopeptidase family M24 Ste5_C PF12194.3 KOH00953.1 - 9.5e-85 283.0 5.3 1.7e-84 282.2 3.7 1.4 1 0 0 1 1 1 1 Protein kinase Fus3-binding Ste5 PF11610.3 KOH00953.1 - 6.7e-19 67.1 2.4 1.3e-18 66.2 1.7 1.5 1 0 0 1 1 1 1 Scaffold protein Ste5-Fus5 binding region zf-RING_2 PF13639.1 KOH00953.1 - 8.5e-05 22.3 2.5 0.00017 21.3 1.7 1.5 1 0 0 1 1 1 1 Ring finger domain PH_10 PF15411.1 KOH00953.1 - 0.019 15.1 0.1 0.048 13.8 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain PH_4 PF15404.1 KOH00954.1 - 5.8e-71 237.8 0.0 1.2e-70 236.8 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Spo7_2_N PF15407.1 KOH00954.1 - 8.3e-27 92.4 0.2 2.5e-26 90.9 0.1 1.9 1 0 0 1 1 1 1 Sporulation protein family 7 PH PF00169.24 KOH00954.1 - 2.8e-06 27.4 1.0 0.023 14.8 0.0 4.2 3 1 0 3 3 3 2 PH domain Serinc PF03348.10 KOH00955.1 - 3.3e-155 517.0 16.4 3.8e-155 516.8 11.4 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) Orbi_NS3 PF01616.11 KOH00955.1 - 1.8 7.5 4.4 10 5.0 2.9 2.4 1 1 0 1 1 1 0 Orbivirus NS3 Actin PF00022.14 KOH00956.1 - 1.2e-10 40.3 0.0 1.4e-08 33.6 0.0 2.3 2 1 0 2 2 2 2 Actin EMP70 PF02990.11 KOH00957.1 - 1.7e-208 693.3 13.0 2.4e-208 692.8 9.0 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 TRAPPC-Trs85 PF12739.2 KOH00958.1 - 1.9e-101 339.7 1.6 1.9e-101 339.7 1.1 1.6 2 0 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Acyl-thio_N PF12590.3 KOH00958.1 - 0.061 13.7 0.6 0.17 12.3 0.0 2.0 2 0 0 2 2 2 0 Acyl-ATP thioesterase Aminotran_1_2 PF00155.16 KOH00960.1 - 8e-37 127.0 0.0 1.2e-36 126.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOH00960.1 - 0.11 11.6 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase Securin PF04856.8 KOH00961.1 - 2.2e-52 178.0 10.8 2.7e-52 177.8 7.5 1.1 1 0 0 1 1 1 1 Securin sister-chromatid separation inhibitor Ribosomal_L34 PF00468.12 KOH00962.1 - 3e-19 68.4 5.3 3e-19 68.4 3.7 1.7 1 1 1 2 2 2 1 Ribosomal protein L34 Ribosomal_L1 PF00687.16 KOH00963.1 - 2e-21 76.3 0.1 2.4e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family SUI1 PF01253.17 KOH00964.1 - 2.1e-13 49.8 0.2 2.1e-13 49.8 0.2 2.5 3 0 0 3 3 3 1 Translation initiation factor SUI1 SWIB PF02201.13 KOH00964.1 - 0.00023 20.7 1.2 0.00038 20.0 0.2 1.9 2 0 0 2 2 2 1 SWIB/MDM2 domain MCPsignal PF00015.16 KOH00964.1 - 0.036 13.6 1.3 0.068 12.6 0.9 1.3 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain P2 PF07194.6 KOH00964.1 - 3.4 7.5 8.2 3.3 7.6 3.3 2.4 2 0 0 2 2 2 0 P2 response regulator binding domain Apc4 PF12896.2 KOH00965.1 - 6.3e-26 90.9 0.6 1.2e-25 90.0 0.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 Apc4_WD40 PF12894.2 KOH00965.1 - 2e-07 30.3 0.6 4.4e-07 29.3 0.0 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain MFS_1 PF07690.11 KOH00966.1 - 4.2e-22 78.3 41.7 3.1e-21 75.5 11.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily TRM PF02005.11 KOH00968.1 - 6.8e-153 509.0 0.1 7.9e-153 508.8 0.1 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.11 KOH00968.1 - 8.7e-06 25.4 0.1 1.5e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.10 KOH00968.1 - 0.019 14.3 0.0 0.046 13.1 0.0 1.7 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_16 PF10294.4 KOH00968.1 - 0.041 13.3 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase CpXC PF14353.1 KOH00968.1 - 0.063 13.2 0.0 0.22 11.4 0.0 1.9 1 0 0 1 1 1 0 CpXC protein MTS PF05175.9 KOH00968.1 - 0.072 12.4 0.1 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain CBFD_NFYB_HMF PF00808.18 KOH00969.1 - 0.0017 18.4 0.4 0.0033 17.4 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pkinase PF00069.20 KOH00970.1 - 5.1e-71 238.8 3.1 2.1e-70 236.8 1.3 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH00970.1 - 8.8e-42 142.9 0.9 8.1e-40 136.5 0.6 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.14 KOH00970.1 - 1.3e-20 72.5 0.1 2.6e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.1 KOH00970.1 - 7e-06 25.2 0.0 1.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOH00970.1 - 0.00029 19.9 0.1 0.00055 19.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOH00970.1 - 0.0021 17.8 0.0 0.11 12.1 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family HLH PF00010.21 KOH00971.1 - 0.014 15.1 0.6 0.025 14.2 0.4 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain DUF2841 PF11001.3 KOH00972.1 - 5e-36 123.3 1.9 9e-36 122.5 1.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) ALMT PF11744.3 KOH00972.1 - 0.011 14.4 0.1 0.014 14.0 0.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Cnd1 PF12717.2 KOH00972.1 - 0.026 14.3 0.3 0.04 13.7 0.2 1.3 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Abhydrolase_6 PF12697.2 KOH00973.1 - 5.2e-18 65.7 0.0 7.4e-18 65.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOH00973.1 - 2.3e-16 60.0 0.0 5.2e-15 55.6 0.0 2.3 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOH00973.1 - 2.5e-09 37.0 0.0 5.1e-09 36.0 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.6 KOH00973.1 - 1.3e-05 24.4 0.1 0.016 14.3 0.0 2.5 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.15 KOH00973.1 - 0.0014 18.1 0.0 0.0026 17.2 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.9 KOH00973.1 - 0.0058 15.1 0.0 0.085 11.3 0.0 2.2 2 0 0 2 2 2 1 Ndr family Peptidase_S9 PF00326.16 KOH00973.1 - 0.0071 15.5 0.0 1.1 8.4 0.0 2.6 3 0 0 3 3 3 1 Prolyl oligopeptidase family Ser_hydrolase PF06821.8 KOH00973.1 - 0.01 15.4 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Abhydrolase_3 PF07859.8 KOH00973.1 - 0.014 15.0 0.0 0.59 9.6 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.2 KOH00973.1 - 0.093 11.6 0.0 0.3 9.9 0.0 1.8 2 0 0 2 2 2 0 Chlorophyllase enzyme zf-DHHC PF01529.15 KOH00974.1 - 2.6e-26 92.0 16.2 2.6e-26 92.0 11.3 2.3 1 1 1 2 2 2 1 DHHC palmitoyltransferase DUF936 PF06075.7 KOH00974.1 - 0.0055 15.7 0.2 0.0076 15.2 0.2 1.1 1 0 0 1 1 1 1 Plant protein of unknown function (DUF936) EPSP_synthase PF00275.15 KOH00975.1 - 3e-146 487.1 0.0 4.8e-146 486.4 0.0 1.3 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.15 KOH00975.1 - 7.2e-98 326.6 0.1 1.2e-97 325.9 0.0 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.10 KOH00975.1 - 1e-66 224.7 0.0 2e-66 223.8 0.0 1.5 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.17 KOH00975.1 - 3.7e-37 127.6 0.0 1.1e-36 126.1 0.0 1.8 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.6 KOH00975.1 - 1.5e-22 79.4 0.1 1.5e-21 76.2 0.0 2.6 3 0 0 3 3 3 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.15 KOH00975.1 - 7.1e-19 68.2 0.0 2.4e-18 66.5 0.0 1.9 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_17 PF13207.1 KOH00975.1 - 9.2e-07 29.7 0.0 3.2e-06 27.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain Fe-ADH_2 PF13685.1 KOH00975.1 - 1.2e-05 24.7 0.0 2.5e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase AAA_33 PF13671.1 KOH00975.1 - 0.00019 21.2 0.0 0.0007 19.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 KOH00975.1 - 0.0086 15.9 0.1 0.052 13.4 0.0 2.3 3 0 0 3 3 3 1 AAA domain 6PF2K PF01591.13 KOH00975.1 - 0.04 12.9 0.0 0.078 12.0 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase ThiF PF00899.16 KOH00975.1 - 0.068 12.9 0.0 0.27 11.0 0.0 2.0 1 0 0 1 1 1 0 ThiF family AAA_18 PF13238.1 KOH00975.1 - 0.082 13.2 0.2 0.83 9.9 0.0 2.7 3 0 0 3 3 3 0 AAA domain WD40 PF00400.27 KOH00976.1 - 2.9e-14 52.2 21.8 5.5e-07 29.2 0.2 6.1 7 0 0 7 7 7 3 WD domain, G-beta repeat zf-rbx1 PF12678.2 KOH00976.1 - 0.0074 16.3 4.5 0.019 15.0 3.1 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 KOH00976.1 - 0.039 13.9 10.5 0.11 12.5 7.3 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RWD PF05773.17 KOH00976.1 - 0.044 13.6 0.2 0.12 12.2 0.1 1.7 1 0 0 1 1 1 0 RWD domain zf-RING_2 PF13639.1 KOH00976.1 - 0.069 12.9 7.2 0.17 11.7 5.0 1.7 1 0 0 1 1 1 0 Ring finger domain C1_3 PF07649.7 KOH00976.1 - 0.41 10.7 8.3 0.79 9.8 2.6 2.6 2 0 0 2 2 2 0 C1-like domain zf-RING_5 PF14634.1 KOH00976.1 - 0.52 10.0 10.1 1.3 8.7 7.0 1.7 1 0 0 1 1 1 0 zinc-RING finger domain CH PF00307.26 KOH00977.1 - 5e-55 184.1 0.1 3.7e-21 75.1 0.1 3.1 3 0 0 3 3 3 3 Calponin homology (CH) domain CAMSAP_CH PF11971.3 KOH00977.1 - 1.6e-05 24.4 0.0 0.15 11.7 0.0 3.1 3 0 0 3 3 3 2 CAMSAP CH domain BTB_2 PF02214.17 KOH00980.1 - 2.8e-10 40.2 0.3 5.9e-06 26.4 0.1 3.0 2 1 0 2 2 2 2 BTB/POZ domain Flocculin_t3 PF13928.1 KOH00981.1 - 6.1e-15 55.0 17.3 6.1e-15 55.0 12.0 2.7 3 0 0 3 3 3 1 Flocculin type 3 repeat Mucin PF01456.12 KOH00981.1 - 1 9.1 23.1 1.3 8.7 16.0 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Gram_pos_anchor PF00746.16 KOH00981.1 - 7.1 6.5 10.7 1 9.2 2.7 2.3 2 0 0 2 2 2 0 Gram positive anchor ABC_membrane PF00664.18 KOH00982.1 - 1.5e-97 326.3 30.4 1.2e-60 205.3 4.0 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 KOH00982.1 - 7e-48 162.4 0.2 3.3e-29 101.9 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.1 KOH00982.1 - 1.7e-08 34.6 0.2 0.002 18.1 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 KOH00982.1 - 4.7e-08 32.5 6.6 0.0013 18.0 0.6 4.1 2 2 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 KOH00982.1 - 1.9e-06 27.4 0.2 0.075 12.4 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 KOH00982.1 - 0.00019 21.8 1.5 0.15 12.3 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.1 KOH00982.1 - 0.0003 20.2 1.0 0.65 9.5 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Miro PF08477.8 KOH00982.1 - 0.0015 19.0 1.6 1.6 9.2 0.0 3.1 3 0 0 3 3 2 2 Miro-like protein MMR_HSR1 PF01926.18 KOH00982.1 - 0.0026 17.6 0.3 0.17 11.8 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 KOH00982.1 - 0.0072 15.5 0.1 3.1 6.9 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 T2SE PF00437.15 KOH00982.1 - 0.015 14.1 0.2 0.72 8.7 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein ResIII PF04851.10 KOH00982.1 - 0.016 15.0 0.0 8.4 6.1 0.0 2.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Arch_ATPase PF01637.13 KOH00982.1 - 0.021 14.5 0.1 0.12 12.0 0.0 2.3 2 0 0 2 2 2 0 Archaeal ATPase Cytomega_TRL10 PF06084.6 KOH00982.1 - 0.068 12.9 0.8 0.31 10.8 0.1 2.4 3 0 0 3 3 2 0 Cytomegalovirus TRL10 protein AAA_17 PF13207.1 KOH00982.1 - 0.071 13.9 0.1 3.2 8.6 0.0 3.1 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.1 KOH00982.1 - 0.081 12.8 10.7 5.2 6.9 0.2 4.8 4 1 0 4 4 3 0 AAA domain cobW PF02492.14 KOH00982.1 - 0.12 11.8 2.2 0.33 10.3 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.7 KOH00982.1 - 0.13 11.3 1.1 12 4.8 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin MobB PF03205.9 KOH00982.1 - 0.35 10.5 1.8 18 4.9 0.1 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 KOH00982.1 - 0.47 9.9 1.3 45 3.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.1 KOH00982.1 - 0.58 10.3 3.3 11 6.2 0.1 3.3 2 1 0 2 2 2 0 AAA domain AAA_10 PF12846.2 KOH00982.1 - 1.6 8.0 5.1 23 4.3 0.1 3.0 3 0 0 3 3 3 0 AAA-like domain Rgp1 PF08737.5 KOH00983.1 - 5.3e-107 358.4 8.0 5.3e-107 358.4 5.6 1.8 2 0 0 2 2 2 1 Rgp1 efThoc1 PF11957.3 KOH00984.1 - 7.6e-103 344.6 28.1 1e-102 344.2 19.5 1.1 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor ubiquitin PF00240.18 KOH00985.1 - 3.1e-17 61.7 0.2 4.4e-17 61.2 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 KOH00985.1 - 6.3e-10 38.6 0.1 8e-10 38.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 KOH00985.1 - 0.055 13.7 0.0 0.057 13.6 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-like domain Methyltransf_26 PF13659.1 KOH00986.1 - 3.3e-16 59.3 0.0 4.9e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOH00986.1 - 2.1e-11 43.4 0.0 2.7e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 KOH00986.1 - 3.1e-07 30.0 0.0 4.5e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOH00986.1 - 0.00081 18.5 0.1 0.0015 17.7 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.1 KOH00986.1 - 0.0054 17.0 0.0 0.012 15.9 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOH00986.1 - 0.02 15.3 0.0 0.061 13.8 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.4 KOH00986.1 - 0.026 13.9 0.0 2 7.8 0.0 2.2 2 0 0 2 2 2 0 Putative methyltransferase DUF3749 PF12568.3 KOH00986.1 - 0.036 13.6 0.0 0.095 12.2 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Methyltransf_18 PF12847.2 KOH00986.1 - 0.044 14.3 0.0 0.083 13.4 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.11 KOH00986.1 - 0.051 13.1 0.0 0.072 12.6 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein N6-adenineMlase PF10237.4 KOH00986.1 - 0.051 13.2 0.1 0.29 10.7 0.1 2.1 1 1 0 1 1 1 0 Probable N6-adenine methyltransferase DUF1269 PF06897.7 KOH00986.1 - 0.087 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) Dopey_N PF04118.9 KOH00987.1 - 3.6e-119 397.1 0.3 3.6e-119 397.1 0.2 3.0 3 1 0 3 3 3 1 Dopey, N-terminal WD40 PF00400.27 KOH00988.1 - 1.9e-28 97.2 12.9 6.4e-07 29.0 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat zf-RING_2 PF13639.1 KOH00989.1 - 7.7e-12 44.8 4.7 4.8e-10 39.1 0.9 2.3 2 0 0 2 2 2 2 Ring finger domain zf-rbx1 PF12678.2 KOH00989.1 - 4e-07 30.0 1.5 8.3e-06 25.8 0.3 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 KOH00989.1 - 4.3e-06 26.6 5.6 8.8e-06 25.6 0.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOH00989.1 - 8.7e-06 25.3 4.0 1.1e-05 25.0 0.1 2.9 2 1 1 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.1 KOH00989.1 - 3.5e-05 23.4 4.1 0.00034 20.2 0.4 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOH00989.1 - 0.00011 21.8 3.2 0.0002 20.9 0.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KOH00989.1 - 0.00063 19.5 1.0 0.00063 19.5 0.7 1.9 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING Rtf2 PF04641.7 KOH00989.1 - 0.00075 18.7 0.0 0.00075 18.7 0.0 3.6 2 2 1 3 3 2 1 Rtf2 RING-finger zf-C3HC4 PF00097.20 KOH00989.1 - 0.0016 18.0 5.7 0.005 16.4 0.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.1 KOH00989.1 - 0.011 15.2 2.3 0.011 15.2 0.6 1.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-Apc11 PF12861.2 KOH00989.1 - 0.023 14.5 0.3 0.055 13.3 0.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.3 KOH00989.1 - 0.95 9.4 4.7 38 4.3 1.2 3.3 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_4 PF14570.1 KOH00989.1 - 1.3 8.6 4.1 1.3 8.6 0.6 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Asp PF00026.18 KOH00990.1 - 8e-69 232.2 20.8 8e-69 232.2 14.4 2.2 2 1 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOH00990.1 - 6.2e-11 42.5 0.0 1.8e-08 34.4 0.0 3.7 3 2 0 3 3 3 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 KOH00990.1 - 0.0031 17.0 0.8 0.74 9.3 0.0 2.7 3 0 0 3 3 3 2 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 KOH00990.1 - 0.033 14.6 1.7 37 4.8 0.0 3.8 3 0 0 3 3 3 0 Aspartyl protease TFIID_20kDa PF03847.8 KOH00991.1 - 3.2e-33 113.8 6.3 3.7e-33 113.6 0.3 2.5 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A Histone PF00125.19 KOH00991.1 - 0.00062 19.8 0.1 0.01 15.9 0.0 2.5 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 zf-C2H2 PF00096.21 KOH00992.1 - 3.9e-10 39.4 11.4 0.002 18.3 0.7 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KOH00992.1 - 1e-06 28.7 10.9 0.0024 18.0 0.0 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOH00992.1 - 2.3e-05 24.4 9.3 0.032 14.5 0.5 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger Tektin PF03148.9 KOH00992.1 - 0.016 13.7 5.1 0.025 13.1 3.5 1.2 1 0 0 1 1 1 0 Tektin family zf-C2H2_jaz PF12171.3 KOH00992.1 - 0.016 15.3 8.1 6.2 7.0 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 KOH00992.1 - 0.028 14.3 2.0 1.7 8.6 0.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Bunya_G2 PF03563.8 KOH00992.1 - 0.03 13.2 0.3 0.05 12.4 0.2 1.2 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 WEMBL PF05701.6 KOH00992.1 - 0.034 12.6 6.0 0.049 12.0 4.2 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light AT_hook PF02178.14 KOH00992.1 - 0.15 11.7 5.7 0.54 10.1 3.9 2.0 1 0 0 1 1 1 0 AT hook motif zf-TRAF PF02176.13 KOH00992.1 - 0.33 11.3 3.2 0.22 11.9 0.5 2.0 1 1 1 2 2 2 0 TRAF-type zinc finger Choline_kinase PF01633.15 KOH00993.1 - 5.8e-59 199.1 1.5 8.3e-59 198.6 1.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.9 KOH00993.1 - 6.2e-12 44.7 0.1 1.5e-11 43.5 0.0 1.7 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.18 KOH00993.1 - 1.1e-09 38.3 0.1 2.5e-09 37.2 0.1 1.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.15 KOH00993.1 - 5.5e-06 25.7 1.7 8.3e-06 25.1 1.2 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.6 KOH00993.1 - 0.0005 18.8 0.4 0.00082 18.1 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) 2-oxoacid_dh PF00198.18 KOH00994.1 - 2e-81 272.6 0.1 2.7e-81 272.2 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 KOH00994.1 - 3.1e-16 58.7 0.5 5.7e-16 57.9 0.4 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme GCV_H PF01597.14 KOH00994.1 - 0.00029 20.5 0.5 0.0014 18.2 0.1 2.2 1 1 1 2 2 2 1 Glycine cleavage H-protein Biotin_lipoyl_2 PF13533.1 KOH00994.1 - 0.0013 18.2 0.2 0.042 13.5 0.0 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.1 KOH00994.1 - 0.0037 17.5 0.1 0.014 15.7 0.0 2.0 1 1 1 2 2 2 1 HlyD family secretion protein RnfC_N PF13375.1 KOH00994.1 - 0.0057 16.3 0.0 0.024 14.3 0.0 2.0 1 1 1 2 2 2 1 RnfC Barrel sandwich hybrid domain HlyD PF00529.15 KOH00994.1 - 0.011 15.0 0.8 0.12 11.6 0.4 2.2 1 1 1 2 2 2 0 HlyD family secretion protein DUF2118 PF09891.4 KOH00994.1 - 0.035 13.8 0.0 0.078 12.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) MSA-2c PF12238.3 KOH00994.1 - 0.27 10.8 13.5 0.71 9.5 7.7 2.3 2 0 0 2 2 2 0 Merozoite surface antigen 2c zf-CCCH PF00642.19 KOH00995.1 - 2.7e-18 65.1 16.0 3.5e-09 36.1 4.3 2.2 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 KOH00995.1 - 2.8 8.0 14.2 2.3 8.3 1.0 2.7 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type RWD PF05773.17 KOH00996.1 - 8.5e-22 77.1 12.1 3e-21 75.4 8.4 1.9 1 1 0 1 1 1 1 RWD domain Sporozoite_P67 PF05642.6 KOH00996.1 - 0.47 8.2 3.7 0.64 7.8 2.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NOA36 PF06524.7 KOH00996.1 - 1.4 8.1 6.4 3.1 6.9 4.4 1.5 1 0 0 1 1 1 0 NOA36 protein DUF778 PF05608.7 KOH00996.1 - 1.7 8.5 4.9 0.72 9.7 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF778) EBV-NA3 PF05009.7 KOH00996.1 - 2.5 7.2 6.8 3.8 6.6 2.8 2.1 2 0 0 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) DUF2457 PF10446.4 KOH00996.1 - 3.4 6.3 13.2 6.8 5.2 9.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nucleoplasmin PF03066.10 KOH00996.1 - 4.6 6.7 15.5 0.15 11.5 5.6 2.1 2 0 0 2 2 2 0 Nucleoplasmin RNase_H2_suC PF08615.6 KOH00996.1 - 9.7 6.0 7.4 20 5.0 5.1 1.6 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) BSP_II PF05432.6 KOH00996.1 - 10 5.3 18.3 0.59 9.3 8.1 2.0 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) ENTH PF01417.15 KOH00997.1 - 6.1e-30 103.6 0.1 1.1e-29 102.8 0.0 1.4 1 0 0 1 1 1 1 ENTH domain Cas_Csy4 PF09618.5 KOH00997.1 - 0.51 10.1 3.9 0.45 10.3 1.5 1.7 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) DUF3685 PF12452.3 KOH00997.1 - 1.5 7.9 4.3 2.5 7.2 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3685) Tankyrase_bdg_C PF15327.1 KOH00997.1 - 4 7.6 9.2 1.3 9.1 4.4 1.6 2 0 0 2 2 2 0 Tankyrase binding protein C terminal domain DUF789 PF05623.7 KOH00997.1 - 9.1 5.6 13.0 1 8.8 0.2 3.3 1 1 3 4 4 4 0 Protein of unknown function (DUF789) Pro_isomerase PF00160.16 KOH00998.1 - 1e-45 155.6 0.1 1.2e-45 155.5 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RNA_polI_A14 PF08203.6 KOH00999.1 - 8.1e-26 90.0 0.2 1e-24 86.5 0.0 2.2 2 0 0 2 2 2 1 Yeast RNA polymerase I subunit RPA14 Semialdhyde_dhC PF02774.13 KOH01000.1 - 2.7e-44 151.2 0.0 3.9e-44 150.7 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.19 KOH01000.1 - 9.2e-32 109.9 0.0 1.5e-31 109.1 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.11 KOH01000.1 - 0.016 15.7 0.0 0.042 14.3 0.0 1.7 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase DapB_N PF01113.15 KOH01000.1 - 0.06 13.2 0.0 0.13 12.2 0.0 1.6 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Saccharop_dh PF03435.13 KOH01000.1 - 0.093 11.6 0.1 0.18 10.7 0.0 1.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase SAC3_GANP PF03399.11 KOH01001.1 - 1.3e-56 191.3 0.5 1.3e-56 191.3 0.4 2.4 3 0 0 3 3 3 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family SAC3 PF12209.3 KOH01001.1 - 1.1e-21 76.7 3.4 1.1e-21 76.7 2.3 3.0 3 0 0 3 3 3 1 Leucine permease transcriptional regulator helical domain AA_permease PF00324.16 KOH01002.1 - 2.1e-71 240.7 38.6 3.3e-71 240.0 26.7 1.3 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOH01002.1 - 3.4e-29 101.6 41.5 1.7e-28 99.3 28.7 1.9 1 1 0 1 1 1 1 Amino acid permease TPR_19 PF14559.1 KOH01003.1 - 8.3e-07 29.2 5.4 0.00019 21.6 0.5 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOH01003.1 - 8.3e-07 28.5 3.8 0.011 15.3 0.0 3.6 3 1 0 3 3 3 1 TPR repeat Apc3 PF12895.2 KOH01003.1 - 1.5e-05 24.9 1.5 0.052 13.6 0.3 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 KOH01003.1 - 3.9e-05 23.9 0.5 0.25 12.0 0.0 4.2 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOH01003.1 - 0.00013 22.5 2.2 4.6 8.0 0.1 4.3 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOH01003.1 - 0.00023 20.8 7.7 0.66 10.0 0.0 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOH01003.1 - 0.00041 20.2 2.0 1.7 8.6 0.0 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOH01003.1 - 0.0065 16.5 0.1 3.4 8.0 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOH01003.1 - 0.023 14.4 0.8 45 4.1 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.4 KOH01003.1 - 0.028 14.3 2.3 3.6 7.5 1.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOH01003.1 - 0.032 14.0 2.9 0.96 9.3 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.1 KOH01003.1 - 0.037 13.0 0.7 3.8 6.4 0.2 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat YfdX PF10938.3 KOH01003.1 - 0.04 13.5 3.1 0.28 10.8 2.1 2.3 1 1 0 1 1 1 0 YfdX protein TPR_9 PF13371.1 KOH01003.1 - 0.075 12.8 0.0 20 5.1 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOH01003.1 - 0.19 11.3 10.2 0.46 10.1 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat SH3_9 PF14604.1 KOH01004.1 - 1.1e-12 47.2 0.0 2.4e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 KOH01004.1 - 2.4e-12 46.0 0.0 2.4e-12 46.0 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.12 KOH01004.1 - 2.1e-05 23.9 0.0 5.1e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain Cwf_Cwc_15 PF04889.7 KOH01005.1 - 2.5e-16 60.1 35.5 9.8e-09 35.2 0.9 3.1 1 1 2 3 3 3 3 Cwf15/Cwc15 cell cycle control protein BNIP2 PF12496.3 KOH01005.1 - 0.0092 16.1 4.3 0.012 15.7 2.9 1.2 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 DNA_pol_phi PF04931.8 KOH01005.1 - 1.8 6.2 16.8 2.3 5.8 11.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.9 KOH01005.1 - 5.4 4.9 13.5 7 4.5 9.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Sec1 PF00995.18 KOH01006.1 - 4.4e-95 319.4 2.0 5.2e-95 319.2 1.4 1.0 1 0 0 1 1 1 1 Sec1 family WD40 PF00400.27 KOH01007.1 - 5e-08 32.5 2.9 0.00039 20.2 0.4 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat CPSF_A PF03178.10 KOH01007.1 - 5.2e-06 25.7 2.0 0.0001 21.5 0.0 2.9 2 1 1 3 3 3 1 CPSF A subunit region CTDII PF01556.13 KOH01007.1 - 0.027 14.3 0.5 0.075 12.9 0.1 1.8 2 0 0 2 2 2 0 DnaJ C terminal domain Sec5 PF15469.1 KOH01008.1 - 5.3e-42 143.5 14.6 5.3e-42 143.5 10.1 2.5 3 0 0 3 3 3 1 Exocyst complex component Sec5 Vps51 PF08700.6 KOH01008.1 - 4.9e-05 23.0 2.9 4.9e-05 23.0 2.0 2.9 2 1 0 2 2 2 1 Vps51/Vps67 DUF2982 PF11201.3 KOH01008.1 - 0.0071 15.7 1.1 0.015 14.6 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2982) MtrG PF04210.8 KOH01008.1 - 0.023 14.3 0.6 0.18 11.4 0.0 2.7 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G HJURP_C PF12347.3 KOH01008.1 - 0.1 12.1 0.2 1.1 8.9 0.2 2.4 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat TFIID_30kDa PF03540.8 KOH01009.1 - 5.5e-27 93.3 0.2 8.2e-27 92.7 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.8 KOH01009.1 - 0.043 13.5 0.3 0.65 9.7 0.0 2.7 3 0 0 3 3 3 0 Bromodomain associated CDC37_N PF03234.9 KOH01010.1 - 8.2e-64 215.1 16.4 8.2e-64 215.1 11.4 3.6 2 1 1 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.6 KOH01010.1 - 1.7e-50 170.9 10.7 5.7e-50 169.1 7.4 2.0 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.5 KOH01010.1 - 4.1e-23 81.1 4.9 4.1e-23 81.1 3.4 2.6 4 0 0 4 4 4 1 Cdc37 C terminal domain PMC2NT PF08066.7 KOH01010.1 - 2 8.7 8.8 5.4 7.3 0.6 3.6 3 1 0 3 3 3 0 PMC2NT (NUC016) domain Stb3 PF10330.4 KOH01011.1 - 6.7e-33 112.2 0.0 1.4e-32 111.2 0.0 1.5 1 0 0 1 1 1 1 Putative Sin3 binding protein Sec7 PF01369.15 KOH01013.1 - 1.9e-65 220.1 0.1 7.4e-65 218.1 0.0 2.1 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 KOH01013.1 - 5.4e-52 175.6 1.2 5.4e-52 175.6 0.8 3.1 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.5 KOH01013.1 - 5e-26 90.0 0.4 5e-26 90.0 0.3 4.2 5 0 0 5 5 5 1 Domain of unknown function (DUF1981) HSP20 PF00011.16 KOH01014.1 - 1.1e-11 44.4 0.1 2.8e-11 43.1 0.1 1.7 1 0 0 1 1 1 1 Hsp20/alpha crystallin family GTP_EFTU PF00009.22 KOH01015.1 - 1.4e-46 158.2 1.5 3.7e-46 156.9 0.0 2.2 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 KOH01015.1 - 1.2e-25 89.5 4.3 2.2e-25 88.6 0.8 2.5 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 KOH01015.1 - 1.2e-07 31.7 0.4 3.6e-07 30.2 0.3 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KOH01015.1 - 9.6e-05 22.3 0.7 0.00094 19.1 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase IPK PF03770.11 KOH01016.1 - 3.9e-55 186.5 0.3 4.8e-55 186.2 0.2 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase ASFV_360 PF01671.11 KOH01016.1 - 0.01 15.2 0.1 0.016 14.5 0.1 1.2 1 0 0 1 1 1 0 African swine fever virus multigene family 360 protein HMG_box PF00505.14 KOH01017.1 - 7.1e-12 45.4 4.1 7.1e-12 45.4 2.9 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOH01017.1 - 2.8e-09 37.1 2.7 2.8e-09 37.1 1.9 1.7 2 0 0 2 2 2 1 HMG-box domain MRP-S28 PF10213.4 KOH01018.1 - 6.2e-50 168.5 5.6 1.2e-49 167.6 3.9 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein PRANC PF09372.5 KOH01018.1 - 0.059 13.3 0.3 0.13 12.2 0.2 1.5 1 0 0 1 1 1 0 PRANC domain Ada3 PF10198.4 KOH01019.1 - 2.7e-47 159.7 4.1 2.7e-47 159.7 2.9 2.3 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 UQ_con PF00179.21 KOH01020.1 - 7.7e-44 148.5 0.0 1e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.5 KOH01020.1 - 1.9e-30 104.2 1.3 2.9e-30 103.6 0.9 1.3 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.1 KOH01020.1 - 0.00045 19.9 0.0 0.00071 19.3 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B UBA_2 PF08587.6 KOH01020.1 - 0.032 14.3 0.1 0.064 13.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) RWD PF05773.17 KOH01020.1 - 0.036 13.9 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 RWD domain CybS PF05328.7 KOH01021.1 - 6.8e-48 161.6 0.0 8.4e-48 161.3 0.0 1.1 1 0 0 1 1 1 1 CybS PCI PF01399.22 KOH01022.1 - 0.0047 17.2 0.6 0.0076 16.5 0.4 1.4 1 0 0 1 1 1 1 PCI domain BAH PF01426.13 KOH01022.1 - 0.011 15.4 0.3 0.017 14.9 0.2 1.4 1 0 0 1 1 1 0 BAH domain PXA PF02194.10 KOH01023.1 - 2.2e-08 33.9 0.2 1e-07 31.7 0.0 2.1 2 1 0 2 2 2 1 PXA domain Nipped-B_C PF12830.2 KOH01024.1 - 8.1e-38 129.9 6.4 7.1e-36 123.6 0.8 4.0 3 0 0 3 3 3 2 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.2 KOH01024.1 - 1.7e-14 53.4 2.7 2.5e-13 49.6 1.0 2.8 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.17 KOH01024.1 - 0.0038 17.1 4.3 34 4.8 0.1 6.0 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.1 KOH01024.1 - 0.063 13.5 0.1 0.78 10.0 0.0 2.9 2 0 0 2 2 2 0 HEAT repeats SAS4 PF15460.1 KOH01025.1 - 1.1e-30 105.4 5.0 1.1e-30 105.4 3.5 2.5 3 0 0 3 3 3 1 Something about silencing, SAS, complex subunit 4 Metallophos PF00149.23 KOH01026.1 - 3.8e-16 59.0 0.3 6.2e-16 58.3 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF912 PF06024.7 KOH01026.1 - 0.088 12.8 0.1 2.3 8.3 0.0 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) 7tm_1 PF00001.16 KOH01026.1 - 0.093 11.8 2.4 3 6.9 0.1 2.2 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) Phosducin PF02114.11 KOH01027.1 - 2.5e-08 33.0 0.5 2.9e-08 32.7 0.3 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.15 KOH01027.1 - 8.9e-06 25.3 0.2 2e-05 24.2 0.0 1.6 2 0 0 2 2 2 1 Thioredoxin Synaphin PF05835.7 KOH01027.1 - 0.072 13.2 2.7 0.099 12.7 1.9 1.2 1 0 0 1 1 1 0 Synaphin protein FANCL_C PF11793.3 KOH01027.1 - 0.077 12.9 0.1 1.2 9.1 0.0 2.3 1 1 1 2 2 2 0 FANCL C-terminal domain Sigma70_ner PF04546.8 KOH01027.1 - 0.1 12.2 2.9 0.15 11.6 2.0 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region PRELI PF04707.9 KOH01029.1 - 2.1e-56 189.8 0.4 2.5e-56 189.5 0.3 1.0 1 0 0 1 1 1 1 PRELI-like family Cpn60_TCP1 PF00118.19 KOH01031.1 - 5.4e-145 483.7 0.8 6.2e-145 483.5 0.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sec1 PF00995.18 KOH01032.1 - 1.2e-146 489.6 4.3 1.2e-146 489.6 3.0 1.3 2 0 0 2 2 2 1 Sec1 family TIP49 PF06068.8 KOH01033.1 - 1.1e-188 626.9 0.5 1.3e-188 626.6 0.4 1.0 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.7 KOH01033.1 - 7.3e-09 35.0 1.9 0.00013 21.0 0.0 3.1 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.24 KOH01033.1 - 2.2e-08 34.3 0.4 8.5e-05 22.7 0.0 2.7 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 KOH01033.1 - 0.0012 18.8 0.0 0.0023 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOH01033.1 - 0.002 18.1 0.0 0.24 11.3 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 KOH01033.1 - 0.0047 16.6 0.1 0.021 14.5 0.1 2.1 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 KOH01033.1 - 0.011 14.8 0.1 0.027 13.5 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 KOH01033.1 - 0.014 15.3 0.0 1.2 9.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 KOH01033.1 - 0.021 14.5 0.2 0.69 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 KOH01033.1 - 0.023 13.8 0.1 4 6.5 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DnaB_C PF03796.10 KOH01033.1 - 0.025 13.4 0.0 0.045 12.6 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain CPT PF07931.7 KOH01033.1 - 0.044 13.3 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein ORC3_N PF07034.6 KOH01033.1 - 0.13 11.2 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus SIR2 PF02146.12 KOH01034.1 - 2.6e-24 85.9 0.0 4.9e-24 85.0 0.0 1.5 1 1 0 1 1 1 1 Sir2 family DEAD PF00270.24 KOH01035.1 - 3.7e-42 143.6 0.2 1.5e-39 135.2 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 KOH01035.1 - 4.4e-22 77.7 0.0 9.5e-22 76.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOH01035.1 - 1.5e-05 24.8 3.9 3.7e-05 23.6 0.1 2.7 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 KOH01035.1 - 0.0033 17.3 0.0 0.0089 15.9 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain MazG PF03819.12 KOH01035.1 - 0.02 14.8 0.3 0.067 13.1 0.2 1.9 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain AAA_30 PF13604.1 KOH01035.1 - 0.089 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain CoaE PF01121.15 KOH01037.1 - 6.4e-67 224.4 0.0 7.9e-67 224.1 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_17 PF13207.1 KOH01037.1 - 1.4e-07 32.3 0.1 2.5e-07 31.5 0.1 1.7 1 1 0 1 1 1 1 AAA domain SKI PF01202.17 KOH01037.1 - 0.0011 18.8 0.7 0.023 14.5 0.0 2.3 2 1 0 2 2 2 1 Shikimate kinase Cytidylate_kin2 PF13189.1 KOH01037.1 - 0.0016 18.3 0.0 0.02 14.7 0.0 2.1 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_33 PF13671.1 KOH01037.1 - 0.0024 17.7 0.0 0.012 15.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KOH01037.1 - 0.0033 17.7 0.2 0.014 15.7 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOH01037.1 - 0.0046 16.9 0.0 0.015 15.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain PRK PF00485.13 KOH01037.1 - 0.017 14.6 0.1 0.083 12.4 0.0 2.0 2 1 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.1 KOH01037.1 - 0.021 14.8 0.0 0.037 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain tRNA_lig_kinase PF08303.6 KOH01037.1 - 0.089 12.6 0.0 0.23 11.3 0.0 1.7 2 0 0 2 2 2 0 tRNA ligase kinase domain ApbA_C PF08546.6 KOH01038.1 - 1.1e-16 60.9 0.0 1.9e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal SET PF00856.23 KOH01039.1 - 0.006 16.9 1.4 0.03 14.6 0.9 2.5 1 1 0 1 1 1 1 SET domain MAT_Alpha1 PF04769.7 KOH01039.1 - 0.0077 15.5 0.9 0.14 11.5 0.4 2.2 2 0 0 2 2 2 1 Mating-type protein MAT alpha 1 FHA PF00498.21 KOH01040.1 - 6.2e-18 64.6 0.2 3.7e-17 62.1 0.1 2.5 1 1 1 2 2 2 1 FHA domain DASH_Spc19 PF08287.6 KOH01041.1 - 3.9e-45 153.1 10.0 4.4e-45 153.0 6.9 1.0 1 0 0 1 1 1 1 Spc19 Vfa1 PF08432.5 KOH01041.1 - 0.095 12.7 2.3 0.14 12.2 0.8 1.8 1 1 1 2 2 2 0 AAA-ATPase Vps4-associated protein 1 EzrA PF06160.7 KOH01041.1 - 0.16 10.1 7.8 0.052 11.7 3.3 1.7 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA Mnd1 PF03962.10 KOH01041.1 - 0.36 10.4 6.1 1.2 8.7 4.2 1.9 1 1 0 1 1 1 0 Mnd1 family Bap31 PF05529.7 KOH01041.1 - 0.51 9.7 7.6 2.1 7.7 1.5 2.1 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like DUF342 PF03961.8 KOH01041.1 - 0.51 8.6 6.5 0.57 8.5 3.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF342) YPEB PF14620.1 KOH01041.1 - 0.64 8.9 6.7 1.6 7.6 1.6 2.2 2 0 0 2 2 2 0 YpeB sporulation DASH_Dad2 PF08654.5 KOH01041.1 - 1.5 8.8 12.8 6.9 6.7 3.1 3.2 3 0 0 3 3 3 0 DASH complex subunit Dad2 Spc24 PF08286.6 KOH01041.1 - 3.7 7.2 14.8 16 5.2 0.1 3.1 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 Baculo_PEP_C PF04513.7 KOH01041.1 - 5.1 6.9 7.7 12 5.6 0.0 3.0 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rootletin PF15035.1 KOH01041.1 - 5.1 7.0 14.2 0.55 10.1 2.3 2.1 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Fib_alpha PF08702.5 KOH01041.1 - 6.3 6.9 9.4 11 6.1 4.1 2.2 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF2205 PF10224.4 KOH01041.1 - 7.3 6.2 13.3 5.4 6.6 0.1 3.3 3 1 0 3 3 3 0 Predicted coiled-coil protein (DUF2205) FlaC_arch PF05377.6 KOH01041.1 - 9.3 6.2 9.6 9.4 6.2 0.1 3.6 3 2 0 3 3 3 0 Flagella accessory protein C (FlaC) Rogdi_lz PF10259.4 KOH01042.1 - 2.7e-84 282.5 4.9 3.1e-84 282.3 3.4 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Coq4 PF05019.8 KOH01043.1 - 1.1e-98 328.5 0.0 1.4e-98 328.2 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 GreA_GreB_N PF03449.10 KOH01043.1 - 1.1 9.3 4.8 0.37 10.8 1.0 1.9 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal Cation_efflux PF01545.16 KOH01044.1 - 8.1e-56 189.1 7.4 8.1e-56 189.1 5.1 3.0 3 1 0 3 3 3 2 Cation efflux family DUF2946 PF11162.3 KOH01044.1 - 0.64 10.2 6.3 15 5.7 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2946) EST1_DNA_bind PF10373.4 KOH01045.1 - 2.4e-48 164.7 0.6 5.2e-48 163.6 0.0 1.9 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.4 KOH01045.1 - 8.6e-25 87.2 6.2 1.5e-24 86.4 2.0 2.7 2 0 0 2 2 2 1 Telomerase activating protein Est1 Zn_clus PF00172.13 KOH01046.1 - 8e-09 35.2 8.7 1.4e-08 34.4 6.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PIP5K PF01504.13 KOH01047.1 - 2.2e-84 282.5 3.2 4.6e-84 281.4 2.2 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase W2 PF02020.13 KOH01048.1 - 1.2e-15 57.2 2.0 3.6e-15 55.6 1.4 1.9 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.19 KOH01048.1 - 3.6e-11 42.0 16.2 0.0017 17.7 1.3 4.3 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.18 KOH01048.1 - 5.3e-09 35.7 0.0 1.1e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.1 KOH01048.1 - 0.0037 16.7 16.9 0.096 12.2 0.3 4.3 2 2 2 4 4 4 2 Hexapeptide repeat of succinyl-transferase NTP_transf_3 PF12804.2 KOH01048.1 - 0.0098 15.9 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Cpn60_TCP1 PF00118.19 KOH01049.1 - 3.6e-142 474.3 11.8 4.2e-142 474.1 8.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Fungal_trans_2 PF11951.3 KOH01050.1 - 2.8e-11 42.6 0.2 2.8e-11 42.6 0.1 3.0 2 1 1 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.13 KOH01050.1 - 3.9e-08 33.0 10.5 6.1e-08 32.4 7.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aha1_N PF09229.6 KOH01051.1 - 1.3e-38 131.9 0.7 5.8e-38 129.8 0.1 2.2 2 1 0 3 3 3 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.6 KOH01051.1 - 2.6e-11 43.7 0.2 3.9e-11 43.1 0.2 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein zf-C2H2 PF00096.21 KOH01052.1 - 2.9e-10 39.8 10.3 4.1e-05 23.6 1.6 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOH01052.1 - 3.8e-07 29.9 11.9 0.0015 18.7 2.1 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KOH01052.1 - 1.8e-05 24.8 7.1 1.8e-05 24.8 4.9 2.9 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.2 KOH01052.1 - 0.00054 20.0 7.9 0.0068 16.5 0.6 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KOH01052.1 - 0.45 10.7 4.6 0.29 11.3 0.8 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Septin PF00735.13 KOH01053.1 - 1.5e-66 224.3 1.6 3.4e-66 223.1 1.1 1.5 1 1 0 1 1 1 1 Septin BofC_C PF08955.5 KOH01053.1 - 0.067 13.2 0.1 0.39 10.7 0.0 2.2 2 0 0 2 2 2 0 BofC C-terminal domain Dynamin_N PF00350.18 KOH01053.1 - 0.12 12.2 2.2 0.23 11.2 0.0 2.4 3 0 0 3 3 3 0 Dynamin family AAA_18 PF13238.1 KOH01053.1 - 0.21 11.8 4.6 0.21 11.8 0.0 3.1 3 1 0 3 3 3 0 AAA domain F-box PF00646.28 KOH01054.1 - 8.2e-06 25.3 0.1 2.2e-05 23.9 0.1 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 KOH01054.1 - 2.7e-05 23.7 0.0 8.4e-05 22.2 0.0 1.8 1 0 0 1 1 1 1 F-box-like PRKCSH-like PF12999.2 KOH01055.1 - 3.8e-30 104.7 11.2 2.2e-29 102.2 7.7 2.3 1 1 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.1 KOH01055.1 - 1.1e-20 73.6 2.0 4.1e-19 68.5 1.4 2.9 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.8 KOH01055.1 - 7.6e-08 33.0 0.5 2.7e-07 31.3 0.4 2.0 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Ldl_recept_a PF00057.13 KOH01055.1 - 0.018 14.9 12.8 0.2 11.6 1.3 2.6 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A Ax_dynein_light PF10211.4 KOH01055.1 - 1.5 8.5 7.3 0.73 9.6 0.1 3.0 3 1 1 4 4 4 0 Axonemal dynein light chain Svf1 PF08622.5 KOH01056.1 - 1.1e-99 333.5 0.6 1.4e-99 333.2 0.4 1.1 1 0 0 1 1 1 1 Svf1-like Lactococcin PF04369.8 KOH01056.1 - 0.54 10.2 3.4 2.6 8.0 0.1 2.5 2 0 0 2 2 2 0 Lactococcin-like family CRF1 PF10380.4 KOH01057.1 - 9.8e-23 80.8 1.3 9.8e-23 80.8 0.9 2.7 3 1 0 3 3 3 1 Transcription factor CRF1 Pectate_lyase_3 PF12708.2 KOH01057.1 - 0.026 14.6 0.2 0.077 13.0 0.0 1.8 2 0 0 2 2 2 0 Pectate lyase superfamily protein Histone PF00125.19 KOH01058.1 - 1.4e-21 76.3 0.3 2e-21 75.8 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KOH01058.1 - 6.6e-06 26.0 0.1 1.4e-05 25.0 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 KOH01058.1 - 0.0013 18.9 0.0 0.0022 18.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Mitofilin PF09731.4 KOH01058.1 - 0.038 12.6 3.0 0.046 12.3 2.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF1018 PF06252.7 KOH01058.1 - 0.095 13.2 0.6 0.13 12.7 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) Histone PF00125.19 KOH01059.1 - 6.5e-26 90.2 0.0 8.8e-26 89.8 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KOH01059.1 - 9.8e-06 25.5 0.0 1.5e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone ADK PF00406.17 KOH01060.1 - 6.8e-60 201.3 0.0 8.1e-60 201.0 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 KOH01060.1 - 4.4e-14 51.8 0.0 9.7e-14 50.7 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.1 KOH01060.1 - 5.1e-08 32.9 0.0 1.1e-07 31.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOH01060.1 - 1.5e-05 25.8 0.0 3.3e-05 24.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOH01060.1 - 0.00037 20.8 0.0 0.00071 19.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOH01060.1 - 0.0027 16.8 0.0 0.0053 15.8 0.0 1.6 2 0 0 2 2 2 1 Zeta toxin AAA_28 PF13521.1 KOH01060.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain CFIA_Pcf11 PF11526.3 KOH01062.1 - 1.9e-25 88.7 14.5 1.9e-25 88.7 10.0 2.8 2 1 0 2 2 2 1 Subunit of cleavage factor IA Pcf11 VHS PF00790.14 KOH01062.1 - 0.0084 15.7 3.0 0.017 14.7 0.0 2.8 3 0 0 3 3 3 1 VHS domain zf-H2C2_2 PF13465.1 KOH01062.1 - 0.022 15.0 0.4 5.3 7.5 0.0 2.9 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOH01062.1 - 0.094 13.0 0.9 3.7 8.1 0.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger TF_Zn_Ribbon PF08271.7 KOH01062.1 - 0.78 9.1 4.2 0.38 10.1 0.1 2.5 3 0 0 3 3 3 0 TFIIB zinc-binding zf-C2H2_6 PF13912.1 KOH01062.1 - 1.1 9.2 4.2 3.3 7.7 0.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger MalF_P2 PF14785.1 KOH01063.1 - 0.027 14.3 0.7 0.065 13.0 0.5 1.6 1 0 0 1 1 1 0 Maltose transport system permease protein MalF P2 domain Herpes_UL36 PF03586.8 KOH01063.1 - 0.034 13.2 0.1 0.12 11.5 0.1 1.8 2 0 0 2 2 2 0 Herpesvirus UL36 tegument protein Peptidase_C97 PF05903.9 KOH01063.1 - 0.05 13.3 0.2 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 PPPDE putative peptidase domain BMFP PF04380.8 KOH01063.1 - 0.061 13.4 1.4 0.11 12.6 0.5 1.9 2 0 0 2 2 2 0 Membrane fusogenic activity DUF3767 PF12597.3 KOH01064.1 - 1.3e-41 140.9 0.1 1.3e-41 140.9 0.1 1.9 3 0 0 3 3 3 1 Protein of unknown function (DUF3767) DUF4131 PF13567.1 KOH01064.1 - 0.062 12.7 0.1 0.11 11.9 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Aminotran_1_2 PF00155.16 KOH01065.1 - 1.9e-72 244.2 0.2 7.7e-72 242.2 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 KOH01065.1 - 1.7e-08 33.1 0.0 3.4e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 KOH01065.1 - 6.1e-06 25.2 0.0 1.3e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V DHHA1 PF02272.14 KOH01065.1 - 0.015 14.9 0.0 0.052 13.2 0.0 2.0 1 0 0 1 1 1 0 DHHA1 domain DegT_DnrJ_EryC1 PF01041.12 KOH01065.1 - 0.26 10.3 0.0 0.26 10.3 0.0 2.6 3 0 0 3 3 3 0 DegT/DnrJ/EryC1/StrS aminotransferase family Reticulon PF02453.12 KOH01066.1 - 5.7e-38 130.1 2.1 8.5e-38 129.6 1.4 1.2 1 0 0 1 1 1 1 Reticulon DRTGG PF07085.7 KOH01067.1 - 0.15 11.7 0.0 0.85 9.2 0.0 2.1 2 0 0 2 2 2 0 DRTGG domain Aconitase PF00330.15 KOH01068.1 - 4.6e-73 246.2 0.1 8e-48 163.0 0.0 2.1 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 KOH01068.1 - 2.2e-35 121.6 0.2 6.2e-35 120.1 0.0 1.8 2 0 0 2 2 2 1 Aconitase C-terminal domain Suf PF05843.9 KOH01069.1 - 0.17 11.6 18.2 0.047 13.4 0.7 3.4 3 1 1 4 4 4 0 Suppressor of forked protein (Suf) Flavokinase PF01687.12 KOH01070.1 - 4.1e-31 107.4 0.0 7.2e-31 106.6 0.0 1.3 1 1 0 1 1 1 1 Riboflavin kinase Ribosomal_L5_C PF00673.16 KOH01071.1 - 1.6e-24 85.4 0.1 1.3e-23 82.5 0.0 2.2 2 0 0 2 2 2 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 KOH01071.1 - 6.4e-06 25.8 0.0 1.4e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L5 Adaptin_N PF01602.15 KOH01072.1 - 2.1e-117 392.6 10.3 3.2e-117 392.0 7.1 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.1 KOH01072.1 - 8.5e-60 200.1 0.0 2.2e-59 198.8 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.7 KOH01072.1 - 4.7e-51 172.1 1.8 7e-51 171.5 0.1 2.2 2 0 0 2 2 2 1 Coatomer beta C-terminal region HEAT_2 PF13646.1 KOH01072.1 - 3.6e-05 23.9 6.6 0.03 14.6 0.0 4.4 2 1 2 4 4 4 1 HEAT repeats Vac14_Fab1_bd PF12755.2 KOH01072.1 - 0.0058 16.9 0.1 0.031 14.6 0.1 2.3 1 0 0 1 1 1 1 Vacuolar 14 Fab1-binding region DUF247 PF03140.10 KOH01074.1 - 0.0019 17.2 0.0 0.0057 15.7 0.0 1.7 1 0 0 1 1 1 1 Plant protein of unknown function Swi5 PF07061.6 KOH01074.1 - 0.047 13.4 0.3 3 7.6 0.0 2.8 2 0 0 2 2 2 0 Swi5 MSA-2c PF12238.3 KOH01074.1 - 0.15 11.6 5.4 1 8.9 2.4 2.2 2 0 0 2 2 2 0 Merozoite surface antigen 2c DEAD PF00270.24 KOH01075.1 - 1.7e-44 151.2 0.8 4e-41 140.3 0.1 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 KOH01075.1 - 1.9e-27 94.9 0.2 3.9e-27 93.9 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOH01075.1 - 9.2e-05 22.3 0.0 9.2e-05 22.3 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit TPR_11 PF13414.1 KOH01076.1 - 2e-25 88.2 11.0 1.2e-11 44.0 0.1 4.3 2 2 2 4 4 4 4 TPR repeat TPR_1 PF00515.23 KOH01076.1 - 1.3e-21 75.2 2.0 1.1e-06 28.0 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOH01076.1 - 1.1e-19 68.7 1.3 2.9e-05 23.6 0.0 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOH01076.1 - 1.6e-15 56.1 0.3 0.00073 19.9 0.2 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOH01076.1 - 1.9e-15 55.6 4.3 0.0028 17.7 0.0 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOH01076.1 - 3.5e-15 56.1 1.1 1.9e-05 25.1 0.0 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOH01076.1 - 5.2e-11 42.7 1.7 0.0043 17.3 0.0 4.4 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOH01076.1 - 5.3e-09 35.2 3.3 0.23 11.3 0.0 5.2 7 0 0 7 7 5 3 Tetratricopeptide repeat TPR_20 PF14561.1 KOH01076.1 - 1e-08 35.1 0.2 0.066 13.3 0.0 4.5 3 2 2 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOH01076.1 - 4.6e-08 32.8 1.3 8.4e-05 22.4 0.0 3.5 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOH01076.1 - 3.1e-07 30.1 0.2 0.021 14.6 0.0 3.3 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOH01076.1 - 3e-06 27.3 0.2 6.8 7.3 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat Apc3 PF12895.2 KOH01076.1 - 0.00021 21.3 1.6 0.02 15.0 0.3 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOH01076.1 - 0.00043 19.8 0.0 0.37 10.7 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.1 KOH01076.1 - 0.00089 18.4 0.4 0.056 12.4 0.0 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat DUF2989 PF11207.3 KOH01076.1 - 0.017 14.5 0.1 0.049 13.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2989) BTAD PF03704.12 KOH01076.1 - 0.032 14.5 0.0 0.14 12.5 0.0 2.0 1 1 1 2 2 2 0 Bacterial transcriptional activator domain MIT PF04212.13 KOH01076.1 - 0.054 13.3 0.0 14 5.6 0.0 3.2 3 0 0 3 3 2 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.1 KOH01076.1 - 0.088 12.6 0.2 5.1 7.0 0.0 2.9 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat DUF1738 PF08401.6 KOH01076.1 - 0.41 10.3 5.2 0.6 9.8 1.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1738) Glyco_transf_34 PF05637.7 KOH01077.1 - 6.3e-81 271.3 0.1 7.8e-81 271.0 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.9 KOH01077.1 - 0.00076 18.8 0.0 0.053 12.8 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF273 Sybindin PF04099.7 KOH01078.1 - 3.3e-34 117.6 3.5 1.8e-13 50.3 0.2 3.1 3 0 0 3 3 3 3 Sybindin-like family Sedlin_N PF04628.8 KOH01078.1 - 1.2e-06 28.4 0.3 9.6e-06 25.4 0.1 2.0 2 0 0 2 2 2 1 Sedlin, N-terminal conserved region Beta_protein PF14350.1 KOH01078.1 - 0.0041 16.3 0.0 0.0067 15.6 0.0 1.3 1 0 0 1 1 1 1 Beta protein TraU PF06834.6 KOH01078.1 - 0.037 13.1 0.0 0.055 12.5 0.0 1.2 1 0 0 1 1 1 0 TraU protein Pkinase PF00069.20 KOH01079.1 - 1.6e-50 171.7 0.3 2.9e-48 164.2 0.2 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH01079.1 - 1.5e-21 76.6 0.1 3.9e-19 68.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 KOH01079.1 - 2.2e-07 30.1 0.0 7.5e-07 28.3 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 KOH01079.1 - 0.023 14.4 0.1 0.041 13.6 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 KOH01079.1 - 0.067 12.2 0.1 0.16 11.0 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA_18 PF13238.1 KOH01080.1 - 5.8e-09 36.3 0.1 1.1e-08 35.4 0.0 1.4 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.15 KOH01080.1 - 8.2e-09 35.3 0.0 1.1e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_17 PF13207.1 KOH01080.1 - 2.7e-07 31.4 0.0 3.1e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOH01080.1 - 8.2e-05 22.5 0.0 0.0001 22.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain SKI PF01202.17 KOH01080.1 - 0.00012 21.9 0.0 0.00021 21.1 0.0 1.5 1 1 0 1 1 1 1 Shikimate kinase CPT PF07931.7 KOH01080.1 - 0.0063 16.1 0.0 0.01 15.5 0.0 1.4 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.7 KOH01080.1 - 0.0079 15.3 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin NB-ARC PF00931.17 KOH01080.1 - 0.0083 15.0 0.2 0.032 13.1 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain Guanylate_kin PF00625.16 KOH01080.1 - 0.0092 15.4 0.0 0.028 13.8 0.0 1.8 2 0 0 2 2 2 1 Guanylate kinase DUF2075 PF09848.4 KOH01080.1 - 0.0097 14.9 0.1 0.022 13.7 0.0 1.5 1 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.22 KOH01080.1 - 0.013 15.7 0.0 0.014 15.6 0.0 1.3 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.1 KOH01080.1 - 0.013 15.5 0.0 0.021 14.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain NACHT PF05729.7 KOH01080.1 - 0.014 15.0 0.0 0.037 13.6 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.1 KOH01080.1 - 0.017 15.0 0.0 0.021 14.8 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.1 KOH01080.1 - 0.019 14.8 0.0 0.029 14.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOH01080.1 - 0.019 15.1 0.0 0.035 14.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase T2SE PF00437.15 KOH01080.1 - 0.025 13.4 0.0 0.046 12.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.1 KOH01080.1 - 0.027 14.1 0.3 0.046 13.4 0.2 1.6 1 1 0 1 1 1 0 Part of AAA domain AAA PF00004.24 KOH01080.1 - 0.037 14.2 0.0 0.075 13.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 KOH01080.1 - 0.042 13.8 0.2 0.14 12.0 0.0 1.8 2 1 0 2 2 2 0 AAA domain SRP54 PF00448.17 KOH01080.1 - 0.044 13.2 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain KTI12 PF08433.5 KOH01080.1 - 0.047 12.8 0.0 0.098 11.8 0.0 1.5 1 1 0 1 1 1 0 Chromatin associated protein KTI12 CbiA PF01656.18 KOH01080.1 - 0.058 12.7 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF258 PF03193.11 KOH01080.1 - 0.062 12.4 0.0 0.076 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF815 PF05673.8 KOH01080.1 - 0.077 11.9 0.0 0.13 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ArgK PF03308.11 KOH01080.1 - 0.077 11.7 0.4 0.24 10.1 0.1 1.9 2 1 1 3 3 3 0 ArgK protein AAA_25 PF13481.1 KOH01080.1 - 0.088 12.2 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 KOH01080.1 - 0.095 12.4 0.2 0.27 10.9 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B TrwB_AAD_bind PF10412.4 KOH01080.1 - 0.11 11.0 0.0 0.2 10.2 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain ApbA_C PF08546.6 KOH01082.1 - 0.00044 20.2 0.0 0.00076 19.4 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal Ax_dynein_light PF10211.4 KOH01082.1 - 0.014 15.1 8.6 0.058 13.2 0.3 2.5 2 0 0 2 2 2 0 Axonemal dynein light chain NAC PF01849.13 KOH01083.1 - 6.7e-12 44.7 0.0 1.1e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 NAC domain BUD22 PF09073.5 KOH01083.1 - 0.11 11.5 0.2 0.11 11.5 0.2 1.1 1 0 0 1 1 1 0 BUD22 zf-C2H2_4 PF13894.1 KOH01084.1 - 5.6e-11 41.9 3.6 6.7e-05 22.9 0.0 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 KOH01084.1 - 1.1e-10 41.1 7.8 5.3e-05 23.3 1.5 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 KOH01084.1 - 0.00024 21.1 2.2 0.56 10.4 0.0 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding RIG-I_C-RD PF11648.3 KOH01084.1 - 0.0004 20.2 0.4 0.00088 19.1 0.3 1.6 1 0 0 1 1 1 1 C-terminal domain of RIG-I zf-H2C2_2 PF13465.1 KOH01084.1 - 0.0023 18.1 10.4 0.4 11.0 0.1 3.4 3 1 0 3 3 3 2 Zinc-finger double domain zf-H2C2_5 PF13909.1 KOH01084.1 - 0.0076 16.4 1.0 0.0076 16.4 0.7 2.6 2 1 0 2 2 2 1 C2H2-type zinc-finger domain zf-CCHC_5 PF14787.1 KOH01084.1 - 0.02 14.3 0.2 0.07 12.6 0.2 2.0 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-C2H2_6 PF13912.1 KOH01084.1 - 0.031 14.1 4.9 0.77 9.7 1.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-BED PF02892.10 KOH01084.1 - 0.077 12.7 3.2 3.7 7.3 2.2 2.6 1 1 0 1 1 1 0 BED zinc finger RRN7 PF11781.3 KOH01084.1 - 0.11 12.0 0.2 3.1 7.3 0.0 2.4 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 Ribosomal_L20 PF00453.13 KOH01084.1 - 0.12 12.2 1.0 0.28 11.1 0.7 1.7 1 0 0 1 1 1 0 Ribosomal protein L20 zf-RING_3 PF14369.1 KOH01084.1 - 0.34 10.9 1.6 1 9.4 1.2 1.8 1 1 0 1 1 1 0 zinc-finger C1_4 PF07975.7 KOH01084.1 - 0.58 10.2 2.6 1.4 8.9 1.2 2.0 1 1 1 2 2 2 0 TFIIH C1-like domain Zn-ribbon_8 PF09723.5 KOH01084.1 - 1.8 8.5 4.7 15 5.6 2.6 2.3 1 1 0 1 1 1 0 Zinc ribbon domain CENP-N PF05238.8 KOH01085.1 - 1.2e-105 353.9 0.0 1.3e-105 353.7 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like zf-RING_UBOX PF13445.1 KOH01086.1 - 1e-15 57.1 0.6 5.2e-15 54.8 0.4 2.3 1 0 0 1 1 1 1 RING-type zinc-finger CLTH PF10607.4 KOH01086.1 - 1.8e-11 43.9 0.1 1.8e-11 43.9 0.1 2.6 2 1 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_2 PF13639.1 KOH01086.1 - 0.0057 16.4 0.5 0.014 15.1 0.3 1.7 1 0 0 1 1 1 1 Ring finger domain Exonuc_VII_L PF02601.10 KOH01086.1 - 0.026 13.7 5.2 0.035 13.3 3.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Caps_synth_GfcC PF06251.6 KOH01086.1 - 0.063 12.4 0.9 0.14 11.2 0.7 1.6 1 0 0 1 1 1 0 Capsule biosynthesis GfcC zf-RING_5 PF14634.1 KOH01086.1 - 0.088 12.5 0.6 0.28 10.9 0.4 1.8 1 0 0 1 1 1 0 zinc-RING finger domain DUF2058 PF09831.4 KOH01086.1 - 0.098 12.5 7.3 0.17 11.7 5.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) MRP-L51 PF10244.4 KOH01086.1 - 0.64 10.0 6.0 1.1 9.3 3.1 2.0 1 1 1 2 2 2 0 Mitochondrial ribosomal subunit DUF342 PF03961.8 KOH01086.1 - 2.4 6.4 8.4 3.7 5.8 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Tmemb_9 PF05434.6 KOH01086.1 - 3.4 7.4 10.1 0.66 9.7 4.3 1.7 2 0 0 2 2 2 0 TMEM9 Catalase PF00199.14 KOH01087.1 - 1.9e-168 560.1 1.7 2.3e-168 559.7 1.2 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.7 KOH01087.1 - 3.7e-10 39.5 0.0 1.5e-09 37.5 0.0 2.1 2 0 0 2 2 2 1 Catalase-related immune-responsive SET PF00856.23 KOH01088.1 - 2.7e-11 44.0 0.1 6.6e-11 42.7 0.1 1.7 1 1 0 1 1 1 1 SET domain AAA_2 PF07724.9 KOH01089.1 - 6.4e-51 172.6 0.1 1.7e-48 164.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.4 KOH01089.1 - 3.8e-26 90.8 0.3 1.5e-25 88.9 0.2 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.24 KOH01089.1 - 3e-22 79.2 0.0 2.4e-11 43.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOH01089.1 - 1.2e-15 57.4 0.1 9.8e-11 41.5 0.0 3.6 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOH01089.1 - 2.6e-15 56.9 2.3 0.00011 22.1 0.0 4.6 3 2 2 5 5 5 3 AAA ATPase domain AAA_22 PF13401.1 KOH01089.1 - 3.9e-09 36.7 0.0 0.0022 18.1 0.0 3.1 2 0 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 KOH01089.1 - 8.2e-09 35.5 1.0 0.056 13.1 0.0 4.3 2 2 0 3 3 3 2 Archaeal ATPase AAA_14 PF13173.1 KOH01089.1 - 8.3e-08 32.1 0.0 0.02 14.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 KOH01089.1 - 6.1e-07 29.0 0.0 0.048 13.0 0.0 3.3 3 0 0 3 3 3 2 IstB-like ATP binding protein Sigma54_activat PF00158.21 KOH01089.1 - 7.5e-07 28.7 0.1 2.5e-05 23.8 0.0 2.6 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_17 PF13207.1 KOH01089.1 - 5.4e-06 27.2 8.0 0.016 16.0 0.0 4.0 3 1 1 4 4 3 2 AAA domain AAA_18 PF13238.1 KOH01089.1 - 2.7e-05 24.4 5.6 0.054 13.8 0.0 3.4 4 0 0 4 4 2 2 AAA domain MMR_HSR1 PF01926.18 KOH01089.1 - 0.00019 21.3 0.0 0.02 14.8 0.0 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.7 KOH01089.1 - 0.00021 20.9 0.0 0.1 12.2 0.0 2.5 2 0 0 2 2 2 1 NACHT domain ABC_tran PF00005.22 KOH01089.1 - 0.00021 21.5 0.2 0.1 12.8 0.0 3.1 3 0 0 3 3 2 1 ABC transporter Zeta_toxin PF06414.7 KOH01089.1 - 0.00024 20.2 0.1 0.0026 16.9 0.0 2.8 3 1 0 3 3 2 1 Zeta toxin T2SE PF00437.15 KOH01089.1 - 0.00063 18.7 0.2 0.037 12.9 0.1 2.6 2 1 0 2 2 2 1 Type II/IV secretion system protein MobB PF03205.9 KOH01089.1 - 0.00069 19.3 0.0 0.38 10.4 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 KOH01089.1 - 0.0008 19.1 0.0 1.7 8.4 0.0 2.5 2 0 0 2 2 2 2 Part of AAA domain AAA_28 PF13521.1 KOH01089.1 - 0.0011 18.9 0.0 0.45 10.4 0.0 3.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 KOH01089.1 - 0.0012 18.9 0.0 1.5 8.9 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_29 PF13555.1 KOH01089.1 - 0.0015 18.0 0.0 0.29 10.7 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF258 PF03193.11 KOH01089.1 - 0.0022 17.2 0.0 0.4 9.8 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_30 PF13604.1 KOH01089.1 - 0.0023 17.5 0.0 1 8.8 0.0 3.0 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.4 KOH01089.1 - 0.0024 17.3 0.0 0.49 9.8 0.0 2.9 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ResIII PF04851.10 KOH01089.1 - 0.0033 17.2 0.1 4.6 7.0 0.0 3.5 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit UPF0079 PF02367.12 KOH01089.1 - 0.0066 16.0 0.0 1.5 8.4 0.0 2.7 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_25 PF13481.1 KOH01089.1 - 0.0079 15.6 3.6 0.8 9.0 0.0 3.4 3 2 0 3 3 3 1 AAA domain Torsin PF06309.6 KOH01089.1 - 0.0081 16.0 0.0 0.057 13.3 0.0 2.3 2 0 0 2 2 2 1 Torsin AAA_21 PF13304.1 KOH01089.1 - 0.014 15.4 5.4 4.2 7.2 0.0 4.3 3 1 0 3 3 3 0 AAA domain TrwB_AAD_bind PF10412.4 KOH01089.1 - 0.014 14.0 0.0 1.1 7.7 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Mg_chelatase PF01078.16 KOH01089.1 - 0.019 14.1 0.0 1.2 8.2 0.0 2.6 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI SRP54 PF00448.17 KOH01089.1 - 0.025 14.0 0.0 1.7 8.0 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain PhoH PF02562.11 KOH01089.1 - 0.037 13.2 0.0 2.9 7.0 0.0 2.7 2 0 0 2 2 2 0 PhoH-like protein AAA_3 PF07726.6 KOH01089.1 - 0.05 13.2 0.0 1.1 8.9 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 KOH01089.1 - 0.093 12.6 0.0 4.4 7.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_6 PF12774.2 KOH01089.1 - 0.11 12.0 0.1 14 5.1 0.0 2.3 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region D1 ATP_bind_1 PF03029.12 KOH01089.1 - 0.13 11.8 0.0 7 6.1 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein bZIP_1 PF00170.16 KOH01090.1 - 9.3e-11 41.5 4.2 9.3e-11 41.5 2.9 4.0 3 1 1 4 4 4 2 bZIP transcription factor HALZ PF02183.13 KOH01090.1 - 0.0058 16.3 8.1 0.15 11.7 0.4 3.7 1 1 2 3 3 3 2 Homeobox associated leucine zipper Glutaredoxin2_C PF04399.8 KOH01090.1 - 0.25 10.8 5.1 0.55 9.8 1.2 2.8 2 1 1 3 3 3 0 Glutaredoxin 2, C terminal domain DUF1875 PF08961.5 KOH01090.1 - 5.2 6.3 15.7 2.5 7.3 0.8 3.7 2 1 2 4 4 4 0 Domain of unknown function (DUF1875) Rootletin PF15035.1 KOH01090.1 - 6.1 6.7 20.2 12 5.8 6.5 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Apc13p PF05839.6 KOH01091.1 - 5e-26 90.4 1.4 5.5e-26 90.3 0.4 1.5 2 0 0 2 2 2 1 Apc13p protein Cellulase PF00150.13 KOH01092.1 - 2.2e-12 46.7 4.0 2.2e-12 46.7 2.8 2.1 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Fasciclin PF02469.17 KOH01093.1 - 0.033 14.1 0.1 0.073 13.0 0.0 1.6 1 1 0 1 1 1 0 Fasciclin domain XPG_N PF00752.12 KOH01094.1 - 1.7e-26 92.3 0.1 3.5e-26 91.3 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 KOH01094.1 - 8.2e-23 80.2 0.0 2e-22 79.0 0.0 1.7 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.15 KOH01094.1 - 0.00097 19.3 0.0 0.0025 18.0 0.0 1.7 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.2 KOH01094.1 - 0.027 13.9 0.0 0.051 13.0 0.0 1.4 1 0 0 1 1 1 0 XPG domain containing OmpH PF03938.9 KOH01094.1 - 0.029 14.3 0.0 0.31 10.9 0.0 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Ank_2 PF12796.2 KOH01095.1 - 1.2e-37 128.0 0.1 1.6e-18 66.8 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOH01095.1 - 7.6e-33 110.6 0.2 1.2e-08 34.3 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.1 KOH01095.1 - 4.1e-26 90.4 0.3 1.2e-08 34.8 0.1 5.3 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOH01095.1 - 1.4e-25 89.1 0.3 7.2e-09 35.9 0.0 4.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) zf-DHHC PF01529.15 KOH01095.1 - 1.2e-23 83.3 0.7 1.2e-23 83.3 0.5 2.3 1 1 1 2 2 2 1 DHHC palmitoyltransferase Ank_3 PF13606.1 KOH01095.1 - 5.4e-23 78.7 0.4 0.00012 21.9 0.0 6.4 6 0 0 6 6 6 4 Ankyrin repeat Pex2_Pex12 PF04757.9 KOH01096.1 - 1.1e-31 109.9 3.9 1.6e-31 109.5 2.7 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.1 KOH01096.1 - 2.6e-09 36.7 16.7 4.6e-09 35.9 11.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOH01096.1 - 2.6e-08 33.7 17.0 4.8e-08 32.9 11.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOH01096.1 - 4.3e-07 29.4 16.8 6.6e-07 28.9 11.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOH01096.1 - 2.6e-06 26.9 15.4 4.7e-06 26.1 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOH01096.1 - 3.2e-05 23.5 12.6 6e-05 22.6 8.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.2 KOH01096.1 - 0.00092 19.2 8.5 0.0019 18.2 5.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 KOH01096.1 - 0.004 16.8 5.8 0.004 16.8 4.0 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 KOH01096.1 - 0.024 14.5 16.7 0.05 13.4 11.6 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 KOH01097.1 - 2.4e-06 27.0 9.0 2.4e-06 27.0 6.2 3.1 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.27 KOH01098.1 - 4.6e-55 181.6 19.7 4.3e-11 42.2 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat IKI3 PF04762.7 KOH01098.1 - 0.00021 19.3 0.7 0.00027 18.9 0.5 1.1 1 0 0 1 1 1 1 IKI3 family CRT10 PF08728.5 KOH01098.1 - 0.0017 16.4 1.9 0.0032 15.5 0.0 2.1 3 0 0 3 3 3 1 CRT10 eIF2A PF08662.6 KOH01098.1 - 0.0033 17.1 0.7 0.015 14.9 0.0 2.3 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.9 KOH01098.1 - 0.017 13.9 1.0 0.022 13.5 0.2 1.6 2 0 0 2 2 2 0 Coatomer WD associated region AnfO_nitrog PF09582.5 KOH01098.1 - 0.048 12.7 0.0 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) tRNA-synt_1b PF00579.20 KOH01099.1 - 4.4e-84 282.0 0.0 5.7e-84 281.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) E1-E2_ATPase PF00122.15 KOH01100.1 - 2.3e-47 160.9 1.3 2.3e-47 160.9 0.9 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 KOH01100.1 - 2.4e-45 155.6 0.0 3.6e-45 154.9 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 KOH01100.1 - 7.6e-27 93.2 12.4 1.2e-14 54.1 0.4 4.3 5 0 0 5 5 5 3 Heavy-metal-associated domain HAD PF12710.2 KOH01100.1 - 1.3e-16 61.3 0.0 2.6e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KOH01100.1 - 3.1e-07 30.2 0.3 0.0002 21.0 0.1 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOH01100.1 - 0.0037 17.4 0.0 2.1 8.5 0.0 2.6 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Attractin PF08037.6 KOH01100.1 - 0.13 12.0 3.5 0.42 10.4 2.4 1.9 1 0 0 1 1 1 0 Attractin family Lactamase_B PF00753.22 KOH01101.1 - 3.7e-25 88.7 0.1 5.1e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 KOH01101.1 - 4e-06 26.5 0.0 6e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 KOH01101.1 - 0.077 12.7 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Gp-FAR-1 PF05823.7 KOH01101.1 - 0.1 12.5 0.0 0.35 10.8 0.0 1.8 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) CUE PF02845.11 KOH01102.1 - 1.5e-07 30.7 0.0 2.5e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 CUE domain alpha-hel2 PF14456.1 KOH01102.1 - 0.3 9.7 2.0 0.53 9.0 0.0 2.1 2 1 1 3 3 3 0 Alpha-helical domain 2 Pmp3 PF01679.12 KOH01104.1 - 2e-20 72.2 6.0 2.2e-20 72.0 4.2 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator BTP PF05232.7 KOH01104.1 - 0.33 10.7 2.2 0.4 10.4 1.5 1.1 1 0 0 1 1 1 0 Bacterial Transmembrane Pair family FAM220 PF15487.1 KOH01105.1 - 3.7 6.8 11.3 0.062 12.6 1.7 2.2 1 1 1 2 2 2 0 FAM220 family RNase_H2-Ydr279 PF09468.5 KOH01106.1 - 4.8e-49 167.1 0.6 5.8e-49 166.9 0.4 1.0 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) RNase_PH PF01138.16 KOH01107.1 - 1.3e-19 70.8 0.0 2.4e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 KOH01107.1 - 3.4e-12 46.0 0.1 8.4e-12 44.8 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 WTF PF03303.8 KOH01108.1 - 0.048 13.0 0.1 0.048 13.0 0.1 1.8 1 1 1 2 2 2 0 WTF protein ATG27 PF09451.5 KOH01108.1 - 0.15 11.2 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 DUF155 PF02582.9 KOH01109.1 - 1.1e-44 152.4 0.0 1.7e-44 151.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 HGTP_anticodon2 PF12745.2 KOH01110.1 - 9e-100 333.3 4.3 9e-100 333.3 3.0 3.1 3 0 0 3 3 3 1 Anticodon binding domain of tRNAs Pkinase PF00069.20 KOH01110.1 - 1e-73 247.6 2.4 1.8e-44 151.8 0.1 4.3 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 KOH01110.1 - 1.3e-43 148.9 0.3 6.3e-25 87.7 0.0 3.4 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.17 KOH01110.1 - 1.7e-15 56.8 1.3 5.5e-15 55.2 0.9 2.0 1 0 0 1 1 1 1 RWD domain tRNA-synt_His PF13393.1 KOH01110.1 - 2.2e-14 53.2 0.1 9e-14 51.2 0.0 2.0 2 0 0 2 2 2 1 Histidyl-tRNA synthetase SR-25 PF10500.4 KOH01110.1 - 0.0045 16.4 13.1 0.0045 16.4 9.1 3.0 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein APH PF01636.18 KOH01110.1 - 0.015 15.0 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family PAP2 PF01569.16 KOH01111.1 - 2e-21 76.0 3.0 2.6e-21 75.6 1.6 1.5 1 1 0 1 1 1 1 PAP2 superfamily 7TM-7TMR_HD PF07698.6 KOH01111.1 - 2.7 7.3 13.0 0.23 10.8 4.5 2.1 3 0 0 3 3 3 0 7TM receptor with intracellular HD hydrolase AAA_13 PF13166.1 KOH01112.1 - 0.00048 18.7 13.7 0.00048 18.7 9.5 4.2 1 1 2 4 4 4 2 AAA domain Methyltransf_1N PF02870.10 KOH01112.1 - 0.57 10.8 6.5 1.5 9.4 0.0 3.9 4 0 0 4 4 4 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain ATG16 PF08614.6 KOH01112.1 - 4.9 6.9 94.8 0.012 15.5 11.6 5.7 2 2 3 5 5 5 0 Autophagy protein 16 (ATG16) DUF836 PF05768.9 KOH01113.1 - 1e-17 64.1 0.3 1.3e-17 63.8 0.2 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.19 KOH01113.1 - 3.2e-05 23.8 0.0 0.00012 21.9 0.0 2.0 2 1 0 2 2 2 1 Glutaredoxin Thioredoxin_2 PF13098.1 KOH01113.1 - 0.00021 21.4 0.5 0.00028 21.0 0.3 1.3 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.16 KOH01113.1 - 0.0016 18.1 0.1 0.0021 17.7 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KOH01113.1 - 0.0032 17.0 0.0 0.0038 16.7 0.0 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.1 KOH01113.1 - 0.0058 16.7 0.2 0.0075 16.3 0.2 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_4 PF13462.1 KOH01113.1 - 0.04 13.9 0.2 0.057 13.4 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin Inositol_P PF00459.20 KOH01114.1 - 1.5e-71 240.8 0.0 1.7e-71 240.6 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family MAGE PF01454.14 KOH01115.1 - 1.6e-42 145.0 0.2 2.1e-42 144.6 0.1 1.1 1 0 0 1 1 1 1 MAGE family DUF387 PF04079.11 KOH01115.1 - 0.029 13.7 0.5 0.47 9.8 0.0 2.5 2 1 1 3 3 3 0 Putative transcriptional regulators (Ypuh-like) CTD_bind PF04818.8 KOH01116.1 - 2e-19 69.5 0.2 4.7e-19 68.3 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CTK3 PF12243.3 KOH01116.1 - 0.0067 16.0 0.4 0.015 14.9 0.3 1.6 1 1 0 1 1 1 1 CTD kinase subunit gamma CTK3 DNase_II PF03265.10 KOH01116.1 - 0.062 12.2 0.2 0.11 11.5 0.1 1.3 1 0 0 1 1 1 0 Deoxyribonuclease II IncA PF04156.9 KOH01116.1 - 2.1 7.9 6.6 25 4.4 4.2 2.4 1 1 0 1 1 1 0 IncA protein DEAD PF00270.24 KOH01117.1 - 2e-23 82.7 0.0 5.5e-23 81.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF1998 PF09369.5 KOH01117.1 - 5.7e-15 55.6 0.1 1.7e-14 54.1 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.26 KOH01117.1 - 2.6e-12 46.4 0.0 1.2e-11 44.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CDT1 PF08839.6 KOH01117.1 - 0.0028 17.5 0.3 0.013 15.4 0.3 2.0 2 0 0 2 2 2 1 DNA replication factor CDT1 like TFR_dimer PF04253.10 KOH01117.1 - 0.0079 15.7 0.0 0.021 14.3 0.0 1.7 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain SRX PF09201.5 KOH01118.1 - 5e-65 217.6 4.9 1.2e-64 216.4 3.4 1.7 1 0 0 1 1 1 1 SRX SRP54 PF00448.17 KOH01118.1 - 1.3e-47 161.7 0.1 2.5e-45 154.3 0.1 2.4 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.14 KOH01118.1 - 1.6e-06 28.1 1.2 5.4e-06 26.4 0.1 2.5 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain CbiA PF01656.18 KOH01118.1 - 6e-06 25.7 0.0 2e-05 24.1 0.0 1.9 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArgK PF03308.11 KOH01118.1 - 0.00059 18.6 0.1 0.0021 16.8 0.0 2.0 2 1 0 2 2 2 1 ArgK protein AAA_22 PF13401.1 KOH01118.1 - 0.0022 18.1 0.2 0.019 15.0 0.0 2.7 3 1 0 3 3 3 1 AAA domain ArsA_ATPase PF02374.10 KOH01118.1 - 0.0044 16.0 0.0 0.17 10.8 0.0 2.7 2 0 0 2 2 2 1 Anion-transporting ATPase MobB PF03205.9 KOH01118.1 - 0.005 16.5 0.0 0.019 14.6 0.0 2.0 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Fer4_NifH PF00142.13 KOH01118.1 - 0.015 14.5 0.0 0.035 13.2 0.0 1.7 1 1 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_16 PF13191.1 KOH01118.1 - 0.028 14.4 0.0 0.089 12.7 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.1 KOH01118.1 - 0.033 14.0 0.0 0.55 10.1 0.0 2.7 1 1 1 2 2 2 0 AAA domain RNB PF00773.14 KOH01119.1 - 1.5e-57 195.3 0.0 1.5e-57 195.3 0.0 1.9 2 0 0 2 2 2 1 RNB domain OB_RNB PF08206.6 KOH01119.1 - 0.00095 18.6 0.1 0.7 9.4 0.0 2.7 2 0 0 2 2 2 2 Ribonuclease B OB domain SseC PF04888.7 KOH01119.1 - 0.36 10.1 4.9 0.67 9.2 3.4 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Pyridoxal_deC PF00282.14 KOH01120.1 - 1.1e-24 86.6 0.0 1.7e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 KOH01120.1 - 2.1e-09 36.6 0.0 1.1e-08 34.2 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 KOH01120.1 - 1e-07 31.3 0.0 1.7e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 KOH01120.1 - 0.019 13.2 0.0 0.028 12.7 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme SLA_LP_auto_ag PF05889.8 KOH01120.1 - 0.14 10.5 0.0 0.2 10.0 0.0 1.2 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Beta_elim_lyase PF01212.16 KOH01120.1 - 0.15 11.1 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase HDA2-3 PF11496.3 KOH01121.1 - 5.4e-84 281.5 9.3 5.4e-84 281.5 6.4 2.3 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 USP8_interact PF08941.5 KOH01121.1 - 0.067 12.5 0.2 0.14 11.4 0.2 1.5 1 0 0 1 1 1 0 USP8 interacting Spc7 PF08317.6 KOH01121.1 - 0.45 9.1 27.4 0.05 12.2 5.0 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein APC_crr PF05923.7 KOH01121.1 - 0.86 9.3 8.7 3.7 7.3 3.8 3.3 3 0 0 3 3 3 0 APC cysteine-rich region Mhr1 PF12829.2 KOH01122.1 - 4e-36 122.7 3.0 7.5e-36 121.8 2.1 1.4 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination FA_hydroxylase PF04116.8 KOH01123.1 - 5.3e-15 55.8 12.8 5.3e-15 55.8 8.9 2.3 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily OSCP PF00213.13 KOH01124.1 - 5e-42 143.6 0.7 5.9e-42 143.4 0.5 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit AATF-Che1 PF13339.1 KOH01125.1 - 1.2e-29 103.1 8.5 1.2e-29 103.1 5.9 3.1 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor TRAUB PF08164.7 KOH01125.1 - 3.9e-28 97.3 0.1 3.9e-28 97.3 0.1 3.5 3 1 0 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal AA_kinase PF00696.23 KOH01126.1 - 1.1e-34 120.0 0.6 2.9e-34 118.6 0.2 1.7 2 0 0 2 2 2 1 Amino acid kinase family PUA PF01472.15 KOH01126.1 - 6.4e-21 73.8 0.0 1.4e-20 72.7 0.0 1.6 1 0 0 1 1 1 1 PUA domain CPSF_A PF03178.10 KOH01127.1 - 2.1e-83 280.0 0.5 7.9e-83 278.1 0.0 2.3 2 0 0 2 2 2 1 CPSF A subunit region PIG-F PF06699.6 KOH01128.1 - 2.2e-41 141.9 22.2 1.2e-40 139.5 15.4 1.8 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F Gly-zipper_Omp PF13488.1 KOH01128.1 - 0.17 11.5 2.4 0.3 10.7 1.7 1.4 1 0 0 1 1 1 0 Glycine zipper Zn_clus PF00172.13 KOH01129.1 - 1.7e-08 34.2 6.5 3.4e-08 33.2 4.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pro_isomerase PF00160.16 KOH01130.1 - 6.8e-43 146.5 0.3 9.1e-43 146.1 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HIT PF01230.18 KOH01131.1 - 3.8e-14 53.0 0.0 6.4e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 KOH01131.1 - 0.023 14.9 0.1 0.042 14.0 0.0 1.4 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding F-box-like PF12937.2 KOH01132.1 - 0.013 15.1 0.0 0.013 15.1 0.0 2.7 3 0 0 3 3 3 0 F-box-like LRR_5 PF13306.1 KOH01132.1 - 0.37 10.4 11.2 0.9 9.2 1.3 3.4 1 1 2 3 3 3 0 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOH01132.1 - 1.2 8.8 5.5 10 5.9 0.3 4.1 3 1 3 6 6 6 0 Leucine rich repeat MIR PF02815.14 KOH01133.1 - 9.3e-08 31.8 0.0 7.9e-07 28.7 0.0 2.1 1 1 1 2 2 2 1 MIR domain PMT PF02366.13 KOH01133.1 - 0.0045 16.3 16.7 0.0045 16.3 11.6 2.7 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Med21 PF11221.3 KOH01134.1 - 6.7e-50 168.8 3.9 7.5e-50 168.6 2.7 1.0 1 0 0 1 1 1 1 Subunit 21 of Mediator complex TMCO5 PF14992.1 KOH01134.1 - 0.00098 18.3 1.1 0.0012 18.0 0.8 1.2 1 0 0 1 1 1 1 TMCO5 family Med9 PF07544.8 KOH01134.1 - 0.0013 18.4 1.9 0.0054 16.4 1.2 2.0 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Spore_III_AB PF09548.5 KOH01134.1 - 0.0051 16.5 0.7 0.0061 16.3 0.5 1.3 1 0 0 1 1 1 1 Stage III sporulation protein AB (spore_III_AB) DUF2200 PF09966.4 KOH01134.1 - 0.047 13.5 0.4 0.58 10.0 0.0 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2200) eIF2_C PF09173.6 KOH01134.1 - 0.092 12.8 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 Initiation factor eIF2 gamma, C terminal STAT_alpha PF01017.15 KOH01134.1 - 0.4 10.3 4.1 2.2 7.9 0.6 2.0 1 1 1 2 2 2 0 STAT protein, all-alpha domain MscL PF01741.13 KOH01134.1 - 1.2 9.2 3.9 1.6 8.8 1.6 1.7 1 1 1 2 2 2 0 Large-conductance mechanosensitive channel, MscL SlyX PF04102.7 KOH01134.1 - 8.2 6.8 8.6 10 6.5 0.1 3.2 2 2 1 3 3 3 0 SlyX PBD PF00786.23 KOH01135.1 - 1.2e-05 25.5 2.1 1.2e-05 25.5 1.5 3.2 3 1 0 3 3 3 1 P21-Rho-binding domain TFIIH_BTF_p62_N PF08567.6 KOH01137.1 - 4e-24 84.0 0.3 9.7e-24 82.8 0.2 1.7 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.12 KOH01137.1 - 7.9e-24 83.1 2.4 7.1e-13 48.0 0.5 2.7 2 0 0 2 2 2 2 BSD domain Brix PF04427.13 KOH01138.1 - 1.8e-61 207.1 3.8 2.6e-61 206.6 2.7 1.3 1 0 0 1 1 1 1 Brix domain DUF1223 PF06764.6 KOH01138.1 - 0.44 10.3 5.4 1 9.1 3.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) DUF2514 PF10721.4 KOH01138.1 - 6.4 6.4 16.2 0.047 13.3 4.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) FYVE PF01363.16 KOH01139.1 - 7.7e-20 70.5 14.3 7.7e-20 70.5 9.9 3.4 3 1 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.1 KOH01139.1 - 4.8e-10 39.1 2.3 4.8e-10 39.1 1.6 4.4 3 2 3 6 6 6 1 Ring finger domain zf-RING_UBOX PF13445.1 KOH01139.1 - 0.0012 18.5 2.2 0.0012 18.5 1.5 4.7 4 1 1 5 5 5 1 RING-type zinc-finger zf-C3HC4 PF00097.20 KOH01139.1 - 0.0033 17.0 3.5 0.0033 17.0 2.4 5.2 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOH01139.1 - 0.0068 16.4 3.3 0.0068 16.4 2.3 5.0 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.3 KOH01139.1 - 0.0093 15.9 2.2 0.0093 15.9 1.5 3.7 4 0 0 4 4 4 1 FANCL C-terminal domain zf-ribbon_3 PF13248.1 KOH01139.1 - 0.035 13.3 1.0 0.035 13.3 0.7 4.8 5 1 0 5 5 5 0 zinc-ribbon domain RINGv PF12906.2 KOH01139.1 - 0.039 14.0 2.4 0.039 14.0 1.7 4.3 4 1 1 5 5 5 0 RING-variant domain zinc_ribbon_2 PF13240.1 KOH01139.1 - 0.045 13.2 1.0 0.045 13.2 0.7 5.1 6 1 0 6 6 5 0 zinc-ribbon domain zf-RING_5 PF14634.1 KOH01139.1 - 0.16 11.7 32.1 0.092 12.4 2.8 5.3 5 0 0 5 5 5 0 zinc-RING finger domain zf-C3HC4_4 PF15227.1 KOH01139.1 - 0.8 9.6 24.3 0.66 9.9 1.3 5.1 4 2 0 4 4 4 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 KOH01139.1 - 5.7 7.1 28.1 0.1 12.7 3.4 3.9 3 2 0 3 3 3 0 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 KOH01139.1 - 8.7 6.1 30.9 1.1 9.0 1.9 4.9 4 1 1 5 5 5 0 Zinc finger, C3HC4 type (RING finger) BHD_1 PF10403.4 KOH01140.1 - 6e-10 38.4 0.1 2.9e-09 36.2 0.0 2.2 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 KOH01140.1 - 1.6e-09 37.9 0.1 5.8e-09 36.1 0.1 2.1 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 2 BHD_3 PF10405.4 KOH01140.1 - 3.3e-09 36.3 0.1 7.7e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 Rad4 PF03835.10 KOH01140.1 - 2.8e-05 23.5 0.2 0.00011 21.6 0.2 2.0 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain DUF4367 PF14285.1 KOH01140.1 - 0.067 12.5 1.2 0.16 11.3 0.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) Ins_P5_2-kin PF06090.7 KOH01141.1 - 3.2e-49 167.6 2.6 1.2e-48 165.7 1.8 1.7 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase NAAA-beta PF15508.1 KOH01141.1 - 0.08 13.3 0.1 4.8 7.5 0.0 2.5 2 0 0 2 2 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Methyltransf_23 PF13489.1 KOH01142.1 - 3e-15 56.2 0.0 5.2e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOH01142.1 - 1.4e-14 54.3 0.2 7.9e-14 51.9 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOH01142.1 - 1e-09 37.9 1.2 6.1e-08 32.0 0.1 2.6 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 KOH01142.1 - 1.6e-08 34.8 0.0 1.1e-07 32.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOH01142.1 - 1.8e-07 31.4 0.0 4.8e-07 30.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOH01142.1 - 4.3e-07 29.6 0.1 1.6e-06 27.7 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOH01142.1 - 1.2e-05 25.8 0.0 2.9e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain HIM1 PF08732.5 KOH01143.1 - 1.3e-144 481.7 0.2 1.4e-144 481.5 0.2 1.0 1 0 0 1 1 1 1 HIM1 CENP-O PF09496.5 KOH01144.1 - 9.6e-21 73.8 0.1 2.4e-20 72.5 0.0 1.7 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component AAA_13 PF13166.1 KOH01144.1 - 0.0023 16.4 1.3 0.0034 15.9 0.9 1.2 1 0 0 1 1 1 1 AAA domain CENP-F_leu_zip PF10473.4 KOH01144.1 - 0.0065 16.3 2.1 0.014 15.2 1.4 1.6 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc24 PF08286.6 KOH01144.1 - 0.024 14.3 3.1 0.084 12.5 1.1 2.4 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 HeLo PF14479.1 KOH01144.1 - 0.035 13.8 2.6 0.78 9.4 1.8 2.3 1 1 0 1 1 1 0 Prion-inhibition and propagation Prefoldin_2 PF01920.15 KOH01144.1 - 0.11 12.3 5.8 0.28 10.9 3.4 2.1 2 0 0 2 2 2 0 Prefoldin subunit IncA PF04156.9 KOH01144.1 - 0.21 11.1 2.6 0.49 9.9 1.8 1.5 1 0 0 1 1 1 0 IncA protein Pup PF05639.6 KOH01144.1 - 0.94 10.0 4.3 25 5.4 0.3 3.3 3 0 0 3 3 3 0 Pup-like protein Scs3p PF10261.4 KOH01145.1 - 2e-37 128.5 19.2 4.7e-37 127.3 13.3 1.6 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Orai-1 PF07856.7 KOH01145.1 - 0.22 11.0 4.8 0.52 9.8 3.3 1.6 1 0 0 1 1 1 0 Mediator of CRAC channel activity PAP2 PF01569.16 KOH01145.1 - 0.47 10.1 14.4 0.36 10.5 5.3 2.6 3 1 0 3 3 3 0 PAP2 superfamily Ubiq-assoc PF09145.5 KOH01146.1 - 9.5e-24 82.9 0.8 3.3e-23 81.2 0.5 1.9 1 0 0 1 1 1 1 Ubiquitin-associated TPR_11 PF13414.1 KOH01146.1 - 4.1e-08 32.7 0.0 8.9e-06 25.2 0.0 2.6 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.1 KOH01146.1 - 4.9e-06 26.3 0.0 0.00023 21.0 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOH01146.1 - 0.00021 20.7 0.1 6.2 6.5 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOH01146.1 - 0.00064 19.4 0.0 2.8 8.0 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat DnaJ PF00226.26 KOH01146.1 - 0.0095 15.6 0.1 0.024 14.3 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Colicin PF01024.14 KOH01146.1 - 0.034 13.7 0.1 0.063 12.8 0.1 1.4 1 0 0 1 1 1 0 Colicin pore forming domain DASH_Dad4 PF08650.5 KOH01147.1 - 1e-38 131.0 6.2 1.1e-38 130.9 4.3 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 DUF3251 PF11622.3 KOH01147.1 - 0.059 12.7 0.4 0.071 12.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) NPV_P10 PF05531.7 KOH01147.1 - 0.09 13.0 0.4 0.1 12.8 0.3 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DivIC PF04977.10 KOH01147.1 - 0.094 12.2 0.8 0.14 11.6 0.5 1.3 1 0 0 1 1 1 0 Septum formation initiator Asparaginase PF00710.15 KOH01148.1 - 7.7e-74 248.3 0.0 9.5e-74 248.0 0.0 1.1 1 0 0 1 1 1 1 Asparaginase Ribosomal_L19 PF01245.15 KOH01148.1 - 0.021 14.5 0.0 2.9 7.7 0.0 2.6 2 1 0 2 2 2 0 Ribosomal protein L19 PBP PF01161.15 KOH01149.1 - 2.9e-13 49.8 0.0 5.6e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein ATP-synt_E PF05680.7 KOH01150.1 - 6.6e-19 67.6 0.0 7.2e-19 67.5 0.0 1.1 1 0 0 1 1 1 1 ATP synthase E chain DUF1179 PF06678.6 KOH01150.1 - 0.062 13.6 0.0 0.063 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1179) FYVE PF01363.16 KOH01151.1 - 5.1e-20 71.1 19.1 4.9e-16 58.3 0.9 3.3 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.3 KOH01151.1 - 0.0005 19.5 0.9 0.0005 19.5 0.6 2.6 2 0 0 2 2 2 1 Rabenosyn Rab binding domain zf-C2H2_4 PF13894.1 KOH01151.1 - 0.0048 17.1 0.1 0.0048 17.1 0.1 5.3 5 2 0 5 5 3 1 C2H2-type zinc finger zf-Di19 PF05605.7 KOH01151.1 - 0.015 15.3 0.1 0.015 15.3 0.1 2.7 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 KOH01151.1 - 0.044 14.1 0.1 0.044 14.1 0.1 5.7 5 1 1 6 6 4 0 Zinc finger, C2H2 type HypA PF01155.14 KOH01151.1 - 0.26 10.9 6.9 2.5 7.7 1.5 3.0 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family RPAP2_Rtr1 PF04181.8 KOH01151.1 - 1.7 8.7 8.4 0.9 9.6 0.2 3.0 2 0 0 2 2 2 0 Rtr1/RPAP2 family DZR PF12773.2 KOH01151.1 - 2.8 7.8 21.4 0.1 12.4 1.6 4.1 5 0 0 5 5 4 0 Double zinc ribbon CorA PF01544.13 KOH01151.1 - 3.8 6.4 10.1 0.4 9.6 0.5 2.5 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein zf-met PF12874.2 KOH01151.1 - 4.4 7.6 12.7 1.1 9.6 0.1 4.1 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Prok-RING_1 PF14446.1 KOH01151.1 - 6.2 6.6 16.3 0.18 11.5 2.2 3.7 3 1 1 4 4 4 0 Prokaryotic RING finger family 1 WD40 PF00400.27 KOH01152.1 - 1.7e-13 49.9 15.2 0.038 13.8 0.1 8.5 9 0 0 9 9 9 6 WD domain, G-beta repeat Cnd3 PF12719.2 KOH01153.1 - 3.8e-99 331.4 8.2 1.9e-98 329.1 3.1 2.6 3 0 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.1 KOH01153.1 - 6.2e-09 36.0 0.1 0.00037 20.7 0.0 3.5 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.17 KOH01153.1 - 3.3e-05 23.5 0.9 0.83 9.9 0.0 5.2 5 0 0 5 5 5 2 HEAT repeat GRAM PF02893.15 KOH01154.1 - 5.8e-18 64.1 0.0 1.4e-17 62.9 0.0 1.7 1 0 0 1 1 1 1 GRAM domain TRP PF06011.7 KOH01154.1 - 0.035 12.7 1.5 0.094 11.2 1.0 1.7 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Methyltransf_12 PF08242.7 KOH01154.1 - 9.1 6.8 10.8 0.16 12.4 0.3 3.5 4 0 0 4 4 4 0 Methyltransferase domain Skp1 PF01466.14 KOH01155.1 - 6.8e-37 125.3 0.2 1.1e-36 124.6 0.2 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 KOH01155.1 - 9.4e-14 51.2 0.1 5.4e-06 26.3 0.0 2.4 2 0 0 2 2 2 2 Skp1 family, tetramerisation domain GCIP PF13324.1 KOH01155.1 - 0.0077 15.4 6.2 0.011 14.9 4.3 1.2 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting DUF4642 PF15484.1 KOH01155.1 - 0.033 14.1 1.9 0.052 13.5 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4642) Ebola_NP PF05505.7 KOH01155.1 - 0.26 9.3 7.4 0.32 9.0 5.1 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein CDC45 PF02724.9 KOH01155.1 - 0.79 7.6 15.7 0.94 7.4 10.6 1.4 1 1 0 1 1 1 0 CDC45-like protein SDA1 PF05285.7 KOH01155.1 - 1.6 7.9 11.8 2.2 7.4 8.2 1.2 1 0 0 1 1 1 0 SDA1 DUF3245 PF11595.3 KOH01155.1 - 4.4 7.5 21.1 0.27 11.4 8.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3245) CENP-B_dimeris PF09026.5 KOH01155.1 - 7.7 6.8 24.9 0.63 10.3 10.3 2.3 1 1 1 2 2 2 0 Centromere protein B dimerisation domain Peroxin-3 PF04882.7 KOH01156.1 - 6.9e-104 347.9 20.8 1.1e-103 347.2 14.4 1.3 1 1 0 1 1 1 1 Peroxin-3 Thioredoxin_7 PF13899.1 KOH01157.1 - 8.3e-21 73.8 0.1 1.6e-20 72.8 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.15 KOH01157.1 - 7.5e-18 64.3 0.0 1.5e-17 63.3 0.0 1.6 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.1 KOH01157.1 - 4.8e-14 51.6 0.4 9.8e-14 50.6 0.3 1.6 1 0 0 1 1 1 1 UBA-like domain C2-set PF05790.10 KOH01157.1 - 0.00067 19.5 0.2 0.0019 18.1 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin C2-set domain Peptidase_C13 PF01650.13 KOH01158.1 - 1.1e-46 159.2 1.1 1.7e-46 158.6 0.7 1.2 1 0 0 1 1 1 1 Peptidase C13 family RNA_binding PF01877.12 KOH01158.1 - 0.034 14.1 1.3 0.21 11.6 0.1 2.4 2 1 0 2 2 2 0 RNA binding ResIII PF04851.10 KOH01159.1 - 2.4e-24 86.2 1.2 6.8e-24 84.7 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 KOH01159.1 - 6.7e-18 64.7 0.8 1.4e-17 63.7 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOH01159.1 - 2.5e-14 52.8 0.0 9.1e-14 51.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 KOH01159.1 - 0.00026 21.1 0.0 0.00092 19.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain Helicase_C_2 PF13307.1 KOH01159.1 - 0.0037 17.2 1.5 0.0092 15.9 0.0 2.4 3 0 0 3 3 3 1 Helicase C-terminal domain Tcf25 PF04910.9 KOH01160.1 - 1.8e-80 270.5 1.7 1.8e-80 270.5 1.2 1.5 2 0 0 2 2 2 1 Transcriptional repressor TCF25 NST1 PF13945.1 KOH01160.1 - 0.7 9.9 13.3 0.21 11.6 7.1 1.6 1 1 0 1 1 1 0 Salt tolerance down-regulator FLO_LFY PF01698.11 KOH01160.1 - 2.7 6.7 11.2 4.2 6.1 7.8 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein SNF2_N PF00176.18 KOH01161.1 - 1.6e-77 260.2 0.9 3.9e-77 259.0 0.6 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain HSA PF07529.8 KOH01161.1 - 1.1e-16 60.3 7.6 1.1e-16 60.3 5.3 3.2 2 1 1 3 3 3 1 HSA Helicase_C PF00271.26 KOH01161.1 - 2e-14 53.2 0.0 8.9e-14 51.1 0.0 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOH01161.1 - 1e-06 28.3 0.0 3.2e-06 26.7 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Xpo1 PF08389.7 KOH01162.1 - 1.2 9.0 14.4 1 9.2 6.5 3.4 2 1 0 2 2 2 0 Exportin 1-like protein MMR_HSR1 PF01926.18 KOH01163.1 - 2.5e-14 53.2 0.1 4.2e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOH01163.1 - 2.5e-06 26.8 0.1 3.6e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.11 KOH01163.1 - 0.00033 19.8 0.2 0.00067 18.8 0.0 1.7 2 0 0 2 2 2 1 AIG1 family DUF258 PF03193.11 KOH01163.1 - 0.00042 19.5 0.1 0.00076 18.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SRPRB PF09439.5 KOH01163.1 - 0.0028 16.9 0.2 0.0058 15.8 0.1 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.18 KOH01163.1 - 0.0031 17.3 2.1 1.3 8.7 0.0 2.5 2 1 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.22 KOH01163.1 - 0.075 12.4 0.4 0.81 9.0 0.3 2.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Ribosomal_S15 PF00312.17 KOH01164.1 - 3.5e-30 103.6 0.1 8.1e-30 102.4 0.1 1.7 1 0 0 1 1 1 1 Ribosomal protein S15 DUF3487 PF11990.3 KOH01164.1 - 0.067 12.6 0.2 0.11 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) GN3L_Grn1 PF08701.6 KOH01164.1 - 0.45 10.4 10.2 0.66 9.9 0.3 3.0 3 0 0 3 3 3 0 GNL3L/Grn1 putative GTPase MatE PF01554.13 KOH01165.1 - 1.3e-59 200.4 26.9 1.3e-36 125.6 4.8 3.0 4 0 0 4 4 4 2 MatE Fcf1 PF04900.7 KOH01166.1 - 1.4e-37 127.7 1.0 1.8e-37 127.4 0.1 1.6 2 0 0 2 2 2 1 Fcf1 tRNA-synt_1d PF00750.14 KOH01167.1 - 1.2e-103 346.6 5.1 1.5e-103 346.3 3.5 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 KOH01167.1 - 1.3e-29 102.5 0.1 3.1e-28 98.1 0.0 2.4 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 KOH01167.1 - 1.8e-09 37.9 0.0 1.5e-08 35.0 0.0 2.5 3 0 0 3 3 3 1 Arginyl tRNA synthetase N terminal domain Svf1 PF08622.5 KOH01169.1 - 9.5e-137 455.3 2.1 1.2e-136 455.0 1.5 1.1 1 0 0 1 1 1 1 Svf1-like Sigma70_ner PF04546.8 KOH01169.1 - 0.36 10.4 17.5 0.22 11.0 4.9 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region Prothymosin PF03247.9 KOH01169.1 - 0.88 9.7 35.7 4.1 7.5 14.7 2.4 2 0 0 2 2 2 0 Prothymosin/parathymosin family TRAP_alpha PF03896.11 KOH01169.1 - 4.4 6.2 13.5 0.43 9.5 2.1 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.1 KOH01169.1 - 8 6.1 11.4 7.1 6.2 2.7 2.5 2 0 0 2 2 2 0 FAM176 family Sod_Fe_C PF02777.13 KOH01170.1 - 1.4e-08 34.5 0.1 0.00099 18.9 0.0 2.5 1 1 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Pal1 PF08316.6 KOH01171.1 - 2.3e-55 186.8 2.5 2.3e-55 186.8 1.7 3.0 4 1 0 4 4 4 1 Pal1 cell morphology protein Asp PF00026.18 KOH01172.1 - 4.6e-25 88.5 0.2 4.6e-25 88.5 0.2 3.0 2 2 0 2 2 2 1 Eukaryotic aspartyl protease PQ-loop PF04193.9 KOH01175.1 - 1.4e-36 123.8 11.7 1.1e-18 66.4 0.8 2.5 2 0 0 2 2 2 2 PQ loop repeat DUF679 PF05078.7 KOH01175.1 - 0.0085 15.7 0.0 0.057 13.0 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF679) MtN3_slv PF03083.11 KOH01175.1 - 0.083 12.7 7.1 0.33 10.8 0.3 3.4 2 1 1 3 3 3 0 Sugar efflux transporter for intercellular exchange CARD PF00619.16 KOH01175.1 - 0.18 11.6 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 Caspase recruitment domain Pyr_redox_2 PF07992.9 KOH01176.1 - 3.3e-29 102.2 0.1 3.9e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOH01176.1 - 2.5e-17 63.0 0.1 8.8e-15 54.8 0.0 2.6 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOH01176.1 - 5.5e-09 36.3 0.0 1.3e-06 28.6 0.0 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 KOH01176.1 - 5.3e-06 25.5 0.6 0.44 9.3 0.1 4.0 4 0 0 4 4 4 2 Glucose inhibited division protein A NAD_binding_7 PF13241.1 KOH01176.1 - 0.00025 21.2 0.0 0.066 13.4 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_8 PF13450.1 KOH01176.1 - 0.00029 20.7 0.0 0.021 14.8 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 KOH01176.1 - 0.0011 18.1 0.1 0.01 14.9 0.0 2.3 2 0 0 2 2 2 1 Thi4 family Shikimate_DH PF01488.15 KOH01176.1 - 0.0015 18.6 0.2 0.62 10.1 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase DAO PF01266.19 KOH01176.1 - 0.0024 16.8 0.1 3.3 6.5 0.0 2.9 3 0 0 3 3 3 2 FAD dependent oxidoreductase K_oxygenase PF13434.1 KOH01176.1 - 0.0054 15.7 0.1 0.63 8.8 0.0 3.2 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.19 KOH01176.1 - 0.0072 15.2 1.4 1 8.1 0.2 2.5 2 1 0 2 2 2 2 FAD binding domain NAD_Gly3P_dh_N PF01210.18 KOH01176.1 - 0.023 14.4 0.1 7.4 6.2 0.1 2.4 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.14 KOH01176.1 - 0.025 13.6 0.1 4 6.3 0.1 2.2 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.9 KOH01176.1 - 0.069 11.6 0.3 1.9 6.8 0.1 2.6 2 1 1 3 3 3 0 HI0933-like protein NAD_binding_9 PF13454.1 KOH01176.1 - 0.11 12.2 0.0 6.9 6.4 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding FMO-like PF00743.14 KOH01176.1 - 0.12 10.5 0.0 0.16 10.1 0.0 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Glycos_transf_3 PF00591.16 KOH01177.1 - 1.4e-85 286.7 0.0 1.8e-85 286.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.12 KOH01177.1 - 1.9e-15 56.1 0.0 4e-15 55.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain NOG1 PF06858.9 KOH01177.1 - 0.13 12.1 0.1 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) Filament PF00038.16 KOH01178.1 - 4.6e-08 32.9 136.1 0.00072 19.1 29.9 6.0 1 1 4 5 5 5 4 Intermediate filament protein Reo_sigmaC PF04582.7 KOH01178.1 - 4.1e-05 22.9 52.5 0.00042 19.5 4.1 5.2 3 1 2 5 5 5 3 Reovirus sigma C capsid protein Tropomyosin PF00261.15 KOH01178.1 - 0.00012 21.2 49.2 0.00012 21.2 34.1 7.1 1 1 4 5 5 5 2 Tropomyosin HOOK PF05622.7 KOH01178.1 - 0.00087 17.2 47.1 0.00087 17.2 32.6 4.2 1 1 3 4 4 4 2 HOOK protein LMBR1 PF04791.11 KOH01178.1 - 0.047 12.2 0.1 0.047 12.2 0.1 5.6 1 1 2 5 5 3 0 LMBR1-like membrane protein HrpB7 PF09486.5 KOH01178.1 - 0.14 12.0 48.5 0.063 13.1 6.2 7.2 3 2 2 6 6 6 0 Bacterial type III secretion protein (HrpB7) IncA PF04156.9 KOH01178.1 - 0.22 11.1 155.8 0.67 9.5 9.3 8.0 1 1 6 7 7 7 0 IncA protein Surfac_D-trimer PF09006.6 KOH01178.1 - 0.65 9.7 5.1 27 4.5 0.1 4.2 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation Spc7 PF08317.6 KOH01178.1 - 0.84 8.2 149.6 0.13 10.9 19.5 6.4 1 1 6 8 8 8 0 Spc7 kinetochore protein Mnd1 PF03962.10 KOH01178.1 - 1.4 8.5 132.9 0.47 10.1 8.5 8.1 1 1 6 8 8 7 0 Mnd1 family TPR_MLP1_2 PF07926.7 KOH01178.1 - 6.1 6.5 162.3 0.46 10.2 13.5 8.7 1 1 6 7 7 7 0 TPR/MLP1/MLP2-like protein Rep_2 PF01719.12 KOH01179.1 - 0.15 11.5 2.7 0.19 11.1 1.9 1.2 1 0 0 1 1 1 0 Plasmid replication protein VHS PF00790.14 KOH01180.1 - 2.2e-48 163.4 0.0 6.5e-48 161.9 0.0 1.8 2 0 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.15 KOH01180.1 - 1.2e-16 61.0 0.2 3.8e-16 59.4 0.0 2.0 2 0 0 2 2 2 1 Adaptin C-terminal domain GAT PF03127.9 KOH01180.1 - 6.6e-13 48.4 2.0 6.6e-13 48.4 1.4 2.9 3 0 0 3 3 3 1 GAT domain PrkA PF06798.7 KOH01180.1 - 0.0045 16.2 0.7 1.9 7.7 0.0 2.3 2 0 0 2 2 2 2 PrkA serine protein kinase C-terminal domain HSA PF07529.8 KOH01181.1 - 6e-18 64.3 0.1 6e-18 64.3 0.1 3.1 3 0 0 3 3 3 1 HSA Myb_DNA-bind_6 PF13921.1 KOH01181.1 - 1.9e-09 37.4 0.6 7.9e-09 35.4 0.4 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain BCIP PF13862.1 KOH01182.1 - 5.5e-51 172.8 0.5 7.7e-51 172.3 0.4 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein Imm7 PF15588.1 KOH01182.1 - 0.033 14.2 0.1 0.082 12.9 0.1 1.7 1 0 0 1 1 1 0 Immunity protein 7 YL1 PF05764.8 KOH01183.1 - 0.047 13.2 11.9 0.073 12.6 8.3 1.2 1 0 0 1 1 1 0 YL1 nuclear protein AT_hook PF02178.14 KOH01183.1 - 3.2 7.7 9.6 0.06 13.0 1.4 2.3 2 0 0 2 2 2 0 AT hook motif Rad60-SLD PF11976.3 KOH01184.1 - 2.1e-24 84.9 2.3 3e-23 81.3 1.2 2.7 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like FctA PF12892.2 KOH01184.1 - 0.041 14.6 2.1 0.041 14.6 1.5 2.7 3 0 0 3 3 3 0 T surface-antigen of pili DUF1509 PF07420.6 KOH01184.1 - 5.9 6.0 12.3 9.7 5.3 8.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) Peptidase_S49_N PF08496.5 KOH01184.1 - 6.6 6.5 17.4 3.2 7.5 1.3 2.7 2 1 0 2 2 2 0 Peptidase family S49 N-terminal DSS1_SEM1 PF05160.8 KOH01185.1 - 9e-22 76.6 14.4 1.4e-21 76.0 10.0 1.3 1 0 0 1 1 1 1 DSS1/SEM1 family Cwf_Cwc_15 PF04889.7 KOH01185.1 - 0.074 12.7 10.0 0.084 12.5 6.9 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein WD40 PF00400.27 KOH01186.1 - 1.5e-35 119.7 11.8 1.1e-09 37.7 0.0 6.3 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 KOH01186.1 - 0.026 12.6 0.0 0.051 11.6 0.0 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 NUC153 PF08159.7 KOH01187.1 - 1.1e-15 56.9 8.7 4.5e-15 54.9 0.6 3.1 3 0 0 3 3 3 2 NUC153 domain Kei1 PF08552.6 KOH01188.1 - 1.6e-60 204.0 8.7 1.8e-60 203.8 6.0 1.0 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 FHA PF00498.21 KOH01189.1 - 6.8e-06 26.1 0.2 2.7e-05 24.2 0.1 2.1 1 0 0 1 1 1 1 FHA domain RAI1 PF08652.6 KOH01190.1 - 2.9e-06 26.9 0.0 8e-06 25.5 0.0 1.8 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Glyco_hydro_18 PF00704.23 KOH01191.1 - 2e-83 280.7 6.3 2.5e-83 280.3 4.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GPP34 PF05719.6 KOH01192.1 - 2.3e-59 200.9 0.0 2.8e-59 200.6 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) EF-hand_1 PF00036.27 KOH01193.1 - 3.7e-27 91.5 6.3 1.3e-07 30.3 0.3 4.5 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOH01193.1 - 1.6e-25 86.6 1.9 2.2e-06 27.0 0.1 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOH01193.1 - 5.9e-22 77.5 6.5 7.6e-15 54.8 0.3 3.2 1 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOH01193.1 - 2.2e-18 65.5 8.1 1.9e-08 33.7 0.1 3.6 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOH01193.1 - 4.6e-17 60.4 6.3 1.1e-05 24.5 0.2 4.6 5 0 0 5 5 5 3 EF hand EF-hand_4 PF12763.2 KOH01193.1 - 0.00012 21.7 4.2 1.3 8.7 0.0 3.5 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOH01193.1 - 0.00029 20.8 0.8 0.011 15.7 0.2 2.9 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOH01193.1 - 0.00052 19.8 0.4 0.045 13.6 0.0 2.7 2 1 1 3 3 3 1 EF-hand domain S10_plectin PF03501.10 KOH01193.1 - 0.0028 17.4 0.0 0.0047 16.7 0.0 1.5 1 0 0 1 1 1 1 Plectin/S10 domain EF-hand_10 PF14788.1 KOH01193.1 - 0.028 14.0 0.2 4.4 7.0 0.0 3.0 3 0 0 3 3 3 0 EF hand YTH PF04146.10 KOH01194.1 - 4.9e-42 142.8 0.8 1.2e-41 141.5 0.6 1.7 1 0 0 1 1 1 1 YT521-B-like domain EVE PF01878.13 KOH01194.1 - 0.024 14.6 0.0 0.047 13.7 0.0 1.5 1 0 0 1 1 1 0 EVE domain BCS1_N PF08740.6 KOH01196.1 - 3.5e-50 170.2 0.0 5.8e-50 169.5 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 KOH01196.1 - 1.2e-23 83.7 0.0 2e-23 83.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOH01196.1 - 6.9e-06 26.8 0.0 1.5e-05 25.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOH01196.1 - 0.00051 20.3 0.0 0.0026 18.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOH01196.1 - 0.0006 19.6 0.0 0.0016 18.2 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_21 PF13304.1 KOH01196.1 - 0.00062 19.8 0.1 0.001 19.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOH01196.1 - 0.0014 17.7 0.0 0.0025 16.9 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOH01196.1 - 0.0017 18.4 0.0 0.0056 16.8 0.0 1.9 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.8 KOH01196.1 - 0.002 17.1 0.0 0.0031 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.1 KOH01196.1 - 0.0023 17.9 0.0 0.0046 16.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 KOH01196.1 - 0.0034 17.1 0.0 0.011 15.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 KOH01196.1 - 0.0045 16.8 0.0 0.0082 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 KOH01196.1 - 0.006 15.9 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOH01196.1 - 0.0071 15.4 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin ABC_tran PF00005.22 KOH01196.1 - 0.011 16.0 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.1 KOH01196.1 - 0.013 14.9 0.0 0.06 12.8 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain TIP49 PF06068.8 KOH01196.1 - 0.021 13.5 0.0 1.1 7.8 0.0 2.2 2 0 0 2 2 2 0 TIP49 C-terminus AAA_24 PF13479.1 KOH01196.1 - 0.023 14.2 0.1 0.049 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOH01196.1 - 0.023 14.8 0.0 0.072 13.2 0.0 1.9 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.7 KOH01196.1 - 0.03 13.9 0.0 0.26 10.9 0.0 2.5 2 1 1 3 3 3 0 NACHT domain Arch_ATPase PF01637.13 KOH01196.1 - 0.034 13.8 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase KaiC PF06745.8 KOH01196.1 - 0.035 13.2 0.0 0.071 12.2 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_19 PF13245.1 KOH01196.1 - 0.036 13.8 0.0 0.088 12.5 0.0 1.7 1 1 0 1 1 1 0 Part of AAA domain Miro PF08477.8 KOH01196.1 - 0.054 13.9 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein AAA_23 PF13476.1 KOH01196.1 - 0.072 13.4 0.0 0.17 12.1 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_11 PF13086.1 KOH01196.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KOH01196.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF3315 PF11776.3 KOH01196.1 - 0.34 10.4 0.0 0.34 10.4 0.0 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF3315) Pyr_redox_3 PF13738.1 KOH01197.1 - 1.7e-05 25.0 0.0 0.05 13.6 0.0 2.5 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KOH01197.1 - 8.7e-05 22.4 0.0 0.00018 21.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 KOH01197.1 - 0.0011 18.8 0.0 0.0047 16.7 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding Shikimate_DH PF01488.15 KOH01197.1 - 0.026 14.6 0.0 8.7 6.4 0.0 2.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.9 KOH01197.1 - 0.028 14.2 0.0 0.3 10.9 0.0 2.1 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOH01197.1 - 0.036 12.9 0.0 0.073 11.9 0.0 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.1 KOH01197.1 - 0.097 12.9 0.0 6.3 7.1 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding F1F0-ATPsyn_F PF10791.4 KOH01198.1 - 2.1e-42 143.2 0.2 2.3e-42 143.1 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.4 KOH01198.1 - 0.0017 18.4 0.1 0.0026 17.7 0.1 1.4 1 1 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f RhoGAP PF00620.22 KOH01199.1 - 1.1e-45 154.9 0.4 2.5e-45 153.8 0.3 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.17 KOH01199.1 - 1.3e-14 53.9 31.8 1.2e-09 38.1 5.8 2.6 2 0 0 2 2 2 2 LIM domain TMF_TATA_bd PF12325.3 KOH01199.1 - 0.00067 19.3 7.5 0.0015 18.2 4.0 2.5 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding Complex1_LYR PF05347.10 KOH01200.1 - 3.7e-11 42.6 0.1 4.6e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 KOH01200.1 - 7.2e-09 35.7 0.0 8.2e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Topoisom_I_N PF02919.10 KOH01200.1 - 0.055 12.7 0.0 0.061 12.6 0.0 1.0 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment TPP_enzyme_N PF02776.13 KOH01201.1 - 1.5e-27 96.1 0.0 2.3e-27 95.5 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 KOH01201.1 - 1.6e-18 66.7 0.0 2.9e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 KOH01201.1 - 1e-14 54.3 0.0 2.1e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Ribosomal_60s PF00428.14 KOH01202.1 - 8.5e-24 83.7 14.7 1e-23 83.5 10.2 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein TrmB PF01978.14 KOH01202.1 - 0.022 14.4 0.1 0.044 13.4 0.0 1.5 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Shadoo PF14999.1 KOH01202.1 - 0.76 9.6 7.6 1.4 8.7 5.3 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective Bacteriocin_IIc PF10439.4 KOH01202.1 - 1.1 9.4 7.7 1.5 9.0 3.7 1.9 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Grp1_Fun34_YaaH PF01184.14 KOH01204.1 - 3.4e-63 212.7 12.8 4.3e-63 212.4 8.9 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family GTP_EFTU PF00009.22 KOH01205.1 - 3.4e-63 212.4 0.2 4.9e-63 211.9 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 KOH01205.1 - 1.7e-36 124.4 0.1 6.8e-36 122.4 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.19 KOH01205.1 - 3e-21 75.0 0.0 7.9e-21 73.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 KOH01205.1 - 1.2e-13 50.7 0.0 3.8e-13 49.0 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 KOH01205.1 - 4.4e-12 45.9 0.0 4.4e-12 45.9 0.0 2.9 5 0 0 5 5 5 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KOH01205.1 - 9.4e-06 25.5 0.2 1.9e-05 24.6 0.2 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 KOH01205.1 - 0.067 12.6 0.8 0.3 10.5 0.4 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ERCC4 PF02732.10 KOH01206.1 - 4e-24 85.0 0.4 8.4e-24 83.9 0.3 1.6 1 0 0 1 1 1 1 ERCC4 domain HHH_3 PF12836.2 KOH01206.1 - 0.009 15.9 0.3 0.033 14.1 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif Sugar_tr PF00083.19 KOH01207.1 - 3.2e-92 309.4 28.7 7.8e-52 176.3 3.5 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 KOH01207.1 - 4.6e-23 81.4 33.4 7.7e-19 67.6 8.4 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2 PF04550.7 KOH01207.1 - 10 6.3 9.1 5.1 7.2 2.7 2.8 3 0 0 3 3 3 0 Phage holin family 2 BAR PF03114.13 KOH01208.1 - 5.1e-62 209.3 7.8 6.4e-62 209.0 5.4 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.23 KOH01208.1 - 1.5e-14 53.0 0.0 2.5e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOH01208.1 - 1e-12 47.4 0.1 1.7e-12 46.6 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOH01208.1 - 2.9e-08 33.0 0.0 5.5e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Vps5 PF09325.5 KOH01208.1 - 4.1 6.5 10.0 31 3.6 6.9 2.0 1 1 0 1 1 1 0 Vps5 C terminal like RhoGAP PF00620.22 KOH01209.1 - 8.4e-32 109.8 0.5 8.4e-31 106.6 0.4 2.3 1 1 0 1 1 1 1 RhoGAP domain DUF3408 PF11888.3 KOH01209.1 - 0.014 15.3 6.7 0.7 9.8 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3408) ThiF PF00899.16 KOH01210.1 - 1.1e-34 119.2 0.0 2e-34 118.3 0.0 1.5 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 KOH01210.1 - 9e-26 89.2 3.2 4e-25 87.1 0.8 2.9 4 0 0 4 4 4 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 KOH01210.1 - 4.4e-21 73.9 3.9 4.4e-21 73.9 2.7 1.8 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site UAE_UbL PF14732.1 KOH01210.1 - 0.0017 18.3 1.4 0.0037 17.3 0.3 2.1 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Shikimate_DH PF01488.15 KOH01210.1 - 0.0071 16.4 0.0 0.023 14.8 0.0 1.9 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 KOH01210.1 - 0.016 15.4 0.0 0.13 12.5 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding NotI PF12183.3 KOH01210.1 - 0.075 12.1 0.2 0.13 11.3 0.2 1.3 1 0 0 1 1 1 0 Restriction endonuclease NotI Aida_N PF08910.5 KOH01210.1 - 0.094 12.9 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Aida N-terminus Med30 PF11315.3 KOH01210.1 - 0.12 12.5 1.7 3.7 7.6 0.8 2.6 2 0 0 2 2 2 0 Mediator complex subunit 30 TFIID-18kDa PF02269.11 KOH01212.1 - 1.4e-37 127.4 0.4 5e-37 125.5 0.1 2.1 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Synaptobrevin PF00957.16 KOH01212.1 - 0.3 10.7 4.1 0.13 11.9 0.8 1.9 2 0 0 2 2 2 0 Synaptobrevin She9_MDM33 PF05546.6 KOH01213.1 - 2.7e-95 317.8 21.2 8.1e-95 316.2 9.1 2.1 2 0 0 2 2 2 2 She9 / Mdm33 family PsbH PF00737.15 KOH01213.1 - 0.068 12.7 0.5 0.14 11.7 0.4 1.4 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein DUF4482 PF14818.1 KOH01213.1 - 0.44 11.1 23.4 0.043 14.4 2.4 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF4482) DUF310 PF03750.8 KOH01213.1 - 1.8 8.7 9.0 1.9 8.6 0.1 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF310) OmpH PF03938.9 KOH01213.1 - 6.2 6.7 20.0 1.5e+03 -1.0 13.8 2.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Seryl_tRNA_N PF02403.17 KOH01213.1 - 6.8 6.7 24.2 5.3 7.1 9.1 3.0 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain COG2 PF06148.6 KOH01213.1 - 7.7 6.3 12.7 4.7 7.0 0.1 3.5 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 AAA PF00004.24 KOH01214.1 - 1.7e-46 157.6 0.3 7.6e-46 155.5 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 KOH01214.1 - 2.8e-08 33.8 0.0 7.3e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 KOH01214.1 - 9.1e-08 31.9 0.1 4.3e-07 29.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOH01214.1 - 4.9e-07 29.9 0.1 1.7e-06 28.1 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 KOH01214.1 - 2.7e-06 27.5 2.0 9.2e-05 22.5 0.3 2.8 2 1 0 2 2 1 1 AAA domain DUF815 PF05673.8 KOH01214.1 - 0.0001 21.3 0.0 0.00018 20.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.1 KOH01214.1 - 0.00017 21.5 0.0 0.00054 19.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.10 KOH01214.1 - 0.0004 20.1 0.0 0.0011 18.7 0.0 1.8 1 0 0 1 1 1 1 NTPase RuvB_N PF05496.7 KOH01214.1 - 0.0005 19.1 0.0 0.0012 17.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 KOH01214.1 - 0.0005 20.8 0.0 0.0022 18.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 KOH01214.1 - 0.00094 18.8 0.1 0.0085 15.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 KOH01214.1 - 0.0014 18.2 0.0 0.0034 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOH01214.1 - 0.0015 18.2 0.1 0.0037 16.9 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 KOH01214.1 - 0.0018 17.3 0.0 0.0039 16.3 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin RNA_helicase PF00910.17 KOH01214.1 - 0.0019 18.3 0.0 0.0039 17.3 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.1 KOH01214.1 - 0.0023 17.8 0.0 0.006 16.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 KOH01214.1 - 0.0028 17.3 0.2 0.044 13.4 0.0 2.5 1 1 0 2 2 2 1 NACHT domain AAA_30 PF13604.1 KOH01214.1 - 0.0029 17.2 0.0 0.0066 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 KOH01214.1 - 0.0036 16.7 0.0 0.14 11.5 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_3 PF07726.6 KOH01214.1 - 0.0036 16.8 0.0 0.0098 15.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 KOH01214.1 - 0.0039 16.6 1.0 0.13 11.6 0.1 2.5 1 1 0 2 2 2 1 AAA domain TIP49 PF06068.8 KOH01214.1 - 0.0044 15.8 0.0 0.0071 15.1 0.0 1.4 1 1 0 1 1 1 1 TIP49 C-terminus AAA_28 PF13521.1 KOH01214.1 - 0.0049 16.8 0.1 0.012 15.5 0.0 1.7 2 0 0 2 2 1 1 AAA domain UPF0079 PF02367.12 KOH01214.1 - 0.0058 16.2 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 Mg_chelatase PF01078.16 KOH01214.1 - 0.0059 15.7 0.1 0.016 14.4 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 KOH01214.1 - 0.0065 16.7 0.0 0.045 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 KOH01214.1 - 0.0077 15.9 0.7 0.094 12.3 0.0 2.6 2 1 1 3 3 3 1 Archaeal ATPase IstB_IS21 PF01695.12 KOH01214.1 - 0.013 14.9 0.0 0.032 13.6 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_23 PF13476.1 KOH01214.1 - 0.044 14.1 5.5 3.4 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 KOH01214.1 - 0.058 12.2 0.4 0.2 10.5 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain ABC_tran PF00005.22 KOH01214.1 - 0.1 12.8 0.2 0.34 11.1 0.0 2.2 2 1 0 2 2 2 0 ABC transporter IBN_N PF03810.14 KOH01215.1 - 3.5e-20 71.6 0.3 1.1e-19 70.0 0.2 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain CBFD_NFYB_HMF PF00808.18 KOH01216.1 - 6.2e-09 35.7 0.7 9e-09 35.2 0.5 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Utp12 PF04003.7 KOH01217.1 - 1.7e-22 79.4 0.4 3e-22 78.5 0.3 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family C2 PF00168.25 KOH01217.1 - 0.029 14.1 0.0 0.094 12.5 0.0 1.8 1 0 0 1 1 1 0 C2 domain BBS2_Mid PF14783.1 KOH01217.1 - 0.034 13.9 0.3 28 4.5 0.0 3.5 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Pribosyltran PF00156.22 KOH01218.1 - 1.9e-11 43.7 0.0 3.8e-11 42.7 0.0 1.5 1 1 0 1 1 1 1 Phosphoribosyl transferase domain 3Beta_HSD PF01073.14 KOH01218.1 - 0.069 11.8 0.0 0.087 11.5 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Fe-ADH PF00465.14 KOH01218.1 - 0.1 11.2 0.0 0.17 10.4 0.0 1.3 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase Mito_fiss_Elm1 PF06258.6 KOH01218.1 - 0.11 11.3 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial fission ELM1 IU_nuc_hydro PF01156.14 KOH01219.1 - 2.2e-77 260.3 0.0 2.5e-77 260.1 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase p450 PF00067.17 KOH01220.1 - 6.8e-55 186.4 0.0 8.7e-55 186.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DIT1_PvcA PF05141.7 KOH01221.1 - 2.8e-107 358.2 0.0 3.6e-107 357.8 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein BssC_TutF PF08201.6 KOH01221.1 - 0.021 14.3 0.3 0.058 12.8 0.2 1.7 1 0 0 1 1 1 0 BssC/TutF protein SHS2_Rpb7-N PF03876.12 KOH01222.1 - 2.1e-16 59.8 0.0 4e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 KOH01222.1 - 1.3e-15 57.2 0.1 1.8e-15 56.7 0.1 1.2 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.7 KOH01222.1 - 2.2e-06 27.8 0.0 4.3e-06 26.9 0.0 1.4 1 1 1 2 2 2 1 RNA polymerase III subunit Rpc25 Ribosomal_L23 PF00276.15 KOH01223.1 - 5e-27 93.6 0.0 7.9e-27 93.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L23 TRAPPC9-Trs120 PF08626.6 KOH01225.1 - 0 1300.1 43.7 0 1299.4 30.3 1.3 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit PINIT PF14324.1 KOH01226.1 - 2.9e-37 127.9 0.0 9.5e-37 126.2 0.0 2.0 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.15 KOH01226.1 - 8.2e-21 73.2 6.5 1.4e-20 72.5 4.5 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.22 KOH01226.1 - 7.2e-09 34.9 0.0 1.6e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 SAP domain zf-Nse PF11789.3 KOH01226.1 - 0.00053 19.4 1.1 0.0013 18.2 0.8 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KOH01226.1 - 0.51 10.0 3.1 1.6 8.5 2.1 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.1 KOH01226.1 - 1.7 8.7 3.8 3.2 7.8 2.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) ICMT PF04140.9 KOH01227.1 - 7.2e-31 106.2 0.8 1.3e-30 105.4 0.6 1.4 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 KOH01227.1 - 2.6e-16 59.6 1.0 5.3e-16 58.6 0.7 1.5 1 0 0 1 1 1 1 Phospholipid methyltransferase DUF1295 PF06966.7 KOH01227.1 - 6.4e-07 28.9 0.4 7.7e-07 28.6 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.6 KOH01227.1 - 0.0014 17.9 0.8 0.0019 17.6 0.5 1.3 1 0 0 1 1 1 1 NnrU protein DER1 PF04511.10 KOH01228.1 - 1.9e-57 193.9 12.3 2.2e-57 193.7 8.5 1.0 1 0 0 1 1 1 1 Der1-like family Nop25 PF09805.4 KOH01229.1 - 4e-39 133.8 17.2 4e-39 133.8 11.9 2.0 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) RyR PF02026.11 KOH01229.1 - 5.9 6.9 7.6 0.32 11.0 0.5 2.3 2 1 0 2 2 2 0 RyR domain EXS PF03124.9 KOH01230.1 - 1.1e-60 205.5 27.9 1.3e-60 205.3 19.4 1.0 1 0 0 1 1 1 1 EXS family Peptidase_M28 PF04389.12 KOH01231.1 - 3.5e-26 92.0 0.0 5.9e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 KOH01231.1 - 6.9e-05 22.4 0.0 9.5e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DUF1849 PF08904.6 KOH01231.1 - 0.014 14.7 0.1 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1849) TPR_14 PF13428.1 KOH01232.1 - 1.8e-06 28.0 0.3 0.42 11.3 0.0 4.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOH01232.1 - 0.0044 16.9 0.0 1.2 9.1 0.0 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOH01232.1 - 0.026 14.4 0.7 36 4.5 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_L11_N PF03946.9 KOH01233.1 - 4.3e-17 61.3 0.2 8.6e-17 60.3 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 KOH01233.1 - 3.3e-11 43.1 0.8 6.7e-11 42.1 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain IMS PF00817.15 KOH01234.1 - 2.1e-47 160.6 0.0 4.3e-47 159.6 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 KOH01234.1 - 3e-13 49.8 0.1 1.5e-12 47.5 0.0 2.0 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain zf-C2H2_6 PF13912.1 KOH01234.1 - 0.00054 19.7 0.6 0.0011 18.7 0.4 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger IMS_HHH PF11798.3 KOH01234.1 - 0.0017 18.2 0.0 0.0037 17.2 0.0 1.6 1 0 0 1 1 1 1 IMS family HHH motif DUF1805 PF08827.6 KOH01234.1 - 0.025 14.3 0.0 0.082 12.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1805) Zn_clus PF00172.13 KOH01236.1 - 4e-07 29.8 8.5 9.7e-07 28.6 5.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MULE PF10551.4 KOH01236.1 - 0.04 14.0 0.0 0.13 12.4 0.0 1.9 1 0 0 1 1 1 0 MULE transposase domain AMPKBI PF04739.10 KOH01237.1 - 1.8e-27 95.1 0.0 1.8e-27 95.1 0.0 3.2 3 1 0 3 3 3 1 5'-AMP-activated protein kinase beta subunit, interation domain PX PF00787.19 KOH01238.1 - 5.3e-18 64.8 0.3 4.3e-17 61.9 0.0 2.6 2 1 0 2 2 2 1 PX domain RP-C_C PF11800.3 KOH01238.1 - 0.54 9.9 4.1 1.4 8.5 2.9 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4206 PF13901.1 KOH01238.1 - 6.3 6.2 11.2 0.38 10.2 1.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4206) PCI PF01399.22 KOH01239.1 - 1.4e-13 51.0 0.3 1.4e-13 51.0 0.2 2.4 3 1 0 3 3 3 1 PCI domain Foie-gras_1 PF11817.3 KOH01239.1 - 0.093 12.1 0.1 0.16 11.4 0.1 1.3 1 0 0 1 1 1 0 Foie gras liver health family 1 DUF4298 PF14131.1 KOH01239.1 - 2.8 7.8 7.5 5.5 6.9 0.0 4.2 4 1 0 4 4 4 0 Domain of unknown function (DUF4298) Abhydrolase_3 PF07859.8 KOH01240.1 - 1.5e-07 31.2 0.0 1.7e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 KOH01240.1 - 1.4e-05 23.9 0.0 2e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 KOH01240.1 - 3.5e-05 23.5 0.0 5.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOH01240.1 - 0.00023 21.1 0.0 0.00063 19.6 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOH01240.1 - 0.014 14.9 0.0 0.032 13.7 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2305 PF10230.4 KOH01240.1 - 0.026 13.9 0.0 0.048 13.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) DUF900 PF05990.7 KOH01240.1 - 0.11 11.7 0.2 0.21 10.8 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) eIF3g PF12353.3 KOH01241.1 - 8.8e-42 142.0 0.5 1.3e-41 141.4 0.3 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.17 KOH01241.1 - 5.1e-11 42.0 0.0 8e-11 41.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOH01241.1 - 3.7e-09 36.4 0.0 6.5e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOH01241.1 - 2.4e-06 27.3 0.0 4.4e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) M16C_assoc PF08367.6 KOH01242.1 - 1e-81 273.4 0.4 1.7e-81 272.7 0.3 1.4 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.16 KOH01242.1 - 1.9e-35 122.1 0.2 1.3e-16 60.8 0.0 3.1 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 KOH01242.1 - 1.6e-05 24.6 0.0 4.6e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Glucodextran_N PF09137.6 KOH01242.1 - 0.046 12.9 0.0 0.23 10.6 0.0 1.9 2 0 0 2 2 2 0 Glucodextranase, domain N RRM_1 PF00076.17 KOH01243.1 - 1.3e-29 101.5 0.2 1.7e-17 62.8 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOH01243.1 - 4.2e-16 58.6 0.0 7.1e-11 41.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOH01243.1 - 1.2e-09 37.8 0.0 5.6e-09 35.7 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.6 KOH01243.1 - 0.046 13.6 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 RNA binding domain PIG-S PF10510.4 KOH01244.1 - 5.6e-144 480.6 5.0 6.4e-144 480.4 3.5 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein LCM PF04072.9 KOH01245.1 - 7.7e-27 94.0 0.0 9.9e-27 93.6 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Metallophos PF00149.23 KOH01246.1 - 3.5e-38 131.0 0.2 5.3e-38 130.4 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PIG-P PF08510.7 KOH01247.1 - 1.8e-32 111.6 2.3 2.1e-32 111.4 1.6 1.0 1 0 0 1 1 1 1 PIG-P DUF4131 PF13567.1 KOH01247.1 - 0.11 11.9 0.1 0.14 11.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) EamA PF00892.15 KOH01248.1 - 6.1e-07 29.5 40.7 7.9e-07 29.1 5.6 3.5 3 1 1 4 4 4 2 EamA-like transporter family EmrE PF13536.1 KOH01248.1 - 3.8e-05 23.8 1.1 3.8e-05 23.8 0.7 2.8 3 0 0 3 3 3 2 Multidrug resistance efflux transporter TPT PF03151.11 KOH01248.1 - 0.00015 21.4 30.2 0.0016 18.0 2.3 2.7 3 0 0 3 3 3 2 Triose-phosphate Transporter family UAA PF08449.6 KOH01248.1 - 0.0015 17.5 23.0 0.0032 16.4 15.9 1.6 1 1 0 1 1 1 1 UAA transporter family FA_desaturase PF00487.19 KOH01248.1 - 2.3 7.6 10.3 0.98 8.7 2.8 2.9 2 2 1 3 3 3 0 Fatty acid desaturase LRS4 PF10422.4 KOH01249.1 - 2.1e-56 191.0 24.6 2.1e-56 191.0 17.0 2.0 2 0 0 2 2 2 1 Monopolin complex subunit LRS4 DUF1003 PF06210.6 KOH01249.1 - 1.4 8.8 5.8 0.41 10.5 0.6 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1003) DOT1 PF08123.8 KOH01250.1 - 4.8e-92 306.8 0.6 1e-91 305.8 0.4 1.6 1 0 0 1 1 1 1 Histone methylation protein DOT1 CMAS PF02353.15 KOH01250.1 - 0.028 13.5 0.0 0.075 12.1 0.0 1.7 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Pribosyltran PF00156.22 KOH01251.1 - 3.8e-18 65.4 0.0 5.6e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 KOH01251.1 - 0.00042 19.5 0.0 0.00057 19.1 0.0 1.5 1 1 0 1 1 1 1 Uracil phosphoribosyltransferase Med13_C PF06333.7 KOH01252.1 - 3.2e-91 305.9 17.5 1.4e-90 303.8 4.2 3.3 2 1 0 2 2 2 1 Mediator complex subunit 13 C-terminal DUF676 PF05057.9 KOH01253.1 - 9.3e-61 204.8 0.0 1.5e-60 204.2 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.20 KOH01253.1 - 1.2e-05 24.8 0.0 3.4e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 Lipase (class 3) DUF915 PF06028.6 KOH01253.1 - 0.0015 17.6 0.0 0.0029 16.7 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) ECM11 PF15463.1 KOH01254.1 - 8.3e-27 94.1 0.9 8.3e-27 94.1 0.7 2.5 2 1 1 3 3 3 1 Extracellular mutant protein 11 UPF0449 PF15136.1 KOH01254.1 - 0.095 12.9 1.2 0.6 10.3 0.2 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Ribosomal_S17e PF00833.13 KOH01255.1 - 2.4e-41 140.3 0.1 2.8e-41 140.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal S17 Cryptochrome_C PF12546.3 KOH01255.1 - 0.11 13.1 0.0 0.14 12.8 0.0 1.2 1 0 0 1 1 1 0 Blue/Ultraviolet sensing protein C terminal ZZ PF00569.12 KOH01256.1 - 1.3e-17 63.0 8.4 2.4e-17 62.2 5.8 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type SWIRM PF04433.12 KOH01256.1 - 2.3e-11 43.6 0.1 2.5e-09 37.1 0.0 2.7 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-binding PF00249.26 KOH01256.1 - 1.4e-09 37.8 0.4 2.9e-09 36.8 0.1 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOH01256.1 - 0.0001 22.2 1.8 0.00026 21.0 0.0 2.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain U3_assoc_6 PF08640.6 KOH01257.1 - 3.7e-34 116.3 6.7 3.3e-33 113.2 0.4 3.2 2 1 1 3 3 3 2 U3 small nucleolar RNA-associated protein 6 NRDE-2 PF08424.5 KOH01257.1 - 1.1e-06 27.7 4.3 0.0004 19.3 0.6 2.4 1 1 1 2 2 2 2 NRDE-2, necessary for RNA interference Suf PF05843.9 KOH01257.1 - 0.0043 16.8 10.7 0.022 14.4 3.9 4.0 3 1 0 3 3 3 1 Suppressor of forked protein (Suf) DUF2250 PF10007.4 KOH01257.1 - 0.015 15.1 4.1 0.24 11.3 0.0 3.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2250) TPR_17 PF13431.1 KOH01257.1 - 0.028 14.6 1.3 9.6 6.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOH01257.1 - 0.056 14.1 0.0 2.1 9.2 0.0 2.6 1 1 0 2 2 2 0 Tetratricopeptide repeat HAT PF02184.11 KOH01257.1 - 0.11 12.3 0.3 0.53 10.0 0.0 2.2 2 0 0 2 2 2 0 HAT (Half-A-TPR) repeat Ribosomal_S13 PF00416.17 KOH01258.1 - 1.5e-42 144.4 2.0 1.7e-42 144.1 1.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 KOH01258.1 - 0.0011 17.5 0.1 0.0015 17.1 0.0 1.2 1 1 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF3007 PF11460.3 KOH01258.1 - 0.097 12.7 0.2 0.2 11.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) Homeobox PF00046.24 KOH01259.1 - 1.4e-18 66.1 2.1 3.1e-18 65.1 1.5 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 KOH01259.1 - 0.00028 20.5 0.4 0.0018 17.9 0.1 2.3 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.3 KOH01259.1 - 0.19 10.8 0.7 0.39 9.8 0.5 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Metallophos PF00149.23 KOH01260.1 - 4.3e-14 52.3 0.8 8.3e-14 51.4 0.6 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase AhpC-TSA PF00578.16 KOH01261.1 - 1.9e-35 121.2 0.0 1.6e-34 118.2 0.0 1.9 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 KOH01261.1 - 5.7e-19 68.1 0.0 9.7e-19 67.3 0.0 1.3 2 0 0 2 2 2 1 Redoxin 1-cysPrx_C PF10417.4 KOH01261.1 - 1.4e-10 40.5 0.2 2.9e-10 39.6 0.2 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Guanylate_kin PF00625.16 KOH01262.1 - 4e-69 231.7 0.0 4.4e-69 231.5 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase MMR_HSR1 PF01926.18 KOH01262.1 - 5.4e-06 26.3 0.1 1.2e-05 25.2 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 KOH01262.1 - 6.4e-06 26.2 0.0 3.4e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.1 KOH01262.1 - 7.2e-06 25.9 0.0 1.7e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOH01262.1 - 9.2e-06 26.4 0.1 1.9e-05 25.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOH01262.1 - 1.4e-05 25.2 0.1 8.4e-05 22.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KOH01262.1 - 2.8e-05 24.4 0.5 0.00027 21.2 0.2 2.2 1 1 0 1 1 1 1 AAA domain Miro PF08477.8 KOH01262.1 - 6.2e-05 23.4 0.0 0.00019 21.9 0.0 1.7 1 1 0 2 2 1 1 Miro-like protein AAA_14 PF13173.1 KOH01262.1 - 0.00051 19.9 0.0 0.0011 18.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOH01262.1 - 0.00081 19.3 0.0 0.0019 18.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 KOH01262.1 - 0.00087 19.6 0.1 0.0011 19.2 0.1 1.5 1 1 0 1 1 1 1 ABC transporter DUF258 PF03193.11 KOH01262.1 - 0.0014 17.8 0.0 0.0022 17.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_19 PF13245.1 KOH01262.1 - 0.002 17.8 0.0 0.0074 16.0 0.0 2.0 2 0 0 2 2 2 1 Part of AAA domain RNA_helicase PF00910.17 KOH01262.1 - 0.0026 17.9 0.0 0.0064 16.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase NACHT PF05729.7 KOH01262.1 - 0.0032 17.1 0.0 0.0059 16.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA PF00004.24 KOH01262.1 - 0.0042 17.2 0.4 0.012 15.7 0.3 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.1 KOH01262.1 - 0.0053 16.3 0.5 0.11 12.0 0.2 2.1 1 1 0 2 2 2 1 AAA domain T2SE PF00437.15 KOH01262.1 - 0.0069 15.3 0.0 0.014 14.3 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein NTPase_1 PF03266.10 KOH01262.1 - 0.0073 16.0 0.1 0.0096 15.6 0.1 1.4 1 1 0 1 1 1 1 NTPase DUF2075 PF09848.4 KOH01262.1 - 0.0073 15.3 0.0 0.033 13.1 0.0 1.8 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2075) Arch_ATPase PF01637.13 KOH01262.1 - 0.0082 15.8 0.1 0.015 15.0 0.0 1.6 1 1 0 1 1 1 1 Archaeal ATPase SRPRB PF09439.5 KOH01262.1 - 0.0089 15.2 0.0 0.017 14.3 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_10 PF12846.2 KOH01262.1 - 0.0092 15.4 0.1 0.018 14.5 0.1 1.4 1 0 0 1 1 1 1 AAA-like domain AAA_29 PF13555.1 KOH01262.1 - 0.0095 15.4 1.8 0.018 14.5 0.1 2.1 2 1 0 2 2 2 1 P-loop containing region of AAA domain MobB PF03205.9 KOH01262.1 - 0.015 14.9 1.1 0.16 11.7 0.1 2.5 1 1 1 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 KOH01262.1 - 0.023 14.3 0.0 0.044 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 KOH01262.1 - 0.025 14.1 0.0 0.071 12.6 0.0 1.7 1 1 1 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.1 KOH01262.1 - 0.029 14.6 3.1 0.08 13.2 2.1 2.0 1 1 0 1 1 1 0 AAA domain KAP_NTPase PF07693.9 KOH01262.1 - 0.037 12.9 0.0 0.062 12.2 0.0 1.3 1 1 0 1 1 1 0 KAP family P-loop domain AAA_25 PF13481.1 KOH01262.1 - 0.051 12.9 0.1 0.2 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.13 KOH01262.1 - 0.052 12.8 0.3 5.5 6.2 0.0 2.1 1 1 1 2 2 2 0 Ferrous iron transport protein B Rad17 PF03215.10 KOH01262.1 - 0.061 12.0 0.0 0.079 11.6 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein cobW PF02492.14 KOH01262.1 - 0.065 12.6 0.0 0.26 10.7 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.9 KOH01262.1 - 0.1 12.3 0.1 0.36 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Na_H_Exchanger PF00999.16 KOH01263.1 - 2.7e-67 226.9 35.7 3.5e-67 226.5 24.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Myc_target_1 PF15179.1 KOH01263.1 - 0.067 12.7 4.2 0.16 11.5 1.1 2.5 2 0 0 2 2 2 0 Myc target protein 1 HECT PF00632.20 KOH01264.1 - 7.9e-90 301.2 0.6 4.2e-89 298.8 0.0 2.6 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.7 KOH01264.1 - 1.5e-77 261.1 2.9 1.5e-77 261.1 2.0 2.5 2 0 0 2 2 2 1 Domain of Unknown Function (DUF908) DUF913 PF06025.7 KOH01264.1 - 4.2e-46 157.4 0.1 1.6e-45 155.5 0.0 2.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) DUF4414 PF14377.1 KOH01264.1 - 8.4e-15 54.6 0.7 2.4e-14 53.1 0.5 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4414) MSC PF09402.5 KOH01265.1 - 9.2e-92 307.2 6.2 9.2e-92 307.2 4.3 1.8 2 0 0 2 2 2 1 Man1-Src1p-C-terminal domain HeH PF12949.2 KOH01265.1 - 2.3e-16 59.0 3.7 7.1e-16 57.4 0.1 2.5 2 0 0 2 2 2 1 HeH/LEM domain zf-DHHC PF01529.15 KOH01266.1 - 1.4e-28 99.4 1.8 1.4e-28 99.4 1.2 2.3 2 1 1 3 3 3 1 DHHC palmitoyltransferase UbiA PF01040.13 KOH01266.1 - 6.5 5.8 11.3 0.29 10.3 0.9 2.2 2 1 0 2 2 2 0 UbiA prenyltransferase family MAT1 PF06391.8 KOH01267.1 - 6.5e-69 231.5 28.4 8.3e-69 231.1 19.7 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_3 PF13920.1 KOH01267.1 - 0.0009 18.8 4.7 0.0016 18.0 3.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOH01267.1 - 0.0027 17.6 7.1 0.0083 16.1 5.0 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOH01267.1 - 0.005 16.4 5.0 0.023 14.3 3.5 2.0 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOH01267.1 - 0.0056 16.4 5.7 0.021 14.6 4.3 1.7 1 1 1 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 KOH01267.1 - 0.029 14.1 8.3 0.17 11.6 5.9 2.1 1 1 1 2 2 2 0 zinc-RING finger domain FlpD PF02662.11 KOH01267.1 - 0.15 11.8 5.3 2.6 7.7 1.6 2.5 2 0 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit zf-piccolo PF05715.8 KOH01267.1 - 0.17 11.8 1.2 0.44 10.5 0.9 1.7 1 0 0 1 1 1 0 Piccolo Zn-finger GvpK PF05121.7 KOH01267.1 - 0.32 10.8 7.2 0.13 12.1 1.3 2.6 1 1 1 3 3 3 0 Gas vesicle protein K RasGEF_N PF00618.15 KOH01267.1 - 0.34 11.0 2.5 3 8.0 0.0 2.3 2 0 0 2 2 2 0 RasGEF N-terminal motif Exonuc_VII_L PF02601.10 KOH01267.1 - 0.47 9.5 9.5 0.7 9.0 6.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-RING_UBOX PF13445.1 KOH01267.1 - 0.8 9.4 6.0 0.58 9.9 2.6 2.1 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_4 PF14570.1 KOH01267.1 - 1 9.0 9.5 12 5.5 6.6 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain DUF948 PF06103.6 KOH01267.1 - 1.5 8.7 4.4 26 4.7 0.7 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Mitovir_RNA_pol PF05919.6 KOH01267.1 - 1.7 7.5 7.2 2.1 7.1 5.0 1.1 1 0 0 1 1 1 0 Mitovirus RNA-dependent RNA polymerase Tweety PF04906.8 KOH01267.1 - 2.2 6.6 4.4 0.68 8.2 0.3 1.9 1 1 1 2 2 2 0 Tweety DUF964 PF06133.6 KOH01267.1 - 8.2 6.4 16.4 25 4.9 8.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF964) MRP-L28 PF09812.4 KOH01269.1 - 5.6e-44 149.7 3.7 6.5e-44 149.5 2.6 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 zf-C2H2 PF00096.21 KOH01270.1 - 0.00077 19.6 2.0 0.00077 19.6 1.4 4.3 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOH01270.1 - 0.0022 18.2 1.0 0.0022 18.2 0.7 3.3 3 0 0 3 3 3 1 C2H2-type zinc finger Prp31_C PF09785.4 KOH01270.1 - 0.02 15.3 0.9 0.02 15.3 0.6 1.9 2 0 0 2 2 2 0 Prp31 C terminal domain zf-H2C2_2 PF13465.1 KOH01270.1 - 0.031 14.5 1.7 0.031 14.5 1.1 3.7 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_6 PF13912.1 KOH01270.1 - 0.17 11.8 3.0 4.8 7.2 0.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-BED PF02892.10 KOH01270.1 - 0.79 9.5 9.0 0.039 13.7 1.2 2.6 3 0 0 3 3 3 0 BED zinc finger DUF3020 PF11223.3 KOH01271.1 - 7.2e-13 48.7 35.1 9e-12 45.1 3.2 8.3 7 1 1 8 8 8 2 Protein of unknown function (DUF3020) Methyltransf_11 PF08241.7 KOH01272.1 - 0.058 13.8 0.0 0.17 12.4 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain PAS_4 PF08448.5 KOH01272.1 - 0.1 12.6 0.0 0.36 10.8 0.0 2.1 1 1 0 1 1 1 0 PAS fold Pkinase PF00069.20 KOH01273.1 - 9.3e-62 208.5 0.0 1.4e-61 207.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH01273.1 - 5e-29 101.1 0.0 8.8e-29 100.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH01273.1 - 5.8e-07 28.7 0.0 1.1e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOH01273.1 - 0.00056 19.7 0.2 0.0009 19.0 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family PIP49_C PF12260.3 KOH01273.1 - 0.017 14.5 0.1 0.044 13.1 0.1 1.6 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 SNARE PF05739.14 KOH01274.1 - 6.8e-15 54.5 4.0 6.8e-15 54.5 2.8 3.4 3 1 0 3 3 3 1 SNARE domain Syntaxin-6_N PF09177.6 KOH01274.1 - 6.5e-06 26.4 2.4 6.5e-06 26.4 1.7 2.2 2 0 0 2 2 2 1 Syntaxin 6, N-terminal Myosin_tail_1 PF01576.14 KOH01274.1 - 0.022 12.4 9.8 0.027 12.2 6.8 1.0 1 0 0 1 1 1 0 Myosin tail Nup88 PF10168.4 KOH01274.1 - 0.034 11.9 8.8 0.11 10.2 0.3 2.0 2 0 0 2 2 2 0 Nuclear pore component Sec20 PF03908.8 KOH01274.1 - 0.037 13.7 1.9 0.18 11.5 0.0 2.6 2 1 1 3 3 3 0 Sec20 RmuC PF02646.11 KOH01274.1 - 0.087 11.6 5.1 0.093 11.5 0.3 2.4 2 1 0 2 2 2 0 RmuC family DUF724 PF05266.9 KOH01274.1 - 0.24 11.0 7.6 0.087 12.4 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF4164 PF13747.1 KOH01274.1 - 0.34 11.0 6.9 1.8 8.7 1.1 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) CHASE3 PF05227.8 KOH01274.1 - 0.55 9.9 8.0 0.066 12.8 2.2 1.8 2 0 0 2 2 2 0 CHASE3 domain DUF972 PF06156.8 KOH01274.1 - 0.58 10.5 5.2 18 5.7 3.0 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Dpy-30 PF05186.8 KOH01275.1 - 1.6e-15 56.3 0.1 2.2e-15 55.8 0.1 1.2 1 0 0 1 1 1 1 Dpy-30 motif Mito_carr PF00153.22 KOH01276.1 - 8e-13 47.9 0.2 0.00021 20.9 0.0 4.1 4 0 0 4 4 4 3 Mitochondrial carrier protein NBP1 PF08537.5 KOH01276.1 - 0.1 11.7 0.2 0.18 10.9 0.1 1.3 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 Ribosomal_L27e PF01777.13 KOH01277.1 - 3.4e-36 123.2 6.9 4.5e-36 122.8 4.8 1.2 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.24 KOH01277.1 - 0.00025 20.6 1.5 0.0005 19.6 1.0 1.6 1 0 0 1 1 1 1 KOW motif DUF1512 PF07431.7 KOH01277.1 - 0.1 11.3 0.1 0.17 10.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) TRAPP PF04051.11 KOH01278.1 - 4.1e-51 172.4 0.0 7.2e-51 171.6 0.0 1.4 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component SSP160 PF06933.6 KOH01278.1 - 0.039 11.9 5.1 0.046 11.7 3.5 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PRP3 PF08572.5 KOH01279.1 - 7.9e-54 182.3 20.7 7.9e-54 182.3 11.8 2.2 1 1 1 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.7 KOH01279.1 - 2.7e-34 117.5 0.8 2.7e-34 117.5 0.6 2.7 4 0 0 4 4 4 1 Protein of unknown function (DUF1115) DUF3641 PF12345.3 KOH01279.1 - 0.043 13.6 0.2 0.12 12.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3641) Pkinase PF00069.20 KOH01282.1 - 4.8e-77 258.6 0.0 8.8e-77 257.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH01282.1 - 5.8e-38 130.4 0.0 9.7e-38 129.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.6 KOH01282.1 - 1e-22 80.0 1.3 1e-22 80.0 0.9 2.1 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.1 KOH01282.1 - 2.4e-10 39.8 0.0 6.3e-10 38.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 KOH01282.1 - 3.3e-05 23.3 0.7 8.7e-05 21.9 0.5 1.6 1 0 0 1 1 1 1 RIO1 family YukC PF10140.4 KOH01282.1 - 0.0001 21.0 0.2 0.00018 20.2 0.2 1.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC Kdo PF06293.9 KOH01282.1 - 0.0052 15.8 0.1 0.01 14.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOH01282.1 - 0.025 14.3 0.2 0.76 9.4 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Rpr2 PF04032.11 KOH01283.1 - 3.5e-12 46.0 2.5 3.5e-12 46.0 1.7 1.8 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-ribbon_3 PF13248.1 KOH01283.1 - 0.97 8.7 9.0 0.8 8.9 2.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 KOH01283.1 - 2.1 7.9 7.5 0.5 9.9 1.8 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Pex24p PF06398.6 KOH01284.1 - 1.3e-86 290.6 8.1 1.6e-86 290.3 5.6 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Alk_phosphatase PF00245.15 KOH01286.1 - 1.7e-150 501.3 0.0 2.1e-150 501.1 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.13 KOH01286.1 - 5.9e-05 22.5 0.0 0.00021 20.7 0.0 2.0 3 0 0 3 3 3 1 Metalloenzyme superfamily MFS_1 PF07690.11 KOH01286.1 - 0.044 12.4 0.0 0.065 11.9 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily cwf21 PF08312.7 KOH01287.1 - 9.1e-16 57.4 3.9 1.9e-15 56.4 2.7 1.6 1 0 0 1 1 1 1 cwf21 domain Trans_reg_C PF00486.23 KOH01287.1 - 0.091 12.6 0.2 0.74 9.7 0.1 2.1 1 1 1 2 2 2 0 Transcriptional regulatory protein, C terminal DUF4549 PF15082.1 KOH01287.1 - 0.094 12.3 2.6 0.84 9.2 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4549) Rota_NSP4 PF01452.11 KOH01287.1 - 0.11 11.7 2.7 0.15 11.4 1.8 1.1 1 0 0 1 1 1 0 Rotavirus non structural protein Glyco_transf_15 PF01793.11 KOH01288.1 - 1.4e-141 471.2 13.2 1.8e-141 470.9 9.1 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Vps52 PF04129.7 KOH01289.1 - 6.3e-192 638.6 27.8 7.7e-192 638.3 19.3 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family DUF3371 PF11851.3 KOH01289.1 - 0.56 10.8 3.8 0.28 11.8 0.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) YL1 PF05764.8 KOH01290.1 - 7.1e-61 205.8 45.6 7.1e-61 205.8 31.6 2.7 2 0 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.6 KOH01290.1 - 3.1e-14 52.1 0.5 5.7e-14 51.3 0.3 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Gly_transf_sug PF04488.10 KOH01290.1 - 0.11 12.8 1.3 0.86 10.0 0.0 3.0 3 1 0 3 3 3 0 Glycosyltransferase sugar-binding region containing DXD motif Snf7 PF03357.16 KOH01291.1 - 1.4e-40 138.5 27.7 1.7e-40 138.1 19.2 1.1 1 0 0 1 1 1 1 Snf7 YlqD PF11068.3 KOH01291.1 - 0.0033 17.4 16.9 0.0033 17.4 11.7 2.2 1 1 1 2 2 2 1 YlqD protein V_ATPase_I PF01496.14 KOH01291.1 - 0.01 13.7 8.1 0.012 13.4 5.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TrfA PF07042.6 KOH01291.1 - 0.044 12.5 1.5 0.068 11.9 1.0 1.3 1 0 0 1 1 1 0 TrfA protein Fmp27_SW PF10305.4 KOH01291.1 - 0.055 13.9 2.8 0.087 13.2 0.0 2.5 2 1 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Ribosomal_L29 PF00831.18 KOH01291.1 - 0.12 12.0 8.4 0.14 11.8 0.0 3.5 3 1 0 3 3 3 0 Ribosomal L29 protein COG2 PF06148.6 KOH01291.1 - 0.35 10.7 9.0 0.16 11.8 3.9 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1395 PF07160.7 KOH01291.1 - 0.66 9.4 14.4 1.1 8.6 9.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1395) Peptidase_S46 PF10459.4 KOH01291.1 - 0.79 8.0 12.8 0.96 7.7 8.9 1.1 1 0 0 1 1 1 0 Peptidase S46 Tropomyosin_1 PF12718.2 KOH01291.1 - 1.4 8.8 18.1 0.2 11.5 8.9 2.1 1 1 1 2 2 2 0 Tropomyosin like XhlA PF10779.4 KOH01291.1 - 1.7 8.6 24.9 0.24 11.3 1.4 4.1 2 1 3 5 5 5 0 Haemolysin XhlA BLOC1_2 PF10046.4 KOH01291.1 - 1.8 8.7 23.9 1.5 9.0 4.0 3.0 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Uds1 PF15456.1 KOH01291.1 - 1.8 8.5 11.9 3.6 7.5 8.2 1.7 1 1 0 1 1 1 0 Up-regulated During Septation Reo_sigmaC PF04582.7 KOH01291.1 - 2 7.5 11.7 0.97 8.5 6.1 1.7 1 1 1 2 2 2 0 Reovirus sigma C capsid protein FlaC_arch PF05377.6 KOH01291.1 - 2.5 8.0 9.9 4.7 7.1 0.3 3.5 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) Striatin PF08232.7 KOH01291.1 - 2.6 8.3 14.8 2 8.7 9.0 1.8 1 1 1 2 2 2 0 Striatin family Cep57_MT_bd PF06657.8 KOH01291.1 - 2.9 7.9 12.8 0.42 10.5 4.3 2.6 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF1664 PF07889.7 KOH01291.1 - 3.7 7.3 13.9 0.3 10.8 4.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Sec34 PF04136.10 KOH01291.1 - 4.5 6.9 15.8 4.2 7.0 5.8 2.2 1 1 1 2 2 2 0 Sec34-like family CALCOCO1 PF07888.6 KOH01291.1 - 4.7 5.3 18.8 5.8 5.0 13.0 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF3450 PF11932.3 KOH01291.1 - 6.1 6.0 27.4 0.41 9.8 9.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Ax_dynein_light PF10211.4 KOH01291.1 - 6.6 6.5 19.0 0.44 10.3 6.7 2.4 1 1 2 3 3 3 0 Axonemal dynein light chain DUF4200 PF13863.1 KOH01291.1 - 6.9 6.6 19.3 6.3 6.7 11.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF972 PF06156.8 KOH01291.1 - 8.6 6.7 20.1 1.2 9.5 6.6 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF972) DHBP_synthase PF00926.14 KOH01292.1 - 5.5e-78 260.6 0.0 6.1e-78 260.4 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase WD40 PF00400.27 KOH01293.1 - 3.5e-06 26.6 1.9 6.8e-05 22.5 0.3 3.2 3 0 0 3 3 3 1 WD domain, G-beta repeat Afaf PF15339.1 KOH01293.1 - 0.047 13.2 0.1 0.15 11.6 0.0 1.8 2 0 0 2 2 2 0 Acrosome formation-associated factor Sld5 PF05916.6 KOH01294.1 - 1.6e-13 50.9 0.4 3.4e-13 49.8 0.3 1.6 1 0 0 1 1 1 1 GINS complex protein NCKAP5 PF15246.1 KOH01294.1 - 0.11 11.8 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein Pkinase PF00069.20 KOH01295.1 - 2.5e-63 213.6 0.0 3.9e-63 213.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH01295.1 - 1.8e-31 109.1 0.0 2.7e-31 108.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH01295.1 - 1.6e-09 37.1 0.0 1.2e-07 31.0 0.0 2.8 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOH01295.1 - 0.0048 15.9 0.0 0.013 14.5 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOH01295.1 - 0.02 14.6 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family HlyIII PF03006.15 KOH01296.1 - 1.1e-54 185.1 25.3 1.4e-54 184.8 17.5 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF4231 PF14015.1 KOH01296.1 - 0.46 10.4 2.2 0.57 10.1 0.0 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF4231) Shisa PF13908.1 KOH01296.1 - 1.9 8.6 7.0 2.8 8.0 0.1 2.7 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator Vps39_2 PF10367.4 KOH01299.1 - 0.64 10.2 6.1 0.16 12.1 0.2 3.0 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 CPL PF08144.6 KOH01300.1 - 4.2e-20 72.0 0.2 1.2e-17 64.1 0.0 3.0 3 0 0 3 3 3 2 CPL (NUC119) domain PUF PF00806.14 KOH01300.1 - 1.6e-05 24.0 7.9 0.11 12.0 0.0 6.6 7 0 0 7 7 7 1 Pumilio-family RNA binding repeat Daxx PF03344.10 KOH01300.1 - 0.048 12.1 17.6 0.068 11.6 12.2 1.2 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 KOH01300.1 - 3.1 5.6 24.9 6.5 4.5 17.2 1.5 1 0 0 1 1 1 0 Nop14-like family Sugar_tr PF00083.19 KOH01301.1 - 4.2e-147 490.3 30.1 4.9e-147 490.1 20.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOH01301.1 - 4.7e-31 107.7 32.9 1.7e-30 105.9 19.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.8 KOH01301.1 - 0.00011 20.5 0.5 0.00011 20.5 0.3 2.0 2 0 0 2 2 2 1 Transmembrane secretion effector Lig_chan PF00060.21 KOH01301.1 - 5.5 6.6 13.2 2.1 8.0 0.1 3.9 3 2 0 3 3 3 0 Ligand-gated ion channel Sec20 PF03908.8 KOH01302.1 - 1.6e-33 114.2 0.7 3.9e-33 113.0 0.5 1.7 1 0 0 1 1 1 1 Sec20 LCD1 PF09798.4 KOH01303.1 - 1.9e-255 848.9 35.6 2.2e-255 848.7 24.7 1.0 1 0 0 1 1 1 1 DNA damage checkpoint protein Phage_lysis PF03245.8 KOH01303.1 - 0.012 15.5 3.0 0.028 14.4 2.1 1.6 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein DUF342 PF03961.8 KOH01303.1 - 5 5.4 13.7 0.21 9.9 5.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF342) FHA PF00498.21 KOH01305.1 - 2.6e-05 24.2 0.0 9.2e-05 22.4 0.0 2.0 1 0 0 1 1 1 1 FHA domain S-AdoMet_synt_C PF02773.11 KOH01306.1 - 9.8e-75 248.8 0.3 1.5e-74 248.2 0.2 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 KOH01306.1 - 1.3e-46 157.4 0.0 2.5e-46 156.4 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 KOH01306.1 - 1.2e-44 150.5 0.2 2.6e-44 149.5 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain PAP2 PF01569.16 KOH01307.1 - 8.4e-22 77.2 1.2 6.6e-21 74.3 1.0 2.0 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.1 KOH01307.1 - 1.6e-05 24.5 0.4 2.9e-05 23.6 0.3 1.5 1 0 0 1 1 1 1 PAP2 superfamily DUF1282 PF06930.7 KOH01307.1 - 0.0032 17.1 0.5 0.25 10.9 0.0 2.5 3 1 0 3 3 3 1 Protein of unknown function (DUF1282) PAP2_C PF14360.1 KOH01307.1 - 0.014 15.6 6.4 0.014 15.6 4.4 2.4 3 0 0 3 3 3 0 PAP2 superfamily C-terminal PSP1 PF04468.7 KOH01308.1 - 1.3e-37 127.6 0.1 2.9e-37 126.5 0.1 1.6 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Cu-oxidase_2 PF07731.9 KOH01309.1 - 1.5e-24 86.0 2.3 5.8e-23 80.9 1.2 2.9 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_3 PF07732.10 KOH01309.1 - 2.8e-19 68.9 8.3 8.9e-17 60.9 0.5 3.5 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.17 KOH01309.1 - 1e-17 64.5 3.1 2e-16 60.3 0.0 3.6 4 1 0 4 4 4 1 Multicopper oxidase Cupredoxin_1 PF13473.1 KOH01309.1 - 0.14 12.0 0.0 22 5.0 0.0 3.2 3 0 0 3 3 3 0 Cupredoxin-like domain Pkinase PF00069.20 KOH01310.1 - 2.5e-73 246.4 0.3 1.1e-72 244.3 0.0 2.3 2 1 1 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH01310.1 - 2.5e-34 118.5 0.0 1.9e-33 115.6 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH01310.1 - 6.4e-07 28.6 0.0 4.4e-06 25.8 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 KOH01310.1 - 0.18 11.5 0.0 0.36 10.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF106 PF01956.11 KOH01310.1 - 8.4 5.8 6.4 35 3.8 4.4 2.1 1 0 0 1 1 1 0 Integral membrane protein DUF106 AA_permease PF00324.16 KOH01311.1 - 3e-130 434.7 35.1 3.4e-130 434.5 24.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KOH01311.1 - 1.2e-31 109.7 33.3 1.4e-31 109.4 23.1 1.1 1 0 0 1 1 1 1 Amino acid permease Rad60-SLD PF11976.3 KOH01312.1 - 1.1e-20 73.0 0.6 2e-20 72.2 0.2 1.5 1 1 1 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 KOH01312.1 - 6.6e-13 47.8 0.1 8.6e-13 47.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family SRP9-21 PF05486.7 KOH01312.1 - 0.058 13.1 0.0 0.07 12.8 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) Complex1_LYR_1 PF13232.1 KOH01313.1 - 9.7e-09 35.3 0.0 1.8e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 KOH01313.1 - 2.7e-08 33.5 0.0 7e-08 32.1 0.0 1.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.1 KOH01313.1 - 8.1e-05 23.0 0.1 0.00011 22.6 0.1 1.3 1 0 0 1 1 1 1 Complex1_LYR-like DUF4028 PF13220.1 KOH01313.1 - 0.037 13.6 0.0 0.071 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4028) Fe_dep_repr_C PF02742.10 KOH01313.1 - 0.038 13.6 0.5 0.24 11.1 0.0 2.0 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain Pox_D2 PF04701.8 KOH01313.1 - 0.14 12.1 1.5 0.95 9.4 0.3 2.0 1 1 1 2 2 2 0 Pox virus D2 protein DUF3128 PF11326.3 KOH01314.1 - 1.1e-28 99.1 0.9 1.3e-28 98.9 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) CHCH PF06747.8 KOH01314.1 - 0.013 15.3 2.5 2.5 8.1 0.0 2.4 2 0 0 2 2 2 0 CHCH domain Glutaredoxin PF00462.19 KOH01315.1 - 1.3e-16 60.3 0.0 2.9e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.1 KOH01315.1 - 6.4e-05 22.6 0.2 0.0021 17.8 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin domain Thioredoxin_9 PF14595.1 KOH01315.1 - 0.012 15.2 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_4 PF13462.1 KOH01315.1 - 0.18 11.8 0.4 1.8 8.5 0.0 2.0 1 1 0 2 2 2 0 Thioredoxin La PF05383.12 KOH01317.1 - 1e-20 73.2 0.1 2.3e-20 72.1 0.0 1.7 1 0 0 1 1 1 1 La domain Hexokinase_2 PF03727.11 KOH01318.1 - 1.4e-84 283.1 0.0 1.9e-84 282.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KOH01318.1 - 5.1e-67 225.1 0.0 7.7e-67 224.6 0.0 1.3 1 0 0 1 1 1 1 Hexokinase GRASP55_65 PF04495.9 KOH01319.1 - 2.4e-36 124.7 0.0 6.8e-35 120.0 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain FKBP_C PF00254.23 KOH01320.1 - 3.5e-33 113.4 0.0 4.3e-33 113.2 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Recep_L_domain PF01030.19 KOH01321.1 - 1.1e-12 47.8 13.7 6.8e-06 26.0 0.1 4.1 1 1 2 3 3 3 3 Receptor L domain LRR_5 PF13306.1 KOH01321.1 - 0.042 13.5 8.3 0.66 9.6 0.1 3.0 1 1 0 2 2 2 0 Leucine rich repeats (6 copies) Pkinase PF00069.20 KOH01322.1 - 2.7e-64 216.8 0.0 4.8e-64 216.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH01322.1 - 7.9e-48 162.7 0.0 1.3e-47 162.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH01322.1 - 1.4e-07 30.7 0.0 5.3e-06 25.6 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOH01322.1 - 0.087 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ArfGap PF01412.13 KOH01323.1 - 1.4e-30 105.4 3.4 3.7e-30 104.1 2.3 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pmp3 PF01679.12 KOH01325.1 - 3.2e-21 74.7 6.2 3.7e-21 74.5 4.3 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator RPAP1_C PF08620.5 KOH01326.1 - 5.6e-32 109.4 0.1 1.2e-31 108.3 0.0 1.6 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.5 KOH01326.1 - 6.7e-16 57.6 3.9 6.7e-16 57.6 2.7 2.0 2 0 0 2 2 2 1 RPAP1-like, N-terminal MAS20 PF02064.10 KOH01326.1 - 3 7.7 6.0 8.6 6.2 1.8 2.4 2 0 0 2 2 2 0 MAS20 protein import receptor UCR_14kD PF02271.11 KOH01328.1 - 3.9e-44 148.7 0.1 4.5e-44 148.5 0.1 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit ATP_transf PF09830.4 KOH01329.1 - 4.1e-21 74.5 0.0 6.8e-21 73.8 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.18 KOH01329.1 - 0.00054 20.4 0.0 0.0013 19.2 0.0 1.6 1 0 0 1 1 1 1 HIT domain Fumble PF03630.9 KOH01330.1 - 1.5e-132 441.6 7.3 1.1e-129 432.1 3.2 2.0 1 1 1 2 2 2 2 Fumble DUF2082 PF09855.4 KOH01330.1 - 0.04 13.7 0.1 0.14 12.0 0.0 1.9 1 0 0 1 1 1 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) DUF1216 PF06746.6 KOH01331.1 - 0.075 12.8 4.6 7.9 6.2 0.3 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1216) Reo_sigmaC PF04582.7 KOH01331.1 - 0.11 11.7 0.4 0.19 10.8 0.3 1.5 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Pup PF05639.6 KOH01331.1 - 0.6 10.6 6.8 0.34 11.4 0.3 3.0 2 0 0 2 2 2 0 Pup-like protein Sec2p PF06428.6 KOH01331.1 - 2.7 7.8 12.2 0.077 12.8 0.8 2.9 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p Aminotran_3 PF00202.16 KOH01332.1 - 2.7e-94 315.7 0.0 3.3e-94 315.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Fungal_trans PF04082.13 KOH01333.1 - 1.5e-30 105.9 2.0 2.6e-30 105.1 1.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain PA14 PF07691.7 KOH01334.1 - 8.3e-29 100.1 0.0 1.6e-28 99.1 0.0 1.5 1 0 0 1 1 1 1 PA14 domain PA14_2 PF10528.4 KOH01334.1 - 4.6e-15 55.5 2.7 8.3e-15 54.7 0.3 2.7 2 0 0 2 2 2 1 GLEYA domain Flocculin PF00624.13 KOH01334.1 - 7e-06 25.7 25.2 7e-06 25.7 17.5 5.9 4 1 1 5 5 5 1 Flocculin repeat ELFV_dehydrog PF00208.16 KOH01335.1 - 1e-82 277.4 4.6 1.2e-82 277.1 3.2 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 KOH01335.1 - 4.8e-47 158.8 0.0 8.5e-47 158.0 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ADH_N PF08240.7 KOH01336.1 - 1.4e-35 121.2 0.7 2.4e-35 120.5 0.5 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOH01336.1 - 2.5e-23 82.0 0.0 3.7e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pyr_redox_3 PF13738.1 KOH01336.1 - 0.0058 16.7 0.0 0.0097 15.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N_2 PF13602.1 KOH01336.1 - 0.0065 17.3 0.0 0.012 16.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Prim_Zn_Ribbon PF08273.7 KOH01336.1 - 0.013 15.5 1.3 0.039 14.0 0.9 1.8 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase F420_oxidored PF03807.12 KOH01336.1 - 0.018 15.4 0.1 0.042 14.2 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 KOH01336.1 - 0.032 14.3 0.0 0.07 13.2 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 KOH01336.1 - 0.09 11.9 0.0 0.2 10.8 0.0 1.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.22 KOH01336.1 - 0.13 12.7 0.1 0.72 10.3 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ADH_N PF08240.7 KOH01337.1 - 2.5e-34 117.3 5.3 4.6e-34 116.4 3.6 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOH01337.1 - 5.8e-24 84.1 0.0 8.5e-24 83.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase F420_oxidored PF03807.12 KOH01337.1 - 0.11 12.9 0.1 27 5.2 0.0 2.4 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Alb1 PF09135.6 KOH01338.1 - 2.6e-25 89.1 12.7 2.6e-25 89.1 8.8 2.0 2 0 0 2 2 2 1 Alb1 CTV_P33 PF07184.6 KOH01338.1 - 0.13 11.0 0.7 0.36 9.6 0.1 1.8 2 0 0 2 2 2 0 Citrus tristeza virus P33 protein NCKAP5 PF15246.1 KOH01338.1 - 0.14 11.4 8.6 0.23 10.8 6.0 1.3 1 1 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein Calreticulin PF00262.13 KOH01339.1 - 2.7e-119 398.1 5.9 3.1e-119 397.9 4.1 1.0 1 0 0 1 1 1 1 Calreticulin family Kelch_4 PF13418.1 KOH01340.1 - 7.4e-14 51.2 0.3 3.6e-05 23.4 0.0 5.2 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_3 PF13415.1 KOH01340.1 - 1.4e-08 34.6 0.3 0.017 15.2 0.0 5.7 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.1 KOH01340.1 - 8.3e-08 32.0 5.1 0.013 15.4 0.0 5.6 6 1 0 6 6 6 2 Kelch motif Kelch_1 PF01344.20 KOH01340.1 - 2e-06 27.2 3.7 0.089 12.3 0.0 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.1 KOH01340.1 - 8.5e-05 22.5 0.7 17 5.7 0.0 4.9 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.10 KOH01340.1 - 0.00017 21.1 3.9 0.66 9.8 0.0 5.2 6 0 0 6 6 6 1 Kelch motif Peroxin-22 PF12827.2 KOH01341.1 - 1.5e-28 98.8 0.0 2e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 Peroxisomal biogenesis protein family FPN1 PF06963.7 KOH01341.1 - 0.05 11.9 0.0 0.063 11.6 0.0 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) CRAL_TRIO_2 PF13716.1 KOH01341.1 - 0.056 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain AMP-binding PF00501.23 KOH01342.1 - 2.6e-91 306.1 0.0 3.2e-91 305.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 KOH01342.1 - 3.5e-20 72.7 0.0 8.8e-19 68.2 0.0 2.7 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain GNAT_acetyltran PF12746.2 KOH01342.1 - 0.019 13.8 0.0 0.035 12.9 0.0 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase TRP PF06011.7 KOH01343.1 - 2.8e-157 523.7 36.2 4e-157 523.2 25.1 1.2 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 KOH01343.1 - 5.3e-45 152.9 0.9 9.4e-45 152.1 0.7 1.4 1 0 0 1 1 1 1 ML-like domain Neur_chan_memb PF02932.11 KOH01343.1 - 0.00071 19.5 1.8 0.0016 18.4 0.0 2.3 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region DUF4154 PF13689.1 KOH01343.1 - 0.022 14.3 0.0 0.054 13.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4154) Zn_clus PF00172.13 KOH01344.1 - 7.2e-12 45.0 10.5 1.3e-11 44.2 7.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DLH PF01738.13 KOH01345.1 - 2.5e-41 141.3 0.0 2.9e-41 141.1 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 KOH01345.1 - 1.8e-07 31.0 0.0 2.2e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Miro PF08477.8 KOH01346.1 - 1.4e-50 170.7 0.0 2.4e-25 89.3 0.0 2.4 2 0 0 2 2 2 2 Miro-like protein EF_assoc_2 PF08356.7 KOH01346.1 - 2.9e-29 100.6 0.1 1.1e-28 98.7 0.0 2.1 2 0 0 2 2 2 1 EF hand associated EF_assoc_1 PF08355.7 KOH01346.1 - 8.4e-27 92.2 1.9 1.5e-26 91.4 1.3 1.4 1 0 0 1 1 1 1 EF hand associated Ras PF00071.17 KOH01346.1 - 7.9e-26 90.3 0.0 3.7e-14 52.4 0.0 2.7 2 1 0 2 2 2 2 Ras family MMR_HSR1 PF01926.18 KOH01346.1 - 1.6e-07 31.2 0.0 0.012 15.6 0.0 2.9 2 1 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_1 PF00036.27 KOH01346.1 - 3.9e-06 25.7 1.1 0.0032 16.6 0.2 3.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOH01346.1 - 1e-05 25.5 3.5 0.037 14.1 0.0 3.1 3 0 0 3 3 2 2 EF-hand domain pair Dynamin_N PF00350.18 KOH01346.1 - 3.1e-05 23.8 0.0 0.1 12.3 0.0 2.5 2 0 0 2 2 2 2 Dynamin family Arf PF00025.16 KOH01346.1 - 0.00012 21.3 0.0 0.0022 17.2 0.0 2.5 3 0 0 3 3 3 1 ADP-ribosylation factor family EF-hand_6 PF13405.1 KOH01346.1 - 0.0011 18.7 1.8 0.056 13.3 0.1 3.2 2 0 0 2 2 2 1 EF-hand domain AAA_24 PF13479.1 KOH01346.1 - 0.002 17.7 0.0 0.03 13.8 0.0 2.7 3 0 0 3 3 2 1 AAA domain ABC_tran PF00005.22 KOH01346.1 - 0.002 18.3 0.0 1.6 8.9 0.0 2.4 2 0 0 2 2 2 1 ABC transporter DUF258 PF03193.11 KOH01346.1 - 0.0021 17.2 0.1 0.057 12.6 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 KOH01346.1 - 0.0023 17.9 0.1 1.3 8.9 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.1 KOH01346.1 - 0.0037 17.2 0.0 2.9 7.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 KOH01346.1 - 0.0049 16.3 0.0 2.3 7.8 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain EF-hand_5 PF13202.1 KOH01346.1 - 0.0055 15.9 0.4 0.032 13.5 0.3 2.5 1 0 0 1 1 1 1 EF hand AAA_33 PF13671.1 KOH01346.1 - 0.025 14.4 0.0 10 5.9 0.0 3.2 3 0 0 3 3 3 0 AAA domain FeoB_N PF02421.13 KOH01346.1 - 0.026 13.8 0.1 6 6.1 0.0 2.9 3 0 0 3 3 3 0 Ferrous iron transport protein B Arch_ATPase PF01637.13 KOH01346.1 - 0.03 14.0 0.3 5.6 6.5 0.0 2.8 2 1 0 2 2 2 0 Archaeal ATPase AAA_18 PF13238.1 KOH01346.1 - 0.039 14.2 0.0 11 6.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 KOH01346.1 - 0.049 13.7 0.0 2.2 8.4 0.0 2.8 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.8 KOH01346.1 - 0.063 12.2 0.0 4 6.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MobB PF03205.9 KOH01346.1 - 0.071 12.8 0.1 1 9.0 0.1 2.6 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B Septin PF00735.13 KOH01346.1 - 0.076 12.0 0.0 1.2 8.0 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_17 PF13207.1 KOH01346.1 - 0.11 13.3 0.0 16 6.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain MCM PF00493.18 KOH01346.1 - 0.13 11.0 0.0 4.4 5.9 0.0 2.3 2 0 0 2 2 2 0 MCM2/3/5 family Mto2_bdg PF12808.2 KOH01347.1 - 2.9e-05 24.0 8.5 2.9e-05 24.0 5.9 3.6 3 0 0 3 3 3 2 Micro-tubular organiser Mto1 C-term Mto2-binding region HALZ PF02183.13 KOH01347.1 - 0.19 11.4 14.3 3 7.6 0.3 4.9 4 0 0 4 4 4 0 Homeobox associated leucine zipper BolA PF01722.13 KOH01348.1 - 5.5e-17 61.4 0.0 9.3e-17 60.7 0.0 1.3 1 0 0 1 1 1 1 BolA-like protein PHY PF00360.15 KOH01348.1 - 0.04 13.0 0.0 0.054 12.6 0.0 1.2 1 0 0 1 1 1 0 Phytochrome region BolA PF01722.13 KOH01349.1 - 1.2e-23 82.7 0.0 1.9e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 BolA-like protein RPA_C PF08784.6 KOH01349.1 - 0.093 13.1 0.4 2.1 8.8 0.0 2.1 2 0 0 2 2 2 0 Replication protein A C terminal GCV_H PF01597.14 KOH01350.1 - 7.2e-47 158.0 0.8 8.8e-47 157.7 0.6 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.17 KOH01350.1 - 0.00085 18.9 0.2 0.0023 17.5 0.1 1.8 1 1 0 1 1 1 1 Biotin-requiring enzyme DUF3453 PF11935.3 KOH01351.1 - 8e-67 225.1 0.9 2.5e-66 223.5 0.0 2.3 2 1 1 3 3 3 1 Domain of unknown function (DUF3453) COPIIcoated_ERV PF07970.7 KOH01352.1 - 1.7e-71 240.3 0.4 2.1e-71 240.0 0.3 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 KOH01352.1 - 2e-32 110.9 0.1 4.1e-32 110.0 0.1 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) RhoGEF PF00621.15 KOH01353.1 - 4.2e-36 124.5 5.0 4.2e-36 124.5 3.5 2.3 2 1 0 2 2 2 1 RhoGEF domain CDC24 PF06395.6 KOH01353.1 - 5.2e-36 122.5 1.3 6.2e-35 119.1 0.6 2.7 2 0 0 2 2 2 1 CDC24 Calponin PH_10 PF15411.1 KOH01353.1 - 7.3e-19 68.0 9.6 4.5e-09 36.5 0.2 3.4 2 1 0 3 3 3 2 Pleckstrin homology domain PB1 PF00564.19 KOH01353.1 - 0.00064 19.3 0.0 0.0025 17.4 0.0 2.1 1 1 0 1 1 1 1 PB1 domain Cyclin_N PF00134.18 KOH01354.1 - 5.4e-24 84.1 2.9 9.6e-24 83.3 2.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyto_heme_lyase PF01265.12 KOH01355.1 - 2.2e-72 243.7 0.1 2.8e-72 243.4 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase PK PF00224.16 KOH01356.1 - 1.1e-166 553.7 1.5 1.3e-166 553.4 1.1 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 KOH01356.1 - 2.1e-28 98.2 0.1 5.9e-28 96.7 0.0 1.8 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 KOH01356.1 - 1e-05 24.5 0.4 2.4e-05 23.3 0.1 1.7 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family TGS PF02824.16 KOH01358.1 - 3.3e-22 78.0 0.1 5.9e-22 77.2 0.1 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 KOH01358.1 - 8e-17 61.2 0.0 1.6e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOH01358.1 - 3.7e-10 39.3 0.1 1.1e-09 37.7 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 KOH01358.1 - 0.0056 16.5 0.5 3.6 7.3 0.2 2.3 1 1 1 2 2 2 2 Dynamin family ArgK PF03308.11 KOH01358.1 - 0.0088 14.8 0.2 0.015 14.0 0.1 1.3 1 0 0 1 1 1 1 ArgK protein GTP_EFTU PF00009.22 KOH01358.1 - 0.0097 15.3 0.0 11 5.3 0.0 3.5 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain Miro PF08477.8 KOH01358.1 - 0.023 15.1 0.0 0.047 14.1 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein AAA_28 PF13521.1 KOH01358.1 - 0.16 11.9 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 KOH01359.1 - 7.8e-31 106.9 0.0 7.8e-31 106.9 0.0 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 KOH01359.1 - 1.1e-21 76.6 0.0 3.8e-21 75.0 0.0 2.0 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 KOH01359.1 - 1.1e-14 54.2 1.1 1.2e-09 38.1 0.0 3.1 2 0 0 2 2 2 2 Elongation factor Tu domain 2 AAA_22 PF13401.1 KOH01359.1 - 0.024 14.7 0.1 0.17 12.0 0.1 2.5 1 1 0 1 1 1 0 AAA domain Mis12 PF05859.7 KOH01360.1 - 4.1e-48 162.8 3.6 4.1e-48 162.8 2.5 2.0 2 1 0 2 2 2 1 Mis12 protein TetR_C_4 PF08359.6 KOH01360.1 - 0.024 14.5 0.7 0.058 13.3 0.3 1.9 1 1 0 1 1 1 0 YsiA-like protein, C-terminal region Phasin PF05597.6 KOH01360.1 - 0.086 12.6 4.7 5.5 6.7 0.0 3.0 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) BLOC1_2 PF10046.4 KOH01360.1 - 0.43 10.7 9.3 0.11 12.5 1.2 3.1 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2203 PF09969.4 KOH01360.1 - 2.6 8.2 5.0 23 5.2 2.0 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) SWIRM PF04433.12 KOH01361.1 - 5.6e-14 52.0 0.0 1.1e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 SWIRM domain IL3 PF02059.10 KOH01361.1 - 0.21 11.5 2.0 2.5 8.1 0.0 2.4 2 0 0 2 2 2 0 Interleukin-3 RNase_P_Rpp14 PF01900.14 KOH01362.1 - 7.5e-32 109.4 0.1 9.6e-32 109.0 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family SKIP_SNW PF02731.10 KOH01363.1 - 1.9e-44 150.8 1.3 3.2e-44 150.1 0.9 1.3 1 0 0 1 1 1 1 SKIP/SNW domain Myosin_head PF00063.16 KOH01365.1 - 1.3e-257 856.4 12.9 2.3e-257 855.5 8.9 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.14 KOH01365.1 - 7.5e-24 83.6 1.1 1.9e-23 82.3 0.8 1.8 1 0 0 1 1 1 1 DIL domain IQ PF00612.22 KOH01365.1 - 1.4e-05 24.2 28.0 0.011 15.3 0.3 6.6 6 0 0 6 6 6 3 IQ calmodulin-binding motif AAA_22 PF13401.1 KOH01365.1 - 0.0018 18.4 0.1 0.011 15.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain Myosin_N PF02736.14 KOH01365.1 - 0.01 15.4 0.0 0.033 13.8 0.0 1.9 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain ABC_tran PF00005.22 KOH01365.1 - 0.07 13.4 1.4 0.21 11.8 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_19 PF13245.1 KOH01365.1 - 0.18 11.5 0.0 0.39 10.4 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain Hph PF13694.1 KOH01366.1 - 2.6e-43 148.2 9.2 2.6e-43 148.2 6.4 2.5 1 1 1 2 2 2 1 Sec63/Sec62 complex-interacting family Sec8_exocyst PF04048.9 KOH01366.1 - 0.001 18.6 3.3 0.026 14.1 0.1 2.5 1 1 1 2 2 2 2 Sec8 exocyst complex component specific domain Saw1 PF11561.3 KOH01367.1 - 1e-65 221.2 5.2 1.2e-65 221.0 3.6 1.0 1 0 0 1 1 1 1 Single strand annealing-weakened 1 E1-E2_ATPase PF00122.15 KOH01368.1 - 2.2e-19 69.4 0.5 4e-19 68.5 0.3 1.4 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 KOH01368.1 - 8.1e-19 68.5 0.3 2.5e-18 66.9 0.2 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOH01368.1 - 4.1e-13 50.2 0.8 2.7e-10 41.0 0.4 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOH01368.1 - 4.7e-10 39.2 0.0 1.3e-09 37.8 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 KOH01368.1 - 0.00063 19.3 0.4 0.0053 16.3 0.3 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Mak16 PF04874.9 KOH01369.1 - 5.3e-37 125.9 16.6 5.3e-37 125.9 11.5 2.7 2 1 0 2 2 2 1 Mak16 protein C-terminal region Ribosomal_L28e PF01778.12 KOH01369.1 - 5.8e-33 113.7 1.7 5.8e-33 113.7 1.2 1.8 2 0 0 2 2 2 1 Ribosomal L28e protein family TFIIF_alpha PF05793.7 KOH01369.1 - 1.4 7.2 33.2 1.8 6.8 23.0 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BUD22 PF09073.5 KOH01369.1 - 4.6 6.1 38.6 8.3 5.3 26.7 1.6 1 1 0 1 1 1 0 BUD22 Nop14 PF04147.7 KOH01369.1 - 5.9 4.6 30.7 8 4.2 21.3 1.3 1 0 0 1 1 1 0 Nop14-like family RasGEF PF00617.14 KOH01370.1 - 1e-43 149.2 1.0 1e-43 149.2 0.7 2.2 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 KOH01370.1 - 2.3e-14 53.3 11.1 2e-13 50.3 0.1 4.1 4 0 0 4 4 4 2 RasGEF N-terminal motif PMT PF02366.13 KOH01371.1 - 2.1e-92 308.9 22.0 2.1e-92 308.9 15.2 2.3 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 KOH01371.1 - 1.2e-26 93.4 1.4 2.5e-26 92.3 0.1 2.0 2 0 0 2 2 2 1 MIR domain Nucleoside_tran PF01733.13 KOH01372.1 - 5.3e-98 327.9 3.8 5.3e-98 327.9 2.7 1.6 2 0 0 2 2 2 1 Nucleoside transporter Sigma70_ner PF04546.8 KOH01372.1 - 0.042 13.4 0.4 0.042 13.4 0.3 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region DUF2796 PF10986.3 KOH01372.1 - 0.059 13.3 0.1 0.059 13.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) PBP1_TM PF14812.1 KOH01372.1 - 0.29 11.4 5.5 2.2 8.6 0.4 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ATP-synt_8 PF00895.15 KOH01372.1 - 0.47 10.6 0.1 0.47 10.6 0.1 4.5 4 1 0 4 4 4 0 ATP synthase protein 8 Exo_endo_phos PF03372.18 KOH01373.1 - 4.2e-24 85.8 0.6 6.4e-24 85.2 0.4 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.2 KOH01373.1 - 3.2e-15 55.3 4.0 5.9e-11 41.7 0.8 3.8 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOH01373.1 - 3.5e-13 49.0 4.9 3e-09 36.5 0.3 3.3 1 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 KOH01373.1 - 6.5e-11 40.6 11.2 0.0022 17.7 0.1 6.5 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_7 PF13504.1 KOH01373.1 - 2.5e-07 29.7 11.2 0.01 15.8 0.2 5.9 5 0 0 5 5 5 2 Leucine rich repeat RCC1 PF00415.13 KOH01374.1 - 4.3e-24 84.4 18.4 1.3e-12 47.7 0.1 5.9 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOH01374.1 - 5.8e-15 54.4 29.5 7.9e-08 31.7 0.8 6.6 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat SNF2_N PF00176.18 KOH01375.1 - 5.7e-73 245.3 0.4 5.7e-73 245.3 0.3 2.3 3 0 0 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOH01375.1 - 1.5e-16 60.0 0.0 1.4e-13 50.4 0.0 2.9 2 0 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.1 KOH01375.1 - 0.023 14.8 0.0 0.17 12.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain Ras_bdg_2 PF14847.1 KOH01375.1 - 0.32 10.9 4.3 3.7 7.5 0.4 3.9 4 0 0 4 4 4 0 Ras-binding domain of Byr2 Sec62 PF03839.11 KOH01376.1 - 0.0084 15.5 0.6 0.0084 15.5 0.4 2.0 2 0 0 2 2 2 1 Translocation protein Sec62 Pkinase PF00069.20 KOH01377.1 - 8.8e-65 218.4 0.5 4.3e-63 212.8 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH01377.1 - 7.7e-23 80.8 0.0 1.3e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH01377.1 - 5.5e-09 35.4 0.0 9.5e-09 34.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOH01377.1 - 0.0015 18.3 0.0 0.0035 17.1 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 KOH01377.1 - 0.0032 16.5 0.0 0.008 15.2 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_9 PF13426.1 KOH01377.1 - 0.027 14.8 0.0 0.76 10.1 0.0 2.6 2 0 0 2 2 2 0 PAS domain RIO1 PF01163.17 KOH01377.1 - 0.046 13.0 0.1 0.11 11.7 0.1 1.6 1 0 0 1 1 1 0 RIO1 family PAS PF00989.19 KOH01377.1 - 0.09 12.5 0.0 2.3 8.0 0.0 2.6 2 0 0 2 2 2 0 PAS fold HEAT PF02985.17 KOH01378.1 - 1.6e-43 142.8 25.9 0.0025 17.7 0.0 13.3 13 1 1 14 14 14 12 HEAT repeat HEAT_2 PF13646.1 KOH01378.1 - 7.9e-31 106.2 2.4 5.3e-08 33.0 0.0 7.5 3 2 5 8 8 8 7 HEAT repeats Vac14_Fab1_bd PF12755.2 KOH01378.1 - 7.1e-13 48.7 5.9 0.059 13.7 0.0 7.6 3 3 5 8 8 8 4 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 KOH01378.1 - 1.2e-07 32.0 14.0 1.2 9.7 0.0 9.2 10 2 1 11 11 11 2 HEAT-like repeat Ecm29 PF13001.2 KOH01378.1 - 0.0023 16.4 3.4 1.4 7.3 0.0 3.3 3 0 0 3 3 3 2 Proteasome stabiliser Arm PF00514.18 KOH01378.1 - 0.0087 15.8 2.7 2.2 8.2 0.0 5.3 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat HhH-GPD PF00730.20 KOH01379.1 - 2.1e-21 76.2 0.0 3.7e-21 75.4 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 KOH01379.1 - 2.6e-09 36.2 0.0 7.6e-09 34.7 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.1 KOH01379.1 - 0.021 14.9 0.0 0.054 13.6 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain SNARE PF05739.14 KOH01380.1 - 1.3e-08 34.3 1.6 1.3e-08 34.3 1.1 2.3 3 0 0 3 3 3 1 SNARE domain DUF4175 PF13779.1 KOH01380.1 - 0.041 11.5 1.5 0.056 11.1 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Cys_Met_Meta_PP PF01053.15 KOH01381.1 - 1.3e-143 477.9 0.1 1.5e-143 477.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 KOH01381.1 - 0.00085 18.3 0.1 0.0018 17.3 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.14 KOH01381.1 - 0.0085 14.8 0.5 0.024 13.3 0.2 1.9 2 1 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 KOH01381.1 - 0.037 13.1 0.0 0.1 11.7 0.0 1.8 1 1 0 1 1 1 0 Beta-eliminating lyase GDC-P PF02347.11 KOH01381.1 - 0.064 11.9 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 Glycine cleavage system P-protein DegT_DnrJ_EryC1 PF01041.12 KOH01381.1 - 0.1 11.6 0.1 0.34 9.8 0.0 1.8 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family DUF3722 PF12519.3 KOH01383.1 - 6.5e-84 281.2 9.6 9.8e-84 280.6 6.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3722) CK2S PF15011.1 KOH01383.1 - 0.045 13.5 0.0 0.099 12.4 0.0 1.5 1 0 0 1 1 1 0 Casein Kinase 2 substrate Spo7 PF03907.8 KOH01384.1 - 1.3e-93 312.3 5.8 1.5e-93 312.1 4.0 1.0 1 0 0 1 1 1 1 Spo7-like protein FUN14 PF04930.10 KOH01385.1 - 1.1e-12 48.0 1.8 1.9e-12 47.3 1.3 1.4 1 0 0 1 1 1 1 FUN14 family Rab5ip PF07019.7 KOH01385.1 - 0.21 11.7 3.7 8.1 6.6 0.1 2.4 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) EMP24_GP25L PF01105.19 KOH01386.1 - 9.6e-35 119.9 0.1 1.1e-34 119.7 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2167 PF09935.4 KOH01386.1 - 0.084 11.6 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) HSP70 PF00012.15 KOH01387.1 - 5.5e-274 909.6 8.5 6.2e-274 909.5 5.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOH01387.1 - 5.7e-18 64.5 0.0 1e-16 60.4 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 KOH01387.1 - 0.0017 18.0 0.0 0.0046 16.5 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.5 KOH01387.1 - 0.002 17.0 0.5 0.043 12.6 0.1 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.13 KOH01387.1 - 0.083 11.9 1.1 0.37 9.8 0.0 2.4 2 1 1 3 3 3 0 Hydantoinase/oxoprolinase EF1_GNE PF00736.14 KOH01388.1 - 5.4e-33 112.5 2.2 1e-32 111.6 1.5 1.5 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.4 KOH01388.1 - 1.3e-12 47.6 5.9 1.3e-12 47.6 4.1 3.0 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region GST_C PF00043.20 KOH01388.1 - 0.003 17.5 0.2 0.065 13.2 0.1 2.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 KOH01388.1 - 0.022 14.6 0.1 0.12 12.2 0.0 2.1 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain DNA_pol3_a_NII PF11490.3 KOH01388.1 - 0.12 12.0 2.9 0.14 11.7 0.0 2.1 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Vps8 PF12816.2 KOH01389.1 - 1.9e-62 210.0 2.5 5.5e-62 208.5 1.8 1.9 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 zf-RING_2 PF13639.1 KOH01389.1 - 0.00077 19.2 1.2 0.003 17.3 0.8 2.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOH01389.1 - 0.00097 19.1 1.3 0.0039 17.1 0.9 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOH01389.1 - 0.0022 17.6 2.0 0.0087 15.6 1.4 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOH01389.1 - 0.0033 17.4 5.1 0.043 13.9 3.8 2.7 2 1 0 2 2 2 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 KOH01389.1 - 0.013 15.1 0.5 0.043 13.5 0.4 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.1 KOH01389.1 - 0.024 14.3 5.2 0.079 12.7 3.6 2.0 1 1 0 1 1 1 0 zinc-RING finger domain zf-Apc11 PF12861.2 KOH01389.1 - 0.089 12.6 2.0 0.097 12.5 0.3 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.24 KOH01389.1 - 0.094 12.4 2.1 0.3 10.8 1.4 1.9 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.1 KOH01389.1 - 0.14 12.0 1.7 0.41 10.5 1.2 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING B-block_TFIIIC PF04182.7 KOH01390.1 - 1.9e-15 56.4 0.0 6.3e-15 54.7 0.0 2.0 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC EMP24_GP25L PF01105.19 KOH01392.1 - 1.5e-47 161.7 0.1 1.8e-47 161.4 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD WD40 PF00400.27 KOH01393.1 - 2.5e-16 58.8 12.2 1.6e-10 40.4 0.2 5.5 7 0 0 7 7 7 3 WD domain, G-beta repeat eIF2A PF08662.6 KOH01393.1 - 7.8e-05 22.4 0.4 0.02 14.6 0.0 3.1 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A DUF3312 PF11768.3 KOH01393.1 - 0.029 12.6 0.0 0.052 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3312) PD40 PF07676.7 KOH01393.1 - 0.079 12.6 0.0 0.87 9.3 0.0 2.3 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat PTS_2-RNA PF01885.11 KOH01393.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family Rav1p_C PF12234.3 KOH01393.1 - 0.16 10.1 3.9 0.16 10.0 0.6 2.2 1 1 2 3 3 3 0 RAVE protein 1 C terminal Rep_fac-A_C PF08646.5 KOH01394.1 - 6.7e-59 197.7 1.2 5.6e-56 188.3 0.3 2.4 2 0 0 2 2 2 2 Replication factor-A C terminal domain tRNA_anti-codon PF01336.20 KOH01394.1 - 5.3e-14 51.8 0.9 6.1e-09 35.6 0.0 4.2 4 0 0 4 4 4 2 OB-fold nucleic acid binding domain Rep-A_N PF04057.7 KOH01394.1 - 4.8e-05 23.0 0.1 0.00012 21.8 0.0 1.7 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain DUF223 PF02721.9 KOH01394.1 - 0.00052 20.0 1.0 0.002 18.1 0.2 2.3 2 0 0 2 2 2 1 Domain of unknown function DUF223 BRCA-2_OB1 PF09103.5 KOH01394.1 - 0.0077 15.9 0.0 0.02 14.5 0.0 1.7 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 tRNA_int_endo PF01974.12 KOH01395.1 - 7.9e-14 51.2 0.0 1.3e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain DUP PF00674.13 KOH01397.1 - 5.7e-34 116.3 4.5 7.9e-34 115.8 2.6 1.7 2 0 0 2 2 2 1 DUP family Phospholamban PF04272.9 KOH01398.1 - 8.5 5.9 7.6 1.6 8.2 1.2 2.5 1 1 1 2 2 2 0 Phospholamban SH3_1 PF00018.23 KOH01399.1 - 1.2e-10 40.6 0.0 3.3e-10 39.1 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KOH01399.1 - 0.0011 18.4 0.0 0.0022 17.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAICAR_synt PF01259.13 KOH01400.1 - 4e-102 340.5 0.0 4.7e-102 340.3 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase Pkinase PF00069.20 KOH01401.1 - 2.1e-57 194.2 0.2 3.5e-57 193.5 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH01401.1 - 1.6e-31 109.3 0.1 3.3e-30 105.0 0.0 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Phage_GPO PF05929.6 KOH01401.1 - 0.0077 15.5 0.1 0.021 14.1 0.0 1.6 2 0 0 2 2 2 1 Phage capsid scaffolding protein (GPO) serine peptidase AAA_23 PF13476.1 KOH01401.1 - 0.0082 16.4 0.3 0.0082 16.4 0.2 1.7 2 0 0 2 2 2 1 AAA domain Kinase-like PF14531.1 KOH01401.1 - 0.032 13.1 0.0 0.058 12.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like ACCA PF03255.9 KOH01401.1 - 0.067 12.7 1.9 0.14 11.6 1.3 1.5 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Ldh_1_C PF02866.13 KOH01401.1 - 0.18 11.5 0.6 0.89 9.2 0.1 2.2 2 0 0 2 2 2 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain Pkinase PF00069.20 KOH01402.1 - 2.4e-67 226.8 0.0 3.9e-67 226.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOH01402.1 - 4.2e-51 173.5 0.0 6.5e-51 172.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOH01402.1 - 0.00056 18.9 0.1 0.011 14.7 0.0 2.2 2 0 0 2 2 2 1 Kinase-like DUP PF00674.13 KOH01404.1 - 3.5e-11 43.0 2.8 4.4e-11 42.6 2.0 1.1 1 0 0 1 1 1 1 DUP family DUP PF00674.13 KOH01405.1 - 4.6e-33 113.4 0.6 8.8e-33 112.4 0.4 1.4 1 0 0 1 1 1 1 DUP family Oxysterol_BP PF01237.13 KOH01406.1 - 4.7e-131 436.4 0.2 4.7e-131 436.4 0.1 1.9 2 0 0 2 2 2 1 Oxysterol-binding protein Ank_2 PF12796.2 KOH01406.1 - 1.2e-12 47.9 0.0 6.5e-06 26.4 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOH01406.1 - 2.4e-11 43.4 1.6 0.00012 22.2 0.0 3.6 4 0 0 4 4 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOH01406.1 - 3.5e-11 43.3 0.0 0.00012 22.5 0.0 3.2 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOH01406.1 - 5.2e-11 41.7 0.0 0.00098 18.8 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 KOH01406.1 - 9.7e-09 34.6 0.0 0.015 15.5 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat PH PF00169.24 KOH01406.1 - 8.9e-08 32.2 0.1 3.5e-07 30.3 0.1 2.1 1 0 0 1 1 1 1 PH domain PH_8 PF15409.1 KOH01406.1 - 2.1e-07 30.8 1.6 2.9e-07 30.4 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.1 KOH01406.1 - 9.7e-06 25.8 0.4 9.7e-06 25.8 0.3 3.0 3 0 0 3 3 3 1 Pleckstrin homology domain ALMT PF11744.3 KOH01406.1 - 0.64 8.6 3.1 1.3 7.5 2.2 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter LMBR1 PF04791.11 KOH01406.1 - 2.4 6.6 4.4 3.6 6.0 3.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein PA14 PF07691.7 KOH01407.1 - 5.9e-29 100.5 0.0 8.1e-29 100.1 0.0 1.2 1 0 0 1 1 1 1 PA14 domain PA14_2 PF10528.4 KOH01407.1 - 1.9e-15 56.8 0.5 4.4e-15 55.6 0.3 1.6 1 0 0 1 1 1 1 GLEYA domain